S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation 104923 70266 67870 67873 56369 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III 52637 246221 14718 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) 14417 14415 14645 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II 13075 13087 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 56473 54326 68801 74147 56348 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI 52815 GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation 110446 110460 93747 270076 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis 27053 PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation 111175 11671 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II 71707 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism 114663 228550 55980 320404 69718 19062 212111 320634 104015 16330 16331 16329 16332 233011 20975 17330 242291 101490 19211 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) 107869 12411 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 22247 69719 75533 56749 51797 110074 21915 55936 382985 18102 18103 79059 56520 54369 22169 66566 20135 66588 20133 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis 268566 SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis 216343 13195 21990 11298 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis 18194 15490 73166 98386 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis 56473 20216 233801 26458 272428 94180 328845 14081 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II 74157 234728 24018 67897 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis 23887 11687 17001 11684 14865 11689 625249 13479 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 68603 14593 110196 110446 319554 110460 15360 192156 100040592 17855 15357 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation 216456 14660 L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation 15233 234724 15445 14085 14874 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation 18948 12846 791260 26876 11669 17161 109731 11671 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II 245847 67980 26384 56174 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation 71761 108156 15109 243537 14317 NADH REPAIR%BIOCYC%PWY-6938 NADH repair 100043349 246703 URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) 64705 99586 103149 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds 18796 107650 18797 18798 103199 18799 72469 18795 18706 74769 18707 18711 18802 217837 74055 219024 114875 18717 27399 74302 84095 269437 104709 18803 228550 83493 234779 320404 76500 69718 72519 19062 75669 212111 327655 320634 75678 104015 320207 16330 18718 16331 52858 108083 16332 18704 233011 240752 20975 18705 17330 225326 18720 18719 19211 97287 67073 227399 18710 117150 271424 30955 18708 18709 224020 227733 269615 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation 212647 19125 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I 14651 109801 L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation 76282 108682 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA 68738 60525 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I 212503 228608 20229 69215 11754 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis 18478 ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing 11686 26569 320997 23801 545975 21816 433091 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis 107239 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis 22247 69719 56749 GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation 76952 22436 18950 14544 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation 20656 667310 12359 20657 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis 71780 114663 55980 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) 78330 68202 17716 17717 407790 17718 17719 17720 67003 22273 66694 100042918 67530 67273 70316 68198 66495 67130 75406 66416 68375 66108 104130 12858 66945 68342 12857 66377 17711 68197 227197 67184 100042503 17708 66046 17709 230075 17710 66916 67264 66218 54405 17991 66091 110323 66052 67680 66925 225887 100040287 12861 72900 239760 22272 66414 226646 624814 17995 17993 595136 623286 66445 17721 17722 12868 66142 12866 100041785 66152 17992 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis 227697 236082 57357 67422 52014 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 14450 68870 56248 108147 11565 100042069 23917 14923 11564 11566 231327 18103 237823 79059 78801 56520 67054 54369 11636 11637 229949 20135 635960 229363 20133 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) 69564 74080 226518 66454 225994 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt 14417 14415 14661 268860 214579 14645 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 66171 110208 14381 UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) 71365 71707 12850 56075 71883 217707 227683 52064 230027 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 100042069 23917 14923 18103 79059 56520 54369 20135 229363 20133 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis 108037 236539 100678 56433 20425 107272 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage 171567 14923 75533 18103 79059 13178 56520 27369 54369 18102 229949 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) 394434 13371 20887 13370 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation 216456 14660 27053 VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle 27973 69568 56316 18104 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I 107141 81906 13087 13078 13077 71519 74134 18984 20887 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation 11486 18950 GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I 23887 14862 14866 68312 76263 68396 16790 100042314 14863 14872 14871 14859 68214 56615 14874 211666 66447 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 108156 14450 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis 11689 16993 19225 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I 75986 242669 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II 12651 68671 99712 75320 28042 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis 107239 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 171567 75533 18103 79059 21915 56520 54369 22169 18102 66588 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis 11687 11684 625249 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) 23923 209027 19193 209692 12971 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) 77042 15586 74468 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis 22173 ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis 11972 108664 57423 66144 66290 11958 11957 11964 72325 11966 100039636 11947 66335 11973 11949 11974 230649 73834 17705 11946 114143 66043 11975 11950 100041835 432676 100039108 246782 228033 227112 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation 14287 270685 108037 108156 20425 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis 236539 100678 56433 107272 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I 104816 66514 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I 16365 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 231327 237823 14450 PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I 22245 68556 72269 80914 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis 74754 13360 235293 170738 14137 16987 14593 13595 110196 20775 319554 15360 192156 100040592 17855 15357 68603 18194 15490 73166 98386 110446 110460 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III 18263 11847 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation 72269 22271 76654 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis 15356 110446 15360 69772 71911 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation 68631 67880 58810 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis 18796 107650 18797 18798 18799 72469 18795 18802 74055 114875 18717 84095 269437 18803 234779 18718 52858 108083 18720 18719 67073 117150 224020 227733 269615 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV 68738 60525 11669 12359 11671 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) 13106 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation 12040 66885 12035 12036 15108 110446 13171 110460 13382 93747 12039 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis 11611 268782 ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 76267 56473 74559 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis 20450 20449 22234 14595 227671 14421 20440 54613 53625 14344 93961 14343 20451 57370 53418 20454 56375 108105 239559 26877 54218 26879 20444 56386 20443 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I 109778 394433 15369 15368 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III 27388 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis 56375 108105 56386 20443 20450 22234 14595 20440 54613 53625 20451 57370 53418 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 75540 234730 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 218138 THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III 29807 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation 64705 99586 103149 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation 66902 NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 192185 18115 CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation 110695 218865 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI 11534 PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis 12651 67420 68671 55979 12660 13026 14712 228061 99712 236899 75320 407243 28042 330450 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis 22173 L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 98256 71562 70789 266645 237320 107766 70266 209176 15930 23923 229905 56720 14719 209692 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) 13075 15490 13087 15487 15485 114664 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 74559 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation 211389 HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis 15186 GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis 20454 20449 22234 54218 14421 20440 20444 56386 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide 80908 26877 14344 93961 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III 11677 13106 67861 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis 11720 232087 108645 PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation 18606 68255 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis 171567 22247 69719 75533 56749 51797 55936 18102 18103 79059 56520 54369 22169 66588 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 69718 217837 75678 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis 108037 20425 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis 20249 171210 171281 171282 328035 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis 64292 67103 19223 19215 54486 77219 21391 15446 12408 100043508 19224 96979 19225 105349 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation 83493 72519 19062 320634 104015 16330 64436 16331 269180 16332 234515 234129 20975 101490 97287 19211 219024 74302 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis 106529 83603 56348 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) 71743 106564 66812 RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis 11687 11684 71932 11689 625249 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) 81906 13087 13106 71519 74134 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis 23887 64292 11687 67103 17001 19223 11684 19215 14865 54486 11689 77219 625249 21391 13479 15446 100043508 19224 96979 71932 72054 319446 13110 16993 106648 19225 56448 11688 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination 18602 18600 18599 18601 242726 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 18478 PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II 27388 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis 228550 320404 69718 19062 212111 320634 104015 16330 16331 16332 233011 20975 17330 19211 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis 76500 69718 227399 327655 75678 271424 27399 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism 107585 13371 13370 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway 50493 232223 26462 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis 11689 19225 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate 104112 KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis 67041 110446 69772 71911 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation 67689 66681 11670 72535 232449 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation 11687 11684 11689 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 12116 238505 64918 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation 107141 81906 13087 13078 13077 71519 74134 18984 20887 17161 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 266645 237320 209692 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions 14776 14775 67305 14782 625249 14778 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage 74080 226518 66454 59027 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation 76507 140483 CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis 67512 55979 110911 67216 102247 14792 74596 77582 14732 231510 52123 67469 28169 215456 68262 99010 225010 218121 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt 17330 12183 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III 338521 56794 11671 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis 14120 100043349 12183 14377 18655 21991 18663 68401 18648 56012 13806 18563 17449 17448 11676 14751 14121 13808 14447 13807 11674 230163 18534 14378 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I 237940 11669 17161 109731 11754 11671 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 66646 19895 21351 21881 VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II 106529 54325 56348 74559 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 76267 56473 20216 68801 233801 26458 56348 272428 94180 328845 14081 74559 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 69718 217837 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle 23887 68252 14630 66054 75475 14629 14854 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I 51797 55936 66566 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis 212032 15277 15275 110078 110095 19309 216019 66681 103988 232714 72157 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation 12040 268860 12035 227095 12036 66948 58875 13171 104776 13382 93747 12039 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) 231713 235606 67877 76773 11907 18203 56307 75624 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis 11689 19225 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis 76615 14718 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification 17766 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II 212032 15277 15275 216019 66681 103988 72157 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II 17161 TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II 98404 66078 68045 66637 76265 28088 104721 68215 67106 381802 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage 21877 22171 72269 13178 57813 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 75533 110074 21915 382985 18102 18103 79059 56520 54369 66566 20135 20133 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis 56454 69051 209027 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification 100042314 14859 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation 100042069 23917 107569 23959 230718 76952 11486 22436 18950 14544 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis 107869 11720 232087 269378 12411 108645 L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle 66902 11720 232087 104923 108645 20810 70266 67870 67873 56369 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation 20975 114663 242291 101490 55980 19062 212111 320634 104015 16330 16329 16332 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation 66885 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway 20481 218441 11480 12167 12168 12156 17128 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis 23887 17001 14865 11689 319446 13479 16993 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis 15497 15492 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis 14661 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II 19662 19659 22436 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis 14630 14629 14854 DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation 12846 17161 109731 11671 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis 11687 11684 71932 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I 76615 14718 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis 20454 53897 22239 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I 20322 PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate 16833 16828 16832 PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III 67689 11670 72535 11669 20229 17161 69215 109731 11671 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis 12716 12715 12709 76722 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) 60507 106248 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation 208982 15356 11992 72039 56357 12040 12035 12036 13171 13382 12039 78038 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle 14555 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation 104816 66514 11593 14718 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation 20887 11669 17161 11671 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis 11565 11564 11566 78801 11636 11637 229949 68870 635960 56248 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis 56360 70025 170789 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II 225845 66727 27281 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 98256 71562 70789 107766 209176 15930 56720 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis 67883 22235 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases 18796 18797 18798 18799 72469 18795 18802 74055 225845 66727 114875 27281 232889 18805 18806 269437 18778 18256 18803 26971 329502 234779 67452 271844 104759 237625 26970 665270 53357 26565 18783 18784 18782 18807 78390 66350 269615 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis 14137 20775 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis 78925 94224 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis 14630 14629 14854 14718 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis 71743 106564 66812 75735 211347 74450 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation 11676 69983 16548 225913 11674 21991 230163 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis 75456 19139 110639 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 22171 171567 75533 21915 18102 57813 21877 18103 79059 72269 13178 56520 54369 22169 66588 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis 12651 12660 13026 99712 236899 212862 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization 78914 74080 226518 98256 66454 58810 71562 70789 266645 237320 107766 209176 15930 56720 13195 209692 21990 11298 216343 13087 110446 110460 93747 20887 270076 11671 107141 81906 13078 13077 71519 74134 18984 11669 17161 109731 67375 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) 11430 113868 93732 20280 15107 15488 26458 74147 94180 15108 328845 93747 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine 58810 13195 109731 11671 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging 212679 70560 27267 23874 224805 71984 226414 85305 97541 70791 22375 216443 234734 107271 20226 15115 105148 68915 230577 226539 69955 71941 381314 107508 102436 67417 109093 110960 70223 22321 353172 66590 272396 71807 244141 104458 70120 107045 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage 216134 103711 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I 245847 67980 26384 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis 234724 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage 171567 75533 382985 18102 18950 11486 68870 56248 11821 15452 11565 100042069 23917 14923 11564 11566 18103 79059 11534 78801 56520 54369 11636 11637 229949 20135 635960 229363 20133 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) 93898 70750 104725 20773 13244 268656 228677 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 22171 171567 75533 21915 382985 18102 18103 79059 320685 56520 54369 66566 20135 20133 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis 171567 75533 51797 18103 79059 56520 55936 54369 22169 18102 66588 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine 108037 110695 20425 218865 74129 12116 TCA CYCLE%BIOCYC%PWY66-398 TCA cycle 20916 20917 11429 67834 18293 13382 66052 67680 66925 17449 17448 66945 170718 14194 78920 12974 15929 56451 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis 68327 14791 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation 20280 15107 52538 26458 13177 231086 94180 15108 97212 328845 93747 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis 93898 70750 104725 20773 13244 268656 228677 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) 74559 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II 20322 11522 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis 20454 108105 22234 26877 20440 56386 14344 93961 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation 257635 TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling 72562 13180 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis 20810 TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis 14528 20751 19286 L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) 98256 71562 70789 266645 237320 107766 209176 15930 56720 209692 110446 110460 93747 270076 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation 108155 76055 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis 15159 RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I 19662 19659 19378 11668 242285 216454 56847 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 20450 80908 14595 20443 76969 14348 14343 57370 53418 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation 171567 75533 18103 79059 56520 54369 22169 18102 66588 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation 72269 64705 99586 22271 103149 76654 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) 107585 13371 13370 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis 14595 53625 72077 14538 57370 53418 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) 13177 23986 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis 100043349 103988 212032 15277 15275 216019 18642 18770 56421 18746 18641 12183 18655 21991 18663 18648 56012 13806 11676 14751 13808 14447 13807 11674 230163 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) 107869 12411 HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis 56375 16770 14595 50935 20440 53625 14344 93961 72077 53418 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation 100042069 23917 23959 76952 22436 18950 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 22275 14151 19044 12892 MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle 78070 12896 57279 12895 12894 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis 22178 13190 22173 22063 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) 71147 223722 257633 70316 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation 14073 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) 11532 13885 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis 22234 239559 227671 26879 20444 56386 14344 93961 14343 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation 212032 15277 15275 58866 103988 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis 71932 13850 384214 13849 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) 77974 19771 19662 235033 19659 17252 241452 19892 20148 79235 98711 19660 19682 19661 28200 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis 15497 78925 94224 13074 15487 105349 15492 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis 100042069 171567 23917 14923 75533 18103 79059 56520 54369 18102 229363 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis 77974 19662 235033 19659 17252 241452 20148 79235 98711 15450 104158 67935 234677 63857 436059 69060 19660 28200 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis 11687 11684 71932 11689 625249 19225 56448 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis 107650 103199 18706 74769 18707 18711 18717 84095 104709 83493 75669 320207 52858 108083 18704 240752 18705 225326 18720 18719 67073 18710 30955 18708 18709 224020 227733 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II 212032 107652 15277 67980 74246 15275 26384 109785 54342 216019 14751 103988 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I 268860 214579 CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis 216019 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I 12583 14718 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis 170439 26458 70025 56348 94180 328845 14081 171210 171281 171282 74559 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation 268860 TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation 212647 56189 67432 14719 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation 106648 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 56473 54326 68801 56348 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis 16987 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 56632 67103 26458 94180 433323 328845 171168 14081 81535 54447 230379 11886 20698 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 66681 11486 18950 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation 72962 72269 22271 76654 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism 18796 269437 18803 234779 72519 18718 18797 18798 18799 72469 18795 97287 18802 117150 74055 219024 114875 74302 269615 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis 77337 83702 78925 94224 105349 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis 671878 FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I 270685 108037 108156 216188 17769 20425 107747 665563 17768 100039707 238505 GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation 14626 14933 235533 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation 110119 L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation 11720 232087 269378 108645 ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III 15452 11486 18950 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation 69590 14776 75512 14775 67305 20656 667310 12359 14780 14778 20657 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation 107569 23959 230718 76952 11486 22436 18950 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) 81906 13087 13106 67861 71519 74134 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis 56752 170442 192289 20425 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) 228550 320404 69718 19062 212111 320634 75678 104015 16330 16331 16332 233011 20975 217837 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis 11687 11684 11689 625249 11688 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation 69060 18947 16891 231871 16956 67717 15450 16890 116939 12613 66853 269060 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) 94181 12764 50798 67311 CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis 74451 66586 66461 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation 12846 CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis 14431 67092 UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) 22235 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis 270198 319801 18639 18640 170768 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis 14593 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) 22171 108037 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 78914 74080 226518 66454 67375 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis 70383 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I 24018 67897 DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis 12408 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I 19210 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 56473 54326 68801 56348 74559 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I 74246 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) 20450 14595 20440 53625 20443 72077 14538 57370 240119 53418 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III 13106 68738 60525 11669 11671 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II 68738 60525 11669 11671 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation 66904 17850 73724 110821 12040 13171 13382 12039 LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III 226413 12091 70893 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV 81906 13087 71519 14262 74134 55990 11761 14263 394433 226564 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) 74246 66681 319625 14430 14635 72157 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II 212032 14584 107652 15277 15275 109785 54342 216019 14751 103988 14583 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis 76282 108682 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis 11564 67054 108147 L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) 30956 110695 23923 209692 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis 214580 20768 109079 20226 211006 71984 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation 117147 26458 16922 56794 11671 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis 14645 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis 14593 110196 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis 68591 WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis 100929 329504 209584 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I 18778 18606 66727 27281 242864 56209 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation 66885 117147 110446 110460 93747 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis 78914 74080 98256 226518 71562 66454 70789 107766 209176 15930 56720 67375 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation 26458 94180 328845 14081 74205 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) 22117 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis 114874 18795 231871 269060 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) 11832 20531 64008 20516 20515 67768 20525 67674 18950 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation 81906 13087 71519 74134 13088 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation 11532 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I 66681 216558 72157 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis 11689 16993 19225 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis 56454 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation 23972 23971 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis 331026 14751 29858 54128 110119 69080 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 UREA CYCLE%BIOCYC%PWY-4984 urea cycle 11898 109900 227231 18416 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) 108037 20425 74129 12116 SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) 211389 59010 22117 HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis 22275 17025 14151 11655 19044 11656 12892 15288 22276 PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I 66904 17850 73724 110821 L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation 12040 13171 13382 231691 257635 12039 GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage 15452 18950 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle 11898 109900 18126 18127 18125 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation 12040 13171 13382 12116 12039 238505 14718 64918 211389 66904 17850 73724 110821 11720 107869 12583 232087 269378 12411 108645 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis 17025 11655 11656 15288 22276 MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway 68603 110446 319554 110460 15360 192156 100040592 17855 15357 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II 211488 106564 14261 ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) 93692 14873 DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis 55979 67916 216152 13350 19012 231510 50784 52123 67800 67469 68393 28169 381925 215456 229791 68262 235044 99010 225010 218121 67512 67216 102247 14792 77582 14732 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis 54391 319945 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 17330 69718 217837 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis 13166 18948 13195 21823 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 100929 209584 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I 246277 12583 14261 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I 11821 MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 17449 17448 14718 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor 75788 12393 76630 19877 17977 72183 18519 15529 18744 12447 57258 17222 16478 66313 20481 20482 56440 12530 67804 20682 20692 56484 20742 26409 21417 21781 211586 26413 21808 26417 21809 21812 26419 21813 216080 100041766 66105 22337 26416 103573 76793 227720 75465 67068 54709 52563 217232 69150 11909 69957 14106 12234 12442 230597 12505 24136 218210 56458 26399 21803 21814 18751 18752 17869 12928 11651 216869 11835 11848 26397 11910 19650 19651 17126 17127 18708 18709 12927 18753 14083 12566 20869 22062 22059 12387 13163 328572 13982 13132 71770 16842 433759 21402 15481 26965 16476 15239 17128 56438 68015 12567 12571 12575 68999 22601 66513 13018 26754 20901 218441 26411 71728 12534 12914 386655 19303 104394 14281 13559 13805 19645 23871 12443 14030 54601 14225 269338 14272 14282 20683 97064 12189 272359 99152 52206 15378 15405 69260 21815 16477 16211 17130 17131 17258 17260 12705 18044 18045 18046 18102 56513 56371 59008 56317 228026 18854 19042 71978 19085 19087 75901 12389 BDNF%IOB%BDNF BDNF 18212 26419 18803 23939 56637 26420 110157 16367 20416 13712 19229 271849 384783 18211 56484 26413 26417 11651 CCR1%IOB%CCR1 CCR1 26416 19229 18753 12913 14083 12768 18033 19697 19303 20302 20303 20304 20306 20846 22637 14675 20779 26413 26417 LEPTIN%IOB%LEPTIN Leptin 16367 384783 54611 18754 26413 20528 13649 26417 20218 16452 14784 20683 20848 667739 17979 19247 16453 192157 26416 16410 16419 16846 18708 16847 18709 18753 14083 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin 20848 56484 20416 233871 26413 17480 14388 26417 20851 16452 26395 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor 19273 71520 15461 67296 114715 114716 14936 16197 20662 56150 17179 17311 17342 21682 215280 22612 21933 54607 16590 56468 67300 15162 12703 20850 12984 14159 14191 26413 17096 12928 11651 26419 26416 18708 18709 11909 328572 16476 18751 18803 56637 110157 20416 19697 20846 20779 16452 14784 667739 19247 16453 20851 12929 13448 13685 56717 16331 13857 11350 14360 218397 14786 20111 18706 22376 58194 12402 208650 18750 CCR7%IOB%CCR7 CCR7 26419 12631 18803 56637 26416 19229 19697 56717 56484 56458 26413 12775 26417 11555 100039973 11651 100038965 WNT%IOB%WNT Wnt 22612 26409 11651 216869 26419 18504 19045 11848 18099 23988 22417 19052 18747 84095 320790 77578 20377 20319 18753 20664 22408 22413 22415 22418 22421 12387 14367 14365 12005 14362 14366 93687 16842 14368 21413 14369 14370 14371 16476 18751 18719 18752 84035 330938 21416 22416 84505 56637 12571 606496 19353 16480 54401 226970 13016 17125 13728 13542 13543 13544 13380 208846 67943 20378 231103 14734 192199 11789 12550 12443 16202 16971 16974 16973 18019 26563 26564 18750 FAS%IOB%FAS Fas 224105 50873 12362 320795 19877 11746 19090 12369 19106 66593 12370 72322 12028 12048 19687 20230 12122 12169 20807 56274 58231 12229 21454 12537 21841 21843 22029 22030 22031 26413 74153 22390 26417 12380 12366 12363 12368 223255 26430 56041 100042807 192656 14082 12633 17999 17193 26926 21945 98488 217232 26885 15170 16818 109333 56637 26395 14360 218397 17096 11651 18753 13163 93687 19353 26396 12043 17295 18810 22352 12367 11545 12371 19766 15507 333883 18570 19192 63958 66587 14084 27373 100039026 13001 67379 13347 21969 13665 75705 93692 11798 14102 14103 11857 17187 26408 15235 101706 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 22612 11651 11835 11848 17126 17127 18708 18709 18753 14083 22062 100039786 23844 12821 109620 13684 13844 13866 55948 16403 192897 16418 16773 16774 16776 16777 16779 16780 226519 16782 16785 19353 16367 19882 18479 20416 54401 74769 18707 30955 59079 384783 12015 20166 22627 22629 22631 18710 213435 18208 12476 20779 13649 14784 17295 18810 19247 22352 12367 13685 56717 11350 14360 18706 18750 NGF%IOB%NGF NGF 12912 327826 18759 13712 83945 26413 26417 26395 20683 HEDGEHOG%IOB%HEDGEHOG Hedgehog 22627 13363 24069 19014 75050 19206 15245 20423 319757 216869 19207 117606 70208 59024 110355 13548 18747 69792 264064 100041953 14451 269209 14632 14633 14634 16147 12387 GM-CSF%IOB%GM-CSF GM-CSF 12934 12465 14376 14827 59013 12051 20525 20740 22350 22612 15162 20850 12984 14159 26413 17096 26417 11651 26419 26397 26416 18708 18709 12927 15170 26399 21803 21814 18803 56637 606496 26420 110157 20416 13712 12015 19303 12912 20846 16452 14784 26396 20848 14388 20851 26395 12929 23921 19264 20112 22324 56324 14694 20844 57320 12675 16150 18643 18035 11757 12402 12981 20963 18750 12982 CCR9%IOB%CCR9 CCR9 26419 56637 26416 22350 225825 12769 16401 16421 17698 19684 20300 17123 12550 56458 26413 26417 11651 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 110157 26416 18479 20416 13712 14083 20851 26395 12169 18127 17973 13449 21687 21846 20850 14786 14159 26413 26417 11651 26396 CCR5%IOB%CCR5 CCR5 19229 19697 20303 20304 20306 20846 12774 11576 20850 26442 20293 20292 26413 20296 12273 26417 12504 11651 14784 20848 12631 26416 18708 15170 12675 16150 18035 20963 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha 16367 384783 20846 22637 20850 12928 20847 11651 226652 20848 20849 667739 15975 15976 26397 18783 18761 26398 20852 16451 13867 73086 54721 18753 20851 12929 13685 56717 22324 75705 56458 26399 18035 12402 TRAIL%IOB%TRAIL TRAIL 12362 19090 12369 66593 12370 12028 12122 18033 19697 21933 12912 26409 20779 22030 26413 26417 11651 12366 12367 11545 26416 14082 19766 12633 16151 26926 71609 50883 13030 12070 100039026 15270 11783 12387 27056 17210 11920 18383 670717 12018 11798 22333 65111 22035 18035 12042 105787 12402 NOTCH%IOB%NOTCH Notch 18519 26413 26417 17127 328572 16842 433759 21402 26965 15205 21423 11820 17128 20602 56438 13389 16449 14357 56637 14199 16396 56381 59287 15213 140484 13388 17125 15182 19664 16450 16848 18033 17305 19697 18128 18129 18131 18132 18133 20466 18550 100039623 54485 50754 55927 433586 100042305 19164 16452 19165 16656 20848 19763 27401 21885 22632 208117 270118 18222 60406 66935 20185 103806 M-CSF%IOB%M-CSF M-CSF 20416 12370 19229 17342 20850 11651 14784 20848 19247 22352 14082 19766 18708 210710 12977 18753 12978 20851 14083 23872 360013 209446 19201 17444 16331 13429 16332 12402 EGFR1%IOB%EGFR1 EGFR1 12390 56455 109711 54366 11502 101320 29875 54126 22687 19134 73178 29806 208177 68481 53859 12702 232431 54132 13549 194590 66952 23942 14924 21873 225870 20970 98910 238130 17775 330914 26431 78388 50926 12928 11651 11848 26397 17126 17127 18708 18709 12927 18753 14083 12566 20869 22059 13132 71770 433759 16476 15239 218441 12534 19303 14281 20683 21815 12389 16478 26413 26417 26419 26416 56458 18751 18752 17869 18803 23939 56637 26420 110157 20416 13712 19229 384783 18033 19697 20846 20779 13649 20218 16452 14784 20848 19247 14388 20851 26395 12929 13448 13685 56717 11350 14360 218397 14786 20111 18706 58194 12402 208650 18750 15461 20662 16590 67300 12703 20850 17096 12631 606496 19353 16480 54401 226970 13016 12550 26396 12043 17295 18810 22352 12371 19766 333883 11746 17999 15170 16818 109333 12821 109620 13844 13866 192897 18479 74769 18707 30955 59079 12015 22631 18710 12912 327826 18759 110355 13548 20112 22324 56324 20844 18643 18127 17973 13449 20847 16451 13867 73086 54721 105787 11820 16396 13429 16332 229615 12606 72993 227753 18760 19211 234779 100040260 20971 22325 12558 11308 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 12568 14251 74326 236576 24063 24064 57783 21787 67938 57257 108100 12608 24105 20499 26405 229709 19765 20867 399510 56460 69710 232910 12757 73379 19261 12988 216810 13014 12388 218518 74256 244418 11771 13205 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 13860 13858 11657 11674 240753 13855 229285 26936 286940 14252 98432 224650 23943 209039 105782 22378 80794 14302 235406 228136 104831 20399 19253 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 232906 26934 11740 13854 16952 12306 15194 215114 15382 628438 11804 16337 16400 16412 11836 67859 11843 110308 16687 110310 16691 16667 16668 16828 11855 16835 210126 109904 26401 26406 26407 17709 17886 17920 18003 11928 23980 50932 20403 13196 11949 67941 50766 72621 18596 54135 72201 18607 11431 18648 240752 18738 18746 67451 18805 18806 22038 74155 67760 54473 109135 171463 212139 71889 216190 235542 74255 170643 321022 230837 108079 19084 26362 18762 66898 23938 26400 19108 208618 93742 66166 76179 140721 20459 19246 19248 19262 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 666899 667618 667279 110651 67097 20194 20195 20239 394252 20969 53378 140579 71514 56726 20404 20408 230126 319939 381126 114479 20617 107686 20663 109552 109880 20909 11491 22042 21881 21894 21961 22051 22323 22330 108705 66395 244895 640703 60595 24066 319152 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 72828 227937 107435 30794 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor 12393 12362 17977 12369 18519 12370 12447 12530 12537 56705 12572 107951 56424 17978 81601 108767 12539 217127 13144 56710 13195 14797 11622 104156 14200 56406 192176 56218 14375 30051 68098 75273 11739 98053 68705 14884 223870 19183 15375 15469 14828 15519 16195 56637 11863 75352 17246 53610 18813 18477 57314 59004 18986 101700 214230 328365 12017 57782 19697 170758 19384 19822 18193 77627 225115 21804 20779 232286 22025 22026 22027 13649 22196 22353 107823 22596 20848 22668 627557 12317 17979 268903 52915 22294 23957 56469 12445 66671 107321 56736 12531 14694 57320 11651 11835 19045 17127 18708 12387 13163 328572 13982 433759 21413 15481 16476 17128 20602 19303 20466 19645 12443 20683 12189 12367 11545 15507 21815 21969 229615 12606 72993 227753 18760 19211 12389 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 20848 14388 14255 14389 11909 12912 12606 20850 26413 17096 100040260 26417 12402 16476 208650 11651 CD40%IOB%CD40 CD40 26419 20848 26420 16453 26416 18708 26395 16818 14360 12675 16150 14191 26413 17096 234779 18035 26417 16476 20963 11651 17869 TNFSF3%IOB%TNFSF3 TNFSF3 19698 18033 18034 19697 21937 21938 22033 16992 17000 16994 22030 22031 18035 16476 ID%IOB%ID ID 21416 11910 19650 19651 13712 17127 12566 19645 13713 13714 15901 15902 15903 15904 17877 15205 17927 18507 21423 19185 G-CSF%IOB%G-CSF G-CSF 12576 12700 12985 12986 14319 16188 18778 19696 20416 667310 20977 107939 12702 20846 15162 20850 18759 26413 17096 26417 16452 11651 14784 20848 19247 26416 16451 54721 20851 14389 12566 27373 16818 16331 20111 12402 20963 EPO%IOB%EPO EPO 606496 110157 15163 384783 20393 12015 319183 18127 56484 20850 54601 26413 26417 16452 11651 26396 109880 20848 19247 73086 14388 20851 26395 12929 23921 56717 22324 13857 56458 16476 20963 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma 110157 15395 15900 15979 16362 16363 19094 20375 20846 12608 20850 26413 13649 26417 12928 16452 11651 26419 20848 18783 18761 26416 20852 16451 12929 234779 12402 TNFSF1%IOB%TNFSF1 TNFSF1 16151 19698 18033 18034 19697 21937 21938 22033 16992 17000 230979 22031 18035 16476 11651 TNFALPHA%IOB%TNFALPHA TNFalpha 320795 12369 12370 53859 12122 22029 22030 22031 12366 107951 14082 12539 12633 56710 100039786 192176 15519 22627 22629 22631 12912 22026 22196 19698 18034 21937 21938 22033 14694 12675 16150 18035 20963 12051 19696 14886 11797 15516 16535 100039592 16648 16709 17218 17220 11651 26403 76784 18036 18037 20018 18567 18616 18637 245841 100043714 67857 73086 19173 19179 16151 19181 18753 71609 19182 70247 21762 22123 17463 66997 23997 228775 19708 77045 67891 432502 27207 433759 57751 21402 80859 27215 26965 64424 16476 20586 20587 20588 68094 57376 21926 21929 22034 22628 22682 66513 231130 236733 26754 20017 224619 15182 18201 230233 26572 56456 12914 12905 21934 12455 70834 233406 53376 17164 19645 211550 50797 21941 50754 226525 67384 20016 22032 56489 73174 66413 23881 227648 216150 21353 15185 72416 71833 56399 544963 333654 18789 56532 26410 446099 17846 109658 11652 14113 211651 76589 19414 14229 68652 103583 18854 16650 11647 66724 20019 56407 56312 12389 12091 20340 71966 69721 56480 26409 26405 26413 26417 26419 100041766 66105 26416 13205 12234 26399 26420 18033 19697 20846 20779 13649 19247 14388 13448 26401 26406 20850 18762 23938 666899 54401 13728 12367 19766 15507 14084 100039026 GDNF%IOB%GDNF GDNF 17295 19713 21823 110157 12532 19229 110651 12927 14388 14083 12534 26395 13448 19303 14360 18035 16476 12928 26396 TNFSF8%IOB%TNFSF8 TNFSF8 18034 19697 12051 19696 22029 21941 26413 22031 19698 11651 18033 CXCR4%IOB%CXCR4 CXCR4 14674 13983 23880 14677 26385 15894 16414 16428 16822 16885 12778 17973 20315 21785 22329 12767 56484 59025 12774 26413 17096 26417 12928 20847 216869 20849 12631 11848 26397 18708 18709 12927 18753 14083 15170 16818 15481 18803 56637 19353 54401 13712 19229 12015 18033 19697 19303 12912 20846 22637 20779 13649 16452 26396 20848 667739 19247 16453 20851 26395 12929 13448 19264 20112 16331 22324 14360 218397 12675 16150 22376 18035 234779 100040260 20971 12402 22325 208650 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 19225 18021 54720 16476 640703 56398 18018 18019 14281 104248 12981 16184 16183 15978 14103 53901 21947 381319 18986 14283 238276 14225 16477 16189 18747 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 16476 20687 18519 12912 328572 17131 20466 14462 12567 226519 12566 228839 17869 15481 14815 20683 17977 75901 245688 19650 17978 14106 56484 17260 56458 16419 12579 21815 15378 13390 14836 60406 16191 12575 11835 12914 11909 17927 11651 15228 20467 20482 22337 20481 21781 13982 18091 15182 433759 13559 76793 104394 21423 15977 12843 94112 59004 17187 54601 14534 18787 17126 17127 17128 100041953 20185 12608 209446 22642 19646 12393 13016 11910 12399 16153 12400 54123 12705 229615 14281 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 16173 16171 257630 18033 18035 20846 21926 17523 20849 20848 209590 329244 12702 93672 16452 16182 83430 16176 16400 20293 18126 16174 12501 54721 17329 18708 19697 16161 16160 18706 11686 16193 12504 16183 330122 15978 20850 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 433759 56469 103573 208727 22196 19384 17344 17246 19386 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 18720 53859 16202 16476 57257 26419 19353 16416 26413 19878 26417 19229 11848 12505 12675 16410 17390 26401 18792 17395 227753 18033 18035 18708 19697 14281 18706 12927 20963 20750 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 17128 26413 17131 26417 21813 13001 17129 21803 55994 11477 11480 12389 11481 12168 11482 17125 19045 13805 15901 21909 12165 16323 216869 21809 21812 14225 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 16367 20779 14083 16476 76829 26419 19353 12912 26413 26417 11848 17973 19247 20662 18708 15461 14573 14783 14786 18706 13448 14784 623279 12928 58234 18750 19713 14388 384783 20416 327826 19303 109905 12927 14585 114255 18747 218397 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 20969 12833 12832 26413 12215 12815 26417 12814 12831 94216 12830 83995 17393 15234 12361 20304 17395 14170 17295 12829 12828 12826 21803 12825 12824 64654 15442 12842 19035 16776 53378 14186 12836 12835 14184 12834 12843 18747 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 18754 240057 18176 16854 240168 56715 18015 640703 20662 18751 15461 54153 19395 12323 16852 225870 14784 18762 233046 74055 69601 18750 20663 20130 19415 19419 114713 19417 19418 16653 218397 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 20877 625328 16319 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 12703 20292 16186 16451 16453 12048 16416 15361 16165 16164 16992 15170 17863 16331 17864 20295 14159 11687 16190 20683 23871 56717 12053 18703 13449 16364 26416 245195 20344 20375 13654 18390 14128 21786 56468 21838 11846 16191 66596 11628 20851 12402 547253 20852 11651 14784 384783 12843 20416 16367 12608 16153 12842 12702 16452 18708 18706 20850 21947 16189 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 16186 16451 16453 19353 12048 17863 17869 56717 18033 56484 11651 15519 19247 16185 640703 20662 667739 18708 20597 19697 12043 16818 13669 18706 21752 14784 18762 22234 16184 208449 16183 14389 13555 20416 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 16186 16451 16453 11848 19247 16185 20662 15461 16818 14784 14389 232906 16001 14388 16000 107971 20416 18127 327826 18049 21687 18591 16911 16195 16194 16367 11600 22339 14677 15979 13645 18205 78405 18596 17356 94212 13649 15529 16542 110157 18211 18212 18213 14679 12064 26395 26396 20846 16452 18176 18708 18706 16193 16184 16183 15978 16653 18747 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 54720 20185 328572 12393 13016 17863 16542 17977 225182 14465 108058 14463 15251 103806 20602 20848 56381 22160 11545 12576 15214 16452 18128 11863 17172 22632 19645 11835 21885 12914 15205 19213 17927 14600 99982 14387 19664 14460 55927 15213 270118 11925 12504 433759 13555 21423 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 16420 16398 16421 241226 16411 213119 16416 16412 16414 16410 16419 16400 104099 381924 16407 16408 16409 16399 320910 16401 16403 16402 16404 319480 192897 109700 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 19046 19878 18817 228730 236930 11848 17931 20878 22390 19324 218294 269582 229841 72119 103733 99412 67141 107995 72415 20843 12531 67629 13605 12532 12235 56371 12234 16563 19348 19052 51792 100043703 18479 74498 78177 233406 71876 103583 67052 12534 18221 77744 12236 16319 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 17535 22195 18538 27354 22059 235559 100040608 12021 72775 19361 12566 225182 66105 22596 211651 14088 14087 14030 67030 11920 14375 12189 67337 60534 12447 19360 19090 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 14679 14677 14687 94226 11848 14673 14681 14678 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 20779 12912 18211 55948 54401 18753 22065 193034 216439 12015 12443 18803 12326 56484 13653 12322 100039786 22628 22627 22631 22629 18607 56637 18176 11651 20662 18708 15461 18706 14784 20850 14388 20416 18049 16653 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 16476 26419 16173 21803 20849 20848 16182 14969 14968 57765 12500 12502 12914 16362 16174 12503 12501 18646 16163 104156 12487 12519 12524 14281 26420 16184 12504 16183 15978 17344 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 22352 23980 215387 67455 71819 16765 19047 28114 21770 107589 242521 11848 20878 72415 12235 19348 67052 26554 70099 19167 14211 12419 11799 52276 54204 26934 12615 13346 320165 14020 20877 68298 625328 73804 218397 16319 18148 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 20779 14083 19353 26413 26417 11848 18208 17909 69635 13176 330662 107449 14360 22612 26395 107448 216439 26396 73178 18738 17755 18803 22253 140580 223435 12322 18479 17973 18708 18706 12927 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 14677 26413 26417 14687 11848 94226 14673 14681 14678 14679 18803 13611 14674 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 26395 26413 30955 18576 104709 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 19225 328572 20466 14462 17863 17869 15481 20683 23871 20375 18712 68652 11906 11486 545878 12575 12490 17217 12914 67155 17311 17927 12418 17120 12571 21426 15461 17132 12043 14863 20481 56463 12757 19374 16841 19152 12346 66513 12368 232087 18507 26409 12843 22761 17878 12578 16842 23872 67738 16790 15258 67972 11796 12978 20185 16590 12608 12847 11541 19208 51788 50701 12427 21849 18099 29875 18674 64050 19055 229615 12609 12606 22408 12443 17523 12576 18176 15205 14460 12504 22196 16653 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 20779 14083 19353 26413 26417 26395 13845 73178 13844 270190 22041 104015 13429 215449 13643 13642 13641 13640 16443 26921 545156 19877 13846 18176 18479 17973 18708 15461 14786 18706 14784 12928 20130 20416 19303 109905 16653 218397 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 20779 11796 26419 12675 26401 26416 18607 14082 19687 12229 14102 67300 11651 12122 12367 22350 18708 20597 16150 72393 74769 26420 26399 18706 26400 12370 16151 19766 19094 14103 11797 26414 12633 20963 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 20873 20620 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 21937 114774 11796 67384 18590 26419 13645 228355 229317 26926 26413 12028 58994 26417 18201 11886 26398 13033 110157 670717 12905 17869 26401 18753 26395 26396 18033 12015 18035 21926 26921 14082 19645 11651 12122 20597 19697 12043 18762 12370 19766 16000 56632 71609 22030 23992 19106 16706 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 20779 22195 21770 19229 14773 21823 18796 18753 14360 17096 22612 19144 15162 50873 12015 12143 30931 67847 57320 22223 13162 56424 100039026 14191 20617 18805 18806 109731 16818 14225 20963 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 12234 20779 12051 19696 216869 18708 16150 19697 16818 18706 18033 18035 26416 20963 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 18720 16476 26419 16412 19878 11848 26398 17931 12576 18805 18806 19877 105243 320795 109333 11909 20404 320271 14064 22350 18719 20807 22330 20544 14281 26399 56513 11459 18762 29857 21894 12631 16007 223701 19211 18717 19684 17698 13367 17906 16885 12704 16886 26397 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 16416 11848 14360 22612 17096 15162 12143 12389 14191 20851 11651 16818 13448 14784 12928 20416 18591 16367 12977 20779 64177 19246 12978 12991 13645 12988 14131 12333 18596 50490 19116 24064 13649 16334 16846 16847 16797 19109 14158 22166 16337 12558 22608 20848 12702 16452 54721 18708 18706 20850 16399 12927 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 20779 16398 26419 16412 26413 12028 26417 11848 15529 17390 12361 18753 14170 385643 13844 14268 60409 16774 21803 57916 269587 64654 16772 12390 14694 53378 14186 14184 18015 12367 22350 15461 12981 18747 218397 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 320139 18176 26413 26417 18751 15461 110157 14281 26395 18750 16653 26410 109880 13712 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 16476 26419 12048 12912 328572 26413 26417 12567 17390 21823 18792 26416 11846 11909 12043 13982 18750 12189 16334 11910 12400 12443 12702 20724 21808 83430 20174 18218 19017 19645 63953 18126 18595 15205 26914 20339 18015 16478 81703 13008 15132 12123 14281 26420 12428 26554 71355 81601 16193 19252 240672 15978 19094 13198 11423 13197 18986 16477 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 13837 20779 13835 13637 57257 13636 53972 13836 13638 11848 14360 17096 22612 15162 12143 18803 30955 104709 13640 14191 19877 12402 16818 12928 442801 12568 12929 13842 13840 22325 13841 13839 13838 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 21937 18519 328572 68346 17131 75387 20466 14461 27374 56233 15185 23942 15184 30795 64384 75788 70465 93759 216848 245688 232232 19016 17191 107932 64383 21422 22025 170787 229512 70315 50721 12234 209011 234366 60406 17119 79221 15183 229542 12914 17192 20467 15182 433759 22761 17187 100041953 20185 19646 18033 18035 21926 20602 20848 22632 19697 14460 103573 208727 22196 19384 19386 18747 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 18102 16398 105504 20528 241226 211446 213119 16412 16334 16410 18805 18806 16400 216859 67300 211914 12876 53413 70834 22319 30948 11555 12000 12387 20336 104099 30957 69940 12550 56044 107371 18717 16593 22095 16401 12385 16403 11845 16402 11607 16404 12388 319480 66482 13430 109700 24044 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 26419 93687 18519 27401 214897 328572 64143 19651 18817 12359 20393 20656 15235 12566 12675 252870 14377 55948 22682 54401 67731 12125 70425 93759 103236 12053 27373 104318 56484 56458 100039786 22628 22627 22631 12576 22629 12914 11651 16150 26420 12387 14103 56044 103573 26414 13197 19384 54601 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 14676 14677 14687 94226 14673 14681 14678 14679 14675 17250 81535 14739 13611 56632 14672 14674 14682 20397 20698 13610 13609 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 20779 20528 12048 12675 110157 55948 54401 56717 12015 56484 56458 100039786 22628 22627 22631 12576 22629 18607 210789 56637 78757 16646 56716 12575 606496 12371 23797 227743 11651 15519 11652 26408 54601 18747 19090 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 18102 20779 16421 19353 17356 11848 29875 12443 215449 11651 21872 18708 76884 107746 11767 13383 18706 12387 242687 21844 226541 12928 16480 16407 12550 13043 50884 11308 18717 12385 11845 109905 22325 12388 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 110355 226861 21808 20423 19227 14451 13363 14633 216869 19206 11651 18708 18706 57810 16976 15245 117606 19207 14725 20460 16147 319757 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 20873 12795 18817 20620 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 18720 16476 26419 19353 68089 67771 26398 26403 11867 56378 66713 74117 26401 11855 224105 18796 13058 241275 192662 13057 108100 101314 26416 17970 76709 83767 329165 71893 17969 237038 404710 18479 11909 18719 12387 12928 12631 12550 18717 12385 16885 26397 29875 20848 76884 26420 26399 26400 242687 20850 50884 11308 26934 12927 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 14686 12790 76376 19682 245650 243923 14695 77974 30952 78600 14697 170735 107477 14913 24013 19892 19739 79235 110855 14710 14919 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 18102 20403 73341 227377 57257 109904 53972 219140 319899 216963 75974 11789 192662 18803 16443 70497 210293 236915 26934 29815 54126 19765 52666 22325 71972 228359 17207 14163 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 22339 13636 328572 14254 17387 67923 18655 16542 112407 112406 20525 26357 11792 22346 20683 23871 16341 93759 20893 18999 17684 18174 13856 13819 14297 319594 11540 22160 13712 11863 12914 18787 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 16476 26419 18519 328572 14461 26398 56233 14815 17977 93759 17978 26416 56458 22025 19696 11835 12914 67155 320795 15519 433759 20779 12606 13653 14694 20588 11614 52915 217127 59035 56637 21848 18585 30051 20181 20183 20182 223870 22026 66884 57376 50528 15408 110147 26399 68098 15502 81601 18986 17246 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 16451 16476 18595 20662 18708 20807 107746 16410 14281 18706 230126 14784 435684 12391 12928 18803 12929 20416 12389 100039026 13712 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 20779 14184 13649 12361 14360 14170 20970 13043 18976 19164 11604 17202 100042305 64654 13004 59287 19242 208117 100039623 14186 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 100040260 19225 102626 271457 73389 16476 17165 22059 12608 18783 12912 17164 15507 13714 14567 17346 17258 13685 16691 13684 17342 56613 226641 73086 26416 17260 19017 18126 11909 20544 13982 19094 13198 22278 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 20779 14083 19353 16412 216963 19229 330662 12475 67374 14268 17242 12520 17882 270152 21825 19084 21826 19085 22329 140559 22631 19262 18749 13522 21894 12928 11308 16401 11845 19303 12927 18747 20750 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 22408 73016 84035 14367 192199 26564 70495 13380 16974 14362 22415 14366 22416 16973 22413 22418 14370 68588 22422 14371 22421 14368 24117 14369 57265 16010 20187 93897 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 18021 16476 12912 328572 14461 17863 17869 21823 14815 18792 20683 17395 23871 21803 16191 11909 17132 12534 13982 11459 12387 16007 19211 12843 12578 230899 21416 17134 67405 26754 14284 382056 22059 14282 13614 22051 23857 13709 12017 11770 11910 17750 13406 16153 83995 21857 12400 18619 11606 15007 12125 14609 12443 15251 13653 12576 20293 16478 18018 18019 14281 12981 16193 19252 16183 15978 14283 16477 16189 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 16452 16191 20851 19247 18708 18706 14784 17096 12700 16192 12984 20850 53378 18712 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 73341 16202 16476 19353 12912 17931 20878 29875 64099 21961 12443 12539 76142 56212 140579 18938 170736 57342 11545 26431 67268 56505 22793 56637 78757 17974 20174 75786 21335 68458 67444 225341 21417 11651 15519 20613 109711 12387 103573 54126 13367 19303 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 19246 26419 19353 11848 14158 14609 12558 227753 18803 19877 19247 640703 12005 18708 14800 16573 16973 13191 12325 18706 12387 231871 14182 12801 16480 14432 13043 13589 269060 18717 12385 17906 12388 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 218772 19411 19401 20186 22260 17977 19016 21803 21926 20602 20181 20183 20182 22337 12043 22259 20787 11303 19015 19014 67544 21834 21833 19013 15370 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 22061 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 16476 69191 328572 24068 18996 18997 12266 22433 13033 116870 12675 22200 15500 17869 11764 18002 11785 11957 17977 78330 13508 27410 23957 17978 55960 268395 18667 268527 12006 22192 66949 224903 12822 71990 667310 12521 211329 268903 11737 17979 13983 114604 100041004 67488 212391 12034 671392 67040 13982 433759 12189 16911 17128 18538 20185 12608 19109 12443 20602 11614 20850 208727 19014 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 26419 19353 16412 26413 26417 17390 14159 14360 23871 13449 26416 56458 18806 12575 20851 18479 11651 17973 19247 14786 18815 14061 14784 11601 11602 12928 231130 69257 50915 14173 12169 20416 18127 19303 21687 11607 218397 11600 14083 13709 14268 18033 21926 13712 18708 19697 18706 20850 16402 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 18021 16186 16476 26419 26413 26417 16185 15461 18750 13656 14939 21936 22163 21942 230398 12010 18761 12525 12526 15976 15975 13813 110157 15007 26395 26396 21926 13653 20849 109880 13712 320139 18754 12500 18176 12502 12503 12501 18646 640703 18751 18018 18019 14281 26420 16184 16183 15978 14103 14283 16653 16477 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 16476 26419 19353 16412 26413 19878 11848 26398 16410 330662 14360 23871 22612 73178 140580 16419 18479 17973 20662 22330 14786 11459 14784 21894 30957 12928 232906 12169 54126 19303 109905 218397 20779 14083 71302 213498 245671 110596 13196 20405 24000 12334 110157 26395 12443 18803 215449 109880 26431 17974 109711 18708 107746 26420 18706 20130 16402 12927 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 16777 16779 16774 16403 16772 226519 16780 16776 16782 192897 16773 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 17535 27354 235559 100040608 72775 69928 19367 19718 19356 69263 15574 67196 12190 235610 15270 12649 237911 330554 19355 74335 12234 101831 230484 21975 237211 71885 12144 208836 15205 104806 67561 68275 106344 103583 72151 233826 19891 211651 14088 14087 67030 11920 12189 60534 19360 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 17535 21415 72433 14284 26362 73389 56436 110308 22061 22601 64058 21973 15201 12442 12831 55948 12609 12190 14694 18128 56637 11486 16400 15205 22337 18987 20997 16175 16396 50754 14776 12062 16664 226849 13395 11920 107568 56437 16009 17246 12578 67815 14104 211323 20913 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 22352 21937 228355 12028 11820 11857 101706 670717 20740 12905 14453 57913 26401 20230 11783 12362 227753 12366 16668 12363 66593 12632 12369 20874 21418 16907 11798 13368 13347 16905 16906 21969 12043 11459 12368 14939 16885 14083 11796 21926 11545 12371 18646 12122 12367 12370 19766 11797 20787 71609 22030 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 73341 57257 109904 53972 219140 19353 319899 330662 192662 140580 223435 545156 216445 109934 16800 277360 24001 94176 110279 229877 23853 20662 13860 22324 21844 70497 11308 26934 54126 19417 19765 19418 52666 22325 228359 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 16414 11848 15235 17390 18792 17395 15162 67374 18033 17882 21926 215449 20344 21838 19877 15894 11596 18815 238055 20345 19882 16193 21894 14219 83964 434174 18791 16409 18793 16971 109905 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 18102 18720 18805 545156 18806 19353 26413 26417 11848 21844 18793 53869 11840 215445 11845 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 16476 26419 18783 26413 26417 26398 16331 12675 26401 14360 224105 17096 18806 12402 11651 19247 20662 15461 22324 13448 14784 14389 20416 19012 19303 19249 50928 215280 56743 218397 14127 14126 14125 14083 16822 15163 18778 14130 208650 16428 110157 16797 14158 26395 26396 18033 18803 20698 13609 12229 18751 18708 16150 19697 18019 14281 18706 26400 16151 19252 20963 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 20779 22339 14677 19353 26413 18596 14254 12767 26417 14687 11848 14673 14681 14678 14679 14675 14672 14674 14682 13610 14676 16452 23797 11651 18591 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 16421 14083 16412 16401 17123 11848 19303 22329 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 19353 26413 26417 11848 330662 140580 19247 20662 15461 14784 12928 14389 14388 107971 20416 327826 18049 109905 17207 218397 18205 78405 18759 100040603 94275 330914 18211 83814 18212 18053 18213 216148 17179 12064 23873 26395 20418 11350 19762 12443 19769 18803 67903 13429 56212 98878 215449 83945 20848 56470 18412 18176 18708 107746 18706 18762 21844 12929 19417 16653 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 20779 19353 16428 20393 11848 16331 16797 14360 17096 22612 15162 12143 18803 56484 30955 19157 104709 19159 14191 19158 106952 18607 17060 234779 22637 16332 11844 18176 12229 83436 101476 231821 15519 26377 18708 15461 16818 74769 18706 19211 11840 11845 109905 16653 20963 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 20185 22601 26413 19116 26417 19109 14360 68652 16452 20851 13874 18183 18708 80707 15200 74769 14812 11491 18706 13869 14784 13866 16396 12223 13385 12398 20850 83961 17999 100042150 16206 107568 20416 17246 211323 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 26413 26417 16331 110157 17096 12700 26395 12984 26396 20846 20848 22631 18712 18749 16452 20851 20293 18176 19247 20662 18708 15461 16150 14281 18706 12981 14784 14389 20850 12982 20416 15900 18413 16653 20963 18747 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 29857 16765 12443 320795 20648 65964 26415 26399 26397 13631 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 19294 69697 210126 17309 13636 211446 17920 13645 11828 13836 11830 216963 233765 65970 17356 20909 22323 13649 16582 11848 15234 17295 22793 19877 17973 109711 76884 22330 12387 20336 12550 50884 16001 11308 16000 18717 12385 13367 11845 17906 12388 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 16416 17164 26413 26417 19229 15170 11848 15239 19271 16410 15516 14159 22370 27371 14360 224105 11640 226101 19255 207565 12562 26416 12389 12402 11651 17973 15519 19247 103583 22330 14783 12387 14784 18750 14388 11840 18127 12385 19303 13430 26397 20779 22339 14083 14254 16542 110157 29875 18753 26395 26396 18803 109880 18607 17974 19877 640703 18751 18708 26399 18706 230126 19094 17999 18747 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 15361 328572 12028 12567 116870 13684 17869 17395 69719 20425 67154 12530 13681 11757 109115 216185 20713 108143 18712 66464 15510 14732 100088 100043349 208643 72504 12914 12151 56426 15519 21429 67025 59026 380669 12444 16828 13557 21752 67014 72195 64602 66942 22042 75597 18642 13806 15902 13665 67065 68632 17187 12035 18103 14534 18263 56456 18102 15525 17127 170676 17128 100683 27354 21877 22059 20525 56505 20174 20613 81601 11799 14283 18148 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 20779 18481 22034 19353 26404 216527 64143 19091 70686 26406 26398 14360 224105 17096 22612 15162 12143 26416 14191 18218 63953 18479 16818 26399 19252 19766 66513 19094 56044 26397 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 12703 26419 26417 15170 17342 17096 56484 12914 12402 17311 11651 19247 20662 15461 22324 12043 14783 13448 14784 19211 14388 20416 16590 26411 21682 20583 110157 16923 240752 14158 17444 114715 17179 114716 56792 26395 23921 26396 13857 12015 19277 20846 13856 20848 16452 18607 56637 18708 18706 20850 12929 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 20423 26419 19206 12159 18550 14178 14734 26420 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 20779 22339 19353 16412 14268 11490 22341 22329 11489 20229 16516 74145 21923 21817 11495 11501 212503 18126 14205 12981 104099 12982 19303 12927 20750 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 227525 319583 59047 21673 54125 72103 75570 66408 56626 108138 22596 14375 19090 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 271457 16476 26419 19353 26413 26417 11848 26398 16331 13685 15239 19271 13684 26401 224105 23871 56717 19255 73178 18479 12402 20404 11651 17973 19247 14064 20662 15461 56513 12387 14784 12928 14389 12550 14388 20416 12385 11845 19303 109905 20779 14083 19246 11789 18759 110157 15234 17295 26395 26396 12015 18803 13653 215449 18607 17974 56716 16332 11652 20613 18708 107746 18706 18762 18222 97998 16211 70584 224116 58194 226970 74030 12929 74370 13858 67605 74334 12927 56705 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 20779 14083 14677 19246 13645 26413 26417 15170 13649 14679 227753 73178 20846 18803 20848 17974 18176 18479 17973 19247 20662 18708 15461 74769 18706 14784 21894 14388 18717 20416 16653 218397 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 14702 14062 320129 14677 18797 67804 16801 56440 14688 18795 19878 75547 22323 109689 14687 11848 14673 14681 14678 18796 18753 14679 192662 14675 13429 14672 14674 14682 14676 22793 19877 320795 14064 18751 18708 18706 14061 18750 18127 17906 18752 13430 22068 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 14083 19353 16412 12767 14177 11848 21788 20971 20315 66911 18753 20304 17395 14268 17242 16774 57916 67903 21825 16772 11489 53378 21923 109711 18815 14061 14182 18750 14173 14369 16402 13430 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 26419 18519 328572 27374 12566 18002 216080 65019 23988 53892 225055 67956 13163 100043295 26416 26374 17248 219022 13560 110750 67773 226830 50883 69181 73251 333654 19052 12450 110854 12914 11651 67025 59026 11920 12578 15258 22059 93687 27401 214897 21849 252870 18753 70425 103236 27373 11350 104318 12649 56637 22632 26420 12428 68098 81601 17246 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 19225 18021 19246 16476 208650 14462 12567 19016 16364 21926 13653 13654 16191 57765 17254 19272 12477 13655 66889 12367 22778 640703 13139 17132 20371 18018 18019 14281 12981 16396 16184 16183 15978 13555 14103 21947 13656 381319 18986 14283 16477 16189 18761 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 12387 16480 12550 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 14676 16367 14677 16476 26419 19353 18479 26413 26417 14687 11848 14673 14681 14678 14281 14679 12562 14675 26416 14739 14672 14674 14682 13712 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 14702 20779 14083 14677 18797 19353 12912 14688 26413 18795 26417 14687 110157 14681 14678 18796 14679 26395 26396 18803 234779 11835 11651 18708 15461 14714 75273 14281 18706 20415 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 22059 12795 12532 12447 50883 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 18021 14284 16476 328572 23857 83995 17390 18792 14609 20683 17395 12443 16774 20293 16478 18018 18019 12428 17313 15368 16193 13179 353170 16878 21824 22282 18793 11911 12843 18127 14283 12578 16477 192897 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 17535 27354 13016 21849 54401 19367 225182 19356 11350 26374 12530 15270 12532 50883 21975 12144 227525 12122 108138 81601 211651 13006 11920 20184 70681 12189 17246 24061 93765 27223 240087 19360 21750 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 22029 21937 53859 11796 67384 26419 12675 670717 12905 11783 12366 18033 18035 13163 21926 12369 14082 12371 14102 12503 12122 12367 26408 19697 12043 26400 12370 19766 14103 12368 12633 71609 22030 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 20387 117149 20201 13003 17087 106759 12111 16179 108960 21899 21898 11848 142980 20210 12675 20202 24088 21897 266632 17874 12475 15510 16150 16151 434174 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 16451 14462 16173 16171 50931 20847 16162 16159 21803 20846 246779 21926 50498 20849 20848 16452 16176 57765 54721 16161 16160 16193 16183 15978 20850 16195 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 26419 19353 11820 11848 12675 670717 11783 192662 66593 11798 18749 11651 18815 13555 12368 20416 18049 11796 22059 22034 18205 78405 16179 18759 94275 17393 18211 18053 12125 17874 12064 12015 18550 17984 17136 68585 18412 20661 72843 22627 192656 12070 75625 18377 170936 19716 20598 66647 12371 11852 11853 235402 17392 12367 18708 16150 26420 11491 18706 18762 16151 11797 26414 19164 100042305 59287 208117 100039623 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 56637 14367 606496 214897 11789 16974 72293 12005 13542 18719 240756 22416 13544 13543 71810 26554 12387 84095 226849 12389 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 20779 16476 26413 12393 26417 24064 19229 15529 18792 17395 14170 12558 20846 18803 64654 12322 14186 18607 14184 20851 12402 11651 19247 20662 18708 14281 18706 20111 14784 14182 231637 14164 70584 83379 12550 13043 171463 17967 18793 14183 14388 20416 327826 12388 20750 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 17128 21909 17129 11705 55994 11477 110542 12162 14225 12168 17125 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 84704 114774 215114 18813 57257 225115 15382 50523 57908 75502 56406 104263 19229 627557 12445 14228 22200 22215 18095 21413 232286 18477 56218 227753 328365 17152 72993 17978 21815 268903 11835 11651 12571 20807 75273 12387 22596 14375 12189 59004 12578 19090 229615 12443 59035 99982 50528 12370 56469 22196 19014 227292 110651 56705 14200 21804 76804 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 18720 22793 20779 19353 11651 11652 13649 22323 11848 18708 18706 12387 14360 16480 12550 16475 12374 18803 12385 12388 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 16476 16451 12608 19353 12048 26398 21857 17869 17342 18753 229615 12609 15162 20846 16803 26416 17210 22027 20848 99571 56458 19267 21943 12702 232345 12944 16452 16362 11651 54721 19247 20662 18708 22324 14281 26399 18706 14784 16193 14389 19094 56469 14388 16477 16911 16195 16194 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 13837 13836 13842 13840 13841 13839 13640 13838 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 27354 235559 18817 19361 12566 54401 269582 19367 19718 19356 69263 15574 12530 12190 235610 12649 12532 22631 19355 12234 17220 72930 214552 19052 17216 51792 23834 66131 54380 21853 68275 106344 103583 72151 19891 12428 211651 17246 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 12234 56637 93687 14367 606496 11789 26965 16974 21402 12005 13542 22416 13544 13543 12387 27373 104318 12006 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 16367 14083 19246 110157 18753 12015 14694 22627 22631 18607 17974 11651 18760 19247 20662 18708 15461 14783 18706 14784 18762 12928 16001 16000 384783 20416 12929 19303 12927 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 16176 26413 26417 640703 71914 26398 195046 69538 26399 26400 16173 12362 26395 26396 21926 18667 22329 26397 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 19682 245650 243923 77974 14688 14697 107477 14913 212541 24013 20215 19892 225600 19739 18587 79235 14699 214111 14685 14919 12788 18588 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 193740 18021 14451 27401 328572 18817 12442 12567 12566 17869 17390 20683 26395 12443 12190 12531 50883 606496 19645 12914 104156 12534 14281 12428 13982 11799 18005 54124 108000 12615 14235 12616 12578 22594 16775 20877 12447 21802 15379 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 14702 110355 227288 271457 18797 14688 18795 109689 14678 18796 17096 15162 14675 13429 30955 104709 14191 14676 18805 18607 18754 12402 216869 11651 18751 18750 18752 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 16456 21810 78369 16411 15896 14131 100689 110135 16414 14161 14723 12266 14058 19123 18792 385643 99571 22329 21838 15894 381924 83964 16007 16408 18791 16409 18793 21947 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 20528 19047 20909 16334 18759 106628 240028 50518 55948 22318 54401 104215 14936 16337 140491 100039786 22628 22627 22631 22629 210789 56637 11651 11652 640703 18762 20913 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 271457 16476 18783 17869 14360 22612 23988 73178 30955 104709 20851 12402 13860 16818 232906 16971 18591 13430 18596 17356 94212 110157 29875 26395 26396 11350 20846 215449 20848 20698 13609 16452 17974 18708 76884 107746 74769 18706 26400 242687 20850 13043 50884 26414 11308 110651 12927 19106 16706 26419 19353 16416 26413 26417 68089 67771 11848 26398 11867 56378 19271 16410 66713 74117 17096 19255 192662 15162 108100 12143 101314 76709 14191 72930 19052 51792 18479 17973 19247 20662 15461 20807 14783 13448 14784 12928 18750 19211 14388 20416 109905 218397 20779 19246 12988 55948 54401 18753 20491 65962 21345 20469 26941 18803 69710 98910 19341 214384 100039786 238130 22628 60595 22627 109880 22631 13712 22629 18754 18176 16478 14281 26420 16653 22325 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 11477 14225 11482 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 19294 20779 16456 14083 227377 19353 16416 18596 17356 29875 16410 215449 12737 58998 58235 19274 18708 107746 18706 12387 21894 12928 12550 18717 12385 109905 18591 22325 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 16476 26419 19353 26413 26417 15170 16331 12675 26401 23871 17096 26416 100039026 11651 20662 15461 13448 14784 19211 26409 20416 218397 12988 22034 14130 94212 26411 110157 19055 26395 18033 18035 13712 18607 17060 234779 24056 12047 19057 240354 12229 108837 108723 19264 26377 18036 12517 640703 12518 18708 16150 12478 19697 18018 15985 12483 14281 12325 18987 19056 18706 12042 16151 22325 20963 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 102098 207212 57257 109904 53972 16801 213498 110596 75547 11857 11848 11855 192662 69710 223435 13605 12576 106952 216445 109934 16800 110279 23853 22324 17925 72754 69632 171207 232906 11856 213522 14570 442801 117600 71704 94190 50768 52666 234094 22325 56349 73167 17207 223254 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 22249 20910 20614 20979 20907 11435 22318 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 328572 18129 18131 14462 18132 13388 13728 50530 56309 17869 16449 225164 11487 14357 17150 13389 18011 227325 16450 13386 12805 16924 54485 53870 12234 12575 12402 26965 21402 433759 13806 53869 20185 27401 19208 13016 225182 12443 18550 13429 103806 20602 56381 11489 18128 22632 99982 19664 270118 18222 16396 50754 100042305 13858 59287 208117 16189 100039623 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 17242 71951 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 16186 16451 16453 12048 13709 16992 12445 17869 20683 20851 18646 19247 16185 12571 20662 18708 20371 12043 12444 16818 12428 18706 14784 16184 16183 14389 20850 14103 20416 16189 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 20779 16476 26419 19353 26413 11435 26417 110157 56717 26395 26396 12015 20848 84092 18016 67588 16452 13867 11448 73181 67299 18176 11651 19247 20662 18708 15461 74769 14281 19056 26420 18706 14784 13866 26414 100042150 20416 16653 211323 18747 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 14702 271457 18797 14688 18795 22323 109689 14678 18796 17096 15162 14675 140580 13429 30955 104709 14191 14676 18607 18806 19052 51792 19354 12402 12765 216869 19349 94176 11651 18751 18750 53869 18752 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 15376 15375 15377 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 20969 20970 15529 20971 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 22339 16456 21810 20969 16416 110135 18596 14161 94216 226519 12830 16542 20971 16410 22370 16777 18792 21813 12829 14268 12828 12826 21825 99571 12842 20698 21838 21923 15891 14118 16728 18613 13612 16423 16007 434174 18793 16399 12843 18591 16775 20750 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 14061 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 12703 16186 16476 16451 26419 16453 17164 26413 26417 19229 11848 12566 17869 14360 13449 26416 20851 19247 16185 20662 15461 12043 16818 56324 14784 22780 20844 14389 216233 384783 20416 218397 16367 110157 12700 26395 26396 20846 20848 12702 18754 18176 18751 18708 14281 26420 18706 16184 16183 15978 19094 20850 16653 20963 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 14733 14734 71951 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 21853 20893 27373 53610 11865 12953 12952 12753 140858 18626 12649 18627 217166 18143 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 12703 16186 56717 26416 19349 11909 20852 16185 16818 14939 12010 26397 20303 12525 14938 12526 16177 17873 18034 13813 15284 23882 12774 19698 15007 16173 18033 16162 16159 20846 20849 20848 192656 16452 16182 14969 14968 16176 57765 12500 12502 18126 16174 12503 12501 54721 19697 16161 16160 14281 26399 16184 12504 16183 15978 20850 14103 56632 16189 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 16420 16421 20969 21812 17123 14118 16410 13612 22370 18792 16007 14268 18793 320910 16401 16419 22329 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 16202 57257 19353 16416 26413 26417 19229 11848 16410 22370 21813 12402 11651 15519 19247 22330 13612 21894 16001 14173 16000 12843 19303 16367 12977 20779 22339 16456 14083 12978 20969 12833 12832 12815 30924 12814 18704 12831 78560 94216 17304 12830 16542 224020 107650 12829 14268 12828 12826 12825 12824 12842 12576 12836 12835 19877 12834 18708 18706 12370 12927 20750 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 22059 18519 328572 12028 22151 60525 64384 22143 17261 50709 93759 15395 68738 64383 56484 56458 209011 12575 19017 12914 17927 208727 14375 14200 54601 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 218772 19411 19401 26419 18519 328572 26413 26417 17977 19659 17978 17420 26416 12572 66671 20602 15183 268903 20181 20183 17979 12914 20182 11651 22337 12534 433759 18750 18752 18747 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 26754 11863 22059 15519 67923 112407 112406 22346 15251 71745 12578 53417 319594 56292 14694 216440 56438 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 20387 20423 16476 12608 328572 16334 22433 18095 11764 22370 11957 20683 78330 13508 20703 12576 12822 11819 320951 667310 14526 20390 22287 268903 18029 11835 72082 17979 12914 18027 15376 114604 15375 100041004 15377 14281 238055 13982 18986 12189 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 26419 93687 19353 11848 18099 22612 19016 12322 68652 19877 14367 26564 216869 208846 192176 84505 13542 320790 13544 18019 13543 26420 22418 18762 68588 66513 26414 14368 26409 14369 57265 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 14702 20779 14677 18797 14688 18795 19878 14687 11848 14681 14678 17390 18796 14679 17395 14675 14672 14674 14682 14676 18176 13983 11651 20662 18708 15461 268980 14680 15200 75273 18706 13982 14784 19094 16001 16000 20416 18127 17698 16653 12927 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 21415 67772 16543 14175 16476 73389 67087 99377 72693 81004 328572 18014 64406 73739 80334 12592 59024 12291 17869 17390 17342 21413 17395 17978 12006 12234 11835 13380 26965 21402 12444 21752 12387 15182 433759 16007 12550 15902 12578 16842 21416 100683 13003 11789 13016 20583 55948 54401 12443 12326 100039786 22628 22627 22631 22629 20174 21885 13544 17709 21414 20997 140486 21886 20586 234130 21372 11513 103573 665113 16600 21888 17877 14797 16678 17928 77578 18741 16319 12590 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 26419 12048 15170 21682 16331 16923 17096 18033 13857 20846 18803 26416 13856 12702 16452 234779 20851 12402 12229 19247 20662 18708 15461 12043 107746 14784 20850 14388 384783 20416 12929 109905 22325 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 17873 22034 19353 23882 216527 26406 269881 53608 26401 22166 330177 216965 26407 26416 68652 26408 640703 12323 26399 66513 19094 13197 11920 26409 22030 26397 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 100683 73389 27401 22642 17869 224105 23988 18854 109115 216185 108143 66464 56505 56637 20174 19052 12005 81601 72195 50754 226849 12578 17187 14534 56456 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 19225 22339 14677 19353 26413 18596 26417 14687 11848 16542 14681 14678 18796 14679 17250 18803 18591 20698 13609 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 17126 20779 22339 14254 11820 14360 17096 22612 20563 21813 15162 11905 19122 12143 620395 21803 16772 14191 21809 21812 16818 14182 14733 14173 211323 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 16476 18797 26419 19353 18783 26413 18795 26417 19229 11848 18796 18755 26416 70086 224129 11512 11514 11515 13617 13616 13615 104110 13618 58861 432530 210044 105243 104111 11651 15461 20544 12928 18750 12843 18761 20779 14677 13614 14687 14673 83995 110157 14681 14678 18753 14679 26395 26396 14675 12825 14672 14682 14676 16452 18754 18751 14680 14281 11513 12927 18752 22068 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 22339 14205 18654 18187 14254 18186 14257 22340 22341 16542 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 16476 26419 19353 18759 26398 14360 73178 12015 18803 17974 216869 11651 17973 14064 21872 18708 12488 170643 74769 54631 26420 56513 170484 18706 14784 18762 26414 22068 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 14702 16476 18797 19353 16801 14688 19229 11848 17390 17395 17096 224129 11512 14674 11514 11515 104110 18806 432530 210044 104111 11651 18760 15461 65086 14745 78134 53978 12928 11548 14388 19303 20779 14083 14677 22051 13649 14687 14673 14681 14678 18753 14679 65962 18033 14675 18035 18803 14672 14682 14676 56637 18754 12367 18708 19697 15200 74769 14281 21844 11513 12927 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 16398 241226 213119 16412 226519 16410 22370 18792 12475 67374 17242 12520 21825 21826 99571 22329 140559 12822 14118 114249 121021 18793 18073 12843 16775 22339 21810 12833 12832 110135 14161 12815 12814 12831 94216 12830 16780 16782 16773 16777 16779 12829 14268 12828 12826 16774 12825 12824 16772 12842 16776 74145 12836 21923 12835 21817 12834 16400 104099 16401 16403 16402 16404 319480 20750 109700 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 14289 20779 14293 76701 19353 16416 16412 110135 18596 16414 14161 50701 13649 16410 22370 15234 330662 18792 17395 14268 21803 99571 16419 16400 17392 18815 12928 16409 18793 16971 56640 14756 13035 16402 22359 17381 12927 17386 71785 18787 14294 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 12912 16412 328572 17869 20683 19650 56484 20375 12579 12575 15183 110854 13380 12043 22418 433759 15902 12843 12189 17187 17126 17127 17128 14581 21374 94280 15360 12192 22642 18596 18044 18045 18046 12759 13435 22084 18173 66271 14319 23894 20304 12609 29811 12606 17988 229663 21873 20377 12443 56752 17122 56363 12576 21673 16852 13866 13198 13197 12633 16403 15900 192897 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 13867 13645 15519 13874 13649 18183 15200 13869 13866 12223 83961 100042150 11839 211323 21802 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 14702 110355 14688 14461 56233 15185 15184 22151 54401 14815 22143 12053 232232 12326 17260 20602 68558 170787 19727 71458 22627 79221 15183 15519 20807 14460 13982 103573 208727 22196 19384 19386 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 229317 22601 17131 75788 18854 21813 13163 21803 12389 11798 19045 68652 19052 216869 21809 21812 20662 56513 12387 14784 14219 66513 26409 20416 17126 17127 17128 83814 12322 22627 66313 21814 17872 18607 73122 240025 20742 68010 71978 218441 67068 93836 19053 20901 12005 230597 13132 16396 107568 14225 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 16421 16407 12550 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 16822 16476 26419 18751 26398 26411 16797 13169 26401 17444 12928 26409 12929 26410 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 18021 54720 26419 12048 328572 12028 26417 26401 18755 26416 100039026 18712 12914 12043 18750 18761 93687 55948 54401 18753 17261 12015 12326 100039786 22628 26410 22627 22631 22629 56637 18754 12367 640703 18751 56398 18018 18019 100039592 26420 227720 104248 14232 18762 16211 53901 103573 19384 238276 14225 18752 18747 15370 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 53859 15170 16331 12675 14360 12402 11651 17973 19247 20662 15461 22324 16818 14784 14389 18750 19211 20416 109905 18761 64177 16822 12988 22034 16428 94212 26411 16797 17444 18803 26410 18607 14969 14968 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 192176 18751 12487 16150 19395 12519 13169 12524 12042 54354 16151 22376 12504 109305 24055 53416 20866 23880 19419 77799 16653 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 22339 26413 14254 26417 216148 18803 15251 12389 18607 12402 18654 18187 11651 17973 15519 18186 19247 640703 18751 22340 18708 12488 18706 18750 18127 18747 218397 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 14784 56717 13645 13614 20416 13649 20662 15461 13617 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 14702 14634 67661 14677 20423 19335 100041953 93687 214897 14633 14688 19206 19646 20466 14687 14681 14678 18753 14679 70425 26395 103236 27373 245688 104318 12234 56637 60406 12914 216869 16854 15376 11651 20467 103583 15182 433759 56469 103573 211401 269209 24069 20747 16568 21821 18747 319757 14632 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 16367 105504 19246 211446 20411 16334 20393 18759 106628 16331 13685 104215 16337 23921 56484 12389 19262 18607 17974 12402 11651 17973 11652 19247 14064 53413 20662 18708 15461 107746 14783 56513 18706 13448 14784 18762 20336 12928 69940 50915 107371 20416 66482 218397 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 18590 54635 18595 18596 18591 71785 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 20779 14083 13636 57257 16332 19353 13836 11431 12402 18479 11848 18708 18706 14784 21844 232906 20416 22325 12927 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 100040260 23980 271457 16476 12048 12912 19060 11843 23938 56419 17907 23939 26405 19730 22695 67603 56613 73086 56717 73178 17260 11909 11651 667739 13860 56044 13645 13649 110157 29875 26395 26396 20846 20848 78757 56716 227743 18708 76884 74769 18706 242687 50884 11308 110651 16706 26419 19353 26413 26417 68089 67771 26398 11867 56378 66713 74117 26401 27371 108100 101314 76709 17125 18805 18806 19052 51792 14064 20662 15461 20807 20544 14784 18750 14388 20779 12334 55948 54401 18753 12015 98910 13653 100039786 22628 22627 109880 22631 13712 22629 18607 71978 18176 640703 14281 26420 225870 18762 19252 16653 22325 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 19353 21770 11848 100040603 29875 18472 13424 56430 23924 12570 18476 11350 13131 17755 13193 83431 18475 19699 12569 27226 100039026 22627 640703 18221 12568 16976 22359 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 19352 19245 20779 19877 12575 19353 16412 26413 11853 26417 11848 12566 12428 11606 22143 13653 19244 12927 12447 56187 107503 109700 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 20779 26419 19353 16416 26398 14360 17096 22612 15162 13844 270190 12143 13429 13642 13641 14191 50780 17974 13846 18708 16818 18706 21844 16399 26409 19249 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 16398 12912 16412 26413 26417 26398 14268 26416 12842 22341 14205 11651 14257 20662 18708 18706 20111 14784 12928 19094 12843 20416 16401 16402 109700 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 20779 13636 13645 13836 16416 216963 109689 13649 15234 17295 14675 14672 14682 19159 19158 14676 78618 16554 320495 16867 216869 216859 50753 212285 231821 17973 70676 232227 11555 16399 22095 11845 19303 11607 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 16451 22061 22601 328572 12028 12795 18817 12566 17869 16190 20683 23988 93759 12366 18854 16450 26416 56484 12235 18749 11486 12575 12571 22062 12237 319618 12534 30948 16180 226646 229933 21945 15499 22431 22142 14252 11576 18196 12018 207742 23886 19012 63958 68048 18611 12448 268882 18787 14651 223752 56612 19361 18211 55948 83814 12125 11350 12190 12649 14694 20703 15214 19645 14102 80707 19697 14460 12428 68098 81601 16396 19094 17246 14104 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 14702 20779 20292 14677 56066 56744 12766 55985 14688 26413 15945 26417 109689 14687 110157 14681 14678 14679 56717 26395 26396 26416 13429 18607 78757 56716 18176 227743 11651 17329 18708 15461 74769 26399 18706 19094 16653 26397 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 12608 12048 16188 27058 194231 16331 12700 12984 22628 22631 18712 18749 16452 15901 20851 19247 18708 18706 14784 433759 14389 20850 20416 18413 18747 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 110355 14702 320129 19353 16801 14688 11848 14360 18796 22612 17096 15162 12143 18755 26416 14674 30955 22329 14191 104709 216869 11651 14697 170735 15894 16818 18750 53869 18127 18761 20779 13645 19091 13649 19222 21390 14673 19214 14678 18753 14675 26941 13429 14672 14682 14676 21817 19877 18754 20339 18751 18762 19094 20963 18752 18747 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 13645 19353 16412 13649 226519 15235 16780 18858 16782 55948 12821 16773 54401 12527 16777 16779 17295 16774 12369 16772 100039786 22628 16776 22627 22631 22629 13867 20181 20183 20182 11651 18708 15461 18706 16175 14784 19882 13866 12550 18750 20416 16403 16775 192897 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 26413 26417 13685 12566 670717 13684 56430 56717 18854 13681 12234 18805 18806 11651 103583 15461 18750 12447 16367 20393 22084 110157 55948 54401 12421 64930 75705 26395 13629 26396 22241 54170 18569 109270 73826 52187 29869 100039786 68441 22628 51897 22627 109880 74747 22631 100042570 22629 106298 18607 245670 78757 56716 22632 19017 18176 227743 16150 20111 97998 20787 74370 67605 16653 13631 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 12234 53859 18034 18033 19698 12675 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 16476 12048 13836 64058 328572 57913 11783 20683 12362 12053 26374 110750 12450 12575 12914 13380 15375 22062 22337 12043 21781 15182 13555 16878 12368 11576 12018 23886 14534 18787 13003 13649 11910 74747 26921 20312 19079 21933 242705 19645 71887 15469 14102 107986 12177 12122 27056 29813 14149 66824 57748 21981 68428 13207 20586 14000 71361 235281 268973 14775 13496 382985 15194 67941 17246 12607 209456 218215 22178 20750 17685 66813 59092 17350 60599 12050 22061 319801 140742 12028 12227 12795 18996 12142 18997 18861 15248 20400 13033 66214 94223 69076 17390 12454 21354 18854 17210 12389 108143 12822 13615 12521 13557 19211 21802 193740 18538 100683 22059 18044 11789 18045 18046 20583 22084 55948 15234 17988 17295 20724 59035 12047 68098 19252 240672 12062 13197 16009 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 104110 18754 432530 210044 104111 12912 14680 78134 73086 11513 224129 11512 11514 11515 18747 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 18102 20779 271457 19246 13645 19353 56440 15170 13649 15239 14673 29875 17393 18212 19876 11487 14360 16002 12064 12558 104836 17295 109620 17288 11350 63955 20562 56805 14674 12914 19349 17392 12367 15461 14573 12387 21844 16480 12550 19713 16001 74030 12385 11845 12388 14585 13430 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 22059 216963 21770 20878 72119 18035 16475 83431 218977 100121 12531 66077 18245 12877 56371 56637 75786 21335 18479 11651 11799 13197 19384 12615 54126 12189 17246 320165 20877 18747 218397 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 22029 53859 11796 16476 26419 16453 22034 12048 208650 26398 17869 26401 18033 18035 26416 30955 104709 22031 64435 56196 21939 21929 11651 18708 19697 74769 26420 18706 19094 20850 11797 26414 21947 22030 16189 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 71990 236193 20587 17979 13983 12266 57376 22200 18002 20586 17977 23957 17978 22192 11614 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 20878 20877 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 17128 22059 12912 13728 13033 22084 55948 17869 54401 64930 56717 12539 100039786 22628 22627 22631 22629 56637 56716 12283 75770 20869 19165 15519 70661 232944 22350 71728 381979 70415 66993 17691 13982 72149 235344 74343 18612 227154 74370 67605 18747 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 13846 13845 13844 270190 13642 13641 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 18205 12912 17164 26413 23938 26417 23939 26405 110157 18753 73086 193034 26395 19762 19769 26416 98878 13653 215449 17260 12569 109880 13712 18176 15461 20807 14281 26399 20111 12568 109905 16653 26397 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 22029 21937 11796 67384 228355 18201 26406 18759 12675 26401 22166 18033 20846 21926 12389 18412 14694 68652 26921 21929 14082 20598 26408 20597 16150 19697 11491 26400 18762 12370 16151 19766 66513 11797 26412 665113 27206 74256 26409 399510 225028 67338 71609 21938 22030 26397 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 11364 22228 22139 11370 18609 12894 12608 15107 12912 71911 234724 230163 18534 16334 20526 20927 16514 21869 14377 16006 15227 14815 12609 21405 20683 12606 11655 103988 11657 78070 13386 15378 15376 11651 15375 18015 15377 14061 22042 11576 11806 100040592 12895 18770 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 16476 26419 19353 26413 26417 68089 56419 67771 26398 26403 11867 56378 66713 74117 26401 224105 22612 56717 73178 192662 108100 26416 76709 404710 18805 18479 12402 11909 14064 53413 13860 15461 56513 12387 12631 12550 12385 54126 17906 16885 16886 26397 20779 73341 11789 110157 29875 15208 51789 18000 226751 18508 109880 56637 18754 18708 26420 26399 13383 18706 26400 18762 21844 70584 19417 22325 12927 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 110355 14702 18797 19353 14688 18795 19229 15170 11848 16331 15239 20315 14360 18796 17395 22612 17096 56717 15162 12143 56458 14674 30955 14191 104709 20851 18479 216869 11651 19247 170735 22324 16818 12928 12631 19303 16885 20779 14083 14677 12988 64143 12767 94212 14687 14681 14678 14679 20847 12015 20846 13429 215449 20848 26385 20479 14694 50778 116733 56085 16452 18607 14969 78757 14968 56716 12500 12502 11852 11853 12503 227743 19264 12501 18708 74769 18706 18762 16396 231637 12504 20850 12927 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 16985 102626 14009 17164 12912 15507 20807 110157 22084 55948 21823 54401 19094 21423 26416 12531 100039786 22628 22627 22631 22629 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 16476 93687 26413 21770 11789 26417 13016 13388 18099 17869 11487 21405 14357 22408 12443 100039026 12234 18128 56637 73016 56811 93960 14296 21885 12914 13380 16974 14362 13542 12005 103583 19664 14281 12387 433759 66513 19164 17999 24117 26409 100042305 19015 14797 59287 208117 100039623 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 20423 73389 22061 64058 328572 12028 18817 17304 12675 16449 18753 20683 18854 11350 63955 100039786 13654 12234 20724 11486 12575 16400 192119 22032 14102 20833 18294 21420 73472 20148 16150 14149 14027 22337 18104 66993 229933 16396 14776 14252 13197 107568 23886 17246 16009 12578 68048 192897 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 12703 16451 15979 12608 328572 26413 17131 26417 26403 69635 26401 18753 12362 19255 56717 26395 108058 20846 215449 12322 20848 16452 16176 12402 12914 16362 11651 19247 640703 18708 107746 12323 96979 12325 16391 18706 15978 56469 12929 59004 109905 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 18720 18806 19353 12847 13196 12757 56041 107338 228998 12504 76932 11771 11773 56494 68137 74325 11840 260302 19158 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 73914 16177 16476 26419 22034 16179 26406 18759 12675 266632 12362 17874 18033 18412 68652 16176 18708 16150 19697 16180 26399 18706 16175 18762 16151 66513 26409 16181 54473 93765 111173 16178 66589 225471 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 22088 74551 18514 16476 12640 26419 110308 14229 68094 12912 19060 83797 328572 26413 12028 12355 22354 26417 225888 14462 100043429 18736 14228 16667 14815 17977 17978 26416 20375 99571 12569 18749 16191 12575 20851 12914 11651 15519 15894 15182 433759 11576 12991 21374 22059 20393 83995 19109 55948 18033 20846 13653 20588 22629 56637 57765 16362 20339 16163 19697 18018 14281 26420 12981 16193 20586 16183 15978 19094 20850 18976 26414 16664 12568 18986 17246 16189 18747 15370 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 22088 20779 271457 14083 13645 208650 24064 13649 15239 110157 100041766 218038 13854 216080 70527 231125 66700 104015 13429 84092 16443 18176 12402 20404 20662 18708 15461 74769 18706 14784 66105 58194 16206 20416 54126 13858 16653 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 73389 18519 328572 27374 15248 12445 12566 17869 18792 11783 20683 93759 17215 18968 104158 19650 234677 20859 12369 12530 17865 17210 22294 83767 20135 20133 22171 12580 13909 19385 56353 67935 52679 50496 12575 23834 436059 13361 12914 67155 211586 18392 22062 12534 21781 13557 433759 13559 13555 104394 11920 12189 12578 22594 12447 12448 14534 18787 100683 21877 235559 209446 19646 19651 21849 12606 225182 12576 22632 242705 19645 12428 12419 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 21937 12234 21929 240354 22034 257632 16150 19697 12675 12042 66105 16151 18033 18750 11797 18035 103573 74256 21926 11920 19384 111173 192656 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 14360 13839 13640 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 53859 15170 12675 14360 12402 11651 20662 15461 22324 16818 14784 18750 20416 109905 12010 18761 12525 64177 12526 16822 12988 22034 94212 16797 17444 15007 18803 26410 18607 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 18646 18751 12487 16150 19395 12519 12524 12042 54354 16151 109305 20866 19419 16653 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 16476 20687 26413 20466 26417 22215 17869 20683 56717 245688 21803 229512 60406 17119 11651 15519 22427 208084 20467 28113 245474 101185 21749 497652 13982 21752 103677 21951 15182 22596 22431 15381 433759 98999 13555 11546 57321 72400 100043508 11920 14375 17187 19360 21750 17535 17127 15976 100041953 27354 13645 19646 13649 19367 18033 11350 12443 15574 22627 12576 19355 11819 12144 16362 14281 16183 15978 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 16476 328572 12567 12445 12566 17342 93759 19016 26416 17260 20375 14836 19052 20587 12575 15183 12914 11909 17927 12418 21429 12571 12444 21781 13557 433759 13555 104394 270627 18505 14312 12578 19660 20937 12447 13433 12715 56321 223922 21374 12608 27401 19646 13709 12393 13016 110157 12609 12606 17295 11350 12443 12576 21808 20390 242705 19645 26420 12428 12981 20586 19094 17246 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 17126 73122 17127 218210 17128 19042 69274 26413 26417 640703 100039592 227720 26401 16211 22196 227292 59004 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 16476 12912 328572 16414 14461 56233 20315 20683 23871 17977 17978 17210 15378 21786 13805 12914 11651 16828 21752 15368 22042 13806 15902 18787 26754 17127 22339 17128 15277 13614 15275 79362 11520 12767 14151 230099 18671 16846 18655 19883 112407 11535 12870 20525 16006 23959 26357 72157 18746 18641 103988 17988 11674 170768 20893 17684 22041 18550 13856 15251 100042570 11863 18126 14281 18148 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 26419 16412 26403 18472 14360 14811 13131 19099 17755 19699 12569 56637 17974 16800 16400 12402 11651 18708 107746 14812 18706 26400 12568 16976 12929 22359 109905 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 21933 14082 26419 26413 26417 26398 18708 20597 16150 12675 74769 18706 26401 12370 16151 19766 65111 12633 22035 71609 22030 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 14702 19094 26419 14688 26416 12918 14680 26420 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 12977 20779 22339 19246 16451 12978 16453 13645 229317 16412 18596 13649 16334 16542 15234 16337 19255 17295 20846 70361 19341 20848 20851 12914 20852 20662 18708 74769 100039592 18706 14784 16211 20850 56469 14388 20416 18591 19106 109700 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 17128 19042 69274 26413 17131 75788 17129 12159 55994 66042 17130 11798 18121 12168 66313 11625 12156 17125 68652 17872 69585 19045 12161 56637 12166 12667 68010 68799 12622 218441 244058 23892 14313 20481 227720 66513 26409 12162 227292 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 14676 14702 19877 14688 19878 14065 14064 11848 14061 18796 14675 14672 14674 17906 14682 FSH%NETPATH%FSH FSH 26396 12640 11652 14308 14309 72993 14772 26385 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog 22627 19207 117606 70208 59024 69792 264064 100041953 12387 110355 13548 14451 269209 14632 14633 16147 216869 13363 24069 19014 75050 18747 19206 15245 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor 433759 15507 11651 14083 11835 18708 12912 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor 19085 13163 19087 75901 75788 76630 19303 72183 12443 15529 18744 57258 17222 20481 56440 54601 67804 20682 20692 16478 20742 12189 21417 21781 211586 17977 21803 21808 21809 21813 21814 216080 100041766 66105 22196 22337 103573 76793 17869 227720 75465 67068 12399 54709 52563 69150 69957 12234 12442 230597 12505 24136 12530 22062 218210 13982 216869 433759 11651 14083 11835 18708 26411 12393 56484 14281 14282 16476 16477 20683 18607 20869 19645 22059 11909 12928 21402 12927 26965 12389 66513 18519 56438 26397 26399 56637 218441 23871 11910 19651 18706 13132 71770 68015 12567 12571 12575 12447 68999 22601 13018 26754 71728 12385 12386 17691 56458 268288 386655 104394 13805 18709 14030 14225 269338 14272 17872 97064 272359 99152 52206 15378 15405 15481 69260 16211 17128 17130 17258 17260 26413 12705 26417 18044 18045 18046 18102 56513 56371 59008 56317 94093 228026 18854 19042 71978 TCR%NETPATH%TCR TCR 107321 12519 12524 26558 73341 26431 12534 140580 14389 22388 27277 26396 12387 13548 11651 14083 18708 12912 11909 12928 56637 18709 26413 26417 19303 11486 16923 27387 19419 19395 56324 57257 98221 12608 20218 12469 71520 100039786 12675 30925 329693 83490 67300 26410 12914 12929 26416 12477 74039 13139 13205 13367 13430 94176 13448 12934 72349 269378 13653 13807 22154 13837 107508 19229 14158 286940 20430 320150 104248 12488 11350 23880 14381 101540 19260 14569 16797 54390 52013 53416 14784 107746 13169 232906 54167 12306 11744 432467 15516 81489 16150 16331 16428 16438 16453 12521 16818 16822 16828 16832 11857 240028 17085 17096 17829 17973 104112 18003 11928 18018 18019 232975 18033 18035 18036 18295 18479 20403 23853 77647 14026 56233 18613 227707 11431 18648 72157 240752 224020 18746 18803 234779 234374 233315 240754 74195 77853 170643 19056 18753 94212 56444 18760 59079 23939 26419 19094 26395 93742 140721 70737 15170 19247 19248 19262 19264 545902 11459 110157 19384 109905 218397 19697 71911 53378 24055 230126 20416 20491 20637 20662 20663 20779 20846 58231 20963 21682 22042 22088 22145 22165 50493 22323 22324 22325 22376 215280 22631 22637 108705 217069 22142 640703 72482 108723 72828 227937 78473 12402 208650 11502 192656 12523 54126 19134 12042 54353 68481 171543 13449 27371 19200 22248 12481 15239 13549 12500 12501 12502 16800 12504 12507 12516 12487 17444 LEPTIN%NETPATH%LEPTIN Leptin 20218 56637 12675 20416 105787 20779 20846 108079 18754 20112 20528 13649 18035 16370 13685 14360 606496 13684 667739 16367 16451 13866 17977 12568 12632 12944 20399 14682 192157 100705 18803 16001 234779 16419 16846 16885 18127 54611 11651 14083 12393 14784 26413 26419 13982 16150 16453 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor 13685 14360 667739 12566 11651 12984 14159 18708 15461 18750 15162 328572 16452 18751 26419 12703 16476 14786 20111 14191 58194 16590 16197 19247 22612 11909 56717 12928 17342 19273 67296 114715 110157 114716 13857 14936 218397 56150 19697 17179 17311 71520 56637 17698 19684 20850 29857 20851 18706 22350 67300 20662 21933 54607 20779 56468 12929 20846 26416 21682 22376 215280 11350 208650 26413 16331 16453 BCR%NETPATH%BCR BCR 13685 14360 606496 667739 12566 15162 18751 20111 12675 12572 12929 23921 26416 240354 208154 13712 14130 18717 240168 56792 19253 13448 14886 17060 15163 15387 16439 18021 77590 30955 18718 670717 242248 18761 12028 101476 83436 12053 20303 20848 12229 56743 117150 21432 18720 18719 108083 12369 14784 77799 107746 12371 17164 12483 12517 12518 15985 16150 16428 16438 16818 17096 17973 18003 18019 12387 18803 11651 14083 18753 12912 26411 18760 56484 14281 14282 16476 16477 18607 19645 15170 11909 12928 12927 218397 19697 56637 24055 20416 20662 20663 20846 21682 22324 22637 18709 108723 12042 26413 TNFALPHA%NETPATH%TNFALPHA TNFalpha 13649 16367 18750 328572 20850 14886 12028 12369 17164 21353 15185 72416 71833 56399 56338 544963 333654 18789 56532 14084 12539 67338 67067 100039026 446099 17846 11652 13057 56710 109658 14113 19698 211651 76589 19414 14229 69807 192176 103583 16650 11647 20019 56407 56312 29864 12091 20340 15182 71966 69721 56480 22627 11797 11796 11798 16535 100039592 16648 433759 16709 15507 17218 11651 17220 14083 26408 26403 12912 76784 50754 17931 18037 20018 18567 18616 16476 18637 16477 245841 100043714 54391 58994 19645 320795 23938 66593 21402 19173 19179 26965 19181 19182 12389 70247 66513 21762 22123 17463 66997 26399 23997 228775 19708 12051 77045 67891 432502 27207 12122 68015 57751 80859 64424 20586 20587 20588 68094 57376 21926 21938 22026 22166 22628 56458 22642 22682 231130 236733 12366 20017 224619 18201 16151 26572 56456 12905 14082 21934 12633 52440 12455 70834 233406 53376 211550 50797 21941 226525 26413 67384 20016 26417 22032 56489 73174 66413 23881 227648 216150 26406 666899 16396 228026 26405 18854 68652 66724 67857 26420 73086 19696 22034 230233 15519 14694 14388 12048 20181 54401 107951 13867 13728 22629 12367 22033 100041766 66105 22196 12234 100039786 26410 12914 26416 13205 13448 14784 15516 18033 18035 18479 26419 19247 20662 20663 20779 20846 22631 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 14388 54401 22629 13649 12367 13685 12015 14360 19353 18479 23844 12821 13684 109620 13844 16367 55948 13866 16403 192897 16418 11848 16773 16774 16776 22627 16777 16779 16780 226519 16782 16785 17126 11651 17127 14083 17295 11835 19882 18708 18753 18810 18750 20166 22352 213435 59079 18208 14281 12476 74769 16476 18707 18710 384783 22062 19247 22612 56717 100039786 20416 18706 20779 26416 22631 18709 30955 11350 14784 26413 26417 WNT%NETPATH%WNT Wnt 12443 54401 18019 13728 19353 216869 11848 18747 11651 18753 18750 18751 26419 16476 19052 17125 16842 18099 22612 16480 26409 226970 93687 13544 12550 13380 208846 67943 20378 14734 16971 16973 26563 18504 23988 19045 21416 84095 320790 77578 18752 12571 20377 20319 20664 13016 21413 22408 22413 22415 22418 14367 12005 14362 14366 14368 14369 14371 84035 330938 84505 18719 IL6%NETPATH%IL6 IL6 13163 26396 15519 17096 14388 14389 107951 13867 54601 18033 13685 12015 14360 19353 13684 16451 13866 17977 18803 433759 15507 11651 11835 18708 18753 15162 328572 56484 14281 26419 16476 26395 14191 19645 19247 18099 26409 26399 56637 20850 20416 20851 12914 20846 26416 22324 56458 18709 19229 54721 21939 229615 15382 16193 12402 16194 20848 16195 12229 26407 26398 12169 229317 20393 12702 14784 26413 26417 TSH%NETPATH%TSH TSH 26397 16001 26399 16846 12912 11928 14674 105782 14672 14673 14677 26417 14678 14679 14681 14828 22095 12317 16150 12330 110157 14682 EGFR1%NETPATH%EGFR1 EGFR1 13196 11949 67941 50766 72621 18596 54135 72201 18643 18738 67451 18805 18806 22038 74155 67760 109135 171463 212139 71889 216190 74255 321022 230837 19084 26362 18759 109333 66898 26400 19108 208618 19211 66166 76179 19246 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 667618 667279 110651 67097 20194 20195 20239 394252 20969 20971 140579 71514 56726 20408 319939 381126 114479 20617 107686 109552 109880 20847 20909 11491 21815 21881 21894 21961 22051 22330 66395 60595 24066 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 107435 30794 12390 56455 109711 54366 19766 101320 29875 22687 73178 29806 208177 232431 54132 194590 66952 23942 14924 21873 225870 333883 20970 98910 238130 17775 330914 78388 50926 26396 72993 13548 433759 14083 18708 12912 14281 16476 20683 18607 20869 22059 12928 12389 26397 56637 218441 18706 13132 71770 56458 18709 26413 54601 16478 17869 12608 20218 67300 12929 26416 13205 13448 19229 286940 11350 232906 16818 16828 17096 17973 18003 11928 18033 18479 20403 11431 18648 240752 18746 18803 234779 170643 18753 18760 59079 23939 26419 26395 93742 140721 15170 19248 19262 110157 19697 53378 230126 22042 22323 22324 22325 22631 108705 640703 72828 227937 208650 11502 54126 19134 68481 13449 13549 26431 12534 105787 108079 20112 13649 13685 14360 606496 16451 13866 12568 20399 18127 12566 15461 18750 16452 12703 14786 20111 58194 16590 56717 20850 20851 13712 19253 30955 12371 26406 666899 16396 26420 73086 14388 54401 13867 12015 19353 12821 109620 13844 192897 11848 17126 17127 17295 18810 22352 74769 18707 18710 384783 16480 226970 12550 18752 13016 54721 229615 15382 26407 12702 105782 54473 53859 12043 20844 100040260 12606 17979 319152 11820 12558 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 14251 74326 236576 24063 24064 57783 21787 67938 108100 24105 70527 12631 20499 229709 107971 327826 19765 20867 399510 56460 69710 232910 12757 73379 19261 71544 12988 216810 13014 12388 218518 74256 11771 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 11657 11674 240753 13855 229285 26936 98432 224650 23943 209039 22378 80794 14302 78757 235406 228136 104831 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 26934 11740 227753 13854 16952 15194 11746 215114 628438 11804 16332 16337 16400 16412 11836 67859 11843 16653 110308 16687 110310 16691 16667 16668 11855 16835 210126 109904 17709 17886 17920 17999 23980 50932 ID%NETPATH%ID ID 15205 18507 19185 19650 66313 26396 21423 11910 12566 19651 17127 21416 13712 26413 26395 26417 19645 13714 13713 14200 110157 15903 17877 IL9%NETPATH%IL9 IL9 26413 54721 26417 20850 81601 16199 20851 20852 IL3%NETPATH%IL3 IL3 56637 17096 20416 14694 14388 14389 12125 12048 14461 20181 56461 54401 19401 12929 20525 216233 18033 12015 606496 13448 56458 22631 18709 18747 12984 14083 14159 18708 15461 18750 12912 12702 18751 26413 18707 26395 19052 15170 12928 16331 19264 100040260 IL5%NETPATH%IL5 IL5 56637 53378 26396 20850 17096 20416 14694 20851 20662 20846 12929 26416 20963 18783 18033 12387 13712 11689 18035 16191 16185 16192 13430 606496 20677 15163 16451 22631 30955 19229 12028 12402 20848 15461 18753 15162 56484 14784 107746 12703 16476 20111 22248 19247 11909 110157 IL4%NETPATH%IL4 IL4 17979 319152 18033 18035 12015 15077 320129 56463 16189 16451 16163 16164 20375 12767 16186 234779 11651 14083 18753 328572 16452 26419 12703 19094 18707 384783 15170 19247 11909 12608 218397 12675 23871 20416 18706 12914 26416 20963 13712 54721 21939 12402 20848 26413 26417 16150 16331 20844 12606 IL-7%NETPATH%IL-7 IL-7 56637 26396 20850 20416 20851 20846 12015 14360 606496 16367 56458 16186 16196 208650 11651 20848 18708 56484 26413 26417 26395 384783 16197 16453 20844 NOTCH%NETPATH%NOTCH Notch 15205 11820 21423 18033 15182 13389 14357 14199 56381 59287 20466 19664 16450 16848 11651 17127 17305 18129 18708 18132 18133 18550 50754 328572 100039623 16452 54485 55927 433586 100042305 19165 19763 27401 17125 22632 16842 208117 270118 60406 66935 21402 20185 20602 26965 103806 18519 56438 19697 56637 20779 20848 26413 26417 IL2%NETPATH%IL2 IL2 26396 15519 17096 14389 18033 13685 16185 14360 13684 667739 16367 16451 16186 12566 11651 18708 12912 56484 26419 74769 16476 18707 26395 18710 384783 15170 19247 11909 56717 12928 64685 56324 110157 16432 23872 18795 19697 14815 16183 16184 16168 230126 23871 22608 20850 20416 18762 20849 20851 18706 21752 20662 22349 17346 27979 12929 26416 12447 13712 22324 18709 30955 19229 12402 20393 12702 14784 26413 26417 12043 16453 20844 16818 TSLP%NETPATH%TSLP TSLP 26420 19697 20850 11651 20848 20849 20851 20852 20846 18034 19698 26416 18033 18035 26413 26419 26395 26417 13684 RANKL%NETPATH%RANKL RANKL 19696 22034 12675 14083 18034 18383 26416 11973 83433 18033 22029 26419 22030 22033 22031 21943 18412 17342 26409 20375 66513 68652 IL1%NETPATH%IL1 IL1 67857 26420 26397 19697 26399 19696 22034 230233 12675 26416 18783 18033 18035 73914 13448 16175 16176 16177 16181 16179 108960 17874 18709 266632 30839 93834 67245 667310 93765 66589 16178 11651 18708 26413 26419 16476 26417 19645 11909 16150 54473 53859 26405 66513 68652 66724 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 216136 12035 12036 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 110208 21351 21881 14751 15277 15275 216019 19895 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 14073 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 22171 270685 13361 238505 17768 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 14430 11676 15277 15275 11674 16548 216019 230163 74246 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 17260 26398 13684 17261 102626 26416 100040260 22034 17164 29857 15507 19094 269881 26415 26399 13712 56613 13631 73086 17346 16177 66513 26407 26409 68652 17347 20807 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 102626 26416 17164 15507 26413 27371 26417 22339 18710 110157 20698 75292 101540 21804 18127 216148 15251 19303 11836 109270 18704 240752 18751 107321 18783 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18708 18709 16542 18803 234779 18706 18750 74769 19353 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 170758 11651 14083 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 16188 16185 20728 16184 17869 16453 83430 384783 16165 16164 17164 67071 16196 16195 16194 16193 12576 16192 13712 16169 12675 16191 12575 17346 16168 16190 16189 332110 11652 110651 17347 20807 26413 26417 110157 18127 11836 18706 74769 18176 109880 11651 20111 50772 56484 23939 16150 20416 56717 18607 16367 16183 20846 20662 20848 12765 13714 227288 56637 23797 20663 237313 20847 16173 20849 60505 16198 13713 20375 16175 14281 16163 16162 16161 20851 100042555 16156 20850 16155 20852 16154 16153 77799 20112 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 54391 319945 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 12892 237926 97541 17025 22275 14151 107508 19044 67417 15288 70383 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 269587 209195 19049 210044 12288 14677 14702 16527 223604 14688 214084 18747 12291 11440 108015 108043 11444 110835 11438 110834 13491 13489 19045 192176 13822 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 17855 20775 68603 14593 56075 110196 14137 16987 192156 100040592 15357 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 68159 242607 108069 108068 243961 20513 22318 74732 53623 14800 14799 110637 140919 14814 58234 14813 20511 14812 20510 14811 14810 20512 216227 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 103711 107272 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 12444 12445 67236 12447 68240 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 19645 18705 20437 18706 11920 12566 74769 19650 18707 26416 18176 29857 19094 26415 12575 11651 11652 18607 18710 23797 18704 240752 225326 12447 15461 22059 320207 22061 12387 22062 19211 19052 19053 30955 234129 18708 16653 18709 12450 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 208967 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 268860 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 15465 16440 14701 16439 14675 18798 18799 18802 14682 74055 16438 114875 14672 14702 18751 14688 18762 18761 18753 18754 18752 18755 18759 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 14672 18749 108071 14816 14814 66168 26556 14813 19108 14812 19084 19085 14811 14810 14809 18751 18747 14805 18798 14682 16438 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 20846 17260 26398 17869 26416 17187 13198 29857 26419 26397 19094 22166 26420 26415 12043 26399 13712 18783 16476 13631 17346 17347 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 18749 19108 210044 14677 14702 16527 223604 14688 14678 18747 66066 11513 15557 19088 19087 15552 15551 15550 14681 14679 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 14702 18751 14688 18762 18761 18753 18754 18752 18755 18759 18430 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 14695 14693 11513 14709 14701 15562 14680 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 242425 16519 12286 54393 12287 224129 11512 11514 11515 432530 104110 14710 14708 14706 14704 14696 14695 14693 14709 18749 19084 19085 210044 14677 14688 18747 66066 12291 11513 19088 19087 14681 14679 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 56791 216080 22210 100041484 66105 100041766 68612 218793 22194 67196 620934 56459 50995 74153 22201 22193 22209 74244 53323 22195 93765 70620 22200 100039535 231380 22213 67128 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 13869 22408 57265 22419 12560 228357 93897 21416 22412 216795 66713 80890 22410 22414 22411 13542 19664 55992 58235 21415 22409 217127 12550 13544 13543 78943 238880 11459 22417 19668 94217 225372 16480 12505 11787 26946 16842 18128 11461 18129 18131 18132 56175 19164 19165 11820 100042305 56637 208117 23821 59287 81601 22063 22067 22066 16971 14725 22068 93735 17356 14367 14365 11464 11465 11475 14314 12387 16974 22415 14362 16973 22413 22416 14366 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 56847 56752 14204 11671 110695 11668 11669 212647 11670 72535 17161 107747 109731 216188 19378 237320 69748 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 22059 22061 26374 22062 17246 17248 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 216136 12035 12036 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 68738 60525 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 68087 211347 106564 269614 74450 75735 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 11428 64602 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 26416 29857 19094 26415 12675 16440 16439 26413 26417 16438 110157 11836 26419 26420 18751 16476 15461 18753 19354 30955 234779 18706 74769 19353 18707 26395 26396 18176 26414 57257 15170 17096 16150 22325 26405 19264 26406 22324 640703 20963 20662 18038 17060 12229 14784 12518 12478 15985 20663 12483 19055 19056 18035 14281 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 23797 13685 22084 19082 105787 64930 108079 19079 108097 18518 11651 22059 58988 22061 11652 22062 19052 19053 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 16956 239759 18796 85031 18797 269060 18795 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 29858 54128 110119 218138 69080 331026 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 22184 66585 70767 53607 20639 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 12914 19885 23797 56551 112407 112406 15251 11863 22346 22166 11651 11652 56717 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 29807 105663 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 12914 20021 66653 22130 74238 72308 21343 328572 71828 229906 235459 24074 83602 100043714 407786 74044 66420 19183 21374 227606 208677 26427 208647 78284 63856 228980 319944 14884 19084 68705 19085 98053 14894 68153 74197 69833 245841 237336 14885 209357 21341 108143 66464 19088 68776 19087 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 210044 14697 14710 14677 14700 14702 14708 14706 14688 14704 14696 14678 14695 14693 11513 14709 18386 14701 18976 14681 14679 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 13088 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 14583 14584 76355 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 11998 18429 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 14645 266744 14661 UNTITLED%PANTHER PATHWAY%P00019 untitled 18796 18797 18795 16440 16439 14675 11652 18798 26413 14682 26417 16438 14672 18749 110157 18127 19084 19085 210044 11836 18751 18783 18747 18762 11513 18761 19088 18753 19087 18754 18752 18755 18759 14680 104111 19091 18750 54195 224129 60596 11512 19092 11514 13617 26395 11515 13616 26396 13615 432530 13614 104110 271639 13618 234889 11651 23797 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 15186 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 14287 22171 13361 14528 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 15560 14695 15559 14693 15558 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 14702 18751 14688 18762 66066 18761 18753 18754 18752 18755 18759 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 109905 223272 215449 286940 104303 228998 11858 140579 11840 12945 57342 16403 109700 16398 11845 14268 373864 53867 104099 381924 16407 16409 74194 11848 223881 217378 16400 11852 16401 11853 16402 16404 72065 192897 16419 74192 20130 238880 26408 19229 16408 12818 16421 16410 12816 16412 12927 12835 12834 12833 11461 57764 22323 67771 11867 56378 73368 14360 76709 16420 21894 12817 71302 12815 192176 12814 12813 16411 56443 16414 12821 107581 12819 140580 13196 12829 12828 20779 12827 12826 12825 26414 26405 26406 26398 26415 26407 26417 18710 110157 19303 11836 26419 18704 26397 240752 26420 225326 15461 19354 30955 18708 18709 18706 74769 19353 18707 26395 26396 18176 109880 12824 107746 14083 16399 16202 50772 12843 23928 330662 320910 20416 22330 12389 12929 76108 12928 74012 20662 12839 329941 12837 12832 12988 12831 16773 20663 94216 12830 16774 241226 60595 213119 225341 109711 11472 19248 16779 16780 226519 170736 11465 16772 16782 78514 12841 12840 16775 16776 16777 319480 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 17869 16453 67071 12675 332110 11652 110651 71302 218397 17973 18590 18591 18595 14390 76117 68797 19326 26414 71544 57257 14247 232441 18596 22325 259302 26405 71520 216445 17444 22324 69257 13709 17974 606496 94190 13710 14784 78177 75415 13876 13875 171207 11855 11856 320119 13711 56501 27049 30051 13661 56309 260298 22282 18080 58988 54153 320207 230233 16451 14389 114713 14388 20418 109333 16452 117600 17164 13712 56613 73086 17346 16440 26407 16439 17347 20807 26413 16438 26417 18710 110157 216148 11836 26419 16476 225326 15461 30955 18708 18709 18803 234779 18706 18750 74769 18707 26395 26396 18176 228359 109880 73167 23871 20111 50772 23939 16150 20416 18607 20846 20662 20848 13714 56637 20663 20847 20849 14281 20851 78514 20850 20852 20112 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 63993 20508 102857 667772 432516 17913 504186 54130 226977 17909 360013 11443 213603 110902 11435 17910 338367 71602 17918 17919 17920 17921 17922 270163 246177 17916 11449 208943 11448 11447 17912 244281 217198 231252 74376 667663 238880 17879 11459 544791 77579 17880 17882 17883 17884 17888 140781 17885 17886 71960 11461 329421 11440 108015 108043 11444 110835 11438 110834 11464 11465 11475 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 20846 20848 16453 20851 16451 20850 20852 20849 16452 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 192136 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 236539 100678 107272 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 18803 234779 18706 74769 19353 18707 18710 18704 240752 57764 22323 107449 69581 320207 18209 226251 18021 73181 22253 19354 18208 30955 18019 18708 80883 18709 13176 210801 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 229706 102680 214084 22598 381884 110877 13162 103098 20538 74338 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 13087 14262 21743 22236 394433 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 192136 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 238505 11720 232087 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 11853 667663 238880 17879 11459 544791 77579 17880 17882 17883 17884 17888 140781 17885 17886 71960 11461 329421 67771 11867 69581 56378 76709 19354 56443 19353 100042651 214230 107589 19877 18479 18481 68089 224105 22151 241656 22154 54004 18643 70584 18645 75477 213435 19878 22152 227613 22153 12632 12631 16765 228785 73178 67951 56471 73710 545486 13367 16885 11464 11465 11475 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 384783 26395 26396 67071 218397 13712 56613 73086 20111 110651 26413 16367 26417 20662 110157 20663 26397 16004 16370 14281 16002 16001 16000 58988 16334 16337 23920 20112 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 20846 15978 16451 15979 15980 16452 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 13195 21990 216343 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 68556 76654 18103 79059 56520 66757 331487 80914 22245 22271 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 53611 56216 20907 14697 12295 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 18749 108071 14816 19108 19084 19085 14677 14688 14678 18747 19088 19087 14679 12286 12287 271639 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 242607 20513 22318 53623 14800 14799 110637 14814 14813 20511 14812 20510 14811 14810 20512 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 26398 100040260 11798 12018 228355 12675 19697 19698 13804 26926 12028 13665 26400 11652 11910 11911 223922 26413 19696 71609 26417 14082 23992 21926 14939 225028 16994 53859 26408 12125 14102 14103 12048 19106 11783 26419 16992 26397 12367 12124 26420 13163 18751 12043 26401 66593 16476 21937 21938 22035 226641 18761 26412 18753 14943 18754 18752 81703 18755 12369 12370 12915 30955 11909 19766 11797 670717 12905 22030 18706 18033 18750 18034 74769 26921 21933 18707 11796 12371 11651 26414 16150 23797 18035 16004 14281 22059 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 12035 12036 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 26398 102626 26416 17164 67071 29857 19094 26415 26399 13712 11848 26407 26400 110651 11852 20807 26413 11853 26417 110157 11836 26419 26397 26420 26401 16476 225326 15461 19354 30955 11909 18706 74769 19353 18707 18805 26395 18806 26396 56044 64143 18176 19731 66482 19730 109880 21844 23871 170758 18479 11651 18481 20111 26414 224105 20416 18607 20846 20662 20848 606496 14784 56637 23797 20663 16653 20112 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 18750 18796 26395 18797 26396 18795 14697 14710 14700 14708 14706 110355 14704 320129 14696 13712 13653 14695 11606 14693 11607 14709 109689 216869 16440 16439 26413 14682 26417 16438 110157 14688 66066 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 20021 66653 22130 74238 72308 21343 71828 229906 235459 24074 83602 407786 63856 228980 319944 14884 68705 98053 14894 68153 74197 69833 245841 237336 14885 209357 21341 108143 66464 68776 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 22030 18706 11920 12566 12914 17246 17248 328572 12575 11651 20610 100043429 29870 17873 11652 13197 18519 22427 433759 18607 20466 23882 12532 23942 50883 18854 100043858 93759 12578 23797 55948 12534 434174 12447 22059 22061 22062 19211 234129 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 18796 18797 18795 14697 12295 14710 14700 14708 14706 12290 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 14702 18751 14688 18762 18761 18753 18754 18752 18755 18759 18803 234779 12286 18750 12287 20614 22320 20619 67474 22319 22317 22318 12296 20908 22044 22045 22094 12640 12297 12298 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 20652 15486 15487 16889 15485 27400 13075 223920 15490 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 66713 22410 22414 22411 21415 22409 12550 238880 11459 22417 16842 11461 12387 75599 93701 93706 54216 19246 233651 93893 93889 270120 93886 93891 18526 93887 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 93873 353237 353236 73173 192164 353235 170677 12939 12937 12941 18163 12388 12936 192163 353234 93881 116731 12558 23836 279653 245578 215654 320873 12565 12564 241201 12563 93872 12562 93724 12561 12552 268663 18530 211712 245827 14107 12557 12556 12555 12554 22295 219257 239096 11994 14158 104010 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 93735 14367 14365 11464 11465 11475 14314 22415 14362 22413 22416 14366 UNTITLED%PANTHER PATHWAY%P06664 untitled 19697 20482 21815 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 76507 237940 11754 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 17449 18598 66052 12974 14194 18293 18604 56451 11429 18597 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 11947 11949 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 242669 18263 54375 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 66904 17850 52665 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 79464 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 103149 104776 22240 12934 64705 268860 23959 72269 99586 65254 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 66646 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 18749 19108 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 18747 14695 14693 11513 14709 11554 19088 14701 19087 14680 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 606496 18706 56637 384783 17246 17248 22084 64930 16004 16370 16002 16001 16000 16334 16337 23920 56458 56484 19211 234129 18607 16367 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 18749 19108 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 18747 14695 14693 11513 14709 19088 14701 19087 15466 14680 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 14695 14693 11513 14709 14701 11556 14680 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 14544 11717 23959 22436 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 238505 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 14672 14697 14710 14700 14702 14708 14706 14688 14704 14696 14695 14693 14709 14701 18976 14675 12922 14682 12921 14680 12918 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 225724 319924 11784 12289 18750 54652 12292 74764 26416 57267 320795 16594 263803 29857 12295 232943 16593 19094 11491 26415 26414 50772 332110 23939 26413 26417 100042305 208117 23821 59287 81601 12296 12288 26419 26420 18751 18762 56175 18761 19164 18753 19165 18754 11820 18752 18755 18759 109333 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 12411 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 19353 12767 19876 57764 20563 11350 20564 20562 20315 18209 19354 18208 11853 80883 13176 117600 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 18103 79059 56520 114873 51797 227231 56749 69719 55936 18102 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 26398 26416 13869 29857 19094 26415 26399 26407 26400 11652 26413 208177 17532 26417 13649 210710 13867 110157 13866 69601 75292 236576 20130 101540 226525 26408 24066 24064 216148 18015 24063 66922 11836 23980 26419 73523 26397 18704 240752 26420 18751 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 18760 218397 109880 11651 26414 20416 26405 71520 26406 20846 20662 20848 23797 20663 20847 20849 320207 54153 20851 20850 14389 114713 20852 14388 20418 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 99571 14161 18791 18792 18793 18815 18787 17392 18788 18816 17386 83995 110135 17395 PNAT%PANTHER PATHWAY%P05912 PNAT 269587 13162 20614 22320 14706 20619 14704 67474 14696 22319 14695 22317 14693 14709 22318 18749 19108 209195 19049 210044 20908 14677 16527 223604 14688 214084 14678 18747 66066 11513 19088 19087 19047 13491 13492 14679 13489 13488 19045 14687 192176 13823 13822 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 103583 24069 20423 12234 269209 12914 14634 19206 14632 319757 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 63993 20508 16519 102857 14686 16521 14697 16522 271639 14710 16524 14700 14685 14708 12672 14706 243764 14704 14696 14695 14693 14709 18749 19108 19084 19085 14677 14688 14678 18747 66066 19088 19087 14681 14679 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 245847 67980 26384 74091 14583 14584 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 55994 21808 14573 238057 319618 14560 12914 11477 26416 11479 11480 11481 11482 29857 14106 14283 19094 75788 24087 26415 21892 14561 12153 20481 328572 66513 26409 26413 26417 20130 26419 26420 16476 15461 11909 18176 16477 20482 16478 26414 12154 16326 12163 12156 13590 110075 76793 12159 12160 12161 12162 12166 12167 23886 12168 14563 12155 17125 14562 17126 17127 17128 14566 17700 16325 12165 16324 18119 16323 110542 12705 320202 21809 21812 21813 17684 66313 242316 269275 17129 17130 17131 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 22371 21788 21824 16399 14060 58992 14724 14723 385643 14058 14071 14069 217847 66901 19123 54368 19128 14729 14062 19124 14065 14068 14066 16621 14061 99571 14161 18791 18792 18793 18815 110135 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 18706 74769 14686 14697 18176 14710 14696 14695 12371 14693 11651 56484 14675 11652 18607 14682 16367 18710 20662 14672 56637 23797 18127 20663 14699 14677 19216 54601 22631 14688 14678 58988 320207 16337 56458 14679 18708 18709 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 109905 215449 14823 108073 268934 210044 14677 14702 14688 18747 13491 13489 13492 13488 16521 16522 16524 12672 243764 108069 108068 640703 606496 12914 14710 14700 14708 14706 14704 14693 328572 14709 15465 14701 208677 18749 26427 208647 108071 78284 14816 19084 19085 14699 20605 20607 20606 15566 14678 15565 15563 11513 18682 15557 67300 19088 74325 19087 18386 12757 15552 14715 15551 20609 15550 20608 14765 14679 11539 11540 15562 11541 14680 18387 110078 16519 18389 104111 110095 19309 12671 224129 11542 11512 12669 11514 11550 11515 12913 432530 213788 104110 232493 14936 225192 17773 244701 18679 110094 15560 102093 15559 15558 99296 11552 11553 11548 11549 18390 12912 11555 68961 56637 11554 15466 11556 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 26398 26416 29857 19094 26415 26399 26407 26400 11652 26413 26417 110157 236576 26408 24066 24064 24063 11836 23980 26419 26397 18704 240752 26420 18751 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 218397 11651 26414 15170 20416 26405 14182 71520 53608 26406 14186 14183 14184 107971 20662 327826 23797 20663 54153 114713 20418 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 109900 18416 217214 11898 227231 69719 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 14697 14710 14700 14685 14708 14706 14704 14696 14693 14709 14701 640703 64337 212541 24013 225600 14699 12790 12788 70405 14702 30952 19674 20028 14688 19739 18587 18588 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 12035 12036 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 100226 12361 50873 53331 26443 67847 13162 26444 26416 19170 18806 18000 26440 19166 29857 19167 26441 26442 171469 72900 54401 13712 54204 14763 26414 332110 23939 26413 26417 55948 26419 22631 26420 12447 20617 19171 18951 18952 100039786 21823 26446 12448 22628 22627 19177 22629 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 63993 20508 18750 12671 12669 320795 263803 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 16440 16439 14675 18798 14682 16438 14672 14814 14813 14812 14811 14810 18751 14688 18762 66066 18761 18753 18754 18752 18755 18759 109333 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 210044 14697 14710 14677 14700 14702 14708 14706 14688 14704 14696 14678 14695 18610 14693 18619 11513 14709 18386 14701 14679 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 327762 15081 106344 18971 72151 18972 19075 19891 21973 21974 18538 19687 19718 18968 69263 319152 21969 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 73724 110821 66904 17850 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 18103 79059 56520 114873 18102 56248 171567 108147 100042069 11565 14923 11564 11566 20135 20133 231327 75533 382985 11636 11637 229949 635960 229363 14450 54369 68870 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 19401 14060 20181 22337 14473 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 109905 215449 18796 18797 18795 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 16440 14701 11848 16439 14675 217378 18798 14682 16438 14672 108071 14816 14699 14702 20605 18751 20607 14688 20606 18762 18761 67300 18753 18386 74325 18754 12757 18752 14715 18755 20609 18759 20608 14681 13491 13489 13492 11539 13488 11540 11541 18387 19395 18389 93690 12286 18750 233046 12061 12287 12671 12062 11542 99326 12669 19419 240168 110351 213788 16801 12672 243764 18390 108069 108068 64337 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 22418 22422 22421 22408 57265 22419 21416 22410 11848 22414 13542 11652 19664 11852 11853 22409 13544 13543 19668 18128 26401 18129 18132 18805 18806 20779 13449 13388 50915 11799 218397 14786 17973 13448 18590 14164 18591 16449 18595 13389 27261 13386 13837 12005 78390 13845 54635 18596 13844 270190 71520 21414 23805 232889 16450 17974 21687 11600 71785 54485 11789 13642 13641 16451 12387 26398 102626 26416 17164 15507 26413 27371 26417 22339 18710 110157 20698 75292 14062 101540 21804 18127 216148 15251 19303 11836 109270 26419 18704 240752 18751 107321 18783 16476 18762 225326 15461 18761 18753 18754 18752 18755 18759 30955 18708 18709 16542 18803 234779 18706 18750 74769 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 18479 11651 18481 14083 224105 20416 14182 12929 12928 20846 107971 20662 327826 20848 56637 23797 20663 14281 14367 14365 14362 22413 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 20135 20133 18103 79059 56520 382985 66757 114873 22171 21915 110074 18102 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 56216 70450 20907 19339 22249 20910 20614 20979 229521 54524 171180 53420 22317 13852 208898 54525 319508 20981 20980 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 54401 11848 12028 110651 12550 53859 19229 12048 16410 16412 14702 12367 12927 18792 14688 214084 18747 17392 11909 20779 13653 216869 26414 17096 640703 14784 19055 18035 13685 12387 252972 20613 19247 26403 14919 667739 16452 18125 233979 12759 17260 12424 26398 12426 13684 110596 17261 22026 15568 26416 12326 21413 22034 20192 20191 11640 15507 20190 23938 67605 20687 26399 12494 13712 56233 20683 22612 19225 19016 15937 12015 14459 15200 20807 26413 16438 26417 18749 110157 101540 19303 11836 26419 18751 26420 12043 18783 16476 18761 18753 18754 18755 18019 18708 18803 18750 19091 74769 19353 26395 26396 432530 18760 109880 19877 18479 11651 14083 20111 56484 23939 12912 20416 18607 16367 12928 20662 20848 13714 18263 56637 14281 56458 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 12183 18746 18655 21991 18641 216019 14751 15277 15275 18642 56012 11674 13806 13807 100043349 18770 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 16450 54485 18222 66935 103806 19668 20602 18128 18129 18131 16449 18132 13389 13386 19664 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 268860 14417 14415 246277 214579 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 26398 12371 26414 14082 26408 14102 14103 11783 26419 16907 12367 13368 20259 26420 13163 14084 12368 16476 235587 11546 16905 16906 11545 328417 12332 12633 12369 227753 12370 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 12361 12767 12675 19697 19698 11848 11652 11853 74192 20130 238880 11459 19229 16408 12818 16421 210044 12816 14677 16412 14702 12835 12834 12833 11461 18747 67771 11867 56378 73368 76709 56443 18034 16477 16478 71520 22324 16452 16653 18796 18797 18795 14700 14708 14706 14704 14695 22371 14709 16440 14701 16439 14675 18798 18799 18802 14682 26413 74055 16438 26417 114875 14672 18749 110157 667663 17879 544791 77579 19108 17880 17882 17883 17884 11836 17888 140781 17885 17886 18751 71960 329421 16476 14678 18762 18754 18021 73181 14681 56212 19354 14679 30955 13051 18019 12769 18018 56744 18803 54199 234779 14294 18706 14293 12273 74769 15975 224129 54446 19353 18707 11512 15945 20303 20304 20306 20296 18176 20292 277360 57260 20293 23832 20302 214230 12777 107589 20297 19877 100038965 18479 12772 11651 18481 20299 12768 68089 224105 12766 12145 80901 241656 16150 20312 20416 12776 12775 18607 12458 70584 12774 16183 12773 12771 213435 20662 12322 20848 108058 12765 227288 23797 228785 11464 11465 11475 15978 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 18950 15452 14544 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 13424 66445 11771 26398 11772 234663 12337 12914 545156 15194 14447 68097 268958 20430 12339 23830 269881 12064 20683 328572 66713 26400 100043349 21374 74192 238880 11459 228980 11783 12367 26420 11461 16476 67771 11867 74325 12370 56212 19354 56443 19353 14809 100042651 14807 14806 14805 22151 22154 110637 22152 227613 14814 22153 56455 381917 14813 110350 215114 14812 432611 13385 14811 67951 15114 14810 235661 73710 13191 545486 73647 69543 104215 110082 14281 12333 12334 12335 12336 22059 11464 12338 11465 13417 22061 11475 54152 22062 29816 13427 13426 73916 100042162 80837 76884 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 94041 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 69634 18534 18746 18598 18563 104112 17436 12974 18770 18597 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 12675 19057 16797 12500 12501 12502 11652 12503 16822 22637 26413 16818 12487 26417 12519 16438 12524 18710 110157 11836 26419 26420 26401 16476 225326 15461 18761 30955 18708 18709 18803 18706 74769 19353 18707 26395 26396 18176 109880 17973 18479 11651 18481 224105 57257 16150 22325 19264 17444 22324 640703 20662 17974 23797 20663 19055 19056 18035 14281 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 26416 26395 26396 22034 13712 12675 66513 26409 16150 26417 21353 16179 21899 21898 142980 225471 24088 26410 56480 26940 170744 18035 26419 266632 26397 81897 17874 26420 56489 117149 18037 16476 54131 106759 54473 170743 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 216134 103711 107272 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 19057 14702 14688 67155 93761 20586 20585 20439 20588 20587 13001 13000 73016 103583 21372 70425 103236 12234 27373 104318 93687 140577 75560 12385 12386 68058 93762 216033 54380 59036 77578 20215 68094 83796 83797 57376 66993 68142 100043597 226849 225849 26931 21770 26932 84035 19058 19059 114606 170735 70315 81004 18099 93760 17125 15183 21885 21886 54366 17128 21888 21887 68911 15182 15201 72135 12387 19052 19053 17129 20437 18796 18797 18795 14700 14708 14706 14704 14696 14695 14693 14709 16440 14701 16439 14675 18798 14682 16438 14672 18021 73181 18019 64337 93735 14367 14365 14314 16974 22415 14362 16973 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 22410 22414 22411 13542 21415 22409 12550 13544 13543 22417 16842 109689 216869 12005 433759 19055 19056 75599 93701 93706 54216 233651 93893 93889 270120 93886 93891 12914 18526 93887 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 328572 93873 353237 353236 73173 192164 353235 170677 12939 12937 12941 12936 192163 353234 93881 116731 12558 23836 279653 245578 215654 320873 12565 12564 241201 12563 18751 93872 12562 93724 18762 12561 12552 268663 18761 18530 18753 211712 18754 245827 18752 14107 18755 12557 18759 12556 12555 12554 22295 219257 18018 239096 11994 104010 18750 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 56637 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 11486 11821 18950 15452 22436 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 15450 16890 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 12286 12287 56216 14686 20907 14697 12295 271639 14710 14700 20614 14708 22320 14706 12290 20619 14704 67474 14696 22319 14695 22317 14693 14709 108069 108068 22318 18749 19108 19084 19085 14677 14688 14678 18747 66066 19088 19087 14681 14679 UNTITLED%PANTHER PATHWAY%P05916 untitled 18387 210044 14697 14710 14677 14700 14702 14708 14706 14688 14704 14696 14678 14695 18610 14693 11513 14709 14701 14681 14679 11998 18429 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 19353 16801 65254 12934 64705 18479 20354 14302 11848 18186 14360 18844 235611 26757 20346 19354 14159 12568 12933 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 12286 108071 12287 14816 18796 18797 18795 14710 14677 14708 14706 14688 14704 14696 14695 12291 66066 14693 14709 14681 14679 12801 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 21340 227606 21339 21429 17749 20018 63856 19285 106298 20017 22130 237336 21341 19183 21374 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway 216134 103711 SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 66757 21877 72269 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 18749 19108 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 18747 14695 14693 11513 14709 19088 14701 19087 11555 14680 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 14697 14710 14700 14708 14706 14704 14696 14695 18610 14693 18619 14709 14701 18390 12912 18749 19108 210044 14677 14702 14688 14678 18747 11513 19088 18386 19087 14681 14679 14680 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 27053 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 14672 18750 18796 18797 18795 11551 11552 11553 11548 18753 11549 18754 18752 18798 74055 16438 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome 110391 20751 13361 11677 12408 19286 320415 14528 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway 100038824 11606 11421 ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway 16542 THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate 55951 269951 112407 112406 66945 18563 67834 27376 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway 15452 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway 14815 15519 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway 21939 21947 12675 230233 26416 26401 22034 18033 18035 16151 16150 22031 19252 21929 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism 224020 228550 83493 56717 56208 18711 16329 71780 55980 66461 74769 56727 234729 269180 75669 69718 18798 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway 100038824 11606 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism 110006 223337 70974 14936 72157 11722 77559 14387 216558 22235 110095 14751 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway 11670 107141 11668 14863 13114 13088 13087 72303 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 98314 216456 269951 66945 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 14661 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency 110006 22239 15275 14751 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway 18750 18803 18751 20963 19353 16818 14784 16797 20416 26419 14281 110157 13712 15461 16476 26401 18708 26400 18033 14360 18035 26395 12313 19055 19697 26417 320139 19419 54446 22190 12502 12503 19056 12500 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway 26357 18984 624814 18671 17250 22436 105349 19765 18104 75406 18127 58810 109857 12780 12408 70840 226646 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling 27053 11833 104174 14661 15109 13382 216456 227231 231691 66514 434437 14645 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 18750 18795 18751 12289 54652 12292 26413 110157 15461 12288 18033 18035 26395 16438 19697 26417 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway 20927 16334 12286 20526 56808 12295 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor 18750 18795 16438 14682 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism 18718 224020 103199 18795 16331 13649 56208 52858 18711 18704 225326 13866 18707 18720 228361 234515 234729 75669 18708 19211 64436 104015 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis 671878 18263 232087 20810 108645 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism 100038824 11606 11421 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation 14651 109801 52815 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway 63959 434203 13178 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 13077 58226 394433 11928 71853 18747 69191 16521 12846 67838 98660 394434 16535 12304 12291 394436 16493 19035 330953 64136 16523 12282 20927 67397 16514 14828 20271 22004 13849 16519 94284 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 107141 13114 18104 13383 16511 20191 20928 246133 13106 232975 19084 20649 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) 110446 15107 11409 15108 52538 93747 11363 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine 20115 319195 67248 100043391 97541 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway 224814 76408 12575 12780 18671 17250 545486 19765 22143 22059 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease 16922 11671 26874 11666 26458 56794 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway 100038824 11606 11421 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis 22173 13190 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway 13114 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway 100038824 11606 11421 INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 14701 14688 14309 12640 210044 18749 19045 12912 14699 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency 21823 18948 13195 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism 117147 107146 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle 11826 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism 55980 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) 110911 66586 52123 66461 14732 74451 14555 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway 20517 12780 13114 13088 56448 394434 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms 12753 18160 18626 27373 12952 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway 18750 18803 18751 20963 19353 17060 16818 14784 17096 15985 20416 109305 26419 14281 110157 13712 15461 16476 26401 26395 12313 19055 26417 54446 19056 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins 14688 22141 18795 12669 15560 14699 14682 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine 20115 319195 67248 23874 66590 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway 100038824 11606 11421 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway 13077 13114 13087 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 94284 20859 14871 27416 239273 231396 20860 20887 26357 56448 18671 17250 13106 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation 12039 12040 66904 110821 13171 13382 231691 17850 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway 71519 14775 208285 17001 19223 13850 13114 100040843 13088 13110 16993 11684 394434 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 56448 12408 72303 14598 13106 72054 66469 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 234734 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway 224814 76408 12575 12780 18671 17250 545486 19765 22143 22059 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain 66043 11950 14571 17708 66945 11947 670717 100039108 66925 11949 22273 54405 100043349 11739 14385 17705 11946 67680 66052 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism 56316 18104 27973 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway 20266 20264 13077 13114 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism 69019 110948 100705 26363 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway 100038824 11606 11421 OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism 11677 72157 74246 14430 226413 216558 12091 14387 11605 15275 14377 14595 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway 11670 13114 13106 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism 228550 71780 55980 234515 217837 75678 269180 23827 17330 56409 27399 170835 69718 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism 110446 15107 11409 93747 15356 117147 67041 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway 110446 68603 100040592 319554 14137 16987 192156 15357 17855 110196 20775 BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I 18746 21991 100043349 56421 14751 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis 18777 12660 14571 13026 192654 19210 52858 12647 56209 13139 18618 66461 14732 74451 14555 66586 19012 320951 18782 237928 74596 18806 55979 27388 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway 11537 109828 230558 12279 15139 14962 18636 12266 12274 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway 107141 13114 56448 15567 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism 11605 268656 14466 22239 18605 22234 20773 67630 53418 56632 230379 242285 223753 70059 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) 110391 20751 13361 11677 12408 19286 320415 14528 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides 20656 667310 12359 22178 20657 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway 100038824 11606 11421 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect 69719 55951 13806 104112 66945 67834 64602 66925 18663 20501 20916 12183 14194 15275 18293 27402 15926 11428 15929 14751 14447 17449 18746 67680 239606 66052 12974 18642 12040 19895 14661 14782 14660 100198 21351 110208 83553 11676 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway 13114 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway 224814 76408 12575 12780 13114 18671 17250 545486 19765 22143 22059 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway 18750 18803 16337 20851 26413 16367 16334 15170 12703 20528 14784 14600 20111 20416 20662 20850 16452 110157 15461 26395 26417 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct 20276 11931 11932 20277 11933 11928 98660 11827 110935 27411 20533 100038824 11828 12346 20278 232975 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle 14571 100043349 14555 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia 110391 20751 13361 11677 12408 19286 320415 14528 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism 225326 18707 74055 66461 101490 234729 75669 16332 218441 277360 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine 20115 22321 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) 13163 12368 19090 16905 16906 14082 12633 26409 18479 11545 11857 12370 12367 13347 19645 26419 12369 26398 19249 224105 16907 26401 16476 13368 14102 20740 14103 192656 14084 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I 76282 11611 55951 18563 224805 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle 19895 21991 66646 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway 13867 18750 11491 19164 100042150 13869 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway 100038824 11606 11421 FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway 71519 14775 208285 17001 107141 19223 13850 13114 100040843 13088 13110 71853 16993 69191 11684 67838 106648 394434 105349 12304 64292 394436 19215 19035 11689 64136 11686 12282 21391 67397 11687 14828 11688 19224 19225 18399 22236 19879 12408 71773 72303 14598 13106 72054 66469 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule 30962 20532 54403 20544 11826 69354 50934 18399 20510 12346 102680 20518 20540 330836 17254 20539 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway 18803 13856 13857 15170 14784 20416 20662 26419 20850 14281 16452 110157 13712 15461 16476 26395 26417 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway 13114 56448 18390 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway 11421 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway 14381 18641 19895 72157 66646 230163 21881 232449 19139 66171 14751 14121 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development 18091 14463 20807 74318 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency 14415 268860 104776 11669 64705 99586 11754 103149 338403 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell 14688 56508 18750 22318 18795 16440 19339 55984 14652 271639 12286 20526 20927 14702 56808 14682 12671 12295 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 14688 18749 19045 12912 14699 15565 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway 107141 13114 13088 56448 72303 18390 13113 14811 14810 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism 107869 216443 232087 20768 23971 269378 67547 67011 14598 12411 50880 108645 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 14688 19214 210044 18749 14699 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism 66681 14376 14936 216019 15275 74185 14751 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling 14688 18795 11651 19877 432530 78134 20807 16438 14702 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism 29807 105663 116914 66566 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 ARGININEMIA%PATHWHIZ%PW000183 Argininemia 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 18750 18795 110157 18751 15461 18033 18035 26413 26395 16438 19697 26417 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway 11670 12359 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 68738 60525 72535 11669 13106 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 18750 18803 26413 20851 16334 16367 15170 20528 14784 14600 20111 20416 20850 16452 110157 15461 14599 26395 26417 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism 76282 11611 55951 18563 224805 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III 72157 74246 67883 14430 216558 22235 103988 14635 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway 18750 18795 18803 11651 22324 30955 104709 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging 192185 19017 226518 93759 12753 59027 18160 66454 18104 74080 19883 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 14688 18749 15566 19045 12912 14699 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway 14815 15519 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway 107141 22236 19879 13114 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 19224 19225 71773 18399 72303 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis 18746 18648 21991 15275 100043349 13806 56012 319625 20525 56421 14751 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway 107141 20538 13077 13114 56448 15567 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 100040287 16520 19088 11554 215999 16518 67821 12288 19085 20541 19087 20650 56543 16525 16509 56808 12295 18749 20544 13383 16511 20191 20928 246133 232975 19084 20649 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13077 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway 14262 394433 13088 13087 11761 11444 110834 11438 394434 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis 20425 56752 170442 73251 192289 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway 11636 18103 18102 11637 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism 107869 14630 14718 14629 12583 83429 27267 246221 16828 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway 18750 18803 13649 18751 14784 20416 26419 14281 26398 110157 13712 15461 26401 16476 26395 26417 20807 20847 20846 20848 16451 100039026 13645 20662 218397 20852 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) 107869 12411 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism 57028 216134 11647 103711 11761 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism 72157 74246 67883 69976 14430 216558 22235 15275 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway 100038824 11606 11421 PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 216443 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway 434203 104158 72269 72962 22171 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism 18605 22173 54391 319945 11431 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 71853 69191 67838 98660 394434 12304 394436 19035 64136 12282 67397 14828 231396 56808 12295 22236 12286 13162 71773 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 110446 15107 11409 15108 52538 93747 11363 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis 19012 14712 99712 228061 55979 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency 58250 54200 20887 23827 211389 23972 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway 100038824 11606 11421 CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway 15466 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway 19224 19225 13114 56448 394434 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway 11636 18103 18102 11637 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation 20537 11931 11932 58866 11933 11928 103988 98660 20526 232975 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway 109731 107141 17161 56448 15567 11761 13113 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle 76282 69354 55963 68267 14661 108682 20526 20528 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway 63959 434203 13178 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect 55951 100043349 216456 13806 56012 66171 18655 18770 16828 20514 66945 18563 67834 56451 66925 20501 209692 20917 11429 13382 14194 230163 235339 21881 20526 68263 15926 170718 11428 18597 14751 15929 78920 14381 17449 18641 18746 67680 66052 12974 19895 14661 15277 21351 110208 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway 11421 TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect 55951 18598 229699 20511 74419 100043349 216456 13806 18655 66945 67834 18563 56451 209692 20917 11429 14194 13382 235339 68263 170718 15926 56421 11428 14751 17449 14381 18746 67680 12974 14661 19895 15277 21351 110208 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) 66234 235293 18194 98386 13121 13360 15490 13595 74754 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway 56717 26413 54721 20848 16451 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway 104158 12038 436059 18390 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism 69718 56208 225326 71780 55980 66461 234729 242291 18706 104015 18798 12462 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway 670717 19353 19765 18706 11783 57257 11848 12675 12371 110157 56044 13712 54601 15461 11651 18805 19730 12048 17127 17128 26395 12015 26417 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis 14688 13070 11607 13079 15497 14702 14682 13072 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis 21823 18948 13195 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway 13649 26357 18671 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria 107869 14630 14718 14629 12583 83429 27267 246221 16828 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway 16416 16399 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway 11421 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling 14688 18795 11651 19877 432530 20807 16438 381810 14702 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway 11670 11668 13114 13088 13087 72303 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) 14652 227289 20494 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling 56458 384783 18607 16337 26413 16367 16334 20528 14784 20416 20662 26419 110157 15461 11651 26395 30955 104709 26396 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 107045 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism 69718 327655 71780 55980 242291 56409 27399 104015 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid 17449 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism 56208 18802 225326 55980 234729 75669 104015 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway 16416 16399 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway 70839 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System 210044 18749 13488 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action 20608 12346 15466 11944 11945 20604 14459 12426 12671 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway 107141 13849 13114 13088 72303 13113 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway 12043 12566 12534 12447 13555 17873 12443 18538 12028 11783 19645 12567 12575 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway 230558 12279 15139 14962 12266 12274 11537 12258 109828 625018 12259 12260 12262 667277 317677 12263 17195 17175 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway 19166 19167 26441 56424 26442 22194 23997 24108 19185 22201 26445 26446 19172 19173 19175 19177 67089 26443 26444 19170 19179 22190 19181 19182 23996 19184 26440 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway 18750 18795 18751 14784 26419 110157 13712 15461 60595 16476 26401 14714 18805 14715 26400 14672 17390 26395 224129 12322 12313 17387 14308 16866 13869 20779 11911 13653 12640 242274 12540 15200 26413 16438 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism 17960 13077 13114 13087 72303 22436 13106 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis 18746 15277 100043349 13806 56421 14751 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway 18750 18803 18751 20963 19353 17060 14784 17096 15985 109305 20416 26419 14281 110157 13712 15461 26401 16476 26395 19055 26417 19056 12229 12518 18021 73181 18018 18019 20662 19057 640703 22324 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling 14688 18795 14745 11651 19877 432530 20807 16438 14702 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism 110446 71911 15356 67041 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway 17523 13114 21973 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis 12660 13026 68671 18618 320951 99712 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism 224020 228550 83493 56208 16329 71780 228361 55980 66461 217837 56727 234729 75669 17330 18706 12462 18799 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis 12369 69719 21973 97165 434174 14939 13804 12367 13347 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway 16416 16399 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA 14688 18749 19088 14699 271639 18747 19085 19087 19084 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 85305 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway 14381 72157 19895 71336 74419 21351 66646 232449 56421 19139 14751 14121 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome 110006 22239 15275 14751 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway 230558 12279 15139 12266 12274 109828 625018 12259 12260 12262 667277 317677 12263 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis 12183 21991 100043349 14377 13806 230163 56012 319625 20526 14751 18746 18648 18642 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism 20322 15275 11674 18640 14121 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway 20927 16334 12286 20526 56808 12295 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism 110006 22239 15275 14751 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism 192185 67375 78914 226518 18113 225994 12182 59027 67993 76952 11761 18605 18950 18115 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway 11421 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism 20322 15275 18640 14751 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL 17869 56717 18671 14784 22059 20662 20850 16452 20517 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism 12359 107766 70560 56720 98256 71562 22375 21990 11298 70789 266645 13195 21743 13076 23923 15930 11669 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation 17436 104112 66945 66925 56421 17449 67680 66052 12675 12475 12974 117149 17087 21898 22034 13358 18033 17874 18035 16151 16150 19697 107476 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis 14701 14688 14309 210044 18749 14699 12000 COAGULATION%SMPDB%SMP0000586 Coagulation 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation 68738 12359 60525 72535 11669 13106 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 353172 27050 27370 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia 11677 72157 74246 14430 226413 216558 12091 14387 11605 15275 14377 14595 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) 66234 235293 18194 98386 13121 13360 15490 13595 74754 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) 192185 226518 93759 59027 66454 12494 71361 18104 74080 22059 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer 55951 216456 20540 209837 56309 16828 17436 269951 55963 104112 20514 66945 18563 14719 67834 56451 66925 20501 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 67680 66052 12974 14661 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis 19895 21991 66646 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle 11931 20495 11932 56365 11933 100038824 11928 98660 232975 107723 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway 11944 11945 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency 21823 18948 13195 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway 14688 19229 12927 18705 18803 20315 12767 14677 14699 26413 110157 15461 18033 18035 12928 26395 26417 19303 14682 14083 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway 11421 FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway 11607 100038824 11606 11421 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway 20266 11931 15550 11932 11549 107141 17161 109731 18549 11933 20264 11928 98660 13113 56808 12295 56448 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary 18642 14120 21991 15275 230163 11676 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 13077 13114 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia 76282 11611 55951 18563 224805 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling 19766 21353 12366 26397 12905 71609 22030 21926 26412 100040260 26399 26419 26398 12675 26416 26401 16476 18033 26400 18035 16151 16150 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation 16922 11671 26874 11666 26458 56794 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway 18750 18795 18803 11651 104709 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 15107 52538 93747 231086 97212 11363 14081 57279 12894 12896 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 76500 228550 71207 69718 327655 16329 71780 55980 269180 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis 18563 55951 12183 21991 100043349 14377 13806 230163 56012 319625 20526 67863 14751 14121 211347 18648 72157 18534 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13087 11928 394433 13088 98660 394434 110834 56808 12295 14262 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism 14317 11670 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 105148 27370 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle 14719 78830 17448 67863 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway 238505 108645 74129 110695 232087 14711 20425 12116 192166 218865 108037 68682 100434 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway 109828 625018 12263 230558 17195 12279 17175 15139 12266 12274 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis 14104 107476 CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway 434203 104158 72269 72962 22171 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine 20115 104458 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism 14415 268860 104776 11669 64705 99586 11754 103149 338403 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway 17523 13114 21973 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria 17449 17436 104112 55951 18563 68263 67863 18597 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway 107141 18979 70839 13077 13114 13088 18671 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway 20927 16334 12286 20526 56808 12295 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway 20648 11931 11932 11549 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) 15108 52538 93747 26922 231086 97212 19063 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells 18750 16331 18803 14125 16822 16163 16191 16189 16653 20963 19353 228026 18783 14784 18706 17096 18176 16797 12981 14127 57257 26419 14126 26398 110157 26416 15461 11651 18708 26400 14360 26395 26396 26397 26413 12229 21926 26399 20662 14389 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production 20608 12346 15466 11944 11945 20604 14459 12426 12671 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 216456 269951 66945 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 14661 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway 74419 66171 56421 14121 14751 14381 110639 19895 72157 71336 21351 66646 232449 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation 18127 18750 18795 12912 18033 26413 16151 16150 26417 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway 13649 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form 69019 110948 100705 26363 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway 11944 11945 NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism 71522 14415 211488 246277 12583 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway 238871 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway 13649 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway 70839 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation 19645 15469 27221 18049 15417 12226 14164 12227 12443 22059 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway 20927 16334 12286 20526 56808 12295 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium 63873 60613 226922 26946 60596 16536 110862 271639 54195 18127 234889 19091 19092 22065 22066 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway 107141 13077 13114 56448 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway 13178 13026 20887 18102 50773 26357 20519 212862 18671 17250 66588 76408 20517 12780 18655 68671 20518 239273 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway 107141 20538 13114 56448 15567 18671 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) 72157 74246 67883 14430 216558 22235 103988 14635 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway 72303 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway 11944 11945 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency 110006 22239 15275 14751 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification 18950 11832 64008 14873 57344 20528 20525 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation 14688 18795 18751 18033 16438 15465 14702 14682 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism 228550 327655 16329 71780 55980 234515 217837 17330 56409 27399 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20226 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling 14688 18795 11651 19877 432530 20807 16438 53978 14702 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway 20186 14170 83379 14186 14183 14184 20494 14182 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell 20648 20927 20271 14526 20650 12286 20526 56808 20649 12295 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 14688 210044 18749 19222 14699 17897 107589 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 26940 81897 53791 21899 66724 21897 170744 26409 26419 26398 12675 12475 117149 26416 17087 26401 21898 22034 18033 17874 18035 16151 16150 19697 54473 170743 16179 66513 142980 24088 68652 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis 18605 22361 71743 106564 75735 66812 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway 100038824 11606 11421 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 14688 18479 109905 11909 19094 18706 26407 18034 54126 109880 26419 11540 12675 223864 13712 56513 15461 76089 11651 26401 16476 18762 18033 26400 18035 16150 26396 18607 18749 12912 14699 26413 20111 26399 12015 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor 18750 18795 16438 14682 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria 15108 52538 93747 26922 231086 97212 19063 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 110960 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect 55951 100043349 13806 56012 18655 20512 18770 66945 67834 66925 56451 209692 20501 11429 14194 13382 235339 21881 68263 170718 15926 11428 78920 14751 14381 17449 18641 18746 67680 66052 12974 19895 14661 14660 15277 21351 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis 110391 20751 13361 11677 12408 19286 320415 14528 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism 72157 74246 67883 14430 216558 22235 103988 14635 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine 20115 319195 67248 100043391 100040331 432502 667279 668144 100043755 621100 665189 67281 666899 100042670 629957 100039316 76846 667739 234734 100038875 19921 100038991 267019 100043876 100043000 100043423 16785 100042986 20044 100040298 20088 100042740 56040 667618 57294 666669 100040970 20085 20084 19899 67891 66480 67097 19934 66481 67025 100039924 19941 100042823 14694 100039656 20055 672959 20054 666586 676253 67427 670211 100043527 27207 666487 68193 67186 19989 19951 76808 75617 20103 20102 20068 22121 65019 26961 27050 27370 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway 224814 76408 12575 12780 13114 18671 17250 545486 19765 22143 22059 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway 11421 CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway 20648 11931 11932 11549 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway 100038824 11606 11421 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism 69718 102954 16332 277360 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis 12850 71883 217707 52064 230027 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia 14317 11670 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway 107141 13114 238871 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 15107 52538 93747 231086 97212 117147 57279 11364 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism 58250 54200 20887 23827 211389 23972 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism 110115 15483 71853 69191 67838 12304 78925 208665 394436 15487 83702 19035 64136 13075 12282 67397 14828 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway 11670 107141 11668 14863 13114 13088 13087 72303 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate 55951 269951 112407 112406 66945 18563 67834 27376 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway 16542 22339 14254 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway 22236 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 71773 231396 18390 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13077 13114 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis 12660 19210 68671 320951 99712 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine 20115 319195 67248 107271 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism 224020 103199 228550 56208 18711 225326 16329 71780 55980 228361 66461 72469 56727 217837 75678 234729 269180 75669 17330 18706 69718 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis 71519 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway 15108 22236 231086 97212 13088 13087 66885 117147 74147 56357 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 226414 27050 27370 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance 20537 11931 11932 11933 11928 226413 98660 20526 232975 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway 100038824 11606 11421 METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 20648 20271 20650 20649 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway 224814 11668 13114 13088 56448 394434 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway 13867 18750 11491 19164 13649 100042150 13869 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway 18479 19353 76932 329251 12443 19765 18595 18538 12568 12631 57257 11461 12575 12445 17906 16885 12331 26401 18805 83767 107589 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism 13142 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation 107869 12411 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 22239 15275 14751 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway 55984 14082 26409 12675 26401 21898 22034 18033 17874 18035 16151 16150 19697 22190 19766 71609 21926 53859 16177 21937 21938 16179 17979 66513 16175 207565 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism 11461 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13114 11928 13088 98660 13113 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 72303 16508 18390 232975 14811 14810 13488 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect 55951 100043349 13806 56012 66171 18655 20514 67834 18563 56451 20501 20917 11429 13382 14194 18293 230163 20526 27402 68263 21881 170718 15926 18597 11428 78920 14751 15929 17449 14381 18641 18746 67680 66052 12974 14661 19895 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism 83603 68801 56473 76267 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism 238505 110695 232087 18618 12116 269378 218865 108645 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency 69019 110948 100705 26363 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway 100038824 11606 11421 ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine 20115 319195 67248 100043391 27267 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency 76282 11611 55951 18563 224805 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway 13649 FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway 100042069 104158 12780 13114 436059 26357 18671 394434 72303 23917 28253 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway 107141 18979 70839 13077 13114 13088 18671 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis 99439 224480 21819 114479 22018 13058 50490 13057 214593 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation 234730 75454 22122 75540 21991 230163 54128 76355 320844 14121 18641 20322 16548 11677 18639 110119 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 14688 18479 109905 11909 19094 18706 26407 18034 11541 54126 109880 26419 12675 223864 13712 56513 15461 76089 11651 26401 16476 18762 18033 26400 18035 16150 26396 210044 18607 18749 12912 14699 26413 20111 26399 12015 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell 20927 12286 20604 20526 56808 12295 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling 384783 56717 16337 16367 16334 64930 22084 13685 13684 11651 30955 104709 20539 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency 110446 71911 15356 67041 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling 15251 16176 21898 64384 216799 320452 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway 13114 394434 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway 11421 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 18387 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 14688 18749 19045 12912 14699 15562 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism 71853 69191 12846 67838 12304 394436 19035 15485 64136 12282 13076 67397 14828 20860 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway 13649 NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway 18750 18795 13649 18751 18747 14784 26419 110157 13712 26416 15461 60595 26401 16476 18805 14714 14715 14672 432530 26400 12288 17390 26395 26405 12322 17387 14308 16866 56808 20779 12295 11911 13653 12640 15200 12289 54652 12292 26397 26413 20662 16438 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway 22171 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism 228550 83493 56208 225326 71780 228361 55980 66461 217837 56727 75678 269180 234729 23827 75669 17330 12462 170835 69718 18799 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 26940 81897 26409 26419 14281 26398 12675 12475 117149 13712 26416 17087 26401 16476 21898 22034 18033 17874 18035 16151 19013 16150 19106 19697 26397 26399 54473 170743 16179 66513 142980 24088 68652 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis 110911 66586 52123 66461 14732 74451 14555 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway 18750 18803 18751 19353 16818 14784 18706 16797 20416 26419 26398 14281 110157 13712 15461 26401 16476 18708 18033 18035 14360 26395 19055 12501 19697 26417 22637 320139 19419 22190 12502 12503 19056 12500 18021 73181 18018 18019 20662 19057 640703 22324 30955 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway 63959 229363 13340 269346 22017 15452 11534 231327 11761 19353 23917 22436 27416 239273 114304 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway 12288 56808 12295 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway 18750 640703 18749 18125 11669 16438 22436 19055 14811 14810 13385 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect 55951 229699 74419 100043349 13806 56012 20525 66171 18655 66945 18563 67834 56451 66925 209692 20917 15275 14194 13382 235339 68263 15926 56421 18597 11428 78920 14751 14381 17449 18746 67680 66052 12974 19895 14661 14660 21351 110208 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia 57028 216134 11647 103711 11761 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome 18718 224020 103199 18795 16331 13649 56208 52858 18711 18704 225326 13866 18707 18720 228361 234515 234729 75669 18708 19211 64436 104015 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic 107869 14630 14718 14629 12583 83429 27267 246221 16828 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) 20186 28250 239273 227289 20494 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids 16922 26874 14081 57279 11666 11669 12908 56794 12896 72129 56273 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway 22171 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway 13114 13088 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 72303 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production 14688 17200 18749 14699 18976 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 22239 15275 14751 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway 11670 11668 13114 13088 13087 72303 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway 11944 11945 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway 18750 18749 18125 12313 19055 14811 14810 13385 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway 11863 11622 15519 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway 18750 18803 18751 20807 20848 14784 100039026 20416 13645 20850 26419 218397 16452 14281 110157 13712 15461 16476 26401 26400 26395 26417 13869 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling 14688 67168 11651 19877 432530 20807 14702 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease 110006 22239 15275 14751 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway 107141 13077 13114 56448 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway 13113 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation 18642 14120 21991 15275 230163 11676 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 15115 27050 27370 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway 20538 56448 15567 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin 14688 12640 210044 18749 19045 16867 12912 14699 16866 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation 20537 11931 11932 11933 11928 226413 98660 20526 232975 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation 18746 21991 100043349 56421 14751 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis 14245 13350 14732 55979 14555 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency 107869 12411 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway 11944 11945 VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia 14415 268860 104776 11669 64705 99586 11754 103149 338403 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation 237320 209692 13382 266645 78920 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 22375 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism 228550 327655 16329 71780 55980 234515 217837 75678 269180 17330 56409 27399 69718 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule 11931 11932 20497 11933 11928 194352 98660 11827 56365 100038824 11828 20541 11944 11945 232975 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway 11421 PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells 18750 16331 18803 14125 16163 16189 20963 16653 19353 17060 16818 14784 18176 17096 16797 12981 26419 14126 110157 15461 11651 18708 26400 14360 26395 26396 26413 21926 14389 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation 18750 18795 12912 84112 26413 19094 18127 12675 19224 18033 16151 16150 26417 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway 670717 18646 330914 11545 11855 11857 12370 12362 12367 11783 12371 16476 14939 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria 18642 14120 21991 15275 230163 11676 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 70223 65019 27050 27370 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine 14688 210044 18749 19045 12912 14699 15466 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling 14688 18795 11651 432530 16438 14702 65086 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate 269951 66945 55951 18563 67834 56451 66925 209692 20917 11429 216456 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) PMC5869700__F6 Toll-like receptor signaling pathway 3569 7096 7097 5879 10333 4615 114609 4792 8772 3929 958 10454 23118 51135 3654 4609 85451 7100 1513 6772 7189 6955 PMC4730296__F1 Outline of melatonin biosynthesis and function 15 4199 9575 PMC5085738__F4 Schematic model of drought responsive proteins involved in photosynthesis, carbon metabolism, fatty acid metabolism, and nitrogen and amino acid metabolism 7086 2597 275 5091 3250 4841 189 6120 1431 4397 PMC6414715__F10 Activation of antiviral pathways in Atlantic cod 3458 3460 3717 7098 51284 54106 10010 57162 7187 51135 7189 8772 23118 257397 3665 3661 4792 4790 4615 PMC7914425__F5 NOD-like receptor-signaling pathway constructed based on full-length sequencing and annotation results of the skin transcriptome of a sperm whale 64127 57506 3661 3665 PMC6955855__F5 Terpene and terpenoids biosynthesis 4598 3652 3422 91734 PMC8197487__F7 Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review 4803 10392 3550 64127 2444 64170 8195 3725 572 581 7189 5728 7018 2308 126669 PMC6204425__F3 Some regulator genes in the eu-/pheomelanin synthesis metabolism 5443 51151 4948 8455 3815 7018 4286 5077 434 9365 1638 PMC6370674__F2 Pathway map of Notch signaling (A) and Th1 differentiation (B) in KEGG 7054 920 4279 43 6418 1191 3717 6775 PMC3760627__F2 Diving adaptations in the Chinese alligator genome 3039 6420 6723 3043 2720 2799 2687 9791 51703 35 81490 3030 9453 2686 4716 4047 4711 717 6611 5169 56474 PMC7012612__F4 IGF1 signaling pathway is under increased evolutionary constraint in long-lived, large-bodied mammals 6010 5781 3479 3480 5590 6464 3265 3667 8660 5747 1398 9564 5894 5266 5829 2885 6654 5170 5587 1399 5580 8440 5770 6714 2887 7531 5879 572 7534 PMC8490651__F6 Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19 1636 4734 4513 PMC9021737__F5 De Novo Assembly of 20 Chicken Genomes Reveals the Undetectable Phenomenon for Thousands of Core Genes on Microchromosomes and Subtelomeric Regions 7157 8570 27044 629 5518 6850 695 558 10628 56658 602 58509 7186 5971 7187 10075 26525 2316 1191 PMC9611604__F7 How does Quorum Sensing of Intestinal Bacteria Affect Our Health and Mental Status? 196 1499 1543 405 3458 PMC4588145__F1 Fish nucleic acid PRR signaling pathways 54106 7098 51311 51284 51428 4615 29110 3665 3661 PMC3402511__F4 Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain 5728 2308 5170 3630 3479 3643 207 5163 5164 7249 7248 102466864 2475 PMC6279911__F1 MiRNA targets in teleost fish immune system 7297 4615 6772 6773 10379 3661 3665 57506 PMC8236053__F2 Comparative Review of the Cell Biology, Biochemistry, and Genetics of Lactose Synthesis 360 2683 1611 3906 5236 7360 2582 51083 PMC6170637__F4 Animal and plant cells 10392 64127 6187 58484 114548 PMC9146692__F3 Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models 7098 51311 51284 6772 6773 PMC5725996__F1 Summary diagram of energy metabolism pathway 2821 226 5214 5236 2203 2026 5313 5105 5091 1431 3939 197257 4731 4704 4540 4705 50617 4509 64077 4967 PMC8676434__F4 Evolution of regulated cell death pathways in animals and their evasion by pathogens 581 8772 331 8717 8737 PMC9482985__F2 Transcriptional regulation of oil biosynthesis in seed plants: Current understanding, applications, and perspectives 51586 2023 52 8694 PMC3195753__F3 Comparative analysis of plastid transcriptomes in cucumber 6201 6202 6205 6209 6222 6223 9045 6146 25873 8192 4145 4553 266710 4519 5091 PMC5983613__F5 Leptin is a very important factor that links fatty acid Beta-oxidation with oocytes maturation 8027 34 35 5292 3032 1376 3295 3033 9213 1892 PMC7937231__F10 Bacterial invasion of epithelial cells pathway (KEGG ID: hsa05100) in the CoNS vs 867 1213 858 1398 3611 391 8976 387 10093 7414 PMC7937231__F8 Bacterial invasion of epithelial cells pathway (KEGG ID:hsa05100) in the CoPS vs 867 1785 1211 1398 3611 8976 387 7414 PMC8034193__F4 Calcium (or Ca2+) signaling pathway in T 90550 5350 291 858 3270 805 10345 887 613 5266 PMC8371935__F1 Phylogenetic Analysis of Core Melanin Synthesis Genes Provides Novel Insights Into the Molecular Basis of Albinism in Fish 4157 4286 7306 6490 PMC3238295__F5 Bridged pairs and shared edges between 2ROs in the apoptosis pathway 598 596 572 665 8739 664 836 90427 637 638 840 790 842 4671 100271849 10887 331 841 843 8772 581 834 PMC5301350__F7 Differentially expressed genes (DEGs) in photosynthesis pathway in different combinations 4519 5091 6670 6671 PMC5536018__F4 The alternative splicing and immune function of RLRs-mediated signaling pathways in response to viral infection in teleost fish 57506 7187 3665 3661 PMC6357155__F2 The life cycle of SARS-CoV and MERS-CoV in host cells 59272 1803 5478 PMC7117992__F2 Key longevity-regulating pathway proteins whose functions may be altered or enhanced by differential PTMs/proteoforms in long-lived species 847 3643 9474 9776 2475 7248 7249 23411 51548 142 PMC7214760__F1 Biosynthetic pathway of aromatic amino acids 85569 4548 367 PMC7431475__F11 Additional examples on TA-based MECs 6608 847 4311 PMC7432306__F4 Reconstructed metabolic map of xanthan biosynthesis in Xpm 5185 10450 6120 1896 5480 PMC8618018__F2 Morphophysiological and Proteomic Responses on Plants of Irradiation with Electromagnetic Waves 64326 1642 5091 2232 4508 PMC9316979__F7 Transcriptome Analysis Reveals Key Gene Expression Changes in Blue Catfish Sperm in Response to Cryopreservation 7124 3466 1616 8772 9049 3014 10379 7098 572 637 27005 4060 1540 828 81030 11035 836 835 197259 5008 790 114548 4015 3606 472 9118 1431 PMC3547545__F1 An illustration of the IIF pathway genes.Notes: Arrows indicate the direction of signal transduction 3630 3485 3489 3488 3486 3484 3487 3643 8503 5295 5296 5291 5290 5166 5163 5165 5164 207 208 10000 2152 PMC6237963__F6 Cell cycle regulation pathway and the genes whose expressions were altered by 11-KT 1874 9126 10735 10274 5885 4087 4088 4193 4089 5934 6502 324 991 9184 5111 699 993 995 994 9134 894 1021 1019 8900 85417 9133 891 1022 7316 983 5347 999 990 8318 1869 23595 4661 8317 10926 PMC6365411__F1 A) Experimental design depicting the sampling time points represented as days post hatching (dph) during the different gonad developmental stages covered by the study 5212 5950 64220 1381 8854 220 PMC6895189__F4 Adaptive divergence of Notch signalling pathway in tiger 3714 10683 6868 1387 3955 9253 1856 4242 23385 1857 55851 9612 23220 5664 1487 780904 8650 55534 22938 113878 3280 171558 182 5663 1488 PMC6911977__F5 Metabolic pathway for 2,3-butanediol production in yeast (modified, based on S 2819 2820 622 127 PMC7924645__F2 MSH biosynthesis and regulation in actinomycetes 3630 4397 4548 PMC7990044__F3 Genetic modifications designed to address xenograft injury mechanisms 51083 324 961 140885 3133 PMC8461181__F3 GnIH in Biological Rhythms and Social Behaviors 9575 1499 5337 PMC2330246__F1 Overview of NAD biosynthesis and salvage pathways and a link with other metabolic pathways via ADP-ribose 6120 7086 5640 PMC2702319__F4 Distributions of the orthologous gene groups containing duplicate genes that arose through 3R-WGD (shown as gray boxes) in the network diagrams 814 1431 47 171425 2271 4967 1743 1738 PMC2702500__F1 Metabolic reconstruction of Db 3939 51430 367 717 2271 6955 PMC2724271__F4 Metabolic map of HIF-target genes 2997 790 5033 8974 2271 2597 3939 5230 230 4282 51400 7416 54205 54968 8659 23479 10061 51073 26355 664 81894 6183 2520 1356 5743 2235 7422 5338 5710 9044 3516 5211 9344 226 2023 4863 7939 7052 301 8453 7037 7431 1509 5914 2908 3099 3416 3880 5209 901 3481 3689 4267 3837 7514 5905 4771 7852 7015 4869 7167 7043 2821 5154 5054 4313 117247 2019 3485 9138 7018 3486 3098 5223 5329 PMC3584916__F3 Signaling pathway of IFIT family genes 7099 4615 7098 54106 3665 3661 PMC3847144__F1 Isoprenoid and amino acid biosynthetic pathways 4598 9961 3652 PMC5578024__F8 Differentially expressed genes associated with the cell cycle were annotated by KEGG 9126 4089 4193 6502 699 5111 993 1017 1022 999 4661 1874 1869 10926 4999 PMC6406535__F1 Contrasting Patterns of Rapid Molecular Evolution within the p53 Network across Mammal and Sauropsid Lineages 595 1026 2810 894 898 472 51512 841 11200 355 637 545 1111 581 842 4193 836 4194 6477 64065 64393 3486 3479 7249 5728 5054 143686 55240 25898 900 8493 51548 1432 PMC6760925__F5 Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations 15 4544 2548 8473 1636 438 PMC8445033__F1 Convergent Loss of the Necroptosis Pathway in Disparate Mammalian Lineages Shapes Viruses Countermeasures 8737 11035 197259 81030 PMC8810313__F1 Viral deubiquitinases and innate antiviral immune response in livestock and poultry 5355 57506 7189 7187 115004 3661 3665 29110 9636 PMC8841753__F2 Peptide-Based Vaccines for Tuberculosis 7097 7096 10333 4615 3569 6347 PMC9553197__F2 Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective 355 581 5728 999 5879 2475 1956 836 842 4313 4312 4318 PMC2886068__F2 Bile salt synthetic pathways 1581 80270 1593 PMC3268129__F1 Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins 150465 5979 10750 PMC3368902__F1 Postprandial Regulation of Hepatic MicroRNAs Predicted to Target the Insulin Pathway in Rainbow Trout 3667 8660 5728 2475 PMC3584916__F4 Antiviral and immune regulated function of IFIT family genes 1999 57506 3437 3433 3434 29110 581 3661 24138 PMC4064697__F2 Schematic summary of the photoneuroendocrine control of food intake and body weight 7252 7253 1734 1735 5914 1382 PMC4092924__F3 Proposed model of IFNT signal transduction cascades that is independent of STAT1 in the ovine uterine LE and sGE 203 5595 5163 2475 6194 1471 3977 3660 3659 PMC4668848__F2 Influence of MAP on TLR9 signaling 54106 4615 7187 51135 3654 7189 3656 8772 3661 6714 5058 PMC5377455__F7 Proteomic signature of muscle fibre hyperplasia in response to faba bean intake in grass carp 1376 5901 95 PMC5923480__F2 Feline restriction factors and FIV counteraction mechanisms 7852 10955 25939 PMC5954090__F7 The metabolic characteristics of a low-carnitine zebrafish model 4023 3643 2475 PMC6156122__F2 Pathways to retinal regeneration 1499 6496 429 27040 PMC6190877__F1 General schematic diagram of molecular players involved in sex differentiation of gonochoristic teleost with genetic sex determination 1761 268 6662 1588 668 399823 PMC6236061__F1 PPAR signaling pathway 5465 2168 4023 2170 51 9370 PMC6400144__F2 Regulation of the C-type lectin receptor signalling pathway by curdlan and MacroGard® 10487 6773 602 1540 3569 3562 6850 7054 5971 246778 6347 4193 PMC6610330__F4 Model illustrating potential effects of cold stress on membrane lipid pathway in peanut 283871 5053 4018 5091 PMC7025585__F1 Bat cells mount an antiviral response to RNA viruses, but limit the expression of inflammatory cytokines 23586 57506 51284 6773 3661 7124 114548 PMC7571161__F4 IFN signaling and synthesis pathway 7297 23586 59272 57506 3661 7098 10379 6773 3455 PMC7912633__F2 Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets in the canonical pathway (adapted from [,,,,,,]) 613 5970 4513 2876 1401 4504 PMC7943466__F4 General mechanism of MP formation, its mode of action, and the proposed possible impacts of diets on MPs that could be linked with CSVD 107966124 6010 7018 7412 5091 PMC9616467__F8 Embryonic transcriptome unravels mechanisms and pathways underlying embryonic development with respect to muscle growth, egg production, and plumage formation in native and broiler chickens 2060 2059 1956 23118 2888 6655 4893 5605 31 8200 2194 10763 4087 64750 3485 3484 32 51778 5467 6885 4920 4593 2308 9133 85417 896 899 858 859 3479 3481 5139 5144 1158 207 208 2475 8848 9819 388 387 389 54509 23433 1978 5565 51422 2645 2821 229 2597 2023 3945 PMC2678157__F9 The steroid synthesis pathway showing genes regulated in this study 6770 80270 3293 3291 PMC3362997__F10 Competitive displacement of DMP1 by ASARM peptide modulates PHEX–DMP1-mediated FGF23 expression (see central osteoblast in green) 8074 1758 5251 10312 56955 PMC3618895__F4 Significantly changing expression sub-networks in LMB hypothalamus 5443 7040 2688 5617 1813 1588 4852 1812 2798 847 9456 335 7054 5816 2571 5106 5624 2100 2033 6558 23600 2353 9066 367 4792 29843 3818 3845 PMC4018400__F4 De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response 7099 7096 7097 7100 51284 51311 4615 54106 7098 51135 7189 7187 8772 23118 10454 29110 3661 PMC4018400__F5 De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response 1493 4179 3932 867 2534 952 27040 3702 2885 717 1019 8915 29851 940 5163 PMC4177847__F4 Comparative Transcriptome Analysis Reveals the Genetic Basis of Skin Color Variation in Common Carp 81029 434 6425 4157 2263 4286 1638 7306 PMC4425321__F1 General scheme, illustrating BDNF-TrkB signaling through three main pathways in the neuronal cell (NC).Notes: PLCG pathway results in activation of neuronal plasticity and long-term memory formation via PKC, TRPC, and transcriptional factor CREB 627 2885 5163 2475 581 PMC4524600__F5 Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish 1436 4254 7097 7099 5879 6850 613 930 11140 5728 PMC5159197__F1 IgA Nephropathy Enigma 56913 51083 652070 23152 PMC5896114__F4 Location of si:ch211-167b20.8, socs9, eif4e1c and CALML6 in the insulin signaling pathway 867 355 2308 3643 3630 7249 6009 572 2475 2000 2885 2002 PMC5913290__F1 Key elements in the DNA damage response (DDR) pathway 6741 472 545 PMC6167544__F8 Cellar signal transduction pathway induced by GALT 351 2592 51135 4615 3654 3656 7189 3553 PMC6277881__F4 Subolesin/Akirin function in immune response pathways 7124 23118 55122 PMC6770051__F5 miRNA-responsive biological pathways and the presence or absence of interactions between its genes and the transfected miRNA 6396 10956 7353 100506742 22926 7327 9978 8454 6500 406 9575 3397 9732 6010 64411 998 7410 367 1398 790 10636 5310 2695 27040 90070 258010 83939 759 7316 PMC6881465__F1 Animal cell cytokinesis 5347 9055 1894 387 PMC7025585__F2 Exogenous and self-DNA sensing pathways are dampened in bat cells 4332 9208 9447 54106 6773 23586 114548 PMC7177938__F4 Gene-Ontology (GO) term enrichment and pathway term network analysis of DEGs shared by ADJ versus PRE and ATT versus PRE lists (1928 DEPs) 3240 6010 5426 5624 759 PMC7298530__F2 Unique Energy-Saving Strategy during Hibernation Revealed by Multi-Omics Analysis in the Chinese Alligator 7200 6262 7253 7038 4958 63923 1854 2548 4668 23237 1497 4353 1520 4689 PMC8012063__F4 Status-dependent regulation of Kyoto Encyclopedia of Genes and Genomes pathway hsa050160 Alzheimer’s disease at the cross-tissue level 351 671 23385 3416 4023 348 572 842 836 8772 637 317 6622 100506742 22926 7124 2932 840 3064 4478 25942 5978 627 3092 6908 140805 6667 6874 836 25886 6648 7350 PMC8397452__F6 Multifaceted Roles of Proline in Cell Behavior 5625 999 91461 54407 4553 5640 4087 468 10637 7044 2250 2253 PMC9052532__F3 Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies 367 4860 3595 3458 7054 PMC9200072__F4 Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids 6770 6822 8644 PMC9367564__F1 Versatile Triad Alliance: Bile Acid, Taurine and Microbiota 2264 1581 1582 5697 PMC9479325__F5 Integrated analysis of immune parameters, miRNA-mRNA interaction, and immune genes expression in the liver of rainbow trout following infectious hematopoietic necrosis virus infection 10010 1654 3661 8767 79132 30835 4615 PMC9547585__F7 The let-7f-5p regulates the PI3K/AKT/COX2 signaling pathway in forest musk deer lung fibroblast cell 4513 5163 5290 4593 PMC2147077__F4 A High Quality Draft Consensus Sequence of the Genome of a Heterozygous Grapevine Variety 2271 26136 3652 3422 PMC2827416__F6 Impact of high dietary protein on lipid metabolism in porcine adipose tissue at body weight 100 kg 4023 355 7038 PMC2845723__F2 The bile salt synthetic pathway 1581 80270 1593 PMC2947987__F3 Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions 6101 3929 1208 4482 465 4312 PMC3539953__F5 Representation of the “Interferon Signaling” and “Toll-like Receptor Signaling” pathways 8554 581 3437 100187907 114609 4615 54472 2002 PMC3659299__F4 Scheme depicting the current knowledge on PAC1-mediated signaling cascades resulting in a variety of neuronal outcomes 4803 6714 55872 85451 PMC3744227__F1 Chemopreventive potential of natural compounds in head and neck cancer 1950 1956 5970 2932 4193 2475 1499 PMC4013251__F1 Canonical microRNA (miRNA) biogenesis pathway: miRNAs are initially transcribed as long, variable-length hairpin RNA substrates called primary miRNAs (pri-miRNAs) directly off the DNA template in the nucleus by RNA polymerase II (A) 29102 54487 27161 PMC4092924__F2 Schematic illustration of the current working hypothesis on IFNT signaling in ovine uterine stroma and uterine glandular epithelium compared to uterine luminal (LE) and supferficial glandular (sGE) epithelia 7297 203 6773 6772 9636 567 3627 2634 3659 1471 3484 3977 6513 115584 6542 3660 PMC4244643__F1 Biosynthesis of Isoprenoid building blocks 4598 91734 3422 PMC4276719__F10 Fatty acid metabolism in bacteria 27349 10157 8772 PMC4425321__F2 Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness 627 7189 998 PMC4474670__F6 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity 5900 6667 6010 790 10636 50966 27040 PMC4474670__F7 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity 4504 28960 22894 1656 80153 23644 54464 22803 6104 4035 115752 1233 4849 4850 4848 9125 51691 25804 57819 27258 5073 27257 9924 255967 367 23632 PMC4524600__F6 Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish 3814 1241 2862 799 5021 6752 2925 2690 5618 624 PMC4647707__F4 Differentially expressed genes in the cytokine-cytokine receptor interaction pathway (ko04060) 7124 3562 1235 3624 3625 83729 10803 6370 5008 3791 1233 2324 6366 1236 3977 3558 6347 3815 3572 659 2322 1271 6351 4049 3565 650 4055 3581 3578 56832 355 6368 7536 3952 59067 1232 53832 85480 50604 11009 2057 2056 1896 3559 10913 2690 2689 5617 5618 149233 4352 55801 PMC5281639__F1 Induction of interferons (IFNs) and establishment of an antiviral state in a model chicken cell 7098 7297 3550 29110 57506 3665 1386 3725 5548 6772 6773 PMC5587470__F7 Diagram of muscle‐growth signaling pathway and differentially expressed genes, thus summarizing the effect of thermal gradient on muscle growth 3481 3479 3480 4205 2475 PMC6020732__F2 AhR in breast cancer and the role of dietary compounds 6999 672 5053 196 1545 4513 PMC6021495__F10 Working model proposed for the synergistic action of GH and insulin on IGF-I and -II expression in the carp liver 2690 3643 3717 2475 PMC6791490__F3 Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches 7173 6957 7200 7201 7054 7253 196 PMC7027041__F8 Signaling pathways under heat stress affecting bGCs functions: A network map of pathways significantly (P < 0.05) enriched after heat stress 5564 5347 6648 23600 56475 2690 901 7249 3265 54331 2309 4791 4802 894 7186 8625 847 3320 6237 836 1514 7184 3326 581 22808 6722 3065 2353 2937 3329 5881 759 2936 55741 2940 6138 6175 23659 54546 5111 285362 6205 219927 10134 10808 9553 1583 29088 2581 949 6770 6150 79158 6229 6231 64979 PMC7057487__F3 Conceptualized network for the 7 enriched neurotransmission pathways 775 776 115 2776 2782 2890 57084 2891 3710 9229 2894 2898 2899 6505 5594 5515 5602 5601 673 6323 2932 781 847 6529 6332 5334 493 3786 2571 PMC7057487__F4 Interactive network for the 8 enriched signaling transduction pathways 145957 3815 2260 10319 2932 5336 673 5649 3688 56034 2782 5515 3480 7249 672 3680 7058 3674 399694 9542 3918 847 2885 775 491 2737 2890 7074 4763 134 115 776 5602 8399 4158 1387 1910 8398 5594 8310 490 1260 30814 50487 2891 7416 3710 91807 999 57551 4775 5590 3778 6788 889 5593 781 3552 1848 5801 PMC7260202__F5 Crosstalk between androgen and Wnt/Beta-catenin leads to changes of wool density in FGF5-knockout sheep 1499 367 2250 51176 6469 22943 PMC7359717__F1 Synthesis and release of ACh by tuft cells 346562 1103 5330 29850 590 43 PMC7396149__F4 Immunosuppressive drugs for corneal transplantation and their sites of action in the immune system 1493 941 940 958 1431 324 2475 PMC7912808__F6 Ingenuity pathway analysis of processes related to Barrett’s transcriptome 6690 6927 57650 1050 3172 6597 7099 638 6010 PMC8080601__F3 Processing, extracellular regulation, and signaling mechanisms of GDF11 and MSTN 10220 649 4089 4086 4090 4093 4087 4088 92 10272 4054 PMC8231932__F4 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art 83939 468 355 637 8772 596 581 7494 22926 PMC8775565__F6 Physiological implications and importance of both simple-type and composite-type GSKIP in Wnt signaling 51527 474168 1499 PMC8940980__F1 SARS-CoV-2 Infection: Host Response, Immunity, and Therapeutic Targets 7113 114548 834 4615 59272 3569 PMC8954241__F4 Toxic Mechanism and Biological Detoxification of Fumonisins 8717 7124 8772 355 8678 581 9474 10533 2475 PMC9069556__F2 Coronavirus Infection and Cholesterol Metabolism 1717 1718 10682 9023 59272 7038 PMC9841179__F4 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases 10524 54778 10475 81844 57337 8841 9097 1191 115004 10419 284076 9654 983 22954 79102 79594 6850 55593 29110 10206 6048 5770 5771 23650 5494 8408 5537 PMC9841179__F5 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases 115004 10533 23440 29110 3661 PMC2788021__F3 A model for torpor induction in mammals that links reduced availability of food in the environment with the energy status of the cell, the mammalian circadian clock, and response to oxidative stress 10135 23411 9575 PMC2820251__F1 Innate immune evasion strategies of influenza viruses 57506 7189 7706 29110 7187 10010 3661 PMC2873055__F9 ACBD3-mediated signaling pathway and cellular regulation 5573 706 64746 8650 PMC2885424__F7 Transcriptional Regulation of the IGF Signaling Pathway by Amino Acids and Insulin-Like Growth Factors during Myogenesis in Atlantic Salmon 3480 3667 8491 2475 3489 PMC3039968__F2 Regulatory Processes Linked to PL Metabolism 95 4513 4512 717 5228 5226 PMC3185594__F8 Signaling pathways involved in JSRV Env-induced cell transformation 7099 8692 6714 5879 6009 2475 PMC3707916__F5 Altered Protein Networks and Cellular Pathways in Severe West Nile Disease in Mice 1759 26999 5702 3146 7124 4684 814 351 836 581 596 4133 1809 1808 2596 PMC4269174__F4 Complementary metabolic pathways between the brown planthopper and its yeast-like symbiont 8039 5624 7011 4810 PMC4795702__F2 Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I 7306 58528 64094 671 10026 7052 6317 942 10457 5641 1513 968 1520 10261 27163 54504 6351 3988 7305 5360 27098 348 7941 1476 2495 1191 4502 8557 120892 1756 23336 171024 6581 2273 4638 1674 55679 5742 59 5121 6525 7169 2316 4900 10398 23022 7871 29951 25802 3779 4629 72 11034 4969 PMC4994294__F4 Unigenes involved in the plant hormone signal transduction pathway in SAM of Oriental hybrid lily 1879 64641 578 51411 PMC5067332__F1 Inositol mechanisms of action in cancer cells 5163 3630 6093 9475 1950 PMC5390025__F2 Host-Helminth interaction: There are two sides of immune response against a parasite invasion, one leads to worm survival in host and the other to worm killing 64806 90865 406947 100616245 407054 383 PMC5554748__F8 Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NFKB and JAK-STAT Pathway 7099 6714 6772 3553 4513 4615 PMC5974538__F1 Occurrence of plant photodynamic stress 4553 7390 7389 130749 2235 PMC6471220__F3 Transcriptional effects in zebrafish liver after feeding with 25% of maize substitution 31 3630 355 9615 348 4953 4143 1491 10295 5053 117247 55089 6651 PMC6471465__F6 Signaling pathway involved in intact or papain-hydrolyzed glycomacropeptide modulation on RAW 264.7 macrophage response to lipopolysaccharide or hydrogen peroxide 7099 4615 9817 PMC6497095__F9 Schematic view of signaling events elicited by LPS in RPE cells 5091 5337 5338 6120 PMC6619438__F2 Innate immune recognition of Chlamydia 7099 929 7096 10333 7097 7098 1969 4615 64127 115004 10392 51135 3661 PMC7292789__F1 Vertebrate complement cascades and the particular steps Lyme borreliae anti-complement protein interact 715 716 720 717 718 727 735 2271 PMC7359838__F1 Spliceosome pathway (hsa/dre03040) as enriched in module ME01 (Bonferroni correction < .05) 4809 22827 11017 10523 10569 57461 55696 4116 9716 PMC7462918__F3 Membrane trafficking of SGLT1/Sglt1 7040 3717 6446 23678 6247 PMC7547598__F6 Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages 1233 7058 3371 3455 7852 6737 64101 5897 7374 914 1791 5896 8178 53833 6693 921 5426 920 3111 4775 3690 5788 56961 3689 4609 273 4605 699 6850 1869 4998 4478 8685 27040 1032 7409 9402 1031 203068 1441 25865 8631 2207 64926 3984 814 6891 6890 PMC7547598__F8 Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages 1493 3932 962 867 2534 7535 27040 389 3702 2885 3565 1019 102724566 8915 29851 940 PMC8231932__F2 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art 57506 29110 3661 7187 7297 57762 PMC8231932__F3 Functions of Coronavirus Accessory Proteins: Overview of the State of the Art 114548 7187 1386 PMC8470522__F3 Actions and Roles of FSH in Germinative Cells 2492 652 2668 5979 255877 3400 596 389421 PMC8866957__F2 Glimpse of Programmed Cell Death Among Bacteria, Animals, and Plants 5813 11035 2879 4519 5447 828 326340 3084 55328 637 581 PMC8902753__F2 Gut Microbiota in Inflammatory Bowel Disease 79671 23411 114548 171389 64127 6774 50943 8161 PMC8909058__F4 Relevance of Aquaporins for Gamete Function and Cryopreservation 364 360 282679 5091 343 3240 367 366 PMC9046764__F6 Genomic signatures of artificial selection in the Pacific oyster, Crassostrea gigas 3690 1386 22926 10468 1956 1845 998 8491 7472 8322 329 1019 842 841 7482 147111 4087 4088 4089 PMC9105968__F5 Lactoferrin as a Human Genome “Guardian”—An Overall Point of View 983 2475 1021 1019 1017 PMC9133606__F2 Phytochemicals in Skin Photoprotection via Regulation of Nrf2 1728 5091 3569 PMC9456310__F6 SP and KLF Transcription Factors in Cancer Metabolism 2064 9314 6667 5214 857 8473 11279 2182 340485 95 PMC9459425__F1 Cold adaptation strategies in plants—An emerging role of epigenetics and antifreeze proteins to engineer cold resilient plants 878 867 23379 PMC2547860__F6 Networks among genes involved in milk fat synthesis 7436 8694 4023 3992 2170 55902 9415 2180 57678 6319 2056 7498 696 2194 31 19 7069 6721 9429 6720 133522 23175 56848 10891 5007 3638 51141 22937 10558 PMC2631405__F1 Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models 3479 5728 5163 2308 PMC2706303__F2 Bioelectric mechanisms in regeneration: unique aspects and future perspectives 847 5728 6663 PMC2745153__F2 Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling 1950 6010 3611 6774 PMC2857869__F4a Metabolic Engineering for Production of Biorenewable Fuels and Chemicals: Contributions of Synthetic Biology 3250 65220 210 PMC2944875__F2 Gene Expression Study of Monocytes/Macrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts 10140 3624 7057 9241 2022 9839 7008 3725 2033 1387 1950 2353 6497 7908 7054 3458 3562 6955 6957 3574 7124 847 PMC2959101__F4 Schematic diagram of NELL-1 signaling pathways in osteoblast cells 650 4745 4086 4089 4091 860 PMC3234268__F5 Genome Characterization of the Oleaginous Fungus Mortierella alpina 22934 25796 5226 6120 132158 2821 10423 47 54898 79603 10965 65057 39 3158 4047 6608 PMC3278439__F4 Analysis of the Fibroblast Growth Factor System Reveals Alterations in a Mouse Model of Spinal Muscular Atrophy 2885 10818 387 998 PMC3335670__F3 Action of the enteropathogenic yersiniae Ysc T3SS effectors (Yops) on host cell signaling and survival 6714 7099 387 5879 998 PMC3546685__F1 Short-patch (SP-) and long-patch base excision repair (LP-BER) sub-pathways 79661 55247 252969 5111 2237 7515 PMC3583171__F3 Significantly differentially expressed genes identified by KEGG as involved in toll-like receptor signaling 54472 8772 114609 929 100187907 4351 7975 920 PMC3760860__F6 Organized Emergence of Multiple-Generations of Teeth in Snakes Is Dysregulated by Activation of Wnt/Beta-Catenin Signalling 2932 6657 51176 PMC3867386__F8 Pre-Symptomatic Activation of Antioxidant Responses and Alterations in Glucose and Pyruvate Metabolism in Niemann-Pick Type C1-Deficient Murine Brain 3098 2539 5213 2026 2023 3939 5163 5164 4199 4200 5214 PMC3959190__F3 Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights 465 7175 4118 100312954 50976 51663 PMC4149376__F8 Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways 627 4803 7476 6424 1499 4133 1103 1621 8927 PMC4165197__F4 Action of recombinant bovine somatotropin (rBST) 3479 2885 126669 PMC4380746__F1 Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention 1356 728 718 966 613 1378 1380 721 4025 PMC4388007__F4 Significantly affected canonical pathway “interferon signaling”, as determined by IPA® analysis 3716 7297 8651 8554 596 6722 581 5696 3430 10379 3659 3437 4938 3458 4599 PMC4396380__F1 Reduced Tyk2 gene expression in Beta-cells due to natural mutation determines susceptibility to virus-induced diabetes 3454 3455 3716 7297 6772 6773 4599 7098 51311 51284 3661 3659 3660 1386 5548 PMC4474670__F3 Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity 382 1950 30846 2060 4092 387 3949 998 11311 30845 30844 91782 8027 51160 51028 51652 79643 84313 PMC4526652__F7 Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue 183 367 1636 PMC4617547__F1 Summary of unfolded protein response and endoplasmic reticulum stress signaling pathways 22926 27102 7186 83939 7494 1386 468 23645 84919 6774 3725 PMC4622660__F1 Canonical Wnt/Beta-catenin signaling pathway: OFF state 1499 4040 4041 847 10010 324 4513 4609 PMC4647707__F3 Differentially expressed genes in the toll-like receptor signalling pathway (ko04620) 7097 5879 29949 54472 4615 114609 10333 8772 3929 929 23118 51135 7189 7099 958 942 3665 1513 3661 7098 7187 PMC4670900__F4 The proposed pathway for energy production, based on the KEGG-associated proteins found in the proteome of L 3250 2597 6389 5805 PMC4670915__F5 Scheme of the metabolic effect in control and differentiated SH-SY5Y cells 4193 637 3418 23410 PMC5010449__F3 Avoidance and subversion of eukaryotic homeostatic autophagy mechanisms by bacterial pathogens 9474 8408 8678 PMC5103168__F6 Pre‐ and Post‐Natal Stress Programming: Developmental Exposure to Glucocorticoids Causes Long‐Term Brain‐Region Specific Changes to Transcriptome in the Precocial Japanese Quail 4490 4036 5673 4883 55799 55576 6869 2813 7078 PMC5117493__F6 Signaling pathways associated with differentially expressed proteins as identified by Pathway Studio 1674 7454 11034 PMC5282855__F1 Biosynthetic pathways of tetrapyrrole compounds 23242 7909 1431 PMC5488651__F3 Bacterium Helicobacter pylori is a well-studied example of a pathogen manipulating host PAK1 signalling 7099 5879 5058 3553 PMC5548957__F2 Rotavirus interactions with the host innate system: viral entry into cells and viral double strand RNA (dsRNA) induce the generation of pathogen-associated molecular pathways (PAMPs) 7098 51284 23586 10379 29110 3665 3661 PMC5627668__F1 N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities 7054 2166 7442 1312 PMC5729931__F5 Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon like peptide-1 in the paraventricular hypothalamus 1392 2740 5662 4922 PMC5904535__F12 NF-Kb signaling pathway regulates cellular inflammatory, oxidative and apoptosis 355 4353 847 PMC5986551__F2 MS and network analysis of hypoxic exosomal proteome 3486 5270 10135 2896 4017 3958 2200 4015 7057 4314 168667 2019 3913 2934 9255 6191 51138 6203 6188 6208 60 2597 9475 6238 57805 5708 3939 3308 9146 2194 10549 11316 51065 2752 5589 6143 3074 51386 1808 8566 10067 6194 8662 7431 9276 27335 6147 3190 3181 6189 10594 5702 4869 2288 3066 7175 5371 5496 4791 8175 3182 3192 3178 10949 4000 9961 4282 10226 191 8667 8663 23677 8661 8243 5591 3301 PMC5991297__F7 Pro-inflammatory AGE-RAGE signaling is activated during arousal from hibernation in ground squirrel adipose 3146 6285 2113 3725 10725 PMC6052114__F7 Models of SLC9C1 gating by voltage and cAMP 2638 770 759 285335 PMC6066739__F1 ERA subcellular localization allows the activation of both nuclear and membrane-initiated signaling pathways 6714 7018 6667 PMC6085545__F8 Primary DAEC expansion and differentiation.(A) Proliferating human DAECs and their fate after induction and feeder removal in vitro 1950 2255 2252 7356 362 PMC6095988__F2 Androgen signaling pathway in granulosa cells of the primordial follicle 367 6462 6714 8648 811 6873 6736 4088 6908 PMC6103460__F1 Major Nai influx and efflux pathways and metabolic pathways involved in ATP supply 948 4666 90550 1376 PMC6185734__F9 Magnetic fields affects microtubules via EGFR and calcium pathways 1950 4082 1956 PMC6199329__F3 miRNA-regulated pathways in preovulatory granulosa cells 23576 1894 4436 10635 990 993 1111 675 2146 9212 2177 7057 4172 6241 2305 7422 6935 3925 2099 9055 51203 55872 PMC6199329__F4 Characterization of the miRNA regulators of the human ovulatory cascade 1111 55008 4436 10450 176 993 5557 1393 1612 7422 2628 4320 10154 23002 961 1464 6659 8013 4237 1869 3280 718 10411 7298 23199 8522 4016 11170 2890 2100 6935 7057 26035 2305 PMC6258484__F5 Pathway network and MAPK signaling 1610 4351 2885 6722 7063 1386 7124 4149 355 1616 929 23118 51295 51701 2316 885 6503 4208 PMC6261607__F8 Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors 4088 4087 3550 387 PMC6454084__F1 Putative palmitoylated proteins of the mechanistic target of rapamycin (mTOR) signaling pathway 201163 6009 57521 64223 2475 51256 7249 7248 9681 81929 54468 84219 79726 8131 10641 6396 PMC6503366__F5 “Cytokine–cytokine receptor interaction”, “steroid biosynthesis” and “cell cycle” pathway and the identified regulator 654 7422 2056 1950 268 7173 1956 983 2057 5618 1017 890 8900 1869 3717 6772 4088 4090 4086 595 5111 891 9133 1718 PMC6521864__F3 Synthesis pathway of cardiolipin from lysophosphatidic acid and lysophosphatidylcholine 95 3931 283871 114971 PMC6540205__F1 Activation of the PI3K/AKT signalling pathway in mink uteri in activated versus diapause states 2475 6009 7249 672 5879 613 930 5728 572 150365 10682 1977 66037 6850 4609 4199 PMC6572125__F5 Enriched integrin signaling pathway in non-type subtype of bladder carcinoma cell lines 2534 5829 7414 2885 7094 6714 9317 1956 28964 1399 998 5747 85451 3611 55742 5728 1398 PMC6583763__F1 N-linked glycosylation in the ER 55741 80267 201595 6184 3703 PMC6637205__F4 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis 7046 10454 23607 6010 998 PMC6692341__F5 Control of fruit biochemical composition 9973 914 9350 95 55331 PMC6789471__F4 Protein–protein interaction (PPI) network of the set of DEGs/DEPs identified in the overrepresented GO Immune System Process terms 147179 10766 29108 6047 10097 8085 5747 4689 56940 5296 5609 7706 5578 405 55072 11140 4609 3725 811 8600 9935 3055 5641 5691 5710 5702 3550 168002 8772 1175 6957 673 5771 784 5713 PMC6815045__F3 PI3K-Akt signaling pathway 2475 1977 6009 7249 1975 9846 5879 613 6850 4609 761 5934 5728 572 842 150365 4193 6494 930 4199 6256 PMC6834141__F2 Simplified overview of the signaling pathways in the target cells presented in this review that are relevant for the development of a pharmacological therapy rationale 3976 3479 8772 6774 595 PMC7076804__F5 Cross-talk between activation of the DDR and the IR upon infection with genotoxin-producing bacteria 472 3553 3569 3578 3586 3596 11009 PMC7291293__F3 Summary of caveolae/CAV-1 in signal transduction during virus infection 6714 5879 857 387 4035 PMC7598260__F7 Visual representation generated by MetScape (CREGN) application of the Urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine, a common pathway among the three species 1725 6723 6611 2936 383 4846 2882 2879 384 4842 2878 435 257202 440 2678 1475 5182 162417 79731 91703 443 PMC7705468__F2 Mechanisms involved in the tendon stem/progenitor cells during the process of diabetic tendinopathy 3479 2475 642658 64102 6662 860 650 2357 246 PMC7720688__F3 Biological mechanism of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection 3553 6868 7113 59272 PMC7734173__F1 Endosomal and cytosolic DNA sensors and their related signaling pathways 51428 170506 4361 1660 115004 9447 57506 29110 3661 3603 3665 PMC7829553__F2 Currently known NAD+/NADH- and NADP+/NADPH-dependent peroxisomal enzymatic reactions, transport of NAD+/NADH, NADP+/NADPH, NMNH+, AMP, and 2′,5′-ADP, and role of shuttle systems 5827 4190 3945 2819 3417 83594 1628 3929 26063 5194 5195 5830 PMC7854359__F4 Conservative route to genome compaction in a miniature annelid 7124 5728 4485 9113 26524 2475 7249 7248 6009 4609 4149 4335 4613 4610 PMC7869416__F6 Schematic diagram illustrating Eif2s3y functions in goat SSCs 2668 2674 5916 PMC8049318__F1 MiRNAs and coding genes involved in the milk fat synthesis pathway 84803 948 6319 95 2170 2180 23175 4023 8694 2194 31 5019 622 55902 84532 PMC8084285__F2 Promising role of defensins peptides as therapeutics to combat against viral infection 59272 126669 9118 PMC8226020__F5 Calcium Binding Protein S100A11 and Its Roles in Diseases 6282 1499 4089 4087 4088 PMC8254040__F1 Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection 5901 2733 8021 8480 4928 4927 23636 10482 57122 55746 23279 79902 6396 79023 348995 55706 23165 23511 9631 9818 53371 9972 10762 7175 29107 9688 129401 9883 PMC8330548__F2 Cadmium Exposure on the Immune System and Immunoregulation 847 958 7421 114548 9817 PMC8431321__F2 Interplay between Hepatitis E Virus and Host Cell Pattern Recognition Receptors 57506 140885 3661 29110 7098 51284 7097 4615 7099 80194 PMC8471532__F8 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients 59272 1998 9817 PMC8473751__F3 Insight in the Recent Application of Polyphenols From Biomass 58157 2730 1728 PMC8509025__F1 Molecular Functions and Pathways of Plastidial Starch Phosphorylase (PHO1) in Starch Metabolism: Current and Future Perspectives 4342 126669 2733 2875 2444 101448070 PMC8583789__F7 RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair 55183 149840 54537 28990 672 4361 580 PMC8615192__F1 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 7057 10468 79875 4838 148738 25805 387 4091 4092 1616 4087 4088 9978 8454 6500 4089 1874 PMC8615192__F5 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 613 6850 930 23178 5728 7249 572 6256 5934 84188 51083 PMC8615192__F6 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 3630 3643 717 1537 5728 51701 6502 4193 1017 619538 666 10365 9140 472 7808 PMC8615192__F7 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 27040 5624 23440 8205 790 PMC8624197__F3 Bioconversion of Lignocellulosic Biomass into Value Added Products under Anaerobic Conditions: Insight into Proteomic Studies 1636 3045 100187828 PMC8708342__F2 Species-Specific Differences in Aryl Hydrocarbon Receptor Responses: How and Why? 196 405 1316 1869 100379198 PMC8888908__F1 Autophagy in the Neuronal Ceroid Lipofuscinoses (Batten Disease) 3932 9140 10533 83734 9776 8408 64422 9474 22863 8678 7405 PMC8905337__F1 Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs 7939 7018 10220 2662 9573 2657 2660 650 151449 8200 392255 4090 4086 6997 4087 4088 PMC8998447__F1 Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson’s Disease 1509 2475 3920 8408 9474 9140 10533 PMC9047687__F7 Whole Transcriptome Profiling of the Effects of Cadmium on the Liver of the Xiangxi Yellow Heifer 9370 948 126669 2147 7249 25886 335 5360 4023 7350 3611 7316 4312 355 390928 PMC9048904__F6 Thirty years of resistance: Zig-zag through the plant immune system 2241 23125 23261 5976 26019 PMC9133606__F3 Phytochemicals in Skin Photoprotection via Regulation of Nrf2 9817 1728 4312 4314 4318 4286 PMC9143056__F2 Inflammation by Plant-Derived Nutraceuticals in Tendinitis 6774 3596 4513 PMC9158378__F1 Sonic hedgehog signaling pathway is susceptible to both genetic and environmental dysregulation 2619 6469 84976 50937 5727 91653 2736 6608 PMC9264807__F1 SLC7A11 in Cancer: Friend or Foe? 23657 2744 3458 2879 PMC9264807__F2 SLC7A11 in Cancer: Friend or Foe? 9817 9055 7874 468 23657 51780 693142 51569 3667 55611 8678 6520 960 PMC9348444__F4 Comprehensive role of SARS‐CoV‐2 spike glycoprotein in regulating host signaling pathway 8829 59272 7113 7096 10333 3663 PMC9348623__F6 Molecular Mechanisms of the Convergent Adaptation of Bathypelagic and Abyssopelagic Fishes 6010 6011 6714 PMC9456310__F7 SP and KLF Transcription Factors in Cancer Metabolism 2840 9055 6667 687 7358 5743 95 PMC1635984__F3 MRNA expression levels in TGFBeta-treated T84 epithelial cells compared to control cell culture 1950 3479 2246 7472 54361 3481 1956 8322 5728 2885 2887 6500 8454 9978 1856 4092 6654 6655 208 6237 1499 5594 324 7088 51176 51701 1387 PMC2575513__F2 Diversification of the innate immune arsenal in amphioxus 7097 7099 4671 114609 4615 64127 10392 7124 PMC261890__F8 T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression 920 27040 3932 6714 2475 3702 PMC2684550__F2 In MSTN-null mice, regulators of the PI3K pathway and cell survival/apoptosis likely contribute to muscle hypertrophy 5728 65018 1603 332 PMC2699967__F2 Signaling pathways initiated by TLR-2 and TLR-4 activation 929 7097 10333 29110 7189 4118 4615 3654 PMC2712597__F6 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways 6007 27304 9054 81605 4553 PMC2742468__F1 Metabolic cooperativity between oocytes and cumulus cells, and the role of oocyte-derived paracrine factors in promoting metabolism in cumulus cells 10991 9210 2661 5214 226 2023 3939 7167 4598 10654 10682 2224 6713 PMC2771360__F4 Microglia Are Mediators of Borrelia burgdorferi–Induced Apoptosis in SH-SY5Y Neuronal Cells 5728 545 472 28996 1499 4193 1869 2932 9997 5111 57103 94005 581 1019 7490 133746 2765 1537 PMC2784025__F8 Proposed model of the underlying mechanism by which NeuroD6 may bridge neuronal differentiation to survival 317 842 63974 331 836 PMC2784807__F3 Cyclin-dependent kinase (CDK) 5 (A) and Insulin-like growth factor (IGF)-1 signaling pathways (B) among 2,102 differentially expressed genes due to intramammary infection with Streptococcus uberis 4803 4026 9487 545 5058 3479 351 3480 PMC2822437__F1 Heterotrimeric G Proteins and Apoptosis: Intersecting Signaling Pathways Leading to Context Dependent Phenotypes 7124 581 8772 PMC2838843__F3 PTEN signaling pathway 5728 4099 572 PMC2887678__F1 Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells 79868 440138 85365 8818 79053 29929 84920 10195 PMC2896874__F11 Schematic overview of MAPK-regulated processes that are thought to couple light to the SCN clock during the early night 9575 406 1977 3726 5187 PMC2902700__F6 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE STIMULATES THE PROLIFERATION OF COLORECTAL CANCER CELLS 2695 2696 2475 PMC2955882__F4 ENaC and ASL volume regulation 1080 367 84890 PMC3012432__F7 Diagram illustrating the PS–Tyro3–Akt cell survival signaling pathways 7301 4193 572 581 PMC3031501__F8 Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells 2932 7249 208 2475 6502 1017 PMC3035594__F3 Integrated view of Wnt pathway 7472 1856 1452 4609 3725 5519 85409 7481 387 PMC3060778__F4 Comparative and demographic analysis of orangutan genomes 9331 10825 53947 9514 338596 3074 PMC3091762__F7 IPA representation of the canonical pathway for leukocyte extravasation signalling in cluster 4, 24 hours post-infestation with P 6010 759 7006 100124696 1398 PMC3119055__F4 Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events 5327 5069 2487 2308 5328 2274 6004 1956 1622 3482 PMC3119520__F7 Predicted d-galactose network in Y. pestis 6697 2592 2582 PMC3240703__F2 Glycosylated Synaptomatrix Regulation of Trans-Synaptic Signaling 474168 7038 238 28964 PMC3261702__F4 Structural coverage of the core vision pathway and its links to other functional modules 6010 1259 2638 388531 8787 6295 5957 5132 5147 5579 3845 367 815 6011 203068 10376 7277 84790 2596 5580 5587 5872 378 5898 5899 382 400 87 88 81 5880 4619 4628 4632 419 6102 6709 5604 3419 PMC3270028__F6 Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling 3661 57506 29110 PMC3307371__F8 Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus 627 2932 2931 3297 PMC3372091__F3 Mechanisms underlying the biological effects of polyphenols 3603 627 9817 PMC3419804__F1 Autophagy, Myocardial Protection and the Metabolic Syndrome 3667 5163 5728 7249 7248 6009 718 8408 PMC3440368__F7 Disturbed Relaxin Signaling Pathway and Testicular Dysfunction in Mouse Offspring upon Maternal Exposure to Simazine 59350 4846 4843 4318 PMC3441782__F6 Molecular network of downregulated genes in U373MG cells following exposure to ET-770, the compound 1a 367 685 3725 126669 340441 572 PMC3441782__F7 Molecular network of upregulated genes in U373MG cells following exposure to ET-770 derivative, the compound 3 1874 5885 142678 4118 6502 991 5111 1017 999 2161 PMC3445623__F2 Gene Expression and Functional Annotation of the Human Ciliary Body Epithelia 2885 27043 100187907 8431 5241 23426 6908 6714 8841 3484 PMC3473259__F2 Main pathway disorders leading to muscle proteolysis, atrophy, hypoxia and anti-oxidant response 2932 2475 64400 207 23216 10549 2308 1982 8703 7326 1201 55743 867 5213 114757 3091 2027 1158 2597 4282 4696 PMC3518872__F3 Top three networks of significantly associated molecules in TGFB1+LPS+IFNGamma-treated astrocytes 9023 55718 2956 23406 8797 7818 26227 83699 57509 55800 3960 9582 29948 64782 2745 8626 5886 1307 63979 23474 54541 23515 24149 717 2760 9435 79874 7157 23567 22891 79971 112858 5326 51002 50484 57333 4814 54861 79188 10231 9516 11182 10360 84901 27297 255027 8777 3797 54069 51512 25984 2937 8079 80196 22929 687 9459 710 10965 7871 873 2739 1448 124925 3064 9217 5153 6723 149175 3768 3776 27244 5611 2027 7175 10391 PMC3518872__F4 Three IPA Canonical Signaling Pathways: CD40, IL-1, and Chemokine Signaling in TGFB1+LPS+IFNGamma-treated astrocytes 958 7189 7186 7185 7188 6774 54472 4615 7187 51295 23118 10454 85451 3716 9261 466 3383 4049 2208 1234 1232 7852 387 9475 6010 27035 PMC3518872__F6 GPCR Canonical Signaling Pathways 150 814 2885 6714 2549 PMC3529810__F7 Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response 8453 4738 8454 123228 7099 3569 3458 PMC3564524__F10 Novel signaling pathways involved in apo(a)-mediated effects on vascular endothelial cells 948 7097 6010 6714 5728 1003 2932 1499 PMC3579806__F4 Differentially Expressed miRNAs after GnRH Treatment and Their Potential Roles in FSH Regulation in Porcine Anterior Pituitary Cell 1950 4313 4323 2885 6714 998 7018 2488 2798 1956 PMC3743449__F4 Classical example of NFKB is the heterodimer of p50 and p65 and the classical activation pathway entails the release from its association with an inhibitory molecule of the IKB family 3553 3458 6395 7185 7415 331 7412 3383 7018 PMC3767435__F2 Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia 23643 929 114609 353376 4615 51135 695 3654 148022 3656 54472 7189 57162 10454 23118 7182 9020 1147 3661 3551 5599 1432 4792 5970 4790 3725 3665 4049 1437 1440 3456 3458 7124 3627 6347 3554 7132 7128 8717 841 8772 8767 6416 2002 3146 23162 7335 4798 4795 4793 941 3329 942 3303 9450 56667 4513 5465 8993 7334 PMC3889810__F6 Whole genome and gene set enrichment analysis of cells expressing mutants of neuroserpin show an upregulation of the cholesterol pathway when polymers are expressed 3157 6720 6721 1717 3156 4598 50814 10654 1595 3422 4597 4047 2224 6713 2222 PMC3932028__F5 Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells 9693 847 11069 10411 2002 PMC3946160__F4 Glutamate, BDNF, insulin and glucagon-like peptide 1 (GLP-1) improve neuronal bioenergetics and protect the neurons against neurodegenerative disease and traumatic injury 627 2247 2475 PMC3962345__F4 Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice 4082 1020 998 2902 1958 PMC3966620__F1 Cl− channels in cardiac myocytes 1080 4434 367 1179 PMC3980079__F1 Heart Failure and Loss of Metabolic Control 4023 7038 948 95 5315 5091 847 1376 PMC4227274__F9 Cellular defense mechanisms induced by IPNV infection in CHSE-214 cells 7098 572 6772 PMC4314327__F3 Macrophage immunoregulatory pathways in tuberculosis 3569 4151 923 PMC4411413__F2 Differential expression of genes involved in MAPK signaling pathway in mouse ovaries 140738 1843 5566 4137 11221 10125 5906 627 5583 673 6722 1950 2885 4893 5533 5921 2768 2316 3725 100131060 5058 5494 835 2002 7786 204 834 2645 355 1616 4149 10454 9843 51295 1647 3550 4969 6418 PMC4411486__F2 Predicted co-regulation of genes in the MAPK signaling pathway targeted by the downregulated miRNAs in WAT during torpor 1610 22944 4351 4342 355 3725 2645 1616 4149 8195 929 PMC4411486__F4 Predicted co-regulation of genes in the TGFB signaling pathway targeted by upregulated miRNAs in WAT during torpor 4089 3458 8454 6500 387 3624 4838 PMC4452922__F7 IFN pathway in response to virus infection at 24 hpi 3458 8554 10379 581 5696 3659 PMC4510916__F2 Lf intervention upregulates the neurotrophin-signaling pathway in postnatal piglets 1398 10818 9261 4803 627 572 2932 PMC4638047__F7 Pathway analysis highlights APP is a central hub interacting with nearly 40% of candidate molecules in EGS 79784 29937 4155 22883 375790 2771 6616 6812 5202 535 10471 55742 2029 23770 2289 PMC4646468__F4 Comprehensive MicroRNA Expression Profile Related to Hypoxia Adaptation in the Tibetan Pig 4513 998 9261 6714 842 572 PMC4685214__F1 Signaling pathways leading to gonadotropin-induced activation of MAPK3/1 in preovulatory follicles or cultured cumulus-oocyte complexes 2492 374 2069 6714 1956 1432 5743 5595 5594 1051 2494 1583 5241 6770 3037 5806 7130 PMC4711587__F3 De Novo Assembly and Characterization of Early Embryonic Transcriptome 51701 25805 50964 2619 7546 PMC4748524__F1 TLR signaling pathway genes 7100 7099 7097 10333 7098 54106 51311 51284 4615 54472 114609 51135 7189 7187 23118 3665 3661 3663 PMC4791395__F3 Stealth strategies of Brucella 920 8178 7097 7099 PMC4842340__F2 Involvement of the prohibitin (PHB/PHB1) in granulosa cell (GCs) survival and differentiation functions 596 581 4976 6770 PMC4855030__F5 Interaction network of innate immunity related proteins 7284 6143 1398 9188 4904 3710 801 1994 3609 5093 1660 8087 4343 5094 1653 1654 PMC4865316__F8 Scheme of the mechanisms by which the lack of ZO-2 triggered cell hypertrophy 324 5728 5163 1499 2475 2932 PMC4958499__F1 Looking beyond structure: membrane phospholipids of skeletal muscle mitochondria 5091 10400 6901 5662 PMC4970921__F1 Microarray and bioinformatics analysis of tendon fibroblasts treated with PRP or PPP 10232 4318 7043 5270 4314 4969 4322 25903 4319 3934 718 63923 5359 7097 6648 10912 1051 2067 151887 1410 PMC4994041__F7 The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis 10413 60485 1499 PMC5009320__F5 3′-hydroxy-3,4,5,4′-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model 1017 355 841 637 581 836 94005 842 64065 3486 2475 5728 7249 4193 6477 64326 PMC5043072__F3 Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection 57584 203068 3064 7314 23524 23224 1288 51514 6672 2494 55929 55900 8412 6242 8648 1951 5934 2113 29766 3638 7534 1674 7184 4613 5339 140885 27022 673 4629 324 6261 5175 6710 2834 2475 5568 116986 23049 7249 79109 1856 PMC5061430__F6 Role of the Tomato Non-Ripening Mutation in Regulating Fruit Quality Elucidated Using iTRAQ Protein Profile Analysis 847 4151 1312 100187907 22926 8726 578 790 2077 PMC5116673__F3 Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis 4223 80781 3655 3485 7040 4320 1827 50848 2624 57509 2255 4086 6405 652 3161 53358 306 1264 64065 64388 3685 1356 4152 5077 657 2113 4211 4222 2263 6910 6469 PMC5295490__F4 B3AR signaling activation in cardiomyocytes 5350 6262 759 PMC5327483__F4 New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin 841 8772 10454 54472 3553 7099 23118 4615 51135 3654 114609 7189 PMC5328618__F8 Model for how APC mutations affect insulin-induced dynein movement toward MT minus ends 324 81565 2932 3630 PMC5337806__F3 MAPK signaling pathway 3925 4803 627 1950 2002 4351 5894 4342 1956 2316 3725 998 4485 2645 4149 4208 994 1616 23118 51295 929 7189 51701 PMC5337806__F5 TGFB signaling pathway 25805 4090 4086 4089 3458 7124 4091 4092 9978 8454 64750 57154 6500 7046 1874 4087 4088 6667 1616 387 PMC5344275__F2 Signaling mechanisms responsible for promotion of cell survival mediated by HGF–Met pathway 3082 355 2549 581 572 PMC5345234__F5 MAP2K5-centered gene clusters exclusively based on pathway and physical interactions 4193 2736 54830 1437 8405 5447 50937 6533 5979 50507 7249 2313 9869 59067 1785 5062 8807 3718 11127 3600 1134 2022 3908 3480 6915 920 PMC5361837__F4 Examples of functional networks of regulated genes shared by different tissues 119559 1201 347734 10131 11021 6648 5660 1075 826 5446 7204 9423 10133 667 22873 5684 221120 81579 64754 11309 116832 9045 65005 6054 6123 PMC5453624__F5 Comparison of the adolescent and adult mouse prefrontal cortex proteome 627 1270 4909 9229 1902 4905 622 2596 1400 7416 1809 2597 5610 10814 5530 6812 253260 5582 29801 2173 2171 8874 4782 7385 1465 2475 6310 5725 2949 PMC5453624__F7 Comparison of the adolescent and adult mouse prefrontal cortex proteome 4155 4137 135 351 1211 3831 5663 7416 2026 2597 2170 6622 4843 816 10814 207 5728 7157 7054 815 10048 1072 5468 2332 5315 3178 PMC5489693__F7 Gene interaction network related to lipid metabolism of DEGs between WC and WRR chickens 376497 1071 152137 10499 7763 55252 7461 1611 3097 84665 4023 1374 19 PMC5512429__F3 Cellular signaling pathways and transcriptional regulatory circuits mediating physiologic cardiac hypertrophic growth 3479 3667 5266 163732 4899 PMC5569703__F1 Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility 324 959 958 6356 7124 4155 8288 2207 PMC5593197__F6 Equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila 5898 3725 4089 4086 PMC5655361__F2 Signaling networks in aging 9798 5163 7249 7248 65095 6446 207 208 PMC5672004__F8 Pathways summary showing identified kinases in BTV infected cells 1612 23178 1915 5062 1263 572 PMC5725281__F9 Cardioprotective effect of CAPE-oNO2 23411 4899 4087 4088 581 6647 PMC5745011__F2 Pericytes of the neurovascular unit: Key functions and signaling pathways 5159 4035 6714 2885 2475 2308 6667 1956 214 PMC5746469__F3 Initiation of oocyte and follicular growth 5728 5163 207 5266 7249 7248 2475 1978 6198 PMC5768609__F1 Schematic diagram depicting the role of miR-27a in Mycobacterium avium subspecies paratuberculosis (MAP)-mediated signaling pathways in macrophage 7096 7097 7099 23118 10454 3553 26136 PMC5832853__F7 Pathways regulated by selected HPG axis-related hormone and protein in male reproduction as predicted by Pathway Ontology Database and KEGG Pathway Database 3814 2488 108 1081 2798 3973 8431 1392 367 1583 6342 7110 9612 6770 PMC5845754__F10 Proposed model for Marf-mediated ER stress in FRDA flies 2271 2395 5163 PMC5846438__F1 Possible signaling mechanisms of amino acids in intestinal inflammation in the ECs are illustrated 59272 846 2475 PMC5846438__F2 Signaling pathways of different amino acids in intestinal inflammation 59272 846 2475 PMC5850397__F1 Mechanism of apoptosis induction by Vesicular stomatitis virus (VSV) in the infected cell 637 8480 4928 PMC5896143__F1 Violacein biosynthetic pathway (a) and plasmid maps of the complete (b) and partial (c, d and e) operons for violacein biosynthesis 100187761 84273 7038 54820 4199 4118 572 PMC5962685__F8 ALA metabolic pathway of cucumber under NaCl stress 7454 5447 27159 PMC6019448__F7 Avian and mammalian OASL involvement in RNase L and RIG-I signaling 57506 79092 1283 6041 8638 PMC6059697__F11 p53 signaling pathway obtained from the DAVID Database 472 545 355 637 4609 581 64065 4193 2668 7249 5728 6477 64326 1869 PMC6120108__F3 Downstream consequences of neurotrophin signalling pathway affecting gene function and ER stress marker is possibly implicated in progression of RGCs axon damage in glaucoma 134430 4653 7316 10133 54499 7494 83939 1388 468 PMC6163297__F6 Schematic drawing of the possible signalling pathways regulated by PACAP in bone formation 654 655 3549 6469 5727 6608 4090 4086 4089 860 2735 PMC6180192__F1 Nuclear factor erythroid 2-related factor 2 (NRF2) activation 9817 9978 1431 6500 PMC6190866__F6 Differentially regulated genes by IRF7 overexpression upon H6N2 infection 79094 415116 220 3400 2328 27122 81617 4047 54510 81616 23500 8205 3589 100505573 10137 9060 10750 2678 4060 10631 1051 113878 9734 147495 10297 84722 2303 83698 2224 3131 10156 4773 114881 1734 3397 122953 5654 7975 6307 56985 284654 11096 92 79974 2670 1822 4117 6497 PMC6196465__F2 Lactose synthesis pathway in porcine mammary gland 3099 3098 5236 7360 3906 2592 2582 2683 PMC6201924__F4 Proteomic analysis of Lactobacillus casei GCRL163 cell-free extracts reveals a SecB homolog and other biomarkers of prolonged heat stress 6120 64853 5162 PMC6241212__F2 Innate antiviral immune responses during viral infection 9636 7098 7297 11274 6773 6772 51284 54106 57506 7189 7187 10010 3550 10379 3458 4599 51311 PMC6271345__F6 Proposed mechanisms underlying the cellular responses to t-BHP after pre-treatment with Rb1 via Nrf2/HO-1 signaling pathway 4094 6648 847 1728 9817 8452 5925 PMC6274847__F2 Proline, ornithine, and arginine metabolism and transport in plants 5009 11113 58510 PMC6291520__F6 Graphical summary 2475 9474 10533 PMC6314538__F3 Cell cycle timing and regulation of replicative histone genes 4863 6908 4609 7884 79670 4678 PMC6356823__F2 Predictive pathway for polyamine synthesis in microalgal cells 549 1611 10993 6611 PMC6357531__F3 Proposed model by which polyphenols may modulate oxidative stress-induced pathways including Ang II, VEGF and TNFA 2475 50507 4318 4313 23411 PMC6390476__F1 Schematic overview depicting regulatory pathways for PYY and GLP-1 secretion by enteroendocrine L-cell 5697 2865 2867 2864 139760 PMC6517553__F3 General principle of the HSV-TK suicide gene system 7124 8772 355 472 PMC6540205__F3 Activation of the prolactin signalling pathway in the mink uterus in activated versus diapause states 3717 5617 7054 2645 PMC6546959__F4 Proposed ternatin biosynthetic pathway 2638 2641 718 717 727 PMC6555274__F4 TGFB signalling pathway with FOXN3 25805 4089 3458 4092 1112 9978 6500 4052 6667 387 10468 5308 4838 8454 1616 PMC6637205__F3 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis 6502 2475 64798 PMC6637598__F2 Wnt/Beta-catenin signal transduction pathway 4040 4041 1499 324 607 PMC6637639__F1 Interaction network of proteins underexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 82) 722 3426 3075 721 1314 629 7169 22875 2697 26998 83716 7251 249 9945 727 718 2673 183 730 2495 162 3053 2192 10721 7448 100423062 307 3827 2147 4925 2244 1191 710 462 2266 2638 5340 3273 1356 5345 2243 2019 213 259 12 3697 7123 350 1 2 9590 7018 3263 140683 335 3250 6284 8972 336 3339 3698 319101 9370 7276 1066 56616 2934 7045 8639 5806 3043 3040 PMC6637639__F2 Interaction network of proteins overexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 116) 4939 5660 6723 27095 6418 80854 830 79174 8452 4327 894 1108 56647 6050 1642 2170 5754 7402 1428 9188 57522 10797 471 27101 10916 6319 22827 4345 31 54914 2194 8833 1809 60528 23640 23768 25814 2181 23225 6813 7372 5481 3838 2582 37 11260 6204 25996 1956 10527 9352 4597 134147 65987 6160 11332 6904 689 9630 55920 1491 84817 3692 6424 5213 10170 5198 392 27250 80155 PMC6769682__F5 Receptors used by chemerin, visfatin, resistin and apelin for their signaling pathways 1240 9034 4919 1634 PMC6899955__F1 Screening of Mtb virulence proteins that interact with proteins from macrophages 22934 5478 5662 4099 PMC6928879__F1 AHR-dependent signaling pathways 196 1956 405 PMC6967385__F2 Mouse gene expression affected by biofilm status 5360 2170 4023 1376 3611 7316 364 PMC6985208__F2 Signaling pathways associated with highly differentiated proteins in X spermatozoa 4957 374291 26330 80150 7384 32 3939 3419 7167 2597 4513 PMC7072529__F1 Hypothesised regulation of extracellular matrix composition by the cilium and ciliary proteins 759 6608 5727 378 90410 4035 27152 4322 176 7078 PMC7140873__F2 Analysis of different miRNAs families and their target genes implicated in the regulation of flower induction 4602 377 378 PMC7145358__F3 Intra- and intercellular modulation of melatonin synthesis 2638 15 4199 PMC7172983__F1 CGAS-STING pathway of cytosolic DNA sensing 26100 7297 3716 6772 6773 115004 29110 3661 8408 79065 197358 PMC7236745__F3 NF-kB/E2F/Rb and p53/p21 pathways by proteasome.NF-kB/E2F/Rb pathway: under unstimulated conditions, NF-kB is kept inactive in the cytosol by IkB inhibitor 324 4193 1017 10309 5111 983 891 PMC7280204__F8 Signaling pathways involved in osteocyte mechanobiology 50964 5732 5734 10023 6714 4087 4088 6010 5228 1513 4322 PMC7340679__F7 Probable mechanism of antiobesity activity of mistletoe 4023 847 355 PMC7487062__F4 MDA-9/Syntenin/SDCBP: New insights into a unique multifunctional scaffold protein 4313 4087 6714 7046 6774 7422 4318 387 998 1956 2932 1499 3611 3485 PMC7606273__F1 Autophagy and UPR pathways as well as their interconnection in SARC-CoV-2 pathogenesis 1636 468 8678 2475 22926 PMC7606576__F3 WNK/SPAK/CCC signaling pathway in cell volume homeostasis 65125 65267 130497 PMC7654589__F2 Canonical PINK1/PARKIN pathway 65018 55486 7415 PMC7672569__F2 Targeted signalling pathway involved in endothelial cells (ECs) activation and vascular smooth muscle cells (VSMCs) proliferation and migration during intimal hyperplasia 7422 6714 5163 387 5241 759 PMC7672575__F5 Signaling pathways of MD-2/TLR4 axis that lead to stimulating the immune responses 7099 114609 4118 4615 3654 51135 29110 9021 7189 3553 3665 3661 23118 257397 10454 PMC7672575__F7 Potential antiviral mechanisms of action for honey contain caffeic acid, CAPE, galangin, and chrysin against SARS-CoV-2 59272 51083 5478 PMC7691375__F1 Comparison of mouse and human pro-resolving macrophages 383 3553 54106 7097 7099 3603 7052 PMC7722149__F1 Topical L-thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? 5594 6957 2475 6955 1735 1734 PMC7785807__F4 miRNA expression on cellular connectivity and activities with different Toll-like receptor regulation and molecular function of the cellular signaling pathways (A) 7096 7100 51284 4615 51135 3654 51311 7098 574463 7189 29110 10454 23118 3661 3665 406994 100302148 3603 1232 7097 54472 8772 3565 3929 929 114609 920 130749 1513 PMC7829553__F3 Currently known FAD, PLP, ThPP, FMN, and heme-dependent enzymatic reactions in the peroxisomes and transport of FAD, PLP, ThPP, heme, FMN and AMP 5830 5194 5195 5191 54363 83594 PMC7865717__F3 RSV could prevent oxidative stress involved in the development and progression of ocular diseases such as age-related macular degeneration (AMD) 6120 7422 2444 PMC7902093__F2 Environmental mechanisms of orofacial clefts 9049 196 6714 405 57491 2908 7039 860 1674 PMC7902093__F3 Environmental mechanisms of orofacial clefts 1499 581 836 650 2627 2255 6469 PMC8117616__F7 Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria 79923 7450 7148 3690 2791 55872 1499 7249 4193 388 1103 5163 PMC8124582__F2 Posttranslational Modification of Waxy to Genetically Improve Starch Quality in Rice Grain 5236 55276 2203 84916 PMC8258107__F1 Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation 29850 255022 119395 5330 7442 1803 PMC8400620__F5 Comparative Pan-Genome Analysis of Oral Veillonella Species 64080 51071 2582 2597 5091 4200 7360 6390 84693 PMC8471532__F9 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients 23411 4318 847 4353 4025 PMC8473751__F6 Insight in the Recent Application of Polyphenols From Biomass 574493 3608 2920 2919 693207 2303 1871 23411 5728 5230 4313 4318 331 PMC8484365__F2 Endocrine Disruption and Reproductive Disorders: Impacts on Sexually Dimorphic Neuroendocrine Pathways 2078 7018 1950 1956 PMC8516344__F3 Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation 627 6262 10253 1283 PMC8600187__F4 Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity 4118 1728 847 3569 7099 4615 3596 3565 PMC8615192__F2 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 1101 7450 1758 1832 100187761 960 948 961 PMC8615192__F3 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 2932 6502 1874 5266 4999 4171 4172 23595 5000 4087 4088 4089 1017 1810 923 4193 5111 1022 8318 924 10926 993 699 9184 9126 10274 10735 5885 999 PMC8615192__F4 Transcriptomic Profile of New Gene Markers Encoding Proteins Responsible for Structure of Porcine Ovarian Granulosa Cells 126669 2885 7408 3611 1398 572 3725 2002 PMC8651982__F1 T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development 343472 2932 324 6932 4040 4041 3065 PMC8651982__F5 T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development 1956 51366 331 6932 28996 51176 PMC8740192__F1 Myostatin on the Growth and Development of Skeletal Muscle 4089 4092 4087 4088 2475 4617 PMC8846937__F1 Pathophysiology of stress granules: An emerging link to diseases (Review) 10146 7072 10399 2521 PMC8869711__F1 Selenoprotein Tissue Homeostasis in MetS Programming: Energy Balance and Cardiometabolic Implications 2876 5728 7249 2475 7248 6403 PMC8956889__F2 Ileum transcriptional response to prolonged supplementation with phytogenic product containing menthol, carvacrol and carvone 990 23595 4999 8318 5000 5001 81620 4998 23594 10926 PMC8985231__F8 Intercellular Communication in the Islet of Langerhans in Health and Disease 5140 6752 2045 2043 PMC9086899__F4 BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications 4090 4086 4089 659 7018 331 10454 1386 6722 PMC9104626__F3 Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway 90550 8772 572 9021 581 604 7054 466 PMC9201425__F3 Antimicrobial Peptide Expression at the Ocular Surface and Their Therapeutic Use in the Treatment of Microbial Keratitis 929 51135 7189 7421 2353 1956 PMC9213282__F1 Influence of endophytes on rice fitness under environmental stresses 2077 4602 6655 PMC9218868__F2 Multifunctional Roles of MicroRNAs in Schistosomiasis 4089 7421 4087 4088 10507 4092 PMC9228579__F3 Immunobiology of Nipah Virus 7297 6772 6773 6774 6775 10379 PMC9252087__F2 PCycDB: a comprehensive and accurate database for fast analysis of phosphorus cycling genes 5805 5814 5813 132 7808 22934 117159 1854 PMC9356074__F1 NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism 4837 10135 4860 952 203447 65220 23475 PMC9386258__F1 Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism 9049 196 405 1543 3383 3553 3569 1012 4314 1545 7412 4513 PMC9455248__F5 Lipidomics and Transcriptome Reveal the Effects of Feeding Systems on Fatty Acids in Yak’s Meat 2194 4199 11001 6319 30 PMC9483736__F8 Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress 6774 2475 2064 5335 3576 330 51196 3595 3577 3579 7046 3371 94 7048 PMC9534503__F6 Species unique MEGENA modules 55630 8574 221472 83985 311 23029 3135 84335 2178 4605 1633 9833 55388 7625 22974 1894 203068 3838 60485 55721 669 10493 567 25891 22978 64943 23339 55596 1520 PMC9560141__F5 Similarities and differences in circadian control of transcript accumulation in key genes involved in primary metabolism and signalling 3240 5236 101448070 5230 100196919 106049960 PMC9580404__F3 Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis 3718 3554 5978 7046 PMC9610432__F3 Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model 7097 929 6885 7706 10010 3458 10379 3717 7297 PMC9610432__F4 Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model 7097 10010 3717 PMC9774615__F1 Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes 27235 51004 2230 112812 2232 23590 57107 51805 3652 84274 56997 57017 51117 10229 93058 80219 PMC9841179__F3 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases 115004 29110 3661 PMC9841179__F6 Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases 260431 619501 4397 PMC2063819__F7 The newly identified NT3-activated signaling pathway 382 160622 8161 5879 PMC2194118__F6 Molecular dissection of the signaling cascade underlying BCR-controlled integrin A4B1-mediated adhesion 613 4067 6850 930 5163 695 29760 5336 PMC2394659__F3 Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration 387 960 399 7070 58494 5879 4689 4267 5829 1398 PMC2491704__F3 Recycling pathway of acetylcholine (ACh) synthesis, release, action and breakdown at a cholinergic nerve terminal 1103 43 590 PMC2646065__F8 Proposed model involving GSK-3 inhibition and the mTOR pathway to stimulate human Beta-cell growth and proliferation 3479 3667 8660 7248 6009 1499 2475 1977 PMC2683871__F6 p53-regulated pathway analysis using the Ingenuity Pathway Knowledge Base (IPKB) 4314 5054 64065 3732 7056 10010 54541 6275 203 22822 26999 4790 2908 2099 1869 7251 902 7707 10769 7157 94241 9134 1316 133746 5178 3151 10923 6651 1477 8556 27244 PMC2712597__F1 Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways 9636 55236 4738 6612 7341 51569 9140 23766 11337 10533 11345 64422 PMC2724309__F2 Steroidogenesis pathway: Steroids are in bold; enzymes and cholesterol transport proteins are in italics 706 6770 1583 PMC2736291__F2 Diagram shows the cell signaling pathways, which were involved in postconditioning 5728 5163 572 2932 1499 PMC2754444__F5 T-Cell Activation Pathways Generated by HIV-Modulated Proteins 915 8431 867 7535 3558 1399 2885 7454 6464 6714 PMC2756474__F7 CREB Mediates Prostaglandin F2Alpha-Induced MUC5AC Overexpression 5228 3553 4513 4586 3554 PMC2775948__F2 Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery 367 2192 3934 338 11167 7057 4069 140885 10728 85451 8530 92304 2199 7040 5627 9373 7301 8685 10461 719 5167 10723 10825 1508 2194 2650 51022 10437 9447 PMC2827416__F5 Impact of high dietary protein on lipid metabolism in porcine adipose tissue at body weight 60 kg 7038 4023 355 PMC2829067__F1 Caspase-1 Activation via Rho GTPases: A Common Theme in Mucosal Infections? 5879 998 9447 64127 3553 387 PMC2831127__F7 Proteins Secreted By Embryonic Stem Cells Activate Cardiomyocytes Through Ligand Binding Pathways 3484 4282 3485 3082 2064 5879 387 9475 6774 3726 4613 2353 4209 PMC2834616__F4 EGR3 and miRNAs involving in signaling pathways and regulatory networks in schizophrenia and nervous system 4803 627 3084 2571 1813 1960 7533 2917 1958 4852 596 23237 2557 4804 PMC2850885__F7 Proposed model of a EGFR/Beta-catenin/cyclin D1 signaling pathway in oral cancer 1950 999 1956 1499 324 3065 595 PMC2856329__F9 Brx-mediated osmotic stress-activated signaling system and its implications for the immune response 5879 998 10725 4050 3553 PMC2875073__F5 Albumin alters TGFB pathway gene expression 4052 7057 7049 2022 3624 10468 9241 652 7048 7046 6696 860 864 2280 25805 4086 4090 7471 51176 3716 6774 3976 4091 5601 7124 3725 7030 3458 6772 5595 4790 1387 1950 6497 2353 PMC2908542__F8 Sirtuin 3, a New Target of PGC-1A, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis 23410 7350 2876 6648 PMC2919048__F7 Comparative Analysis of Extra-Embryonic Endoderm Cell Lines 4090 4086 3458 9978 6500 7057 64750 57154 4052 7046 6667 7275 1616 9475 387 10468 5308 4838 PMC2919048__F8 Comparative Analysis of Extra-Embryonic Endoderm Cell Lines 2885 3925 4803 627 1956 2002 6722 5894 4342 2316 3725 399967 5058 7186 4485 355 929 4149 1616 23118 10454 51295 51701 2597 PMC2930854__F10 Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development 2044 5266 998 PMC2933905__F2 Distinct functions for TPPII in the nucleus and cytosol 7939 581 6741 472 PMC3000610__F6 Proposed working hypothesis 7099 6497 56848 8877 2973 PMC3003706__F7 Distinct B1 and B3 integrin pathways converge to regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells 961 6714 7204 5879 PMC3020905__F6 Molecular Basis for Vulnerability to Mitochondrial and Oxidative Stress in a Neuroendocrine CRI-G1 Cell Line 468 2512 7314 340451 PMC3032697__F15 Time course changes in cytokine network pathways of lungs from 9 V/null mice 7124 9332 6346 384 4352 4324 PMC3035565__F11 WNKs: atypical protein kinases with pleiotropic actions 65268 65266 5879 387 5058 65125 PMC3073571__F8 Cone-specific Visual Cycle 6121 9227 6120 PMC3079441__F3 Pharmacological activities of cardiotonic steroids such as ouabain 342538 1956 6714 PMC3087601__F1 Cellular and bacterial profiles associated with oral epithelium-microbiota interactions 4193 545 472 9184 4089 6502 5111 1017 1022 8318 990 4661 PMC3089989__F2 Gene expression pattern of the P38 MAPK signaling pathway 92610 7186 9261 7867 4149 PMC3091670__F2 Interferon signalling cascade 3466 7297 6773 10379 4939 6772 5696 4843 3437 8519 3659 3434 6891 4599 4600 PMC3092604__F1 General scheme of the SBP in Tritryps 2531 204219 6611 5091 PMC3148248__F5 TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding 3146 3929 7099 929 114609 4615 51135 5879 3661 PMC3164671__F5 Genome-Wide Identification of Bcl11b Gene Targets Reveals Role in Brain-Derived Neurotrophic Factor Signaling 627 4803 2885 2549 5163 5602 467 PMC3197364__F6 Hypothesized mechanisms for sphingolipids in cardioprotective signaling in response to ischemia or hypoxia 7124 6497 5058 55872 PMC3204078__F5 SHP-1 activation and modulation on ghrelin signaling to Akt 5163 64223 2475 253260 PMC3216677__F1 Proposed estrogen receptor (ER)-activated signaling pathways involved in vasodilation 1950 1956 7018 PMC3233204__F4 DEVELOMENT AND NEUROGENIC POTENTIAL OF MÜLLER GLIAL CELLS IN THE VERTEBRATE RETINA 30062 1950 896 PMC3251736__F2 Ingenuity pathway analysis (IPA) of the EGFR ablation signature with oncogenic (A) and wildtype Ras (B) 4179 4145 3398 7078 3832 2642 23230 6754 27333 25 990 3172 4087 4088 3026 112744 1852 6668 5054 2919 5284 28983 1378 3625 2643 91807 PMC3275548__F3 Liver from Campari tomato treatment 2308 5747 7525 7026 6505 5468 6720 383 3949 3598 6721 230 1869 29109 7124 55599 3709 5925 5076 4087 55212 5967 7046 4190 10211 79023 3172 229 10989 3030 4580 10651 51611 11343 2193 3833 2147 1877 782 22924 324 1499 56172 4005 10982 7157 5142 10460 5916 3558 80324 1723 PMC3279640__F2 Known genes and pathways of the different cell types of the developing testis in mouse (modified from Wainwright and Wilhelm ) 6736 2626 7490 10370 7536 140689 6662 54361 2254 2263 30812 6663 268 8876 50846 5727 3640 4854 3284 3280 PMC3294376__F4 O-linked N-acetylglucosamine (O-GlcNAc) is a nutrient sensor and underlies glucose toxicity 10724 8473 5163 3630 3667 200186 6667 23236 PMC3334466__F1 Duo/Cdc42 pathways 998 5058 3984 PMC3335094__F3 Mechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK Activation 4351 2002 2885 4342 4763 2316 6395 1386 355 1616 4149 4208 929 23118 51295 51701 PMC3343318__F6 PLC signaling in B cells 7099 613 114609 4615 4067 6850 29760 695 6263 6786 PMC3389016__F3 Anti-Obesity Sodium Tungstate Treatment Triggers Axonal and Glial Plasticity in Hypothalamic Feeding Centers 5630 4741 10221 6774 8050 5604 9124 1738 283455 5164 6667 1737 5162 6517 427 10056 6141 25932 60 6206 3241 6222 7417 23237 4504 PMC3393662__F8 Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcERI Aggregation 4067 2534 6850 9846 27040 PMC3432093__F11 Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells 23411 5728 5163 2475 3553 4513 PMC3445581__F2 Transcriptional Differences between Rhesus Embryonic Stem Cells Generated from In Vitro and In Vivo Derived Embryos 7422 4088 4609 2247 10370 6781 6667 4193 4087 4205 4089 6774 1906 6387 PMC3466406__F2 The integrated large-scale logical model 3082 1950 1956 387 6093 6714 4067 2885 5163 5728 545 472 6009 2475 2002 4208 2113 2353 3725 4609 6774 1758 4193 10682 1050 1051 1021 1019 993 7465 595 894 26259 6502 6468 896 1017 6667 3065 898 990 5111 4863 4171 PMC3504424__F4 Tyrosine kinase receptors pathway 1956 2885 5728 5163 6010 4609 2353 3725 6722 1386 PMC3510514__F6 Model for the role of Spartan in DNA damage tolerance 56852 7398 5111 PMC3518582__F1 Wnt Signal Transduction Pathways 1499 4040 4041 4131 6010 324 PMC3539509__F2 TLR4 signaling pathway: TLR4 is localized on cell surface for ligand recognition and activates both MyD88-dependent pathway and TRIF-dependent pathway 7099 4118 4615 51135 23118 10454 7187 3654 7189 29110 3665 3661 PMC3542528__F5 Various subnetworks of signaling molecules that regulate Golgi structure 8525 8394 5290 5728 9685 547 50807 5007 8853 55616 1314 55738 4646 4641 699 5058 5870 22919 23332 6093 1072 3985 64689 5156 2263 7046 7186 836 5871 6789 9344 5894 5609 1844 1848 2122 51701 56940 1850 5534 2872 8569 PMC3544722__F9 Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase 4193 581 572 PMC3545869__F7 Integration of Canonical and Noncanonical Wnt Signaling Pathways Patterns the Neuroectoderm Along the Anterior–Posterior Axis of Sea Urchin Embryos 22943 7471 1499 PMC3562404__F2 Biochemical relationships between the CDP-choline pathway of PtdCho synthesis, the degradation of PtdCho, and general phospholipid metabolism in mammals 55349 847 907 6611 PMC3563611__F8 Candidate miRNAs target genes involved in cell growth, survival, migration, and cell cycle progression 1019 1017 694 29883 7832 3276 3219 5728 867 2885 80243 5163 1384 3611 998 572 PMC3595616__F1 The branched isoprenoid pathway 23269 3652 1717 PMC3609811__F2 Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress 7124 3572 1437 3562 3558 6364 6370 10803 5008 3791 9180 6367 2324 3561 83729 4804 3976 6366 1950 1956 3977 1270 2322 659 4049 3565 7852 650 4050 3578 56832 655 355 6358 1440 958 6368 3952 50615 59067 85480 50604 10344 6846 11009 6347 2056 1896 10913 5617 51561 7173 4352 PMC3674623__F6 Effect of sodium ferulate on caspase cascade apoptosis and IKK/NFKB pathways induced by TNF/TNF receptor 8717 8772 7186 6420 7124 PMC3682205__F3 Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair 5728 5163 4734 7249 7248 6009 2475 PMC3683050__F11 Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle 5896 2885 90459 3725 7124 7186 2645 355 1616 23118 51295 51701 PMC3722174__F8 Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network 3667 5163 6009 207 7248 2308 23411 4899 7019 9215 3091 PMC3735985__F1 Simplified schematic representation of the insulin and TOR signaling pathways as they have been described in mammals and for which orthologous components have been described in D 2885 5728 7249 7248 PMC3743449__F5 Illustration of the hypoxia-inducible factor (HIF) activation pathway, highlighting hydroxylation and acetylation of HIF-1A depending on cellular oxygen tension, that is, normoxia and hypoxia 1950 3481 3479 3553 2475 7428 7039 3082 5228 4282 7018 PMC3774790__F8 Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2 5457 340419 4009 7471 1499 794 7054 5309 PMC3784473__F9 The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites 3988 4553 3652 PMC3789182__F7 Schematic illustrating a model of NA anticancer activity is proposed 7124 1950 3569 5163 3099 7249 7248 PMC3789261__F3 Pathways impinging specifically on glucose-mediated F-actin remodeling in the B cell 998 5058 6844 PMC3814391__F7 DNA end resection 9156 641 5111 1763 5888 545 PMC3840000__F1 A Potential Benefit of Albinism in Astyanax Cavefish: Downregulation of the oca2 Gene Increases Tyrosine and Catecholamine Levels as an Alternative to Melanin Synthesis 283652 1638 7306 PMC3847898__F1 Wnt signaling pathways and the effects in mature synapses 4040 4041 324 5879 387 PMC3856112__F7 Combination of pathway topology and ab initio reconstructed network 7431 8213 60 5757 5723 6899 10875 3242 3910 26574 3777 9354 3485 2992 9656 80004 10244 54505 3431 6750 4637 27129 83892 22872 7169 1466 6888 PMC3879068__F3 Networks showing metabolic pathways differentially modulated between H and L groups 31 2194 55902 79071 8722 10319 338 3240 7069 6319 3709 4359 10598 5593 5999 27087 25780 663 PMC3890531__F4 IGF signaling pathway 3479 2896 6774 572 3480 PMC3890531__F5 VEGF and NOTCH signaling pathways 2638 4851 4854 4853 4099 7422 2321 PMC3890654__F2 Negative regulators of toll-like receptor-4 signaling pathway by Lactobacillus jensenii TL2937 in porcine intestinal epithelial cells and antigen presenting cells 7097 59307 7099 929 4118 257397 3725 2353 7124 PMC3893574__F1 MiRNAs involved in the regulation of the IGF-1/Akt pathway and myostatin signaling 3479 406990 3480 3667 4088 5728 2475 PMC3915522__F5 Ras oncogenes: split personalities 126432 9610 6010 10928 998 PMC3918842__F2 Pathways for the synthesis of phospholipids and their interconnection 5833 10400 5091 5662 PMC3920940__F7 Diagram showing the model proposed for the association of EMT, CSCs and the PI3K/Akt/mTOR signaling pathway in CaP radioresistance and the effect of possible action of BEZ235 on radiosensitivity 2475 999 1000 960 6657 79923 PMC3929501__F1 a) Digrammatic representation of follicle growth from the non-proliferating pool of primordial follicles 5728 5163 7249 7248 6194 PMC4013479__F1 A simplified working model of the c-di-GMP signaling pathway in B 3098 8568 3099 PMC4055761__F3 Chromatin Remodelling Induced by the Freshwater Cyanotoxin Cylindrospermopsin in Human Intestinal Caco-2 Cells 57470 7871 5519 55718 8897 84246 11340 9931 10001 2965 29109 9412 1654 11218 9552 6607 6606 81669 10762 84726 55905 26610 55284 29128 4194 2122 9604 80314 56902 3875 4520 64769 6041 694 80824 PMC4110175__F2 SP600125 and BCI Inhibition in MAPK Signaling Pathway adapted from KEGG 04010 4803 6955 4351 1956 3630 3726 2645 4149 PMC4110175__F5 LDN Inhibition in TGFB Signaling Pathway adapted from KEGG 04350 25805 4090 4086 3458 9978 8454 6500 7046 PMC4123742__F7 Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair 57697 4361 10111 91442 545 55215 22909 3552 2177 146956 641 80198 84464 55120 2067 2187 199990 5888 672 9025 PMC4151463__F9 Function of integrin linked-kinase (ILK) in normal and activated stellate cells–implications for fibrogenesis in wound healing 3611 6010 998 PMC4189469__F1 Schematic illustrating mechanism for expression and function of regulatory genes for development of the oviduct and for development of epithelial-derived ovarian cancer 6317 89778 6696 2 7018 PMC4211382__F3 Summary of intravascular/extravascular Hb/heme clearance and cellular/tissue distribution 4035 3240 9332 PMC4234693__F3 Influence of canonical Wnt signals on the MAPK pathway 89780 2932 1499 388 387 998 324 6662 PMC4316204__F3 Remodelling the extracellular matrix in development and disease 55727 387 999 4314 4313 4323 4041 4015 2255 2263 PMC4316787__F4 Fourth-ranked enriched canonical pathway identified using IPA at 2 hpi – the CD40 signaling pathway 3718 7186 7185 6774 7189 7188 9261 466 2208 3383 4049 PMC4324684__F9 Proposed pathway of cytosolic jadomycin-induced ROS and their metabolism within MCF7 breast cancer cells 1644 6647 57716 PMC4336643__F8 Proposed signaling pathway 85451 3725 7421 PMC4338835__F3 The catecholamine system in health and disease —Relation to tyrosine 3-monooxygenase and other catecholamine-synthesizing enzymes— 6697 7054 1621 5409 PMC4356644__F1 BiP and its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions 6400 6396 64374 PMC4380406__F1 Impact of Host Diet on Wolbachia Titer in Drosophila 6009 4609 7249 7248 PMC4409212__F1 Novel Cancer Chemotherapy Hits by Molecular Topology: Dual Akt and Beta-Catenin Inhibitors 5163 7249 7248 2475 4193 6009 998 572 253260 PMC4411486__F3 Predicted co-regulation of genes in the MAPK signaling pathway targeted by downregulated miRNAs in BAT during torpor 1610 2885 2353 4149 929 23118 100379198 PMC4419223__F2 Role of green tea in cancer prevention through the modulation of genes involved in initiations, promotion, and progression of cancer 5728 4513 596 581 PMC4423646__F1 Ischemia/ reperfusion-induced and sepsis-induced endothelial dysfunction is initiated by increased amounts of reactive oxygen species 3659 3717 6772 581 PMC4440459__F16 Summary of Ingenuity Pathway Analysis (IPA) 1265 7168 6286 5832 203 1803 11025 6772 10592 1611 2317 10051 PMC4445275__F1 Genes involved in the leukocyte transendothelial migration and Toll-like receptor signaling pathways 8772 3929 929 23118 8205 100187907 1513 7006 100124696 7408 367 PMC4471883__F7 TLR4 signalling pathway to alleviate microglial activation 4615 7099 3553 581 596 PMC4472151__F5 Lineage specific differentiation for MSCs in an exquisitely coordinated process with critical regulators and indicators are shown 1950 6469 5741 50964 6608 324 1499 7189 3092 2735 23462 4772 4488 6497 3224 100187907 1610 PMC4488505__F5 Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin 6198 4133 5604 3932 2185 5598 2475 84335 8835 4869 898 1033 660 1017 3725 596 6850 5599 5979 5566 6714 5610 5728 PMC4516574__F5 An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells 3458 3717 7297 6772 8651 6773 8554 10379 581 5696 3437 4938 8519 3659 3716 3434 PMC4528364__F8 Conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy 9776 83734 167227 10533 64422 22863 PMC4546272__F3 Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma 25859 5347 983 324 11186 1017 991 993 1431 9184 6502 PMC4553214__F2 IPA analysis based hnRNPD networks in oral cancer 2475 1356 2000 6187 6188 6217 6208 6175 6128 26986 26523 1654 51493 10342 6137 27161 192669 4637 1994 10492 6625 4691 10657 4841 23321 7536 8570 8148 3609 10432 3192 3184 2521 6311 3178 7073 27316 4904 6601 4670 3191 3183 6634 10236 3182 3189 8289 10949 6605 3185 3187 3190 2547 PMC4591129__F3 Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle 335 5360 6319 4023 7350 3611 7316 364 PMC4602327__F1 Major pathways of apoptosis 4170 637 7186 572 581 735 730 729 718 8717 8772 PMC4614078__F9 Updated model showing the role of AMPK-HDAC5 in HIF-1 activation as a response to hypoxia 10014 3652 7428 PMC4642978__F1 Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response 6289 5950 4015 7441 100289462 2243 362 PMC4642978__F2 Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response 5806 6289 5950 4015 2243 362 4093 1356 PMC4645220__F13 Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway 3984 3985 4313 4318 PMC4649622__F4 Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice 5914 3716 3717 7297 8651 8554 581 5696 10379 3659 4599 3430 PMC4649622__F5 Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice 8772 8717 7186 1616 29110 331 637 56616 27429 54205 329 4671 4000 6709 3984 22985 2620 56829 355 397 PMC4669899__F2 Simplified outline of Insulin and AA/TOR signaling pathways 7248 7249 5728 5163 6009 PMC4687939__F6 Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism 9242 1499 650 6932 1051 4088 7494 406947 6662 1959 51274 55294 1487 1488 1879 688 4331 9869 2303 10682 8864 5947 3091 23175 4776 26580 3952 2167 10555 5346 4023 9474 10628 10533 PMC4690264__F1 Type I IFN signaling pathway and transcriptional changes of selected ISGs in the spinal cord of TMEV- compared to mock-infected SJL/J mice 9636 4600 4599 PMC4714567__F5 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs 196 100188857 1316 PMC4733656__F5 The Elizabeth River Story: A Case Study in Evolutionary Toxicology 196 405 1545 57491 PMC4766410__F5 Extracellular calcium-sensing receptor regulates human fetal lung development via CFTR 1080 846 1179 1181 PMC4788817__F6 Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia 1392 7099 1394 361 PMC4790729__F1 Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders 3667 2885 6654 5728 5894 2475 1977 2002 PMC4790729__F2 Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders 3479 2885 572 PMC4795655__F4 De Novo Transcriptome Analysis Provides Insights into Immune Related Genes and the RIG-I-Like Receptor Signaling Pathway in the Freshwater Planarian (Dugesia japonica) 23586 7186 7189 7187 29110 3661 3665 PMC4821805__F1 Evolution of haem biosynthetic and degradative pathways 3145 7390 7389 1371 5498 2235 PMC4848680__F4 Eicosanoid synthesis pathways: Arachidonic acid is a polyunsaturated fatty acid that is released from the cellular membranes by cytoplasmatic phospholipase A2 (PLA2) 4015 4512 4050 PMC4878077__F5 Shows Jak/stat pathway analysis for the TO-VS-IFN/SAV3 and TO-VS-SAV3 using the KEGG pathway software analysis 867 2056 8027 3558 3562 5292 3569 PMC4915479__F4 Major TGFB signaling pathways in vascular cells 6010 2022 10716 2885 7189 64750 10276 2932 993 1017 1386 51176 PMC4963952__F5 Regulation of genes of Cell Cycle pathway during senescence induction in HFF strains 5591 9126 8556 8318 7272 7042 5347 995 1030 991 891 4118 9184 5111 1111 993 10459 1017 701 5933 890 983 990 23594 8317 10926 9088 PMC4963952__F6 Regulation of genes of cell cycle pathway during senescence induction in MRC-5 strains 113130 10912 7042 9088 1870 991 9184 7272 5111 23594 4171 4172 4175 1017 1022 4609 4661 4999 94233 PMC4989048__F3 PhenomeExpress analysis 10926 6275 84515 11130 701 55165 6623 253714 79673 10687 4172 10428 8091 983 4173 6638 10610 26013 4088 23277 1033 4430 55146 10904 2099 7153 80195 467 2274 57826 2535 79784 862 4920 7474 8321 57541 547 2113 4094 6662 2114 571 7293 54101 7185 51144 51330 33 79716 27352 2697 8742 1843 11270 4982 4942 9332 5600 11221 5328 8793 8870 56034 5054 5327 5329 10516 4053 1311 1298 7297 53353 6649 2191 1280 7045 6678 1277 54760 1294 3486 3914 3481 960 3489 1296 3965 1462 3118 9510 3964 6403 3700 710 6364 1404 PMC5011625__F5 Endothelial Mechanosignaling: Does One Sensor Fit All? 3383 7412 387 1003 7074 5879 PMC5062167__F8 Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model 4550 6053 6055 5763 PMC5063567__F2 The Kynurenine Pathway Is a Double-Edged Sword in Immune-Privileged Sites and in Cancer: Implications for Immunotherapy 4282 920 196 7008 5728 PMC5105076__F8 Qishen granules inhibit myocardial inflammation injury through regulating arachidonic acid metabolism 4512 4513 6774 PMC5123368__F7 Schematic presentation shows the Adiponectin signaling pathway in neuron under normal (left) and disease (right) conditions 3667 351 3553 PMC5153247__F8 Schematic diagram of Akt/Id2 signaling pathway in the neuron 999 761 847 3398 PMC5164846__F2 Fine-tuning vascular fate during endothelial-mesenchymal transition 7048 7046 10818 4087 4088 PMC5228322__F1 Illustration of the Wnt signaling pathways 6010 1499 51701 PMC5250671__F1 Oncogenic pathways in glioma and possibilities for pharmacological interventions, relevant for the models described in this article 2885 5728 3417 2475 4193 5925 1019 PMC5259746__F3 Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway 3479 3480 355 637 572 581 596 7124 2885 7186 9049 80153 6733 387 7054 PMC5310915__F12 Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken 5360 4023 4312 7350 3611 7316 PMC5325323__F3 Neural tube closure: cellular, molecular and biomechanical mechanisms 1364 79977 999 5879 650 6469 3240 4090 4086 387 PMC5331536__F8 LSS improves cognitive function and prevents neuronal injury of AD rats via inhibiting the neuronal apoptosis signaling pathway 4047 572 581 PMC5344275__F1 Schematic structures of HGF (A) and Met (B) 2885 2549 6774 PMC5345234__F3 Connectivity of genes that were upregulated in astrocytes by Meth 1063 2065 2035 1360 3290 5566 2742 5669 5062 58513 3561 4481 11250 23305 5771 8547 1361 881 9674 2213 11055 23049 9794 3627 23469 7253 717 26191 2784 23650 81697 644 5912 3423 11063 6373 5733 3458 5077 5729 3054 2798 8942 6375 8496 2057 3898 186 7629 89795 5781 5457 11095 10172 1740 11030 783 4322 3480 PMC5345234__F9 IL2RG-centered gene subnetwork 7409 5062 57097 7317 920 5549 6891 9968 1441 1740 6693 5972 2065 680 5781 8837 5143 3561 26191 59067 5771 3054 2057 9830 5996 83637 3480 783 51635 PMC5479307__F4 There are similarities and significant differences in light and dopamine mediated phase regulation of the retinal clock in Xenopus leavis driving melatonin release and that in mice driving PER2∷luc expression 8864 94233 221391 780 PMC5515402__F3 Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids 51182 28962 2597 83942 3326 2316 3645 340359 433 10420 PMC5516996__F3 Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder 1017 472 545 355 637 64065 7249 64326 4193 6477 4609 PMC5516996__F5 Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder 9126 4089 699 9184 5111 1017 1022 4661 1874 8317 4397 4999 23595 991 993 8318 6502 999 10926 4998 5000 23594 PMC5541046__F7 Working model of the EphA4–ephexin1 signaling pathway and BDNF-TrkB signaling pathway in the model of depression 627 2043 1020 2534 PMC5552148__F2 Generation of ROS as a result of incident radiation affecting the mitochondrion.Notes: ROS have been shown to form oxidative DNA adducts, such as 8-OHdG, which in turn can lead to base modifications and transversions, such as GC to TA 4513 472 545 PMC5562708__F7 IRS4 interferes with BMP signal transduction and functions as a novel regulator of BMP signalling and myogenesis 4090 4086 4089 8471 2475 2932 3397 PMC5578405__F10 Schematic summary of the possible link between IGF-1R signaling, synaptic changes, neurotransmitter function and inflammatory response 3479 3480 2475 3146 9456 1103 7099 PMC5587765__F3 IPA canonical pathway analysis and molecular activity of genes regulated by p53 in response to OT in differentiated SH-SY5Y cells 7124 355 4217 841 637 581 572 2021 27429 54205 56616 317 2619 329 842 1647 836 1612 1676 840 6093 3397 1649 5625 PMC5595712__F3 A maize amino acids network involving key genes identified in this study by GWAS 3712 4826 51083 PMC5618489__F7 Dynmics of starch biosynthetic pathway during development stages of pericarp and endosperm 5167 2875 1611 PMC5626732__F8 Signalling disruptions in Depdc5 FS/FS mice 3667 8131 10641 9681 7249 7248 PMC5655190__F14 Sodium fluoride induces renal inflammatory responses by activating NFKB signaling pathway and reducing anti-inflammatory cytokine expression in mice 3553 3586 3565 PMC5662495__F2 Mitochondrial Ribosomes in Cancer 7124 8772 637 581 331 PMC5676474__F7 Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on In Vitro Produced Embryos 1649 4780 1647 6647 5052 847 2876 2879 6648 3320 3303 3329 9643 PMC5711377__F3 Pathview () plot of the KEGG () pathway showing the Cell mitotic cycle ('HSA 04110') superimposed with RNA-seq expression data corresponding to the log2 -transformed fold change in expression of cell cycle transcripts from HIOs microinjected with E 7465 7529 472 5111 5591 902 1874 890 8318 PMC5719347__F7 Signalling pathways associated with PRDXs and hypothetical illustration of PRDXs in mouse spermatozoa 1956 355 2950 2745 5052 4293 7001 140809 9588 4842 10935 7263 PMC5722193__F2 Acute metabolic effects of AMPK activation 2475 23216 5208 7249 5209 948 PMC5742324__F1 Glucose and glutamine catabolism provide tumor cells with biosynthetic precursors 5163 51660 2744 3939 3945 3107 PMC5759779__F3 Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer's disease 5338 4512 5159 3479 PMC5777730__F8 Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer 2997 10401 10254 4296 5771 3716 5777 6772 6722 2273 5781 207 3265 10379 5894 1387 387 2885 8660 2475 23533 6689 2780 653361 6134 2670 1811 3190 PMC5779628__F11 Excitation–transcription coupling responsible for maladaptive metabolic and antioxidant remodeling in HF 5468 6262 627 90550 4899 6256 5465 7019 6648 23530 3418 7054 PMC5796046__F3 PB1-F2 virulence 581 7189 57506 7186 7187 10241 29110 3665 3661 114548 3553 PMC5799271__F2 TLR4 signaling pathways 7099 4615 3654 51135 29110 7189 3661 PMC5804041__F2 PPARA-RXR signaling pathway 4905 2885 3717 8195 3667 5465 6258 5468 6256 5467 6955 602 8431 26038 100187907 9575 30 126669 3725 7025 2194 PMC5816341__F1 Schematic diagram of the three pathways of the complement system, highlighting the upregulator (properdin) and downregulator (factor H) of the alternative pathway 718 727 720 729 115939 55720 90121 717 716 1431 PMC5826526__F5 Eukaryotic initiation factor 2 (eIF2) signaling pathway 3643 2885 83939 2001 1983 1977 1999 2147 80237 PMC5849167__F5 Ang-2 up-regulating EMT and facilitating lung cancer metastasis 7428 2023 2597 133 2056 7431 999 2821 5230 4843 3481 7039 2475 PMC5857600__F5 Alterations in the mammalian Hippo signaling pathway alter FLNA phosphorylation 79633 8642 4485 9113 26524 81532 PMC5869742__F5 Involvement of proteins found in the yolk sac fluid and the uterine fluid of pregnant mares in GO terms and pathways representing embryo-maternal interaction 6654 3988 3329 2268 57447 8570 4067 8161 8531 6122 6187 5345 208 7430 210 5552 27316 3977 6868 1025 2324 4282 10094 72 7422 345651 3263 11140 59 10109 2261 102 3148 PMC5869742__F7 Inhibitors of prostaglandin synthesis in uterine fluid of pregnant mares 301 240 4512 2950 22949 5226 5228 4050 PMC5879898__F6 MAPK signaling pathway and the JAK-ATAT signaling pathway 790953 1956 2056 8027 5292 3569 351 PMC5897396__F7 The proposed PTN pro-migratory signaling pathway that leads to CDK5 activation in human endothelial cells 5764 1020 5879 PMC5900707__F2 Activation of TNFR1 may promote multiple alternative signaling pathways, including the activation of NFKB, RIPK1-independent apoptosis (RIA), RDA, and necroptosis 7124 23118 257397 57162 9825 1540 8772 8737 11035 7186 7188 8717 PMC5951999__F7 Mechanism underlying how BYD exerts a cardioprotective effect 596 581 9261 1410 PMC5964135__F2 Proposed signaling cascades recruited in the setting of remote ischemic conditioning based on available data 367 847 572 581 PMC5979320__F2 BCAAs balance and its multiple roles via PI3K-AKT-mTOR signaling pathway 64798 9776 2475 6009 9675 253260 3667 PMC5983834__F4 PI3K-AKT signaling pathway 1977 7249 6009 2475 1975 5879 6850 613 930 5934 5728 572 6256 4193 2885 4609 595 PMC5986551__F5 Network analysis of differentially expressed genes in glioma cells exposed to exosomes 1437 114898 1038 6347 11037 644168 1440 3760 3553 60676 343450 3576 378938 6375 PMC5991297__F1 AGE-RAGE signaling can activate ERK1/2 signaling 6285 3146 10725 7124 3725 2113 PMC5996875__F4 Fibroblast growth factor receptors and genes that are involved in FGF pathway were analyzed by IPA in KC iPSC compared with normal iPSC 2246 2260 53834 3082 2885 3265 5335 3708 6774 9261 PMC6008200__F7 Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research 1398 1399 10818 5607 5598 468 10603 4133 2885 9261 4803 627 2549 4794 4792 4793 5170 4908 2309 5580 5335 5336 572 5664 5663 2932 91860 810 163688 51806 387 7531 581 7189 10782 998 4214 6272 4397 5879 PMC6034273__F10 Interaction among MCP-1/CCR2 signaling, TLR4, and GSK3B in ethanol-induced neuroinflammation 729230 7099 4615 2932 3569 PMC6078908__F6 Conceptual Circuit Model for How External Warming Induces and Links Sleep and Body CoolingSkin warming activates a pathway that runs through the spinal cord and is relayed by glutamatergic neurons in the lateral parabrachial nucleus [, , ] 4353 4842 4025 PMC6105390__F4 Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model 654 3627 6352 2706 6561 5243 7436 3133 11343 10162 3117 200931 2012 6581 84830 9429 343 54566 8682 4547 2168 788 1491 224 384 5166 11001 5825 6319 3001 34 84649 1580 641371 8800 1374 847 1376 9588 8313 3030 1733 116362 5836 1622 2908 3172 5467 5465 5468 9971 10397 10769 64332 88 9915 8553 117145 10891 23205 1536 3929 1811 23705 5066 57552 3554 66002 6715 79152 33 6505 9962 957 6550 5604 6752 2770 3459 51365 1562 PMC6109777__F4 Cellular protection mechanism conferred by Nrf2-ARE pathway after intracerebral hemorrhage (ICH) 6648 571 9817 8452 4094 1728 PMC6114981__F7 FABP5-mediated transcriptional controlling network of mitochondrial functions in PCa cells 2171 9927 50 2271 PMC6120108__F2 The BDNF/ TrkB signalling in normal and glaucomatous conditions 627 2885 5335 22926 83939 468 PMC6151665__F8 Mechanism of emodin to inhibit IAV replication and IAV viral pneumonia 7099 7189 1728 2729 847 PMC6156233__F6 Graphical Abstract 2638 7099 3606 3586 6120 PMC6196465__F3 Milk protein synthesis pathway in porcine mammary gland 3906 107966124 7462 PMC6196465__F5 Lipid synthesis pathway in porcine mammary gland 948 55902 79611 2181 2170 2194 31 3992 9415 57678 6319 9663 123 440503 8694 7498 11120 64834 PMC6202086__F4 The mechanisms involved in the maintenance of b[Ca2+]i 7222 6262 4827 3708 PMC6249275__F3 Keap1-dependent and Keap1-independent mediated Nrf2 signaling 9978 9817 2932 196 406983 405 4094 PMC6278600__F1 Postulated cellular mechanisms of 20-HETE bioactions in the blood vessel wall 10936 1956 28964 387 1636 3569 1977 PMC6280103__F5 Cholesterol biosynthetic pathway and relative expression changes for genes encoding related enzymes 38 3157 3156 4598 10654 4597 3422 2224 2222 6713 10682 6307 7108 51478 50814 6309 1717 PMC6316730__F4 KEGG pathway analysis of the cell cycle in GNP-treated cells 10274 10735 4087 4088 4089 4193 6502 9184 991 699 5111 993 1017 1022 990 4661 999 1874 1869 10926 324 8318 PMC6322547__F1 Transcriptomic analysis of axon guidance signaling pathways in liver fibrogenesis 387 1630 998 4750 2534 5998 6387 6092 6585 9353 29984 27289 2242 5810 8482 5727 6469 6608 3611 91653 6259 655 151449 PMC6329348__F3 Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue 60412 6788 6790 7415 91754 2946 983 671 7157 3939 26059 10963 4175 1164 51129 1363 10438 91768 252969 11072 4060 51752 8131 1736 84133 94241 4035 54407 5683 7450 140 824 2984 831 1015 51684 5978 84525 PMC6362084__F5 Activated TLR4 signal inhibited by neurosteroids 7099 3146 4615 7189 PMC6403405__F8 Functional mechanisms of COL2A1 on the BMP-SMAD1 pathway 3688 3687 659 4086 4089 PMC6410520__F1 Microbial-based production of nutraceuticals from simple carbon sources 3652 412 443 PMC6422901__F2 Schematic for arachidonic acid (AA) pathway: phospholipids from the plasma membrane are mobilized and converted to AA by phospholipase A2 (PLA2) enzyme activity 4513 4512 4056 4048 4050 100188011 5228 PMC6422901__F3 EP receptors and their downstream signaling: PGE2 binds to its cognate receptors, the E-series of prostaglandin receptors (EP1–EP4) on the plasma membrane and nuclear membrane 6714 1499 2303 7018 PMC6422901__F4 Combating inflammation promoted by KSHV infection: KSHV infection promotes pro-inflammatory lipid mediators of arachidonic acid pathway and the enzymes involved in their synthesis 4313 7422 7424 6714 PMC6423962__F1 Expanded cholesterol synthesis pathway diagram 3156 6713 4047 1718 100188864 7108 3930 50814 51478 10682 6309 1717 PMC6467965__F2 Schematic presentation of the cytotoxic pathways, induced in cancer cells by the complement C5b-9, the counteractive cellular resistance mechanisms, and postulated approaches to overcome this cancer evasion 718 1604 4179 966 11035 197259 637 PMC6480527__F10 Model of the Nrf2-mediated oxidative stress response pathway in bovine granulosa cells under moderate oxidative stress conditions and under antioxidant (quercetin) supplementation 9817 100126333 4094 1728 5052 847 PMC6482944__F2 Molecular regulation of PFGA in Mice 9365 652 655 2661 2668 3815 5728 5163 3603 3976 6009 2475 7248 7249 268 6387 PMC6487307__F1 Polyamine metabolic pathway 51582 85413 55256 196743 6723 6520 6303 262 6611 54498 PMC6487307__F12 Schematic summarizing the “reprogramming” of polyamine metabolism by iron-depletion in: (A) SK-Mel-28 human melanoma and (B) MCF-7 human breast cancer cells 6303 55256 196743 51582 262 54498 6723 6520 85413 6611 1878 8178 PMC6561916__F4 Stem cell-related signaling pathways in miR-25 overexpressing LX-2 cells 5581 4854 51715 5328 4851 10023 2619 6387 26190 23385 55534 4311 5664 960 1000 998 5230 1277 6868 3516 5584 6608 3725 27148 103 9794 1488 5879 2932 4609 387 4089 84441 1387 51701 203068 5567 2260 1457 894 1453 2735 3065 3251 1857 5467 5601 1487 53944 5515 8061 896 5590 5045 196403 2736 55851 8945 3955 5583 5580 7473 9253 113878 1455 10683 2246 5529 151636 8850 3949 5015 5527 9612 898 1454 22938 8312 PMC6562892__F2 PPAR (peroxisome proliferator-activated receptor) signaling pathway enriched of differentially expressed genes (DEGs) in the jejunum of broiler chickens 948 335 10999 5360 376497 4023 1962 6342 1376 33 7350 7316 5105 3611 PMC6563994__F6 Social status regulates the hepatic miRNAome in rainbow trout: Implications for posttranscriptional regulation of metabolic pathways 255061 3739 2026 2821 3098 669 5230 2023 2597 7167 80315 5213 23378 5214 4624 5160 468 5315 5105 3948 5279 51660 3030 5091 PMC6613612__F7 Differentially expressed genes in p53 signaling pathway 472 545 355 637 581 1869 4609 842 836 10572 94005 4193 64065 84883 7249 5728 6477 3486 64326 PMC6627039__F1 Viral appropriation of cellular nucleocytoplasmic transport 3661 6772 23636 4928 9972 10763 55706 9631 PMC6639052__F2 Proposed role of NEDD4 in IGF-1R signaling 3479 3480 3667 5728 2887 4734 PMC6657359__F7 Model for Hand2-Dependent Mechanisms That Regulate iPM Formation by GHMT 1482 6474 3670 9096 9464 6926 10021 PMC6664006__F8 Proposed model to explain how COX-2 might be essential in the stimulatory pathway for ROS production and increased expression of profibrotic genes mediated by PRR activation 50507 4087 4088 PMC6678287__F6 Simplified pathways showing the effect of F-6 cell proliferation and death 581 2475 840 842 836 PMC6686084__F1 An example of cellular nutrient–gene interaction mechanisms 2645 355 6319 PMC6691693__F2 Differentially expressed genes involved in cell cycle pathway 9126 4089 4193 6502 991 699 9184 5111 993 1021 1019 1017 1022 999 8318 4661 1869 1874 10926 4999 23594 23595 8317 PMC6695051__F4 Result of the exploration of HTR1A functions involved in biological process pathways using the STRING database (http://string-db.org/newstring) 3350 253260 4846 2932 2475 2309 207 4193 2308 5728 3611 PMC6695471__F1 Transcriptional regulation of carotenoid biosynthesis pathway (CBP) genes in photosynthetic tissues 64326 55070 1642 80119 PMC6710759__F1 Schematic KEGG map representations of signaling pathways involved in Alzheimer's disease (a), Parkinson's disease (b), and amyotrophic lateral sclerosis (c) 351 23385 3416 4023 572 637 836 842 317 6622 7124 2932 840 1616 4747 4741 4744 5630 9973 847 348 22926 3613 PMC6719163__F6 Nobiletin-induced apoptotic pathway in bladder cancer cells 572 581 811 83939 468 2475 PMC6759601__F5 Schematic overview of gene expression regulation of fatty acid oxidation and tricarboxylic acid (TCA) cycle in tPVAT and IAT 2170 7038 788 1431 37 33 35 34 4191 4190 130752 55825 2271 6389 3030 3033 644096 54949 6390 6391 6392 8803 4967 1738 8802 8801 27040 1962 3420 3421 PMC6769485__F2 Anti-apoptotic and cell survival activities of some HSPs in cancer 581 355 54623 PMC6769485__F3 HSP90 functions as a mediator of many oncogenic and signaling pathways 581 596 6714 8772 5163 2932 998 324 1499 6774 367 999 1956 355 PMC6769509__F3 Flavonoids as anti-diabetic agents: Modes of Action 100187761 2539 7422 3492 PMC6787556__F4 NAD+ Depletion and Impaired Mitophagy Are Pivotal Events in Common Neurodegenerative Diseases 23057 952 142 23098 7808 1020 2597 627 23621 2521 10135 1636 3418 PMC6801086__F8 Base excision repair pathway, homologous recombination pathway, and how BER intermediates may lead to HR 9156 672 675 5888 5423 11284 353497 5426 51426 PMC6813227__F6 Signaling pathways 3479 3480 8660 7046 5170 4087 4089 7248 7249 22933 23411 6009 57521 2475 6198 1978 PMC6899468__F5 Schematic diagram showing the PST inhibition of gluconeogenesis in hepatocytes 5331 3667 5163 717 2638 5105 PMC6902869__F1 Tumor-targeting bacteria engineered to fight cancer 929 7099 7100 3458 3553 PMC6908786__F4 Different signaling pathways triggered by different iNOS inducers that regulate iNOS expression (left: activation of NFKB pathway; right: activation of JAK/STAT-1A pathway) 7099 4615 7189 PMC6923311__F1 DSB repair pathways.1017In the C-NHEJ pathway, DSB formation induces binding to broken ends by KU70/80 heterodimers that subsequently recruit the DNA damage response kinase (DDK) complex such as DNA-PKcs in mammals 3014 55183 672 472 9156 1763 10721 2237 2638 PMC6953027__F2 Signaling and gene regulatory networks in pluripotent (naїve and primed) and teratocarcinoma stem cells 79923 6657 10365 3976 4838 3082 627 1950 6997 3977 4091 4092 1499 1852 914 4149 2103 1019 9314 3397 1601 1045 3398 6929 27022 145258 5080 PMC6985208__F3 Signaling pathways associated with highly differentiated proteins in Y spermatozoa 832 2947 64446 8050 347733 114327 51807 PMC7057764__F1 Impact of lactic acid on tumor angiogenesis 8205 383 4318 PMC7072820__F7 MiR-202-5p-mediated SF1 regulation of the canonical TGFB signaling pathway in GCs 7046 7048 4088 4089 4087 7536 1588 PMC7177420__F1 Harmful effects and mechanisms of alcohol 6347 3553 4513 2670 PMC7191626__F1 Enzymatic cascade involving the renin-angiotensin system, key receptor systems, and biological effects 59272 1636 367 PMC7234920__F2 The compartmentalization and interplay between the extracellular and intracellular pathways for (acyl-)CoA degradation and intracellular CoA synthesis 284439 8034 10478 8875 8876 53354 80025 79717 55229 60490 79646 56342 7939 80347 283927 390916 254552 10005 10380 PMC7264106__F1 TNFR1 and TNFR2 signaling pathway 8717 197259 7186 8772 23118 PMC7289953__F1 Mechanisms underlying experimental liver transplant tolerance 942 941 7099 920 9242 PMC7312732__F6 Activation of the TRPV1 ligand-gated ion channel and subsequent [Ca2+]i and protein signaling influence the balance between proliferation and apoptosis 7442 1956 637 472 4803 5879 5163 7494 22926 468 85451 PMC7333668__F1 Myosin light-chain phosphatase (MLCP) through regulation of myosin phosphatase target subunit 1 (MYPT1) 5480 8407 5053 3611 PMC7339444__F8 Pcdh8 in Wnt/PCP signaling in Xenopus 5100 23002 5879 387 PMC7343830__F6 Proposed regulatory mechanisms of blood circulation for hypoxic adaptation in Tibetan chickens 2475 3099 5476 57486 23236 64223 8650 7410 3315 2013 6789 350 845 59272 83988 183 PMC7379200__F3 MicroRNA (miRNA) regulation in the maintenance of male hormonal balance 6935 2734 5451 4211 442909 406959 5728 6770 19 407054 100126303 100126306 100126342 100313837 1823 2060 6047 367 100126354 554213 693122 693219 100616240 406991 406906 2737 PMC7461546__F5 NME protein-histidine kinase functions 4830 56302 29085 1956 4831 8802 230 47 64077 8844 PMC7508399__F5 Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies 1431 942 941 940 6256 4209 PMC7600476__F3 The major cell signaling pathways by resveratrol and/or curcumin in melanoma 1499 673 596 581 5728 4193 2475 6774 PMC7664177__F2 Canonical Pathway of NFKB which represents the pro-inflammatory response, and Keap-Nrf2-ARE Pathway which represents anti-inflammatory response 7124 9817 3550 4094 4513 PMC7744373__F5 Differentially phosphorylated protein Pathway enrichment analysis 3630 2147 324 6010 5829 7414 7408 3611 5728 1398 126669 572 PMC7789255__F1 Possible paracrine mechanisms controlling self-renewal of spermatogonia in juvenile testis 9227 389421 7704 157506 51109 9985 5979 2668 402381 54937 1592 56603 340665 1381 1382 PMC7795031__F1 Shows how AhR ligands, such as air pollutants, FICZ, TCDD and kynurenine, including tumour derived, activate the AhR to modulate mitochondrial metabolism, partly via the regulation of the melatonergic pathway 15 438 5132 5163 7808 406 196 4513 6648 PMC7809845__F4 Prolactin signaling pathway (KEGG ID: hsa04917) 6714 2885 3845 2353 25759 10000 2932 1154 5617 5970 7054 5618 2645 894 PMC7816800__F4 Functional interactions between genes under positive selection in the insulin signaling pathway (ingenuity pathway analysis, IPA) 6844 867 1398 2549 5728 9021 2885 572 2887 47 3991 PMC7816800__F7 Functional interactions between genes under positive selection in the mTOR signaling pathway (ingenuity pathway analysis, IPA) 3643 3667 7249 5091 2475 6009 1977 6010 9776 1999 1975 PMC7829348__F2 Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions 7099 3929 929 4615 114609 3654 51135 7189 7187 23118 257397 29110 3661 PMC7829553__F1 Currently known CoA-dependent enzymatic reactions and transporters in human peroxisomes 100049579 54677 1384 30 3929 1628 51 8309 8443 215 225 5825 283927 390916 570 5827 PMC7865717__F4 Proposed model of resveratrol action during oxidative stress in glaucoma 6120 23411 7019 PMC7905385__F1b Immune response, immunopathology, and mechanism of action of immunotherapeutics for SARS-CoV-2 infection (intracellular) 7113 22848 7098 51284 54106 3553 759 2920 4513 PMC7924210__F2 Simplified mechanism of the classical endocannabinoid ligand signaling pathway 222236 2166 26191 PMC7926305__F4 Common proteins identified in the three replicates of canine in vitro oviductal cell-derived extracellular vesicles that participate in the canonical pathway (CP) ERK/MAPK signaling 2885 1398 6714 5829 1793 4342 7444 572 1977 2002 4772 6722 PMC7927090__F2 Summary of key pathways regulated by H2S donors in the treatment of CVDs 759 7186 7189 5163 6446 3717 23411 468 6774 2475 PMC8005123__F2 Molecular pathways of SMC-mediated migration and proliferation 2638 1524 3280 54626 388585 PMC8009801__F3 Identification of small molecules targeting the Hippo-TAZ/YAP pathway 4485 685 860 9113 374 4609 PMC8025927__F1 Schematic model depicting the mechanisms of meiotic arrest 2827 7048 4882 23028 4088 4880 100187761 367 2492 983 324 9133 891 PMC8037405__F2 Key regulators and genetic pathways of phase transition from SAM to IM in cereal crops 30846 10938 2221 3397 PMC8054134__F4 Proline generates GSH and NADPH to counter oxidative stress 10873 5625 3418 3417 4199 PMC8056183__F1 Indirect effects of viruses on the apoptotic pathway through deregulation of cellular miRNAsmiR-2861 increased the apoptosis of cervical cancer cells through the PI3K/AKT pathway by targeting EGFR 1786 4087 4088 8772 8717 7186 6714 4092 64750 100422910 5728 4089 572 581 596 PMC8056183__F2 Cell death pathways and viruses: Role of microRNAs 100126297 331 2475 64798 64223 8408 PMC8105388__F3 Transcriptome of wild-type and immortalized corneal epithelial cells 4999 23594 6502 1874 4172 4176 4089 1017 4193 1022 8318 8317 8900 545 4357 9184 9126 10274 10735 324 991 8697 25847 51434 1690 999 PMC8143046__F2 Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells 3092 1889 81609 6642 26060 PMC8144624__F5 Health monitoring in birds using bio-loggers and whole blood transcriptomics 27152 1540 26007 9140 9474 79671 7975 1147 3627 8168 100187761 PMC8165240__F1 Cannabinoid Signaling in Auditory Function and Development 63874 51573 26191 2166 4513 747 221955 57406 26090 2147 PMC8201398__F2 Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights 114548 6772 7097 7099 50943 4583 PMC8210594__F1 Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease 115004 50943 861 3815 940 1493 8870 PMC8217358__F1 Gene- and RNAi-Activated Scaffolds for Bone Tissue Engineering: Current Progress and Future Directions 4090 4086 4340 860 10454 1749 PMC8226833__F3 Resveratrol Production in Yeast Hosts: Current Status and Perspectives 7086 2271 412 PMC8231864__F1 Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles 5728 5163 100187761 PMC8247573__F1 Arbuscular Mycorrhiza-Mediated Regulation of Polyamines and Aquaporins During Abiotic Stress: Deep Insights on the Recondite Players 847 1610 4602 PMC8258675__F1 Mechanisms associated with the depigmentation of brown eggshells: a review 9429 28982 210 7390 7389 1371 10058 292 2235 PMC8282456__F3 Recent Advances in Heterologous Synthesis Paving Way for Future Green-Modular Bioindustries: A Review With Special Reference to Isoflavonoids 650 4313 4318 2309 84803 4547 596 581 PMC8304139__F3 NFKB—An Important Player in Xenoestrogen Signaling in Immune Cells 613 6850 8915 10892 5971 4050 PMC8333067__F6 Pattern recognition receptors in health and diseases 7187 10010 3661 57506 29110 7099 4615 7098 PMC8391638__F2 Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research 387 6010 1003 PMC8417791__F1 An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update 1636 59272 367 PMC8431670__F3 UBL5/Hub1: An Atypical Ubiquitin-Like Protein with a Typical Role as a Stress-Responsive Regulator 10413 55215 2177 PMC8431791__F2 Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases 6010 998 2002 PMC8508937__F3 ERB Regulation of Gonadotropin Responses during Folliculogenesis 2492 26060 1588 3973 PMC8516344__F4 Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation 3550 10142 1283 PMC8530467__F1 Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? 10379 6772 6773 59272 3661 3663 7113 10392 57506 29110 PMC8534790__F5 Review of Bioeffects of Static Magnetic Fields on the Oral Tissue-Derived Cells and Its Application in Regenerative Medicine 5137 1499 860 1277 4772 100187907 PMC8539471__F3 Controversial Role of Adiponectin in Appetite Regulation of Animals 23237 51094 5443 4852 PMC8578498__F4 VGF as a biomarker and therapeutic target in neurodegenerative and psychiatric diseases 2475 7425 627 6853 PMC8583510__F5 Mitochondria as a Cellular Hub in Infection and Inflammation 3606 79792 7096 7097 7099 4485 114548 7098 51311 54106 51284 4615 79132 7189 51295 3665 3661 57506 7187 10010 PMC8589993__F5 Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer 7124 7096 7097 929 7099 1839 1956 23118 257397 10454 7185 7186 7187 5879 114609 7189 5058 5970 4792 4615 8772 1270 4803 1950 3725 2353 836 142 1435 1437 3600 602 5328 4314 4323 4318 6401 7412 5743 3606 598 331 596 PMC8601173__F1 Metabolic engineering of microorganisms for the production of multifunctional non‐protein amino acids: G‐aminobutyric acid and D‐aminolevulinic acid 4118 5805 727 11113 847 2549 130749 PMC8634714__F2 Latest Developments in Immunomodulation of Mesenchymal Stem Cells in the Treatment of Intrauterine Adhesions, Both Allogeneic and Autologous 64806 85480 90865 8717 7186 PMC8642280__F4 How alcohol affects insulin‐like growth factor‐1's influences on the onset of puberty: A critical review 3667 3479 6009 7249 2475 6247 PMC8651430__F2 Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It 1636 100187907 59272 PMC8657749__F1 Phytosterols in Seaweeds: An Overview on Biosynthesis to Biomedical Applications 9961 3652 4342 PMC8666288__F2 Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis 22926 468 2475 85451 8678 81631 PMC8742263__F2 Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation 1499 50964 4090 4086 860 PMC8745381__F3 Melatonin in Obesity: A Review 7099 6774 100034700 406 4783 51129 2056 847 114548 4353 23411 PMC8773335__F5 Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach 914 9313 4313 4318 717 3553 27040 90550 1003 PMC8836222__F10 Comparative Transcriptome Analysis Reveals Mechanisms of Folate Accumulation in Maize Grains 1725 8836 4524 2356 4397 100271694 PMC8841219__F2 The renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19) 1636 5547 59272 PMC8849228__F8 Transcriptome Profiling During Muscadine Berry Development Reveals the Dynamic of Polyphenols Metabolism 1431 1312 790 28958 6950 727 729 178 PMC8891816__F2 miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review 983 1017 6774 3569 1021 1019 2475 5728 PMC8894711__F1 Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection 114609 4615 5879 841 8772 51135 3654 7189 3663 5132 3661 PMC8911152__F2 New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females 6774 7068 7200 7201 7253 581 2492 331 PMC8949908__F5 Betaine Supplementation Causes an Increase in Fatty Acid Oxidation and Carbohydrate Metabolism in Livers of Mice Fed a High-Fat Diet: A Proteomic Analysis 10330 79746 4703 462 51 10923 34 1933 10525 11112 26517 5373 10130 3030 6120 84181 131669 3959 1757 112817 9994 2597 808 10492 2950 79814 2944 54927 570 6104 55651 51602 5093 3150 336 PMC8953665__F4 Cholesterol metabolism: from lipidomics to immunology 3156 8435 6646 3949 3157 3158 2222 4047 1717 1718 9619 19 64241 64240 348 341 346 344 29116 PMC8958338__F10 Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications 4512 4513 4015 PMC8966686__F10 Integrative Transcriptomics and Proteomics Analysis Provide a Deep Insight Into Bovine Viral Diarrhea Virus-Host Interactions During BVDV Infection 1717 1718 2475 7189 8772 843 6885 836 840 839 2194 6319 5606 114548 3569 3725 57506 3661 7187 387923 3665 3458 338376 56832 PMC8971810__F4 C1q/Tumor Necrosis Factor-Related Protein 9: Basics and Therapeutic Potentials 929 7099 4615 7189 3383 3458 6774 2626 1000 PMC8997154__F2 Impact of Cannabinoid Compounds on Skin Cancer 57761 10533 4015 581 596 9290 PMC8999182__F4 Physiological Electric Field: A Potential Construction Regulator of Human Brain Organoids 1499 1956 7074 5879 6010 998 PMC8999811__F4 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs 4015 100187761 55775 1362 51411 PMC9001080__F3 Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals 9978 9817 8452 2729 PMC9023792__F1 Emerging Role of Hedgehog Signaling in Viral Infections 5727 6608 51684 2736 2737 596 4609 132884 156 PMC9036358__F1 Cyclic GMP and PKG Signaling in Heart Failure 594857 6262 5225 5997 5999 7225 PMC9055624__F2 Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease 1950 6714 3717 28964 1843 59272 5330 PMC9091820__F2 Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons 84740 7187 29110 57506 3394 596 3661 115004 7098 3665 7099 51284 4615 51311 3654 54106 3454 3455 7297 100885775 6773 6772 10379 4939 4938 4940 8519 8651 4599 4600 100506860 PMC9101148__F2 Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation 3717 6774 5443 181 5770 5771 PMC9125221__F6 Identification of Candidate Genes Associated With Tolerance to Apple Replant Disease by Genome-Wide Transcriptome Analysis 23179 57139 5863 3952 PMC9133562__F2 Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials 238 92 93 659 2885 7048 860 PMC9145045__F3 Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison 7297 10379 1642 3460 9636 3717 PMC9148284__F1 Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease Pathophysiology 83939 581 27429 9817 PMC9166240__F6 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy 51284 961 3717 387 6774 4321 2549 9846 7808 120892 7535 2475 1796 3479 4089 860 7378 PMC9175535__F4 Reposition of the fungicide ciclopirox for cancer treatment 7249 7248 6009 2475 64223 664 1977 PMC9202997__F3 Impact of Air Pollution on the Course of Cystic Fibrosis: A Review 435 581 572 594857 1080 472 3162 283571 3717 PMC9205222__F2 Molecular Approaches Reduce Saturates and Eliminate trans Fats in Food Oils 355 95 4018 PMC9231384__F5 tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research 7976 1499 595 324 PMC9231384__F6 tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research 4792 10146 4076 PMC9266358__F8 Transcriptomic and Metabolomic Analysis of Quality Changes during Sweet Cherry Fruit Development and Mining of Related Genes 2821 3795 6652 1312 790 350 47 5132 4149 PMC9266881__F2 Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression 6786 84876 759 2475 4087 4088 3579 7225 1956 6774 7220 847 7224 7223 761 PMC9292677__F2 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis 8877 3082 4005 7186 7204 11331 PMC9292677__F1 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis 8877 56848 4026 PMC9292677__F4 Uncovering the ‘sphinx’ of sphingosine 1‐phosphate signalling: from cellular events to organ morphogenesis 9294 4041 2932 1901 1499 124976 8877 4772 1903 4513 PMC9304552__F3 Metabolic Regulation of Cardiac Regeneration 1499 2064 2066 2475 5308 5106 10724 5465 2180 10135 27349 5166 5165 PMC9362342__F1 Cellular senescence and the SASP 648 2309 4193 2475 2114 1019 545 472 2626 2919 PMC9370344__F7 Waterlogging Stress Induces Antioxidant Defense Responses, Aerenchyma Formation and Alters Metabolisms of Banana Plants 3099 5232 5236 2023 2271 6390 47 84680 1879 5132 PMC9374747__F6 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states 7018 4656 9314 5465 2118 5989 3223 5090 5316 5970 2736 84662 7704 57594 1958 6672 6239 PMC9380335__F6 Impact of fetal exposure to mycotoxins on longissimus muscle fiber hypertrophy and miRNA profile 613 930 6850 2885 5879 5163 951 7249 572 4193 5934 4199 PMC9386448__F2 Phytochemical and pharmacological profile of taraxasterol 4615 7099 4513 2475 581 114548 3553 3569 79792 PMC9408924__F5 Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning 79875 4838 25805 387 6500 1874 PMC9414081__F11 Research progress on extraction technology and biomedical function of natural sugar substitutes 207 2932 2194 1374 PMC9419932__F4 Estrogen Signaling Dictates Musculoskeletal Stem Cell Behavior: Sex Differences in Tissue Repair 2078 1956 5728 5163 3479 PMC9448512__F1 Canonical and non-canonical AhR signaling pathways 8140 196 1543 1545 405 1316 PMC9454615__F2 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication 9817 8989 27035 PMC9454615__F5 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication 7189 7187 3665 4615 7098 7113 3661 8989 PMC9495382__F2 p53: From Fundamental Biology to Clinical Applications in Cancer 1021 1019 545 472 PMC9508608__F3 Methionine restriction - Association with redox homeostasis and implications on aging and diseases 4353 847 875 5465 468 26291 1728 2475 23411 PMC9534556__F2 Potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry 847 43 1103 581 PMC9575659__F9 Comparative physiological, transcriptomic, and WGCNA analyses reveal the key genes and regulatory pathways associated with drought tolerance in Tartary buckwheat 3298 3299 340451 PMC9598694__F9 Thiamine Supplementation Alleviates Lipopolysaccharide-Triggered Adaptive Inflammatory Response and Modulates Energy State via Suppression of NFKB/p38 MAPK/AMPK Signaling in Rumen Epithelial Cells of Goats 3586 7099 581 23411 PMC1297571__F6 Simplified diagram of the proposed signalling events leading to Cyp7b gene transcription in synovial fibroblasts 7124 8717 8772 7186 PMC150458__F3 Known Wnt signaling pathways 1499 324 387 759 PMC155638__F1 MAP kinase signalling pathways 998 6010 1386 2002 2114 2113 4208 PMC1781473__F3 Exploitation of Eukaryotic Ubiquitin Signaling Pathways by Effectors Translocated by Bacterial Type III and Type IV Secretion Systems 23118 257397 4738 10454 PMC1829419__F4 Hypothetical regulatory network influencing honeybee pollen foraging behavior modulated by insulin-like signaling and its effects on ovarian development 5303 5300 5728 5163 PMC1951533__F14 Proline-Rich Tyrosine Kinase 2 Mediates Gonadotropin-Releasing Hormone Signaling 6714 2885 1958 3972 PMC2080907__F8 Myc and Ca2+signaling events downstream of the pre-BCR/BCR 613 640 638 4067 2534 6850 7006 100124696 695 4609 5336 3492 PMC2148066__F6 GenMAPP pathway showing changes in expression of the transcription factor PPARA and fatty-acid degrading enzymes upon fasting 4023 5465 2820 1384 1374 1376 36 35 34 33 30 37 55825 3030 3032 1962 1892 PMC2196031__F8 Schematic presentation of the proposed sites of inhibition of the ceramide pathway by CrmA and Bcl-2 355 8772 253868 PMC2225459__F2 Schema illustrating the effects of (a) metformin- or AICAR-induced AMPK activation, (b)adiponectin, and (c) TZDs or PPAR alpha ligands on the rat granulosa cell steroidogenesis 3479 3480 51094 79602 5465 6770 PMC2245955__F5 Gene expression changes observed in Sema3A signaling pathway 10371 7869 9037 10512 54437 223117 57556 9723 10501 6405 10500 3897 64218 80031 5361 10509 8482 5362 54910 55558 10507 91584 8828 10505 81832 57715 81831 58 59 70 60 64780 27289 72 9645 6093 5058 51807 57553 10755 29984 3984 10552 10095 387 2242 8976 10381 5879 2534 1808 4638 10109 5880 2932 1809 10094 5881 1020 10570 1400 51174 10093 998 7283 27175 10092 81873 PMC2390572__F8 Major pathways affected by TFIIS knockdown in MCF7 6155 60386 6171 6144 11224 6228 6141 4609 4254 9349 1029 6046 7157 2261 2959 3654 8548 6597 367 3426 6601 3092 5268 10877 8828 4190 55558 PMC2464594__F4 Oct-4 Targets in the Wnt Signalling Pathway 51701 5468 5624 324 2932 4041 4040 9350 6477 6500 8454 9978 PMC2483283__F2 Coexpression of genes within three core metabolic pathways 178 586 100196919 367 3712 93650 54 52 PMC2483283__F4 Coexpression of the genes for fatty acid biosynthesis 52 93650 54 404713 PMC2533023__F5 Response of A549 cells exposed to crocidolite 3589 3569 10468 26585 8614 133 9518 7424 5744 7425 5328 8795 2335 5329 4916 2669 6809 2920 2921 3656 5608 8682 8877 10221 6804 3304 10018 8739 4616 5997 4929 196 7067 51330 3981 23645 1130 7128 1649 9314 51474 25976 4609 467 26524 415116 1316 7022 860 10370 604 1647 330 694 3621 2297 23327 1848 390 9021 5743 8835 3681 5914 6597 5728 6596 1869 7124 3972 PMC2570214__F8 Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2−/− Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM 1950 7248 7249 6009 PMC2584165__F2 Highly simplified diagram of signaling pathways involving Beta-catenin that may be relevant for RPE cell morphogenesis and susceptibility to age-related oxidative stress 4041 4040 1499 324 1000 7306 4286 PMC2586935__F4 TGFB pathway as affected by IGF2 administration based on Pathway-Express 4090 4086 4089 3458 4091 4092 7124 9978 64750 57154 8454 7057 6500 4087 4088 1874 7046 387 6093 10468 5308 4838 PMC2587278__F1 Oxidative and alkylation DNA damage is effectively repaired by the DNA BER pathway 3131 4968 79661 4350 3091 1958 7038 PMC2605957__F7 Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway 948 4280 3082 5447 PMC2617762__F6 Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia 4094 9817 192111 PMC2629585__F7 Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response 1401 716 715 717 718 PMC2635620__F2 Inhibition of each signaling molecules by natural products in insulin signaling 5163 2475 6714 5728 PMC2650409__F6 c-Src Regulates Akt Signaling in Response to Ghrelin via Beta-Arrestin Signaling-Independent and -Dependent Mechanisms 5163 64223 253260 2475 5978 PMC2652397__F1 Dual Roles of Nrf2 in Cancer 9817 9978 8452 4094 PMC2680597__F1 Methylobacterium Genome Sequences: A Reference Blueprint to Investigate Microbial Metabolism of C1 Compounds from Natural and Industrial Sources 3250 2645 718 717 4434 727 5095 5096 PMC2696288__F7 Protein Acetylation Microarray Reveals NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis 23411 5091 5105 PMC2700035__F6 Load-driven signaling pathways predicted with ankle loading at 1 h after the last loading 53366 1101 961 1499 5624 2713 324 5925 4089 4092 9350 220134 387 10468 PMC2714846__F6 Estradiol-17B, prostaglandin E2 (PGE2) and the prostaglandin E2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium 5732 5743 873 PMC2723760__F4 HERPUD1 Ingenuity Pathway Analysis illustrates interactions between indicated proteins 10797 90411 4783 440 10538 7494 10488 6746 7009 1628 9709 2081 38 4191 9341 PMC2744676__F2 Diagram depicting proliferative and survival signaling pathways in cells 1950 5266 2475 581 572 1021 1019 331 1956 PMC2754915__F3 Signalling events which determine glucose utilization within the cell 5728 3667 57103 9997 PMC2756960__F8 Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs 3479 3480 5728 3667 11315 10628 2475 PMC2784807__F5 Ingenuity Pathway Analysis® network depicting relationships among genes involved in immune and metabolic responses due to IMI with Streptococcus uberis 4057 5328 5329 929 948 6403 4023 57678 6647 6319 23175 602 2353 PMC2794543__F8 Activation of Wnt/Beta-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells 7480 2885 208 207 1499 PMC2805706__F3 Brain foods: the effects of nutrients on brain function 3479 627 2475 PMC2810629__F1 Tale of Transforming Growth FactorB (TGFB) Signaling: A Soigné Enigma 1601 4087 4088 10454 7189 4089 57154 2932 387 PMC2814453__F1 Coupling between Akt-mediated cellular energy metabolism, cell survival and proliferation 5163 5728 7249 7248 6009 PMC2818318__F4 Regulation of Cell Cycle and RNA Transcription Genes Identified by Microarray Analysis of PC-3 Human Prostate Cancer Cells Treated with Luteolin 51050 1027 5111 995 891 9133 896 9134 8900 2932 85417 894 898 890 902 5347 1019 1021 1017 990 25 7465 5925 6502 5933 8317 7027 PMC2820477__F2 Scheme of known Wnt pathways 57216 4920 6259 998 387 388 324 4040 4041 PMC2822520__F7 A working model for endosomal transport involving CLC-5 and KIF3B interaction in polarized cells 9371 11127 11060 PMC2827926__F3 The refined scheme of the glyoxylate regeneration cycle, now termed ethylmalonyl-CoA pathway (right), and its connection to the serine cycle (left) 2645 3250 4434 PMC2844426__F4 Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) 2885 4763 5894 84867 2872 PMC2886346__F10 The pathway signaling to ERESs 1950 1956 4763 4214 PMC2898136__F1 Eicosanoids and cancer 4513 4049 5228 5226 4050 PMC2898136__F6 Eicosanoids and cancer 2247 1956 998 6347 4513 4050 7852 PMC2905205__F1 Signalling routes of copper and hydrogen peroxide 5163 10006 10152 4881 2597 PMC2921957__F4 Summary of factor H recognition functions and interactions 2271 7054 1401 PMC2930269__F2 CSCs drug resistance methodology 5243 9429 4255 961 PMC2953497__F10 Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells 9883 23291 4792 871 6232 6231 4791 6671 2307 6208 672 7314 5118 1958 4851 488 3157 84961 3714 57154 51676 4090 4086 5068 5655 PMC2954312__F2 Crosstalk between the three distinct oscillators that function in the mouse PSM.(a) Schematic diagram of a signalling and a responding cell in the mouse PSM, detailing cyclic genes of the Notch, Fgf and Wnt pathways 89780 8313 324 1499 51176 85407 84667 441478 7018 2260 3955 1846 10253 7939 PMC2954851__F2 Protein serine/threonine phosphatases in the DNA damage response pathway 5810 4361 10111 672 545 84126 472 4193 3014 PMC2966944__F8 Cartoon summary of expression and anatomical data, and a model for phases of A/P axis re-organization 6422 6423 7472 7471 1499 5550 PMC2992289__F5 KLA increases mRNA expression of genes involved in sphingolipid biosynthesis 56848 56624 79603 29956 10715 204219 253782 64781 6610 PMC2993855__F2 Pathways correcting DNA polymerase errors 4436 2956 4437 4292 5395 27030 PMC2996105__F7 Interaction of p75NTR and TrkB signaling 2549 2885 5728 5163 572 581 PMC3027158__F7 Biological network of genes linked to the canonical pathway "molecular mechanisms of cancer" that were hypomethylated (fold change >1.5) in zebrafish hepatocellular carcinoma compared to healthy liver 4763 2922 759 572 472 717 3725 581 4149 4311 4193 1356 10763 5933 637 324 63923 51684 PMC3042723__F2 Signaling pathways regulating dendritic spine actin remodeling with the induction of LTP by theta burst stimulation (TBS).Schematic of signaling pathways linking three classes of synaptic to regulation of the actin cytoskeleton 387 998 6714 PMC3055312__F1 Signaling pathways regulating GSK3 and functions of GSK3 related to mood regulation 627 4040 4041 5163 27185 1499 7018 PMC3075371__F1 Local control of Beta-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient 9118 8213 3382 759 PMC3076924__F2 Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders 22926 2475 836 627 PMC3091762__F9 IPA representation of the complement system pathway enriched in cluster 6, 3 hours post-infestation with P 721 717 720 1378 729 727 730 966 1380 PMC3092604__F2 Lipid remodeling pathways in mammals, yeast and T 27315 93210 683 5187 80157 PMC3096649__F7 IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis 3479 3667 126669 857 3480 2885 PMC3110938__F2 Genome-wide dissection of microRNA functions and co-targeting networks using gene-set signatures 3479 3082 3630 3643 4215 5770 5879 6010 998 57580 2475 9586 PMC3134268__F1 Schematic representation of the influence of photoperiod on deiodinase enzyme gene expression in the hypothalamus 7252 1735 1734 7253 PMC3140170__F10 Nicotine signal transduction pathways 1003 5894 572 PMC3141076__F6 Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression 84649 80168 2819 2597 2194 5164 5105 5313 728609 1638 PMC3143721__F5 Putative crosstalk between D1and TrkB receptors in striatal direct pathway neurons controlling PPD mRNA expression 273 627 5894 PMC3146511__F6 Expression and Functional Roles of Angiopoietin-2 in Skeletal Muscles 1058 4775 57405 83540 4602 11004 3832 10403 8318 3569 6241 55388 11065 4001 324 9787 55132 PMC3149005__F6 Summary of the UPR pathway in rotavirus infected cells 22926 468 5979 PMC3164695__F7 The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO 23411 1647 3484 PMC3188430__F7 miR-486 is an important regulator of PTEN/AKT signaling in normal and dystrophic muscle 5728 286 5159 5295 PMC3208056__F4 Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/Beta-catenin/cyclin D1 signaling pathway in rats 1499 324 4513 596 PMC3218922__F6 Pathway generated by ingenuity pathway analysis with proteins identified as specific target antigens 2923 7414 6175 302 7430 4000 5962 4478 4869 3315 2023 7417 3184 7124 308 2171 3565 10507 2885 3615 2271 7284 5478 7358 10935 PMC3229036__F2 Subversion of the actin cytoskeleton during viral infection 999 6714 619537 2160 5879 998 387 6093 9475 3984 3985 PMC3251883__F4 Proposed mechanism for VEGFA165 induced tumour growth 4283 7076 3574 3458 7422 3575 6655 6654 4090 4088 4092 4089 7018 58487 3665 861 PMC3283059__F2 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway displaying transcripts in mitogen-activated protein kinase (MAPK) signaling pathway 1610 1956 5894 6722 4342 4763 2316 90459 3725 7124 355 4149 4208 23118 51295 PMC3283059__F4 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway display transcripts in cell cycle pathway 5885 1874 4087 4088 4089 6502 324 991 699 5111 990 4661 1869 10926 PMC3294166__F8 KEGG pathway mapping overlay for acidic pHe upregulated genes pertinent to OXPHOS 4519 4541 4537 4536 6392 6476 4514 100653365 PMC3303610__F3 Ang-(1-7) signaling in cardiomyocytes 4842 2932 4846 PMC3309939__F8 Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling 5266 200576 23678 PMC3314677__F9 Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide 2932 595 1017 7186 841 836 581 PMC3317991__F6 RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer 2475 999 596 1019 PMC3319358__F1 Gut triglyceride production 84803 137964 4099 8694 84649 641 PMC3319358__F2 Gut triglyceride production 8694 4247 84649 39 7038 51128 100170220 6845 641 PMC3319919__F2 Components of the TLR pathway and genes commonly induced during the innate immune response of zebrafish to bacterial infection 4615 51135 11213 54472 3654 7189 29110 257397 10454 23118 4118 10682 4602 4609 4318 4322 3553 3586 729 629 718 329 842 2153 2243 2244 7779 653361 PMC3328452__F8 Identification of Protein Networks Involved in the Disease Course of Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis 203068 822 3778 10096 5223 8775 63908 4744 1743 2023 60 351 7846 2923 183 219793 PMC3331761__F4a Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes 3667 847 3265 2885 331 5740 1431 PMC3334999__F5 Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation 27123 7042 8321 8323 999 7046 7048 207 208 324 2932 51701 1499 6664 6657 6666 55198 960 6925 3725 PMC3337162__F2 Polarization of migrating cortical neurons by Rap1 and N-cadherin 5900 7410 5898 5879 5899 998 8826 10928 PMC3338606__F6 Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NFKB Signalling 7099 389692 4615 PMC3342334__F9 Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway 5163 7248 7249 6009 1977 23237 PMC3347988__F4 Schematic overview of the pathway controlling translational changes in adipogenesis 4609 27343 11201 1975 PMC3349304__F6 Identification of transcripts and proteins associated with hemocytes 7448 4615 7189 718 967 5966 9618 PMC3352961__F3 Brain, blood, and iron: Perspectives on the roles of erythrocytes and iron in neurodegeneration 23230 5879 5058 7504 PMC3377280__F7 Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition 5347 5888 7465 983 PMC3377643__F2 TGFB and Iron Differently Alter HBV Replication in Human Hepatocytes through TGFB/BMP Signaling and Cellular MicroRNA Expression 4087 2885 6497 4092 7189 7421 7030 3224 860 864 5308 145258 4838 3196 PMC3381108__F2 Unfolded protein response (UPR) 836 581 7186 22926 83939 7494 468 PMC3384717__F9 Androgens up-regulating PCa cell proliferation via p66Shc-ROS signal pathway 367 2876 2064 PMC3386226__F8 Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner 545 84126 286204 11073 PMC3386270__F8 IL-4 Engagement of the Type I IL-4 Receptor Complex Enhances Mouse Eosinophil Migration to Eotaxin-1 In Vitro 6714 2885 1232 6010 6778 998 5879 PMC3414427__F3 Schematic model showing the existence of distinct secretory pathways in pheochromocytoma 4852 6616 7054 5409 8618 1621 PMC3432059__F6 Establishment of Mouse Teratocarcinomas Stem Cells Line and Screening Genes Responsible for Malignancy 51701 4088 9350 6500 6477 8454 324 2040 387 9475 PMC3444914__F1 The DNA base excision repair (BER) pathway 5426 5111 7515 3980 PMC3465249__F3 Changes in hepatic gene expression in the KEGG PPAR signalling pathway in SNEB compared to MNEB cows 5360 4023 4312 7350 3611 7316 PMC3466406__F7 Biological insights obtained by combining logical modeling and experimental data 1950 3082 7124 2885 2932 1021 1019 PMC3469769__F2 Multiple roles of COUP-TFII in cancer initiation and progression 2494 3791 4878 5465 337 5915 3990 7026 345 9971 8829 6462 217 5948 5105 6548 PMC3480380__F8 Regulation of Epidermal Growth Factor Receptor Signaling and Erlotinib Sensitivity in Head and Neck Cancer Cells by miR-7 7039 1950 1956 2885 3611 5728 5163 7124 84969 11140 7248 572 4193 7249 6009 79923 595 2475 6722 PMC3485747__F1 Glutamine:fructose-6-phosphate amidotransferase 1 (GFPT1)–mediated MTOR signaling pathway affected by glucose and fructose in porcine trophectoderm cells 207 2673 7249 2475 6194 1978 PMC3507431__F2 Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy 2475 5728 23411 6714 5163 PMC3513366__F1 Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells 387569 3240 1499 324 673 4280 7038 5266 6774 9201 960 4440 PMC3517080__F5 Putative Altered Signaling Events occurring upon treatment of GSI 4627 10381 2670 7416 5036 5111 PMC3517581__F7 Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal SH-SY5Y Cells 81563 3309 284217 54552 23531 659 4780 2670 3569 7124 596 333 1993 5178 51616 8434 27115 PMC3525723__F4 Insulin signaling transduction 5163 5950 2475 572 581 PMC3533463__F1 Biosynthesis pathways of phospholipid components in archaea 4598 2695 91734 PMC3533650__F10 Regulation of the FOXO3a survival, and glycolysis pathways under hypoxia in Spalax 2475 5728 10370 4609 3099 5163 3939 PMC3538603__F8 Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation 7054 1630 387 998 2534 3265 5998 6092 6091 2242 8829 27289 29984 8551 5724 2834 2798 117192 4018 7253 6344 1241 5021 2690 3953 3952 6865 5617 5618 PMC3542528__F4 Protein network analysis of hits reveals multiple connections between signaling molecules and Golgi proteins 2011 57787 1612 23617 9833 8999 51701 5613 6198 5581 6733 6732 10746 2645 4485 29959 340371 7006 100124696 51231 8317 6902 2065 2322 1455 8767 885 2263 3627 558 2041 2596 3055 7046 8527 4882 10076 5786 8525 5792 858 8417 122481 10112 6616 3937 660 11345 2804 7533 5007 2633 9276 5515 3098 8789 2697 9212 699 56940 5609 1844 79858 4751 PMC3573348__F2 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECb vs 58985 6746 9934 6233 55596 51076 10736 11137 8446 51528 6938 6729 3172 64783 29100 51096 55972 23256 51015 83699 26998 9321 2255 1559 846 10631 9982 10664 9880 3308 2959 2494 6872 10923 5066 10809 10865 6829 1161 1643 905 4778 23476 PMC3573348__F3 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECe vs 10657 3157 5781 7012 5584 5529 7071 4953 817 29966 22794 2494 4696 1112 8826 6130 3700 6160 1874 3172 4089 10617 27252 6576 9493 5321 9584 54861 11338 PMC3573348__F5 Ingenuity Pathway Analysis (IPA) of genes differentially expressed in ECb vs 6233 6421 7316 4656 6745 5469 6217 665 7155 6189 1460 4311 7363 5912 29761 5646 7375 6125 10808 6194 8661 3320 1977 10728 26986 7335 3308 2959 7001 6872 9618 PMC3575576__F6 Proposed signaling pathway 7043 7291 999 PMC3590501__F6 Proposed mechanism for the protective effects of carvacrol against hepatic steatosis in mice 3156 2224 1717 2475 3663 51141 4615 22937 355 3661 948 929 PMC3595017__F1 Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses 57506 8717 3661 3665 10010 8772 PMC3606520__F6 Summary of the putative biosynthetic pathway of non-arthro and arthro-series neutral GSLs in the cyst of the brine shrimp 100187761 9350 29851 PMC3609811__F1 Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress 1281 960 7450 255743 1101 9672 8515 948 3676 3694 961 PMC3610926__F2 Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII 90550 5350 857 858 859 613 952 PMC3616967__F4 Proposed model for iAs-induced birth defects via the GR pathway 2908 4792 595 5829 4087 6722 7428 4846 6774 5970 1499 4843 596 836 5925 355 PMC3625556__F7 The possible molecular mechanisms of pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis in rats 1499 595 581 PMC3653932__F7 TLR4 Activates the Beta-catenin Pathway to Cause Intestinal Neoplasia 7099 8549 4615 8312 324 595 PMC3665348__F8 Summary of differential metabolism of procainamide in humans and mice 2326 2328 1565 1543 PMC3672007__F2 Ingenuity pathways analysis canonical pathway IGF1 signaling This figure shows the IGF1 signaling pathway, with significantly upregulated genes in red, downregulated genes in green, and genes that did not meet our criteria for significance in gray 3486 3479 2887 3480 6774 572 79629 3725 PMC3682751__F3 Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity 9118 1356 6955 759 PMC3684430__F1 Apoptotic pathways regulated by the UPR 581 7186 83939 468 596 30001 PMC3691323__F6 Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain 324 983 10270 822 3619 7150 PMC3693156__F1 Cholesterol synthesis pathway 387 998 5879 PMC3693914__F2 DA biosynthesis and degradation 7054 1312 367 PMC3705552__F2 TIR8/SIGIRR, a negative regulatory receptor of ILR and TLR signaling 59307 4615 2475 PMC3708286__F2 Signaling pathways that relate disturbed polycystin-mediated Ca2+signaling to cell proliferation 6714 7249 7248 PMC3713848__F9 Proposed model for the integration of primary afferent, mast cell and sympathetic systems in supporting CRPS-related nociception 4803 3553 10267 3569 PMC3728089__F5 Cholinergic anti-inflammatory pathway 7099 2066 3717 6774 PMC3736525__F4 Lycopene inhibits theWnt/Beta-catenin pathway 3476 3480 324 7077 1499 6667 PMC3744831__F2 DDR-adapted model in meiotic silencing 23626 9656 3014 545 472 11073 PMC3760899__F3 Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation 4221 85453 57106 10289 1026 1647 374 599 8877 581 23397 4494 PMC3775856__F10 Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation 7035 5340 831 PMC3814314__F5 Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish 4838 4035 4151 6497 6714 324 1499 51701 11011 5308 1482 145258 6422 22943 PMC3819741__F2 Identification of the genes in the MAPK signaling pathway that harbor or are in the close proximity of SNPs associated with feed efficiency 1610 4803 4351 6722 3725 6697 1386 759 355 1616 4149 929 51295 PMC3821664__F4 Biosynthetic pathway of major phospholipids in vascular endothelial tissue and mononuclear leukocytes 95 7038 907 5091 PMC3823158__F1 Canonical NFKB signalling pathway 8717 7186 10892 8915 PMC3843359__F2 MAPK signaling pathway is upregulated in OSI-906 resistant CRC lines 3630 2885 5163 5164 2475 7249 7248 6009 2002 1977 3643 PMC3852044__F3 MAPK signalling pathway 627 8314 2002 2885 5901 6722 4342 2316 7124 7186 355 1616 4149 4208 929 23118 7189 51701 PMC3852044__F4 Wnt signalling pathway 51701 324 6500 8454 6477 9475 387 PMC3856408__F1 Endogenous small RNA pathways involved in host defense and viral pathogenesis in plants and animals 192670 26523 27161 29102 54487 PMC3857153__F8 Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells 255738 330 7186 7124 7128 8835 673 10370 PMC3872778__F2 Similarities between NAA synthesis and citrate synthesis 1431 5132 4118 PMC3875633__F4 Invasion gene signaling networks (GSNs) of (A) chronic CNT-exposed and (B) chronic asbestos-exposed MeT5A cells 3485 1233 25803 682 1956 64386 5970 10631 6790 PMC3890654__F1 Toll-like receptor-4 signaling pathway 7099 929 59307 4118 8651 4615 54472 3656 7189 23118 257397 3725 2353 PMC3901678__F6 Mining Gene Expression Data for Pollutants (Dioxin, Toluene, Formaldehyde) and Low Dose of Gamma-Irradiation 367 7454 6855 1638 107966124 PMC3919163__F2 LPS receptor signaling pathways 7099 4118 4615 3654 7189 7187 3663 10454 23118 257397 29110 3661 PMC3920946__F1 Serine, one-carbon cycle, glycine synthesis (SOG) pathway 26227 1719 5723 4524 4397 6470 4522 6472 10797 2618 441024 471 25902 81034 2638 2731 1738 275 23530 PMC3924831__F2 Apoptosis signaling under ER stress conditions 581 7186 83939 468 PMC3928987__F2 Cyclooxygenase pathway of AA 4512 5228 5226 PMC3936888__F7 Scheme for illustrating the effect of Naproxen on the regulation of cell cycle and apoptosis mediated through the inhibition of the PI3-K signaling pathway 2475 1019 596 581 PMC3937030__F1 MTOR pathway signaling pathway 5091 2475 1938 2000 1975 PMC3942330__F4 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms 1950 1956 5879 207 6714 27035 836 842 PMC3951427__F12 New miRNA Profiles Accurately Distinguish Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas from the Normal Kidney 574449 22808 4609 64065 8726 693200 8567 100187761 PMC3960487__F2 Signaling pathways involved in YPP regulation 7248 7249 6009 253260 5728 PMC3964016__F1 Cl− channels and proposed functions in vascular smooth muscle cells 1080 367 8411 27035 5879 1179 PMC3966871__F3 High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells 4001 444 51280 29127 54788 57655 83752 7153 23089 1894 54443 160418 2342 3433 3915 10458 27249 10934 9212 3437 4059 6319 3268 7841 9636 27338 51142 55015 23085 9415 4924 8974 84164 2720 5660 60343 1019 558 23225 4897 53981 7871 54539 11230 7045 57513 203547 55833 351 55858 1191 1386 1999 115817 6782 9919 1387 10618 6731 8664 8662 9203 83855 5355 6729 1017 10525 5433 88745 1917 25792 3725 5970 23760 891 55696 1272 4069 6790 10112 PMC3979163__F1 The canonical Wnt signaling pathway 2932 1499 6010 324 PMC3981821__F4 Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus 47 55744 3156 1717 38 1718 3157 10682 4047 4598 6713 3988 8435 PMC3981821__F6 Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus 5471 10797 221823 5634 5236 55276 22934 2645 5226 2539 6888 57818 92579 7086 2821 5211 2203 226 229 230 7167 2597 6470 6472 5230 29968 5723 5223 5224 10993 2023 5313 3939 PMC3983859__F6 Schematic representation of the RvD1 contribution to microglia alternative activation 2358 3566 383 6778 PMC3984536__F3 HCV life cycle and points of intervention 348 1969 1950 1956 3949 338 975 7038 9076 100506658 29881 406906 57762 8694 PMC4023931__F3 Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma 64081 51741 26524 7157 4609 5925 5728 4173 1029 613 598 2074 9967 5673 284565 6708 8683 3150 114625 9448 2353 1288 7444 355 2857 58504 26278 6320 2911 6678 PMC4031100__F3 Nutritional metabolomics: Progress in addressing complexity in diet and health 4118 10165 4975 6539 PMC4038253__F1 Simplified scheme of the N-glycosylation pathway 85365 91869 79087 56052 79868 1798 10195 29929 84920 4247 4248 PMC4041829__F1 Overview of cellular Na+ transport mechanisms and important components of the salt stress response network in plant root cells 4602 2077 6655 PMC4048950__F10 Redox control of p53 in the transcriptional regulation of TGFB1 target genes through SMAD cooperativity 1956 472 545 4088 4089 4087 7392 PMC4051765__F1 Responses of the Insulin Signaling Pathways in the Brown Adipose Tissue of Rats following Cold Exposure 867 1398 6844 2549 5728 9021 2885 7249 572 2475 2887 1977 PMC4057758__F6 Graphical representation of two of the top score networks identified by Ingenuity Pathway Analysis (IPA) 472 545 4193 4089 4088 4149 3084 25942 6839 1719 5111 672 PMC4059866__F4 Gene network generated by Ingenuity Pathway Analysis of 5 genes identified to be predicted targets of miRNAs associated with in vitro cisplatin resistance (fold change > 2, P < 0.05) in the current study 7161 2965 7341 8243 26057 PMC4061877__F4 Hypothetical outcomes for demyelinated axon.Denuded axon impermissive for myelination 84894 7045 4340 4099 PMC4074033__F6 Kaposi Sarcoma Herpes Virus Latency Associated Nuclear Antigen Protein Release the G2/M Cell Cycle Blocks by Modulating ATM/ATR Mediated Checkpoint Pathway 545 472 995 PMC4090493__F6 Proposed mechanism by which -shogaol inhibits melanin biosynthesis 4157 4286 7018 PMC4123742__F3 Current model for replication-independent ICL repair 7508 2067 7507 51455 353497 51426 PMC4148147__F7 Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells 5132 51284 57506 4615 7187 3654 3665 2155 7124 PMC4149909__F2 Gaps in conventional treatment of heart failure include deranged Beta-AR signaling, distorted Ca2+ cycling with depletion of SR Ca2+ levels, diastolic dysfunction, and cell death 367 790 156 5350 6262 572 PMC4190552__F1 Roles of leukotrienes and acetylation in the expression of pro-inflammatory mediators through the NFKB pathway 4049 4050 57105 10800 5971 PMC4227170__F2 CD147 plays an important role in a variety of cells and tissues regardless of health or disease 7124 9429 1956 619501 960 2638 PMC4234693__F4 Influence of non-canonical Wnt signals on the MAPK pathway 367 1499 2932 324 4312 4314 4318 4322 6662 860 PMC4246201__F10 Relationship between GPxs and the NFKB pathway in the antiproliferation action of butyrate 2878 2879 7412 PMC4248024__F1 The NAD pathway model 65220 53343 8505 93100 4553 203447 4860 4837 PMC4259860__F7 Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency 2937 25796 226 2023 2597 8667 1738 4522 7414 7431 4478 2934 353 1743 58533 10961 9871 PMC4270942__F7 Estrogen Regulates Energy Metabolic Pathway and Upstream AMPK Kinase and Phosphatase Enzyme Expression in Dorsal Vagal Complex Metabolo-Sensory Neurons during Glucostasis and Hypoglycemia 100188864 5211 3418 355 PMC4277436__F1 IL-33/ST2 pathway: therapeutic target and novel biomarker 4615 4118 90865 7189 PMC4287412__F9 Regulation of Wnt canonical and calcium-dependent pathway molecules in microstructured Ti surfaces 6422 7474 50964 89780 22943 27123 324 4920 PMC4297187__F2 Schematic summary of the results obtained from the microarray analysis 11197 22943 27122 6422 6424 8321 4041 4040 8324 81839 166336 85458 1856 64321 8313 23500 30851 7091 8061 1488 PMC4299486__F1 Cell signaling 92369 7531 55679 51773 7124 351 7040 27239 94103 2353 7157 84636 8812 79184 56254 80045 29909 390212 6750 PMC4316382__F1a BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells 51684 6608 91653 2619 PMC4316787__F3 Top-ranked enriched canonical pathway identified using IPA at 2 hpi – the IL-10 signaling pathway 3929 3716 7297 9021 6774 3162 6667 PMC4327822__F5 mGluR1/5 signaling pathways relevant to protein synthesis 5163 5164 7248 5894 2475 6009 29904 1977 1998 1938 PMC4337883__F2 Choline metabolism in malignant transformation 6667 5900 907 56994 PMC4353379__F2 Proteins implicated in neurodegenerative diseases are involved in multiple steps of the miRNA biogenesis pathway 29102 100187761 54487 2521 26523 PMC4353731__F1 Treatment of heterotopic ossification through remote ATP hydrolysis 655 26585 633 650 652 4321 860 7076 25928 5054 94 659 4086 1387 4487 90 1749 3398 1281 3400 7040 7852 PMC4365328__F1 HA precursors biosynthesis and main HAS2 regulation in SMCs 2695 7358 8473 3037 PMC4365493__F8 The signaling pathway through which MIF increases vascular permeability 4282 972 960 3579 7852 1003 2475 9474 PMC4373397__F2 Mucosal barrier integrity and inflammation 64806 90865 85480 7908 6347 3553 920 4295 PMC4375924__F5 Discordant and concordant gene expression in the PI3K-Akt-mTORC1 signaling cascade 5163 7249 7248 5728 6009 64798 2475 64223 3646 1977 1975 PMC4383231__F1 Intracellular fatty acid metabolism 948 4023 137964 84803 4018 4099 150763 PMC4384327__F3 APP protein-protein interaction networks 2358 27076 6387 23114 6693 334 5649 2319 3339 351 284217 100 43 6812 1742 134 2512 58191 929 9784 6354 9170 348 2934 8997 9146 1759 5027 6653 11276 6622 7804 1601 PMC4389563__F1 Time-resolved metabolic reprograming during pro-inflammatory macrophage polarization 23729 2147 4513 3569 7099 PMC4399414__F11 Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech 3929 51135 7189 7322 PMC4414306__F4 Growth hormone signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) 3717 3667 6774 6772 5163 6722 2002 1050 3481 2 PMC4414306__F5 IGFs/PI3K/Akt signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) 3481 3479 5728 5163 6844 7249 7248 572 5140 2475 1977 PMC4414306__F7 NRF2-mediated oxidative stress response 9817 4094 5479 316 7295 2690 2019 344901 6307 5569 29968 6916 6263 PMC4417485__F1 Fission Yeast-based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity 9815 28964 2203 PMC4417587__F1 Metabolic pathways associated with 5-HT 169355 3620 6999 121278 7166 1644 125061 11185 8564 4129 4128 51166 15 217 224 8942 438 23498 PMC4439562__F4 GPCR (or GPR) signaling in the regulation of Beta-cell proliferation 685 1956 2695 8660 2696 23411 894 1499 6934 3170 3651 1017 PMC4444189__F6 MicroRNAs Regulate Cellular ATP Levels by Targeting Mitochondrial Energy Metabolism Genes during C2C12 Myoblast Differentiation 4725 1339 4723 4713 4724 84701 PMC4453221__F1 Wnt/Beta-catenin signalling pathway 6422 50964 4041 4040 324 PMC4459083__F1 Scheme for producing fatty acid-derived biofuels in yeast 5053 100188785 355 5132 PMC4472151__F4 BMP signaling and its regulation 1386 1749 4488 3397 64750 324 999 7018 6497 7020 2113 7189 PMC4484229__F5 Serum C1 competes with Wnt for Fz receptor binding, resulting in Wnt canonical pathway activation 4040 4041 324 1499 PMC4485953__F2 New Model of Reverse Cholesterol Transport: EnTICEing Strategies to Stimulate Intestinal Cholesterol Excretion 1071 3949 255738 29881 39 64241 64240 PMC4490005__F3 Vav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28 2885 2534 5335 3932 1445 7409 3702 5163 5728 8915 5966 3550 2353 3725 PMC4496188__F10 The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1 1950 1956 6714 10397 5879 5058 PMC4496299__F4 Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation 4632 1356 7145 9211 5950 489 338557 7137 23239 653 1965 4130 55544 3667 348 10825 8289 35 1652 255738 7350 51129 4738 3745 8842 9863 33 5465 39 9810 6751 6121 PMC4497368__F1 The signaling pathway involved in EPO-induced neuroprotection 2056 3717 6774 6010 581 4318 2057 PMC4497387__F1 Radiation-induced acetylated and deacetylated proteins 2783 7531 3921 6206 6187 3842 6203 6136 4869 60 6235 PMC4505959__F10 The molecular events leading to the production of IL-10 in macrophages exposed to S 7097 7099 114609 4615 4791 1958 2353 50 83440 4705 PMC4511103__F4 Programmed Cell Death in Animal Development and Disease 1356 474168 7473 PMC4511561__F5 Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome 9126 4087 4088 4089 699 9184 1017 1021 1019 1022 4661 1869 1874 10926 4998 4999 23595 PMC4516713__F6 Brain signaling network reprogramming in response to mild mitochondrial uncoupling 3479 3480 7248 7249 6009 23237 627 5163 468 6446 PMC4523383__F1 Synthesis of estrogen, progesterone and testosterone from cholesterol 1583 3283 3292 PMC4531144__F1 Schematic demonstration of PHB-mediated survival or apoptosis responses in multiple cellular compartments of different cell types and molecular mechanism involved 5245 11331 4976 PMC4540190__F8 Schematic diagram outlining the novel molecular targets of CAFG leading to bone anabolic effects in osteogenic cells and fracture healing induced by BMP2/Wnt/Beta-catenin pathway 22943 650 50964 4086 1499 4089 100187907 860 PMC4568768__F1 FSH signaling 2492 100034703 5163 PMC4576413__F3 Redox control of protein degradation 8453 9978 7428 8452 8454 3553 9817 PMC4581211__F8 Proposed model of role of RNase L in crosstalk between autophagy and apoptosis 4938 6041 596 581 PMC4592361__F7 Involvement of LRP6 in the PTH-stimulated anabolic bone effect 4040 5741 1499 50964 PMC4599578__F6 Cancer-promoting GSNs in A) D-SWCNT, B) D-MWCNT and C) ASB neoplastic-like transformed SAECs 5468 2353 80781 4609 5168 1437 960 6623 3551 3624 6502 885 472 6886 4194 6688 59277 4313 467 57498 PMC4602270__F6 Label-free Quantitative Analysis of Changes in Broiler Liver Proteins under Heat Stress using SWATH-MS Technology 8940 4060 10516 1312 51478 10631 11005 6567 5336 197 1536 1511 3248 51072 7184 2671 19 1267 27248 635 4047 PMC4624764__F8 Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells 7046 387 4092 4087 4088 4089 50507 4090 4086 6667 6722 5308 57591 57496 93649 9314 4629 2627 PMC4629535__F4 Proposed p53 signaling pathway in PQ-treated rat lungs 5728 545 472 28996 1499 1869 672 4193 581 64065 355 57103 2765 9049 PMC4629535__F6 Canonical pathway and gene network analysis of the 26 identifiers that were expressed in the lungs of PQ-treated rats 5053 54880 359948 9263 54538 1521 112858 1371 1723 1604 55157 27244 8685 6667 200734 55602 2004 602 3172 79679 4846 7157 114112 53354 8445 28996 7316 54941 4214 84446 9131 6464 85451 79671 10314 11221 7534 2915 22848 84636 83873 23241 317702 653519 317701 83551 PMC4671616__F7 TGFB Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth 57154 387 4087 4088 29102 PMC4673238__F5 Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells 7006 100124696 2534 3932 2885 867 3702 27040 2922 3725 PMC4677035__F6 FcGR-mediated phagocytosis pathway in the KEGG database is the putative pathway which is related to TNFA and TGFB1 expression in microglial cells 27040 9846 4082 6850 7408 PMC4677255__F2 Detected regulatory influences on the canonical Wnt pathway 147111 27123 2487 4038 4040 4041 23327 23500 85407 144165 324 57154 84722 120892 8313 1499 348 9618 79960 23043 26502 7090 6941 83439 51176 28951 10085 PMC4699913__F4 Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling 5111 65123 472 545 56254 56897 2177 2475 1108 1616 8243 8648 4841 6697 9493 11200 30062 5371 8914 1432 8554 983 581 7508 PMC4700477__F10 Selected potential Rho GTPase functional networks identified in the RNAi screen 387 85440 5879 394 10395 26999 10006 4690 23191 8874 9475 1894 23348 9578 998 7204 6010 PMC4714567__F6 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs 1543 196 100188857 1017 1316 405 PMC4723075__F10 Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte 3554 7189 3654 8195 3727 3726 PMC4745841__F7 Functional interpretation of the IL-6 gene signature and its relationship to the three main downstream pathways of IL-6.Notes: The 17 genes are part of the Jak-STAT IL-6 downstream pathway 6774 367 10682 12 1052 1645 10381 629 79838 2634 1646 6278 3934 8519 10581 6279 10410 6280 PMC4746415__F2 Expression of genes involved in the fibroblast growth factor (FGF) signaling pathway during goat pre-implantation development 79923 993 6657 1045 2626 PMC4751587__F2 PI3K/AKT/mTOR signaling pathway and a proposed model for its regulation through the evaluated miRNAs 2475 2064 2065 3667 406912 5728 7248 64798 7249 6009 9776 1977 PMC4765310__F2a Importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes 4615 3654 51135 7189 3656 23118 257397 7187 29110 3661 3665 PMC4767459__F2 Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer 2475 3667 5728 5163 3091 1975 7248 6009 1977 673 PMC4779598__F5 A proposed model illustrating how SOX4 interacts with PI3K-AKT, Wnt-Beta-catenin, and AR signaling pathways, and how the PI3K-AKT-mTOR pathway regulates the expression of SOX4 in prostate cancer progression 1950 1956 5728 2932 6659 1499 367 PMC4786079__F4 Fever and the thermal regulation of immunity: the immune system feels the heat 6772 6774 3383 PMC4791395__F2 Strategies of Brucella to evade the innate and adaptive immunity 920 114609 4615 54106 4118 7097 7099 PMC4826221__F9 Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells 545 472 995 983 PMC4827226__F7 Working model of how the EphA1-activated SDF-1/CXCR4 signaling promotes EPCs’ homing to HCC neovascularization 619501 8178 7852 PMC4846574__F12 P21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events 998 5879 5062 6714 PMC4852795__F1 Mechanistic target of rapamycin (mTOR) signaling pathway 6009 64798 7249 7248 5163 2887 3667 8660 8408 7942 3643 PMC4868692__F8 Triptolide induces protective autophagy through activation of the CaMKKBeta-AMPK signaling pathway in prostate cancer cells 1152 7249 2475 8408 9474 10533 PMC4870750__F8 Seasonal bias in toll-like receptor (TLR) signalling pathway 4615 114609 5290 8517 3551 4790 8772 10454 3654 7189 51135 6885 23118 9865 5595 5604 7100 5608 8737 1432 3663 54106 5600 3665 9641 7187 6696 1513 7098 29110 3661 PMC4873813__F2 Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism 3630 3643 3667 208 2475 3569 6774 9021 1375 5091 948 PMC4878077__F4 Shows the schematic presentation of the IFNA/B and IFNG receptors linked to the Jaks for the TO-VS-IFN/SAV3 and TO-VS-SAV3 3458 3716 7297 3717 6772 6773 3454 3455 3459 3460 PMC4888770__F1 Radiation induced activation of canonical and non-canonical hedgehog (Hh) signaling pathway 6608 51684 64399 PMC4900950__F3 Signaling pathways regulating Müller glia cell dedifferentiation and proliferation following retinal injury in zebrafish 6774 429 1499 7050 4087 4088 1839 3642 PMC4908701__F5 Curcumin regulated signaling networks 7040 5747 2885 4092 5127 5829 2017 6300 2185 998 3192 867 387 999 5296 6774 2534 1969 3265 8502 9475 5594 10188 4067 2048 56924 81542 4899 6386 3977 2065 5593 5580 5578 3572 2549 23294 5499 1399 4659 6464 6548 9531 1398 3927 9414 5500 PMC4925704__F2 Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives 1499 1956 355 8772 6774 PMC4926062__F2 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer 9837 10714 64785 3777 5558 84296 51659 54821 25926 23347 5411 4939 55388 11169 79892 5557 64858 84081 9667 580 6434 6431 10196 90990 205 4174 4499 27316 26586 23160 4686 6428 6432 26985 1956 1107 10212 57221 3189 3149 54931 3192 51593 64943 10189 57801 54793 23646 84319 378938 10480 51585 140710 51400 410 9244 5002 5480 645 11031 63967 415116 64789 54962 142678 10052 55327 55179 7461 54101 55183 8493 54495 55269 PMC4926062__F4 Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer 1839 1950 7039 2885 1571 10928 572 4513 4318 595 596 PMC4926490__F1 An illustration of the genesis of exosomal aquaporin-2 (AQP2) in renal collecting duct principal cells 359 551 360 361 PMC4928187__F2 Map of lipid metabolic pathways in C 4507 4018 283871 6647 100379198 6319 95 5662 5091 PMC4942931__F9 Pathway analysis using IPA software suggests B3-adrenergic receptor signaling activation in T1D-MSCs, with upregulation of several downstream molecules 2885 2868 156 6714 2922 6774 PMC4951507__F3 Main posttranslational modification events involved in the activation of response to ICLs 472 8554 51588 545 55120 6047 29089 2177 55215 7398 26054 PMC4955784__F1 Molecular and Genetic Inflammation Networks in Major Human Diseases 3636 5581 4582 5170 2932 8660 5728 8539 5411 9261 6194 1956 998 5295 10397 93973 5564 1499 8893 6233 5781 558 6222 1111 2475 8894 5578 3480 1968 1978 6234 3308 8914 6009 6774 1407 1965 7248 7249 6418 5187 PMC4957599__F2 Molecular mechanism of disc cell senescence 545 472 1021 1019 1017 2475 PMC4961213__F3 IFN-induced Guanylate Binding Proteins in Inflammasome Activation and Host Defense 2634 115362 6772 6773 9447 10379 3659 834 2635 79792 3606 10486 828 PMC4968087__F7 ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE 22933 23411 4193 581 142 PMC4969764__F3 STRING v10.0 protein–protein interaction network based on input of 164 proteins of interest 26286 90701 64978 63894 64976 23197 137886 493 65125 6203 27339 22938 1255 8900 22999 320 333 7175 5621 54438 8396 1400 10772 112476 4629 3185 6876 10498 9604 11100 9651 5725 421 5908 9049 7074 84144 PMC4979440__F8 Role of EtOH-mediated cytotoxicity and neuroinflammation in context to HAND via cPLA2signaling in human astrocytes 1571 4513 3576 3553 PMC4997072__F2 TLR signal transduction pathways 3929 114609 4615 7187 7189 29110 3661 929 7099 7098 PMC4999903__F8 Sinularin-induced apoptosis in the AGS and NCI-N87 gastric cancer cells 572 581 2932 2475 2021 PMC5029683__F8 cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer 3611 999 1000 2475 4313 PMC5037829__F2 UPR mechanism 581 22926 7186 1998 468 PMC5043055__F5 Pathways leading to lignin and heteroxylan in maize pericarp at stage R3 1312 790 57608 PMC5045138__F2 During homeostatic conditions, the Keap1 proteins binds with the nuclear factor Nrf2, inhibiting its translocation to the nucleus and the induction of the transcription of Nrf2-dependent reading frames 9817 27035 4094 PMC5047620__F6 Role of Dicer1-Dependent Factors in the Paracrine Regulation of Epididymal Gene Expression 5475 81626 162466 563 4957 3065 83983 56903 199720 317719 5619 150353 PMC5066299__F35 S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway 3553 9817 7018 4318 3383 PMC5067469__F6 The signaling pathways of pathogen protective mechanisms based on HPCNs in Figure in Mϕs and DCs during Mtb infection 7018 1956 7316 2113 6204 4342 1431 693221 PMC5069446__F2 Nutrients-mTOR-miRNA signaling in skeletal myogenesis 3667 4193 29102 9759 3397 PMC5070123__F3 Major pathways affected in cancer- and drug-induced cachexia 161247 2167 33 34 270 2997 5837 5834 5836 5813 2180 35 226 1314 2108 2109 4513 54829 6640 7317 7334 84033 2331 30846 2200 284612 56704 57158 844 3888 3886 3887 3891 4619 4624 85366 8736 4608 7168 5339 7170 7169 91977 2318 88 87 89 7111 29765 4060 4000 5549 PMC5078034__F8 Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy 4193 595 581 1017 1021 1019 545 596 PMC5081730__F1 Epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway 374 9210 2661 1956 2069 685 PMC5086619__F1 Mammalian target of rapamycin complex 1 (mTORC1) pathway and translation initiation 2475 64798 1977 1975 PMC5107940__F7 Proteomic adaptation of small intestinal mucosa in response to dietary protein limitation 1366 9056 7462 54407 PMC5122403__F8 Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation 7099 4615 51135 2475 PMC5133984__F6 Schematic diagram showing the signaling pathways leading to METH- and gp120-induced autophagy 2475 9474 10533 PMC5148003__F1 AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells 4087 6935 23462 51176 4313 59 1277 999 7046 7048 PMC5154531__F6 Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway 1267 4882 4883 PMC5180413__F10 a In tumor cells expressing ERB (MDA-MB-231, MCF-7), Gamma- and D-T3 bind to and activate the ERB receptor, inducing the expression of pro-apoptotic genes such as MIC-1, EGR-1, and cathepsin-D, finally triggering apoptosis 22926 7494 1958 PMC5190135__F1 Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development 1950 1499 9817 56954 7008 595 331 4318 3383 6774 PMC5209821__F4 Working hypothesis of the mechanism through which different miRNAs regulate the PTEN pathway, PI3K/AKT and STAT signalling in sperm 5728 836 5292 596 2997 4609 993 2998 10401 3716 5894 2475 PMC5223135__F4 Proposed mechanisms of kefir peptides-mediated modulation of the lipid metabolism pathway in 30% fructose-induced NAFLD mice 6774 9021 7038 3717 PMC5226501__F1 Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease 4485 9113 26524 PMC5233609__F3 Canonical UPR pathway 7186 1998 468 22926 PMC5261002__F2 Gene network associated with ‘cell death and survival, DNA replication, recombination, and repair' in sPIF-treated EVT 3458 27443 581 3624 596 2896 4838 3569 10533 113026 5333 22976 8740 PMC5266718__F8 Schematic model of the S 1956 1950 387 PMC5295629__F2 Interaction network of the noncanonical NFKB signaling pathway 8615 5903 10024 3895 9919 27333 10238 9456 3092 329 330 79443 4926 653489 2120 27339 331 56616 84861 9342 7188 4150 23219 27429 1859 10615 2802 8239 2339 2289 2181 29110 7186 7187 26227 3182 3329 84188 2342 55294 340120 5966 192111 10549 10131 10155 5970 4790 26056 89941 3301 23770 8402 9093 4670 51602 81887 8604 5955 813 4172 10528 124245 119559 10165 2746 2010 3320 3105 3106 6139 6134 6152 391634 664618 6143 6194 6203 3107 3323 11140 5763 7124 PMC5295629__F4 Interactions of NIK wild-type and mutants 51081 8813 23223 7187 27339 4150 9919 89941 4791 10270 10664 7716 3105 3106 81887 8243 9584 7186 3107 6152 6143 2010 8604 51602 192111 6194 10155 119559 6134 2181 4670 10514 1468 10730 813 9524 79892 9131 6206 79009 11180 6184 6223 3837 5214 5954 2194 11231 4691 23528 3930 79707 10916 79751 23543 9782 7841 84284 64434 8402 3301 4440 10165 11140 391634 3323 3320 2746 5591 6139 6203 5955 23770 10528 PMC5316362__F2 Ingenuity®Pathway Analysis (IPA®) revealed significant overlap between the XDP signature and gene networks related to (A) RNA polymerase II (p = 1.19 × 10−6) and (B) NFKB (p = 1.36 × 10−12) 3207 3206 1616 367 4133 5604 7157 284 8556 PMC5316868__F2 Pervasive translational regulation of the cell signalling circuitry underlies mammalian development 2261 6259 9625 3643 4914 2051 2064 2065 2050 2047 558 7010 10461 7075 5979 2049 2048 4920 4916 5159 3815 4919 4915 5156 3791 1956 2844 2828 165829 387509 64582 27239 81491 54328 2850 23432 2842 56834 54329 283554 80045 56927 160897 151556 2861 57720 1880 2843 9248 11318 3845 3265 5293 5296 6655 2885 5728 107 5062 5063 5058 5590 5581 5579 79884 4294 4216 6885 759 761 5566 5577 5573 5576 5607 4133 9053 5604 4135 5597 6300 5602 5598 5596 225689 PMC5316868__F3 Pervasive translational regulation of the cell signalling circuitry underlies mammalian development 6469 4771 4485 51684 2735 6608 5727 8643 1855 324 2121 132884 1778 79659 26160 23286 60485 3043 PMC5323371__F3 Utilizing a combination of immunoprecipitation (IP) and tandem mass spectrometry (MS) protein identification (ID), complemented by gene expression analysis, a comprehensive Ang-(1-7) stimulated Mas1 receptor signaling pathway was generated 4142 4855 23426 2322 6010 998 5587 2475 4772 4776 4846 PMC5328506__F2 Programmed cell death as a defence against infection 7097 7099 7098 4615 8737 81030 637 581 8772 11035 197259 PMC5328506__F4 Programmed cell death as a defence against infection 7124 8737 114548 3458 8772 11035 197259 3553 PMC5332476__F1 The role of Rho GTPase/Rho kinase signaling pathway in regulation of actin cytoskeletal organization and cellular processes in smooth muscle and non-smooth muscle cells 4018 387 6010 6722 PMC5335607__F3 Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons 960 286 5337 7018 387 2005 5091 5447 PMC5338029__F5 Syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFB and Activin pathways 7200 7040 7201 4087 4088 3547 4089 7252 2488 2492 PMC5341867__F2 TP53 mutation hits energy metabolism and increases glycolysis in breast cancer 2538 57818 92579 5226 2821 5213 5211 22934 7086 5214 2203 8789 2593 2597 26330 5230 5232 27165 2023 2026 2027 5163 PMC5342722__F7 Sulfatase-1downregulates mesothelin and leads to reduction in lymphatic metastasis 7471 10232 6774 572 581 1017 PMC5345234__F4 CXCL5-centered gene network upregulated in astrocytes in response to Meth exposure 81697 5457 186 491 6332 5340 11045 3290 11250 1360 5076 6870 6373 1088 6359 7757 22925 5669 3557 6375 64092 6915 2213 8807 3627 10850 2784 6374 PMC5366136__F4 Relationship between 18 DEGs in network 1 in the Holsteins 84649 79071 6878 9971 6574 2355 2263 11138 PMC5374431__F1a Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks 8674 55690 11231 26088 54623 1460 9616 4150 5728 11198 6749 348 8665 4792 5770 2353 3725 7316 6722 328 1457 7153 6622 2596 1499 7515 1855 7157 5970 4609 1857 801 1107 3065 3320 1856 8841 3066 23411 5371 5048 6689 10284 25942 7343 64426 9221 PMC5382276__F7 A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer 4790 961 23476 PMC5382783__F5 Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics 1431 4015 9536 1548 PMC5385391__F9 HMGB1 release regulated by the PLCG1–IP3R–SOC signalling pathway during calcium overload in hepatocytes 3146 6786 84876 PMC5394545__F5 High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage 54922 84700 3915 126669 10761 54472 8772 3569 114609 3929 23118 6955 51135 920 923 114034 1513 54106 130749 3661 PMC5429546__F4 KEGG analysis of upregulated and downregulated promoter DMGs showing involvement in a metabolic pathway 145226 4507 84920 22856 1890 26330 5625 55301 3706 1621 PMC5431130__F4 Representative schematic of the proposed TRIF contribution to NFKB-dependent TNFA promoter activation 3929 4615 7189 929 7099 4118 PMC5436564__F6 Working model of E2-activated SGK1 involvement in negative regulation of TLR-4-mediated apoptosis and pro-inflammatory TH1 immune responses at the feto-maternal interface 7099 6446 2308 596 331 5617 3662 PMC5448109__F6 Simplified models of ribonucleotide excision repair in Eukarya (A), Archaea (B), and Bacteria (C) 5111 27343 11201 5423 2237 9156 PMC5454413__F2 Proposed regulatory signaling network for HCV entry 1950 3949 1956 655 654 387 3265 3385 659 4092 4091 6955 7436 PMC5460031__F10 IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression 84818 4851 7189 7186 9794 7188 79689 6280 5806 1356 2919 6354 PMC5463358__F3 Microglial M1 and M2 signaling in neurodegeneration, and potential targets for neuroprotection 3458 3459 7099 3460 3566 6850 929 4615 6347 3716 3717 3718 7297 942 6772 383 4513 3146 2932 PMC5467070__F1 Lipopolysaccharide induces apoptosis of hepatocytes via the TLR4/PI3K/Akt/GSK-3B pathway 3929 929 7099 5163 2932 581 PMC5470961__F5 Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis 4089 7124 25805 1616 387 23440 4008 2241 3643 8288 4088 51701 PMC5471278__F3 Interaction network model 1111 7298 5426 672 7204 5578 6117 331 56852 324 5074 1894 10926 51514 11073 63967 11083 29 4055 4175 7153 6241 6240 10519 50649 11186 5888 6648 7132 4782 9320 602 207 4780 4976 5931 641 4722 596 5424 5937 7417 8317 55486 5329 63922 3303 675 51079 51060 7466 10525 9709 2081 1191 56616 1021 891 2305 55183 5557 23649 699 2077 51360 6714 54431 23071 23326 2923 6152 56255 4863 907 1975 10956 5053 PMC5471278__F5 Regulatory network model of DNA replication coupled with nicotinamide 10926 23411 8317 4171 4172 PMC5487527__F2 Links between m6A regulation and cancerSchematic representation of m6A pathway components and targets involved in cancer progression 619501 145258 2305 54890 57721 56339 79923 51676 5914 79068 1999 1956 PMC5487560__F1 The kynurenine pathway of tryptophan degradation 8564 8942 23498 23475 PMC5514692__F7 Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption 28982 571 3162 9843 PMC5520933__F1 The lithium targeted cellular and molecular mechanism by activating several neurotrophic and associated signaling in Alzheimer’s disease 2931 627 351 5978 PMC5529438__F8 Functional involvement of Hh signaling molecules in estrogen- mediated endometrial hyperplasia 2735 5111 1499 PMC5536354__F7 Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes 1950 1956 6010 5076 572 PMC5541666__F1 Details from the STRING interaction diagrams within the global transcriptome profiles of Pink1-deficient mouse cerebellar tissue 10492 84640 29896 57461 11052 26135 10772 79047 91746 64789 51585 84904 54472 25782 26086 109 898 8321 54806 5291 7475 2535 9910 79789 51527 5599 5532 8503 9037 4323 11122 79589 5879 80305 79147 5601 8517 6416 55530 9522 3717 5594 7763 4690 80031 1147 10488 51474 1432 10000 54107 64089 56655 208 207 57210 5425 55750 3661 6772 3836 4792 22808 7529 3845 1540 55203 28232 PMC5547956__F6 Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease 1610 1956 2885 4342 2316 3725 7124 7186 355 1616 4149 929 23118 7189 51295 51701 PMC5547956__F7 Synopsis of significant mitogen-activated protein kinase (MAPK) signaling pathway in the dentate gyrus (DG) of mice exposed to MPTP according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis 8314 4803 627 1950 1956 2885 6722 2316 3725 7124 7186 355 1616 4149 929 7189 51295 PMC5549707__F8 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice 114609 4615 7189 10454 PMC5564816__F6 Ring finger protein 125, as a potential highly aggressive and unfavorable prognostic biomarker, promotes the invasion and metastasis of human gallbladder cancers via activating the TGFB1-SMAD3-ID1 signaling pathway 54941 4088 3397 1000 999 1499 PMC5574319__F11 Signaling pathway changes triggered by HLJDD and its three principals 5266 847 3558 2539 57716 PMC5576060__F1 Insulin and the PI3K/AKT Signaling Pathway Regulate Ribonuclease 7 Expression in the Human Urinary Tract 8471 3667 8660 2475 PMC5577045__F8 Signaling pathways altered by XWL-1-48 355 581 4193 472 7150 3014 PMC5577343__F2 Schematic overview of the 57 meta-signature genes, their literature-based localisation and involvement in the mid-secretory phase endometrium 710 629 347 5047 717 718 722 3484 10578 1675 1672 2878 3600 1356 6947 1803 2028 6424 1604 22943 1908 6696 8714 1942 307 302 360 6505 1969 7103 1910 316 6286 4217 3620 4128 2634 384 4837 10397 36 4495 158471 1382 4496 6990 1647 604 84159 10439 1364 50486 11056 1052 3400 4316 3914 3026 1311 PMC5590044__F6 Schematic of anti-EMT pathway of Rb1 5925 2033 999 PMC5610088__F1 Phospholipid biosynthetic pathways in Streptomyces 4018 283871 5662 95 PMC5622284__F2 Upregulated genes involved in cell cycle regulated processes at 7 days after a single dose of 2 Gy X-rays 699 8243 375 9184 219972 2033 7040 4193 545 5591 472 10744 4089 6502 7529 7531 7532 324 27338 7533 10971 5111 7534 6790 8091 9134 8900 896 891 894 9133 902 85417 890 5347 1164 25 5933 4171 4172 4999 23595 3065 1869 3066 1870 1876 8841 51564 1871 4221 23649 9759 1874 140739 7027 8317 10615 54443 23397 55706 4605 PMC5626664__F4 Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer 1506 1786 1000 999 1378 PMC5655592__F3 The antigen presentation pathway was downregulated in the GF mice 920 6891 6890 100187761 5683 5685 5684 5690 5689 5691 811 2923 5699 5720 213 998 PMC5655592__F4 Intraset concordancy and transcriptome-proteome discordancy of gene products related to protein translation, OxP, and chaperone proteins 6206 6217 6155 6156 6207 5966 3921 6139 5327 6124 6204 1977 6152 6170 6955 4513 6390 6392 367 27000 6737 10130 821 3326 3306 23071 148066 PMC5661628__F1 CS synthesis 22856 337876 64132 64131 126792 55790 55454 79586 11285 27087 51083 PMC5673087__F3 Diagrammatic representation of hypothesized molecular mechanism of LH signaling dysfunction in PCOS women modified from 3643 2492 57706 5869 8091 10413 27324 2627 1586 1583 4763 PMC5675652__F6 Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds 948 3952 28965 1959 9314 6319 57761 PMC5679204__F7 Matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1 961 27035 10811 PMC5697452__F6 Mechanism by which MMP-9 regulates formation of focal adhesion junctions 6714 1956 960 PMC5706051__F7 Diagram depicting epinecidin-1-mediated degradation of MyD88a and downstream events 7099 4615 51135 3654 7189 7187 3661 PMC5707070__F8 Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARGamma-Akt signaling pathway at the early stage of carcinogenesis 572 581 4193 5728 PMC5710670__F1 Clinically relevant inhibitors of the isoprenoid biosynthetic pathway (IBP) (a) Statins inhibit HMG CoA reductase, consequently reducing the entire IBP 3652 2224 5906 998 387 5879 PMC5716761__F7 DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer 7913 2475 7248 999 PMC5725016__F10 Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3) 411 27122 2588 PMC5734789__F8 Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination 388585 3065 4155 PMC5735682__F9 Hypothetical illustration for the role of CWP 2932 324 1499 PMC5736463__F7 RUNX2-I is an early regulator of epithelial-mesenchymal cell transition in the chick embryo 6615 7291 10631 7042 9839 6935 6591 PMC5742900__F4 p53 signaling pathway and related significant changes observed in response to postprandial serum (orange: upregulated compared to fasting serum; green: downregulated compared to fasting serum) 1017 472 545 355 637 8213 4609 94005 4193 64065 10743 2475 5728 7249 3486 64326 6477 PMC5743230__F2 HYPOXIA AND PLACENTAL DEVELOPMENT 3091 2033 405 7428 5230 6513 2056 150684 10370 55662 PMC5745011__F4 Pericytes of the neurovascular unit: Key functions and signaling pathways 7422 7048 7448 84879 4092 4086 4087 4088 4089 331 2932 3516 1000 1499 441478 51176 5243 83483 54567 8829 PMC5748821__F1 Nuclear factor-E2-related factor 2 (NRF2) pathway with a focus on skin barrier function and environmental stress protection 8452 140809 7295 23657 2730 2729 1728 6590 4968 7158 5888 4199 4513 3417 8878 9474 255324 596 1026 9817 9978 PMC5751326__F1 InterferonB (IFNB) signaling pathways and autocrine/paracrine loop 7099 54106 51284 4615 6773 6772 51135 7189 7187 3661 3663 2334 PMC5755497__F11 Ingenuity pathway analysis of differentially expressed genes unique to emerin-null cells during transition from day 1 to day 2 of differentiation 3929 2335 1950 6714 2885 55970 28964 2316 7204 5266 387 998 5829 324 7414 2934 859 2294 23493 26287 55662 57538 4208 4625 7273 PMC5755497__F12 Ingenuity pathway analysis of genes differentially expressed during the transition from differentiation day 0 to day 1 common to emerin-null cells and wildtype cells 55003 472 545 4193 2308 648 4089 4088 4149 993 1017 3084 25942 6839 1050 3627 9547 859 836 55662 91653 3399 51676 3486 26287 285 55796 5925 9750 9325 150572 57159 8651 7128 9021 PMC5770468__F8 Model depicting the suggested signaling pathway modulated by CSs to inhibit HIV-1 gene expression 1431 1956 2885 6714 9261 PMC5778467__F7 Biological pathways that engage TDP1 and TDP2 55775 11284 142 51567 6741 7515 PMC5779689__F2 Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells 51056 2746 9588 7167 6647 1973 3921 283571 3313 3329 10963 2023 5902 5036 6449 10856 6950 10576 6050 5111 7203 811 7534 302 5931 396 7430 301 PMC5781259__F2 Construction and analysis of the HEV-host PPI network 5493 1915 1917 1933 1937 1936 2107 23708 1967 8892 8891 8890 8893 1938 29904 1964 9086 9669 1965 8894 1968 27102 9451 1983 440275 1978 1979 8637 1973 1974 1975 1981 8672 26986 10605 PMC5787431__F2 KSHV LANA upregulates the expression of epidermal growth factor like domain 7 to promote angiogenesis 2335 462 386724 6320 3592 51162 5949 1950 6013 7472 54768 56154 9509 6011 22903 2817 22953 65217 7010 290 10288 1394 8477 5027 1756 221935 22999 6010 51265 29999 1588 144535 1793 10570 814 652991 3214 51804 1745 9314 23026 4808 25925 84072 5080 64321 221458 PMC5789890__F3 Representation of the DNA methylation modifications that occurred within the PI3K/AKT KEGG pathway following 7 weeks of reloading in human subjects 2475 7248 7249 5066 613 5728 572 4199 4193 PMC5818364__F2 Acyl-DHAP pathway of ether lipid synthesis 355 4018 8443 55711 84188 95 8540 PMC5833071__F7 CXCL12 stimulates expression of connective tissue growth factor 6387 7852 5879 4088 PMC5833461__F7 EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection 2146 9474 10533 PMC5836032__F3 Outline of melatonin biosynthesis in the fish pineal gland 56961 15 4199 9575 PMC5855762__F1 The molecular signaling pathways underlying the effects of CC2238/AANP in endothelial cells, smooth muscle cells, and platelets 2695 51083 4509 5728 PMC5856749__F5 NRF2-mediated oxidative stress response –signaling in the nucleus 3725 468 5629 2512 9097 2495 7314 2877 907 8192 5479 10961 316 4094 PMC5861487__F3 TGFB pathway 25805 4089 3458 4091 4092 7124 8454 6500 4052 1874 6667 387 10468 4838 4086 9978 7057 PMC5864196__F3 Potential metabolic capabilities 4553 4118 11113 23440 PMC5872691__F1 One-carbon metabolism and DNA methylation 1719 4548 4524 875 635 PMC5874888__F4 Hypoxia on HIF-1A 847 6478 5163 9361 5033 2475 7428 3099 6197 1490 6576 3939 PMC5881442__F1 Mechanisms for visual chromophore production in the retina relevant to cone pigment regeneration 6121 6120 2147 PMC5902714__F8 Summarized scheme for the regulation of spexin on bile acid pathway 1582 1593 8484 8811 570 8213 3172 25801 PMC5918238__F3 Non-bilayer phospholipids in mitochondrial structure and function 84249 9489 283871 PMC5920792__F2 Feedback Regulation of RTK Signaling in Development 1431 2885 5728 2475 PMC5928506__F8 MSC PGE2 secretion reprograms M1 via two independent pathways to M2 macrophages 54472 4513 2931 PMC5937214__F7 Signaling pathways between palmitate and TNFA for CCL2 production 7099 8532 4615 3654 7189 7186 3661 6347 PMC5945810__F1 TLR2/1 signaling cascade and respective regulatory nodes 114609 4615 51135 3654 3656 7189 23118 10454 7097 3553 PMC5945810__F2 Protein regulation of the TLR2/1 signaling pathway 114609 4615 54472 51135 3654 3656 8651 1540 7189 10206 23118 10454 84166 7097 3553 PMC5982776__F4 The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival 472 545 355 637 5660 30062 5277 2774 64065 3479 5728 7249 100187761 64326 6477 64854 51083 3486 2670 9615 2475 7375 219333 317 581 PMC5986142__F5 Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells 545 7939 64065 4193 4089 5885 2932 6667 6668 5266 9184 1022 1017 4661 472 4118 64853 PMC5987014__F2 Sclerostin and the Wnt/Beta-catenin signalling pathway 4040 4041 50964 1499 324 PMC6006330__F8 BMP2/4 increase neurogenesis from adult hippocampal NSPCs and synergize with WNT3A 51176 650 652 657 PMC6009972__F11 ML141-induced hepatocyte differentiation 998 213 999 89780 7474 1499 PMC6013028__F2 Direct effects of thyroid hormones on hepatic lipid metabolism 3156 2224 1581 1045 8435 574457 64241 3949 1071 64240 4023 PMC6014593__F2 Summary schematic of eye morphogenesis pathways 7204 57619 387 5879 998 6120 PMC6016849__F1 O-Linked Beta-N-acetylglucosamine (O-GlcNAc) Modification: A New Pathway to Decode Pathogenesis of Diabetic Retinopathy 3099 3098 2821 5238 6675 8473 10724 PMC6032409__F3 Signaling pathway that results in the production of tumor necrosis factor alpha (TNFA) in macrophages after the stimulation by lead and lipopolysaccharide (LPS) 929 7099 4615 PMC6053273__F5 The neurogenic activity of (2R,6R)-hydroxynorketamine 627 7249 1938 4803 596 PMC6059749__F11 miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer (NSCLC) through PD-L1 expression via the PTEN pathway 1233 3460 3459 5728 PMC6075432__F14 Sodium fluoride induces autophagy in mammalian mice spleen 2475 9776 55054 9140 9474 PMC6083010__F3 Ingenuity Pathway Analysis of Molecular Activation Based on Gene Expression Profiles(A) Gene expression data were analyzed by Ingenuity Pathway Analysis 7099 5617 3665 3440 3458 282618 100187907 114609 54106 7098 51284 3661 3663 351 6772 4773 57506 64092 5610 59067 23328 81704 6775 8326 142 7052 4615 4843 3659 9242 101180976 5970 8772 8711 84447 54623 3716 6773 8517 2150 1147 83666 3091 4117 PMC6085123__F5 NOD-like receptor signaling pathway 64170 10628 9447 841 834 3606 6772 3603 51135 7297 3716 7099 PMC6096387__F8 Proposed mechanism of JuA-mediated AB clearance 348 19 948 9619 PMC6098897__F2 Schematic diagram for the activation of BMPs, Wnt, and MAPK pathways by phytochemicals treatment 4089 1499 860 9242 PMC6099942__F7 DBTD decreases the intracellular TG by promoting fatty acid B oxidation and inhibiting lipogenesis through blocking the mTOR pathway 22937 9611 5465 2194 51 1579 7038 PMC6101248__F6 BPS-induced placental dysfunction working model 8521 999 8692 PMC6110482__F6 Exposure to nicotine-derived nitrosamine ketone and arecoline synergistically facilitates tumor aggressiveness via overexpression of epidermal growth factor receptor and its downstream signaling in head and neck squamous cell carcinoma 1956 581 999 PMC6111072__F10 Schematic Diagram Illustrates and Summarizes the Role and Signaling Pathway of PAK1 in Regulating Human SSCsPAK1 is mediated by EGF, but not by GDNF or FGF2; PDK1, ZNF367, and KDR are the targets of PAK1 1950 2668 2247 3791 1956 5058 5163 195828 PMC6111868__F7 Signalling pathway by which kallistatin inhibits endothelial senescence, oxidative stress and inflammation 23411 6647 7412 3383 PMC6117929__F8 TGFB1 and E2 cause differential regulation of genes involved in extracellular matrix turnover 4035 1215 8434 2191 2 7980 7058 1803 4318 4313 4323 7077 7076 7079 7078 2006 2335 PMC6117983__F4 Platelet hyperreactivity in type 2 diabetes mellitus 5241 3667 7408 4512 PMC6144451__F7 The effects of CLN3, flupirtine, retigabine, and benzyl (compound 5) or allyl (compound 6) carbamate derivatives on ceramide synthesis and intrinsic/extrinsic apoptotic pathways 355 8772 581 29956 253782 1201 123099 6609 PMC6158072__F23 Nrf2/AR signaling is at the crossroads of Wnt and Akt/FOXO signaling pathways 5728 2932 9817 1499 367 PMC6173361__F3 Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors 10312 3105 2923 8775 3106 567 821 6890 3920 6892 811 5694 5698 203068 6891 8655 11316 1785 9341 PMC6175538__F5 Phosphoproteomic pathway analysis of heat stress induced MET signaling 3082 2885 5829 998 1399 6774 5058 1386 2002 4513 85451 PMC6175656__F3 TRPCing around the Hypothalamus 3717 9021 5163 5443 PMC6189190__F5 The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition 10763 59330 140805 4351 2002 2885 6722 4763 2316 3725 412 7124 7186 355 1616 4149 929 23118 7189 51295 8717 PMC6202145__F1 Structure of hRLX2, hypothetical pathway intermediates of RXFP1/2 and the benefits of hRLX2 therapy in radiation cystitis 122042 59350 387 7040 7079 PMC6209233__F9 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential 5360 4023 7350 3611 7316 364 PMC6222347__F7 Suggested mechanism of action of morusin in MDI-stimulated 3T3-L1 cells and primary adipocytes 1050 355 4099 2056 PMC6230558__F6 TRPV4 activation caused oligodendrocyte apoptosis and demyelination 8532 59341 3553 759 PMC6232757__F1 Representative scheme of the presence of O-GlcNAcylation on glucose metabolism in skeletal muscle 3667 2597 8473 5163 10724 1158 2271 PMC6249275__F1 Natural products activating Nrf2 signaling pathway 9978 9817 19 335 948 9619 PMC6281268__F6 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis 472 545 2932 7465 4661 993 PMC6281268__F7 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis 7124 355 637 4170 581 54205 27429 2021 57448 790 56616 PMC6281268__F9 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis 5091 114034 3717 3383 1325 PMC6305291__F5 Glucose catabolism pathways and transport systems of strain A4B-17 100187907 5805 4841 PMC6305585__F2 ADAR1-mediated RNA editing in cancer development 619501 51582 6774 10904 2556 10983 51684 2735 4151 64506 1719 50652 5091 158471 7046 51773 7054 PMC6315101__F1 Central metabolism in the S 1431 4191 9733 100188821 PMC6319582__F7 Diagram of knockdown of TFPI-anchored endothelial cells induced a more severe LPS-induced acute lung injury via NFKB signaling pathway 7035 7099 7412 59272 7124 PMC6326983__F1 Interaction between reprogramming to pluripotency and tumorigenesis 3265 122953 7528 648 2146 79923 9314 3486 3091 PMC6345631__F1 Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae 4485 60485 9113 26524 55233 92597 857 284119 7003 8463 7004 7005 PMC6349324__F1 Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model 4609 999 1950 PMC6360145__F3 Her2 signaling pathway in breast cancers 9542 2885 3845 5170 PMC6372626__F6 Frequent genetic alterations in genes from angiogenesis pathway in UBC 2064 10818 57211 3265 3845 2475 6774 3091 2247 2260 2261 6714 5335 5336 5829 6654 6655 351 PMC6373401__F1 Neuroprotective mechanisms of antidiabetic drugs in the context of Parkinson’s disease dementia 3479 3416 3554 2475 627 PMC6387020__F5 Representative cardiovascular disease pathway 207 1432 5594 5595 5742 6916 5578 5743 3315 998 6714 842 775 572 PMC6387020__F6 Representative liver disease pathway 5594 5595 1956 2885 2932 5163 572 7157 4790 5970 6256 7186 7124 8717 4318 619501 596 207 100506742 842 836 9817 4780 7296 2475 2549 PMC6388629__F5 Ingenuity Pathway Analysis (IPA) network map depicting the DR signaling changes in HBEpCs after 2 h of infection with IAV H1N1 8742 7133 84890 8717 29110 1616 10010 637 835 56616 596 3984 6709 8743 8738 54627 9053 367 397 PMC6391951__F11 Illustration of most of the proposed modes of action of antitumoral POMs 4693 581 7422 PMC6392285__F8 Calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation 7124 3553 114548 834 PMC6406790__F1 The schematic diagram represents the treatment schedule and the mechanism of NAM neuroprotection in mouse brains 4280 3553 581 596 836 4842 PMC6406872__F3 Structural hotspots and signaling pathways that are essential to the hepatic phenotype of highly differentiated HepaRG cells 5962 7430 50848 100506658 9076 2217 7098 23765 355 7097 998 55327 23513 56288 57530 1499 5584 2035 2200 93643 6711 7408 4074 1956 3339 7414 2817 7170 1525 2050 118429 5792 7171 432 7037 51599 7076 8754 3912 5054 6010 3630 999 1000 3082 10580 4008 5663 5777 27101 6500 8454 9978 51701 6667 1487 3796 PMC6406942__F2 Base Excision Repair (BER) in mitochondria 79661 55247 252969 23583 4968 11284 5428 3552 PMC6436762__F9 Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K 5347 1894 5163 207 2305 983 PMC6441003__F7 Proposed model for the impact of Metformin on FOXO3a and gene transcription in primary human fibroblasts 7249 6009 7248 3569 59067 3552 1843 PMC6445295__F1 Analysis of human inner ear transcriptome over-layed on a generic human neurotrophin signaling pathway 2885 5163 207 PMC6445394__F1 RIG-I, MDA5, LGP2, PKR, and TLRs3/7/8 are activated during viral infection in the presence of non-self dsRNA 57506 11274 103 7098 51284 8772 4615 3661 6772 6773 29110 PMC6471380__F1 Molecular mechanisms of insulin functions and associated modifications in the hypothalamus 7099 9021 27201 6352 468 1234 5728 253260 5140 1363 2840 5443 181 6774 PMC6476043__F1 Proposed schematic representation of the immune response to MERS-CoV infection and how the invading virus is processed during an infection 3558 3569 59067 3565 3586 3627 7099 4615 7189 7187 3661 3665 7098 PMC6485060__F2 CircRNA regulates cell proliferation 2247 1956 3480 103611090 1021 1871 83737 5728 324 867 1499 1017 PMC6488628__F4 The cellular functions of the PLAC8 up-regulated genes 4549 6052 27030 51316 6054 6055 4550 6053 1358 PMC6495097__F8 Model of the Action circSNX29 Competitively Sponging miR-744-Mediating Myoblasts Differentiation 7474 4772 4656 1017 595 PMC6524506__F1 Hydrogen peroxide mediates pro-inflammatory cell-to-cell signaling: a new therapeutic target for inflammation? 7099 5266 4015 3553 PMC6527392__F10 Atypical PKCs control actin cytoskeleton via Cofilin activation 1956 5728 85464 54434 PMC6534900__F3 Summary of the regulation network of Ids in heart development is shown 7474 89780 657 4086 4089 4613 91 3170 2128 55897 6910 6604 3670 3791 2626 4090 PMC6536578__F10 IPA network analyses of the 40 deregulated genes that we obtained from COMPARE analysis (see ) revealed the reconstruction of (A) NFKB network pathway and (B) HIF-1A network 78987 6983 29902 10287 367 8702 22932 6139 PMC6539093__F2 Schematic view of the ERK pathway in response to growth factors, hormones, and mechanical stress 8036 55914 2273 27063 PMC6558065__F1 Proposed MFG-E8 signaling in radial glial cells (RGL) via AvB3/PI3K/Akt/mTOR pathway 5163 2475 894 PMC6558407__F2 PI3K-AKT-mTOR signaling and Metformin targets 3479 5163 3667 7249 7248 6009 PMC6558407__F5 Insulin and autophagy signaling modulation in Huntington’s disease (HD) 3479 3667 9474 9140 PMC6572835__F7 Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma 857 23509 6667 3172 PMC6581447__F2 Construction of the signaling network of cell migration regulators and their classification based on biological functions 5481 2675 10000 1010 122786 3662 5130 10152 10580 3696 5784 7431 9322 3480 3903 25 2774 27 5774 7170 324 3685 1674 8828 998 394 8621 5805 10298 6010 238 23092 6249 345611 8525 57175 118 1452 PMC6612409__F2 Intestinal disease-related pathway including MAPK signaling pathway, NF-kappa B signaling pathway, calcium signaling pathway, and chemokine signaling pathway 2002 6722 5579 5894 5970 7124 7132 3315 4615 3606 3654 51135 7189 3553 8717 7186 7188 929 3929 5743 1909 4923 3356 623 4842 4843 2149 5731 1431 5350 3577 6714 7099 PMC6617169__F2 Signaling pathways involved in the protective effects of tea bioactive compounds against cardiovascular diseases 5728 581 847 7442 2033 23054 PMC6617847__F5 Schematic outline of the salinity-induced response pathway based on proteome, gene expression, and physiological changes in chickpea leaves 4602 4609 551 2922 PMC6626430__F6 Proposed model illustrating the anti-IL-1B activity of matrine 3553 7099 114548 170506 55308 4615 PMC6637205__F2 Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis 4087 4088 4089 6670 6667 4090 4086 26291 652 5104 PMC6637517__F6 Model depicting cascade of the anti-inflammatory effect of ciprofloxacin and levofloxacin, targeting TLR4–MD-2 complex 3929 7099 929 3553 100187761 PMC6637653__F7 Breast cancer cell-based pathobiochemical pathways showing LPHN-induced activation of PKCA, which triggers the translocation of Tim-3 and galectin-9 onto the cell surface which is required for immune escape 23767 2695 100170220 PMC6643215__F9 Schematic diagram summarizing the anti-NSCLC action of butein via activation of ER stress and ROS generation 4280 7494 83939 468 6648 596 581 PMC6652073__F6 Proposed models of the CoQ10biosynthetic pathway in mammals showing two alternative sequences of reactions (the decaprenyl chain is abbreviated as R) 51004 27235 51805 84274 10229 PMC6664075__F6 Hypothetical scenarios for the role of NGF after systemic oxidative stress 4803 2730 9817 PMC6676344__F2 Graphical summary of the anticancer mechanisms of formononetin 2247 3480 2263 7076 7077 6714 6774 5728 581 1017 595 2049 2078 PMC6677617__F4 Shh activates the PI3K/AKT and INSM1 signaling pathways to stabilize and prevent N-myc from entering the proteasomal degradation pathway 429 3642 6469 2932 PMC6685439__F1 Cholesterol biosynthetic/protein prenylation pathway 3652 998 6010 PMC6707613__F9 Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers 3667 847 7124 PMC6710239__F1 Before binding by a Hedgehog family ligand (most often Shh, but also Ihh or Dhh), Ptch1 and presumably Ptch2 maintain Smo sequestered, by a currently unknown mechanism 6608 23432 2736 55764 26160 51684 91653 50937 2619 4036 2735 2737 PMC6711424__F1 CNVs, SNVs/indels on histamine‐related metabolism and signalling pathways 3176 3067 116 7534 5600 5603 6582 638 6300 8673 PMC6714206__F7 Mechanism of PB2 on the protective effect in liver fibrosis 7422 6608 2735 PMC6721639__F1 After interacting with CD154, CD40 recruits and interacts with several adapter proteins, including TRAF1, 2, 3, 5 and 6 958 7188 5970 5971 150365 3569 942 941 79109 PMC6726297__F1 Cholesterol-dependent inflammatory response and cell death in the hepatocyte 3553 7038 355 64241 64240 PMC6732626__F7 In the DP-treated cells, DP preferentially recognized and activated EGFR receptors on the cell surface 107966124 1956 2475 PMC6755424__F7 TGF-ß signaling pathway 25805 4089 3458 9978 8454 6500 7057 7046 387 10468 4838 7124 PMC6780103__F4 Human adenovirus induced cell signaling and downstream immune responses in human keratocytes, highlighting the centrality of Src kinase 4179 7096 10333 7097 4615 6714 54106 PMC6787556__F1 Nicotinamide Adenine Dinucleotide (NAD+) Production and Catabolism in Mammalian Cells 952 120103 84561 6581 93100 23475 64802 349565 23057 8942 10135 65220 4837 23098 PMC6798321__F2 Schematic presentation of Nipah virus (NiV)-induced modulation of type I interferon (IFN-I) production and signaling 6772 7098 117854 51311 51284 23586 57506 29110 7706 3661 3665 PMC6830889__F1 Main TLR-mediated signaling pathways triggered upon stimulation by LPS and LPG 367 7099 7096 6850 114609 4615 4218 54472 114548 2475 7187 7189 3661 3929 3553 PMC6854382__F10 Study on the mechanism of the MPAPO promoting of corneal wound repair and axonal regeneration (A) MPAPO activates the classic Wnt/Beta-catenin signaling pathway through the PAC1 receptor 1499 1021 1019 1869 596 404715 PMC6856900__F4 Gene expression profiles of the PI3K-AKT signaling pathway in treated HepG2 cell 2475 1978 1977 7248 5562 6009 7249 1975 6794 57521 5578 6446 4846 5604 284 2885 6654 3265 5894 3667 2997 5515 5879 117145 4609 595 1017 1441 1440 207 5747 5934 5728 7529 356 200186 9223 10018 23035 598 4515 572 596 5290 1902 468 4170 6256 3164 1147 4790 4602 4193 6202 7099 5106 PMC6862663__F1 Gut dysbiosis/permeability increase circulating LPS and exosomal HMGB1, leading to TLR activation in microglia and the induction of iNOS and superoxide 3146 15 438 5132 6648 196 PMC6899468__F4 Schematic diagram showing the putative signaling pathways for the anti‐inflammatory actions of CST 7124 7186 8717 114548 PMC6904864__F1 Small molecules guiding mesenchymal stem cell osteogenic cell fate determination 3479 1499 4092 4086 PMC6923169__F2 Biosynthesis of N-glycoproteins in eukaryotic cells 56052 51390 10195 79868 29929 84920 2530 2592 51083 PMC6923311__F4 Homology-directed repair pathway determination and its favorable cell contexts 10111 4361 7465 PMC6923859__F3 Wingless (WNT)-signaling pathway as a central way to Braford anti-tick resistant (R) response 7476 2535 7473 8326 999 8324 147111 8507 1857 6934 4041 1956 4609 8313 595 10023 7422 5329 1499 56547 2932 324 5337 7941 3611 5338 466 3082 1230 102 126669 847 2549 6347 7076 652 6502 960 4040 10215 3398 4316 6926 894 6422 3219 2737 PMC6923859__F4 Regulation of immune response as the most relevant pathway in the infested susceptible (S) skin 341 344 4312 12 7076 6774 9021 7297 6347 3716 3717 3976 5008 6776 3265 2885 5879 PMC6927014__F6 Protein–protein interaction and pathways analysis 207 4609 5105 598 5106 51283 2444 1441 2057 3655 5934 63923 7143 3575 3690 5728 7057 5228 7532 4099 7450 3695 7097 3918 4193 3553 7412 7124 27040 472 29760 613 6850 4067 100187907 331 3932 8717 958 7187 26136 7706 3929 4513 84433 6955 4049 4050 PMC6945027__F5 Model for the regulation of the Hippo pathway by Vgll3 and Akap11 395 93663 9411 387 11215 9113 26524 389136 7003 8463 7004 7005 PMC6952997__F8 Influence of ethylene on amount of compounds and expression of genes in lipid pathway in peach 780904 283871 5662 1356 4018 5091 2184 10400 PMC6953027__F1 TGFB Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells’ Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer 9573 2657 4838 2661 151449 392255 3082 627 1950 7124 650 654 652 27302 3976 7040 7042 7043 6997 3977 7189 4091 4092 1499 3725 PMC7005447__F5 Proteomics-guided metabolite supplementation strategy for arRP 3099 5211 2023 5315 5160 2194 2805 4190 1431 717 50 3417 6389 8803 4967 PMC7019052__F3 Skeletal muscle gene expression in Hereford and Holstein-Friesian vs Limousin visualized on the p38 MAPK signaling 8737 6464 8717 7186 2885 5879 4293 5608 1432 8569 3315 9252 4209 6772 1649 3150 PMC7019052__F4 Skeletal muscle gene expression in Hereford and Holstein-Friesian vs Limousin visualized on IL-1 signaling 3553 3556 4615 51135 5781 5295 5296 5335 57161 57162 7189 5590 51295 257397 4214 207 23118 10746 7335 5605 9020 5609 6416 5608 5606 1147 3551 4793 5966 4790 3316 3725 1386 PMC7026191__F3 CEACAM3 signaling connections 1084 6714 3055 64170 8915 PMC7038193__F3 Sp1 mediated tumorigenesis in ovarian cancer (OC) 6714 6667 4193 1364 PMC7047286__F4 Tdh- and tRNA synthetases-derived origins of AI-3 analogs 157739 4553 4151 4397 PMC7056923__F3 Lactate is a signaling molecule in cancer and endothelial cells 57446 2475 1956 PMC7058704__F2 Autophagy regulation under various stresses 6872 2597 64422 4077 9776 PMC7072652__F2 Failure of major homeostatic mechanisms contributes to senescence onset 2475 23411 351 4193 PMC7085230__F7 Mechanisms for the inhibition of SMAD2/SMAD3 and the activation of TET1 signaling by MSTN mutation 2660 4089 4617 4656 PMC7096376__F1 Intra/extra NAD interconnections and NAD-metabolizing enzymes 952 4827 5167 10135 PMC7103699__F1 Schematic representation to highlight the possible mechanism of action by which adjuvants exert their adjuvanticity 7097 3383 114609 9447 115004 PMC7135251__F4 IPA cellular view of: A) 15 affected molecules in the significant Protein Ubiquitination pathway 7345 7328 55031 9958 5471 3309 9097 5688 10273 27000 5704 10477 5702 55284 10393 8178 6502 4838 4026 6497 2885 4091 7189 998 85451 7030 7421 351 8928 864 860 3065 3665 145258 5308 3196 PMC7140344__F1 Melatonin: new insights on its therapeutic properties in diabetic complications 4485 23410 847 2475 7422 581 3667 6850 65018 PMC7177879__F2 Regulatory network controlling SE induction in which the auxin-related epigenetic processes play a central role 382 381 377 7175 PMC7237910__F3 Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2 59272 7113 5478 PMC7247011__F5 Fe deficiency responses in photosynthetic organisms 2242 5091 717 100034700 2241 PMC7268289__F7 Pathway bar plot explanation and pathway map explanation 7124 7097 10333 54472 836 8772 114609 3929 51135 100187907 7189 1513 7098 3661 2475 1977 6009 1975 8544 613 5728 572 PMC7269868__F2 Diagram showing the ER biogenesis pathway for membrane/secreted proteins, highlighting proteins associated with cystic disease 79796 10195 84920 29929 7095 11231 PMC7278240__F3 Brain oxytocin: how puzzle stones from animal studies translate into psychiatry 51393 5021 1956 4889 1938 PMC7290051__F5 Interaction between imaging agents and the blood-brain barrier 213 9356 6564 6565 5243 9429 23456 54977 210 3145 7389 706 10058 5498 2235 PMC7290828__F1 Mitochondrial Protein Quality Control System (MPQC) 65018 27429 4284 115209 10845 8192 PMC7306689__F7 Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3 2260 867 7323 PMC7324642__F2 Humoral innate immune signaling pathways 6693 8772 5966 PMC7330108__F2 Cancer cell death induced by Apoptin 4318 2475 1017 324 596 317 PMC7330666__F2 EGFL6 regulates angiogenesis by activating Akt/ERK signaling 25975 2475 2932 PMC7330666__F3 EGFL6 promotes tumor development by activating Wnt/Beta-catenin and Akt/ERK signaling pathways 25975 2932 1499 8312 324 2475 51176 PMC7334796__F6 Distribution of partial targets of ATR and CR on the compressed pathway 154 1131 5350 4846 1129 3356 2322 3643 3791 3630 7422 2932 2885 6256 3164 596 3551 1147 7189 7124 8717 836 3727 545 PMC7347220__F5 Lyme disease bacterium, Borrelia burgdorferi, stimulates an inflammatory response in human choroid plexus epithelial cells 5197 341 25891 78989 3487 348 23761 2920 6357 4359 1236 3486 26251 3488 6347 6372 22917 629 64108 2921 129607 273 718 1991 11185 8743 3620 8532 8991 116844 2264 64093 50486 254295 26030 56603 116071 4804 127435 5142 260293 85441 3431 4803 10561 3669 1052 170689 3430 7043 770 11274 91608 81622 7089 9636 84875 55647 3434 952 6773 64072 4599 91543 4940 4938 8638 4939 342527 51296 3665 56548 2634 8120 7706 148398 23704 93145 7133 56963 10628 9021 5168 9806 115361 6737 7123 54541 9435 57674 79228 3290 51477 151636 168002 9473 3965 56901 9244 57801 5428 5157 83666 PMC7354691__F4 Interaction network downstream of Atoh7 1277 115708 10592 3070 23246 220202 10201 7764 83992 8569 22823 7911 7469 1314 64895 8189 84545 84950 23759 55847 10063 10163 65117 3652 PMC7397015__F1 Summary of experimental approaches used in identification of major mTOR signaling components 5163 2475 64798 11021 253260 201163 57600 7249 51256 6009 153129 PMC7399735__F6 Gene-to-gene network of Col-0 vs 26523 4883 27161 117159 377 6647 6648 PMC7400965__F2 Difference between SHARPIN presence and absence in regulating the NFKB signaling pathway 8717 8772 7186 81858 PMC7402353__F3 13 major receptor groups involved in itch and their endogenous pruritogens 83737 8989 7442 PMC7405862__F1 Mechanisms involved in organ damages associated with COVID-19 3553 59272 847 PMC7406421__F2 Mechanism of human CoVID-19 infection: 1: infected animals can infect Humans followed by human-to-human transmission through aerial droplets and contact 59272 1401 3569 6347 90865 PMC7414992__F1 LT biosynthesis is part of metabolism of the omega 6 polyunsaturated arachidonic acid (AA), which is cleaved from plasmamembranes by phospholipase A2 (PLA2) 4512 4049 4050 2840 PMC7477297__F3 Hypothetical OT signaling pathways targeting the nucleus and mitochondria in the cardiac cells 6774 5225 1938 4208 2626 2002 2932 PMC7501485__F7 Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways 22926 468 596 581 PMC7504089__F7 Differential gene expression in apoptosis and death receptor signaling pathway in ‘ECACC vs 7124 8742 8743 351 356 7132 4803 8737 8738 835 8717 8772 1616 7186 843 6416 5609 8837 3551 1147 329 330 8517 4793 637 2081 56616 317 27429 596 397 1676 2620 54205 572 581 1677 2354 2353 3725 PMC7510328__F2 MET and/or RON activation, signaling pathway, and biological consequence 3082 1956 3480 2885 1499 5163 324 2475 596 7428 4170 PMC7536854__F2 Intracellular signaling pathways govern cell growth and proliferation 7248 7249 6009 7018 4553 84232 1977 153129 PMC7544989__F10 Ouabain effects in cultured human skeletal muscle cells 6774 6714 476 PMC7555059__F1 Hierarchy of repair pathways choice in mammalian cell 9156 5888 286257 672 5426 7518 7515 675 5893 PMC7557502__F1 Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease 2066 2064 6714 2885 5163 2475 581 PMC7558374__F3 Known functions of FMDV non-structural proteins on immune escape 64127 11258 7187 10010 9140 7186 7189 29110 6772 6773 10379 3661 3665 1999 1977 23394 PMC7564545__F2 Interplay between innate immunity and hepatitis E virus (HEV) 7297 6772 6773 57506 7098 29110 3661 3665 3434 9636 10379 PMC7565866__F3 Micronutrients in one-carbon (1C) metabolism and DNA methylation 635 4397 4524 191 PMC7573470__F1 Life cycle of SARS-CoV-2 and its possible inhibitors 59272 1636 7113 5478 PMC7582884__F1 PI3K/Akt signal pathway, p53 signal pathway, and mTOR signal pathway in NPC 1950 1956 4193 1033 1786 406910 84445 5728 29979 2308 4627 2247 4192 8878 407021 1277 442919 5935 595 100302123 2475 286333 23049 PMC7584116__F2 T cell metabolism by SOCE and Ca2+ signaling 24145 10645 920 814 3662 4609 84876 5225 5465 3091 6515 6513 3099 226 37 6786 57620 8011 PMC7594482__F1 Osteogenesis regulating signaling pathways 6608 51684 860 2308 1499 5741 4920 6259 10023 6010 759 2260 2263 2885 867 2549 4087 4088 4089 6659 PMC7600646__F1 Role of dietary flavonoids in the regulation of the Nrf2/ARE pathway in normal cells 8452 9817 847 PMC7602737__F5 Suggested mechanisms of action of fenugreek on milk synthesis and secretion 5020 3479 3643 2690 5021 207 2475 1447 3906 1374 4023 7360 35 2194 2170 PMC7602998__F1 Events after colorectal surgery leading to AL 4155 2357 27035 4615 3553 PMC7605157__F2 Mechanisms responsible for the cytoprotective and antiinflammatory effects of PARP inhibitors in nononcological diseases 81847 8505 472 3725 2353 6347 6352 PMC7652989__F1 Sphingolipid biosynthetic pathway in plants and the inhibition of this pathway by FB1 6696 8877 95 PMC7660084__F1 Summary of signaling pathways involved in the differentiation of pluripotent cells into corneal epithelial cells 4838 54894 84133 8324 1499 4090 4086 324 4087 4088 4089 7018 PMC7669714__F3 DNA replication restart pathway choice 201973 26073 353497 51455 51426 5557 PMC7680860__F2 Synthetic CO2 fixation pathways for acetyl-CoA synthesis 5066 6120 7086 PMC7680862__F1 Mitochondria-associated ER membranes and cell physiology 780904 10628 5371 5728 90550 7416 4976 114548 10936 51024 56947 2475 717 9217 PMC7688453__F1 ERK and AKT pathway on lymphangiogenesis 7422 7424 2885 4763 5921 10156 5728 5163 5629 2002 4609 7249 7248 466 PMC7705468__F1 Mechanisms involved in the tenocytes during the process of diabetic tendinopathy 1958 2308 3091 633 6662 642658 10682 PMC7708060__F1 Cellular pathways for DNA double-strand break repair 641 9156 142 286257 7518 672 675 5888 5893 PMC7710720__F2 Neurotensin pathway in digestive cancers and clinical applications: an overview 4922 4923 6670 6714 6010 998 2002 1958 PMC7726878__F2 Responses of TLRs to EBV and HCMV 7097 7096 10333 7099 4615 7189 54106 51135 7098 51284 7187 3663 3661 PMC7755285__F11 Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat 2475 999 219699 56998 4616 9314 2786 5336 54961 83667 5519 6446 1026 1944 9076 3306 11211 1969 25805 1844 6195 525 2041 6520 64900 652 8324 64600 239 54566 3985 1609 4092 10162 50848 1364 PMC7770114__F7 Chronic administration of l-DOPA leads to a sensitization of D1 receptors, which maintain the over-activation of PKA in LIDs 2830 7442 2354 2166 PMC7789255__F2 Possible paracrine mechanisms controlling differentiation of spermatogonia in adult testis 5950 2492 64220 339345 9227 6256 157506 346673 54937 216 56603 1382 PMC7790571__F3 KEGG pathway: map04064 27040 472 29760 613 4067 331 8717 1540 10913 7706 4513 114609 4284 4803 4049 4050 5971 PMC7793877__F5 Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema 1453 8864 5519 1408 868 1407 196 5187 3091 3320 9575 4862 5966 1410 2264 4023 23582 282974 1017 5650 3845 7069 5111 1019 7040 115426 4089 6790 5925 4087 288 367 1454 355 3932 55859 9530 51454 1191 4133 2353 3726 467 1649 3727 5602 5970 7124 PMC7810939__F6 GSEA analysis and gene‐pathway regulatory network in the liver 10763 5584 2885 6655 3845 6654 51422 8569 1398 57521 2717 5566 5567 5257 5170 5500 3099 5836 9388 1607 150763 56895 3551 1609 1608 801 224 2194 2002 130 1513 10449 3033 2308 2639 37 8651 1962 35 9470 51 673 3032 1374 5296 PMC7814560__F6 Possible mechanism of Sfrp1-attenuated AMI injury in aged mice 6422 1499 1855 PMC7848033__F1 Role of Osteocytes in Modifying Bone Matrix Properties 5741 1758 1277 50964 1513 PMC7872201__F1 Targets of acetylation/deacetylation in metabolic pathways known to affect I/R injury 50 23410 10449 3030 95 4191 3033 2271 6389 PMC7875638__F4 Network with 11 herbs, 165 active ingredients, 110 intersection targets, and 8 signaling pathways 4313 4342 7290 29 4351 PMC7904922__F6 Photoreceptor metabolic reprogramming: current understanding and therapeutic implications 2597 2936 6647 6648 2806 2805 4190 4118 4199 2744 PMC7909827__F3 Paracrine interaction between Beta-cells and D-cells 3630 114131 6750 2548 759 6263 8450 1642 3087 PMC7911491__F3 Effects of squalene in the NF-ƙB pathway 929 4615 3553 PMC7915495__F3 Protective effects of small-molecule natural products on OS in CKD 2932 1081 2810 2078 23411 23410 PMC7917218__F1 The Unfolded Protein Response (UPR) is regulated by three transmembrane endoplasmic reticulum (ER) receptors: PERK, ATF6 and IRE1A 7186 7494 83939 468 22926 PMC7919585__F2 CoVs on mitochondrial dynamics and autophagy as a quality control axis and the regulatory effect of melatonin.Coronaviruses impacts mitochondrial dynamics and mitophagy 22863 9140 10533 64422 83734 9474 65018 51024 581 4976 56616 27429 2021 PMC7935675__F1 After activation of the S subunit protein on the COVID-19 surface by transmembrane protease serine 2 (TMPRSS2), the virus binds to the Angiotensin-converting enzyme 2 (ACE2) receptor and infects the host cell through endocytosis 1636 59272 545 7113 6868 PMC7962119__F3 Cellular senescence (i.e., permanent cessation of cell division) is triggered by a variety of stresses 596 4303 1021 1019 1017 PMC7982813__F2 Cellular mechanisms and molecular pathways in Müllerian duct development 7476 5076 2018 2263 2885 4090 4086 1602 117154 7018 1761 54361 2625 7484 PMC7999361__F2 Photoperiodic flowering in Arabidopsis, a long-day plant, and in rice, a short-day plant 1407 1408 64326 10938 PMC8018950__F3 Top regulatory effect predicted by Ingenuity Pathway Analysis within Fayoumis at 6 dpi comparison 50943 90865 3394 2353 9619 4783 5601 PMC8023785__F1 Emerging concepts in the science of vaccine adjuvants 7096 7097 10333 7099 7100 114609 51311 51284 4615 54106 7098 3586 3661 3665 115004 114548 7124 90865 5894 PMC8037087__F2 Main mechanisms mediated by cannabinoids on angiogenesis, EMT, adhesion, invasion, and metastasis 4087 4088 3383 1499 7852 2353 1019 3726 3725 6657 999 PMC8038686__F3 Tissue fragmentation and mechanical manipulation disrupt ovarian Hippo signaling pathway and promote follicle growth 4485 9113 26524 PMC8042400__F2 Biosynthesis of VLC-PUFA and VLC-SFA 60481 54898 83401 79993 64834 6785 PMC8044749__F1 Proposed immunopathological roles of circulating histones in sepsis 3603 100187907 7018 4513 PMC8062757__F1 Schematic diagram showing FST modulation of TGFB/Samd 3 signaling pathway during adipose browning 10468 4088 10220 4617 PMC8062762__F4 Summary diagram showing potential points in endometrial cell signaling pathways which may be influenced by BVDV infection 3454 3455 3458 7297 6772 51191 91543 7098 51311 51284 64135 7189 7187 3661 3665 81844 PMC8063228__F6 Regulatory function of peroxiredoxin I on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung cancer development 4512 5052 5111 23035 572 999 5728 PMC8063444__F5 5-HT, produced by TPH2, regulates the serotonergic synapse pathway (a) and oxytocin signalling pathway (b) in the hypothalamus 5582 5742 121278 2561 51764 5020 814 4881 1956 1950 PMC8069026__F1 Illustration of the metabolism of galactose through the Leloir pathway 283209 51083 130589 5236 55276 101448070 7360 2584 2592 2582 PMC8122029__F7 Transcriptome profiling of insulin sensitive tissues from GH deficient mice following GH treatment 8027 10379 1537 PMC8126603__F2 Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19 7098 51284 4615 57506 3661 29110 3665 100187761 6772 6773 10379 8480 4928 PMC8131521__F2 C9ORF72: What It Is, What It Does, and Why It Matters 4218 8408 9776 60673 7942 55255 140775 115004 PMC8143357__F4 Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering 650 4090 4086 4089 PMC8149954__F2 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization 473 6390 4704 374291 9535 6392 4729 6647 6648 2023 3099 PMC8151284__SF1 Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved n-6/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity 355 847 6648 4513 4512 3667 PMC8151958__F2 GSK-3B in the Regulation of Protein Turnover, Myosin Phenotype, and Oxidative Capacity in Skeletal Muscle under Disuse Conditions 3479 7249 1499 PMC8160449__F2 Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection 7113 59272 4077 PMC8165279__F1 Dimming the Powerhouse: Mitochondrial Dysfunction in the Liver and Skeletal Muscle of Intrauterine Growth Restricted Fetuses 4190 2806 95 4191 2271 5091 25874 51660 5163 5164 5165 5166 1431 8803 3945 3939 3420 4967 56901 PMC8165772__F7 Whole-genome resequencing provides insights into the population structure and domestication signatures of ducks in eastern China 2885 126669 5167 PMC8166894__F3 Dendritic spine remodeling and plasticity under general anesthesia 387 998 5879 PMC8168445__F1 Reactive astrocytes are a key component to neuroinflammation in AD 10682 6774 2309 5163 PMC8173116__F2 Monochromatic Lighting During Incubation and Vaccination on the Splenic Transcriptome Profiles of Chicken 3033 114904 7124 1506 64714 PMC8181757__F6 CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline 3630 83939 468 22926 PMC8192809__F2 Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis 5159 4035 19 PMC8195260__F2 Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease 5338 9776 1977 2475 572 7249 7248 6009 3643 1975 5163 6010 5829 1999 6774 PMC8202686__F3 A2B Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis 5879 5163 6010 PMC8206466__F1 Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant 6647 6648 581 596 6774 847 PMC8226943__F2 Redox and Anti-Inflammatory Properties from Hop Components in Beer-Related to Neuroprotection 941 6772 114548 4512 4513 1728 9817 3383 PMC8238692__F1 Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress 7097 7852 7099 969 64127 999 1499 PMC8256363__F9 Novel lncRNA promotes myogenesis of bovine skeletal muscle satellite cells via PFN1‐RhoA/Rac1 5216 387 5879 6722 1499 PMC8275829__F2 ADAMTS Proteases 56999 80070 9509 11174 11093 170691 9510 11096 140766 171019 170689 11173 170690 81794 170692 11095 81792 5045 4035 PMC8276772__F1 Centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation 3717 2056 5008 6356 604 3240 648 9055 11201 10664 80312 2885 4869 10361 672 8648 5728 9611 9612 54880 84525 2475 6010 10562 430 6714 5062 5058 PMC8291349__F4 Regulation of the CYP7A1 gene 4097 7124 3553 6256 7421 3172 3082 9965 2264 5629 23411 1581 1810 PMC8297547__F1 Protein Kinase R in Bacterial Infections: Friend or Foe? 22861 114548 9447 58484 3661 3553 1386 83939 468 8772 PMC8320172__F3 Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients? 1636 59272 1956 2475 PMC8343371__F1 Coronavirus disease-2019: A review on the disease exacerbation via cytokine storm and concurrent management 7113 6868 59272 PMC8348654__F1 Failure to Guard: Mitochondrial Protein Quality Control in Cancer 5066 5550 367 PMC8358957__F2 Endocannabinoid system – current implications for drug development 57406 2166 27163 747 221955 PMC8374068__F3 Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan 3667 3479 2475 581 PMC8382889__F1 Stem Cell-Derived Exosomes Potential Therapeutic Roles in Cardiovascular Diseases 928 975 10085 1956 100133941 116844 967 PMC8391332__F1 Microbiota-Gut-Brain Communication in the SARS-CoV-2 Infection 59272 3627 1401 2475 PMC8393865__F2 Concurrent BMP Signaling Maintenance and TGFB Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear 2660 7043 7040 3625 3624 10220 2662 7042 2657 90 135228 9392 7049 2022 4092 9110 6670 2113 7048 92 93 2280 11171 54472 150094 2648 8848 8850 467 6667 7528 23411 10413 6497 51592 6498 4088 4087 94 7046 91 9372 9146 5520 1601 10131 4089 1490 7057 4256 10468 375616 2331 1634 10048 79674 55914 9618 753 9262 56937 7189 91851 4681 9241 25928 6885 57045 168667 5606 1432 1281 1278 1290 7373 1293 7076 1277 8646 4313 2335 6678 84676 1030 3146 4322 26585 5563 4208 100271849 4205 7019 10891 10454 860 4323 3224 1906 1291 170261 23399 54704 57460 653 650 652 8200 654 151449 655 10140 4091 659 657 658 9765 4090 4086 4093 56963 148738 4920 285704 4593 4617 9507 9759 84085 4656 3399 4487 3397 3398 25805 596 3400 5999 7071 PMC8394812__F1 Evolution of Cellular Immunity Effector Cells; Perspective on Cytotoxic and Phagocytic Cellular Lineages 948 51135 7189 23118 257397 PMC8395761__F2 Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia 54790 2744 586 2146 2475 PMC8415634__F1 Emerging Mechanisms of Wnt Secretion and Signaling in Development 4041 324 1499 6259 387 PMC8415634__F2 Emerging Mechanisms of Wnt Secretion and Signaling in Development 107966124 4218 8724 PMC8424139__F5 Diagram depicts the regulation of retinoid metabolism by PI3K-AKT pathway in RPE 9227 5728 6121 131 157506 5959 6120 50700 145226 PMC8452524__F1a Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs 59272 29110 7187 3661 7098 51284 7113 5045 51311 4615 51135 3654 3656 7189 3665 57506 50507 6774 6868 114548 9021 4015 PMC8452524__F2a Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs 29110 3661 1353 59272 7098 51284 7113 5045 51311 4615 3665 57506 6774 6868 114548 4015 PMC8456978__F2 New insights into the molecular mechanisms of axon guidance receptor regulation and signaling 6868 9860 2048 56963 5979 2674 2043 2668 717 11319 9723 8829 718 10276 6714 1630 23767 6091 6585 351 PMC8459449__F1 Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress 5978 3418 3417 29843 2864 338557 PMC8463866__F1 Production and Function of Endogenous Interleukin-10 in Intestinal Epithelial Cells and Gut Homeostasis 355 836 841 7124 PMC8466012__F3 Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism 64344 6648 3099 5315 5163 6657 79923 9314 4609 PMC8469784__F8 Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview 15 1312 438 PMC8470673__F1 High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats 1636 59272 81888 100 PMC8471532__F6 Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients 9817 4094 1728 PMC8484535__F1 Small RNAs: The Essential Regulators in Plant Thermotolerance 26523 192670 5005 PMC8488354__F4 Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease 1103 6774 2548 PMC8490125__F3 Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases 84973 7503 7099 4615 406938 4513 55384 140609 114548 283131 285987 6023 441951 3553 10628 79792 PMC8508931__F5 Comparative Phosphoproteomic Analysis Reveals the Response of Starch Metabolism to High-Temperature Stress in Rice Endosperm 140805 2582 2875 8540 PMC8513144__F1 Brain as an insulin-sensitive metabolic organ 3667 8660 3479 2475 253260 5163 4899 PMC8526690__F3 Mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues 9780 9242 3240 468 860 9049 1499 50964 4982 5743 PMC8529754__F2 An update on extra-oral bitter taste receptors 5330 29850 119395 255022 PMC8531291__F6 Potential functional mechanism of SIRT3 in heat stress-induced BMECs 51024 4976 55669 9927 23410 581 PMC8533474__F5 Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet 27232 26227 875 23743 1491 2879 2876 25824 215 1757 29958 373156 355 10998 10005 6472 10797 25902 3938 255027 4522 116285 6296 54988 55902 79611 6539 5625 64087 84706 2875 1373 587 217 PMC8534876__F3 Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration 5879 5091 5337 6469 PMC8534876__F8 Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration 6010 3985 25777 23353 581 PMC8541136__F1 Heparanase Regulatory Network in Health and Disease 8074 3082 3553 673 1958 6667 6670 940 10855 7099 100302136 PMC8552375__F1 NAD+, Senolytics, or Pyruvate for Healthy Aging? 2056 5091 367 PMC8576268__F1 Deciphering glial scar after spinal cord injury 27005 7124 8772 PMC8589328__F1 Substrate, intermediates and enzymes involved in the endogenous production and disposal of H2S 635 875 5212 4357 7263 23474 6821 PMC8599992__F7 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability 55247 57697 2067 55215 2177 84464 PMC8599992__F9 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability 2067 84464 128710 80198 146956 641 80010 PMC8602415__F7 Transcriptome analysis reveals that long noncoding RNAs contribute to developmental differences between medium-sized ovarian follicles of Meishan and Duroc sows 7057 3675 3655 3688 3691 3695 4193 PMC8616465__F1 Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas 5893 5888 6741 196 PMC8616823__F2 Cell communication involved in tumour establishment, invasion and immune escape 1116 7124 54106 7097 29121 2857 1378 196 6347 PMC8622331__F4 Bacterial Ghosts-Based Vaccine and Drug Delivery Systems 3929 929 7099 114609 4026 7096 7097 7124 7100 58484 PMC8660205__F6 Network Pharmacology and Molecular Docking Study of Zhishi-Baizhu Herb Pair in the Treatment of Gastric Cancer 6886 930 373073 5728 951 7249 572 4193 51083 4602 5934 5350 1537 351 PMC8695500__F2 Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke 6387 7249 7248 7852 8408 2932 6794 572 581 3550 7054 929 PMC8717932__F1 Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases 581 637 8772 836 64422 5163 7186 10487 197259 79792 834 PMC8741861__F5 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells 2492 6194 1956 1019 PMC8741861__F8 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells 6009 5728 2475 2492 6194 2308 2932 PMC8744729__F2 Ribosomal Protein S6: A Potential Therapeutic Target against Cancer? 5335 25 5347 2932 65975 83939 7428 9001 6135 999 4193 27250 9821 367 1020 8662 8663 5163 7249 7248 6009 6194 1017 1019 1021 5111 5728 11040 4609 8491 55332 54541 1000 6657 3717 6774 2925 1645 1646 57016 5338 5337 8408 23411 51719 51451 471 8493 472 PMC8745614__F4a Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells 1356 5971 9020 5728 1948 PMC8776636__F1 Ovarian Biomechanics: From Health to Disease 2638 3815 4485 1490 2309 5728 8660 PMC8778376__F1 Microenvironmental Metabolites in the Intestine: Messengers between Health and Disease 6510 440 6513 5163 728294 6935 196 324 1499 PMC8784536__F2 Immunomodulatory effects and mechanisms of distraction osteogenesis 4092 4088 4089 PMC8788756__F3 Physiology of Astroglial Excitability 3643 7220 8989 59341 847 PMC8792817__F1 Metabolism and Health Impacts of Dietary Sugars 2592 2582 3795 4351 5373 9942 PMC8796618__F12 MAGEA6 positively regulates MSMO1 and promotes the migration and invasion of oesophageal cancer cells 4105 3156 112950 81857 5469 1025 6873 10923 PMC8799556__F6 Integrin-linked kinase (ILK): the known vs. the unknown and perspectives 3611 253260 5879 998 80895 355 PMC8809122__F9 Epigallocatechin gallate enhances human lens epithelial cell survival after UVB irradiation via the mitochondrial signaling pathway 581 847 2021 PMC8814829__F4 Comparison of porcine milk microRNA expression in milk exosomes versus whole swine milk and prediction of target genes 613 930 5879 8213 7249 572 4193 4703 672 5934 2147 150365 4151 PMC8834222__F1 Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile 31 32 2194 54898 6319 1375 10555 57678 84649 123 64781 729359 10226 5833 3553 4773 PMC8839902__F1 Macronutrients, Micronutrients and Flavonoid Polyphenols in the Prevention and Treatment of Osteoporosis 1499 4087 4088 860 9242 4090 4086 5741 PMC8843787__F1 Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions 4015 4512 4513 5226 5228 6909 PMC8844686__F6 Transcriptome analysis of inseminated sperm storage tubules throughout the duration of fertility in the domestic turkey, Meleagris gallopavo 129607 2635 595 55601 29126 7422 7098 79132 1435 6781 441168 3665 8443 2048 9111 8638 219285 2335 114900 4168 5328 3479 5241 91543 768 94240 3673 3676 10410 84166 767 PMC8853826__F1 Insulin synthesis and secretion in the islet Beta-cell and its control by mirNas 768219 6261 4760 5080 PMC8870141__F5 Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models 7124 7054 1103 PMC8882816__F3 Innate Antiviral Immune Response by Porcine Enteric Coronavirus 7098 51284 3661 29110 51311 4615 57506 7099 7297 6773 10379 3659 6774 PMC8886228__F2 Metabolic Reprogramming, Gut Dysbiosis, and Nutrition Intervention in Canine Heart Disease 948 95 847 PMC8892214__F2 Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review 2057 3717 2056 2623 53335 613 5978 2475 4899 23411 PMC8898188__F1 Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules 51701 6662 1499 2296 2932 324 PMC8898354__F1 Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases 5697 885 23237 PMC8903057__F4 Diverging effects of LMW-HA and HMW-HA in neurodegeneration and AD 3036 3373 7097 7099 960 PMC8912576__F2 Mining of Potential Gene Resources for Breeding Nutritionally Improved Maize 5183 4018 5091 PMC8912926__F7 Potential regulatory network of androgens and progestins regulating testis organization and spermatogenesis via Insl3 1586 367 3640 PMC8913803__F5 Signaling pathways and targeted therapy for myocardial infarction 378938 4485 7481 2056 6772 3716 3717 6774 PMC8953665__F1 Cholesterol metabolism: from lipidomics to immunology 7099 7098 7097 1593 3553 3466 6772 6646 9023 3988 PMC8959454__F1 Drug Discovery of DKK1 Inhibitors 22943 1499 324 10970 1386 3725 387 PMC8977630__F3 Novel Synthetic and Natural Therapies for Traumatic Brain Injury 3146 361 4615 324 3479 627 PMC8987327__F5 Prolyl hydroxylase domain proteins in bone metabolism 23476 1025 80312 54790 PMC8989532__F8 RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences 6010 7006 100124696 22803 PMC8997421__F1 MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology 29102 192670 26523 27161 192669 PMC9001970__F1 Evolving Roles of Notch Signaling in Cortical Development 3714 182 4855 4853 4851 4854 PMC9035186__F3 Signaling cascades in the failing heart and emerging therapeutic strategies 8772 331 23237 PMC9100407__F9 Proteomic Investigation of Molecular Mechanisms in Response to PEG-Induced Drought Stress in Soybean Roots 5091 4190 6389 1431 1737 7360 2821 3417 PMC9101511__F3 Retinitis Pigmentosa: Progress in Molecular Pathology and Biotherapeutical Strategies 8408 9706 178 9865 8717 8772 23118 100187907 257397 79792 PMC9105930__F1 Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart 197259 581 2932 5728 2879 3553 PMC9133562__F3 Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials 5156 5340 2475 PMC9133800__F3 Biological nitrogen fixation and prospects for ecological intensification in cereal-based cropping systems 4609 108348016 80896 PMC9138110__F11 Transcriptome Analysis of Breast Muscle Reveals Pathways Related to Protein Deposition in High Feed Efficiency of Native Turkeys 948 81616 5723 2628 27232 26227 PMC9140571__F9 Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed 1493 962 2534 940 3932 2885 27040 867 3702 8915 1019 PMC9143202__F9 Notch3-Mediated mTOR Signaling Pathway Is Involved in High Glucose-Induced Autophagy in Bovine Kidney Epithelial Cells 9776 64422 4854 PMC9153132__F2 Intratumor microbiome in cancer progression: current developments, challenges and future trends 201633 1499 2191 196 999 541471 PMC9163565__F3 New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain 7099 7124 9573 3479 729230 1524 3553 9311 PMC9170129__F10 Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor in Male Chickens 283869 1392 2832 5443 3725 4158 PMC9178375__F2 Gut microbes and muscle function: can probiotics make our muscles stronger? 5697 8213 3667 3479 3480 8408 PMC9182416__F2 Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin 50507 847 581 PMC9201060__F7 Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression 7476 4040 4041 2147 324 1499 268 269 4089 7018 4086 4313 6425 6423 11197 PMC9204553__F4 CTRP9 overexpression attenuates palmitic acid-induced inflammation, apoptosis and impaired migration in HTR8/SVneo cells through AMPK/SREBP1c signaling 9370 3630 1080 948 2717 5163 2147 7249 6009 95 355 PMC9207250__F2 Vitamin D: A Potential Star for Treating Chronic Pancreatitis 1583 120227 1593 1591 1576 1594 5741 7421 983 196 PMC9209463__F2 Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases 57678 2932 47 2194 31 83401 64834 3638 84532 6319 4047 2224 1717 3422 4598 3158 51141 2222 3157 10682 PMC9227157__F3 Does Abiotic Host Stress Favour Dothideomycete-Induced Disease Development? 6655 2241 6654 55364 PMC9252958__F1 Contribution of specific ceramides to obesity-associated metabolic diseases 10715 2531 253782 91012 204219 29956 79603 1674 6611 51703 84649 95 9350 2581 7368 8879 81537 PMC9255486__F3 Mitochondria: intracellular sentinels of infections 581 115004 57506 8192 22809 3661 PMC9271624__F2 Primary Cilia in Pancreatic Beta- and Alpha-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme 7054 6608 2695 324 6010 PMC9274113__F2 Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases 1178 5891 435 PMC9290242__F3 Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management 1723 3418 2744 10797 6472 4522 PMC9301130__F2 Effect of Lithocholic Acid on the Gut-Liver Axis 8213 9965 7421 7054 6772 6775 PMC9306810__F3 ODORANT1 targets multiple metabolic networks in petunia flowers 1431 717 790 PMC9312354__F7 N6-Methyladenosine Methylome Profiling of Muscle and Adipose Tissues Reveals Methylase–mRNA Metabolic Regulatory Networks in Fat Deposition of Rex Rabbits 57136 364 4023 1523 64848 27250 5728 8491 57721 23091 10231 8773 6774 2308 5106 64102 109 PMC9312479__F1 Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis 10628 114548 23410 65018 2475 7249 1431 5966 PMC9326668__F1 Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease 383 6723 196743 79572 6582 6581 6580 84561 23400 54498 6611 6520 PMC9327256__F7 Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H2O2 enhances their ability to treat intervertebral disc degeneration 581 56954 595 26524 9113 PMC9347991__F2 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate 114548 7099 59272 23411 581 847 PMC9347991__F1 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate 7124 7939 59272 PMC9355645__F7 Transcriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons 1362 7454 79947 3156 4598 PMC9362470__F1 Sulfide metabolite formation and fate 875 1491 192668 4553 847 4357 23474 PMC9368391__F1 RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections 81030 11035 197259 114548 1654 7098 29110 3428 57506 51284 4615 51311 PMC9368391__F3 RNA Sensors in Host Innate Response to Influenza Virus and Coronavirus Infections 8737 11035 4615 51311 114548 3553 7098 29110 10392 57506 51284 PMC9368769__F4 Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases 7189 1611 2932 1499 245972 100187907 1513 126014 PMC9374747__F4 In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states 7018 3667 283871 PMC9380331__F7 Structure and character analysis of cotton response regulator genes family reveals that GhRR7 responses to draught stress 80742 11316 1408 1999 574414 57479 2000 3099 3101 PMC9382911__F1 Pyruvate as a Potential Beneficial Anion in Resuscitation Fluids 2539 5091 367 PMC9398942__F5 Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise 8654 875 847 PMC9408832__F3 Targeting the Sphingolipid Rheostat in Gliomas 7357 64781 57704 2629 166929 259230 6610 6609 55512 55627 392275 2531 10715 253782 91012 204219 29956 79603 130367 81537 8560 123099 427 56624 125981 55331 340485 8879 PMC9468787__F1 Nexus of lipid and O-Glcnac metabolism in physiology and disease 7494 3164 355 8473 10724 PMC9470149__F2 The CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications 3718 3717 2475 6347 729230 847 PMC9471422__F2 Contribution of the gut-liver axis to the immune signaling pathway of NAFLD 1581 8213 9965 23411 5465 3586 114548 7099 3929 929 4615 5861 208 2308 5629 5052 PMC9496095__F2 Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis 65266 26249 8452 65125 PMC9506007__F2 Regulation Mechanism of Plant Pigments Biosynthesis: Anthocyanins, Carotenoids, and Betalains 64326 5091 4602 PMC9529500__F3 Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells 29984 7852 324 1499 2932 659 4086 4090 4093 4089 6469 51684 2735 6608 PMC9544065__F12 Revisiting the therapeutic potential of tocotrienol 581 596 7187 83939 PMC9582522__F2 Brain-gut-muscle axis in human health and energy homeostasis 181 4852 9965 3654 3656 PMC9609612__F12 Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2 9113 26524 10413 PMC9795026__F1 Toolkit for plant lipid engineering: Surveying the efficacies of lipogenic factors for accumulating specialty lipids 355 5091 8288 2184 4018 PMC10033682__F3 Ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway 2872 11188 4313 5916 7454 5914 4320 412 5478 100187761 5045 1445 4145 5786 5447 7971 8576 59272 1269 PMC1186734__F6 Glucocorticoid Receptor-Dependent Gene Regulatory Networks 1981 1163 2872 6046 10062 836 7531 2339 4793 1874 10891 19 5594 133 5970 5468 6772 1622 8648 1869 3175 3725 2619 5105 4609 7124 6597 3931 7528 4316 567 3202 2114 3172 7295 3308 2908 3484 336 3135 5265 5696 8204 3107 3106 4320 10499 3158 5465 5687 10273 5684 PMC155294__F4 Representation of the cell cycle control pathway within TIGR Orthologous Gene Alignment (TOGA) 4193 581 25 472 596 1021 1019 1017 1869 1870 1871 PMC1828067__F7 Osteopontin/AvB3 signaling in the regulation of prostate cancer cell migration 960 6714 6010 PMC1829400__F5 TGFB signaling pathway 8646 9241 4609 1634 PMC2133163__F6 Anchorage-dependent cell growth 1398 2353 3725 PMC2194763__F5 Cell cycle pathway diagram obtained from GenMAPP (Gene Map Annotator and Pathway Profiler, Gladstone Institutes, University of San Francisco, San Francisco, CA [38] 2033 699 7040 9700 5591 545 9184 2932 472 219972 4088 4089 6502 9232 5925 7157 701 1111 11200 4085 7532 1027 991 10459 5111 995 994 9134 8900 891 898 894 890 9133 902 1017 85417 5347 990 999 25 9088 5933 8556 8317 7027 11138 140739 PMC2225983__F3 PI3K-AKT pathway is transcriptionally regulated throughout the lactation cycle 11140 572 6009 2475 PMC2241839__F3 Cholesterol biosynthesis pathway 4598 3156 3158 39 10654 3398 4597 2224 9453 718 6713 7108 50814 51478 1718 10682 6309 1717 717 PMC2242658__F8 Wingless and integration site growth factor (WNT)-induced epidermal growth factor receptor (EGFR) transactivation 6422 7471 1956 6714 1499 PMC2330230__F9 Candidate interactors and their putative postion in the Frizzled signaling pathway 1956 387 344022 324 3065 1385 PMC2359939__F9 Proposed mechanism for RES induced apoptosis in LNCaP and PC-3 human prostate tumour cells 367 595 8178 PMC2566525__F8 Schematic view of part of the IGF-1 and integrin signaling pathway genes transcribed by hNCC 23784 367 572 PMC2575400__F2 MiRNA Signature of Prion Induced Neurodegeneration 6728 7494 3839 836 2120 7326 9802 1356 10477 PMC2586899__F4 The involvement of TNFAlpha-mediated signaling pathways in insulin resistance 3667 7248 7249 2475 PMC2600644__F4 Pathway schematic of significantly regulated genes in (A) NFKB signalling and (B) MAP kinase signalling 7096 3604 943 8795 7132 8797 128178 148022 9618 7187 7185 8717 10293 10758 7189 7188 9020 1326 10892 7128 4794 4792 4795 4790 10125 10235 154 136 998 1847 51562 11184 5871 1850 7786 9448 10746 5595 1432 1843 8569 5608 5597 3725 2353 PMC2635340__F2 Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway 8544 324 5327 847 PMC2639789__F9 Summary diagram of E2 regulation of Wnt/Beta-catenin signaling pathway after cerebral ischemia and proposed role in E2 ischemic neuroprotection 3725 7473 22943 2932 PMC2654411__F3 Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Liver 6256 1576 1558 PMC2654411__F6 Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Mouse Liver 2786 8036 1271 949 727 10592 3606 6667 5573 4801 10051 3660 29128 1956 116 10631 6853 4173 4804 23178 6240 939 874 4999 175 7980 3553 10926 4175 4176 PMC2667788__F3 Paracrine mechanisms in adult stem cell signaling and therapy 3589 3082 3479 2056 89780 6423 10266 10268 6774 3611 572 581 1499 PMC2682636__F4 The comorbidity of HIV-associated neurocognitive disorders and Alzheimer’s disease: a foreseeable medical challenge in post-HAART era 948 920 1234 3416 PMC2686735__F5 Map of BCR-pathway 4067 7409 638 126669 29760 5879 998 2885 10993 3265 5728 2932 572 5603 2002 PMC2692823__F2 Hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem 7225 339855 6786 PMC2694804__F2 Summary of the pathways transduced by the primary cilium 6469 6608 57216 5156 5154 PMC2699768__F3 Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism 5340 6667 405 196 4312 4052 PMC2699853__F1 Diabetes alters the expression of multiple genes of the TGFB pathway (left side of the panel) and BMPs pathway (right side) in rat retinal vessels 7046 657 4851 3224 3460 960 8202 4512 7076 6646 10628 2004 4601 PMC2707763__F6 PROK1 induction of RCAN1-4 and IL-8 84432 717 10887 761 11123 10231 1827 PMC2712749__F1 T cell receptor signalling canonical pathway obtained by IPA obtained in comparison MM8_PM8 27040 2922 55272 PMC2715958__F2 One possible pathway which regulates cell migration in response to strain on fibronectin 5879 6714 207 208 2932 PMC2716801__F1 Schematic illustration of the Warburg effect in tumor cells and in early asymptomatic endothelial cell dysfunction 57103 5163 1892 PMC2732569__F2 The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics 51024 4976 65018 173 PMC2735047__F3 Graft-versus-Host Disease 324 7054 920 PMC2743241__F1 Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents 6608 51684 5972 2932 8445 2737 2736 PMC2754915__F1 Schematic illustration of different pathways of glucose metabolism in cancer cells 8277 2194 3939 5132 PMC2762706__F3 Hypoxia signaling pathway in DM patients 4d post-CPB/C 7428 5034 405 2056 7422 3939 7341 PMC2774790__F6 Proteome Profile of Functional Mitochondria from Human Skeletal Muscle Using One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS 2180 2181 5160 1737 5162 1375 1431 50 1376 4190 4191 37 3421 3418 3030 3032 34 35 36 4967 1743 1666 1891 6389 8803 1892 8801 8802 3028 3033 10449 PMC2778015__F3 Master regulator miRNA of oncogenic and tumor suppressor 596 993 898 26574 472 4193 94241 PMC2778684__F1 Canonical and non-canonical Wnt signaling pathways 4041 23002 387 324 9475 PMC2784807__F1 IL-10 and IL-6 signaling pathways among 2,102 DEG due to IMI with Streptococcus uberis 6774 7054 6955 355 126669 1356 PMC2787730__F10 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway 387 7408 3611 5728 2534 1398 PMC2787730__F12 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cell-adhesion pathway 324 100506658 965 940 3683 58494 3689 1493 3684 3384 90952 7054 920 1003 3676 3688 4267 7412 3695 914 6402 29851 958 6403 214 923 2734 6401 5175 10666 3383 3385 5817 5788 933 6693 PMC2787730__F9 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cytokine and cytokine-receptor interaction pathway 1439 3570 3569 1437 6364 6370 3590 3563 3589 3562 1235 3977 10803 1233 5008 6363 1236 3559 3560 3976 6366 3561 1271 3558 729230 1270 6351 3565 6348 3575 6357 3574 6354 1489 3581 3578 6358 6360 3601 1440 1441 3600 6368 3952 3953 59067 6359 1232 PMC2788213__F4 Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages 7098 57506 6693 PMC2800957__F1 Targets for lithium’s neuroprotective effects 627 4082 572 1499 PMC2808241__F7 Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice 7273 8557 4237 26287 4004 65108 4892 23462 7157 4854 55294 5730 92737 3725 7004 4851 329 22795 5549 2548 4622 4609 3713 2312 6424 2353 5709 2023 5224 PMC2810142__F9 Network diagram of Sp1-interacting proteins 1869 5888 5925 675 6667 1019 6774 6502 PMC2810486__F1 The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections 7097 7099 114609 7187 3569 4513 3603 4615 PMC2815016__F3 Farnesol induces ER stress and activation of the unfolded protein response 22926 7494 83939 7186 468 9601 PMC2815016__F4 Activation of the NFKB signaling pathway by farnesol is related to ER stress 7186 83939 2921 PMC2816169__F6 Prokineticin (PROK1) induction of regulator of calcineurin 1 isoform 4 (RCAN1-4) and interleukin (IL-11) 84432 10887 11123 10231 1827 PMC2819049__F3 Different components of shelterin are dedicated to different aspects of the end-protection problem 25913 545 472 PMC2820477__F1 Schematic junctional organization and Beta-catenin signaling in CNS ECs: comparison of brain and retina 1499 5243 90952 1003 5091 23554 PMC2824707__F1 Tissue level and signalling pathways for PGE2 is presented 1956 4512 1499 PMC2832838__F1 CONVERTING HUMAN PLURIPOTENT STEM CELLS INTO BETA CELLS: RECENT ADVANCES AND FUTURE CHALLENGES 100653366 79923 4838 64321 3170 7852 3172 3651 1950 6662 256297 389692 PMC2834757__F9 Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users 7297 3717 6772 6775 6774 10401 3594 5925 PMC2849843__F1 Schematic presentation of PI3K-Akt signaling 5164 5163 5728 7249 7248 572 7849 4193 PMC2856637__F1 Simplified scheme of early FcERI-mediated signaling events 695 5163 6850 2534 4067 9846 2885 8915 8773 6786 PMC2856676__F1 Comparative Genomics of Flowering Time Pathways Using Brachypodium distachyon as a Model for the Temperate Grasses 80758 574414 55615 878 2000 80742 4440 1407 64326 1999 1408 10278 3397 114034 84232 10938 178 10519 91869 PMC2856900__F7 Moe and Rho1 function in apoptosis based on genetic, biochemical, and subcellular localization data 3725 2353 7295 PMC2861144__F1 Novel targets for the treatment of autosomal dominant polycystic kidney disease 3479 1950 6714 1080 4609 3725 7248 7249 2475 6009 1636 PMC2862093__F6 Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway 2740 3667 5266 5163 5164 PMC2867937__F12 Segment-Specific Neuronal Subtype Specification by the Integration of Anteroposterior and Temporal Cues 100529111 8466 6767 6768 PMC2883790__F2 IGF-I activation of a signaling pathway to mTOR 5266 5728 2475 5163 7248 7249 6009 6010 5879 1977 PMC2885591__F1 With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging 405 7249 7248 7428 6009 3667 8660 64798 64223 PMC2885591__F2 With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging 7249 6009 2475 9610 273 PMC2894844__F7 Schematic drawing of Akt/GSK-3B/tau signaling 5164 5163 3611 2932 PMC2895966__F2 Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target 355 7124 637 841 842 836 7186 8772 1616 PMC2896660__F2 Placing datasets into a functional context using pathway analysis 6229 351 4151 PMC2907698__F4 An example of combined analysis of three identified regulatory modules 4773 572 581 596 673 637 355 6010 805 5728 1956 1846 5111 2885 5613 1386 3727 79866 3725 4149 PMC2909359__F8 Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest 1436 27022 1638 3702 PMC2912804__F7 Role of PGE2 in bridging TLR4 signaling and intestinal tumorigenesis 4513 7099 1956 367 PMC2912833__F4 Generation of a biological network of genes of the most significant Canonical Pathways for the Il10-/- (EF·CIF vs 376497 4513 4794 2494 9021 3455 929 7124 3135 468 6772 3606 567 6891 3109 3123 2212 PMC2919646__F2 Cystic Kidney Disease: the Role of Wnt Signaling 1499 2932 27031 7248 7249 324 166379 79738 7428 585 582 84662 7008 23002 387 5879 8481 85451 PMC2922045__F1 TLR AGONISTS: Are They Good Adjuvants? 7097 7096 7099 7100 10333 929 114609 54106 7098 4615 51284 51135 3654 3656 7187 7189 29110 3661 3665 PMC2928711__F9 Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFKB/HIF-1A activation 207 6667 3717 6774 PMC2930664__F1 One-Carbon Metabolism and Alzheimer’s Disease: Focus on Epigenetics 5981 875 4548 4552 4524 7298 PMC2939633__F1 Chk1 suppressed death pathways 8318 545 472 581 PMC2949386__F6 Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity 3082 2885 5747 5829 5781 5894 1399 6774 3725 2353 5743 PMC2951839__F1 Lower Succinyl-CoA:3-ketoacid-CoA Transferase (SCOT) and ATP Citrate Lyase In Pancreatic Islets of A Rat Model of Type 2 Diabetes: Knockdown of SCOT Inhibits Insulin Release In Rat Insulinoma Cells 5091 38 10449 39 30 PMC2953497__F9 Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells 7288 147463 1493 150094 8819 6648 7178 130340 54 8742 3569 2878 10410 6620 9429 684 7512 11004 8824 54413 PMC2956880__F4 Schematic diagram showing the interaction of the p75NTR and TrkB signaling pathways 627 2549 85451 572 317 PMC2970638__F8 Up-regulation of Paxillin and Focal Adhesion Signaling follows Dystroglycan Complex deletions and promotes a Hypertensive State of Differentiation 355 4149 1431 387 2271 9261 PMC2984239__F5 Merged network pathway analysis of proteins involved in cellular assembly and organization, cellular compromise, and protein folding that were identified in cytoplasmic fraction 80326 11331 3172 22931 51504 55621 PMC2995824__F1 Regulation of muscle protein synthesis 7249 7248 6009 55615 64798 2475 253260 1977 PMC3012148__F2 Biosynthetic pathway of sphingolipids that mediate expressions of genes associated with cellular processes in cancer 10628 4312 1431 64781 1019 1956 51157 581 637 6786 2670 595 5728 10637 2249 PMC3013516__F8 The interaction between cPLA2A and TGFBsignaling pathways in hepatic cells 7040 4087 4088 PMC3016890__F1 The p38MAPKsignalling pathway 998 4600 1386 4149 4208 6772 595 896 PMC3035979__F2 Gene expression profile 5481 5350 3371 PMC3043160__F4 Calcium-mediated mechanisms of cystic expansion 1499 6010 999 PMC3056511__F7 Schematic summarizing the present findings 4803 2475 1977 1999 PMC3072066__F5 Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state 2247 6469 5080 4821 10215 27086 PMC3076924__F4 Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders 6647 83939 22926 7186 468 7494 PMC3090136__F1 Prostanoid biosynthesis and response pathway 4513 4512 5226 5228 PMC3091413__F5 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Asian population 6502 23054 2547 8900 1277 5591 5933 2099 1025 3486 5925 1869 5894 5728 5829 4163 25 8650 6908 4193 672 28514 367 3065 55294 5663 23493 867 10580 1017 3479 1111 6597 4851 5747 2033 4854 1387 5934 331 3714 9794 4609 4331 182 2534 7316 5981 2956 890 5111 2932 4853 PMC3091524__F3 Role of ATR- or ATM-dependent modulation of WRN function in promoting correct recovery from replication arrest 84126 7486 545 11073 472 5888 PMC3091670__F3 Complement pathway 10747 5648 716 717 721 729 730 966 1380 1378 PMC3096079__F1 mTOR regulation pathway involved in hypoxia 2475 1977 7428 2056 PMC3097535__F4 Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities 1356 2150 1501 6147 PMC3101238__F7 Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells 4975 8226 5091 PMC3116046__F2 Increased expression of DNA repair genes in invasive human pancreatic cancer cells 672 2175 2178 2176 472 545 2177 3458 466 675 580 571 4436 5888 4292 2956 4361 PMC3117004__F2 Updated most likely pathway for acylCer formation (November 2010) 84649 7038 6785 PMC3119055__F5 Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events 5069 1588 5340 4057 5327 1803 1622 3482 5328 1634 2308 2475 PMC3120887__F5 MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus 8439 572 4214 1384 6416 3725 1813 1812 1814 1816 1815 23413 5741 PMC3122057__F8 Proposed schematic of the roles of NIK and SMG1 in sensitive versus resistant cells in response to SMC and TNFA treatment 7124 7186 23049 8772 PMC3124472__F4 Proteomic Analysis of Pathways Involved in Estrogen-Induced Growth and Apoptosis of Breast Cancer Cells 8324 64405 6714 7297 1499 3710 5909 5906 5908 983 801 572 7090 864 4397 PMC3127207__F2 Luteolin Effects on Estrogen Signaling Pathway (ESP) Genes 6714 27043 1384 2885 100187907 5241 1655 3484 6597 6908 5106 8829 23426 9612 9611 10498 8841 PMC3131157__F6 Manipulation of plant cell ubiquitin pathway by bacterial pathogens 64781 578 8454 PMC3132181__F1 Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry 472 672 10111 4361 1869 3014 4193 581 PMC3132181__F2 Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry 472 545 995 993 5371 672 983 1017 581 PMC3137639__F5 Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases 1956 5156 2475 6575 10576 1969 6548 27000 23352 2263 6449 23190 10509 7249 84986 253260 85021 23365 23607 91768 2803 23673 10818 4008 10397 8417 23216 3667 9882 1832 84335 6840 572 55605 4659 57447 57446 65125 6929 2309 80025 23367 5311 2975 23774 5208 56257 55677 6672 55074 6194 6046 83860 2931 56478 6938 2932 80153 PMC3142679__F1 Virus reactivation: a panoramic view in human infections 4609 1386 2002 PMC3174190__F2 Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children 6218 4103 7157 1606 6122 9521 7555 10923 3823 4116 9733 6171 PMC3180702__F6 Transcriptional complexity of the mesenchymal-epithelial transition network 2138 5076 130497 2247 2018 2253 3975 PMC3181077__F1 NFKB activation pathways and the impact of S-glutathionylation 3553 5970 5971 PMC3195192__F2 VEGF-VEGFR signaling in lymphangiogenesis 2277 7424 7422 PMC3205276__F1 Biosynthetic pathway of sphingolipids consisting of free long chain bases (top row), which are N-acylated by several CerS enzymes to form dihydroceramides (upper row of octagons) 91012 29956 204219 10715 6611 64781 51083 PMC3213329__F3 Ingenuity pathway analysis of phosphatidylinositol 3-kinase (PI3K) signaling pathway affected by angiotensin II 1356 5728 5163 5471 572 4193 6009 1499 79923 2475 1977 PMC3233666__F1 Adaptation of endothelial cells to inflammatory stimuli and hypoxia 7187 7099 7412 3383 5971 7428 3091 7852 PMC3237753__F7 GAq - Ca2+ signaling pathway promotes actin-mediated epidermal wound closure 1612 998 6010 PMC3240668__F6 Fibronectin - c-Myc network 4312 7422 4280 27283 2492 3611 8570 6124 126669 6223 847 6224 695 2885 1499 4939 5704 9349 6160 6136 3265 2665 324 23456 10577 4478 6138 2002 3192 4172 1877 3185 2023 1316 4335 9112 2521 PMC3241690__F7 Crosstalk between Nuclear Factor I-C and Transforming Growth FactorB1 Signaling Regulates Odontoblast Differentiation and Homeostasis 4782 4087 57154 4088 4089 64750 PMC3246295__F2 Gab2 interactions with binding partners 7173 5894 2885 5163 PMC3253558__F1 Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication 1114 51096 51283 57092 4331 6945 660 7507 6196 54962 1407 84307 6795 2268 9183 57122 6622 4354 5567 57645 5467 54993 10100 5515 5828 1198 7584 9867 8048 387338 65975 PMC3275089__F1 Schematic overview of the ABeta-Cav1.2-ptau-autophagy pathway 858 857 351 255022 PMC3279640__F1 Bi-potential gonad development to either testis or ovary 1761 2516 4216 2626 2260 2254 7490 30812 268 6662 367 6736 1499 284654 84733 54361 50846 56956 2018 1588 10468 PMC3303935__F1 Toll-Like Receptors in Chronic Pain 51284 3576 4615 4049 929 3146 7097 3661 7098 3553 6348 3627 54106 7100 7099 PMC3310197__F7 Interactions of signaling by ER stress, oxidative stress, and cytokines with the pathways of autophagy: Induction of autophagy requires the assembly of Beclin-1 with class III PI 3 kinase (Vps34) and UVRAG 9140 10533 83734 64422 2475 7405 PMC3315606__F1 Roles for prions and protein-only inheritance in cancer 7124 581 595 4320 PMC3317229__F4 P38 signalling cascade (adapted from http://www.sabiosciences.com/) 929 6714 5008 9261 7867 3726 4149 3727 PMC3323563__F8 Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2 993 317 1017 PMC3327724__F1 Heroin metabolic pathway in humans 43 54658 7364 PMC3328638__F1 Glucose, fatty acid (FA) and glutamine metabolic pathways 2539 3099 57103 7086 5163 PMC3328748__F11 The molecular players involved in angiogenesis signalling mediated by the interaction of VEGF-A with VEGFR-2 126669 2885 5894 PMC3334621__F7 IsomiRs and miRNAs target similar biological pathways 1398 2885 6247 4763 2922 5901 3670 759 572 28996 472 545 3725 581 4149 8139 79629 51176 23118 10454 8772 355 23385 914 PMC3334885__F1 T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice 55872 6050 5358 64061 8454 7040 3930 51599 7272 920 11142 1058 10857 51203 PMC3334999__F6 Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation 5728 657 2690 1956 7048 867 174 3845 208 572 4703 PMC3337621__F2 Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation 940 914 5728 50943 3569 5266 4615 4118 PMC3355325__F2 Two distinct DC semi-maturation pathways induce different types of regulatory T cells 999 7124 1499 5971 1236 3586 PMC3356111__F9 Schematic representation of TNF’s dual effect on rat pinealocytes 7124 4792 5970 15 PMC3359655__F1 Central IR/IGF-1 signaling 3480 351 5266 8471 3667 8660 5728 5163 5164 2932 PMC3361623__F3 A New Framework for Understanding IRES-mediated Translation 4397 1939 8562 83939 PMC3363966__F4 Components and targets of pro-phenol oxidase, Toll-Dorsal/Dif and JAK/STAT pathways 1644 8027 7011 4615 7186 PMC3364883__F2 Protein processing in endoplasmic reticulum is altered in Manf mutants 7873 100034700 2922 258010 22926 6667 468 6400 100653365 PMC3364883__F4 Changes in gene expression related to endocytosis in Manf mutants 3949 64798 23440 30844 51028 8027 7873 PMC3367986__F2 Comparative Genomic Analysis of Soybean Flowering Genes 80758 574414 878 4440 2000 80742 1407 1408 64326 1999 54623 10278 114034 84232 178 10519 PMC3372068__F1 Coagulation and complement cascades 718 7018 717 1431 PMC3372917__F1 PTPN11-Associated Mutations in the Heart: Has LEOPARD changed its RASpots? 867 6654 4763 2885 8036 1431 673 5894 161742 7249 2475 PMC3382482__F1 GFPT1-mediated MTOR signaling pathway affected by glucose and fructose in a pTr cell line 207 2673 7249 2475 1978 6194 PMC3383919__F1 Schematic model of the Hippo signaling cascade in mammals 154796 60485 4485 9113 332 374 10207 PMC3390208__F8 Signaling pathway involving CaMKK regulation of GluA1 synthesis and synaptic incorporation as CP-AMPARs 627 5163 2475 PMC3398118__F1 Diagram of the pentose phosphate pathway showing substrates and enzymes involved in it 6120 22934 7086 64080 5631 6888 PMC3399249__F2 Interactions between cytokine and glucocorticoid receptor (GR) signaling pathways 7297 3716 6772 6774 2353 5226 PMC3408431__F8 RhoA GTPase Switch Controls Cx43-Hemichannel Activity through the Contractile System 718 387 6010 PMC3408604__F1 Cardiac myocyte signaling coupled to phosphodiesterase (PDE) 5 7225 6722 2626 PMC3417348__F8 Proposed role of ER calcium underlying early disruptions in synaptic homeostasis at the CA3–CA1 synapse in AD 761 6262 847 828 759 PMC3418163__F1 The two enzymatic pathways generating inorganic phosphate (Pi) as a result of LPA degradation 4099 95 4018 PMC3429092__F4 TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells 7224 759 7225 PMC3430718__F7 SOCS1 regulates the IFN but not NFKB pathway in TLR-stimulated human monocytes and macrophages 7099 4118 3659 8651 3661 PMC3438338__F7 Interferon-Gamma-induced glial cell activation by transforming growth factor B1: A role for STAT1 and MAPK pathways 7040 2885 3716 3717 7189 6772 PMC3439334__F5 WNT signalling pathway map enriched with genes up-regulated in tumorgraft-forming tumors 5328 5340 10454 6714 4087 4088 847 126669 2932 7409 51701 1499 387 998 5879 3985 4316 3265 5058 1977 2475 1356 PMC3444437__F9 C-srcregulating primordial follicle activation and growth through PI3K → PKC → MAPK signaling pathway 6714 2774 6476 PMC3468386__F1 The canonical Wnt signaling pathway 324 3630 1487 PMC3468610__F4 Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing 3845 5898 10928 5900 5728 7074 5295 1147 5293 7157 3717 3082 10000 5170 5970 2263 2353 2885 10818 4312 999 682 4792 5966 5327 2335 637 581 8794 836 8743 8772 1030 7161 4089 5328 5340 3083 3725 5605 4609 10400 6256 5468 PMC3471948__F4 Cross-Species Genome Wide Expression Analysis during Pluripotent Cell Determination in Mouse and Rat Preimplantation Embryos 595 898 2932 4609 4638 91807 5295 8503 5898 9475 6502 4792 PMC3474261__F1 MTORC1 signaling and genetic mutations at specific sites in the pathway 2475 5163 7249 6009 7248 1977 6657 PMC3479160__F5 PPI subnetworks of the extended disease pathways 4738 8883 51107 3028 5664 3416 2597 4595 2932 25825 4436 55851 4437 322 23385 6622 348 4137 2535 8322 54205 2 595 7939 3273 3553 4023 581 7855 2258 10297 8321 5728 208 3725 6934 2257 1870 2241 2251 3479 572 8326 5294 5880 3845 5291 5159 1950 3082 56034 5154 PMC3480485__F5 Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line 545 472 3458 466 580 641 5810 4292 2956 PMC3491909__F1 Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR 5163 5164 5728 7249 7248 64798 253260 2475 64223 6009 6446 5266 PMC3513650__F1 BRCA and RAD52 pathways of DNA double-strand break (DSB) repair 10111 4361 5893 9156 79728 675 5888 PMC3519956__F6 Schematic model depicting how HMW isoforms regulate bone formation 8074 2247 2260 PMC3532379__F3 Functional “DASE” networks 94025 55422 9098 1755 10744 6504 9313 999 PMC3546740__F2 Simplified schematic overview of the biosynthesis of the main secondary metabolites stored and/or secreted by tomato glandular trichome cells 3652 355 412 95 PMC3548163__F2 Modes of action of environmental risk factors for autism at excitatory synapses in the CNS 3479 2863 3480 PMC3554623__F2 Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway 7098 83939 1977 29110 3661 3665 PMC3555235__F4 Predicted pathways by the Ingenuity Pathway Analysis software (IPA) according to microarrays results in peripheral blood mononuclear cells (PBMCs) 6372 2520 6376 6469 5228 27189 80326 8190 80781 7200 6367 3562 4878 3596 23529 7441 924 5663 5798 1813 10855 2906 4855 948 64405 351 624 929 2634 29767 1629 1432 817 329 637 4792 2670 581 331 1536 3315 1386 1387 145258 10365 2908 2547 4222 2735 6772 2002 4193 7538 389692 1409 9616 3159 2072 8602 2294 59343 2128 4772 1786 30813 5914 PMC3562392__F3 Cytoscape diagram of the functional interaction network representing proteins modulation in Pt1 interstitial fluid 4641 51690 10480 1410 6671 338 7431 2244 2243 6708 6710 393 3492 5265 259 213 PMC3565264__F4a Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct 641 5111 6237 472 545 55698 8775 3240 51603 4149 PMC3570385__F1 Signal transduction pathway through TLR 7124 7097 10333 7099 54106 7098 51284 54472 8717 8772 7189 23118 10454 PMC3570673__F6 SIRT1 in the brain is involved in a number of processes that affect neuronal health, neurogenesis, and behavior 5915 6667 102 4128 3064 23411 627 7528 406 9575 3297 4808 PMC3572009__F5 Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients 6359 4922 10747 6364 4485 5997 6282 367 8877 3371 3290 2165 4982 3673 2919 7057 5054 4312 3827 PMC3572136__F8 Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning 7153 10765 10403 1869 6790 50674 595 51083 3569 3397 6772 9021 6774 1870 2261 374 51147 4760 285 1026 5594 5979 4088 4089 673 885 5925 2922 80781 7027 PMC3573758__F2 Development of allergic inflammation 695 8877 4067 2534 6850 9846 PMC3576027__F3 Activity-dependent neuronal signalling and autism spectrum disorder 6722 266743 79800 23237 627 7337 4204 PMC3583298__F7 Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation 3481 472 2973 PMC3595301__F1 Canonical or Wnt/Beta-catenin–TCF/LEF signaling 1499 4920 6259 22943 2932 324 998 387 51176 PMC3607121__F1 Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer 3293 8644 3294 3283 6715 1646 8630 1645 7366 9420 PMC3609760__F5 Transcriptional Profiling of Rice Early Response to Magnaporthe oryzae Identified OsWRKYs as Important Regulators in Rice Blast Resistance 1431 790 1312 1230 PMC3616003__F10 MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators 3739 3741 6495 6331 3939 6324 4208 3759 2626 6722 4624 2627 4625 5308 3751 30819 10265 PMC3616148__F2 Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability 7398 56852 5111 51455 199990 353497 PMC3616148__F3 Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability 22909 2177 55215 80198 146956 84464 199990 2067 51455 PMC3626681__F1 Molecular and biochemical studies in hyperlysinemia patients 10157 51268 501 51166 2639 1892 10449 PMC3628696__F5 Ingenuity Pathway Analysis (IPA) was performed with proteins where SUMO3 conjugation was 2- or more fold up-regulated in any gel slice 9612 861 7341 55553 8535 5371 3188 51588 6612 9782 23435 9063 3185 10915 1107 11100 5094 1822 4665 56001 728343 6663 23132 PMC3632591__F7 RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats 4897 6770 51454 6696 3624 1992 312 2246 1026 25936 79980 9232 9833 58 83540 4085 2950 29127 9212 4605 4172 5350 389 4175 9055 890 283120 4741 1869 4747 4603 7436 80152 26298 5347 4321 1993 1028 666 29968 55872 355 898 10051 675 4193 PMC3632591__F8 RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats 7508 1869 79056 9055 7422 983 83540 7358 5350 1062 7430 6770 3992 1080 351 7067 1950 9833 1894 10592 4313 2950 4311 22974 5367 55959 2246 9118 2770 PMC3633842__F4 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns 7297 3716 6772 6773 10379 4938 4599 5696 3437 3434 PMC3633842__F6 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns 3643 2885 1384 83939 1998 1999 PMC3633862__F6 Interferon-Beta Induces Distinct Gene Expression Response Patterns in Human Monocytes versus T cells 7297 3716 6773 6772 10379 8519 3437 4938 4599 5696 3430 3146 3458 7099 998 6010 5879 6667 7412 PMC3637678__F1 MicroRNAs regulating myogenesis via PI3K/Akt signaling 5728 6722 3479 PMC3640917__F4 Pathway for Death receptor signalling at 24 h post-M 8772 7186 29110 8717 637 56616 PMC3644409__F7 Proposed model showing molecular mechanisms of dysregulated immune pathways in diabetic renal tissues 3565 999 655 9547 6401 4846 85480 4284 3570 7097 7099 3105 6774 3133 7189 8915 6891 2597 2937 4482 1051 6648 2878 847 7351 59307 PMC3652852__F7 Peroxisome Proliferator-Activated Receptor (PPAR) G and PPARA Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders? 5465 847 324 PMC3654985__F4 Peritumoral (P) activated hepatic stellate cells (HSCs) and intratumoral myofibroblasts (T) 5360 10011 4023 1376 7316 472 637 64065 5728 PMC3655383__F2 Importance of white adipose tissue (WAT)–skeletal muscle crosstalk in cancer associated cachexia (CAC) and/or lipotoxicity 7124 50486 948 4099 83939 3667 3569 3570 PMC3659509__F1 Intracellular effects of soluble mediators are mainly mediated through the interaction with specific receptors that link extracellular signals up to modulation of gene expression 1956 5465 2308 389692 PMC3668263__F3 Wnt signaling pathways 324 23002 6010 1499 998 PMC3670289__F3 Differential STAT3 signaling in the heart 5170 3716 6774 4846 2932 2549 PMC3670604__F4 Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma 811 9759 4000 226 1191 4397 3073 3842 7422 3014 PMC3671288__F1 General overview of synthesis pathways for eicosanoids 4513 4512 5091 5226 PMC3674242__F7 Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth 4485 9113 26524 PMC3675375__F1 Wnt signaling pathway in diabetes mellitus 324 1499 4040 4041 PMC3688919__F8 microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model 3218 6469 182 6608 390992 2475 5728 6774 5054 1277 8434 4040 4041 4089 27250 7042 7473 1026 4087 324 PMC3691765__F4 HTLV-1 and apoptotic signaling pathways 367 637 572 581 PMC3694890__F8 Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks 2885 2322 1956 7075 2534 6654 5781 2935 5777 10818 5786 29992 6714 3667 8471 6464 6774 5335 6452 4067 54900 6850 27040 1441 2057 7535 7409 9402 PMC3701226__F2 Signaling pathways triggered by TCR and CD28 engagement 940 5335 10125 8915 7248 10892 5894 1977 PMC3702532__F7 RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation 23265 10580 2319 1398 23433 10603 868 9322 3636 2194 6720 5590 3098 5770 2203 2308 5601 5106 57761 5296 2932 3630 5170 805 5834 7249 7248 5140 5573 3991 6009 5791 3725 3485 2475 6194 57521 3484 9470 3482 5605 6464 2885 6655 369 2353 6513 32 4214 3551 8660 3643 2997 5500 5792 572 6199 3265 5595 PMC3702632__F7 TLR4 and chemokine receptor crosstalk 7099 729230 156 PMC3705163__F8 Schematic model indicating proposed mechanisms by which mutant p53 GOF induces EMT 6935 648 79923 9314 PMC3706396__F6 S100A8/A9 (Calprotectin) Negatively Regulates G2/M Cell Cycle Progression and Growth of Squamous Cell Carcinoma 6279 6280 891 995 1017 PMC3706484__F5 Xenogeneic-Free Protocol for Isolation and Expansion of Human Adipose Stem Cells for Clinical Uses 1839 7430 3002 84824 2057 3134 567 2162 3587 7850 3123 PMC3714263__F6 ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells 5335 2534 2885 4690 3932 7409 3702 4199 4200 27040 945 952 920 PMC3722486__F9 Proposed role of Foxg1 in CM development 4286 7482 4487 5013 6423 51176 595 2297 2290 5080 847 PMC3724417__F2 Signaling Mechanisms in Mammalian Myoblast Fusion 2690 5737 1793 7204 2932 4089 4773 6722 6667 1499 6714 998 4513 5971 10365 9314 7408 7008 2251 PMC3726314__F6 Toll-Like Receptor 4-Myeloid Differentiation Factor 88 Signaling Contributes to Ventilator-induced Lung Injury in Mice 7099 114609 4615 7189 3661 PMC3728221__F8 Working model for the synergistic effect of TPL and ATF on tumour cells 2821 8772 595 6502 836 581 842 PMC3736525__F3 Lycopene induces cell-cycle arrest and apoptosis 3476 3480 3667 1021 1019 2932 637 6502 4193 572 PMC3742001__F7 Schematic diagram summarizing the signaling pathways relevant to this study 2885 7249 7248 PMC3742652__F4 Proposed Twist2 involvment in ovarian cancer 117581 572 596 PMC3747328__F1 The role of K+ channels during cell cycle progression and proliferation 4359 3479 55503 7220 84876 93129 3725 2353 85451 7018 1019 1017 983 PMC3748092__F8 Cell Surface Glycan Alterations in Epithelial Mesenchymal Transition Process of Huh7 Hepatocellular Carcinoma Cell 2530 2517 10317 51083 PMC3768199__F1 Schematic overview of hippocampal signaling pathways following sleep deprivation 5563 27012 9099 51547 5935 5564 2475 761 PMC3773303__F3 Clathrin-dependent and -independent endocytosis of STx 6010 998 6850 PMC3773342__F5 Genes expressed higher in mutant mice revealed networks of interacting genes 5979 3117 972 23764 3108 51665 7538 1959 3725 10563 23139 2028 1958 119 PMC3774073__F1 Phosphorylation events and the modulation of aquaporin 2 cell surface expression 8773 4118 359 2638 PMC3779140__F2 DNA damage signaling at replication forks 11073 3014 9656 545 5884 84126 PMC3779140__F3 DNA damage tolerance pathway (DDT): lesions (yellow Square) in the DNA template blocks progression of high-fidelity replicative polymerase resulting in stalled replication forks 56852 5111 7398 5428 353497 PMC3779140__F5 TLS synthesis in ICL repair by Fanconi anemia (FA) pathway: replicative DNA polymerase stalls upon encounter of an interstrand crosslink (ICL) in DNA 55120 91442 55215 199990 2177 84464 80198 146956 2067 51455 675 79728 5889 PMC3783562__F3 Metabolic actions of Rho-kinase in periphery and brain 3717 6093 5163 6774 2475 2308 4852 181 9021 5443 PMC3785008__F1 Role of hypoxia and HIF2A in development of the sympathoadrenal cell lineage and chromaffin cell tumours with distinct catecholamine phenotypic features 4803 2475 7422 6647 6648 54567 3280 23462 23493 PMC3787652__F2 Differentiation and commitment of IL-17-producing T helper (TH)17 cells in the midpoint of other coacting cells in favor of and against the harboring individual 6772 6774 196 920 149233 29851 1233 1235 6095 23765 643 3662 7018 2625 6778 6775 50943 PMC3787764__F8 Proposed molecular pathway governing multiciliogenesis 2302 4602 4163 PMC3797167__F7 Illustration of the proposed mechanisms underlying the crosstalk between insulin/IGF1 and IL-17 signaling pathways 3479 84818 2919 6364 7188 7186 7189 2932 PMC3798270__F6 The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally 64853 95 43 1636 6389 266790 PMC3810677__F1 Regulation of the HIF pathway by oxygen dependant and independent mechanisms (a) Under normoxia, prolyl hydroxylase domain proteins use oxygen and Alpha-ketoglutarate as substrates to hydroxylate conserved proline residues on HIFA subunits 2475 1906 51129 10399 7428 PMC3814597__F2 General activation of interferonB (IFNB) transcription and induction of IFN-stimulated genes 3716 7297 10379 3661 6772 6773 PMC3814639__F3 Cross-talk between Nrf2 and other proteins 9817 4094 10072 8452 9978 PMC3823407__F8 Proposed model of the effect of crocetin on cardiac hypertrophy, inflammation and fibrosis 2626 4087 4088 PMC3835199__F4 = Transporter, ◊ = Enzyme, ∇ = Kinase, ∆ = Phosphatase, = Transcription regulator, 〇 = Other, = Complex/group, = Peptidase 1778 9265 4899 2782 25896 4534 404217 5142 64324 3064 126626 9967 81565 2035 55835 PMC3844273__F6 Hypothetical estrogen signaling pathways in human cerebral vascular endothelial cells 1839 1956 7018 PMC3849481__F6 Schematic diagram showing CSFV triggers RIG-I and MDA5 dependent signaling pathway to IRF-3 and NFKB activation to promote the production of antiviral and inflammatory cytokines in porcine alveolar macrophages 29110 3550 3661 3553 PMC3858477__F4 Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish 121278 23676 65009 54738 23682 6926 22823 2118 6935 10253 10205 2571 4087 196264 51362 1431 10365 3280 5595 3142 429 3714 4242 10716 121643 2644 1075 3998 22984 58158 92140 114883 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3398 2247 4066 3178 1164 7314 4851 10875 3988 221150 699 991 10733 5443 9045 11065 4312 8836 2668 7272 5111 822 55843 10460 4118 637 9133 157313 899 1870 995 5427 5880 55165 29127 2268 9055 3055 9156 72 26586 PMC3874238__F2 Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism 100170220 7124 5728 9021 2885 10938 1398 3667 2534 23301 5163 434 2887 23216 5140 7249 7248 572 6009 1977 2549 PMC3875403__F6 MDA-7 interferes with tumor promoting pathways 331 5163 2932 2931 5728 PMC3875676__F4 High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells 65975 4609 3845 2064 1956 PMC3877547__F9 Schematic model of cancer-derived IgG to enhance cell growth and proliferation through inducing the production of a low level of ROS 5052 10399 5901 847 PMC3879372__F10 Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells 3586 5336 6714 6786 3662 PMC3897553__F8 Neural Epidermal Growth Factor-Like Like Protein 2 (NELL2) Promotes Aggregation of Embryonic Carcinoma P19 Cells by Inducing N-Cadherin Expression 1000 4753 6667 PMC3905242__F1 MRE11 complex: starting from the ends 4361 472 641 545 993 995 1017 983 PMC3913901__F2 cIAP1/2 regulation of TNFAlpha-induced canonical NFKB pathway activation and suppression of default death pathways 841 5970 197259 8772 8717 7186 10487 10486 PMC3917856__F6 NRF2-KEAP1 Pathway Is an Early Responsive Gene Network in Arsenic Exposed Lymphoblastoid Cells 3725 468 7415 9097 7314 10963 2512 9709 10574 2326 8192 5479 10961 2495 847 2877 10058 2052 7295 2729 2730 2936 873 316 PMC3918721__F1 TGFB signaling and MMPs interplay 4050 7939 126669 6010 PMC3919568__F7 Integrated metabolic pathway of BCAA metabolism 8501 8140 587 594 593 1738 1629 36 34 1892 64087 56922 3030 3032 549 38 18 5096 23417 5095 84693 64064 5019 3155 PMC3921899__F1 Lipid signals and insulin resistance 5091 5163 2180 137964 84803 150763 253260 4018 2475 10554 56894 10555 56895 55326 2931 2308 8694 84649 PMC3940969__F1 Cytokine signaling pathways in brain preconditioning 729230 54472 4615 7189 8717 7186 6347 PMC3942330__F3 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms 6387 7852 387 9475 6093 836 9826 PMC3942330__F5 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms 1956 6714 998 23616 23607 834 7410 PMC3942330__F6 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms 2047 5337 8844 5911 23043 5894 57826 387 999 PMC3948174__F1 Regulation of G protein-mediated signaling by RGS2 in the heart 25801 5225 5997 PMC3952878__F4 FAK functions in cancer stem cells 4040 4041 6469 960 324 2932 1499 2475 79923 6657 4609 PMC3962840__F5 Relationships between the cellular signal pathways in HAdV-36 infected human muscle cells 3720 10955 9781 79172 9945 4174 1870 23594 144455 1844 55388 79968 57162 55038 5317 5806 3872 64770 PMC3982454__F8 CD44 protein-protein interaction pathways were performed by String 9.0 Web software 960 2308 4193 3320 7249 5728 7316 2932 7015 2475 5763 PMC3989895__F2 Simplified pathway map of CCN1 and CCN2-dependent outside-in signaling pathways regulating endothelial cell function and behavior 3491 1490 10983 4035 4041 4036 4037 4038 4040 6714 998 5894 652 51665 1956 PMC3994550__F1 Insulin signaling pathway 3667 8660 5163 5164 2475 1977 2308 PMC4000313__F2 Death receptor signaling and programmed necrosis 637 8772 8717 PMC4011580__F6 SCFBeta-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway 5728 4734 9978 6500 PMC4014927__F2 Summary of statin‐mediated peroxisome proliferator‐activated receptor G (PPARG) activation in macrophages 6010 998 19 PMC4028208__F9 A summary schematic of the lansoprazole-induced AhR/Cyp1a1/Nrf2 pathway in the liver 196 1543 54578 PMC4043871__F2 Testosterone signaling pathways in Sertoli cells 1956 6714 367 PMC4047858__F7 Combined metabolomics–transcriptomics identification of pathways affected by MPP+ 6098 26227 29968 5723 875 1491 6472 1719 7298 10797 PMC4050365__F5 Single-stranded RNA loading to AGO-clade Argonaute proteins 29102 54487 27161 5073 PMC4052099__F1 Predicted insulin signaling pathway in schistosomes based on the characterization of schistosome insulin receptors, the published S 867 2885 2475 2308 PMC4057899__F8 Schematic diagram 3553 5020 1950 5021 1956 PMC4059820__F2 Signaling through T1R2/T1R3 in type II cells of taste buds, in the gut and in the B cells of the pancreas 2821 5330 29850 PMC4060285__F6 Schematic showing the protein acetylation sites in metabolic pathways that are most differentially acetylated in LDKO/flox liver 5236 7360 2998 55276 3099 2645 2632 2821 5836 2203 5211 54995 2194 229 226 7167 230 2597 27349 5232 669 23417 5223 5224 2023 2026 3945 2181 2182 5315 55902 4190 5313 3939 3417 48 1431 387569 50 35 33 37 36 4191 3030 3033 3032 2271 4967 1738 6389 8802 8803 1743 PMC4064789__F8 The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer 1950 1956 5111 PMC4068281__F3 Signaling pathways and transcription factors supporting or affecting the barrier phenotype of CNS-ECs 2534 4067 6469 1499 54345 6670 2078 7080 1728 PMC4071053__F3 Interferon Signaling Pathway identified by Ingenuity software 3458 6773 6772 8554 10379 581 3659 5696 6890 3437 3430 PMC4073278__F7 The changes that are induced in cells by a deficiency of RPs 100 545 472 1633 2475 PMC4073990__F4 Schematic description of the signaling pathways known to be activated by CCK1R and CCK2R 1956 1839 6714 3717 6010 3667 6774 2885 2475 5311 1398 PMC4074399__F1 Cell Death Pathways 7186 8717 8772 637 581 317 PMC4075250__F5 Ingenuity network analysis of differentially regulated labeled-pairs 4025 4155 2904 6517 9615 6857 1267 5478 7533 3939 6622 5594 375 4609 PMC4077471__F3 Examples of pathway engineering and combinatorial biosynthesis to generate new analogs: A 1636 7006 100124696 3034 PMC4084927__F10 Acetaminophen and NAPQI are Toxic to Auditory Cells via Oxidative and Endoplasmic Reticulum Stress-dependent Pathways 22926 83939 7494 468 PMC4085722__F2 Regulation of protein trafficking, receptor signaling, and protein clearance by ubiquitination in Alzheimer's disease 26232 324 999 891 351 55294 4193 PMC4111847__F4 Glycolysis and the triacylglycerol biosynthetic pathway in Cp0710 2821 27349 2597 PMC4115620__F6 Pathway analysis for H3K9me3 enriched genes in baboon SVZ cells 7428 5034 472 4193 5728 405 55662 10987 3939 7341 2056 7422 8440 253260 3611 6251 7016 998 2475 4666 51176 6010 4318 650 PMC4118962__F1 Interleukin-1/Toll-Like Receptor-Induced Nuclear Factor Kappa B Signaling Participates in Intima Hyperplasia after Carotid Artery Balloon Injury in Goto-Kakizaki Rats: A Potential Target Therapy Pathway 51135 3656 4615 7189 23118 PMC4119864__F3 Signaling epicenters: The role of caveolae and caveolins in volatile anesthetic induced cardiac protection 859 6714 857 1445 PMC4123083__F8 The miR-203-mediated regulation network for skeletal muscle cell proliferation and differentiation 9794 4208 4854 7157 PMC4127169__F2 Wnts organize presynaptic (CNS and NMJ) and postsynaptic (NMJ) specializations through multiple signaling pathways 4593 5879 2932 1499 474168 PMC4130902__F1 G-protein—coupled receptors, hedgehog signaling and primary cilia 6469 23432 7289 2735 PMC4131284__F6 CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11p110 472 672 5371 1869 PMC4142049__F3 LOX-1 signaling mechanistically links atherosclerosis, hypertension, and diabetes 367 2475 717 23411 PMC4143117__F7 Dynamics of BMP Signaling in Limb Bud Mesenchyme and Polydactyly 6662 1297 1280 PMC4143615__F2 Top-ranked enriched canonical pathway identified using IPA, the T-cell receptor signaling pathway 7006 100124696 2534 7535 6461 3932 2885 867 1445 27040 3702 2922 1384 5778 2002 PMC4146087__F2 Interaction of drug and signaling pathway in relevance to depression.Sex steroid hormones serve as an example 627 6957 2549 PMC4147234__F1 Infectious tolerance that depends on a nutrient depleted microenvironment maintained by Treg cells within tissues 50943 2475 7166 383 586 157739 3067 PMC4158873__F2 O-GlcNAc and cancer metabolism 5163 2475 8473 2597 5230 2023 3939 9997 2744 355 PMC4158873__F3 PI3K/Akt/mTOR signaling pathway 5163 5728 7249 7248 6009 8473 253260 2475 1977 PMC4173780__F1 Strategies for the production of linear, primary alcohols 3045 100187828 1401 8772 196 100187761 PMC4179136__F4 Perturbation of the MAPK signaling pathway at 9 h after MPP+ treatment 1147 1610 4137 4803 627 5578 673 1950 1956 6722 22800 4342 4609 11221 2122 4775 3725 836 4149 10296 51295 3611 5566 3952 6654 2353 4763 2316 1398 11072 355 7046 929 51701 PMC4179136__F5 Perturbation of MAPK signaling pathway at 24 h after MPP+ treatment 1957 4137 673 2353 5154 6237 6722 2005 4609 1845 2316 2122 3727 4094 1386 836 7186 355 1649 1616 4149 468 51701 1147 1950 100188864 5156 4342 5778 11072 1398 3725 7818 7045 7046 51295 3792 PMC4179136__F6 Perturbation of ER protein processing pathway at 24 h after MPP+ treatment 821 811 10113 7841 1409 9373 7415 258010 602 22926 51009 1649 22872 23193 10134 1629 10273 PMC4183711__F8 Diagram depicts a model in which Eya2 and Ebf3 are positioned in the gene regulatory pathway for the development of RGCs 388585 3280 5080 220202 6664 6659 2139 5458 3670 7088 3175 253738 PMC4184971__F4 Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention 8737 7341 1616 8772 637 6416 331 4926 90427 581 790 PMC4191885__F5 Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain 6469 2625 2735 2736 3170 PMC4197746__F1 Upstream of mTOR: classical and non-classical inputs 4040 4041 3667 2887 5879 5728 5163 64223 324 2475 2932 253260 7249 7248 51256 6009 8408 PMC4197746__F2 mTOR controls metabolism 64223 8408 22863 790 5163 3481 PMC4226164__F1 Damage-associated molecular pattern signaling mechanisms 114548 4615 998 3553 717 PMC4227521__F1 Erythropoietin receptor and signaling pathways 2056 6772 2885 126669 6774 694 2057 PMC4234693__F2 Three Wnt-dependent pathways have been categorized: canonical Wnt/Beta-catenin and non-canonical Wnt/PCP as well as Wnt/Ca2+ pathways 2932 387 1499 324 PMC4234693__F5 Influence of MAPK signals on the Wnt pathway 2932 1499 324 6662 PMC4241130__F2 Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach 95 34 10449 30 10993 549 176 3033 81616 28965 PMC4250176__F6 MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells 100187761 3611 5728 PMC4253420__F7 Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERA and STAT5 5617 3717 5618 6667 PMC4253612__F3 Genes in cancer-related pathways 6714 1956 2885 3265 5894 1893 4318 4609 22809 2932 1499 7042 324 7124 4791 PMC4256277__F2 Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway 9805 6714 85462 23321 10458 84722 79145 5827 4647 83871 128387 9595 57617 64098 81614 6165 137872 26275 7019 1376 57799 4528 57222 10938 51805 2475 79058 79073 56910 58504 57171 6010 5768 80270 56903 9754 51291 790 PMC4256277__F4 Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway 4041 4040 9572 79980 2806 84722 9754 10287 10458 10938 2224 80764 55734 83871 58504 3965 80270 4245 1763 6714 57544 57171 23516 79058 57602 7090 10629 23321 1240 389125 29927 57222 PMC4264574__F1 TLR4 signaling cascade 3146 929 4615 114609 3661 3603 3665 7099 PMC4267650__F6 The roles of the RuvBL1-RuvBL2 complex in regulating the FA DNA repair pathway 2475 8295 472 3398 23049 545 8607 10856 PMC4271318__F8 FGF signaling specifies hematopoietic stem cells through its regulation of somitic Notch signaling 2264 51384 1738 PMC4271744__F1 Network analysis of genes significantly modulated in response to mood stabilisers 2885 3265 6670 2099 3727 PMC4278286__F4 Altered metabolic pathways in clear cell renal cell carcinoma: A meta-analysis and validation study focused on the deregulated genes and their associated networks 3485 3486 7076 2335 7422 949 19 5359 6557 2321 7097 929 7827 6569 3988 230 5163 7431 2026 5696 226 6676 5698 229 6667 6774 3091 6772 3975 2104 768 79365 694 2625 30846 PMC4285816__F6 A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS) 7186 4703 6774 3725 466 PMC4287105__F3 Example of difference between LW and MS at fetal gestational age 110: pathway of Gluconeogenesis 3099 2645 2821 5214 229 230 2597 3939 5224 2023 5313 5106 5091 25874 1737 1738 PMC4287682__F1 MiR-15 family and its targets in the INSR signalling pathway 6810 3643 867 2549 1398 5728 3667 57521 572 2887 1977 47 PMC4301880__F1 Experimental design 93183 54965 284098 9487 5277 54872 55650 5283 8818 51227 10026 94005 51604 128869 8733 54344 8813 23556 9526 5281 84720 9488 27315 PMC4310451__F3 Differential effects of leptin and adiponectin in vascular endothelium 1401 79602 8660 3717 6774 7412 PMC4319960__F7 SMAD-Independent Down-Regulation of Caveolin-1 by TGFB: Effects on Proliferation and Survival of Myofibroblasts 4087 4088 857 PMC4334750__F6 Theoretical model for metabolism of alcohol in the brain 84706 2746 2907 80852 PMC4336821__F7 Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis 1019 894 5932 11183 637 5915 6256 PMC4339543__F2 The Role of the Protein Tyrosine Phosphatase SHP2 in Cardiac Development and Disease 3643 6714 2549 387 2885 PMC4342024__F9 GPCR-mediated PLC/PKCB/PKD/SSH2 signaling pathway to regulate cofilin activity 5330 5331 85464 PMC4344212__F4 Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing 3280 3175 50674 6928 4760 389692 5080 4821 3110 3087 3170 3375 2645 3172 4825 6514 5313 3174 3171 836 3651 5664 5078 8883 3606 25825 2494 351 7124 55851 3028 4311 23621 2597 PMC4367964__F5 Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta 7099 29108 114548 148022 4582 1642 6199 6615 3606 837 23020 9391 834 3553 3146 942 4312 4314 3684 PMC4369672__F2 Simplified overview of the RA-associated inflammation-promoting factors 27122 6423 6424 7474 3553 89780 100187907 4920 PMC4373477__F1 Simplified diagram of the Ras/ERK pathway and SST effects through PTPs, SHP-1 and SHP-2 6750 2885 7249 7248 6714 466 595 2002 PMC4373477__F2 Simplified diagram of PI3K/Akt pathway and SST effects through PTP SHP-1 6750 5163 7249 7248 572 595 581 PMC4373664__F1 Canonical Rho GTPase signaling motifs regulate actin cytoskeletal dynamics 5879 998 387 5063 5062 5058 752 23002 PMC4376959__F2 Sphingolipid metabolism 64781 8877 56848 253782 29956 204219 10715 79603 91012 PMC4379579__F9 Fate of plasmids and their expressed antigens after electroporation (A); The Fas/FasL signaling pathway and some of the key molecules involved (B) 324 920 355 8772 PMC4381588__F1 Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma 1984 389421 4613 PMC4394589__F6 Regulation of genes in IL1/TLR signaling pathways 3603 9021 1540 6761 90865 114609 3654 7189 51135 4615 54472 929 29110 7187 3661 PMC4401129__F1 Tie2 (Tie2 tyrosine kinase receptor) structure and Ang-1-Tie2 signallingsignaling 383 7975 5340 5879 PMC4404103__F2 RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats 6513 3099 5213 2821 226 8789 5230 2597 5224 2027 9123 5315 3939 3945 6566 4191 1431 50 2271 3418 3420 3421 3419 6390 6389 6391 6392 4967 1738 8803 8801 8802 2805 2806 4190 PMC4405237__F1 Diversification of importinA isoforms in cellular trafficking and disease states 5901 5905 5902 10762 PMC4420606__F8 TLR3/TRIF mainly regulates IL-32-mediated pro-inflammatory cytokine and IFNB secretion through activation of RIP-1 and TRAF family proteins 7098 7186 7185 7187 29110 3661 3665 9235 PMC4422156__F1 Schematic of TLR signaling and gene expression following stroke 7097 7098 51284 7099 4615 54472 581 3661 PMC4423147__F8 The Nodal signaling pathway during establishment of the LR asymmetry in amphioxus 4838 2657 9573 8022 94234 27123 27121 22943 PMC4424078__F1 Viral Activation of Cellular Metabolism 3099 8081 2194 PMC4425560__F7 Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway 3717 6774 4318 4313 595 PMC4433221__F5 Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode 3716 3717 6773 8554 10379 581 3659 5696 3430 PMC4433221__F6 Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode 23178 4072 5167 671 91543 7318 51191 3661 4599 6773 83666 4939 10379 103 PMC4439562__F3 Cadherin and integrin signaling pathways 999 1499 2932 324 6934 PMC4442748__F1 M1 and M2 Immune Activation in Parkinson’s Disease: Foe and Ally? 3566 6850 3716 3718 7297 6778 8651 6774 383 942 7124 3553 PMC4446786__F1 Intracellular mechanisms activated by leucine 3479 6510 8140 3717 3667 8660 4553 6009 64798 64223 PMC4447342__F2 Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFKB Signaling in Hepatocellular Carcinoma 8412 8853 54206 7465 5794 27289 9564 2810 57584 5829 85415 81848 5782 388 7791 1435 7408 29775 867 23268 8743 8797 84959 8915 10318 8795 57162 330 7128 6461 840 3656 3459 3566 80149 7321 4792 7538 7132 1999 54894 10379 3716 5971 4790 9043 2626 1026 1021 1326 3397 688 5329 602 64332 64750 5606 672 9111 9322 6498 4092 3725 3091 2353 6303 7057 4088 5328 7040 57154 2113 9260 604 5054 10370 1052 2114 3172 7718 5930 5004 23135 10891 9971 PMC4451040__F2 Back from the dead; the curious tale of the predatory cyanobacterium Vampirovibrio chlorellavorus 324 729 3652 1431 64782 PMC4460069__F1 Comparative Transcriptome Analysis Reveals the Influence of Abscisic Acid on the Metabolism of Pigments, Ascorbic Acid and Folic Acid during Strawberry Fruit Ripening 1725 1719 56961 29925 4351 2821 8836 4598 10654 3652 27159 PMC4465499__F4 Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications 9370 2266 2243 65057 4255 5914 3630 9053 4613 3297 5063 PMC4465887__F1 Advances in recent patent and clinical trial drug development for Alzheimer’s disease 351 43 23385 PMC4466411__F5 Schematic model of the molecular mechanisms associated with PD-induced autophagy in NCI-H460 and A549 cells 2475 10533 64422 PMC4467754__F14 Scheme of possible mechanisms by which AT-101 enhances the anticancer activity of CDDP in NSCLC 7849 1958 6774 4602 3131 5079 PMC4479417__F10 PI3K-C2G is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling 5163 5266 2475 26060 PMC4486472__F2 Neural Tube Defects 635 6472 275 2731 4548 10797 441024 6470 1719 4524 4522 25902 7298 10588 PMC4501477__F4 What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity 472 9656 11073 545 9025 165918 PMC4516462__F2 Transcriptional modifications of DNA repair by UPS in response to cellular stressing conditions 672 7150 580 4350 7515 5426 3978 PMC4523019__F2 Interferon signaling upstream regulator pathway, with subcellular compartmentalization indicated 4313 713 2919 10673 8542 4283 3487 80830 9636 27074 81848 64108 3965 7098 634 684 5359 10410 8739 79094 2633 718 4938 3437 90427 91543 11274 4939 10346 3433 6891 80833 8651 4940 6890 9830 1154 51191 5721 10379 3431 64761 PMC4526690__F3 Comparison of the Transcriptional Profiles of Melanocytes from Dark and Light Skinned Individuals under Basal Conditions and Following Ultraviolet-B Irradiation 4193 6125 6135 PMC4528959__F6 Quantitative phosphoproteomic analysis of IL-33 mediated signaling 3630 2147 2335 89846 2245 998 324 6010 5829 10152 7414 2934 PMC4536022__F2 Integrative Analysis of MicroRNA and mRNA Data Reveals an Orchestrated Function of MicroRNAs in Skeletal Myocyte Differentiation in Response to TNFA or IGF1 894 595 4953 1021 993 4288 2000 7465 1111 1385 983 1026 891 990 5347 890 7884 81620 4605 10155 4173 PMC4538774__F4 Representation of the adherens junction pathway map from KEGG 999 6714 998 4008 1499 387 8826 2241 3480 3643 2260 4088 4089 51701 PMC4539557__F9 This cartoon summarizes our observations and integrates them into the context of previous studies 387923 652 347733 1499 2736 6469 PMC4546491__F2 Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics 2260 4914 2778 1855 6657 57167 PMC4547409__F9 Model illustrating the mechanism underlying inhibition of TGFB1–induced EMT and cell migration by KF 4088 4089 207 PMC4550399__F8 Temporal Gene Expression of the Cyanobacterium Arthrospira in Response to Gamma Rays 51596 252842 729 PMC4557010__F7 Schematic models for JAK/STAT cell signaling pathway and the inhibitory actions for JAK/STAT target anticancer drugs 3976 1950 6714 2475 7018 PMC4557668__F8 JNK-dependent gene regulatory circuitry governs mesenchymal fate 6722 3219 2120 4223 1045 3172 4008 8848 6938 6935 4783 9971 57060 PMC4573074__F1 Regulation of autophagy.Notes: mTOR is one of the most important regulators of autophagy 5728 9776 60673 9140 83734 9474 8408 596 10533 64422 PMC4575837__F2 Dietary restriction, mitochondrial function and aging: from yeast to humans 2309 23410 6648 7019 1977 PMC4582187__F7 Model describing the modulation of MLP quality control at the proteasome by BAG6 and SGTA 8266 6449 7175 7917 PMC4591212__F1 Altered modulation of the IL-8 signaling pathway in AH livers with MDBs 54331 3985 2791 2770 581 PMC4594993__F6 General model for basigin promotes the membrane localization of CD98 and activation of B1-integrin 51361 57403 8766 382 PMC4613136__F1 CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division 920 6741 7520 5893 2547 5888 5591 5889 5892 3014 7518 5883 3981 144715 7516 5810 7517 3364 5884 672 472 545 675 5424 3978 7158 4536 7507 7508 5886 2067 4350 4968 23583 6996 7374 142 10038 3980 993 995 7157 4436 7515 4437 4292 27030 5378 5395 4255 11277 PMC4613136__F2 CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division 920 6741 7520 5893 2547 5888 3014 5890 5889 7518 5883 144715 3981 5892 7516 7517 5810 3364 672 5884 472 545 675 3978 7158 7507 7508 4350 4968 23583 6996 7374 328 142 10038 3980 5886 2067 993 995 7157 4436 4437 4292 27030 5378 5395 4255 11277 PMC4614807__F2 Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus 629 10540 2295 1431 29028 196 3659 79191 3987 706 23764 26230 4628 7341 6662 27339 6659 5793 11186 8241 PMC4615939__F11 Proposed scheme for mechanical stretch-induced VSMC hypertrophy through leptin synthesis, RhoA/ROCK pathway, ROS formation, and GATA-4 nuclear translocation 387 6010 2626 PMC4618041__F7 Model depicting Dcp1-mediated translational repression in endotoxin-tolerant cells 7099 5936 27161 PMC4629535__F5 Canonical pathway and gene network analysis of the 18 identifiers that were expressed in the lungs of PQ-free rats 115330 2863 9934 26996 56834 79188 51002 23432 51246 54680 83667 23087 1801 4088 23608 171392 2865 7157 9175 7158 53836 1978 9344 4214 157310 161742 8036 5922 5116 PMC4631372__F4 Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation 3304 8913 6196 785 5532 3551 5019 51701 8491 5495 79944 65985 6416 5160 2247 4478 2042 25791 5962 56034 8829 5217 1445 7852 2254 2260 3676 3655 PMC4632082__F6 CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity 7189 6714 960 4772 PMC4632950__F2 Molecular complexes involved in the integrin-linked kinase signaling pathway responded to BPS and WEX treatments 5728 8440 3611 7016 2475 3091 650 2318 PMC4632950__F3 Molecular complexes involved in the calcium signaling pathways responded to BPS and WEX treatments 811 9495 10345 444 PMC4636730__F2 Proposed schematic of intracellular immune response to murine norovirus (MNV) infection 9636 6772 3661 3665 PMC4637098__F2 Kelch-like chicken erythroid-derived cap “n” collar homology factor-associated protein 1- (Keap1-) NF-E2-related factor 2- (Nrf2) antioxidant response element (ARE) signaling pathway 8452 9817 9978 1728 4094 3725 PMC4640673__F2 ECM receptors in neuronal structure, synaptic plasticity, and behavior 7436 1600 387 PMC4646736__F2 Proposed pathway of prostaglandin synthesis and interaction with the cyclooxygenase pathways and VEGFA 4513 4512 7422 PMC4648367__F7 Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway targetgenes and promote cell migration 4018 1950 3084 1956 2066 5163 9113 27063 PMC4651715__F4 Three major signaling pathways that regulate cell size in normal cells.A 2475 5728 5163 55615 64798 7249 6009 673 2932 PMC4654299__F2 Regulation of endosomal trafficking 375 382 5873 5874 338382 57403 PMC4657151__F1 Skeletal muscle as an endocrine organ: PGC-1A, myokines and exercise 23411 23410 2475 PMC4657327__F2 FA/BRCA pathway and crosstalk between FA and other DNA repair pathways 116028 80010 545 472 10111 4361 PMC4663607__F1 Effects of vitamin K antagonists and direct oral anticoagulants on coagulation 7018 2147 2717 PMC4664161__F4 TLR4 and TLR3 sensitization 7099 7124 4615 3661 3665 7098 7189 85451 4118 PMC4666504__F7 Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake 1950 3084 1956 2066 PMC4666791__F1 Schematic diagram shows major signaling pathways stimulated by IFNA/B (mediated by the type I IFN receptor) and viral pathogen-associated molecular patterns (PAMPs) and/or ICs-containing nucleic acids (mediated by endosomal TLRs) 3455 3454 7297 6774 6772 4615 4118 7187 51135 7189 8195 10379 2353 3725 3665 3661 3569 PMC4671345__F3 LIF protects cardiac myocytes by both genomic and non-genomic means 3976 2885 387 6774 2932 6648 4513 3977 PMC4682110__F5 Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas 2321 4609 1956 4087 4089 2064 1029 673 5604 4193 595 238 1030 207 7248 2475 9134 3696 3691 1019 11200 6794 1021 4204 29072 128239 85415 998 6597 1387 5879 5881 7204 10765 6624 25794 53353 322 2810 324 6714 PMC4684384__F5 Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages 3553 114609 4615 5163 929 PMC4684823__F9 Schematic summary depicting fluoride-induced oxidative damage and adaptive response 23411 7351 472 PMC4689760__F1 Cholesterol biosynthesis pathway is altered in CEM/R2 cells 3157 3156 3422 3652 2222 6713 4047 1595 1718 7108 6307 50814 51478 10682 6309 1717 6646 8435 3988 19 PMC4694980__F6 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage 9112 4151 79002 307 PMC4698356__F2 Proteins highlighted for their contributions to molecular regulation in diabetes and heart failure 10724 6786 6667 PMC4702938__F3 Example of the allosteric network ‘Calcium signaling pathway’ 10105 5566 5350 6546 90550 7416 3363 2778 107 6786 7134 84876 487 4638 5260 1139 801 818 4843 6261 5333 3708 5335 952 8877 PMC4706435__F6 MiR-124 Promote Neurogenic Transdifferentiation of Adipose Derived Mesenchymal Stromal Cells Partly through RhoA/ROCK1, but Not ROCK2 Signaling Pathway 387 6093 9475 6667 PMC4709785__F1 Metabolic regulation of the pluripotent epigenetic landscape 157739 8473 7351 PMC4714567__F2 Ah Receptor Pathway Intricacies; Signaling Through Diverse Protein Partners and DNA-Motifs 57491 196 8614 581 100188857 5444 405 PMC4714567__F3 Ah Receptor Pathway Intricacies 100188857 1543 196 405 4094 1316 5970 PMC4720263__F4 Signaling crosstalk between the TGF-Beta-activated Smad pathway and the Wnt- and Notch-activated signaling pathways during EMT 4087 4088 2932 4089 1499 51176 23462 999 1003 PMC4728015__F4 Galactose-1 phosphate uridylyltransferase (GalT) gene: a novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts 2592 2584 5728 3479 PMC4731824__F8 Novel NFKB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis 4615 8717 7186 51135 3654 7189 8945 5970 7528 4312 4322 PMC4732619__F7 FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc 4089 4090 4086 2303 PMC4735774__F9 Schematic working model for presumed mechanisms underlying the effects of Mus81 knockdown on hepatocellular carcinoma (HCC) cells in response to chemotherapeutic drugs 619501 80198 995 993 1017 PMC4748726__F4 Network of osteogenic specific proteins regulated by BMP2 signaling 650 249 6678 3381 632 860 6696 1277 1278 PMC4755791__F3 Toward an Orofacial Gene Regulatory Network 3664 7021 54101 79977 4322 4851 126695 7043 4149 4087 4088 57822 4089 7022 5017 8626 PMC4757551__F5 Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01 717 5106 440 PMC4762627__F4 NFE2L2-Regulated Antioxidant Response in Activated Microglia 8878 4199 4200 2052 5052 2932 10963 2729 2730 847 2495 9097 10574 8192 873 7295 7415 5479 10961 2936 PMC4762928__F1 Glucose and glutamine metabolism in cancer cells 2539 5163 3939 2744 PMC4767488__F1 Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis 6422 27122 324 2932 1499 PMC4772380__F10 HCV induces transforming growth factor B1 through activation of endoplasmic reticulum stress and the unfolded protein response 468 22926 467 PMC4773033__F2 Comprehensive picture showing gene expression changes and crosstalk of pathways associated with Igf1 and Pacap rescue of apoptotic CGNs 3479 81029 6469 5155 26291 54361 3688 4803 2260 5727 2534 51684 3667 54407 847 2885 779 6376 776 3702 3265 3306 7852 5906 3303 6472 2833 29956 3304 10197 1847 3418 2940 189 2946 11151 5723 6722 51268 134 116444 8811 PMC4775036__F5 Main canonical pathways induced by cigarette smoke extract 2322 1499 3091 79923 1270 4803 54210 6395 PMC4785873__F3 Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons 221092 26205 11179 10857 55290 200185 5201 26155 1478 6431 1911 PMC4795779__F1 Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration 22926 83939 7494 468 PMC4815038__F8 ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies 4553 1998 468 4170 54541 596 PMC4818113__F6 Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways 4810 6007 2242 PMC4820821__F1 Hh signaling pathway 374654 51684 6608 5727 91653 2619 132884 2121 PMC4823852__F7 MicroRNAs downregulated in OSCC target multiple genes in the PI3K/AKT pathway 2475 1977 6009 7249 6194 3265 66037 5879 613 6850 930 572 5266 5728 1147 4193 PMC4823852__F8 MicroRNAs upregulated in OSCC repress multiple genes in the p53 signaling pathway 1017 472 545 355 1869 4609 637 581 842 836 94005 4193 64065 6237 7249 5728 64326 6477 PMC4825819__F5 Coordinating muscle-specific gene expression with cell cycle exit 1017 1021 1019 9615 PMC4831676__F7 Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells 664 665 2475 8408 26750 8986 8637 6194 1977 468 83939 PMC4831703__F1 The isoprenoid biosynthetic pathway (IBP, ) provides critical substrates for posttranslational modification of proteins that modulate cell signaling and regulatory processes 3652 2224 5906 PMC4831796__F7 Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF 411 10457 4286 PMC4833509__F7 Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa 6120 10628 406959 406958 407053 355 PMC4835216__F6 Prostaglandin-mediated inhibition of PTH-stimulated Beta-catenin signaling in osteoblasts by bone marrow macrophages 1499 4513 5741 PMC4848607__F1 KEGG pathway analysis for the Toll like receptor (TLR) signaling pathway differentially expressed genes (DEGs) expressed in response to SAV-3 infection in TO-cells 7124 54472 114609 10333 7097 8772 3569 3929 929 23118 4352 4351 7189 958 923 51135 3665 1513 130749 54106 7187 7098 PMC4850467__F1 Different compounds in cigarette smoke regulate EMT 5053 6714 196 999 PMC4851164__F3 Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation 6469 3082 3479 1950 2268 3480 1956 6608 960 6714 2521 2885 2932 9557 51684 3611 998 8313 5058 23462 1958 6591 6615 7291 2303 6935 999 9839 PMC4851164__F7 Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation 999 6935 6615 3611 2932 6469 6608 51684 2521 PMC4851692__F4 Effects of C10 on gene expression 5166 5165 37 5106 4717 PMC4858865__F1 Overexpressed metabolic pathways in the infection 64853 383 100187761 PMC4864395__F5 Menadione Suppresses Benzo(A)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism 1543 196 405 PMC4865030__F1 Interplay between Fanconi anemia and homologous recombination pathways in genome integrity 5888 9156 641 672 1763 7486 545 91442 11073 79728 83990 5889 675 8105 55215 199990 29089 22909 84464 348654 PMC4873349__F2 IPA canonical pathway Cell Cycle: G1/S Checkpoint Regulation with up-regulated genes in the IR-induced common translatome highlighted in pink 55003 472 545 4193 648 4089 4088 4149 1017 3084 25942 6839 PMC4878851__F5 Lifecycle of cardiac Nav1.5 and potential phenotypic modifiers 859 4734 2308 6331 6910 PMC4885545__F5 Possible molecular targets whereby luteolin (Lut) inhibits the invasion of cancer cells 7038 7422 998 4193 355 999 3082 2475 PMC4888836__F1 Model for the noncanonical HDR pathways at two-ended DSBs 4361 9156 2067 5893 5888 51750 5426 PMC4890891__F3 Regulatory network of Katanin protein 8452 4738 6500 3950 8445 PMC4894314__F1 Effect of HDACI on cell survival signaling pathway in hemorrhagic shock 2932 5728 1499 PMC4897699__F7 Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury 4282 960 972 PMC4905194__F2 Mechanisms of gap filling 5111 56852 5426 5888 118027463 80010 80198 PMC4909382__F7 Schematic depiction of the antiapoptotic conditions including the PRL signaling pathway in young RPE versus the proapoptotic conditions in aging RPE 6120 22933 5618 5617 PMC4910876__F2 Mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging 3479 3643 64798 7249 3717 4485 3667 8660 5163 130497 PMC4918391__F2 HVJ-E-mediated cancer cell death.Notes: (A) HVJ-E-mediated apoptosis signaling in cancer cells with CASP8 3665 3661 57506 836 842 841 PMC4918620__F4 MAPK signaling pathway (orange nodes are associated with upregulated or only whole dataset genes and green nodes have no significance) 1610 3925 4803 6955 4351 6722 2316 1386 7186 355 4149 4208 929 100187907 PMC4923163__F3 BDNF and TrkB signaling pathway 627 2885 2549 5163 5728 PMC4926194__F2 Known host targets of phleboviral NSs proteins in retinoic acid-inducible gene 1 (RIG-I) signaling and type I IFN induction 7706 57506 29110 3661 PMC4931191__F2 Relationships between longevity genes affected by the diabetic milieu 23411 9575 2475 6648 PMC4931961__F3 TNFA Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB 7124 958 8567 55840 8717 8772 11171 29110 10010 637 2353 PMC4939482__F3 Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure 367 59272 4313 4318 545 PMC4945843__F1 Major cholesterol metabolism pathways in the liver 3949 9619 19 2194 1581 3156 PMC4951507__F4 ICL repair 29128 2177 55215 84464 57697 675 5888 672 545 80198 PMC4969639__F7 Proposed model for IFNGamma-induced apoptosis of HNSCC cells 3458 3717 3716 837 1386 842 836 PMC4970276__F8 Model deciphers molecular mechanisms by which PRMT5/p44 controls cell growth 10419 2065 2064 11010 7832 PMC4975146__F3 Signal transducer and activator of transcription tyrosine kinase domain c-Kit in cancer cell.Notes: The Ras-Erk pathway, PI3K/AKT pathway, and Src-signaling pathway have been demonstrated in this schematic picture 5728 6714 5163 2885 595 596 8651 8835 9021 PMC4980741__F2 Signaling pathways regulated by SHP-2 in the gastrointestinal tract 6774 1950 3082 2549 3667 1499 PMC4984662__F8 Bunyavirus-induced Wnt/Beta-catenin signaling 4040 4041 2932 1499 324 595 607 PMC4987369__F1 Schematic representation of a mechanism of action for cannabinoid based multi-target drugs 2166 4513 7442 PMC5000709__F2 Kallistatin inhibits angiogenesis and inflammation through blocking VEGF signaling and NADPH oxidase activity 5163 5164 6714 5879 7422 PMC5000709__F3 Kallistatin inhibits Wnt canonical pathway induced angiogenesis and inflammation 5879 998 1499 2932 51199 4040 4041 PMC5004130__F6 Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride 8213 3717 5970 3565 6346 1356 1401 PMC5007815__F7 MAPK/MSK1/Histone H3 pathway on target gene transcription 2885 1958 2002 3397 PMC5009010__F9 Schematic signal transduction network representing the effect of chronic alcohol on protein balance in eWAT 7249 7248 6009 1975 8408 29904 27250 1977 1938 9474 9140 PMC5009362__F9 Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination 4615 7189 10454 3654 51135 23118 257397 PMC5011655__F6 Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine 3356 147 3361 4843 111 5350 7225 572 5138 2099 134 140 5320 5319 185 4318 1909 PMC5039030__F8 Model - DPP9 is a negative regulator for Syk signalling, targeting active Syk for degradation by the N-end rule pathway 613 6850 91039 867 2316 PMC5042386__F2 Regulation of the Hippo signaling pathway in mammalian cells 10207 8777 324 4771 1499 6010 5784 4485 9113 26524 154796 7003 8463 7004 7005 PMC5050441__F33 Multitargeted modulation of estrogen carcinogenesis by botanicals 196 9817 405 4118 PMC5054714__F2 DEGs in cell cycle pathway Up-regulated and down-regulated DEGs are highlighted in red and green, respectively 7040 5591 545 10744 4089 5925 11200 4085 7532 5111 9134 896 890 9133 85417 902 1017 8556 7027 5933 140739 PMC5059634__F3 Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes 1431 727 2548 PMC5067323__F1 Metabolic pathways associated with DA 5053 1644 7054 1312 1565 4128 4129 1621 217 224 PMC5072284__F6 Activation of phenylpropanoid-biosynthesis pathway in response to cold storage 790 6497 2271 100653366 1431 1312 PMC5074356__F1 Signal transduction mediated by the extracellular calcium-sensing receptor (CaR) 387 759 847 PMC5094751__F12 Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells 19 8877 50507 152007 2919 3248 10631 1839 5328 1947 55070 1191 1501 9863 6288 1809 7078 84650 3383 57674 4741 1909 9956 80095 3691 10024 4908 2247 2181 100132948 1356 25907 4318 5580 5764 23224 288 9244 138065 8728 7168 4316 2151 384 4853 4255 7046 497190 1869 56999 7404 5909 54843 3115 114784 9721 7424 1080 3156 2069 55845 440435 4744 147166 596 9260 6422 PMC5094909__F1 Energy Metabolism and Inflammation in Brain Aging and Alzheimer’s Disease 3630 3479 2885 PMC5094987__F7 EZH2-mediated repression of GSK-3B and TP53 promotes Wnt/Beta-catenin signaling-dependent cell expansion in cervical carcinoma 7471 324 2932 2146 7157 23512 1499 8726 PMC5097364__F2 Signaling pathways involved in cell-cell adhesion mediated by E-cadherin in physiological and pathological conditions 107966124 23440 412 1356 999 324 1499 3801 6010 100187761 PMC5097896__F6 The Activin/TGFB mediated Smad2/3 signaling pathway 4838 4092 4089 PMC5099115__F3 IGF-1R Signaling 3479 3480 5728 PMC5102796__F8 Model showing the relationship between HPV-induced replication stress, activation of the ATR/Chk1/E2F1 signaling pathway, RRM2 accumulation and productive viral replication 545 1869 6241 PMC5105060__F9 Analysis of Zinc-Exporters Expression in Prostate Cancer 1437 6351 9560 7780 5817 7781 9077 250 3643 7779 64924 169026 148867 81609 55532 1994 55676 79608 23559 8775 10331 7782 340204 58517 10463 PMC5108756__F2 Inhibition of the complement system by pathogenic fungi 718 109245082 2820 5340 727 PMC5129466__F1 Insulin receptor (IR) and insulin‐like growth factor 1 receptor (IGF1R) signalling pathway 3479 5163 2885 2932 PMC5131917__F8 PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress 163859 56852 5111 PMC5133730__F7 Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway 359 7474 551 PMC5137308__F7 Molecular mechanism for neurogenesis activated by 5-HT4 receptors by MOS 2668 4342 2674 5979 2885 2549 10253 26153 5728 6010 998 PMC5139832__F3 Differentially expressed genes between young and aged tibiae are significantly enriched for ECM-receptor interactions, TCA cycle and cell cycle pathway components 1737 1431 48 4191 3421 8802 6389 8803 4967 993 994 983 1021 1019 1017 999 4661 10926 990 8317 1874 1869 23594 5001 PMC5140697__F1 Targeting cancer metabolism: dietary and pharmacological interventions 3845 2475 3091 5723 26227 4609 3939 47 2194 2744 6510 PMC5144105__F2 Signal transduction pathways in cranial development 2248 2249 7473 4040 4041 2260 2263 2261 89780 10023 4086 4090 1499 4089 2077 7291 6938 860 4488 PMC5177915__F8 Citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway 7099 1152 7018 467 PMC5207462__F2 Insulin signaling pathway 2885 5266 5163 PMC5215839__F2 Posttranscriptional mechanisms of regulation of the miRNA biogenesis pathway 3178 54487 29102 23318 PMC5216743__F6 Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells 7099 695 7249 7248 1977 PMC5226065__F4 Mechanisms underlying SQ induced self-renewal 2475 3611 6010 595 PMC5228376__F3 Cytokine-cytokine receptor interaction of secreted cytokines 6351 6348 6357 6354 7423 2321 1230 7422 6358 3791 6360 2324 6368 3082 6359 1232 1956 1950 6355 1436 1435 6356 6369 4254 3815 10344 2323 2322 PMC5234130__F4 Terpene biosynthetic pathway, and heatmaps displaying the expression (log2 FPKM) of enzymes involved in the different reaction steps 4200 340451 4598 7216 3652 4597 PMC5240474__F2 Inhibition of the NOTCH pathway by NUMB 182 3714 102 6868 2060 4855 4853 4851 4854 1024 23462 3516 8650 PMC5243144__F4 Schematic summary of metabolic pathways disturbance caused by suppression of pyruvate carboxylase in MDA-MB-231-derived cell lines 5091 4199 355 3418 3417 2744 PMC5245686__F2 Metabolomics and Metabolic Diseases: Where do we stand? 5091 23152 3417 PMC5253647__F6 SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers 6597 22974 6790 PMC5257030__F8 Scheme of the interaction between the intrinsic apoptosis, autophagy and stress response pathways governing the HepG2 response to CdS QDs 64422 9776 22863 10533 596 581 317 4189 PMC5270332__F8 Schematic diagram depicting the KRT19-mediated regulation of NUMB expression, NOTCH signaling pathway and cancer/cancer stem-like cells (CSLC) properties in KRT19-overexpressing breast cancer cells 5879 3880 1499 4851 9794 3280 8650 595 3265 PMC5293580__F5 Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways 6009 8491 2475 PMC5298863__F4 Intracellular signalling pathways that are activated by insulin and amino acids after feeding and that lead to the activation of translation initiation in the immature skeletal muscle 5163 5728 7248 7249 253260 6009 2475 5337 1977 6194 PMC5302293__F1 Cell-cycle and DNA repair 4654 1019 1021 7157 1026 5925 1869 1017 9134 1786 2309 4292 1647 5111 9133 995 7518 7520 2810 3725 5728 664 581 842 317 836 7124 6772 332 PMC5303000__F2 Role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia 3099 2744 65009 10397 1499 4609 57447 7428 57446 PMC5320444__F5 Comparative physiological and transcriptomic analyses provide integrated insight into osmotic, cold, and salt stress tolerance mechanisms in banana 7018 847 5163 4602 PMC5321202__F1 CORM-2 influences IBA-1- and GFAP-positive cells and many nociceptive factors and signaling pathways as measured on day 7 after CCI 114548 10068 7076 3586 PMC5323150__F12 SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride 23411 4485 1647 PMC5323160__F10 Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis 7422 2534 6461 998 6714 PMC5332476__F2 Inhibitors of Rho GTPase and Rho kinase lower IOP by increasing aqueous humor outflow through the conventional pathway and exhibit neuroprotective effects by stimulating axonal outgrowth and retinal ganglion cell survival 387 718 6010 PMC5337695__F2 EGR1 regulations and functions in the central nervous system in the context of synaptic plasticity 6722 2002 4664 1958 9342 9892 10228 2571 1139 2902 23237 PMC5340233__F4 SIN3A and SIN3B differentially regulate breast cancer metastasis 8717 894 11166 PMC5343412__F7 Phylogenetic relationships of algae thiorredoxin-like ferredoxin domains 6723 192 6098 PMC5344275__F4 Biological responses leading to angiogenesis driven by the HGF–Met pathway 3082 1003 6774 PMC5347907__F3 Functional long noncoding RNAs (lncRNAs) in inflammatory pathways 105416157 4513 5228 7097 7098 7099 102659353 3182 3191 6421 PMC5352388__F7 N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways 1000 595 4316 4318 4313 4323 999 PMC5360051__F5 Proposed deregulation of type I IFN signalling pathway by AFB1 3716 7297 6773 PMC5362412__F9 Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression 2821 50 2597 3418 4967 5315 PMC5363987__F8 CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy 5617 5548 50624 2069 2066 5618 PMC5364965__F2 Notch gene signaling pathway interactions 1856 8650 3955 3280 4851 84667 4853 4855 182 3714 23385 PMC5366136__F5 Relationship between the nine DEGs in network 1 in the Jerseys 23395 51218 84817 155038 1652 2109 55303 83696 122553 6778 284114 2790 PMC5369969__F14 HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo 6648 5894 7249 572 2475 4170 8408 581 637 472 9776 10013 3066 10014 83933 79885 PMC5372728__F1 Lipolytic and lipogenic pathways in white adipose tissue 4023 948 4099 2194 95 PMC5381705__F4 Target genes of Tongcheng/Landrace specific DEmiRNAs' KEGG pathways enrichment analysis (a) Landrace specific DEmiRNAs target genes enriched in cell cycle pathway 9126 5885 9184 5111 1019 1022 1017 4661 999 10926 355 8772 843 836 8717 637 842 4803 572 PMC5381904__F2 Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability 5166 5563 6790 1021 1019 324 9212 PMC5398616__F3 Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle 8295 10009 7532 10777 PMC5404743__F1 New Milestones Ahead in Complement-Targeted Therapy 1431 2271 341567 718 1380 1311 PMC5404978__F10 Proposed model for FoxO1 and AMPK regulation of EtOH-induced autophagy 8408 5289 22863 8678 55626 10533 8878 PMC5411695__F3 Hedgehog (Hh) signal transduction in the primary cilium 51684 2737 2736 6608 2121 5727 23432 7289 6469 8454 PMC5412347__F7 The VEGF/VEGFR/HIF-1A signaling pathway and the effects of melatonin treatment leading to the activation or repression of downstream molecules in OC cell 4199 9575 7040 4088 4087 PMC5412423__F6 Ceramide metabolism in desipramine-pretreated mice undergoing septic cardiomyopathy 6609 6610 55512 6611 5515 8560 29956 79603 91012 427 56624 81537 8877 56848 PMC5415769__F2 Canonical pathways form groups for each individual protein 5052 3105 3920 203068 3916 9114 523 10312 528 998 10097 1432 4637 5062 2207 10094 7094 122618 10109 5788 23020 3183 5336 55660 9129 10594 51100 408 4643 348 10092 6010 4627 6648 847 7384 7385 1347 7416 1345 4701 3028 6389 4709 1340 4967 4190 2730 873 2512 9446 10574 5479 2495 3032 1892 3030 3712 1629 5019 3155 4860 3930 7040 3643 567 3635 253260 8651 1778 6774 5465 2475 3458 351 10327 8569 2908 7157 5468 4609 2099 7942 PMC5420131__F3 Immune exclusion through Wnt/beta-catenin pathway: Activation of Wnt/beta-catenin pathway in tumor leads to noninflammatory milieu through multiple mechanisms 8205 467 3553 6351 1499 50943 PMC5421298__F6 Gene expression changes in the TGFB signaling pathway 9241 650 659 8646 9372 657 25805 4086 57154 4092 7124 7046 9475 387 4087 4089 5516 6198 6500 5933 4609 1874 1030 8454 7027 1387 6667 91 90 10468 3626 7042 7057 1634 PMC5430631__F6 Distribution of Turkish galls target proteins on the compressed UC pathway 7097 50943 324 PMC5437015__F8 Canonical Pathway of ‘Molecular Mechanisms of Cancer’ (IPA, p-value 0.0199) 867 6247 4763 2534 6010 4193 2308 572 596 28996 2177 472 637 4609 4149 672 581 595 54205 3091 5933 51176 51684 27148 6714 8772 1616 23385 914 PMC5453942__F3 Map of DEGs in Oncopig leiomyosarcomas and their functions within the TP53 signaling pathway 595 4193 545 1029 1026 894 7157 891 2810 4616 85417 10912 27244 143686 50484 355 51512 5366 581 64065 3486 637 54205 7057 5054 3732 317 842 836 PMC5457443__F6 Functional analysis of IRF5 pathway 29933 10482 6870 7113 5213 54329 3781 10075 2873 79102 8453 5605 79132 386746 55030 1259 8767 10893 80352 29089 79872 5128 140456 4320 339221 3663 2895 PMC5463201__F2 Endogenous sources and consequences of ROS overproduction 27035 50508 79400 50507 53905 50506 PMC5466605__F9 Illustration of a proposed signaling pathway of innate and adaptive immune activation in the Nx model (A) 834 114548 3554 3553 23118 10454 841 7097 3725 64127 7124 3665 3654 4615 7189 7100 3458 51284 3663 54106 3627 7099 929 3929 941 3661 942 958 6352 3606 PMC5473921__F2 Network of organismal abnormalities and cancer 140576 59342 4060 214 9168 9404 10452 30844 2745 800 6185 10397 51144 6286 6271 PMC5474518__F75 Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3B Signaling Pathway 9023 2932 572 PMC5478092__F5 Metallothionein roles in aging and reactive oxygen species 5163 207 208 11016 PMC5479927__F1 CoQ biosynthesis and effect of 4-HB analogs 3652 57107 7054 218 27235 10229 51805 51004 84274 PMC5482964__F3 Signal transduction by BG 7097 7099 51135 7189 325 29110 3661 7187 114609 PMC5483452__F8 Schematic illustrating the role of Nupr1 in METH-induced apoptosis and autophagy in neuronal cells 26471 57761 2475 PMC5483589__F5 Ror2-expression-responsive module 4920 2316 5590 1856 5602 10411 11065 1445 5603 7169 7867 72 8915 1051 109 5530 5332 9261 5566 6196 359 1385 90390 948 8864 4862 2908 2155 123 5045 4802 183 19 7005 4311 1522 1509 10159 PMC5485424__F9 Schematic model of BRAFV600E signaling-induced epigenetic silencing by H3K27me3 in tumorigenesis 29102 4149 2638 2146 2145 6418 23512 8726 121536 3720 PMC5495797__F7 Differences and commonalities in TLR4- and FcERI-activated production of proinflammatory cytokines 7099 8915 10892 7189 23118 257397 7124 4615 4118 27040 PMC5501768__F1 Scheme depicting mechanisms of resistance observed to BRAF and MEK1/2 inhibitors in vitro and in vivo 5159 1956 558 2064 4893 5728 673 PMC5501892__F2 Metabolic profiling of intracellular glycometabolism 3667 5163 3098 25796 2539 5226 7249 22934 2821 6888 6009 4609 7086 286016 2597 5230 2023 5160 1431 4190 48 2271 3417 4967 6389 1743 8801 PMC5501892__F4 mRNA expression of enzymes and factors involved in glycometabolism 5562 5563 5565 6513 5564 3667 3098 5226 5571 51422 53632 25796 5163 2539 2821 7248 7249 5213 6009 22934 6888 226 4609 286016 7086 7167 6198 2597 3091 5230 2023 5315 3939 5160 1431 4190 48 2271 3417 1743 4967 6389 8801 PMC5506009__F1 Functions of experimentally verified target genes of miR-17-92 were analyzed by GeneMANIA using genetic interactions, pathway, and physical interaction parameters 1831 7786 79791 6346 5934 4609 132864 5800 894 57169 7107 8651 3815 659 10365 1026 3696 4893 7422 595 3791 1871 2152 841 8850 6774 596 8742 7057 3298 4863 351 3660 7048 10018 10425 7525 1870 472 999 5925 663 3716 51277 5728 4209 10114 2263 5311 2100 6401 29116 51341 PMC5519084__F5 Activation of aromatase promoter I.4 and promoters I.3/II in breast adipose fibroblasts and promoter I.7 in breast endothelial cells 6774 6667 2624 1385 5266 200186 1386 7536 PMC5524345__F9 Dkk3 gene encodes a vital intracellular regulator of cell proliferation 999 1499 324 4040 4041 PMC5535855__F3 Schematic diagram showing the pathological cardiac functions of ANKRD1 in relation to hypertrophy, fibrosis and apoptosis 5340 27063 2626 7077 4691 642658 4016 3489 221458 4855 4088 581 PMC5535903__F2 Nucleolar response to DNA damage 7518 5888 672 472 4869 4691 581 2091 641 7486 PMC5536000__F5 Schematic of the miR-206 regulatory mechanism during adipogenesis 1499 2167 4023 1977 PMC5541032__F3 Antibody-dependent enhancement (ADE) of Zika virus (ZIKV) and strategies to limit it 6772 3569 3586 PMC5543436__F1 a The subcellular localization of the three isocitrate dehydrogenase isoforms and their roles in normal cellular metabolism 3418 3417 355 PMC5545931__F6 PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer 3480 10399 2885 5163 PMC5549971__F4 Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses 367 1950 54115 3918 3248 2690 847 3845 389 387 1462 7498 1471 3725 4800 4937 7227 467 7421 7080 5327 2475 5970 2353 7175 PMC5556685__F2 Working model illustrating the potential impact of milk exosome-derived miRNAs on the expression of p53 3479 3480 367 5728 2308 581 7249 PMC5557697__F3 Model depicting the Cdc42-mediated regulation of EGF receptor interactions with c-Cbl 1950 1956 867 998 PMC5557756__F7 Schematic of a mechanosensitive pathway whereby low magnitude SS acts through the ER stress response pathways XBP1 and eIF2A to promote IRF-1-mediated VCAM-1 expression and VLA-4-dependent monocyte adhesion 7412 7494 83939 22926 3659 3383 PMC5569050__F5 Mechanism of skin dopaminergic sensory modulation 7442 1621 1312 63895 PMC5572632__F2 Salvianolic acid B protects against diabetic atherosclerosis via the Nrf2 signalling pathway 9817 1728 847 4094 PMC5582996__F1 Configuring a robust nervous system with Fat cadherins 351 8642 2196 120114 79633 9456 1822 7408 PMC5584126__F8 CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors 1604 2821 3932 6657 79923 4292 672 4920 PMC5593678__F2 Autophagy in hepatocellular carcinoma: friend or foe 1956 5728 202309 6009 83939 468 PMC5615340__F5 Crosslinks between integrin and wnt signalling 3611 2932 1499 999 PMC5636987__F6 Proposed working model: POPX2 regulates the TAK1-IKK-NFKB pathway during DNA-damage-induced apoptosis 7189 472 23118 257397 10454 PMC5639307__F7 Summary of the study results with pathway 6469 5879 6608 2736 51684 2735 PMC5641113__F9 Genome-wide functional analysis on the molecular mechanism of specifically biosynthesized fluorescence Eu complex 1977 2475 6009 1975 5586 3815 285 5879 613 6850 930 81553 3561 5934 7531 5747 5728 572 1386 150365 5266 6256 4193 PMC5642988__F1 Hippo pathway in intestinal regeneration and disease 5784 10413 6010 154796 4485 60485 9113 26524 PMC5647101__F2 The co-expressing network of differentially expressed lncRNAs and mRNAs 54829 23397 144455 8833 55324 55689 5053 349565 55486 55892 7037 6683 54965 7404 85480 5144 4651 26137 1674 84648 646 145270 2196 6273 374897 682 3860 10804 388533 4163 3861 1475 9407 400578 3237 2709 85439 3664 PMC5648159__F6 Short-chain fatty acid receptors inhibit invasive phenotypes in breast cancer cells 2867 2865 9113 10413 999 PMC5655592__F6 Genes affected concordantly within the ileum and meta-analysis data sets formed biofunctional clusters of overlapping pathways 1493 940 1234 PMC5662193__F6 Cytotoxic Vibrio T3SS1 Rewires Host Gene Expression to Subvert Cell Death Signaling and Activate Cell Survival Networks 652 9510 3576 2920 2919 5328 6347 3569 8817 6781 1437 1440 8744 3976 50615 347902 7056 3383 4792 10749 26353 599 6446 3638 55312 717 6648 331 2152 8651 5743 8870 639 7538 5366 1827 1052 22807 1051 3398 3164 1316 467 1831 4929 1843 2353 3727 8013 11221 8553 9314 10365 3725 4091 1027 163227 688 10769 7291 5978 4783 1958 PMC5664393__F7 B-cell activating factor (BAFF)-BCR crosstalk in chronic lymphocytic leukemia (CLL) cells 7186 4067 6850 695 5971 6774 613 PMC5668879__F10 Proposed effect of polyP and retinol on the expression of the fatty acid binding protein 4 (FABP4) and leptin/leptin receptor 54567 7422 64220 127 5894 2475 2167 2308 2113 PMC5671492__F7 Biphasic concentration-dependent regulation of Cav-1 gene expression and GSK-3B activity by fluoxetine in astrocytes 1950 1956 6714 2932 PMC5683310__F2 Molecular pathways regulated by ZNFs in physiological conditions 1499 9314 1487 1488 23186 79755 5493 5317 5932 9454 23028 4656 4608 4635 688 9172 1893 3065 11005 1041 2312 5468 PMC5696170__F7 Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells 972 4282 960 5970 PMC5701083__F2 Signaling pathways involving PFKFB3 1950 2147 5209 6722 324 999 PMC5701083__F3 Roles of PFKFB3 in different cancer cells 940 5209 6667 PMC5702304__F3 Overview of human TLRs activated by exogenous and endogenous ligands, such as fragmented DNA from necrotic cells; adapted by permission from Macmillan Publishers Ltd, Nature Reviews Gastroenterology and Hepatology, 2006, vol 7098 7099 114609 4615 7187 51135 23118 257397 3661 3665 PMC5705900__F8 Possible mechanisms through which crocetin and AS101 reverse the early adaptive response of the ovary to CPM 6648 23410 1368 PMC5711834__F16 Schematic model of the Keap1/Nrf2 signaling pathway 9817 4094 847 PMC5713354__F2 Current possible strategies to bypass AVPR2 mutations responsible for X-linked NDI 387 554 551 1956 6343 359 PMC5716453__F6 Molecular mechanisms underlying the neuroprotective effect of IGFBP-6 via IGF-1R-dependent signaling 3489 3481 3479 3480 581 PMC5727330__F1 Downstream effectors of Ras pathway including Ral pathway and their biological roles 9610 5900 998 6010 PMC5727330__F2 RalA/B effectors 5879 998 10928 387 5898 5163 5337 595 PMC5729506__F8 Schematic EGFR signaling pathway 1950 2475 1499 PMC5731853__F7 Let-7g suppresses both canonical and non-canonical NFKB pathways in macrophages leading to anti-atherosclerosis 5971 5970 581 3603 6721 19 PMC5732365__F1 Rho GTPases and AD pathology 5879 387 351 6010 PMC5732388__F3 Key downstream genes were identified in the PLK1 signaling pathway 701 4751 10112 5718 4609 64151 28984 11130 PMC5737867__F5 The involvement of the brain-derived neurotrophic factor (BDNF)-glycogen synthase kinase-3B (GSK-3B)-Beta-catenin pathway in the antidepressant-like effects of Morinda officinalis oligosaccharides (MOs) and resilience to stress 4342 627 2932 1499 PMC5739026__F1 Three main classes of regulatory small RNAs 29102 23405 27161 26523 192669 22937 PMC5745708__F9 PMSC differentiation into skeletal muscle using the insulin-like growth factor system 3489 3481 3479 3667 2475 6657 79923 4656 PMC5748986__F2 Protein sequestration at the nuclear periphery 4087 8841 3065 64400 5111 51548 7528 7486 142 5931 5928 11201 PMC5751354__F2 Molecular changes driving the Warburg effect 5728 2475 3091 2023 5132 PMC5751354__F4a Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance 3939 3418 3417 PMC5753034__F6 DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages 25939 983 4171 PMC5755497__F7a Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation 4838 2249 1855 5163 324 7547 79923 6657 8433 57167 PMC5755497__F10a Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation 4194 472 545 11200 9320 4193 1111 8493 6790 79866 2033 5347 56475 7465 PMC5768893__F6 Schematic Representation of FGF4 Signaling Regulated by O-GlcNAc in ESCsPhosphorylated PKCζ, the active form, activates the MEK-ERK1/2 pathway by FGF4 stimulation 8473 2249 79923 2627 PMC5770784__F1 Schematic drawing of the interactions between AB(1‐42) and IGF‐I receptor signaling 3480 2932 627 PMC5777349__F9 SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis 310 6774 6347 8862 3572 PMC5777791__F9 Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer 581 595 6502 PMC5779028__F8 Local TRPV4 channel‐dependent Ca2+signaling regulates endothelium‐dependent vasodilation in resistance‐sized PAs 7851 59341 3550 2638 PMC5788303__F1 Activation of the lipid signaling pathway by GluN1/GluN2A receptor and the creation of transporter mediated drug resistance 619501 4513 9429 PMC5799368__F7 Model for the regulation of BMI1 on androgen receptor independently of PRC1 9055 8726 4193 367 7113 PMC5801404__F2 Mechanistic map of the signaling pathways involved in local translation mediated by class I mGluRs in neurons 5091 23426 139189 23237 4131 2932 2475 1977 29904 PMC5809401__F9 Schematic representation demonstrating the mechanism by which silibinin inhibits NSCLC metastasis via the EGFR/LOX signaling pathway 1950 1956 4015 PMC5817350__F2 Releases and signalling of IL-33 90865 59307 4615 3654 51135 7189 PMC5832853__F8 Mechanism by which ECH enhances the sperm counts 367 2798 5624 PMC5837819__F2 CK1 in Developmental signaling: Hedgehog and Wnt 6608 4040 4041 324 PMC5842119__F1 NAD+ intermediates: The biology and therapeutic potential of NMN and NR 10135 23057 93100 952 64802 22933 23411 349565 142 10038 51547 51548 23410 23409 23408 PMC5846498__F2 Novel bacterial ADP-ribosylating toxins: structure and function 1950 1839 4035 PMC5846637__F7 PD0332991-regulated gastric cancer cell signaling networks 1356 5728 4803 780 595 637 581 331 324 PMC5851616__F9 Tilianin improved myocardial apoptosis 581 27429 331 PMC5852601__F1 Relationship between epithelial-to-mesenchymal transition (EMT) and the Wnt pathway in glioblastoma-derived stem cells (GSCs) 7474 7855 2932 324 6935 4040 4041 4919 847 PMC5852779__F2 TLR2, TLR4, and TLR5 signaling pathways 7097 7099 10333 7098 7100 4615 3654 3656 51135 7189 7187 29110 3661 23118 PMC5853106__F2 Non-Canonical Wnt-signaling: Non-canonical Wnt/PCP (planar cell polarity) pathway 759 6259 847 387 998 51701 PMC5858516__F9 HyFS and the Hsp90/Akt/mTOR axis in lung cancer cells 2475 8408 60673 9776 PMC5863502__F1 Antiviral Innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells 3439 7098 7189 6773 3661 57506 3627 51660 PMC5866057__F1 MTOR signaling pathway with potential contributions from GABA and Glu receptors 18 551 7422 6908 3486 3479 6622 5728 51719 1431 596 7249 9776 5625 6009 2695 PMC5877752__F1 Homocysteine (Hcy) metabolic pathway 5212 4397 4524 PMC5883056__F8 Compound 1G with the intermediate signaling pathway 1956 1950 6667 2099 6502 1312 6500 PMC5890100__F2 Whenever there is any inflammatory stimulus to the cell, there is activation of several molecular cascades such as NFKB, Nrf2, MAPKinase, JAK/STAT, p53, PI3K/mTOR, CREB, and Wnt/Beta catenin 4615 1499 54472 2475 9817 5971 3550 572 581 3726 PMC5890734__F1 Overview of Ethylene Biosynthesis and Signaling Pathways in Arabidopsis and Environmental Factors That Modulate Ethylene Signaling 404685 64641 1879 PMC5900707__F1 Schematic diagram of RIPK1 domains, interacting proteins, post-translational modifications, and the catalytic enzymes that read or write these modifications 11035 8737 23118 9825 1540 8717 7186 57162 10133 PMC5905998__F1 Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways 5471 5163 2475 10606 435 471 PMC5908099__F4 Signalling interaction of the death receptor pathway and mitochondrial pathway 5836 2752 1362 PMC5912715__F3 Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation 5743 2996 5740 54115 4049 4056 94005 5742 23118 PMC5915111__F10 Signaling pathways in the glaucomatous trabecular meshwork 25805 7099 4089 4086 PMC5928262__F1 Ang/Tie pathway regulation of vascular stability 1003 6714 7075 5879 387 2308 51665 7220 6010 PMC5929409__F4a In vitro study on role of σB protein in avian reovirus pathogenesis 6280 89780 2247 8817 650 6279 7099 302 4921 5027 2261 7048 7097 659 8772 4843 4089 4091 860 1999 6662 8841 3091 121340 4318 4322 PMC5932261__F7 Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells 3611 387 5062 PMC5946182__F4 Proposed anti-inflammatory pathways based on reviewed nutritional interventions 4512 3569 1401 PMC5960217__F1 Schematic depiction of the canonical and non-canonical Wnt pathways 7471 7481 7472 89780 7474 324 387 1499 6259 998 PMC5963631__F5 Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response 1967 6133 6161 6122 6167 6209 6228 9669 8663 8894 6208 6205 1968 728689 1975 6229 8666 6171 6230 PMC5964014__F7 Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury 23098 3725 581 PMC5964334__F6 Proposed model of an energy balance-responsive network associated with DNMT1 regulation, DNA methylation and transcriptional regulation of ERA and ERB 1950 7124 3553 3479 1956 54106 3480 3667 6774 5163 1786 PMC5977009__F1 Toll-like receptor signaling pathway 10454 23118 7097 4615 10333 51135 7189 7099 3656 3661 3665 7098 29110 51284 51311 PMC5987683__F3 Mitogen-activated protein kinase signalling pathway 4790 4803 1950 2353 6722 4342 4609 2768 5921 3725 1386 7157 7186 355 10454 4208 929 23118 3315 51295 468 51701 673 5801 5494 3550 7124 7189 PMC5989173__F1 Molecular mechanism of SOCS- and IRF-regulated cytokine signaling in macrophages during ALI/ARDS 3717 3716 9021 3663 PMC5994424__F8 ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 1950 7422 133 3565 55004 383 PMC5995077__F7 DMix regulates hepatic gluconeogenesis in diabetic rats via the PI3K/Akt signaling pathway 3630 3643 2308 PMC5998365__F1 Folate-mediated one-carbon metabolism 1719 7298 6472 4548 PMC5999604__F3 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma 55000 10399 3688 6469 51715 4000 3549 2296 50846 100302203 6497 2683 374654 51684 2736 2737 2735 6608 5727 8643 91653 51203 6790 130497 PMC5999604__F4 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma 23019 6188 2932 2736 PMC6001480__F3 Functional networks in mucinous type epithelial ovarian cancer 5493 23254 9439 22938 10499 4137 4109 7068 1981 5699 5696 5698 5690 55885 4670 8452 79657 27101 6788 1994 PMC6014344__F4 Cross-link between TGFB pathway, Wnt pathway, and ILK pathway 7040 4087 4088 324 4089 847 PMC6015375__F6 Schematic demonstrating of [U‐13C]glucose to CAC and PPP, and protein expression levels in HBP 10724 8473 5132 1431 PMC6016836__F3 Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection 2885 1839 998 25 1633 5058 9459 1785 5163 6714 1399 1956 10096 55970 57180 2774 3682 857 345456 5063 5584 5062 PMC6022934__F8 Urea cycle and pyrimidine de novo biosynthesis pathway 790 1356 1723 8205 162417 5009 PMC6025455__F4 Endothelial targeting to boost endogenous antithrombotic and anti-inflammatory pathways 652070 5091 324 3383 PMC6025799__F2 Roles of IGF2BP1 in promoting and suppressing tumor growth and invasion via regulating different mRNA targets, under the modulation of upstream non-coding RNAs 100126333 10642 4288 5743 5999 5728 960 60 5596 5879 207 717 693210 493812 102723099 PMC6035094__F3 An overview of the cannabinoid type 2 (CB2) receptor system and its therapeutic potential 7097 10333 7096 7099 7124 114609 353376 4615 7187 7189 23118 10010 100187907 10454 5608 29110 2002 3661 5914 6955 PMC6040832__F2 Progranulin, lysosomal regulation and neurodegenerative disease 718 712 7942 PMC6041399__F1 Schematic presentation of JNK signaling pathway in cerebral ischemia/reperfusion injury 4842 572 1843 581 355 8739 PMC6042731__F3 Cell cycle in LNCaP cells after NETD 5885 4089 4193 6502 699 9184 5111 5347 1022 8318 990 4661 999 1869 10926 4087 4088 1017 23594 PMC6047740__F5 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? 22897 5347 55755 4751 1499 2932 324 PMC6047740__F6 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? 1951 1952 51057 6010 4838 5308 2302 57096 324 57216 PMC6048953__F2 Insulin action and resistance in obesity and type 2 diabetes 207 2308 7249 7248 6009 PMC6050907__F4 Neurotrophic signaling cascades 627 2668 1950 4803 5156 2885 1398 2549 5879 2475 387 PMC6055056__F4 FoxO signaling pathway 51701 6502 4193 664 9140 5728 3630 472 57120 1017 6774 10365 2689 3575 PMC6056717__F1 Coenzyme Q10 deficiencies: pathways in yeast and humans 5053 27235 10229 2230 112812 2232 57107 3652 51004 51805 10466 218 57511 3418 PMC6062828__F2 Presynaptic homeostatic functions of calcineurin (CaN) 847 759 1020 PMC6063915__F2 PPAR Signaling Pathway and the Terpenoid Backbone Biosynthesis Pathway 5347 2222 38 3157 6713 4598 4047 6256 1595 10654 51 7108 34 4597 3422 2224 1962 6307 50814 3158 1376 9453 51478 1581 10682 7314 1718 4023 3156 PMC6070613__F8 Triptolide signaling pathway 355 581 1017 PMC6073797__F9 Mechanisms underlying the effects of Stachys sieboldii (SS) 627 4803 581 PMC6076887__F3 MRN complex activates possible (alternative) pathways at DSBs 672 5884 472 1763 9156 9656 675 545 84126 5888 11073 PMC6099188__F1 Bile acids are synthesized in the liver from cholesterol by two metabolic pathways known as the neutral (or classical) and the acidic (alternative) pathways 570 25801 1593 1582 9420 1581 PMC6105527__F2 Cut loose and run: The complex role of ADAM proteases during neural crest cell development 2064 2065 729 847 7020 4609 595 PMC6107379__F1 RAS/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) 3845 6654 2885 867 1431 4763 8036 161742 673 PMC6111343__F7 MiR-146a-5p in the Toll-like receptor signaling pathway 7097 5879 7124 3578 54472 114609 10333 8772 3929 929 23118 7189 7099 920 923 130749 1513 54106 7187 7098 51135 958 PMC6113163__F4 Signaling Pathway of Rho Guanine Nucleotide Exchange FactorImportant functions of this pathway involve antiapoptotic actions and regulation of actin-myosin interaction 6010 11113 9138 5585 85415 1729 5216 6242 5296 6093 9475 4608 5602 397 398 998 10188 3984 8976 7454 6198 5290 5063 8826 1072 4216 5291 10788 1073 5293 PMC6113245__F1 Biosynthesis pathway of HBGAs 2524 2525 140805 PMC6116115__F2 Polymerase-related genes identified using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis 1763 2237 5111 246243 3978 PMC6117394__F3 Mitochondria at the crossroad of metabolic and signaling networks 6478 3845 4609 7019 2475 2597 3939 55902 2194 47 6472 10797 126129 1431 2271 27165 717 6470 PMC6117394__F4 Biochemical mechanisms of oncometabolite accumulation 6935 3417 9817 3418 2271 50 2936 PMC6121259__F5 Signaling pathways involved in TNF/Thy-1-induced astrocyte polarization and migration 7124 7070 6714 PMC6121884__F3 Akt/mTOR pathway in schizophrenia 3084 2066 27185 7249 7248 1020 2475 8408 9776 PMC6132443__F2 Role of NaPiII family of sodium–phosphate cotransporters in the intestines and in the kidney 2260 8074 5741 PMC6137108__F4 Enriched KEGG neurotrophin signaling network following perinatal nicotine exposure in DA neurons 7531 6272 4145 398 396 53358 51135 6654 4215 50964 11213 3845 817 3265 572 11108 5894 5970 1398 1399 5906 3725 581 7161 9092 2549 5596 PMC6143874__F1 Binding of PDGF, GLP-1, IGF-1 and BTC to their respective receptors serves an important role in Beta-cell proliferation 685 3479 2064 3480 5163 1499 324 2146 7249 7248 4193 2308 6934 6009 3651 894 595 1019 PMC6161805__F5 Smoke-induced microRNAs and their target genes 4087 4088 8431 4000 81539 4091 11334 4133 5604 23405 673 604 3605 9289 574451 407020 574031 27190 6209 7494 27161 PMC6173119__F2 Regulation of intestinal cholesterol absorption and role of the Niemann-Pick C1-like 1 protein (NPC1L1) at the enterocyte level in humans 29881 64241 64240 2167 3156 39 95 7038 4547 PMC6176117__F3 Schematic outline of the intracellular signalization in the retinohypothalamic tract 627 847 406 23411 5187 PMC6186045__F5 Regulatory network analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA 64682 6741 9604 79056 64761 219743 3190 9491 7726 2766 7124 6047 PMC6186311__F5 Beneficial effect of RC on hepatic glucose and lipid metabolism signalling pathways 7038 847 5465 PMC6190739__F3 DNA hypermethylation, histone demethylases and histone deacetylases effect on the metabolic enzymes expression involved in glycolysis and glutaminolysis 3099 55818 5728 23081 2475 2203 7428 23410 51548 4609 3939 2744 6510 23409 PMC6196273__F2 Iron chelators modulate multiple immunometabolic pathways via the stabilization of HIF1A 3553 5209 3458 3091 355 PMC6202849__F2 Schema of deriving corneal cell phenotype from iPSCs 6657 9429 5080 79923 4838 652 1445 7020 5077 6662 6663 340273 PMC6208373__F7 Toll-like receptor signalling pathway shows similarities, but also differences between LPS and LPS + IFNG 5277 100187907 8772 23118 3654 1513 3661 7187 7096 7097 5879 7124 54472 3569 114609 929 114034 5132 3665 7189 4284 PMC6209233__F8 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential 7054 4118 4117 210 PMC6209233__F10 Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential 387 7408 3611 5728 2534 126669 572 PMC6213175__F3 Select HCMV gene products that target apoptotic pathways during HCMV infection 8772 581 2475 PMC6214187__F1 SCAP/SREBPs Are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy 1956 355 22937 31 32 2932 3156 23411 3949 PMC6234654__F9 Diagrammatic representation of occurrence of colorectal cancer (a) and various modulatory mechanisms of combinatorial administration of probiotics and celecoxib (b) in CRC with respect to different biomarkers 324 2932 581 3553 PMC6240956__F3 Foamy phagocyte polarization follows a triphasic pattern 3458 3553 3586 3569 383 3603 PMC6247470__F3 Paeonol protects against atherogenesis 948 652 4615 406913 5465 2475 581 3156 355 4015 PMC6260243__F4 JAK1 may be the target molecule of (+)-terrein in the IL-6 signaling pathway in HGFs 2885 6774 7422 1435 PMC6266222__F3 Regulatory effects on immune-related pathways induced by a group of compounds from health-strengthening herbs 5972 3689 3459 3460 3683 2534 2885 3458 567 3303 6890 6891 821 4802 PMC6268691__F1 Biosynthesis pathway for gangliosides 6489 9331 8705 283459 51083 PMC6269430__F5 General mechanism of Wnt induction 648 10600 1029 9055 PMC6270946__F3a Profiling of Concanavalin A-Binding Glycoproteins in Human Hepatic Stellate Cells Activated with Transforming Growth FactorB1 2922 10956 4397 258010 100187907 22926 468 23304 9978 55850 6500 PMC6271057__F5 GSK3B and phospho-GSK3B regulate milk synthesis and DCMEC proliferation via the mTOR/S6K1 signaling pathway 5617 207 2475 595 355 6319 PMC6275309__F1 Molecular pathways of the neuro-immune hemostasis model 2271 5091 324 4179 966 1604 PMC6278486__F3 High-energy donor UDP-GlcNAc is provided by the hexosamine biosynthetic pathway (HBP) and is connected to UDP-GalNAc and CMP-NeuAc 2821 10724 8473 54187 10020 2582 140838 PMC6282995__F1 Retrograde neurotrophic signalling organelles and their main destinations after arrival to the cell body 967 3920 4803 627 PMC6288394__F1 Summary of the potential mechanisms of vaccine NSEs 3553 2475 64127 PMC6289038__F2 Protein–protein network and pathway analysis 4353 8743 10728 1676 80142 239 56616 6916 5742 331 637 5740 5321 9536 240 330 5319 317 5599 27113 1432 54205 329 598 581 5595 5366 7157 5594 5743 836 4170 596 5728 2353 176 207 5291 6382 10018 960 2309 1634 1978 2113 3725 682 1387 5293 7076 112398 7078 1000 54583 8315 1511 5290 4609 5340 112399 4312 2 3558 2475 4313 3091 3569 3479 5294 5328 3587 7124 6385 5578 5970 4318 253260 6714 405 5338 7428 5337 3586 3716 3565 7422 4790 9463 3588 5879 387 197 6804 213 348 51684 4893 351 3958 3265 5320 55662 673 PMC6291477__F2 AHR signaling pathway 196 405 1543 PMC6294838__F7 Signaling pathway of defensins and interleukins gene expression is regulated by PBA in porcine intestinal epithelial cells 1956 7097 7099 PMC6305585__F3 ADAR2-mediated RNA editing in cancer development 6502 406991 407006 407007 267 5911 8038 5101 1314 619501 3490 6581 81 5420 PMC6305585__F6 ADAR2-mediated RNA editing in metabolic disorders 5631 2316 9575 1408 PMC6315507__F2 Intermediary thiol metabolism in renal proximal tubular cells 1497 252843 1630 4945 6648 641 PMC6315839__F2 Model of biosynthesis and signal transduction of jasmonic acid (JA) and ethylene (ET) 64641 1879 81857 PMC6316386__F1 Transient receptor potential (TRP) channels and itch signaling 8989 7442 59341 162514 7223 79054 4018 85480 100313843 3363 1903 3357 PMC6320978__F1 Schematic overview of the Nucleotide Excision Repair (NER) pathway 5887 7507 2067 5111 PMC6321527__F5 Hypothesized mechanism of S5-induced death of human melanoma A375 cells 1956 995 891 PMC6325770__F7 Proposed CLIC4/Arf6 signaling pathway 25932 5494 116986 116987 11021 382 9815 28964 659 5053 PMC6337789__F2 Biological interaction networking of identified HCAECs phosphoproteins in KD 84335 6015 10514 5371 1994 4928 4641 1654 25 4690 10487 7175 8899 5062 6429 9459 51366 5594 5686 10914 25920 5430 10987 8682 1026 51343 2073 9589 800 4171 5175 3315 2010 7414 3678 PMC6343099__F2 Regulated signal pathways and transcription factors of NCX1 in digestive diseases 7220 7225 4088 4089 PMC6350302__F5 Proposed model of PI3K activation in CM-RES clones 1956 3480 5728 2475 PMC6354878__F4 Signaling pathway and GO analyses were performed to identify the biological functions of the subsets of differentially expressed genes after BP5 treatment 324 5478 847 4827 PMC6360698__F2 Molecular signaling of inflammatory pathways involved in structural remodeling 7099 7097 929 8717 7189 4615 8772 4092 4091 23118 4089 29110 5163 8195 3661 2475 51135 4087 4088 4086 PMC6361458__F5 Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients’ skin fibroblasts 100187761 150353 83734 9134 6696 10631 10085 24137 1026 63967 258010 79868 63894 718 51514 5069 220042 3485 PMC6368612__F4 Wnt signaling pathway 7471 1499 2932 324 999 PMC6370815__F7 KEGG cell cycle pathway analysis 10274 5885 9126 1874 4087 4088 4199 9184 5111 1022 1017 990 4661 6502 4999 23595 4089 7851 699 999 PMC6378068__F5 GPL pathway constructed in this study 572 6256 1956 8213 1950 2064 5901 8717 4513 PMC6384818__F6 NOD1 and TLR4 signaling pathways and the main target of CBN in the suppression of LPS-induced inflammation 7099 10392 4615 3553 2919 PMC6385390__F4 Networks representing protein-protein interactions in differentially regulated proteins from the NOD1 (HS578T/NOD1) (a) and NOD2 (HS578T/NOD2) (b) experimental groups 10392 64127 220 55299 79026 9590 6310 23705 3486 1200 10289 6840 115207 6778 2512 6777 6776 79443 5054 2936 10982 26156 79801 3106 10514 10483 6129 84365 221092 23753 6128 27295 23168 6124 5861 6241 4047 6166 23521 29127 6161 4144 5236 5052 6141 51008 25816 9045 6138 PMC6386916__F7 EtOAc extract of L 4157 4286 1638 PMC6387316__F3 Pathways controlling the response of physioxia MSC chondrogenesis 1300 860 6662 176 4322 9507 2308 2309 1280 PMC6388629__F6 IPA network map depicting the DR signaling changes in HBEpCs after 6 h of infection with IAV H1N1 8743 8742 8717 29110 84890 1616 8772 5972 10010 54627 637 835 56616 596 54205 367 6709 2620 397 PMC6389164__F3 The genes and their functional relationships within the RLR signaling pathway 8737 841 8767 7128 4792 207 7706 9636 6352 6347 5970 57506 3627 3593 6885 7186 79132 3320 7184 64135 6772 9641 3439 3665 3442 8517 1654 3661 3445 29110 958 941 PMC6394552__F4 A feedforward mechanism in TGFB signaling 4087 64750 57154 4092 4088 4089 7046 PMC6398583__F3 Control of aerobic glycolysis by ERK and JNK signaling pathways in proliferating cells 673 54625 3939 3091 4609 PMC6400530__F2 Pathogen antioxidant networks: The examples of Mtb and T 4482 7054 25828 324 PMC6409899__F1 Models of replication-coupled ICL repair 4172 4174 4173 4176 4175 4171 57697 55215 2177 84464 PMC6410042__F6 Pathway analysis for PRR and IFN signaling 7097 51284 7098 7099 4615 10392 2444 6041 7124 3458 9118 5915 8651 6772 6773 10379 5696 4599 161247 3659 6890 3434 3437 4938 10581 10410 3430 PMC6425079__F1 Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity 4968 79661 55247 252969 3552 PMC6429175__F8 Comprehensive pathway of Alzheimer’s disease derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) 351 3416 23385 572 842 4023 836 348 317 355 841 637 8772 6622 100506742 1630 22926 7124 840 2932 PMC6433691__F7 Model of JS‐K‐induced anti‐tumour activity in gastric cancer 581 317 6647 PMC6433784__F1 Mechanism of Action of FSH on Adipocytes 2492 1386 7350 PMC6434466__F7 Osteopontin (OPN) stimulated monocyte chemoattractant protein 1 (MCP-1) production and migration of monocytes 3929 929 7099 4615 7189 3550 PMC6436762__F1 Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K 3643 3667 5163 7249 207 5728 572 6009 1977 4170 PMC6441546__F4 One-carbon metabolism 2548 57412 4548 2593 4524 6573 PMC6441662__F5 Fibroblast growth factor receptor 4 signalling pathway in cancer 2264 2885 10818 2549 PMC6443116__F7 Localized decidualization in the cycling human endometrium 5740 9536 5617 3484 PMC6445864__F7 Schematic illustration showing anti-inflammatory responses in RAW 264.7 cells after treatment with AS-6 7099 4615 3553 7124 PMC6447671__F8 PKZ-mediated signaling pathway 10379 3661 29800 PMC6448884__F5 GTS-21 has cell-specific anti-inflammatory effects independent of A7 nicotinic acetylcholine receptors 7124 7099 4615 7186 7189 3569 PMC6458165__F1 Networks related to immune modulation and inflammatory response 5791 84807 49 8795 1510 119 5008 8842 1844 5728 271 PMC6458165__F2 Ingenuity pathway analysis networks related to neurological disease are presented in this figure (A,B) 22936 55422 5447 107966124 9049 4057 PMC6459027__F1 Thiamine metabolism 60386 79178 7086 26061 27010 PMC6478864__F1 Wee1 inactivates Cdk1 by phosphorylation at tyrosine 15 7465 983 6241 891 PMC6480217__F7 Hypothetical scheme of CA action in mammalian cells 57016 9817 4803 7296 83939 468 440 57761 PMC6481742__F1 Schematic representation of the major components of the endosomal pathway and the generation of exosomes 928 967 975 10085 7251 1956 100133941 116844 PMC6482252__F1 Mechanism of foam cell formation 19 2099 3949 948 38 9619 3553 PMC6482252__F2 The physiological generation and function of lipid mediators in immunity 4049 8309 51 4512 26136 PMC6485344__F1 The Krebs cycle 1431 50 2271 4967 PMC6491685__F1 Complement system 717 2271 718 7448 1378 966 727 PMC6497798__F1 Autophagy initiates host immunity and Toxoplasma immune evasion 6714 6774 958 83939 PMC6497798__F3 Targeting of host gene expression by Toxoplasma gondii 6772 8835 8651 6778 3662 6774 958 1958 PMC6503447__F9 Prospective model for clarifying the role and regulation of ATG5 and ATG7 on autophagy and ER stress 9474 10533 22926 83939 468 PMC6506518__F8 Proposed multi-target and multi-component action modes of hawk tea as a previously unrecognized cholesterol-lowering agent 29881 338 3949 4023 PMC6514922__F1 Hypothetical model for the role of thrombomodulin (TM) in mitogen-activated protein kinases (MAPKs) signaling: Thrombomodulin regulates the activation of MAPKs under various pathophysiological conditions 324 5091 2260 2838 1901 387 5879 PMC6517507__F1 Model suggesting the relationships between Th17, Th1* and cTh1 populations and their potential roles in post-vaccination immunity, LTBI and active TB 2833 1235 4280 3553 3603 PMC6519110__F1 Intracellular NAD+ metabolism in eukaryotic cells 133686 64802 349565 23057 55191 93100 952 4860 4837 10135 PMC6520011__F1 Impaired ribosome biogenesis 11201 6135 6125 10993 4193 PMC6526899__F2 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway 6095 790 79603 2595 5569 114880 780922 55832 130951 3258 PMC6526899__F3 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway 4696 4694 4710 4708 4701 729 4724 4718 4715 4728 4702 4698 4729 4704 10975 4714 4711 1340 1349 4720 4717 4709 2109 1537 4722 6392 54205 6390 8802 9512 1345 29796 1431 9973 PMC6530474__F10 Diagrammatic representation of constitutively activated TGF-Beta-signaling-mediated tissue fibrosis 7046 59 7048 6591 7291 2335 PMC6531857__F1 Regulated necrosis: disease relevance and therapeutic opportunities 7124 8717 7186 8737 10454 1540 23118 3550 780896 8772 3552 11035 197259 PMC6531879__F4 Mapping of hits in the MAPK signaling pathway 1610 4803 627 1950 1956 2885 5894 6722 4342 2316 3725 7186 355 1616 4149 929 23118 7189 51295 51701 PMC6533528__F7 Schematic model of IL‐1B‐ and Fn‐fs‐mediated ADAMTS‐12 and ‐7 stimulation by Runx2 and Wnt/B‐catenin signalling modulation in OA‐SF 1311 7477 81792 22943 324 1499 860 3553 PMC6534125__F2 Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention 4087 4088 5077 255967 PMC6538418__F1 Key players in autophagosome formation 596 2475 8408 9706 22863 64422 9474 9140 PMC6539122__F7 Interaction network of proteins involved in cancer, immune system, and signal transduction pathways 1655 6385 9611 5223 55589 1642 7337 1108 4478 1788 7175 9459 25942 2120 983 85477 3611 9252 6932 3098 10672 1487 1843 817 6548 317 1236 7852 818 3065 2113 5579 3725 5777 5335 22821 8607 5305 10746 3606 919 10093 5894 5788 4627 6741 7419 7529 1432 4609 111 5170 841 6890 1794 488 2597 637 975 5052 10109 4689 1508 27071 489 90 23683 6195 6197 4217 8844 8776 5140 5922 5599 998 6850 1436 7410 2771 5294 6774 1021 5567 1147 7874 7186 2767 2782 7532 1857 6777 3320 6632 4628 997 100 10095 1936 5431 5719 5718 56895 151636 5705 5706 5707 10554 8315 5702 5708 7535 695 3689 1536 7417 3635 51135 5606 6500 1500 3306 PMC6540009__F6 Scheme of the effect of pioglitazone on CKD-mediated ER stress in CKD-MSCs 83939 468 55669 4976 9242 PMC6540463__F3 PI3K-AKT signaling pathway which was achieved by DAVID pathway analysis 2475 7249 5879 613 930 5934 5728 572 4193 8213 5478 PMC6542064__F7 Temporal dependence of G2/M DNA replication checkpoint mechanism on the G1/S transition mechanism 9088 1027 4172 6502 1869 983 1026 10926 993 7465 898 8317 902 7027 9133 8318 990 1017 4998 5925 PMC6544365__F1 PI3K/Akt signal pathway is crucial to SDF1/CXCR-mediated homing of endothelial progenitor cells (EPCs) after myocardiac infarction 7852 3383 7412 PMC6548990__F2 TNFR1 signaling 8717 8737 7186 23118 8772 841 11035 197259 PMC6557399__F1 HMG-CoA reductase pathway 6009 11156 6010 998 PMC6558049__F9 Possible mechanism of CAPE-pNO2 inhibits TNBC growth and metastasis 1950 1956 6774 999 7422 1000 PMC6562528__F7 PyCyp protein effects on EGFR signaling in IEC-6 cells 2885 1956 1017 993 PMC6594416__F2 Autophagy signaling pathway 10533 9140 83734 2475 9474 22863 8408 60673 9776 7099 355 596 8772 11035 197259 581 PMC6594416__F3 Endoplasmic reticulum (ER) stress signaling 22926 83939 7186 468 PMC6604150__F3 Differentially expressed genes were labeled in the proteoglycans in cancer pathway in the placenta after IVF-ET during the first trimester by KEGG 920 2002 8009 55486 1633 759 10818 1956 7975 7097 7078 6608 6010 PMC6609682__F7 IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGFB signaling pathway 4087 4088 10410 4089 PMC6610439__F11 NAD(H) recycles (not shown) in redox and dehydrogenase reactions and supplies mitochondria to generate ATP 952 10135 4837 PMC6614411__F4 Pathway-based analysis for glycolysis, TCA cycle and pentose phosphate pathway 6120 9049 4118 472 84890 5225 7851 PMC6621970__F10 Schematic highlighting the signaling cascades that are dependent on erbB4 in MPNSTs 2066 3084 6654 2885 6774 2475 5894 PMC6624447__F5 Canonical pathways generated in Ingenuity Pathway Analysis of interferon signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi 3716 7297 6773 8651 8554 581 3434 6890 5691 10379 3430 128486 10581 3437 140892 4703 831 5696 PMC6627458__F8 Mechanisms underlying the anti-inflammatory effects of oxytocin (OT) on lipopolysaccharide (LPS)-stimulated microglia 7099 22926 3553 468 834 PMC6627586__F1 Scheme of copper and silver distribution in a mammalian cell 540 538 475 6647 5250 10063 PMC6628922__F5 Gestational Binge Alcohol-Induced Alterations in Maternal Uterine Artery Transcriptome 2580 2147 2017 22848 1601 7070 7408 5879 1535 2241 5829 4311 1398 1499 PMC6639196__F4 Conceivable migration pathway related to PNETs based on literatures 4316 10143 2475 11187 3934 PMC6643140__F7 Proposed mechanisms of TRIP13 functions in BCa 9319 999 3397 1956 PMC6651063__F6 DE mRNA corresponding genes in the cultivar “Huoche” under heat stress 1999 574414 2241 80742 80758 PMC6651373__F3 The molecular mechanism of DAPK1 in AD 351 1612 5300 57447 PMC6657153__F7 Schematic representation of Notch1-mediated regulation of Akt signaling disturbed by TDP-∆C protein 5728 3280 4851 PMC6686160__F8 Diagrammatic sketch of the working hypothesis 4087 4088 1003 2305 PMC6687873__F7 IRE1Alpha-XBP1 pathway of the UPR in CF 3569 7124 7099 PMC6698745__F2 Translesion synthesis 5111 11201 5426 5429 51426 51455 56852 7398 83932 PMC6701793__F2 Biological processes associated with up-regulated genes after cecal ligation and puncture and back-regulated by landiolol infusion 3934 2 3178 4258 953 978 4736 3929 7003 7200 9261 54899 197 64781 1390 29 1432 11214 4790 6464 25 5798 64768 11163 1910 94241 1636 9688 10211 5771 11132 3315 4149 6774 6342 9517 340485 5782 4139 54475 2071 2247 3615 4908 6482 641700 753 966 10846 54978 64778 22846 9218 10541 10428 9722 10231 1058 4606 351 622 3162 1621 1452 79658 2017 PMC6701981__F1 Muscle Wasting Diseases: Novel Targets and Treatments 3479 3480 3667 2690 367 6774 9021 7942 2660 4087 4088 28999 587 7124 PMC6710477__F1 Schematic overview of cytoplasmic 60S subunit assembly 134218 51068 3692 79631 51119 4733 55341 9538 100009675 PMC6712555__F2 Vascular inflammation during tumor cell extravasation and metastasis 9546 1003 3383 729230 7422 7412 3553 4317 4318 6347 1380 PMC6719876__F3 Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences 8491 27092 55970 2256 5608 10923 6722 5159 627 5532 783 3727 51701 406990 2353 6789 5871 10000 4215 7046 4149 1432 1399 1398 2885 93589 5578 9344 6197 PMC6719933__F4 Transcriptional regulation of GRINA and its role in cell survival 7421 468 7009 2907 PMC6726207__F1 Small molecules enhance knock-in efficiency 9156 472 675 5893 5888 6247 51199 PMC6727512__F1 AhR transcription in mammalian cells and the putative mechanism of AhR activation 196 8450 27343 11201 57491 1544 1545 PMC6730590__F2 Effects of mutant Kras in reprogramming amino acid metabolism 2746 2806 2805 3845 4190 468 4199 83939 7030 440 PMC6737584__F3 Phosphorylation of central carbon metabolic enzymes 5183 2597 5132 6391 PMC6743306__F6 Proposed model illustrating the roles of CHL1 during NPC carcinogenesis 387 998 5879 10752 PMC6747431__F5 The different expression of HH (hedgehog) signaling 6608 5340 55647 759 6461 PMC6749531__F7 Active constituent-protein targets-signaling pathway network of frankincense–myrrh compound against breast cancer 545 5889 675 4683 4436 2475 5770 1499 999 79728 5743 PMC6770389__F1 The infectious spleen and kidney necrosis virus (ISKNV) induced the changes of glucose metabolism 11113 8050 4118 3418 6120 2271 PMC6770430__F2 Hyperglycemia associated metabolic reprogramming in cancer cells and potential targets 2821 57103 7038 2597 5315 PMC6770969__F6 KEGG AMPK signaling 2147 25886 1080 355 7249 3643 3630 6009 2475 65057 PMC6771624__F5 KEGG pathways for TCA cycle and retinol metabolism in the T 6 vs 50 3420 3421 6392 2271 4190 10901 9227 54884 1544 54600 PMC6779827__F2 Innate immune pathways inhibition by calicivirus infection 57762 3661 2158 1977 PMC6781272__F1 Generalized Toll-like receptor signaling mechanism, adapted from 7100 81793 7096 7097 7099 10333 114609 4118 54106 7098 51311 51284 4615 3654 7189 51135 23118 29110 7187 3665 3661 PMC6798329__F6 Activation of AhR pathway by mycotoxins (Myctx) 196 9049 405 1543 PMC6800061__F2 TARGETING INFLAMMATION IN METABOLIC SYNDROME 338328 4023 3949 7038 7939 7097 1071 4049 4050 4015 7412 PMC6802331__F1 Schematic diagram of the JNK signaling pathway promoting cell death in ovarian cancer 596 581 842 PMC6811614__F1 GCs affect cross-talk of bone cells and their communication with muscle, vasculature and myeloid cell-derived osteoclasts 9242 578 22943 11197 50964 PMC6827047__F1 Parallel outline of several physiological roles of the TGFB/p38, mitogen-activated protein kinase (MAPK), and P13k/AKT/mTOR signaling pathways 1950 2475 1956 5728 5163 7249 7248 6009 4193 2885 PMC6827047__F3 Targeted components of the MAPK and AKT signaling cascades by small-molecule inhibitors in cancer 2475 5163 5728 673 PMC6829385__F1 MAPK signaling pathway: ERK1/2, JNK1/2, and p38 1950 7124 1386 PMC6831629__F8 Hypothetical model to depict the role of Trpc1 channels in linking the inhibition of BMP pathway by noggin, and the activation of Cav1.2 channels in ectodermal cells 7220 7547 6657 PMC6838865__F1 Canonical and non-canonical mammalian autophagy processes 7939 2475 60673 9140 22863 7405 9776 PMC6843432__F4 Coordinated contribution of ROS and BMPs to vascular diseases 860 249 650 4513 27035 50507 7498 836 7189 PMC6859545__F2 Cysteine residues are critical mediators of the antioxidant and heat shock responses 9817 4780 338386 3297 1283 PMC6896088__F3 Associations between the autophagy pathway and MAPK signaling in to tumor tolerance against targeted therapies and chemotherapies 468 9474 10533 440 467 PMC6899468__F2 Schematic diagram showing the inhibition of catecholamine secretion and regulation of cardiovascular functions by CST 4922 107966124 1113 1081 PMC6903684__F1 Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria 1431 50 4191 3418 2271 4594 PMC6910185__F4 A diagram of mechanistic insight of genistein (Gen) to induce apoptosis in cancer cells 7124 355 545 5728 3099 472 637 581 2475 28996 3553 1773 PMC6910185__F5 Molecular targets of genistein (Gen) in cancer cell cycle 1950 4851 1956 995 472 545 1017 983 4193 1869 5728 PMC6910185__F6 Schematic representation of antiangiogenic activity of genistein (Gen) in cancer 5728 7408 387 6010 6714 999 10413 2475 6774 4193 2353 PMC6910185__F7 Illustration of antimetastatic potential of genistein (Gen) in cancer 1956 7099 114609 4615 4318 4094 1728 3553 1386 PMC6915518__F3 Molecular mechanisms of pro- and anti-inflammatory effects of NPs on MФs 10011 8685 7097 10333 7099 7098 51284 941 942 114548 3553 3458 3586 PMC6917641__F1 Drugs with clinical potential in cancer that modulate miRNAs implicated in cell metabolism 3099 3667 494333 2475 6667 6495 9839 6935 2551 2104 PMC6920353__F4 Blood transcriptome profile induced by an efficacious vaccine formulated with salivary antigens from cattle ticks 2833 186 6752 63827 2027 6667 79026 23152 717 624 3977 1230 1956 729230 2056 54106 185 3460 23551 25942 7764 6773 6772 10379 PMC6930181__F2 Metabolic features of healthy and dysfunctional endothelial cells 2539 5209 2597 2194 4200 384 4191 2744 PMC6953032__F3 JNK pathways controlling contradictory responses in neurons 467 1386 2002 6698 221458 PMC6956866__F3 Pue for different pathways 958 3458 9332 383 7852 9474 PMC6963221__F1 Sensing of Dengue virus by the innate immune responses and multiple evasion strategies to hinder the production of type I interferons (IFN).The upper panel shows the sensing of viral infection by RIG-I and cGAS 9641 29110 115004 3454 57762 54464 57506 7706 PMC6964096__F4 Wiki pathway analysis of the differentially expressed proteins (DEPs) during rhesus hippocampal aging 6256 4780 4535 4697 6389 1066 2946 6513 3326 4536 4707 6390 2539 873 2947 4537 4694 6391 2495 2941 3320 6649 4538 4716 6392 2949 5052 4541 4731 2512 23657 4539 4706 4695 4726 4696 4709 4724 6124 6146 4701 6130 6132 4736 6136 9349 4718 374291 6147 6152 4710 4728 4712 4729 6188 6154 6155 6157 6158 6156 6164 6165 6192 6193 6194 4722 6137 23521 6138 6142 6143 4713 6217 6218 6195 4715 4705 6197 6201 4708 4720 6223 6203 6204 6205 6206 6207 6208 6227 6234 4714 4723 4717 4719 6176 6181 9801 2475 1977 2335 253314 5747 51552 5562 7143 3685 7249 5563 3912 3913 57521 1975 2257 3265 2998 3845 6655 4915 3643 5288 2549 208 5934 5728 2788 2790 55970 5294 6812 146850 2782 59345 2889 598 4602 4790 5970 1147 PMC6964670__F2 Analysing IDO1 inhibitors clinical trial results 196 405 3620 4513 6999 3458 8205 8942 169355 PMC6966475__F3 EMT inducers from the chronic tumor microenvironment and EMT repressors from natural anti-inflammatory compounds and pro-resolving lipids 4050 1950 3146 7189 6774 2885 2932 6935 406988 999 23411 1000 2854 PMC6966515__F2 Schematic showing the numerous cellular events which are altered by viral proteins in transformed cells (see key bottom right corner) 8772 998 6010 2475 324 991 PMC6972508__F2 Mode of action of thalidomide and its derivatives in regulating host inflammatory response 22806 3558 4312 3553 PMC6981639__F1 The primary metabolic pathway of mammalian gangliosides 7357 9334 8869 6489 84002 2583 53947 8705 6483 6762 2760 29906 PMC6986718__F3 Impact of genotype, body weight and sex on the prenatal muscle transcriptome of Iberian pigs 2885 7186 1398 2444 8431 PMC6989439__F3 Coagulation cascade related to xenotransplantation 7018 7035 324 5091 7450 PMC7003708__F1 Mass spectrometry–based proteomics of mdx fibro/adipogenic progenitors (FAPs) reveals a significant alteration of key metabolic pathways 25796 1120 1376 1384 1374 1375 3098 3099 5226 2821 37 33 35 5211 2194 22934 6120 5214 1892 1891 226 7086 2597 3030 3032 3033 5230 5223 5224 47 38 2023 2026 2027 50 3418 3419 1431 3420 4191 3421 1738 3939 3945 8050 5160 5162 4118 4967 8802 8801 8803 2271 4726 4695 6389 4698 4696 4709 4725 4700 4724 4702 4701 4718 374291 4728 4710 4729 4712 4713 4704 4697 4723 4731 6390 6391 6392 7388 29796 1327 9377 1329 1345 1347 1346 PMC7005297__F2 Hedgehog signaling pathway in cancer stem cells 6469 5727 6608 2296 51684 2735 2736 5584 864 57758 64839 79805 10013 604 84196 2589 648 7472 595 7291 960 79923 PMC7005297__F3 Targeting cancer stem cell pathways for cancer therapy 960 958 55504 648 50943 28964 1236 PMC7015852__F6 Water lily genome and the early evolution of flowering plants 25913 5212 344022 PMC7016605__F1 The role of the RhoA-ROCK pathway in the pathogenesis of TBI 4099 84894 2049 5728 6010 PMC7017070__F3 Important tumor suppressive miRNAs and their impact on cancer cells 999 693207 3845 2146 7852 PMC7019324__F3 Pathways of macro-autophagy 5163 22863 9776 83734 8408 9140 64422 9474 PMC7019324__F6 Toll-like receptor 4 signalling 3146 4615 3654 7189 29110 3661 114609 7099 PMC7028128__F8 Proposed model linking the miR‐574‐5p locus to the biology of goat mammary epithelial cells (GMECs) 1950 998 4133 5604 10000 9053 6416 2475 581 3725 6194 1975 595 572 1956 PMC7031046__F6 Identification of cancer driver genes based on nucleotide context 10735 567 4615 5426 2068 3105 4893 3845 3265 472 673 3417 55294 6651 5292 23451 5925 4771 7124 6000 2776 1029 2909 6010 6146 4297 196528 324 463 8544 8085 54880 2033 29072 8314 10664 5447 546 4089 7428 5728 5290 84433 1956 3815 2312 2475 2261 2263 4199 PMC7031694__F2 Ionic versus signaling pathways for cardiotonic steroid effects 1950 1956 6714 PMC7037830__F4 Illustration of TLR4 signaling pathway 7099 3656 3654 51135 7189 10454 23118 7187 29110 3661 4615 114609 PMC7038996__F7 Two-step mechanism for SSB end resection in SSB repair and signaling.Step 1: An SSB is recognized by APE1, which then initiates SSB end resection in the 3′–5′ direction to generate a small gap (this work) 6741 5111 545 51199 PMC7041777__F3 Interactions between AB, WNT pathway and energy metabolism in AD 4040 4041 1499 3939 8050 324 PMC7046546__F3 Signaling due to A 3458 4284 3383 100506013 PMC7058704__F1 Autophagy process 9140 83734 9474 10533 64422 9776 60673 100170220 PMC7060278__F4 KEGG maps analysis 8453 7428 5155 978 2147 4018 29984 27289 387 2242 5810 PMC7060278__F7 LPA metabolism, KLHL and KCNE3 as novel EMT controller genes 10008 4018 4099 4026 3784 5338 5337 5091 57565 3745 PMC7065707__F2 Cell cycle in stem cell proliferation, pluripotency and differentiation 6657 79923 983 1017 5925 PMC7065707__F4 Cell cycle in stem cell proliferation, pluripotency and differentiation 9134 595 6657 5933 3280 PMC7073173__F2 BMP signaling pathways 655 331 2475 PMC7073720__F4 Prostaglandin biosynthetic pathway 4512 4513 717 5740 9536 5730 5226 PMC7075706__F4 Intracellular pathways involved in proinflammatory effects of soluble uric acid 2475 3553 3552 3569 114548 22900 PMC7081333__F8 Piscidin-1 anticancer signaling pathway 6648 51024 55669 9927 4976 PMC7096357__F1 Co-regulation of Hippo and Hippo-like signaling pathways by Mob family proteins 25843 4485 81532 11329 26524 PMC7096376__F2 NAD biosynthetic pathways 10135 93100 203447 23475 PMC7140893__F6 Gene–gene interaction (GGI) and protein–protein interaction (PPI) predicted networks of DEGs enriched in the extracellular exosome post heat stress 27230 6277 7431 3384 6275 2335 10728 7045 3958 7070 1794 3313 929 55619 140885 55748 10672 10631 2790 6696 335 3827 336 2243 1 197 213 2244 259 3315 350 1604 10381 3483 3700 7277 3326 3320 3337 27040 10808 3301 PMC7167271__F9 PPI plot of IR and fatty acid oxidation 2475 2170 31 3418 5264 PMC7176996__F5 Involvement of angelicin in several apoptotic pathways which promote cancer cell death 2475 1956 8772 317 PMC7186402__F1 Classic control network of ferroptosis 23657 6520 2729 2730 55240 2937 7417 50508 5093 5094 2539 145258 3315 55847 5212 2182 10162 3156 PMC7188049__F3 Role of ACE2 (angiotensin-converting enzyme 2) in the pathogenesis of coronavirus disease 2019 and the inflammatory response 59272 545 6868 7113 PMC7189445__F1 Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAcylation 2821 5238 6675 55577 8473 10724 PMC7193099__F2 Hippo pathway in heart development and homeostasis 4485 60485 57551 9113 26524 PMC7199433__F1 Mammalian kidney development 130497 3975 10736 2625 2297 7849 2138 7490 2668 5979 6495 PMC7210543__F3 Scribble complex in immune cells 56253 998 7535 920 3458 PMC7210752__F1 Proposed model for the regulation of pistil growth and ovule primordium initiation 51411 5300 108348016 5863 PMC7214151__F3 Interaction between Rap2‐Hippo‐Yap1 pathway and TGF‐B signaling 7048 4087 4088 4921 9113 26524 4089 5654 1499 PMC7221190__F2 Complement-driven accelerated renal senescence after IRI-AKI leading to CKD progression 1356 718 23379 7804 4041 1499 1431 7039 PMC7222183__F1 Main mechanisms in ferroptosis 367 2937 8031 2879 2936 246 2182 10162 100 PMC7223478__F4 Several major mechanisms that have been implicated in vascular aging 183 1906 1636 387 6010 56920 2638 PMC7224341__F1 Compartmentalization of adenosine biochemistry 100 84890 203 4860 PMC7226610__F4 P53-related miRNAs controls the osteoblastic differentiation through interplay with Notch, Wnt/Beta-catenin, and Sonic/Hedgehog (HH) pathways 4193 6657 7422 6608 4853 4851 2535 51176 2735 847 23462 860 3727 1499 PMC7230310__F6 Knockout of IRF7 Highlights its Modulator Function of Host Response Against Avian Influenza Virus and the Involvement of MAPK and TOR Signaling Pathways in Chicken 7189 3716 3717 6772 6773 29110 3665 3606 10898 4599 PMC7232389__F6 Eukaryotic initiation factor 2 (EIF2) signaling pathway 8664 1974 5725 23551 5898 8663 6130 6101 22808 6193 6227 6206 6187 6136 6229 6188 5906 6228 5899 10000 6137 6207 6203 6201 9775 6688 9045 6194 6171 6170 6231 2197 6169 5289 27161 6202 6133 6158 6132 6124 6128 2885 207 472 27335 6129 6155 8667 208 5287 6144 10480 26523 5296 6122 50507 PMC7232389__F7 Sirtuin signaling pathway 51025 5465 3297 6389 55902 6390 5213 22933 6392 5468 47 5481 6391 10533 351 3939 2475 10105 4846 9136 22863 PMC7232496__F7 Postulated mechanism of disease resistance in cattle to PPRV—Schematic representation of roles of differentially expressed genes 7098 3437 3433 9636 2537 3665 10379 3661 51284 201626 3434 PMC7237311__F5 Brain proteins identified to be interacting with GFP-CASK through GFP-Trap mass spectrometry analysis are plotted using the STRING database interface 6645 26227 1302 1737 54769 56886 1845 3329 9049 18 136319 6500 284069 324 488 347733 10423 23649 49 55327 84617 10381 2011 478 9615 1400 2596 85455 8573 4131 5928 4135 PMC7246457__F5 Network analysis of proteins related to inflammation-driven pathology of ARPE-19 cells 5162 847 1499 3939 5563 283149 4524 4507 2744 875 2730 2876 607 79888 6597 6720 5335 5447 5595 1956 1491 8772 11151 100187761 6667 3159 5580 3267 6654 100506658 3315 3297 5894 1965 5771 5295 83700 355 4312 6714 PMC7246552__F1 Summary of methyl and methionine metabolism 2548 4397 635 2593 10400 4524 5091 875 PMC7247011__F3 Fe-responsive proteins with relevance for photosynthesis in Cyanobacteria, Chlamydomonas, and land plants 2241 2242 5091 847 4666 2530 PMC7249327__F3 From progesterone to Cdk1 activation: the scattered elements of a not fully understood signalling pathway 10776 4342 4661 9896 983 PMC7249327__F6 At the top of the signalling pathway, the critical Arpp19 dephosphorylation at S109 by PP2A-B55D 10776 4342 983 PMC7259377__F6 GLS1-mediated reduction of oxidative stress is associated with increased phospholipid synthesis and the activation of folate and methionine cycles 27232 4143 4144 27430 10588 635 4524 875 1491 2937 7038 10400 5833 9791 23761 81490 PMC7260598__F2 ACE/Angiotensin II/AT1R and ACE2/MasR axis 50943 920 1636 59272 7099 7097 54106 PMC7272522__F2 Antioxidant and detoxifying processes involved in genoprotective activities 6649 196 9817 405 6647 6648 PMC7276545__F2 Examples of life science networks 847 5900 7018 6476 PMC7277573__F3 “Clathrin-coated vesicle cycle” pathway was enriched in both sexes 8301 51429 3092 274 8674 4905 27342 375 6844 8411 10652 847 9648 6845 8673 10113 83547 PMC7279287__F1 Synthesis of butyrate in E 727 355 3045 100187828 PMC7279373__F1 Interplay between reactive oxygen species (ROS) and the central carbon metabolism 2539 2597 5163 4199 PMC7279580__F6 Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions 1950 5223 3479 7076 55364 PMC7281533__F4 Reactive oxygen species (ROS) promote cellular inflammatory response and oxidative damage, which may impact cell and tissue viability in the lungs 581 5212 9817 PMC7281690__F1 Role of WNT/TGFB signaling pathways in pathogenesis of cardiac fibrosis 7045 7046 4087 4088 4092 4089 324 PMC7285825__F11 Ingenuity pathway analysis of functional relationships among genes involved in the IFN signaling pathway 3458 7297 3716 6772 6773 8554 10379 581 3659 PMC7286274__F3 Putative signaling effect of ⋅NO on nodule development 108348016 51199 51225 PMC7287924__F1 Model Schematic 961 6714 11113 PMC7290425__F2 Breast cancer cells use HSFs to drive various tumor-promoting mechanisms 3297 3298 10195 51278 3299 3091 23011 PMC7290425__F3 Hepatocellular carcinoma (HCC) cells use HSFs to promote metabolic reprograming and cancer invasion 3297 8434 3099 3298 2203 3299 3091 3939 10919 PMC7290605__F4 Schematic diagram represent the Putative mechanism of HPV in breast carcinogenesis 4799 4513 6714 672 PMC7290664__F6 Functions of caspase-2 in DNA damage and cellular stress 545 472 983 637 596 581 4975 PMC7291824__F4 Ingenuity Pathway Analysis of gene networks 30837 3458 57823 939 4668 7024 3717 7462 613 64762 116835 9212 9767 6195 375790 3106 6197 5604 8516 963 9214 23224 1534 26994 10106 974 53947 55840 3484 57575 64170 5225 55450 2528 8473 79930 977 2681 51237 84329 55870 23035 11135 3512 7869 10628 56829 3397 51028 6504 5786 5774 9191 221037 50615 608 22882 8555 368 2833 695 79465 6777 6776 310 285966 128853 5794 5210 55959 4240 54915 2952 51311 51284 83594 11117 54903 23295 26985 54209 1314 56246 23138 PMC7297083__F2 Interaction between pattern recognition receptors (PRRs) from dendritic cells (DCs) and VLPs 2241 7097 941 PMC7312564__F2 Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis 1050 729 727 PMC7312732__F2 TRPV1 induces proliferation through Ca2+ entry, ATP release and membrane P2Y2 receptor activation, and the transactivation of epidermal growth factor receptor (EGFR) 1956 7442 6714 5163 5164 PMC7324687__F2 Dopamine interaction with adenosine and NMDA signaling 8864 5187 3725 PMC7326806__F3 Overlapping molecules in cancer and neurodegenerative diseases 351 581 595 5300 2932 1017 1728 PMC7327986__F5 NRF2 signaling pathway in the context of environmental pollutants induced redox toxicity and its regulation 367 1956 5728 9817 3297 PMC7328045__F1 Proposed inhibition of SARS-CoV-2 entry/replication by intervention at the NPC1 pathway 59272 7113 4864 PMC7335630__F2 Immunological response of SARS-CoV-2 7113 59272 1636 7124 961 PMC7343132__F3 Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection 7097 5879 7124 54472 8772 114609 3929 929 23118 958 948 7189 130749 3661 PMC7352703__F4 Enrichment Kyoto Encyclopaedia of Genes and Genomes (KEGG) analysis of DEGs engaged in the Notch signaling pathway 342371 1387 2033 8650 3280 388585 100188776 23385 6310 PMC7352853__F2 Sphingolipids implicated in pulmonary fibrosis, their structure, and metabolizing enzymes 2531 10715 253782 91012 204219 29956 79603 8877 56848 8560 PMC7352853__F6 Role of lysophosphatidic signaling via lysophosphatidic acid receptors in pulmonary fibrosis 4018 7049 4088 4087 6010 4089 1264 PMC7356262__F11 Schematic figure of the NFKB signaling pathway and inhibition of IKK complex after treatment with VA 3553 4615 8717 3654 51135 7186 7189 6352 PMC7365123__F1 Putative association between ACE2 shedding after SARS-CoV-2 infection and the poor outcomes in elderly COVID-19 patients with pre-existing age-related cardiovascular, cardiometabolic and cardiorenal diseases 59272 7113 2475 PMC7373735__F1 General mechanism of ferroptosis associated with lipid, amino acid, and iron metabolism 1356 100 55240 10162 4015 8031 2879 PMC7376803__F1 AMH and FSH signaling pathways, cellular outcomes, and main functions in IVF practice 268 269 2492 4086 4090 6714 1499 4091 4089 2308 3196 4313 8520 1017 PMC7377942__F7 Mechanism of metformin‐mediated improvement of mouse oocyte apoptosis defects induced by arecoline 847 2876 6647 6648 7001 9588 842 836 581 PMC7386875__F4 Treatments for targeting coronavirus disease 2019 (COVID-19)-associated thrombosis 3146 7113 59272 PMC7392272__F2 Identifying the key regulators that promote cell-cycle activity in the hearts of early neonatal pigs after myocardial injury 4771 122786 79981 11186 60 71 60485 6788 84962 8994 166824 1855 1857 1856 1453 1454 25937 9113 26524 55233 92597 4092 2932 10413 1499 8313 8312 324 10297 7159 8945 23291 7003 8463 7004 7005 4087 4088 4089 4086 2736 3689 174 2246 5054 4609 595 6657 6591 PMC7400965__F3 SHARPIN regulates multiple signaling pathways in tumorigenesis 5077 4286 6663 10419 81858 4193 5728 PMC7403357__F3 Bioinformatics analysis of data 60675 6672 3263 4192 5579 2159 3479 3627 1437 10562 1894 53637 10068 199 58498 4745 3684 57674 355 90161 4693 8038 7291 6850 6402 3690 3815 83706 1380 8862 10507 415116 284194 5580 5552 3055 28984 7704 5371 PMC7404026__F1 Canonical and non-canonical Nuclear factor kappa B (NFKB) signaling pathways 613 4049 4050 958 6850 3932 7535 4615 695 8717 7186 7189 8915 5966 5971 5970 PMC7405837__F4 DEGs in RPE cells of ATP-producing pathways 6389 6392 9049 4696 4694 100499532 1353 5163 5164 5161 5165 5166 50 3420 3421 3418 4967 8803 PMC7405837__F7 DEGs in RPE cells of the glycerophospholipid metabolism pathway 2819 57678 84803 137964 150763 4018 10554 10555 56894 1040 8760 23175 686 32 5337 55022 57104 5320 5091 254531 81490 10390 56994 5833 9468 55224 PMC7419982__F5 Sodium (Na+) and potassium (K+) ion homeostasis by SOS pathway 207 6654 6655 PMC7431487__F1 Antiviral signaling pathways induced during viral infection 9636 7098 51284 51311 4615 57506 7189 7187 10010 3659 29110 3661 3663 3665 PMC7432101__F1 Cartoon representation of DGK signaling in cancer 2475 595 3091 6010 6714 4609 PMC7438746__F3 Indirect transcriptional control by AMPK through metabolites of intermediary metabolism 51548 80312 200424 54790 8473 10724 PMC7451565__F5 Genome-wide association study for mammary structure in Canadian Angus cows 5125 1749 6556 1272 5179 7429 5791 25953 5468 10109 151306 5801 124274 417 PMC7456893__F1 Canonical and the non-canonical Wnt signaling pathways 7482 7473 7472 7471 7474 89780 54361 7475 80326 7483 7480 7476 81029 7481 1499 324 2932 387 607 1386 960 4513 PMC7457231__F1 TGFB–SMAD pathway in the basal and activated states 4089 1024 1025 PMC7460314__F2 Key pathway of adipose metabolism 5465 4023 2167 355 7038 95 PMC7460588__F1 Canonical Wnt signaling pathway 84133 54894 4040 4041 6477 324 607 51176 595 22943 PMC7461575__F4 Integrates stress response (ISR) in the context of muscular disorders 7072 10146 468 PMC7465958__F2 RasGRF2 as an effector of AnxA6-mediated TNBC cell growth and motility 1956 309 998 5924 PMC7472745__F5 G2/M cell cycle arrest and mechanisms by which it is affected by Vpr 9730 5347 146956 545 472 PMC7493015__F3 Arachidonic acid (AA) metabolome and abnormal class switching in CF 4513 4512 717 4048 PMC7493015__F5 Ion transport regulation by LXA4 and RvD1 enabling the restoration of ASL height in CF human bronchial epithelial cells 435 5032 2358 24145 PMC7494970__F2 Involvement of Ang-II, ACE2, and Ang-1–7 in atherogenic pathways 59272 3383 6868 79400 50507 387 PMC7509150__F5 KEGG analysis for signaling pathways 6476 27040 472 29760 4067 613 8717 331 3929 929 114609 4018 958 7187 7186 7189 4049 4050 8772 2919 7054 3725 2353 4314 3976 7124 64127 6401 256933 PMC7509416__F1 P38 MAP kinase signaling pathway 23118 466 1742 2932 PMC7509416__F5 p38 functions in neurological and psychiatric disorders 6647 7442 4485 10519 PMC7517653__F6 SFR changed substrate metabolism in ruminal epithelium 3099 8789 2167 1591 1718 1281 1277 50814 1278 1289 PMC7520308__F1 Biosynthetic pathway of tetrahydrobiopterin: de novo pathway from GTP and two other salvage pathways from sepiapterin and 1′‐hydroxy‐2′‐oxopropyl‐tetrahydropterin, respectively 367 6697 1719 PMC7527441__F1 Major immune response pathways after helminth infection 85480 64806 374 90865 383 8178 4586 PMC7533754__F1 Mechanisms involved in gut microbiota-host communication 940 50943 114548 PMC7537138__F4 SARS‐CoV‐2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors 85451 59272 6714 183 183 6714 847 59272 PMC7539288__F2 Subcellular equilibrium of NAD+ 2539 65220 23057 64802 4199 6647 349565 10873 57716 3418 3417 23530 PMC7539288__F6 NAD+ deficits in aging-associated dysfunction and cancer 952 9575 2308 10135 3417 PMC7544845__F6 Druggable signaling cascades in vasculitogenic T cells 3558 4851 940 920 7535 5728 5163 3280 PMC7550629__F3 TRP- small GTPases signaling pathways interplay in aberrant tumor vascularization 7220 59341 7225 79054 387 1003 PMC7564605__F1 IGF-1 signaling pathways 3479 3483 3480 3667 4087 4088 4090 4086 5728 5163 4089 2932 7249 7248 6009 664 1499 1977 8408 PMC7585181__F2 Participation of SUMOylation in molecular signalling pathways involved in atherosclerosis 59343 5465 5970 PMC7588592__F2 New molecular targeted drugs 1956 7432 3383 PMC7589192__F2 Common signaling pathways of epithelial-to-mesenchymal transition based on Albrecht et al 790 847 6010 PMC7591852__F3 Dopamine-induced interactions of female mouse hypothalamic proteins with progestin receptor-A in the absence of hormone 4199 7296 5052 25824 5213 3939 7001 5236 9588 2271 5315 27344 4191 5162 1737 4190 3419 50 1738 PMC7596389__F9 Schematic presentation probable protective mechanism of Ursodeoxycholic acid (UDCA) against As(III)-mediated hepatic injury by activating the Nrf2 pathway 842 493869 836 847 3162 581 54205 6647 1728 7157 9817 596 4780 PMC7598701__F10 Differentially expressed genes involved in the p53 signaling pathway were annotated by KEGG 1017 472 545 637 4609 842 94005 4193 64065 84883 5728 6477 64326 PMC7599793__F1 Summary of Wnt/Beta-catenin, Hedgehog and hypoxia inducible factor (HIF) pathways and their downstream mediators in the liver 3091 7484 6469 3549 7472 4040 4041 1499 324 7428 51527 51684 2737 2736 405 595 2752 8974 79923 6657 6662 607 196 117581 PMC7606110__F1 Current regulatory model of Wnt/Beta-catenin signaling, and the Wnt-targeting natural compounds which are currently under investigation 324 1499 26959 960 607 PMC7611882__F4 Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation 2628 4953 56603 84002 6483 1120 56624 253782 790 23761 54344 5327 444 2131 411 5289 11019 401494 29956 79993 226 55577 2582 2098 4522 8802 3098 5223 50 1892 3074 1608 217 5422 3034 27034 1629 8813 85365 34 83440 161823 158 10714 4860 5447 594 2987 873 383 80347 29968 683 952 PMC7646980__F10 Anti-inflammatory effects of BBR on LPS-induced inflammation via suppression of the TLR4/NFKB and MAPK/AP-1 pathways 929 7189 10454 51295 7124 4513 3553 4615 6761 59307 7099 3656 51135 4118 3654 54472 PMC7654574__F8 Protein–protein interaction networks of energy metabolism canonical pathways affected by AgNPs/CDDP exposure in HepG2 and THLE2 cells 1738 25828 1962 3033 5045 6392 6648 173 54205 2180 2879 23385 48 50 5211 230 7167 2597 5313 43 2023 2821 8942 5315 39 PMC7654574__F9 Protein–protein interaction networks of the sirtuin canonical pathway affected by AgNPs/CDDP exposure in HepG2 and THLE2 cells 102 4720 2551 4790 351 2475 207 4729 2539 581 19 4713 23411 22933 5970 6648 1537 3418 6390 4722 23410 26519 328 4709 10135 7417 51547 100287932 7508 7416 26517 5481 PMC7658481__F6 Pioglitazone effects on TLR and interferon (IFN) pathway 3454 3455 7097 7099 4118 8554 4615 6772 6773 29110 7189 23118 10379 3661 3665 9636 11274 PMC7669638__F2 Molecular Regulation of Cdk5 activity 4803 627 2668 2534 1020 2674 1958 PMC7674659__F4 Mitochondrial carnitine shuttle, one-carbon folate metabolism and trans-sulfuration pathway 355 1374 1376 23152 2731 441024 6472 81034 94081 54977 6470 4522 10840 635 PMC7685174__F1 Balance of angiotensin (Ang) II and Ang-(1–7) in the renin-angiotensin system (RAS) 1636 59272 120356740 PMC7693401__F2 Toll-like 4 receptor signaling in MCs 929 7099 2534 4615 9341 4067 51135 3654 7189 7124 8773 1386 PMC7693401__F3 Control of TLR4-mediated signaling in MCs 7099 4615 51135 3654 7189 8651 9021 1386 8773 PMC7698939__F1 Tryptophan metabolism through the kynurenine (yellow), serotonin (blue), and indole (purple) metabolic pathways 8564 8942 15 438 PMC7704201__F1 In the insulin signalling pathway, insulin attaches to insulin receptors triggering its dimerization and the intracellular autophosphorylation of their tyrosine residues, which constitute an attachment for IRS proteins 5163 5266 3667 8660 6648 PMC7705761__F4 Identification of key gene networks controlling organic acid and sugar metabolism during watermelon fruit development by integrating metabolic phenotypes and gene expression profiles 5183 1431 1611 PMC7708378__F4 GHR activation and signaling 4067 3717 3667 3135 PMC7715027__F2 Transcription regulation and consequent tissue functions in hypercapnia 3418 6387 1805 5966 387 7124 9547 596 100861532 PMC7726878__F1 TLR-mediated signaling pathways in response to HSV 7099 7097 7096 10333 1956 7098 4615 54106 23118 3661 3665 PMC7736628__F1 Consequences of STING over-activation on antigen presenting cells and T cells following severe acute respiratory syndrome coronaviruses (SARS-CoV-2) infection 59272 57506 115004 6573 3437 3661 29110 3665 8408 7124 55922 PMC7744622__F3 Major signaling pathways involved in the regulation of autophagy 2475 5728 64223 253260 5163 6009 7249 7248 8408 14 9776 55626 22863 60673 5266 PMC7755516__F2 Lytic cell death pathways of intestinal epithelial cells (IECs) during the intestinal diseases 7124 8772 8737 11035 114548 834 197259 79792 2879 3553 PMC7756907__F1 One ring to bring them all and in the darkness bind them: The Trafficking of Heme without Deliverers. 9332 3263 4035 3240 2597 9429 55640 PMC7758401__F1 Establishment, maintenance and erasing of 5mC in plants 26136 192670 27161 PMC7760347__F2 Mechanisms governing bile acid (BA) enterohepatic circulation 151306 2264 5697 9965 PMC7761504__F1 Wnt signalling pathways 22943 4040 4041 6259 57216 324 998 23002 387 1499 3725 PMC7762487__F8 PPI network and KEGG pathway analysis for the differentially expressed MAM proteins in PSD and PDZ rats 4513 830 23673 10972 1509 5594 2597 5898 55970 5315 5660 5708 4536 1917 4747 220296 4099 4974 9218 391 348 8139 79135 PMC7762545__F3 The conventional Kyoto Encyclopedia of Genes and (KEGG)-determined ccRCC pathway in the three cancer nodules with respect to the normal tissue from the right kidney 6513 2033 1387 7422 5155 7039 2034 3091 405 9915 9978 7428 54583 112398 112399 8453 7042 7043 PMC7762545__F4a Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach 3265 3845 56848 5578 5579 5894 5604 5605 5321 9047 5336 5530 5532 5533 5534 4773 5743 25759 5747 3791 7422 5829 998 351 3315 6714 5290 5291 5879 5880 5881 4846 5293 5295 5296 208 8503 10000 842 572 PMC7765462__F10 Scenarios of SK3-Orai1 interplay 10280 857 84876 6786 PMC7767241__F1 Diagram highlighting prominent pre- and post-transcriptional interactions between NFKB and the Lin28/let-7 pathways 6774 5970 5971 3569 389421 79727 4609 PMC7767977__F1 Illustration of the neuroprotective pathways following GHS-R1A activation by AG or ghrelin agonists in neurons and astrocytes 7249 7248 8408 9706 10533 9474 23411 2597 7351 55669 9927 581 3569 4899 7019 PMC7769847__F3 Overview of crosstalk pathways associated with Osx 860 847 7704 1277 1749 4488 4782 5167 221044 100379198 50964 4040 4041 PMC7770202__F1 Signaling pathways of interest in the peripheral and central nociceptive pathway 8989 7442 467 4852 796 6863 4790 5970 627 4803 4513 3553 10267 6869 PMC7773816__F1 Role of amino acids and amino-acid catabolizing enzymes in T-cell activation 3718 196 2638 PMC7773816__F3 Effect of amino acids and their derivatives on T cell signaling 27040 3932 7535 4609 468 PMC7782450__F3 Amino acid catabolism caused by ARG1 and IDO triggers a shortage of l-arginine and tryptophan, disturbing the homeostasis of host tissues 383 83939 2475 468 PMC7784643__F1 Canonical and non-canonical signaling pathways of AhR 367 6714 405 196 PMC7786191__F2 UPRER and UPRmt mechanistic commonalities and differences are described in this figure 83939 22809 8192 22926 7494 PMC7787054__F3 Signal transduction pathways regulated by RIT1 6016 998 5879 5058 572 5163 3091 57139 5899 5898 2885 1950 3458 4803 3479 8452 8216 PMC7793864__F1 Cartoon summarizes intracellular pathways used by cancer cells to support increased citrate synthesis in mitochondria 3939 47 5091 29968 26227 PMC7796135__F1 Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis 7124 6772 6774 4513 PMC7796305__F3 Role of the Renin–Angiotensin–Aldosterone System in Dystrophin-Deficient Cardiomyopathy 1636 59272 4087 4088 4089 PMC7796397__F2 Two major RNA export receptor pathways, nuclear RNA export factor 1 (NXF1)/nuclear transport factor 2-like export 1 (NXT1) and chromosome maintenance protein 1 (CRM1), are shown, and both are dysregulated in cancer 5902 7175 5903 56000 11219 29107 10482 23636 8480 9972 PMC7797159__F6 Cis- and trans-networks of DEGs and DE-lncRNAs of muscle development-related GO terms and signaling pathways 6473 54361 2885 6654 51701 5908 57551 51347 207 1399 1850 2005 27330 4208 6722 PMC7808269__F4 c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy 7124 6367 4049 7292 6347 9636 2921 414062 3569 56833 6372 4318 3627 6351 2841 54210 8685 7412 5795 971 2687 1441 1803 958 27180 2357 160364 2358 6275 7846 26228 115727 9111 6279 11151 64411 6280 27306 2268 595 4210 11277 4791 6352 7852 383 1583 1051 1649 7436 2167 114907 PMC7808269__F5 c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy 3934 348 3592 50604 3624 4318 5054 246778 1116 3553 23452 3593 3606 3586 6347 5328 1440 3240 3441 5196 3487 4057 6354 5657 3600 3456 1462 1356 629 1437 3082 1991 100506736 7057 8743 182 10544 10581 9153 928 3558 7096 2697 3693 3111 958 53831 79865 4615 3676 8807 4082 5359 940 214 1880 23308 3791 7412 1232 1439 79132 1075 8564 129607 4940 84166 5698 8638 5272 8942 91543 4843 2634 2549 205 3067 1734 5696 9641 4616 11274 115361 9023 163351 1992 3433 2119 4094 6737 10538 4609 103 3662 10123 3669 11040 6772 25819 3659 146857 5371 3725 3665 1850 6256 678 10379 6775 1616 80824 894 1647 5966 55388 6773 4599 4600 3097 PMC7811571__F1 Graphical abstract 7808 7099 59272 114548 3553 PMC7814318__F1 Wnt pathway 999 1499 324 387 998 PMC7815415__F5 PPAR signaling pathway of potential targets of allicin 335 5360 4023 4312 3611 7316 PMC7816800__F6 Functional interactions between genes under positive selection in the NF-ĸB signaling pathway (ingenuity pathway analysis, IPA) 1950 4803 4049 958 114609 100187907 8717 5971 3066 PMC7820019__F8 Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24 717 7249 7248 2475 PMC7821223__F4 Hsf1-regulated gene network 3337 3312 351 10808 3297 3315 9531 55466 1410 3301 PMC7824059__F4 Top-ranked and interested pathways in Holstein and Jersey cows 7124 857 858 859 777 776 5023 8717 7189 23118 257397 10454 10105 2353 4792 3553 5743 3371 3383 2920 1906 2921 PMC7824851__F4 PTEN modulates cell survival and proliferation by suppressing PI3K/Akt signaling 5728 4193 10000 2475 PMC7825147__F2 Tumor suppressor and promoting effects of the TGFB pathway 4513 1956 5884 472 51129 3399 3397 3398 581 331 324 PMC7826840__F4a Analysis of the Immune Responses in the Ileum of Gnotobiotic Pigs Infected with the Recombinant GII.p12_GII.3 Human Norovirus by mRNA Sequencing 3383 942 958 941 940 2885 29851 920 7409 2625 11009 PMC7827874__F4 Endothelial to mesenchymal transition (EndoMT) in PAH 1003 7075 7450 1000 4313 4318 PMC7837452__F7 Iron-Sulfur Cluster Biogenesis, Trafficking, and Signaling: Roles for CGFS Glutaredoxins and BolA Proteins 9054 10539 5093 2242 552900 57019 4682 27158 PMC7840460__F7 Dmrt1 repressing immune response but promoting proliferation of mGSCs 7124 7099 1761 7187 595 3661 7189 PMC7847674__F2 Signal transduction mechanisms activated by ovarian steroid hormones on endometrial autophagy 5241 7018 4513 8408 PMC7848966__F4 Crosstalk of the NF‐KB pathway involved in glioma angiogenesis with other signalling processes 7124 7186 331 9966 10682 PMC7849182__F8 Schematic showing multiple signaling pathways of HSYA 7099 3717 54472 4615 6955 2147 2475 2885 1616 PMC7849461__F2 Renin-angiotensin-aldosterone system 59272 1636 4088 3553 PMC7855940__F1 Multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease 3091 6774 3552 7515 2237 5111 11284 PMC7862565__F24 Molecular signaling pathway 7099 8772 4609 581 7124 PMC7882969__F2 Signal pathways related with androgen synthesis in polycystic ovary syndrome (PCOS) 54361 3643 2932 324 1499 367 6770 1583 1586 3284 PMC7883806__F1 Wnt signaling pathway 4040 4041 4920 4919 324 2932 23002 5879 387 1499 PMC7884184__F3 (1) The role of the PI3K-AKT signalling pathway in antioxidative stress related to radio- and chemoresistance 5728 7249 6009 PMC7891831__F1 Enzymatic cascade of the renin-angiotensin system (RAS) and the key receptor systems 59272 1636 367 PMC7893118__F1 TGFB signaling 2885 4087 4088 4091 4092 4089 PMC7895420__F1 Molecular pathways control protein synthesis and degradation in skeletal myocytes 207 3479 2475 4089 4088 4087 55626 PMC7897195__F2 SFRP2 and the canonical Wnt signaling pathway 4040 4041 324 1499 6423 PMC7900405__F6 Schematic illustrating entosis and the actin machinery 998 5099 387 6722 5879 PMC7901941__F1 Characterizing oligodendrocytes throughout the lineage 6663 116448 5156 2581 4340 4155 4099 PMC7902093__F1 Environmental mechanisms of orofacial clefts 196 4851 4853 431707 4487 4488 PMC7903655__F2 Mechanism by which MSCs regulate macrophage polarization in the context of SCI 383 3566 6352 6347 6778 729230 1234 PMC7904922__F4 Photoreceptor metabolic reprogramming: current understanding and therapeutic implications 5728 7248 3091 51548 PMC7905841__F1 Ceramides in Metabolism: Key Lipotoxic Players 2531 253782 29956 204219 10715 79603 91012 7357 427 PMC7910522__F3 Retinoids in the visual cycle: role of the retinal G protein-coupled receptor 9227 50700 6121 6120 5959 PMC7911348__F1 TOR Signaling Pathway in Cardiac Aging and Heart Failure 9776 8408 64798 1977 PMC7912342__F4 RLR signaling pathway 7187 8772 3661 3665 PMC7912608__F5 Diversity of NO functioning in cancer 7852 3091 1499 4513 5764 PMC7914934__F2 Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications 10060 2915 2155 2760 3983 8991 10056 3316 640 5536 7465 83879 10397 7555 6717 PMC7920909__F2 SARS-CoV-2 Replication 59272 100187761 213 PMC7923229__F3 TRIM5Alpha-mediated regulation of innate immune signaling and molecular inflammation 7099 135892 7189 23118 257397 10533 8408 PMC7923692__F1 RPTOR BioID2 reveals spatial association between mTORC1 and FAs 2475 2021 57521 4609 55187 5293 7248 1452 8774 65979 28964 30849 10670 322 8649 64121 22930 55125 7249 5291 1979 5290 57530 27436 9755 84335 9820 399687 253260 2120 5562 84433 6198 64798 6396 64223 58528 9675 81929 1978 79109 3667 79834 823 64759 7145 10456 1785 8994 50807 28956 3987 6251 3636 55742 5829 5515 6009 55740 8874 7094 10006 5566 8665 4026 10109 6194 3337 1977 800 6520 231 8878 526 309 9588 387 2885 6647 161 1175 2773 51719 10312 127829 2887 55004 55737 3482 3551 1601 5159 6714 25959 8673 4905 301 4067 6249 54106 8773 3916 2932 1975 PMC7924042__F6 Molecular mechanism of catalpol in diabetic nephropathy 3479 3630 1610 581 2308 596 5163 5164 5728 1958 7942 836 7056 5292 7412 7018 1019 4313 6401 PMC7925880__F6 LREE regulates bile acid metabolism through intestinal flora 2264 3172 3949 PMC7936035__F7 Not Frozen in the Ice: Large and Dynamic Rearrangements in the Mitochondrial Genomes of the Antarctic Fish 4512 4513 4514 4508 4509 PMC7936166__F7 Relationship between AMPK signaling pathway and lipid metabolism in laying hen hepatocytes 3172 5465 355 PMC7936909__F7 Most correlated MAPK signaling pathway enriched in KEGG mapper 2316 412 100187907 1616 PMC7938643__F1 Interplay between the renin-angiotensin-aldosterone system (RAAS) and the bradykinin (BK) system and chymase 5340 59272 1636 PMC7939748__F3 Molecular mechanisms of plant-based foods in the alleviation of AFLD 7099 9817 4615 2308 1571 355 836 581 PMC7949067__F3 Relevant pathways of the unfolded protein response (UPR) 572 7494 83939 581 PMC7952251__F2 Regulatory mechanism of aromatase and '2-cell, 2-gonadotropin hypothesis' 2492 3479 3480 4087 1051 PMC7983894__F4 Oxidative stress leads to multiple death modalities through various pathways in melanocyte 999 9817 7226 23410 3146 8737 114548 142 847 22926 11035 834 9131 79792 4282 197259 PMC7985092__F1 Schematic diagram of the insulin-like growth factor (IGF) signal transduction and main downstream effects 3481 3479 3630 3482 3480 3643 3667 8660 2885 126669 5728 4193 5163 64798 572 7249 7248 6009 PMC7985092__F2 Several proteins in the IGF signaling pathway such as IGF1, IGF2, IGF-1R, and IGFBPs are regulated by miRNAs 407029 3484 3479 3481 3486 3643 2885 8471 3667 8660 5163 1999 860 572 2475 2002 PMC7988095__F1 Intestinal stem cell compartment and molecular cascades related to AhR signaling 8549 1950 55366 2885 847 324 2475 3280 1956 PMC7996029__F2 Therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma 2475 6010 383 PMC7997471__F5 Proposed mechanism is depicting the effect of IMP inhibiting inflammatory effects 929 3929 7099 4615 3717 3716 9817 6774 6772 6647 6648 847 PMC8000702__F4 C-Peptide as a Therapy for Type 1 Diabetes Mellitus 2876 177 3553 7450 PMC8002044__F4 Potential network of signaling pathways contributing to the chicken lipid metabolism 1718 4047 50814 6307 9023 6319 9370 4023 948 63924 PMC8008708__F2 Scheme depicting the biogenesis of different classes of EVs 11021 387 1956 382 PMC8010885__F6 Cholesterol associated changes in cancer cells and available therapeutic targets 3949 9619 29881 19 PMC8027215__F4 Key genes and metabolic pathways in Lokiarchaeota 65057 3033 2645 2821 2597 5447 35 PMC8027222__F6 Mating type specific transcriptomic response to sex inducing pheromone in the pennate diatom Seminavis robusta 991 472 4361 5888 2638 79629 4602 120356740 100653366 PMC8038143__F5 Link between chemoresistance and MMP-7 shedding of Fas ligand 355 8772 545 472 581 PMC8039963__F7 Genetic and molecular signal dynamics that ZEN mainly affected during PF assembly 7454 10413 7003 4089 8312 54361 2535 3397 8463 PMC8054134__F2 Sources of proline in RPE 65263 29920 4942 54716 PMC8062588__F2 Cancer stem cells and strategies for targeted drug delivery 79923 4609 4170 572 4899 3553 581 9429 6657 22926 7494 468 10111 5888 2146 6935 648 999 3845 472 672 993 4072 928 967 7251 PMC8064323__F10 Gene clusters annotated to drug addiction pathways in HIV+ prefrontal cortex and the effect of Meth use 4988 2895 157 2906 3763 2893 2565 773 113 114 2901 196883 2891 2892 2897 774 9568 1603 2899 115 2894 2890 111 112 2566 2564 116443 2904 2898 2905 108 1137 2557 776 109 2563 107 2562 1141 777 5153 27115 775 5136 2560 778 2567 441509 5141 5137 779 5143 7054 90993 84867 6748 6571 148327 3201 10399 810 4129 50632 11004 7804 1742 5649 1812 817 2354 8831 1600 2902 816 815 2912 5295 116444 3356 2900 5053 154 121278 7166 5528 821 1312 51510 4128 2911 2550 2555 2556 3000 27065 PMC8066579__F4 RLR, TLR and JAK-STAT signalling pathways and interference of signalling pathways by structural and non-structural proteins of coronaviruses 7297 57506 6774 6772 6773 51284 7098 80896 7187 7189 4615 10379 10010 3558 PMC8067389__F2 HCMV regulates the canonical Wnt/Beta-catenin signaling pathway 999 1499 324 PMC8067389__F3 HCMV dysregulates the Notch signaling pathway 3714 182 6774 3280 388585 4851 6657 PMC8070608__F2 Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy 5340 7040 7046 5900 2475 4087 4089 5371 2303 5914 4088 PMC8071059__F2 Priming effects of stress on NLRP3 inflammasome in microglia 114548 3146 3553 3606 3603 6347 6351 7124 PMC8074527__F1 Mevalonate pathway involvement in viral mechanisms 619501 3652 2224 388 387 PMC8074531__F1 Simplified model of insulin-stimulated translocation of the GLUT4 glucose transporter in skeletal muscle 3667 5163 8773 5879 5058 6844 PMC8081860__F4 Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It? 7097 4615 27040 3932 2475 8239 55611 916 923 7535 PMC8082500__F7 KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGFB Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs 4089 4087 4088 4091 4092 84913 255877 9314 2034 3491 1958 8510 3791 PMC8082500__F8 KLF4, a Key Regulator of a Transitive Triplet, Acts on the TGFB Signaling Pathway and Contributes to High-Altitude Adaptation of Tibetan Pigs 4091 4092 84913 255877 9314 3491 1958 3791 2034 8510 PMC8085542__F1 Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH 2695 2696 2691 2692 2642 3949 7068 2690 5465 2264 1581 3479 2932 9965 26291 PMC8088470__F3 Role and mechanisms of polycomb repressive complex 2 on the regulation of osteogenic and neurogenic differentiation of stem cells 7475 80326 2273 3381 4599 860 121340 7704 983 2146 9242 7474 1499 3394 PMC8093597__F2 Immunological and physiopathological approach of COVID-19 in pregnancy 920 324 6402 7113 59272 PMC8102909__F7 Disruption of the cholinergic anti-inflammatory response by R5-tropic HIV-1 protein gp120JRFL 920 7852 1234 1958 3606 23440 PMC8105667__F5 Transcriptome analysis identifies signaling pathways related to meat quality in broiler chickens – the extracellular matrix (ECM) receptor interaction signaling pathway 1101 7450 960 948 961 PMC8106556__F1 Targeting the alternative bile acid synthetic pathway for metabolic diseases 9965 1581 1582 2264 8213 1593 9420 PMC8113272__F2 Genomic network analysis showing the central role of genes related with cell cycle pathway 6804 5443 4904 3456 8544 7067 6608 4040 2150 2149 63923 2932 9112 1501 1457 102 4172 4255 1487 57167 7078 6125 960 545 1788 4869 10645 815 1612 4193 5594 5566 3551 4692 6598 8678 8900 6910 171023 595 1019 55193 861 6662 6926 7291 6257 4609 6256 6935 7157 6615 7020 7490 5914 51341 5915 9839 PMC8114706__F7 Aging signal of C 7248 7249 23411 10013 6009 84219 4609 1977 1975 27250 29904 1938 PMC8115730__F2 Mechanisms controlling pancreatic islet cell function in insulin secretion 47 5091 2936 23152 3417 29843 3418 PMC8117216__F1 Repositioning of Antiparasitic Drugs for Tumor Treatment 5058 79923 6657 581 2475 22983 100133941 960 PMC8120713__F4 Functional conservation in genes and pathways linking ageing and immunity 1956 3570 9053 657 658 4090 4086 60 130399 91 54498 PMC8122033__F4 CGAMP transport in the tumor microenvironment 3661 115004 6573 PMC8123313__F1 Leptin Receptor Compound Heterozygosity in Humans and Animal Models 2885 2308 5443 6774 9021 3717 PMC8124173__F3 Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update 9927 581 596 4193 317 627 PMC8126649__F1 Biological Characteristics of Umbilical Cord Mesenchymal Stem Cells and Its Therapeutic Potential for Hematological Disorders 1021 1019 355 PMC8127222__F2 Emerging role of the KCTD proteins in cancer 8452 84280 222658 115207 2932 1499 284252 324 83892 7126 4851 PMC8133800__F1 Decorin as a possible strategy for the amelioration of COVID-19 4089 4087 4088 PMC8134874__F9 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells 6010 26524 9113 9344 51347 57551 4485 60485 PMC8136122__F2 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) 51548 4087 4089 3146 4092 50507 6010 7048 9759 9353 8482 11167 468 400550 PMC8136775__F1 Untangling the crosstalk between BRCA1 and R-loops during DNA repair 7518 5888 9156 1763 641 79728 675 5893 142 PMC8139249__F1 Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment? 4086 4488 3199 6657 PMC8140599__F3 Interaction network of selected proteins with changes in their abundance in the liver of rats exposed to distress and piracetam 7431 998 27429 9447 143471 4513 677663 6647 23031 5548 2821 5887 23139 821 10165 6396 10130 1376 56886 23193 9415 161 PMC8145797__F1 Host Factors That Control Mosquito-Borne Viral Infections in Humans and Their Vector 27161 4615 23118 1805 8772 PMC8146072__F10 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation 26227 5723 6472 6470 4524 2731 1719 635 4548 468 3091 3845 10797 PMC8146072__F13 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation 7124 836 840 637 572 581 PMC8151225__F9 3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis 999 1000 619501 581 PMC8154153__F6 Compartmentalized Proteomic Profiling Outlines the Crucial Role of the Classical Secretory Pathway during Recombinant Protein Production in Chinese Hamster Ovary Cells 6731 55014 7110 23256 377 22820 55690 10981 100885774 7542 23259 PMC8160449__F1 Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection 60673 9776 8408 9706 22863 4077 9474 9140 10533 64422 PMC8185231__F1 Vitamin D: Possible Therapeutic Roles in Hepatocellular Carcinoma 6774 92140 174 3066 10628 494324 PMC8185338__F1 Autophagy as a Target for Drug Development Of Skin Infection Caused by Mycobacteria 7421 3920 3916 2475 8408 9776 9706 10533 64422 22863 PMC8188681__F1 Review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma 238 1956 2260 2885 6654 PMC8190181__F2 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer 3169 7043 64388 4089 4093 4090 4086 4091 4092 4838 4087 4088 2191 4318 4313 1789 3419 857 6774 7852 6387 6010 PMC8191844__F1 Immunometabolism: Towards a Better Understanding the Mechanism of Parasitic Infection and Immunity 383 5728 847 6395 PMC8197124__F2 Crossroads between Host Copper Metabolism and Influenza Infection 540 538 475 9973 5250 10063 PMC8199608__F1 Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor 100187761 387 998 1020 960 PMC8204192__F4 Genome Analysis of a Verrucomicrobial Endosymbiont With a Tiny Genome Discovered in an Antarctic Lake 2242 4553 95 729 2582 7083 727 PMC8212477__F4 Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (2): impacts of post-partum negative energy balance on stromal, glandular and luminal epithelial cells 9073 137075 4629 79784 3706 5024 1365 5350 4638 150084 5332 3709 291 3993 5590 27134 2065 6263 57530 816 114 5733 64135 3716 2902 6869 5737 9021 103 2353 6772 6347 3726 3356 1131 5610 4599 3460 7124 3665 PMC8213017__F1 Modulation of Ferroptosis and Its Role in Central Nervous System Diseases 10162 2182 100 23657 6520 2879 8031 7018 3652 PMC8213345__F3 Interplay of Forces and the Immune Response for Functional Tendon Regeneration 1080 1499 64102 1277 PMC8215697__F1 Developing Clostridia as Cell Factories for Short- and Medium-Chain Ester Production 3045 100187828 49 PMC8216764__F1 Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity 8440 80895 3982 5728 7099 6714 5163 253260 3611 2932 7124 PMC8218521__F1 Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy 941 4582 930 51083 942 PMC8218521__F2 Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy 130589 6523 51083 2530 2592 8813 54344 8818 3098 3099 2645 4245 2582 79868 5236 7360 7358 4124 2821 7355 55577 2673 4351 10195 442909 4247 5238 5372 2762 29926 29925 85019 84912 6762 6675 7264 23443 197258 10020 4249 6302 10559 140838 55907 PMC8219171__F5 An Examination of the Putative Role of Melatonin in Exosome Biogenesis 2932 9140 10533 83734 64422 9474 4218 PMC8222692__F3 Treg: A Promising Immunotherapeutic Target in Oral Diseases 324 90865 6367 1233 6761 4088 50943 2475 940 PMC8224699__F2 Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis 2019 2020 847 PMC8225793__F5 Mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease 4171 8027 1616 4118 4089 1017 10379 4193 7010 4149 9184 699 9126 999 3652 351 PMC8236063__F8 Mechanistic scheme of DNA-methylation-mediated RSPO2 regulating GCs proliferation, apoptosis and E2 secretion 1869 595 2638 340419 1499 55366 1588 PMC8236581__F1 Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation 4040 4041 324 1499 387 PMC8236816__F2 Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models 120892 55737 10890 23400 PMC8250137__F3 COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality 3953 3667 203 3717 6774 PMC8257727__F1 Signal transduction cascades mediating cisplatin-induced apoptosis (for details see in the text) 6908 472 467 468 545 2021 4193 637 581 150365 1017 PMC8257727__F3 Signal transduction cascades mediating taxane-induced cell death 9474 2592 581 5111 PMC8257731__F1 Detailed drawing of the fine molecular mechanisms of lithium on specific cell targets 22926 7494 2932 627 2475 6774 847 3458 7124 PMC8268428__F2 Janus Face of IL-33 Signaling in Tumor Development and Immune Escape 90865 8205 1017 581 6761 3654 4615 7189 51135 59307 374 PMC8268497__F3 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development 4089 2475 387 PMC8269128__F4 Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences 3099 2597 5230 2023 5315 5163 664 596 PMC8274634__F1 Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control 181 6418 23237 5997 2002 PMC8289577__F1 Hair Cell Protection from Ototoxic Drugs 2002 581 637 PMC8293691__F2 Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target 581 4976 55669 51024 23410 2475 54106 114548 7455 115004 PMC8301100__F1 Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease 2932 8452 9978 9817 8454 65018 1728 PMC8301837__F2 Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells 6663 4851 5058 PMC8304079__F1 CAMP in Beta Cell Stimulus–Secretion and Intercellular Coupling 4666 29850 54795 7226 2696 2695 7432 6752 2693 885 259232 55074 PMC8306455__F5 Evasion of the Host Immune Response by Betaherpesviruses 2475 8772 1950 1956 5163 581 115004 29110 7098 7099 7187 596 3661 4615 7189 PMC8306625__F1 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases 124056 10811 7097 114609 4615 3656 7099 5669 51135 7189 50507 50506 PMC8308509__F3 Hypomethylating Chemotherapeutic Agents as Therapy for Myelodysplastic Syndromes and Prevention of Acute Myeloid Leukemia 331 7336 5591 4173 6667 1786 3479 3082 PMC8313570__F1 Regulatory pathways of ferroptosis 5447 2937 2879 2744 PMC8317254__F1 Mitochondrial and Organellar Crosstalk in Parkinson’s Disease 596 120892 55669 9927 PMC8326120__F1 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue 26060 7038 7494 23411 9444 8841 115004 7350 PMC8326120__F3 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue 7038 63976 656 7350 PMC8326283__F6 Liquid–liquid phase separation in human health and diseases 10146 3932 7535 115004 27040 2885 6654 PMC8346997__F2 GPR39 in Neurovascular Homeostasis and Disease 2863 6010 6722 4827 627 PMC8351721__F7 Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer 5702 5705 324 3717 551 847 6010 998 3984 PMC8356007__F10 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research 2194 5465 3725 2475 5743 3643 8231 596 3458 100379199 1445 3606 5328 1956 1950 PMC8356007__F11 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research 2475 3939 5163 6774 7428 53341 226 7037 51083 2597 6651 PMC8363009__F6 Chemical-protein and protein-protein interaction network of cordycepin and unique proteins from DM+COR and shared protein from N+COR and DM+COR in livers on the hepatic metabolism pathway, analyzed by STITCH v 5.0 51422 23180 5571 5563 5562 5564 5565 5465 2475 4775 207 2308 5689 50 5695 5684 5690 5698 4191 5693 5686 5682 5694 4967 PMC8367394__F12 PPAR signaling pathway regulated by high the concentration of ciglitazone 335 4023 5360 7350 7316 5163 364 PMC8393628__F2 Inflammatory Mediators, Macrophages, and Neutrophils in Glioma Maintenance and Progression: Mechanistic Understanding and Potential Therapeutic Applications 3082 5966 108348016 8195 4609 581 5662 2475 5728 7374 100187907 7189 1956 PMC8396359__F4 Duality of Caspases in Cancer, as Told through the Fly 472 6741 545 PMC8396502__F3 Liquid Biopsy for Cancer Cachexia: Focus on Muscle-Derived microRNAs 3479 406991 3480 7528 406989 5225 2475 406958 664 238 PMC8397972__F4 Convergent Functional Genomics Analysis to Identify Biological Regulators Mediating Effects of Creatine Supplementation 3479 4800 6667 2885 2353 57178 4609 4149 2274 2146 23512 5163 2475 200576 5266 130497 10628 10399 PMC8402453__F4 Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development 3661 29110 115004 PMC8408623__F2 Medical gas plasma-stimulated wound healing: Evidence and mechanisms 8452 9978 9817 4841 2936 1728 PMC8412840__F2 TGFB2 in cartilage development and diseases 4087 4088 4089 4092 7078 1280 4090 4086 860 PMC8416576__F5 Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis 6888 4190 4191 5315 7416 598 50 308 3329 3315 3309 1915 10694 23193 5706 10525 5702 PMC8430477__F6 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 1000 3174 6387 7852 2475 144699 999 PMC8431116__F2 MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype 2744 2875 7462 PMC8431385__F3 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts 7018 4780 4790 847 25828 27035 1536 50508 79400 5602 1432 2729 4501 3162 2876 2878 54578 50507 3726 2353 2936 2953 4257 6647 6648 6649 7498 4128 4784 1543 6117 6118 5983 5981 5984 5982 54107 5426 56655 5427 5985 5395 4437 2956 4436 9156 4292 10714 5424 57804 5425 5111 PMC8431527__F1 Hypoxia Pathway Proteins and Their Impact on the Blood Vasculature 8994 7428 5337 864 51147 6774 383 100750247 PMC8434535__F11 Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish 9451 5610 571 4899 2729 1429 440275 1728 7975 7001 6647 847 6648 2936 5052 7295 3418 9973 23410 PMC8438545__F2 Evaluation of the molecular response of corpora lutea to manganese–amino acid complex supplementation in gilts 39 717 3158 2224 7108 50814 3156 4598 4597 4047 10654 10682 1717 51478 6713 1718 PMC8439554__F1 Mechanisms Contributing to MAC Pathogenesis 780 860 5167 368 249 4256 2717 PMC8450340__F8 Qiangjing Tablets Regulate Apoptosis and Oxidative Stress via Keap/Nrf2 Pathway to Improve the Reproductive Function in Asthenospermia Rats 9817 9978 3725 4094 PMC8450769__F10 Albuca Bracteate Polysaccharides Synergistically Enhance the Anti-Tumor Efficacy of 5-Fluorouracil Against Colorectal Cancer by Modulating Beta-Catenin Signaling and Intestinal Flora 1499 595 5111 PMC8452392__F7 Exploring the Molecular Mechanism of Liuwei Dihuang Pills for Treating Diabetic Nephropathy by Combined Network Pharmacology and Molecular Docking 1958 3717 581 5292 1019 183 1362 7018 6401 4313 4089 4087 4088 PMC8452481__F3 The nervous system in pancreatic cancer 7157 6774 2778 142 6098 3956 4792 4318 238 9314 4609 5925 6714 25 1356 960 5979 4804 7150 2475 5159 2064 4916 10188 4915 3320 6240 3717 6241 7184 1956 50807 4316 3326 1000 PMC8453690__F2 Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke 627 581 572 4318 7124 PMC8458393__F8 Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NFKB signaling pathway 2056 2057 367 4615 8205 558 7301 PMC8464934__F2 Glutathione Metabolism in Plants under Stress: Beyond Reactive Oxygen Species Detoxification 2678 79017 914 PMC8466012__F4 Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism 5163 5166 3091 PMC8466696__F3 Comparison of the transcriptome in circulating leukocytes in early lactation between primiparous and multiparous cows provides evidence for age-related changes 92579 55276 83440 3098 5213 130589 230 2597 5230 5223 84532 5105 219 218 5315 3939 PMC8469128__F1 MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling 494333 5045 6667 406979 2022 2006 407047 PMC8469128__F2 MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling 5728 406978 2475 1277 2006 7189 494333 1959 10252 PMC8471880__F2 Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism 6774 10533 114548 PMC8488354__F3 Cholinergic Receptor Modulation as a Target for Preventing Dementia in Parkinson’s Disease 2932 351 1499 PMC8490190__F2 Emerging Nondopaminergic Medications for Parkinson’s Disease: Focusing on A2A Receptor Antagonists and GLP1 Receptor Agonists 2308 2932 2475 PMC8492658__F1 Cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients 4512 4513 5732 80142 7498 7001 5740 5321 5332 7139 6916 PMC8502867__F2 Safe Path at the Fork: Ensuring Replication-Associated DNA Double-Strand Breaks are Repaired by Homologous Recombination 201973 5557 5888 6741 80198 197342 80820 9156 PMC8508234__F9 Therapeutic and Prognostic Values of LSM Family Genes in Breast Cancer 324 472 6651 1537 5901 22974 PMC8510449__F6 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review 2067 6774 3717 1024 7465 572 7077 PMC8510680__F6 SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF-1A 80854 9113 3939 5230 6662 PMC8511326__F4 Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch 2831 51725 29899 2920 3579 51676 7704 51666 10663 92591 7321 401036 5255 142686 136371 10293 1131 1674 4703 1475 5257 5260 84676 89 51806 7111 148 6375 7168 26154 4606 23620 23581 5506 2837 4923 5837 7139 1910 7140 7169 2248 348938 7051 5236 643418 126638 3270 10321 147111 8074 3488 2266 64066 1758 8836 27006 285848 204219 3848 808 PMC8522911__F1 Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies 10454 3661 3665 7098 51284 4615 51311 7096 7097 7099 10333 7100 3654 51135 7189 PMC8523568__F3 Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway 846 10558 90550 54499 23193 2923 821 56886 5878 1213 22931 10273 9218 9217 PMC8533171__F8 Expression Profiles and Prognostic Value of FABPs in Colorectal Adenocarcinomas 1642 9978 51514 595 998 9134 1019 1021 2313 346389 115426 3082 1788 5598 3667 55294 5728 3479 887 388 4282 57403 6642 324 1499 PMC8533503__F2 Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention 7351 10135 7019 PMC8533541__F2 Bioactive Scaffolds Integrated with Liposomal or Extracellular Vesicles for Bone Regeneration 659 1017 983 581 PMC8533955__F2 Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism 3717 3479 3630 PMC8535772__F3 Glutathione in Mediating Abscisic Acid Signaling and Its Regulation of Seed Dormancy and Drought Tolerance 10006 10152 54861 55034 PMC8537973__F9 Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations 468 6158 8667 5595 207 6170 6154 57761 9451 1649 6231 23645 6720 5170 5295 5287 5296 1977 3265 26523 6193 51065 1973 6192 6169 5610 6137 8891 595 6139 1982 6122 6128 3309 6133 59 6135 60 8663 4827 PMC8537973__F10 Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations 468 4313 3725 4791 79718 7423 6667 3718 4899 80854 2784 5911 9969 3280 51422 4320 5287 5296 3265 208 1742 2768 56034 4705 6648 6391 3479 9282 595 2923 4637 2353 387 2022 140805 PMC8541208__F4 Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis 993 9978 10444 6921 6923 PMC8556920__F1 Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment 3479 3091 2475 3480 PMC8566972__F3 Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond 29110 3661 3665 3659 3458 3558 2475 6352 6348 142 PMC8577250__F1 Low-intensity pulsed ultrasound stimulates proliferation of stem/progenitor cells: what we need to know to translate basic science research into clinical applications 2475 1265 5966 595 7099 890 898 891 PMC8583721__F2 Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases 4087 4089 4088 5155 PMC8583788__F2 Disentangling Mitochondria in Alzheimer’s Disease 5465 4899 7019 23411 23410 3416 PMC8585775__F7 Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity 920 3458 84166 811 2923 PMC8592830__F1 Regulatory host factors and interacting viral proteins of the RLR-mediated antiviral signaling pathway 11074 6737 8473 54726 29110 115992 8805 79589 1788 8841 114088 29978 2932 7726 7187 3959 55669 3437 23087 4487 11119 51365 57506 3661 3665 5094 6048 7706 64750 27246 80335 140461 84640 8445 147945 5093 83737 8887 55432 51701 8061 55611 114803 10869 27338 1540 25976 2268 3932 3055 5494 5347 51035 63906 23170 5688 78990 7345 993 55655 5355 57762 PMC8592830__F2 Regulatory host factors and interacting viral proteins of the cGAS-mediated antiviral signaling pathway 1540 55593 7189 84101 27246 267 10868 11274 29886 29800 54904 23326 1445 29110 3659 3329 115004 3661 3665 8975 23650 6048 10616 7726 5300 220213 9111 5167 25862 27005 1655 9759 10410 10155 5770 5771 5494 79065 79671 59343 27161 54606 4485 468 PMC8599992__F10 Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability 128710 3516 84464 8554 182 7015 546 1616 7018 PMC8600858__F4 Transcriptome provides potential insights into how calcium affects the formation of stone cell in Pyrus 847 790 1312 2077 PMC8601819__F3 Naringenin: A Promising Therapeutic Agent against Organ Fibrosis 7124 3606 1499 4087 4088 4089 6010 PMC8602415__F6 Transcriptome analysis reveals that long noncoding RNAs contribute to developmental differences between medium-sized ovarian follicles of Meishan and Duroc sows 8708 353274 56943 219854 2778 240 284613 943 1543 1588 1847 57799 55714 5577 492 55225 7044 51330 374 2260 3681 56675 6696 57633 387923 50506 5885 83714 56833 5069 949 165631 57761 27299 1413 4354 27197 PMC8610843__F3 Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications 3383 1499 7124 6387 7422 6714 3146 7099 59272 114548 3466 PMC8613465__F3 Signaling pathways and intervention therapies in sepsis 7035 10365 7018 2057 324 PMC8615223__F1 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights 7099 4615 3654 51135 7189 940 4512 7097 2932 2475 3565 1437 9817 1728 PMC8615223__F3 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights 2885 1956 4513 3667 5728 5163 4193 572 7249 7248 6009 2475 596 3091 581 317 355 8772 983 1017 1021 1019 PMC8617551__F2 Antagonism of interferon signalling by SARS-CoV-2 and related coronaviruses 1386 3725 5548 7706 3661 57506 3665 29110 7189 3454 3455 3716 6772 7297 6041 PMC8617980__F2 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? 79923 367 84890 PMC8618899__SF1 Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD 9517 1674 6611 56624 79603 56848 572 5728 2931 2932 7249 7248 2475 PMC8620413__F4 Lipid signaling in cancer 1956 79888 207 7248 2475 2194 47 5163 5728 2171 355 8694 2181 948 PMC8624719__F2 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes 4615 23118 8772 PMC8631411__F1 Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease 8772 8717 7186 717 9140 55626 7405 PMC8635864__F1 To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis 650 4091 4089 4090 4086 1277 860 249 121340 632 4092 PMC8635864__F3 To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis 4040 4041 89780 324 1499 650 860 4090 4086 249 121340 632 PMC8650380__F2 Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications 4317 7099 4615 22861 PMC8650509__F1 Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease 6648 847 5879 6622 65018 PMC8650799__F3 Metabolic alterations reinforce pro- and anti-inflammatory macrophage phenotypes 3553 3458 383 PMC8657568__F1 Plant Dehydrins: Expression, Regulatory Networks, and Protective Roles in Plants Challenged by Abiotic Stress 10006 5597 23379 PMC8662989__F1 Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction 2645 51660 25874 3795 229 PMC8669377__F2 Targeting the “sweet spot” in septic shock – A perspective on the endothelial glycocalyx regulating proteins Heparanase-1 and -2 929 1003 627 7035 3244 PMC8678454__F7 Global Profiling of N-Glycoproteins and N-Glycans in the Diatom Phaeodactylum tricornutum 79087 3630 7054 PMC8684386__F3 Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses 23118 10454 4088 27040 467 6667 2638 108348016 108348018 23586 7939 10664 PMC8687625__F9 Detecting Critical Functional Ingredients Group and Mechanism of Xuebijing Injection in Treating Sepsis 7099 7124 4281 613 929 5879 6850 6886 572 780904 2444 472 4284 100 7412 PMC8688140__F1 Mechanisms of action of ivermectin against SARS-CoV-2—an extensive review 3836 5340 6774 PMC8694249__F1 Phosphatases of regenerating liver are key regulators of metabolism in cancer cells – role of Serine/Glycine metabolism 5617 29968 26227 5723 2731 5728 5163 PMC8698532__F2 Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic Molecules 114548 7503 283131 7099 10252 8168 10984 PMC8699227__F8 Cell Cycle Progression by Growth Factor-Induced Cell Signaling 5728 5163 572 PMC8700241__F2 Metabolic Reprogramming of Liver Fibrosis 3091 3099 5209 5214 5165 80315 5105 2203 PMC8706767__F2 NF‐KB signaling in inflammation and cancer 10892 8915 7189 23118 257397 1540 4615 3654 51135 8717 7186 5971 56957 7187 29110 PMC8709003__F3 Inflammatory Effects of Bothrops Phospholipases A2: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation 7097 4615 4512 PMC8710790__F2 Cholesterol‐Associated Steatohepatitis in the Development of NASH 39 4864 29881 335 64241 64240 19 PMC8714903__F2 Impact of Bartonella VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells 637 6774 9564 387 PMC8714965__F5 Compendium of Information on the Lysosome 55207 153129 8408 9776 7249 7248 5163 PMC8716463__F1 DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication 6741 4968 79661 142 7515 4436 4437 2956 5111 545 472 7518 672 675 5888 PMC8717973__F4 Conversion of PanAms into CoA antimetabolites 79717 60490 5471 PMC8718268__F4 Dynamics of Wnt signalling 4040 4041 324 1499 84133 54894 55366 8549 59352 PMC8720003__F9 Study on the Mechanism of Acori Graminei Rhizoma in the Treatment of Alzheimer's Disease Based on Network Pharmacology and Molecular Docking 3630 351 3643 23385 43 8772 3717 841 7249 2475 836 7031 7124 2002 7442 4513 5241 PMC8724243__F1 Progress on the Function and Application of Thymosin B4 7046 4087 4088 581 1499 51176 PMC8739471__F10 Integrated Pharmacogenetics Analysis of the Three Fangjis Decoctions for Treating Arrhythmias Based on Molecular Network Patterns 858 859 613 5266 3270 5350 90550 PMC8741861__F7 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells 2492 156 157 6194 2869 2870 PMC8741861__F10 Follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells 2492 26060 759 PMC8745665__F2 Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration 3643 3667 8660 3481 2308 1499 2932 5163 3482 4074 572 PMC8748960__F4 Training associated alterations in equine respiratory immunity using a multiomics comparative approach 581 3458 8554 4117 7297 10379 3659 PMC8750298__F3 Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications 4041 4040 8434 PMC8750433__F2 Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines 3479 2475 4087 4088 4485 PMC8760138__F3 Chloroplast ROS and stress signaling 4881 4553 2235 4015 PMC8762167__F1 Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells 6657 572 581 1755 6647 1728 PMC8774030__F1 Therapeutic Potential of Naturally Occurring Small Molecules to Target the Wnt/Beta-Catenin Signaling Pathway in Colorectal Cancer 147111 9241 324 55366 8549 59352 8658 4040 4041 PMC8777795__F3 Novel Pathway of Flavonoids Protecting against Inflammatory Bowel Disease: Modulating Enteroendocrine System 1803 3479 885 PMC8787114__F2 Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis 2885 2534 5062 998 6461 6010 6093 9475 6714 1003 PMC8802807__F12 Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary 1956 1950 7039 685 1839 PMC8820459__F1 p38MAPK Signaling Pathway in Osteoarthritis: Pathological and Therapeutic Aspects 4149 22926 2002 1386 PMC8831980__F2 Fibroblast growth factor 8 in cartilage development and disease 2253 5879 1499 2885 2475 2549 324 PMC8834144__F8 Comparative Transcriptomic Profiles of Differentiated Adipocytes Provide Insights into Adipogenesis Mechanisms of Subcutaneous and Intramuscular Fat Tissues in Pigs 593 2246 5211 377677 51363 7059 11226 942 2353 10797 355 847 8527 54205 8837 10769 PMC8834311__F5 Endocrine Fibroblast Growth Factors in Relation to Stress Signaling 9965 1386 26291 8074 PMC8836075__F2 Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases? 6714 196 405 1728 PMC8841848__F3 Evasion of Host Antiviral Innate Immunity by Paramyxovirus Accessory Proteins 3454 3455 3716 7297 6773 6772 10379 7706 PMC8853826__F2 Insulin signal transduction and metabolic responses in peripheral tissues and their control by mirNas 8651 8835 6928 768219 2308 100616379 PMC8870141__F2 Sympathetic Nerves and Innate Immune System in the Spleen: Implications of Impairment in HIV-1 and Relevant Models 7098 5132 7852 1234 3661 PMC8874935__F3 Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome? 998 5879 7535 6010 2621 8239 8651 PMC8875669__F2 Biosynthesis and the Roles of Plant Sterols in Development and Stress Responses 6608 1718 6476 6746 3652 PMC8878972__F7 Zika Virus Infection of Sertoli Cells Alters Protein Expression Involved in Activated Immune and Antiviral Response Pathways, Carbohydrate Metabolism and Cardiovascular Disease 54625 6513 2168 6515 2309 5223 1435 226 2252 2997 5230 4126 960 55856 23516 3037 4067 9945 2170 3576 5315 81579 8898 4938 5359 4060 6482 2799 1280 27230 1634 347 5331 PMC8882121__F6 Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades 5333 3490 1017 6813 84617 5880 302 1969 391 1432 387 5728 8452 2934 7295 57521 1947 1508 5894 7040 5338 5629 5566 226 81 4478 1213 10109 7415 5898 PMC8888875__F2 Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis 4089 4087 4088 7124 1277 1281 9817 4094 324 1499 3458 3553 PMC8894711__F2 Novel Molecular Therapeutics Targeting Signaling Pathway to Control Hepatitis B Viral Infection 1499 6773 115004 595 PMC8897153__F1 Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma 26227 3099 2821 226 2597 5230 5223 2023 2203 619501 2539 5091 3146 22934 7086 3418 PMC8909056__F1 Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity 920 7054 83475 6303 2309 PMC8910147__F1 CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer: Theranostic Perspectives 7852 2919 4283 3627 383 3576 58191 6387 10663 2833 3579 3577 1499 6373 2353 920 643 6374 5132 4282 PMC8910720__F3 Pathogenesis of Cardiac Fibrosis: A Review of Recent Progress 10716 4087 4088 6010 4092 4091 4089 3371 PMC8913803__F7 Signaling pathways and targeted therapy for myocardial infarction 442912 6497 4485 60485 9113 26524 5308 2064 6714 6469 6608 2735 2736 PMC8917804__F3 Cellular and humoral host immune responses to SARS-CoV-2 viral infection 10379 6773 6772 59272 1431 7297 7098 51284 920 4615 3665 57506 3661 PMC8923649__F5 Correlation of SARS-CoV-2 to cancer: Carcinogenic or anticancer? (Review) 367 59272 7113 5728 572 PMC8935981__F8 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches 1499 7054 847 1957 100187761 PMC8935981__F10 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches 672 675 545 472 2099 2100 5111 7508 4436 10111 2177 5888 PMC8945922__F7 Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components 83734 3320 10533 3481 9140 64422 581 90550 PMC8946846__F9 Failure Analysis of TEVG’s II: Late Failure and Entering the Regeneration Pathway 7408 847 3654 4322 7450 PMC8949863__F2 Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity 115004 3661 3665 5052 PMC8959714__F2 Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19 59272 5045 7113 PMC8960222__F2 Rewiring mitochondrial metabolism to counteract exhaustion of CAR-T cells 4609 7019 4899 9760 PMC8967065__F3 PCP signaling in kidney development 79633 7481 8642 54798 54361 5754 7474 2195 57216 9620 5979 2668 4919 4920 51057 8322 8325 23607 81839 8323 7976 PMC8967572__F4 Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer 57530 9817 545 472 PMC8971815__F2 Intestinal Fibrosis in Inflammatory Bowel Disease and the Prospects of Mesenchymal Stem Cell Therapy 1499 207 2932 4092 208 4088 4087 4089 PMC8972902__F4 Clinical and translational values of spatial transcriptomics 7305 4023 567 348 8542 768 30001 7033 7031 7032 1080 10321 4852 54209 203228 6696 6490 100423062 2512 PMC8988245__F2 Endoplasmic Reticulum Stress of Gut Enterocyte and Intestinal Diseases 468 9927 7494 PMC8992440__F1 Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review 441376 5243 324 54658 1244 9429 7150 PMC8992488__F2 Glioblastoma chemoresistance: roles of the mitochondrial melatonergic pathway 145258 196 15 1545 6648 406 5132 PMC8997791__F2 Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases 9474 10533 2475 9817 PMC8999811__F1 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs 4015 8454 81857 4609 PMC9000186__F1 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury 8877 56848 64781 PMC9009225__F5 Qinggan Huoxue Recipe Alleviates Alcoholic Liver Injury by Suppressing Endoplasmic Reticulum Stress Through LXR-LPCAT3 10162 22926 466 83939 7494 PMC9009237__F5 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications 9817 2548 847 PMC9011134__F7 Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway 9474 5058 596 581 PMC9016027__F1 Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration 10371 8829 4099 387 4974 84894 PMC9019277__F1 Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer 3091 5308 6608 5727 5243 4089 PMC9019350__F1 Sea Cucumber Compounds Targeting NFKB in Cancer Treatment 6395 4318 7412 7852 3576 1956 596 4055 896 595 894 PMC9035692__F3 Clinical Potential of Dental Pulp Stem Cells in Pulp Regeneration: Current Endodontic Progress and Future Perspectives 355 3135 3082 PMC9036252__F1 Two Modulators of Skeletal Development: BMPs and Proteoglycans 659 92 93 4090 4086 860 10454 PMC9049047__F1 All roads lead to DSBs 672 5888 675 PMC9049047__F5 All roads lead to Gaps 202309 672 5888 675 PMC9061815__F5 scATAC-seq analysis and heterogeneity of regulation between MGE and LGE 5358 5454 10215 1869 6925 4094 10485 6664 170302 4208 1746 221833 4781 7026 7025 26468 7080 9126 6657 1745 1749 84107 6659 6750 9168 619279 114908 2104 5087 53335 71 128553 3670 79776 388 4212 388585 390 3727 5455 2305 3725 6651 51222 4149 4899 9369 57127 84858 431707 7903 55704 4209 10643 9586 3400 4150 429 51427 PMC9061914__F6 Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene- and protein expression profiles 1499 1513 1634 1300 7057 7040 7046 308 6696 9377 3091 7423 3939 PMC9083176__F1 Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury 5163 7249 7248 6009 5728 6647 84232 PMC9084887__F2 Advances in the Structural and Physiological Functions of SHARPIN 958 7186 81858 100187907 4615 PMC9092887__F10 miR-23b-3p rescues cognition in Alzheimer’s disease by reducing tau phosphorylation and apoptosis via GSK-3B signaling pathways 23621 102 581 2932 PMC9099445__F1 DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders 2521 142 7515 5423 3980 79661 545 472 847 5888 9156 641 10432 PMC9111035__F4 Critical evaluation of risk to reward ratio of quercetin supplementation for COVID‐19 and associated comorbid conditions 19 7350 7038 PMC9117991__F5 Lactate and the Lactate Dehydrogenase in Inflammatory Diseases and Major Risk Factors in COVID-19 Patients 3948 3939 960 PMC9137176__F7 Granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin 3973 10413 374 1956 2638 PMC9138354__F1 Synergistic Cooperation between TGFB and Hypoxia in Cancer and Fibrosis 4089 4092 26060 55198 7189 5663 4318 4313 3569 6010 PMC9140735__F8 STIM1–Orai1 Interaction Exacerbates LPS-Induced Inflammation and Endoplasmic Reticulum Stress in Bovine Hepatocytes through Store-Operated Calcium Entry 84876 6786 22926 PMC9141180__F2 Soyasapogenol C from Fermented Soybean (Glycine Max) Acting as a Novel AMPK/PPARA Dual Activator Ameliorates Hepatic Steatosis: A Novel SANDA Methodology 351 2159 3417 1268 9212 5587 5241 25 1394 2053 5724 993 3619 3702 1901 6850 5209 7272 55851 5664 1813 5770 7150 6790 10846 1147 3551 2912 100187761 7851 2149 1269 1017 23385 29881 43 6097 6462 5791 5426 52 10062 367 3156 6532 595 590 2339 2638 5771 5836 1956 3717 2167 2166 1432 2170 415116 5467 4193 7421 56848 4986 7015 2539 759 5243 1514 479 6319 7298 8877 847 762 673 10000 1559 2342 5583 1543 5465 PMC9145045__F2 Type I and Type II Interferon Antagonism Strategies Used by Paramyxoviridae: Previous and New Discoveries, in Comparison 7706 29110 23586 3661 57506 7098 51284 54106 7187 51311 3665 7124 4615 51135 PMC9146201__F1 Targeting Energy Metabolism in Cancer Treatment 3099 2597 5230 2026 PMC9197245__F7 Strontium Regulates the Proliferation and Differentiation of Isolated Primary Bovine Chondrocytes via the TGFB/SMAD Pathway 7040 4088 4089 4086 4090 4093 860 1280 176 1300 6696 249 PMC9199543__F3 Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective 627 2475 3065 3066 22933 5742 4512 PMC9202500__F5 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses 7494 468 22926 847 637 581 7416 PMC9207015__F1 Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population 7189 4615 257397 PMC9208314__F1 Translation initiation pathway 4553 1998 1999 2001 1983 1997 10209 1975 9669 PMC9209463__F3 Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases 2194 847 6774 22937 3717 84433 387 7422 6010 5879 1839 1956 5170 1003 PMC9234286__F2 Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis 387 6093 6722 PMC9235413__F1 Canonical and noncanonical Wnt signaling pathways 2932 1499 324 3725 1386 4040 4041 6010 6259 4920 998 PMC9235413__F3 Crosstalk between Wnt and other major signaling pathways in uterine fibrosis 2475 1499 595 4040 4041 3479 8650 PMC9237441__F5 Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities 558 2621 572 596 317 6774 581 PMC9239699__F3 ERH Interacts With EIF2A and Regulates the EIF2A/ATF4/CHOP Pathway in Bladder Cancer Cells 6157 100187761 5725 5094 6175 6159 3034 55696 26097 1509 6191 6203 9349 6160 6134 23435 5901 6130 5687 2091 PMC9240209__F2 Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors 29110 57506 3661 7098 PMC9244704__F10 Integrated Metabolomics and Transcriptome Analyses Unveil Pathways Involved in Sugar Content and Rind Color of Two Sugarcane Varieties 2821 2799 11181 2992 2632 PMC9247256__F6 Alterations of Cardiac Protein Kinases in Cyclic Nucleotide-Dependent Signaling Pathways in Human Ischemic Heart Failure 6188 5837 5213 6204 5214 6156 230 6187 7018 6191 226 PMC9250250__F5 Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method 1845 55970 348 9446 3500 23385 7165 5701 2288 1291 5202 6277 5371 1292 392 6623 960 3939 1293 5236 7124 1727 6804 8050 2200 5093 7001 1191 581 51 220296 2335 759 10382 347733 84617 10574 9588 2162 2670 5869 5577 50865 1994 5520 488 83660 10728 PMC9256747__F2 Molecular mechanisms underlying suicidal NETosis and vital NETosis 847 4513 7097 7099 4353 3579 PMC9261412__F3 Recent Advances on Drug Development and Emerging Therapeutic Agents Through Targeting Cellular Homeostasis for Ageing and Cardiovascular Disease 7186 7494 83939 468 22926 PMC9271773__F2 Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy 1499 472 831 7410 10682 7515 PMC9271835__F1 Thiol Modifications in the Extracellular Space—Key Proteins in Inflammation and Viral Infection 3146 2937 7189 4615 57716 PMC9273153__F3 Regulation and Signaling of TGFB Autoinduction 4089 4087 4088 4092 3725 2353 387 2475 1977 PMC9274484__F2 Gut microbiome in gastrointestinal cancer: a friend or foe? 999 672 10392 5728 9462 2475 1499 27035 8313 PMC9277653__F4 Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment 2078 7018 2475 1950 1956 PMC9289477__F1 Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers 324 3932 2534 7535 27040 940 PMC9293537__F5 Pharmacological Approaches to Decelerate Aging: A Promising Path 3667 7248 2882 PMC9294202__F3 Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule 10419 9748 83737 8837 79097 5470 27122 7186 8239 7128 PMC9300056__F3 Plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum 5979 4827 4149 56961 22872 10484 574 581 PMC9301571__F2 Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming 6295 2475 6469 PMC9304715__F5 Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NFKB Pathway 157310 4353 7099 581 PMC9307469__F1 Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients? 3665 59272 3455 5045 7113 3454 50943 PMC9308265__F8 Chronic heat stress promotes liver inflammation in broilers via enhancing NFKB and NLRP3 signaling pathway 7099 114548 3553 PMC9312358__F4 Oxidative Stress in the Pathogenesis of Atherothrombotic Diseases 23410 23411 6647 6648 3280 7412 3383 4851 PMC9317349__F1 Present Status, Challenges, and Prospects of Dihydromyricetin in the Battle against Cancer 4193 581 50507 4088 2475 5728 6774 6667 PMC9318484__F2 Natural Products and Their Multitargeted Approach to Treat Solid Cancer 3667 7455 572 6009 5163 7249 7248 2475 5728 2308 1977 PMC9318596__F2 Exploring the Role of Staphylococcus aureus in Inflammatory Diseases 6395 4049 114548 79792 8737 11035 197259 7098 7099 3916 PMC9319447__F4 Identification, Characteristics and Function of Phosphoglucomutase (PGM) in the Agar Biosynthesis and Carbon Flux in the Agarophyte Gracilariopsis lemaneiformis (Rhodophyta) 2717 2821 2592 412 5805 PMC9320269__F4a Analyzing the Systems Biology Effects of COVID-19 mRNA Vaccines to Assess Their Safety and Putative Side Effects 3105 267015 920 3106 1325 PMC9320502__F3 Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions 4094 7189 114548 PMC9322748__F11 Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor 290 570 2876 25825 PMC9336077__F2 Molecular biology and therapeutic potential of Nrf2 in leukemia 9817 8452 9978 4919 571 2932 6500 PMC9340150__F2 Structure, biosynthesis, and biological roles of fetuin-A: A review 3458 3717 50507 PMC9340220__F1 Antioxidants in Human Milk on Bronchopulmonary Dysplasia Prevention and Treatment: A Review 7295 29843 23411 847 1728 PMC9344793__F3 Cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics 64240 64241 3949 39 3931 53369 9619 19 4023 948 10011 38 PMC9354928__F11 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma 369 673 2885 4763 1029 7157 6772 PMC9368916__F3 Comparative Transcriptome Analysis Reveals Coordinated Transcriptional Regulation of Central and Secondary Metabolism in the Trichomes of Cannabis Cultivars 4015 3652 4597 2619 PMC9388649__F7 TMEM16E affecting bone metabolism through intracellular Ca2+ signal transmission 1499 5741 4772 PMC9393179__F3 Favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms 3553 3458 3654 PMC9397555__F2 Involvement of phosphatidylserine receptors in the skeletal muscle regeneration: therapeutic implications 8578 4240 948 6714 2621 558 387 PMC9398379__F2 Whiff of the future: functions of phenylalanine‐derived aroma compounds and advances in their industrial production 790 8213 55107 PMC9403138__F3 Microbiota-derived short-chain fatty acids: Implications for cardiovascular and metabolic disease 1230 729230 3577 6347 1524 114548 PMC9404924__F2 Potential Implications of Hydrogen Sulfide in Aging and Age-Related Diseases through the Lens of Mitohormesis 140821 1821 55669 65018 PMC9405286__F1 Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review 1499 1019 595 4087 4088 999 1000 7037 2512 472 581 1956 2475 64422 6774 79923 6657 7099 4615 PMC9405677__F18 Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease 356 2912 3480 3984 2932 6844 1742 112755 3162 836 6657 9568 3725 9759 5864 207 6860 5179 351 63908 2147 7124 4035 2354 2557 2332 5578 2353 6854 815 8503 793 6934 841 23237 5368 5743 6538 2915 348 1390 1961 2892 429 1385 6529 794 8837 2049 1009 5173 10000 814 4297 PMC9406959__F7 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma 60485 4485 9113 26524 7474 81029 PMC9407090__F1 Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure 3689 3696 3676 3383 50848 941 920 6403 6401 6402 29126 6404 8174 PMC9407613__F2 New Insights into the Functions of MicroRNAs in Cardiac Fibrosis: From Mechanisms to Therapeutic Strategies 5045 51582 693218 64750 6667 100033819 5478 PMC9414909__F4 Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy 581 4025 847 PMC9417543__F1 Microbiota and COVID-19: Long-term and complex influencing factors 383 50943 7113 59272 3569 2475 PMC9425441__F7 Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V 11093 7450 5091 PMC9426234__F1 HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways 3098 3099 3101 80201 PMC9433211__F2 Ferroptosis and Its Relationships with Other Types of Programmed Cell Death: Insights for Potential Therapeutic Benefits in Traumatic Brain Injury 6955 1540 6476 PMC9434839__F3 Oxidative stress in ovarian aging: a review 9817 572 1728 2475 847 PMC9445553__F6 Immune responses to different Uropathogens call individual interventions for bladder infection 6364 2920 6347 84659 1956 3045 100187828 PMC9453876__F14 Honokiol improves depression-like behaviors in rats by HIF-1Alpha- VEGF signaling pathway activation 2056 2475 5662 PMC9454615__F3 Impact of COVID-19 on populations living at high altitude: Role of hypoxia-inducible factors (HIFs) signaling pathway in SARS-CoV-2 infection and replication 4142 59272 7113 PMC9456412__F2 Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder 4512 4513 5228 PMC9465090__F1 System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy 467 1956 3934 468 6241 23657 6520 2937 4015 2879 3652 54802 6667 PMC9471313__F3 Excessive intake of sugar: An accomplice of inflammation 7099 3553 7124 3934 4513 PMC9476852__F6 Chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms 1956 3273 3082 558 5447 613 6850 930 8480 5728 6476 4763 951 126669 6774 3976 7248 7249 572 6256 4193 672 5934 1977 PMC9478949__F10 Alternative splicing of Arabidopsis G6PD5 recruits NADPH-producing OPPP reactions to the endoplasmic reticulum 84706 2539 355 545 PMC9482317__F3 TGFB signaling in the tumor metabolic microenvironment and targeted therapies 7049 7086 2539 7040 2194 4087 948 50814 6935 6721 8140 PMC9496564__F2 Co-Stimulatory Receptor Signaling in CAR-T Cells 940 5163 941 942 2475 2885 3932 2932 27040 5335 1386 7185 7186 7187 PMC9508608__F1 Methionine restriction - Association with redox homeostasis and implications on aging and diseases 4397 635 875 6611 6723 PMC9516464__F2 Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease 581 4283 9242 383 64806 7098 PMC9520111__F2 TNFIFN-induced necroptosis 7124 7186 8717 8772 836 840 197259 11035 253868 3454 81030 PMC9531660__F3 Species-specific transcriptomic changes upon respiratory syncytial virus infection in cotton rats 5340 3458 7099 57762 355 7098 51284 834 6041 6035 8772 637 7706 9021 581 79671 7187 842 3661 3665 3553 3606 896 836 4928 1021 1019 3569 103 5371 10482 PMC9534575__F2 Quaternary ammonium compounds in hypersensitivity reactions 85480 3565 920 7054 PMC9535022__F4 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials 54904 6657 53335 5931 5928 23512 2146 6418 4200 4149 10873 55294 2475 PMC9538505__F11 TRPV1 channel in spermatozoa is a molecular target for ROS-mediated sperm dysfunction and differentially expressed in both natural and ART pregnancy failure 213 7514 301 7415 348 7019 6732 2810 483 567 6390 813 997 1191 1642 2023 5315 2597 2923 9518 2805 4353 3860 440574 4282 PMC9562180__F2 Macrophages, Chronic Inflammation, and Insulin Resistance 7097 7099 4615 8717 7186 3667 207 3569 3570 9021 PMC9563854__F3 Natural antisense transcripts as drug targets 64750 9097 4193 PMC9577232__F6 Targeting the cannabinoid system to counteract the deleterious effects of stress in Alzheimer’s disease 1499 2932 23621 PMC9577372__F2 Transforming growth factorB in tumour development 7049 4087 4088 7046 4089 4092 998 387 2303 9839 7291 6935 8091 3169 3170 2002 1386 2885 7189 23118 PMC9581181__F2 Ion channels as a therapeutic target for renal fibrosis 7225 2475 847 84876 4088 4087 114548 54822 7442 PMC9582513__F3 DNA damage checkpoint execution and the rules of its disengagement 1763 641 9156 472 9656 84126 11073 545 675 672 PMC9589221__F6 Melatonin signalling in Schwann cells during neuroregeneration 5163 6469 2735 627 2668 PMC9598036__F3 Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics 84894 54209 4023 348 53369 383 102 10313 23385 2534 388585 2475 PMC9598036__F4 Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics 627 84894 4035 348 2475 4851 383 54209 19 2621 1436 23621 3084 388585 2534 3688 PMC9598565__F3 Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease 5074 4842 50632 84152 814 1387 170954 1020 64919 6418 PMC9602982__F2 Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System 22937 3156 1717 PMC9606746__F1 Terpenoid natural products exert neuroprotection via the PI3K/Akt pathway 581 4513 2932 1499 5728 2475 PMC9612132__F2 Heparin and Heparin-Based Drug Delivery Systems: Pleiotropic Molecular Effects at Multiple Drug Resistance of Osteosarcoma and Immune Cells 3667 5163 3717 6774 6714 4851 3091 1499 89845 4363 5243 9429 PMC9614744__F7 Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D 1950 367 685 126669 2885 867 572 3725 4609 PMC9614744__F8 Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D 355 929 2885 51083 7189 7186 1616 1610 23118 51295 40 57136 4282 51701 2002 4150 4149 PMC9996228__F2 Genetic control of meiosis surveillance mechanisms in mammals 23626 472 545 581 285498 PMC10031108__F9 Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway 581 317 8452 9817 PMC10033682__F4 Ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway 217 4323 196 23621 23269 5792 873 10055 132 1813 9429 2932 1956 1815 5292 3577 7498 596 4313 4170 4312 2099 2322 2931 4318 50507 6462 983 1233 PMC10035551__F1 Regulation of PD-1 and PD-L1 expression in sepsis 324 942 941 940 7535 PMC10037588__F6 Reassessing the Abundance of miRNAs in the Human Pancreas and Rodent Cell Lines and Its Implication 3630 3643 867 2885 7249 6009 2002 2308 572 1977 25886 355 PMC1327675__F3 Interactive map (pathway) of 46 genes/proteins created in PathwayAssist® from the list of transcripts up-regulated in the testes of ABP-transgenic mice 4133 4311 847 2114 4802 695 1080 4908 4609 1958 2668 5241 1535 790 6462 467 960 4069 7276 6590 3569 5653 4624 2 5189 1201 4617 PMC1383482__F1 Tumor Necrosis Factor by Microbial Pathogens 7124 8717 8772 637 581 PMC1526619__F1 Wnt/Beta-catenin signaling pathway 7471 2932 324 1499 PMC1622889__F1 Anti-apoptosis of families of HSPs 596 666 581 PMC1751079__F1 Inhibitory signals of the Toll-like receptor (TLR)4-induced MyD88-dependent signaling pathway 929 7099 6761 59307 4615 54472 3654 3656 51135 7189 9618 1796 9021 5901 6667 7124 PMC1839891__F10 In this model, the tumor growth process is replaced with the cell cycle model from figure 7 6608 2736 983 595 324 2932 PMC185249__F3 Sprouty is a rapidly inducible negative regulator of fibroblast growth factor (FGF) pathway signaling 2885 10818 10253 PMC185249__F4 Signal transduction in the Transforming Growth Factor B(TGFB) family pathway is finely regulated at many levels 7124 1950 6010 6497 4838 PMC1904229__F12 Schematic model of Zfra/WOX1 involvement in TNF signaling 8717 8772 7186 PMC1929113__F6 Upregulation of cyclins and CDKs in melanoma cells 545 472 4089 6502 993 1017 914 9133 PMC2106361__F1 Current model of the Fanconi anemia pathway 55120 2178 91442 57697 641 2175 80233 2187 2188 2189 2176 545 2177 672 5111 56852 PMC2121320__F2 MTA family of coregulators in nuclear receptor biology and pathology 57504 9112 54361 9219 3091 54828 PMC2196458__F7 Fas-signaling pathways in relation to the cytoskeletal networks, the Golgi-sorting compartment, and the surface membrane 1956 1950 2638 637 8772 355 PMC2212359__F5 HToll and TNFR-1 signaling pathways 4615 8717 7186 7189 1386 2002 PMC2246131__F7 Schematic diagram showing the possible effects of the reelin pathway in protection from CM 5649 7436 6714 1600 2932 PMC2266794__F4 Integrative Genome-Wide Expression Analysis Bears Evidence of Estrogen Receptor-Independent Transcription in Heregulin-Stimulated MCF-7 Cells 1610 7959 759 1956 4751 4342 4863 23118 51701 367 PMC2267714__F3 Gene expression changes detected in selected pathways in M group 545 5111 1039 387569 PMC2315691__F1 Complement system and complement regulatory proteins (CRegs) 5648 629 717 1378 727 966 PMC2374711__F5 Proposed model of APL pathogenesis induced by PML-RARA 80205 604 54880 5371 5914 27044 10915 7343 6689 6775 4092 1959 1958 2118 4802 466 4613 2353 6932 86 7391 6777 51176 4605 84159 2308 6095 6256 861 4800 PMC2390572__F10 MCF10A Pathway 2 affected by TFIIS knockdown 25759 5816 2785 22809 2782 37 10988 5338 51141 1241 11009 3638 23645 9748 PMC2394752__F4 Contextual organization of the NFKB positive modulators 6885 10204 6767 7289 23635 3281 7124 7186 8705 5498 23118 26499 10298 6293 329 958 29108 488 5901 8797 6237 8772 7132 10864 10180 4049 114609 59349 10769 64089 7133 7301 51330 3551 8517 37 103 80007 817 6367 81669 1536 1854 1959 89846 9615 10804 2769 2819 56927 80333 84930 8932 6945 10276 4983 5264 58473 79156 10560 56301 9784 7097 7108 8795 8792 8718 8743 6955 58485 10346 10024 10224 9020 9069 PMC2397440__F8 Possible role of AICAR and compound C on the AMPK pathway and on glycolysis in CT-2A and astrocytes under low glucose conditions 7249 2475 1311 PMC2408969__F8 Deciphering the Ubiquitin-Mediated Pathway in Apicomplexan Parasites: A Potential Strategy to Interfere with Parasite Virulence 1637 324 7316 991 6500 4118 9978 8454 PMC2417166__F8 Wnt signaling pathways in INS-1 cells 1950 2932 1499 6934 PMC2424294__F2 Induction and lifetimes of signal transduction proteins (and their mRNAs) at various positions in signal transduction networks 7039 2057 5728 1537 1384 7249 PMC2435278__F2 The Aedes aegypti Toll Pathway Controls Dengue Virus Infection 4615 8772 7275 7054 PMC2480606__F1 An outline of major signaling pathways leading to NFKB activation 8717 4055 7186 4615 7189 23118 10454 8915 10892 472 602 5971 PMC2518924__F9 The CEBPD network 1052 2670 2353 4155 PMC2542903__F6 Proposed EphB2 signaling network 27 10152 23191 9732 8660 6461 2017 4921 7314 8027 4734 9958 PMC2552992__F9 Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease 3066 64422 10533 1874 1958 PMC2564829__F7 Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells 31 545 995 PMC2574638__F8 Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s Disease 351 3603 572 PMC2575612__F4 Inter-individual mRNA expression variances in the mitogen-activated protein kinase (MAPK) signaling pathway in rheumatoid arthritis (RA) compared with normal control (NC) 1610 4351 5447 5891 100187907 8195 PMC2582888__F8 Two parallel pathways are required for Abl-dependent cell detachment 4018 387 1399 6093 1969 PMC2592809__F9 Scheme summarises different intracellular pathways during osteoblast differentiation which include promoting (blue) and inhibiting (red) factors and are mainly mediated by Smad proteins 89780 10097 759 4091 4092 1499 650 860 6497 1749 1747 10682 7939 4488 PMC2630373__F1 Regulation of G1/S transition by growth factor (insulin and IGF-I) signaling in Beta-cells 4087 4088 4089 8660 3667 207 208 4193 2305 894 595 3651 1869 PMC2637651__F3 Transcriptomes in Healthy and Diseased Gingival Tissues 627 4351 4342 2316 1399 412 355 1616 4149 8195 929 23118 51701 1950 PMC2641000__F4 Cell-Autonomous Requirement for Rx Function in the Mammalian Retina and Posterior Pituitary 5015 6657 5080 6496 9355 7546 PMC2649725__F7 Model showing the activation of the JNK pathway upon challenge by UVB 6093 3014 790 PMC2650010__F2 Akt-dependent and independent mechanisms of mTOR regulation in cancer 7248 7249 6009 2475 64223 8491 PMC2655678__F1 ATM activation in response to DNA DSBs 472 4193 993 995 672 9656 10111 4361 2177 1017 PMC2662368__F2 T cell differentiation proceeds along distinct pathways following antigen presentation by DCs 920 3458 6775 2625 196 6778 6774 3586 50943 PMC2667382__F8 Phosphorylation of the Translation Initiation Factor eIF2A Increases BACE1 Levels and Promotes Amyloidogenesis 1998 83939 23621 PMC2668982__F2 CCN1 signaling and crosstalk with TNFA 3491 5879 7186 8717 8772 843 841 637 581 PMC2669301__F1 Tyrosine kinase network regulating mast cell activation 3815 7462 6714 4067 2885 6850 9846 7409 695 3717 6772 PMC2676302__F5 Major trends in mRNA expression at 56 days on experimental diets and summary network analysis among genes 57678 2539 47 31 2194 7069 2167 5467 5562 9663 5468 6319 9415 22937 376497 PMC2676892__F3 Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors 3156 8013 1843 1390 2355 6515 4929 374 9021 5141 PMC2677763__F7a Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways 2353 466 1386 467 847 6647 468 4094 22809 55729 10538 9817 3725 57626 317719 2936 2877 3163 2876 2053 2052 54658 2878 7368 2879 3417 2678 2880 5052 2882 7001 4257 2937 PMC2693384__F2 Regulation of Vascular Permeability by Sphingosine 1-Phosphate 324 5879 5058 790 9815 PMC2695826__F1 Ingenuity pathway analysis identified a network of genes down regulated in response to 60 minutes of ischemia in aged mouse liver 22803 1386 8880 902 PMC2704458__F2 Histone Acetylation in Drug Addiction 10014 1020 2354 PMC2705117__F3 Role of peroxisome-proliferator-activated receptor B/D (PPARB/D) in gastrointestinal tract function and disease 595 324 6256 4513 51129 PMC2714185__F1 Role of ATM in cellular responses 472 4193 993 995 672 9656 10111 4361 2177 1017 PMC2715958__F1 One possible pathway which regulates cell proliferation in response to strain on collagen 6714 5879 208 2932 PMC2721971__F3 EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis† 1950 1956 2885 2549 382 867 5163 PMC2725207__F3 Tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1 5984 5983 5982 5985 PMC2728430__F1 How ERK1/2 Activation Controls Cell Proliferation and Cell Death Is Subcellular Localization the Answer? 2885 2002 2353 PMC2730725__F1 Nm23-H1suppression of tumor metastasis may depend on at least three pathways 11171 6418 3897 PMC2733936__F1 Targeting the ASK1/MKK4/JNK pathway upstream of mitochondrial prodeath signaling 7186 637 572 581 331 PMC2743116__F1 Ras/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) 6654 2885 161742 4763 673 PMC2745643__F1 Beta-catenin signaling and its regulation 324 1499 607 PMC2746238__F2 Induction of autoimmunity by pristane and other naturally-occurring hydrocarbons 729230 7099 51284 7098 54106 51311 4615 29110 PMC2746245__F2 Toll-like receptor (TLR) pathway 4615 54472 7189 3553 7097 7098 7099 7100 51311 51284 PMC2746245__F6 Injury-induced changes in the nociceptive pathway 729230 1234 7852 3603 7442 2833 PMC2749695__F5 Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target 1080 7408 2475 6009 5225 1499 7249 4609 5934 572 4193 PMC2755611__F1 Regulation of aging: does autophagy underlie longevity? 5728 22933 23411 5894 7249 7248 4899 6009 1977 PMC2756316__F5 Proposed model for the interaction between PyVmT and IR or IGF-IR 2885 5335 6714 PMC2756670__F4 The proposed model underlying the potential lithogenic mechanisms of estrogen through the estrogen receptor 1 (ESR1) pathway in the liver 2099 64241 64240 8647 5244 PMC2762102__F5 Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis 54962 545 84126 5429 3014 472 5111 4172 4174 4173 4176 4175 4171 PMC2767105__F2 Intracellular ascorbate (Asc) modulates redox-sensitive signaling pathways in microvascular endothelial cells during sepsis 3458 3717 6772 3659 PMC2768529__F8 Proposed interplay between IL-15 and TNFA signaling in skeletal muscle 790 3601 8772 8717 7186 PMC2768990__F2 BANs of differentially expressed genes in common between cell lines 9965 11010 9388 3428 1601 3872 5349 1719 6876 6641 93664 1836 8503 23635 PMC2768997__F1 Human protein-protein interaction network of aging-associated genes 6908 4791 7341 3065 4790 4609 7157 207 3558 5925 2033 3480 641 5595 1956 5594 5111 472 2237 2099 3717 25 8660 5979 6464 2885 5770 PMC2773416__F6 Diagrammatic representation of intracellular pathways that lead to the production of IL-12p40 and the mechanisms of azithromycin (AZM) to inhibit the expression of IL-12p40 upon the stimulation of LPS/IFNG 7189 4615 6772 3726 PMC2774576__F1 Diagram illustrating the biosynthetic pathway of n-3 and n-6 fatty acids from dietary precursors 9415 3992 95 PMC2782433__F1 COPPER ACTIVATION OF NFKB SIGNALING IN HEPG2 CELLS 285 7057 4879 6364 7436 4082 5031 2887 7414 1326 8878 7273 4790 3164 5971 1263 688 3097 4084 1847 1410 10248 PMC2783859__F3a Identification of Actively Translated mRNA Transcripts in a Rat Model of Early Stage Colon Carcinogenesis 8321 3949 5578 5580 5581 5583 1855 5590 5601 5602 387 29127 5527 1454 2932 324 4609 51286 896 8061 3725 5328 PMC2785474__F2 TLR signaling (an example in macrophages and dendritic cells) 7097 7096 7100 10333 7099 114609 4615 54106 7098 51284 51135 3654 3656 7189 7187 29110 3661 3665 PMC2785474__F4 TLR4 and chemokine receptor cross-talk 3579 7099 156 2869 PMC2785475__F4 Expression-Based Network Biology Identifies Alteration in Key Regulatory Pathways of Type 2 Diabetes and Associated Risk/Complications 207 3667 1956 5770 3718 369 572 1856 613 2534 2241 1906 6714 2100 2885 3565 3562 PMC2785881__F3 Sialic Acid Utilisation and Synthesis in the Neonatal Rat Revisited 54187 26503 140838 10020 5973 80896 55577 55907 5238 6675 23443 10559 8473 PMC2789488__F3 Schema of major signaling pathways involved in renal development (for space and clarity, not all factors in each pathway shown) 6469 375616 6608 2737 1499 595 5979 2668 2885 PMC2794539__F5 Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells 2315 1512 3958 6272 4286 11322 1638 348 6925 3725 1462 4804 5602 5054 8828 5329 85451 6622 8904 388697 PMC2795398__F1 Endotoxin binds to CD14 and Toll-like receptor 4 (TLR4) on the surface of monocytes and endothelial cells 929 7099 4615 4513 7124 PMC2801257__F1 Signaling through the Lymphocyte receptor induces a novel regulatory motif for MAP kinase activation 933 613 930 4067 6850 5728 29760 2885 695 PMC2807318__F8 Summary of the AMPK and mTOR signaling pathways 253260 5163 2475 PMC2810404__F6 Hepatocyte expression of Serum Response Factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice 3483 3479 3486 2690 2885 2002 6722 1956 3977 891 991 9133 4171 4174 55388 4173 3294 3284 5888 7153 PMC2817557__F2 Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota 7099 3929 51135 64127 3550 3661 114609 PMC2817888__F3 ATM/ATR DNA damage response pathway and its downstream effectors leading to either G1/S or G2/M phase arrest 1017 995 993 472 545 PMC2819219__F7 Caspase Mediated Cleavage, IAP Binding and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NFKB Signaling 1611 23118 8772 PMC2820418__F12 PRG5 signaling in axon growth and neurite retraction 998 4018 387 PMC2824633__F4 Cyclin D3-specific deregulated genes and their functional networks 27250 586 25852 28514 6261 7035 84707 11078 25800 5516 23193 80854 51379 11193 1021 10550 6502 26135 1026 23766 7072 5873 10926 5325 8452 3433 23678 7644 896 PMC2829054__F7 Cdk2 Is Required for p53-Independent G2/M Checkpoint Control 990 545 84126 993 1017 983 PMC2832191__F3a Regulation of autophagy induction in yeast and mammalian cells 9776 83939 5163 3667 5728 7248 6009 7249 2475 596 PMC2834833__F3 GSK3: a multifaceted kinase in Wnt signaling 4040 4041 1499 7249 PMC2835842__F1 HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways 7098 54106 4615 6041 3661 7189 PMC2837947__F2 Disruption of metabolic pathways involved in fat pad mass trait in mouse models of the candidate genes 146198 7038 8522 2878 114294 4199 4023 719 7048 PMC2845642__F2 Molecular Mechanisms of T cell Receptor and Costimulatory Molecule Ligation/Blockade in Autoimmune Disease Therapy 920 940 27040 3932 PMC2848030__F6 How the presence of virus acts on innate immune system components, i.e 1950 3569 4938 4939 4684 PMC2849843__F2 Schematic presentation of Akt-mTOR signaling 5163 7248 7249 2475 253260 6009 PMC2852112__F2 Anti-viral and pro-viral functions of autophagy 51284 9140 9474 83939 PMC2861144__F2 Novel targets for the treatment of autosomal dominant polycystic kidney disease 3479 7248 6009 7249 3667 2475 PMC2869400__F9 A model of Gfi-1-mediated repression of CDKN1A and other Miz-1 target genes 2672 4609 1026 PMC2874225__F1 The DSBR and SDSA meiotic recombination models 23626 11144 5888 PMC2874322__F4 An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 6361 54106 4151 2056 351 3597 58484 64127 114548 91662 5925 6891 5698 3660 6890 6348 51027 90427 PMC2874439__F3 Schematic representing the significant changes in gene expression in the lung of Keap1Δ2–3/Δ2–3;CctCre+ mice compared with Keap1flox/flox mice 571 5052 2730 847 2729 2877 316 2936 2052 9588 873 4363 PMC2874810__F3 Ingenuity Pathway Analysis Network 5008 3553 2920 374 2069 6348 10135 7827 2893 5660 51284 57689 966 1950 2335 7852 846 6386 79937 5909 9123 729230 3437 5996 5816 81624 6648 169522 5743 54504 7125 9021 221692 23650 83648 9592 54205 1475 6446 10221 4792 759 153020 1843 1844 5187 1316 7538 3726 1960 64332 2874 4084 1958 2354 10481 1959 PMC2878012__F5 Model for the role of SQSTM1 in regulating the integrity of the Keap1-Nrf2 cell defense pathway 9817 8452 8878 PMC2882184__F1 Pathway analysis using all altered genes and proteins 3043 1956 3690 6154 3611 1499 6217 3206 3659 6778 6772 2099 648 5928 2956 PMC2883292__F2 Signaling through the PI-3 Kinase-Akt pathway 6714 3667 3611 5163 207 10000 208 2475 572 PMC2884164__F9 ERK/MAPK signaling pathway that is involved with pituitary adenoma comparative-proteomic data 4342 572 11101 6722 PMC2887297__F1 Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease 22926 1998 83939 468 PMC2888641__F1 Targeting Hedgehog - a Cancer Stem Cell Pathway 5727 6608 2737 2735 PMC2891948__F2 Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens 627 1812 1813 1020 PMC2892298__F8 Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors 6659 6664 6666 8463 PMC2896632__F1 Signaling pathway of the KRAS protein 1956 2885 5728 2475 PMC2897923__F1 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression 2931 4513 324 595 6925 PMC2902748__F1 Hsp90-dependent modulation of proangiogenic signaling pathways in cancer 1950 3082 2475 1956 1969 6497 6651 PMC2909599__F1 GLP-1 acts by means of the GLP-1-R to stimulate adenylyl cyclase (AC), and thereby cAMP production, and to activate the cAMP-binding proteins PKA and Epac 685 1956 2885 2549 3479 2308 3480 3170 PMC2911016__F1 “Go upstream, young man”: lessons learned from the p38 saga 1386 2002 9261 PMC2911442__F5 WRN participates in the regulation of PCNA mono-ubiquitination and subsequent TLS through interaction with PCNA 56852 472 7486 5111 PMC2912210__F1 Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response 1956 2885 4763 2002 4609 2353 PMC2915454__F4 Pathways underlying absorption of cholesterol from the intestinal lumen and its delivery to the liver 64241 64240 29881 39 4547 PMC2919370__F4 Fanconi Anemia Proteins and Endogenous Stresses 84126 545 2175 55215 2178 PMC2921576__F1 Schematic representation of hepatic methionine metabolism 27232 4837 875 635 4397 PMC2921989__F2 Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein 3486 5163 5164 6009 4193 581 PMC2923738__F4 Human erythrocyte metabolism modeled using detailed enzyme rate equations 22944 2821 10750 2597 5232 PMC2929310__F6 Transcript abundance patterns in Kawasaki disease patients with IVIG resistance 7124 84890 4149 1386 PMC2933224__F1 Gradient Descent Optimization in Gene Regulatory Pathways 837 1616 839 8772 836 355 840 8717 835 842 PMC2933845__F4 Genistein inhibits critical pathways in cancer invasion 4088 4086 9261 PMC2939232__F10 Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2) 2475 29904 1938 PMC2943318__F7 Ulk3 function in Shh signaling pathway 6469 5727 6608 25989 2736 51684 PMC2945029__F6 Pathways and networks related to chondrocyte proteins identified by proteomics as altered by GS and/or CS 3315 301 2923 302 6648 60 308 2950 5230 226 5223 PMC2949087__F5 Mitochondria and neuroplasticity 3064 351 120892 65018 627 7018 PMC2949529__F2 O-GlcNAc Signaling: A Metabolic Link Between Diabetes and Cancer? 3667 5163 2932 8473 PMC2950652__F2 Pioneer Round of Translation: Features and Functions 1975 27250 9811 1999 4116 1998 26986 PMC2953417__F1 REGULATION OF NITRIC OXIDE PRODUCTION IN HEALTH AND DISEASE 435 5009 7808 PMC2958833__F2 Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus 3717 5163 2932 7249 7248 6009 627 253260 2885 2002 6095 6256 5465 9575 406 PMC2963177__F2 Integration of non-SMAD and SMAD signaling in TGFB1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells 1956 4088 4089 4087 387 5494 PMC2965861__F1 The AMPK pathway in relation to various molecules 6794 2194 7249 2475 PMC2981507__F2 Therapeutic interventions for fragile X syndrome 7249 7248 6009 2475 1977 PMC2991775__F1 Pathways leading to the type I interferon production 3146 7099 929 114609 3586 51311 51284 7098 54106 7187 9447 695 6696 23118 29110 10010 257397 6041 6035 57506 8772 83939 3663 3665 3661 PMC2993798__F6 A conserved insulin signaling pathway in C 3643 5163 207 6446 PMC3004747__F1 Fucose is on the TRAIL of colon cancer 1950 4035 23275 2530 23509 PMC3008507__F5 A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets 1836 84233 26289 1725 64403 11211 6241 4040 7358 999 1499 2162 4166 6615 217 8326 2535 3398 10544 22874 4512 5781 1044 3726 3214 10156 2953 5347 4248 5016 6504 5934 11314 5925 4056 10538 432 9466 81618 5029 4880 390 55297 9043 139818 4921 51450 9211 11030 2976 7532 23077 4312 2130 54809 5465 11214 1432 6741 2706 4188 11178 26959 2705 2975 3976 6908 2972 1981 199 100506658 688 1978 65108 9328 10623 3603 10381 6194 10205 3766 22872 10621 4254 1983 10112 4869 6128 8662 11120 1975 80318 27040 3956 2781 7462 7345 22938 5799 2159 3175 79073 5271 8500 7189 11331 9733 5054 6288 350 10096 9542 116138 11284 57194 7372 2297 11200 10810 4678 10602 2697 57198 PMC3018616__F1 TGFB superfamily signaling pathway 7939 5340 4087 4088 4092 4091 4090 4086 4089 PMC3018769__F8 Composite figure from all time points of microarray data showing apoptotic pathways in HepG2 cells when exposed to PCB-153 (70μM) and PCB-77 (70μM) 7040 7124 10628 8743 841 207 3725 1543 2353 596 598 637 4495 4501 3596 1437 8477 361 360 196 581 836 405 4791 2736 117581 1385 6908 4609 10397 PMC3022058__F1 Outline of UDP-GlcNAc synthetic pathways 101448070 2539 10020 8473 PMC3024260__F1 Computational and Experimental Study of the Regulatory Mechanisms of the Complement System 5091 1401 720 718 721 717 PMC3025761__F1 Schematic illustration of the various steps involved in the ubiquitin proteasome pathway and general architecture of the cullin 1 (CRL1) and cullin 4 (CRL4)-based E3 ubiquitin ligases 1642 5111 6500 9978 PMC3046768__F2 Schematic of the base excision repair pathways present in mitochondria 2922 1763 2237 PMC3046919__F7 Proposed model of the process of A20 4089 4087 4088 PMC3047603__F3 CYP17 inhibitors for prostate cancer therapy 115209 1583 6715 3284 3293 5959 PMC3048376__F5 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli 3569 7039 3479 3586 2475 6774 PMC3048376__F9 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli 3586 3479 7039 3569 7189 6774 2475 3565 3458 3553 PMC3053348__F7 The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation 7097 4615 6285 7098 54106 PMC3053440__F1 Toll-like receptor signaling pathway 7099 4615 114609 7189 51135 7334 10454 23118 257397 3661 3663 PMC3060910__F1 Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells 390992 324 388585 84667 1499 3955 5986 4242 9794 26508 23462 23493 8650 9253 PMC3065454__F8 Advanced Computational Biology Methods Identify Molecular Switches for Malignancy in an EGF Mouse Model of Liver Cancer 102 1950 2885 3481 3643 3716 6773 3717 5058 207 6774 3667 6714 7189 5163 51701 2625 468 466 4303 PMC3065765__F3 Iron in regulating the mTOR signaling pathway 51052 5170 5728 54541 7249 7248 6009 253260 PMC3066660__F6 Significantly expressed genes in cytokine–cytokine receptor interaction pathway disturbed by SM at different time points 7124 6346 6750 3082 268 4804 4254 2322 4055 49 355 3952 2056 2057 10913 1896 5617 7173 4352 5008 6361 PMC3070611__F3 One experimental result of identified pathways from ovarian expression data 1052 2885 2549 PMC3070849__F1 Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation 930 695 3716 6850 29760 5163 3662 3394 5266 5728 2308 57379 10113 PMC3071576__F2 Proof of Concept Trials in Bipolar Disorder and Major Depressive Disorder: A Translational Perspective in the Search for Improved Treatments 100170220 4666 5662 PMC3072784__F8 A kinase cascade regulating pIgR transcytosis 5277 5284 8766 1956 PMC3074954__F1 ROS have different origins 6741 3980 7515 11284 142 54840 5423 5111 2237 PMC3075080__F3 Proposed ACE2/ANG-(1–7)/Mas signaling pathways in the central nervous system 4295 1636 59272 6774 PMC3075376__F1 Targeting GSK-3 family members in the heart: A very sharp double-edged sword 4041 324 1499 4609 PMC3075579__F4 The PI3K pathway in TLR-signaling 4118 4615 5163 5728 7189 6009 3661 3553 PMC3075605__F2 NFKB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28 7099 940 5163 3932 8717 7186 4615 51135 3654 8915 10892 7189 10454 23118 257397 1540 27005 PMC3076503__F4 Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hippocampus 2181 130 23305 1374 2597 10449 2876 2954 4285 529 91647 27068 1431 1345 1347 1355 18 7386 6390 6391 4694 4697 4705 51103 4716 4720 8803 4967 2571 83733 1644 3099 8569 2885 2002 189 5467 6256 PMC3076503__F5 Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hypothalamus 3099 130 217 1892 1962 10449 1737 2954 91647 27068 1431 1355 10063 7386 18 4694 140805 4705 4716 4719 4720 4723 2571 83733 2875 1644 5291 8503 189 2885 5605 5467 27165 PMC3077564__F3 Activation of glia and neurons in the dorsal horn of the spinal cord after peripheral injury 627 6347 1524 3084 156 2064 729230 PMC3077819__F2 Widespread extracellular matrix (ECM) pathway silencing by DNA hypermethylation in colon cancer 2821 718 5979 135228 51466 4827 2201 2318 10457 4314 1404 3486 284217 7448 22854 4897 1499 7078 7077 6678 5328 5340 PMC3077922__F3 Gene expression changes in response to zebularine therapy in vivo 84233 23309 27258 22803 27257 1495 7298 831 55215 8409 7150 4686 3187 307 824 4609 6159 6185 7703 9320 22822 6733 55364 10390 11331 4259 4653 5757 PMC3078523__F2 Heme Oxygenase-1, a Critical Arbitrator of Cell Death Pathways in Lung Injury and Disease 572 581 637 PMC3081173__F4 Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology 7448 387 998 10253 PMC3082570__F1 Simultaneous siRNA Targeting of Src and Downstream Signaling Molecules Inhibit Tumor Formation and Metastasis of a Human Model Breast Cancer Cell Line 6714 6774 595 572 2475 2353 PMC3088358__F7 The extracellular network of proteins that control D–V patterning 650 652 655 PMC3088722__F6 Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells 2620 11156 900 2071 835 7709 22955 8738 26524 1019 57448 1032 1643 4692 1026 5934 7045 7157 5558 6909 10664 94241 1163 2972 84678 9538 23567 25932 5178 PMC3091413__F4 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Caucasian population 5728 5747 4436 890 1877 10919 641 7507 2099 6117 1477 2074 7516 5934 9641 7518 25 6648 7431 5933 2897 1742 5591 1869 7486 545 6502 1107 1147 836 960 6597 4193 367 5599 1017 472 84515 3479 580 2547 5981 4292 11200 837 5925 7329 4854 5111 4609 4853 2932 7186 55294 28514 9794 1788 2956 2073 23139 5894 182 4851 331 23493 8650 993 3065 PMC3091413__F6 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways 7518 6118 5728 2099 7507 7486 472 1111 5925 595 2175 7158 6117 4436 5888 6502 545 1869 2547 7157 6597 367 2033 55294 4851 1017 5981 5591 8650 4854 3486 841 1387 4853 2066 672 5111 182 7316 890 4255 1026 4193 PMC3091413__F7 Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways 28514 4853 2547 898 4854 23493 7423 8829 4214 8650 5663 3551 65989 1027 3714 28996 55294 182 2289 4605 6502 7531 8454 1028 5359 7040 835 5728 83737 367 9961 7186 1163 5934 5747 7448 7422 3065 7329 5888 5933 5599 1869 672 5594 2874 2932 3308 10928 6597 836 6908 1017 890 842 7316 1022 840 6996 1025 331 8837 2033 9112 2263 902 1387 573 1107 2965 10273 PMC3094203__F3 Peroxisome proliferator-activated receptor G (PPARG) is a ligand-activated nuclear receptor with potent anti-inflammatory properties that modulates the immune inflammatory response 3586 3565 948 9332 PMC3094853__F1 CHS-catalyzed synthesis of unnatural polyphenols from cinnamoyl-SNAc starter substrates with a) malonyl-CoA and b) methylmalonyl-CoA as extender units 100188864 10692 3550 PMC3097535__F5 Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities 1356 4312 1136 6772 5467 PMC3106121__F1 Phosphodiesterases and Cardiac cGMP: Evolving Roles and Controversies 7225 5997 5999 2626 PMC3108205__F4 Delay in apoptosis at 9 hr 7124 355 831 637 572 581 2021 4170 56616 27429 351 790 PMC3108840__F6 Functional pathway analysis of glycoproteins overexpressed in PC3-N2 5064 1604 3703 1785 57674 3936 9632 81502 1500 54881 23511 55660 PMC3116111__F1 Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell 85413 5243 6647 10928 9429 1244 4363 2876 4846 7498 4790 4292 4436 7153 2068 7157 847 PMC3116140__F2 The core pathway of Notch signaling 8650 388585 3280 3516 PMC3117317__F3 NFKB signaling pathway 1950 4803 7039 7124 4055 958 3932 5970 5971 63827 PMC3118436__F2 Metabolic remodeling in cancer cells and regulation by signaling pathways involving oncogenes and tumor suppressor genes 3099 4609 2539 5209 8277 57103 355 3939 5163 3418 3417 2744 PMC3119709__F1 Macrophages as a Battleground for Toxoplasma Pathogenesis 6774 6778 383 51561 8835 3569 1437 PMC3122959__F1 Hedgehog signaling in skin cancers 6608 91653 2619 596 2932 51684 51715 374654 PMC3124653__F1 Systems pharmacology assessment of the 5-fluorouracil pathway 51733 1807 1806 7083 2232 356 7378 7372 4790 7371 7374 7157 7298 1854 1841 8836 4524 4831 2356 4830 1719 6240 6241 PMC3124653__F6 Systems pharmacology assessment of the 5-fluorouracil pathway 1807 51733 1806 7083 2232 356 7378 7372 4790 7371 7374 7157 7298 1854 1841 8836 4524 4831 2356 4830 1719 6240 6241 PMC3127207__F4 GenMAPP Diagram of Cell Cycle Pathway Genes Regulated by Luteolin in E2-Treated MCF-7 Cells 995 5111 994 891 993 9133 2932 9134 896 8900 902 85417 894 898 890 1017 5347 1019 1021 990 25 7465 5925 6502 5933 8317 7027 PMC3128083__F9 RIG-I Mediates Innate Immune Response in Mouse Neurons Following Japanese Encephalitis Virus Infection 23586 8772 7189 7186 PMC3131090__F1 Negative regulation of the autophagy pathway 2475 9140 8408 64422 PMC3133775__F2 Second messengers and membrane trafficking direct and organize growth cone steering 7220 1630 4803 4099 10371 627 7222 7225 PMC3133937__F1 Concerted regulation of the WNT-DVL-GSK3B signaling pathway in NAc by chronic social defeat stress 54361 8313 8312 5626 1499 PMC3136090__F5 Signaling schematic representation: The postulated signaling pathway involved in this study 7275 1017 6010 PMC3136489__F10 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood 2885 4067 1445 5728 695 29760 5336 2475 572 85451 2113 1958 PMC3136489__F11 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood 570 940 7006 100124696 2534 7535 6461 3932 2885 3702 6503 27040 2922 2002 PMC3138766__F6 JAK2 V617F-Dependent Upregulation of PU.1 Expression in the Peripheral Blood of Myeloproliferative Neoplasm Patients 3717 25 6776 6777 6774 9021 PMC3139433__F4 Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes 57178 331 4089 8089 1026 2735 7335 7204 1111 1649 7124 7008 5443 2619 2353 5591 55703 8841 404281 6648 7422 661 6885 3217 5600 5925 108 8828 10955 4609 3725 4149 3265 2247 673 355 5894 54575 2885 2263 6792 22985 6256 10567 3932 7341 8644 2534 5864 6714 2902 9753 1123 2064 7018 1499 5029 9647 8927 3667 3791 5289 PMC3141289__F1 Signaling pathway leading to signal transducer and activator of transcription (STAT)-3 activation (see text for definitions of abbreviations) 1270 1950 7039 1956 6774 PMC3152951__F1 Interaction between HCV and Nuclear Receptor-mediated Pathways 948 1581 5465 355 PMC3157546__F7 The role of TAK1 signaling in bone metastasis 23118 10454 4318 4513 7124 PMC3159954__F2 Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa 7297 3716 6773 10379 3437 5696 PMC3164457__F5 Mi-2/NuRD complex depletion in germinal center B cells leads to alterations in chromatin, checkpoint activation, and delayed progression through S phase 1108 472 9869 5888 993 891 8318 1017 PMC3166557__F2 Planar Cell Polarity Pathway – Coordinating morphogenetic cell behaviors with embryonic polarity 7471 57216 7481 23002 6010 324 4920 1499 10399 5754 PMC3169181__F2 Crosstalk between host autophagy and viruses 9474 9140 64422 2475 920 PMC3169508__F2 An indirect interaction between the Axon Guidance and Insulin Signaling pathways in the network for the comparison between HF and LF diet at t = 0 998 23678 2932 2242 2308 7248 7249 PMC3169508__F3 Pathway interactions and detailed network visualization for the interactions with three apoptosis related pathways for the comparison between HF and LF diet at t = 0 355 5590 1504 4893 1432 203068 2932 5583 6654 3728 3845 5062 840 208 1147 3654 4214 22919 9702 10733 9261 5573 PMC3169732__F6 Schematic diagram illustrating the proposed signaling pathway involved in cigarette smoke extract-induced increase in expressions of inflammatory genes in airway smooth muscle cells 4615 7189 7099 PMC3174204__F6 Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs 545 472 8626 7276 572 5728 8575 PMC3176435__F2 Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants 4553 192670 192669 PMC3179949__F6 A schematic representation showing 17Beta-estradiol inhibition of uPA and MMP-9 expression, and cell motility via suppression of JNK1/2 pathway in human LoVo colon cancer cells 4828 7076 7077 7078 PMC3185489__F4 The effects of HCV on steatosis development 5465 355 6319 338 PMC3189939__F3 CAFET Algorithm Reveals Wnt/PCP Signature in Lung Squamous Cell Carcinoma 1499 6424 83999 1952 6259 81839 817 5578 998 387 PMC3202828__F5 Cif hijacks several and various signaling pathways by inhibiting the ubiquitin ligase activity of CRL 1499 387 81620 PMC3205057__F6 Influence of miR-300 on apoptosis pathway 355 8717 8772 572 PMC3205057__F8 Effect of miRNAs on cell cycle, proliferation, and differentiation 3475 860 3624 1901 3716 5934 7057 894 79711 7837 663 898 7368 9212 8202 1869 1871 5465 5901 8626 4343 8742 1022 PMC3205232__F1 A brief survey of mRNA surveillance 10743 131870 167227 28960 PMC3206090__F2 Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development 3064 351 9001 4803 627 PMC3206369__F1 Primary phosphatases function as tumor suppressors and their signaling pathways 8821 5266 5728 7249 1499 6009 2475 PMC3210079__F8 Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells 7291 2043 4853 3280 1499 4086 4088 PMC3213081__F1 The P2X7 Receptor in Infectious Diseases 114548 387 3553 1051 383 PMC3216306__F1 Downregulation of macrophages signalling by Leishmania infection 7099 929 51135 3656 7189 29110 3661 4615 114609 3717 PMC3217209__F1 Insulin Resistance, Hyperglycemia, and Atherosclerosis 8544 2475 7412 338 PMC3218884__F4 Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA 7431 4000 5928 5925 7913 811 2521 3066 5094 8570 3191 6648 283571 3178 PMC3221598__F3 Protease Regulation: The Yin and Yang of neural development and disease 351 1630 6714 PMC3222852__F1 GSK3 plays pivotal roles in the establishment and maintenance of neuronal polarization 5728 7249 7248 6009 2475 324 23303 PMC3227962__F5 Targets for intervention in the TGFB1 pathway (partial list) [, , ] 4092 6010 5062 6093 2475 PMC3228878__F1 Several types of TG2-containing adhesive / signaling complexes present on the cell surface 4035 4040 4041 207 6714 1499 387 PMC3236209__F6 Transcriptome Analysis of H2O2-Treated Wheat Seedlings Reveals a H2O2-Responsive Fatty Acid Desaturase Gene Participating in Powdery Mildew Resistance 95 4015 4602 2077 PMC3236456__F3 Hypothetical model for a molecular chitinase response to chitin-containing pathogens or particles 7097 5970 3662 1118 PMC3243745__F6 Metabolic pathways illustrating TCDD-elicited changes in the mouse (A) and rat (B) 100873790 229 230 2597 3990 4023 9663 84649 283871 5478 55349 64853 5058 2820 150763 1119 PMC3245324__F2 Ischemic preconditioning (IPC): signaling pathways and targets 2475 5163 5728 6714 PMC3248194__F3 RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death 355 7186 8772 1540 23118 257397 2752 5836 PMC3248195__F1 Elevated PI3K signaling drives multiple Breast Cancer subtypes 3480 5728 3667 8821 2549 7249 7248 207 208 572 3486 3484 PMC3249400__F1 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism 10645 9759 10014 51564 200186 5209 2997 23216 2309 1407 7249 3667 8729 5337 64837 8408 PMC3249400__F2 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism 23118 10454 4763 5728 472 5163 2534 7249 7248 6009 2475 201163 9776 8408 96459 PMC3249400__F4 AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism 10014 1407 23411 2194 PMC3253327__F2 Acute and Chronic Regulation of Aldosterone Production 5091 6770 4158 PMC3256998__F5 Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells 4282 4513 972 PMC3256998__F6 Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells 3929 5058 6722 2002 PMC3257109__F3 BMP signaling in motor neurons 7204 655 650 4090 4086 3984 4089 PMC3258560__F1 Signal transduction by TGFB family members 6010 4092 4090 4086 4087 4088 4091 PMC3261278__F1 Synaptic translation and signaling pathways modulated by FMRP (a) and dysregulation of these pathways in the absence or significant reduction of FMRP (b) 351 1740 1977 4318 23237 PMC3262938__F2 N-glycan biosynthetic pathways in eukaryotes and glycoengineering 2592 55329 10195 PMC3266662__F3 Correlations of genes in central carbon metabolism with SPPR 6120 2695 6886 11113 5230 100996949 27040 2023 2026 2019 2020 4118 PMC3268901__F1 The PTEN/mTOR signaling pathway 7039 5728 2475 406991 406998 406999 PMC3272624__F1 Schematic depicting mTORC1 signaling in a NAC a medium spiny neuron with anterogradely transported BDNF being released from a VTA dopamine neuron terminal and glutamate released from a prefrontal cortex projection neuron 627 5163 6009 7248 7249 2475 PMC3274818__F1 Activation of an RTK induces dimerization and downstream phosphorylation of non-receptor tyrosine kinases 1956 9846 5728 4763 998 6010 PMC3278537__F2 Signaling Pathways Underlying the Pathophysiology and Treatment of Depression: Novel Mechanisms for Rapid-Acting Agents 627 2885 2549 5163 5728 PMC3279755__F1 Signaling pathways of the fibroblast growth factor receptor in neural stem cells 2885 2549 867 PMC3285553__F3 Additional mechanisms by which Wnt/Beta-catenin signaling can be modulated in cancer 3082 6608 4851 1499 324 PMC3287586__F2 Preimplantation development pathway 1786 1499 999 2707 4609 56288 652 3398 10284 9421 10072 4086 174 3914 2249 3976 3977 2103 6774 2624 6657 79923 9314 6208 7004 8521 7089 6929 27022 7070 10637 8320 3875 7044 4513 5670 1045 6615 9350 2626 1824 2248 1601 64321 PMC3289598__F1 Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background 358 875 1431 PMC3289952__F2 Proposed role of essential fatty acids in “micromanaging” molecular actions 2854 29102 54487 27250 27161 5728 1027 1051 PMC3295664__F1 Methanol utilization (MUT) pathway in P 316 2203 7167 PMC3296202__F1 Pathways involved in diabetes-induced EPCs toxicity and possible strategies to reverse EPCs damage during bone marrow mobilization 1636 4318 2739 6098 7852 PMC3297581__F6 Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line 6932 861 2004 860 3659 6095 5467 1050 3725 2313 6774 3131 1053 5966 2078 PMC3303581__F1 Myostatin signals through the ActRIIB-ALK4/5 heterodimer activate Smad2/3 with blocking of MyoD transactivation in an autoregulatory feedback loop 1636 3479 4087 4088 6009 2475 PMC3303816__F3 Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis 55294 6478 8573 5413 PMC3304298__F1 AKT signaling pathway 613 930 3716 6850 4067 253260 3611 2475 5728 5163 7249 7248 51083 27250 331 4193 5208 572 581 4661 595 2549 9846 3667 PMC3306451__F2 Integration of mitochondrial oxidative and antioxidant pathways by PGC-1A 23410 5465 23411 PMC3309175__F7 Mammalian target of rapamycin (mTOR) signaling pathway for the regulation of skeletal muscle protein synthesis in response to growth factors, nutrition, and mechanical stimuli 5337 2475 1998 1938 6194 PMC3310826__F16 Schematic showing alterations to the TAG biosynthesis pathway in AS11 when DGAT1 activity is absent 5091 8694 54947 3931 4018 PMC3316934__F4 Significant differences in mRNA expression were seen for genes involved in the JNK signaling pathway between tumors arising in different CNS locations 2885 1398 8772 8717 1616 1399 3932 7186 2549 10454 3667 1386 2002 4772 PMC3317229__F3 JNK signalling pathway (adapted from http://www.sabiosciences.com/) 2885 5879 998 PMC3326643__F2 Targeting Mnks for Cancer Therapy 5728 4763 5163 7249 7248 6009 3667 1977 1999 1975 27250 PMC3328302__F7 Schematic diagram illustrating the proposed interaction between CDH17 and Wnt/Beta-catenin pathway during HCC progression 1499 4513 324 595 5111 PMC3328890__F1 ROS-dependent and -independent apoptosis induced by particulate pollutants 4151 196 572 581 4170 PMC3331679__F2 mTOR signaling in growth control and disease 5728 4763 8491 253430 6446 7249 7248 6009 1975 9776 8408 29904 27250 1977 84232 1938 6010 7528 PMC3334602__F10 Putative signal transduction pathways regulating fruiting body development in C 998 6010 1022 PMC3337981__F8 BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NFKB pathway 613 958 4615 7187 8915 10892 7189 7186 5971 57379 PMC3338196__F3 Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation 5091 11113 4118 PMC3340364__F6 Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells 545 842 836 574449 PMC3342364__F2 Molecular mechanisms mediating the regulatory effects of hypoxia 6347 8434 4481 6890 7077 4843 383 PMC3347317__F2 Modulation of type I IFN production by PRRSV 3466 7297 3716 7098 6041 6035 7187 2814 29110 3665 3661 9636 PMC3348077__F7 Signaling pathway for the cytoprotective effect of STI571 in TRAIL-treated colon cancer cells 8717 8772 7186 PMC3348384__F1 miRNAs and estrogen action 29102 54487 2521 2130 4691 5901 100187761 27161 PMC3348998__F1 Lipids and Prostate Cancer 3099 3156 31 2194 47 4199 6319 48 3417 3418 PMC3351834__F2 Transcriptional changes in TGFB1 signaling pathway 8646 656 655 4093 392255 3400 268 151449 652 4089 659 650 353500 3398 3399 9241 269 654 653 9978 3458 4091 7057 5595 4092 7124 7059 6500 64750 1311 4088 4087 1874 4609 7058 1875 7060 9765 7042 7027 9372 7043 1634 7046 7048 7040 387 9475 2033 3624 5516 5515 3625 6199 6198 7044 3626 83729 92 10468 4838 93 5308 PMC3355940__F2 K63-linked polyubiquitination in the activation of canonical and non-canonical NFKB signaling pathway 7124 958 7186 3654 1540 PMC3356006__F2 Central regulation of leptin signaling, autonomic innervation of the adipocyte and Beta-cell, and the starvation response 4023 7038 4082 PMC3359066__F5 Identification of Functional Differences in Metabolic Networks Using Comparative Genomics and Constraint-Based Models 210 4200 4118 PMC3361623__F1 A New Framework for Understanding IRES-mediated Translation 1999 7458 1975 2001 1983 PMC3364883__F5 Gene expression alterations in Manf mutants with a linkage to Parkinson's disease 7873 6622 842 PMC3365480__F1 Pro- and anti-inflammatory effects of heat and heat shock proteins 929 3553 3146 7189 PMC3368236__F5 Sema3E-PlexD1 signaling regulates pathway-specific synapse formation in the striatum 9723 1812 4478 PMC3377094__F2 Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins 7099 114609 51284 54106 7098 4615 7189 29110 23118 257397 373 5987 6737 5970 3394 3661 3663 3665 PMC3382253__F4 Mitochondria biogenesis allows tissue adaption under stress 4089 4087 4088 PMC3384412__F2 UPR signaling in diseases 83939 468 7494 PMC3390254__F1 An emerging role of mTOR in lipid biosynthesis 2475 64223 64798 7249 7248 6009 6446 PMC3398465__F4 Systems analysis of salivary gland development and disease 6469 1950 1839 2335 10512 10371 10913 999 5361 6608 1495 3675 10252 652 1431 2737 PMC3398916__F7 The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network 7074 2932 324 998 PMC3399091__F1 PAK1 Molecular Pathway 5058 572 10395 3925 5894 5093 2316 10095 1020 PMC3399530__F2 Gene expression alterations in Rocky Mountain elk infected with chronic wasting disease 4744 5630 3398 4741 5595 4494 4929 1028 6647 1431 5430 50863 8887 6622 6386 830 6616 2664 3936 5121 388 6010 5962 10457 85477 6863 57471 2778 4099 PMC3408479__F8 Endoplasmic Reticulum Stress Stimulates p53 Expression through NFKB Activation 468 83939 7186 22926 PMC3413225__F7 Model describing the mechanisms of quercetin-induced cholesterol efflux in macrophages 19 6667 2638 PMC3426490__F2 Flow chart showing the genes involved in TLR signaling pathway 7098 8772 3569 114609 7939 929 23118 958 2717 PMC3429940__F1 Optimizing treatments for lymphangioleiomyomatosis 7248 5163 7249 1017 6009 6010 3091 PMC3433932__F3 The scheme summarizes the stretch-induced pathway that allows ROS scavenging in response to mechanical stimuli 1958 23411 6648 PMC3434621__F5 Interactions of Rex with host pathways, uncovered and covered 6672 84445 1499 10054 9063 PMC3439136__F2 TAP-MS PPI RTK-Ras-ERK signaling network 6156 3098 9973 8841 1956 5817 6232 10762 202309 6168 6950 6139 6144 6128 6152 6147 6138 445347 6395 6184 6122 10399 11140 6222 6158 6155 6908 6396 6133 6231 6224 10048 6161 5984 PMC3439136__F3 Additional analysis of the PPI network 6156 1956 5817 6128 6139 6168 6101 6147 10399 6222 6122 6155 6133 4176 6224 6161 6395 PMC3439334__F6 Immune response pathway map enriched with genes down-regulated in the tumorgraft forming patient tumors 3133 3383 7409 3265 126669 4214 1386 2353 3458 PMC3439646__F1 Complement and dysbiosis in periodontal disease 929 7852 7099 5879 7096 7097 3659 2932 3458 PMC3442742__F1 NGF signaling pathways in mediating neurotrophic and nociceptor effects.Notes: NGF signals through the high-affinity TrkA and low p75NTR receptors 4803 7442 5163 PMC3459479__F1 RAS pathway and its correlation with RASopathies 5921 2885 1431 867 6654 8036 673 161742 PMC3464048__F1 Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets 637 6774 2475 5894 8772 355 PMC3472459__F5 Coordinate regulation by NR signaling pathways of genes encoding enzymes in the de novo purine base biosynthesis pathway 367 5468 3172 6470 5631 5471 2618 10606 158 471 8833 PMC3472558__F1 EGFR signaling pathway (reprinted with permission from BioCarta Pathways 1950 2885 3716 5894 6774 2353 2002 6722 PMC3476735__F5 Metformin, an anti-diabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway 3479 3667 7248 207 10000 208 7249 6009 595 PMC3478884__F1 Emerging role of nuclear architecture in DNA repair and genome maintenance 4361 10111 472 545 84126 9025 PMC3482685__F2 Regulatory function of TIR8/SIGIRR in signaling 59307 7099 54106 7098 7097 7100 51284 4615 2475 595 PMC3484676__F3 Rbf1 occupies multiple nodes in conserved signaling pathways 6009 5163 23235 8027 7249 7248 5728 55486 57534 5045 351 4734 23558 23013 PMC3486512__F3 Network analysis of the host factors found to be associated with the extremities of the murine norovirus genome 1654 6147 1660 5610 3069 6154 5814 7094 2521 10492 10236 4904 3190 3185 221092 1655 3181 5094 5725 5777 10342 3192 10130 2771 2193 5093 8761 5880 1938 8570 301 3178 4670 3182 653361 26986 2194 5034 3320 3184 26156 57142 3839 1937 1915 3326 10016 26354 3837 7812 7919 3312 10015 10576 908 PMC3491811__F3 Calcium regulation of keratinocyte differentiation 1499 6010 2534 6714 999 PMC3492658__F1 NOD1 and NOD2 signaling pathways and interaction partners 1611 3553 3661 64170 637 64127 8767 10392 114548 57506 9474 9140 PMC3493339__F4 STRING Network 7316 2060 7039 867 5335 54206 4690 2064 1956 2885 2069 6464 6714 5777 5781 5770 6772 6774 PMC3493640__F1 Multi-omic map of the lipid-producing yeast Rhodosporidium toruloides 3099 3098 2597 4191 355 2078 50 3422 3652 PMC3497272__F2 ErbB signaling and inhibition in tumour cell 2065 2064 2549 2885 9846 6774 572 581 596 PMC3498232__F9 Expression Profile in Rice Panicle: Insights into Heat Response Mechanism at Reproductive Stage 2665 57716 847 2077 4602 PMC3499662__F1 Cell-signaling pathways from the UPR to autophagy and ER stress-induced apoptosis 581 7186 7494 175 PMC3499881__F1 Regulation of the polyamines putrescine, spermidine and spermine by biosynthetic enzymes (shown in green) and catabolic enzymes (shown in red) 85413 4953 262 196743 6723 6520 6611 54498 6303 PMC3514292__F1 Schematic representation depicting A; the protein synthesis pathway in skeletal muscle involving the mammalian target of rapamycin complex 1 (mTORC1) 2475 3667 5163 7248 7249 6009 1975 3479 2309 2308 23411 PMC3518582__F3 Wnt7a signals bidirectionally through divergent pathways to influence both presynaptic and postsynaptic assembly and to promote excitatory synapse formation and function 4131 2932 7476 PMC3523725__F7 PPARG COUNTERACTS LRP1-INDUCED VASCULAR CALCIFICATION BY INHIBITING A WNT5A SIGNALING PATHWAY 6423 4035 6662 PMC3524689__F2 Proposed model of OGP(10-14) differentiation signalling 7173 4352 4351 387 7040 PMC3530773__F3 Vasopressin signaling network 6261 2778 815 5062 572 50488 7159 5257 9209 1432 51666 PMC3532163__F4 Characterization of the Phosphoproteome in SLE Patients 4803 627 4351 1956 1950 4342 3725 7124 7186 355 4149 929 51295 51701 PMC3535741__F1 PI3K/AKT/GSK3/mTOR signaling 5728 7248 7249 2475 1499 PMC3540170__F4 Immunoregulatory role of anchored cAMP signaling in T cells 50943 7099 929 920 3932 PMC3546980__F7 Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo 7076 6469 6608 374654 51684 2736 2475 4609 PMC3562341__F4 Accumulation of Splice Variants and Transcripts in Response to PI3K Inhibition in T Cells 940 2534 7535 6461 3932 2885 27040 7006 100124696 3702 2922 5778 2002 PMC3567093__F6 Somatostatin Derivative (smsDX) Targets Cellular Metabolism in Prostate Cancer Cells after Androgen Deprivation Therapy 2746 3417 3418 2539 39 2023 PMC3569116__F1 Glucose metabolic pathway 230 7167 2597 5230 5223 2026 1738 PMC3570128__F2 Wnt signaling affects c-Myb stability and activity 28996 55294 51701 PMC3572906__F3 Microbial Cell Components Induced Tolerance to Flagellin-Stimulated Inflammation through Toll-Like Receptor Pathways in Intestinal Epithelial Cells 4615 695 54472 51135 7186 3656 8772 4214 9448 51295 23118 3661 3725 3627 114609 929 PMC3576027__F2 Activity-dependent neuronal signalling and autism spectrum disorder 627 7249 23237 7248 2475 7337 PMC3580185__F7 Working model for the role of TAK1 lysine-72 in the negative regulation of TNFAlpha-induced NFKB activation 7124 23118 3550 5970 5966 8717 7186 PMC3580432__F2 Possible key signaling components in the force-mediated stem cell differentiation 7408 25777 23353 4018 29 387 718 860 PMC3580761__F2 Regulation network of CYP3A4 phenotype expression adapted from Klein et al 10599 28234 7421 3557 11309 7391 5465 6256 5914 3171 10682 3572 3569 3570 405 407020 5447 211 3163 10857 10424 PMC3580884__F3 Relationship between binding of ligands to the pattern recognition advance glycation end‐product receptor (RAGE), and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro‐ and microvasculature 23237 3146 4691 1958 PMC3581603__F6 Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells 581 2475 6194 PMC3583110__F2 Intrinsic and extrinsic apoptotic pathways 8772 8717 637 581 PMC3583581__F2 Recent advances in prostate development and links to prostatic diseases 655 367 4313 6423 6422 6608 6469 PMC3587843__F4 Lipids in The Control of Autophagy 5091 5337 5266 200576 PMC3588179__F2 T-cell immune regulation by IDO1 325 930 5132 PMC3590201__F1 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations 4781 1610 627 1950 2316 3725 1386 1537 7124 1616 4149 4208 23118 51295 51701 PMC3590201__F2 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations 4089 3458 4091 4092 6500 4052 387 10468 5308 4838 PMC3593087__F3 Cross-talk between insulin/IGF-1, BMP2, and Wnt signaling pathways 3479 650 4090 4086 2885 3667 5728 4089 324 1499 860 7018 5251 3381 238 7421 PMC3594751__F7 Schematic view of the roles of S-PCNA and Srs2 in the rescue of stalled replication forks 5111 5888 56852 353497 118027463 27434 PMC3598339__F2 Pathway analysis identifies a network of genes related to lipid metabolism in islets cultured at 5.6 mM glucose concentration 529 230 27346 255738 134429 6721 5764 5728 55902 10654 997 7124 50814 9892 6720 6319 65985 2033 6449 3638 6938 51141 2167 7480 PMC3598339__F3 Network related to lipid metabolism in islets cultured at 23 mM glucose concentration 9159 7529 572 54206 3150 581 84612 10134 599 6720 6422 998 596 54205 5468 2167 335 23191 5465 3991 56288 336 229 PMC3598339__F4 Network related to cell cycle and cell death in islets cultured at 23 mM glucose concentration 5621 102 1365 7082 4869 6648 23394 837 1999 9444 10400 26227 3162 6773 4353 3934 1604 8772 6385 9994 3991 596 2033 351 4814 7174 2167 9423 4609 4519 7071 29978 PMC3598852__F3 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis 387 7408 3611 5728 3725 1398 126669 572 PMC3598852__F4 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis 51701 5624 4089 4088 324 9350 3952 6500 8454 6477 2040 9475 387 23002 PMC3598852__F5 Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis 4781 627 4351 2885 6722 5894 2316 7124 2645 355 1616 4149 929 23118 51295 51701 1950 PMC3601842__F1 mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development 3479 5728 5163 6651 7249 6009 64798 2475 253260 PMC3604893__F1 A) Model of multi-agent vs 613 240 4582 10533 PMC3606787__F8 Significant signaling pathway networks mined from nitroproteomic dataset 85415 5099 394 387 23646 57758 117581 10981 7124 10308 3656 23531 4798 7165 80852 5683 7316 7314 9892 8139 5593 6781 2002 90427 2353 596 10486 51474 9637 11031 83715 7040 29766 11012 5796 2204 6185 PMC3613369__F3 Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines 7431 4312 9965 2253 9590 356 358 5999 1523 9935 5732 948 81035 894 56271 873 51200 4915 23136 6935 22943 5054 10278 2335 PMC3613823__F8 The proposed therapeutic mechanism of caspase-7 ablation in ADRP T17M RHO retinas 6010 2475 22926 468 3091 2157 PMC3614492__F1 Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems 846 6786 50632 90550 PMC3615883__F1 G1 to S phase cell cycle transition regulators.Abbreviations: S, synthesis; G1, Gap 1 4088 4089 993 4609 1021 1019 PMC3616609__F2 The multi-step pathway of CENP-A-containing centromeric chromatin replication utilizing sequential, temporally separated steps across the mammalian cell cycle 324 1017 983 55355 998 1894 PMC3620110__F6 Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß 55723 4171 8318 55388 1026 6790 81620 5218 9212 332 5933 983 9133 3619 5111 4605 993 1063 79968 3398 4616 995 7153 55143 891 5557 PMC3621284__F2 Proposed role of aPKCs in synaptic plasticity: At most CNS synapses, strong synaptic input leads to an activation of PI3K signaling and PDK1 activation thereby (1) thereby leading to mTORC1 activation 5662 4905 5163 1977 1999 PMC3625500__F5 Overview on the mechanisms of glutathione induced cell death 8772 637 581 317 PMC3625980__F7 FBXW7A attenuates inflammatory signalling by downregulating C/EBPD and its target gene Tlr4 7099 4851 2475 PMC3628365__F9 Speculative model of TERRA, hnRNP A1, and hTR/DNA-PKcs interactions at telomeres 3178 23049 5976 PMC3628402__F6 Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence 6426 6241 6240 6125 4193 PMC3629228__F2 De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development 442891 1017 472 545 4609 836 64065 5728 7249 406957 4089 3458 8454 7057 220134 1616 387 10468 4838 PMC3632562__F4 PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects 998 5879 5063 5058 3984 PMC3633488__F3 Decorin’s effects on Beta-catenin and Myc stabilization by directly down-regulating EGFR and Met 4609 1499 1950 4040 4041 5163 57650 4613 PMC3633842__F2 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns 3441 6955 9636 10010 6773 PMC3634798__F1 Stress response pathways 7808 5053 2950 1728 2952 2944 1543 1571 196 5444 2876 847 PMC3635124__F1 Shh signalling pathway1 2737 2736 51684 6608 79659 84976 6469 374654 51098 8100 26160 55081 55764 5727 64399 80199 27152 26005 23770 2619 91653 50937 156 8405 7289 11127 10284 2735 PMC3636761__F1 PI3K signaling pathway and the downstream targets of Akt 5728 5163 2932 7248 7249 595 572 PMC3645655__F3 P53 and BRCA regulation of DNA repair represents a central component of altered cellular function in serous ovarian cancer 5728 4609 5888 472 545 675 672 898 275 5925 2122 4763 8404 114788 57111 7849 51741 3400 120114 PMC3646067__F1 Proposed scheme linking metabolic and signaling pathways to insulin resistance in the heart 6955 948 7038 3667 8660 95 2475 7216 847 PMC3649343__F1 The cholinergic anti-inflammatory pathway depicted 367 324 1103 7124 PMC3650458__F1 Simplified overview of classical bile acid synthesis pathway in mice 1581 1582 6718 PMC3651056__F2 Arachidonic acid metabolic pathways and the role of IL-13 4512 4049 4050 5226 3597 6778 5228 PMC3652284__F1 Regulation of Wnt/Beta-catenin Signaling within and from Osteocytes 6422 50964 4041 4040 324 PMC3652575__F2 Activation pathway of pDCs responding to viral nucleic acids and negative regulation of the pDC function by surface receptors 4615 7189 51284 695 54106 51135 3654 3665 941 942 3569 PMC3653035__F2 Wnt ligands induce diverse Wnt pathways 4040 4041 6010 1499 4131 6259 51176 PMC3654375__F1a Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning 10507 2064 5879 6237 27289 387 PMC3656715__F1 Hippocampal BDNF/TrkB signaling pathways that modulate depressive behavior and antidepressant responses 627 2885 2475 998 387 1499 PMC3656947__F3 PKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells 1263 3569 7124 64332 54101 9258 3037 7127 11182 56999 6793 5970 5966 5971 127544 50486 7461 8797 25816 84002 220 10938 9686 196528 5271 5533 85477 25841 PMC3660836__F6 O-GlcNAcylation in FGF signaling 3343 10724 8473 PMC3661948__F2 Receptor-mediated regulation of KATP channels 3643 3953 4160 PMC3663255__F1 Notch signaling pathway 5045 8650 388585 3280 3516 PMC3668263__F2 LRRK2 regulates cell biological functions important for neurogenesis 120892 324 4040 4041 PMC3669032__F6 Canonical pathway analysis 7124 6774 9261 6420 2 PMC3670293__F4 JAK-STAT pathway in hypertrophic stress signaling and genomic stress response 3976 6774 3717 7008 1025 PMC3670510__F1 Targetable metabolic actors by natural compounds 3099 2597 355 2641 PMC3673714__F2 miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy 1499 5728 7078 PMC3677900__F5 Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells 1950 3082 1956 6774 PMC3678537__F2 Wound Healing in Development 1499 5879 387 324 2932 847 PMC3679038__F7 Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells 8452 7975 2729 9817 PMC3681194__F1 Genes with mutations that cause monogenic, severe T-cell immunodeficiency in humans can be intrinsic to the thymic epithelium or to T cells 5994 5993 8625 6892 6891 3718 100 6023 867 3981 472 5897 1789 3431 7535 PMC3681204__F3 Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines 51191 91543 4938 4939 103 2634 4940 8638 4599 710 114769 9111 3669 10616 834 6891 6737 3627 9636 10964 10410 1890 140691 6890 3437 64108 3434 54739 115361 64135 115362 2633 8651 3665 5610 9447 5371 5359 83666 8743 81030 6772 3433 9246 10346 6773 1241 240 1441 11031 6249 64422 1438 2769 2799 1230 2885 830 10673 3099 81565 5271 8569 1051 2114 604 1052 23643 25801 7305 1147 51296 249 1378 5008 51363 2289 11213 4001 2357 23258 91662 4689 23001 1432 7100 6590 10326 5728 8650 3579 PMC3684428__F1 The adaptive unfolded protein response (UPR) 1998 83939 468 7494 22926 7018 PMC3684428__F2 IRE1Alpha- and PERK-mediated cell death pathways 7186 83939 6957 468 467 596 PMC3687869__F2 Phosphatidylinositol-3-kinase/Akt signaling pathway 5163 5728 572 PMC3688662__F1a MODELS OF INSULIN RESISTANCE AND HEART FAILURE 8660 2308 2475 3667 PMC3689263__F2 Signaling mechanisms important for endocrine resistance and which are currently targeted in clinical trials, combined with aromatase inhibitors 1950 3479 6714 1019 PMC3691765__F1 Apoptotic signaling pathways 355 637 8772 8213 331 790 PMC3698421__F10 Schematic presentation of the Wnt signaling pathway 4040 4041 324 1499 PMC3701138__F1 Main branches ofWnt signalling pathways in neuronal development 4920 6259 4040 4041 1499 1000 6010 PMC3701522__F1 Wnt signalling pathways implicated in diabetic nephropathy 23002 387 324 1499 2932 998 85451 PMC3702532__F8 RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation 2584 5236 4831 7360 2582 2592 3906 124583 PMC3705986__F7 Schematic diagram that describes neuroprotective effects of SUL against ABeta-induced oxidative cell death in AD 1431 9817 581 1728 PMC3707615__F5 Encoding and Decoding Cellular Information through Signaling Dynamics 1950 4803 4804 1956 472 545 4193 7099 467 PMC3708584__F3 ‘ErbB signalling' and ‘TGFB pathway' in the canonical pathway 685 10718 145957 1839 1950 2066 2885 5163 2475 3725 4838 5308 145258 PMC3709125__F1 Gene regulatory networks in mammalian sex determination 6662 6736 100653366 5226 668 2516 1499 2626 23414 5730 84733 4216 2254 2263 54361 50846 1761 268 8876 30812 56603 140689 346673 284654 10468 5225 PMC3710591__F7 Cellular protective response to MeHg through the Keap1-Nrf2 system 9817 8452 4094 PMC3717800__F7 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma 387 7408 3611 5728 673 126669 572 PMC3720596__F1 NRAS mutant melanoma – undrugable? 4893 1029 595 2475 PMC3725129__F1 Proposed BP metabolic pathways and their representative metabolites 8314 10327 1645 1109 PMC3725503__F1 Network of the mechanistic Target of Rapamycin (mTOR) signaling pathway 940 6247 5163 10365 7249 7248 6009 PMC3727154__F1 Immunomodulatory functions of type I interferons 3458 3460 3459 3455 3454 3717 7297 3716 10379 2475 3586 30009 6774 6775 PMC3728701__F1 Musashi1 (Msi1)-dependent activation of Wnt and Notch pathways as well as of proliferation in the intestinal progenitors 8650 10023 1499 324 PMC3731064__F2 Chromatin and the genome integrity network 5932 1763 9156 641 PMC3732055__F1 PAM and Copper – a Gene/Nutrient Interaction Critical to Nervous System Function 5066 1363 475 538 540 PMC3733118__F2 Genes of innate immunity and the biological response to inhaled ozone 7099 960 3569 114609 4615 PMC3734242__F8 Role of PTPA in the Destruction of Periodontal Connective Tissues 3553 6714 4615 8717 5524 7189 7186 PMC3743775__F6 Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling 3661 6774 6772 PMC3750636__F1 USP1 Domain structure and summary of the cellular functions of the USP1/UAF1 complex 2177 55215 7398 56852 5111 324 PMC3751638__F3 METH-regulated genes in METH-pretreated rats 3484 222484 150084 83700 56288 154796 596 6273 26576 3848 5768 22995 7316 55165 6774 11118 5324 81611 26292 3171 10615 3297 10734 245711 1361 5340 3026 5345 4319 3909 2161 650 256933 182 2831 9699 2832 3249 960 9049 1180 1375 5241 8013 PMC3754784__F1 Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis 7100 7099 7096 7097 10333 114609 4615 51311 51284 54106 7098 3654 51135 3663 7189 7187 3665 29110 3661 PMC3755464__F3 Recombination-independent interstrand crosslink repair pathway in vertebrates 7508 199990 51455 PMC3757153__F2 Treatment advances in neonatal neuroprotection and neurointensive care 355 8772 637 317 790 142 PMC3757945__F3 Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair 3480 4485 9113 26524 324 2932 1499 PMC3763401__F1 Crosstalk between COX-2 and EGF signaling pathway in CRC 1950 1956 2885 4512 8195 1236 5226 5228 PMC3763651__F1 Schematic presentation depicting the regulation of receptor signaling through G-proteins 6714 6774 387 PMC3764329__F2 Metabolic pathways for fatty acid and acetate utilization 847 1431 4397 PMC3766629__F6 Immunohistochemical Staining, Laser Capture Microdissection and FASP Assisted Proteomic Analysis of Target Cell Populations within Tissue Samples 7169 7414 7171 3339 721 1191 2752 5232 5284 7360 5339 5962 2335 5906 488 727897 998 9697 800 1277 116 3990 335 23636 826 PMC3770583__F7 Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice 998 5058 595 572 PMC3773342__F9 Proposed signaling process for GDNF-independent UB outgrowth 2668 650 652 4852 PMC3773992__F2 Crosstalk between hedgehog signaling, Wnt/Beta-catenin signaling, notch signaling, and phosphoinositide 3 (PI3)-kinase/Akt pathway and targeting by norcantharidin (NCTD) 6608 5727 283871 4040 4041 324 51684 22943 27122 3714 PMC3778193__F6 Notch1 promotes the pro-osteogenic response of human aortic valve interstitial cells via modulation of ERK1/2 and NFKB activation 4851 7099 650 PMC3779140__F4 Proposed model for TLS pathway 5111 56852 7398 PMC3782367__F1 Unfolded protein response (UPR) is activated in the autosomal dominant retinitis pigmentosa (adRP) retina and proposed to be a target for modulating the rate of retinal degeneration 6010 638 142 22926 7186 83939 2475 468 4901 1406 PMC3783933__F1 IIS/TOR signaling pathway in fat body and the central nervous system of Drosophila 5728 238 7248 7249 6009 PMC3784243__F1 Role of the PD-1 Pathway in the Immune Response 324 940 5728 3558 PMC3786590__F3 Neuroendocrine control of pituitary and gonadal function 23237 3814 84634 2798 2492 PMC3787041__F5 Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques 1234 6358 6348 1232 4077 55801 4283 3082 6036 56832 5919 1106 3105 7019 123 PMC3789264__F5 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) hippocampus (Hp) 51286 55002 213 2597 79026 4155 4082 9118 4137 PMC3801191__F1 Estrogen Regulation of Dkk1 and Wnt/Beta-Catenin Signaling in Neurodegenerative Disease 2932 324 6194 PMC3806867__F5 High-Throughput 3D Screening Reveals Differences in Drug Sensitivities between Culture Models of JIMT1 Breast Cancer Cells 3488 3397 3678 283120 3688 6624 354 2118 3920 2012 4054 1289 10397 961 4851 81029 5106 7431 5327 7078 56937 6876 5728 6678 11031 6590 6286 PMC3807000__F2 Autophagy-related common pathway in neurodevelopmental disorders 5728 7248 7249 4763 2475 PMC3814314__F6 Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish 64399 4838 4852 6678 5308 57216 8312 1856 27130 6597 7547 27022 51176 3371 5664 27123 58158 7022 220202 PMC3814639__F2 Schematic model of the Nrf2–Keap1 signaling pathway 8452 9978 2730 4094 9817 PMC3820524__F1 Overview of hemostasis 7035 324 9015 PMC3820966__F1 Cellular response to oxidative stress mediating by Beta-adrenergic response and sirtuins involvement 1647 581 156 PMC3822617__F3 Multifunctionality of ARC in regulating apoptosis signalling 23237 355 8772 581 637 572 PMC3826519__F7 Deregulated genes upon miR-196a overexpression in keratinocytes 1017 1027 1874 5934 23336 207 1869 7161 4776 351 1871 5925 6610 7124 4684 355 959 6347 3205 8988 PMC3826519__F8 Deregulated genes upon miR-10b overexpression in FaDu cell line 30062 4807 51513 5078 4005 10730 2113 6929 6169 150921 4609 51734 23397 8785 7157 283349 2707 55884 8468 64129 9468 2765 3297 64096 5623 164312 PMC3827157__F4 Transcriptome Analysis of PPARG Target Genes Reveals the Involvement of Lysyl Oxidase in Human Placental Cytotrophoblast Invasion 4015 5054 51129 9429 3480 3638 1803 2180 11343 50650 3162 5468 811 1647 2104 2167 PMC3827948__F6 S4 controls FGF2-mediated signaling through RhoG-dependent macropinocytosis of the FGFR1-S4-FGF2 signaling complex 2247 2260 391 PMC3828821__F1 How does the metabolism of tumour cells differ from that of normal cells 4118 2194 1374 3418 5163 27165 3939 771 768 3099 3098 7054 PMC3833059__F7 Scheme of the proposed LIF signaling pathway in trophoblasts 3976 9021 2885 6774 2475 7018 3977 PMC3835370__F5 Genomic Characterization of the Inherited Bone Marrow Failure Syndromes 4553 6135 6218 6201 6204 6154 6223 6231 6165 54433 6229 55505 55651 6235 51119 PMC3836475__F4 Gene network associated with IFN pathway signaling 2634 115362 3429 94240 129607 3002 353345 6772 162517 6375 3669 7415 10537 55905 8013 3659 3433 10379 3665 64761 54625 3437 931 467 345611 64108 57169 3431 1026 11274 4940 4939 4938 4600 25939 2633 6773 388646 10561 103 64135 7318 4599 29761 684 83666 3959 PMC3839581__F1 Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release 3630 4133 2011 404037 10376 8826 10788 3833 23332 23122 9053 7277 7837 137902 26286 367 3481 1756 7402 23499 667 324 51726 1656 25966 6311 8496 4282 5211 5213 23085 9181 10755 23312 83787 4641 5708 1315 5707 4668 100996569 5327 8455 2695 PMC3841149__F9 WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation 7473 6469 5727 6608 4040 4041 1499 PMC3844392__F1 Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses 5163 664 581 637 467 57103 7249 317 5728 4193 PMC3849657__F1 YAP/TAZ are effectors of mechanical stress, GPCR signaling, and the Wnt signaling pathway. Mechanisms of YAP and TAZ regulation by mechanical stress, GPCR signaling, and the Wnt pathway as well as YAP/TAZ as modulators of the Wnt pathway are shown 4018 6010 4485 1499 9113 26524 7525 6910 6657 374 332 430 598 PMC3851544__F6 MT1G as a tumor suppressor in thyroid cancer cells through regulating the PI3K/Akt and Rb/E2F pathways.MT1G restoration inhibited phosphorylation of Akt, leading to inhibition of cell growth 4495 4193 999 PMC3857727__F3 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors 2289 4280 2932 23057 PMC3858246__F1 Canonical WNT/Beta-catenin signaling and inhibitors 324 1499 3952 PMC3864108__F1 Schematic diagram showing the interaction between NW arenaviruses and host innate immune response 7097 7096 10333 4118 7187 29110 3661 4615 PMC3865646__F2 Apoptosis by hypothermia 841 836 842 PMC3865866__F8 The FBXL2- and PTPL1-dependent regulation of the PI(3)K pathway 25827 3667 5728 5163 PMC3867791__F6 Regulated in DNA Damage and Development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1) 83939 468 7249 7248 8408 PMC3870464__F2 Protein components of the pheromone response network constructed by the PCST approach 116985 991 7018 3630 59272 110740339 1233 PMC3880276__F9 Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2 55615 64798 5163 7249 9776 PMC3883113__F6 Neurodegenerative diseases and widespread aggregation are associated with supersaturated proteins 351 23385 3416 4023 348 572 841 637 8772 355 842 836 317 6622 4948 100506742 22926 7124 1020 2932 840 PMC3891052__F3 Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome 7124 340419 5796 1956 355 8323 4763 2778 5770 4771 7186 8772 6047 4893 3265 3845 5723 7046 5921 673 5900 5584 5728 324 2475 150094 581 387 2308 6146 6469 51684 6608 898 3122 676 4193 8453 7428 54880 8405 861 2625 2033 1896 6714 10051 545 4149 8295 4609 1108 PMC3895844__F2 Ephrin receptor signalling is the most significant canonical pathway in an olanzapine-treated cerebellum 5829 2534 759 1950 3717 8997 387 6774 1398 PMC3896120__F8 Schematic diagram of EGFR-invadopodia signaling pathways altered by Abl inhibition in HNSCC 1839 6714 1956 PMC3897272__F1 Eicosanoid biosynthetic pathway 1956 4513 4512 717 4015 8644 5730 PMC3900522__F3 Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFBeta-Activated Kinase 1 Tyrosine Phosphorylation and NFKB Signaling in Multiple Myeloma and Bladder Cancer 7003 25805 84268 7316 57026 8517 2180 6340 11074 408 7763 6446 6565 10991 8000 11320 PMC3901146__F1 Regulation of cellular stress-induced cell death pathways by IAPs 6611 331 8772 842 4671 836 PMC3901146__F3 Role of IAPs in DNA damage response 8772 331 7189 472 23118 4193 PMC3905242__F4 MRE11 complex: starting from the ends 3981 4361 472 637 10111 3014 PMC3910515__F7 TGFB signaling at the BBB during acute peripheral inflammatory pain 7040 4087 4088 4086 4090 4089 PMC3913083__F1 Signaling pathways involved in the control of skeletal muscle atrophy and hypertrophy 10220 3479 238 3667 4088 4087 2475 1386 8665 9759 PMC3919687__F5 Kinetic changes in gene expression of selected components of the Wnt/Beta-catenin signaling pathway in aging CD8+ T cells 80326 27120 6608 4040 4041 324 1499 2932 51176 6932 920 PMC3928598__F1 Protein O-linked ß-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function 2973 6675 8473 10724 PMC3930904__F1 Global view on the intracellular proteome profile change in P 2203 7167 5230 2023 316 48 4190 PMC3931732__F9 CHC-1 and EPN-1 promote actin polymerization in response to CED-1 signaling 29924 84466 84465 PMC3934873__F1 Iron Transport Machinery of Human Cells: Players and Their Interactions 7018 55240 3240 9332 PMC3940969__F2 TLR signaling pathways in cerebral IT 4049 54106 51284 7096 7097 10333 7099 4615 114609 51135 7189 3654 3661 3665 PMC3941170__F2 Cell cycle regulation by p16Ink4b/p14ARF 4193 1021 1019 PMC3941198__F1 Milk lipid secretion: recent biomolecular aspects 4018 123 8694 137964 PMC3942330__F8 Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms 382 6714 375 999 10139 8729 PMC3943605__F4 GENETICS AND EPIGENETICS OF ADRENOCORTICAL TUMORS 4041 4040 324 PMC3943767__F3 Proteolytic pathway that controls glucose uptake in fat and muscle 3667 208 9882 23216 5412 PMC3944192__F1 Kidney Regeneration: Common Themes From the Embryo to the Adult 5076 7849 650 652 655 7484 7481 6299 3975 54361 7477 PMC3946676__F1 Changing appetites: The adaptive advantages of fuel choice 355 3417 26227 3418 2744 545 PMC3946959__F1 Proposed signaling pathway for PCB detoxification in vivo 2936 196 1543 57716 PMC3947439__F1 Molecular pathways regulated by PGE2 that are inhibited by aspirin 1956 6714 2932 324 2475 1499 6925 PMC3954635__F4 Beta-catenin pathway 1499 6607 6606 1012 6623 1755 309 6869 2294 324 5281 124245 5581 10318 2175 5091 4087 56923 3094 596 5521 3909 PMC3954825__F2 DISC1 as a key lead in studying cortical development and associated brain disorders 3084 2065 2064 324 27185 2932 1499 7018 1600 351 7436 PMC3956974__F3 Signaling control of CAR activation 1950 1956 5225 23426 1958 PMC3961947__F1 Molecular pathways altered by green tea extract 3479 3486 4133 596 PMC3964949__F3 Motif-mediated interactions annotated in the ELM resource mapped onto the KEGG () human Phosphatidylinositol-3′-kinase-(PI3K)–Akt signaling pathway (hsa04151) 2475 1977 7248 6009 7249 7099 613 6850 5934 759 5728 572 4193 PMC3970768__F1 The biotin cycle and the known and putative roles 4163 5091 847 PMC3973216__F4 Simplified representation of the regulation of actin cytoskeleton pathway and differentially regulated genes 2254 2149 23596 6002 5266 998 1999 24137 PMC3975884__F1 EGFR associated signaling pathways in lung cancer 1950 1956 3845 6714 6009 2475 PMC3978568__F1 Schematic representation and overview of PTEN/PI3K/AKT signaling and a model of the mechanism of peroxisome proliferator-activated receptor (PPAR) action 5728 7249 7248 2475 1499 PMC3983496__F2 The proposed intracellular signaling pathways regulated by Cx43 hemichannels in bone cells 51665 6714 572 1499 5741 PMC3983720__F8 Diagram of putative mDA differentiation pathway based on this and other studies 4090 4086 6469 7481 3170 7054 5309 4009 PMC3984709__F9 Schematic diagram of the proposed interface between mechanostimulation and biological signaling at acupoint 24145 7442 100188011 PMC3990718__F9 Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis 727 3553 114548 718 57506 3661 PMC3991464__F1 Four pathways of androgen metabolism 1646 1586 8644 PMC3995130__F2 mTOR Signaling in Cardiac Physiology and Disease 7249 7248 6009 64798 PMC3995556__F9 BTC-stimulated IL-8 production and bio-behaviors of lung cancer cells 685 1956 2885 2475 2002 PMC3997659__F1 Role of Ub and SUMO modification of PCNA 5111 56852 118027463 51455 27343 PMC3998024__F2 Top-ranked gene network 23001 9474 9590 5265 6037 85480 3636 200734 6351 7444 10906 613 7187 4049 3447 83953 939 378 PMC4001311__F6 Schematics of the regulation of the HMOX1 expression under normal (a and b) and stress conditions (c and d) and without (a and c) or with (b and d) BRD4 knockdown 23476 9817 8452 6667 4599 PMC4001324__F1 Simplified overview of the receptor tyrosine kinase (RTK)-RAS and RAS-related RHEB signaling pathways 367 8036 4763 6009 5728 867 6654 2475 PMC4003878__F2 GSK3B and the control of infectious bacterial diseases 3718 2932 1499 7124 PMC4007103__F2 Biogenesis of Drosophila small regulatory RNAs 29102 26523 27161 192669 PMC4012993__F6 Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation 54361 7474 7476 11197 27122 6423 8321 6714 10023 3611 10000 208 2149 324 1499 2932 8313 6660 5914 26060 55824 3725 5467 595 6925 PMC4013580__F6 A schematic model presenting the pathway of BMP4 to affect foam cell formation 659 4090 4086 19 9619 652 PMC4018451__F1 The IRS-1→PI3K→Akt insulin signaling pathway 5728 5163 3667 5164 207 7249 572 2309 PMC4018451__F2 Schematic summary of hippocampal formation alterations in the IR→IRS-1→PI3K→Akt→mTOR signaling pathway of AD dementia cases versus age- and gender-matched controls 5728 5163 3667 5164 7249 7248 2475 2931 PMC4019409__F2 Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease 5879 27035 124056 6098 22933 8772 8717 PMC4020326__F2 Glucogen‐like peptide‐1 and cancer 3479 3481 3486 3480 PMC4021685__F1 Schematic simplified demonstration of the main mechanisms supposed to be involved in fatty acid and TNF family interaction at different levels of colon epithelial cell organisation 3458 7124 8717 8772 7186 4015 637 PMC4022041__F3 Genes involved in the TGF beta signaling pathway after 5 days 4089 9978 8454 7057 4087 4088 387 4838 PMC4022110__F1 Schematic overview of MBL-dependent activation of the lectin pathway of complement 717 720 721 718 727 729 PMC4023229__F2 Neural tube defects – recent advances, unsolved questions and controversies 7474 115908 6422 6425 6423 81839 57216 5754 22881 64750 57154 387 PMC4023701__F5 Crosstalk pathway 710 1191 5649 51365 6863 2006 4653 629 6423 3075 3910 7422 6347 6678 6586 5196 6696 9636 255738 1277 2252 3371 7077 183 9353 3976 975 1511 3672 57722 6401 8434 6383 4311 2264 4920 800 9672 PMC4023801__F2 Proposed metabolic activation pathway of GS-6620 1066 3094 8824 PMC4026364__F1 Tumor Suppressor p53 and Estrogen Receptors in Nuclear–Mitochondrial Communication 4193 57103 9997 7019 PMC4026741__F1 Pattern recognition receptors in respiratory anti-viral immunity 7808 7098 6714 7189 7297 3716 3661 3725 2353 PMC4028717__F7 Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway 637 581 8772 PMC4030113__F2 Abnormalities in IRS1 interaction in the KEGG PI3K-AKT signaling pathway (PI3K-AKT) 54541 2475 7249 6194 4846 3265 4133 2885 5515 3667 5516 6850 4609 930 1440 1441 5747 11140 5934 5728 356 200186 572 596 842 10681 10488 6256 1147 4193 PMC4030113__F3 Abnormalities in IRS1 interaction in the KEGG Oxidative Phosphorylation metabolic pathway 4519 4536 4537 4538 4539 4541 4722 4720 126328 4705 55967 51079 4701 4706 4718 4716 4710 4713 4708 6389 6390 6391 6392 1352 1349 4513 4514 10063 1355 3667 7454 PMC4030640__F2 Molecular and biophysical characterization of the human blood-nerve barrier: Current concepts 2668 2674 5979 1499 1003 PMC4032603__F3 KIBRA in Hippo pathway 122786 4771 154796 11113 4485 26524 PMC4040287__F4 SIRT1 in neurodevelopment and brain senescence 627 3297 6093 23411 102 5915 PMC4045475__F1 MUC1: A Novel Metabolic Master Regulator 4582 7249 7248 57103 4193 5163 2195 948 27165 6510 PMC4045475__F3 MUC1: A Novel Metabolic Master Regulator 4582 2876 2539 6647 3939 27165 6510 948 2195 PMC4046519__F4 Network analysis performed on converging genes differentially regulated in response to different stresses in mouse and between different selected Flinders lines 26137 7267 3645 7078 55611 23524 5764 9584 7280 23237 91807 79739 347688 6844 2009 PMC4046670__F6 Prioritized genes in apoptosis and TNFR2 signaling pathways 355 6955 572 PMC4049637__F1 Functional Conservation of Coenzyme Q Biosynthetic Genes among Yeasts, Plants, and Humans 27235 51805 51004 5538 10229 84274 51117 57017 PMC4051344__F1A Regulation of Inflammation in Cancer by Eicosanoids 4015 4512 4049 4050 5226 PMC4051845__F1 DNA double-strand break repair pathway choice and cancer 55183 580 672 PMC4054791__F1 Schematic representation of the photorespiratory pathway (in black) and the three circumvent pathways designed to overcome the photorespiratory losses 718 717 727 PMC4059167__F1 Canonical catecholaminergic neuron is one that generates dopamine, noradrenaline or adrenaline 7054 1621 5409 PMC4060729__F2 Flowchart showing the induction of ER stress and its physiological outcomes during coronavirus infection 22926 83939 7494 PMC4061161__F1 The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment 3082 6714 2549 1398 2885 1399 6774 2475 6010 PMC4066335__F3 All diabetes drugs are likely to have indirect effects in the CNS by affecting circulating concentrations of glucose and insulin 3667 6774 5163 PMC4067916__F1 The Hippo pathway in mammals 122786 4485 60485 9113 26524 2736 374 PMC4074570__F3 Regulation of receptor-mediated endocytosis by CRL pathways 338376 8454 6500 9978 8452 3454 PMC4075038__F3 Signal Transduction in Vasculogenesis and Developmental Angiogenesis 6714 8826 6461 998 51564 PMC4075129__F1 PI3K/AKT/GSK-3B signaling pathway in neuronal cells of Alzheimer’s disease 627 2932 1020 PMC4075129__F3 Molecular targets based on the predominant PI3K/AKT/GSK-3B pathway 627 2932 1499 PMC4075482__F5 Pathway Analysis 226 1737 4967 23530 4698 3418 4723 PMC4076843__F2 Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders 196 405 1543 PMC4076960__F8 Muscle hypertrophy and atrophy 2660 2247 3479 3082 10468 93 3480 207 1432 5599 5594 5163 801 5530 57521 4772 1977 2475 4656 4617 2932 4654 84676 4618 1026 114907 PMC4082998__F1 Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes 53822 6714 1956 PMC4085163__F6 Schematic models of signalling pathways used by SDF-1/CXCR4 and GLP-1/GLP-1R in the activation of beta catenin/TCF7L2-mediated transcriptional expression of genes involved in beta cell survival and proliferation a SDF-1 activation of WNT signalling 7852 324 6934 PMC4090452__F2 Integration of the proposed pathways by which the NTPDase5/mt-PCPH acts on the neoplastic progression 5728 2475 100303716 PMC4091980__F1 Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain 4193 572 842 2475 5728 PMC4099115__F3 Metscape gene-compounds metabolic network views of top IPA canonical pathway and biological function/disease 4553 5436 8732 10621 5440 5433 55703 5435 51728 64425 5431 54956 4837 57097 142 10039 64761 8658 80351 10038 143 25976 54625 683 84875 420 419 116969 PMC4100111__F3 Bioinformatics analysis by String 10549 5021 3856 3875 1358 1504 55666 7415 5646 1360 23549 80700 7184 5223 5230 25796 60314 PMC4103865__F2 Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming 3643 2353 355 572 1938 PMC4104512__F4 Functional zonation of the rat adrenal cortex: the development and maintenance 1583 1584 1585 51663 PMC4104784__F5 RNA-seq upregulation of energy metabolism gene expression 100 5160 1431 50 7167 2597 4190 5230 6391 4729 8803 7385 2023 7384 PMC4112277__F1 The PPP and glycolysis is shown 2539 7086 6888 3939 PMC4114189__F1 Molecular pathway of the mechano-induction of tenascin-C 4118 6722 387 6010 3611 PMC4115244__F3 Pak Signaling in the Development and Progression of Cancer 998 572 387 4609 PMC4115639__F4 Cartoon depicts IL-15 mediated activation of the PI3K/ERK1/2 and JAK1/STAT3 pathways 3716 6774 3601 3560 PMC4122622__F1 Crosstalk of BMP and neurotrophin signaling in neurons 57154 1848 2002 6722 5163 PMC4126409__F1 Pathways for HJ Resolution(A) Resolvases RuvC and GEN1 digest HJs to generate linear products with single nicks (carets) 348654 80198 84464 146956 PMC4127075__F2 Regulation of EMT by KLF4 in Gastrointestinal Cancer 1950 182 1956 4853 4851 4087 4088 4089 6774 1499 2475 9314 1000 999 PMC4128657__F5 An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients 8737 2994 3661 10379 1386 3725 9636 PMC4129373__F1 Schematic cartoon of TLR signaling pathways 7096 7097 10333 7099 7100 81793 3929 4118 4615 929 7098 3663 51284 51311 7189 7187 54106 29110 3661 3665 948 PMC4130654__F1 PI3K-PTEN-mTOR pathway 5728 5163 5164 7248 7249 6009 64798 5879 6010 6446 PMC4131144__F5 Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model 619501 3099 5226 5634 5207 2820 31 3939 38 47 5163 5164 4199 48 50 4190 3417 3418 2746 2747 2271 4967 6389 PMC4133204__F10 Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NFKB Signaling Pathway 6774 4313 4318 PMC4133236__F12 CXCL12 Induces Connective Tissue Growth Factor Expression in Human Lung Fibroblasts through the Rac1/ERK, JNK, and AP-1 Pathways 6387 7852 5879 PMC4139479__F6 A Novel Mechanism of Skin Tumor Promotion Involving Interferon-gamma (IFNG)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling 3458 3459 3716 PMC4140952__F1 CPAcP interaction with HER-2 and PI3K/Akt pathway in regulating prostate cell homeostasis 5163 367 572 PMC4140976__F1 Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging 2885 26060 5163 7248 572 7249 6009 2475 8408 2887 PMC4140976__F2 Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging 3479 3480 3667 8660 PMC4147234__F2 MTOR pathway in T cells 940 3558 253260 3611 7248 6009 50943 PMC4148637__F1 Relationship between PI3-K–Akt–mTOR signaling and autophagy in muscular dystrophy 2309 7249 6009 9140 664 PMC4158839__F2 The development of the auditory sense organ 23493 10253 2253 6657 57216 7976 1856 PMC4163376__F2 Simplified overview of the Rb/E2F pathway 4173 4176 4172 4171 4174 4175 PMC4166552__F9 Model of cooperation of PLCB3 in the P.aeruginosa-dependent signaling in bronchial epithelial cells 7097 5331 7100 4615 PMC4168797__F7 Paraquat hijacks the PPP to induce oxidative stress and cell death 2539 5226 2821 7086 2597 5230 2805 2744 4967 PMC4169143__F1 Back to the Future: Oral targeted therapy for RA and other autoimmune diseases 2885 3716 126669 5163 7249 7248 6009 64223 2475 PMC4169646__F7 Prolyl-Hydroxylase Inhibitor, Ethyl-3,4-Dihydroxybenzoate, Induces Cell Autophagy and Apoptosis in Esophageal Squamous Cell Carcinoma Cells via Up-Regulation of BNIP3 and N-myc Downstream-Regulated Gene-1 581 664 10397 596 PMC4171604__F8 Anti-neoplastic properties of hydralazine in prostate cancer 1950 1956 6714 PMC4172968__F11 Schematic representation of the signaling pathway proposed for the AhR-dependent control of cell migration 857 196 6714 1445 PMC4175047__F9 Proposed mechanisms by which miR-34a regulates mesangial cell proliferation 5159 595 1021 1019 1017 PMC4176998__F9 Schematic diagram demonstrating speculated roles of ER stress signaling pathways in diabetic cardiomyopathy. Firstly, under pathological condition of hyperglycemia in myocytes, ROS is generated by glucose oxidation in mitochondria 22926 83939 7186 468 PMC4187614__F2 Rho GTPase signaling pathways regulating neuronal survival 6010 5728 572 581 PMC4188627__F3 Methamphetamine Alters the Normal Progression by Inducing Cell Cycle Arrest in Astrocytes 5885 4199 7851 699 9184 1017 23632 1311 1763 5111 PMC4190013__F1 Signal transduction pathway for type I IFNs and a summary of key ISG effects on the virus and mucosal immune response during influenza 3455 7297 6773 10379 3665 3627 6041 6035 PMC4200202__F7 Simplified interaction map between the LOXL4 protein with the OS pathway by both protein-protein interaction analysis and literature mining 84171 11140 1280 780 650 7040 3490 2335 5310 4899 23411 54536 6839 51295 PMC4201594__F6a FOXO3-mTOR Metabolic Cooperation in the Regulation of Erythroid Cell Maturation and Homeostasis 3098 226 2597 5230 3418 3417 5223 5163 3939 3945 PMC4202134__F7 Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk 355 4193 572 5728 581 8772 637 PMC4207610__F7 HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst 1045 6657 79923 2249 2627 PMC4209203__F10 Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia 23512 2146 8726 3720 6418 55294 23133 4851 9794 PMC4211323__F1 Possible roles of Hsp90 in AD 7099 2011 1020 PMC4211543__F1 PrPCsignaling via SFKs 23621 4155 1499 999 2534 6714 1956 PMC4219296__F1 Wnt signaling pathway 4040 4041 6259 4920 2932 324 1499 999 607 595 4316 51701 PMC4224557__F8 Postulated molecular regulation of eukaryotic elongation factor-2 kinase (eEF-2K)/TG2 pathway to the invasion-promoting signalling in pancreatic cancer (PaCa) cells 6714 6935 999 PMC4225461__F1 Statistically significant signaling pathway networks between JU and vehicle groups 10870 634 161742 27329 390 2354 3680 186 5420 6097 467 1081 1846 268 4519 27000 5055 5702 6041 100188773 306 7157 5737 83464 900 9546 55851 1356 1616 56897 PMC4227529__F1 Metabolic shifts through the hexosamine biosynthesis pathway (HBP) and protein O-GlcNAcylation in cancer 3845 8473 10724 PMC4243732__F1 Cyclooxygenase and 5-lipoxygenase pathways with special reference to aspirin exacerbated respiratory disease 4512 4049 2840 PMC4245912__F2 The secretory pathways used by NMDARs 10755 8573 547 57576 PMC4252505__F3 Hras-Braf MAP-Kinase pathway visualized using GenMAPP software 5331 22821 6494 4893 5909 6237 3845 4214 10746 4215 7786 5894 369 673 1637 5604 5605 5609 5595 5594 2002 6416 4155 5602 3725 PMC4252583__F3 HDL and Cognition in Neurodegenerative Disorders 335 3931 19 PMC4254557__F8 Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling 2925 2922 83737 11270 PMC4259987__F2 Pathway analysis (STRING v9.05) of 39 proteins significantly dysregulated in the CSF of subjects with mild or moderate delirium relative to the mild AD control with no delirium 5653 3273 4045 1191 1471 63827 2934 348 183 350 1113 347 4897 1114 351 29106 335 3240 3039 4684 3043 2243 1475 336 7123 5176 3490 PMC4260746__F4 Caspase-1 activation by inflammasomes leads to pro-inflammatory cytokine production: Inflammasomes can be triggered by various stimuli 114609 4615 114548 22861 58484 3146 3553 PMC4261510__F2 Hippo signaling pathway 4771 60485 4485 PMC4261550__F1 Neuroprotective functions of resveratrol in AD pathogenesis 581 50507 2876 6772 6774 PMC4263734__F5 Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells 51701 80319 100126334 324 8323 51176 4089 4088 9350 27123 6477 6500 8454 9978 PMC4264417__F1 HER receptor and pathway: (A) there are four members of the HER family of RTKs: EGFR/HER1, HER2, 3, and 4 1956 1950 5728 6009 64798 5164 8726 PMC4264417__F2 Notch receptor and pathway 1950 28514 4855 4851 4854 4853 9794 23462 1636 PMC4264417__F4 Notch–HER2 crosstalk in HER2+ BC (A) 3273 1950 331 182 PMC4267164__F1 TLRs signaling 7100 7099 7097 10333 7096 51135 114609 7189 4615 7187 23118 10454 29110 3665 3661 PMC4267804__F6 RNA-Seq Analysis of Equine Conceptus Transcripts during Embryo Fixation and Capsule Disappearance 6714 5340 842 572 PMC4270317__F5 Cell cycle pathway 2153 7851 699 9184 1022 1017 2191 PMC4273559__F2 KEGG pathways significantly associated with NPG 775 100137049 8681 1892 224 27091 27092 6654 622 2534 5881 3157 5578 1962 5162 2122 7867 929 4208 10912 54361 7479 2805 2132 7475 80326 655 64131 64399 PMC4273559__F3 Butanonate metabolic pathway (KEGG pathway hsa00650) 7915 79944 18 5161 5160 5162 2571 2572 341392 6296 116285 123876 54988 348158 35 219 217 224 223 501 1892 1962 3030 3033 622 56898 65985 38 39 3158 3157 5019 64064 3155 PMC4274867__F1 KEGG pathway of 470 DEGs downregulated in the frontal cortex of AD identified by RNA-Seq data analysis 2693 799 5724 2696 4158 2834 2642 2862 2492 3973 4018 7253 27201 6344 2925 1241 5021 2690 3952 3953 6865 5617 5618 PMC4277354__F6 ReNE: A Cytoscape Plugin for Regulatory Network Enhancement 100187761 6955 1603 27429 6389 2774 54205 842 5566 1385 3172 10105 3297 2099 5978 1813 1812 11315 9627 65018 2770 PMC4278301__F1 Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans 5091 26191 51573 2166 27163 PMC4278302__F6 Acellular fraction of ovarian cancer ascites induce apoptosis by activating JNK and inducing BRCA1, Fas and FasL expression in ovarian cancer cells 672 355 1616 2597 PMC4280296__F1 Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement 4397 4548 875 PMC4283829__F9 Key role of transient receptor potential melastatin-2 channels in amyloid-Beta-induced neurovascular dysfunction 948 7226 8505 PMC4284387__F2 MiR-124 and miR-9/9* engage in complex regulatory circuits activating a neuronal gene expression program 5978 5725 58155 3280 PMC4287361__F1 Epstein-Barr virus Associated B-cell lymphomas: Pathogenesis and Clinical Outcomes 864 4193 595 1017 1021 8717 3383 6850 4067 PMC4296672__F7 Estrogen Receptor-alpha 36 Mediates the Anti-apoptotic Effect of Estradiol in Triple Negative Breast Cancer Cells via a Membrane-Associated Mechanism 4018 1902 23566 5091 PMC4298325__F6 A, Diagram of the prostaglandin synthesis pathway including relative expression values (arbitrary units) for synthetic enzymes and receptors from our previously reported microarray analysis of bovine growth plate chondrocytes () 4512 5228 5226 PMC4299486__F2 Endocrine system development and function 56670 646 10887 55890 51129 9068 3861 25924 139760 9290 623 7224 50856 80835 PMC4300866__F2 Three pathways of complement activation: classical, lectin, and alternative pathways 721 720 718 727 716 730 729 5648 10747 717 PMC4302085__F1 Networking of the PI3K/Akt/mTOR signaling pathway 1950 1956 3480 5163 5728 2475 4193 6009 595 253260 PMC4304911__F3 Regulation of protein synthesis through the mTOR signaling pathway by amino acids and insulin 3667 7249 7248 5163 2475 1977 PMC4305100__F3 Interaction of HBV and TLR2/4 7097 51135 3654 4615 7189 3656 PMC4306190__F4 Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview 3146 6285 7412 PMC4311405__F5 Deregulation of signaling pathways and transcription factors 3105 3106 567 1956 2261 2064 2260 3480 4055 8452 329 9817 8772 5728 841 7187 4780 595 1029 2195 1021 8626 1499 84962 4609 1869 5925 7157 PMC4316382__F2a BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells 6608 1894 55733 6657 4319 PMC4320218__F1 PI3K/Akt/mTOR signaling pathway 3479 6009 7248 8408 PMC4324555__F5 CREB and the CRTC co-activators: sensors for hormonal and metabolic signals 23235 200186 6874 PMC4325379__F1 An overview of melanocyte development 1638 3815 4286 7306 6663 PMC4329227__F2 Pentose phosphate pathway and cancer 472 6714 7086 6120 57103 2475 4609 PMC4339020__F1 TNFA in Cerebral Ischemia: Another Stroke Against You? 8717 8772 637 841 581 PMC4339202__F6 Metabolic and Chaperone Gene Loss Marks the Origin of Animals: Evidence for Hsp104 and Hsp78 Chaperones Sharing Mitochondrial Enzymes as Clients 1130 84706 95 PMC4339613__F3 Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment 7428 4094 9817 PMC4346003__F5 Gene network, created using IPA® software, reflecting EGCG treatment.Notes: The overexpressed genes are labeled in red, while those downregulated are marked in green.Abbreviations: EGCG, epigallocatechin-3-gallate; IPA, Ingenuity®Pathway Analysis 7157 6935 4609 355 7481 9049 PMC4346193__F5 Schematic model illustrating how IGFBP-3 proteins regulate the TNFA and apoptosis pathway in REC: Right 3486 7124 7078 4035 PMC4346882__F3 Schematic depiction and overview of PI3K/AKT/PTEN signaling has been shown 5728 7249 7248 2475 1499 PMC4348434__F2 Oxidative Krebs cycle 2744 1376 1431 5091 PMC4355290__F5 Changes in Protein Expression in Two Cholangiocarcinoma Cell Lines Undergoing Formation of Multicellular Tumor Spheroids In Vitro 3305 6649 5268 213 613 7430 10525 811 7184 3880 7431 3872 2597 3329 5034 PMC4359534__F7 Cardiovascular disease, lipid metabolism, molecular transport 2012 1908 2173 1622 3638 651 1071 9388 PMC4359534__F8 Cell-cell signaling and interaction, molecular transport, small molecular biochemistry 153 7352 4922 70 4009 4703 4739 4088 313 PMC4359534__F9 Lipid metabolism, molecular transport, small molecule biochemistry 1394 1395 8029 136319 2627 2354 796 81693 4632 3357 PMC4362662__F7 A hypothetical illustration for the mechanism of resveratrol on the EMT of colorectal cancer 4088 4087 999 PMC4365363__F3 The major TNFR1-mediated signaling pathways 7124 8717 7186 23118 257397 197259 8772 3550 PMC4365929__F3 Ultraviolet B (UVB)-induced cell cycle signaling and the relationship between p53 and phospho-Chk1 (Ser317) 545 891 983 PMC4366044__F4 Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics 387 10125 399 3683 8139 7408 5810 3676 4948 5829 1398 PMC4366240__F4 Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 5595 8445 2874 9748 5111 2934 581 51499 4839 51741 9627 1452 3190 7534 23041 8575 7157 3308 2013 373 10919 4831 2778 10445 2130 5621 4193 PMC4367534__F1 DNA double strand break (DSBs) repair 4361 10111 1763 6117 9156 6118 5888 672 675 641 PMC4367534__F2 Regulators of HR repair as potential therapeutic targets 472 545 983 675 641 27316 5888 5347 988 1263 1956 672 3480 3667 PMC4369672__F1 Intracellular signaling proposed to be involved in the inflammatory response during immune-mediated joint diseases such as aseptic loosening 51428 3428 54106 4615 29110 3661 3665 51135 3654 7189 10392 64127 114609 10333 7096 7097 7100 3146 6279 6280 3553 3456 90865 PMC4369962__F4 Calcium signaling pathway in old nitrate treated aorta 90550 5350 3371 857 858 859 613 952 PMC4372177__F5 Top Kegg pathways enriched with aDMCs identified by the FatiGO analysis 1896 3280 619410 3630 790 1363 920 6927 3171 3458 PMC4377623__F2 Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis 5182 51056 5184 5185 PMC4383015__F5 Foxp3-biding genes in ‘pathway in cancer’ 6608 7428 51637 PMC4383151__F1 Metformin action to inhibit cancer 6714 6794 2475 PMC4384696__F5 Indoleamine 2,3-dioxygenase pathways of pathgenic inflammation and immune escape in cancer 2475 4553 1998 PMC4391134__F7 Diagram of potential APOE4 -induced decrease in synapse-related proteins and disruption of NMDAR-mediated signaling, resulting in impaired learning and memory 348 2312 9896 338 627 55137 PMC4392244__F9 Comparing CGN death induced by NSC23766 and ToxB 6010 998 7074 7204 5062 5063 5058 572 PMC4398509__F1 Working model for pathway for bacterial lipoic acid metabolism and its possible regulation 3989 3988 1401 PMC4398619__F5 Diagram of EGFR signaling pathway showing impact of gefitinib and erlotinib on EGFR downstream signaling proteins 6714 867 6774 2885 PMC4400383__F3 Insulin binding causes activation of the insulin receptor (IR), which phosphorylates different substrate adaptors such as the insulin receptor substrate (IRS) 5728 5163 208 7249 6009 1977 2549 PMC4401125__F1a HSPs regulatory function in the intrinsic (A), extrinsic and caspase independent pathways to death (B) 581 572 790 2623 PMC4403556__F1 miR-137 Intersection Target Network of Neurological Disease 998 6714 3815 6558 4851 5743 1112 775 7082 5925 1017 23435 84867 7020 8932 12 3064 9314 2554 4905 1690 54557 4763 1847 4665 2779 PMC4403556__F2 miR-137 targets within Protein Kinase A (PKA) Signaling Pathway 6608 4804 1630 4088 5743 4089 387 2737 1385 5594 5595 572 7408 5350 6925 2002 11101 10148 PMC4403665__F1 Chemotherapeutic Targeting of the Transforming Growth FactorB Pathway in Breast Cancers 4088 2475 4087 4089 6714 PMC4404599__F3 Schematic overview of some of the most significant IPA-identified, canonical host response pathways 6772 6773 7706 3665 3661 3550 10379 3434 3430 684 3579 3577 958 7189 6891 6890 811 7412 3383 6347 PMC4406847__F4 ROS are important contributor to renal injury and inflammation 10628 114548 3553 PMC4408933__F3 Adipocytokine signaling pathway as represented in the Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/kegg1.html) (; , ) 2475 8717 7186 9021 3953 6774 181 4852 5465 PMC4409326__F2 MicroRNAs in the pathogenesis of cystic kidney disease 29102 54487 100187761 PMC4409470__F2 Nutrients, Foods, and Colorectal Cancer Prevention 5741 3630 7421 759 4513 581 PMC4409526__F4 Diagram depicting molecules involved in actin cytoskeletal regulation mediated by NMDA signaling pathways and having altered mRNA expression in bipolar disorder 88 5501 8874 4983 5578 8997 84687 55607 5879 998 387 8476 6093 5217 11034 1072 1627 PMC4410070__F1 Accelerated Vascular Disease in Systemic Lupus Erythematosus: Role of Macrophage 4282 7412 3383 PMC4412274__F2 Mechanical forces influence growth rate 474168 4485 9113 PMC4413642__F6 Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/Beta-catenin pathway 9353 999 6091 1499 6714 595 PMC4414490__F1 Activation and Function of Small GTPases Rho, Rac, and Cdc42 During Gastrulation 5879 387 23002 998 PMC4415242__F8 The three axes of the UPR in Drosophila brains activated by HTorAΔE 22926 83939 7494 468 PMC4421076__F6 Sustained Interleukin-1B Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids 3603 5310 581 3484 1843 3394 3553 3554 PMC4421107__F1 Energetic and biosynthetic functions of de novo lipogenesis (DNL) in the control of metabolic homeostasis 355 47 23152 PMC4425062__F6 Theoretical model of the negative regulation of the PA signal pathway by myostatin in skeletal muscle 2660 84812 2475 PMC4425997__F1 The fundamental aspects of the DNA damage response pathway 545 472 581 637 675 PMC4426903__F3 Evolutionary Changes in Promoter and Enhancer Activity During Human Corticogenesis 1956 2303 1305 6909 6913 1278 652 2200 7049 10516 1277 22795 89932 6778 2022 2199 1282 1003 4811 80781 9096 9580 1306 4090 4086 4089 4092 4091 1950 6667 4087 4088 4838 PMC4427070__F12 Summary of the three-way interaction among AMPK, SIRT1, and eNOS.Notes: AMPK and SIRT1 exhibit a bidirectional interaction in response to cellular energy status and regulate lipid metabolism and inflammatory status 23411 5465 355 3569 PMC4427128__F1 Coagulation and inflammatory response activation during dengue 3383 7018 958 3603 6347 7035 PMC4433473__F3 Ligand-dependent LRP6 endocytosis 4040 4041 22943 1499 6925 PMC4435618__F1 Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans 2885 8660 2932 PMC4435618__F2 Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans 2885 2475 1978 7249 7248 1977 2309 664 PMC4436567__F2 Effectors interfering with SA-dependent signaling and gene regulation 4881 219541 284930 PMC4437334__F1 Active killing of motoneurons through death receptors under pathological context 355 8772 1616 637 3459 3460 3458 4803 4055 PMC4438421__F3 TLR-ligand-mediated NFKB activation 7189 7187 29110 3661 114609 4615 PMC4439078__F5 Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes 3683 3672 1053 1050 9427 1647 467 57761 1390 947 10797 6664 122953 4327 10403 1649 2353 1052 4988 50943 79188 64651 4288 1051 51330 157313 7040 79056 8739 3669 350 83931 1894 7349 4212 3977 10112 PMC4439419__F1 Cell cycle arrest in senescent cells 324 1017 1021 1019 PMC4439562__F1 Cytokine and hormone signaling through JAK-STAT pathways 5618 2885 3717 25970 8660 2305 604 7166 5617 PMC4440546__F5 Context-dependent control of alternative splicing by RNA-binding proteins 3178 10922 1956 PMC4440769__F11 TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation 81858 7185 7186 23118 257397 10454 PMC4442271__F1 Obesity, immunomodulation and chronic kidney disease 3569 4049 4513 4512 717 5226 4050 PMC4449696__F2 Retinoid metabolism and the structure of retinoid receptors 5950 64220 3717 5914 1022 PMC4449815__F8 Inactivation of a GAs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis 10413 6469 6608 51684 4771 PMC4450280__F7 Estrogen regulates cell adhesion and polarization signaling pathway of osteoclasts 4637 6093 387 9475 388 3688 3695 3689 3696 3690 3691 5879 998 3693 5880 5881 3694 1398 9564 2889 5599 5906 3725 1399 5601 5908 PMC4458271__F2 Role of ceramides in neuronal apoptosis 7390 572 581 PMC4465592__F1 Attacking the Multi-tiered Proteolytic Pathology of COPD: New Insights from Basic and Translational Studies 4318 4317 3579 PMC4466682__F9 EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells 1950 1956 382 7474 PMC4467383__F4 Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery 54623 23476 8019 676 PMC4467525__F5 Summary of altered glucose metabolism in MCF10A-ras cells 2539 5230 3939 5163 PMC4467582__F7 Proposed schema of the pathways underlying renal protection conferred by xenon (Xe) preconditioning 27250 5728 7124 PMC4472235__F2 Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease 3643 5163 7248 7249 5091 2475 6009 1975 6010 3091 1977 6194 1999 PMC4478640__F8 Model for negative feedback loop by which the ARGOS family desensitizes ethylene signaling 7808 130497 116039 PMC4480161__F1 Cross-species comparison of PCD factors implicated in aging 51024 1759 199 2021 27429 PMC4487197__F2 Ephrin receptor signaling pathway (genes hypomethylated in the schizophrenia patient of Twin Pair 1) 5829 5998 6714 284 1950 2246 351 25791 8997 7247 6383 2885 998 387 6774 PMC4489427__F6 Integrated analysis of alterations in key pathways in nccRCC subtypes 3845 5728 8050 7248 7249 5161 6009 5162 3091 4286 7942 7030 201163 2271 6390 6392 6391 3418 7428 5546 PMC4490940__F10 Possible pathways of Cd-induced MAPK/ERK signaling 1839 914 1956 2885 6714 6722 2002 9846 PMC4495583__F2 Dendritic cell metabolism 29110 3099 7494 PMC4503872__F3 Results from a transcriptomic analysis of the OCM: Downregulated genes were, dependening on their level colored in green, upregulated in red 4522 10768 1786 4548 27430 1719 6470 7298 6472 4524 PMC4503882__F4 Postulated signaling pathway for MMF through binding to HCAR2 338442 10645 10135 23411 3553 PMC4504792__F6 Methylene blue-induced neuronal protective mechanism against hypoxiareoxygenation stress 4151 2056 2475 PMC4516163__F1 Numerous arrestin functions play a role in apoptosis and cell survival 572 4193 2353 581 PMC4516212__F5 Summary of the inhibitory effects of BSNXD on osteoclast differentiation.Notes: The suppression of BSNXD on RANKL-induced activation of the NFATc1 via ERA pathway is correlated with the inhibition of osteoclastogenesis 7189 6850 2885 4772 PMC4516462__F3 Transcriptional activation of DNA repair mediated by UPS-dependent pathways 4193 672 5371 4350 5111 1643 4436 7508 5395 5888 4255 4292 2176 PMC4519914__F6 Protein–protein interaction (PPI) network and ingenuity pathway analysis (IPA) 1964 1981 1965 1978 1977 8663 26986 6714 6667 1994 1654 672 8648 10499 8202 3661 10010 51260 29110 7514 2099 PMC4523609__F9 Upstream negative regulators of the Hippo pathway 1956 4018 6714 5163 9113 26524 PMC4526263__F1 Cellular alterations and molecular mechanisms involved in hepatic cystogenesis 59341 3479 1080 11231 3091 2475 993 PMC4528692__F4 ΔNp63 and TAp63 TF networks 4854 79192 2737 26115 4851 646 4087 6657 163732 83439 23314 2033 1051 29842 7020 6665 7157 1747 4609 50805 53335 10320 4066 60468 11178 3394 3899 861 3663 28999 7161 7409 333929 23764 4801 7942 80237 4088 51176 221895 11262 351 864 1870 4772 8115 1879 PMC4530307__F1 “aggressive pathway.” Up-regulated genes (red) and downregulated genes (blue) are interconnected in a pathway involved in cell cycle control 113130 9232 10926 1029 9212 7057 2965 10553 4609 7157 7251 891 3161 960 8525 9133 64105 1062 407054 406959 PMC4530997__F1 Selective delivery of ITCs to bladder on oral consumption and modulation of cellular targets by ITCs in BC cells and tissues 6420 995 100303716 1956 PMC4531834__F2 Extrinsic cell death pathway is typically triggered by members of the tumor necrosis factor (TNF) family of death receptor ligands, comprising TNF itself, Fas ligand, and TNF-related apoptosis-inducing ligand (TRAIL) 7124 355 8772 7186 1540 23118 257397 637 197259 8717 PMC4541496__F7 SKN-1 regulation in the GSC longevity pathway 145258 65095 407012 5465 7942 PMC4543455__F5 Canonical Wnt pathway 324 847 5105 7275 595 5467 PMC4552880__F2 Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis 25805 4086 729 4089 3458 9978 7057 6500 4087 4088 6667 387 10468 4838 PMC4553397__F1 Intracellular mechanisms involved in the control of FGF21 production and action on the heart 7352 23411 26291 6648 5465 2260 PMC4558313__F4 Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes 5091 22926 200186 90550 10533 59341 759 PMC4574066__F2 Downstream analysis of Wnt-related gene expression from aged animals predicts a decrease in cell viability and transcription of RNA 1325 5970 8061 2114 3586 595 3565 4609 6423 7088 6662 6469 1956 3606 6347 7099 387923 652 3552 3976 3654 PMC4581295__F2 Signal pathways of chondrocyte hypertrophy 2487 650 652 324 4090 4086 2932 1499 6662 2247 860 3549 PMC4584279__F3 Selected signal networks induced by Dectin-1 and Dectin-2 6850 5091 5894 5336 64170 8915 2885 759 5971 1959 4513 1960 6364 PMC4586293__F2 Neurohormetic Phytochemicals: An Evolutionary - Bioenergetic Perspective 3479 2475 7249 7248 6009 2309 23411 PMC4586477__F2 TAA-specific CD8+ T cells often lack co-stimulation for an immune response against tumors 940 942 941 920 6850 27040 2885 2534 1445 7535 7409 998 3702 5058 2353 PMC4590620__F4 Alcohol’s effects on fibrogenic pathways in hepatic stellate cells (HSCs) 3929 929 7099 25805 PMC4590954__F5 Non-Smad signaling in response to TGFB1 and BMP-7 655 2885 7189 2475 1499 999 1000 PMC4593030__F7 Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway 80854 10891 4780 847 6648 7295 PMC4595834__F7 Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4Beta-S-aromatic heterocyclic podophyllum derivatives display antitumor activity 8772 472 545 PMC4596691__F4 Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNG Regulation 7124 7040 7423 7422 1438 2919 2920 92 6364 2921 3977 10803 3624 3579 3625 5473 3791 3626 6367 2324 6363 3082 1236 1950 4254 2322 1956 3560 1436 4804 2833 1270 3815 659 657 1271 23529 7852 650 4055 4050 3439 3456 1489 655 3561 356 355 1441 939 3952 3953 8744 1232 85480 50604 64806 2829 11009 2826 2057 2056 1896 10913 2688 2690 2689 84273 5617 5618 51561 84957 7066 4352 55801 PMC4598091__F1 Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype 84525 5728 6850 8900 1611 PMC4598780__F1 DNA damage response activates cell cycle checkpoint 9656 3014 11073 472 545 84126 1647 993 994 995 7465 PMC4603304__F5 Signaling pathway analysis of the potential mature EBOV miRNA target genes 6404 1409 6908 8737 4794 718 PMC4605443__F1 The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective 54209 7006 100124696 6714 2885 6850 6654 64170 2932 1499 PMC4618674__F2 Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans 5447 7014 2077 1356 6010 998 2934 1072 PMC4622586__F1 The classical complement pathway initiated by mAbs and its inhibitors 718 2271 4179 720 7448 966 730 729 727 1604 PMC4629442__F1 EGFR and its signal pathway 1956 1950 7039 2885 6774 6714 2549 5728 2475 572 596 PMC4637163__F3 Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer 942 7097 9332 6774 999 3553 4282 PMC4646664__F1 Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics 56913 2973 5728 7249 7248 1977 6194 PMC4647833__F3 Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing 808 5350 27063 125972 845 84665 6717 154 91624 57158 8736 70 7273 88 6262 4607 7139 7414 7134 10763 1355 2717 55750 85366 10627 51778 4633 4703 51422 2395 5894 291 4634 7071 7172 1674 11222 3920 4088 355 7170 8048 221937 PMC4654537__F6 Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule 210 367 23149 55163 8192 5064 2592 5467 130589 134147 286205 1140 PMC4658161__F7 Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NFKB Signaling 81858 55072 2138 2139 5728 PMC4667791__F5 MAPK pathway has been invoked in phospholipase A2 activity that could release arachidonic acid, perhaps in concert with VEGF, and thereby amplify 20-HETE formation () 1579 8529 260293 199974 4015 PMC4676991__F2 Autophagic signaling pathways associated with oxidative stress 472 5728 5163 7249 7248 9776 8408 7405 2309 664 PMC4677817__F2 Contribution of Metabolic Reprogramming to Macrophage Plasticity and Function 7216 435 383 PMC4680864__F3 Proteome Analysis of Ground State Pluripotency 3099 2810 5226 5214 6647 3945 2475 4967 PMC4684888__F1 Interactions of oxidative stress, inflammation, insulin resistance, and hyperandrogenemia are described briefly in the figure, which are all involved in polycystic ovary syndrome physiopathology 3603 3643 6462 3484 3479 PMC4686085__F4 Axon guidance pathway involving neuropilin 1 7054 4750 1630 387 998 2534 7852 6092 6091 64221 2242 10371 29984 5810 8482 PMC4687703__F2 Local inhibition of miR‐24 in ECs would turn off apoptosis signalling pathway and improves reparative angiogenesis in post‐ischaemic conditions 23411 59277 10298 11082 5921 355 PMC4694853__F8 Non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation 84890 2475 6194 PMC4695002__F2 STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation 3918 2475 6774 10445 7917 1829 57521 79050 3664 81493 6714 8842 79784 PMC4695002__F6 STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation 4609 27303 4781 6774 9611 26137 1960 23194 25788 406991 1961 1894 1958 7020 4436 6599 6667 10499 81671 1385 PMC4699388__F7 Overexpression of E2F-2 abolishes the PPP-mediated inhibition of terminal differentiation in Gata1S310A erythroid cells ex vivo 2056 3621 3480 3479 51327 212 PMC4702137__F8 Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu 1499 8650 595 PMC4702912__F6 ‘Wnt Signaling pathway’ from KEGG () (ID hsa04310) 51701 9350 1499 4089 4088 4040 4041 324 25805 50964 6500 6477 8454 9978 387 23002 9475 6965 PMC4703831__F3 Genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia 2006 2923 4904 10482 81567 2023 6612 369 2246 4915 3627 1654 10155 4924 7431 7078 310 7043 290 4953 6774 5054 1515 7490 7057 1282 3069 3105 1192 3308 3958 4076 10232 7430 3326 8720 4170 3479 81 3191 9445 1958 4313 7341 2274 PMC4706383__F8 The proinflammatory role of HECTD2 in innate immunity and experimental lung injury 7124 7099 2932 8554 PMC4708176__F2 ERK and non-ERK mediated non-genomic AR signaling 6462 367 6714 5894 2475 2002 7018 2308 PMC4710174__F1 HSC aging and senescent immune remodeling 7474 6387 998 1499 6304 PMC4710869__F1 Simplified schematic summarizing the BMP signalling pathway and genes that have to date been shown to be mutated in PAH and demonstrating that many of these mutations encode protein involved in BMP signalling 3777 27302 857 PMC4712330__F4 PTEN tumor suppressor gene and its role in lymphoma pathogenesis 6850 5728 5163 84433 8915 2475 930 PMC4712465__F1 Scheme showing role of pro and anti-inflammatory bioactive lipids in IBD 4282 3146 3565 PMC4721605__F2 Key signaling pathways that regulate activity-dependent translation initiation in neurons 3479 5728 1363 5073 1977 5163 7248 7249 51247 83939 6009 1975 468 PMC4726830__F3 Emerging targets for glioblastoma stem cell therapy 2885 5728 6714 2475 64223 253260 9833 PMC4730267__F2 Gene members (green rectangle) in the PPAR signaling pathway that are regulated by maternal high fructose in the male offspring kidney at one day of age (red stars) 5360 10297 4023 4312 7350 3611 PMC4743530__F3 Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis 1499 55897 324 PMC4745004__F8 Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile 25805 4089 3458 9978 8454 6500 7057 1874 5266 6093 387 10468 4838 PMC4756317__F6 GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway 6746 7490 51083 PMC4757520__F2 Signaling pathway alterations in Kupffer cells after alcohol and/or burn injury 3929 929 7099 51135 7124 PMC4759558__F12 CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone 1240 6770 652 PMC4765525__F1 Wnt signaling pathway from KEGG 759 5447 2932 4089 324 11197 25805 50964 6500 8454 9978 8027 9475 PMC4765532__F3 Wnt signaling pathway including microRNA regulation 1281 1277 6423 50964 4038 4040 4041 79412 324 1499 PMC4767455__F1 Role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications 8450 8451 1642 759 7508 1643 7249 PMC4768069__F2 Bioinformatics analyses reveal changes in expression of genes associated with the Death Receptor Pathway 355 8717 10010 8772 1616 7186 637 56616 27429 PMC4770149__F1 Developmental pathways are frequently activated in cancer 6608 324 3516 PMC4772904__F1 NSAIDs inhibit PGE2-induced tumorigenesis through targeting multiple downstream signaling pathways of PGE2 4512 1499 2932 1956 PMC4773560__F1 Mathematical model of adrenal steroidogenesis in NCI-H295R cells 1583 3284 3293 1589 1584 1325 PMC4773818__F6 Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention 7046 7048 4087 4088 387 PMC4783088__F2 Regulation of hepcidin antimicrobial peptide (HAMP) expression 9518 2056 3077 7036 57817 10682 PMC4783948__F5 Highest-scoring and fifth highest-scoring pathway maps for the last two time points post-TBI (24 and 72 h) 4088 6502 6500 997 9978 5347 1019 983 1017 1869 545 472 6010 3265 998 9475 847 5898 5863 3985 5058 595 5170 2932 10140 1021 4193 1386 890 5970 6774 PMC4784386__F4 Functional interaction network of the final set of 50 genes prioritized with the consensus strategy and 100 additional interacting genes 5955 8036 4695 55967 8050 6091 4719 1629 1738 1743 4967 6729 6728 2806 1431 1737 6636 6120 6727 6631 6637 6730 4172 4999 2965 2960 990 6626 23020 27243 4998 2071 4173 2961 1153 92421 128866 6427 10594 5000 4174 8175 4331 10926 4176 222229 6627 2068 4686 6628 51652 22916 23595 5119 4116 5465 178 7220 7054 2146 2534 6622 5836 5834 1457 8788 1813 8535 183 5468 788 2632 23492 351 1912 5999 6045 1375 3172 2101 4899 6418 PMC4784386__F5 Functional interaction network comprising gene sets prioritized by Limma and ML 7162 1410 6324 5527 9874 5310 9469 5795 6337 7857 5549 545 10606 1114 3098 7539 5019 11081 6847 2643 5979 1111 51751 659 81563 1612 79912 10231 5864 6857 2800 51302 3084 5885 5166 2101 3763 10380 10947 10598 7092 2218 55717 51188 9140 10944 30827 784 2632 9946 27244 577 10493 9517 11171 6571 6731 4036 4191 5955 5134 25797 8623 574 4880 563 5033 6625 185 10521 53 5495 7411 2019 9604 5197 29766 28513 5799 3642 2173 3708 23432 5695 9143 55885 4495 11024 6399 3547 6017 648 1738 10397 1813 5100 26959 51582 5068 5351 59347 23457 51232 9369 7054 8036 1195 8788 51696 10286 10989 6612 10960 23531 55521 9525 55800 51760 10381 892 9376 5669 8624 902 1153 5999 5087 5935 400 8027 1617 2592 10516 324 8723 6596 8677 5649 9223 51231 353511 5409 56128 10747 10106 5027 3759 5218 5936 5428 6235 5146 1875 6709 3679 6404 4801 9500 7769 10129 6597 11034 5294 81034 2157 5933 23676 64395 23543 8815 3643 8533 2660 71 6129 864 23409 23530 10333 51138 58155 489 6772 10100 3600 4303 2792 8504 4920 PMC4786287__F1 Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic Profiling 109703458 54995 197322 PMC4790094__F2 Divalent cation signaling in immune cells 613 84061 54822 3932 6774 PMC4790585__F1 Wnt/Beta-catenin canonical pathway 2932 324 1857 1856 1855 1499 5879 23002 23500 387 51199 9475 51701 51176 607 PMC4790585__F2 Wnt cross talk 1950 1956 2549 9846 2735 2736 2932 572 4193 1499 5728 2475 999 581 PMC4791205__F11 YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells 9113 26524 2260 2263 2261 2264 PMC4795487__F5 KEGG pathway analysis., The integrated pathway showing the interactions of differentially expressed proteins in apoptotic and survival pathways 8772 836 8717 840 7186 637 842 100653365 3562 472 572 100506742 PMC4797178__F5 GeneGO pathway map “Development_TGF-beta-dependent induction of EMT via SMADs” is significantly enriched for genes differentially expressed between MCF-7-Snail and MCF-7-Control cells 3082 4088 4087 4089 3611 6667 8091 23462 2113 3398 387 1000 PMC4800296__F1 Simplified representation of the PI3K-AKT-mTOR pathway in pancreatic neuroendocrine tumours 3667 5728 6009 2475 253260 7249 7248 2887 PMC4802403__F1 The mTOR pathway, it's classical upstream inputs and downstream targets.mTOR exists as two separate signalling complexes which are structurally distinct 1956 3667 2885 64798 253260 2475 7248 7249 51256 2887 PMC4802898__F5 Mechanism of DQP efficacy on CHD rats 4023 7038 948 4513 PMC4809260__F2 Oxidative stress under ambient and physiological oxygen tension in tissue culture 9817 7099 5970 1386 581 637 PMC4811695__F3 Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects 26291 9675 729 2475 64798 207 2303 253260 7350 PMC4813194__F2 The intrinsic apoptotic pathway is triggered by various stimuli inducing mitochondrial membrane permeabilization 7124 581 8717 8772 PMC4817553__F1 The Hedgehog signalling pathway in Drosophila and vertebrates 6608 51684 374654 PMC4818358__F1 Roles of interleukin-10 (IL-10) in determination of pregnancy 5212 6774 3716 PMC4818947__F7 Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents 4255 545 472 PMC4822123__F8 Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice 5879 6774 135935 2661 9210 182 4853 2475 PMC4823347__F5 Molecular signaling partners of ROCK1 387 6093 3984 PMC4825019__F5 Ingenuity pathway analysis identifies two highly enriched networks for the Tau-interacting proteins 79012 759 4137 10540 1431 PMC4826689__F2 Noncanonical Wnt signaling pathway (Beta-catenin-independent Wnt signaling pathway) 324 51701 1499 PMC4827621__F9 Deletion of KvB1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts 3751 30819 3553 7881 4624 2626 PMC4829553__F3 Sex Difference of Egfr Expression and Molecular Pathway in the Liver: Impact on Drug Design and Cancer Treatments? 27023 51303 8214 1361 3190 1874 10160 3550 732 2780 3418 1962 284161 8517 163 204 1956 10998 4282 23471 10959 9791 10952 7001 84255 10342 23480 89886 6476 6745 5902 PMC4831128__F6 Ingenuity Pathway Analysis (IPA) of cholesterol and bile acid metabolism genes 9619 5468 4864 19 348 5465 6256 10062 PMC4831838__F4 Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media 566 4069 671 4057 5657 1991 6280 1511 1992 4353 1755 51297 5284 4583 3684 PMC4837341__F4 Drug target identification using network analysis in Sini decoction 2731 2645 254531 9415 55586 1610 10400 5236 10423 790 23761 8399 443 440 50487 226 189 PMC4841026__F5 Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study 1643 10488 8740 2879 7980 3725 1910 8754 8570 2908 116 56924 55065 3075 64319 1499 8260 PMC4848607__F2 Summary of the Toll like receptors (TLR) and RIG-I like receptor (RLR) pathway genes based on upregulated genes shown in and excluding the downregulated genes shown in and 89870 3661 3665 PMC4849781__F2 HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data 10750 101448070 5064 847 1215 4351 PMC4850468__F1 Molecular Mechanisms of EndoMT 857 4088 4089 4087 50507 6469 3091 5727 6608 4851 1311 7076 PMC4860161__F1 Autophagy pathway 2475 9474 9140 8408 PMC4863644__F2 Glucose stimulated insulin secretion (GSIS) and suggested stimulus/secretion coupling factors 5091 23152 2695 PMC4863733__F2 Birth of a Carcinoma-associated fibroblasts 6469 2920 5156 6678 10630 1301 948 5159 2191 2294 PMC4865030__F2 Interplay between Fanconi anemia and homologous recombination pathways in genome integrity 91442 11073 545 472 5888 672 29089 3398 675 8105 4172 4174 4173 4176 4175 4171 PMC4865369__F7 Model for wntP-2, ptk7 and ndl-3 in control of patterning 5754 8321 8324 2535 4537 4535 4536 PMC4868686__F6 VE-cadherin cleavage by ovarian cancer microparticles induces Beta-catenin phosphorylation in endothelial cells 4318 4313 1499 5879 324 5058 1003 4312 595 51176 4316 4041 PMC4871335__F2 High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis 27430 4357 875 27232 2731 2805 635 10993 29958 2875 84706 27165 125061 6999 1373 445 5053 3081 5625 4329 PMC4872542__F9 Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro 2932 841 842 836 355 PMC4872805__F3 Sirtuins as regulators of metabolism and healthspan 23411 3172 2308 200186 22933 51548 3091 7351 3418 6648 23410 23409 PMC4877005__F2 Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure 287 6711 23136 4684 161 6712 6709 7415 4744 1267 87 88 5339 4905 81 816 6624 PMC4877005__F3 Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure 6855 493 8867 27445 9900 492 488 1759 8927 2902 490 6709 1808 287 PMC4879098__F1 Lysosomal–autophagy pathway 581 637 790 4074 3916 PMC4880841__F1 Summary of NDR/LATS kinase signalling functioning downstream of Ste20-like kinases and upstream of the Hippo effectors YAP/TAZ 4485 9113 26524 22848 PMC4881178__F7 Proposed pathway of ASPE signaling in MDA-MB-231 cells 1021 1019 581 1017 PMC4884395__F1 Kynurenine pathway of tryptophan metabolism 3569 3553 169355 8942 2670 PMC4885545__F2 Luteolin (Lut) modulates cancer cell cycle progression 2322 3479 3480 3667 367 2932 2475 5660 PMC4887335__F1 Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes 1540 8717 257397 23118 197259 637 8772 PMC4891982__F4 Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage 4118 5091 11113 10873 4200 PMC4894314__F4 TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock 4615 3661 7099 PMC4894418__F5 Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing 1610 627 4351 5894 2316 2196 7186 355 1616 4149 929 100187907 51701 PMC4904844__F5 Interaction network of 135 SNO-modified proteins identified in WT and AD mouse brain tissues 1211 5881 387 4694 2580 4190 4720 4695 4191 1431 3420 2023 3418 PMC4905058__F2 General overview of the class I PI3K signaling pathway 717 7249 6009 695 572 2549 9846 387 PMC4905175__F1 Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis 55183 25913 472 PMC4911278__F5 Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression 2539 3101 25796 229 5728 5106 5313 7249 7248 1738 6009 5166 PMC4917857__F3 Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis 3156 2222 6713 4047 1718 7108 50814 51478 10682 6309 1583 1717 PMC4926172__F2 Downstream targets of mTORC1 983 2475 6009 1999 PMC4927085__F8 Long noncoding RNA LINP1 regulates double strand DNA break repair in triple negative breast cancer 472 108570035 3981 1956 PMC4933505__F1 Emerging role of coagulation proteases in kidney disease 7018 7035 324 2147 5091 PMC4934886__F4 Aortic valve stenosis–related biological processes 6352 1236 3586 7124 5468 341 3383 80830 3156 7040 7048 6368 4311 4018 5360 3949 23705 5155 7412 2262 186 6387 57863 57512 183 3329 1230 3339 3718 348 338 7422 185 4035 253559 5097 4843 3560 3559 1636 53353 4846 624 633 6401 1634 3373 6362 6363 316 6775 51148 3897 283120 623 1462 90378 176 2919 9547 2833 2354 58191 6609 4257 7130 64344 2353 6648 51330 1281 5265 6868 7079 145258 2253 1522 9068 1839 23452 634 8530 1306 57124 5348 2006 7077 1301 1300 51196 3116 3111 4316 4318 3791 7076 2022 1513 1508 3200 8842 93035 1511 1520 5175 7078 4312 5328 1471 1509 5352 26499 57480 8038 4313 1303 4017 283392 29953 81030 23493 5045 26585 4060 860 650 27123 4851 4091 652 4256 3381 6696 861 5914 864 4982 1499 1116 6662 4488 632 8660 5916 249 8792 3783 7473 6422 4920 8600 115908 84337 27122 197 441478 11197 3371 3695 PMC4939324__F3 Anti-inflammatory mechanisms of MFG-E8 in a LPS-TLR4 signaling pathway 7099 929 6774 9021 PMC4939482__F1 Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure 59272 1636 367 PMC4945937__F8 Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway 4193 2744 57103 581 5315 3939 PMC4946894__F1 Apoptosis pathways in various organisms 6497 7124 581 PMC4947555__F3 Histological chorioamnionitis shapes the neonatal transcriptomic immune response 6688 11040 2309 1053 302 PMC4951264__F8 Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways 208 4170 595 PMC4955846__F1 Toll-like Receptors, Triggering Receptor Expressed on Myeloid Cells Family Members and Receptor for Advanced Glycation End-products in Allergic Airway Inflammation 6850 3654 51135 2885 7189 3717 6774 5163 PMC4959097__F1 Cholesterol biosynthetic pathway 3156 4598 10654 4597 3422 91734 4047 PMC4959441__F1 RAS-mediated signal transduction pathways and post-translational modification of RAS 1956 1690 5900 5898 5899 9986 2475 PMC4962009__F1 Replicative aging cooperates with other aging mechanisms to activate the p53 and/or Rb signaling pathways 545 472 1021 1019 983 1017 PMC4963239__F4 Mediator complex: a central integrator of transcription 4615 7187 3665 51586 9439 9440 9968 1499 PMC4963810__F1a Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer 2932 1499 324 4040 4041 PMC4965186__F5 a) Systems modeling framework used in this study 1312 2862 2539 6120 PMC4971383__F1 Feedback loops that form the molecular clock 23411 10135 9575 1407 1408 8863 8864 PMC4973221__F3 Transcriptome landscape of Synechococcus elongatus PCC 7942 for nitrogen starvation responses using RNA-seq 5236 55276 7909 6389 5447 5091 22934 5223 PMC4975146__F2 Signal transducer and activator of transcription tyrosine kinase domain c-Kit in normal cell.Notes: Ras/Erk pathway directs to activate of the proliferation genes 2885 5163 2475 PMC4975451__F8 PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide 5728 5163 572 PMC4980583__F5 Thumbnail image of MAPK signalling pathway 4351 6722 2316 7124 1616 4149 51701 768214 23118 7189 100313892 PMC4984446__F1 The importance of ribosome production, and the 5S RNP–MDM2 pathway, in health and disease 6135 6125 4193 55003 PMC4985526__F1 Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy 1956 3845 7048 7046 5266 5728 4089 2475 4092 PMC4987476__F8 Graphical summary of anti-inflammatory activity of bee venom in LPS-activated BV2 glial cells 7099 3654 7189 4615 PMC4991739__F5 Dynamically alternative pathway network 283601 3371 858 761 100507274 8544 613 PMC4992436__F3 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology 91662 1540 8915 5971 7189 7186 7187 PMC4996775__F9 Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson’s disease 7018 6120 3240 PMC5000717__F2 The Hippo/YAP pathway is physiologically initiated via GPCRs 4485 9113 26524 PMC5003635__F3 Oridonin regulates multi-signaling pathways to display corresponding multifunctional effects 581 9817 317 PMC5007826__F6 Working model of PRL-3 involvement in TNF-R1 pleiotropy 8717 7186 8772 PMC5008272__F7 Monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model 22943 4041 324 2932 PMC5008362__F1 Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach 427 56848 8877 27163 130367 81537 253782 29956 204219 10715 79603 91012 64781 7368 8879 7357 166929 259230 6609 6610 55512 55627 PMC5010532__F1 Adaptive UPR in Parkinson׳s disease 627 7494 22926 468 83939 PMC5010983__F1 The (A) Wnt/Beta-catenin, (B) AKT/mTOR, (C) ERK/MAPK signaling networks that are important for oligodendrocyte development and myelination 324 3667 2932 5728 1499 7249 5163 2475 253260 4040 4041 PMC5011664__F2 Non-canonical wingless/int-1 signaling pathway 2534 4920 6259 6714 387 7249 2475 1386 140805 PMC5016220__F1 Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets 94103 64781 6611 124976 6693 55937 1901 9294 1903 8698 53637 PMC5016220__F2 Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets 1901 9294 1903 8698 6010 PMC5025072__F5 Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer 7066 3600 3952 5777 3566 867 23624 868 30837 3716 9063 3458 5781 8027 10254 1154 5290 2033 1387 6772 2885 5292 207 208 10000 10379 4609 6655 50964 161742 200734 399473 81848 10252 10253 PMC5026315__F1 Glomerular basement membrane heparan sulfate in health and disease: a regulator of local complement activation 715 716 10747 5648 718 717 727 729 735 730 PMC5027283__F5 Oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway 3417 3418 9682 64798 PMC5027289__F7 PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development 54361 4158 1585 1584 7536 6469 2735 PMC5029667__F7 PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells 5292 4194 4193 PMC5034935__F3 Proposed mechanisms by which the interaction of dietary long-chain n-3 polyunsaturated fatty acids from fish oil and butyrate from bacterial fermentation of dietary fiber may reduce colon tumorigenesis 759 836 839 840 29940 PMC5035631__F1 Sweet path to metabolic demise: fructose and lipid synthesis 3795 2645 2998 229 5313 31 2194 4547 PMC5037594__F7 Signaling pathways in EGF-induced AREG mRNA expression 1950 1956 374 PMC5037849__F2 Dock3 signalling pathways in optic nerve regeneration 391 5879 1795 2932 324 PMC5040753__F7 Proposed mechanism of mechanical stretch-induced VSMC hypertrophy demonstrates that the RhoA/ROCK pathway activation, calcineurin activation, NFAT nuclear translocation, and leptin synthesis are involved in this process 387 6010 718 PMC5042386__F1 Schematic overview of the Hippo signaling pathway 60485 4485 55233 9113 7003 8463 7004 7005 PMC5050041__F1 Neuregulin 1 - erbB4 pathway in schizophrenia: From genes to an interactome 3084 2885 27185 84062 5662 5999 10142 2534 6714 PMC5053399__F1 Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening 3535 2885 2549 PMC5055212__F6 Gene network construction 4313 4312 5898 10000 3913 51176 8323 6502 4149 PMC5058780__F2 FAK and paxillin, two potential targets in pancreatic cancer 6714 6010 2885 PMC5059721__F6 Carbon Ion-Irradiated Hepatoma Cells Exhibit Coupling Interplay between Apoptotic Signaling and Morphological and Mechanical Remodeling 717 637 581 56616 PMC5062963__F7 Comparative model of transcriptional activation of ERA by cognate ligand versus cAMP signaling in the absence of estrogen 10498 5978 23426 10013 3065 PMC5064357__F6 Novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes 3667 8394 1608 PMC5071175__F4 Planar cell polarity (PCP) proteins and spermatogenesis 4920 23002 2011 998 5879 387 PMC5084027__F4 AMP-activated protein kinase (AMPK) signaling pathway 3630 6714 57521 6904 2475 2194 3156 1080 9370 23417 1938 155 4846 8660 1376 3991 5577 6517 148 208 3643 29904 2997 5209 PMC5090056__F1 Models of Hippo pathway in fly and mammals 92359 154796 10207 4771 4485 60485 92597 55233 9113 26524 PMC5094991__F7 SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline 7220 1956 84876 1950 6786 PMC5095106__F3 TNFR1-elicited signaling pathways 7124 27035 55312 7186 8717 1540 27005 8772 PMC5097173__F10 Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA 56852 353497 8554 5111 PMC5097364__F4 T3-actions from genomic and non-genomic effects on cell adhesion and differentiation during vertebrate development 324 6957 6955 5879 6772 999 1499 PMC5097897__F4 Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling 960 961 1956 PMC5098276__F4 CCI-779 treatment induces expression change in mTOR signaling pathway components 2475 3091 253260 6009 7249 1977 673 PMC5104457__F1 ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis 1362 8737 11035 197259 PMC5110612__F1 Proteins with known or inferred roles in autophagy that underlie muscle pathologies in mice and humans 9531 26353 4534 64419 4077 10533 9474 9140 203547 596 7415 3920 4000 PMC5112586__F1 Histiocytic Neoplasms in the Era of Personalized Genomic Medicine 238 4914 6654 2885 3667 369 673 4214 PMC5114345__F4 Mechanotransduction through integrins and primary cilia 59341 6714 6778 1499 PMC5114520__F1 Double-strand break can be repaired by cNHEJ with minimal end processing 4361 10111 3981 7518 10721 142 3978 3980 5888 672 675 PMC5115347__F1 The degranulatory signaling cascade of RBL‐2H3 (adapted from refs 27040 4067 6850 PMC5118702__F5 Molecular and biological pathway interaction map analysis of altered proteins from the CCI samples (1 vs 2023 6812 23114 811 PMC5122439__F2 RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action 1956 3480 2885 161742 2549 5921 6654 3845 3265 369 673 PMC5125896__F1 Biosynthesis, remodeling and turnover of mitochondrial cardiolipin 10555 55326 4018 283871 9489 PMC5130051__F2 Engineered nanoparticles induce cell apoptosis: potential for cancer therapy 355 847 8772 637 581 23411 PMC5131002__F2 YAP mediated gene expression in liver fibrosis 6010 4485 999 154796 9113 81532 27063 PMC5131753__F2 Possible mechanisms of ribosomal proteins L5 and L11 signaling to MDM2 6125 6135 4193 PMC5131952__F7 Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor 84876 5174 6786 PMC5134126__F1 Osteoclasts arise from hematopoietic monocyte/macrophage precursors upon interaction of RANKL with its receptor RANK 7189 4087 4088 4089 4772 2353 PMC5136518__F1 Alterations in DLPFC layer 3 pyramidal cells in schizophrenia 998 396 5058 5063 5062 3984 3985 PMC5139348__F1 PI3K Pathway in B Cell Metabolism 613 3566 958 5728 47 5163 2308 7249 7248 3099 PMC5140697__F2 Targeting cancer metabolism: dietary and pharmacological interventions 3479 3480 1956 2475 PMC5141617__F4 Conflict resolution in the genome: how transcription and replication make it work 545 84232 54617 4360 4553 23064 672 PMC5143371__F2 Cellular metabolic pathway involved in redox homeostasis 5226 4199 3417 2937 10797 4522 PMC5145800__F1 Astrocytes and neuronal activity play distinct, cooperative roles in neuronal redox homeostasis 9817 8452 2936 2730 7295 847 4094 2729 2645 PMC5173156__F6 Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factorB1 7421 999 1000 9314 PMC5177517__F6 Proposed model for the mechanism of SNRK regulation of ROCK activity 6010 54861 5163 5728 PMC5179551__F1 Insulin signaling pathway: intracellular insulin signaling is initiated by insulin receptor tyrosine kinase activity leading to the activation of both the PI3K-Akt pathway and the MAPK pathway 2885 2932 572 PMC5181590__F3 Specific intracellular signalling pathways are predicted to be abnormally activated in resting HD monocytes 929 7099 6774 4609 PMC5187800__F8 Schematic representation of metformin roles in TGFB1-induced epithelial-to-mesenchymal transition in cervical carcinoma cells 999 2475 6774 PMC5187940__F3 Effect of Pb on the signaling pathway TLR4-MyD88-NFKB and the production of pro-inflammatory cytokines in microglial cells 4615 51135 7189 3725 1386 PMC5215656__F6 Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways 4803 790 5058 1499 1020 2354 1958 PMC5215890__F6 The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans 3364 23626 389058 6671 6670 80320 100131390 121340 6668 6667 221833 PMC5217378__F6 Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.25 Gy of 48Ti ions 3898 145957 5143 1849 8600 255324 9119 56940 1850 55578 3885 9374 2885 5925 115362 8833 3630 1977 8540 10791 8637 9283 PMC5217378__F7 Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.5 Gy of 48Ti ions 4830 5481 5887 898 7001 210 27044 6169 6128 11224 10528 PMC5225790__F11 Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies 6654 4893 3845 3265 158401 8036 5480 161742 4193 673 5163 5728 PMC5226503__F4 Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma 3099 6120 84076 5095 6472 2026 5230 80201 6470 25796 229 4524 PMC5228544__F1 Roles of TBX2 and TBX3 in tumorigenesis and tumor progression 10397 4193 5371 1958 1499 8000 9271 6909 6926 5728 10000 999 1000 PMC5239457__F7 EIF2A serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress 83939 468 4485 11059 9113 26524 2308 PMC5249001__F3 Pathway Studio guided network that describes regulatory connections between the deregulation of Aurora kinases, caspase-3 and osteopontin-encoding SPP1 9212 153572 5457 836 7422 6790 6696 3630 PMC5256158__F5 Schematics of multitargeted actions of T1AM on metabolic and steroidogenic pathways 5468 7038 4118 11113 57678 355 6720 6721 123 6770 PMC5260963__F4 Protein interaction map 7035 9223 721 2159 1462 55740 28776 28908 7444 64167 2346 596 9826 2589 2064 4153 79868 164656 3958 920 4606 9172 25802 4173 653361 93408 1719 9636 11075 4151 PMC5264327__F8 Working model representing the proposed signaling pathways induced by vitamin D signaling in regulating skeletal muscle mass 7421 3569 3570 6194 4088 6774 2309 664 10682 PMC5267336__F1 Clinical applications of mouse models for breast cancer engaging HER2/neu 1950 5728 5163 2475 2002 2113 4609 595 PMC5267440__F1 Molecular regulation of macroautophagy and targets for pharmacological stimulation of the autophagy-lysosomal pathway 7249 596 7942 8408 9776 PMC5279772__F6 Inhibition of NFKB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy 8772 5970 3550 PMC5286530__F1 FGFR signaling pathway 2246 2255 26291 2248 27006 2252 7083 7084 2885 2549 6772 6774 26136 PMC5289288__F1 Identification of KRT16 as a Target of an Autoantibody Response in Complex Regional Pain Syndrome 3492 2158 4800 7177 2768 5265 302 208 5268 953 60 1992 10488 183 1915 1515 2670 3329 5315 3858 226 3866 3861 3872 203068 4397 PMC5289991__F1 MYC regulatory networks in pluripotent stem cells 3939 3976 4609 6774 1849 1844 6422 22943 54496 121536 3065 PMC5292133__F3 Network of the genes related with post-translational modification, cancer, and tumor morphology 3619 29128 5727 11035 771 586 1022 27254 27316 132 4609 3920 6253 2004 8237 7172 100506742 PMC5292133__F4 Network of the genes related with cancer and DNA replication, recombination, and repair 10733 3603 3693 5933 5426 4128 5480 367 3475 6714 5469 382 22822 7037 PMC5300050__F3 Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly 6850 948 6194 PMC5302036__F3 Switching off malignant mesothelioma: exploiting the hypoxic microenvironment 5893 4292 4436 7317 7318 2475 558 1956 8314 894 891 1029 3939 5163 3099 3098 PMC5306179__F1 Canonical and alternative pathways for NFKB activation 7124 1611 613 5966 5971 PMC5308218__F4 Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization 221184 3939 832 4904 79705 830 5782 829 2885 9846 7277 23616 4690 8440 5781 5921 613 5291 5295 9046 867 1398 1445 10677 2889 87 226 5052 26999 4739 3329 26227 10254 399687 55970 7006 100124696 10163 10399 25 9146 50618 51517 5501 23607 58513 5296 6464 1399 1796 3071 7531 7529 10006 7534 PMC5310224__F5 Unfolded protein response in immunity and inflammation 22926 22809 468 7494 10628 7124 114548 3553 PMC5313453__F2 Figure illustrating five pathways putatively causing pathological remodelling in ACM: 1) Deficits in EB-1 ID protein trafficking provoke disturbance of the ID morphology 5350 2932 1499 PMC5314324__F5 Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity 1431 5757 27338 207 PMC5319910__F4 Histone chaperone networks shaping chromatin function 4678 9874 11011 55705 79711 8520 4171 4796 1616 7290 546 PMC5322464__F3 MapMan overview of significant (FDR adjusted p ≤ 0.05 & log2 fold change ≥2) differentially expressed loci (SDEL) involved in biotic stress pathway, unique to PB1+Pi9, upon M 9242 2077 4602 PMC5326762__F2 Pathways of HIF-1A and its target genes involved in retinal neuroprotection 7428 3667 55872 208 9817 2056 133 PMC5332939__F1 Diagrammatic representation of the EGF signaling pathway 1956 2885 6770 PMC5334292__F1 The possible role of the polyol pathway in diabetes atherosclerosis 4693 7018 10135 PMC5336482__F2 Involvement of GSK3 in TLR4 signaling pathways.Activation of TLR4 by LPS or alarmins (called ligand in the figure) involves dimers of TLR4 binding to CD14 and MD-2 929 4615 7189 7187 29110 3661 7099 PMC5341794__F1 PD-1 signaling 324 940 7535 3558 PMC5342987__F1 BMP4 cellular signaling pathway including activators and inhibitors 57154 64750 25805 PMC5345622__F1 Occurrence and regulatory mechanisms of ferroptosis in a cell 3658 1431 80221 7417 2879 3652 7018 PMC5347713__F7 Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway 114609 4615 7189 595 7099 PMC5348387__F6 Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis 581 637 572 56616 PMC5352068__F14 PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide 7249 6774 6648 2475 8408 637 472 9776 83939 PMC5352205__F8 Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness 673 4318 999 PMC5354742__F3 Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells 3479 5196 170589 60675 4313 4922 4878 7474 4485 155 59341 19 6517 2260 776 9452 4345 4907 5144 1356 5444 284485 6999 27115 246 5166 4773 6886 8864 2627 PMC5354945__F2 Therapeutic small-molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways 958 7186 7187 8772 8717 197259 836 5971 5970 PMC5355171__F2 Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? 5728 3845 998 5163 572 2932 581 PMC5356307__F7 Model describing the effect of a synergy between extracellular TGFB1 and Hsp90B on downstream signalling in colon cancer cells 7040 4089 355 PMC5356908__F2 Immune cells in liver regeneration 718 727 4615 3383 6774 PMC5362541__F2 Inhibition of cancer antioxidant defense by natural compounds 9978 9817 8452 PMC5362592__F1 Different pathways induced by ALS proteins converge on translational repression 2521 83939 6647 4131 5879 PMC5364150__F7 Shigella modulates the innate immune response in epithelial cells 7186 7189 4193 PMC5364818__F2 Canonical and Noncanonical Inflammasome 4615 114548 8772 6772 7099 PMC5366285__F9 Cartoon illustrating a novel signaling pathway for the coordinated regulation of Rho and Rac signaling in epithelial invasion 6010 1398 80005 9815 PMC5369987__F4 Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis 9586 6517 8660 8471 PMC5369987__F5 Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis 90550 5350 857 858 859 613 952 3630 3643 5140 4852 PMC5370457__F1 Mechanism of signaling transduction of vascular permeability 7124 998 387 79083 PMC5372848__F1 Activation of the RAS/ERK and phosphoinositide cell signaling pathways following the binding of cell survival signals to receptor tyrosine kinases (RTK) 5728 5163 7249 7248 PMC5378159__F3 Synthesis and metabolism of oxysterol modulators of Hh signalling 1717 1581 1593 3290 133688 PMC5378352__F6 All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma 5915 5914 596 3791 2321 PMC5378756__F1 The activation, amplification and regulation of the complement system 1356 718 2271 2273 727 PMC5380184__F2 Related cell process and diseases with potential disease biomarkers induced by particulate matter visualized by Pathway Studio 51024 10059 1543 3458 4968 4599 7124 3397 140809 5154 2730 652 1437 3576 8614 3398 7040 4091 260431 PMC5384880__F4 Differential expression of proteins in the dorsal hippocampus generates specific network interactomes in ENT1−/− mice 644150 8522 10109 10092 6843 5050 9217 4355 8936 9465 54622 10788 4720 1465 4155 10409 5837 6285 4744 4747 5532 5530 4129 4710 4741 9118 4697 59283 5534 2572 4685 871 3897 2891 3241 140679 1345 6538 PMC5384880__F5 Differential expression of proteins in the nucleus accumbens generates specific network interactomes in ENT1−/− mice 997 6572 11183 83939 7419 6506 1103 10591 3776 5354 9381 4900 7416 2030 2697 8878 27344 2319 5179 2534 7189 55824 5122 23385 5173 8678 7070 5126 23433 23762 9774 PMC5384880__F8 Physiological development-functions associated with the dorsal hippocampus and nucleus accumbens of ENT1−/− mice 4900 84062 961 55799 79068 2030 6571 102 1103 43 2643 2534 10675 85358 1476 482 1622 6531 5611 253782 2697 10814 9379 63971 3760 2917 18 2824 9283 2891 4129 4128 3897 2572 8841 4082 4125 2563 5532 5582 9479 10636 1185 23417 5534 4747 477 9378 6342 2173 5791 64805 140679 8936 53616 57084 7416 9672 10846 7070 6604 6536 5354 6572 5887 19 6616 201780 114789 6197 80036 23657 6506 7419 PMC5386520__F2 Gas6 and TAM receptor signalling 572 2885 7301 558 2621 8440 6774 PMC5386709__F7 Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells 2896 545 7249 5728 PMC5388765__F1 An integrated network for phenylpropanoid regulation in the grape berry 4602 1312 5212 2077 PMC5390360__F2 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway 1977 1975 3099 2932 2475 7038 4193 572 596 9706 847 7249 PMC5390360__F3 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway 2539 7249 7248 6009 8408 1975 PMC5397662__F2 A simplified diagram showing the major steps in short-patch base excision repair pathway 3980 5423 7515 PMC5404269__F8 CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue 1573 3725 383 PMC5405066__F7 Hypothetical mechanism of action of BoNT/A is achieved through the modulation of TLR2 and SNARE proteins, and minocycline occurs through the modulation of p38 and MMP9 in glial cells 7099 3603 3569 3586 10068 PMC5406709__F1 PI3K pathway targeting agents in development for the treatment of prostate cancer 5728 7249 7248 PMC5409051__F5 Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats 2542 747 51378 79603 3645 5375 8605 65057 85451 2950 PMC5412778__F2 Neural ectoderm and neural crest specification in deprivation of the external signals.A 22943 6657 4086 5015 5080 2636 5077 7545 145258 83881 64321 3170 79923 1045 3855 PMC5415769__F3 RICTOR is upstream of multiple canonical pathways 253260 581 528 523 1347 9114 729 4701 7385 4709 7384 4725 10312 5687 6389 5692 5700 1345 1340 PMC5417569__F6 Transcriptome analysis of muskrat scented glands degeneration mechanism 4086 4089 3458 4091 4092 7124 9978 8454 6500 4052 4087 4088 6667 387 10468 5308 4838 PMC5421298__F5 Gene expression changes in the Wnt/Beta-catenin signaling pathway 64321 5467 4089 894 1387 3725 8607 4609 8626 8945 8312 2932 5567 25805 147111 5176 64840 1856 27130 387 5578 11211 5331 4775 818 PMC5428311__F3 Summary of the major global regulatory responses of S 6688 1896 5805 PMC5429547__F3 Differentiation of naïve Th cells into Th2 cells 64806 2625 942 940 941 1493 90865 PMC5430761__F9 Pathway showing role of Ror1in promoting tumor-cell growth, 1956 2065 4919 2885 1398 4920 5728 3716 3717 6774 PMC5431483__F1 PI3K/Akt/mTOR signaling pathway and pharmacological compounds used to modulate its activity 5728 2932 7248 6009 PMC5433957__F1 Positive and negative effects of GPC3 on its two main signaling pathways 2719 374654 51684 2736 2737 2735 1499 3725 1386 2002 6772 4089 PMC5434066__F8 Schematic diagram of Bc-specific induction of regulatory T cells via suppression of mTOR signaling pathway 50943 6774 6446 2625 PMC5435887__F1 Main genetic and signaling pathway alterations in UMs and CMs 3815 4763 2776 5922 4893 5332 7204 382 5728 6010 5879 80243 673 4082 2475 8314 PMC5436942__F4 A) IPA analysis suggests the involvement of signaling by ITAMs (immunoreceptor tyrosine-based activation motifs) in the FcGR pathway at 24h 2268 5829 10097 5296 PMC5442467__F8 Summary of the impact of keratins on the Notch1 signalling pathway 23493 23462 4851 PMC5445212__F1 Endosomal transport channels and regulation of lipoprotein-derived cholesterol in hepatocytes.In many models, it was thought that cholesterol from all sources would enter a common regulatory pool before subsequent trafficking and regulatory steps 3949 19 22937 3156 39 64241 64240 PMC5448626__F7 Possible schematic model of SNIPER(TACC3)‐induced death in cancer cells 331 324 10460 999 7494 PMC5449407__F7 SAR signaling in maize inflorescence based on DEG analysis 4015 4881 790 PMC5449449__F2 Integration of metabolic and fatty acids (FAs) metabolizing enzymes pathway in mitochondrial dysregulation, fibrotic hypertrophy, and chronic inflammation 3667 2308 4015 PMC5451860__F1 Role of WNT/beta-catenin pathway on aerobic glycolysis in gliomas 4040 4041 1499 3939 PMC5451860__F2 Opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in gliomas 1499 4609 3939 PMC5453186__F3 Clostridium difficile infection 3553 3554 114548 7100 4615 7099 10392 PMC5453942__F4 Map of DEGs in Oncopig STS cell lines and their functions within the TP53 signaling pathway 1029 4193 7157 595 1026 1021 5728 2475 3479 891 2810 9133 55240 85417 10912 51512 3486 5366 64065 27244 836 PMC5454035__F1 Regulation of autophagy by nutrients and hormones via the mammalian target of rapamycin (mTOR) signaling pathway 3667 5337 7249 7248 9776 60673 6009 7405 8408 9706 545 PMC5454924__F1 Schematic presentation of ROS scavenging pathway in chloroplasts 847 5091 57716 PMC5457463__F3 Phosphoproteomic analysis of CCL2 treated DCs and confirmation of relevant signaling pathways 6347 729230 26086 998 5336 8826 387 1399 118 6093 29109 PMC5463201__F3 Examples of NOX signal transduction 27035 50507 79400 3717 4313 1977 6774 5163 3566 PMC5464836__F9 Combinatorial treatment with polyI:C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells 3717 6774 7098 PMC5467017__F8 Working model portraying the effects of WNT/Beta-catenin signaling in PTENWT melanoma cells under nutrient starvation conditions 5728 1499 324 PMC5474494__F2 Phagocytosis mediated by receptors 8544 54209 51135 6850 998 PMC5482648__F8 High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin 5725 2017 6714 PMC5487527__F3 m6A is involved in viral replicationSchematic representation of the intersection between m6A pathway and viral replication 54915 51441 253943 57721 56339 54890 79068 PMC5487699__F2 Regulation and execution of the autophagosomal-lysosomal degradation pathway 9140 10533 83734 120892 9474 65018 64422 PMC5489557__F7 Mechanism for PE’s effects on hepatocellular carcinoma cells 22926 83939 468 PMC5489807__F1 Activation pathways for canonical and non-canonical NFKB signalling 7124 4050 4055 8772 7186 10454 23118 257397 5971 5970 PMC5490603__F1 Activation of Toll-like receptor (TLR) signaling pathways is mediated by a complex array of proteins 7096 7097 10333 7100 7099 114609 4615 51284 3654 3466 7189 54106 7187 23118 10454 3665 3661 3553 PMC5492501__F4 Myristoylation in regulating Fas/Fas ligand pathway during cytotoxic T cells activation: binding of a death ligand to Fas receptor leads to the formation of death-inducing signaling complex (DISC) 355 637 9397 4836 5062 572 581 8772 PMC5495885__F3 MiRNA discovery 81693 6497 4091 998 7030 8928 860 4838 3665 145258 3196 2885 57154 7421 5308 PMC5498621__F6 Examples of subnetworks in network reconstructed from injured swine brain treated with VPA 4760 6447 339983 9572 9796 1113 22983 23040 836 4741 2649 8851 23500 4744 6855 4747 9705 146664 64902 6622 9118 3375 93377 23026 70 347733 4209 5396 7057 4208 4794 5629 1759 5467 5649 2002 2904 429 10716 650 7432 6663 6347 6598 1462 23411 3815 2252 7018 597 7852 7494 56062 PMC5507898__F8 Hypothetical model for the role of ASXL1 in cell cycle progression through the cooperation with AKT1 and EZH2 171023 1017 2146 PMC5509646__F6 The regulatory network of lipid accumulation with significant characteristics 948 2167 123 22800 22808 2246 PMC5511499__F4 How is the Brain Renin-Angiotensin System Regulated? 1636 183 4041 1499 PMC5511947__F1 The downstream signaling cascade initiated by a hypoxic microenvironment 117581 7291 9839 6935 79923 6657 999 960 1000 9429 7852 648 4072 PMC5512170__F3 Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks 81609 55737 51699 23307 PMC5515284__F7 CanProVar 2.0: an Updated Database of Human Cancer Proteome Variation 1017 472 545 355 572 4609 836 4193 64065 7249 5728 64326 PMC5519008__F2 lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites 84890 100 54363 2752 1896 4118 4199 4200 759 1431 11113 PMC5520734__F7 Schematic diagram of G0/G1 phase arrest and ROS-dependent MAPKs pathway in which furanodienone induces cell growth inhibition and cell death in CRC cells 595 1021 1019 841 581 842 PMC5529882__F3 Detailed molecular network of pathways of the cell cycle (Kyoto Encyclopedia of Genes and Genomes ID, has04110) 9126 5885 4089 6502 4609 699 9184 5111 1022 1017 990 1869 PMC5532371__F8 A possible pathway for pre-miR-199a-mediated regulation of HSV-1 secondary envelopment 998 375 57584 PMC5535015__F1 NPD1 inhibits apoptosis during UOS 7186 330 8772 8717 PMC5541421__F4 TREM2 signaling and function 348 4049 5066 5091 54209 6850 1236 1499 PMC5541666__F3 Systematic analysis of key factors in the mitochondria-associated innate immunity pathway, using acute starvation of human SH-SY5Y neuroblastoma cells to reveal the transcriptional regulation of stress responses and their dependence on PINK1 65018 57506 8717 55669 3437 3433 3434 3661 3665 91543 PMC5543755__F4 Merged mouse and rat network (mapped to human proteins) and overlapping Reactome pathways 64121 80243 58528 10101 1431 80224 26502 717 886 4842 22927 1813 4915 6780 23237 55711 2060 55040 2475 PMC5543755__F5 Protein complex analysis 23237 10818 2353 9146 4099 22905 3739 9419 1741 1740 1742 23316 100187761 PMC5546429__F8 Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice 2475 627 1020 PMC5548098__F1 The major pathways of Cu distribution in human cells 10063 475 9973 6647 540 PMC5548184__F4 Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide 5764 1958 29941 3315 5371 572 666 355 4067 81693 5640 8029 5156 5641 3985 1512 83734 326 14 60528 7328 93100 2626 5598 353 6284 4846 348 4547 384 58488 351 5552 6252 4204 6230 11113 4036 6948 23380 10243 85004 1822 1601 5270 PMC5550366__F1 Revisiting the Role of Wnt/Beta-catenin Signaling in Prostate Cancer 324 367 4609 999 PMC5550862__F8 Role of SDC-4 in the regulation of the integrin and FGF signaling pathways 717 595 1017 PMC5555796__F2 Metabolic Disorder Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism 627 2539 5226 2821 5209 2147 142 2937 2597 1491 2739 47 5091 2744 65018 4967 23530 PMC5557744__F11 Schematic summary of the interleukin-6 (IL-6)/STAT3 signaling pathway, highlighting its central role in regulating the expression of multiple genes and cellular functions in metastatic breast cancer cells 595 581 6774 3383 PMC5559174__F2 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 3643 6247 5163 7248 7249 253260 5091 6009 2475 1975 1977 6010 1999 6194 PMC5559174__F3 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 1950 4803 4049 7039 4055 958 920 10010 7186 7189 114609 4615 3932 8772 8717 7535 7334 5336 7335 23118 257397 84433 10454 5971 2932 3065 6908 PMC5559174__F4 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 1373 54205 6389 7846 5481 5915 84790 22933 23410 51547 7088 3062 10376 5914 3416 33 4704 8213 7157 23409 2309 1499 293 5468 2547 23411 1869 7249 167227 5925 5934 5933 3091 3297 142 PMC5559174__F5 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 3643 840 4361 2885 472 100506742 2512 637 85451 7314 4026 3725 4094 5640 468 5479 641 1356 3146 3206 7412 3383 6401 2056 4282 405 PMC5559174__F7 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 1398 867 3667 2534 6010 2922 4193 85451 2308 572 596 472 545 4149 4609 672 581 54205 595 5933 51176 6929 6925 637 51684 27148 6714 8772 1616 23385 355 914 PMC5560141__F2 The EGFR signaling pathway involving CEMIP mediation 1950 57214 3084 6714 PMC5568783__F2 PERK arm of the unfolded protein response 83939 7494 581 596 PMC5570638__F1 Mammalian target of rapamycin pathway 3479 3091 7249 7248 PMC5580487__F1 Inhibition of apoptosis by hepatitis B Virus (HBV) infection 958 8717 7186 6714 8772 1621 572 5728 5966 5971 3725 317 PMC5584221__F9 EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway 6714 1003 1499 PMC5584530__F8 Cell surface HSPGs consists of a protein core linking several linear heparan sulfate (HS) chains 1490 1499 324 1024 4040 PMC5585656__F1 Proposed role of molecular and small molecule chaperones in proteostasis 3309 3312 3313 PMC5586504__F1 Regulation of Wnt Signaling by Protocadherins 4041 4040 8312 324 2932 5879 23002 1499 998 51701 6259 PMC5587989__F1 Hippo/YAP signaling pathway maintains the balance between cell proliferation and apoptosis 4485 9113 26524 PMC5587989__F2 YAP is regulated by various factors during hepatocarcinogenesis in addition to the members of the Hippo signaling pathway 28951 1432 8945 4162 PMC5589252__F6 Mapping the STK4/Hippo signaling network in prostate cancer cell 10207 126374 154796 5584 23513 1739 7161 23291 4771 6788 26524 7003 374 5515 174 3689 11186 2246 4092 4087 7040 7046 4089 151449 4086 85407 595 4609 51176 1855 11211 1499 6657 6591 10297 8312 329 60 10971 1495 23418 3993 10413 27113 23286 5054 2932 PMC5594548__F7 RNAi amplification, spreading and transcriptional gene silencing pathways 10419 162239 23381 23293 PMC5594744__F3 The MUST complex (MAGEL2-USP7-TRIM27) is important for the retromer-mediated endosomal protein recycling pathway 7874 5987 55737 PMC5595345__F8 Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage 5885 9126 10664 PMC5595898__F6 Terpenoid biosynthesis in M 4598 4597 2224 9453 PMC5596436__F7 Selected microRNA-target (cell cycle pathways) interaction data 9126 10055 4193 699 9184 5111 1022 983 1017 6502 4661 990 8317 PMC5607814__F1 AMIGO3 and LINGO-1 signaling in neurons.Both AMIGO3 and LINGO-1 are able to form a complex with NgR1 and P75/TROY (Mi et al., 2004; Ahmed et al., 2013) 84894 386724 4099 6010 PMC5607814__F2 Mechanisms of action for LINGO-1 and speculative AMIGO3 signaling in oligodendroglia.(A) LINGO-1 is able to bind to ErbB2 and prevent its translocation to the lipid rafts on oligodendroglial membranes 84894 2064 386724 1956 2475 PMC5609400__F3 The Shh, TGFB/BMP, and Wnt morphogenic signaling pathways 6469 6608 5727 51684 4040 4041 2932 324 23002 1499 6010 PMC5609723__F2 Aryl hydrocarbon receptor-mediated hepatotoxicity is a cumulative response to the overall burden of multiple disrupted pathways rather than a single adverse effect 5315 196 26291 PMC5613156__F3 NOD-like receptors control various forms of PCD in mammals and filamentous fungi 114548 317 51228 57495 7175 PMC5614756__F1 DJ-1 activates ERK1/2 signaling pathway 1843 2002 6647 7054 PMC5615147__F2 Regulations of Nrf2 by several factors 9817 196 405 3725 6478 PMC5615630__F7 RSV inhibiting NKTCL cells 6774 572 581 472 PMC5616168__F13 Schematic diagram for the ADTRP signaling pathway 84830 338 790 8503 PMC5622284__F4 Upregulated genes involved in apoptosis signaling at 1 day after a single dose of 2 Gy Fe ions 2242 4049 8717 572 4170 6955 6670 100187907 4609 PMC5622284__F6 Irradiated ECs differentially expressed proteins after X-ray exposure involved in caveolar-mediated endocytosis and cell-cell adhesion 2319 2318 5770 857 5216 378 7094 1000 1499 PMC5623591__F3 Central tolerance for B cells 613 973 930 974 695 5336 6850 5728 29760 2885 759 5894 3643 6786 2308 4609 PMC5628093__F2 Crosstalk between Panx1 and ligand-gated receptor channels 24145 6714 717 PMC5640978__F4 Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection 6347 6348 7124 6351 PMC5642988__F4 Hippo pathway in intestinal regeneration and disease 4485 60485 10413 1956 4280 PMC5642988__F5 Hippo pathway in intestinal regeneration and disease 4485 60485 9113 26524 1499 10413 PMC5642988__F6 Hippo pathway in intestinal regeneration and disease 4485 60485 9113 26524 55233 10413 PMC5649202__F4 Gene regulatory network (GRN) inferred for members from the TP53 pathway 4193 27244 1643 2810 7157 3732 317 894 472 637 545 64065 581 50484 3479 92344 10912 7249 4616 891 8493 7161 355 9133 9538 5054 54205 898 983 PMC5652738__F9 Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer 3082 1956 6774 PMC5660697__F1 JNK signaling pathway 7054 3146 1386 4088 PMC5661117__F8 Hippo pathway in mesothelioma cells 4771 9113 26524 60485 6010 4485 374 PMC5661483__F12 10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NFKB and (BIRC6-XIAP) complexes 207 7124 330 329 355 332 1647 3480 8717 8772 573 581 637 56616 331 57448 54205 4671 1676 PMC5662584__F4 Proposed mechanisms involved in in vitro anticancer activity of surfactin 173 1017 891 581 PMC5668426__F7 AGEs-Cyr61-VEGF pathway observed in this study 4313 4322 6774 6120 PMC5671526__F8 Schematic representations of potential mechanisms of PEBP1 in enhancing inflammatory response and neuron apoptosis after I/R injury 5037 3569 3553 PMC5671979__F6 miRNA-mRNA network 55898 5090 2353 57532 4214 6310 9135 6899 6597 5908 57616 431707 5900 79745 29970 9760 203447 4335 768211 50488 29068 60685 5139 1794 5025 57606 10076 2201 389 117178 204 7072 1665 55450 2773 54674 25842 81573 1982 57113 5428 170692 85480 54862 3660 3920 54677 55083 4038 28962 10637 55723 200186 28316 80333 9156 7532 10742 8408 22998 5252 79720 23637 23096 6996 26985 3002 7514 10664 395 283373 7431 7073 51119 205564 4651 214 83871 54542 255967 5213 1629 5989 10914 23122 4862 4097 102 54521 66000 80153 990 127845 5153 167826 5366 PMC5672637__F10 Schematic diagram for the functional mechanism of Aster glehni extract 47 3569 355 7038 3156 PMC5681673__F4 UV-induced H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway 9025 10075 165918 PMC5686148__F8 Working model 5347 995 2305 2539 983 1017 PMC5689582__F3 Increased transcriptional and metabolic capacity for lipid metabolism in the peripheral zone of the prostate may underpin its increased susceptibility to cancer 2222 6713 4047 1718 1595 7108 6307 50814 10682 6309 120227 1717 6646 1591 PMC5689670__F8 Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt/Beta-catenin signaling pathway 81861 100499166 1499 581 4313 898 4318 1019 PMC5693031__F7 Tight junction pathway overrepresented among Qki5 HITS-CLIP target genes based on DAVID-KEGG pathway analysis 64398 998 10207 2064 1499 1019 6010 5865 5872 8573 9863 5728 PMC5693733__F3 Melatonin and its metabolites act as radioprotectors on epidermal keratinocytes and melanocytes 1362 7507 7508 9817 847 PMC5698910__F1 Bile acid synthesis, signaling, and regulation in human liver 10858 1593 9023 9965 51302 9420 1582 4280 9294 PMC5701650__F1 STRESS ADAPTATION 1255 3297 10413 PMC5704268__F6 Schematic representing the in-depth molecular mechanism of the neuroprotective effect of DZ 847 2475 596 PMC5705453__F2 The role of ASK1 in endothelial cell 7124 637 581 PMC5706385__F6 Schematic model for ZJW extracts in inhibiting 5-HTR1D and attenuating Wnt/Beta-catenin signaling pathway 4041 1857 1856 8312 2932 1499 51176 6925 4313 4316 595 PMC5712312__F1 Synthesis of glucosylceramide (GlcCer) and its complex glycoshingolipid metabolites 4810 1674 57704 2629 51083 PMC5713242__F8 Cilia-dependent mTOR signaling 7248 7249 6009 PMC5714869__F6 Schema depicting the Peli1-mediated pathway following SAH 7099 4615 57162 PMC5715731__F9 Model illustrating the intracellular signaling pathway leading to cell proliferation and survival in response to NRG-1B treatment 2064 2065 627 2932 PMC5718814__F2 Molecular mechanisms of DNA vaccines 7098 3665 54106 4615 29110 3661 9447 PMC5725130__F3 Identification of hub genes related to silicone-induced immune response in rats 718 1431 613 324 5879 54472 29949 8772 3569 114609 3929 929 23118 958 114034 1513 54106 3792 PMC5727329__F2 DKK1 regulation of signalling pathways 1499 22943 4040 4041 10970 6259 324 387 PMC5727596__F2 Influence of chosen compounds/proteins on the Wnt signaling pathway which are under consideration as either potential therapeutic targets (continuous line) or potential therapeutic/adjuvant agents (dotted line) 182 79923 5058 22943 652 PMC5731927__F6 Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway 2735 581 596 PMC5732092__F2 Interleukin (IL)-17RA/RC signaling pathways 84818 7186 7189 7188 PMC5732234__F1 Toll pathway in fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse 4615 51135 3654 7189 PMC5733474__F2 Enriched PI3K/AKT signaling pathway, identified by Ingenuity Pathway Analysis based on 300 differentially expressed genes (nominal P values < 0.05) detected exclusively in both week 8 and week 12 topiramate (TPM) groups 5728 6237 4794 5528 7184 572 7249 7157 6009 79923 1499 881 2475 PMC5739687__F3 PPI network of proteins (A) up- and (B) down-regulated in renal oncocytoma 26056 25824 3045 100187828 6648 131118 25828 2671 3690 928 3685 2147 26520 131474 26517 10469 7450 1160 549 54927 1152 5095 26515 3326 2806 622 35 3313 116540 7019 10128 3421 81892 3418 23479 10939 23530 292 2548 6631 3030 50 55753 7417 4967 50808 5162 1431 2395 2720 336 10105 26355 291 4191 593 6389 10063 54205 1737 1743 335 7385 1340 11331 7381 5250 84545 6622 1738 10102 6205 3700 3958 27068 63875 388753 65003 7388 1337 27089 9296 64928 3482 1509 1345 55168 1350 51606 9908 6742 1854 28973 525 51142 8635 2950 56954 2878 6649 4522 1808 55268 10549 4695 4705 4722 30 5091 6472 1809 51292 471 4720 435 5106 51181 1962 23136 4715 4729 2023 9380 2037 4728 55748 501 4719 4726 54829 9414 5549 55349 23022 4969 3728 5721 5687 633 5576 9590 144100 338 1495 8502 1264 4057 4069 1265 4638 10901 1634 4357 6821 4237 7263 7171 1462 960 83660 5420 3880 3936 6191 302 4048 1508 259 6281 PMC5742900__F3 Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals 1733 3416 196 PMC5743625__F2 Epithelial PGR regulates multiple signaling pathways in the endometrium and transuduce signals via uterine epithelial-stormal inteactions 2624 5241 3549 5727 8643 9464 650 54361 1956 PMC5744080__F8 GF1 mechanism of preventing ox-LDL-induced inflammatory injuries through activating A20-mediated NFKB signal pathway 348 7099 3383 3603 PMC5745837__F7 Molecular interactions in the Akt/mTOR signaling pathway.IP3K: Inositol-triphosphate 3-kinase; PDK: phosphoinositide-dependent kinase; TSC: tuberous sclerosis complex; Rheb: Ras homolog enriched in brain; mTOR: mammalian target of rapamycin 2475 717 7249 7248 6009 PMC5746010__F1 Interactions of ALS/FTD associated genes with autophagy pathway 203228 5861 140775 55255 8408 9776 4218 60673 22863 29982 29110 10133 9217 55432 7415 PMC5751354__F1 Glucose metabolism in cells 2539 2597 5132 PMC5752449__F4 Shared and specific mechanism of four autoimmune diseases 7097 5879 54472 114609 10333 8772 4026 23118 7189 958 5132 1513 130749 3661 7187 7098 4615 PMC5752449__F5 The shared and specific mechanism of four autoimmune diseases 355 3630 3643 7249 7248 6009 572 2885 2488 1610 790 4313 998 1956 1839 9846 8213 PMC5752449__F6 Proteasome and ErbB signaling pathway 23237 6102 6185 3458 51371 867 367 1398 685 3725 4609 2885 2475 572 PMC5752873__F1 Wnt signalling pathways and their interactions 23002 324 387 1499 51701 6478 PMC5755497__F8a Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation 7422 5228 7423 7424 2277 2885 PMC5763573__F6 TGF-Beta-induced fibrosis signaling pathway 4087 4088 4089 4318 4313 PMC5766142__F6 Methylene-tetrahydrofolate reductase contributes to allergic airway disease 93408 2051 4160 4988 10734 5007 3927 2870 8079 4794 5600 55072 6137 7204 3581 51666 29933 246329 PMC5767254__F1 myomiRs and muscle mass wasting and atrophy pathways 8788 7528 317649 1978 7291 2475 2309 1499 7037 3479 3356 PMC5767254__F2 Exosomal microRNAs (miRNAs), proteins, and muscle mass wasting 51284 4615 7097 51135 3654 7189 9140 2309 PMC5768180__F7 Interferon regulatory factor 5 regulates B cell proliferation and cell cycle 5591 545 472 6502 7531 324 7532 991 7533 5111 7534 4355 1017 5933 4171 1870 51564 PMC5768892__F6 Gcn5−/− EBs becomes evident early during EB differentiation 3643 2887 6774 81848 586 2731 10797 6196 6723 4609 23057 PMC5770599__F3 Regulation of important signaling pathways by E3 ubiquitin ligases in CRC 1956 324 999 3845 331 6502 673 4193 983 1017 2475 PMC5774249__F8 Cellular model of insulin (and leptin) signaling via TRPC5 channel activation in POMC neurons 6786 7224 3717 9021 5163 5443 PMC5774495__F4 Osteoclast differentiation signaling pathway 3458 1540 7186 5879 1513 100187907 29760 6850 4286 10379 PMC5776718__F1 Overview of the L-lysine biosynthetic pathway in Synechococcus sp 5183 11113 4118 PMC5777317__F1 Regulation of the immune response by the aryl hydrocarbon receptor 196 9049 405 57491 PMC5777751__F6 Protein–protein interaction networks of differentially expressed proteins 1103 6955 2833 6714 PMC5784884__F5 Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study 6510 2171 948 95 2531 8443 8540 29933 2776 2932 351 23621 572 PMC5795380__F1 Protein subnetworks of Ras (the query protein) with Raf and ERK1/2 3845 8036 673 5894 5604 5863 5605 369 6654 PMC5795986__F3 Signaling pathways for melanin inhibition by NSC-CM 22943 1499 4286 4040 4041 PMC5796392__F6 Role of miRNA in the antigen cross presentation pathway 6772 84166 2923 5699 5698 5696 3312 PMC5796629__F2 ROS generation metabolomics, transcriptomics, and metabotranscriptomics 2056 2247 2934 2920 3479 793 596 348 213 4137 4353 7350 4842 4843 27035 387 1956 2335 1576 3356 3551 3606 8678 3565 730249 7432 7099 6863 6714 6648 3164 6622 5027 5925 5138 5467 5697 5663 5581 PMC5797541__F1 Representation of proteins and protein complexes involved in the “Autophagy – animal” KEGG pathway 5728 5478 7249 3091 7248 8544 64422 1509 1514 1508 4137 PMC5799178__F7 p38 mediates the transcription and the translation of E-selectin by modulating miR-146a and miR-31 3553 7189 2624 PMC5800973__F4 KEY ROLE OF EXTRACELLULAR VESICLES IN THE METASTATIC PROCESS 975 7852 960 355 4318 PMC5802154__F8 Intracellular signaling mechanisms that induce epithelial mesenchymal transition during CSE-induced aberrant EGFR activation in human RPE cells 6120 6850 6714 7040 PMC5804098__F4 Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation 26227 29968 5723 5106 57103 PMC5807036__F2 Tumorigenic proteins significantly upregulated in the IMR-32 cells mapped to the MYCN proto-oncogene, bHLH transcription factor (MYCN) pathway 285 3091 6720 6667 3897 3643 1977 4609 4613 4254 22937 3562 2313 PMC5808733__F7 Activation of the JAK-STAT pathway by viruses and the biogenesis, fission and fusion life cycle of mitochondria 3716 7297 6772 6773 10379 3454 3455 PMC5808733__F1g Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission 7297 3716 6772 6773 10379 3454 3455 PMC5808955__F1 Schematic overview of the effects of Saccharomyces boulardii CNCM I-745 on enzymes within the small intestine 23269 6476 5805 2885 1610 PMC5809980__F4 Diagram illustrates the dominating signaling pathways involving Sal- induced autophagy 57761 7248 7249 6009 10533 2475 64798 PMC5812256__F1 Bile Acids in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis 570 1593 9420 1582 2264 9965 PMC5812543__F1 Isoprenoid formation 5132 3422 3652 PMC5817809__F1 TKI-induced regulation of glycolytic pathway 4609 3098 3099 3101 5208 57103 2821 5213 2203 5214 8789 5211 230 229 226 7167 5223 5224 2023 2026 2027 3939 3945 3948 3091 PMC5818603__F1 Chromatin structure of human and mouse telomeres 1786 1788 1789 6839 9869 80312 200424 54790 1616 1200 55183 546 10714 201516 PMC5819357__F1 Combinatorial CRISPR-Cas9 metabolic screens reveal critical redox control points dependent on the KEAP1-NRF2 regulatory axis 4118 229 7086 6888 3098 5211 2539 5226 3099 3101 5214 8789 230 9563 22934 7167 6120 2645 5213 226 5160 1738 2805 4199 5161 5162 8050 1737 2806 2597 5224 5313 4200 4190 26330 2023 3939 5091 4191 92483 5230 5232 2026 2027 3945 5223 3948 PMC5819688__F6 Anacardic acid and signaling pathways 5119 2669 472 PMC5819875__F2 Wnt/Beta-catenin signaling during early vertebrate neural development 64840 4041 4040 324 1499 7008 4609 389058 PMC5819891__F4 Homeostatic Systems, Biocybernetics, and Autonomic Neuroscience 4922 6693 5978 PMC5822656__F1 MiRNA biogenesis, function in cytoplasm and nucleus-cytoplasm transport 27161 29102 54487 167227 PMC5822798__F1 Activation of TLRs during heart failure 3146 3371 4615 54106 7098 7189 29110 3661 7097 7099 PMC5830721__F5 HIF-1 signalling pathway is enriched in proteins containing labile disulfide bonds 6774 7099 7428 8453 2444 7037 1977 7010 2475 226 3795 3939 3569 5163 PMC5831833__F1 Schematic overview of the autophagy pathway and target points of its modulators 6009 22863 9706 9776 9140 9474 64422 PMC5833125__F2 Signaling networks in osteoclastogenesis 126014 54209 2885 10451 6850 7186 7189 9846 7006 100124696 695 29760 23118 10454 4286 4772 PMC5837509__F2 Apoptosis and p53 signaling related to Cr(VI) exposure 637 596 572 2021 4170 27429 581 54205 56616 6093 2620 790 472 3240 100187907 1071 1283 PMC5844108__F10 Different metabolic responses in acquiring FK866 resistance in CEM RES (a) and MDA RES (b) cells 93100 23475 3939 10135 PMC5845129__F1 Schematic diagram for innate immune response against influenza A virus (IAV) infection 3466 7297 4615 7098 51284 57506 3661 3665 PMC5851248__F5 Summary of excitotoxic pathways, mediators and potential therapeutics 5728 1612 24145 PMC5854685__F8 Pathway from hippocampal molecular defects to AD neurotoxicity 3419 10814 9588 10935 PMC5855561__F9 Working Model for regulation of prostate cancer 8832 196 3553 1545 PMC5855617__F1 Cancer-fighting mechanisms of BP 558 6657 2146 PMC5863502__F2 Beneficial effects of immunobiotics on the antiviral innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells 3439 7297 3716 6773 7098 57506 3661 51660 PMC5864929__F4 Arachidonic Acid Metabolism Pathway 873 100 9536 6916 5742 247 4118 240 4049 2678 PMC5867882__F2 Mammalian Hippo pathway 960 79633 4771 122786 4485 60485 11319 9113 26524 6010 23513 332 374 7003 8463 7004 7005 847 PMC5868510__F5 The molecular mechanism by which miR-134 aggravates atherogenesisMiR-134 downregulates ANGPTL4 expression by directly binding to the 3′UTR of ANGPTL4, leading to increased expression and activity of LPL 406924 51129 4023 4035 PMC5869864__F3 mTORC1 as the main gateway to autophagy 7942 8408 9776 60673 55626 PMC5871764__F1 Notch pathway 5986 1856 8850 1387 8650 4242 151636 113878 3280 388585 23462 5663 1487 1488 3065 3066 23385 83464 PMC5871764__F2 Notch pathway 5986 8850 1387 8650 3955 151636 3280 388585 23462 5663 1487 1488 23385 83464 3065 3066 PMC5874524__F8 LGM2605 inhibition of asbestos-induced NLRP3 inflammasome activation by blocking asbestos-induced reactive oxygen species (ROS) generation and activating the Nrf2-ARE pathway 3553 8452 9817 114548 7295 1728 PMC5876306__F3 MYC and HIF-1 regulate glucose metabolism 2821 4609 2597 3939 PMC5877728__F1 Overview of the stress-activated protein kinase (SAPK) pathway 23043 10454 7535 PMC5878942__F3 Physiology and role of irisin in glucose homeostasis 2308 10196 5105 4513 355 PMC5881172__F1 Unfolded protein response 22926 6668 6667 7494 468 PMC5882331__F2 Therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer 545 472 4193 57103 9997 7508 581 PMC5882662__F6 Metabolic pathways related to the differential metabolites identified in the BDE-3 groups 95 1376 2695 PMC5883056__F7 Signal transduction Pathway analysis of the possible drug target FGR, ESR1 and GCRA and their localization 2249 2260 2099 1312 217 3479 PMC5885411__F3 Pathway analysis illustrating differential gene expression and association between gene nodes 6790 4751 699 891 9793 1062 1063 10403 4000 PMC5889941__F1 Alterations in glucose and glutamine metabolism contribute to tumor growth and proliferation 26227 3939 2744 PMC5891223__F5 Epidermal Growth Factor Receptor Signaling to the MAPK Pathway Bypasses RAS in Pancreatic Cancer Cells 1950 998 5058 1956 PMC5894239__F5 Functional network overrepresented in the list of differentially expressed miRNAs in response to infection of bovine macrophages with Streptococcus agalactiae strain (a) ST103 and (b) ST12 100126333 367 56246 407008 PMC5901847__F1 Diagram of signal pathways and molecules participating in the preservation of the pluripotency state and reprogramming 367 1499 1950 3976 2885 6295 324 51684 842 572 6657 6418 6608 PMC5901981__F3 Protein Kinase C: Perfectly Balanced 717 11140 5163 5300 PMC5902023__F1 Mammalian isoprenoid biosynthetic pathway with associated inhibitors 2224 3652 6010 PMC5912671__F2 Fanconi Anemia 472 545 3458 6772 PMC5914062__F2 Schematic model illustrating the relationship between glucose metabolism and radiation resistance 5163 3939 6774 407010 PMC5915419__F1 Molecular association of Wnt, MITF, TYR, and DCT 1499 2932 4286 1638 PMC5915650__F7 Proposed mechanotransduction mechanism 650 1499 860 6010 PMC5919976__F4 Proposed integrated model of BTN3A1 modifications induced by phosphoantigens and leading to the antigenic activation of VG9VD2 T lymphocytes 11119 11118 5493 388 PMC5925453__F7 Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis 374 1950 3082 2065 1956 2064 64866 1969 6714 5829 3717 4067 6774 10413 9113 26524 2475 9686 7003 PMC5927447__F10 NF2 signaling pathway plays a pro-apoptotic role in Beta-adrenergic receptor stimulated cardiac myocyte apoptosis 4771 4485 581 PMC5928365__F7 Ror2‐dependent noncanonical Wnt signaling 4920 6478 1499 4040 4041 PMC5928601__F3 Arachidonic acid and linoleic acid metabolism signaling pathways 4057 4049 4050 3976 PMC5932138__F6a Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition 718 1195 2271 721 727 PMC5940272__F1 Alternative pathways of type I IFN induction during M 7099 64127 115004 29110 3661 3663 PMC5940296__F1 Latest advances in the interplay of physical and biochemical signaling pathways leading to transcription in the tumor microenvironment 7448 9908 5979 999 1499 2932 5728 8900 3383 7412 4609 8313 6935 PMC5941588__F9 Comparison of networks affected by FA or O3 exposure in females at different stages of the estrous cycle 23023 4286 22944 57099 54619 7127 4609 PMC5945848__F8 P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy 6667 3315 5027 5594 207 5562 1311 2932 51100 8408 PMC5945923__F1 Cross talk between E2–estrogen receptorA (ERA) signaling pathways and circadian rhythms in breast cancer 6714 8864 406 4313 7018 9575 PMC5948853__F8 A schematic of the model of crosstalk between STAT1 and TGFB signaling pathways 4089 4092 3716 3717 PMC5948914__F2 Gemcitabine pharmacologic pathway 9154 2030 3177 9153 89845 9429 10057 64078 55315 978 1633 1635 92797 23649 6240 9150 6241 5426 7298 5430 50484 4693 PMC5956756__F7 Proposed mechanistic scheme: miR-29c suppresses breast cancer by the TIMP3/STAT1/FOXO1 pathway 407026 100187761 7078 6772 2308 PMC5958474__F8 Oxygen sensors, VEGF pathway regulators and stem cell master regulators regulate DNA damage response gene expression in human tissues 3091 7422 7423 7424 5228 2321 3791 2324 947 3815 6657 5460 4609 9314 PMC5962695__F1 Extracellular matrix (ECM) in structural and functional synaptic plasticity 6678 5091 4314 4313 1600 2747 7436 PMC5963348__F7 Schematic model for SIRT3-induced autophagy and its underlying mechanism in SH-SY5Y cells following rotenone treatment 6098 23410 2475 PMC5964095__F10 Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1A signaling pathway 3099 2475 3939 PMC5966875__F1 Synthesis and metabolism of common bile acids in human 1593 80270 8213 978 PMC5971270__F5 IPA identified “LXR/RXR activation” as the canonical pathway in the ESPs of TC-1 cells with the highest predicted potential/significance affected by the treatment with caerin 1.9, predicted based on label-free quantitation 335 23643 948 3661 4023 64137 116519 3603 847 PMC5975185__F1 Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes 9896 29110 3661 PMC5976735__F3 Main signaling pathways involved for 12 miRNAs differentially expressed after exercise from EVs purified from rat’s serum 5447 50975 27040 4117 PMC5976976__F4 Hypothetical diagram showing target sites for the action of curcumin (diferuloylmethane) in signal transduction pathway 351 596 3603 1728 9817 4094 PMC5979333__F2 The NF2/merlin signaling pathway 960 10207 64398 2475 7248 154796 6009 7249 4485 9113 26524 999 60485 1499 9730 4609 389421 PMC5979467__F2 Role of survivin in caspase-mediated apoptosis 355 56616 4397 572 637 331 1431 8772 PMC5983650__F9 Bornyl cis-4-hydroxycinnamate-induced apoptotic pathway 581 637 811 572 83939 468 PMC5987716__F2 SOD-dependent ROS signaling in mammalian cells 6649 6647 57716 847 6648 7018 3297 5728 6714 PMC5992473__F9 Schematic Illustrates a Model of miR372 Promotes Liver Cancer Cell Growth by Upregulating erbB-2 through Enhancing YB-1 via Targeting for PTENmiR372 accelerates malignant progression of liver cancer cells in vitro and in vivo 442917 5728 10664 728655 2064 1499 1017 6925 PMC5992820__F1 Simplified schematic diagram of the pathways described in this study 2064 2065 3480 3667 5163 7248 7249 PMC5993136__F1 Regulation of lipid metabolism in cancer cells 948 2475 22937 2194 8694 84649 55902 7038 6576 47 38 3156 19 3949 PMC5996928__F5 Molecular signaling pathways involved in astrocyte reaction in AD 6774 7018 3606 718 PMC5999788__F2 Integration of actions of PKD1 and PKD3 in cardiac energy metabolism—a hypothetical scheme 948 5312 5310 51564 10014 6714 PMC6003288__F2 Luteolin inhibition of receptor-mediated tumor progression.Notes: Involvement of luteolin (green) in modifying processes necessary for metastasis 5728 2932 2309 2475 1499 PMC6003288__F3 Luteolin-mediated extrinsic and intrinsic apoptosis in breast cancer.Notes: Illustration abridging the involvement of luteolin (green) in purposed apoptotic pathways 8772 581 355 PMC6003316__F5 Genes of gossypol pathway enzymes and their expressions 9961 3652 4598 PMC6005692__F11 HIV-1 gp120 up-regulates BDNF expression in BV2 cells via Wnt/Beta-catenin signaling pathway 4040 4041 324 847 7008 PMC6005849__F4a Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions 2885 7054 3458 1540 7124 2274 5879 1513 6850 100187907 4286 8480 PMC6005849__F7 PI3K–AKT pathway perturbation in response to treatment of interleukin (IL)-6 stimulated osteoblasts with resolvin E1 (RvE1) 1977 2475 7249 6009 1975 5894 8178 5879 613 930 5934 5728 150365 4193 10682 8544 572 PMC6008255__F1 Different Wnt signaling pathways 324 2932 1499 7008 57216 5754 23002 5879 6010 4041 4040 PMC6010849__F10 Schematic overview of Nrf2 signalling crosstalk to both Wnt3a/B‐catenin and AMPK pathway in COPD/emphysema 89780 1728 260431 PMC6014344__F2 Molecular mechanisms involved in induction and progression of podocyte EMT caused by hyperglycemia 3611 1499 790 4092 PMC6021456__F7 Interaction of LBR, Rab5, Nup205, and NXF1 in the PI3K/mTOR/AKT signaling pathway 3480 3667 5728 10482 5163 3930 6009 7248 7249 29904 1977 1975 6194 PMC6021761__F3 Discovery of IDO1 inhibitors: from bench to bedside 169355 3620 8564 196 8942 PMC6023839__F5 Regulatory Network and Crosstalk Analysis for Gene Set(A) KEGG pathway network formed by relapse gene sets 6383 5564 85021 10389 8531 2887 8843 56675 23228 9938 4311 2993 87 115 3055 664 64798 7430 84263 1525 2778 1791 8660 4067 5332 2920 6351 6790 8850 4671 4603 1508 5530 10282 324 2122 4853 5813 4939 11221 27101 9126 9839 175 4353 2581 1510 950 5783 8091 1371 4000 6907 6659 1053 8504 4609 4211 9969 55635 64750 7490 7050 4976 196 3725 3684 79684 4140 64127 4613 4999 467 5277 3728 5090 3002 23389 3626 10449 57154 PMC6026536__F1 Reactions and enzymes of proline metabolism in higher organisms 5625 29920 4942 PMC6027367__F1 Unfolded protein response and NFKB signaling 83939 7186 467 468 7124 PMC6028720__F3 Compound–target–pathway subnetwork of 12 compounds relating to AD 5644 22933 5328 79915 1111 3363 8843 23410 1812 3832 6532 1813 1137 136 6571 1139 8989 2152 1141 1565 1956 54106 1559 51053 5602 1723 79001 4129 10919 23621 1432 4128 9429 9453 4780 2932 4598 1576 4137 1588 1610 1548 5743 5742 5770 246 771 3028 873 9212 142 596 3292 80351 3248 9536 51426 8658 4170 1017 1991 3293 50507 4363 6530 590 5243 10188 1066 11168 PMC6028759__F1 Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus 7474 324 1499 6425 PMC6029659__F6 H2S targets key host factors and viral steps to perturb replication of enveloped RNA viruses 3661 9817 6667 8717 PMC6030166__F6 Combined network analysis of metabolites and lipids 10018 4609 5743 166929 3931 348 8824 29920 3106 3107 7965 5685 7314 150465 3613 2346 65057 9255 10056 5290 7316 2673 57505 4143 5831 440 5478 10606 29028 18 23152 47 2571 162417 6513 2806 2730 7083 6389 2184 81889 5500 3162 2805 2729 8604 PMC6030166__F8 Central carbon metabolism in cancer 6510 8178 23410 51548 4609 2744 2064 3416 4967 47 5208 2645 3939 4190 57103 9123 5728 PMC6036835__F5 KEGG pathway (FDR < 0.05) enriched by the 289 differentially expressed genes in drug group compared to model group 59284 125965 1347 528 4697 6167 6210 6164 51264 51069 54460 PMC6036887__F2 Butyrate suppresses colorectal cancer development 581 6667 8829 PMC6039966__F3 The AhR genomic pathway 196 6714 405 57491 PMC6041267__F8 A schematic model of mitochondrial distribution regulated by the Arf6–AMAP1–ILK pathway 25865 55288 22906 66008 3611 382 PMC6044101__F6 Spleen regulatory networks 29106 129804 1950 80381 259236 23467 54716 154881 117247 22904 55108 8739 50515 10776 386682 2695 8945 6483 89874 23457 55432 5427 6241 8882 4609 10124 22974 51665 136051 3064 3458 1265 596 PMC6044892__F8 Speculated biosynthesis pathways of glycosylated products elongated on a saccharide primer 4936 1431 51083 PMC6046223__F8 Signaling pathway which miR-21 can regulate multiple functions in astrocytes 4087 4088 5728 2475 PMC6056413__F7 Schematic diagram showing proposed pathway through which cyclic mechanical loading regulates primary cilia expression to control tendon matrix turnover 10013 6418 4312 4322 PMC6056925__F5 B cell receptor signaling pathway and network of anti-inflammation 933 5777 4067 7410 973 974 3635 50964 3265 5604 8915 930 6236 5781 1020 5335 3312 7532 6714 3055 1234 3925 4318 613 695 203 PMC6068089__F9 Schematic depicting neuroprotective roles of BRCA1 towards I/R injury 672 2879 2729 6648 PMC6073096__F4 Simplified DNA repair pathway diagram 6741 472 545 672 675 5888 PMC6073226__F4 Mechanism of modulation on sphingolipids by chrysin (A), curcumin (B) and genistein (C) 6611 8877 56848 PMC6073502__F1 Ingenuity pathways analysis (IPA) functional network generated for data of NH0-, NH3-, and NH7-groups 9615 6721 5609 5602 4224 6416 3315 6038 9261 7157 3849 3553 6612 30968 2353 3569 54205 50487 3958 1410 3484 3643 11034 706 5641 1431 7416 4190 6834 3098 PMC6073502__F2 Proteins with influence on cell-death related signal transduction (green/light green: up-regulation, red/light red: down-regulation) 2023 10576 2539 9615 213 3315 119 3849 60 5641 7416 4190 30968 4224 3921 2923 7001 5037 5520 PMC6073502__F4a Time Dependent Pathway Activation of Signalling Cascades in Rat Organs after Short-Term Hyperoxia 6622 10096 7846 6612 8650 6774 2805 27230 2665 5914 5520 2923 5861 6890 10381 30968 7001 3921 5162 6175 1327 1537 4190 682 4191 4259 3315 10576 10327 4282 6767 2023 95 5641 2778 6569 38 2203 229 4224 9615 10380 51773 PMC6073700__F5 GHR-JAK2-STAT pathway inhibition mediated by PTP-1B, SHP-1, SHP2 and SIRPA1 3717 2885 6774 8651 PMC6076434__F8 Schematic view of pathways regulating IL-1A expression in hRPE cells 7099 7097 4615 114609 3661 3665 3553 PMC6077207__F8 Schematic presentation elucidating proposed mechanisms that TLB protects PC12 cells against oxidative stress-induced injury 9817 3418 6648 23410 PMC6079386__F14 Gga-miR-302b-5p and gga-miR-302-3p miRNAs 7227 144455 26524 51701 2005 2147 7157 PMC6080592__F3 Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data 1610 5621 581 2 3635 5009 5328 4942 219 3717 100506742 5791 5625 58510 2149 7056 5327 4023 2793 7409 2934 5880 58191 2771 389 942 3029 4190 3304 2169 5641 1535 8309 6892 972 4313 1536 3985 1520 2534 7430 3689 3683 3672 1281 3674 7408 3690 5156 1950 330 713 3945 2173 5579 5136 5300 PMC6082850__F8 Antidepressant and anxiolytic mechanism of acupuncture in a PTSD rat model 6853 2475 1977 PMC6082928__F3 LMP1 in the carcinogenesis of nasopharyngeal carcinomas 3550 3718 6774 1956 472 PMC6085667__F5 Compound–target network 1133 6257 2891 1131 125 5321 2147 847 154 126 7422 2475 3091 1017 5770 1544 80312 2155 6714 4129 1956 4282 124 6256 4846 3458 148 240 231 5327 7412 2194 381 487 1545 387 4843 3553 6868 2950 153 4128 596 1111 3569 5294 5781 4314 5468 4353 10062 6307 4953 2697 1277 2159 983 6647 56474 3082 51284 801 4312 4023 2152 2944 5743 3356 1128 1129 7157 3439 1281 1728 998 3558 4313 4306 2946 5970 5733 7498 5594 2932 147 1026 1437 31 1576 5328 1509 1950 207 43 5898 8833 1432 6347 8972 5139 958 3725 3683 79586 5292 51384 1029 6401 3320 3791 1499 7056 5168 6352 7124 890 412 4535 6416 1548 5467 PMC6085667__F6 Targets of signaling pathways 3791 3725 4023 154 4846 153 6257 5321 2475 148 801 890 7157 5292 1111 1017 7422 596 31 7124 3320 2932 1956 5328 5743 4843 3569 4312 51284 3458 3439 6347 2194 3553 6401 5970 1026 7412 6714 5733 1277 5781 207 1950 3082 1281 10062 3558 387 958 1029 4314 5294 157313 1133 3091 983 5898 PMC6086625__F5 Kinases associated with the CX3CL1/CX3CR1 axis 2185 6714 1956 3690 PMC6090926__F1 Molecular interactions between LRRK2, aSyn and p38 MAPK in the regulation of apoptosis and autophagy 998 5879 120892 2475 581 PMC6100747__F1 Ischemic stroke initiates cell death mechanisms in brain cells following an acute depletion of blood flow, resulting in the formation of an infarct core 7097 3553 637 PMC6100747__F3 Notch signaling pathway 28514 54567 10683 182 3714 1950 64782 102 3091 5300 100188776 4609 PMC6100747__F5 Following stroke, the stability of NICD is increased by its interaction with Pin1, and the NICD-Pin1 complex then translocates to the nucleus 64782 7097 5300 3091 7428 PMC6104113__F7 Simplified schematic showing the potential strategy for muscle‐derived miR‐23a/27a to attenuate muscle atrophy and renal fibrosis 3479 5728 4087 PMC6110865__F6 KLHDC7B and the Interferon signaling pathway 3458 5915 6772 6773 8554 581 3437 3430 3665 3659 6890 10379 3434 PMC6111036__F11 D5R mutation induces dilated cardiomyopathy that is related to oxidative stress 581 9817 5350 51199 PMC6113216__F7 RGMa regulation of TGFB1/Smad2/3 signaling in astrocytes 7040 56963 4087 4088 4089 2670 PMC6120446__F6 Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood 1610 4351 6722 367 7124 355 1616 4208 929 23118 51701 4969 1401 4352 2316 PMC6120446__F7 Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood 613 930 1191 5728 572 4199 7975 6850 4610 4602 PMC6121355__F2 Multiple potential neuroprotective mechanisms in Shh signaling pathway 6469 6608 627 4803 581 3553 PMC6121636__F1 HO-1 dependent pathway activated in neurons and in the different glial cells 2668 627 571 PMC6121884__F1 Mammalian target of rapamycin (mTOR) pathway 3667 5728 7249 7248 2475 8408 9776 PMC6125320__F7 The molecular mechanisms underlying the role of mTOR/p70S6K/HIF-1A signaling pathway in the regulation of TLR4 inflammatory signaling and TH17 cells in liver IRI 7099 467 7189 PMC6126011__F2 Leptin intracellular signaling pathway 3667 6774 5163 2885 7249 7248 9021 5443 PMC6127641__F1 Possible cellular mechanisms attributed to oxidative stress in Parkinson’s disease (PD) and possible effects of natural antioxidants on specific pathway 120892 65018 545 847 6098 PMC6128733__F2 Neurotrophin Trafficking via Trk Receptors 4803 5874 115703 547 PMC6130072__F2 Transcription factor interactions in endothelial cell functions 7249 7248 6009 2116 2303 2308 100188776 6010 PMC6136178__F8 DACT2 and the Beta-catenin/Cdc25c pathway 168002 1499 51176 995 891 PMC6139289__F3 A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780 6654 4893 468 5566 1956 PMC6143874__F2 Binding of growth factors and hormones to their respective receptors or ligands serves a pivotal role in Beta-cell proliferation 7040 7054 3479 4092 200186 1017 2146 2308 339122 3651 PMC6143874__F3 JAK-STAT signaling in tandem with multiple cytokines and hormones participates in the regulation of Beta-cells 2056 5617 2305 894 595 896 1019 PMC6144915__F2 Pathway-pathway crosstalk via GADD45B 4088 4089 4616 5609 5111 1021 1019 PMC6147171__F1 A) A simplified schematic of the Wnt signaling pathway 4040 4041 324 3630 PMC6147171__F3 Mechanisms contributing to the repression of hepatic gluconeogenesis by Wnt signaling activation 6934 200186 5105 PMC6147765__F3 Different modalities of cell death 836 999 6010 8772 355 10533 83734 9140 9474 64422 3606 2879 PMC6154995__F7 Heme-dependent feedback inhibition of ALAS in the heme biosynthetic pathway 7390 7389 2235 130749 PMC6156463__F5 Distinct metabolic pathways in cancer cells and their connection to epigenetic modifications 3099 3098 10135 2475 3417 4507 10419 5105 3939 4190 5132 47 4191 55902 3418 2744 2153 6510 PMC6156496__F4 Core interactions between the mTOR pathway and Alzheimer's disease 2308 6009 468 7942 10797 3091 1977 PMC6156597__F13 Mapping of the DE genes exclusive to the oval morphotype on KEGG metabolic pathways– 23574 8314 258010 100187907 4508 22926 468 6400 100653365 5371 326 581 338 92737 6402 107966124 5966 5979 100379198 PMC6157710__F1 Directing the use of DDR kinase inhibitors in cancer treatment 5424 8289 29072 2067 6608 11073 1025 7403 5884 2475 84126 472 545 1019 983 7465 993 995 1021 1017 595 PMC6158335__F2 Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection 1636 3240 1080 PMC6158479__F2 Protective function of the calcium-sensing receptor against inflammation and carcinogenesis in the colon 846 999 1499 6657 79923 4920 7474 PMC6162711__F2 NFKB1 p105/p50 regulation of gene expression in cancer 3065 7422 6280 4616 2919 2920 3603 7185 1956 3627 PMC6165719__F1 Signaling pathways underlying synaptic plasticity in striatal direct pathway spiny projection neuron 5091 5153 1020 PMC6167374__F4 Prominent changes upon ageing in the central carbon metabolism 6888 5834 5836 230 2820 178 5091 3032 7167 1384 5236 3098 5213 8540 2821 788 47 6576 6010 2597 2026 5230 26227 5223 2023 2020 1892 2271 5160 5214 1737 1738 5162 8050 48 1431 50 3420 3421 4191 4967 1743 9242 6389 6390 8803 8801 3033 1374 2806 3419 8802 PMC6168472__F7 Proposed mechanistic model of KMT2D in prostate cancer 3976 5008 3977 5170 8085 9314 PMC6172014__F1 Fibroblast growth factor receptor (FGFR) structure, FGFR signaling, and specificity of the FGF–FGFR interaction 10818 2885 3553 PMC6175949__F8 Proposed positive feedback mechanism for Th17 cell-secreted IL-17A and NLRP3 inflammasome activity in a circuit 114548 22861 3553 3603 PMC6176484__F2 Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer 1021 1019 4194 4193 4613 5163 PMC6186418__F2 YAP/TAZ upstream signals and downstream responses 4485 9113 26524 4040 4041 324 7074 6010 PMC6197473__F2 Snapshot of protein-protein interactions involving p85A (the “p85A network”).The binding to PTEN and to BRD7-XBP1 has a negative effect on PI3K activity (red color), the first by stabilizing PTEN, the second via p85A depletion (, , –) 5728 29117 7494 998 PMC6200785__F8 Indian hedgehog homolog signaling pathway 4171 4175 9314 5241 64321 2099 3549 5727 8643 9464 54361 650 PMC6202827__F7 IL-1B signaling pathway in CXCR3-mediated MSC transendothelial migration 3553 9242 4283 2833 PMC6203147__F10 Activation of EGFR/PI3K/Akt signaling pathway 26018 100422909 581 PMC6206039__F7 Scheme summarizing the inhibition of cisplatin-induced nephrotoxicity by maltol via the down-regulation of AMPK through PI3K/Akt pathway 7124 581 836 842 2475 8772 8717 7186 PMC6206573__F8 Ban-Xia-Xie-Xin-Tang on TNF signaling pathway 8772 836 83737 7975 5966 7185 3976 8717 3726 51073 64127 7186 7187 9049 843 4099 1891 1810 PMC6207586__F6 Mechanism of action of microtitre plate based complement activation assays 729 730 735 PMC6209826__F10 We observed that chlorogenic acid showed binding affinity to interact with ctDNA, VEGF and VEGF receptors 7424 3791 2247 2353 1956 7040 4312 5290 3725 7422 7157 4314 4313 2475 2309 2308 2006 4193 7078 7076 7079 3606 4323 7077 7045 5293 4318 5291 PMC6215314__F6 Illustration of heterogeneous cancer death induced by dihydroartemisinin plus epirubicin liposomes through autophagy, apoptosis and necrosis 581 22863 7405 PMC6217807__F6 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma 1610 1956 126669 2475 5728 4193 29789 1021 1019 PMC6218675__F1 Nuclear envelope proteins and their potential roles in EDMD physiopathology 2885 4087 4088 387 4089 3799 3930 6722 PMC6220384__F1 HMBG1 and inflammatory and immune processes 3146 6387 7099 7852 6774 PMC6231613__F3 Novel protein signatures suggest progression to muscular invasiveness in bladder cancer 253260 7494 7157 1473 5428 1836 182 9493 81539 79767 55571 574414 9415 6522 2000 2475 PMC6232724__F9 Schematic diagram of icariin regulation upon PA-induced insulin resistance 10628 3667 6774 PMC6237163__F6 Result of RNA-seq mainly involves the signaling pathway 5335 695 5578 9846 4067 10000 2534 5609 1437 6850 3937 1432 27040 5594 10451 5894 3265 7124 8517 4790 1147 3606 3551 4792 10454 23118 3569 54106 6885 51284 3592 5604 1326 4615 3576 5606 7189 3654 6352 2353 3663 5599 414062 388372 4094 3565 3566 4772 3567 2625 3596 6778 3586 3561 3458 PMC6237564__F7 Stimulation of autophagy by MAC in lung cancer cells 7249 664 2475 PMC6240607__F4 Schematic depiction of GDNF/RET/GFRA1 signaling in the ureteric bud (UB) tip during kidney development 2118 2119 2668 5979 2674 7481 1848 10252 PMC6245951__F7 Attenuating Effects of 1,2,3,4,6 Penta-O-Galloyl-Beta-D-Glucose on Pro-Inflammatory Responses of LPS/IFNGamma-activated BV-2 Microglial Cells through NFƙB and MAPK Signaling Pathways 126669 2885 1794 7074 3702 998 387 1398 7097 10333 54472 114609 8772 3929 4615 929 23118 7099 51135 3654 7189 PMC6251040__F1 Three modes of programmed cell death 355 3479 2475 581 317 197259 PMC6262497__F3 Notch signaling pathway after treatment with N4-Eru 8650 3280 388585 23385 PMC6262497__F4 JAK-STAT signaling pathway after treatment with N4-Eru 3718 2885 3932 6850 5894 2002 3559 PMC6272897__F5 Putative pathway for the inhibition of inflammatory signaling events by AQCA in in vitro inflammatory responses 7099 4615 3654 6850 6714 1386 PMC6278416__F11 ERK/MAPK signaling pathway in liver metastasis of colorectal cancer 2885 5608 8682 5337 2317 5613 PMC6279938__F1 Impact of i-proteasome subunits on innate immune signaling in myeloid cells 7099 51284 54106 7098 4615 7189 7187 8195 3661 3665 1236 3553 958 941 942 PMC6281268__F8 Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis 100188864 4049 10090 6761 7124 PMC6281417__F7 Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation 5728 2475 7084 PMC6283278__F1 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing 65018 10059 4780 4899 7019 55669 4976 9927 51024 PMC6283278__F2 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing 51024 4221 4976 2308 2309 2152 23411 9927 4780 4899 7019 7018 65018 54106 115004 29110 55669 PMC6284329__F3 Decorin in cancer, based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (http://www.genome.jp/kegg‐bin/show_pathway?hsa05205) 2475 1975 5163 1956 967 836 27250 7097 7099 7124 7422 7078 4313 4318 PMC6284756__F9 Regulatory effects of miR-1292 on hADSC senescence and osteoblastic differentiation 4041 6104 10023 1499 324 51176 4040 PMC6290060__F3 MAP of “p53 Signaling” pathway in (A) HSAEC and (B) A549 cells treated with 1 μM PG over 24 h 7490 3725 133746 23650 5728 57103 5111 355 581 11073 7054 4193 64065 94005 55214 1017 8554 23041 9997 PMC6292430__F2 Does Axl have potential as a therapeutic target in pancreatic cancer? 558 2621 1956 6772 PMC6296439__F6 A model for the effect of JCAD CAD risk genotype on the Hippo signaling pathway 6010 4485 9113 57608 26524 PMC6297716__F4 Scheme illustrating the signaling pathways and transcription factors contributing to SND1 promoter activation 6667 27044 7494 22926 PMC6297832__F6 Proposed mechanisms of anthocyanin’s effect on NVU dysfunction after ischemic stroke 572 114548 581 PMC6299067__F2 Lysophosphatidic Acid 's effects on ion channel regulation 4018 7442 6010 PMC6303891__F7 Putative mechanism is demonstrating how the loss of SEMA5A can trigger EMT 9037 999 1499 2932 PMC6305585__F4 APOBECs-mediated RNA editing in cancer development 9 339 4763 200315 7490 PMC6306698__F6 Pharmacological regulation of pluripotency circuitry establishment during cellular reprogramming via the FEN-stimulated PPARA regulatory pathway 2494 5465 79923 6256 PMC6307518__F1 HMGB1-RAGE/TLR-TNFA signaling pathway 3146 7099 7097 23411 PMC6307844__F1 Pathways participate in tumourigenesis of CCA 324 2932 1499 PMC6308626__F2 General mechanism of the extracellular signal-regulated kinase (ERK) pathway and key downstream products important in cocaine addiction 1020 2353 3725 PMC6313860__F2 CLV-WUS signaling pathways in model and crop plant meristems 6476 2353 2221 7959 PMC6314136__F6 Dynamic gene expression profiles of CIK cells involved in the cell cycle and the natural killer cell–mediated cytotoxicity pathway 9978 10274 10735 4089 6502 2932 9184 7529 7531 7533 894 896 1017 140805 4999 23595 1871 10926 5000 637 836 355 4087 5111 990 8318 3683 920 PMC6314405__F1 Immunological pathways targeted by the main novel therapies for IBD 8178 7054 8174 PMC6314413__F3 Representative Wzx/Wzy-dependent capsular polysaccharide (CPS) biosynthesis pathway in the group B streptococcal serotype III 51083 60592 84680 PMC6315857__F1 Transforming growth factorB 1 (TGFB1) mediates a signaling pathway in tissue fibrosis 7046 7189 4088 4087 387 545 472 4092 4089 2475 PMC6315862__F2 Overview of the DSB repair mechanisms 3981 9156 5893 PMC6320933__F3 Regulatory network of MBP-1 574031 150365 5281 2064 PMC6321180__F1 Canonical Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) pathway and non-canonical Wnt/Ca2+ and Wnt/planar cell polarity (PCP) pathways [,,,,,] 4920 6259 4041 2932 324 998 387 PMC6321280__F3 Many molecules regulate apoptosis and Hippo-YAP signaling pathway 9641 83737 166824 7022 92359 4485 6271 84962 55294 5371 1958 387 PMC6323238__F1 Regulatory system of ERK1/2 signaling 1956 126669 1848 1849 1852 1844 1846 2353 8844 283455 1847 4609 PMC6323245__F2 PI3K/Akt signaling pathway and glucose metabolism (glycolysis, glucose uptake, nitric oxide glucose synthase, apoptosis and cell survival) 1950 1956 5728 5163 5164 2475 572 PMC6323445__F3 FGFR1/FGF21/BKlotho complex actions in the cardiomyocytes 26291 2260 7352 207 6648 572 PMC6328441__F4 Mechanism of CHOP regulation in ER stress induced apoptosis 22926 7186 83939 85451 468 467 9529 581 637 PMC6328940__EV1 B‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice 51117 79934 57017 10229 93058 51805 27235 51004 84274 PMC6328967__F5 Interaction between COX-2 signaling pathway and HCV core protein 27035 50507 847 PMC6329627__F1 PG biosynthesis, receptors and signalling pathways 4512 5228 5226 6010 PMC6329627__F3 Molecular mechanisms for PGE2‐cytokine crosstalk in facilitation of adaptive Th1 and Th17 cell responses 940 958 200186 3595 6774 3558 149233 PMC6330281__F2 Wnt signaling cascades 50964 1499 324 2932 4040 4041 PMC6330346__F3 Rapamycin inhibits the de-differentiation of vascular smooth muscle cells 3553 2260 2475 10818 PMC6330712__F3 Simplified pathway for the synthesis of the GPI-core (based on Cardoso et al., ) 5283 8818 8813 2821 100379198 PMC6332843__F2 PD-1 signaling in B cells and T cells 613 948 6850 7535 5336 PMC6337367__F1 Kinases in the insulin signaling cascades and its interaction with nutrients in control of FOXO1-mediated physiological function 5728 3667 8660 8473 181 3162 183 PMC6343143__F2 Proposed model of estrogen-induced ROS generation increase in thyrocyte 7173 50507 6741 PMC6345610__F3 Illustration of the role of FUNDC1-related MAMs under physiological conditions 139341 7416 51024 PMC6345611__F1 B-cell receptor (BCR) signaling pathways important to the pathophysiology and treatment options for chronic lymphocytic leukemia (CLL) 613 4067 6850 29760 2885 695 PMC6347560__F1 Ribosomal stress (RS) pathway and its hypothetical role in neurodevelopmental syndromes 27343 11201 4193 4869 7157 PMC6348090__F10 Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma 253461 1017 1021 1019 545 472 94005 2475 5728 4193 PMC6350303__F9 Molecular mechanism of ZNF326-mediated regulation of Wnt signalling 284695 8312 324 51564 6925 847 PMC6351175__F7 Hypothesized regulatory relationships between TGFB, Tgif1, miR‐18a, and NeuroD during photoreceptor differentiation 4087 4088 7050 PMC6352376__F4 Functional analysis of significantly changed proteins (SCPs) 55365 7369 54732 28959 310 4043 10763 6430 5685 6428 1014 633 2495 4036 306 9689 1200 51752 1284 5901 7052 2771 1665 3920 4311 5641 7533 6432 9184 6194 4074 8972 6232 1509 290 309 3916 2638 3315 7431 1808 6281 6559 9093 7171 3685 26090 7277 70 4478 2166 83594 7150 5340 10427 71 462 55666 56886 10627 29927 7155 4627 9695 1603 5625 5756 3263 4648 10398 523 87 60559 479 4637 2243 81 4967 116285 2244 5858 5345 526 7045 4694 4329 139322 481 34 4713 4719 4729 38 374291 4695 4697 4716 8879 4722 4705 4698 10449 126328 4718 4714 54927 1346 2180 80724 4702 4704 157378 5226 91949 8402 1292 1291 2266 57017 PMC6357148__F2 Filovirus replication cycle showing host and viral proteins that either promote (green boxes) or block (red boxes) virion assembly and release 4734 11059 9021 9636 9531 7251 83737 PMC6357186__F6 KRT19 and Wnt/beta-catenin/Notch signaling pathway in colon and breast cancers 3880 847 5879 8650 51176 6932 PMC6358521__F1 Lessons learned from the study of human inborn errors of innate immunity 7100 7096 613 958 4055 7297 3595 3717 114609 9636 3594 149233 4615 3716 3459 3460 51135 6772 10892 81858 84818 5970 5971 6774 1638 PMC6363433__F2 Folate decomposition and damage repair 6470 10588 5860 1719 471 PMC6365085__F9 MicroRNA-223 attenuates LPS-induced inflammation in acute lung injury model via the NLRP3 inflammasome 7099 114548 388 3553 PMC6365103__F1 Copper distribution pathways in a generalized mammalian cell 9973 6647 55240 538 475 540 PMC6368372__F1 Proposed mechanisms of action of glutamatergic modulators and other putative rapid-acting antidepressants 3972 100170220 627 29904 2932 1938 PMC6372590__F5 PAK4 signaling in health and disease: defining the PAK4–CREB axis 4157 324 2932 1499 PMC6375727__F7 eIF2BE Constitutes a Pivotal Node between the Responses to Canonical Stress and Sema3ASema3A induces an initial (5 min) wave of local translation independent of the eIF2 pathway mediated by ERK-1/2 and mTOR 10371 2475 2932 1967 1998 PMC6384086__F11 Cofilin regulating the actin cytoskeleton and initiating PHEV entry 2695 998 5879 PMC6386894__F3 cAMP regulates immune response of astrocytes 7412 3383 3550 718 6347 PMC6395431__F1 Biochemical pathway 5832 4942 4998 435 5009 383 PMC6397079__F7 The effect of miR-15a-5p on MK GPVI signaling 1401 6850 2534 5336 4638 PMC6397804__F2 Poly(I:C)-toll-like receptor 3 signaling pathway and polarization of mesenchymal stem cells 7099 9242 7098 3661 PMC6398012__F6 Proposed mechanism by which type 2 diabetes (T2DM) and aerobic exercise can affect the brain and lead to alterations of hippocampal glucose metabolism with subsequent effects on synaptic plasticity-associated proteins 23411 2475 114548 3603 PMC6398501__F8 An integrated model for ROS mediated clearance of VAP(P58S) aggregates via UPS 6647 7415 2475 PMC6398583__F4 ERK- and JNK-mediated phosphorylation of PKM2 is at the crossroad between proliferation and apoptosis 1950 54625 5300 PMC6401644__F3 PIN1 acts at multiple levels of cooperating cellular pathways 4851 5300 85451 55294 595 PMC6405523__F4 IIP-effectors in FOXJ1 regulatory network and their probable ciliary associations 65057 6498 4609 348 25913 23493 6667 7419 7157 1869 7013 54386 3064 51588 25814 26277 2040 10381 991 54970 7428 83696 22897 6502 27152 1356 10746 1499 324 85302 135138 5129 3320 8945 2289 29922 7316 22954 6500 7415 2932 5970 5702 8473 8517 8100 29110 6310 351 140735 388389 55081 4223 1600 9021 329 11035 56288 88 1742 2302 60412 27031 8772 54413 10210 10492 2316 330 2885 5311 10539 1915 998 145508 117178 50855 6010 84140 585 26121 10458 2033 993 5590 1432 583 PMC6409899__F3 The Fanconi anemia pathway suppresses R-loop-associated genome instability 672 23064 2177 57697 6050 PMC6413549__F4 Biochemical process networks of the differentially expressed proteins generated by MetaCore™ software using a transcription regulation algorithm 10294 7295 10963 3301 5629 51726 3337 5704 5702 4023 5611 335 26986 52 811 5706 290 10971 3315 7529 3336 PMC6413748__F3 Synthesis pathway of cardiolipin from lysophosphatidylcholine and lysophosphatidic acid 3931 95 283871 114971 PMC6415584__F1 Pyruvate and glutamate are 2 major metabolic hubs in GSCs 3099 2744 355 3418 5091 PMC6416106__F2 Glutamine metabolism and macrophage polarization 3417 18 3603 PMC6417013__F1 Main aspects of folate receptor signaling and C1 metabolism discussed during the meeting 4524 6470 6472 10797 6774 PMC6417835__F3 Architecture of the Fanconi anemia (FA) core complex, with FAAPs (Fanconi anemia–associated proteins) indicated by numbers 57697 51455 2188 2189 2175 2176 2187 55120 29089 2178 PMC6421044__F3 Regulatory loop among Kaiso, Wnt11/5a and Suz12 23512 7481 7474 PMC6423135__F5 Pathway scheme with marked involved proteins 10818 2885 126669 572 387 100187761 7189 5879 64782 3725 PMC6425072__F2 Neurotrophic factors and their receptors in dopamine neurons 627 4902 2668 9518 1270 3976 5979 7873 2674 389400 441549 3977 1271 PMC6428091__F1 Cytosolic glucose enters glycolysis and pentose phosphate pathways 8504 2539 2819 4018 5192 355 2717 1896 PMC6429142__F8 Tangeretin-induced apoptotic pathway in BFTC-905 bladder cancer cells 596 637 572 581 PMC6433121__F4 Proteins that Are Rhythmic in the Pentose-Phosphate Pathway Peak in Anti-phase to Those in Glycolysis 7167 2203 2014 2819 2027 PMC6433803__F2 Influence of non-oncogenic viruses on the components of non-canonical NFKB signaling 7186 7187 57506 5971 3383 1616 6363 PMC6434253__F2 Sub-pathways identified using the sub-pathway strategy 2475 4609 10000 374987 4893 2065 3725 2885 1956 7629 100287569 1147 100507321 56252 4067 6464 3845 58491 5331 2783 PMC6437734__F1 VPA inhibits LPS signaling in macrophages 929 4615 51135 5728 7189 23118 257397 8195 4193 PMC6437734__F4 VPA inhibits monocyte to DC cell differentiation 3662 941 942 3383 6778 3566 9308 6774 3565 PMC6437734__F10 VPA impacts the B cell differentiation into plasma cells and in the isotype switch and maturation affinity of immunoglobulins 958 3566 22937 639 57379 969 PMC6437734__F12 VPA promotes the generation of Treg cells 920 2114 4088 50943 PMC6438043__F5 Pathway representing T cell signaling 942 941 3558 915 920 5788 925 613 940 3560 6850 29760 3932 695 3937 7409 2885 5335 10125 489 814 4773 3725 2002 PMC6441712__F7 Effects of SIRT2/cMYC pathway in CCA cells.SIRT2 and cMYC reprogrammed the metabolism of CCA cells by up-regulating downstream p-PHDA1 and PHGDH/PSAT1/PSPH 22933 26227 5160 5723 PMC6443256__F1 DNA sensors and related signaling pathway 115004 51428 4361 170506 1660 9447 57506 29110 3553 3606 3428 3661 3665 54106 4615 PMC6443714__F1 The cytoplasmic destruction complex constitutively targets Beta-catenin for degradation 4041 1499 9242 PMC6447583__F8 Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge 3479 182 388585 PMC6447777__F2 Candidates of miRNA-based therapy against perinatal hypoxic-ischemic brain injury 7099 51135 6722 387 442890 5728 5978 182 5729 2247 9242 PMC6449344__F1 CpgA is pivotal in prevention of 4PE-mediated metabolic gridlock 3250 4668 6120 7086 PMC6450748__F10 Ethanol induces hyperacetylation and hyposuccinylation of mitochondrial proteins involved in diverse metabolic pathways 6648 3418 2876 25824 38 3030 3158 549 10449 2110 2108 2109 55856 95 1376 10901 25874 217 5091 2806 4191 2746 2271 5009 1738 6389 498 506 513 514 509 8803 4695 4709 4719 7385 80221 PMC6453741__F4 Functional role of CLDN1 in signal transduction and EMT in liver disease 9076 4313 6935 PMC6453877__F3 HIF-mediated suppression of ROS 2730 26227 6472 56901 6648 23657 PMC6466717__F2 Biosynthetic pathway of Plasmalogens 95 55711 84188 PMC6468516__F2 Metabolism in tumor cells 2597 2885 1431 PMC6468748__F1 Moonlighting functions of the endothelial protein C receptor (EPCR) 324 5091 5340 PMC6468848__F2 The Notch signaling pathway 100188776 595 6657 1024 PMC6468893__F10 Dual prey-inactivation strategy of the venom of C 375616 5066 1636 PMC6473623__F2 Autophagy Intertwines with Different Diseases 9776 8408 3920 9140 83734 9474 10533 55054 55014 55062 23001 9447 1856 90427 4210 171024 9667 23118 51112 7284 65057 64422 3281 472 PMC6474359__F2 IL-17 family of cytokines in health and disease 84818 572 790 10865 7186 7188 7189 6850 PMC6474664__F3 Identification of unique pathways after treatment with SC-3–141 124801 1730 9055 9833 401541 699 9918 822 259266 6882 11001 324 1063 PMC6478801__F8 SNG mediated action in MM cells 3717 6774 596 581 735 331 718 PMC6480215__F2 Calvarial bone development and suture closure 6696 3381 1277 860 3371 4684 2261 2263 2735 5727 3549 7471 7480 5744 1749 PMC6480367__F1 Rapamycin (mTOR) signaling pathway 5728 2885 5163 7249 7248 6009 64798 9675 PMC6482176__F1 The Insulin Signalling Pathway and insulin resistance 3667 5728 10890 PMC6484783__F2 Histone chaperoning pathway: from ribosome to nucleosome 146059 79711 8520 3837 4678 11011 9874 9869 55705 PMC6485480__F1 Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers 6482 10610 55808 56913 9245 51301 2650 2525 10690 2529 2528 2527 9435 10164 2651 6487 2683 2526 10402 84002 9334 7357 9394 9653 3340 9348 64579 8509 9957 2132 2131 2134 64132 64131 27087 126792 11285 PMC6487163__F1 Process and regulatory mechanism of autophagy 2475 8408 9140 9474 PMC6488374__F3 Molecular mechanisms that regulate quiescence and activation of McSCs niche in telogen and anagen, respectively 28514 27122 1601 4041 4040 7939 4781 1308 4087 3280 4286 1906 1907 1499 PMC6488418__F4 Figure 2.CD36 redox signaling in vascular smooth muscle cells, microvascular endothelial cells, and monocytes/macrophages 948 2534 9817 7001 6850 PMC6491684__F8 Schematic representation that hypothesizes the effects of ethanol (A), THC and/or OEA (B) on neurotrophic signaling pathway via AKT and ERK1/2, and its neurogenic response in the hippocampus 627 4288 4908 1641 836 PMC6498606__F7 Model of PAPP-A-driven PABC 55323 3488 4921 PMC6498619__F3 Evolutionary conservation of the IIS pathway 3479 3630 207 2308 2309 4303 2152 7249 7248 6009 PMC6499508__F6 Graphical summary 948 3458 6721 3156 255738 7038 3949 5467 666 7351 338 1071 5091 3931 875 3579 2194 729230 8740 3606 6720 7099 19 7124 9619 2625 PMC6502998__F2 Marè et al 1312 790 1431 2271 PMC6513092__F7 PIN1and PTOV1 pathway interactions 53635 10399 5300 891 581 1499 5599 PMC6513850__F8 Diagrammatic model summarising the proposed bimodal Wnt signalling regulation by DYRK1A, as reported in Figs – 1859 324 847 PMC6514153__F3 Reelin signaling pathway in Golgi Dynamics and morphology 6714 1600 23122 5879 998 2932 3984 7436 PMC6515079__F9 Network analysis of proteome datasets in M1 polarized (vs 7532 55502 60 1655 3858 1269 4437 1356 966 3921 226 23499 8570 3313 3312 71 3183 5052 PMC6515458__F3 Protein–protein interaction (PPI) network in muscle wasting in cancer cachexia 9370 3240 3326 6387 9146 664 2308 7075 23710 4626 5105 2660 857 6774 57104 113 2908 80333 3290 7846 9021 7277 3726 114907 4314 816 2266 70 4208 5058 10726 84676 7352 7249 716 10468 10218 PMC6519821__F7 Proposed molecular mechanism of the anti-esophageal cancer activity of Rk3 2475 581 572 9474 842 836 595 1019 PMC6520938__F1 Canonical Wnt signaling pathway 324 595 8549 847 PMC6521028__F8 Mechanism of PDCoV N protein interfered with the type I IFN response 3717 57506 5478 6773 7187 3665 3661 3716 PMC6521842__F9 A putative signaling pathway of ERK5/ankrd1 for promoting catecholamine biosynthesis 4803 27063 7054 PMC6522926__F5 Schematic representation of the E2/ESR1/CD36/PPARA pathway in skeletal muscle cells 948 2194 7038 PMC6523301__F1 Main cellular protein clearance mechanisms, the ubiquitin–proteasome system (UPS), and the autophagy pathway 6184 6185 22863 10533 9776 83734 64422 9140 9474 PMC6523687__F1 Epidermal growth factor receptor (EGFR)/EGFR variant III (EGFRvIII)-dependent biological signaling pathways 1956 5728 2475 PMC6525811__F2 miRNAs that indirectly impact Alpha-syn without binding to its 3′-UTR 407009 407037 406950 7942 9776 387 26281 PMC6526899__F4 Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway 788 1891 1629 2108 3421 28957 4329 5096 28977 6182 218 5095 2271 55037 3700 3827 3336 51263 65005 29789 3417 64960 4939 79132 4600 64108 1376 55052 PMC6527596__F1 The regulatory mechanism of miRNAs in TLR signaling 7099 10333 81793 51311 54106 51284 3654 3656 7187 3553 7124 4615 4790 7098 8651 7189 11213 23118 9306 84231 8773 7096 7097 PMC6530392__F1 Sublytic C5b-9 promotes tumor growth and survival by activating several signaling pathways 3716 207 6774 572 2002 2308 5163 581 51083 PMC6531857__F4 Regulated necrosis: disease relevance and therapeutic opportunities 2744 875 7296 1491 2937 2936 4015 2879 PMC6533683__F1 mTOR signaling pathway regulated autophagy and EMT 2932 1499 2475 5879 10533 9474 3611 4087 4088 PMC6533683__F8 TGFB signaling pathway regulated autophagy and EMT 9474 10533 6774 4087 4088 1499 5141 PMC6536572__F3 Nrf2/ARE pathway during basal and stressed conditions 9978 8452 2932 1728 PMC6537107__F3 Changes in PUFA metabolomes are conserved across pharmacological and physiological models of skeletal muscle injury 3240 5228 4049 7054 4050 5226 PMC6539695__F4 Pathways of EGF mediated protein synthesis and PDCD4 degradation 2475 27250 1977 PMC6539695__F7 EGF and TPA mediated pathway to phosphorylate serines in the SCFBTRCP recognition site of PDCD4-protein in Huh7 hepatoma cells 1950 2475 27250 PMC6539782__F1 Carbohydrate and protein metabolisms 10230 5163 23411 283120 100302692 1958 5208 60674 23657 5820 PMC6539971__F1 Microtubule-associated protein 1 light chain 3 (LC3)-P62 autophagy signaling pathway 9474 9140 10533 64422 PMC6540463__F4 Hippo signaling pathway which was achieved by DAVID pathway analysis 10207 154796 64398 374 174 3398 4609 324 PMC6541953__F2 Anti-inflammatory and antioxidant mechanisms of neuroprotection and neuronal function by ursolic acid 4025 847 1728 2475 PMC6544937__F5 miR-15/107 family targeted genes in cell cycle KEGG pathway calculated by miRPath v3.0 web-server 1387 5885 5591 5111 1017 1022 10926 5966 PMC6548002__F5 Signaling pathway based on the literatures we reviewed 146433 5764 2066 28964 6935 4897 5803 1499 92737 5728 6714 595 4609 PMC6548990__F4 Cytotoxic TLR-TNF signaling network 7098 7099 4615 8737 8772 841 7187 23118 1540 7186 253868 11035 331 197259 5970 3553 7124 PMC6549747__F1 Signaling pathways implicated in different categories of breast cancer 2885 2260 2475 3480 1956 3815 4040 4041 1499 324 PMC6558179__F5 Underlying mechanism of SSa on T cell-mediated immune surveillance in breast cancer 920 6775 7297 PMC6559821__F3 Main signaling involved in non-canonical pathways regulating HIF-1/2 2475 5728 6194 7428 PMC6561919__F7 ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation 545 5111 5980 PMC6562634__F2 The Hippo pathway drives fibrosis across the organs 4771 60485 4485 9113 26524 PMC6562634__F3 Schematic model of regulation of the Hippo pathway by numerous signaling pathways in cancer 3611 4771 5058 4485 9113 26524 4038 4593 PMC6562751__F2 Signaling Pathways and Cellular Processes Regulated by Keratins, Vimentin, and Nestin 2260 8717 6714 7249 7248 1956 2475 3190 4087 4088 6774 326 2833 114548 6667 6670 1020 2932 10399 5879 1499 3265 558 PMC6562915__F2 Illustration of the main signaling pathways activated upon Ang2 binding to endothelial cells 7075 2534 2242 5879 2308 PMC6562953__F1 RKIP protein as a signaling modulator in lung cancer 4771 6774 6469 PMC6565612__F1 The roles of the cAMP-PKA and cGMP-PKG pathway in DRG neuron hyperexcitability after peripheral injury or injury- related stress including chronic compression of DRG (CCD) and acute dissociation of DRG (ADD) 2638 63895 8989 7442 PMC6567810__F7 Construction of a regulatory network for integrated miRNA-target genes 6774 10891 5991 8648 23060 80312 64764 7003 91404 7182 4306 6667 7586 7046 PMC6579706__F1 Unfolded protein response (UPR) 83939 7494 22926 PMC6581914__F10 Scheme and working model 5209 5091 3375 PMC6585021__F4 The molecular mechanism of OM antifibrogenic effects.OM could attenuate HSCs activation induced by TGFB1 in vitro by down-regulating the expression of miR-195 and up-regulating Smad7 4087 4088 4092 4089 PMC6587955__F1 BMPR signaling 90 659 92 93 4092 4091 6010 3397 3399 PMC6587965__F1 Cellular Signaling Pathways Modulated by Low-intensity Extracorporeal Shock Wave Therapy 627 6714 7249 847 2475 PMC6591367__F7 Possible underlying mechanism of PAR4 signaling 940 5728 2308 2475 50943 PMC6595474__F8 Summary of mechanisms by which exosomes from cyclic stretch-exposed PDL cells negatively regulate IL-1B production in macrophages 7099 114548 3553 PMC6599650__F1 Schematic illustration of the formation of pH- and redox-responsive, methotrexate-loaded, APP-derived micelles via self-assembly in aqueous solution 351 4318 4313 PMC6600376__F1 ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis 7040 2247 3458 7039 4318 4321 7852 3082 PMC6600376__F2 Mitogen-activated protein kinase (MAPK) cascades in activated, myofibroblast-like hepatic stellate cells (HSC/MFs) 1950 998 6010 3725 5076 790 8516 PMC6603400__F1 Diagram of ellagic acid target proteins from the DrugBank database 29760 759 6713 6850 5063 761 5579 762 5578 5566 253260 1457 765 23632 766 771 768 57521 5350 7204 PMC6608593__F4 PANTHER Pathway: an ontology-based pathway database coupled with data analysis tools 157 156 2870 5894 PMC6610456__F1 TRAFs in IL-17 signaling pathway 1956 84818 7187 9618 7186 7188 257397 7189 10865 29761 10682 84630 PMC6610925__F1 Hexosamine biosynthetic pathway 5238 8473 10724 PMC6610925__F4 HBP regulates multiple proteins in cancer cells via OGT 999 8473 2271 2475 1386 3014 2309 PMC6612501__F1 TLR4-mediated inflammatory signaling pathway in the rumen epithelium 3458 7099 4615 6772 3661 PMC6613992__F1 Endogenous oxalate synthesis pathway in hepatocytes 183 1610 2739 PMC6614129__F3 Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders 7186 572 2932 3065 3066 PMC6616015__F2 Gene-gene interaction networks 5987 10951 54793 79092 6606 2590 51378 23504 57758 9435 253152 9889 55753 93663 55698 57211 7851 1017 5966 441478 5558 131377 PMC6618143__F3 Macrophage metabolic pathways 5226 5209 5207 355 383 47 730249 3603 56670 PMC6624447__F6 Canonical pathways generated in Ingenuity Pathway Analysis of Oncostatin M signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi 5008 9180 2813 2885 4314 4322 5328 4312 4502 1116 2034 7078 PMC6625911__F1 CaMKK2 and advanced glycation endproducts (AGEs) within the bone microenvironment 10645 6662 7099 4772 1050 1051 860 650 249 1513 54 PMC6626338__F7 LUCAT1 and Wnt/beta-catenin signaling in breast cancer 100847020 324 1499 6934 100505994 4040 4041 PMC6627123__F5 Involvement of FGFR4-related signaling pathways 2549 10818 1398 2885 6461 2475 1581 6714 5728 PMC6627624__F5 Scheme to summarize the current understanding of triterpenoid biosynthesis in metazoans 4598 3422 8213 PMC6627635__F3 Predicted/established targets of selective flavonoids in platelets: Flavonoids modulate platelet activation through multiple mechanisms 27040 2534 6850 4512 PMC6627782__F2 Network of the sperm proteins differentially associated with male age 3306 5600 7203 1432 6300 836 306 4628 3308 5603 4627 5599 10574 7157 10000 207 3315 2194 2923 308 10971 2475 208 1191 2932 572 6277 6194 6198 84335 1509 51700 4957 23170 284382 51181 160065 5214 PMC6628002__F2 Schematic representation of physiological and pathological aspects (major sources of oxidative stress) in Alzheimer’s disease (AD) and their corresponding antioxidant defense approach by anthocyanin in cholinergic neurons 2670 351 581 836 PMC6631235__F5 SAM on signal transduction pathways 2305 1843 6502 652995 328 PMC6635885__F2 Activation modes of the NLRP3 inflammasome and the regulatory mechanism of CVDs 6262 10628 846 3553 114548 7099 3606 PMC6645245__F11 Schematic diagram representing possible antifungal mechanism (a–e) of CIN and EUG in C 2078 3422 443 1038 PMC6658873__F1 Synergistic effect of three combined strategies by targeting complement/C3aR /C5aR1/IL-10 pathway and other treatment modalities 728 3002 3902 PMC6660170__F1 Nanoparticle-mediated autophagy 2475 9474 9140 10533 4553 PMC6660834__F1 Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease 1499 324 387 51701 4040 4041 6425 PMC6661007__F2 Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases 84876 6786 3091 673 595 7422 PMC6662509__F3 PPAR signaling pathway and DEGs.Abbreviation: DEGs, differentially expressed genes 335 5360 4199 2168 2170 4023 7350 7316 1582 PMC6668488__F7 A proposed schematic representation of Mn-dependent adaptive and toxic response pathways 102 79133 10282 26286 51606 2171 PMC6675602__F7 Pterostilbene (PTS) prevented ROS formation and reversed palmitic acid (PA) mediated increase in hepatic glucose production by reducing expression of genes coding for gluconeogenic enzymes and their transcription factors 5465 5091 847 PMC6677558__F1 Model of the regulation of light-mediated AS 64326 878 3250 PMC6678131__F6 Role of LOXL3 in tumor 84695 5310 3065 3066 999 595 675 5888 4436 4926 8243 PMC6678403__F1 Regulation of sprouting angiogenesis 54567 3280 23462 3423 PMC6678403__F3 Negative role of AMPK in angiogenesis 4086 4090 2475 4089 3280 3423 PMC6678762__F6 Schematic diagram illustrating the proposed SIRT1 signaling pathway involved in PGC1A/mitochondrial biogenesis that exerted an endogenous protective mechanism in the hippocampal neuronal tissue following experimental status epilepticus 23411 7019 4899 PMC6682621__F2 Polyamine metabolic pathway with differential expression genes and reporter metabolites highlighted 4953 54498 6723 6303 6611 PMC6685059__F2 Translational challenges with systemic and local cell delivery 7035 9242 7018 718 1431 928 55686 4179 PMC6687752__F7 CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3 4280 2919 3579 10284 6774 3265 PMC6687767__F1 Natriuretic peptide signaling in adipose tissue 594857 2638 1386 7350 PMC6689183__F8 Dropwort extract exerts broad anticancer effects on MPM cells affecting cell proliferation, viability, migration, metabolism and in vivo tumor growth of MPM cell lines 81788 9891 1499 2475 4176 999 27063 7003 8463 7004 7005 PMC6691238__F1 Cell apoptosis under ER stress 83939 7186 468 596 PMC6694711__F2 Renin-angiotensin system and its bypass loops and converging signaling pathways can be targeted at different points 1499 4513 1636 PMC6695670__F2 Toll-like receptor (TLR) signaling 7100 7097 7099 7096 4615 114609 81793 4118 10333 29110 51135 3656 3661 7189 7098 51284 54106 51311 PMC6695959__F1 DNAM-1 signaling pathway leading to natural killer (NK) cell activation 5819 5817 3383 201633 10225 2534 7409 PMC6696099__F1 Proposed targeting approaches involving ACSL isoenzymes in cancer 2181 2180 95 2182 PMC6697957__F1 Wnt signaling: a promising target for osteoarthritis therapy 2487 324 1499 4314 176 1280 55553 6662 860 50964 4041 PMC6697957__F5 Wnt signaling: a promising target for osteoarthritis therapy 27123 650 4090 4086 4087 4088 324 1278 1499 4040 4041 PMC6700246__F1 Sphingolipid metabolic pathway 95 79603 253782 29956 91012 10715 204219 5091 1674 2581 PMC6701341__F5 Circadian clock pathway mapped with relative expression levels (T1 vs 5617 9118 3492 PMC6701435__F5 KEGG pathway analysis for HepG2 cells depicting the upregulated genes in the TNF signaling pathway after the treatment with TIT3; the altered genes are marked 7124 8772 83737 355 3976 8717 4314 4323 3383 6401 197259 8195 248 4703 6402 PMC6703955__F4 Proteostatic regulation of Ci/Gli proteinsAll Ci/Gli proteins, except mammalian Gli1, have an N-terminal repressor (R), a central zinc-figure (ZnF) and a C-terminal activator (A) domain 51684 8405 7874 PMC6710350__F4 Microglial inflammatory responses by IFNB signaling 7297 3458 6772 10379 6773 8651 6774 2475 9021 4513 3454 3455 PMC6711852__F2 Physiological and pathological hypertrophy 156 406936 5728 581 2139 2309 9759 2475 2626 163732 407004 PMC6712069__F1 An overview of Wnt signaling pathway 6259 1499 8313 324 6010 3725 84133 54894 50964 4041 PMC6712175__F10 Schematic depicting the role of the C/EBP-Beta-lcn2 signaling pathway in MA-induced microglial apoptosis 1051 596 581 3934 PMC6717205__F1 Schematic overview of glycolysis and mitochondrial respiration 5209 2147 3939 3945 PMC6719876__F4 Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences 10923 894 5532 5332 406990 5529 5516 23291 8061 8322 8323 51701 2033 5515 1460 5578 8945 6932 5566 817 7855 PMC6721308__F2 Distribution of the genes significantly modulated in the Alzheimer’s disease pathway 317 5664 23621 57142 351 6868 PMC6721552__F3 Simplified overview of the MAPK and PI3K pathway 4763 5728 7249 7248 2475 PMC6721579__F4 Role of heat shock protein 27 (HSP27) in different cellular apoptotic processes 8772 1616 637 581 PMC6721659__F3 Signaling pathways downstream urokinase-type plasminogen activator (uPA) receptor (uPAR) and its co-receptors 5340 7448 6714 5879 6774 367 PMC6722770__F3a Prebiotics: Mechanisms and Preventive Effects in Allergy 6566 2475 6774 6347 3553 PMC6727512__F3 Biosynthesis of AhR ligands from tryptophan metabolism 1571 717 23475 PMC6731062__F3 Proteins in the glycolysis, tricarboxylic acid, and oxidative phosphorylation pathways examined by the Ingenuity Pathway Analysis software 1311 6389 6392 6390 7054 100 PMC6739326__F8 Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKA signaling pathway 26291 2260 10645 847 PMC6743006__F3 Exposure to high fat diets over time, enriched in saturated fatty acids, would promote the glial activation and an increased mitochondrial oxidative stress 351 3667 8660 5465 2002 PMC6746018__F1 PI3K/Ras signaling pathway 4763 2885 6654 867 673 5163 2475 PMC6759660__F2 Different ncRNAs regulate PDCD4 in mutiple ways 999 1499 406973 27250 11184 1021 1019 406990 693122 55384 2146 7503 401237 79940 100124700 PMC6761220__F3 Strategies for immunomodulation to mitigate periprosthetic osteolysis induced by wear particles 3553 383 9332 4615 PMC6764628__F5 Relationships of the top differentially expressed genes within the top GSEA gene sets 3164 4170 3315 1959 7832 1843 3162 3569 4616 2669 467 5743 6236 133 4071 PMC6768965__F1 Manipulation of the interferon signaling pathway in myeloid cells 11052 25939 11277 57506 115004 29110 7187 51428 3659 3661 PMC6769012__F6 BK ablation attenuates osteoblast bone formation via integrin pathway 6714 5894 860 PMC6769473__F3 Genetic network and functions of PSGs (positively selected genes) related with the KEGG pathway of the PPAR signaling pathway, fat digestion and absorption, vitamin digestion and absorption 5948 123 345 10555 2806 80168 338 6319 151056 9227 10999 4547 2181 5105 30 PMC6770393__F2 Key metabolic remodeling and potential therapeutic targets in glioblastoma (GBM) 3099 5214 1956 2475 5728 7157 3939 3945 55902 4609 586 2746 2744 26136 PMC6770497__F8 Key metabolic pathway and regulatory network in mutant ptsd1 275 9615 1312 790 PMC6770608__F10 Diallyl trisulfide (DATS) protected the brain tissue against the damage induced by ischemia/reperfusion (IR) 9978 9817 6647 6648 PMC6771474__F2 Complement system and crosstalk with other innate immune effector systems in liver IRI, regeneration, and transplantation 718 929 3553 PMC6773825__F2 Main strategies of immunomodulation 2475 1236 939 PMC6775191__F8 Network visualization analysis of “potential lipid markers-lipoproteins-TLR4/MyD88 signaling pathways” for anti-inflammatory effects of HLJDD 64781 64600 338 116519 8398 3991 5321 8877 8399 6609 4615 10400 166929 948 259230 5037 50487 5322 3553 5319 5320 348 84647 94005 100137049 55512 27087 3820 6610 PMC6778377__F6 Schematic illustrating how Nrf-2 activation regulates phenotypic modulation 9817 2729 6647 PMC6779289__F2 PPI network generated for the proteins encoded by the eight statistical driver genes 100507436 22914 5664 3990 3937 4855 6850 5336 54567 1956 3516 338 7006 100124696 4067 29760 3702 3684 9611 405 10499 9612 1604 8648 5469 1675 2168 4179 629 10878 3426 5810 545 3075 6117 10111 641 675 5889 51426 7516 80198 5890 5429 7517 695 3055 8204 PMC6779808__F6 Network analysis from RNA seq 4861 546 3304 23318 2302 84224 4778 5893 5900 8793 7625 64789 51182 7343 10181 PMC6781638__F4 Pathway analysis shows the identified proteins and their respective interactions 85358 5999 54539 4725 4719 2913 84062 9892 4720 26058 4900 8400 348 4731 10274 9745 1806 63944 6854 65078 1815 27185 51079 7317 29801 348980 5533 27089 83857 4712 4696 4722 7332 56924 5567 55967 4717 317 65018 2861 4855 4665 1813 5587 207 1349 4700 2774 627 6570 4706 9627 4697 27429 5566 374291 111 836 5740 118424 4726 341947 7417 51465 2770 152330 8379 56901 4708 4718 29796 7327 4709 4705 6622 4713 1340 4695 1345 120892 4704 6389 1312 2242 135 10975 291 7318 11315 1812 4716 7386 4723 23314 7388 6391 3356 23780 7124 4701 9246 4710 7314 6472 9628 1610 54205 4694 7345 842 4715 4728 80832 7381 5568 4729 2107 26122 125965 7384 6571 6392 7416 126328 4707 4724 2771 10105 57502 4775 1182 6505 4714 2773 8452 351 1537 1350 7326 473 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Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response 2932 11073 545 PMC6828590__F11 Regulatory mechanism of the PI3K-AKT signal pathway in different groups 2475 1977 7248 7249 51083 2885 672 7097 7099 5879 6850 613 930 55872 5163 595 11140 5728 572 842 6256 4193 1975 3667 4609 5934 2695 367 PMC6828590__F12 Regulatory mechanism of the MAPK signal pathway in different groups 4803 1950 1956 2002 6717 4342 4763 2316 1386 4485 7124 7186 4149 4208 355 1616 23118 51295 929 7189 627 5091 6722 100188011 3727 5058 3925 4351 5062 51701 8195 PMC6828590__F13 Regulatory mechanism of the VEGF signal pathway in different groups 4513 998 6714 8544 842 572 PMC6829074__F1 microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways 8717 8772 7186 637 2308 2309 PMC6831867__F1 Reactive oxygen species (ROS) metabolism 27035 50508 79400 53905 50506 6647 6649 6648 847 50507 PMC6831867__F2 Metabolic interplay between various ROS generators 6649 27035 6647 50507 6648 PMC6834859__F1 Effect of GPCRs on RTK transactivation 1956 6714 5163 2475 PMC6834863__F2 The different apelinergic signaling pathways 59272 187 23410 2152 3791 7422 2167 PMC6838739__F1 Signaling pathways in osteoclast (OC) differentiation, survival and death 7189 8717 3725 8772 5741 2475 PMC6843432__F1 BMP signaling pathways 7189 2475 5970 PMC6848778__F9 KEGG analysis of carbonylated lysosomal proteins in human end-stage PSC 3423 3416 7008 5447 PMC6850367__F2 PPARy‐mediated effects in the liver 355 7038 948 PMC6850886__F12 How PPM1H counteracts LRRK2 signaling pathway by dephosphorylating Rab proteins 51699 8934 55737 120892 10890 11021 339122 57460 PMC6850916__F7 Inhibition of leucocyte migration was included in early moderate exercise‐mediated improvement of inflammation 79148 5030 1525 3274 100187907 114609 4638 7057 2247 9966 6440 7421 5478 3105 11025 240 5023 49 4609 PMC6853184__F5 Pathway enrichment analysis of primary human lung cell secretory proteins with decreased abundance in response to PC 4312 4318 4321 1991 4811 4313 4314 4316 4327 999 11174 9507 11096 4323 4324 960 102 8751 1520 5340 1075 2012 5650 PMC6854009__F4 Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Infected Subjects (–) 1610 613 1540 10913 7124 1270 1950 4803 8178 PMC6854528__F2 Model of the AhR signaling pathway 196 405 1543 57491 718 PMC6856008__F6 MicroRNA Regulatory network with miRs from the anti-survival/EMT group 4170 324 2149 2260 84133 7477 5728 7534 7479 208 7422 7099 114609 5602 80319 2791 5970 6850 8322 4915 25805 4776 4193 331 7185 3929 4067 7143 3480 3915 3575 6654 5336 8915 55970 4773 5579 8517 4099 PMC6857536__F2 Role of Ras pathway proteins in exo-some biogenesis, cargo selection and release 1950 1956 6667 5062 2885 5879 6010 998 7018 PMC6858945__F1 Outline of the molecular pharmacology and response determinants of clinical TOP1 inhibitors 7150 29940 55775 91607 4361 545 1111 PMC6859529__F3 UPR pathway under ER stress 83939 7494 468 PMC6859529__F5 Redox regulation of apoptosis under ER stress 7186 581 83939 468 637 PMC6861177__F1 Mitochondrial quality control 4976 7019 4899 PMC6862519__F3 Schematic model 406928 846 359 361 360 551 1636 PMC6862746__F9 HCC microenvironment inhibits SIRT4 expression in TAMs and modulates alternative activation of TAMs, which contributes to HCC development 8205 6774 383 23409 619501 PMC6873590__F1 Glycolysis and biosynthetic pathways emanating from glycolysis 2539 4397 5226 4524 2597 100187761 4522 5723 6470 6472 2731 7054 10797 441024 PMC6874141__F1 Ras signaling pathways 5914 83593 1956 4485 PMC6879798__F1 InterferonB signaling pathway regulated by RLRs 7706 57506 7187 10010 PMC6881378__F11 Proposed mechanisms for the role of MC mediators in response to tumor cells 1356 5111 51083 PMC6883191__F2 Evaluation of the immunobiological effects of a regenerative far-infrared heating system in pigs 3929 3458 7099 929 23643 7189 6772 4615 PMC6889380__F2 Haem synthesis pathway 210 2235 7390 9429 5498 7389 PMC6899527__F3 Single-Cell Sequencing of ChAT/vAChT-Positive Cortical Cells and Analysis of Their Expressed TranscriptsExpression values were normalized (0–1) for each dataset 7018 1137 4915 146713 2571 7432 43 1131 1128 1141 1103 1271 3977 1139 6750 26468 1129 590 1138 2670 1136 1132 116448 145270 4914 7080 8973 1142 8292 6572 1133 1143 199 2636 431707 2637 3670 57053 1135 4804 60482 3570 3572 3976 1270 3716 3717 7297 9575 PMC6902440__F2 TGFB1 effects on the balance between the canonical WNT/Beta-catenin pathway and PPARG 22943 324 4087 4088 1499 4089 4040 4041 PMC6902440__F4 Interactions of TGFB pathways, WNT, Smad and the Hippo pathway in fibrosis 4485 9113 26524 5728 PMC6907741__F3 Regulatory Mechanisms of B7x Expression 4089 4088 6774 5970 PMC6909129__F1 Pattern Recognition ReceptorsThe anti-adenoviral immune response is triggered by recognition of pathogen-associated molecular patterns (PAMPs) by PRRs 7099 64127 4615 54106 7189 3606 3665 3661 115004 PMC6909960__F1 Multiple factors regulate COX-2 expression 4803 4615 1956 3654 7186 196 11140 405 5743 51478 PMC6912266__F1 Potential intracellular target points for (i) acute alcohol and (ii) chronic alcohol in a stylized cell 3929 4050 958 7189 4615 3654 51135 5971 5966 4353 114548 PMC6913305__F4 Regulatory network of transcription factors in OA includes dark green quadrilateral module and light green rectangle module 5241 1482 3205 4209 1499 2101 1385 3206 6778 23462 1386 689 468 1959 5966 25 51147 6772 6774 2033 2118 3198 472 6721 6773 3725 672 4790 23030 1050 9314 79923 1958 5970 10365 7528 4602 7494 2295 6688 2113 5993 5925 2146 26471 8625 3159 5449 7421 55809 27086 5994 6667 2114 3091 7392 864 PMC6927352__F5 Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH 387 5879 7006 100124696 399 3683 3689 3684 7070 7408 928 4023 960 7450 1101 948 6420 961 PMC6927982__F7 Predicted pathway illustrated that IL1B and MALT1 were significantly upregulated in the NF-kappa B signalling pathway 10892 4615 51135 3654 4513 7189 PMC6928102__F5 Correlation network between the significantly changed metabolites and proteins of the hypothalamus in the LPS group compared with that in the CON group 8975 9776 54785 3281 80153 51155 28956 2887 5819 5613 23580 9828 6091 2678 5775 5800 7922 192111 9677 1103 1947 1392 9747 5730 25970 PMC6928102__F8 Proposed model of the EPHB2 signaling cascade that regulates the synaptic plasticity through the phosphorylation of AKT under neuroinflammation-associated perturbation of glutamatergic transmission 2744 2571 1947 627 PMC6935177__F9 Working model demonstrating the regulation of Hippo signaling during ovulation 4485 9113 26524 6770 PMC6941297__F1 Protein expression, molecular pahtways, facilitators and mutations involved in the genesis of brain metastases from melanoma, breast and lung cancer 673 1956 7153 2571 100124700 6010 9817 23132 7157 7852 6387 50614 83987 646 1520 367 2475 PMC6941795__F2 Metabolic adaptation and maladaptation in adipose tissue 367 7350 948 63976 1734 1149 1386 6262 90550 PMC6944231__F3 Pathway analyses of significantly altered proteins by IPA 2775 3737 6844 2773 9342 6616 9545 5898 9783 2785 11258 1114 4780 6558 9817 10160 7447 6857 PMC6948191__F3 Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies 1019 9118 9447 115004 57506 7098 51311 51284 54106 834 4615 3661 3665 PMC6952374__F7 Role of ALK5 and non-canonical androgen signaling in ADPKD 165140 222545 4087 4088 PMC6955783__F5 RNAseq genes associated with NRF2-mediated oxidative stress response via IPA® 2444 4094 571 2353 5052 2512 2495 10963 10574 8192 2729 10961 3725 11243 PMC6955783__F6 Hypothesized pathway and consequences of glutamine uptake in 2 h post METH STR microglia 81539 6510 55238 9057 6507 2744 2752 6506 2746 2729 6647 2937 23657 847 493869 PMC6957738__F1 ERBB and signaling effectors in PKD 1950 1839 7039 2064 1080 6714 2885 7175 5728 551 359 PMC6958341__F5 Overview of the metabolic pathway changes in murine 3T3-L1 adipocytes due to insulin or TNFA treatments 3991 95 355 6647 3329 4728 4513 91942 6648 3336 4697 1346 4716 7381 140823 PMC6959074__F2 nAChR-mediated signaling pathways that lead to lung cancer progression 1950 1956 6714 5894 3717 6774 1869 10413 114548 1958 4615 6657 6667 2623 2247 PMC6962108__F1 Mechano-sensing by LSECs drives fibrotic processes 9780 10413 3280 23462 PMC6964678__F2 Cancer cells obtain fatty acids (FAs) from de novo lipogenesis and exogenous uptake 355 948 55902 47 3417 3418 9415 6319 27165 PMC6964678__F3 Lipid metabolism by PI3K–mTOR signalling 5163 5728 7249 7248 65220 2932 47 6009 55294 6446 6733 2194 55902 PMC6974395__F3 Fumarate hydratase in cancer: a multifaceted tumour suppressor 50 2271 27247 51027 388962 23479 9817 2242 PMC6976991__F4 Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications 3643 2152 1571 847 51094 43 PMC6978262__F2 Related miRNAs and target genes/pathways that regulate autophagy 23621 9140 9474 79065 10533 83734 407040 2475 23411 407053 PMC6987486__F2 Mechanisms of how Sfrps modulate cellular apoptosis, angiogenesis, differentiation, inflammatory process, and cardiac remodeling 6423 6424 355 89780 3082 595 1499 7124 3586 649 51176 PMC6989439__F2 Cellular-mediated rejection 961 140885 6503 324 PMC6993871__F6 Simplified schematic of the cholesterol biosynthesis pathway and MARCH6 targets 3156 4047 1718 10682 1717 PMC6994220__F1 cis-carotene biosynthesis and regulation of PLB formation during skotomorphogenesis 5447 55070 1380 PMC6995173__F7 NAMPT’s role in the proliferation of human CRC cells through the regulation of Wnt/Beta-catenin signaling 324 1499 10135 PMC6997353__F2 Ferroptosis: past, present and future 9817 3652 2879 6303 3315 2182 4015 10162 55240 8031 3658 10533 9474 23657 246 PMC6997384__F1 Erythropoietin and its derivatives: from tissue protection to immune regulation 2056 3566 7175 3717 3716 3718 6774 383 4240 10461 948 2621 6347 6356 2919 6348 1051 6778 PMC6997396__F5 Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system 7248 7249 2475 7038 PMC7000272__F1 RELA interactome 7422 3576 4854 8878 64127 6648 27035 596 5971 1999 1499 5970 6662 4791 3091 4790 367 841 7291 602 1869 5347 1540 2309 PMC7002996__F5 KEGG pathway analysis of the p53 signaling pathway regulated by PCA 1019 472 545 355 637 581 4609 836 94005 4193 64065 84883 7249 5728 64326 6477 PMC7003858__F4 Signaling in T‐cell activation and PD‐1–mediated suppression 324 940 3932 7535 5163 3702 PMC7005297__F1 Wnt/Beta-catenin pathway in cancer stem cells 4040 4041 100302142 324 2932 664613 27123 7074 51339 2146 10131 6932 4609 960 4316 5376 8549 64754 3202 7015 7008 PMC7007672__F3 Molecular pathways in embryogenesis of the liver 6926 999 9480 1050 3172 3087 5629 4089 2626 PMC7010578__F4 Major pathways and genes related to major depressive disorder (MDD) 2885 7039 2064 627 4914 4915 1398 10818 7851 9575 1813 1812 2898 836 PMC7016711__F4 Central carbon metabolism 1571 3091 2744 2597 26227 2023 5165 5723 11113 1431 5091 2271 4118 PMC7016889__F1 General view of glycolysis 2821 226 7454 2597 5230 5223 100187761 PMC7017041__F4 PARylation is required for chromatin structural changes following DNA damage 472 200558 142 10038 3014 7703 1108 2146 1107 9112 1106 9025 PMC7019133__F1 Canonical Wnt/Beta-catenin pathway 4040 4041 324 1499 PMC7019133__F3 Role of sFRP2 in cardiovascular disease 6423 7855 847 PMC7019324__F2 Extrinsic and intrinsic apoptotic pathway 8772 8717 4975 637 PMC7019324__F7 Routes of the complement system with its inhibitors currently studied in kidney transplantation 716 720 721 717 1431 727 730 735 PMC7022557__F1 PI3K-Akt signaling pathway 3630 2475 596 581 PMC7022878__F10 Summary suggesting the mechanisms of LUT attenuated hepatotoxicity induced by PbAc 9817 6648 3603 847 2876 4843 2936 PMC7026059__F5 Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway 1431 8803 3240 PMC7037210__F1 Main anticancer molecular mechanisms mediated by cannabinoid receptors’ activation “↑, upregulation” and “↓, downregulation” 1499 999 6714 572 387 2475 581 468 PMC7037245__F2 IL-2R signaling and modulation of T cell activity 3558 10125 5163 3716 3718 6464 2885 9846 1977 1975 6776 6777 50943 8651 639 2002 PMC7037626__F1 Protein interaction network of MMPs, collagen II and aggrecan 9313 9510 1101 4327 6387 3958 176 3674 2335 5549 56547 4313 1401 4060 6678 4099 4326 650 7077 7369 356 5118 1839 3685 4155 4314 63827 7143 857 9507 4803 1404 4018 5329 5858 PMC7037737__F5 Interactions between the WNT pathway and aerobic glycolysis in exudative AMD 4040 4041 2932 1499 3939 324 PMC7038167__F5 Graph of genes and processes involved in the pathway 04110: Cell cycle 4089 4193 6502 991 699 9184 5111 1022 1017 990 999 4661 1874 1869 10926 23595 4999 PMC7045519__F3 Epigenetic regulators in ferroptosis 875 102465513 9415 79968 1994 10146 8314 PMC7046305__F7 Anti‐tumour mechanism of Tan‐Ⅰ 581 2475 10533 PMC7047255__F7 Pathway interaction schematic constructed to demonstrate overlap of gene expression data with critical osteogenic pathways 5727 6608 659 1499 2932 4090 4086 2737 2735 3092 4488 860 121340 632 6696 9242 PMC7052372__F2 Innate immune receptors present in cholangiocytes 4615 7099 3654 51135 7098 3661 57506 114548 PMC7053098__F5 Cisplatin-induced P53 signaling pathway genes are differentially expressed between Sirt2-deficient and Sirt2-proficient cells 10090 1017 472 545 637 4609 842 836 7249 5728 64326 6477 PMC7054714__F3 Immune Responses to Viral Gene Therapy Vectors 3458 941 942 940 920 958 3454 3553 4615 54106 5132 PMC7056731__F3 Mutual activation of Hippo-Yorkie pathway and Toll/IMD mediated anti-bacterial response in Drosophila 4615 8772 23118 PMC7059351__F2 Alteration of synthesis and degradation pathways of glycosphingolipids in the physiopathology of HSP 2583 2581 410 57704 170 PMC7062835__F1 Molecular network identified using the “Interaction search” algorithm in KeyMolnet 203068 2782 2783 22924 3208 5595 324 8682 156 55022 213 1152 5594 5602 6622 63908 203 4609 11315 7157 2820 6955 387 5578 3728 5162 PMC7068214__F7 Investigation of the Genome-Wide Genetic and Epigenetic Networks for Drug Discovery Based on Systems Biology Approaches in Colorectal Cancer 5753 55620 25852 4583 7157 55254 6096 54361 2774 442894 2668 10592 9262 4097 27306 2895 6935 869 90806 196 416 81611 6678 3980 28227 6769 10785 9121 22875 2814 2040 7450 PMC7069061__F6 Pathway of multiregulatory effects in Chinese medicine 3458 356 3565 3586 6373 2919 1950 3558 3569 3562 3567 3574 7173 7422 3627 959 1956 6714 5728 207 387 1499 2002 5894 5594 3479 4803 7097 2475 4312 4314 581 10743 836 54115 596 PMC7069124__F4 Overlaying the consensus TLR4 signaling pathway in databases with HemeKG (A: original overlaid network, B: overlaid network after inclusion of literature evidence for effectors) 3635 11213 7124 8517 929 3553 10454 3551 3569 1147 23118 257397 4792 114609 51135 7189 7099 4615 3654 3656 958 941 4133 5604 5606 4135 942 9053 6416 5599 3576 3665 4283 3627 3661 7187 6373 5594 PMC7072180__F4 FUT8 overexpression promotes DNA replication 6119 4118 2530 5111 1017 PMC7072240__F6 Cooperative regulation of genes involved in glutathione (GSH) and NADPH synthesis by Nrf2 and ATF4 2539 440 2729 1491 2730 26227 29968 5723 875 2937 4522 2936 5183 6472 10797 468 PMC7072559__F2 Metabolic pathways contributing to glutamine addiction in gliomas 2475 5091 3417 2875 PMC7073155__F2 BPA action on placental growth 7472 596 1583 PMC7074533__F3 The vascular smooth muscle contraction pathway 779 808 85366 4638 91860 3778 30814 4629 59 148 183 1909 369 5894 5595 800 2767 72 1906 2776 5578 5581 5499 4659 551 2768 9475 6093 387 135 108 796 133 2778 5566 5739 10266 115 3708 4878 4879 4881 5592 4882 2977 2974 1908 4880 805 5605 10268 5319 5332 PMC7075814__F4 Signaling via the non-canonical pathway of TGFB 57154 2475 7189 387 PMC7080523__F4 Innate immune regulation of cGAS‐STING‐mediated immune pathways by the host or viral elements 7297 3716 115004 3661 940 941 4615 3665 3050 3428 PMC7082839__F7 Diverse APJ signaling pathways activated by prolonged mechanical load or apelin 2475 6262 5350 PMC7084279__F7 Detailed analysis of the 13 out of the 23 screened genes in “monoamine GPCRs” pathway 1812 3350 148 3269 1128 1813 3351 3274 1129 1814 3352 1131 1815 3354 1132 1816 3355 1133 3356 3357 153 3358 154 3360 155 3361 3362 3363 PMC7084352__F1 Simplified scheme of L-arginine/NO pathway 3276 3275 10419 23564 23576 4843 5009 383 384 435 4953 PMC7084352__F3 Alterations in expression of L-arginine/NO pathway enzymes in inflamed and quiescent tissue from patients with Crohn’s disease as compared to normal small bowel tissue derived from patients with ulcerative colitis 3276 3275 10419 23576 23564 4843 383 4953 PMC7084352__F4 Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings 3276 3275 10419 23564 4843 383 4953 23576 384 PMC7084447__F3 An illustration demonstrating BER 6741 4968 79661 252969 142 11284 55775 5423 5111 5426 7515 2237 3978 PMC7090218__F2 Metabolic pathways affecting ferroptosis 8031 23657 9474 10533 2539 5226 3315 3658 55847 2879 10162 100 2182 PMC7093422__F6 Detailed information of sub-pathway (AGE-RAGE signaling pathway in diabetic complications) in the KEGG 7046 7040 4089 1536 3265 3725 5578 177 113026 2277 5879 595 1729 6401 7412 4772 5290 3717 6774 3383 10000 6772 4313 5292 4790 3552 1277 3569 7124 2152 836 581 2308 596 PMC7096153__F2 Ingenuity Pathway Analysis 5524 391013 5048 2977 2744 2775 6507 2911 6506 2915 2912 2913 2890 10000 6262 2892 4208 3845 5594 5579 2776 23236 5581 107 815 4205 488 5602 5609 10746 2002 777 10971 776 4209 5074 673 PMC7098936__F1 Drugs in development for the treatment of achondroplasia 2261 2247 1267 10818 2885 PMC7103888__F2 Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders 8239 64854 9097 219333 8975 23032 1641 6091 9101 6585 9353 57602 7375 7874 6772 11274 23326 10713 4615 84196 7189 1540 PMC7105607__F1 NFKB signaling cascade 7124 7099 958 7186 7189 7187 10892 8915 23118 257397 5971 PMC7105607__F2 Impact of NFKB on MS animal models 1878 8178 5971 PMC7108750__F3 Signaling pathways coordinating the hepatic regenerative response 471 6469 84976 3569 3082 1950 54894 6608 5727 4040 4041 55366 8549 59352 1956 1499 4485 2932 9113 26524 324 5728 2475 80004 595 983 4771 PMC7116639__F5 Regulatory R-loops as effectors of gene expression and genome stability 5888 672 675 79728 5893 246243 1653 545 PMC7129915__F1 Summary of antiviral signaling pathways in chickens 7099 114609 7097 7098 51284 3455 3454 57506 100187907 10379 3665 PMC7136022__F4 PGE2 signaling pathways 4513 6714 2932 PMC7136425__F8 Compound BA-5 inhibits HSCs activation through blocking both TGFB1 and LPS-induced NFKB signaling pathways and further inhibits macrophage recruitment and activation 7099 25805 4087 4088 4089 1278 3383 4615 PMC7137223__F2 MiRNAs-mRNAs regulatory network 53904 5451 8243 10723 5933 23336 10749 5724 8675 6452 6095 5814 7851 5717 80323 2185 116835 4288 23463 1582 5316 7170 221937 54811 81609 5865 22877 23545 1983 376267 6745 1073 9761 26036 10238 2802 378108 6483 202243 23467 56970 5578 11237 79856 55670 91369 27115 23031 346389 2055 56886 57085 4771 84775 59283 11118 54858 728116 11056 4943 261729 375593 84868 602 2113 24141 7275 8570 51545 163590 119 2914 5479 6158 79180 23201 81839 116236 9831 3177 9609 6399 10776 7477 83931 64077 100289678 7534 4627 148254 23060 222553 PMC7137223__F3 Integrated protein-protein interaction network in present study 10723 4299 116835 23099 23336 5479 753 4288 57713 51128 5451 3177 2113 6399 6095 8243 8675 5316 83552 53904 116236 9609 6310 602 79180 222553 119 9761 91369 5573 7029 26034 340554 5724 9852 81609 6452 27115 148254 376267 2802 4881 7534 8570 23211 57085 100288797 114826 26036 3480 84133 202243 11118 2035 50940 10776 5717 23097 79856 83931 7477 55670 4627 5578 23467 2185 57761 2947 6506 23463 54811 5170 10163 7275 59283 7170 11237 221937 23201 10749 4771 5831 261729 79094 26259 5865 80323 128989 23060 3996 254158 6158 5129 378108 375593 2935 54858 5814 6473 56970 137886 23155 51621 23241 100289678 51545 PMC7137223__F4 CeRNA network in this study 83552 602 11213 23060 23241 3177 5814 4771 84133 6473 10425 26259 79180 5865 1073 9852 57761 6452 2947 26036 11118 7048 51545 5129 22877 202243 64077 5831 91369 79856 10238 119 116236 9761 11056 114826 2185 7170 55037 221937 6483 7851 3996 261729 57085 79016 10163 51621 23545 10749 4627 6158 7275 23097 9715 6506 3480 5170 10776 388552 8570 81786 4881 7534 11176 4194 100289678 100288797 169611 9796 84868 55007 55670 23467 7029 27115 5578 2035 5143 9831 23096 23211 9609 8243 8675 81609 114804 6310 5933 5724 5316 340554 5361 6399 5573 10723 53904 4299 10984 57713 23099 104472715 25829 24141 26994 116835 100533955 5479 2113 389856 4288 23336 PMC7139827__F1 Endoplasmic reticulum (ER) signaling pathway and the ER–mitochondria pathway triggered by natural compounds 22926 7186 83939 468 PMC7140412__F2 The autophagy molecular pathway and target steps of its modulation 9140 6009 2475 64422 22863 9706 55626 10533 9776 7405 2308 PMC7140443__F4 Role of SHH/Gli cascade in Ewing sarcoma development 6469 5727 6608 51684 2313 2735 PMC7140616__F1 Fates of Beta-catenin, when the canonical Wnt pathway is not activated 11197 999 1499 2932 324 2195 PMC7140716__F1 Role of ARTS and Smac in induction of apoptosis 8717 8772 7186 331 637 PMC7140716__F2 Models for Smac-mimetic (SM) and ARTS-mimetic (AM) mode of action 8772 7186 7187 8717 8737 331 11035 5971 100187761 PMC7146499__F2 Dehydration alters hippocampal transcriptional networks 2891 814 3098 2582 3939 2548 5649 5211 5837 4155 161882 1843 10777 8864 51144 25822 64651 7054 2572 55974 627 116372 6478 3164 8553 6624 134218 2820 23237 2353 90007 8831 9229 4099 1739 3654 3726 348 7422 1595 6386 6714 551 1742 1740 8573 7832 1961 9463 9378 55607 148523 150094 4301 54413 8997 PMC7146513__F1 Specialized Pro-resolving Mediator (SPM) synthesis pathway and receptors 2358 2854 2861 PMC7151642__F2 Independent functions cGAS and STING 115004 29110 3661 5970 472 PMC7155254__F4 ERS and oxidative stress in patients with NAFLD and the generation and crosstalk of ROS signalling connecting these pathways 3667 8660 1571 7494 317 468 596 7186 PMC7156871__F3 MicroRNA (miR)‐302/367 family participates in networks that regulate cancer hallmarks 442912 26524 1956 6263 51715 3480 7852 207 208 54165 6382 4170 983 6935 581 1871 595 894 7026 1003 92140 100507436 4277 PMC7158223__F2 Post-transcriptional regulation of stem cell identity under conditions of stress 3297 22926 7494 468 4553 1998 PMC7159149__F6 Commonly dysregulated genes 1950 939 3605 100188864 4049 9532 958 8717 51295 5891 2475 6774 324 197 1401 1431 3273 PMC7166181__F3 Signaling Pathways Regulated by PI3K/Akt/mTOR that Promote Neuritogenesis: A variety of ligands lead to neurite initiation and elongation through PI3K/Akt/mTOR signaling 467 4803 627 3082 6093 2932 4133 2475 324 253260 998 5879 PMC7166201__F1 PTEN, a PAK1-blocker, interferes with coronavirus –induced PAK1-dependent signalling pathway leading to lung fibrosis 5728 59272 6347 5058 PMC7167271__F11 Effect of RPMP and emodin on genes expression profiles 208 51 7038 PMC7174132__F1 Epigenetics/Epigenomics of Triterpenoids in Cancer Prevention and in Health 3569 6927 4209 10413 26524 3172 7124 900 4087 4088 7040 6667 6935 2146 1000 1786 864 65986 6670 50507 6671 5927 1788 7015 142 4615 3066 4780 PMC7176443__F3 Functional lncRNAs in signaling pathway 139728 105416157 5970 387 647979 998 55384 5879 283120 PMC7181472__F5 Kunxian capsule in treating RA 2475 6774 6095 7189 7124 PMC7183768__F8 CREB signaling in neurons in response to granisetron treatment with the IPA molecule activity predictor 2885 6908 2002 PMC7186400__F5 Paraburkholderia sp 2936 727 729 100187907 PMC7191303__F1 Hippo–YAP1/TAZ pathway in cardiac biology 154810 79633 10413 4771 60485 4485 3084 9113 26524 2066 8289 PMC7193097__F4 Schematic model presents the effect of tea polyphenols (TP) in attenuating STS-induced cytotoxicity in hippocampal neurons 412 627 440514 PMC7193283__F4 Mechanism of emodin on improving NAFLD 2475 468 4087 83939 7038 7099 PMC7202451__F6 Gene expression of the ILK Signaling pathway in the hepatic transcriptome of S 5728 8440 253260 5163 5829 6251 836 2475 4666 100188835 2353 6010 1832 3875 7431 4609 4318 650 4513 PMC7202451__F7 Gene expression of the signaling by rho family GTPases pathway in the hepatic transcriptome of S 8505 5585 23191 85502 1384 2670 PMC7202519__F7 Our hypothesis that exercise training suppressed inflammatory and apoptotic pathways and enhanced IGF1R/PI3K/Akt survival and anti-aging AMPK/SIRT1/PGC-1A associated pathways in the hippocampus of D-galactose induced aging rats 355 3480 8772 23411 4513 6648 PMC7214667__F1 Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) signaling pathway and its inhibition with jakinibs in synovial fibroblasts 9180 5008 7124 3717 7297 6772 6774 6773 9021 4312 4314 4283 3627 6373 10401 PMC7214843__F2 RAD51-mediated RF reversal (A) and an overview of replication fork restart mechanisms (B) 5888 1763 7486 10714 80198 5111 PMC7215285__F3 Metabolic pathways including glycolysis, pentose phosphate pathway, tricarboxylic acid cycle, and lipid synthesis with target non-coding RNAs 3099 9759 5226 2539 7086 3939 47 2271 PMC7226501__F8 Regulatory model of VP4 in antiviral signaling in grass carp 29110 3661 3665 4615 PMC7227004__F1 YAP/TAZ activity is tightly regulated—Hippo signaling and beyond 4485 60485 9113 26524 1956 864 860 865 1958 2066 PMC7227439__F1 Role of metformin in VSMCs dysfunction 2475 6502 3428 860 5166 PMC7230342__F4 2-step DSB repair pathway choice model [,,] 472 7518 675 5888 PMC7232545__F1 Anticancer mechanisms of matrine 1950 7186 4041 1956 1499 2475 637 3146 8678 572 331 9140 9474 5728 841 842 836 839 5111 2932 840 3717 1021 1019 1017 6774 51176 4318 4313 PMC7233810__F5 Apolipoprotein A-I anti-tumor activity targets cancer cell metabolism 3156 4598 10654 4597 3652 6713 4047 388 51478 1718 PMC7236859__F1 Proposed mechanisms of exercise cardioprotection 3479 2066 2064 367 PMC7238533__F2 Role of Fbln7 and its C-terminal fragment in the modulation of cellular functions under physiological and pathological conditions 129804 4312 6772 6774 5879 387 8205 PMC7239059__F5 SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing 11064 1312 8453 4015 7113 1636 875 PMC7241259__F2 Wnt pathways 1499 999 4040 4041 2932 1386 387 57216 4920 PMC7242326__F9 Summary of the role of AHR ligands in blocking TGFB induced collagen deposition and myofibroblast formation in Thyroid eye disease 196 4312 405 PMC7243120__F1 An autoregulatory loop controls Proline biosynthesis 468 54407 4553 5831 5832 83939 PMC7243768__F2 SARS-CoV-2 enters into the host cell via binding with the cellular receptor ACE-2 3627 324 7187 51135 7189 114609 PMC7248192__F2 Hyperglycemia-induced oxidative stress impairs nitric oxide signaling 7412 3383 2597 10628 114548 3603 PMC7250567__F6 Proposed model of K. pneumoniae-stimulated signaling pathway 140885 8935 6850 PMC7256186__F1 Warburg effect in melanoma cells caused by BRAFV600E mutation leading to constitutive activation of MAPK pathway 4609 4286 5230 2023 3099 PMC7258858__F1 Actions of thyroid hormones (THs) and their corresponding receptors 6476 2147 2022 27121 5292 4602 1017 619501 2308 5045 1512 595 1499 6298 4280 PMC7260844__F1 Schematic representation the regulatory networks of lncRNAs in major biology activities during brain developmental process 283120 55384 1499 650 84678 2932 10215 23512 4781 283131 105447646 378938 9839 6935 497258 627 347689 103157000 652995 3280 100124700 PMC7261103__F2 Role of renin/angiotensin system (RAS) and kallikrein/kinin system (KKS) in pathogenesis of COVID-19 5340 1636 59272 367 7113 PMC7261485__F9 ATP11B deficiency leads to impairment of hippocampal synaptic plasticity 23200 9900 6855 1742 1432 23237 PMC7264474__F1 Ceramide and Sphingosine 1-Phosphate in Liver Diseases 10715 253782 91012 204219 29956 79603 6696 6694 56848 8877 95 PMC7266379__F1 Loss of MAP3K7 sensitizes prostate cancer cells to CDK1/2 inhibition and DNA damage by disrupting homologous recombination 100187907 1105 6885 6198 5706 6241 51547 54107 6240 5888 5718 3066 4609 7174 5719 351 10213 1111 10105 5471 203068 4524 6844 7298 5427 5692 5702 123263 4860 5715 5694 9212 6790 1719 983 51174 1725 7283 10038 90411 1491 29893 6472 471 64223 1017 3251 1019 1147 56655 2 2157 5691 332 4522 1374 11200 1429 4048 5426 5721 5465 293 27032 3065 55627 7153 6470 2643 2805 1786 3832 5347 4547 3094 23649 3026 292 2230 1723 1376 51091 55851 1062 9641 2752 3614 4827 PMC7270529__F3 IPA’s individual pathway analysis of different proteins from the different experimental groups, linking them to a suggested promotion or inhibition of a cellular event under the umbrella of inhibition of cell death or change in cytoskeletal activity 2778 301 3326 387 5743 3688 2181 5901 57142 7416 6950 9868 60 3320 6712 5499 676 7431 10273 1431 5829 2664 25978 4609 240 5732 5734 11331 3276 706 PMC7273358__F6 Metabolic rewiring of the hypertensive kidney 587 1632 1738 1629 1645 34 35 3712 1892 1962 51 549 26275 759 18 3028 38 39 197322 4852 11340 50943 5617 3082 57521 2641 2353 23373 7555 2309 2720 2185 26291 3859 6622 5621 2034 54205 7040 4282 3827 2475 2006 6035 6010 7170 2194 3725 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3954 8671 948 7045 7384 762 173 4694 51079 25874 2822 32 4718 55005 5444 7276 2267 7837 3419 5224 3420 949 6288 1158 203 8165 5265 2820 2597 PMC7285601__F1 Simplified schematic of pyrimidine nucleotide synthesis showing enzymes targeted for cancer therapy 2030 9154 3177 9153 55315 64078 1806 7372 1723 56474 978 790 1635 1283 PMC7286818__F2 Emerging roles of WBP2 oncogene in human cancers 89780 2932 324 1499 4485 60485 23558 26524 9113 2023 9454 3725 8313 23043 8312 PMC7287162__F7 Key components of the melanogenesis signaling pathway 4157 4286 6663 PMC7291288__F4 ER stress is involved in NLRP3 inflammasome activation 114548 5966 3553 PMC7293224__F7 Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway 2475 64422 10533 PMC7295046__F9 Schematic illustration showing the proposed mechanism by which FABP5 promotes LNM of CCa by regulating FA metabolism 2171 2194 4099 7291 7424 4318 PMC7299722__F1 Effects of doxorubicin on cardiac mitochondrial dynamics and mitochondrial function 9927 51024 4976 PMC7306092__F2 Activation of pathways triggered by hyperglycemia to induce TSP-1 expression 406938 6667 1869 1958 PMC7306092__F3 Progression of fibrosis caused by expression of ECM proteins after activation of TSP-1 961 948 6010 4089 PMC7308426__F5 Calcium signaling pathway 90550 5350 2040 859 613 1610 213 857 776 84876 PMC7310537__F6 Phosphorylation of HH pathway components after 15 min treatment 51684 9742 5710 56623 5707 5578 5576 8100 109 6608 5566 5717 6295 2121 2736 2475 156 26160 8452 PMC7311357__F1 Illustration of the main components of the ACE/ANGII/AT1R and ACE2/ANG(1–7)/MASR axes along with the other molecular components reported to be involved in SARS-CoV-2 infection (e.g 1514 1508 1636 183 59272 7113 5045 324 PMC7311976__F4 Ubiquitination in the Wnt signaling pathway 84133 54894 4040 4041 4734 83737 6477 324 10075 81847 57154 57664 64750 1499 55120 79960 26502 PMC7312214__F1 Innovative Potential of Statins in Cancer: New Targets for New Therapies 3652 595 581 5728 1019 596 23071 4609 999 6010 2475 4318 51684 6469 2735 79923 PMC7312607__F7 Enriched pathway maps 7341 4088 2288 4792 10499 1051 2353 6774 3458 156 3066 85451 6010 23426 3725 847 5144 PMC7313221__F4 Main mechanisms involved in the development of HCC 7099 7908 4615 1571 619501 PMC7314312__F2 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism 65220 10628 5208 7086 790 47 5163 PMC7314312__F5 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism 3417 2539 65220 47 2194 4693 1719 PMC7324530__F1 PI3K/Akt pathway in health (A), cancer (B) and AD brain (C) cells 4035 3667 5728 51527 PMC7327152__F1 Deciphering Macrophage Phenotypes upon Lipid Uptake and Atherosclerosis 3553 948 3458 4615 114548 6772 3383 6366 6347 729230 1234 7412 19 9619 PMC7329534__F8 Pathway analysis A) Pathway analysis for upregulated (a) and downregulated (b) miRNAs and their respective mRNA targets 6712 25791 11313 25 10006 7277 9353 10371 8985 23129 8976 91584 5603 5293 5747 3690 55558 5599 5578 2045 667 5361 10451 9046 1290 1282 7373 2043 2932 1808 85358 7837 1281 5649 10154 2046 80031 1280 55740 26018 2264 51107 23543 23032 8650 10000 2069 9475 5217 90249 2260 5962 1457 2904 53916 5437 161742 3680 1956 5295 253260 1600 3082 7423 5829 10818 5604 6711 1947 5979 7846 4734 2885 161 160 558 3643 1843 7422 10750 1848 10193 5594 1846 8569 801 51231 2889 5045 29924 11059 1849 10458 857 80824 3667 1852 1729 5519 627 523 5774 7867 1845 5170 4915 5795 1111 4486 23163 PMC7330710__F1 Representation of some of the metabolic adaptation and reprogramming of cancer stem cells 2539 7971 2194 4190 2805 2806 PMC7333890__F2 Stress responses to aneuploidy and radiation 545 472 2539 PMC7340853__F1 Clinical promise of next-generation complement therapeutics 1356 10747 5648 715 718 716 720 2271 1604 1378 727 4179 27202 729 730 735 966 PMC7343820__F8 AChR antibody-induced effects on myotubes expressing AChR clusters 4038 4593 55384 PMC7344784__F5 Activation of ATM signaling predicted by IPA-based pathway analysis 472 100187907 3014 1386 4193 6935 9656 637 545 1017 PMC7346118__F3 Pathways involved in polymyxin-induced nephrotoxicity and the potential nephro-protective mechanism of curcumin 355 50507 8772 PMC7346762__F2 TrkB signaling-mediated cell survival and the Nrf2-ARE antioxidant system 627 2885 2549 4094 PMC7347881__F7 Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling 4613 4609 7157 5156 546 1616 28514 429 63973 100188776 388585 3516 9610 PMC7349567__F1 Regulatory metabolic pathways of ferroptosis 7018 6510 3156 2744 55240 2182 3652 2879 6520 23657 8031 PMC7349686__F2 Possible signaling mechanisms of ectopic osteogenesis in skeletal muscles 10454 4090 4086 4087 4088 1499 4089 9759 10014 860 7039 3397 PMC7351732__F3 MYC regulation of essential amino acid and lipid metabolism 8140 8501 6510 125061 8564 8213 11113 47 8942 3156 2194 PMC7351732__F4 MYC coordinates multiple metabolic events to activate nucleotide metabolism 8833 3615 3614 383 4975 6723 6611 1723 5471 4548 5723 5634 29968 7086 2539 26227 790 PMC7351826__F7 Hypothesis that Sal B protects myocardium through inhibiting the expression of HMGB1 via activating PI3k/Akt signalling pathway in myocardial I/R injury 3146 581 7099 PMC7352559__F2a Klotho and the Treatment of Human Malignancies 9958 7375 3667 4087 4088 64750 4092 324 2932 4089 2475 1499 PMC7353140__F1 Features of the nuclear envelope and ER and regulation of and functions for lipid asymmetry at the inner nuclear membrane (INM) 23399 55746 5091 PMC7353358__F2 Phytochemicals activate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway 9817 8452 196 PMC7354287__F7 Androgen-binding AR inhibits TGF-Beta-related Pathway 4087 4088 4089 5728 5163 1499 PMC7354650__F4 Network Pharmacology Approach to Investigate the Active Compounds and Mechanisms of Musk for Ischemic Stroke 150 3630 3066 4306 54361 1812 5469 2908 3091 5447 134 4986 7421 PMC7355854__F1 Simplified scheme of the L-arginine/nitric oxide (NO) pathway 23564 23576 4843 4842 4846 383 384 435 PMC7359022__F4 Dual role of HMGB1 in chemoresistance 3146 7097 7099 4615 2475 65018 51548 PMC7364818__F7 Differentially expressed genes in the PAI-1 KO injured tendon that contribute to the activation of the canonical PTEN Signaling pathway at 2-weeks post injury 5728 80243 4099 836 23139 5163 572 PMC7371520__F2 Caspase-1-dependent and -independent pyroptosis 6010 79792 9447 3553 1687 PMC7374198__F4 General overview of the lipid metabolism in Malassezia, based on lipidomic and in silico genomic analysis presented in and 355 5091 2195 4099 PMC7374719__F3 Advances in basic research that could lead to the generation of novel therapeutics 4763 6774 4485 7462 7297 2064 3084 PMC7374820__F5 Ingenuity Pathway Analysis (IPA) of network of eight DE genes 6781 7483 8445 131578 51422 2195 1356 3875 7358 7444 4314 6874 64129 64061 26027 10902 5281 2580 5480 9520 4342 83464 1503 1854 5372 2303 PMC7376907__F1 Macroautophagy and mitophagy 2475 9776 60673 10133 7405 9474 PMC7376907__F2 NLRP3 and AIM2 inflammasome pathways 79792 9447 114548 PMC7377092__F1 ERK signaling 637 545 7465 595 2067 7515 664 472 1950 PMC7377856__F7 Proposed scheme for the possible mechanism of EA pretreatment suppresses CIR-induced autophagy via the SIRT1-FOXO1 signaling pathway 23411 2308 10533 PMC7377944__F2 Human telomerase in homeostasis and disease 7015 84186 8106 5073 167227 96764 54464 PMC7378170__F1 Possible mechanisms through which major metabolic pathways contribute to the milk fat globule (MFG) size development in the mammary epithelial cell 5662 5091 5183 10400 7038 PMC7386875__F1 Proposed mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, and coronavirus disease 2019 (COVID-19)-associated thrombosis 7113 5045 59272 7018 3383 PMC7387847__F10 Nrf2/SIKE-mediated hepatic injury induced by long-term PM2.5exposure 9817 2729 2730 847 29110 PMC7388835__F6 Gene interaction network map 11100 51186 54920 55660 7541 10096 80351 2077 54749 5595 4771 51282 23549 745 4099 23484 6010 56943 9792 51021 84908 23543 473 PMC7391788__F7 Ingenuity pathway analysis of genes/molecules that are regulated by thymoquinone in relation to Alzheimer’s disease and inflammation (A), and osteoarthritis and inflammation (B) 929 834 7099 836 3162 1017 8743 367 4683 4353 356 1019 842 6774 7124 650 596 598 PMC7392229__F6 Effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms 10274 4087 4088 4089 4193 6502 9184 991 699 5111 993 1021 1019 1017 1022 5347 999 4661 1869 10926 23595 4999 PMC7396579__F3 Glucocorticoid resistance (GCR) in sepsis 2638 1831 1843 8877 5105 7018 PMC7396672__F6 C1EIP as an activator of ENO1 to promote chicken PGC formation via inhibition of the Notch signaling pathway 6774 2023 6657 1618 1617 PMC7399071__F2 DNA repair pathways 5888 7508 5887 3978 5111 7515 5423 PMC7403229__F7 Mechanisms by which melatonin ameliorates oxidative stress via modulation of the Nrf2 pathway in cryopreserved OTs 847 2944 581 PMC7404102__F1 SARS-CoV(-2) host cell infection, replication (Phase I) and induction of immune response (Phase II) 7113 59272 3569 324 PMC7405402__F2 Cell cycle of SARS‐CoV‐2 in the host cells 59272 7113 23532 5478 51083 594857 5478 59272 7113 PMC7405480__F1 Important signaling pathways by E3 ubiquitin ligases in gastric cancer 6049 152006 51366 91445 54894 55294 7186 1499 387 6774 PMC7405837__F2 DEGs in RPE cells of the circadian rhythm pathway 5565 1407 1408 8864 9572 6097 8863 79365 9575 4618 9975 2120 8031 PMC7405837__F6 DEGs in RPE cells of the sugar metabolizing pathway 178 2997 5255 5260 5837 7360 55276 PMC7405837__F8 DEGs in RPE cells of the cholesterol synthesis pathway 3157 3156 1717 1718 4598 6309 10654 50814 6307 4597 4047 2224 6713 2222 PMC7406690__F2 Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways 4485 9344 51347 57551 5784 55233 92597 9113 26524 9686 7003 8463 7004 7005 PMC7407918__F3 Signaling pathways involved in exacerbating oxidative damage and liver injury 7099 50507 27035 929 5879 4615 3654 7186 7189 1843 1958 3553 8717 PMC7409382__F1 S1PRs signaling regulating endothelial barrier function 124976 8877 5879 9294 6010 1903 PMC7411426__F2 Targets of hsa-miR-1307 572 11021 10890 5163 5164 2308 2932 3651 7249 7248 2475 6009 3630 998 3643 6891 3667 8660 2260 PMC7415235__F2 Key pathways involved in foam cell formation regulated by microRNA 948 406890 7189 114548 9619 4615 PMC7415419__F5 Models for mammalian target of rapamycin (mTOR) behaviors on autophagic signaling pathway activation during osteoclast differentiation and formation 2475 8408 7248 7249 6009 9776 PMC7415419__F6 Autophagy regulatory signaling pathways are involved in the pathological process of osteoarthritis/rheumatoid arthritis (OA/RA) 2475 23410 23411 6009 6648 8408 PMC7415804__F1 Canonical Type I IFN signaling activated by DNA virus and RNA virus 3455 3454 3716 7706 84282 7297 115004 7186 7189 7188 57506 6772 6773 29110 4615 114609 3654 54106 51284 7098 3661 3458 PMC7415804__F2 Mechanisms of actions of lncRNAs in regulating innate antiviral response 3455 3454 84282 7297 7706 115004 101927851 57506 6772 6773 29110 7098 3661 283131 6421 3192 55601 100506668 9290 PMC7417625__F2 MALAT1 and miR-200c regulate expression of each other through the sponging mechanism 9839 999 5728 1000 PMC7418032__F6 Autophagic Clearance of Active and Damaged Mitochondria in HSCs 55210 65018 4286 7942 7030 201163 2475 7248 9140 9474 9776 55054 10533 83734 664 PMC7426447__F4 Signaling pathway for gintonin-mediated autophagic influx via LPA1 receptor 2475 3064 3916 9474 10533 PMC7432057__F1 Mechanisms involved in the effects of adiponectin in different liver diseases including hepatic I/R 2247 1401 6647 6774 7351 23411 5950 7189 355 3934 6288 4615 7099 PMC7432057__F3 Adiponectin and leptin in the progression of nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC) 619501 3717 6774 9021 2475 4312 PMC7432326__F1 Mode of 70-kDa heat shock protein (Hsp70) action inside and outside the cell 7097 50943 324 613 7099 PMC7432514__F3 Human diseases linked to eIF2 Ser-51 phosphorylation stress responses and the mTORC1 signaling pathway 2475 1998 5163 7248 6009 260431 468 PMC7432680__F1 Rewiring of Lipid Metabolism in Adipose Tissue Macrophages in Obesity: Impact on Insulin Resistance and Type 2 Diabetes 7038 7099 948 19 355 472 9619 PMC7434989__F2 Emerging roles for the IL-6 family of cytokines in pancreatic cancer 2549 2885 9021 3716 6774 10401 3717 PMC7439204__F5 Anti-ARDS pathway of YQHYJD in KEGG 1950 867 7039 367 6714 3725 4609 126669 2885 9542 2475 572 10718 145957 PMC7439808__F6 Reductive Glutamine Metabolism and Serine-Driven Folate Metabolism Suppresses Mitochondrial ROS Accumulation to Support Anchorage-Independent Growth and/or Metastatic Disease 6472 3417 3418 4522 10797 160428 25902 PMC7439842__F1 Known and speculated roles of NADPH oxidase (Nox) and ROS in G-protein-coupled receptor (GPCR) transactivation of epidermal growth factor receptor (EGFR) 1950 1956 6714 PMC7441421__F2 Signaling pathways mediated by CTHRC1 involved in the progression and metastasis of tumor 7039 324 2885 4087 4088 387 4089 1499 2475 PMC7443379__F8 Molecular and cellular basis of left–right asymmetry in vertebrates 2657 4838 4087 4088 8928 5308 10589 10637 7044 PMC7448411__F2 Use of miRNAs to combat EMT 430 100505633 283120 387066 652995 PMC7450930__F7 Distribution of the target proteins of Xiaochaihu decoction on the predicted pathways (The red nodes are potential target proteins of Xiaochaihu decoction, while the orange nodes are relevant targets in the pathway) 85451 4313 1499 4312 2932 6347 6774 3643 208 PMC7451565__F4 Genome-wide association study for mammary structure in Canadian Angus cows 10333 2047 8780 325 1401 4087 4088 8320 23569 51702 29943 PMC7456869__F4 SARS-CoV-2 in the RAAS pathway 117194 545 367 59272 1636 PMC7456869__F6 SARS-CoV-2 in coagulation 5340 59272 1636 PMC7457231__F5 Determinants of TGFB tumor suppression and its subversion in cancer 4089 4088 6659 688 999 PMC7457324__F3 Metacore analysis reveals the top scored network of IL-6 pathway 2 325 3240 6289 3716 3717 350 6774 PMC7457372__F6 Signaling pathway by which C2S NPs promote osteogenesis through an autophagy effect 2475 8408 8878 1499 10533 64422 PMC7460590__F2 Overall signaling cascades, including the TGF-beta SMAD cascade (reproduced with permission of Reactome Pathway, Fabregat et al 6010 2475 2056 PMC7460590__F4 TSP-1-CD36 signaling is inducing apoptosis of tumor associated epithelial cells 948 581 355 PMC7460823__F1 Representation of the metabolites and related pathways involved in the Epithelial-Mesenchymal transition (EMT) process in cancer 790 7099 83551 134860 2865 2867 6615 4087 4318 9113 55902 10413 999 PMC7461042__F2 HIF1 signalling pathway 3569 7428 8453 2056 7018 7037 1950 2597 226 3939 PMC7461872__F3 Fve-type FIPs on the immune system, adapted from Hsu et al 941 942 9308 324 6714 PMC7464415__F11 TLR3-dependent activation of MyD88 signaling: TLR3 activation triggers endogenous ligands of TLR2 (HMGB1 and Hsp60) via the usage of the MyD88 signaling pathway 7097 10333 3146 3606 7124 PMC7464784__F1 An illustration of glucose metabolism leading from the glycolytic pathway to the tricarboxylic acid cycle (TCA) and electron transport chain (ETC) 5209 2147 5212 2597 3939 545 PMC7464784__F2 Illustrating the metabolic components contributing to drug resistance and drugs to overcome the resistance 11040 3099 3939 5209 4615 7099 2019 2475 3693 3091 3945 1956 3297 2264 10818 PMC7466665__F3 Role of LPA on Hippo-YAP mediated osteogenesis, angiogenesis and osteoimmunology 4018 284 4283 860 942 3603 383 4485 60485 9113 PMC7468876__F2 Schematic representation in IPA of the ILK signalling pathway 5728 8440 253260 5829 7016 85451 836 2475 4666 3725 51176 7431 999 3875 650 1832 4318 4513 PMC7469280__F3 TRAF6 regulates tumor related to signaling transduction pathways 958 51295 7189 4318 1499 4041 PMC7470069__F5 Mercury-sulfhydryl-dependent effects on apoptosis regulation 9817 5728 367 596 PMC7471874__F11 Expression patterns of genes in IL-1 Signaling Pathway upon EI24 silencing 4615 54472 51295 7189 23118 10454 PMC7472693__F3 Coordinated regulation of the host NFKB pathway by L 7189 7334 7336 81858 10454 PMC7472745__F1 Replication cycle of HIV: graphical depiction of the major events of the HIV replication cycle 1234 920 7852 PMC7472989__F1 Classical neuroimmune network 2638 3553 3458 PMC7473788__F4 Working model proposing how TFAP2C and TEAD4 promote formation of the apical domain, which in turn, negatively regulate LATS1/2 activity in the outside polar cells 387 84612 9113 26524 7004 7022 6093 9475 PMC7473788__F5 Working model proposing how TFAP2C functions downstream of the Hippo signaling pathway to regulate Cdx2 expression in the outside polar cells 154796 9113 26524 4771 10413 7022 1045 6657 7004 PMC7476086__F8 Proposed schematic model: CRISPR/Cas9-mediated knockout of SHP2 inhibits breast cancer proliferation by regulating Cyclin D1 stability via the PI3K/AKT/GSK3B signaling pathway 2885 2549 595 PMC7479481__F2 Major signalling pathways of DNA sensors 115004 170506 1660 9447 3428 23586 4615 6778 3661 3665 7124 PMC7484123__F1 Metabolism of hydrogen sulfide 875 58472 23474 1491 6821 4357 847 7263 PMC7484684__F5 DE miRNA/mRNA interaction network constructed and visualized using Cytoscape software 27235 121665 11074 4642 121536 4092 5579 6581 5467 337878 145282 654429 4040 118 84138 5578 6422 57497 9672 57823 28996 29966 30815 221184 1080 64080 9683 1955 26115 90990 64744 1116 9848 57403 PMC7485387__F1 FGF23 regulation in osteocytes 3553 7099 4615 5741 5745 7189 2260 2247 6774 8074 7421 4703 759 2308 84876 238 3480 5251 1758 1958 PMC7487321__F3 Oxygen-dependent pathway of plasmalogens biosynthesis in animals 5091 355 55711 84188 PMC7488244__F1 Melatonin and urological cancers: a new therapeutic approach 8772 23411 367 PMC7488343__F7 Obesity, ER stress, miRNAs and endothelial function 22926 7494 468 PMC7488620__F7 Parental RHC reverses ischemia-induced changes in rod phototransduction pathway proteins 6010 5158 3000 5132 2986 8787 2979 2782 6295 1259 407 5957 2780 2983 5566 2793 5147 5567 2784 5146 2982 611 2779 10681 PMC7491749__F4 Overcoming Resistance to Drugs Targeting KRASG12C Mutation 3845 6654 3265 6790 3845 6654 3265 6790 PMC7491749__F1 Ras Signaling Pathway 2549 2885 6654 PMC7492232__F1 Proposed mechanisms of sex-related susceptibility to COVID-19 59272 7113 1636 PMC7492298__F6 Granulosa cells undergoing apoptosis 2492 841 8772 356 355 637 842 836 581 10018 PMC7493015__F7 Epithelial repair mediated by LXA4 in bronchial epithelium 5032 2358 24145 PMC7497261__F1 Different inflammasome complexes: (From left to right) Engagement of different TLR receptors leads to activation of IKKs, which in turn results in activation of NF‐KB signaling 22861 58484 9447 114548 387 5586 5585 91039 3146 79792 140609 PMC7498629__F2 Role of FoxO signaling in activating ubiquitin-proteolysis and autophagy-lysosomal pathway when skeletal muscle is immobilized 3479 23411 8408 2475 9927 79594 51024 PMC7500866__F1 Somatic Liver Knockout (SLiK): A quick and efficient way of generating liver-specific knockout mice using multiplex CRISPR/Cas9 gene editing 9748 3242 3081 2184 84842 PMC7504796__F1 Role of the glutamate oxaloacetate transaminases: 3-mercaptopyruvate sulfurtransferase (CAT:MST) axis in promoting and sustaining cancer 3845 27349 9817 PMC7504796__F3 Interdependence of CAT:MST axis, glutathione (GSH) bioavailability and cysteine metabolism 847 2936 875 PMC7506139__F3 BCAAs and fatty acids regulating inflammatory signals 355 3553 114548 PMC7506147__F1 In the cytoplasm, PTEN mediates dephosphorylation of PIP3 to PIP 2 which inhibits the PI3k/Akt/mTOR signaling pathway leading to slower tumor growth 5728 2475 3845 405 648 PMC7506548__F1 Activation and regulation of canonical NFKB pathway 7099 8717 114609 7186 7188 4615 10892 8915 7189 23118 257397 51135 3654 7098 8772 PMC7507442__F1 DNA damage and the programmed cell death pathway (apoptosis) induced by radiotherapy 6741 8772 5810 4361 472 545 4193 581 596 PMC7510303__F4 Diseases and regulator effects networks associated with the differentially expressed peptide precursors 8671 27161 8927 58508 1286 6786 8997 9696 23345 7067 57448 11221 23224 2034 7249 79026 84818 57822 11280 3714 10297 5284 4548 53353 56848 5241 4651 283463 22915 7112 57597 63891 1822 6645 136259 PMC7515827__F2 Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications 2752 3417 3418 440 1806 2271 47 6935 7291 1000 999 4837 1956 2166 3156 PMC7515865__F1 PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers 613 5728 5163 7249 7248 6009 PMC7515907__F3 Interconnections between cilia, aging and Alzheimer’s disease genes 3643 581 7018 4846 6648 1965 1718 7167 23621 274 4852 3416 596 578 4792 7158 348 7124 27429 836 1956 55036 28981 9525 9742 583 2885 127602 137492 83861 1813 1915 642 55212 5621 10131 55567 10015 55172 585 5170 2353 7015 3725 367 5310 1191 3630 6990 26146 2185 1869 7157 22976 9576 5747 5367 25776 7422 55081 1018 7251 57096 2623 2033 2908 5664 140805 3337 2847 5663 8900 83657 5500 5925 6117 6464 4867 129880 7013 10273 3717 3303 90410 5465 84229 5727 5578 2 672 5580 5468 983 51364 5328 6674 2547 56171 5888 253260 200894 4036 4193 801 2023 6517 2932 3162 3603 PMC7518341__F1 Angiotensin-converting enzyme 2 (ACE2) causes the production of angiotensin (1-7) Ang-(1-7) from angiotensin-2 (AngII) 59272 545 627 581 29949 PMC7520643__F1 Protein kinase B signaling pathway 5728 5163 1728 PMC7523401__F8 Target-Pathway network for HQ-BS anti-IBD 7157 7422 6347 3383 3717 595 3606 4318 1956 842 6401 5578 3627 6774 2335 2353 3479 3586 2475 836 5743 7412 3605 3576 3596 3725 4846 6772 3162 3458 367 207 3643 7040 3320 7097 999 3553 5468 7099 7124 3569 5970 2099 113 PMC7528506__F1 Homologues recombinant DNA repair system 4361 5888 79728 672 472 675 3014 9025 10111 27005 PMC7528617__F6 Analysis of HIF-1 signaling pathway 6774 7428 8453 2056 1977 7012 759 5163 2597 2023 PMC7533892__F3 Consequences of IDH1/2-related cancer metabolism for redox homeostasis 4190 3417 50507 4199 23530 718 23410 3418 4200 PMC7535138__F2 Intracellular signal transduction of adipokines and insulin resistance 3953 3667 9021 6774 PMC7536388__F7 Interrelations between profibrotic Smad2/3-dependent and anti-fibrotic Smad1/5/(8)9-dependent pathways in HBFs 655 4087 4090 4088 4086 4089 2638 353128 450086 PMC7536827__F2 Proteins associated with neurotoxicity and neurodegeneration 51596 2475 1356 PMC7538629__F5 Changes of FAs metabolism in hamster liver of HFD group (A) and HFD+ADT group (B) 948 355 3992 9415 55669 PMC7538683__F5 Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer 4089 6502 4199 5111 1022 1017 4661 472 545 637 10572 9615 7249 5728 5555 PMC7541492__F2 Tumor microenvironment (TME) contributes to resistance via EMT 8205 729230 6347 4318 6935 11201 1956 PMC7542236__F1 PI3K/Akt/mTORC1 pathway, Ras/Raf/MEK/ERK pathway, mTORC2 signaling, and the EMT process 1445 6714 3667 6850 387 6009 9776 1977 PMC7544743__F1 MAL structure, pathway and dependent immune responses during infections 7097 54106 7189 4615 8835 3654 8651 695 4118 4049 3656 51135 8195 10454 23118 257397 PMC7545119__F1 Diagram of substrate utilization and suspected pathways in BAT 948 4023 84803 2194 51660 25874 10555 84649 7350 9673 64849 PMC7546399__F9 Network diagram of the metabolic pathways regulated by XFZYD on d 3 and 21 383 4842 2555 2571 2572 PMC7552005__F1 PKR at the crossroads of virus sensing, innate immune signaling, and stress response pathways 83939 57506 468 29110 331 3661 7188 7187 7186 7189 PMC7552065__F2 HBV infection pathway 619511 3972 6461 PMC7554194__F3 Schwann cells integrate signals from the extracellular matrix (ECM) including mechanical forces, laminins and collagens 10413 7003 2778 3655 1605 5376 1959 PMC7555059__F4 Proposed antagonistic relationship of 53BP1 and BRCA1 during DSB repair pathway choice based on DNA resection 3014 672 55183 472 PMC7558374__F2 Known functions of FMDV structural proteins on immune escape 3458 3716 5094 3921 7187 10379 10010 7186 6772 29110 6773 3661 PMC7563227__F2 Roles of PGs in hormone-dependent cancer metastasis 1431 6774 6364 6714 3579 6382 4040 PMC7563523__F1 Proteins, non-coding RNAs, and signaling pathway regulators involved in the lack of response of colorectal adenocarcinoma to pharmacological treatment 7298 6573 1956 2064 540 652995 7422 5281 1544 960 999 8549 1577 1576 8824 2938 378938 1499 6657 9446 961 79923 7291 9839 324 1977 6615 581 572 637 8772 2067 7508 4350 3845 PMC7564398__F1 A high-fat diet (HFD) and chronic cannabidiol (CBD) administration on the sphingolipid metabolic pathway in rat myocytes 10558 56848 427 1674 7357 PMC7564652__F3 AD pathway with target genes of upregulated miRNAs highlighted 65057 351 174 2242 57142 23385 3416 4023 8772 842 836 317 6622 7186 28 324 203068 574 3630 PMC7564652__F4 AD pathway with target genes of downregulated miRNAs highlighted 351 174 23385 3416 4023 3952 572 8772 28 6622 545 7186 7971 324 203068 3569 7124 2475 3630 3643 PMC7568356__F3 CircRNA-miRNA-mRNA networks in hematological malignancies 1499 7976 693192 595 331 PMC7570055__F2 Cigarette smoke-related vascular irritation and activation in patients with COPD 2833 4283 3627 4050 2920 729230 3553 3066 7039 PMC7572606__F1 MYC transcriptionally upregulates the glutamine metabolism pathway 8737 4609 10537 2936 10055 4615 6612 10401 3418 27074 2091 4792 6773 5329 4940 64761 56829 103 9961 7812 31 6667 3099 25987 10528 6599 2002 10054 7031 466 10628 790 5721 3133 10384 25939 7706 684 3872 11054 2475 2000 471 6241 1468 8402 2744 6472 10606 4830 158 5198 51629 PMC7576599__F1 Emerging role of the Hippo pathway in autophagy 8408 60673 9776 22863 64422 55054 26100 9140 PMC7581496__F8 FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential 8817 2263 2885 6010 4485 998 9113 26524 10413 4609 PMC7582305__F6 Downstream signaling cascade activated by ATR and ATM via CHK1/2 dependent phosphorylation events 4193 7157 581 PMC7583949__F2 Macrophages in cardiac fibrosis 3586 6351 929 7124 3084 PMC7584566__F5 Schemes depicting hormonal axes involving insulin-producing cells (IPCs) in adult flies 324 9575 64146 PMC7589579__F2 Schematic representation of the endogenous and microbiota-associated pathways engaged in tryptophan breakdown in the gut environment 196 29 3620 920 PMC7589708__F2 Wnt non-canonical signalling pathways 4920 23002 6010 PMC7593574__F2 Dab2 modulates inflammatory pathways in macrophages and dendritic cells 7099 4615 7189 1601 3661 3458 1436 1435 6714 3717 3569 941 942 PMC7594023__F1 Pathway analysis map showing VEGF signaling via VEGFR-2 generic cascades 7422 4690 6714 2885 6461 3265 387 6093 998 847 5879 5595 5594 9261 1499 5328 6925 3725 5743 5329 1385 4512 6347 PMC7601316__F1 Tumor necrosis factorA (TNFA) downstream signaling pathway mediated by two TNFA receptors, TNFR1 and TNFR2, and by membrane form of TNFA (mTNFA) reverse signaling 1636 8717 7186 7187 PMC7601870__F2 Crosstalk between CK2 and signaling pathways (A) regulating fatty acid synthesis or (B) controlled by phospholipases 6667 47 2194 7391 3949 6319 5338 382 5163 7249 6009 PMC7603197__F1 Aberrant FGF/FGFR signaling in breast cancer 3535 10818 2885 867 2549 351 PMC7603200__F2 MTOR pathway 5728 64798 51256 6009 331 1977 10797 790 2932 PMC7603200__F4 Connection between the PI3K/AKT/mTOR pathway and GLI activity 5728 2736 2735 6009 64798 2737 2932 PMC7603366__F2 Dysregulated DNA damage response genes involved in pro-proliferative and apoptosis resistance characteristics of PAH-PAECs 440275 659 51366 23300 672 472 5888 5053 PMC7606466__F6 RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGFB) signaling 1601 10131 351 3985 6093 11059 5601 5894 51377 3690 6464 6654 3691 6711 8462 5747 5371 207 4087 2335 11171 10413 595 4089 4739 3065 5576 1026 6935 22938 4208 9839 7049 2113 857 PMC7609165__F1 Host-Pathogen Dialogues in Autophagy, Apoptosis, and Necrosis during Mycobacterial Infection 7099 26253 4615 115004 10626 80712 345611 55054 2475 5465 7942 PMC7611290__F3 REV7: Jack of many trades 5425 991 999 324 983 2146 112441434 54537 5901 8202 6925 338340 5546 2002 1211 7001 6493 PMC7642035__F6 Therapeutic Interaction of WNT Pathway Activation and Asparaginase 324 1499 847 PMC7643412__F1 Ferroptosis pathways 8314 9817 2937 1803 3156 3652 2879 8031 3315 2182 10162 2643 PMC7643412__F3 Published molecular mechanisms of ferroptosis in breast cancer 8737 92140 11035 83939 197259 468 79094 2937 6774 2879 6714 2643 23657 PMC7643412__F4 Crosstalk between ferroptosis and apoptosis, necroptosis, autophagy-dependent cell death and pyroptosis 79094 2879 6382 8737 11035 197259 581 317 23657 PMC7661711__F2 PTRH2: an adhesion regulated molecular switch at the nexus of life, death, and differentiation 51651 5310 581 6194 2475 596 7088 999 PMC7662147__F2 Life cycle and cleavage of SARS-CoV-2 and ENaC in airway cells 7113 59272 5045 10487 PMC7663135__F3 Endo-lysosomal system is a complex pathway that is vital to countless processes in the cell, and its dysfunction results in the hallmarks of many diseases 8411 6098 55054 7942 759 PMC7665128__F2 Calcium homeostasis and signaling in healthy neurons 84876 6786 4827 90550 PMC7669705__F2 Opportunities for combination therapy 6790 5347 891 983 5728 595 1019 2475 5925 4763 PMC7682536__F1 Spectrum of RAS-MAPK pathway disease genes and associated RASopathies 6016 6237 3265 1431 867 3845 2885 8216 5894 673 22808 8036 161742 PMC7683115__F6 lncRNA-miRNA regulation mechanism diagram based on the insulin signaling pathway 440823 55384 101927058 3630 3643 PMC7689098__F2 KLF13 regulates cAMP signaling pathway genes in HT22 cells 7074 5058 7410 64411 387 5906 5894 268 808 2353 3725 6010 627 PMC7696406__F8a 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells 1610 6722 7124 8717 355 4149 4208 929 23118 51295 PMC7697003__F4 FAK involvement in rhabdomyosarcoma 3479 3082 6714 7249 2475 PMC7697192__F2 Kin regulates macrophage polarization through MAPK, NFKB, and STAT6 signaling pathways 22944 6778 383 3586 3569 3553 PMC7700122__F2 Under normal homeostatic conditions, Keap1 homodimerizes through the N-terminal BTB domain and binds to the cullin-based (Cul3) E3 ligase, forming Keap1-Cul3-RBX1 (Ring box protein-1) E3 ligase complex, leading to Nrf2 ubiquitination and degradation 9978 8452 9817 2730 1728 PMC7704201__F3 Nrf2/Keap1/ARE pathway in T2DM 2939 9817 8452 4094 PMC7710720__F3 Sortilin and its soluble form (sSortilin) in colorectal cancer 999 717 6714 PMC7710763__F1 Interaction between gut microbiota, immune system and tryptophan metabolism in brain tumor development 23657 3558 468 6509 3569 6510 3586 3553 1950 3620 6772 196 405 920 PMC7713510__F6 SRC-1 and SRC-2 serve critical roles in developmental regulation of 11Beta-HSD1 expression by glucocorticoids and cytokines 2638 7124 3553 PMC7714562__F3 Overall depiction of the TRAF6-mediated signaling pathways 7189 10892 6714 51311 54106 51284 7099 7098 867 7187 51135 4615 23118 257397 10454 3665 PMC7714932__F4 Vascular diseases: the roles of miR-21/miR-21-3p in ECs and VSMCs 7168 5728 27250 151 6667 388 5465 PMC7715033__F1 Immune and molecular mechanisms of FSGS pathogenesis 958 23529 729230 941 PMC7719714__F1 Cellular response to stress via O-GlcNAc-dependent epigenetic regulation 8473 10724 80012 10155 3014 2146 10873 PMC7719714__F2 O-GlcNAcylation induces the DNA damage response and proliferation in stem cells 3014 8473 545 472 10724 PMC7721054__F2 Anatomy of an mRNA 1977 1999 1998 PMC7724080__F2 Resistance to poly (ADP-ribose) polymerase inhibitors (PARPi) 8505 672 149840 54537 112441434 55183 472 545 10111 4361 9156 80198 91607 79728 675 PMC7724827__F2 Interplay between EVA71 infection and autophagy 55014 60489 23192 9342 8408 8678 4615 3665 5371 PMC7730145__F3 Novel strategy to facilitate neuronal Cl− extrusion and EGABA by coincident NKCC1 inhibition and KCC2 activation by inhibiting the WNK-SPAK/OSR1 kinases 130497 1152 65125 65267 PMC7730327__F2 TAp63A acts as the central integrator for DNA damage signaling in oocytes 472 545 581 PMC7736222__F2 PGC-to-ProSG-to-SG transition 5225 8433 29947 143689 1029 1618 1617 9844 23022 983 4288 2119 2118 3732 3975 3815 346673 2674 3400 342977 5916 5460 PMC7738628__F5 Selected P5 and/or P10 enriched pathways 355 11221 5608 4137 3316 3315 1270 1649 6722 3162 793 7132 4615 2555 2561 974 6850 5777 695 958 4773 627 29108 942 2932 2560 3635 2752 3725 2557 2904 5322 2563 4345 2890 5321 4908 5287 2902 5295 5578 2475 468 93 2566 2353 3105 1326 4293 1958 PMC7738893__F1 Action of monoclonal antibodies (mAb) in cancer therapy 7422 324 998 8772 942 7535 6714 1493 6774 581 2475 6850 PMC7739442__F1 Inborn errors of immunity conferring predisposition to childhood HSE 29110 3661 51163 7098 7187 6772 7297 3716 6773 10379 PMC7754529__F3 Co-expression pattern of the most significantly enriched pathways of differentially expressed genes involved in post-traumatic stress disorder 4137 1326 4915 23542 80824 1850 1849 57551 6788 1147 23118 22808 3643 84867 8517 5321 2257 4790 5578 3845 1950 5228 816 1956 5868 5894 2904 1399 7039 5781 83593 51764 5290 2549 29110 6654 PMC7755097__F3 Retinoic acid signaling pathway is identified by topographic transcriptomic analysis of NAcSh 5199 1284 1053 923 1280 440 7529 7494 4904 10844 7013 7043 6484 1452 23473 947 7832 3983 526 7337 25890 64220 10166 8804 1499 2885 2912 10752 3098 3866 359787 55683 3299 3912 5606 116372 5173 56603 2171 1662 7323 6853 6256 2572 9636 3216 2624 3280 8939 1811 7477 81619 27250 6909 5358 5054 5583 6125 92799 9985 55209 1381 5467 5027 5803 6647 5916 59269 5914 5621 22822 5526 11156 23095 3512 5599 1382 3956 10076 4831 4170 63974 4208 4316 4056 4259 5496 4723 4775 89797 PMC7755516__F1 Intestinal epithelial cells (IECs) apoptosis in an acute and chronic state of intestinal diseases 7186 8717 8737 7188 8772 4790 PMC7757038__F1 Exosome biogenesis and composition 382 5873 5874 10743 11021 967 928 975 3732 7251 4553 PMC7757040__F2 Diagrammatic illustration of the mechanism by H2S donors in regulating autophagy and cell migration 9474 6667 2475 1499 3984 7078 999 1000 PMC7757125__F9 Metabolic pathways connecting gene expression, DNA methylation, and targeted metabolomic data 51660 25874 5164 5166 31 1738 32 55902 5132 23417 2194 1431 847 PMC7758035__F5 GA biosynthesis and inactivation, highlighting the GA signal transduction pathway that enables GA homeostasis 7175 7018 2077 PMC7758290__F1 Complement system 716 717 1378 1604 2271 4179 727 966 1191 PMC7760721__F2 AB peptides are derived from the processing of the BAPP (APP) through the amyloidogenic pathway 255022 367 771 7494 468 PMC7761714__F2 The NRF2 signaling pathway by microRNAs (miRNAs) in cancers 8452 693186 693202 3066 84293 571 23411 2936 2729 4094 9817 PMC7762844__F1 mTOR signalling in the cell at a glance 7248 7249 6009 64798 6446 PMC7764163__F2 Simplified canonical NFKB signaling pathway with its many deubiquitinating regulators and the molecular targets of those enzymes 8737 8717 23118 257397 7186 1540 55611 5971 PMC7765110__F9 The proposed pathways by which melatonin regulates testosterone production and protects the testicular tissue from oxidative damage in LPS-induced sheep orchitis 6770 7536 7099 3553 2643 847 PMC7766764__F4 Regulatory network for fungal dimorphism in U 5879 1020 56954 5469 5551 10518 6098 10519 10978 PMC7767220__F4 Roles of MMPs and TIMPs in the pathogenesis of human inflammatory diseases 3553 2475 4312 7077 7078 PMC7767423__F1 Fatty acid mobilization and utilization in skeletal muscle during endurance exercise 4099 1376 3717 4023 PMC7770202__F8 Response to aging in the mouse somatosensory nervous system 627 4852 467 796 10267 6863 5970 4790 8989 PMC7772566__F6 Mapping germ-layer specification preventing genes in hPSCs via genome-scale CRISPR screening 51686 23198 5709 6169 6235 6182 5698 1329 51588 29796 8841 7311 7386 1350 5409 4702 2033 2167 8310 3422 2224 4705 54511 349565 1149 9370 6667 6307 51703 5468 39 50814 8875 6319 51109 10157 10135 683 51170 384 29968 284541 79923 6657 4524 10840 160428 47 3157 4598 6713 55012 4597 4047 1717 6720 PMC7773602__F1 Autophagy and endolysosomal trafficking at the synapse 11021 25837 351 PMC7775273__F5 Mechanical Regulation of Apoptosis in the Cardiovascular System 8717 8772 843 841 637 842 836 840 PMC7775514__F1 Toll-like receptor 4 (TLR4) signaling in Alzheimer disease (AD) 3146 54209 929 948 7099 348 5336 998 114609 4615 7189 29110 3661 PMC7775721__F1 Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease 2720 3073 3074 2629 427 410 2581 4864 10577 6609 PMC7779655__F1 Cellular copper homeostasis in mammals 540 9973 6647 538 475 90639 1353 9997 10063 388753 116228 493753 5250 6649 1621 84695 4016 84171 4017 5066 4015 1356 PMC7779655__F4 Copper-dependent mechanisms of oncogenic signaling 2475 8408 9706 PMC7779655__F5 Copper-dependent mechanisms of cancer cell migration and metastasis 595 475 4015 538 51072 6714 PMC7780046__F5 Enhancement of epithelial‐to‐mesenchymal transition (EMT) via the loss of N‐myc downstream‐regulated gene 2 (NDRG2) activity 4087 4088 57447 4089 999 1000 PMC7780227__F1 MAPK pathway: activators and inhibitors 998 6010 6722 1386 PMC7783313__F5 Macrophage and bone remodeling related diseases 8205 11035 6362 PMC7784358__F5 KEGG pathway enrichment analysis and pathway map for RA 6347 6348 6364 8178 1493 4050 9317 3569 1514 5741 1513 100187907 PMC7786386__F4 p38-signaling in white adipose tissue browning 2638 10454 1386 10891 7350 PMC7786975__F1 Metabolic characteristics of M1/M [LPS(±IFNG)] macrophages 5209 2147 47 50 435 5979 3091 PMC7786975__F2 Metabolic characteristics of M2/M [IL-4/IL-10] macrophages 948 5207 2147 383 2744 PMC7790578__F9 KEGG pathway details identified by FB against COPD 472 545 355 7465 10763 581 637 4067 2582 8772 8178 847 3717 PMC7791126__F3 The TGFBeta-induced canonical SMAD and noncanonical signaling pathways 4087 2885 4088 6010 7189 9618 4092 4089 2475 355 90427 50943 3589 4318 4313 993 3397 1869 596 2625 3458 100507436 PMC7793096__F3 Carbon monoxide-induced phenotypic switch of macrophages 3586 941 942 PMC7801270__F1 Melatonin signaling pathway in the occurrence and development of OA 3606 23411 10135 10725 PMC7802216__F5 Roles of palmitoylation during structural LTP 1000 9463 998 5879 3984 387 PMC7803009__F1 Congenital Malformations in Pregnancies with Pre-existing Diabetes 1789 5077 2539 PMC7809420__F5 Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration 102 27283 10423 11117 10627 637 55714 10855 266710 4060 5802 978 5082 1535 847 79784 4803 114826 2263 55741 2817 5066 1948 7408 7431 388 1962 581 7361 64066 7052 6418 1105 23143 9227 2669 2938 85004 3725 4323 222484 64781 8972 5997 2717 57817 643988 3929 80790 203068 374569 9510 4118 345079 367 10544 9464 PMC7809767__F3 AURKA interactome and related signaling pathways 4193 4089 6790 23510 5898 7756 1499 3985 5789 10460 55835 26524 4771 84962 5578 1058 10492 4792 10018 2551 2553 3551 2932 PMC7810546__F7 Compound-target-pathway network 4314 4353 2155 2053 653361 4843 3357 367 7153 4973 759 57007 7015 5590 596 2147 6401 5468 2752 5139 7415 5743 6714 7421 6850 4321 2100 217 673 4846 5582 5581 581 3791 3725 7124 3815 2247 5530 9641 249 4137 5580 4638 351 816 2033 2149 7086 3717 4193 5583 2833 PMC7811960__F2 Azithromycin effects in the pathophysiology of COVID-19 after receptor-mediated endocytosis, both viral (PAMP) and host released (DAMP) molecules trigger antiviral pathways 7018 59272 1636 3553 3558 3569 3627 11201 3458 3586 324 920 3565 PMC7816800__F5 Functional interactions between genes under positive selection in the SIRT signaling pathway (ingenuity pathway analysis, IPA) 5914 7486 5970 PMC7819563__F3 Correlation between glucose metabolism and amino acid metabolism in tumor cells 2539 26227 3939 3417 2746 84706 100653366 445 PMC7820759__F4 Schematic view of the molecular network and functions of human papillomavirus (HPV) E5, E6, and E7 oncoproteins in HPV-induced cancers 1956 8473 999 9368 6774 10498 3276 23135 7403 8453 1017 1786 3133 1876 993 1021 1874 1019 2305 1869 PMC7821690__F1 Crosstalk Signaling and miRNA Deregulation in Obesity Related Breast Cancer 6714 3717 406991 5728 8091 4193 2308 572 2353 6774 PMC7821787__F1 MTOR signaling pathway and Rapalog therapeutic mechanisms 5728 7249 7248 6009 2475 64798 253260 PMC7822116__F3 Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects? 6647 2876 23410 5444 PMC7823450__F2 Novel regulatory pathway of oxysterol sulfation 1593 572 1786 PMC7825147__F1 Transforming growth factor B (TGFB) signaling pathway 4092 4088 387 4087 4089 2475 85451 7018 PMC7826375__F6 The interplay between ATRX and RECQ5 to regulate distinct subpathways of HR 546 5111 80198 641 348654 PMC7826734__F1 Role of VEGF signaling in OSCC 6351 1950 6774 PMC7827874__F2 Transforming growth factorB (TGFB) superfamily signaling in PAH 4838 7048 4090 4086 998 387 182 3397 PMC7828172__F2 ROR1 signaling 4919 81029 7474 51384 6714 5478 1794 6774 23002 998 55083 387 2475 5970 3725 6194 2353 595 891 898 1019 598 596 836 6935 6615 7431 648 5243 PMC7828172__F3 ROR2 signaling 4920 81029 7481 7474 5478 6714 6774 23002 998 55083 5163 387 2475 3725 6194 2353 5111 894 983 4318 4322 4313 6591 7431 6935 PMC7830660__F1 Immune evasion by NSVs 57762 9961 51311 7098 51284 3569 4615 6773 6772 3665 3661 3716 920 PMC7830946__F7 Nuclear factor erythroid 2 (NEF2)-related factor 2 (Nrf2) signaling pathway of oxidative stress 847 9817 8452 PMC7831311__F7 Important pathways affected by long-term 1-MCP treatment 50 1431 47 1738 4190 4397 790 1312 PMC7832464__F2 Progression of SARS-CoV-2 infection and inflammation 59272 6868 3553 2219 PMC7838386__F3 Extracellular factors govern dendritic morphogenesis via convergent signaling 3950 4087 7249 7248 6009 PMC7842149__F1 Roles of the RAAS in health and COVID-19: A better and worse scenarios—(A) Basal angiotensin system 1636 59272 10750 7113 6868 PMC7842189__F2 Microglia-Tissue Consensus Module Microglia Disease Time Course and Pathway Annotation 54623 4851 4242 10563 929 1522 1075 51429 1025 5880 4689 8530 397 391 5054 3687 79365 5900 23175 5663 975 122618 1051 5329 6237 10507 207 8651 5371 79132 3557 3635 7297 4791 23550 5863 2268 567 382 1796 57506 861 5720 834 5155 6773 5788 933 5133 5216 23433 9672 7408 125950 3693 60 29126 5768 10148 3455 7305 998 840 5725 5585 9181 7178 3936 50619 51177 2207 11006 54209 950 7096 7097 64135 54106 51284 PMC7842273__F1 Two major arginine metabolic pathways: NO synthesis vs 435 5009 2643 383 384 262 PMC7846573__F7 FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability 2177 59286 55215 468 PMC7848346__F1 Traditional (right hand side, orange background) and alternative (left hand side, blue background) renin‐angiotensin‐aldosterone system pathway 59272 1636 1611 PMC7851083__F1 Important events during research development of macropinocytosis in cancers 5064 387 998 100187761 PMC7851083__F3 Mechanism of extracellular proteins internalization through macropinocytosis 1956 5728 468 4553 5879 PMC7853511__F8 Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities 7442 324 4922 PMC7854502__F5 Developmental pathways in liver cancer 3516 3481 6696 6662 1499 3549 81788 2752 5465 PMC7858151__F8 MAPs alleviates AFB1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers 9817 581 847 PMC7859603__F1 DisGeNET contains a list of diseases associated genes that have been collected based on the presence of genetic overlaps between diseases 4314 3562 6347 7045 929 355 3586 3569 3558 5970 3725 7421 596 6909 6774 7124 1051 7038 1956 3458 3135 5468 3559 338 3605 4602 6401 4843 3122 5243 4261 324 114548 PMC7865483__F7 Key players of the CoA biosynthetic pathway in bacteria, yeast and mammals 79717 60490 2247 80347 PMC7867637__F2 High glucose on fibroblast activity and function 3553 1490 6678 PMC7868824__F45 Targeting NFKB mediated cell signaling pathway and inflammatory mediators by 1,2-diazole in A549 cells in vitro 999 1956 7099 PMC7868824__F8 Overall, pyrazole significantly up-regulate E-cadherin expression and regulated MMP-2 expression in A549 cells 999 1956 7099 PMC7869230__F9 IL-17 signaling pathway cascades obtained from the global proteome data by KEGG pathway analysis 8178 8717 8772 66037 23118 6354 6347 4513 7124 84818 7189 7186 4314 4318 9618 29761 920 132014 55540 100187907 53342 960 PMC7876257__F1 Figure summarizes the potential diet—epigenetic axis in T1DM development 6416 2865 2867 PMC7880238__F1 Key signals regulating YAP/TAZ activity 6714 6010 9113 26524 4771 154796 7003 8463 7004 7005 4485 9344 51347 57551 8491 11183 9448 11184 5871 PMC7882000__F1 De novo synthesis and regulation of cholesterol 38 1718 1717 1581 PMC7882032__F4 Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity 7248 7249 27244 83667 472 545 4193 PMC7882887__F4 Emerging role of estrogen related receptorA in complications of non-small cell lung cancers 7249 7248 2475 7472 PMC7884719__F1 BDNF and MAP kinase pathways in combined portrait of depression 627 2669 3241 10251 5997 10252 81848 2257 7832 1960 10253 200734 1959 7837 9592 5578 161742 390 1843 1846 9732 6194 9456 1844 2354 4771 23237 467 650 3726 28951 3775 3707 3479 9314 7043 6876 7422 2932 324 5027 1316 3488 5257 1942 284 3880 5771 776 5999 3315 10628 8543 9846 871 10771 4926 54206 3337 5937 2317 3673 PMC7886986__F1 Major immune cell checkpoints and associated signaling pathways 324 962 151888 3902 7535 940 941 942 7186 7189 7188 PMC7889583__F1 Multiple MDSC-mediated immunosuppressive mechanisms 3603 4615 4609 595 1536 383 7939 4318 4513 6868 324 6774 6778 6772 PMC7892237__F3 Autophagy: binding of growth factors to its receptor (tyrosine kinase) gets activated leads to the activation of PIP3K which phosphorylates PIP2 to PIP3 and recruits protein kinases PDK1 and AKT to inactivate TSC and RHEB 7249 7248 664 5371 2475 7942 PMC7892973__F2 Role of irisin-involved integrin signaling cascade in modulating tumor microenvironment remodeling 252995 975 4615 6774 7189 387 2475 7099 PMC7895570__F1 Lipid metabolism of cancer 4023 355 47 PMC7897327__F2 m6A RNA modification regulates hematopoietic system development 56339 51441 8313 595 5728 596 57506 83939 PMC7900639__F2 Drug induced ER stress response regulation in trypanosomes: (a) Elevated expression of Sirtuins in ER stress might activate autophagy by deacetylating ATG proteins, and sirtuins regulate subsequent switch to apoptosis at a higher stress level 22926 83939 10533 9474 51569 79876 PMC7902034__F3 Activation of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of IFN genes (STING) signaling pathway and AIM2/IFI16 inflammasome 6573 115004 3428 9447 3661 6786 79792 3553 PMC7906923__F1 Molecular signaling pathways implicated in neuroblastoma 1956 238 627 8321 8323 1499 26959 2475 4613 4193 3091 PMC7907026__F2 Diverse roles of the immune checkpoint in tumor cells that drive to the stimulation or inhibition of metastasis 581 6774 7077 3717 619501 2475 4843 961 151888 1956 920 PMC7909764__F3 Senolytic therapies 55074 1019 4193 23476 PMC7909827__F2 Nutrient-secretion coupling in D-cells 6750 51083 847 6263 PMC7911109__F1 Oxidative stress and antioxidants in the context of non-alcoholic fatty liver disease (NAFLD) 7038 468 22926 PMC7911310__F1 Methionine metabolism 6611 6723 4144 262 4397 635 27232 191 875 PMC7912185__F2 Effect of Interventions in WNT Signaling on Healing of Cardiac Injury: A Systematic Review 7038 7480 6422 6423 6424 11197 22943 27123 27122 4040 4041 324 607 1499 PMC7912299__F4 Pathways to the generation of cytosolic and mitochondrial citrate and its utilization 3156 47 23152 2744 50 2271 284111 PMC7912299__F8 Mitochondrial and cytosolic pathways leading to D2-L2 hydroxyglutaric acid (D-L-2HG) accumulation (see text for explanation) 23152 4191 728294 79944 4190 26227 PMC7912342__F1 Toll-like receptor (TLR) dependent signaling pathways 7097 7099 81793 619537 4118 4615 3654 51135 7189 7098 51284 51311 54106 8717 23118 7187 257397 10454 8195 29110 3661 3665 PMC7912475__F2 Impact of Maternal Food Restriction on Heart Proteome in Appropriately Grown and Growth-Restricted Wistar—Rat Offspring 200576 7273 2885 387 1311 2022 25 4638 5605 10097 10109 22800 3611 208 207 59272 185 8862 187 PMC7920740__F3 Description of antioxidant enzyme system regulation via the Keap1-Nrf2-ARE pathway 8452 9817 4094 847 PMC7923226__F2 Main molecular mechanism of actions deployed by the anticancer peptides presented in this review 842 836 581 8772 PMC7924042__F8 Cardioprotective mechanism of catalpol in diabetic cardiomyopathy 581 836 283131 9759 PMC7924042__F9 Cardioprotective mechanism of catalpol in MI 8408 60673 9776 100188776 55626 22863 29982 9140 842 572 836 9474 PMC7924189__F6 Mechanism of rice blast resistance in Tetep at cellular level 4025 7018 2077 4602 PMC7924916__F1 Severe acute respiratory syndrome coronaviruses’ lifecycle and possible mechanisms of interference with p53 and its regulatory pathways 5478 5479 594857 4352 4351 11331 PMC7926305__F5 Molecules associated with the canonical pathway (CP) ERK/MAPK signaling in the function of two stages of oocyte development 1356 6237 5908 PMC7926694__F6 Emerging effect of ferroptosis in malaria immunity 7157 27165 2879 55240 7018 8031 23657 PMC7937358__F3 Immuno-pathogenicity of MERS-CoV 1803 3661 1386 PMC7937875__F7 Canonical pathway analysis 2244 2243 2266 1431 717 183 7412 2 3569 6402 116844 7076 5473 3075 6280 6696 6291 12 6446 2934 9509 567 3339 3507 10894 PMC7938641__F1 Hypothetical concept for the dysregulation of lung epithelial ion and fluid transport by SARS-CoV-2 84890 59341 1080 59272 9368 PMC7944129__F6 Regulatory network of different pathways 2161 2271 718 717 7450 1611 2159 5091 4937 2 1431 727 1380 1361 928 735 23440 4067 10129 4975 PMC7946393__F1 Membrane trafficking regulation of primary cilium assembly in intracellular pathway 4018 200894 11021 83871 10938 30845 11252 29993 9342 51715 27152 22897 145508 3833 146057 80184 54806 91147 22873 26160 90410 79598 PMC7947698__F1 The Wnt signaling pathway in transgenic mice 22943 8205 324 2932 1499 PMC7961726__F2 Representation molecular mechanisms underlying the tumoral properties of glioma cells 1956 356 5728 54487 2353 4255 7157 PMC7968933__F2 Mechanisms through which biological sex could affect BBB integrity 6667 9475 387 1003 7076 301 7077 6010 7412 3383 729230 PMC7969743__F3 Emerging role of ferroptosis in intestinal disease 1803 27035 1026 6303 23657 27165 PMC7969799__F1 The molecular mechanism of TRP channel-mediated pathogenesis of neurological disorders: (A) Alzheimer’s disease, (B) Parkinson’s disease, (C) Huntington’s disease, (D) Amyotrophic lateral sclerosis, and (E) epilepsy 627 2475 54822 7220 7223 7224 59341 57113 5266 8532 7442 PMC7977035__F1 Postlanosterol cholesterol biosynthesis pathway 6309 10682 1674 1718 1717 PMC7982081__F5 Angiocrine factors control liver function 383 8549 8313 7484 84870 7472 654 650 4283 PMC7982480__F1 Neuroprotective effects of ghrelin in PD 3553 581 7351 7471 847 89780 1499 PMC7984428__F2 Simplified canonical model of NMD pathway activation (A) in human cells which is controlled by three different ways so far and yet to be identified (B) 23049 26019 5976 65109 23293 54464 PMC7991912__F2 Pathway overrepresentation and gene ontology analysis of cisplatin-induced significantly deregulated proteins 83442 4553 2000 2194 11224 6128 6139 6208 6159 6137 3921 6129 6224 25873 16 6147 26227 PMC7992789__F3 Roles of miRNAs in modulating the autophagy process in human breast cancer 5728 693223 100422910 100422852 100302284 100302137 100423003 693221 100033819 100302129 100422860 5371 7249 7248 3920 100170220 9776 693196 4077 8878 693152 9140 55054 9474 64422 10533 83734 PMC7996871__F1 Unfolded protein response (UPR) pathways 22926 7186 83939 9817 468 7494 PMC7997455__F1 Error-prone and error-free pathways of DNA double-strand break (DSB) repair 142 672 580 1763 9156 79728 5888 675 7518 PMC7998496__F1 Mode of curcumin actions as anti-cancer agent on the key molecular targets in GBM 4193 581 6469 6608 PMC7998946__F1 Schematic comparison of metabolic pathways between a nontransformed cell and a cancer cell 3099 7216 226 2597 3939 PMC8002044__F2 Adipogenesis and fat deposition and their regulation at the transcriptional and post-transcriptional level in the chicken adipocyte 7038 4023 2624 10365 2170 2167 9370 1718 50814 PMC8006014__F1 Insulin signaling pathways 867 5163 2695 PMC8006014__F2 Pathological effect and consequence of insulin resistance 3643 5728 2885 5140 572 2308 PMC8014161__F11 Network Meta‐Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID‐19 Pathologies 3146 275 1020 5728 3479 6774 85451 27040 PMC8016635__F2 Downstream changes caused by activation of PERK on osteoblastogenesis 4921 860 83939 468 1499 2308 4772 27123 PMC8016706__F2 Growth and stress signalling pathways dictate responsiveness to stimuli and are hijacked in skin malignancy 1950 1896 10913 1956 4609 4513 595 4193 54361 581 596 7078 3280 5970 5971 PMC8021759__F1 Methods to circumvent antiviral immunity 920 10219 3717 999 10379 6773 PMC8024568__F1 IL-10, 13, 17, and 33 interaction mechanism with their specific receptors 90865 7297 3716 6778 4615 6774 7189 PMC8026309__F6 The mechanism through which CTRE inhibits MGO-induced tubular cell inflammation and oxidative stress by upregulating the Nrf2-antioxidant enzyme pathway and downregulating the PKCB/NOX4 signaling 50507 2729 847 1728 2739 7124 3603 PMC8033034__F1 Unfolded protein response (UPR) signaling pathway 83939 7494 468 PMC8033311__F1 Classical necroptosis signaling pathway initiated by the combining of TNF ligand and TNF receptor 1 8717 197259 8772 PMC8034539__F1 B3-adrenergic signaling pathway that promotes thermogenesis in adipocytes 7350 7019 3662 4899 PMC8036323__F5 Cooperation of autophagy with phagocytosis in microglial activation 948 54209 7939 10533 9474 8408 4513 PMC8037155__F2 Leptin signaling pathway 3717 8660 2885 6774 2475 5091 4852 181 PMC8044463__F3 Metabolic genes regulated by Mondo family 3992 4547 9415 10628 91947 7038 8694 84649 2673 9945 5209 3795 2147 80168 2180 7086 2182 79966 60481 79071 355 47 3939 4199 1638 728609 PMC8044766__F1 Thrombotic and thrombolytic cascades and primordial immune response 2 7450 27230 5340 PMC8047580__F3 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy 2475 7098 3091 7189 7018 5340 59272 PMC8050341__F1 Mitochondria and fatty acid metabolism in Tregs 355 50943 47 2171 8011 717 2023 PMC8050341__F3 Lactate and amino acid metabolism in Tregs 159963 2875 948 2805 11113 2744 384 196 50943 PMC8052339__F6 Working model of LPS-induced RAGE signaling in sensory neurons innervating the upper airways 7099 7442 6714 3586 3569 1385 PMC8058408__F5 Pi3K-Akt and IL-17 signaling pathway (A) PI3K-Akt signaling pathway and (B) IL-17 signaling pathway, with key target genes in the yellow box 6955 3416 100187761 1957 81620 2475 1977 51083 5066 5478 613 10752 5728 572 PMC8060181__F1 Osteoblast role in the pathogenesis of rheumatoid arthritis 22943 651 6422 6423 860 650 652 655 9242 PMC8063837__F1 Hedgehog signaling pathway and its possible inhibitions 6608 23432 51684 91653 57758 PMC8064971__F2 Targeting protein-protein interaction interfaces in COVID-19 drug discovery 7113 59272 5045 7113 59272 5045 5478 PMC8065335__F5 Putative mechanisms for CVL218 as a PARP1 inhibitor to combat the COVID-19 disease, derived based on the data present in this study and the known antiviral activities of PARP1 inhibitors previously reported in the literature 142 3569 3553 7124 260431 PMC8065571__F1 Schematics of the eicosanoids synthesis pathway for the production of prostanoids (Prostaglandins—PGs, Prostacyclin and Thromboxanes—TXs), Leukotrienes (LTs) and resolving mediators including D- and E-series resolvins (Rvs), protectins and maresins 4512 4513 4049 4050 5226 5228 PMC8065698__F2 UPR drives pro-inflammatory responses to ER stress 7097 7099 4615 7186 10392 83939 64127 8767 7494 7124 PMC8067192__F4 Network analysis performed using ingenuity pathway analysis (IPA) 89866 5005 4353 319 3250 114900 6289 1628 6291 1191 5950 57136 60 2932 5176 7123 921 8115 26762 3480 2177 3487 10062 6770 3458 6347 169355 PMC8067556__F1 WW domain-containing oxidoreductase (WWOX) interaction partners and signaling pathways in the nervous system 51741 4088 4087 4089 324 1499 PMC8070500__F1 JNK pathway is conserved between mammals and flies 7124 85451 3725 2353 7018 PMC8072315__F1 Major signaling pathways and key mediators of macrophages in acute kidney injury 6774 6778 3718 3717 2056 2475 5163 6850 7099 5728 PMC8072655__F2 Nrf2 in Hearing Loss 8452 2729 1728 PMC8074089__F4 Rho Family GTPases and Rho GEFs in Glucose Homeostasis 5879 5728 5163 3667 2887 PMC8074247__F6 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer 6010 6788 999 260431 545 472 5091 847 324 7927 9314 6769 PMC8074247__F8 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer 545 472 260431 4803 4099 1017 5447 1431 847 5170 56946 27250 PMC8074247__F10 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer 545 472 260431 7852 3479 4803 7939 4397 7015 2821 230 4017 3082 226 2235 4117 PMC8080572__F1 Key signaling molecules in angiogenesis 7422 7423 5281 8828 8829 7424 5159 5155 PMC8081290__F3 Integrated working model of key metabolic signaling axes in macrophages (Mфs) during ischemic organ injury and repair 7099 114548 3553 8011 2475 948 10461 355 11113 952 PMC8081956__F3 Autophagy in Hepatic Steatosis: A Structured Review 8408 60673 9776 22863 64422 10533 9140 83734 9474 9817 PMC8085043__F1 Current Concepts and Advances in Graft-Versus-Host Disease Immunology 3002 355 383 1493 PMC8088111__F6 Signaling pathways involved in the effects of Mg2+ on CLS mediated by the GAAC pathway and Ecl1 family proteins 4553 83939 2147 1632 PMC8089042__F8 Model and Summary: RGS10 regulates pro-inflammatory gene expression through functional interaction with the SOCE machinery 7038 57620 6786 7374 PMC8096065__F1 Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks 142 10038 7515 5111 2067 472 675 5888 7518 353497 PMC8096694__F1 Potential mechanisms by which Nrf2 signaling is regulated via protein interplay as a therapeutic process and in the pathogenesis of heart failure 9817 64122 1410 8452 3717 2534 9870 51548 183 PMC8096694__F2 Epigenetic regulations of Nrf2 signaling by noncoding RNAs in the pathogenesis of heart failure 571 140828 1397 8452 9817 23411 51548 PMC8097256__F1 Human cell receptors: potential drug targets to combat COVID-19 5045 59272 7113 1803 1636 9242 25825 PMC8098721__F1 Canonical and non-canonical Wnt signaling pathways 54894 84133 324 2932 4040 4041 1499 27121 22943 27123 27122 11197 650 595 147111 6010 PMC8100458__F2 Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy 324 1499 998 29 3082 4318 4854 387 PMC8106556__F2 Targeting the alternative bile acid synthetic pathway for metabolic diseases 1582 9420 1593 6718 22937 355 19 64241 64240 1581 8213 PMC8106838__F4 Therapeutic toolkit to modulate Notch signalling 6868 3516 9610 PMC8107079__F9 CircPVT1 up‐regulation attenuates steroid‐induced osteonecrosis of the femoral head through regulating miR‐21‐5p‐mediated Smad7/TGFB signalling pathway 1513 54 1277 581 596 PMC8107841__F6 Investigation of the association between imbalance of the intestinal flora and infantile spasms: a pilot case-control study 340654 387787 1636 PMC8108589__F3 LRP-1 modulates neurodegeneration and neuroregeneration 3603 4803 4035 8717 7185 8772 7186 PMC8112447__F4 Zebrafish Cancer Predisposition Models 7018 867 2885 6654 3265 4763 2475 PMC8112447__F7 Zebrafish Cancer Predisposition Models 2177 55215 11073 545 10293 57697 80233 51455 675 472 84464 22909 2067 672 5888 5889 PMC8117215__F2 Early Emergence of Adaptive Mechanisms Sustaining Ig Production: Application to Antibody Therapy 468 1998 7494 22926 51360 PMC8120183__F7 Cardamonin inhibits the progression of oesophageal cancer by inhibiting the PI3K/AKT signalling pathway 5163 572 581 5164 317 999 1000 PMC8120246__F6 Dissecting the Roles of LncRNAs in the Development of Periventricular White Matter Damage 1435 3552 7124 7040 3458 1436 3456 3554 7046 126014 54209 2209 10326 6772 695 6850 8651 3716 1540 2274 7186 9846 10454 29760 5336 2534 4689 10379 8517 1147 3551 10000 5599 5530 4791 4792 4772 4773 2355 4286 1385 5468 1513 54 799 3690 2353 PMC8120506__F2 Mitochondrial biogenesis signaling pathway is a potential therapeutic target for myasthenia gravis via energy metabolism (Review) 7019 4899 23411 PMC8122529__F2 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process 9817 9978 8452 2730 PMC8122529__F3 Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process 8452 9817 9978 2730 PMC8122924__F2 Lipin-1, a Versatile Regulator of Lipid Homeostasis, Is a Potential Target for Fighting Cancer 3479 3480 3667 387 7018 PMC8123211__F2 PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions 10039 142 84875 7431 6045 81847 154796 4040 4041 960 PMC8126715__F1 KRAS-Mutant Non-Small Cell Lung Cancer: An Emerging Promisingly Treatable Subgroup 1021 1019 2885 3845 387 2475 5337 6794 998 PMC8129027__F1 Study of the Regulatory Mechanism of the CB1/PPARG2/PLIN1/HSL Pathway for Fat Metabolism in Cattle 7808 3667 23411 3717 2308 5140 2167 4099 81616 51703 23305 2181 2182 5468 PMC8129499__F4 Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction 3553 7124 114548 5132 PMC8130302__F2 Effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation 1499 51176 6932 51701 4920 6010 PMC8131923__F4 Adipose tissue plasticity and the pleiotropic roles of BMP signaling 659 4090 4086 PMC8134874__F3 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells 5335 387 4485 9411 5338 5337 26524 9113 PMC8136122__F7 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) 355 857 1788 PMC8136436__F1 Biogenesis and clearance of H2S and reactive sulfur species 875 23474 58472 4357 PMC8138054__F3 Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances 27161 581 331 5999 1956 5243 6667 6774 6469 2475 2932 1000 960 9314 2050 998 1499 PMC8138567__F2 Curcumin as a Potential Treatment for COVID-19 59272 7113 1956 6868 2475 6774 PMC8141194__F1 Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review 494333 6023 55054 9474 693223 9776 2475 64422 10533 PMC8143192__F3 Therapeutic Potential of HUMSCs in Female Reproductive Aging 581 3082 3479 2475 PMC8143540__F2 Oxidative Stress in Cancer Cell Metabolism 572 581 5728 2475 3091 6714 5163 6648 PMC8143540__F3 Oxidative Stress in Cancer Cell Metabolism 572 637 581 7186 8772 PMC8144308__F2 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics 9575 406 1827 PMC8144890__F3 Energy metabolism disorders and potential therapeutic drugs in heart failure 2147 7249 7248 51256 6009 PMC8146403__F1 Transport Proteins Enabling Plant Photorespiratory Metabolism 847 5829 6470 PMC8146469__F1 Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2) 7432 2056 117194 90865 PMC8146608__F4 Influenza Virus RNA Synthesis and the Innate Immune Response 1283 7706 11035 197259 29110 3661 3665 57506 81030 PMC8148009__F3 Musashi–1—A Stemness RBP for Cancer Therapy? 6502 1021 1019 1874 993 1017 1869 1870 1871 8318 990 10926 8317 1111 PMC8148118__F3 Multifaceted Role of AMPK in Viral Infections 7249 7942 8408 3156 5337 23216 9759 10628 5209 10014 51564 7038 2308 PMC8148341__F2 Microglial Exosomes in Neurodegenerative Disease 4342 57162 11021 10652 PMC8154696__F10 An overview of ODE exposure induced mitochondrial dysfunction in microglia and BSCs 3661 55669 9927 7124 54106 65018 7019 115004 PMC8156813__F5 Sildenafil Alleviates Murine Experimental Autoimmune Encephalomyelitis by Triggering Autophagy in the Spinal Cord 9474 2475 627 PMC8159877__F4 Changes associated with IMR in the anterior leaflets at 4 weeks post-MI within the TGFB signaling pathway 3458 25805 7046 4090 4086 4091 4092 4087 4088 387 7189 4089 10454 23118 3398 PMC8160963__F2 Identifying Novel Actionable Targets in Colon Cancer 1499 324 2932 8945 8658 607 54623 8295 PMC8163070__F6 Phloretin protection against pathogen-induced mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) 7099 50507 1956 5595 5594 5599 4586 PMC8166871__F7 LIRCP-regulating network that connects autophagy and carcinogenesis 3456 3454 865 58484 1536 3339 7852 64127 6502 56253 114548 7099 6774 3667 10133 5591 1147 5037 5294 9675 5286 2475 54790 4089 238 80018 7405 253260 7046 156 8643 5566 5156 55704 10919 2155 1956 57521 7249 9365 3791 27148 8520 80208 83985 8301 5618 56848 2822 6241 11180 8723 27253 9711 115201 55288 79065 58476 1182 23339 23499 9895 2042 2048 79735 11337 23503 23192 64786 51256 79631 120892 55578 7402 64601 57192 6272 4943 55626 401548 1314 25782 200576 55770 9194 55102 387 2895 1612 673 81631 440738 55210 25851 9474 8742 545 23766 55201 3945 230 472 637 5579 11132 5315 2081 1777 8837 10848 2074 79054 7514 26227 23683 64419 8912 9520 1981 8897 2026 7357 9709 81537 8654 9451 4363 3098 1200 9611 4629 10857 4619 5211 66036 9817 8987 5213 5338 55613 5209 7350 4624 2335 10411 PMC8170402__F2 Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy 672 675 5888 7517 472 7518 PMC8178373__F2 Two common mechanisms of aurora kinase A (AURKA) synthetic lethal interactions 8289 6790 6597 5925 PMC8184591__F1 Network of Paf1C Functions 54617 1105 339287 55167 54623 27343 11201 PMC8185109__F3 Mitochondrial ER contact sites in neurodegeneration 351 9217 5091 90550 5662 65018 9927 2932 2521 8678 9474 PMC8186902__F4 HIF-1 signaling pathway with overlay data from differential expression and reporter metabolites analysis 3458 7099 7975 3939 2056 5163 7012 5211 2597 226 PMC8187363__F2 Involvement of RTK-RAS-MAPK accessory proteins in signal transduction 867 2885 4869 857 22808 2549 8036 55914 8826 7535 2444 4018 8682 10125 2273 161742 PMC8187363__F3 Involvement of accessory proteins in diseases 6714 2885 3932 7535 8826 8036 2273 613 9846 PMC8188209__F11 Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles 2271 1378 7448 715 716 PMC8188681__F2 Review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma 572 1019 1021 3091 4609 1977 4193 PMC8190181__F4 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer 2671 1956 2194 6722 10631 7412 9235 1386 1000 4312 7852 7291 999 PMC8192250__F1 Mechanisms linking gut microbial metabolites to insulin resistance 3667 208 5105 63976 7442 PMC8192371__F1 Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal Cancer 7099 1956 3902 958 8205 325 PMC8194305__F4 Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions 197259 8717 7186 6772 3716 3717 6774 3554 4615 51135 84818 7189 7297 3718 6775 6778 PMC8195803__F3 Revisiting the role of mitochondria in spinal muscular atrophy 83988 7317 55187 192111 4553 9927 PMC8196476__F3 Innate immunity, inflammation activation and heat-shock protein in COVID-19 pathogenesis 3606 114548 59272 3661 7098 51284 4615 3665 PMC8199999__F6 Minor Intron Splicing from Basic Science to Disease 6606 51808 25929 8487 3630 PMC8204012__F1 New Insights Into the Role of Autophagy in Liver Surgery in the Setting of Metabolic Syndrome and Related Diseases 10533 114548 3553 3606 7942 PMC8204904__F5 Proposed signaling pathway that involves slit2/Robo2 and Nox2 activation during retinotectal pathfinding 9353 6092 6649 PMC8207819__F1 Regulated cell death pathways at a glance 355 841 8772 8737 114548 79792 637 8717 10010 29110 581 317 331 81030 11035 197259 23657 11140 6520 3156 2879 90268 1540 5447 51706 81858 2182 7251 PMC8211386__F1 Apoptosis signaling pathways and pro-survival, immune, or tumor microenvironment influences that impact on them 2475 5728 596 637 581 8772 4170 8737 317 1493 331 468 545 472 4609 PMC8211386__F2 Cancer therapeutic approaches targeting apoptosis pathways 8772 4170 581 3845 572 1813 8192 4193 468 PMC8213343__F1 Targeting Bruton’s Tyrosine Kinase in Inflammatory and Autoimmune Pathologies 4067 6387 6850 3716 3717 695 958 6955 5971 930 108348016 613 3661 3458 3659 4118 4615 11316 7098 54106 51284 7099 PMC8213534__F1 TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review 7187 3661 3665 7098 8717 23118 10454 PMC8215340__F1 Metformin, Macrophage Dysfunction and Atherosclerosis 114548 948 7099 10333 38 57552 19 335 9619 7124 6347 6352 219699 1236 PMC8216565__F8 PI3K-AKT signaling pathway 6850 930 2885 5966 5728 7249 572 4193 6009 5934 150365 1975 PMC8216565__F9 MAPK signaling pathway 355 929 7186 1616 351 57136 2316 51701 5624 2002 8178 4149 PMC8216565__F10 Apoptosis signaling pathway 8772 1616 9049 468 9081 161823 2669 835 790 472 351 175 7974 PMC8219171__F6 An Examination of the Putative Role of Melatonin in Exosome Biogenesis 5566 1459 22943 7471 1452 7976 6259 4040 2033 6517 5336 4041 5607 7091 5076 PMC8220152__F3 Deubiquitinating Enzymes Orchestrate the Cancer Stem Cell-Immunosuppressive Niche Dialogue: New Perspectives and Therapeutic Potential 9097 7874 4193 50943 1499 4773 7375 6774 9958 648 23326 8205 PMC8221540__F8 Immunometabolic Endothelial Phenotypes 5209 2539 2147 5166 2308 PMC8222562__F1 SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining 10111 4361 5888 PMC8222669__F2 Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases 9817 9978 50507 1645 2729 1728 4094 PMC8225190__F6 Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response 5728 7249 7248 6009 7942 PMC8226792__F4 Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins 6655 22808 6237 83593 7074 5290 4301 5894 8315 51196 9610 10928 8036 5880 23179 5863 207 5898 8844 55770 5338 5062 387 1147 572 4303 29110 5970 598 356 998 8399 2002 2114 5966 PMC8227573__F1 An Insight into the microRNAs Associated with Arteriovenous and Cavernous Malformations of the Brain 161742 5728 7078 7076 PMC8229180__F1 AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells 1017 6502 1019 PMC8230587__F3 The Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson’s Disease 3065 3066 627 8877 11331 PMC8231924__F1 MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions 1003 9223 387 51421 2889 10276 5728 90952 81 7205 PMC8234323__F1 Asparagine: A Metabolite to Be Targeted in Cancers 440 468 83939 22890 PMC8234323__F3 Asparagine: A Metabolite to Be Targeted in Cancers 375 8140 4609 1977 440 468 920 3932 PMC8234963__F6 Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NFKB Signaling Pathway and NLRP3 Inflammasome Activation 7099 114609 4615 114548 7124 4513 PMC8235370__F1 Coronavirus RNA-Processing Enzymes in Innate Immune Evasion 6772 6773 10379 PMC8236816__F1 Targeting of Lysosomal Pathway Genes for Parkinson's Disease Modification: Insights From Cellular and Animal Models 120892 8934 55737 1509 79065 23400 PMC8236819__F2 Pathophysiologic Role of Neurotransmitters in Digestive Diseases 4318 4313 154 1813 1956 114548 PMC8247594__F3 Evolution of Our Understanding of XIAP Deficiency 7186 1611 64127 11035 10487 10486 23118 257397 10454 331 7099 8772 114548 5879 7124 6850 3454 PMC8249521__F3 Introducing the novel Cytoscape app TimeNexus to analyze time-series data using temporal MultiLayer Networks (tMLNs) 5426 1690 10051 325 23649 991 5884 6343 PMC8249562__F4 Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease 11331 6774 1869 1000 65018 581 3004 10131 7416 3297 10682 PMC8257776__F1 Molecular pathways of apoptosis and necroptosis 637 581 1540 8717 8772 197259 PMC8261484__F1 NAD+ synthesis pathways 125061 8564 8942 23498 55315 3177 222962 2030 84561 340024 130013 23475 10135 160728 9390 93100 23098 PMC8261594__F5 Study on the mechanism of the Modified Ginseng-Schisandra Decoction (MGSD) in the treatment of recurrent respiratory tract infection (RRTI) based on network pharmacology 9365 759 5966 4149 PMC8264290__F1 Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm 7124 7186 7187 197259 8772 83737 3725 717 718 3596 9021 2353 64127 6401 PMC8266859__F8 Possible role of BA3/A1-crystallin in the EGFR signaling network and RPE polarity 1956 1411 6120 PMC8268239__F5 Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications 7965 3569 2629 1644 PMC8269036__F2 mRNA-miRNA-lncRNA Regulatory Network in Nonalcoholic Fatty Liver Disease 5550 100187761 3170 51421 4771 4089 10413 8463 PMC8270322__F1 Pros and Cons of the Cannabinoid System in Cancer: Focus on Hematological Malignancies 581 5281 1017 PMC8273570__F1 Three modes of IL-6R signaling and their associated intracellular pathways 6654 2885 2549 9021 6774 8651 PMC8274905__F6 Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NFKB Signaling Pathway in Bovine Mammary Epithelial Cells 4049 7097 2876 4513 3553 PMC8280023__F3 Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment 51024 581 4976 55669 PMC8281237__F1 Amino Acid Metabolic Vulnerabilities in Acute and Chronic Myeloid Leukemias 26227 29968 5723 875 1491 6472 6470 586 587 5625 2747 2744 440 445 5053 435 PMC8285540__F7 Model depicting the role of FBXO32 in the crosstalk between CHOP-dependent apoptosis and autophagy 1386 596 836 3920 PMC8290157__F1 RNA Polymerase III, Ageing and Longevity 27343 11201 4609 84232 PMC8290198__F1 Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events 2885 920 3932 5335 3702 940 8631 969 4485 PMC8290884__F2 Selective Neuron Vulnerability in Common and Rare Diseases—Mitochondria in the Focus 120892 9927 4976 65018 10133 4342 54332 55737 PMC8294090__F11 Butorphanol Promotes Macrophage Phenotypic Transition to Inhibit Inflammatory Lung Injury via K Receptors 4615 383 3665 PMC8295688__F1 Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection 59272 7113 114548 3553 79792 3458 PMC8299209__F2 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway 4920 387 1499 51701 2534 6774 PMC8299209__F3 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway 7187 3661 51135 7189 8195 257397 23118 3725 3553 1499 51701 PMC8301100__F2 Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease 65018 2932 2534 PMC8301439__F3 IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications? 2744 3418 586 587 10135 5156 PMC8301837__F3 Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells 5879 5058 7942 10397 26168 PMC8303222__F2 Importance of Being PI3K in the RAS Signaling Network 2885 5728 5163 1499 695 PMC8304710__F2 Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer 3939 2597 3099 5230 26227 5211 2023 5315 5163 5723 6472 10797 25902 23462 65018 56901 4601 PMC8305013__F1 Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention 3815 4286 1638 PMC8306430__F3 Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation 9021 5699 23152 713 55008 2567 2562 2554 2561 2752 50944 PMC8306455__F4 Evasion of the Host Immune Response by Betaherpesviruses 8772 5728 2475 1950 1956 5163 581 596 PMC8306508__F5 Acquisition of New Migratory Properties by Highly Differentiated CD4+CD28null T Lymphocytes in Rheumatoid Arthritis Disease 7414 3683 4018 2149 2152 387 399 5879 7070 10152 5880 998 324 7408 PMC8306625__F4 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases 2744 3661 57506 50506 7187 3665 PMC8310117__F2 SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications 7018 3603 3553 7450 7113 PMC8310855__F3 Cannabinoids in the landscape of cancer 468 57761 79054 51393 7442 26471 572 9290 387 1386 PMC8314387__F3 Signaling Pathways Involved in Diabetic Renal Fibrosis 5163 4087 4088 1499 PMC8322647__F1 Contemporary View of Natriuretic Peptides in the SARS-CoV-2 Era 59272 5879 594857 PMC8323660__F2 Epigenetic Changes in the Progression of Alcoholic Steatohepatitis 23410 51548 4520 23411 402682 51569 51506 80339 PMC8323674__F1 Research trends, hot spots and prospects for necroptosis in the field of neuroscience 7124 401262 7099 197259 7098 PMC8326120__F4 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue 5728 64798 2475 64223 7248 7249 6009 7038 2932 253260 7350 7054 PMC8326120__F5 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue 7248 7249 2638 7038 63976 7350 7442 162514 51393 59341 PMC8326283__F8 Liquid–liquid phase separation in human health and diseases 8405 1616 907 PMC8328776__F3 High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury 9536 6354 23529 2919 6403 4314 3146 7099 4513 983 3055 3142 4067 6464 51083 4615 6770 PMC8335696__F7 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway 1956 3383 6401 2885 4615 3717 51135 3654 6774 5604 23118 10454 5602 2113 2002 6722 1432 4312 7412 PMC8335817__F1 Interleukin‐25: New perspective and state‐of‐the‐art in cancer prognosis and treatment approaches 7189 64806 55540 8717 6774 8772 1956 PMC8338901__F2 Contributions of EV cargoes in inflammation in CVD 7412 4615 3654 7189 355 961 948 2475 5163 PMC8340019__F4 Jasmonates, Calcium, and Glutathione in Plants to Combat Abiotic Stresses Through Precise Signaling Cascade 5596 2077 4609 PMC8342764__F3 Cerebral Autoregulation in Subarachnoid Hemorrhage 7124 8877 1080 PMC8343402__F5 Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants 2937 79017 8994 5720 2729 6240 6647 275 4763 2678 4609 23411 7428 2033 5698 5686 10213 5699 5694 5696 143471 64344 5557 6241 8318 2309 5716 5719 5715 5682 5688 1111 983 54892 2353 4851 4172 9735 4790 5691 5426 4175 2308 5595 3725 847 6469 580 6648 5052 3516 4855 401541 2879 2736 9212 3303 3313 5347 4176 4171 4173 5905 57551 3306 3315 2146 467 3309 5526 8813 22926 3832 699 10592 3312 6185 1798 8704 7494 9918 64151 27125 201595 6812 6184 3703 4905 25839 84342 9382 22796 10466 4245 4124 10905 8775 63908 8774 4122 9527 27333 55738 10113 1639 22872 10382 27077 1781 1778 1783 11015 6711 10228 57545 7846 4867 9570 26123 10133 261734 5108 PMC8344275__F1 Deregulation of HLA-I in cancer and its central importance for immunotherapy 3454 3455 3459 3460 3659 567 5163 1956 7046 PMC8344376__F2 SASP regulation 1777 11277 472 3661 23476 2626 6781 4312 2475 PMC8345973__F1 Gasotransmitters for the Therapeutic Prevention of Hypertension and Kidney Disease 875 847 1610 PMC8345975__F1 Cardiomyocyte Proliferation as a Source of New Myocyte Development in the Adult Heart 983 1017 5166 1018 1021 1020 1019 2066 3084 2064 4485 81532 9113 26524 PMC8348158__F8 Transcriptomic and Metabolic Network Analysis of Metabolic Reprogramming and IGF-1 Modulation in SCA3 Transgenic Mice 3479 6009 51206 4694 3480 2690 3717 207 5163 PMC8353915__F6 VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines 9097 468 4149 83939 7494 100 22926 PMC8355346__F1 Molecular mechanisms and signaling pathways of ferroptosis interact with AS 7099 467 57817 23657 6520 2879 PMC8356007__F7 Exploring the Pharmacological Mechanism of Liuwei Dihuang Decoction for Diabetic Retinopathy: A Systematic Biological Strategy-Based Research 2241 7010 5328 6401 2645 3265 3815 3643 695 PMC8357839__F6 Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats 6774 9817 7019 4118 PMC8358862__F8 Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy 9817 6469 7099 114548 10628 6608 PMC8360618__F3 MUC1 is an oncoprotein with a significant role in apoptosis (Review) 355 8772 637 331 4582 581 150365 PMC8361327__F1 Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer 23705 122786 60485 4485 10413 PMC8364652__F5 Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy 545 472 4193 581 468 PMC8364652__F6 Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy 9817 136259 1728 847 6647 6648 5052 10935 9388 3845 472 672 PMC8369417__F1 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases 5879 7189 54209 126014 6850 4772 399665 1513 100187907 4286 81501 695 29760 5336 10451 998 PMC8369417__F5 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases 7124 7097 695 4772 4067 54106 51284 PMC8377368__F1 Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity 324 90865 64806 2625 6095 29851 50943 912 355 PMC8387351__F1 Stress response pathways dysregulated with age and injury: 22926 338386 468 PMC8387356__F1 Influence of diets on metabolites and the epigenetic machinery 1636 8473 10724 84295 9055 PMC8387624__F5 Functions of Hepatitis B Virus Encoding Proteins: Viral Persistence and Liver Pathogenesis 1017 1499 652995 2146 8847 728655 6774 9582 PMC8389838__F5 Targeting Small GTPases and Their Prenylation in Diabetes Mellitus 5898 3667 5058 5879 9882 998 387 100170220 PMC8391653__F2 Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation 4040 6608 51684 1499 4089 4088 4087 100 1277 1281 60485 6010 4485 23462 3280 23493 PMC8391678__F2 LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases 627 1283 6010 5881 5879 3984 5058 9475 406924 PMC8392047__F1 Selective Autophagy in Hyperglycemia-Induced Microvascular and Macrovascular Diseases 22926 468 9140 10533 9474 83734 64422 23192 7249 7248 8408 9776 60673 22863 PMC8392326__F2 Inborn Errors in the LRR Domain of Nod2 and Their Potential Consequences on the Function of the Receptor 942 941 940 64127 3661 7187 57506 PMC8392679__F3 Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression 5728 60674 89780 148189 1499 6925 7503 4193 63941 2625 383 9332 100422829 149775 PMC8393318__F8a Gastroprotection against Rat Ulcers by Nephthea Sterol Derivative 572 1147 5728 1385 6199 7249 2475 PMC8394001__F3 Guardians of the Genome: BRCA2 and Its Partners 5888 50485 6596 84893 80198 201973 4361 9156 1763 79728 675 672 2177 2175 7428 10714 PMC8394096__F1 Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review 581 572 331 4193 5058 5728 207 PMC8394324__F4 Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer 5728 6009 7249 7248 PMC8395233__F1 Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF 6714 5879 1003 3553 3383 7412 PMC8395431__F1 TNFA and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer? 8772 8717 7186 5966 PMC8396181__F2 Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects 25831 4035 4036 80199 4628 PMC8396560__F1 Macrophage Motility in Wound Healing Is Regulated by HIF-1A via S1P Signaling 6347 729230 4088 8877 2475 3569 3586 114548 387 5879 PMC8399382__F1 Metabolic Host–Microbiota Interactions in Autophagy and the Pathogenesis of Inflammatory Bowel Disease (IBD) 64127 345611 55054 9140 9474 PMC8399643__F3 Regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease 468 7494 22926 6668 6667 PMC8399842__F1 Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine 7124 4843 6774 1576 PMC8401922__F3 AMPK and Its Downstream Signals in Pain Regulation 1435 1436 7249 64223 8408 PMC8416054__F2 Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease 5132 54106 51284 4615 3663 3665 3654 3684 7128 2212 941 11027 958 640 26191 25780 4067 971 7124 1445 6775 10125 1493 PMC8416576__F4 Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis 10130 5954 5589 5034 7184 337 5265 1 6678 5340 259 7422 1950 5950 183 7040 PMC8417882__F2 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges 150365 56616 331 8772 PMC8422639__F11 Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells 3146 9790 8205 PMC8427766__F3 COVID-19 Immunobiology: Lessons Learned, New Questions Arise 4615 929 7124 3569 6347 942 941 51284 51311 51135 3654 23118 257397 10454 7189 114609 7099 57506 3661 7187 6773 7297 3716 10379 6772 PMC8427766__F4 COVID-19 Immunobiology: Lessons Learned, New Questions Arise 57506 29110 3661 7187 6773 10379 3716 6772 PMC8430477__F1 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 1977 2475 8408 7001 2882 23410 PMC8431111__F10 circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway 55727 27161 5598 PMC8431385__F2 Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts 8743 4049 8795 8784 8718 1147 3551 8517 4793 4794 6955 5966 6416 5602 578 599 598 596 4170 4193 1029 581 7157 8837 10018 572 4609 637 8739 54205 27113 666 355 356 56616 317 1677 3002 843 842 5551 332 837 840 835 834 3660 3661 3480 3662 3664 3481 207 PMC8431490__F3 The BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin 4052 581 7412 920 6774 1499 7422 PMC8431732__F2 Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases 6667 3725 3845 4609 196 2534 9817 192111 10072 79728 8878 672 PMC8431803__F1 Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier 1103 1356 43 1555 130749 PMC8433920__F5 Phytochemicals from Polyalthia Species: Potential and Implication on Anti-Oxidant, Anti-Inflammatory, Anti-Cancer, and Chemoprevention Activities 6714 1499 998 5879 4318 4313 983 3717 2146 1017 23512 2475 1021 1019 5111 1956 4303 572 581 PMC8435845__F3 Research Progress on the Structure and Function of G3BP 51083 4313 5728 6696 7124 338376 PMC8436866__F2 Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease 1810 10628 2932 114548 1998 468 7494 581 19 2475 PMC8436873__F1 Impaired macrophages and failure of steroidogenesis and spermatogenesis in rat testes with cytokines deficiency induced by diacerein 4282 1583 6770 114548 9332 834 367 PMC8437760__F2 Induced pluripotent stem cell-based disease modeling and prospective immune therapy for coronavirus disease 2019 6657 79923 64321 3170 1003 947 1950 6295 920 84525 4586 93986 6662 362 PMC8438230__F3 Glioma Stem-Like Cells and Metabolism: Potential for Novel Therapeutic Strategies 3099 3939 5163 5091 3418 2746 2875 2744 PMC8439382__F1 The UPR Pathway in the Pathophysiology and Treatment of Bipolar Disorder 83939 468 22926 PMC8449777__F7 Schematic showing the mechanisms underlying miR-2337 induction of TGFB1 production in GCs 27161 4088 7046 7048 PMC8453146__F2 Kill and Clearance in HCC: An Approach Based on NK Cells and Macrophages 8205 1524 6347 6376 383 6352 6351 6348 958 PMC8455891__F1 Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis 51506 51185 899 80204 23219 79791 23291 253980 55975 80311 23221 4287 161725 7874 10617 8239 11274 23326 389856 8925 8450 9820 57531 8452 83737 64207 90678 57520 10075 11043 378884 4281 23327 54551 54941 5071 81790 165918 55521 10273 54476 84231 23321 4591 9320 7337 55148 5702 5718 5689 PMC8458575__F2 Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism 468 10797 790 7249 7248 5163 PMC8458764__F1 Metabolic Contributions of Wnt Signaling: More Than Controlling Flight 4040 4041 1499 324 6934 387 6259 998 5879 PMC8463930__F8 Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation 4049 929 847 7124 114609 4615 7189 7186 7187 4149 3586 100653365 4803 8772 4703 8205 7975 4513 914 126669 5447 6401 PMC8465283__F1 p53 mRNA Metabolism Links with the DNA Damage Response 472 9656 51426 7508 1647 672 10733 545 3364 581 5884 84126 11073 5371 PMC8465440__F2 Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway 3782 873 1066 5447 1514 7498 9212 4842 55872 207 9360 2324 695 4067 5770 240 4353 1520 7297 4214 9020 9448 7010 7052 4835 6401 768 9261 3551 4846 857 5599 3791 6850 1956 1890 1432 5159 3480 6714 3320 9891 1513 5140 6790 5788 2100 5606 673 6198 2932 3643 23621 9252 4170 11040 5783 415116 759 23173 771 762 4128 2859 PMC8465902__F4 Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer 22 55847 493856 27158 57019 10539 4693 4682 64428 9391 51647 64210 PMC8468947__F1 Lactoferrin and Its Potential Impact for the Relief of Pain: A Preclinical Approach 7099 4615 3654 51135 7189 3569 3606 PMC8469696__F2 Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer 92305 79609 64431 6992 54739 258010 127733 137886 5510 80700 54221 80124 7415 25949 79058 55829 7353 7993 197320 9373 26043 9709 55432 54890 91544 51808 2547 PMC8469761__F1 Glycosylation in Vascular Calcification 650 4086 4090 860 8074 1499 2475 PMC8470500__F1 Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders 3383 7124 3553 PMC8470500__F2 Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders 114548 4284 7099 1401 PMC8471303__F1 Age-Dependent Decrease in Hepatic Geranylgeranoic Acid Content in C3H/HeN Mice and Its Oral Supplementation Prevents Spontaneous Hepatoma 3652 4129 26088 PMC8472292__F2 On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease 387 6259 51701 998 22943 1499 324 PMC8479832__F2 Purinergic signaling in the modulation of redox biology 836 84890 114548 834 847 3553 PMC8492658__F6 Cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients 183 59272 1636 8862 185 PMC8493693__F4 Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis 4535 4694 6392 6389 6391 4541 4539 4537 4540 4538 4536 6390 7386 4519 7381 1537 9377 1350 1353 4512 4513 1349 1352 1329 1345 1346 10063 4514 1355 516 539 9551 10632 515 4508 479 498 1351 PMC8495158__F2 Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells 5447 1311 6395 351 5728 5091 3952 PMC8495202__F2 Desmosomes as Signaling Hubs in the Regulation of Cell Behavior 5318 1829 1830 1823 1832 1828 11187 147409 5317 1956 1950 PMC8504100__F2 Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives 8205 10413 1116 920 9242 6774 6374 2920 2191 6372 23529 6361 6367 5159 968 729230 6352 50943 1803 7852 7054 85480 54443 81624 100507436 5817 2919 PMC8505078__F6 Exploring the Mechanism of Resveratrol in Reducing the Soft Tissue Damage of Osteoarthritis Based on Network Pharmacology and Experimental Pharmacology 4049 7010 929 7216 100187907 6955 6886 351 4117 100187761 5627 26136 PMC8507396__F2 PLCG1 in regulation of VEGFR2 and FGFR1 signaling 2885 2260 10818 5335 PMC8509311__F1 Impact of Selenium Deficiency on Cardiovascular Function 51540 22928 6414 51714 58515 51734 6415 PMC8510449__F5 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review 1956 999 6935 960 100133941 9839 PMC8511346__F1 Sleep and Diet: Mounting Evidence of a Cyclical Relationship 121278 7166 15 PMC8511501__F6 Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway 5604 2885 5770 4791 5781 PMC8514750__F4 GTPase-Dependent Mitochondrial Dynamins in Heart Diseases 23411 23410 6613 6612 205564 983 4485 PMC8514848__F1 RASopathies: From germline mutations to somatic and multigenic diseases 317 581 596 161742 673 11319 1431 867 4763 369 2475 PMC8516728__F2 Triumvirate of NFKB, inflammation and cytokine storm in COVID-19 6868 6774 59272 7113 7098 51284 3665 3466 6773 10379 8717 PMC8517843__F3 ADAMs family in kidney physiology and pathology 1956 58191 59272 50507 PMC8518663__F1 Manipulation of auxin signalling by plant viruses 7175 8454 6500 PMC8518663__F2 Manipulation of auxin signalling by plant viruses 1283 6500 7175 8454 PMC8524061__F1 Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy 6714 1611 126669 2885 2549 PMC8524061__F5 Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy 208 4193 100187761 4087 4088 999 2932 2534 468 26291 23411 PMC8524104__F1 Lactate in the tumour microenvironment: From immune modulation to therapy 2475 3945 3939 2597 PMC8529160__F4 Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury 4117 102 6868 PMC8532088__F2 Influenza virus RNA polymerase as an innate immune agonist and antagonist 7706 6048 3661 57506 4077 29110 3665 7187 23087 PMC8533628__F13 Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45 7275 847 27035 4025 PMC8533628__F16 Inhibition of Membrane-Associated Catalase, Extracellular ROS/RNS Signaling and Aquaporin/H2O2-Mediated Intracellular Glutathione Depletion Cooperate during Apoptosis Induction in the Human Gastric Carcinoma Cell Line MKN-45 27035 4025 847 PMC8534156__F5 Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers 8139 6714 867 1384 PMC8534692__F7 Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice 2168 3101 80201 6518 5223 84532 79611 95 134526 80168 6646 6309 6307 50814 2222 4864 PMC8534848__F2 Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment 5971 3620 7040 9021 6714 6693 847 196 PMC8535782__F1 Control of ovarian follicle development by TGFB family signaling 283120 650 652 2661 9210 3815 26585 64388 PMC8538727__F2 Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects 125061 8564 8942 93100 23475 64802 349565 23057 10135 952 PMC8539574__F2 Glycation and Glycosylation in Cardiovascular Remodeling: Focus on Advanced Glycation End Products and O-Linked Glycosylations as Glucose-Related Pathogenetic Factors and Disease Markers 2821 64841 8473 10724 PMC8547806__F3 Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGFB/Wnt/Beta-Catenin Pathways and PPARG 7046 7099 1499 324 PMC8551128__F1 Complement activation in IgA nephropathy 1195 10747 5648 717 715 716 727 966 729 2271 PMC8554863__F11 CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NFKB/STAT3 signaling pathway 643 9474 6774 PMC8555307__F4 Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma 7098 7187 3661 51311 51284 54106 4615 51135 7189 3665 7096 7097 10333 114609 23118 10454 7100 81793 3663 8772 7099 PMC8557169__F4 Turning scientific serendipity into discoveries in breast cancer research and treatment: a tale of PhD students and a 50-year roaming tamoxifen team 581 637 8772 PMC8557391__F2 Nrf2/Keap1/ARE signaling: Towards specific regulation 8452 9817 4094 PMC8560795__F2 Targeting Sphingolipids for Cancer Therapy 6611 95 1674 8877 6696 PMC8560908__F4 The interplay between MAPK signaling and ARTD family members 142 4342 54625 80351 468 PMC8562402__F1 Therapeutic effect of oxygen-ozone in controlling of COVID-19 disease 9817 114548 1401 PMC8566112__F6 Ether lipid synthetic pathway 55711 84188 8540 8443 25979 4018 PMC8566568__F5 RNASeq analysis of drought-stressed guayule reveals the role of gene transcription for modulating rubber, resin, and carbohydrate synthesis 38 39 3652 PMC8570953__F1 Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway 8772 3716 355 581 PMC8572027__F2 Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures 3553 114548 7189 4094 PMC8572812__F2 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases 3479 2475 6774 383 4088 PMC8573085__F1 Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease 4023 355 948 5465 PMC8577691__F3 STRING analysis of habenular proteins with increased levels after (−)-menthol exposure 4763 5706 7337 5713 63891 10213 29882 5709 908 4734 164 6950 7203 10606 8027 5092 121278 6697 50813 5536 80331 57551 7514 3837 1069 2572 673 10844 56474 7277 85378 226 1639 22872 9632 318 80006 6399 58485 2717 2194 PMC8582360__F2 HGF/MET Signaling in Metastatic Uveal Melanoma 3082 5879 6714 2549 2885 6774 2475 PMC8582658__F2 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions 3939 5300 4040 4041 324 2932 1499 PMC8582658__F3 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions 5163 5164 4040 4041 1499 595 3939 6774 PMC8583405__F7 Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway 6657 79923 10533 9140 8408 PMC8584042__F2 Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface 6010 6722 6714 9113 26524 100187761 9780 PMC8584162__F2 Defining Pathological Activities of ALK in Neuroblastoma, a Neural Crest-Derived Cancer 10818 238 126669 4613 1740 2119 3718 6774 3667 2885 6714 PMC8584291__F1 Senolytics: A Novel Strategy for Neuroprotection in ALS? 355 8772 317 572 581 1017 1021 1019 PMC8591899__F1 SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities 59272 57506 7113 3627 6347 3569 3565 920 3458 3558 59067 PMC8593497__F1 Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels 95 7124 6319 3953 6093 23411 PMC8599300__F4 Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome 3929 929 2002 7124 7186 9261 6722 2 1401 3717 6774 8651 9021 PMC8599717__F2 Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology 56339 9589 79068 253943 54915 51441 1233 54464 PMC8602044__F4 Plasma triacylglycerols are biomarkers of Beta-cell function in mice and humans 6487 79837 4706 3030 51144 6482 2581 81579 55529 3284 64781 55326 10825 145567 51170 123099 56895 57406 26207 7421 2819 7167 4725 4720 4729 4726 4696 4731 4698 4697 4705 4704 51079 4709 4710 4711 4715 7388 7385 7381 1345 1347 1350 1349 515 1340 PMC8605121__F2 Dysfunction of miR‐802 in tumors 768219 324 1499 25925 5901 1956 2260 2475 5728 6608 51684 51715 PMC8605459__F1 Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence 196 405 1544 57491 7054 3569 1316 999 PMC8605871__F7 Whole Exome Sequencing Study in a Family with Type 2 Diabetes Mellitus 3479 3630 1080 948 3643 2147 7249 6009 2475 355 8408 PMC8607389__F2 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease 54209 2885 6654 79930 348 6850 2475 5728 10451 7410 27040 998 PMC8610843__F1 Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications 59272 8829 7113 7097 PMC8611677__F5 Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder 6993 5028 10316 51804 27164 1230 3062 5032 1912 6657 6714 8811 2078 1903 55243 7482 100996758 5540 5937 29923 4889 30817 976 8111 23533 PMC8612763__F6 Metabolic changes associated with replicative lifespan (RLS) 252842 2023 5131 2819 PMC8613465__F1 Signaling pathways and intervention therapies in sepsis 3146 7099 2879 10628 79792 3606 3091 29110 115004 3661 4615 10454 1956 238 3065 PMC8613465__F2 Signaling pathways and intervention therapies in sepsis 7099 3146 79792 9447 3065 83667 65018 2475 PMC8615223__F5 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights 596 581 572 317 355 8772 983 1017 1021 1019 PMC8615881__F1 Matrix Metalloproteinases in Endometriosis: A Potential Target 1956 3718 146433 6778 4316 10963 27178 4318 4313 3717 6774 4513 2243 4314 4319 PMC8616058__F1 Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics 100170220 7054 7314 5338 11021 PMC8619695__F4 Protein Misfolding and Aggregation: The Relatedness between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders 83939 7494 22926 PMC8624719__F1 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes 4615 51284 7098 29110 3661 3665 57506 55669 9927 115004 PMC8625890__F8a Clinically Relevant Genes and Proteins Modulated by Tocotrienols in Human Colon Cancer Cell Lines: Systematic Scoping Review 4434 1636 2078 2885 836 324 572 7808 4089 2956 581 51426 PMC8626287__F2 Implication of the circadian clock in the regulation of neural signaling and behavior 2475 8864 627 406 9575 4853 9456 1843 7249 7248 PMC8628488__F2 Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides 3643 5164 5163 2932 PMC8630984__F1 Mapping the molecular architecture required for lipid-binding pockets using a subset of established and orphan GPCRs 4018 53836 10161 2859 2857 5731 5732 5729 5734 5733 5739 5737 6915 10936 2358 56413 2854 PMC8632544__F1 Wnt/Beta-Catenin-Dependent Transcription in Autism Spectrum Disorders 4040 4041 324 1499 6259 3725 387 6010 PMC8636224__F1 Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics 1956 382 7251 928 967 975 PMC8636279__F2 Helminth extracellular vesicles: Interactions with the host immune system 90865 6761 2475 942 PMC8636938__F2 Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries 2475 196 619501 PMC8639147__F10 Mechanistic model of REST-dependent homeostatic rearrangement of inhibitory inputs in response to hyperactivity 5978 266743 140679 2571 PMC8641543__F1 Oncogenic factors regulate cancer cell metabolism 5163 2475 4609 4149 PMC8641543__F5 Inhibitors of nucleotide synthesis 5471 26227 1723 4522 6470 6536 94081 6472 10797 25902 54977 7298 PMC8642426__F2 Pharmacological insights into autophagy modulation in autoimmune diseases 8678 5071 9474 7939 64422 10533 9140 4280 115004 7098 55054 64127 8408 345611 5289 920 PMC8646045__F7 Activation of A7nAChR Protects Against Gastric Inflammation and Dysmotility in Parkinson’s Disease Rats 4513 3553 9332 968 PMC8649922__F1 Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy 3949 948 23411 3156 2194 47 7038 55902 PMC8650380__F4 Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications 7099 4615 54209 7412 3383 4155 4035 PMC8650620__F2 In Sickness and in Health: The Oxygen Reactive Species and the Bone 5741 50507 27035 1499 860 PMC8651533__F2 Proline metabolism and redox; maintaining a balance in health and disease 5832 4942 8659 65263 29920 5625 PMC8652287__F2 Biological Adaptations of Tumor Cells to Radiation Therapy 857 100188011 22926 83939 51660 23410 3831 PMC8655231__F2 Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease 1499 5826 1540 4615 3654 23118 257397 PMC8656040__F1 Ketone bodies: from enemy to friend and guardian angel 3158 3155 622 PMC8656547__F2 Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma 4092 4088 4087 4089 23642 10454 54997 1386 55000 PMC8657427__F7 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches 1431 2744 95 2194 948 PMC8657471__F4 EREG/EGFR Pathway in Tumor Progression 1956 2069 374 2064 3717 6774 999 1000 5874 PMC8660088__F6 System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer 1440 7097 7099 930 613 6850 1441 10257 2885 1080 5879 3667 5290 146850 5163 5894 572 6256 4609 595 4602 627 2353 3725 268 PMC8661100__F3 Evidence of myomiR regulation of the pentose phosphate pathway during mechanical load‐induced hypertrophy 94081 26227 6472 10797 29968 6470 5723 4522 81539 PMC8662361__F6 Aging Affects KV7 Channels and Perivascular Adipose Tissue-Mediated Vascular Tone 4149 6390 6391 5566 5291 5296 4190 4191 6720 5467 6256 6258 1431 48 50 8802 6342 123 440503 7316 31 2194 2171 9415 PMC8663543__F1 CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases 2717 3033 7054 10750 4118 11113 847 367 4099 4018 7018 PMC8668291__F1 Plant-Derived Chinese Medicine Monomers on Ovarian Cancer via the Wnt/Beta-Catenin Signaling Pathway: Review of Mechanisms and Prospects 999 1499 4040 4041 324 PMC8670437__F7 In situ Metabolomics of Metabolic Reprogramming Involved in a Mouse Model of Type 2 Diabetic Kidney Disease 6303 355 51380 3067 PMC8674309__F1 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment 7097 7099 4615 51135 3654 3656 3725 7189 23118 257397 3663 54106 51284 5970 7098 7187 29110 3553 3606 3569 57506 3661 115004 3455 10379 6772 3454 7297 3588 163702 3716 PMC8687677__F1 The Role of Gut Microbiota in Diabetic Retinopathy 114548 7099 4615 3240 PMC8688453__F1 Mitophagy process 139341 65018 665 11331 PMC8695855__F1 Pharmacological Applications and Action Mechanisms of Phytochemicals as Alternatives to Antibiotics in Pig Production 7099 3550 4703 23411 PMC8696218__F6 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 116519 1376 4312 PMC8698717__F3 Neutrophils and Platelets: Immune Soldiers Fighting Together in Stroke Pathophysiology 3383 3579 4512 7412 7450 PMC8699029__F1 System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach 7124 3952 8717 7186 6774 5465 9021 2475 5443 181 4852 PMC8699227__F7 Cell Cycle Progression by Growth Factor-Induced Cell Signaling 2002 1019 5728 PMC8699381__F3 Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches 1956 387 1386 9290 7442 7494 581 759 472 PMC8699653__F2 Methylation Markers in Cutaneous Melanoma: Unravelling the Potential Utility of Their Tracking by Liquid Biopsy 5728 572 4255 472 545 266710 PMC8700759__F6 C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance 837 637 4170 7124 27429 581 6093 2620 56616 317 2021 PMC8700948__F1 Regulatory Effects and the Signaling Pathways of Natural Bioactive Compounds on Ferroptosis 100 2182 10162 6520 2879 7037 8031 PMC8701046__F1 Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication 5888 675 79728 672 580 5889 7517 5890 5892 7516 126074 PMC8702253__F8 Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking 3565 3569 5781 50964 5894 3586 2885 3265 3587 7424 1950 2069 7422 5228 7423 7039 6774 1956 3791 6654 3845 3667 PMC8703161__F4 Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration 8213 9965 58191 PMC8704776__F2 Telomeres and Cancer 1200 55505 55651 9295 80169 PMC8705083__F1 Eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles 84890 1984 1725 83475 PMC8705762__F3 Sperm-Guiding Unconventional Prostaglandins in C. elegans: Synthesis and Signaling 3630 9798 208 207 5163 6446 PMC8712140__F13 To Predict Anti-Inflammatory and Immunomodulatory Targets of Guizhi Decoction in Treating Asthma Based on Network Pharmacology, Molecular Docking, and Experimental Validation 1435 1896 2885 1956 6885 10454 9020 10000 8517 1147 3551 5294 5894 4792 4790 5970 5604 5605 3603 7124 PMC8714756__F5 Adaptation Strategies to Improve the Resistance of Oilseed Crops to Heat Stress Under a Changing Climate: An Overview 10006 54861 51225 PMC8714827__F3 EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer 6714 2885 4615 5728 2475 1950 1956 PMC8716792__F2 Ferroptosis Signaling and Regulators in Atherosclerosis 2539 2879 4094 7018 PMC8718819__F1 Rho GTPase signaling in rheumatic diseases 6010 3371 10216 6774 5058 998 4318 4322 5879 4314 4513 29851 4843 PMC8721241__F3 Updated role of ABA in seed maturation, dormancy, and germination 5600 54861 51225 PMC8722265__F8 SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression 3586 383 3565 6778 285958 7186 7099 PMC8722734__F3 Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases 2309 637 27250 79940 4175 100422868 9191 2308 100126297 100144748 PMC8727603__F2 Rotavirus Interactions With Host Intestinal Epithelial Cells 6772 3466 4599 6773 10379 7098 57506 3627 3661 PMC8732359__F1 LncRNA Expression Profiles in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets 219539 8638 4940 4939 60674 920 55384 100124700 283120 7503 102464837 403323 9475 2475 64127 6382 4050 PMC8740020__F2 Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design 7494 22926 467 1998 468 PMC8741355__F4 Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics 335 2170 4023 65057 5360 3611 7316 1581 1962 PMC8741373__F11 Identification of Potential Biomarkers of Depression and Network Pharmacology Approach to Investigate the Mechanism of Key Genes and Therapeutic Traditional Chinese Medicine in the Treatment of Depression 7187 4117 23269 PMC8745298__F2 Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease 83939 468 22926 2744 6668 6667 627 7494 7186 PMC8745569__F1 Intriguing Thyroid Hormones–Lung Cancer Association as Exemplification of the Thyroid Hormones–Cancer Association: Three Decades of Evolving Research 2475 7216 1428 PMC8745614__F5 Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells 1356 2948 2944 23111 8751 7402 9877 50809 476 6631 11030 7076 2778 6919 1281 7171 50484 PMC8746472__F3 Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms 596 581 1786 1019 PMC8747665__F7 Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds 5447 4313 9210 654 3643 3949 2492 4513 PMC8750192__F8 Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis 7097 114609 4615 7189 6347 7124 PMC8750666__F9 Building a Foundation for Precision Onco-Nutrition: Docosahexaenoic Acid and Breast Cancer 5091 9776 8408 1977 3643 7249 7248 6009 1975 5163 6010 6194 1999 3667 PMC8761731__F11 Predicting 3D Structure, Cross Talks, and Prognostic Significance of KLF9 in Cervical Cancer 6010 6774 7163 5241 687 4193 PMC8764238__F3 Molecular Mechanism of Puerarin Against Diabetes and its Complications 3667 4193 2308 2932 581 PMC8771833__F5 Slit/Robo Signaling pathway in Bone Metabolism 9353 6091 998 5879 64221 1499 1000 PMC8774788__F5 Metformin Affects the Transcriptomic Profile of Chicken Ovarian Cancer Cells 10985 57379 8743 285 2172 2353 91543 4790 7083 3082 6774 4929 8174 4316 10397 PMC8777033__F3 Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites 2712 6120 7851 4118 11113 2752 7300 PMC8778593__F2 Therapeutic implications of exosomes in the treatment of radiation injury 7048 26524 7189 4851 4320 4312 PMC8782664__F1 LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring 929 4615 7099 7189 3661 7187 7098 51284 51311 54106 59272 57506 PMC8787203__F3 Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism 5236 9776 60673 PMC8787203__F5 Turning the Knobs: The Impact of Post-translational Modifications on Carbon Metabolism 54861 2597 7018 PMC8789681__F1 Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms 2316 6010 7046 4092 10533 7048 4087 4088 7178 PMC8794658__F8 Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis 100187907 351 114609 8567 7216 958 3492 PMC8796266__F1 Therapies for immune-related adverse events associated with immune checkpoint inhibition: from monoclonal antibodies to kinase inhibition 4067 695 3627 4283 6373 10344 10563 1977 613 2475 PMC8797156__F2 Research Progress on Leucine-Rich Alpha-2 Glycoprotein 1: A Review 8195 387 331 238 4087 PMC8797975__F5 Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease 324 64223 64798 2475 1977 5163 7249 7248 207 10000 5728 253260 387 5879 PMC8799876__F2 Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis 5340 3791 7018 PMC8801022__F2 Mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial disease 65018 596 139341 9776 PMC8804176__F2 Depression, Estrogens, and Neuroinflammation: A Preclinical Review of Ketamine Treatment for Mood Disorders in Women 10857 627 2852 7099 PMC8807838__F9 Promotion of the inflammatory response in mid colon of complement component 3 knockout mice 114548 1811 65010 55107 1080 718 4513 7124 PMC8808015__F1 Wnt Signaling Pathway and ROR2 Receptor in Embryonic Development: An Update Review Article 4919 4920 4040 4041 2932 324 771 23002 PMC8812184__F8 RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures 1956 2064 3265 6714 4824 367 5728 572 4193 2261 1029 1017 7018 5327 5328 596 2744 PMC8812204__F1 Dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke 6009 664 8408 9776 60673 22863 PMC8812204__F2 Dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke 8408 9776 5912 2475 9140 55054 9474 22863 7942 8878 4077 3916 3920 PMC8813987__F9 Pathway that signal prolonged cutaneous allodynia elicited by CGRP released and associated with neurogenic inflammation 7442 8989 10267 27035 PMC8814460__F2 Inflammation and Myeloid Cells in Cancer Progression and Metastasis 7157 6774 9021 383 6347 2919 3576 6374 2920 6352 284340 961 7852 6387 10344 6355 6354 3579 8205 PMC8815029__F1 Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications 9780 59341 387 847 PMC8817131__F3 PGC‐1A protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication 4899 1728 5442 PMC8818874__F5 Confirmation of inhibitingTLR4/MyD88/NFKB Signalling Pathway by Duhuo Jisheng Decoction on Osteoarthritis: A Network Pharmacology Approach-Integrated Experimental Study 4313 5599 240 595 841 598 1017 6774 572 891 581 1026 847 5594 3486 4609 6401 5327 1432 5111 7056 1277 1281 5602 54205 860 3627 6517 1019 3949 1147 4353 5579 5468 2152 9536 3099 239 3791 2353 332 890 6347 1543 2920 125 11200 2936 8972 PMC8829728__F3 Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation 3929 3553 3146 114548 79792 7099 PMC8830521__F4 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer 5728 4318 4313 6774 2475 114548 3553 581 5111 6125 PMC8830521__F5 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer 100124700 57721 581 7018 PMC8832963__F3 Emerging role of long noncoding RNA RMRP in cancer development and targeted therapy 693198 302 10413 3845 6023 894 6627 4193 PMC8833412__F1 New Insights on the Genetics of Pheochromocytoma and Paraganglioma and Its Clinical Implications 4191 1431 2271 3417 3418 6389 6392 54949 6390 6391 1743 54583 112398 7428 2260 10461 5979 1977 55654 4763 3265 4149 55534 317 7812 PMC8833440__F2 Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway 1901 9294 1903 6010 56848 8698 8877 PMC8833689__F2 Obscure Potential of AHNAK2 113146 2246 79026 57716 7018 5728 1499 999 PMC8834247__F3 Put in a “Ca2+ll” to Acute Myeloid Leukemia 355 84876 8772 472 2475 3418 581 3417 5371 25827 5728 22992 9927 PMC8834247__F4 Put in a “Ca2+ll” to Acute Myeloid Leukemia 6387 7852 3091 PMC8834450__F2 Punicic Acid and Its Role in the Prevention of Neurological Disorders: A Review 581 2475 10858 1020 348 PMC8835347__F7 Modulatory Effects of Alpha-Mangostin Mediated by SIRT1/3-FOXO3a Pathway in Oxidative Stress-Induced Neuronal Cells 6648 23411 847 581 PMC8835964__F8 Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer 11331 30968 9812 115209 4976 27102 581 578 1965 9451 10018 27113 5366 4170 468 22809 1649 PMC8837022__F3 Isoxazole Derivative of Usnic Acid Induces an ER Stress Response in Breast Cancer Cells That Leads to Paraptosis-like Cell Death 468 1998 7466 4508 22926 7186 6651 596 4397 100506742 100187907 6402 258010 10054 6500 9978 PMC8844459__F1 Application of Animal Models in Interpreting Dry Eye Disease 4280 7124 7808 PMC8845065__F6 Retinoic acid synthesis and signaling 10170 8854 220 1382 5915 216 5914 PMC8846368__F1 Targeting Nutrient Dependency in Cancer Treatment 435 445 440 4397 23657 2744 875 5226 2539 PMC8847441__F5 Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development 4851 3516 3280 388585 PMC8850794__F2 PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles 596 581 4303 5290 5728 387 2932 6387 3576 836 999 1000 1499 PMC8851036__F2 Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis 1311 7097 4353 7099 759 3383 7412 PMC8857760__F2 Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights 4615 3146 7100 PMC8860994__F8 Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence 7124 2534 8717 9846 7186 6010 6611 5163 5728 637 581 PMC8861501__F7 Integrative Analysis of the lncRNA-Associated ceRNA Regulatory Network Response to Hypoxia in Alveolar Type II Epithelial Cells of Tibetan Pigs 3458 3005 2023 5211 226 PMC8870128__F2 Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis 5226 5228 2853 PMC8874497__F2 Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer 50 948 3949 355 19 3156 55902 47 10400 PMC8876623__F1 mTOR Signaling and Potential Therapeutic Targeting in Meningioma 960 4771 100187761 5728 6009 7248 64798 64223 5163 PMC8877616__F1 Current and Emerging Medical Therapies in Pituitary Tumors 7045 4088 4089 4087 1813 5617 2475 1956 PMC8879554__F2 Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning 1738 1743 3419 8803 3418 50 4967 PMC8879755__F2 Innate Immunity in Mucopolysaccharide Diseases 7099 114548 7124 3553 2670 PMC8882979__F1 Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs 4920 4919 324 4040 4041 PMC8886606__F2 Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook 2549 3716 3718 929 114609 7189 4615 695 10010 8717 7186 PMC8888691__F5 Microglia and Astrocyte Function and Communication: What Do We Know in Humans? 4345 7096 7097 51311 10333 7100 54106 7099 7098 51284 3603 6347 6348 6352 6351 1232 1233 729230 1230 1234 PMC8888891__F2 Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity? 6662 2475 860 7494 1499 3725 2002 22926 64750 57154 51094 4772 7189 7186 PMC8889587__F6 Aberrant protein S-nitrosylation in ER stress-mediated insulin resistance 83939 468 1508 22926 100 PMC8891570__F1 Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease 9776 60673 9140 PMC8892093__F6 Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology 351 1020 23621 PMC8895820__F2 Molecular environment and atypical function: What do we know about enzymes associated with Mucopolysaccharidoses? 2588 2625 51363 PMC8897182__F2 Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension 4088 3949 7046 4035 5053 2717 659 PMC8898354__F3 Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases 3953 1786 23237 PMC8898355__F1 Ferroptosis by Amino Acid Metabolism in Cancer 100188776 875 9054 2242 2879 2475 PMC8899363__F3 Niban apoptosis regulator 1 promotes gemcitabine resistance by activating the focal adhesion kinase signaling pathway in bladder cancer 1845 3910 7018 2200 157869 1292 51429 4637 4638 4478 123720 29995 55742 5547 1293 1410 1809 3956 3678 5950 2161 3263 7052 335 3273 2162 2 1675 7145 4035 84617 4360 87 9332 975 10382 3987 2878 25959 6645 3483 8291 10979 4629 4928 8317 5936 29894 10713 6636 4171 9898 705 55720 4172 472 8833 23212 6472 23223 8495 54815 221613 1736 9100 10551 23246 637 8626 6714 7037 28998 53 1212 5511 80308 5373 581 29880 3694 2580 2059 5966 10952 6635 51729 81608 79711 55696 1997 PMC8899613__F8 Plasma Proteome Profiling of Patients With In-stent Restenosis by Tandem Mass Tag-Based Quantitative Proteomics Approach 4342 4023 347 7216 5360 1071 PMC8904278__F3 Metabolic Rewiring by NRF2 26227 29968 5723 2539 25796 7086 2879 2730 2729 2937 6510 23657 6520 PMC8905141__F5 Transcriptomic and Metabolomic Analyses Reveal the Differential Regulatory Mechanisms of Compound Material on the Responses of Brassica campestris to Saline and Alkaline Stresses 3242 47 2184 2271 6390 PMC8906930__F1 NRF2 in Bone Metabolism – Friend or Foe? 8452 9817 9978 4118 100 847 3162 PMC8907745__F1 Molecular Brakes of Adipose Tissue Lipolysis 50486 29923 5346 7038 5468 PMC8909279__F2 Nutrients against Glucocorticoid-Induced Muscle Atrophy 7249 2475 1977 1998 4088 4087 664 23710 PMC8909308__F4 Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection 3458 581 4703 3659 8651 2695 2353 831 4117 10379 2158 355 23673 5696 246751 PMC8911851__F6 Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics 50999 3320 23478 79188 23404 2166 8829 4763 57017 PMC8913803__F4 Signaling pathways and targeted therapy for myocardial infarction 5447 9817 387 6093 9475 4854 PMC8913803__F6 Signaling pathways and targeted therapy for myocardial infarction 688 4087 4088 4092 4089 55107 27123 4040 4041 324 2932 1499 PMC8914318__F7 New Vistas in microRNA Regulatory Interactome in Neuropathic Pain 7099 114609 4615 3656 3654 1847 51135 7189 10454 23118 7852 10628 114548 6935 3586 7186 2885 4087 4088 4092 4089 PMC8918930__F8 Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway 2771 2786 5566 391 5533 5515 2932 5436 6636 11338 10105 10262 9092 4116 9128 84844 596 8678 54948 5706 6143 9147 57471 PMC8924541__F4 Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats 7124 7038 5111 596 PMC8926997__F7 Mechanism and Function of miRNA in Intervertebral Disc Degeneration 8450 8451 10533 PMC8930095__F2 Talin-1 interaction network in cellular mechanotransduction (Review) 10395 2147 2152 387 PMC8931477__F1 Natural Products Against Renal Fibrosis via Modulation of SUMOylation 4089 6613 6612 1499 29843 26054 387082 3066 PMC8931538__F9 JAM-A–tetraspanin–AvB5 integrin complex regulates contact inhibition of locomotion 928 975 1445 5879 6714 10011 10006 PMC8932957__F2 Conserved nutrient-sensing response pathways in worms, flies and mammals 7942 207 3479 4609 1958 PMC8934861__F5 Analysis of Gene Expression Profiles in the Liver of Rats With Intrauterine Growth Retardation 2169 2168 2173 2167 335 2170 4023 5360 7350 4312 3611 7316 5163 364 PMC8935981__F7 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches 9869 5901 7341 5606 1432 4214 6300 5073 4117 545 472 PMC8935981__F9 Comprehensive Analysis of Prognostic and Genetic Signatures for General Transcription Factor III (GTF3) in Clinical Colorectal Cancer Patients Using Bioinformatics Approaches 3240 2099 22937 2194 6319 1390 31 PMC8943601__F1 Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases 3667 572 2475 PMC8944338__F3 Protein-protein interaction network for the AGE-RAGE pathway 183 7043 7042 185 7040 7048 10000 207 7124 3383 4313 2277 1906 5054 7424 2152 3569 7056 7412 6401 3552 3553 6347 1277 595 5295 8503 7423 1278 7422 5599 5291 5602 6772 6774 6300 5293 208 5292 3717 5600 5601 5290 5594 5603 5296 4790 5970 4772 836 5595 1432 5332 5333 177 596 27035 5579 581 3845 50507 5335 113026 51196 1536 1729 5578 998 1958 4088 5879 3265 4089 7046 4087 5590 5580 5581 PMC8945343__F4 Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies 664 4976 847 7351 55669 9927 PMC8945922__F5 Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components 5728 83939 468 64422 8660 22863 6009 7249 2475 9776 57103 PMC8946840__F2 Mesothelin: An Immunotherapeutic Target beyond Solid Tumors 10232 572 581 94025 23678 2309 22943 6774 1017 PMC8946903__F12 Spermatozoal Mitochondrial Dynamics Markers and Other Functionality-Related Signaling Molecules Exert Circadian-like Response to Repeated Stress of Whole Organism 5071 65018 4899 4976 51024 5467 7019 7942 9927 7351 10891 114 5599 5601 5598 5594 1432 133522 111 5603 5595 6300 5597 7352 5465 7350 5577 5573 5576 5566 5600 PMC8947539__F1 Aging of the Immune System: Focus on Natural Killer Cells Phenotype and Functions 4277 100507436 5551 84876 PMC8948217__F5 Notch signaling pathway: architecture, disease, and therapeutics 2625 50943 8320 3002 6374 6347 8205 PMC8949198__F1 Oxidative Stress in Arterial Hypertension (HTN): The Nuclear Factor Erythroid Factor 2-Related Factor 2 (Nrf2) Pathway, Implications and Future Perspectives 9817 4094 847 64122 PMC8955937__F9 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders 3091 3099 3939 5163 1431 PMC8955937__F10 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders 3091 51741 3099 3939 5163 1431 PMC8955937__F11 WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders 3091 51741 3099 3939 5163 PMC8958363__F7 Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages 22926 1643 7494 468 51726 4189 3309 64714 7184 2923 1869 84126 545 2177 675 5888 10111 10484 11253 23193 56886 10945 8615 8702 PMC8960436__F3 Celastrol Alleviates Autoimmune Hepatitis Through the PI3K/AKT Signaling Pathway Based on Network Pharmacology and Experiments 2908 5294 5465 9971 10062 5468 5743 5781 5894 5265 6648 7422 6772 4846 6850 7010 4609 7040 4318 3932 3717 4314 7042 7046 7076 7276 6714 7454 5594 207 3265 5295 34 3702 308 581 3643 598 3558 695 3479 3320 834 3162 836 595 2885 2321 2260 2147 2099 1991 1956 1559 1588 1118 8837 PMC8960856__F4 MicroRNAs in Serum Exosomes as Circulating Biomarkers for Postmenopausal Osteoporosis 9350 50964 7454 25805 2040 6259 27130 324 387 9475 6500 25776 4089 4088 51701 PMC8960923__F1 Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer 22926 2475 2078 PMC8961181__F1 Genetics, Breeding and Genetic Engineering to Improve Cottonseed Oil and Protein: A Review 355 5091 4018 4026 PMC8961894__F1 DNA in extracellular vesicles: from evolution to its current application in health and disease 967 928 975 11031 4827 PMC8963304__F8 Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons 1909 1910 3265 2885 5159 5879 185 3690 4851 50507 10454 1601 3688 3685 331 4792 7114 1655 1499 23462 5728 999 1003 59 6667 595 4312 406909 100302188 947 1017 1019 5741 7077 7076 3082 2247 7422 PMC8965109__F9 Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma 64682 5591 7029 699 4090 657 91 4089 93 6667 10274 5933 8243 7398 5885 10111 9126 9765 9372 11073 2033 1017 10735 1387 10499 1027 83990 6093 9968 8202 4683 5291 9969 23389 5781 2956 57678 1499 5290 867 5286 331 8453 9821 3915 23365 317 26060 9475 6654 PMC8965611__F5 Signaling Pathways Associated With Breast Cancer Bone Metastasis 1499 26281 8817 4609 4040 7189 6714 3725 4088 4286 2475 PMC8966389__F3 Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved 3661 57506 29110 3454 3455 7297 6772 10379 3716 6773 891 983 PMC8977492__F2 Adenosine-A2A Receptor Pathway in Cancer Immunotherapy 952 3091 100 84890 3586 PMC8978805__F2 Impact of anti-inflammatory agents on oncogenic pathways 6387 1786 1789 7852 80312 2475 6774 4512 4513 1385 10413 100653366 2932 3977 4170 57650 4609 29072 3594 64109 85480 2146 54790 PMC8995861__F3 Oxidative RNA Damage in the Pathogenesis and Treatment of Type 2 Diabetes 11164 79873 55270 PMC8995973__F2 Pyroptosis by ncRNA: A Novel Research Direction 22861 147945 114548 9447 79792 1687 3002 55876 3001 7124 56169 PMC8997790__F3 Vitamin D and Hypoxia: Points of Interplay in Cancer 1263 7421 5728 54541 5163 7249 7248 6009 1977 3091 2034 PMC8998661__F2 Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders 4018 6722 4040 387 6093 1758 22943 4041 1499 9242 PMC8998691__F3 MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway 4803 4908 4915 4916 57498 25 6464 399694 3667 5336 5335 1398 1399 2885 2549 5663 7189 998 5879 8767 3654 5781 5290 7531 805 4214 3845 397 816 673 7161 387 4215 10000 7157 3725 5607 5604 572 581 5970 4792 9261 6197 356 596 PMC8999052__F6 Wide-Proteome Analysis to Identify Molecular Pathways Involved in Kidney Response to High-Fat Diet in Mice 6748 2653 8848 4133 5604 3315 3921 6418 5836 7532 51380 PMC9000186__F7 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury 8877 3486 56848 7124 PMC9000186__F8 Rheostat of Ceramide and Sphingosine-1-Phosphate as a Determinant of Oxidative Stress-Mediated Kidney Injury 56848 8877 7124 3553 PMC9004567__F5 Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine 1147 5494 1101 3702 4609 3630 80853 6387 2475 6696 3685 5747 3082 3479 7150 1616 3716 PMC9006951__F2 Alzheimer’s Disease: An Update and Insights Into Pathophysiology 5340 4318 4314 10063 392862 2670 PMC9008121__F2 Targeting non-coding RNAs to overcome cancer therapy resistance 102723932 2627 29931 4904 22931 399959 23130 27161 7150 7153 4144 10721 5591 5728 558 101805488 9212 100126326 23657 7157 1311 3627 PMC9008778__F5 Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C 5091 324 142 7248 7249 3098 114548 3553 PMC9010225__F2 Emerging role of PARP-1 and PARthanatos in ischemic stroke 7226 4282 8505 PMC9010858__F2 Treatment of Retinoblastoma: What Is the Latest and What Is the Future 1869 4613 914 PMC9011113__F3 Myth of cobra venom cytotoxin: More than just direct cytolytic actions 836 355 50507 1386 2022 3326 PMC9011221__F3 Critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review 2937 23657 2879 468 467 8678 8314 3309 PMC9015857__F10 Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis 6850 5594 27040 2885 5335 PMC9023181__F4 Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets 3725 142 7137 248 1351 1349 1350 1347 805 1376 4708 1666 1649 4700 10449 9997 3033 6513 6390 4729 6342 4722 4698 5571 7419 7124 7417 292 PMC9023792__F2 Emerging Role of Hedgehog Signaling in Viral Infections 5727 6608 2121 2736 2737 2735 PMC9024123__F4 Network Pharmacology Analysis of Huangqi Jianzhong Tang Targets in Gastric Cancer 7153 3553 8202 595 5578 7040 5728 5328 6256 2944 5290 1026 842 7157 4318 5925 4609 7099 836 999 5111 4524 5743 1956 3162 3274 4313 2475 332 10413 1499 6667 54205 1950 598 3091 5599 841 6648 5243 596 5595 2353 2064 581 1017 6513 4780 7422 2932 2099 2950 3480 5594 887 207 2520 3265 3845 3725 2100 PMC9026172__F5 Pharmacodynamics, Network Pharmacology, and Pharmacokinetics of Chinese Medicine Formula 9002A in the Treatment of Alzheimer’s Disease 100196919 7124 3065 6915 2912 1636 8698 1508 9429 836 43 5243 2100 5319 998 4985 1268 367 3356 9294 5468 1511 2908 846 4843 7067 5465 1557 54106 3320 351 1559 5743 1786 1457 3383 9536 196 4846 3066 6532 597 5915 7150 1269 4129 5737 2099 6256 5770 5914 5970 5788 1544 23411 4311 1129 8841 2833 2904 1586 1128 7015 4988 5602 1588 842 152 PMC9026965__F1 Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health 1431 3569 65018 55288 51024 55669 23411 7421 2475 PMC9030480__F2 Translational Strategies to Target Metastatic Bone Disease 6347 445347 5741 PMC9032101__F1 Importance of Endoplasmic Reticulum Stress as a Novel Antidepressant Drug Target and Its Potential Impact on CNS Disorders 627 9695 22926 1998 468 PMC9034286__F6 Monitoring the induction of ferroptosis following dissociation in human embryonic stem cells 6010 23657 2879 PMC9040670__F8 Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens 83939 468 440 9965 355 PMC9059429__F1 Rodent Genetic Models of Ah Receptor Signaling 196 405 57491 1545 PMC9063434__F2 Metallodrugs: an approach against invasion and metastasis in cancer treatment 355 4199 6935 9839 PMC9068331__F2 Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability 9865 6009 3815 5728 64798 6010 PMC9069003__F3 Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2 59272 3553 4094 847 9817 114548 PMC9069003__F4 Action of Ozone Therapy in Emerging Viral Diseases: Immunomodulatory Effects and Therapeutic Advantages With Reference to SARS-CoV-2 59272 3553 9817 3091 405 114548 PMC9072795__F1 Molecular signaling in temporomandibular joint osteoarthritis 1499 51083 2618 4322 9507 11096 4088 3549 6608 2260 2261 9968 2736 2737 102 PMC9091963__F8 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System 1499 4513 1636 PMC9093608__F7 Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions 5621 427 137970 219699 84894 85358 9378 54806 759 9049 176 1794 2064 57628 PMC9097137__F2 Current Insights Into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape 2581 6647 4155 10215 PMC9097270__F6 DNA repair, recombination, and damage signaling 10419 596 317 4738 348654 5888 4438 PMC9099524__F2 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer 3553 6774 4513 3845 PMC9099959__F3 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology 196 5053 405 672 7189 1543 1544 PMC9099959__F4 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology 472 545 196 672 PMC9099959__F5 Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology 196 8717 7186 4615 3654 51135 7189 23118 257397 7334 3665 51284 PMC9101486__F6 High-Fat Diet Induces Low-Grade Cochlear Inflammation in CD-1 Mice 4615 7189 23118 257397 7186 3569 7412 3383 PMC9102069__F2 Immunogenic Cell Death, DAMPs and Prothymosin A as a Putative Anticancer Immune Response Biomarker 197259 637 581 PMC9102406__F3 Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System 10392 1956 9817 6647 6648 196 1543 PMC9104445__F8 Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway 4803 4316 4318 PMC9104602__F5 ZIKV infection downregulates host mRNA expression in the placenta, including genes associated with cellular function and development 221662 5450 5274 3781 55024 4261 6900 10874 64211 54346 136263 680 4356 5915 2918 8825 575 2696 58530 1952 576 79611 6531 51760 6999 361 3538 3500 56034 3175 325 944 10215 204962 7781 143425 135935 9118 22987 6857 627 1149 9479 7124 974 5460 6656 390598 4948 5923 10716 8741 4314 5080 3667 1906 383 4914 387104 388389 7057 23682 4760 5320 83714 8366 90624 50801 7130 4256 2919 2056 201501 6493 139628 PMC9104724__F4 Yeast as a Model to Find New Drugs and Drug Targets for VPS13-Dependent Neurodegenerative Diseases 5955 10993 1255 PMC9106463__F3 PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function 596 8452 581 PMC9114637__F1 Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis 59341 176 9780 3554 PMC9114642__F1 Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury 83939 468 596 581 7186 PMC9114642__F2 Endoplasmic Reticulum Stress and the Unfolded Protein Response in Cerebral Ischemia/Reperfusion Injury 22926 83939 468 581 7186 PMC9115588__F5 Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities 4040 4041 2932 1499 595 6774 2534 999 PMC9116919__F2 Vascular Calcification in Chronic Kidney Disease: An Update and Perspective 5741 5745 6774 860 6662 4488 7099 4615 1499 23411 4041 8473 2475 PMC9117765__F2 TEAD4 as an Oncogene and a Mitochondrial Modulator 6010 1499 4088 60485 4485 9113 26524 7004 4771 864 2475 PMC9120423__F1 Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review 100188857 107966124 920 100187761 PMC9120625__AF1 Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression 5925 627 2932 1499 PMC9120625__F6 Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression 5925 627 2932 1499 PMC9120690__F1 Targeting O-GlcNAcylation in ischemic stroke 7494 64841 5238 10724 PMC9120845__F1 Aberrations in the Cross-Talks Among Redox, Nuclear FactorKB, and Wnt/Beta-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome 5308 3146 5971 8772 83439 607 6500 177 7850 929 51176 2033 4792 7186 7097 3588 8313 22943 7099 7133 83999 6356 1499 1437 3586 284654 3587 4041 4040 1495 1991 1956 3932 1401 1234 4160 5443 213 729230 1001 7082 969 8826 2064 100506658 3240 4069 930 4986 952 375790 972 975 915 3122 2876 2217 59272 3039 340024 PMC9121204__F1 Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management (Review) 11035 197259 8717 8772 4666 581 2056 6774 2475 PMC9124149__F1 Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope 51024 4282 55669 9927 PMC9133627__F1 Advances on Innate Immune Evasion by Avian Immunosuppressive Viruses 7187 57506 3665 115004 7297 3455 6773 10379 PMC9136572__F2 Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases 1581 9965 1582 1593 5465 29881 8213 7436 3949 348 7038 25801 5360 27329 355 3170 3643 PMC9140926__F10 Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NFKB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells 3550 3553 4513 PMC9142883__F7 Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer’s Disease in APP/PS1 Transgenic Mice 110231149 1506 1504 4666 7462 PMC9143262__F4 Platelet-Derived Growth Factor Pathway in Pulmonary Arterial Hypertension: Still an Interesting Target? 759 846 6772 6774 4303 595 6786 84876 2475 PMC9146859__F2 Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals 10269 2100 4312 116519 3949 5469 9023 3156 19 335 949 PMC9152764__F1 High Intensity Interval Training: A Potential Method for Treating Sarcopenia 6009 1977 6194 1975 1938 23411 7019 PMC9157596__F4 Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes 5562 8503 5295 5293 113 5571 109 847 112 107 5290 196883 208 5296 2475 115 108 3643 3667 5564 5565 6199 51422 5563 64764 2308 1385 57521 10488 2309 51094 1386 7248 581 79602 5468 10919 6009 1978 6794 9365 1977 27244 83667 1388 143686 9821 814 468 5567 5566 3265 7157 26060 3845 PMC9159819__F1 Neurobiological Links between Stress, Brain Injury, and Disease 2475 627 581 83939 468 1325 PMC9159919__F7 Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/Beta-Catenin Signaling Pathway 324 54101 50964 999 2919 1499 PMC9162355__F10 1,2,3,6-Tetra-O-galoyl-Beta-D-glucose induced apoptosis signalling pathway in SGC7901 cells 317 581 472 PMC9166240__F8 Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy 3717 6774 4615 PMC9166453__F2 Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases 637 581 6722 998 1386 6010 2475 PMC9166517__F8 Network Pharmacology-Based Strategy Combined with Molecular Docking and in vitro Validation Study to Explore the Underlying Mechanism of Huo Luo Xiao Ling Dan in Treating Atherosclerosis 1950 355 929 2885 7124 8717 130589 7186 1616 51295 1610 2645 3240 2316 4351 51701 3727 4149 6722 PMC9166893__F8 Essential role of CK2A for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint 1017 8317 8318 63967 84126 545 3014 4172 4174 4173 4176 4175 4171 PMC9168372__F2 Anti-Inflammatory Activities of Betulinic Acid: A Review 3383 7412 7124 PMC9169354__F2 Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer 122786 4485 60485 9113 154796 374 4609 2246 3397 PMC9170610__F3 Calcineurin in development and disease 7225 3690 5879 998 PMC9172006__F3 TMEM16A as a potential treatment target for head and neck cancer 1950 6714 6774 1956 PMC9174948__F3 Chloroplast pH Homeostasis for the Regulation of Photosynthesis 586 4519 587 PMC9179555__F4 Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease 5163 7249 2475 PMC9181281__F10 Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NFKB Signaling 7099 4513 3569 PMC9181425__F4 Thirty Years’ History since the Discovery of Pax6: From Central Nervous System Development to Neurodevelopmental Disorders 894 5080 63973 6657 3280 388585 5978 63951 1000 1826 11178 10716 23316 PMC9188076__F5 Pharmacological mechanisms of sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction 367 5091 100187761 PMC9189267__F3 Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19 3554 114548 3146 79792 9447 57506 537 PMC9196267__F3 Focusing on Formononetin: Recent Perspectives for its Neuroprotective Potentials 2932 351 102 7099 4094 9817 581 847 PMC9197233__F5 Mechanical Strain Induces Transcriptomic Reprogramming of Saphenous Vein Progenitors 998 6416 54778 4087 4088 2885 7030 7421 4133 5604 4838 3665 145258 596 268 23090 4090 4086 3196 3225 5308 PMC9197867__F2 Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases 7422 7423 5266 4512 PMC9200584__F3 Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis 3791 1432 2353 4843 5595 4170 3458 3320 331 7157 1147 5578 6373 3576 6401 4792 4318 596 5970 3725 6696 6347 1956 5743 4609 1950 1281 3162 7422 836 2920 598 4846 3627 4314 5328 842 3551 114548 7124 PMC9201060__F1 Anti-Müllerian Hormone Signal Transduction involved in Müllerian Duct Regression 268 7018 269 7054 4089 4090 4086 PMC9202500__F4 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses 2475 8408 9474 3480 PMC9204157__F6 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis 2475 3480 7249 7248 6885 51083 6010 29110 PMC9205467__F1 Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges 100 2936 6520 23657 2937 2879 999 4771 2182 7018 3658 9817 PMC9206211__F2 Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis-Induced ALI/ARDS: New Research Progress and Prospect 6774 3717 383 2475 26291 23411 9242 PMC9213757__F1 Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways 55183 26013 165918 4361 672 580 56916 PMC9218606__F4 Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress 246751 2729 1728 6647 9817 8452 PMC9220294__F8 Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration 7099 4615 3146 2815 PMC9221178__F2 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression 7099 114609 4615 3654 51135 7189 23118 10454 7098 3553 324 PMC9221178__F4 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression 7099 114609 4615 3654 51135 7189 23118 10454 324 7098 PMC9221329__F1 Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review 9839 1000 999 1499 6774 7124 4322 PMC9221492__F1 Synthetic Vulnerabilities in the KRAS Pathway 4485 2885 11186 5900 6010 3845 10928 7074 2475 382 998 PMC9228484__F2 Virus–Host Interplay in Junín Mammarenavirus Infection 3615 10146 375 7251 27183 9525 PMC9234286__F1 Insight Into Rho Kinase Isoforms in Obesity and Energy Homeostasis 387 6722 26291 3717 PMC9235413__F2 Wnt signaling in mechanotransduction and extracellular matrix (ECM) alterations in uterine fibrosis 2932 324 1499 4040 4041 999 PMC9236130__F1 Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer 6010 6722 4018 4099 100379198 PMC9238352__F3 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways 3929 3952 7939 7097 929 10333 54472 114609 4609 54106 7098 1513 5879 5966 8772 4615 5132 23118 51135 3661 256933 7124 958 942 PMC9238352__F5 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways 9365 1616 5978 1610 4351 3142 4280 4149 8405 PMC9238352__F7 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways 3458 1956 920 3932 114609 5728 7189 27040 7535 10538 3725 PMC9243368__F1 Advancements in prevention and intervention of sensorineural hearing loss 3714 3280 388585 474 2932 1499 PMC9244849__F4 Disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain 613 930 6850 5879 951 7248 7249 6009 572 4193 672 5934 150365 1975 PMC9247141__F1 Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis 7018 55240 2512 6520 23657 2495 4015 10499 2879 10162 2182 PMC9248048__F3 Footprint of Kynurenine Pathway in Cardiovascular Diseases 338 3156 196 2919 PMC9250978__F1 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways 1636 55601 51428 4361 115004 3661 3428 9447 1660 29110 PMC9252571__F1 Metabolic pathways implicated in ferroptosis 9817 7018 55240 23516 2879 8031 154214 PMC9253751__F9 Pre‐ and post‐conditioning with poly I:C exerts neuroprotective effect against cerebral ischemia injury in animal models: A systematic review and meta‐analysis 54106 7189 3665 100187907 4615 51135 29110 3661 7124 PMC9253771__F3 Combinatorial CRISPR Interference Library for Enhancing 2,3-BDO Production and Elucidating Key Genes in Cyanobacteria 7216 57762 717 PMC9260753__F6 Network Pharmacology Experiments Show That Emodin Can Exert a Protective Effect on MCAO Rats by Regulating Hif-1A/VEGF-A Signaling 2950 8767 412 11156 5243 7498 1544 377677 9212 3791 4128 1956 2064 7376 240 1565 196 11238 4129 5970 7124 847 2100 64816 8824 79068 1571 1576 1814 2194 54106 3932 23632 590 9429 3939 3945 1021 1551 765 1577 4282 558 80351 596 1545 PMC9263770__F9 Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice 3553 3663 3569 7124 3586 PMC9267007__F1 Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair 6774 2057 2056 5163 613 1499 581 PMC9267017__F1 Novel Drugs with High Efficacy against Tumor Angiogenesis 2534 998 6010 1499 1003 PMC9268608__F11 Stereoselective Binding of Trans-(±)-Kusunokinin and Cis-(±)-Kusunokinin Isomers to CSF1R 6774 3718 1435 595 146433 993 1436 1950 1956 1017 4513 231 PMC9271452__F3 Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy 91942 51069 26517 56993 4580 1356 140805 PMC9271889__F5 Autophagy in health and disease: From molecular mechanisms to therapeutic target 8408 9140 440026 59272 55054 55014 9342 PMC9271918__F2 Molecular Mechanisms of Plant Responses to Salt Stress 578 51411 54861 PMC9272348__F3 Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease 6647 6648 847 43 PMC9274484__F3 Gut microbiome in gastrointestinal cancer: a friend or foe? 10663 58191 7099 4615 4049 4513 PMC9274484__F4 Gut microbiome in gastrointestinal cancer: a friend or foe? 999 7099 1499 4615 7124 7097 8161 201633 PMC9277720__F2 Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers 3716 3717 3718 6774 6772 9021 7124 7186 PMC9278000__F2 Recent clinical findings on the role of kinase inhibitors in COVID-19 management 59272 695 114548 3553 PMC9281180__F3 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases 440823 79792 10628 114548 6120 7416 6647 56339 5728 PMC9283012__F3 Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 and Its Related Molecules as Potential Biomarkers in Small-Cell Lung Cancer 10645 1649 83452 7048 627 7879 10746 151 483 5515 10105 6197 8897 5922 9254 6546 5581 5997 58476 5516 664 1910 3920 5971 150 7786 6788 9706 2122 64121 54541 5140 785 23118 152 1508 2147 4208 1909 2254 7054 26281 8976 7124 10451 387 4929 10163 10501 4040 1073 2042 2050 1730 3676 6092 10371 8396 7430 1808 6259 2534 2043 PMC9290708__F3 Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis 1581 2264 152831 9965 PMC9293612__F2 Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma 6387 6359 6347 7852 729230 6774 8205 619501 140885 961 100133941 6364 1235 6361 PMC9293722__F6 Retinoic acid can improve autophagy through depression of the PI3K-Akt-mTOR signaling pathway via RARA to restore spermatogenesis in cryptorchid infertile rats 5914 7054 346673 50511 PMC9297598__F11 Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages 7124 6351 1316 9242 6774 383 PMC9297685__F4 Possible mechanisms of cardioprotection resulting from stimulation of insulin receptor family members 3481 8408 3479 115004 PMC9299562__F3 Integrated bioinformatics analysis of validated and circulating miRNAs in ovarian cancer 5447 1674 847 8213 PMC9301111__F2 Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant 2597 6477 4204 7249 6009 627 3084 2066 29904 1938 PMC9302318__F6 Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome 7124 1950 355 929 2885 8717 7186 1616 23118 51295 5901 3240 2316 4351 51701 2002 3727 4149 6722 PMC9302318__F7 Network pharmacology analysis of molecular targets and related mechanisms of Guizhi decoction in treating of menopausal syndrome 613 6850 930 2885 5879 5728 951 7249 2475 572 4193 6009 51083 672 4609 5934 1537 PMC9304404__F7 Mechanistic diagram of apatinib in NSCLC cells 6510 440 468 PMC9305279__F1 Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19 8408 59272 9140 7942 PMC9305279__F2 Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19 8408 9140 440026 81671 59272 23339 55823 55014 9342 8673 PMC9307349__F2 Active Compounds and Targets of Yuanzhi Powder in Treating Alzheimer's Disease and Its Relationship with Immune Infiltration Based on HPLC Fingerprint and Network Pharmacology 6416 4792 10769 5925 5604 6507 3693 10381 6622 2697 3685 2911 116 3570 2353 2890 6347 8900 6696 7124 2752 1128 596 2566 2558 2554 2152 PMC9311581__F2 Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress 9817 5728 1950 124222 10072 672 3842 5971 5970 7124 PMC9311581__F3 Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress 3099 2597 3939 2539 5315 7086 26227 5226 948 29968 2806 355 4199 6472 6120 6478 4967 6510 PMC9314331__F5 S6K functions in feedback regulation 5163 3667 7249 7248 2932 3065 PMC9315613__F3 Phytochemicals as Regulators of Tumor Glycolysis and Hypoxia Signaling Pathways: Evidence from In Vitro Studies 5728 2475 4193 3240 PMC9315706__F1 Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target 664 8408 596 60673 7405 55626 10533 64422 9140 PMC9315706__F5 Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target 55626 8408 60673 9100 8975 9706 PMC9315891__F2 Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues 7498 4018 355 95 PMC9315891__F3 Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues 7498 7504 6120 PMC9316483__F2 Study on the Molecular Mechanism of High Altitude Heart Disease in Children 2033 55662 5465 51129 5728 1909 54583 PMC9316959__F4 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma 387 998 5879 1499 607 4087 4088 4089 1956 6868 4609 2621 558 PMC9317282__F12 Comparative Transcriptome and Interaction Protein Analysis Reveals the Mechanism of IbMPK3-Overexpressing Transgenic Sweet Potato Response to Low-Temperature Stress 7018 2077 4602 4609 PMC9320762__F1 Non-Canonical Programmed Cell Death in Colon Cancer 995 983 472 993 1017 6741 545 PMC9322149__F4 Exploring Quercetin Anti-Osteoporosis Pharmacological Mechanisms with In Silico and In Vivo Models 7124 8717 7186 8772 83737 759 3976 1896 6401 1990 PMC9322956__F1 Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century 3667 3717 6774 2885 2064 2065 6714 PMC9323637__F3 Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy 10891 4853 3157 3156 6010 382 9230 PMC9327246__F8 d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model 283871 581 1017 1021 PMC9330218__F3 Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer 2475 367 23411 22926 84839 10682 1950 22937 47 6319 2194 3949 3156 PMC9332234__F1 Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease 9817 8452 9978 PMC9333241__F8 Mapping of gene expression change on Na/K-ATPase/Src signaling pathway 6697 2534 53358 54205 1537 1398 847 50964 5062 4117 PMC9334851__F1 Cross-Activation of Hemichannels/Gap Junctions and Immunoglobulin-Like Domains in Innate–Adaptive Immune Responses 24145 79827 220296 969 958 613 4179 942 920 930 940 961 373073 PMC9336466__F2 Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues 8772 5966 23118 4478 5817 27040 PMC9337250__F4 Bile acids and sphingolipids in non-alcoholic fatty liver disease 1901 5163 9294 8698 6010 5728 PMC9343736__F3 Endothelial cells in vascular calcification 3606 4087 4088 650 860 652 4089 654 6657 655 4256 PMC9344092__F2 Phagocytic microglia and macrophages in brain injury and repair 3566 6778 90865 383 6761 948 PMC9348619__F6 Differentially Active and Conserved Neural Enhancers Define Two Forms of Adaptive Noncoding Evolution in Humans 9350 6423 25960 374946 2719 2776 1454 6789 1654 51527 1499 2932 5663 324 5516 6477 6907 6500 51704 9679 2889 83595 6659 9314 79960 8629 1488 7090 7091 26108 51366 283149 51701 6885 4609 5467 PMC9354928__F2 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma 5728 2475 7249 7248 6009 5163 PMC9354928__F3 Research Progress on the Regulation Mechanism of Key Signal Pathways Affecting the Prognosis of Glioma 3091 6009 64223 1977 9776 8408 9706 PMC9355403__F8 Of ATP5MG to Treat Metabolic Syndrome-Associated Cardiovascular Diseases 9377 10632 4714 6647 4191 PMC9355713__F3 Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism 847 9817 468 114548 PMC9361782__F7 Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma 5948 5950 116362 5947 157506 5959 10170 9249 10901 51109 2171 216 8854 220 64577 1382 56603 5914 5915 595 2697 7157 7832 7422 842 PMC9365022__F5 Doxorubicin-Induced Cardiotoxicity May Be Alleviated by Bone Marrow Mesenchymal Stem Cell-Derived Exosomal lncRNA via Inhibiting Inflammation 126669 4703 149998 3136 472 6955 64065 2717 PMC9367915__F1 Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer 84126 545 11073 7465 983 472 675 672 207 6789 6788 4485 9113 26524 2078 2115 5728 100188776 4609 PMC9368800__F1 Delivery of Nucleotide Sugars to the Mammalian Golgi: A Very Well (un)Explained Story 10559 55343 84912 23443 488 7355 51463 PMC9370431__F4 Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action 847 7412 3383 3553 PMC9370431__F5 Effect of Laminaria japonica on Metabolic Syndrome: A Systematic Review of Its Efficacy and Mechanism of Action 847 4023 3931 355 PMC9371632__F2 Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection 7297 10379 7187 59272 7098 3661 3665 51284 4615 7189 57506 7186 29110 3569 115004 PMC9372561__F1 Gut microbiota dysbiosis: The potential mechanisms by which alcohol disrupts gut and brain functions 3553 324 7099 PMC9372913__F8 WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro 4040 4041 324 6929 6925 1499 9620 7089 7091 6010 144165 1386 5879 3725 960 2475 PMC9374760__F1 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways 57162 57161 246330 81858 90268 1540 3929 5970 5971 108348016 929 7099 602 4118 11213 54472 4615 51135 3654 3656 7189 8737 7185 8772 29110 7187 841 10010 51295 257397 23118 10454 2005 2002 2353 2000 3663 3665 3725 3661 10379 6773 6772 6774 PMC9374760__F2 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways 611 23533 5295 6714 9844 394 6376 7852 5290 2775 2768 10672 1794 998 6387 9294 1901 5291 9138 2776 5294 387 57580 5996 5997 9628 8787 6002 3635 5728 83478 PMC9374760__F3 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways 7096 388325 7097 5300 83737 26994 10333 4118 5970 108348016 7098 1540 90268 602 3929 929 54472 6761 7185 57161 246330 81858 7100 23118 51295 10010 8737 8772 81030 11035 197259 2005 2353 466 1053 1051 468 2000 1050 3665 3725 3661 4286 4773 4088 6722 6773 4087 6774 6667 9447 6352 6348 6346 6351 6347 6364 6359 6356 6362 6361 6363 1440 1437 356 3592 59067 3596 50604 3600 3606 29949 11009 9235 4254 27179 4049 3976 7043 7040 7042 7124 199713 81793 1660 57506 7186 338321 619410 7297 4671 834 51320 79594 22954 11074 84675 7706 115004 3440 3439 3441 3447 3448 3446 338376 3451 3458 56832 282617 101180976 282618 163702 171389 PMC9374760__F4 Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways 5578 200576 9564 1398 824 28964 826 1796 5829 83706 5091 5337 55022 3611 3702 611 3635 5290 5291 5294 5295 23533 5728 5170 5590 5747 4535 2185 324 1794 9844 9138 9181 50649 56288 9459 57580 8874 1793 10152 3426 7430 2934 1729 81624 10458 55845 55740 10787 6376 6387 2775 2768 10672 6197 7852 1445 2534 6714 7114 9294 1901 7414 7454 6548 8936 10163 7791 998 387 5594 5599 5604 6416 4214 4638 2776 394 83478 2889 10235 572 596 1499 2002 2309 3725 5996 5997 9628 8787 6002 673 2885 653361 4790 5970 PMC9376100__F4 Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) 2946 8837 7128 355 PMC9376100__F6 Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) 729230 1234 3590 6774 5008 4088 4087 4089 6010 2475 1499 PMC9379408__F10 Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells 6667 6670 80772 PMC9379413__F3 Phase separation in Cancer: From the Impacts and Mechanisms to Treatment potentials 1499 324 5469 23476 9113 2885 4485 51339 PMC9380940__F3 Causal network predicted for STAT3 regulator showing its relationship with obesity and inflammatory response, obtained using Ingenuity Pathway Analysis (IPA) 5443 6774 1030 PMC9384889__F7 Molecular Mechanism of Xingnao Kaiqiao Pill for Perioperative Neurocognitive Disorder and Its Correlation With Immune and Inflammatory Signaling Pathways Based on Network Pharmacology and Molecular Docking 7124 7186 197259 8772 83737 771 100187907 64127 3726 PMC9384889__F8 Molecular Mechanism of Xingnao Kaiqiao Pill for Perioperative Neurocognitive Disorder and Its Correlation With Immune and Inflammatory Signaling Pathways Based on Network Pharmacology and Molecular Docking 920 550641 5966 100187907 3934 PMC9385341__F2 From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease 6520 2879 10162 4015 8031 PMC9393262__F1 Th2A cells: The pathogenic players in allergic diseases 324 920 7535 4512 6761 90865 3556 4615 7189 PMC9393754__F4 Hypoxia-inducible factor-1 alpha in multidrug-resistant breast cancer 637 1499 9474 PMC9396495__F2 Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma 717 1508 1519 4050 4018 PMC9396537__F1 Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming 2475 948 95 622 23411 5465 23410 PMC9399075__F1 Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease 56848 8877 6611 253782 29956 204219 10715 79603 91012 2531 7357 64781 PMC9399422__F6 Identifying gene variants underlying the pathogenesis of diabetic retinopathy based on integrated genomic and transcriptomic analysis of clinical extreme phenotypes 23316 57569 352966 3553 4162 9828 5097 9883 100101267 650 27031 29940 440107 22837 132884 23216 338773 151258 56914 9060 PMC9402792__F5 MRNA–miRNA–lncRNA Regulatory Network and Factors Associated with Prognosis Prediction of Hepatocellular Carcinoma 1956 11221 23479 388 4082 8434 133746 5465 4478 28987 29126 5315 PMC9402976__F2 Review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer 5163 4067 867 3717 2885 6774 PMC9404373__F1 Metabolomics in rheumatoid arthritis: Advances and review 3099 5091 5132 4015 4318 3553 6774 2263 PMC9405302__F5 Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants 9817 324 4199 2539 1493 3417 84890 PMC9405369__F1 Clinical Research Progress of Small Molecule Compounds Targeting Nrf2 for Treating Inflammation-Related Diseases 9817 4094 1728 3162 2730 PMC9406056__F1 Neurotransmitters: Potential Targets in Glioblastoma 1956 5728 51083 4852 PMC9406090__F2 Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge 29102 79727 389421 23318 79670 129563 PMC9406569__F4 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers 6009 7248 7249 2475 7030 7189 7942 1513 PMC9406569__F6 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers 7046 1513 4615 114609 10131 4089 929 5901 3394 4088 116986 6774 PMC9408823__F8 FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer’s Disease 1020 983 867 5829 207 7157 2534 6714 5170 2932 3717 6772 6774 6194 1072 3643 28 3667 4139 PMC9409235__F2 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease 7038 3667 2308 1788 5728 200186 6713 2194 7030 22937 201163 PMC9409235__F3 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease 10628 8408 2308 7942 5467 130497 5728 1788 7097 54106 7099 114548 PMC9410784__F2 Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma 6722 1386 7124 PMC9413412__F1 Crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer 23657 2879 6520 10162 2182 5447 55240 1803 1432 PMC9415972__F1 Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology 7099 7124 3569 4615 3553 PMC9420645__F1 Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease 114609 7189 7099 4615 23118 257397 3661 3665 7187 PMC9420941__F5 Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases 6010 9344 51347 57551 9965 2264 154796 64423 60485 9113 26524 84962 100271694 PMC9421066__F2 Crosstalk between sonodynamic therapy and autophagy in cancer 2475 9776 8408 60673 8678 29982 9140 10533 9474 100170220 64422 PMC9424846__F4 Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection 149233 57291 100124700 283120 6774 3553 60674 84818 7189 378938 PMC9425297__F10 The role of FAM72A in SHM and CSR 729533 7374 4436 2956 PMC9428246__F4 Propofol on macrophage activation and function in diseases 383 4360 6774 7124 3569 3627 7808 7099 PMC9434120__F1 Relationship between metabolic reprogramming and drug resistance in breast cancer 27040 2194 7038 587 2597 5723 2147 4609 5209 875 2744 PMC9434367__F1 Inside the Noonan “universe”: Literature review on growth, GH/IGF axis and rhGH treatment: Facts and concerns 867 5781 2885 3845 8036 5500 673 5894 3265 22808 4763 1431 6016 8216 6654 6655 PMC9435021__F3 Biological and neurological activities of astaxanthin 842 836 572 581 4094 2730 2729 7124 8717 PMC9444135__F1 Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance 3383 7412 847 8205 2475 PMC9444450__F4 Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis 1730 2252 10266 1213 983 1660 2335 3479 7150 4691 10818 8452 3320 10128 1956 3091 988 9188 4193 55832 7153 5411 120892 1080 PMC9445052__F7 Inhibition of mTOR in bovine monocyte derived macrophages and dendritic cells provides a potential mechanism for postpartum immune dysfunction in dairy cows 2475 1437 3458 3569 3606 3592 3593 4843 3565 1435 3586 7124 941 384 9332 PMC9448575__F3 Crosstalk between Oxidative Stress and Exosomes 4088 1956 100616407 6648 847 PMC9449101__F1 Key Metabolic Regulator of Bone and Cartilage Health 84890 875 51380 790 PMC9449326__F2 Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis 1017 930 613 3479 5728 5595 5879 4790 27159 2263 3164 1950 2475 7097 2932 7422 3569 672 7249 3688 572 847 4609 3082 2335 5970 1956 468 5934 10682 1977 4602 PMC9450364__F4 Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells 5445 58478 7358 6418 9054 11214 81605 1854 1540 8697 7083 5567 1020 51079 4704 374291 4711 4709 1327 4722 4695 4725 7381 PMC9454399__F5 Qingfei Jiedu decoction inhibits PD-L1 expression in lung adenocarcinoma based on network pharmacology analysis, molecular docking and experimental verification 11201 940 23379 920 114609 3932 9615 5728 27040 10538 8190 PMC9460763__F5 Impaired autophagy with augmented apoptosis in a Th1/Th2-imbalanced placental micromilieu is associated with spontaneous preterm birth 581 64422 10533 9474 PMC9461657__F4 Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions 2475 2932 983 9776 8408 4661 10533 1021 595 65018 898 29110 995 5347 472 23192 5289 PMC9465172__F2 Exposure of metal toxicity in Alzheimer’s disease: An extensive review 540 538 9973 10063 2932 351 PMC9468713__F7 Anti-Osteoclast Effect of Exportin-1 Inhibitor Eltanexor on Osteoporosis Depends on Nuclear Accumulation of IKBA–NFKB p65 Complex 7189 4772 1513 7514 PMC9468722__F4 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review 4089 331 4086 4090 1618 1617 23118 257397 10454 54514 346673 PMC9469902__F1 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy 59272 55922 6352 1956 920 PMC9469902__F4 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy 6774 8651 9021 6654 2885 2549 PMC9472369__F4 Effect of Nrf2 deletion on the proteomic signature in a human colorectal cancer cell line 3162 2944 2947 2948 2941 2950 373156 9446 4258 4257 216 2729 2937 2876 2877 493869 10257 2686 79017 1468 7296 10587 PMC9476258__F2 The potential of plant extracts in cell therapy 324 1499 4090 4086 860 4089 2885 PMC9478308__F6 Research into the mechanism of intervention of SanQi in endometriosis based on network pharmacology and molecular docking technology 613 6850 930 2885 5879 5728 951 7249 572 6009 51083 672 4609 5934 150365 PMC9478857__F2 Bronchial smooth muscle cell in asthma: where does it fit? 952 847 5879 387 PMC9483202__F3 Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases 9817 7506 5728 2932 339834 847 23411 7351 PMC9492373__F9 Atractylenolide III Attenuates Apoptosis in H9c2 Cells by Inhibiting Endoplasmic Reticulum Stress through the GRP78/PERK/CHOP Signaling Pathway 25923 1998 468 22926 PMC9495339__F3 Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches 8454 9978 8452 9817 2932 57716 1728 847 23764 4097 7975 PMC9496891__F4 Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases 637 5266 1869 6648 595 717 5226 1647 PMC9498478__F5 Stress Response Mechanisms of Salmonella Enteritidis to Sodium Hypochlorite at the Proteomic Level 283459 383 5805 55137 PMC9500181__F1 Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes 9817 2182 10162 2879 6520 23657 1723 PMC9504399__F4 Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos 56917 79192 2885 3730 23767 1848 6899 2241 53820 PMC9505027__F1 MicroRNA: A Linking between Astrocyte Dysfunction, Mild Cognitive Impairment, and Neurodegenerative Diseases 5594 7124 4513 5054 4194 6667 4087 1874 983 208 4193 7097 5728 4790 1021 2932 5879 5163 5164 6772 3654 2475 3479 3665 7189 693152 23118 3596 PMC9505762__F1 Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease 27035 3553 114548 4129 596 1652 PMC9511043__F4 Function and mechanism of histone Beta-hydroxybutyrylation in health and disease 55902 3065 3066 627 PMC9511810__F2 Base excision repair accessory factors in senescence avoidance and resistance to treatments 9817 4763 5728 4513 50507 27035 2237 5423 23316 1523 6304 338340 PMC9513225__F1 Implication of non-coding RNA-mediated ROCK1 regulation in various diseases 3717 693184 6774 104472715 5728 57291 999 1000 100306951 554212 4313 29092 5306 5111 100048912 PMC9514850__F9 Differential metabolic pathway and reaction analysis 109245082 847 3064 203569 PMC9515385__F11 Scheme depicting the relevance of the PGD2 pathway in AD and its potential as an AD therapeutic target demonstrated by timapiprant (TIMA), a DP2 antagonist 6657 4512 2475 PMC9521401__F2 Dietary organosulfur compounds: Emerging players in the regulation of bone homeostasis by plant-derived molecules 2810 860 355 875 4086 9242 4772 100187907 1513 81501 126014 1728 2730 2729 5052 PMC9521521__F2 Deciphering the role of transforming growth factor-beta 1 as a diagnostic-prognostic-therapeutic candidate against hepatocellular carcinoma 7046 7939 387 2885 2475 PMC9523668__F2 Targeting non-coding RNA H19: A potential therapeutic approach in pulmonary diseases 7040 1636 4088 1277 283120 100033819 2146 387 6495 860 6774 7099 3146 2495 114548 4763 5728 2254 999 9475 PMC9524158__F1 New insights into the interplay between autophagy and oxidative and endoplasmic reticulum stress in neuronal cell death and survival 9097 581 4609 PMC9535022__F2 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials 1956 1019 5728 2260 4193 1017 PMC9535022__F3 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials 9817 8452 6510 6520 PMC9535022__F6 Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials 5728 8405 51343 2146 4283 3627 3558 3562 1019 PMC9535683__F3 Cytoskeletal dysregulation and neurodegenerative disease: Formation, monitoring, and inhibition of cofilin-actin rods 6446 387 998 5879 54434 7408 10048 PMC9541200__F2 NAD+ deficiency in human congenital malformations and miscarriage: A new model of pleiotropy 93100 64802 349565 23057 54981 27231 55191 10135 6999 3620 125061 8942 143 56965 142 10039 10038 419 420 8564 23475 4860 23498 23410 23408 22933 23411 51548 23409 51547 83707 952 683 130013 PMC9542654__F4 Exploration of hub genes involved in PCOS using biological informatics methods 613 930 6850 1356 3667 5879 5728 5163 951 7248 7249 6009 572 6256 4193 672 4609 5934 1977 PMC9549801__F1 Relationship Between Ferroptosis and Diseases 2182 10162 100 2879 23657 6520 55240 7018 PMC9550454__F7 Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach 6622 8772 351 759 572 717 9776 29982 5179 55872 PMC9553361__F2 Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy 2638 538 1737 PMC9554963__F1 Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways 3466 1956 4609 83939 PMC9555037__F7 Ruscogenin Protects Against Deoxynivalenol-Induced Hepatic Injury by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through the Nrf2 Signaling Pathway: An In vitro Study 1728 2729 9817 PMC9555118__F3 Periostin: biology and function in cancer 1950 1956 324 1499 649 PMC9556833__F4 Ubiquitin-like processing of TUG proteins as a mechanism to regulate glucose uptake and energy metabolism in fat and muscle 10603 1398 3667 9882 23216 3799 348 116519 4035 11101 PMC9559516__F5 RKIP in the Regulation of EMT in the Tumor Microenvironment 5818 4072 387 999 PMC9561277__F8 APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus 6741 545 84126 11073 54465 PMC9561999__F4 Good, the Bad and the New about Uric Acid in Cancer 355 3156 7249 PMC9562620__F9 Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NFKB signaling pathway 3553 7124 4513 PMC9563116__F2 Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis 999 847 1499 6010 9113 26524 91653 PMC9563579__F1 Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation 7124 3661 3002 PMC9564207__F3 Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery 2638 51755 596 3579 6667 7515 7385 4313 581 PMC9569207__F8 Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases 847 581 7099 PMC9575458__F2 Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview 3643 3667 8660 100302203 5728 PMC9576928__F2 Advancement in understanding the role of ferroptosis in rheumatoid arthritis 6520 23657 2937 2936 2879 2512 2495 246 7037 8031 9474 10533 6772 55240 6319 2181 4015 2182 10162 PMC9577372__F7 Transforming growth factorB in tumour development 4313 4318 5728 PMC9578877__F12 Ageing-Associated Transcriptomic Alterations in Peri-Implantitis Pathology: A Bioinformatic Study 241 4137 7157 55711 865 2624 50943 5970 3630 5447 2597 6720 3551 3845 355 3643 6391 54205 2475 351 3205 3003 7018 7295 4149 3492 3725 8074 2353 23118 6885 7424 374 1950 8717 26291 4791 5156 7422 5159 3481 2261 3082 2064 PMC9579211__F3 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways 5728 5163 6009 7249 2475 PMC9583386__F1 Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer 941 114548 942 9332 383 4803 PMC9583502__F2 Review on the role of cyclin dependent kinases in cancers 6774 7408 1017 3091 4313 3383 150365 83478 4513 56950 10013 PMC9585326__F1 Mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle 3667 3643 27068 7099 PMC9589007__F4 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues 51660 11330 5467 10873 5162 5160 8050 1737 4191 5164 4200 4199 1431 2271 54704 50 6391 6389 6566 682 9123 3419 3420 3421 3418 8803 8802 3029 1738 1743 4967 23530 79944 PMC9589499__F3 Isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review 3146 3553 468 355 345 PMC9597983__F2 Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential 1956 79713 3643 572 355 340719 581 637 664 1017 PMC9599575__F3 Glycation-Associated Diabetic Nephropathy and the Role of Long Noncoding RNAs 23411 1950 3553 3479 3630 100124700 55384 85028 PMC9599635__F1 Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies 1283 6908 7018 PMC9599635__F2 Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies 5978 1283 6908 627 25942 7018 PMC9599708__F3 Copper-Dependent Kinases and Their Role in Cancer Inception, Progression and Metastasis 5163 572 4193 8408 9706 60673 9776 PMC9601999__F4 Genes Related to Cognition after tDCS in an Intermittent Hypoxic Brain Injury Rat Model 4803 10818 6461 126669 1398 2549 998 5879 29984 581 10763 PMC9602136__F14 Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells 335 5360 4199 PMC9603894__F1 Oncolyic Virotherapy for Prostate Cancer: Lighting a Fire in Winter 3665 3661 7187 3466 PMC9604507__F1 Reversible Platelet Integrin AIIbB3 Activation and Thrombus Instability 7450 2638 7408 5908 6850 695 100170220 PMC9604510__F2 Cell Component and Function of Tumor Microenvironment in Thyroid Cancer 6714 999 5159 PMC9604797__F2 Carotenoids from Marine Microalgae as Antimelanoma Agents 1021 1019 5728 5925 4193 PMC9604797__F3 Carotenoids from Marine Microalgae as Antimelanoma Agents 5728 1021 1019 595 2932 999 1499 PMC9609612__F9 Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2 57506 3661 23252 6095 406 23411 3146 PMC9612159__F2 Nano-Based Drug Delivery Systems for Periodontal Tissue Regeneration 4772 126014 6002 10326 6001 100187907 PMC9612825__F1 Metabolic network 2539 2597 7084 4199 4118 8544 6120 4190 4191 2548 2805 2875 1431 11113 2806 PMC9616789__F10a Spatial Analysis of Neural Cell Proteomic Profiles Following Ischemic Stroke in Mice Using High-Plex Digital Spatial Profiling 43 3416 84890 4023 7939 8772 351 671 5447 572 790 6476 324 836 90550 545 7124 100506742 238 1311 22863 PMC9673319__F6 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease 627 114815 28 55737 5662 6868 PMC9846474__F6 Unraveling the links between neurodegeneration and Epstein-Barr virus-mediated cell cycle dysregulation 9212 1021 1019 4193 472 545 3663 PMC10030510__F2 Metabolic regulation of dendritic cell activation and immune function during inflammation 3939 3099 51660 2194 1374 PMC10033690__F1 Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons 4512 4513 5730 9536 5732 5733 5740 5739 5228 5737 6915 PMC10039534__F2 Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment 3458 3558 8205 50943 567 2932 3002 3627 4734 PMC10040566__F2 Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target 7424 84818 7189 23118 8205 4327 4312 PMC1087229__F8 Signaling pathway of NGF-induced neurite outgrowth in PC12 cells 4803 6654 10451 7410 5879 998 PMC1143566__F4 Schematic diagram for the Wnt signaling pathway 23002 6010 998 1499 324 PMC116060__F6 Proposed signal transduction pathways involved in PKC-mediated SRE activation 5879 387 6722 PMC1215521__F7 Possible gene regulation in macrophage THP-1 stimulated by theophylline 3572 7424 948 6948 23574 7016 6778 PMC137498__F6 Regulation of Cdc25A by Chk1 993 995 1017 PMC138838__F1 Signaling through mammalian and Drosophila Toll-family receptors (TLRs) 3929 7099 929 4615 PMC1420312__F5 Impact of SV40 ST on the Notch, Wnt, and Hedgehog Pathways 22943 7481 28514 182 81029 6469 7476 4853 1003 8324 4035 1499 6608 3728 324 83595 607 2736 7091 4088 3065 4316 4314 9076 4513 2335 960 51176 7490 3398 204 2201 284 8886 29968 6693 23246 1848 307 4938 2734 3383 2634 7102 PMC1431720__F7 Cytokine release in RAW 264.7 macrophages 3458 3566 51284 7099 7096 6772 PMC1436036__F12 Core signaling pathway downstream from V2R occupation in IMCD 2973 2597 551 2868 554 6261 409 2778 8417 4638 4628 5137 109 359 60 5138 112 5150 5575 PMC1481516__F2 Metabolic pathway and bioenergetics of net citrate production in prostate cells 1431 4118 11113 PMC1487177__F7 AKT-1/PKB Signaling 3643 5163 5728 207 208 PMC14940__F10 A signaling pathway of c-Met for cell scattering 3082 6420 2549 7410 6010 PMC1502529__F6 Network modeling 2064 1956 5335 2885 6464 8027 867 5781 2534 7410 5829 5747 558 3728 9146 5295 5296 2934 2060 10016 868 9815 PMC1526619__F2 The canonical transforming growth factor (TGF)B/Smad signaling pathway 4087 4088 4089 PMC1538848__F3 Expression data analysis and visualization on the PANTHER website 3416 2241 27040 PMC155638__F3 Hypoxic activation of apoptosis pathways 5728 572 317 PMC156240__F1 Xu-5-P is the signal for the coordinated control of lipogenesis 95 2597 11113 PMC1564158__F2 Predicting Essential Components of Signal Transduction Networks: A Dynamic Model of Guard Cell Abscisic Acid Signaling 5183 5954 2638 5091 5879 10006 PMC1681468__F5 Ellipsis in drawing association states of proteins using an 'address' 1950 1956 2549 2885 126669 PMC1681473__F1b (B) The bow-tie architecture also exists at the signal transduction level 4049 7097 7098 7099 51284 325 114609 4615 3661 3569 7124 920 923 6772 6775 6778 2625 7054 PMC175791__F10 Differential regulation of NFAT and SRF by the B cell receptor via a PLCG–Ca2+-dependent pathway 613 4067 6850 695 998 6007 6722 PMC1769521__F2 Senescence via tumor suppressor pathways 4193 1021 1019 1017 5371 23492 648 6909 PMC1779567__F6 Functional dissection of signaling modules in human TReg cells 7185 8772 3958 6275 7157 2272 94241 4193 9232 50943 324 3956 5292 4609 6778 6775 2625 6304 6932 3398 3575 8784 8795 PMC1781924__F1 Thy-1-associated signaling pathways 7070 387 4086 6774 5266 2534 27040 PMC1785339__F4 Human and mouse mutations and the cognitive disorders affecting specific NRC/MASC signaling pathways and other postsynaptic proteins 5354 2066 2892 8573 5063 PMC1839891__F1 Systems biology by the rules: hybrid intelligent systems for pathway modeling and discovery 2735 6608 2736 PMC1913098__F1 Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control 3976 3977 9021 6774 10401 PMC1940036__F6 Wnt/Axin1/Beta-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries 5308 8312 4838 PMC1991338__F1 ZIP1 expression and zinc accumulation in the pathway and bioenergetics of citrate production and citrate oxidation in normal versus malignant prostate cells 1431 4118 11113 PMC2063536__F7 ES cell–based model describing the ontogeny of NSCs 317 3976 2247 PMC2064670__F5 Model integrating calcium mobilization into the Fas signaling pathway 355 8772 637 PMC2099483__F1 Circadian oscillation in leptin signaling pathway in mouse brown fat 9021 3952 6774 3953 PMC2148057__F5 GenMAPP view of energy production pathway in MCF-7 and ZR75-1 cells 54205 291 121599 4709 1346 4715 4708 10063 1353 4707 4716 4711 1355 4731 4726 7350 293 6389 6390 7351 4514 6391 7352 4728 4696 4718 6834 4706 4724 4729 100187761 PMC2174913__F2 Checkpoints activated upon rereplication 5884 545 672 472 2177 995 1017 983 84126 PMC2174972__F7 The Viral Oncoprotein LMP1 Exploits TRADD for Signaling by Masking Its Apoptotic Activity 7189 4050 8717 PMC2180215__F1 Comparison of the protein kinase/phosphatase signaling pathways in flies, worms, and humans (see text for description) 998 2885 4478 6714 5728 4615 6850 7535 3932 PMC2195768__F6 Proposed signaling pathway of the purinergic receptor: regulation of cardiac autonomic activity 7006 100124696 2534 PMC2213034__F8 Our model for the mechanism of anti-CD63 inhibition 967 2534 4067 6850 9846 5163 PMC2213056__F1 AID-initiated SHM pathways 4436 2956 353497 7374 PMC2238789__F3 Hypothetical ‘super pathway’ not stratified for cell type illustrating known direct interactions between the 892 PD priority genes (regulation, expression and promoter binding only) 5649 43 8745 7018 5122 1738 84258 2775 6844 1759 2669 998 774 6616 6531 23229 273 7534 2932 4747 3303 6622 4744 7054 6252 6623 8766 3304 6620 8774 PMC22672__F8 Orb6 kinase is proposed to be part of a regulatory cascade contributing to the mitotic control and responding to the Ras1 and Cdc42-dependent morphological control pathway via the Pak1/Shk1 kinase 998 5058 7465 PMC2268661__F2 The diagram of GSH redox cycle 2879 2729 2730 2937 3418 PMC2270353__F4 NPTX2 pathway obtained by means of the Resnet 5.0 eukaryotic database of molecular interactions (Ariadne) overlayed with microarray expression values 2891 2890 2893 2892 4884 23467 4885 PMC2311292__F2 Pathway representation of all the tryptophan related genes analyzed 3630 131965 9836 51451 224 1545 836 2639 3033 51166 223 130013 4129 4967 8942 4128 2671 10498 3275 PMC2376243__F8 Schematic mechanism of AB oligomer-mediated aberrant PAK activation and translocation in Alzheimer disease pathogenesis 7074 2534 1020 PMC2386254__F11 A Bacterial Cytotoxin Identifies the RhoA Exchange Factor Net1 as a Key Effector in the Response to DNA Damage 10276 387 718 PMC2386284__F5 The mechanism of retinoic acid stimulation of NIS expression by modifying signal transduction pathways in breast cancer and thyroid cells, based on the results of the inhibitor studies 3479 3667 5879 7849 PMC2394768__F4 Network diagram comprising genes and functional processes associated with regulated AS events in the CNS 6010 23345 4976 2689 11252 4646 7867 PMC2408433__F1 Glucose transport regulation by the Akt/TSC pathway 7248 2475 7249 6009 PMC2417187__F7 Activation of the UPR in the absence of H6PD 811 7494 22926 468 PMC2430908__F8 Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity 3516 85480 10113 PMC2491599__F2 Wnt canonical signaling pathway 9350 11197 324 4609 3725 4316 PMC2494808__F3 Graphical representation of connections between receptors and pathways implicated in NTS baroreflex modulation by pharmacological studies 133 2885 998 4193 7249 2444 572 6722 PMC2496917__F1 Interfering the PI3K/mTOR/p70S6K signaling pathway 5266 5728 5163 2475 PMC2515306__F1 Wnt signaling pathway and its inhibition by AB aggregates 4040 4041 324 2932 7008 PMC2528242__F1 Peroxisome proliferator-activated receptorG and ligands: pathways and functions 7124 948 6774 6667 3725 2353 PMC2529314__F8 Over-representation of Toll-like receptor signaling pathway genes 7097 100187907 23632 23118 114034 PMC2574672__F2 Iron–sulfur (Fe-S) cluster biogenesis in eukaryotes 23479 2395 2242 2232 10101 22 26502 4682 9391 3313 51218 150274 PMC2575183__F7 Proposed signaling mechanism that stimulates EMT 3611 2932 999 1499 7043 51176 PMC2577427__F9 Model depicting signaling pathways for TPR-mediated modulation of OLG development and function 7175 6010 4512 PMC2585593__F1 Diagrammatic representation of pathways associated with aroma production and links to associated metabolic activities 466 1386 100 65057 PMC2586109__F1 Protein kinase C isozymes as therapeutic targets for treatment of human cancers 2932 5879 324 1499 PMC2593012__F3 Gene expression data mapped on the mouse insulin signaling pathway 5880 4137 4099 5602 2191 5603 3725 4118 57381 PMC2593440__F3 Network of differentially expressed genes in the cell cycle control pathway in sorted R1/R2 Eklf−/− E13.5 fetal liver cells 1280 10766 29883 5504 3490 351 902 1019 10645 1021 2968 5501 2965 5934 3398 5198 1719 5933 2870 2117 4692 1870 9184 4085 10038 2553 144455 142 23429 427 PMC2597730__F7 Cascade between VEGFA, a direct target of BP1, and its downstream target genes in cell proliferation 671 4151 2065 8864 6597 1081 5327 1392 3397 2925 673 8660 6403 4842 8165 5170 PMC2606015__F9 Schematic view of the Vav family-regulated signaling pathways of DT40 B-cells 613 6714 6850 10451 29760 5879 387 695 5337 25780 2885 PMC2615236__F1 Regulation of IGF-I Function by Proinflammatory Cytokines: At the Interface of Immunology and Endocrinology 3480 2885 5266 5163 1977 10000 207 208 1499 572 7249 2475 PMC2631600__F1 The HMGCR pathway 3156 6309 1717 PMC2634812__F3 Stepwise respecification of ETP and DN2 cells by GATA-3 overexpression 2625 7070 2624 4286 1359 PMC2634812__F4 Myeloid diversion pathways for advanced pro-T cells by re-introduction of C/EBPA or PU.1 3398 4602 4851 2625 3932 171558 4353 596 1959 53335 64919 2114 2113 PMC2645538__F5 Possible neuroprotective mechanisms of mild mitochondrial uncoupling and caloric restriction in neurodegenerative diseases 23411 142 627 PMC2649265__F8 Insulin-PI3K-Akt signaling in AD 3630 3479 5163 3667 2475 253260 5164 1690 2932 PMC2649808__F5 Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions 95 867 2885 1398 355 2475 57120 PMC2650010__F1 Akt-dependent and independent mechanisms of mTOR regulation in cancer 5728 5266 5163 7248 7249 6009 253260 2475 64223 PMC2651582__F1 Metabolic reprogramming in tumor cells 3099 3098 2194 5163 1374 PMC2652039__F8 Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta activated kinase 1 7187 7185 7188 7186 6347 7412 PMC2662565__F3 Bipolar disorder: from genes to behavior pathways 4082 627 1499 PMC2670969__F4 PBT-1 induced genes in different pathways according to the KEGG and BIOCARTA pathway databases 993 983 1022 902 1019 1017 1021 5163 2690 572 2475 PMC2671988__F2 Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder 8774 2918 4763 5728 5163 2475 7248 7249 PMC2673912__F6 Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation 983 5347 1647 6950 10111 2189 5970 999 1039 472 672 324 699 991 1017 4193 7422 4998 993 51512 PMC2673912__F8 Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation 2005 10682 1050 7421 1958 1499 1385 6667 4149 PMC2683622__F9 Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway 51135 5310 3654 7189 4615 7187 PMC2696328__F5 Proposed model for the effect of HPTE in the granulosa cell 2492 3480 26585 1499 7536 1588 PMC2696359__F1 TNF-Induced MAP Kinase Activation Oscillates in Time 7124 8717 7186 7185 10892 11140 PMC2696566__F1 Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy 3480 3667 6010 998 3265 6714 5728 5163 2475 208 4208 PMC2697617__F1 Live Longer Sans the AT1A Receptor 1950 1956 3667 2885 387 207 2475 6868 PMC2699768__F1 Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism 1956 2932 1499 PMC2699904__F8 Schematic showing inter-relationships of clustered genes associated with fatty acid, lipid and lipoprotein homeostasis based on differentially-expressed genes identified in lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice 38 39 10654 6774 5824 2222 6713 4047 19 PMC2710138__F2 Phosphatidylinositol 3—kinase (PI3K) signaling pathway 5728 5163 5879 998 7249 7248 6009 4193 572 PMC2710138__F8 Feedback inhibition of the phosphatidylinositol 3—kinase (PI3K) pathway 5728 5163 2475 64223 253260 7249 6009 PMC2714185__F3 Major regulatory steps in the process of DNA damage response (DDR) 10111 5888 4361 5893 675 672 84126 472 545 9656 5371 PMC2716751__F2 The concept of angiotensin II-growth factor cross-talk in ureteric bud morphogenesis 9353 6092 2303 2296 717 652 367 2297 7484 5076 2255 2252 183 2668 10252 1956 7481 PMC2718491__F3 Multiple regulatory pathways for N-WASP and WAVE2 activation 998 10011 10152 51225 10006 56961 PMC2720375__F7 Genome-Wide Screen of Genes Required for Caffeine Tolerance in Fission Yeast 5888 1200 7018 466 1233 3040 PMC2721475__F1 Downstream targets of IGF-1R 7249 7248 3667 2885 2475 PMC2722780__F8 Putative BK-BKAP interactions derived from the BK interactome in mouse cochlea 55327 100187761 2597 572 6418 PMC2723867__F1 Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses 324 3383 613 930 4067 998 2534 3932 7535 5880 5879 29760 5336 5091 PMC2724105__F2 The postreceptor insulin signaling pathway and insulin-independent 5′-adenosine monophosphate kinase (AMPK) beginning from insulin binding to its receptor to GLUT4 translocation via vesicular trafficking 3630 5728 5163 5164 207 208 PMC2725405__F6 Regulation of IFN response genes by TLR3 signaling 3661 7098 1386 PMC2731164__F7 Embryonic Stem Cell Differentiation 701 994 990 993 991 8317 1017 1387 1022 1111 11200 1874 9700 3065 51343 10926 1869 4171 4173 4172 4174 4175 4193 9088 2810 5591 5347 8243 27127 1677 1676 1147 637 11213 472 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novo Purine Nucleotide Synthesis 4693 7808 5814 PMC2747034__F1 MTDH/AEG-1 promotes tumor progression through the integration of multiple signaling pathways 218 92140 3162 1806 1646 2932 85320 664 1499 51176 4609 PMC2749259__F2 Hypothetical diagram of possible sites of action of non-opioids in the regulatory pathway of IL-6 3716 6774 6772 9021 PMC2749675__F1 Scheme of the Wnt signaling pathway 4041 4040 2932 23002 93956 324 1499 51701 999 PMC2749695__F4 Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target 657 5728 324 1499 6009 4193 2475 595 4609 PMC2749725__F1 Coverage of the insulin receptor signaling pathway 5728 2885 6247 5163 1398 572 2475 1384 2887 1977 79629 PMC2756021__F3 Neuroprotective Effects of the Complement Terminal Pathway During Demyelination: Implications for Oligodendrocyte Survival 355 572 637 581 PMC2756670__F3 Potential mechanisms of estrogen-mediated signaling through estrogen receptor (ESR) and G protein-coupled receptor 30 (GPR30) 1839 1956 6714 PMC2756767__F2 Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer 3099 3098 355 PMC2756767__F3 Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer 3480 3099 3098 2475 5163 5091 PMC2757632__F1 O-GlcNAc cycling: Implications for Neurodegenerative disorders 8473 10724 23636 22906 PMC2759974__F1 MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer 7471 2932 324 1499 2353 3725 595 1758 1019 4193 993 1719 PMC2760069__F1 Brothers and Sisters: Molecular insights into arterial-venous heterogeneity 8829 2296 2303 2324 1601 8828 4851 2050 23493 23462 54345 83595 PMC2762009__F1 The Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders 100170220 4666 3265 5662 PMC2762604__F11 Proteomic and Phospho-Proteomic Profile of Human Platelets in Basal, Resting State: Insights into Integrin Signaling 686 6714 5478 5170 PMC2764428__F4 MiRNA/TF-mediated regulatory pathway associated with tumorigenesis 1869 604 6774 406952 7020 7157 1960 3224 4609 2113 60468 5077 1871 11278 4602 6908 PMC2769253__F1 MicroRNAs in cancer 693156 100187761 29102 PMC2771724__F4 Synaptic Long-Term Potentiation: Genes differentially expressed in the NAC of LE vs 2890 51422 5530 5507 816 5594 PMC2772137__F4 Temporal Profiling of Rat Transcriptomes in Retinol-Replenished Vitamin A-Deficient Testis 38 39 3157 1586 2224 2222 3283 PMC2773299__F2 Schematic representations of the activated RAS-MAPK, RASSF1A/NORE1A, and Dab2IP/ASK1 pathways, iNOS signalling, and FOXM1-related pathways involved in the dysregulation of cell growth and apoptosis in HCC 153090 11140 1601 5894 4485 2735 331 2305 1843 6790 7422 6502 994 4751 2056 PMC2782644__F5 Differentiating Human Multipotent Mesenchymal Stromal Cells Regulate microRNAs 2353 196 5156 6774 867 4609 3054 5159 7040 4790 PMC2782690__F3 Is cancer a disease of abnormal cellular metabolism? 4609 57103 2147 11113 4553 PMC2783472__F1 Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy 472 672 10111 4361 1869 3014 4193 581 PMC2783472__F2 Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy 472 545 995 993 5371 672 983 1017 581 PMC2783837__F2 TRAIL-R1/-R2 apoptotic signaling pathway 8772 637 331 PMC2784662__F1 mTOR Signaling Cascade 253260 5163 2475 5728 6009 1977 1999 PMC2786873__F9 Model of amino acid starvation-induced AARE-dependent transcription in human cells 5879 998 83939 468 1386 467 PMC2787730__F11 TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the apoptosis pathway 7939 355 8772 8717 7186 2021 4615 637 4803 572 472 581 PMC2796182__F4 Regulation of nitric oxide signaling by thrombospondin-1: implications for anti-angiogenic therapies 4018 948 961 2247 2534 6714 PMC2803786__F2 Network analysis of the top 250 predictor genes 10973 8976 267 6612 9341 1846 2633 1054 27336 64601 10379 196 858 3308 9254 388 6890 1471 7852 3854 6288 6749 3134 23524 26292 PMC2806519__F8 Prostaglandin F2Alpha-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium–calcineurin–NFAT pathway 3576 5228 3579 11123 10231 1827 PMC2808176__F1 Example of pathway segments corresponding to FALZ identified from breast cancer data (Figure drawn with Cytoscape) 2203 114932 2065 26136 51466 7257 3572 7507 902 4036 5327 596 2099 4651 2752 4582 6880 9604 8204 7494 3728 3551 4602 4904 3667 PMC2808370__F7 Possible mechanism by which Wnt determines the specificity of signalling pathway 22943 89780 4040 324 6010 1499 PMC2812679__F8 TK-mediated signaling pathway promoting HaCaT keratinocyte migration 367 1839 1950 6714 PMC2820748__F6 Sites within the early steps of the insulin signaling pathway affected by OGT and O-GlcNAcylation 6774 8473 6667 5163 PMC2825767__F1 Adrenal insulin signaling and glucose transport gene expression is overexpressed in the chromogranin A (Chga) knockout mouse 6517 3643 5290 2885 5291 5296 2887 2888 10211 2319 10487 8660 25759 6236 5294 5286 30849 867 53358 6812 6813 6814 252983 50964 5879 8471 6655 5880 5288 2549 5289 1398 23433 6844 5606 6416 5607 5608 11184 5871 8491 9448 1432 4214 5594 7248 8773 6616 5170 6009 11127 10746 4215 5595 7249 10110 5596 5597 5598 4216 375 4217 9064 6885 1326 4293 4294 4296 7786 9175 9020 2932 9882 6198 6199 57381 5867 10603 2308 2353 10938 2002 3725 30846 6722 50488 5781 5792 5770 5167 3551 5584 7494 5588 5578 5590 2997 57761 5728 5501 2992 3636 9021 5580 2998 5563 5583 3991 PMC2825767__F2 Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse 1717 3156 1113 6309 4598 50814 10654 4597 3422 4047 2224 6713 2222 PMC2825767__F3 Hepatic cholesterol biosynthesis pathway gene expression is globally overexpressed in the Chga knockout mouse 1717 3156 1113 6309 4598 50814 10654 4597 4047 2224 6713 2222 PMC2826554__F1 Beta-AR-dependent translation initiation 5163 2475 1977 PMC2826600__F4 Insulin and IGF1 signaling pathway to promote glucose uptake by GluT3 in neurons (shown) or GlutT4 in muscle (not shown) 3479 5360 2475 9817 PMC2827616__F8 Signaling pathways controlling ENS precursor migration and lamellipodia formation 2674 2668 126669 5979 2885 998 5728 5879 6010 PMC2828612__F1 Putative mechanism by which the UPS acts downstream of BDNF/TrkB signaling to ultimately regulate Alpha-synuclein aggregation 355 8772 627 PMC2829367__F1 Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy 960 999 1499 2932 7291 51176 595 PMC2831538__F3 Autophagy regulation in response to stress 83939 9140 2475 7248 7249 664 PMC2834246__F2 Regulation of chromatin structure by drugs of abuse 10014 4852 627 1020 2354 PMC2834303__F9 PI3K-Akt pathway negatively regulates LPS signaling and gene expression in mouse macrophages by inhibiting the activation of MAPKs 5163 5728 1958 1386 7124 7018 PMC2834863__F1 Transforming growth factor beta (TGFB) and inflammation in cancer 5340 11171 4092 57154 6010 998 6497 7189 4214 1616 PMC2836783__F2 CD62L regulation by T-cell receptor (TCR) stimulation and Gc-cytokines 3601 3558 3600 3575 3932 2534 7535 6868 2308 2475 10365 1236 PMC2840262__F2 Autophagy and the Ubiquitin-Proteasome System in Cardiac Dysfunction 4077 9531 573 10013 PMC2844177__F9 P38 MAPK signal transduction in melanogenesis 4157 7391 4286 1638 PMC2844640__F3 Role of Radiation-induced TGF-beta Signaling in Cancer Therapy 581 4089 4092 PMC2847412__F1 Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis 22926 2160 1388 83939 7494 468 PMC2850399__F7 Mevalonate pathway and the pleiotropic effects of statins 6010 335 998 PMC2852112__F1 Scheme of the autophagy pathway 2475 22863 9140 9474 83734 10533 64422 PMC2853371__F9 CD28 costimulation, IL-2 signaling, and mTOR pathway regulate Otub1 and GRAIL expression, controlling proliferation in primary naive CD4 T cells 940 324 2475 55611 920 5091 PMC2853417__F6 Differentially expressed genes in the ERK/MAPK signaling pathway 2885 1398 5293 11069 4342 6722 6772 PMC2853417__F7 Differentially expressed genes in the estrogen receptor signaling pathway 27043 6908 8431 10498 8841 1655 3484 PMC2854193__F1 Autophagy Genes as Tumor Suppressors 5728 60673 2475 7249 7248 7405 55626 9140 83734 10533 84938 64422 100170220 PMC2854249__F2 Mammalian autophagy: core molecular machinery and signaling regulation 8660 3667 5163 2885 5728 7248 7249 6009 572 PMC2855202__F3 Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion 6667 5728 5163 8473 10724 2932 6844 PMC2855687__F1 The kynurenine pathway with relevant regulatory components, summarizing gene expression and metabolite changes previously identified for schizophrenia in the frontal and anterior cingulate cortex 4161 6999 8564 8942 2847 23498 130013 23475 PMC2856448__F1 Opposing influences on Foxo cellular localization and transcriptional activity 4485 5728 3276 8473 5163 23411 PMC2856775__F1a Convergence of Pathways in TLR and IL-1R SignalingUpon activation, the IL-1 receptor dimerized with the IL-1 receptor accessory protein 7096 7097 7099 10333 114609 51284 54472 54106 4615 3661 3654 7189 PMC2859933__F9 Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain: Novel Analysis of Retrospective Cases 406906 574504 693174 407004 406910 1438 1674 2029 93986 759 PMC2860348__F1 p38 MAPK mediates the transcriptional response to stress 1386 1649 6657 1959 3400 3397 2627 3725 860 4772 3170 4092 6662 2296 2353 2297 5075 4609 1958 2290 7050 467 3659 3398 3228 23764 64211 64332 PMC2860693__F8 Simplified model of the signaling pathways regulating radiation-induced bystander effects 7124 90865 3569 472 3486 3479 6761 3480 847 51176 3717 6774 4513 PMC2864141__F1 Models of checkpoint control in (a) S 5810 3364 5884 286204 1040 7465 5426 5985 PMC2864453__F1 Nuclear factorKB (NFKB) can be activated by a multitude of different stimuli, like TNFA, LPS and CD40L 958 7099 929 5971 PMC2864762__F13 CFTR Depletion Results in Changes in Fatty Acid Composition and Promotes Lipogenesis in Intestinal Caco 2/15 Cells 338 7038 6256 PMC2869029__F1 Regulation of macrophage function in tumors: the multifaceted role of NFKB 3454 3455 4615 6774 3659 3661 3665 6778 3663 383 384 3569 3553 3627 9021 PMC2875624__F1 Alterations in transforming growth factor beta signaling cause changes in chondrocyte differentiation and osteoarthritis development 57154 64750 4091 4092 4087 4088 4090 4086 860 PMC2878924__F6 Two models for coupling the circadian clock to the cell cycle/checkpoint response 9575 406 7507 7465 84126 545 472 PMC2879143__F3 Activation of apoptotic signaling via caspase 3 and gelsolin 331 4137 324 6093 22985 2339 PMC2880683__F1 Insulin signaling pathway 5163 253260 2475 5728 5164 3667 PMC2881822__F8 ERB Impedes Prostate Cancer EMT by Destabilizing HIF-1A and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading 8829 7422 999 PMC2882520__F3 Disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5) 3630 182 716 2671 6521 5091 6559 7429 2584 5409 4638 80306 329 708 2242 1385 11073 891 4171 1633 27043 9055 2100 PMC2885511__F2 Diagram of PDGF-D cross-talks with other pathways 5340 80310 999 2475 PMC2885703__F11 WNT1-Inducible Signaling Pathway Protein-1 Activates Diverse Cell Survival Pathways and Blocks Doxorubicin-induced Cardiomyocyte Death 5728 581 2932 1499 PMC2886325__F3 PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL) 1950 3479 5728 7249 7248 2475 PMC2889938__F2 Target gene regulatory network, NFKB/RelA:P50 2919 3559 7076 4283 2633 6356 6890 7412 5783 5971 3726 330 3601 7124 7528 4609 5970 4790 6374 3586 3600 4050 3514 6775 969 9021 6363 2920 355 4792 2335 598 596 3659 3665 2152 6403 3553 4891 4318 6348 3109 3383 1437 5747 3569 7040 51561 4092 PMC2891859__F1 General overview of BDNF and GDNF signaling mechanisms 627 2668 2674 5979 2534 6010 596 PMC2891946__F7 Crosstalks between EPCR, PAR-1, S1P1, and Tie2 7054 5091 857 387 5879 PMC2891968__F5 Cellular pathways leading to upregulation of COX-2 in neutrophils 3929 929 7099 PMC2892366__F10 A model for the function of GCN2, ATF4, ASNS and Asn in conferring tumour cell protection from microenvironment stress 83939 468 440 6509 PMC2892459__F5 Overlay of IfnB timecourse analysis onto the macrophage pathway using BioLayout Express3D 51284 7098 4615 92610 958 637 835 7124 840 7132 5610 8743 596 355 1616 8837 5698 2633 6890 3660 3600 3627 3433 1536 4283 3659 6773 6772 3459 3717 9021 3665 8651 3663 PMC2895421__F2 Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway 3551 8835 8651 7124 5290 3569 3565 5728 7249 7248 207 2475 PMC2896868__F2 Toll-like receptors in kidney disease 3929 929 7099 51284 54106 51311 7100 7098 7096 10333 7097 114609 59307 7187 4615 3665 51135 29110 7128 7189 10454 3661 23118 5970 467 PMC2897923__F2 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression 115908 5879 718 387 9475 PMC2898136__F3 Eicosanoids and cancer 1956 6714 2932 1236 4313 PMC2902148__F1 VEGF signaling interactions 7424 7423 5281 7422 8828 8829 PMC2903791__F11 Cell signaling model for the regulation of glucose metabolism in hepatocytes by taurocholate 1956 6714 5163 3667 PMC2905316__F2 Involvement of the Notch signaling pathway during endocrine cell differentiation 23531 3280 4760 PMC2907396__F3 Genome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue 2534 867 27040 2885 2922 3725 2002 4775 4773 5970 PMC2909654__F5 Examples of human disease phenotype correlations in the absence of metabolite sharing but detected by flux correlations 1373 2235 5498 5009 210 7389 7390 435 PMC2910166__F7 drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans 10890 7458 1977 PMC2912833__F3 Generation of a biological network of genes of the most significant Canonical Pathways for the EF·CIF (Il10-/- vs 2170 3158 37 2167 5465 4556 4242 3111 3659 3108 1559 217 5603 3109 PMC2915874__F3 ER-activated postreceptor mechanisms 6714 1839 1956 PMC2915874__F4 Effect of estrogen on endothelium-dependent pathways of vascular relaxation 2638 6714 4512 PMC2916958__F7 Proposed model for the role of NOX4 and DUOX2 in promoting cell cycle entry 50506 50507 595 1019 PMC2920345__F3 Viral tricks to grid-lock the type I interferon system 7297 3716 3630 6772 4553 6773 54738 10379 PMC2921989__F1 Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein 581 2475 5728 3486 3479 7249 4193 27165 57103 92421 3976 PMC2924379__F2 Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis 637 572 8739 581 666 638 836 27429 2021 56616 4671 331 7189 8717 8772 841 PMC2924908__F2 Complement - a key system for immune surveillance and homeostasis 1401 8139 324 7448 PMC2924916__F2 P-values for testing association of the genes within the MAPK signaling pathway with RA in WTCCC studies 5567 5578 4803 627 4908 4351 1950 2885 6722 4342 2316 1398 3727 7124 7186 1616 4149 929 23118 51295 994 9344 51701 PMC2924916__F3 P-values for testing association of the genes within the MAPK signaling pathway with RA in NARAC studies 4803 627 673 1950 3845 6722 6237 4342 4609 2317 3725 5801 7186 1616 355 4149 7189 51295 51701 PMC2927928__F3 Molecular pathways involved in pancreas and liver differentiation from hES cells 3651 4825 3170 174 6662 213 256297 2247 2255 PMC2928685__F1 Schematic diagram of the interaction of HH signalling on p53 and Nanog 79923 6295 6608 5728 4193 6657 5091 3535 PMC2929951__F8 Mapping Drug Physico-Chemical Features to Pathway Activity Reveals Molecular Networks Linked to Toxicity Outcome 2932 1499 324 2335 23002 9475 387 4747 4741 4744 2876 867 6714 7039 3725 2885 4609 PMC2930641__F2 MAPK Signaling Pathway 4803 627 1950 1956 4351 2002 5228 2885 5894 6722 4342 4763 2316 3727 5062 5058 7186 355 1616 4149 10454 4208 929 23118 7189 51295 994 51701 PMC2933269__F1 Activin signaling regulates transcription of the FSHB gene 4088 4089 4092 2488 PMC2934775__F8 Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where carbon-limiting medium is changed to nitrogen-limiting medium at time zero 5805 7084 11113 4118 PMC2934775__F9 Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where nitrogen-limiting medium is changed to carbon-limiting medium at time zero 5805 7084 11113 4118 PMC2938637__F2 Current model of early symbiotic signaling pathways 79902 55746 51199 PMC2945394__F1 Post-pandrial increase in insulin leads to induction of lipogenesis and inhibition of lipolysis 4023 95 7038 PMC2945552__F11 Proposed signaling pathway modulated by TH2-3 in LPS-induced RAW264.7 cells 4615 4513 5144 929 PMC2946555__F2 Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival 999 4485 9113 PMC2947266__F10 The signaling transduction pathway leading to tPA induced fibroblast proliferation 4035 2932 595 PMC2948329__F2 TSC1/2 integrates multiple signals to control cell growth and proliferation 7248 5163 1017 6009 PMC2949481__F2 Insulin, IGF-I and IGF-II signaling through the IGF-IR 3667 2885 5163 5728 572 7248 7249 4193 6009 2475 PMC2955136__F3 Highly expressed proteins in MII oocytes 4099 4149 5970 6304 8819 1108 4841 7054 5425 PMC2955136__F4 Highly expressed proteins in zygotes 51127 7320 7322 7324 3458 6184 6185 213 348 22905 1622 721 1431 4191 3421 4190 178 567 54472 18 PMC2955921__F2 Scheme summarizing the differential effect of PARP-1 inhibition versus silencing on SSB repair via the BER pathway 6741 6697 5111 PMC2966480__F4 E3 ubiquitin ligase activities of KEAP1 and AHR 196 405 9817 8452 367 9978 PMC2967585__F9 Mechanisms involved in alcohol-mediated suppression of type I IFN pathway in human hepatocytes 7297 3716 6772 6773 3663 3661 8835 9021 PMC2974170__F1 Diagram of TLR signaling pathways 4615 114609 51135 7189 3654 29110 10454 3661 3665 7098 54106 51284 51311 PMC2974212__F3 Critical growth factors and signalling pathways controlling human trophoblast invasion 3082 1950 6010 2475 PMC2976970__F3 Protein-protein interaction map of Notch transcription modifiers 25942 55929 1024 9440 6203 6128 4602 1025 6218 6143 23049 26019 7272 9843 PMC2987484__F1 Pathway analysis on differentially expressed genes 1131 1813 887 3356 4099 5228 5122 81848 6863 9353 6696 6750 1942 23580 25825 351 2327 2534 10200 4117 3984 4744 4212 8073 6144 6273 84867 23358 6597 7345 4070 7064 282974 2882 373156 2880 2827 4255 4311 5153 5099 7124 376267 PMC2997737__F1 AKT/MTOR pathway 3667 5728 5163 5164 4193 7249 7248 6009 79109 253260 2475 64223 PMC2998559__F1 Model Depicting major molecules and events in mast cell activation 27040 84876 9846 695 6786 4067 2885 6850 10892 PMC3000367__F5 Scalable Approach for Discovering Conserved Active Subnetworks across Species 79923 2786 5080 2249 6657 899 4001 10769 891 4605 7474 2735 5915 7545 2295 7547 2692 22918 7275 961 3932 5788 719 2207 140885 PMC3000843__F1 Schematic representation of chiral 3HV production via the threonine biosynthesis pathway in metabolically engineered E 7067 157739 3045 100187828 PMC3001303__F1 mTOR signalling pathway 3667 5728 2475 64223 7249 253260 6009 PMC3003974__F3 Protein interaction network of highly connected proteins associated with the cardiorenal syndrome 1535 27035 4689 4688 5468 5970 2353 1432 5581 5291 1956 1910 1051 183 5294 6714 1909 5293 59272 1950 545 3630 3572 2048 PMC3004331__F3 Differential host transcriptional responses within the acute-phase response pathway in r1918-infected WT, TNFRKO, and IL1RKO mice at 1, 3, and 5 dpi 8717 4615 7189 51295 3929 197 350 183 718 2335 6648 3273 7018 6774 5163 2475 2002 2243 2266 12 3263 3240 57817 1356 2147 2244 727 7450 5265 717 PMC3005418__F8 Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery 9055 11201 3066 6657 PMC3010252__F1 Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms 3265 1431 3845 6654 2885 4763 5894 673 161742 8036 PMC3011046__F2 FAS generates an endogenous ligand for PPARA in liver 355 907 10390 5465 PMC3012138__F3 A network of hits highly enriched in cell cycle-related genes 1607 545 324 85366 29904 7223 2798 5570 6160 5901 5631 2444 3172 55670 337 5754 5730 PMC3013804__F3 Case study of the discovered phosphorylation networks associated with insulin signaling pathway 5879 2064 3643 3716 998 5058 6464 2645 2885 2549 6654 7535 207 5894 572 1432 5599 3667 5598 4609 7157 2002 3725 1950 PMC3016978__F6 Model for a meiotic gene regulatory cascade initiated by inactivation of a pathway that promotes turnover of meiotic transcripts produced in vegetatively growing cells 9985 101928601 2203 7216 PMC3021128__F7 Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7 4173 4176 4172 4171 4174 4175 PMC3022727__F6 IPA pathway graphical representation of Aryl Hydrocarbon Receptor Signaling 7042 8988 9446 4257 2941 4329 220 219 5832 2953 4258 2940 2947 216 2949 2944 373156 4790 898 5422 196 2100 1029 1027 890 1021 135112 5915 1111 5469 5916 1026 5925 4774 1719 PMC3023199__F4 Dysregulated expression of fatty acid and cholesterol synthesis genes in liver is reversed by PPARG ligand treatments 6720 31 355 4598 10654 5447 6713 4047 95 57678 PMC3023986__F2 Wnt Signaling as a Therapeutic Target for Bone Diseases 4041 4040 6259 4920 324 1499 6714 51176 6422 22943 7008 PMC3024228__F1 General pathway for phosphatidylinositide (PI) synthesis 200576 5266 5728 PMC3025384__F3 Wnt signaling plays central role in embryogenesis and human diseases including cancers 1956 8717 7186 7189 581 596 572 1499 6908 2002 1386 3725 PMC3026473__F2 Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets 3667 8660 5163 664 PMC3026989__F1 The innate immune induction pathway through RLR activation 3665 3661 3456 PMC3027158__F8 Ingenuity network predicted for genes that were both hypomethylated and increased in expression in zebrafish HCC (shaded red) 1356 84654 4869 PMC3031560__F5 Identification of Novel Molecular Targets for Endometrial Cancer Using a Drill-Down LC-MS/MS Approach with iTRAQ 3190 6424 2243 350 2244 197 1622 336 PMC3032036__F10 The paracellular pathway in vertebrates and insects 999 3897 1499 23418 90952 434 10207 PMC3035824__F5 Mapk signaling pathway from KEGG 7975 1956 759 4149 PMC3035871__F2 Targeting Fas in osteoresorptive disorders 650 2050 6850 4086 4089 387 860 468 4772 3725 2353 4041 PMC3039745__F1 TRAF6 and A20 control K63-linked ubiquitination of Beclin 1 to trigger autophagy 7099 7189 596 PMC3039927__F1 Organellar Ca2+ buffering and intracellular Ca2+ dynamics 3270 762 84876 6786 PMC3042730__F2 Inflammatory signals regulate hematopoietic stem cells 3458 3455 3460 3454 3459 3716 7297 3717 4615 8717 6772 6773 7189 3550 10379 1386 7186 PMC3046044__F1 Molecular mechanisms involved in nasopharyngeal carcinoma (NPC) development 5728 85451 999 PMC3048914__F6 Differentially expressed genes in the MICs as compared to NSPCs 1499 7043 7076 6678 5728 355 1956 26762 4088 2313 6667 3479 1029 898 2118 1270 1950 PMC3049118__F6 Cardiovascular disease genes increase in the spleen of CVB3 infected males at 12 h pi 81579 10787 9532 4023 6387 2487 1233 5606 6932 3250 759 761 PMC3058199__F6 Noonan syndrome and clinically related disorders 3265 1431 3845 2885 867 6654 4047 5894 673 8036 161742 PMC3058380__F5 Focal adhesions in osteoneogenesis 2885 2534 4342 PMC3058926__F4 Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations 1387 999 5970 5971 7157 55602 1958 79800 27040 2318 PMC3059560__F1 Targeting the embryonic gene Cripto-1 in cancer and beyond 718 2821 4838 PMC3064425__F2 Dietary agents on the extrinsic and intrinsic pathways of apoptosis in prostate cancer 7124 355 581 8772 637 PMC3064843__F5 DNA Repair Deficiency and Neurological Disease 7508 7507 3980 3978 PMC3065826__F1 Metabolism, Cell Surface Organization, and Disease 2592 4247 4249 4245 51083 1956 PMC3068163__F1 Melanoma Molecular Disease Model 2776 2767 5728 4893 673 2475 4286 1021 1019 572 637 581 4193 PMC3069839__F5 Regulation of Atm pathway genes after Rif-Phen-MCT 472 11200 4193 3550 7157 3725 672 7161 PMC3070611__F4 One of experimental result from pathways intersection 1052 5900 6010 5728 5266 3280 388585 84083 PMC3070611__F5 The shortest pathway identified by our system 1052 1054 6647 PMC3075645__F8 DNA damage-triggered activation of SAPK/JNK at late times following cisplatin treatment 6010 7507 545 472 7508 675 PMC3077082__F1 Microbial manipulation of receptor crosstalk in innate immunity 634 8685 6850 3133 PMC3078187__F1 Signaling Cell Death from the Endoplasmic Reticulum Stress Response 83939 468 637 4170 581 PMC3081368__F8 HMGB factors are required for posterior digit development through integrating signaling pathway activities 3146 3148 1499 6469 PMC3081520__F4 Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease 10533 22863 9474 9140 8772 PMC3084093__F4 Proteins encoding the CAF and tumor stroma-associated genes from seven different epithelial tumors share common involvement in the MAPK signaling pathway and focal adhesion 6464 3676 5566 7450 7048 3688 1499 5154 5295 1956 7046 2064 60 7186 PMC3091517__F2 Ras/PI3K/PTEN/Akt/mTOR Pathway and Potential Sites of Therapeutic Intervention 2475 126669 2885 5728 4193 6009 64798 6194 1975 PMC3092918__F1 Metabolic network used for metabolic flux analysis 26035 51083 11113 4118 PMC3095674__F4 Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway 10454 7189 51295 6750 596 PMC3100780__F3 Integration of BMP, FGF and Wnt signalling at the level of Smad1 during neural induction 4040 4041 4086 PMC3103541__F8 Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex 1325 5728 2475 PMC3103888__F1 TIRs signaling pathway 10333 7100 7097 81793 7096 51284 7098 4615 29110 3654 3661 3569 PMC3107200__F8 Chk2 and p53 Are Haploinsufficient with Dependent and Independent Functions to Eliminate Cells after Telomere Loss 545 472 2922 6497 PMC3109223__F1 MTOR signaling pathway 5728 5163 7248 7249 6009 1499 1977 PMC3109507__F1 Choosing the right path: does DNA-PK help make the decision? 580 672 11284 641 9156 7515 7518 5888 675 79728 PMC3110886__F4 Functional analyses of differentially expressed predicted targets of significantly altered microRNAs 1356 6229 387 407019 406953 407050 407051 406991 8567 406979 PMC3111376__F9 Overrepresented miRNA regulatory pathways in PKD 554210 406902 574441 407029 406987 406983 407053 406958 PMC3114846__F5 Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases 55014 434 3205 340273 3820 22914 3238 1638 367 PMC3115327__F3 Scheme of the signal transduction pathway in response to DNA damage 472 84126 5810 1647 PMC3116645__F1 Mammalian target of rapamycin (mTOR) signaling pathway 3479 3667 5163 6009 2475 64223 253260 1977 PMC3116873__F1 Oncogenic CagA Promotes Gastric Cancer Risk via Activating ERK Signaling Pathways: A Nested Case-Control Study 6714 1398 1399 2885 PMC3118759__F5 Alteration to activity of the Akt/GSK3B signalling pathway can explain a number of the changes observed in microarray analysis of flies expressing rCAG, rCUG and rAUUCU repeats in the nervous system 627 4803 2932 3064 6310 367 4287 PMC312639__F9 Proposed model for RhoA signaling to the c-jun promoter 998 387 6010 PMC3128624__F6 NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease 4097 3727 23764 2353 79982 5970 7157 PMC3128635__F1 RAS signaling to the PI3K pathway 2885 5728 5163 3667 2475 253260 7249 572 PMC3129516__F2 SIRT3 and Cancer: Tumor Promoter or Suppressor? 10135 6648 23410 7226 PMC3131451__F1 The PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays 5163 5728 2475 27250 PMC3134408__F1 Proposed molecular pathways in arterial, venous and lymphatic specification in a developing embryo 2296 2303 83595 54345 26508 23462 23493 8828 2050 5629 PMC3136489__F7 Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood 3446 3569 3458 6772 6773 8554 6775 3659 2633 4599 8519 10437 10581 2537 3434 5696 4600 3669 64135 9636 2634 PMC3136711__F2 Qu on cell cycle 1017 1021 1019 PMC314152__F7 LMP1-induced canonical and noncanonical NFKB activation 3654 7186 5971 5966 7852 PMC3145778__F9 Redox-Induced Src Kinase and Caveolin-1 Signaling in TGFB1-Initiated SMAD2/3 Activation and PAI-1 Expression 6010 1956 5494 PMC3148653__F3 Network of TP53-regulated genes 6241 1839 5329 7378 5743 2181 890 3569 3161 23612 8795 4085 4318 3486 1026 6696 1062 64151 891 4751 27346 8794 9518 8061 1111 8870 7430 9133 7157 81620 51512 9055 3151 4436 699 10403 11065 7153 5427 4175 55872 PMC3148653__F4 Network of HNF4A-regulated genes 10062 50 83638 10625 9603 1545 5783 1999 9572 7424 2877 3172 22824 360 83719 5378 54623 6617 2342 54797 83540 3146 1386 2355 PMC3149150__F2 Regulation of STEP phosphorylation 3084 2066 2534 PMC3154366__F4 c-Myc regulates the rate limiting steps at the entry into glycolysis 130589 3098 3099 3101 2645 2821 5236 5238 5214 5213 5211 2203 8789 226 229 230 PMC3156249__F1 B-Myb, Cancer, Senescence, and MicroRNAs 1874 1017 6502 PMC3161159__F1 Retinoid metabolic pathway 9227 220 1592 340665 56603 5915 5914 PMC3163143__F3 Genomic and non-genomic actions of all-trans retinoic acid (ATRA) 8480 6502 999 102 351 PMC3163776__F2 IRE1Alpha-XBP1 pathway in inflammation 581 10605 7097 7099 7186 7189 7124 3569 PMC3164150__F2 Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway 3479 3481 3667 2885 7249 7248 5728 2475 572 PMC3164321__F1 KEAP1 Cullin-3 E3-ubiquitin ligase complex and its roles in maintaining cellular levels of NRF2 and IKBKB 9817 9978 8452 3551 PMC3164983__F1 mTOR inhibitors in renal cell carcinoma 1977 2475 253260 6009 5163 7249 7248 PMC3167192__F1 Molecular basics of tumor angiogenesis 2056 4843 2050 8205 5155 PMC3170087__F4 dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity 8772 3661 7187 PMC3171751__F3 Altered gene expression during pressure overload hypertrophy 8647 996 10538 355 7443 6774 1277 4026 4173 3550 1361 1326 5324 9518 9191 488 8870 6300 2774 3725 10148 5020 8674 1119 1395 6875 PMC3173057__F11 Schematic view of the proposed HSP60-TLR4 signaling in response to myocardial ischemia 7099 4615 8772 3654 PMC3174756__F6 CDK5 (A) and actin (B) signaling pathway in primary neurons 4803 4804 2354 1636 PMC3177572__F6 Schematic diagram summarizing the bidirectional role of PIAS1 in regulating JNK-dependent oxidative stress responses 7341 29843 8554 PMC3179880__F2 Functional role of skeletal muscle-derived neurotrophic factors after exercise 5979 627 2668 6009 2475 PMC3182762__F1 TLR signaling pathways 51135 7189 23118 3665 114609 PMC3185489__F2 Some of the effects brought about by HCV on insulin signaling in hepatocytes 3667 2475 5310 5311 PMC3185699__F1 Proposed signaling pathway to the actin cytoskeleton during HIV-1 entry in T lymphocytes 920 7852 3702 387 10013 PMC3185727__F1 Illustration of the endogenous RNAi pathway and therapeutic mimics 54487 29102 27161 PMC3188957__F4 Highest confidence network of genes influenced by CLOCK knockdown 7365 7366 7367 84168 4282 948 1113 6286 4248 PMC3190874__F1 Immunoglobulin E Receptor Signaling and Asthma 27040 2534 4067 3055 6850 5163 695 2475 PMC3192911__F2 Therapeutic tol-DC in organ allotransplantationTol DC can be either recipient- or donor-derived (in the case of living-donor transplantation) 3135 50943 324 PMC3194179__F2 Ingenuity Pathway Analysis identified ERK as the Top network signaling Hub where the shaded shapes indicate the candidate genes from the present study 2241 51199 9472 1500 5905 4248 114131 PMC3194179__F3 Ingenuity Pathway Analysis identified MapK as second Top network signaling Hub where the shaded shapes indicate the candidate genes from current study 1112 406926 2984 8728 6938 5660 7088 6929 285513 5079 23043 5307 1879 9901 8027 10788 111 PMC3194179__F4 Ingenuity Pathway Analysis identified NFKB as the Top Network signaling Hub where the shaded shapes indicate the candidate genes from the present study 135138 5607 1603 10392 3781 56479 27063 10133 6237 5924 6660 1501 6678 PMC3196095__F6 Proposed model 3929 7099 929 5465 PMC3196743__F2 The Contribution of Vitamin A to Autocrine Regulation of Fat Depots 688 2638 1050 PMC3196888__F8 A model showing the overlapping functions of MMR and FA proteins in ICL and MMR 545 5395 4292 4436 4437 PMC3201689__F1 Diagram illustrating the DNA base excision repair (BER) pathway 328 183 5423 2237 7515 3980 3978 PMC3203793__F6 Molecular modulation of peripheral myelination by the Sirt2/Par-3/aPKC pathway 22933 324 2932 PMC3203793__F1 Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling 324 2932 22933 PMC3206090__F5 Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development 3479 7248 2932 7249 2475 3064 5663 PMC3206195__F3 Fear Conditioning, Synaptic Plasticity, and the Amygdala: Implications for Posttraumatic Stress Disorder 627 10818 4280 PMC3210466__F1 MTOR signaling pathways 5728 27185 1977 7249 7248 6009 2475 253260 PMC3213765__F17 Wnt signaling pathway 8313 8312 324 1499 595 PMC3213765__F20 Shh and BMP signaling 6469 4613 3398 3397 474 4151 PMC3215281__F7 Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease 2237 4968 7507 5111 2067 PMC3218743__F2 Inflammation in the gouty joint 4615 545 114548 PMC3218904__F2 Network pathway analysis of down-regulated genes in the gene category mitotic cell cycle 994 995 899 2956 8317 5427 8243 699 8697 10403 10592 64151 10051 4751 5111 996 5422 23397 11065 22974 7272 6241 43 51512 1854 6790 3838 1063 404281 55872 4436 7157 675 22904 4609 586 8824 5558 83699 7728 5901 51053 6038 81570 5519 9700 60386 3172 9118 81558 51659 4133 6787 4750 26995 3619 1070 PMC3218933__F3 Embryonic pathway signaling leads to induction of epithelial-to-mesenchymal transition 54567 28514 10683 3714 182 6608 2736 6591 11279 7291 333929 117581 6935 999 1499 558 1950 PMC3222852__F2 GSK3 is a key regulator of axon growth and branching 2638 5728 324 1641 PMC3225503__F6 Pathway model based on vision related TMT-associated gene expression changes indicating a possible mechanism for TMT elicited neurobehavioral changes 1406 407 6010 PMC3227667__F3 Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis 1719 4522 160428 25902 123263 10840 2618 1757 6472 6470 29958 471 275 10797 PMC3227781__F2 Genomic and nongenomic vascular effects of estrogen 6714 4512 2638 387 PMC3229968__F1 Deciphering the role of Nuclear FactorKB in cellular senescence 4050 10454 5971 5970 PMC3231924__F1 Simplified scheme for TLR signaling in enterocytes 7096 7097 7099 54106 7100 114609 4615 7189 7098 64127 10392 7187 3550 3661 PMC3234195__F1 Petroleum diesel, biodiesel, and ethanol 1674 4018 5091 4099 PMC3235480__F2 RAF/MEK/ERK and the PI3K/AKT/mTOR signaling pathways are shown 2475 5728 572 PMC3235896__F2 Transdifferentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into the multiple skin component cells 5156 3146 1236 PMC3236061__F5 Cooperation of the genes in the DNA repair cluster 7015 5901 4171 26277 6118 4292 472 5932 5884 25 641 5976 4436 51053 990 8243 142 10111 4172 545 6117 5888 675 5429 4771 672 10926 7415 23237 5980 1029 7516 7518 2547 7517 7334 9156 3981 79184 1786 328 2071 2965 2968 5886 4331 2956 5378 5810 5981 604 25788 5423 5428 7320 7336 6996 54205 6418 2197 4913 324 4353 PMC3236328__F1 Main NFKB-activating pathways 7124 958 257397 23118 5971 7186 7187 PMC3236456__F2 Fungal cell wall pathogen-associated molecular patterns (PAMPs) and their host-pattern recognition receptors (PRRs) 7097 54106 10333 3603 PMC3237867__F1 Metabolic pathways, transport, and receptors of S1P 124976 55937 6010 PMC3238353__F1 ER stress and activation of the UPR signalling pathways 22926 1998 468 PMC3243049__F3 The autophagy pathway is affected at different steps in the various types of dementias 7415 25978 2475 PMC3243079__F2 Non-genomic ERA pathway 6714 2353 3725 PMC3245020__F3 Disease/drug mapping is the process to map all known disease genes (pink) and all known drug targets (light blue) against all KEGG pathway maps 351 23385 3416 4023 348 572 836 8772 637 6622 22926 7124 2932 840 PMC3248184__F1 YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention 6714 5163 2932 PMC3251842__F2 TGFB response pathway 693221 4087 4088 407009 7018 4089 999 PMC3255783__F7 Model depicting the potential roles of Hrq1 in NER-based lesion processing 7507 5111 51455 80198 PMC3259192__F2 Sphingolipid Signaling and Hematopoietic Malignancies: To the Rheostat and Beyond 6774 8877 572 581 51083 PMC3260452__F2 Simplified model of the leptin signaling pathway 4852 181 627 7200 4160 4159 5091 PMC3261822__F3 IPA-based pathway analysis of differential expressed genes 8754 3675 1109 7272 3709 6648 3669 652 5118 3710 1991 1545 51330 3043 9775 6304 4356 51129 51 1512 8320 65009 1471 10856 6944 50859 4609 85403 949 22936 1362 377 3651 9910 PMC3262999__F1 Interaction between Jak2/Stat5 signaling and the PI3K/Akt1 pathway in mammary epithelial cells 5617 5618 3717 6714 5163 5728 PMC3263561__F2 Interaction between glia and neurons may lead to neuron damage and death 3929 7099 929 PMC3263689__F2 VHL complex targets HIF-1A and HIF-2A for ubiquitin-mediated degradation 9978 7428 7039 1956 PMC3266783__F2 Basal cell carcinoma — molecular biology and potential new therapies 91653 2619 5727 64399 374654 6608 8405 2932 PMC3268617__F2 Dys–Syn–nNOS pathway and miRNAs coordinate the muscle differentiation program 2539 7528 2006 6722 3065 5081 5422 9759 PMC3269610__F2 BMP signaling and negative regulation in bone formation 50964 860 22943 9242 PMC3270101__F6 Pathway map related to cisplatin-induced hepatotoxicity based on proteomic and genomic analysis 4547 2194 2203 4191 51665 847 6648 338 383 384 2953 2939 10449 PMC3279615__F3 Nucleotide excision repair (NER) pathway 1362 7508 7507 5111 2067 PMC3280691__F1 Beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target 4040 4041 8313 8312 324 1499 PMC3286890__F1 Wnt/Beta-catenin signalling and Beta-catenin role in adhesion in glioma cells 324 1499 1956 1950 79923 PMC3288643__F1 Ephs and Ephrins in Cancer: Ephrin-A1 Signaling 1969 5728 5163 PMC3290617__F1 Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin 7097 3643 51135 3654 7189 6648 3667 8660 PMC3290818__F1 TLR signalling pathway 4615 7098 7099 114609 51135 23118 7189 7187 3661 PMC3291637__F1 General scheme for biogenesis of Fe-S clusters in mammalian cells 2242 23479 9054 80224 388962 27247 51218 PMC3291637__F2 Proposed differences in the localization of Fe-S cluster biogenesis proteins in S 27158 23479 4682 9391 22 27247 PMC3291787__F1b Targeting the EGFR signaling pathway in cancer therapy 7039 3273 685 367 1950 1839 PMC3291789__F1 Targeting the p53 signaling pathway in cancer therapy - The promises, challenges, and perils 4194 4193 581 1643 2176 1647 9997 3976 995 2876 27244 83667 57103 94241 355 4436 7508 64065 PMC3296768__F5 Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis 367 26136 2002 619509 6555 2353 6497 10763 5915 4897 PMC3303474__F3 Bibliosphere network of ubiquinol-sensitive genes regulated in liver tissues of C57BL6J mice 19 6720 6667 7018 57678 PMC3307959__F5 Unconventional roles of kinesins in cell signaling 2668 24137 2674 26153 2885 6608 11113 351 PMC3308858__F8 How GSK3B phosphorylation is involved with microtubule destabilization 1020 1400 2932 780904 PMC3310225__F10 Protein Kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development 54361 2253 1390 PMC3311240__F11 Muscle cell signaling in response to 1E3 998 2885 5163 50964 5879 5058 PMC3317213__F4 Metabolism of xenobiotics by cytochrome P450 pathway, and ribosome map views of identified proteins 3416 4025 6476 PMC3323758__F4 DNA base excision repair: A mechanism of trinucleotide repeat expansion 4968 2237 7143 5423 PMC3326558__F8 Schematic illustrating estrogen-dependent regulation of miRNA (miR)-34b expression, its target genes and tumor growth 8205 182 595 PMC3327653__F1 Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway 137964 4018 5091 4099 PMC3328211__F2 Arterial-venous and lymphatic specification in vertebrate embryo 8829 2303 2296 8828 23493 23462 64321 83595 54345 2050 PMC3328908__F9 Diagram of canonical tight junction signaling pathway 8205 100170220 100129193 59330 8573 100187761 759 5728 4099 PMC3329953__F8 mTOR pathway in aging 2932 7248 7249 6009 64223 2475 1977 1938 PMC3335081__F9 Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation 9242 23411 860 PMC3335396__F1 Ligand-dependent activation of the Hh pathway 6469 6608 5727 2735 PMC3336771__F1 Endogenous polyamines potentiate macrophage polarization 3566 383 7099 PMC3345255__F1 MAPK/ERK signaling and the hallmarks of cancers 1950 7124 2475 581 572 PMC3353781__F8 Signaling pathways mediating Beta-adrenergic effects on the cardiac microtubule network 5058 367 4134 PMC3356053__F10 Most significant canonical pathway from this study 1398 2885 4609 4149 79629 63923 PMC3359076__F5 Regulation of thrombin-induced RelA/p65 nuclear translocation by the Rho-actin pathway 387 3550 5970 3383 PMC3359119__F1 mTORC1 signaling and regulation of pancreatic Beta-cell mass 5163 5728 8491 7249 7248 6009 5898 2932 64798 2475 253260 29904 1975 1977 5465 3667 8660 PMC3360606__F1 Integrative Gene Regulatory Network Analysis Reveals Light-Induced Regional Gene Expression Phase Shift Programs in the Mouse Suprachiasmatic Nucleus 2353 3725 11072 4862 1408 2922 680 4829 7432 551 9575 PMC3360922__F1 Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances 495 7018 654 7036 3077 80762 148738 164656 3091 7428 57817 6776 6777 4830 2235 PMC3367861__F2 IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis 3575 3718 1948 1947 PMC3368374__F1 In young muscle, abundant serum IGF-I can stimulate protein synthesis by activating Akt/mTOR/p70S6K pathway 3717 4087 4088 7249 6009 2475 3479 8836 PMC3368988__F2 Sites of PP2A activity within the network of ERK activation 6714 5894 8844 PMC3373577__F4 Increased Levels of BAFF and APRIL Related to Human Active Pulmonary Tuberculosis 5966 1401 3458 7514 7187 4982 604 8764 958 5599 5970 5045 836 3172 4791 10342 6385 4792 355 959 7157 65078 7132 2207 4609 115650 2817 7124 3586 PMC3374592__F1 Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles 6714 2885 4609 PMC3374844__F1 Three major UPR pathways in metazoans 468 83939 22926 7494 PMC3378042__F2 Implications of Protein Post-translational Modifications in IBD 123228 8454 51667 7099 8772 3569 PMC3381938__F5 Alternative Macrophage Activation and Metabolism 3566 6778 355 383 PMC3382204__F5 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease 7124 7039 3569 1437 3563 3558 7423 1235 3624 5008 3625 1233 2324 83729 3082 3976 3815 3977 4049 650 4055 4050 355 6368 1441 1440 920 3952 3953 59067 1232 85480 11009 1896 10913 50615 4352 7173 PMC3382253__F3 Mitochondria are central organelles in determining cell fate in liver diseases 8772 637 581 317 2021 PMC3383194__F7 The mechanism through which PTPN22 blocks proapoptotic and enhances antiapoptotic BCR signals 933 613 4067 6850 29760 26191 5336 PMC3386525__F3 The signalling transduction pathways involving the tuberous sclerosis proteins, hamartin and tuberin 5163 5159 6009 2475 6010 1977 5163 6009 2475 6010 5159 PMC3388569__F2 Shared biological pathway activation between chemotherapeutic agent treatments 572 3350 324 2099 3356 4282 PMC3390419__F1 Caspases and Kinases in a Death Grip 355 8772 637 581 596 PMC3391249__F8 Defence Signalling Triggered by Flg22 and Harpin Is Integrated into a Different Stilbene Output in Vitis Cells 2312 9242 3240 PMC3392150__F1 Unfolded protein response and its role in intestinal homeostasis and inflammation 22926 7186 207 83939 85451 468 22809 PMC3392648__F1 Insulin signaling pathways 3643 5728 5163 2885 2932 572 PMC3393825__F1 Signaling the Mitochondrial Unfolded Protein Response 8192 27429 4899 PMC3399428__F2 “Hpo signaling pathway in Mammals and the cross-talk with RASFF1A signaling.” Schematic representation of mammalian Hippo kinases cascade and interconnections between Hippo pathway and rassf1a protein signal 4771 122786 60485 5894 4485 9113 26524 7008 355 PMC3400831__F5 PGI2signaling pathways in VSMCs 6502 387 4513 PMC3402068__F1 What Goes On Must Come Off: phosphatases gate-crash the DNA damage response 472 3014 9656 672 545 9156 6118 5888 675 7518 4193 80198 146956 84464 51750 PMC3403084__F5 Necrosis signaling pathways 7124 7186 8717 8772 1540 197259 PMC3404043__F3 Whole Transcriptome Analysis of the Effects of Type I Diabetes on Mouse Oocytes 5885 4089 4193 6502 9184 5266 5111 1022 1017 1869 10926 23041 3630 5447 367 1363 27040 5478 699 2020 9126 11113 PMC3405333__F10 ERK/MAPK signaling pathway 673 4342 572 1977 6722 PMC3405333__F11 P38 MAPK signaling pathway 7124 7186 7189 4149 11101 1386 6722 2002 PMC3408193__F9 Proposed protective pathway by E-LP against glutamate-induced apoptosis in RGCs 4035 2 5335 2932 PMC3411066__F6 Formation and function of 16:1-PI in the signaling of the lipokine 16:1 in Swiss 3T3 cells 355 137964 84803 150763 4018 5091 PMC3412259__F1 This diagram of BCR/CD19-initiated signaling shows two key outcomes of PI3K activation 613 930 5163 695 29760 6850 253260 2475 107966124 PMC3413017__F1 Apoptosis and necrosis 8772 472 581 4193 PMC3414439__F4 Combinatorial Drug Discovery Using Transcriptional Response Modules 859 3753 7153 836 5606 8569 5578 5595 2770 2934 6714 PMC3414447__F6 n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1 6361 27 5159 2887 7297 351 6925 2 2246 6997 1910 PMC3416758__F7 TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells 581 2353 1386 PMC3423785__F2 Functional analysis of the top-scoring network of AE9a dysregulated genes 199 3963 4664 351 1647 891 1536 1316 55165 4665 1523 4211 3956 3304 8609 1026 3045 100187828 1602 255488 5660 5583 4026 6710 51274 6272 240 2760 23225 PMC3423855__F1 Hepatocellular processing of, and immune modulation by, the precore protein 7097 942 4118 4615 PMC3425953__F1 Activity of Wnt canonical signaling pathway in the normal and tumor cells 2932 324 1499 4041 4040 1401 PMC3426783__F4 IPA network analyses were applied to differentially expressed genes in mouse brain after in vivo ketamine exposure 84676 374 5592 7139 3482 5266 7134 7140 4762 9240 4821 5078 3655 5705 79156 8861 116225 863 3172 6532 55119 92359 2906 2705 1595 2355 PMC3427262__F1 Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease 8678 9140 9474 468 83939 596 7186 2308 3479 8660 PMC3427704__F1 AID-associated gene network 27189 5079 959 604 6829 9242 6778 3398 7528 3662 3394 4193 118460 5393 11340 54512 51013 23404 23016 51010 56915 5591 58155 22894 7157 79923 3836 7155 7374 PMC3427885__F4 Impact of HCV infection on ILK signaling 5728 7016 2475 2157 6007 4513 2057 PMC3428657__F1 The signaling pathway ofGHRregulated by let-7b 3667 2690 9021 3953 3479 PMC3432190__F2 Concept of molecular network in schizophrenia 1956 3565 998 3067 9314 1644 207 5578 1633 920 435 81 7422 6714 382 4609 7054 1950 22978 5337 5359 2628 6925 4846 2335 5338 383 5319 5091 627 4803 445 4953 7356 1312 124 5306 5832 9227 217 5743 790 5625 5335 8659 4916 10623 PMC3433406__F5 Large scale phosphoproteome analysis of LNCaP human prostate cancer cells 1495 3482 4363 288 1207 22880 7165 9513 821 57532 6745 3895 1936 9100 4134 4627 3315 10146 23524 1499 6607 6606 1500 7112 3187 3066 65095 4176 4904 8449 4869 81608 10075 8683 9221 8570 10250 7158 6741 4926 7536 9656 9774 50804 54888 84991 1479 9967 7508 7090 5981 PMC3435458__F7 RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells 7124 8717 8772 6001 PMC3437546__F2 HIF target genes encode proteins involved in critical aspects of cancer progression 133 84076 226 5211 1906 7015 2056 2023 2821 7039 2597 3481 3939 5163 664 665 5155 284 285 3398 7431 6615 6591 1075 4313 9839 6929 4015 4318 4323 4017 5329 PMC3438084__F6 A subset of the up-regulated genes with known function in response to maize root exudates 5805 2580 48 PMC3439136__F4 Dynamics in the RTK-Ras-ERK signaling network 6167 6168 6147 PMC3443512__F8 TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN 1956 2475 27250 4582 PMC3445042__F7 The role of Wnt signaling in hypothalamic progenitor differentiation 6658 6657 1641 2670 3280 PMC3446651__F2 Viral proteins inhibit nucleic acid receptors of the intracytosolic innate immune response 57506 7189 29110 253868 729 3661 PMC3458820__F8 Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence of Increased 25-Hydroxyvitamin D3 Levels in Male Mice 4280 1594 1591 120227 PMC3460040__F8 Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib 84876 5894 673 6786 PMC3461086__F4 Simplified diagram of signal pathway convergence at downstream nuclear targets 6662 860 4089 PMC3461213__F1 Regulatory mechanisms of phosphate homeostasis 5741 8074 1758 5251 PMC3461213__F4 Overall picture of the physiology of FGF-23 and its role in phosphate homeostasis 8074 5741 1758 56955 5251 PMC3461959__F3 Blastocyst Lineage Segregation and Stem Cells 79923 6657 2627 64321 2626 PMC3463893__F2 The inductive and effector sites for the mucosal B-cell response in CD 2638 5091 613 958 PMC3465517__F5 Network analysis of proteins found to be significantly altered in abundance in the CSF proteome by ANOVA (p value <0.05) following analysis of individual subject samples 5950 3514 3500 2266 3273 5627 5345 1675 710 715 629 1435 2202 8404 63827 5265 6447 183 6696 2192 12 2199 7018 3489 1191 1356 1471 7857 5004 5005 333 3481 2 1114 3240 4969 2934 3075 1363 3339 93185 351 960 7070 1272 53616 6647 1509 2760 1508 3535 25 PMC3466369__F1 Emerging Roles for Cholesterol and Lipoproteins in Lung Disease 7099 7808 19 9619 3949 PMC3466441__F1 Peptide neuromodulation in invertebrate model systems 2020 2019 64146 PMC3475613__F2 Schematic illustrating metabolic pathways prominent in malignant cells 4609 2539 3417 3939 51660 25874 2271 3418 3099 4149 PMC3475760__F1 As a key downstream target of PI3K-mediated signaling pathway in response to extracellular stimuli such as growth factors through receptor tyrosine kinase (RTK), Akt plays an important role in regulation of diverse cellular processes 5163 5728 4193 PMC3481134__F7 PRb/E2F signaling pathway mediates three distinct arms of TGFB tumor-suppressive effects 1874 4088 5548 836 840 4089 PMC3483307__F5 Novel Genes and Pathways Modulated by Syndecan-1: Implications for the Proliferation and Cell-Cycle Regulation of Malignant Mesothelioma Cells 1634 7046 4060 7039 4087 4088 1017 633 5606 23213 5971 9653 4792 2885 4609 1950 1956 2353 1848 56940 3727 PMC3491089__F4 Schematic representation which shows possible mechanisms of action by D- and Gamma-tocopherol in multiple signaling pathways involved in mammary carcinogenesis 5728 581 9817 596 842 331 836 595 1021 1019 5111 PMC3492042__F8 MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains 5885 1445 6502 699 9184 5111 1017 1022 4661 4999 PMC3493339__F1 ERBB Pathway 1950 867 367 685 3725 126669 2475 572 PMC3493873__F1 TP53 mutation status-specific network of potential candidate driver genes shown based on their known and predicted functional interactions 107 3480 2065 2066 6416 2737 8945 115 3667 595 9915 5914 4137 596 7422 771 898 7157 367 993 9232 11065 1111 890 8651 51512 891 5347 699 1956 3091 1869 PMC3494767__F5 Synergistic cancer cell death in response to stress when TSC2, but not Pten is inactivated in the context of a deregulated Rb pathway 5728 595 7249 7248 PMC3495118__F1 Transcriptional regulation of the cytoprotective phase 2 genes under control of the transcriptional factor nuclear factor-E2 p45-related factor 2 (Nrf2) 6420 1431 8452 9817 PMC3497051__F4 Autophagy process 8408 2475 9140 10533 83734 9474 64422 PMC3499061__F2 Schematic illustrations of the two significant pathways in the genome-wide gene self-reported asbestos exposure interaction analysis 961 355 2195 1956 8772 790 637 8213 331 6892 821 1520 920 4261 PMC3499080__F2 Alterations in the NRF2 canonical pathway in livers of mice treated with TMHF 9817 2495 7295 7415 10963 10961 10574 2052 847 5052 2729 2877 2730 2936 2512 9097 5479 2326 873 7314 316 8192 2289 PMC3499189__F3 Aberrations of PI3K-Akt-mTORC1 signaling pathway in prostate cancer 3479 3480 3667 5728 5163 7249 7248 27040 6009 PMC3499997__F2 Main therapeutic targets along the BCR signaling pathway in CLL cells 613 933 4067 695 6850 5336 29760 26191 PMC3500850__F4 Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response 2936 2745 3099 230 5226 3939 PMC3501223__F1 Role of Esrrb in ESC self-renewal and reprogramming 2103 79923 6929 3976 8202 6657 57167 PMC3508164__F12 Proposed model of Cripto-1 modulation of the Wnt/Beta-catenin signaling pathway 22943 89780 4041 2932 324 1499 PMC3509664__F3 PKR and the Insulin signaling pathway 8660 3667 2475 1977 7249 PMC3509664__F7 HCV and induction of the innate immune response 7098 57506 7706 3661 PMC3510826__F8 Important roles of SFKs in G protein-coupled receptor-induced platelet activation 387 717 5908 PMC3513735__F3 Most enriched molecular networks showing interactions between the significant genes (according to SAM)—(a) FOSB, ERK, MAPK3, CYR61, and the RAS-genes; (b) DUSP1, ERK1/2, P38MAPK, DUSP9, and RASD1; (c) CYR61 and NFRKB 291 54101 388 613 2886 2354 171177 1831 58480 126669 8440 9180 7984 1852 23644 7538 6672 23635 11252 4798 54058 7424 9697 PMC3514351__F1 Ingenuity pathways analysis summary 8320 1363 5551 5126 10525 5179 3902 3991 1356 10961 PMC3516830__F2 Interaction loop between the EGFR signaling pathway and miR-221/222 expression in the modulation of cellular processes 1956 2885 5728 2475 572 7227 7078 9839 PMC3518467__F1 Fast, Potent Pharmacological Expansion of Endogenous Hes3+/Sox2+ Cells in the Adult Mouse and Rat Hippocampus 2670 6774 2475 390992 PMC3518570__F2 Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease 627 2247 2668 650 PMC3520003__F1 Simplified summary of the role of ATGL in macrophages.FFAs which are taken up by macrophages are incorporated into TGs (and cholesteryl esters) 4023 5879 387 998 7038 PMC3523565__F1 Simplified scheme of the mitogen-activated protein kinase (MAPK) (RAS-RAF-MEK-ERK) signaling pathway.Notes:BRAF and NRAS are the most commonly mutated oncogenes in melanoma 5159 3480 4893 5728 369 673 2475 PMC3523810__F7 Possible inflammatory signaling pathway that results from the functional associations of the identified inflammation-related proteins (marked with an underline), which is regulated by acupuncture in asthma 6279 6280 6010 PMC3524152__F2 Bacterial effector targets the TRAF6-NFKB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells 10454 23118 7189 8915 10892 PMC3524227__F1 Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells 4170 637 581 PMC3525180__F3 Some perifosine-specific genes are connected by common pathways leading to MAPK signalling pathway and apoptosis 8777 4776 3480 7867 1386 PMC3526371__F1 NFKB activation in pathogenesis and therapy of cancer 1956 4050 3845 4615 7189 7186 5163 5728 5970 PMC3530456__F5 Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis 5359 135250 11025 50856 11006 23209 6932 2326 8743 5332 7306 864 1755 10457 5660 10320 6556 558 54209 1501 1230 1051 10628 4488 5045 51299 2260 10261 4046 10023 23089 8817 283120 4060 4826 5172 2706 8537 1601 158038 84898 3749 3768 2203 5213 744 PMC3532050__F1 NFKB inhibition by A20 in the TNFR1 signaling pathway 7124 7186 7188 8717 8887 26994 83737 5970 PMC3535184__F4 Ingenuity pathway analysis reveals the close relationship between 14 of 17 of most relevant genes in rectal cancer 64386 9076 1365 4313 55722 8519 8817 54829 3507 5226 7124 2523 1050 10924 9518 2118 4208 4151 9499 9068 57761 PMC3537922__F1 Unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses 958 7099 7098 7187 7189 10010 29110 81622 3661 929 114609 4615 PMC3541267__F3 Signaling pathways driving mesenchymal stem cells to differentiate into lineages found in reparative disorders 7480 81029 6259 7046 1499 PMC3544185__F6 Complex Patterns of Altered MicroRNA Expression during the Adenoma-Adenocarcinoma Sequence for Microsatellite-Stable Colorectal Cancer 693202 5624 324 6288 8454 6500 399 9475 759 PMC3545710__F5 Suggested pathway 6774 5292 4772 PMC3545835__F1 Principal platelet membrane receptors and signal transduction pathways 7450 5336 6850 PMC3548426__F1 Telomere syndromes 7015 55505 55651 1200 25913 54433 100134934 79991 80169 PMC3549317__F1 Lipid synthesis in yeast 95 5183 5091 PMC3551738__F3 Network analysis of known SLE-associated genes 721 717 713 712 1401 7332 7128 10318 7189 639 3663 7292 3654 4204 2214 2212 2213 2209 7297 640 6775 2113 55024 PMC3553500__F7 NleB, a bacterial effector with glycosyltransferase activity targets GADPH function to inhibit NFKB activation 7124 8717 7186 2597 23118 10454 PMC3556575__F5 Pathways of relationships identified by feeding gene expression patterns identified in erythroid progenitors to the Ingenuity software 7027 10963 9833 4149 4601 25937 5732 79980 5606 3087 7029 10036 4092 7678 4152 5933 1454 2022 7422 80310 64750 6498 4999 990 1063 8445 2171 1116 84515 4176 4173 4174 57178 865 26509 23001 9619 22807 1690 7188 997 57471 2624 55852 5905 10957 7127 56992 3098 3029 7390 3045 100187828 28996 51218 1371 210 2313 PMC3560666__F7 Pathway in MAS and differentially expressed genes: as shown in Figure, IGSF4, PTPRC (CD45) and CD3D belong to a family of cell surface adhesion molecules 8178 100133941 330 566 1437 1435 4353 915 5788 3045 100187828 7173 23624 301 290 3553 10666 57448 60675 598 1445 PMC3563076__F2 Molecules involved during pancreatic development 5456 3169 3651 389692 3170 256297 6662 50674 2247 9427 5078 79629 PMC3565545__F10 CHEK kinase pathway showing the role of CHEK proteins in cell cycle checkpoint control, and crosstalk with other pathways notably the P53 and BRCA pathways.Notes: Double circles indicate complex interactions involving multiple genes 5810 545 3364 10111 472 672 993 995 5111 1017 PMC3565545__F9 BRCA pathway showing the role of BRCA1 in DNA damage response and crosstalk with other biological pathways, notably the P53 pathway.Notes: Double circles indicate complex interactions involving multiple genes 84126 545 472 3458 9656 6772 580 466 571 641 5347 4436 4292 2956 10111 4361 PMC3565579__F1 Proposed mechanism for opioid modulation for TLR 3929 920 7098 29110 3661 7096 7097 10333 114609 7099 PMC3569837__F2 Understanding metabolic regulation and its influence on cell physiology 2539 5226 57103 5210 2147 9817 PMC3571113__F1 Six important signaling networks of osteoblast differentiation 2247 50964 650 4041 102725541 324 1749 847 3726 860 23314 468 387 2050 PMC3573709__F3 Protein-protein interaction network of NFY and associated genes 907 4678 7374 4436 4609 PMC3578033__F2 Inflammation and Diabetes-Accelerated Atherosclerosis: Myeloid Cell Mediators 4015 5228 5226 2180 10270 11216 11215 5091 PMC3578987__F2 MITOCHONDRIAL GLUTATHIONE: FEATURES, REGULATION AND ROLE IN DISEASE 7124 355 637 7390 PMC3583555__F2 Regulation of apoptosis by several pathways 6242 3690 581 PMC3583581__F4 Recent advances in prostate development and links to prostatic diseases 6469 3169 367 5728 PMC3585130__F1 The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network 1938 1801 1802 285381 51611 PMC3585130__F2 Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network 1801 1802 51611 51056 54820 92715 89978 PMC3585940__F5 Gene Expression Profile Analysis of Type 2 Diabetic Mouse Liver 948 5465 79071 2645 1374 1376 1962 5313 5836 2203 5105 355 PMC3587991__F1 P53 signaling pathway interacts with chromatin-remodeling factors in response to DNA damage 23411 57634 3065 9112 672 PMC3587991__F2 Chromatin-remodeling factors affect the cell cycle 472 3098 3099 10734 8243 9126 1108 PMC3588076__F2 mTOR signalling pathway 5728 2475 64798 64223 253260 5163 7249 7248 6009 8408 1977 PMC3588179__F4 The mechanism of IDO1 regulation on viral infectious diseases 5132 3620 2475 PMC3590201__F3 Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations 90550 5481 858 613 PMC3590494__F4 Significant molecular network of combination therapy related metabolites 6497 51199 9317 PMC3590661__F1 Schematic overview of the impact of HDACi on DSB signalling, HR and NHEJ DNA repair pathways 5888 472 10111 4361 672 675 3014 PMC3593087__F1 Pro-osteoblastogenic signal transduction by insulin and IGF1 receptors 3479 2549 2885 5728 PMC3594038__F1 Btk activates antiapoptotic pathways 695 4193 572 PMC3594407__F8 Signaling pathway by which Beta-catenin may regulate intricate inflammatory responses in liver IRI 2932 6774 5728 3661 3930 PMC3597092__F3 Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR 6822 7363 1581 355 570 9965 PMC3606591__F1 Novel approaches to inhibitor design for the p110B PI 3-kinase 7006 100124696 6010 5728 PMC3615902__F3 Developmental data alters disease mechanism prediction 10563 699 9787 7291 1058 332 3872 983 1033 22943 117 11004 3479 3308 2810 9212 4288 55872 9493 4751 2167 5069 81620 56992 3976 991 116 3507 22974 990 5265 5320 1081 993 701 3958 6401 995 55388 3624 9133 3161 7177 1062 3514 64499 2069 9156 1080 83540 1063 PMC3616322__F2 Signalling regulation of mammalian autophagy 5163 3667 8660 2885 5728 7248 7249 6009 PMC3621409__F5 Evolution of mirrregulation 1956 23152 1950 PMC3625183__F7 Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells 283871 387 23440 PMC3625357__F11 IPA-generated gene network linking 88 of 445 genes shown by microarray analysis to be significantly (P < 0.01) up- (blue) or down- (red) regulated >twofold in bovine TCs in response to BMP6 treatment 1583 3623 1909 1889 9495 8553 108 26136 3283 1906 1000 2516 6770 84707 4804 3973 4684 4257 4047 2263 3640 4739 3164 3398 9590 2194 3280 57678 19 26286 3397 664 5743 7052 3399 6364 9507 27289 6352 4843 6462 1718 5055 4303 4602 9314 3569 2199 1462 5054 7422 3157 9510 7704 10333 5327 5270 4312 6591 5329 1410 3248 7123 3553 12 3875 9902 4053 4071 3939 10516 51129 5325 PMC3627976__F1 The polyamine pathway 262 6723 6303 6611 PMC3630363__F8 Temporal restriction of the Cdk1/Cdc5/Mus81 pathway outside S phase is important for genome integrity 56852 80198 983 PMC3631012__F1 Mi-2/NuRD complex making inroads into DNA-damage response pathway 9112 54617 4193 545 3066 64326 3014 5111 PMC3631177__F2 Expression of Glyceraldehyde-3-Phosphate Dehydrogenase Associated Cell Cycle (GACC) Genes Correlates with Cancer Stage and Poor Survival in Patients with Solid Tumors 2821 2203 226 PMC3632658__F1 Interplay between viruses and host mRNA degradation 5073 27258 25804 51690 57819 11157 23658 27257 167227 28960 4256 54464 6041 57762 PMC3634825__F2 Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes 8646 9241 650 268 3398 3423 269 3400 659 5594 9978 8454 7057 7124 6500 57154 4087 5933 64750 7040 7042 7046 7059 1874 4088 4609 1634 1616 2033 6093 387 5515 5516 10637 7044 3624 3626 93 10468 83729 4092 4838 PMC3639322__F3a Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis 5465 3952 32 83737 2645 5468 7169 2167 1384 55937 11343 63924 2634 6720 PMC3639655__F4 Schematic depiction of c-Myc functional interactions with other pathways (for full discussion, see section Induction–Reversion Tumorigenesis in Animal Models by Oncogene-Driven Cancer Network Formation) 4609 1019 4193 1869 1017 1021 PMC3640296__F2 Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches 3099 960 7852 1499 3611 6774 PMC3640296__F3 Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches 1499 6774 2475 3611 7852 3479 PMC3640510__F2 Diagram representing possible mechanisms linking HCV-induced oxidative stress with hepatocarcinogenesis 79661 5465 1718 4193 PMC3641677__F4 Mechanisms that Regulate Stem Cell Aging and Life Span 3479 3480 5728 7248 7249 6009 1977 PMC3645912__F1 Induction and maintenance of IDO in dendritic cells 196 6774 50943 9235 2309 941 940 PMC3646677__F1 B-Raf protein and signaling pathways 1956 2322 2885 673 2475 4134 4133 4286 1378 1380 PMC3647990__F9 Model for Rrp1 regulation of chitobiose metabolism in B 4118 3098 8568 PMC3652804__F1 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity 3479 3630 3643 3485 3489 3488 3486 3484 3487 2688 2690 2692 6464 8471 3667 8660 5728 5295 5291 5290 5170 207 208 10000 PMC3653035__F1 Beta-Catenin plays two main functions in the cell 4040 4041 1499 324 51176 PMC3653120__F4 Effect of physical activity and obesity on the growth and development of colon carcinogenesis 7124 2932 1499 4609 5111 PMC3653945__F6 Toll-Like Receptor -1, -2, and -6 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis 7096 7097 10333 114609 4615 51135 3654 7189 3725 2353 PMC3654375__F2a Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning 2534 1020 5879 387 PMC3655867__F2 Leptin deficiency disturbs the insulin signaling pathway JAK2/IRS/PI3K/AKT/AMPK and triggers diabetes 3717 6774 9021 PMC3656404__F1 Signaling pathways involving PKR-mediated inflammation and immune regulation 7124 83939 9447 58484 1386 3661 3146 PMC3659082__F7 Insulin/IGF-1 Signaling, including Class II/III PI3Ks, Beta-Arrestin and SGK-1, Is Required in C. elegans to Maintain Pharyngeal Muscle Performance during Starvation 878 57578 5163 207 PMC3665230__F6 Pathway members of insulin/Akt signalling, TGFB, wnt signalling and inflammatory pathways that were regulated by prednisolone in 3T3-L1 cells 7042 5728 4088 26585 4170 5159 1958 3569 51176 1843 3398 27123 6354 3627 8322 2535 8321 6374 7474 7855 6423 PMC3667593__F5 Abbreviated Pluripotent Cell Cycle 1017 1021 1019 6667 983 7528 25988 466 3660 PMC3667651__F3 Mechanisms underlying molecularly targeted therapeutics-induced cardiac toxicity 3084 5163 6714 PMC3669657__F6 Observed effects of Hedgehog and Wnt inhibition, and Sox17 overexpression in HOG cells 50846 6469 3549 6422 6608 51684 6925 1499 64321 595 4040 4041 PMC3670293__F1 JAK-STAT pathway in hypertrophic stress signaling and genomic stress response 3717 6774 3976 PMC3674144__F1 New look at TCR signaling to NFKB 940 5163 8915 1540 10892 142678 5971 7189 7186 9454 PMC3675657__F7 Mechanisms for iron-dependent and iron-independent IRP2 regulation 9978 8454 983 6500 8556 26234 PMC3675828__F3 Abundance distribution of cell cycle proteins 9184 5810 5884 699 10940 4360 100188802 324 10297 27068 9978 6500 4999 23595 5001 553115 5885 PMC3678388__F1 Canonical ATR signaling pathway and functions of newly identified regulators.(A) ATR signaling is activated in response to single-stranded DNA gaps in the genome 84126 11073 545 571 637 988 990 22897 51550 91442 57697 4175 4173 4171 PMC3678415__F1 HDL metabolic pathways and current drugs under development 64241 64240 19 3949 3931 1071 7038 5360 53369 PMC3678724__F1 Alterations of the AKT pathway in human cancer 5163 5728 4763 7249 6009 4193 572 7248 7428 51230 595 1977 PMC3679459__F1 TRAIL apoptotic pathway 8772 596 581 637 PMC3680226__F6 Analysis and Prediction of Pathways in HeLa Cells by Integrating Biological Levels of Organization with Systems-Biology Approaches 472 5879 387 1386 PMC3680431__F7 Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties 2638 3553 7099 4312 7097 948 PMC3684135__F1 Transforming growth factor B (TGFB) signaling pathway in hypothermia 3694 7040 4052 7057 7049 2022 3624 10468 652 9241 7048 7046 6696 860 2280 25805 864 4087 4086 4090 4088 7481 4093 3976 3716 6774 4091 5601 3725 4089 7124 4092 8928 3458 5595 4790 1387 1950 5054 6498 2353 6497 PMC3685413__F2 SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia 929 6259 51135 1499 2072 2175 9759 4438 85417 4609 57680 1387 7514 8405 53981 PMC3690396__F7 Regulation of the Hippo pathway by cAMP-PKA signaling 60485 6010 4485 9113 26524 PMC3690774__F5 Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17Beta-estradiol in embryonic zebrafish 474 6608 7442 367 26160 4131 5624 PMC3692518__F4 miRNA Signature of Mouse Helper T Cell Hyper-Proliferation 2885 3932 3265 1445 10252 10253 5058 2002 23035 27040 PMC3693464__F1 Transcriptional Control of Cellular Metabolism by mTOR Signaling 5728 4763 1956 472 6009 7249 7248 PMC3695482__F2 Focus on Histone variant H2AX: to be or not to be 10111 4361 472 672 79728 675 3014 7518 PMC3696504__F1 Relationship between metabolism and the autophagy machinery during the innate immune response 7405 9140 10533 83734 64422 9474 7939 3565 3596 3458 3091 6778 3606 3569 3586 PMC3703536__F5 Highlights of 10 years of immunology in Nature Reviews Immunology 7097 7099 5894 6850 4615 64127 54106 7098 7187 3458 1843 6774 PMC3706521__F3 Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation 3562 2885 5478 56616 572 9846 3725 2002 5970 3565 1956 355 6667 7015 3479 3929 929 5058 PMC3706521__F4 Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation 4318 7422 948 961 3791 7039 2885 4803 998 PMC3706856__F2 The Effect of Curcumin on Breast Cancer Cells 1499 595 5111 581 2146 PMC3708179__F8 Enrichment of hyper- and hypophosphorylated peptides in the ERK/MAPK signaling pathway in the phosphoproteome of murine liver on treatment with high-fat versus low-fat diet 2885 1398 2534 6714 4342 7444 572 1977 4609 2002 4772 6722 PMC3711139__F4 Preparation of Dihydrothieno- and Dihydrofuranopyrimidines 7523 91653 367 PMC371122__F7 Signaling pathway of UCP1 transcription in brown fat 1386 108348018 7350 6256 PMC3712669__F1 The estrogen metabolic pathway is depicted 1733 1312 1576 PMC3712869__F4 Smooth Muscle Differentiation and Patterning in the Urinary Bladder 6722 652 6469 6608 2736 2294 2300 2299 PMC3713637__F4 Transcriptional regulation network centered on SP1 involves many genes of interest from pathways enriched in memory impairment 2534 23236 5331 348 88 5330 6667 5595 3688 5879 805 808 801 1385 814 PMC3713775__F2 MicroRNA and Signal Transduction Pathways in Tumor Radiation Response 10111 545 4361 9656 3014 472 5888 5893 675 672 PMC3714282__F1 Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway 7054 367 4350 PMC3717870__F4 Analysis of gene transcription in response to an acute bout of exercise identifies dysregulation of SMAD, CREB, and HDAC activity in LRT 1839 5054 10272 10512 6422 10253 388 5447 7177 27063 3308 596 4616 4088 4084 1026 6498 1958 2353 10891 467 3164 2138 1385 7832 466 4665 1649 90007 1959 64651 29950 1647 8013 PMC3718392__F1 mTORC1 signaling 5163 5728 3667 7249 7248 6009 PMC3720830__F7 Cytochrome P450 1A1 Regulates Breast Cancer Cell Proliferation and Survival 7248 7249 6009 2475 PMC3721034__F2 MDM2-p53 pathway revisited 472 1877 28996 581 9997 57103 PMC3721080__F6 Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks 768206 5581 6247 7124 140821 8660 5447 2475 717 PMC3721332__F2 Interactions between nTreg (A) or IL-2 activated inducible Treg (Tr1) with effector T cells (Teff) mediated by the adenosine and PGE2 pathways 920 50943 4513 PMC3724940__F5 Transcriptomic Analysis of Insulin-Sensitive Tissues from Anti-Diabetic Drug Treated ZDF Rats, a T2DM Animal Model 2110 25932 1339 9377 1351 4726 7388 4722 1329 374291 4728 1537 27089 1337 4706 1347 3420 4714 64981 6183 51079 4712 3032 4708 4713 51142 2170 3030 4702 400916 65991 84303 131474 93973 56943 6363 6944 55553 10563 6387 3843 PMC3726197__F1 Signaling axis exploited in the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutant mouse model of prostate tumorigenesis 5728 367 572 2475 PMC3728269__F1 Signaling pathways in melanoma.Notes: Oncoprotein Ras activates both the MAPK and PI3K/Akt survival pathways 673 6774 2002 PMC3728801__F1 Canonical and non-canonical NFKB pathways 5970 5971 100187761 9118 PMC3728834__F7 Proposed model illustrating the effects of reduced TH in thyroid cancer development in ThrbPV/PV-PTU mice 5728 2932 7068 PMC3729218__F4 Mutations causing susceptibility to intestinal inflammation 4583 360 22926 7494 286451 1956 2069 54106 374 PMC3729926__F6 Aldose Reductase Inhibition Enhances TRAIL-Induced Human Colon Cancer Cell Apoptosis through AKT/FOXO3a-dependent upregulation of Death Receptors 8772 637 596 581 331 PMC3739200__F1 Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway 627 2885 5894 PMC3739939__F4 Pathway analysis showing integration between signaling pathways, transcription factors, and adhesion genes 7431 100506658 117581 7291 4286 6935 9839 6663 6615 6591 PMC3741132__F1 Application of Artificial Neural Networks to Investigate One-Carbon Metabolism in Alzheimer’s Disease and Healthy Matched Individuals 5981 875 4552 4548 4524 2618 7298 PMC3742223__F1 Ageing-dependent decline in thyroid activity, leading to compensatory increases in cellular D1 activity and thyroid hormone metabolites that may, through non-genomic pathways, be involved in amelioration of ageing related metabolic disturbances 23411 3643 3630 7216 55364 PMC3742248__F2 Role of miR-302 during human ESCs (hESC) neural differentiation 10637 7044 4838 79923 6657 6929 7026 PMC3742302__F6 Omics-Based Molecular Target and Biomarker Identification 472 545 4193 994 995 PMC3742913__F5 Gene pathways revealed by comprehensive genomic profiling 836 4615 57580 1230 7099 4688 317 841 837 8772 10333 729230 1232 6850 835 842 7409 1233 1234 2268 3662 1236 834 7852 2833 10803 6774 8717 3603 3055 7124 8462 3656 3654 847 7186 6372 3627 11009 58191 7189 2099 7416 2919 284340 6667 3383 6387 6647 142 4313 920 3932 3716 50808 3976 3717 5008 3578 3569 4088 8660 3718 3565 3566 9021 6778 919 8651 7048 3558 3659 51135 4090 3265 338376 7046 5347 864 1958 649 1019 2309 6773 6714 4086 3663 861 3678 860 7077 960 2274 3688 4325 4323 2335 4321 PMC3743503__F8 GeneGo pathway map translation regulation of eIF2 activity 1950 1956 2885 9451 27102 3265 1965 8893 1998 8445 PMC3743503__F9 Evidence for indirect influence of kinases on tau phosphorylation 27102 9451 1263 5606 6667 1017 2099 PMC3744328__F1 Sumoylation and regulation of cardiac gene expression 10055 5905 3065 7508 1788 PMC3745216__F3 TGFB signalling pathway 9817 9978 8452 4088 6500 8454 8945 4089 999 PMC3748736__F1 Hippo pathway in Drosophila (a) and mammals (b) 8642 54798 23418 92359 286204 122786 4771 4485 26524 2736 374 PMC3748992__F5 Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma 2335 5881 55970 2768 4478 4286 7306 1638 810 PMC3751038__F2 T-cell death during HIV-1 infection 920 355 7852 8772 637 581 PMC3757375__F1 Signal Transduction Pathways controlled by the activation of epidermal growth factor receptors (EGFR) 1956 1839 7039 1950 PMC3757665__F2 Nrf2-Keap1 signaling pathway 8452 8454 3162 PMC3759859__F3 p53-induced cell cycle control and apoptosis 472 545 4193 581 PMC3759924__F2 Lin28/let-7 regulatory axis 4440 29102 54487 79670 23318 3643 8660 208 253260 595 896 1019 8091 PMC3762301__F3 Molecular inhibitory mechanism of cPAP to block proliferation and survival of prostate cells 2064 5894 3006 367 PMC3762672__F1 PI3-K signaling.Notes: Activation of class I PI3-K via RTK phosphorylates and activates downstream target PDK1, in turn phosphorylating AKT kinases at the threonine site 5163 5728 7248 7249 6009 1977 6194 PMC3770140__F2 PHLPP suppresses the PI3K/Akt signalling pathway 5728 2475 4485 PMC3770300__F1 Computational framework of 3D vascularized bone regeneration within a porous biodegradable CaP scaffold 650 860 9242 PMC3770777__F5 Schematic description of the metabolic network proposed to link DFMO-mediated inhibition of polyamine synthesis to observed perturbations in the methionine cycle, trans-sulfuration pathway, purine synthesis/salvage and de novo thymidine production 10588 4524 6470 4397 PMC3772092__F7 Cadherin 6 Is a New RUNX2 Target in TGFB Signalling Pathway 6615 3397 860 6591 2335 1014 7431 3371 1004 7018 PMC3773046__F1 Reducing Sphingolipid Synthesis Orchestrates Global Changes to Extend Yeast Lifespan 2273 11201 4693 PMC3774688__F1 Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis 5791 5788 9846 1398 27040 120892 914 6714 4082 10097 119 664 958 4057 2920 8837 1311 8764 10135 6347 4170 4210 28951 84824 PMC3774995__F2 Schematic representation of p30 functions 7099 1017 4609 472 PMC3775123__F1 Signaling modules responsible for autophagy-lysosome pathway in the adult 79594 664 665 64422 10533 83734 11337 9140 9474 65018 57724 7942 PMC3777492__F1 IGFBP5 enters cells through its own surface receptor or by freely diffusing into the cytoplasm 6469 6010 5894 3479 3488 PMC3778921__F4 Integrative Analysis Reveals an Outcome-associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B-cell Lymphoma 355 1029 23135 581 637 83596 4193 4194 6154 596 64065 896 1021 1017 983 1019 5934 5925 7027 7029 PMC3780472__F2 Biochemical changes during EMT in fibrosis 6935 9839 1000 999 PMC3783160__F4 Model of the interactions of Rrp1 and Rrp2 with the mediators of two branches of HR DNA repair pathway and helicases Rqh1 and Srs2 5888 119392 375757 80198 118027463 8568 2638 PMC3786590__F1 Simple molecular pathway for sex determination in the mammalian gonads 284654 6736 7536 6662 2254 10468 268 50846 PMC3787923__F2 The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer 1956 5728 5594 2475 PMC3789264__F6 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) parietal cortex (pCx) 9805 140467 23505 64756 65010 2033 79366 55154 309 7431 9823 PMC3789264__F7 Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) cerebellum (Cb) 9789 9782 1808 152137 11332 5354 203068 2597 4155 7431 57732 10067 54899 1465 6572 2934 79026 PMC3789264__F8 Brain site-specific proteome changes in aging-related dementia 351 1020 79026 51286 7143 1191 2782 7316 2932 PMC3795998__F1 Signaling pathways of the UPR in response to ER-stress 22926 83939 7494 468 PMC3797786__F3 Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells 440 10020 7372 339 2235 33 25796 957 4833 5579 5580 124583 7083 1593 4832 203 955 7371 6241 5214 7172 4708 5110 31 2869 875 54498 132 6611 2820 5095 84693 2628 353 100 1719 5625 4553 29920 2548 25973 10667 10056 PMC3798821__F6 The ILK signaling and its putative regulation by the micro-RNA-1 (miR-1) 55742 3611 6591 2335 595 4609 PMC3798933__F2 Insulin signaling pathways are inhibited by damage-associated molecular pattern (DAMP)-mediated, Toll-like receptor (TLR)-mediated pathways 7096 7097 7099 10333 3667 8660 4615 5266 7189 7187 9021 3661 PMC3799205__F1 The leptin-induced pathways 9021 3717 2885 2475 6774 1958 PMC3800035__F7 Heterotrimeric G-Protein, GA16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer 1499 7476 89780 4040 4920 4919 PMC3800594__F2 Schematic model of novel cytoprotective mechanisms in response to oxidative stress in Beta-thalassemic (Beta-thal) erythroid precursors 468 83939 7001 PMC3806315__F4 Serine, glycine and the one-carbon cycle: cancer metabolism in full circle 26227 157739 27232 2731 262 PMC3812255__F2 Serotonin Gene Variants are Unlikely to Play a Significant Role in the Pathogenesis of the Sudden Infant Death Syndrome 54738 121278 3064 140805 PMC3814363__F4 Structure-based phylogenetic tree of ATPase enzymes 10111 1080 166785 439 11144 26610 6010 PMC3816228__F2 Receptors involved in allergen recognition and uptake by AECs 7099 6364 6850 85480 1956 999 PMC3816662__F1 PI3K/Akt/mTOR signaling pathway 5728 64223 253260 5163 2475 572 7249 4193 7248 6009 4609 595 596 1977 PMC3822825__F2 E2F1-induced apoptosis 1869 317 4193 545 472 PMC3823597__F7 Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes 3339 302 5155 4352 7124 10272 PMC3823599__F7 MiR-103 Controls Milk Fat Accumulation in Goat (Capra hircus) Mammary Gland during Lactation 2180 2194 4023 31 9619 51 948 6319 19 8694 PMC3824607__F3 Crosstalk in TNFR1 signaling 55312 8717 124056 8772 4616 331 7186 27035 PMC3825743__F5 Quantitative Phosphoproteomic Profiling of Human Non-Small Cell Lung Cancer Tumors 5286 2534 545 9846 6654 2033 22800 7157 2475 995 572 5925 5062 983 817 4209 9759 11016 2004 PMC3826456__F2 Diagram of PI3K/Akt and Ras/Raf pathway (see text for details) 6009 3667 1956 7249 7248 PMC3830939__F2 Tudor: a versatile family of histone methylation ‘readers’ 472 27343 11201 112869 367 1786 2146 29128 8726 23512 5252 26147 PMC3840450__F2 Mechanisms of NFKB activation in T-ALL leukemic cells 10892 8915 1540 3280 5970 4791 PMC3841024__F4 Representative ingenuity pathway analysis (IPA) of relationship between significant genes involved in the response to mechanical stretch and/or BIRB796 treatment in engineered cardiac tissues 51316 2309 8061 80310 634 2069 3488 5743 796 PMC3841787__F5 Proposed signaling pathway model for VEGF-A signaling in hypoxia-stressed BM-EPCs compiled from the proteomic and gene expression analysis is highlighted here 5281 7422 846 6010 207 440279 4843 PMC3843585__F2 The PI3K signaling pathway 6714 5728 5163 6009 572 4193 PMC3845018__F3 Graft-versus-host disease signaling pathway and miRNA interactions obtained using IPA 7189 7124 3627 920 940 3082 114034 PMC3845098__F1 N-glycoprotein biosynthesis in mammals 101448070 56052 79868 1798 10195 79053 84920 29929 54344 8818 8813 29880 PMC3845579__F1 Regulation of mammalian target of rapamycin (mTOR) by the LKB1/AMPK signaling pathway 5728 7249 7248 6009 2475 PMC3848550__F2 Schematic representation of the sialic acid metabolism pathway in eukaryotic cells 51083 6480 10825 4759 129807 4758 PMC3848582__F5 Schematic model demonstrating functional involvement of NPM1, RAD50 and XRCC5 in DSB-repair in the progression of ovarian cancer cells 4361 10111 4869 7520 472 595 983 PMC3849943__F2 Network of the interactions of the miRNAs and their target genes (experimental observed or highly predicted) 1282 5328 7128 10221 3606 5743 3559 5795 9170 3683 80328 201633 5155 6489 2353 5054 9021 1803 50848 3604 7099 1000 4609 1435 8741 8829 940 949 4860 23129 2335 958 290 9966 5292 7046 8795 4035 100528032 22914 6347 5800 1601 4323 7857 598 2512 PMC3854412__F7 SIRT1 negatively regulates amyloid-beta-induced inflammation via the NFKB pathway 23411 3569 6120 PMC3857018__F1 Potential mechanism for active DNA methylation involving TET-mediated oxidation of 5mC, followed by TDG initiated BER pathway via recognition of 5hmC and 5fC (AP is an abasic site) (adapted from ()) 200424 80312 54790 6996 PMC3858599__F1 NAD+ metabolism, a therapeutic target for age-related metabolic disease 130013 1690 23475 10135 203447 PMC3858858__F4 Overall PI3K and MAPK-Erk signaling is complex, but can highly influence the balance between cell survival and death 5728 2475 572 581 PMC3859141__F2 Molecular Pathways: Sterols and receptor signaling in cancer 1956 3949 19 50814 10682 1717 6608 22937 PMC3860334__F7 Different vesicle transport pathways and the functions of Rab GTPases identified from the hUCBMSC MVs 326624 51552 11031 376267 83871 7792 11021 10981 22931 PMC3861642__F9 Genes in the insulin signaling KEGG pathway that are directly or indirectly regulated by EBF1 1879 10211 2319 1398 23433 5562 5563 5564 5565 5571 51422 8651 9021 32 355 122809 3099 5213 5214 2203 8789 208 10000 5295 8503 23533 5290 5291 5293 2997 3667 3630 5163 5164 3643 8660 8471 5499 5255 5500 5501 5507 5256 5260 5261 5834 7249 7248 5573 5576 5566 6009 572 2475 1977 3845 2885 399694 6655 369 5894 3265 2002 PMC3864081__F1 DAMP signaling through different PRRs 4615 114609 10392 64127 3661 3665 3603 PMC3865984__F1 Autophagy Pathway 23192 64422 10533 9140 9474 83734 PMC3865984__F2 Molecular regulation of autophagy 2475 9821 9776 8408 60673 PMC3870411__F1 TNF Signals through TNFR1 and TNFR2 receptors (A) but abnormalities in this signaling pathway in autoimmunity (B) can favor a pathway of selective apoptosis due to a variety of protein signaling defects 7124 8717 8772 7186 PMC3874812__F8 Cav-1 phosphorylation-dependent LPS signaling pathway in mediating lung inflammation in endothelial cells 929 7099 3654 6714 857 4615 51135 7189 PMC3875894__F4 Antigen processing and presentation (APP) pathway (#hsa04612) 3458 6892 821 567 1508 920 768219 PMC3877020__F4 UVA and UVB Irradiation Differentially Regulate microRNA Expression in Human Primary Keratinocytes 1952 5937 4191 4318 4552 4322 6876 7169 2580 7298 388 5425 PMC3877165__F2 Schematic view of integration of TCR signal transduction with diverse components of the actin polymerization machinery 324 3932 7535 3702 7409 998 752 PMC3877975__F5 Coordinately up-regulated genes of chemokine signaling pathway in monocytes from the VIR group (VIR versus BDL) 126669 2885 1794 387 PMC3880999__F1 Molecular details of BAFF/BAFFR-mediated activation of NFKB2 signaling pathway 7187 7186 5971 55294 PMC3884689__F7 Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery 2950 22803 4087 4088 6256 1432 4713 4613 5976 7046 23405 5594 4841 4086 10236 103 3313 1869 388 1789 2146 861 81 467 23677 7157 6935 468 3306 1786 9146 672 5931 7335 79977 50628 3065 2099 5747 6732 6626 4967 6201 29102 79923 8737 57605 5894 317 PMC3885718__F6 Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK 3667 208 23411 PMC3887071__F2 Synthesis and Biological Properties of Fungal Glucosylceramide 735 730 729 PMC3894167__F1 Is Non-Homologous End-Joining Really an Inherently Error-Prone Process? 4361 142 7517 472 PMC3896945__F1 Pharmacological approaches to restore mitochondrial function 2475 10135 952 9611 5465 7019 4899 6256 PMC3899964__F1 Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination 6469 2619 4089 50937 55959 6608 26118 5566 3398 1956 819 26469 3423 8324 8321 374 9135 6424 147111 10023 23401 2069 7039 26994 7046 51741 9209 5516 7320 51701 3315 1601 55109 4920 23043 6241 7003 2146 7273 4237 6387 4313 23385 4855 1908 5469 84246 960 8061 7536 1191 5332 4067 5581 811 847 5880 387 63928 6010 998 79658 84033 7454 94134 84986 50650 9844 PMC3900498__F1 Yin and Yang of PI3K vs PTEN in the regulation of beta cell proliferation 8660 5728 5163 7249 7248 6009 2475 PMC3901108__F3 Summary diagram showing the role of ATG16L1 and NOD2 in the autophagy pathway and the defects observed when Crohn’s disease (CD) associated mutations are present 55054 64127 9474 10533 PMC3901112__F1 Autophagy is initiated by stimuli that activate the phosphatidylinositol 3-phosphate kinase, Vps34 9140 9474 83939 64422 23192 468 PMC3903161__F1 Steps of autophagy pathway activation 9474 9140 9776 8408 60673 2475 22863 64422 PMC3904369__F1a Charity begins at home: non-coding RNA contributes to DNA repair 672 472 29102 3066 PMC3904428__F1 Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target 5898 10928 5337 PMC3904723__F7 Putative functions of the differentially expressed proteins in metabolic processes of rice grain development at high temperatures 759 2695 2597 PMC3906243__F6 Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets 2271 1719 55349 PMC3906548__F1 AT2R-mediated molecular pathways involved in tissue injury 627 355 367 PMC3906588__F1 UPR response underling memory consolidation in Alzheimer's disease 7494 83939 351 468 PMC3912738__F1 IGF signaling involvement in EMT 126669 2885 3667 5728 2932 PMC3912804__F2a Hedgehog signaling pathway in cancers-Type I-Ligand-independent cancers 5727 6608 2735 100187761 PMC3912804__F2b Hedgehog signaling pathway in cancers -Type II- Autocrine Ligand-dependent cancers 5727 6608 2735 100187761 PMC3913057__F3 ErbBs/EGFR(s) signaling pathways 2885 3716 5894 6667 2002 2353 3725 4609 PMC3916724__F1 Molybdenum metabolism in higher plant cells 2242 7498 7523 PMC3925679__F2 Bile Acid Receptors in Non-alcoholic Fatty Liver Disease 255738 3949 5465 5166 7436 7038 26291 9965 27329 4023 PMC3925772__F7 Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module 3569 6714 2475 253260 6774 PMC3925795__F1 Simplified schematic of macroautophagy in mammals 664 2475 120892 PMC3927995__F2 NFAT proteins activate an anergy-inducing program of gene expression 940 83737 836 1606 3725 23411 3550 7091 3458 27040 7535 PMC3929326__F6 Regulation of Hippo-Yap1/Taz signaling by polarity complexes 4771 92359 4485 64398 10207 154796 9113 26524 23513 PMC3929886__F8 Model for JMJD2B silencing on tumour suppression through DNA damage 6774 472 545 PMC3932224__F3 Summary of regulatory networks centered by typical 2-Cys Prxs 137735 5241 64127 54205 10549 5478 581 695 2056 1017 351 183 7001 7295 5728 367 4609 4282 PMC3933272__F4 WNT signaling pathway 51701 3240 6476 324 8454 399 759 PMC3942282__F1 The molecular mechanisms and pathways of BBR in reducing oxidative stress and inflammation 6010 7351 1728 PMC3942726__F1 Simplified schematic diagram of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway and proposed cellular regulation of muscle protein synthesis in response to hypoxia, caloric restriction, insulin, muscle contraction, and leucine 7248 7249 6009 1938 6194 PMC3943571__F1 Ras signal transduction 2475 791122 1431 PMC3944254__F5 Proposed model of hypoxia-induced cellular processes presumably leading to antifolate resistance 790 2356 1719 PMC3944267__F8 Proposed mechanism for the differential response of tenocytes to oxidative stress under different extracellular glucose concentrations 2308 3091 6662 PMC3946676__F2 Changing appetites: The adaptive advantages of fuel choice 25902 10797 157739 6472 6470 26227 4522 PMC3947125__F3 Schematic model of the autophagy pathway demonstrates several relevant markers of autophagy which are potentially influenced by a high cholesterol diet as well as possible points of regulation try resveratrol (RV) 3920 9140 9474 2475 PMC3953890__F1 EGFR-axis pathway that contributes to cyst formation and progressive enlargement in ADPKD and ARPKD 1839 7039 2885 PMC3958665__F6 KEGG pathway for Huntington's disease (proteins identified in our study of the PBMC proteome are highlighted by red stars) 4478 5978 3092 6891 6908 581 6418 PMC3959773__F1 Mitochondrial respiratory chain 1376 23590 57107 27235 51805 51004 57017 2110 PMC3960188__F1 mTOR pathway in colorectal cancer: an update 5728 3667 7248 7249 6009 PMC3960348__F1 Schematic overview of the mTOR signaling pathway with the most important factors and their action 5728 5163 7249 7248 6009 8408 6774 6446 PMC3960348__F2 Schematic overview of the mTOR signaling pathway with the target position of drugs 5728 2475 5163 7249 7248 PMC3965205__F1 Hypothetical mechanisms of tolerance within the TLR4 pathway 7099 3458 929 54472 3654 6761 7189 4615 PMC3965409__F6 Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway 929 7099 5879 4615 7204 PMC3967838__F1 DNA2 Resolves Expanding Flap in Mitochondrial Base Excision Repair 246243 1763 2237 PMC3969740__F2 A) Pathogen recognition receptors RIG-I and TLR3 detect HCV ds RNA and activate via their adaptor molecules IPS-1 and TRIF 7098 10379 3661 3665 83939 6773 PMC3970295__F4 Wnt signaling as a pathway to increase bone formation 50964 10023 324 1499 4040 4041 PMC3970924__F2 Molecular pathology of FLS in RA 7124 355 5728 6714 2353 3725 PMC3971994__F1 HGF/Met receptor signaling pathway 3082 2549 2885 PMC3975365__F3 So-called PI3-K/Akt/mTOR survival pathway 5163 5728 7248 6009 7249 5879 2475 4193 581 572 735 4661 331 7518 PMC3977891__F2 Interplay between Wnt signaling and other anti-ageing pathways 324 2932 10645 2475 23411 PMC3980586__F1 Molecular Pathways: Emerging Roles of Mammalian Sirtuin SIRT7 in Cancer 51547 2005 4609 4830 6201 6208 6222 2475 4553 PMC3982149__F6 Antibody against CD44s Inhibits Pancreatic Tumor Initiation and Post-Radiation Recurrence in Mice 8360 79923 6774 6657 331 595 PMC3982925__F1 PGD2 pathway in alopecia 5226 4513 4512 PMC3983080__F1 Multiple Model-Informed Open-Loop Control of Uncertain Intracellular Signaling Dynamics 27040 5335 3932 3702 2885 7535 920 PMC3983570__F3 Tau Acts as a Mediator for Alzheimer's Disease-Related Synaptic Deficits 23621 2932 1020 2534 PMC3983582__F2 Nucleotide excision repair (NER): the proteins associated with human diseases are highlighted 7508 2067 5111 PMC3986091__F3 Pathophysiology of Lung Injury Induced by Common Bile Duct Ligation in Mice 171177 57817 284996 6279 26253 100187761 2921 7124 2159 6289 7941 250 3605 56603 344 241 3579 338339 341 4151 11006 10981 PMC3988951__F6 Insights into TREM2-related signaling using data-driven network constructions and information provided by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis 2857 1794 54209 7805 1536 10766 27040 6850 718 7408 382 PMC3989738__F6 Direct target genes of hypoxia-mediated hypoxia-inducible factor-1A (HIF-1A) signaling 6515 7422 6513 5034 3091 1906 5230 3939 3162 PMC3989838__F1 Insulin effects on endothelial cells 3480 367 2475 80312 PMC3989988__F1 De novo serine biosynthesis diverges from glycolysis 2539 26227 27165 5723 1327 57103 PMC3993959__F3 Bioinformatic analyses expose alterations in nucleic acid binding and regulatory proteins 10523 892 55696 84324 6288 PMC3994981__F2 PI3K and Cancer: Lessons, Challenges and Opportunities 2887 6009 2475 253260 8408 1977 5728 4609 PMC3995458__F1 Biosynthetic pathways of glycerophospholipids 253558 9926 79888 283871 4018 10162 54947 5091 PMC3995826__F2 Pathways for (A) Maturity Onset Diabetes of the Young (hsa04950), (B) type 2 diabetes (hsa04930), and (C) Notch signaling pathway (hsa04330); adapted from Kanehisa, et al 10683 3955 4242 3643 3630 23385 9253 2475 5590 4279 84441 389692 55534 885 171558 PMC3996587__F1 Extended model for the cyclin/Cdk network driving the mammalian cell cycle 6502 1017 999 983 991 7465 PMC4001025__F1 Vpr induces G2/M arrest through activation of the SLX4 complex 84464 146956 80198 5347 545 891 995 983 PMC4003416__F2 Targets of Twist proteins in the DNA damage response pathway 545 472 4193 581 4609 208 PMC400410__F3 Functional associations of genes selected as differentially expressed in patients with juvenile rheumatoid arthritis (JRA) and normal controls 351 836 3458 4485 80742 2794 2357 567 3630 7124 4599 6714 5350 867 208 4863 PMC4009148__F2 Signaling pathways induced by IL-17F 84818 7189 5894 PMC4012266__F2 The autophagy process and signaling pathway 2475 9140 83734 9474 10533 64422 PMC4013180__F3 Multiple pathways can stimulate Beta-cell replication in obesity, and there is overlap of many of the downstream activators 1956 3082 2932 814 3651 PMC4013402__F1 Glucose and glutamine metabolism in cancer cells 6523 6541 2744 5163 PMC4013670__F6 Schematic describing the proposed anti-inflammatory response resulting from resveratrol treatment and its effects on TLR4 following stimulation of chondrocytes with IL-1B 3553 7099 4615 7189 PMC4013678__F2 Bayesian Brain Immune and Microglia Module 64005 5777 2357 920 6282 5880 341 112616 29108 834 7305 945 5265 10095 51296 2896 7462 1794 2876 6850 4067 54502 11027 140 7046 1475 861 5966 64098 54918 6518 3108 972 3122 3126 5742 3109 10863 3111 10312 257106 5788 1520 4242 10257 3597 706 7133 3588 57705 1230 10673 PMC4017408__F1 Wnt signaling pathway 999 1499 324 2932 PMC4018747__F4 Pathways leading from ssDNA-bound RPA to the recruitment of an error-prone polymerase η, ι, K or Rev1 for bypass of a potential template lesion 84126 545 353497 11201 51426 51455 6118 56852 5111 PMC4019504__F5 Integrated Analysis of Genome-wide Copy Number Alterations and Gene Expression in MSS, CIMP-negative Colon Cancer 11197 6714 1499 10454 4193 51701 351 960 6925 6422 22943 PMC4022190__F7 Biosynthetic pathway leading to the hypermodified tRNA base wybutosine (yW) 4553 55253 127253 PMC4023177__F3 Key signaling pathways involved in the early recurrence/metastasis (R/M≤6months) and late recurrence/metastasis (R/M6-12months) of H-HCC 9343 811 3297 8087 218 6741 4353 116 1052 837 2752 581 5925 100652748 126014 4976 3827 6610 2618 10452 5578 351 2720 1053 4047 5657 1075 6643 257364 6927 284 5970 1785 335 6774 6714 80830 5156 2150 4582 2243 10401 2244 4128 1803 3960 2266 644 3182 25803 3916 6721 23191 3843 3856 3949 3956 56616 5493 4153 51738 8743 9373 1191 2194 3458 25959 43 1401 6646 26471 30835 11151 3596 3684 10062 100128266 336 10631 345 2822 PMC4027049__F2 TGFB signalling in context 29102 51592 4089 7048 659 7189 4092 100187907 387 6010 PMC4030405__F1 Complement system 1356 716 715 717 718 727 729 735 730 PMC4037911__F1 Bid can be activated by multiple proteases in response to a variety of pathophysiological signals 8772 331 637 23788 581 PMC4040611__F5 An MAPK network downstream of SDF-1/CXCR4 signaling in breast CSCs 7852 6654 5163 9448 4296 5783 5784 5782 5605 5499 10298 6195 8550 4140 PMC4041145__F1 Akt and NFKB signaling in drug resistance mechanism of tumor cells 331 4193 4513 572 PMC4041276__F8 Signaling pathways mediating DON-induced RSR, including the MAPK (A, blue), NFKB (B, red), AKT and AMPK pathways (C, green) 6714 3925 10514 22984 7249 7248 2475 1786 79753 3606 3569 7097 2932 PMC4042557__F4 Graphical overview of the Canonical Pathway analysis 627 6863 6714 2002 PMC4045488__F1 MicroRNAs in pancreatic cancer metabolism 406938 406948 6510 2195 948 PMC4046179__F5 98 proteins that showed significant changes in oxidation levels with HFHS diet were subjected to IPA 6476 1537 6389 6391 1340 7388 6390 PMC4049898__F2 Wnt and planar cell polarity signaling in cystic renal disease 79633 1499 387 5879 5754 2932 324 PMC4051134__F3 Targeting JAK2 in the therapy of myeloproliferative neoplasms 3717 2056 2057 PMC4051800__F6 Causal BN learned from breast cancer cases for the ErbB pathway 5336 27 25 1839 5335 1398 374 369 1027 868 23624 5602 867 4893 572 5894 5295 8503 5605 5296 1950 6655 3845 6714 2064 817 6654 5747 2002 818 2885 5595 4690 2065 2066 5601 3725 5582 5578 2069 8440 1399 5594 673 1956 10000 4609 9542 5294 208 25759 5609 5290 2549 5063 3084 5058 53358 7039 207 5062 1978 685 3265 145957 10718 PMC4058013__F3 KLK5 protease suppresses breast cancer by repressing the mevalonate pathway 3156 6010 8622 1717 80270 3949 255738 26119 51141 PMC4061164__F1 Cisplatin-induced inflammation is mediated through multiple effectors including activation of NFkB, TNFA, and PARP 3383 7412 3082 999 6774 PMC4063317__F5 Receptors and cellular signaling pathways implicated in the antitumor effect of ANP 10699 6774 2932 1499 PMC4065826__F2 MAP kinase signaling in SC plasticity 3976 2668 3725 85451 3084 6347 PMC4068075__F3 Consequences of EMT on innate signaling 7187 7185 5970 1025 10318 3569 PMC4071053__F2 Molecular network generated by Ingenuity Pathway Analysis (IPA) of highly significant gene changes in human RPE cells after in vitro stimulation with AGE (10 μg/mL) 9068 6373 6352 87178 3458 5610 3434 91543 3437 11274 151636 6772 3433 83666 64135 4600 3431 54739 PMC4072629__F3 VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome 11180 202051 64098 5609 57551 817 23336 8317 9223 8204 1272 4828 4783 1284 5068 6502 10287 4144 10451 56624 3248 6579 5332 4923 1910 10397 26052 11255 2355 3737 3746 1595 6843 3736 112755 PMC4072696__F9 Integrative Identification of Deregulated MiRNA/TF-Mediated Gene Regulatory Loops and Networks in Prostate Cancer 1017 5728 5163 4193 2885 2475 PMC4073476__F3 Bile Acids are Nutrient Signaling Hormones 5465 5163 5091 3667 PMC4075272__F2 Signaling pathways altered by MVNP and mutant p62 6883 23411 7189 7421 PMC4077819__F5 Inhibition of C3 Convertase Activity by Hepatitis C Virus as an Additional Lesion in the Regulation of Complement Components 718 721 1356 717 727 PMC4077945__F1 Lipid metabolites as metabolic messengers in inter-organ communication 5465 355 79071 PMC4078240__F4 Map of SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis 3638 51141 22937 2932 57678 47 31 32 3157 2194 83401 6319 4047 3158 84532 2224 PMC4080280__F4 Stage-specific expression of individual genes in Ras and Wnt pathway orchestrate cardiogenesis 3976 5266 10875 1950 659 4040 657 10097 5159 4086 5728 2549 4193 5781 2885 50964 5293 8517 6774 408 3266 2932 324 3725 5606 5607 5608 5596 5597 2353 5598 6300 1499 6657 7008 79923 PMC4082184__F2 Turning Off AKT: PHLPP as a Drug Target 3667 5728 4485 PMC4083591__F1 Type I Interferon in the Pathogenesis of Lupus 3665 11277 25939 717 3654 7128 9474 7297 6775 5132 115004 PMC4084561__F3 Regulation of type I interferon responses 7124 3716 7297 6850 11274 6773 6772 27161 406947 406938 PMC4084718__F4 Contextualizing Sharpin within the NFKB pathway by comparative analysis of mutant transcriptomes 7097 4615 7189 81858 10616 3552 4792 3603 3606 7124 PMC4085325__F4 SphK1/S1P/S1PR1 feed-forward loop sustain signals promoting colon tumorigenesis.Notes: SphK1 produces S1P, which is kept in the cell and/or is exported in the extracellular milieu 124976 1901 8877 6774 PMC4085879__F2 Targets in T-ALL: PI3K/AKT/mTOR, cyclin D3:CDK4/6, BRD4/MYC 23476 1021 1019 5163 5728 2475 PMC4086339__F5 Deregulated focal adhesion pathway in NSCLC cell lines 857 1399 2316 387 81 2317 5594 7414 7408 824 103910 60 PMC4090290__F1 Epidermal growth factor receptor (EGFR) pathway activation during HNSCC carcinogenic process 4513 1956 7039 1950 3717 6774 2475 PMC4091817__F2 The oxidative stress regulatory pathway in erythrocytes 2539 2936 6647 2876 7295 7296 847 7001 PMC4095859__F3 Metabolic requirements for the maintenance of self-renewing stem cells 2475 5371 2194 3418 PMC4095859__F4 Metabolic requirements for the maintenance of self-renewing stem cells 472 2475 6997 PMC4095906__F3 TLR and BCR signaling and integration in CSR and antibody responses 7099 613 958 4615 51135 5336 7187 7186 7189 8915 10892 2475 54106 23118 257397 5971 3221 57379 4118 PMC4097957__F1 TLR4 signaling pathway 7099 51135 3656 7098 7189 7187 23118 257397 29110 8195 3661 4118 4615 PMC4098619__F1 Schematic diagram representation of some of the pathways regulated by HNF1a 3651 6514 1387 84105 1499 5092 PMC4100143__F1 Diagram of CD4 T cell differentiation and immunomodulation by the AhR signaling pathway 7124 6772 3558 325 50943 3586 3565 3569 3596 920 2625 59067 196 PMC4102378__F2 WNT signaling pathway 999 3611 6714 1499 2932 595 4609 PMC4103658__F7 GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst 2627 79923 2249 PMC4105535__F4 Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients 652 51176 4609 5925 22943 672 7157 367 3725 6667 PMC4111858__F5 Two-step model for OR-instructed axonal projection of OSNs 5361 8829 84623 84063 PMC4112623__F1 The core Hippo signaling pathway in Drosophila and humans 9113 26524 4485 55233 92597 60485 4771 7003 8463 7004 7005 PMC4112623__F2 Cancer related pathways and processes that input into the Hippo pathway 4771 4485 2475 60485 9113 6469 PMC4114106__F2 Ubiquitination of RIP1 is an early pro-survival checkpoint in TNF signaling 8717 836 8772 23118 257397 PMC4115628__F2 Sphingolipid metabolism 1431 5091 6611 1674 PMC4116751__F1 Model Genetic Pathways 1950 1956 171013 2885 8844 9439 PMC4116803__F1 Improving GD T cell functions by TLRs in combinatorial therapy 3652 969 942 100507436 PMC4118469__F1 Molecular Mechanisms of Neurodegeneration in PD 4129 120892 27429 10131 65018 2597 2203 22933 PMC4122595__F2 AB oligomers activate several ‘stress-response’ kinase pathways in neurons 10645 7249 7248 2475 9776 3375 PMC4125008__F1 current targets of nuclear DNA repair pathway proteins and their functions 4255 4436 7507 142 5423 5888 2237 PMC4127377__F9 MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 4094 64798 6662 PMC4128340__F3 Canonical non-Smad pathway tumor growth factor (TGF)B signaling 2885 4089 4088 2012 3269 2014 5266 3678 9103 6876 9961 3976 5329 30846 1200 3383 5328 8829 5002 1050 10398 3371 1948 5322 1284 8828 1889 9235 10630 861 87 6448 602 53918 26031 9454 5371 4323 6774 7056 8572 771 977 3679 3675 9180 55240 2316 7791 10581 PMC4132373__F1 A healthy neuromuscular junction (NMJ) is a tripartite synapse composed of a motor neuron (MN) terminal synapsing onto a muscle fiber 960 8829 351 10371 2043 PMC4134348__F1 Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization 114609 51135 7099 7124 3661 7054 PMC4139831__F1 Wnt/Beta-catenin signaling pathway 4040 4041 324 8658 1499 PMC4140012__F7 (Summary illustration): Three USPs regulate Imd activation or stability and downstream signalling 57602 9099 9736 5966 PMC4143405__F5 Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer 1879 6418 604 2308 5979 5079 3662 7494 4851 6469 3280 2736 595 10873 5075 894 PMC4143607__F5 The role of the PHDs in the cell cycle 55125 6502 545 PMC4145816__F1 Ras/MAPK signaling cascade and small molecule inhibition 6654 2885 673 PMC4150259__F1 An overview of oncogenic KRAS-driven RAF/MEK/ERK and PI3K/PDK1/AKT signalling networks in pancreatic cancer 1950 1956 5728 3845 5163 2475 PMC4150610__F2 Interferon-inducible effector mechanisms in cell-autonomous immunity 2634 2633 388646 23192 718 29110 9474 23557 538 120892 4843 PMC4152244__F1 Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma 5163 7249 7248 6794 3091 2475 664 7422 PMC4152724__F1 Immunoregulatory molecules are master regulators of inflammation during the immune response 324 3458 920 941 942 940 PMC4154952__F5 Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model 170482 28959 50856 2444 10777 5175 7161 54583 8446 1915 56342 7629 65003 PMC4155023__F3 Growth factor- and cytokine-regulated pathways are activated during liver regeneration 5340 595 85451 718 6774 9021 PMC4160340__F2 Rho-GTPases as key regulators of T lymphocyte biology 324 920 3932 5880 5879 7535 399 7409 8915 10892 998 6010 2885 27040 5335 PMC4161521__F6 NFAT5/REDD1/mTOR/Notch pathway model 10725 7249 7248 PMC4161976__F7 MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer 207 4193 51548 PMC4166351__F1 AB production and removal from the brain 3416 351 7276 PMC4166520__F1 ATX-LPA Receptor Axis in Inflammation and Cancer 4018 6476 387 157313 PMC4167320__F1 Overview of the extrinsic, intrinsic, and phagocytosis-induced apoptotic pathways 5111 836 842 637 331 PMC4170638__F6 Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/Beta-catenin signalling in pancreatic adenocarcinoma 1499 2932 324 6774 595 4040 4041 PMC4170887__F2 Gene interaction networks specific to the varying doses of 60Co radiation exposure 8772 8743 5423 1399 5111 2120 196 4791 1636 8932 PMC4171984__F1 Insulin/IGF-1 signaling pathways 3481 3479 3667 8660 2885 7249 5728 7248 5163 253260 2475 2887 572 3630 PMC4172058__F1 Schematic diagram depicting the most representative signaling of the PI3K/AKT pathway 5163 5728 2475 253260 7248 7249 2932 595 572 PMC4175497__F1 Molecular signaling altered in Fragile X syndrome 43 4131 2932 23237 351 4318 PMC4180975__F8 Model depicting CtsZ regulation of the protumorigenic functions of TAMs and cancer cells 1522 6714 8205 PMC4181723__F7 Proposed TLR signaling mechanism by CS14K: a hypothetical model of TLR4 signaling, pathway activated by fusion protein, in a MyD88-independent fashion 4615 7189 3661 6772 7124 PMC4182081__F2 Regulation of YWHAG, YWHAB, and PCNA by hsa-miR-185-5p in a cell cycle pathway 4087 7851 993 4998 PMC4182081__F4 Regulation of TCF7 by hsa-miR-20b-5p and hsa-miR-17-5p in a thyroid cancer pathway 673 5979 7175 1499 4609 PMC4183126__F2 PALB2 links BRCA1 and BRCA2 into a pathway of products of breast cancer susceptibility genes 672 79728 675 5888 PMC4185231__F6 TLR2-dependent activation of Beta-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation 7097 10333 2932 8854 50943 PMC4190558__F1 Repair of oxidative DNA lesions by the MMR pathway 4595 9156 3978 5395 4436 2956 4292 27030 56852 5111 PMC4190587__F3 MicroRNA Regulation of Smooth Muscle Phenotype 6714 688 93649 9314 387 6010 5292 894 2002 PMC4192461__F11 Proposed schematic for the maturation of mNT and its role in exporting mitochondrial Fe-S and reactivating the cytosolic apo-IRP1 into Fe-S aconitase after H2O2-induced oxidative and nitrosative stress 4682 57019 23479 9054 2395 4335 PMC4196276__F5 Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets 1950 25759 2885 126669 3479 PMC4196962__F6 Interleukin-1B Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes 6469 6608 5727 2735 3553 2920 6347 6364 PMC4197103__F1 Necroptotic signaling in adaptive and innate immunity 7124 7099 8772 8717 8737 7098 7186 11035 1540 197259 PMC4199664__F1 Cell cycle regulatory pathways 4763 3091 2475 1021 1019 983 9997 57103 1956 PMC4199871__F2 WNT Signaling in Bone Development and Homeostasis 4040 4041 22943 50964 324 1499 11197 PMC4204167__F2 The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor E2-related factor 2 (Nrf2)-antioxidant response elements (ARE) signaling pathway 8452 9817 4094 PMC4204437__F1 Fanconi anemia (FA) proteins implicated in interstrand cross-link (ICL) repair 672 84464 5889 PMC4206998__F2 MicroRNA induced by FSH at spermiogenesis 2492 3480 5728 7422 595 894 3479 PMC4207397__F1 Dicarbonyl stress and RAGE signaling 2739 3383 7412 PMC4212479__F1 Sphingolipid metabolism 29956 204219 79603 91012 1674 340451 64781 875 6611 PMC4213571__F2 Model depicting Tax-induced shuttling, localization and activation of canonical and noncanonical NFKB signaling pathways 1540 8887 10133 4170 7189 10868 55540 6047 5971 64236 PMC4214394__F1 Activation of mammalian target of rapamycin occurs through a complex signaling cascade 627 6009 7249 7248 2475 253260 29904 1938 PMC4214731__F8 Network-Based Classification Model for Deriving Novel Drug-Disease Associations and Assessing Their Molecular Actions 2308 6774 2885 92170 2 5781 185 6654 5335 207 5468 3558 1385 4846 PMC4214862__F1 PI3K/AKT/mT0R signaling pathway 253260 5163 2475 5728 572 4193 7249 7248 595 1977 1999 PMC4216012__F1 Wnt/Beta-Catenin Signaling Modulates Human Airway Sensitization Induced by B2-Adrenoceptor Stimulation 4040 4041 4920 6259 23002 324 10023 2932 1499 6010 PMC4216797__F3 Mechanism and Role of AMPK activation 10645 7248 7249 8408 2309 6009 PMC4218690__F1 Honokiol and ionizing radiation (IR) affect Notch signaling 983 4609 581 4193 PMC4222248__F7 EGF signaling pathway to stimulate proliferation of conjunctival goblet cells 1950 6714 2002 PMC4222901__F2 Cytoskeletal modulation and signaling 445347 79026 10006 2059 4690 7410 5879 382 998 1956 PMC4222988__F1 Signaling through PI3K/mTOR and Ras/Raf/MEK/ERK pathways is controlled by negative feedback loops 1950 2549 2885 1956 3630 3667 8660 5058 2887 5728 5163 7249 7248 6009 3643 PMC4222988__F2 A) Compensatory over-activation of signal transduction pathways induced by rapamycin-mediated suppression of negative feedback loops 1950 2549 2885 3630 3667 8660 5058 2887 5728 5163 7249 7248 6009 3643 PMC4222988__F3 A) Compensatory over-activation of signal transduction pathways induced by dual PI3K/mTOR inhibitors 1950 3630 2885 3667 8660 5058 2887 5728 5163 7249 7248 6009 3643 2549 PMC4224073__F1 Complement system: an overview 1401 5340 716 715 717 718 720 721 727 730 729 735 PMC4226790__F1 Development of mononuclear phagocytes 947 1524 9935 PMC4227184__F10 Pathway analysis 1956 3265 847 5170 7409 5879 5058 1431 3725 7412 4312 7422 PMC4228291__F1 Wnt signaling pathway and its key components 4040 4041 324 1499 PMC4232466__F2 Inflammophilic character of the periodontitis-associated microbiota 727 729 7097 7096 57154 4615 4118 387 PMC4234172__F2 Signaling pathways employed by CSCs: Distinct combinations of paracrine and juxtracrine signals induce the EMT in different contexts 1499 7855 4919 6608 4041 3717 6774 4087 4088 4089 2353 6935 PMC4237178__F4 Canonical and non-canonical Wnt pathways exert opposite effects on the formation of the vertebrate NMJ 6010 1499 1855 4038 4593 PMC4238427__F4 Ingenuity pathway analysis of top differentially affected pathways from the microarray data 2764 23321 26130 10365 PMC4240309__F2 Smad-dependent and Smad-independent TGFB family signaling 238 7189 387 998 2475 PMC4247524__F1 Short-patch BER pathway 5423 11284 7515 3980 PMC4248790__F4 Piwi proteins and piRNAs step onto the systems biology stage 29947 1788 1789 54456 79084 10419 8468 56165 122402 PMC4252768__F1 Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders 7474 1499 6010 324 4040 4041 4920 PMC4253421__F7 LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/Beta-catenin signaling pathway 8549 324 2932 1499 595 4040 4041 PMC4256275__F11 RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities 220 2248 6899 PMC4263263__F2 Metacore analysis of leading edge genes 5347 324 991 6502 PMC4263263__F3 Metacore analysis of leading edge genes 9451 22926 7494 7186 759 847 468 1432 3725 581 3266 PMC4263464__F1 Top overlapped pathways for non-users (top) and users (bottom) of oral contraceptives.Notes: Hexagon shaped are genes 10093 2100 2099 1729 4638 1387 1017 4660 10095 6093 27043 1020 2810 5185 64750 7706 9133 23609 10097 5594 1021 1019 1018 395 3569 1072 2934 10458 2065 7157 2064 78992 387 9138 3397 598 23426 2885 8651 3667 5478 9021 3572 3725 1399 1956 2002 11122 4609 4103 6850 596 5609 3717 1457 1051 5777 5608 8837 5580 5578 4790 5583 1616 6416 1024 5894 3551 PMC4266467__F1 iNOS: A Potential Therapeutic Target for Malignant Glioma 1950 1956 6774 4513 PMC4266469__F1 Schematic demonstrating the effects of AMPK signaling in stroke 4280 2147 572 PMC4267164__F2 NOD1 and NOD2 signaling 1611 10392 64127 23118 257397 3550 5971 PMC4269194__F1 Spatiotemporal regulation of feeding response by O-GlcNAcylation 3667 5163 8473 2932 PMC4269881__F6 EHEC-host interactome reveals novel targets for the translocated intimin receptor 408 10458 51440 7337 3241 83988 387 2099 998 113878 4860 10363 7316 8517 6569 151194 203068 7277 929 7099 4615 3654 51135 8717 7186 7188 7189 10454 2597 10616 5434 PMC4269892__F6 Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer 83742 23049 5976 PMC4270428__F1 Multitask Learning of Signaling and Regulatory Networks with Application to Studying Human Response to Flu 150684 1399 8553 4609 10155 7706 23321 7431 1410 60 5111 10657 1398 5430 472 7329 4869 1642 6477 9961 4691 3303 3320 203068 4193 10273 1387 5970 2099 110740339 1050 2113 2355 6662 6667 6670 6671 5451 PMC4275944__F5 A schematic linking the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation to status epilepticus (SE) pathogenesis 7099 114548 3553 PMC4276909__F1 miRs regulate vascular medial calcification 100313837 407021 860 238 PMC4276927__F4 Three intracellular signaling pathways are shown schematically 2776 5290 5163 4763 4133 5604 7248 5595 7249 6009 2475 PMC4277277__F2 Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats 91734 3157 3156 4598 10654 4597 4047 6713 2224 10682 1717 PMC4281037__F4a IL-23-IL-17 immune axis: Discovery, Mechanistic Understanding, and Clinical Testing 84818 29110 7186 7188 7189 7187 9618 29761 2932 257397 23118 PMC4281383__F4 Differential expression in LCI 103 64135 3430 3434 3437 10379 4599 5696 727 713 83666 3553 3665 6139 6233 6189 3921 9636 10010 81030 54625 8743 56829 8651 51284 4047 3458 7297 6772 6773 8554 581 4938 10581 8519 3659 6890 10410 PMC4288257__F5 Malonylated proteins in glucose and fatty acid metabolism pathways 2632 7360 5836 5236 5226 2203 7086 229 2819 2597 5230 5232 5223 5224 2168 80221 51703 2180 65057 355 1962 10449 30 3939 5091 38 39 47 4190 3158 3155 2271 3417 PMC4292169__F1 The meiotic recombination pathway 23626 4361 9156 PMC4292735__F1 Insulin growth factor 1 (IGF-1) signaling pathway 3479 3480 3667 8660 2885 5163 64798 253260 2475 7249 7248 572 2932 PMC4295834__F4 Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials 7422 7852 1630 PMC4295872__F8 Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation 1956 2064 8772 9564 841 29893 8412 94240 836 840 331 572 842 PMC4297928__F1 Simplified pathophysiology of reactive oxygen species (ROS) and etheno-DNA adduct formation 4353 4015 4513 PMC4303658__F1 Thymidine metabolism in the cytosol and mitochondrial matrix 7084 7298 978 1719 1633 PMC4307189__F2 Network view of (A) 104, (B) 188, and (C) 299 putative drug-resistant cross-talks between pathways using Reactome, KEGG, and WikiPathway pathway databases in Breast Cancer Cell-line: SKBR3 (GSE38376) 2066 6010 4609 208 3815 3845 2778 1956 4803 6608 PMC4307283__F4 Lipids regulate apoptotic signaling in the cells 842 837 838 836 23581 839 843 834 841 PMC4309185__F1 Toll pathway in the fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse 7099 929 4118 4615 3654 51135 7189 10454 23118 PMC4309263__F6 Schematic representation of the reciprocal auto-sustaining loop between Jagged1 ligand and Notch3 receptor in T-ALL 4851 4854 182 102 6868 PMC4312599__F5 Coordinately up-regulated genes of WNT signaling pathway in HCV versus HIV 51701 9350 1499 4089 4088 324 25805 50964 6477 6500 8454 9978 9475 387 PMC4313349__F1 Nutrient Sensing Mechanisms and Pathways 22937 948 7415 3156 PMC4320069__F1 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants 3817 354 2263 3759 4133 5604 79083 6662 6910 6498 389136 9314 4824 677 6671 153572 688 PMC4320069__F3 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants 4477 4316 354 2255 5010 79083 638 4824 7015 4194 6498 6928 PMC4320069__F4 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants 56937 4477 7015 5010 354 2255 367 3655 4824 4804 8725 PMC4320499__F6 MM patient 3 profile schematic 8454 836 1026 5366 4851 9531 602 5871 9986 4296 1499 3845 4214 7786 857 7249 7248 999 6009 1432 9049 5599 595 5465 6667 3516 3091 596 4170 598 1017 1019 PMC4320664__F3 Drug targets downstream of receptor tyrosine kinases involved in synovial sarcoma (RTK) 3480 5163 3667 5728 26259 253260 572 2475 596 2887 581 2932 2309 7249 7248 7088 6760 1386 11221 2002 1958 4170 PMC4323371__F1 TERRA regulation of telomere length for the protection of chromosome ends involving TRF2 10664 9156 472 PMC4324503__F5 Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation 1080 7099 857 PMC4324544__F8 Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model 355 572 8772 PMC4325211__F3 Placental oxidative stress triggers the expression of transcription factors to regulate angiogenesis and trophoblast invasion 11279 6667 6670 6774 PMC4325920__F1 Roles of FMRP in the pathogenesis of AD 8831 4763 23237 5728 2534 7248 7249 5058 2932 6009 2475 1977 4131 4133 351 PMC4331476__F4 Representative illustration of key gene distribution (hsa04720 and LAP_hsa04720s) 406974 5493 7939 PMC4333878__F1 Apoptotic cell death pathways and (b) inhibition of the apoptosis signalling pathway 355 637 581 2308 6774 6772 PMC4333878__F2 EBV interaction with the Bcl family 958 972 637 PMC4335356__F4 Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases 4803 11151 283899 5531 3835 8452 2275 7157 8448 5111 226 7316 26470 83719 10423 4150 9961 1457 3725 8479 79447 9344 23475 351 112476 PMC4335664__F3 The crosstalk between the IGF-1 system and estrogens in breast cancer 3479 3480 3667 2475 PMC4336165__F2 Growing recognition of the role for rare missense substitutions in breast cancer susceptibility 10111 4361 472 7157 11200 580 672 83990 79728 675 5888 PMC4336604__F9 How p-CREB acts as a common downstream effector for multiple signaling pathways that regulate BCRP mRNA expression Xie, et.al 1950 1956 200186 PMC4338284__F4 Molecular Characterization of the Peripheral Airway Field of Cancerization in Lung Adenocarcinoma 1605 390 9049 64834 2683 10979 10226 9097 4133 5604 1730 1846 3475 23462 11334 PMC4340657__F1 Modes of cell death 114548 8772 197259 PMC4343072__F6 Consequences of mutant BRAF V600E in LCH 673 4615 1848 369 PMC4344549__F1 Canonical Wnt signaling 22943 4040 324 1499 PMC4344863__F1 Input overload: contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis 5950 9227 157506 9249 8854 1382 64220 PMC4345914__F2 TLR signaling pathway and modulation effector molecules 10333 7100 7097 7096 7098 4615 51284 54106 51135 4118 3656 7189 23118 257397 7187 29110 3661 3665 PMC4349862__F6 Overexpression of the Transcription Factor Sp1 Activates the OAS-RNAse L-RIG-I Pathway 6041 57506 3661 PMC4350902__F3 Schematic depiction of PTEN functions in nucleus and cytosol with regard to its posttranslational modifications 4193 5728 80762 7874 8975 5888 324 PMC4352384__F5 Polymicrobial synergy and dysbiosis in inflammatory disease 7097 7096 57154 4615 4118 387 PMC4352384__F6 Polymicrobial synergy and dysbiosis in inflammatory disease 727 7097 7096 7852 7099 114548 3553 2932 PMC4354340__F8 miR-4689 regulates EGFR signaling pathway 1956 3845 207 PMC4364457__F3 MicroRNAs Are Part of the Regulatory Network that Controls EGF Induced Apoptosis, Including Elements of the JAK/STAT Pathway, in A431 Cells 693181 6950 7430 1072 8815 60 10376 11034 5478 2547 10487 908 PMC4367126__F1 Induced regulatory T cells in inhibitory microenvironments created by cancer 84890 920 50943 4513 7939 8829 5132 3902 64218 PMC4375817__F3 The modulation of downstream signaling pathways of the brain derived neurotrophic factors (BDNF) by glucocorticoids (GCs) 627 2885 2638 PMC4376601__F1 Sphingosine-1-phosphate receptor 2: a novel bile acid receptor and regulator of hepatic lipid metabolism? 9294 7808 9965 3667 2264 1581 4547 7436 5360 5465 3603 PMC4377108__F2 Regulation of Molecular Pathways in Ischemia Reperfusion Injury after Liver Transplantation 28996 2177 472 545 2002 4609 4149 4193 3091 79629 4089 5933 51176 6929 6925 PMC4377868__F1 Biological roles of sulphate and pathways of sulphate homeostasis 875 1491 1036 2805 6821 9060 50964 PMC4378640__F4 Schematic presentation of chloroplast proteins affected in executer mutants and WT plants after light treatment compared to WT plants under normal or growth light conditions, as shown in Table 3 50975 6120 5091 7175 PMC4382287__F2 Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection 5601 6300 5603 5599 5600 1432 5743 5594 4843 3551 5970 7124 PMC4382460__F2 IL-10 signaling pathways in normal and abnormal conditions 7297 3716 6774 941 PMC4382841__F4 Proposed model of novel role of AQP1 in tumor biology 1956 358 387 PMC4382841__F5 Proposed model of novel roles of AQP3 and AQP5 in tumor biology 360 1956 6714 2475 595 PMC4383156__F5 The major pathways involved in the molecular mechanisms of cancer 2885 1398 998 759 4351 246751 637 8772 PMC4383314__F3 Serum starvation induces changes to cellular metabolism and chromatin remodeling proteins 3157 4597 2224 4706 51 9415 230 51011 2639 594 5250 7388 51144 48 1717 3159 3148 4869 8208 1105 55723 10664 1063 57332 8242 57680 10951 6045 9682 4221 10919 5929 8841 84148 9219 4678 PMC4384662__F4a PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting 5879 998 1956 613 930 940 958 5728 PMC4387238__F2 Signals for the lysosome: a control center for cellular clearance and energy metabolism 7942 2242 64223 64798 6009 5465 PMC4387772__F1 T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation 940 5728 5163 11113 7249 7248 23411 2308 2309 4609 3091 50943 1493 PMC4387772__F2 T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation 2597 383 948 942 941 1493 29851 PMC4390903__F2 DNA damage pathways and how CHK1-, WEE1-, or CDK1 inhibitors can synergize with cytarabine to increase its DNA damaging efficacy in AML 6741 472 5884 3364 5810 10111 4361 545 4193 995 993 7465 4661 1017 983 PMC4391727__F5 Differentially expressed genes related to BMP signalling at day 0 to 3 of arthritis in comparison to non-induced controls 651 860 8646 10468 652 655 2013 659 4089 4087 PMC4392845__F1 13C Isotope-Assisted Methods for Quantifying Glutamine Metabolism in Cancer Cells 1431 3417 3418 2744 2271 4967 PMC4394435__F1 The ubiquitination pathway 7317 55236 7320 7322 4734 7189 6502 6049 PMC4394435__F2 The SUMOylation pathway 1431 10055 5903 PMC4394589__F5 Regulation of genes in the JAK/STAT signaling pathway 122809 8651 9655 8835 9021 30837 857 8554 3716 3717 10401 3569 3572 3718 6772 7297 6773 6774 6775 6776 3454 3440 3442 3446 3445 3447 3443 3441 3448 3444 6778 3455 3459 3460 5770 5777 PMC4394599__F2 Molecular pathway of glycolysis in NSPCs 3099 9997 5728 5226 57103 2475 4609 5166 2023 PMC4395138__F1 Extrinsic and intrinsic pathways of apoptosis 7124 355 8772 637 351 PMC4397972__F4 Gene network analysis for 18 key genes involved in age-dependent tumor progression 8772 836 1499 6275 7040 7157 2132 6427 5094 10963 6624 891 6382 397 581 3073 8661 811 2683 5430 2923 PMC4398700__F3 Ingenuity® Pathways Analysis reveals a possible network of genes activated in IEC-6 cells upon induction of the ephrin-B pathway 467 2200 3726 2152 2353 5743 3280 6667 196 831 5292 1843 PMC4399989__F8 Programming of Obesity and Comorbidities in the Progeny: Lessons from a Model of Diet-Induced Obese Parents 7038 5465 355 PMC4402072__F5 Schematic model of AREG in the Warburg effect and tumorigenesis 374 1956 6945 PMC4403188__F6 GAi1/3-mediated activation of TLR4 in response to LPS 7099 929 2549 3929 2821 4615 5970 3553 7187 3661 3569 PMC4403295__F1 The UPR signaling pathway 7494 22926 468 1998 PMC4403295__F2 ER-mitochondrion tethering 55669 9927 7416 51024 9217 5371 114548 5728 PMC4403761__F1 S-nitrosylation in NFKB signaling 1950 7099 4615 8717 7186 7189 23118 PMC4405010__F1 Sessile serrated and traditional serrated pathways 673 3845 3490 4292 4255 PMC4405775__F1 Dependence on signaling pathways based upon tumor suppressor status 5266 387 23678 6774 6714 PMC4409526__F3 Diagram depicting altered mRNA expression of molecules involved in the regulation of the actin cytoskeleton by NMDA signaling pathways in schizophrenia 88 5501 56288 9459 4983 5578 8997 84687 4082 55607 998 6093 3984 11034 1072 1627 PMC4410310__F3 Gallus Gallus retinol metabolic pathway from KEGG 10901 8228 9227 7364 6121 PMC4412130__F1 Eukaryotic mechanisms that manage replication– transcription conflicts 545 7150 11219 4360 80119 9400 PMC4414745__F4 Regulation of rice Hd3a and RFT1 expression by photoperiod 30845 10938 91869 PMC4418918__F6 Translational effects of Stat1 6772 5294 5163 1977 27250 331 PMC4422111__F4 Kreb's cycle used to determine relative flux rates through acetyl-CoA synthetase (ACS), pyruvate dehydrogenase complex (PDH), pyruvate carboxylase (PC), and glutamate dehydrogenase (GDH) 5091 1431 4118 PMC4423527__F1 Neddylation pathways influencing NFKB and HIF-1A 8454 8453 3458 PMC4428446__F2 Scheme of the signal transduction pathways that control C 998 27010 1473 PMC4429169__F1 Network uncovered using IPA 54541 50856 4915 7368 3726 374897 6769 3043 5584 4082 PMC4429650__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis 7018 1401 3603 4513 7412 3383 PMC4429713__F1 Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway 8726 545 472 PMC4436788__F12 Proposed model of arachidonoyl-CoA shunting in LPCAT3-deficient mice 10162 4018 5091 7038 PMC4439431__F2 Metabolism of a cell infected by HCMV 3156 47 2194 4513 PMC4439431__F3 Metabolism of a macrophage activated by immune signals 3156 47 31 2194 4513 PMC4440397__F1 Calcium channels in T cells 324 5335 6786 PMC4445746__F3 Predicted interactions between miRNA and mRNA targets within addiction relevant signaling pathways 10411 574038 574453 5581 100126333 PMC4448502__F4 Pathway analysis showed a strong role for early response genes and sterol regulatory elements 25791 7351 47 3885 10551 6720 6721 7450 51308 3727 5763 3991 1959 1958 4638 415116 7538 PMC4448604__F2 Drosophila Hippo pathway 351 7791 23513 23558 PMC4450280__F5 Estrogen regulates apoptosis signaling pathway of osteoclasts 840 839 835 836 3725 5602 842 834 837 843 637 581 331 841 6416 332 317 4214 8772 8717 355 56616 7185 7186 7187 PMC4450280__F6 Estrogen regulates MAPK signaling pathway of osteoclasts 834 835 836 839 840 6788 7850 841 842 5602 9448 6416 4214 3725 5599 5880 5058 5879 5062 998 PMC4451058__F2 Prostaglandin pathways in duodenal chemosensing 84890 50506 283871 64127 1080 PMC4452063__F1 The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper 6423 4040 4041 1499 324 607 PMC4452063__F2 The Wnt/Beta-catenin signaling pathway and the regeneration therapy drug candidates discussed in the paper 50964 4040 4041 1499 324 607 PMC4452147__F3 Schematic illustrations of a double-negative feedback loop and the ceRNA pathway 6935 5728 8091 PMC4453272__F2 Fragile X Mental retardation protein regulates several cellular functions in the dendritic spine 4763 5728 7248 7249 6009 3984 26523 1826 PMC4454164__F7 Proposed mechanism for RSV in the regulation of mtROS homeostasis through Sirt3 signaling pathway in HUVECs 3418 23410 6098 PMC4455918__F1 mTOR signaling pathway 2475 1977 1975 PMC4461463__F1 Scheme for arginase catabolism of L-arginine to L-ornithine/urea or L-citrulline/NO, production of polyamines and anabolism and catabolism of proline 4942 5009 435 PMC4461786__F4 Noncanonical Wnt5a signalling: a simplified view 6259 4920 7474 PMC4462002__F7 Fanconi Anemia Pathway 3398 545 84464 7398 56647 3978 PMC4462130__F6 a, Gene interaction map of Reactome pathway analysis that discovers alteration of FGFR signaling as the most altered pathway 10818 23239 8874 8074 2260 3845 112 2264 3084 5829 2251 11140 5894 2064 5156 3265 2066 5290 1445 5728 940 4193 5566 5293 3667 2931 2308 814 253260 PMC4464175__F5 Lipid biosynthetic pathways and interactions of phospholipid synthases and proteins involved in cell division 4018 1606 283871 5662 4026 1607 4049 PMC4465499__F3 Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications 2243 348 3240 9370 2934 717 7054 3105 7316 64782 PMC4465694__F8 Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells 6714 2475 2308 999 PMC4473262__F4 Human Blood Metabolome-Transcriptome Interface 10763 5624 5091 PMC4486076__F1 Autophagy in Autoimmune Disease 55626 2475 8408 9706 60673 9776 81671 9140 83734 10533 64422 9474 PMC4486731__F3a BRAF gene: From human cancers to developmental syndromes 2885 3845 4193 367 1019 PMC4488672__F5 Hierarchical signaling pathway expression regulates regeneration 3549 6469 1499 89780 2735 51176 PMC4488795__F2 Hepatic lipid homeostasis is regulated by LRP6 3949 4040 255738 355 79071 7038 PMC4490281__F1 Simplified schema demonstrating proposed mGluR–eEF2–AMPAR pathway: Postsynaptic binding of glutamate leads to activation of ionotropic (AMPAR, NMDAR shown) and metabatropic (mGlu1/5 shown) glutamate receptors 29904 2475 23237 1977 1938 PMC4490948__F2 IRE1–RIDD–RIG-I pathway 7186 7494 57506 PMC4491517__F1 Schematic diagraming central role of pyruvate in glycolytic, citric acid cycle (CAC), and accessory pathways 948 8473 23216 5091 7249 7248 2475 PMC4496162__F3 MicroRNAs in apoptosis, autophagy and necroptosis 5728 100302155 5163 406971 572 7248 7249 664 6009 64223 2475 847 693215 1998 83939 9140 PMC4496162__F4 MicroRNAs in apoptosis, autophagy and necroptosis 7186 8717 1540 7098 8772 192111 197259 759 PMC4496240__F7 Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways 650 581 4090 4086 4089 1647 1017 PMC4499569__F2 Neuroprotective cross-talk involving the cytoprotective PI3K/AKT pathway 3479 5163 65018 3667 PMC4499589__F7 EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury 7099 1969 3553 PMC4501477__F3 What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity 84126 472 545 9656 11073 9025 165918 PMC4503552__F1 Endocannabinoid system giving rise to endocannabinoids (2AG and AEA) and arachidonic acid and subsequently synthesis of prostaglandin glycerol esters, prostanoids, and prostamides 11343 2166 5742 5743 PMC4506602__F4 Chemical–protein interactions related to the VEGF signaling pathway 5319 8399 5320 3845 5532 5530 842 5322 5743 7422 5290 1432 5595 5747 4775 5533 PMC4508581__F4 Model illustrating the relationship between hypoxia, ER stress, and activation of the unfolded protein response 22926 7494 83939 468 PMC4508672__F2 HSV-I and the cellular DNA damage response 472 545 84126 9025 2177 165918 7518 PMC4510598__F4 Fatty acids biosynthetic pathway (map 61) 2194 52 3073 PMC4511633__F3 Hypothetical model of insulin resistance development in response to nutrition overload 50507 3643 3667 PMC4512107__F2 Let-7 targets insulin signaling pathway and thus inhibits cancer cell metabolism 355 5163 2475 253260 4609 3098 7249 7248 6009 10682 3939 1977 1975 PMC4513356__F1 Wnt Signaling in Dendritic Cells: Its Role in Regulation of Immunity and Tolerance 7097 10333 999 1499 50943 PMC4514105__F1 Cell death 355 8772 637 PMC4516161__F4 CIB1 regulation of TNBC cell survival and potential role of CIB1 in non-oncogene addiction 10519 5728 5058 PMC4516533__F5 Proposed model for EGFR-related signal transduction pathways regulating Snail in Ishikawa (A), Ishikawa ER- (B) and primary human endometrial tumours (C) 1950 1956 5058 2932 PMC4516574__F11 Hypothetical model illustrating p53 transgene mediated inhibition of Type I IFN signaling during VSV infection 6772 3661 7297 6773 PMC4518442__F3 Possible effects of soy isoflavone genistein and tea polyphenolic compound EGCG on the Wnt pathway in breast cancer stem cells 6423 4040 4041 324 595 26959 PMC4520659__F4 Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARA expression 8213 4060 5915 1381 1382 2171 PMC4522377__F1 Multifaceted Control of DNA Repair Pathways by the Hypoxic Tumor Microenvironment 545 472 3014 9656 5884 2177 55215 9874 672 PMC4523298__F3 Conserved and differential networks for the proteins in the PI3K-AKT kinase pathway between breast and ovarian cancer cell lines computed using a Bayesian FDR set to 0.10 1956 4162 3725 5728 4513 4255 PMC4532730__F8 High concentrations of photofrin-derived singlet oxygen triggers the generation of cell-derived singlet oxygen, catalase inactivation and intercellular ROS-dependent apoptosis signaling through the NO/peroxynitrite and HOCl signaling pathway 4025 847 27035 PMC4533766__F7 Expression profile of P 717 718 4255 53 93650 95 PMC4546915__F1 Adaptive stress signaling in targeted therapy resistance in cancer 2885 5728 5170 3667 5900 5898 5899 7249 7248 29110 998 9882 572 4193 5209 331 PMC4552299__F2 Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells 366 718 10578 58484 10301 79689 60675 124935 7124 8530 22861 54440 25903 942 941 50802 326624 962 25984 150372 PMC4552880__F1 Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis 375790 3339 3691 3913 9900 284217 10319 2812 2811 1301 255631 3918 7143 3673 3909 63923 960 1101 3694 3685 22801 51206 85301 3371 2335 7448 1280 1311 5649 3161 7058 7060 7059 3381 961 948 PMC4556940__F8 Network representation of microRNA 3725 3939 8061 34 4804 5834 56954 4817 1621 2261 4345 10229 47 5999 1392 92 2908 5733 796 5998 5996 7132 6348 776 5743 22949 7124 2562 7133 1012 2697 1241 1234 56666 361 2891 2563 7431 7040 3689 50507 2571 4049 1636 2892 2911 57085 847 4922 3557 5742 6506 PMC4562315__F2 Emerging roles of YAP and TAZ in cancer 7204 5728 6010 9113 26524 324 23513 4485 154796 23405 9686 PMC4562315__F3 Emerging roles of YAP and TAZ in cancer 4485 1499 9113 26524 25 324 8312 472 7161 581 8549 8313 PMC4562871__F1 Conceptual barriers to understanding physical barriers 999 3596 7124 PMC4564644__F1 Diagram showing the possible mechanism of serotonin mediated signaling pathway activated by BME during learning 121278 759 27161 1385 6855 627 PMC4564869__F3 Quantitative Phosphoproteomics Reveals Crosstalk Between Phosphorylation and O-GlcNAc in the DNA Damage Response Pathway 8473 642658 4397 PMC4568928__F1 Proposed model for multiple-target inhibitory action in TT cells 5979 5728 6714 2885 2475 673 PMC4572916__F1 Differential effects of Calmodulin on two key K-Ras4B effector pathways 23440 2695 1956 PMC4574966__F3 Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer’s Disease 7532 6194 26986 4082 7052 348 1410 154807 1876 1270 7161 50 64782 5686 5347 5701 4287 26471 PMC4576203__F1 Wnt/Beta-catenin cell signaling pathway 324 1499 2305 7088 PMC4576457__F7 Hypothalamic PKA regulates leptin sensitivity and adiposity 3717 9021 6774 5443 PMC4581967__F1 Evasion and Interactions of the Humoral Innate Immune Response in Pathogen Invasion, Autoimmune Disease, and Cancer 5648 720 727 730 729 1431 PMC4583193__F1 Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma 7039 3082 1950 2549 2885 2010 998 2475 5879 PMC4586018__F6 Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 156 8205 7038 PMC4586474__F3 TGF-Beta-IDO-SHP axis 3654 3620 7040 5971 196 7099 PMC4589110__F4 TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System 10628 5728 57716 4482 1838 PMC4589285__F11 Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney 7099 3265 9448 7046 8772 659 1956 3725 7157 4322 3717 PMC4589549__F4 Canonical Wnt pathway illustrating the roles of PITX2 dependant genes 27121 4040 324 85407 1499 4609 595 960 5308 PMC4589691__F6 Regulatory relationships of a KEGG gene set for the human T cell receptor signaling pathway in RegNetwork 3458 3586 2534 3565 1147 4792 3932 2932 5970 7124 8915 1437 5603 2353 1019 3725 4893 3845 961 7018 5058 5063 3265 PMC4590251__F1 PirB-mediated growth cone collapse and axon growth inhibition.A classical axon inhibition signaling pathway: Nogo on the oligodendrocyte surface binds to the NgR-LINGO1-P75 receptor complex on the neuronal membrane 84894 387 6010 PMC4593735__F1 Innate immune interactions within the central nervous system modulate pathogenesis of viral infections 115004 4615 114548 57506 29110 3661 83939 6041 3433 PMC4594510__F4 Schematic diagram for the signaling pathway involved in dexamethasone-induced TRPC4 channel activity 7223 3717 51655 342538 PMC4594598__F2 RhoGEF signaling pathways involved in 3D migration 4018 648 6714 4739 1795 55619 998 10276 387 5879 58504 5062 PMC4596921__F1 mtROS in bacterially triggered immune responses 7124 7189 197259 6772 51295 6647 6648 192111 PMC4597143__F4 Quantification of the full chemotaxis pathway 611 1901 9294 2768 10672 2775 2776 5091 5996 5997 5337 55022 9628 3635 8787 5578 324 1794 998 6002 5290 9138 9844 394 83478 5291 9181 5294 50649 56288 5295 9459 57580 23533 8874 200576 5728 1793 387 673 3611 5170 2185 5594 2885 1445 5599 2889 9564 3702 5590 2534 5604 10235 6714 6416 1398 5747 6197 4214 824 10152 3426 7430 7414 572 826 28964 2934 4638 7454 1499 1796 5829 1729 6548 8936 653361 2002 83706 10458 81624 10163 7114 10787 55845 55740 7791 2309 3725 4790 5970 PMC4598198__F2 effect of lipoxins on cytoplasmic signaling cascades and transcription factors.Notes: Lipoxin binds to its G protein-coupled receptor ALX/Formyl peptidyl receptor triggering a wide array of cytoplasmic signaling cascades 2475 7124 4664 1958 4353 PMC4598753__F1 Nuclear receptors can alter NFKB signaling and activity 7099 4615 7189 3661 PMC4599016__F5 Two separate GA13 Switch Region signaling pathways 387 6717 7175 10131 PMC4600925__F4 SGK1-mediated signaling pathway 5164 5163 65125 6446 PMC4601263__F5 CLN3 and sphingolipid signaling pathway interactions analyzed using Pathway Studio 7368 123099 1201 6609 253782 29956 PMC4601503__F3 Binding proteins 2475 5728 5163 PMC4605443__F2 The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective 54209 7006 100124696 4615 79930 6850 2885 PMC4606185__F1 Wnt/Beta-catenin signaling pathway in high glucose condition 4040 4041 324 1499 PMC4613518__F1 Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention 4094 9817 8452 9978 2730 3162 1645 PMC4620694__F1 Graphical summary: DNA repair proteins such as DNA-PKcs can be targeted to improve outcomes for patients with ovarian cancer 142 10038 672 56946 2188 5888 572 PMC4621504__F3 Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma 1500 1499 1496 4771 29119 23286 80014 10971 154796 23418 55841 324 9113 8313 26524 9817 4780 8452 1956 2066 5728 2263 2264 207 2475 7249 5156 10000 5159 4914 4915 4916 673 5894 4342 2322 4763 PMC4625378__F2 Ceramide is the hub of sphingolipid metabolism 10715 253782 91012 204219 29956 79603 1674 6611 PMC4627418__F5 Cytokine receptor interaction network for GBM survival 7852 4055 729230 4050 4049 6366 8764 8741 7124 8795 1230 8792 5473 1435 8797 1950 1436 3592 3579 1956 2056 3605 3552 2057 2690 3952 4804 3558 4254 5617 3953 3596 1437 3553 PMC4629004__F2 BCATm KO on protein synthesis pathways 27102 6141 6135 23521 6144 6138 9349 6152 6155 6143 6146 6157 6165 6169 6173 6132 1982 1977 2001 1983 83939 1975 1981 8663 8665 8667 10480 10209 1999 6217 6218 6223 6224 6230 6231 6235 3921 6188 6201 6208 6209 6222 6227 6229 6233 2197 6187 6203 6192 6204 6206 6193 6210 6202 3667 54541 4553 6194 1998 6196 151742 5518 5523 5525 8668 8666 3646 8664 27335 8662 51247 PMC4629004__F3 Changes in genes encoding components of the glycolytic, TCA cycle, and mitochondrial NADH shuttle pathways in gastrocnemius muscle in response to BCATm KO 6517 3099 5213 2821 226 8789 5230 2597 5224 2027 2023 9123 5315 3939 3945 6566 4191 1431 50 3418 6389 6390 6392 6391 3421 3419 4967 1738 8803 8801 8802 2819 2820 8604 2805 2806 8402 PMC4629839__F1 MTOR pathway 2475 8544 253260 3667 7248 7249 6009 29904 1977 1975 PMC4630008__F1 Diagram of Hh signaling in mammalian cells 4193 8829 51684 1950 51715 11197 91653 2619 2719 8452 83737 26292 6774 648 595 596 9429 156 6608 PMC4632280__F7 RAC3 regulates cellular senescence and aging 2475 23411 5881 PMC4638128__F2 Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? 142 9156 5426 3978 PMC4638128__F4 Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? 9156 3981 5888 5426 PMC4639861__F9 Model for Grhl2 function in coordinating differentiation and morphogenesis of airway epithelium 79977 4854 57228 79755 4602 345643 5990 2302 PMC4640466__F2 Noncanonical Wnt/calcium pathway 4920 6259 23002 387 998 51701 PMC4641965__F1 Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity 51094 79602 5465 7351 PMC4642568__F2 RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli 1540 54941 9140 5300 134285 9641 3661 10010 8517 57506 1147 3551 4793 4790 7186 6300 PMC4644789__F1 Interplay of TrkB and GR signaling pathways in the CNS 1392 627 2638 126669 200186 2642 PMC4658488__F1 Cholesterol biosynthetic pathway and cholesterol synthesis inhibitors used in the current study 3156 4598 10654 3652 3422 91734 50964 4047 1718 6309 1717 PMC4660682__F5 Relative functions and pathways in DN 336 1435 928 1950 427 3572 290 354 7295 3959 1401 3952 57817 PMC4664160__F4 Druggable Sensors of the Unfolded Protein Response 83939 10628 468 596 4170 114548 581 PMC4666670__F4 Transcriptome Analysis of Plant Hormone-Related Tomato (Solanum lycopersicum) Genes in a Sunlight-Type Plant Factory 4015 48 10006 4881 PMC4668392__F1 Multiple regulation pathways and pivotal biological functions of STAT3 in cancer 6714 5879 998 6774 PMC4671321__F5 Predicted model for the action of GSK3B in buffalo embryonic stem ( ES ) cells 22943 3976 3977 2885 2549 1499 79923 PMC4671727__F1 Complement Effectors of Inflammation in Cystic Fibrosis Lung Fluid Correlate with Clinical Measures of Disease 718 717 727 729 PMC4673281__F6 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic 51701 9350 324 4089 4088 25805 50964 3952 6500 8454 9978 387 9475 3458 7057 4052 10468 5308 4838 PMC4673467__F2 Wnt signaling pathways 324 1499 6010 PMC4673555__F4 Proposed GC-C signaling in colitis 6927 2981 2984 6550 1080 1260 5593 5139 3172 1045 PMC4674888__F12 LRRK2 in neurons in Parkinson's disease which is the fifth scored pathway map in MetaCore enrichment analysis results 120892 2932 2011 161 160 4905 5962 4478 PMC4674888__F8 Development Hedgehog Signaling which is the top scored pathway map in MetaCore enrichment analysis results 6469 55733 84976 50846 3549 2619 50937 91653 5727 51684 11140 55582 156 27148 10284 2735 2736 2737 8650 1499 9978 8405 6502 PMC4674888__F9 Development WNT signaling pathway Part 1 1601 6502 9978 6925 2932 324 1499 PMC4679438__F3 mTOR and its tight regulation for iNKT cell development and effector function 7249 5163 6009 7248 790 1977 PMC4680051__F2 Metabolic networks placing mitochondria at the center of anabolic and bioenergetics pathways in cancer cells 3939 26227 3418 PMC4681601__F1 Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy 3815 3620 9021 196 405 2475 3659 324 920 54106 7099 50943 PMC4682245__F5 DEGs involved in JNK pathway in Tg(RE:HSE:EGFP) 2316 3727 1386 2002 4149 4208 PMC4683003__F1 Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferi 3422 10654 4598 PMC4683444__F5 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity 8717 1147 7186 7124 3667 9021 4790 3953 5465 6774 4852 3717 5443 4254 3265 5604 3815 5894 1638 PMC4685734__F5 Apoptotic cell recognition receptors and scavenger receptors 4035 84466 391 5880 5879 387 7409 PMC4687899__F2 Pancreatic Cancer Metabolism - Breaking it down to build it back up 6510 2744 3099 3098 2806 2746 2805 2673 22934 6120 4190 4199 5163 3939 PMC4688896__F1 Dysregulation and restoration of translational homeostasis in fragile X syndrome 5163 5164 7249 7248 6009 1975 1977 2475 PMC4688904__F1 The glucocorticoid receptor, regulation of gene expression, and its clinical consequences 6095 9575 5430 PMC4693471__F2 Gene‐by‐age interaction miRNA–mRNA network analysis 6855 6812 6844 6616 5747 7852 91653 4908 10814 4929 442909 6586 627 214 9423 57142 51299 2290 288 1641 2619 23077 4851 9253 10505 474 596 1002 1951 8648 4487 22885 7005 26064 84441 51665 4853 10138 8525 2308 4094 3146 256297 9881 116986 9968 85358 57057 26115 64324 23390 6314 6496 23253 51176 56899 126626 7391 64332 2000 133522 9219 23314 3172 56155 PMC4694682__F5 Polyphenols activate Keap1/Nrf2/ARE pathway and increase the expression of detoxification/antioxidant enzymes.Notes: In the cytoplasm, Keap1 protein is always bound to Nrf2 transcription regulator and prevents its signaling 9817 847 57716 PMC4694848__F7 Thioredoxin 1 mediates TGF-Beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma 7295 2932 999 1000 PMC4694849__F4 PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines 1893 5728 5290 5293 7248 6009 2475 5579 PMC4694912__F3 MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model 4292 2956 6119 5111 6117 6118 472 3630 113455421 63922 114799 9126 1431 PMC4694980__F4 Core of kinase-regulated interactomes defines the neoplastic MDSC lineage 6390 1509 8407 7173 79026 11335 4869 92140 PMC4694985__F3 The respective drug targets in the overall architecture of molecular interactions for the top pathways correlating with response to Pazopanib A 468 472 25 1385 2194 5888 3725 5979 7249 7248 2475 1977 3667 5728 PMC4696015__F2 Androgen pathway resistance in prostate cancer and therapeutic implications 367 5728 2475 PMC4696186__F2 Molecular mechanisms linking ciliogenesis and cell cycle regulation 8481 347240 80184 146057 57787 1611 54820 4750 3796 10013 4751 5347 56623 PMC4697456__F1 CAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis 2828 9541 3084 5551 PMC4699200__F9 TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGFB Receptor Pathway in Human Aortic Endothelial Cells 4023 7046 4087 467 4088 4089 PMC4700430__F2 Blood-based gene expression signatures of medication-free outpatients with major depressive disorder: integrative genome-wide and candidate gene analyses 759 49 100170220 1312 PMC4701046__F2 Signaling pathways in melanoma 2776 4763 4893 673 5728 998 572 2475 4286 595 PMC4701972__F2 Regulation of the Hippo pathway by upstream signals 9344 51347 57551 4771 4485 6010 9113 26524 983 PMC4705829__F1 Signaling crosstalk between the mTOR complexes 3667 253260 64798 2475 9675 64223 5879 5163 7249 7248 51256 6009 11201 84232 1977 1999 27250 29904 1975 PMC4706528__F1 PI3K/Akt/mTOR (PAM) pathway and inhibitors of the pathway tested in phase I-III clinical trials on solid tumors and/or breast cancer 5728 2475 8821 5163 7249 7248 1021 1019 PMC4706927__F5 Putative inhibitory pathway of macrophage-mediated inflammatory signaling responses, as suppressed by KTH-13-AD1 7099 4615 6714 4703 PMC4712330__F3 PTEN tumor suppressor gene and its role in lymphoma pathogenesis 5163 3667 4734 5728 7249 6009 9961 5901 2475 1060 5888 PMC4713514__F5 Focal adhesion pathway analysis based on the KEGG database 387 7408 3611 5728 2534 1398 126669 572 PMC4713713__F3 Activation of autophagy and caspase-independent apoptosis pathway and proposed mechanism of action of magnetic nanoparticles functionalized with LL-37 on colon cancer cells 581 9474 10533 2021 PMC4714660__F4 Cell death pathway in tumor cells 1311 7098 1540 197259 192111 8772 PMC4716095__F1 mTOR signaling 5163 7248 7249 6009 6446 PMC4721539__F1 Dissecting Germ Cell Metabolism through Network Modeling 1544 24 56603 54884 64220 221223 151056 1066 23491 3991 5406 9227 123 3949 55022 PMC4722285__F6 Schematic model of downstream signaling after GPCR activation 5879 2695 5335 PMC4728676__F1 Molecular and cellular mode of action of energy disruptors 5728 7249 26227 10645 PMC4736186__F11 Schema of signaling pathway involved in IL-1Beta-induced inflammation in microglia 3553 3554 7099 4615 4513 PMC4737002__F1 Regulation of interconnected stem cell signaling nodes by the AR 6352 5728 367 6774 4087 4088 79923 9314 PMC4739752__F1 Repression of DNA-damage signaling pathways at telomeres 472 3014 9656 165918 55183 10459 545 142 11201 3980 3981 6873 25913 7517 5888 5893 PMC4742122__F6 The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets 1950 1956 6714 10397 5879 2973 PMC4744706__F2 Key players of the mTOR complex1 cascade in LR asymmetry Cartoon depicting a simplified model of the TORC1‐dependent signalling pathway and its physiological outcome 2932 7249 7248 8408 22863 PMC4747347__F2 Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose 23400 65018 9140 64422 9474 10533 693180 8408 9706 9776 83734 2475 PMC4747503__F5 Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea 4647 59330 1431 PMC4747889__F3 Highest confidence network constructed with differentially methylated genes by proton beam treatment on the MCF-7 cell 7554 1058 23468 114625 7320 201299 55578 2968 8531 2959 9183 9994 150684 6237 3155 154091 100529239 2542 28511 84859 10910 2764 6251 79598 PMC4748851__F2 Neurofibromatosis type 2 960 1956 6010 998 8663 5900 PMC4752998__F1 Epithelial/mesenchymal status of MCs is due to the balance of signals delivered by multiple receptors 655 3082 4087 4088 4090 4086 6774 6010 999 3553 PMC4760064__F3 Gene regulation by peroxisome proliferators (PPARs): the most significant pathway from Crohn’s disease (CD) 54205 1843 3725 2353 7018 3569 6667 3949 6348 PMC4761518__F1 F-BOX proteins in cancer cachexia and muscle wasting: emerging regulators and therapeutic opportunities 2660 3479 3667 7249 7248 2475 PMC4762141__F5 Different gene expressions in regulation of actin cytoskeleton pathway in AuNR-treated MDA-MB-231 cells 2147 3630 2335 55970 1398 1445 10672 673 5605 22800 7454 324 387 10152 28964 5829 7414 10298 10458 10163 3985 1730 2934 PMC4762491__F2 Man-P-Dol acts as mannosyl donor for the synthesis of M9-DLO, GPI anchors, and C- and O-mannosylated proteins 8818 8813 54344 79644 10195 2821 PMC4763954__F1 Fas:FasL interactions 355 8772 7185 PMC4765324__F5 Programming and reprogramming neural cells by (endo-) cannabinoids: from physiological rules to emerging therapies 4803 1499 5080 7442 468 57761 467 PMC4770774__F9 Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis 9242 3488 3480 56062 PMC4773096__F1 Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways 5728 2885 2475 5163 6009 7248 PMC4777469__F1 Genes and miRNAs involved in the regulation of the intrinsic and extrinsic apoptosis pathway 920 8772 581 331 PMC4779258__F6 Ozone-induced lung inflammation and role of IL-6 signaling pathway: ozone-associated lung inflammation is primarily driven by lipid ozonation products (LOP) and generation of free radicals primarily in lung epithelial cells 3569 6774 3717 3570 PMC4781997__F3 Apoptosis through death receptors: a signaling pathway in TLE(HS) 840 7157 5970 8797 8771 5925 4792 841 7132 PMC4782360__F3 Pathway analysis illustrating the link between PM2.5-associated miRNAs in extracellular vesicles and biological pathways related to cardiovascular disease 958 1435 1232 6387 3576 7852 84639 27179 27177 56300 26525 3569 4314 5155 7412 PMC4783780__F8 Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite 5996 6001 108 113 5997 8786 109 5998 10636 196883 115 759 5999 6004 26575 148 153 9628 64407 154 6000 10287 1131 779 155 8601 5566 8787 4047 7529 2810 10971 3760 7531 818 3762 7533 7534 5331 7532 817 3745 5569 805 5570 808 11142 845 3709 81693 811 3710 2782 59345 6262 408 2783 6263 409 2784 488 2280 489 2792 2788 54331 94235 5587 5350 2785 2791 11 2786 55970 2787 51764 4666 782 486 784 717 2697 2705 2706 2701 84694 2707 127534 2709 10804 PMC4788929__F6 MELK and stathmin signaling 2885 126669 9833 PMC4797366__F3 Wnt signalling in energy balance regulation 4040 3953 2932 8313 PMC4803789__F2 Molecular regulation of autophagy 596 9140 10533 83734 9474 23192 64422 7405 26100 8408 55054 9776 60673 PMC4810089__F2 Kinase signaling pathways involved in T cell receptor activation 940 920 9021 2534 3932 7535 6461 2885 867 1445 3702 27040 3716 3717 7006 100124696 5335 5728 5879 2922 8915 2475 5778 2353 2002 1051 2309 2308 2152 861 864 1050 PMC4810089__F3 ARE- and GRE-signaling pathways stimulated through growth factors and growth hormones 5999 6000 5997 6001 2887 2534 5747 2885 6714 5728 1445 1633 2475 7465 1019 1977 8844 4609 6667 1051 2353 2002 3725 PMC4811695__F1 Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects 4855 4853 4851 4854 2887 5728 2932 7249 6009 9675 2475 64798 64223 PMC4811737__F1 Cellular and molecular mechanisms implicated in regulating the balance between tolerance and rejection in the mouse liver transplant model 3458 355 942 941 PMC4819695__F1 MYC: regulator of post‐transcriptional mechanisms 2091 4691 23451 8896 6426 27343 11201 4149 4609 PMC4822552__F4 Serum transferrin carrying the xeno-tetrasaccharide NeuAc-Gal-GlcNAc2 is a biomarker of ALG1-CDG 51083 56052 91869 2592 PMC4824422__F3 Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling 952 814 5137 1131 5333 154 9630 6196 4914 774 5025 491 6197 7850 775 2915 5733 776 23542 4763 135 1812 778 2925 552 8913 55799 3265 8912 3363 1139 783 673 8911 5021 2903 5579 627 4843 2902 2778 4208 2066 5350 3356 23236 2885 5894 PMC4826038__F3 Serpinin/pGlu-serpinin formation, its signaling pathway and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells 1081 107966124 6667 PMC4826168__F2 DAB2IP in cancer 8717 153090 6714 2932 2475 1499 1958 6935 PMC4831116__F1 An overview of plant hormone signaling networks and their crosstalk in stress responses 4881 2077 5863 4609 4602 PMC4831273__F9 How the source and context of activated GAs and cAMP may determine whether they enhance or inhibit TCR-stimulated IL-2 transcription 759 920 940 27040 3932 5335 PMC4831844__F2 Computational Reconstruction of NFKB Pathway Interaction Mechanisms during Prostate Cancer 6615 5970 8676 9592 374 650 6236 3659 5743 5209 5806 3976 2840 2921 PMC4832112__F1 Necroptotic pathway 1540 7186 8717 23118 10454 7098 8772 197259 PMC4833098__F3 Canonical PPAR signaling pathway 65057 5360 1376 7350 3611 7316 364 4023 PMC4834358__F1 Molecular pathways and targets of the epithelial–mesenchymal transition 6608 5727 3611 2932 7189 1499 2735 3091 999 7291 117581 1000 6935 9839 PMC4834358__F2 Hexosamine biosynthetic pathway (HBP) and glycosylated EMT targets 999 1000 6608 6615 1499 PMC4839493__F7 1,25(OH)2D3-induced signaling pathways involved in the regulation of cell proliferation, apoptosis, and inflammation in cancer 1956 324 581 759 847 7421 595 3569 1017 999 PMC4839647__F3 A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer 4953 6723 6303 262 6611 54498 2194 31 32 47 1431 50 8801 8803 6389 6391 6392 PMC4842122__F1 Signaling pathways involved in SSc pathogenesis that may also play a role in EndoMT 4088 4089 4087 6469 3091 5727 6608 4851 PMC4844344__F12 SIG5 expression control in the light-signaling pathway regulating the expression of the chloroplast genes psbD and psbA for the photoreaction center II core proteins D1 and D2 in response to light intensity and quality 1407 1408 64326 PMC4849044__F2 Schematic diagram illustrates the role of matrilin-3 in ECM modulation of cartilage 4148 650 4086 4312 4314 4322 3553 11096 4513 9507 PMC4850162__F2 Riboclustering-mediated signaling pathways that regulate innate inflammatory modulators, including cytokines/chemokines 7100 7099 7097 7098 2972 PMC4852160__F1 Adenosine monophosphate-activated protein kinase (AMPK) activators for the prevention, treatment and potential reversal of pathological pain 3569 4803 7249 7248 1977 PMC4855107__F1 Arachidonic acid (AA) metabolism involved in the pathogenic mechanisms of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity 4512 5228 5226 4049 4050 PMC4855182__F6 Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2/SMAD signaling 650 860 9242 PMC4856717__F1 Main pathways involved in CD40-TRAF signaling 958 6347 7124 941 942 PMC4863711__F2 An overview of different signaling pathways activated by high glucose ambience, which leads to an altered expression of various ECM glycoproteins, and of genes relevant to EMT and apoptosis processes 6279 7097 7099 4615 2475 2932 324 1938 1499 PMC4866511__F7 Endosomal System Genetics and Autism Spectrum Disorders: A Literature Review 5728 5163 7248 6009 7249 PMC4868425__F8 The GLUD2 genotype effect on mouse metabolome 25796 2747 1387 PMC4872805__F1 Sirtuins as regulators of metabolism and healthspan 983 23411 9611 2308 5465 952 10038 3090 PMC4874901__F8 JNK mediates mouse liver injury through a novel Sab (SH3BP5) dependent pathway leading to inactivation of intramitochondrial Src 6714 7124 55715 PMC4878431__F2 Schema of IR structure and insulin signaling pathways in vascular cells 3630 2885 7412 PMC4879160__F4 Sclerostin actions 4040 4041 4038 5741 PMC4881378__F1 Components of the TLR signaling network frequently mutated in lymphoid neoplasms 7100 7097 10333 4615 114609 51135 57161 7189 7187 1540 23118 257397 10454 1386 4609 PMC4881575__F1 miRNA network regulating cancer metabolism 442917 5728 2475 4609 355 100126349 494336 PMC4882535__F4 Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine 3934 50855 5578 5584 81027 387 3909 5595 5241 2099 836 5594 3576 7422 56288 7430 4478 3791 60 5962 1287 842 2335 PMC4882600__F8 RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells 650 11186 4485 60485 5163 9113 26524 2932 1021 1019 595 PMC4882719__F2 Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy 581 1956 5728 PMC4884928__F4 Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state 4172 892 4502 1312 5925 595 5311 405 5443 4520 5702 5228 207 1499 7422 55578 2096 54578 4940 351 627 7124 4599 3665 6469 6500 1557 59349 23481 3606 5901 8607 26999 1673 1435 5743 1950 4855 387 3551 5594 2353 3603 2720 9927 4629 3725 718 629 1675 3672 4602 652 4637 5501 10410 7430 5210 79784 388 1736 5781 10398 7358 4852 PMC4893057__F1 Sequence elements and protein components involved in the formation of poly(A) tails 1356 11201 5426 PMC4895609__F1 Simplified schematic illustration of PI3K/Akt and mitogen‐activated protein kinase (MAPK) signaling pathways in thyroid cancer 5728 673 2475 PMC4896389__F4 Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence 51665 7046 7422 5281 6387 7852 3627 4283 6373 58191 940 941 942 3082 8205 PMC4899597__F1 Canonical Wnt signalling involves binding of Wnt to LRP5/6 and its coreceptor Frizzled resulting in the phosphorylation of LRP5/6 thus permitting Axin to bind to the receptor complex 4040 4041 1499 7008 PMC4904011__F1 Protein pathway driving the migraine process at the tripartite synapse 4513 23245 4209 9457 6616 112476 PMC4905226__F2 (See previous page) 142 4361 7518 7515 472 PMC4905302__F1 Autophagy regulatory pathway 9474 9140 83734 9776 10533 64422 22863 PMC4905465__F6 Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome 3458 7045 7422 5465 196 939 916 3725 2353 5915 5914 1879 1051 914 8581 4061 213 83639 29760 7124 406947 919 925 3107 5077 4062 3558 7374 54742 PMC4912847__F1 Exosomes in liver pathology 29102 963 967 975 3732 PMC4916957__F2 IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance 64218 8829 5728 PMC4917114__F7 An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy 596 1272 3569 2627 5054 5743 652 PMC4917665__F2 Metabolic pathway of aerobic glycolysis, FAS and FAO 3099 2194 3939 1376 4199 47 PMC4918232__F2 B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292 613 4067 973 695 6850 2475 PMC4918253__F1 Schematic view of the TLR4 signaling pathway.Notes: Upon binding of lipopolysaccharide (LPS) to the TLR4 complex (TLR4–LBP–CD14–MD2), TLR4 signals through MyD88-dependent and/or MyD88-independent pathways 7099 3929 929 114609 4615 7187 7189 29110 3661 3553 PMC4924289__F1 Summary of the signalling pathways known to control the switch between dauer and growth in C 3630 9798 54704 3479 207 208 5163 9437 9436 PMC4926172__F1 Schematic overview of viruses that subvert the PI3K/Akt/mTOR signaling pathway 3688 5728 5163 7249 7248 2475 6009 PMC4928052__F3 Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma 8540 55224 1119 8443 5833 10555 5091 55627 PMC4931096__F1 Biosynthetic pathways and the transformation of H2S in the mammalian body 5212 875 847 1610 PMC4932542__F1 Models that have been proposed to explain the inhibition of tumor cell proliferation by metformin 3479 3417 3418 PMC4933865__F6 Multiple modes of action of Mg2+ in attenuating Pi-induced VC in HAVSMC 54822 846 860 4086 1499 4256 PMC4937866__F13 AhRR repression on AhR activity and the consequences in endpoints 196 7018 57491 405 PMC4938382__F2 Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas 6850 3702 6095 2196 10979 84465 4958 56147 56832 27020 342035 640 324 51199 2241 7010 29930 4208 176 1462 5730 2564 2554 2039 9607 2743 154 6781 3596 2307 1393 1508 6440 2218 210 6678 9314 18 60490 4489 4495 7054 6652 PMC4939268__F1 Metabolites involved in Glycolysis and Amino Acid Metabolism are Altered in Short Children Born Small for Gestational Age 7124 3033 5625 6195 4023 PMC4940389__F1 Regulation of HH and Wnt/Beta-catenin signaling by 1,25(OH)2D/VDR and calcium/Casr 6469 6608 5727 999 1499 7421 1593 120227 5212 PMC4942188__F1 Targeting lipid metabolism for the treatment of Anaplastic Thyroid Carcinoma 1950 7248 7249 5163 2475 2194 6319 3156 3949 6009 948 PMC4944539__F1 FGF/FGFR signaling pathways 2885 10818 2549 6654 PMC4951124__F6 CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling 1956 6387 7852 6714 4088 4089 PMC4955761__F8 Pulmonary Epithelial Toll-like Receptor 4 Activation leads to Lung Injury in Neonatal Necrotizing Enterocolitis 7099 3146 6374 PMC4957615__F1 Actin and myosins in mammalian autophagy 8887 10133 4646 718 4641 123720 PMC4957946__F1 Differentiating mTOR Inhibitors in Renal Cell Carcinoma 2475 1950 3479 1956 3480 5163 5728 253260 7249 7248 64223 6009 7428 29904 27250 1975 1977 PMC4959856__F6 VNN1 expression and function can be regulated by Ox-LDL to promote atherosclerosis 8876 9619 19 4864 7412 3383 PMC4959859__F8 Schematic mechanism of L5 on STRA6 cascade suppression and kidney injury 7276 5950 64220 PMC4960866__F1 Overview on the role of apolipoprotein E (APOE) in the three main pathways of plasma lipoprotein metabolism 348 249 3949 4023 PMC4961262__F1 The SDF1/CXCR4 signaling pathway 7054 6862 140805 6899 6091 2253 6469 2260 PMC4962007__F3 Willin, merlin and ezrin are all FERM containing proteins that can influence proper functioning of the cytoskeleton, cell to cell junction complexes (TJ: tight junctions, AJ: adherens junctions) and the hippo signalling pathway 4485 9113 26524 PMC4964517__F4 Upregulation of melanogenesis by SOX9 6662 4286 1638 PMC4964535__F1 Mechanism and pathway map of the prostate cancer (modified based on KEGG database) 367 960 1017 572 5728 3082 4193 7052 596 2444 2146 6657 79923 PMC4965087__F2 Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment 1017 1647 545 355 572 4609 637 836 842 4193 64065 3486 1039 50484 7249 5728 900 64326 6477 901 PMC4970823__F2 Regulation of cancer cell functions by hyaluronan (HA)‐receptor interactions 960 1969 10207 6010 PMC4971466__F4 Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala) 4086 4089 3458 64750 57154 6500 1616 387 PMC4972490__F1 BRCA1 and BRCA2: different roles in a common pathway of genome protection 3014 9025 9656 672 545 472 83990 11073 79728 675 5888 5893 PMC4977841__F1 Hedgehog signaling inhibition by the small molecule Smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b 6469 6608 51684 2736 PMC4983259__F1 O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling 2475 5728 8473 10724 3099 3939 5163 5209 47 2194 PMC4985172__F2 Intracellular signaling pathways of EET’s 6774 1950 6714 59341 PMC4988275__F1 Cellular and molecular events of autophagy–lysosomal pathway 2475 9776 83734 64422 10533 9474 9140 PMC4991391__F1 N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications 1956 324 3845 1499 673 4089 596 581 207 4088 4087 595 2475 PMC4992436__F1 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology 7124 7186 7188 5970 3553 PMC4997237__F14 Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures 2885 472 2934 83939 6157 6141 6138 2001 1983 6155 6124 11224 8665 6175 2000 6187 1999 PMC4997391__F4 Urinary Metabolomic Approach Provides New Insights into Distinct Metabolic Profiles of Glutamine and N-Carbamylglutamate Supplementation in Rats 162417 1373 5091 435 PMC4997642__F1 Canonical Wnt signaling pathway (reproduced with permission from) 999 1499 324 PMC5006677__F1 The Akt/mTORC1 signaling pathway leading to accelerated translation and increased protein synthesis 3479 5163 3667 7249 7248 6009 PMC5008583__F3 KEGG in Graphviz view of T-cell receptor signaling pathways on a canonical signaling pathway with gene methylation chip data 1493 5530 1739 5133 1432 4773 7535 919 868 2534 916 5800 3932 7409 3702 920 387 3937 27040 7038 4690 5058 5335 8915 2885 940 6654 1147 4792 8517 4790 5290 3551 29851 208 959 1326 9020 2353 3845 5604 5894 PMC5009326__F3 Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s disease 22938 3280 2033 171558 23385 5663 9612 6868 9369 6464 348 351 8650 5906 5015 23493 8766 2665 8850 3065 1387 55534 2648 PMC5010773__F1 Representation of Canonical Wnt/Beta-catenin pathway 1499 324 759 6010 595 4609 PMC5011664__F3 Regulation of wingless/int-1 signaling by crosstalk in hepatocellular carcinoma 3479 6711 4089 4088 2932 8313 1499 3082 999 595 PMC5012644__F2 Hypoxia-inducible transcription factor (HIF) pathway in clear cell renal cancer 6923 7428 6921 55193 8314 29072 PMC5012964__F2 Molecular pathways underlying the development of the male external genitalia 2253 655 3209 3239 650 7474 6469 1499 2255 652 PMC5016689__F7 Proposed model for the impact of CCL2 on HDL internalization and cholesterol efflux and regulatory mechanisms in HCAECs 6347 1232 729230 1234 335 PMC5019383__F3 DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions 27040 472 29760 613 6850 4067 7189 331 8717 373 3929 929 114609 4513 29949 7099 1270 1950 4803 4049 4050 5971 338376 PMC5027689__F1 Fanconi anemia (FA) DNA damage repair pathway 57697 91442 84126 1196 545 80198 146956 197342 2187 84464 80233 2175 55215 55120 2176 2177 2178 2189 641 29089 2188 353497 675 11201 51426 4292 5395 PMC5033061__F6 An integrative analysis of the InR/PI3K/Akt network identifies the dynamic response to Insulin signaling 2022 1499 6950 5984 5985 5983 5982 100187907 54487 9611 1636 1999 29102 7088 154796 PMC5036407__F6 Illustration showing the mechanism by which NDRG1 mediates activation of the Wnt signaling pathway 1499 10397 324 7089 PMC5036969__F3 Mitochondria and Cancer 2475 5728 7528 PMC5037772__F4 Pin1 has biphasic effects on insulin signaling 5300 3667 5266 PMC5037772__F5 Pin1 regulates multiple signal transductions in metabolic organs 200186 3667 6774 4087 5300 4208 860 81501 1499 PMC5041507__F1 Pathway interaction network of targets of apoptomiRs in breast cancer 2028 5581 6623 6242 5893 23171 114783 387 3939 51742 157567 7186 301 3654 898 836 23657 7189 599 2475 596 10197 4582 4170 10620 27250 595 2113 598 7168 1955 2308 7157 2146 6198 5728 558 5292 8061 4851 2309 23411 51603 1457 2056 2057 54619 10397 7078 8897 1025 92140 94241 PMC5043614__F2 Links between altered glucose and phosphatidylcholine metabolism in breast cancer 1956 2475 7157 2539 355 4023 PMC5045091__F2 Modification of the HIF-mediated switch to anaerobic respiration in osteoclasts.Notes: Osteoclasts specifically increase flux through both the glycolytic pathway and mitochondrial ETC to provide ATP and ROS necessary for bone resorption 5163 5210 230 4772 PMC5045388__F4 Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer 369 2475 1906 PMC5048723__F4 Signaling pathways associated with differentially methylated candidate genes were predicted by Ingenuity Pathway Analysis™ 113189 7480 2353 7163 PMC5054714__F1 DEGs in p53 signaling pathway Up-regulated and down-regulated genes are color-coded in red and green, respectively 1017 10090 545 572 5728 PMC5057284__F3 Circadian oscillations in intracellular organelle’s structure and function 406 7507 472 5187 8864 468 9575 7494 22926 51024 8408 10135 1407 PMC5059456__F9 Regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways 8323 324 2932 6774 1499 6925 PMC5067532__F3 Hydrogen sulfide in DN 50507 2475 875 PMC5070770__F8 Fine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway 51176 7089 4851 182 23462 PMC5071109__F4 Cell-free Xenopus egg extracts for studying DNA damage response pathways 545 84126 11073 5884 51455 PMC5077967__F8 microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NFKB 1435 1440 8717 5971 5970 5966 2002 2920 3383 4286 597 PMC5081117__F6 Targeted transcriptomic analysis 1610 130013 3939 1152 191 58478 1962 3620 8942 23498 6999 51074 4548 262 790 6303 4507 847 51056 2628 51166 635 79814 15 56954 95 3155 435 4942 1629 5832 549 587 5471 2806 5162 PMC5083749__F1 Upstream and downstream signaling in the mTOR pathway 3480 2261 1956 6755 5728 673 2932 2475 581 472 1616 546 7428 4255 PMC5084677__F8 Proposed model for the accumulation of BRCA1 complexes at DSB sites 9025 165918 672 580 55183 PMC5085755__F3 Functions of three members of the UBXD protein family (UBXN1, P47, and FAF1) that are potentially involved in the prevention of cancer 51035 8717 7186 11124 PMC5088520__F1 Path2enet: generation of human pathway-derived networks in an expression specific context 3955 5986 1855 1856 1857 9794 84441 8650 9253 1387 1840 113878 151636 55534 22938 28514 10683 54567 3280 196403 8850 23220 388585 11317 171558 5663 55851 5664 23385 51107 9612 182 1487 3714 1488 PMC5094499__F1 Pleiotropic effects of hyperglycaemia‐induced miR‐126 underexpression and insulin resistance 3667 5163 5728 5894 161742 PMC5094977__F7 Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines 7124 3569 3458 6464 5925 596 5728 581 331 836 840 598 PMC5096733__F1 Simplified diagram of mTORC1 and ERK1/2 signaling following muscle contraction 29904 6194 1938 PMC5102338__F6 Diagrammatic representation of possible mechanistic pathway for the induction of EGID 920 6778 7039 PMC5103287__F1 DGKA and DGKζ in T cell activation and anergy 940 1606 5335 10125 1958 2308 1959 8525 PMC5115734__F1 Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement 210 7390 7389 1371 5498 2235 PMC5115891__F3 Comprehensive transcriptomic analysis of differentiating embryonic stem cells in response to the overexpression of Mesogenin 1 2475 3725 208 2736 84667 3280 PMC5116470__F1 Some of the known pathways linking DDR to autophagy 472 5728 7249 64798 2475 8408 9776 PMC5126119__F2 TLR-4/LPS signaling pathway activated by LPS in ALD 3929 3654 51135 7189 3661 1958 929 4615 PMC5129910__F8 Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts 23411 3482 3480 PMC5130266__F10 Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling 4087 4088 9759 10014 PMC5139348__F3 PI3K Pathway in B Cell Metabolism 84329 6850 5728 60468 PMC5140782__F1 Metabolic rewiring in melanoma 6470 26227 1719 3939 4609 51660 25874 57546 5163 29920 5831 2806 3417 84706 2744 2746 4942 65263 2805 5105 440 6510 PMC5140782__F2 Metabolic rewiring in melanoma 4763 673 3155 4286 PMC5140782__F3 Metabolic rewiring in melanoma 387 2936 6647 2879 6648 2876 160428 PMC5141431__F4 Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism 23475 10135 203447 4837 PMC5142153__F1 Summary of extrinsic, intrinsic and membrane stress apoptotic pathways 8772 472 581 4193 PMC5148674__F3 The p53 tumor suppressor in metabolism and diabetes 387 6236 27165 2593 5225 PMC5149523__F1 Effect of PD-1 on major signaling pathways and subsequent metabolic reprograming in T cells 324 3932 10125 5728 2475 27040 PMC5149523__F3 PD-1/PD-L1 blockade enhances tumor rejection by activating T cells 3932 10125 2475 27040 PMC5159240__F1 Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu 5163 5728 2885 572 3297 2002 2113 2353 6667 4609 3725 1758 595 4193 PMC5161243__F7 Downregulation of a GPCR by Beta-Arrestin2-mediated Switch from an Endosomal to a TGN Recycling Pathway 2695 367 2696 PMC5173100__F8 Novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway 1017 890 1021 1019 PMC5191957__F2 Carcinogenic Effects of Oil Dispersants: a KEGG Pathway-based RNA-seq Study of Human Airway Epithelial Cells 598 3674 3685 5747 3673 4609 1147 2335 3909 5925 367 5291 5290 4792 1869 5966 5970 3551 9618 1284 208 3655 3915 3914 7189 330 PMC5192802__F2 Roles of nucleus PRDX1 in the H2O2‐induced apoptosis 4485 5052 367 581 PMC5206486__F1 Domain structure of retinoic acid-inducible gene-I (RIG-I) 1283 3454 57506 7297 3716 7189 7187 3661 3665 PMC5206770__F10 Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice 5728 5163 7249 7248 5164 6009 253260 2475 6010 PMC5214729__F4 Proposed renoprotective mechanisms in diabetic nephropathy (DN) through adenosine monophosphate-activated protein kinase (AMPK) activation 92335 7249 4899 3156 2475 PMC5214768__F8 Interaction map representing CNV-altered genes enriched in GO classes and grouped on the basis of their main biological processes 2359 9342 4905 339983 3831 3975 596 7054 2896 8624 7473 54584 26047 3768 27445 1739 6928 23426 6929 1312 2894 65078 25 10395 5511 83849 60482 9378 1602 PMC5216724__F6 EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway 1956 3232 1958 PMC5216734__F8 Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1 6714 5901 27161 PMC5216781__F4 Overexpression of TELO2 decreases survival in human high-grade gliomas 207 472 1956 2475 545 9894 9675 8607 5290 PMC5216813__F6 Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer 1595 10858 1593 1582 51302 9420 PMC5217037__F7 miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NFKB and sustains NFKB activation by decreasing Cylindromatosis expression 7124 7186 1540 PMC5217378__F2 Ingenuity Pathway Analysis showing the top molecular Network in HSPC-derived myeloid cells collected at 1 week after exposure of mice to 0.1 Gy of 48Ti ions 51234 84316 84908 55187 10102 58527 83443 1657 56255 83440 57479 51031 7316 55628 4357 79792 79709 84681 54187 56889 55748 4718 26003 56926 51014 23420 PMC5217522__F1 Simplified schematic of Notch signaling.Notes: In mammalian cells, Notch receptors are synthesized in the endoplasmic reticulum (ER) 5045 2475 1499 100188776 3480 4609 PMC5223597__F8 Proposed model for the role INPP5E plays at cilia 6295 56623 23432 6608 79600 54903 27077 79583 80776 PMC5224989__F3 Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring 355 3630 3643 7249 6009 572 2475 1977 2885 PMC5225500__F1 Glutaminolysis in cancer cells 4609 2475 2744 2806 84706 PMC5225790__F13 VEGF/VEGFR signalling pathway in normal vs 4771 10371 8828 PMC5226550__F7 Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes 1445 5728 6714 PMC5226821__F13 m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks 3265 5914 4149 5900 1387 8772 867 3480 4609 7170 3912 581 9618 9915 7186 7422 1956 208 369 3728 1869 598 1399 25804 595 6635 6464 23450 10262 1026 3190 10523 5594 220988 1027 9343 7040 25 3192 23451 4088 11325 4193 6626 6631 1487 51729 1398 3303 207 5781 5970 4790 10915 7048 9128 6426 1021 11338 26121 22827 5894 PMC5237206__F2 Summary of three key signaling cascades that may mediate the link between inflammation and epileptogenesis 3146 7099 7048 4615 7189 7046 3661 PMC5237710__F2 PI3K/Akt/mTOR pathway involved in tumorigenesis and metastasis 5728 5163 2932 572 595 1977 PMC5239825__F4 NRF2 as a hub connecting proteotoxic-derived emergency signals to a protective transcriptional response 9817 5687 5717 5700 493869 5688 5718 5701 5689 5719 5702 8408 2729 5690 10213 5707 55102 5691 5682 5710 2730 84938 5711 5683 5692 9474 5713 5685 5693 10533 5686 5694 5714 51371 PMC5241026__F8 RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms 387 9545 23411 85415 PMC5241525__F1 Several signalling pathways can induce epithelial-mesenchymal transition in pancreatic cancer cells for example Notch, transforming growth factorB, Midkine, hypoxia-inducible factor-1A and tumor necrosis factorA 6935 3091 999 7040 PMC5270432__F4 rno-miRNA-mRNA network affecting VEGF signaling pathway based on the first global prediction.VEGF: Vascular endothelial growth factor 63928 5747 25759 842 7867 5296 4773 56848 5582 8399 10725 5600 5880 5894 5320 5579 9261 5595 26279 5532 8877 391013 100137049 4776 5594 4893 5322 4775 5829 1432 5534 5578 PMC5282884__F7 Illustration of interaction between NRIP2, RORB, and HBP1 6095 83714 6096 595 8313 6925 PMC5288241__F2 Prostate cancer and the unfolded protein response 22926 7186 83939 468 367 PMC5289991__F2 MYC-driven self-reinforcing loop in ESCs 4040 4041 324 2932 4613 4609 121536 4149 3976 79923 6657 1849 1844 PMC5292181__F5 Functional interaction network analysis by GeneMANIA of candidate mouse and human genes related to brain metastasis 2289 4171 51090 3356 121278 5427 284417 8914 2099 6387 29028 7349 7852 7293 5294 5962 5426 23331 7292 80145 4481 10165 7412 23657 374462 6543 1003 PMC5292326__F1 Functions of natural IgM in homeostasis maintenance and autoimmune diseases prevention; (A) sIgM enhances apoptotic cell clearance 4280 613 10113 921 PMC5295629__F1 Noncanonical NFKB signaling pathway 4050 7186 7187 5971 PMC5299128__F6 Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea 100653366 182 474 PMC5299404__F4 Mediterranean versus Red sea corals facing climate change, a transcriptome analysis 6714 4854 52 6932 387 7414 1956 6885 51701 PMC5301050__F1 Cancer Therapies in HIV Cure Research 920 941 942 940 3458 PMC5307356__F6 Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites 3399 3400 3397 3398 PMC5308720__F6 Expression/activation of A5B1 integrin is linked to the Beta-catenin signaling pathway to drive migration in glioma cells 1499 7431 6935 PMC5308742__F8 De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells 23475 10135 23411 2308 604 PMC5309296__F5 Phosphoproteomic analysis of SK-ChA-1 cells after ZPCL-PDT 10458 10580 3710 6654 10006 857 2316 4659 3320 5594 6197 2064 8826 5580 1432 4137 8986 3667 5829 8660 7791 10298 PMC5309878__F3 Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients 3553 3931 5091 254531 79888 54947 10162 10400 4018 PMC5310163__F7 Interaction of lactobacilli with transformed cells 27035 4025 4353 PMC5313049__F9 Genome evolution in the allotetraploid frog Xenopus laevis 1896 829 324 1499 7008 983 23513 4771 92359 286204 902 4485 9448 60485 26524 55233 92597 10413 8900 9133 85417 51286 894 7003 993 994 995 1027 1030 1031 6104 1032 5347 991 9212 11065 1350 9130 PMC5313500__F2 The proposed cellular functions of cellular NLRC5 7186 7189 3550 114548 84166 9097 3553 1499 4088 4087 57506 4089 4316 PMC5319840__F3 Tgfbr2 cKO CD34+ SCC cells upregulate genes implicated in invasive human cancers 7373 57554 8434 7431 729 9770 7454 2495 1325 4318 10875 2123 6696 6955 6423 22795 10763 633 2934 7145 1634 3507 2035 5552 1910 338 7175 6347 3937 3122 11054 2006 1356 51083 6503 7042 1675 920 721 629 PMC5321802__F2 Regulation of hepcidin expression in hepatocytes in response to iron status and requirements (left) or inflammation (right) 654 148738 3716 3717 6774 PMC5325695__F1 Emerging roles of p53 and other tumour-suppressor genes in immune regulation 3455 3454 7098 6773 6772 10379 51311 51284 29110 54106 3654 3663 51135 7189 3665 3661 338376 9636 581 355 PMC5328691__F1 Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance 22926 1998 7494 468 PMC5328691__F2 Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance 22926 1998 468 1263 1386 26229 78987 90411 PMC5328970__F3 Sema3A signaling in bone remodeling 10371 8829 5336 9855 387 1499 PMC5329687__F1 Nitric oxide dose effect on mitochondrial function and endoplasmic reticulum stress 4151 22926 6997 7019 PMC5334311__F1 The compensatory B‐cell proliferative signaling network mediated by insulin resistance 2932 7248 7249 894 PMC5334358__F1 Necrototic pathway 7186 7188 1540 79595 6280 3146 8772 8717 PMC5336163__F8 PAF-mediated endotoxin tolerance 9021 7099 3466 4615 3717 3716 3654 7189 55576 10454 PMC5338303__F2 Schemes of kinetic model used as a base for simulation of isotopologue distribution 4118 11113 5091 7084 PMC5339807__F4 Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling 7054 1191 3953 3099 4311 PMC5341000__F6 Role of DHT- and EST-regulated proteins in energy metabolism 790 8836 2744 7086 2821 64841 3074 11315 6648 3954 64976 8737 219 5660 8801 5162 4191 3030 1892 3032 PMC5344005__F1 Molecular functions of long non-coding RNAs (lncRNAs) at different stages of prostate cancer, from prostate adenocarcinoma (A) to ongoing castration resistance (B) to a castration-resistant state (C) 2078 2146 1164 102578074 5091 4088 2810 285463 367 57291 100188864 55384 7764 114004396 7054 4193 50652 158471 104472713 PMC5346727__F3 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method 1956 4137 5534 5871 4217 994 3265 5530 5296 9261 5747 8517 5604 3315 818 23118 1398 3727 817 1616 2353 4773 1649 3725 7018 9734 1540 1843 1977 7514 133 826 5478 PMC5346747__F7 Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a 89780 2262 324 7291 999 4313 PMC5347766__F9 PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway 472 6120 6135 4193 PMC5347792__F9 Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway 6469 6608 2735 PMC5347794__F9 Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway 2669 83939 2922 581 PMC5350147__F1 Akt/mTOR signaling schematic 4763 3667 5728 7249 7248 2475 1977 6194 PMC5352059__F4 Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers 3606 54472 4615 114609 3569 3929 929 4790 23118 23643 2353 8737 958 941 1513 6955 5777 1493 978 3932 868 2534 1739 917 3937 4690 5058 916 9402 27040 7410 387 2885 3558 3565 3586 50964 3458 1437 1019 84433 8915 4118 1610 29851 5290 PMC5352102__F2 Sirtuins in glucose and lipid metabolism 51548 23409 3416 PMC5352135__F8 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis 2638 1017 898 1855 1499 581 PMC5352210__F5 Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism 1956 468 467 PMC5355165__F1 Crosstalk between microRNAs and the Wnt/Beta-catenin signaling pathway in cancer 442917 693188 693198 100302114 693195 664613 1499 100302276 324 100302156 407009 693128 864 607 693197 595 3481 PMC5356795__F6 Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network 5885 4118 717 5111 1017 23632 PMC5357762__F1 Canonical and non-canonical Wnt signaling 6047 84133 1499 5218 324 23002 387 55294 3725 PMC5358800__F1 Myelodysplastic syndromes: updates and nuances 9055 54790 23451 861 1788 6427 171023 10735 2146 3418 3417 8233 54880 PMC5359376__F5 Enrichment analysis for pathway map ontologies revealed significant biological processes associated with the most promising targets commonly deregulated in mouse and human ALS 8178 2246 1950 PMC5362072__F3 Cell-intrinsic effect of STING activation in tumor cellsThe functionality of the STING signaling pathway can be altered in tumors.A) Oncolytic viruses like HPV or adenoviruses drive E7 or E1A oncoprotein expression 115004 8480 80198 PMC5362340__F1 Kinase signaling and targeted therapy for primary myelofibrosis 4352 3717 5058 22974 983 79866 811 6774 6790 387 PMC5362524__F8 Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NFKB in vitro 1950 1956 581 PMC5362547__F2a Hippo signaling pathway provides novel anti-cancer drug targets 4485 6010 60485 9113 26524 55233 92597 4771 154796 5784 PMC5362636__F2 Possible interplay between insulin-like growth factor (IGF)-1 and vascular endothelial growth factor (VEGF) receptor signaling pathways 3479 1499 860 650 947 4322 51199 PMC5364554__F9 Acceleration of bone regeneration by activating Wnt/Beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis 10023 324 2932 1499 860 4040 4041 PMC5372268__F4 KEGG pathway hsa05200 “Pathways in cancer” 1636 1399 5914 8564 5073 PMC5372601__F1 RAS/RAF/MEK aberrant signaling and mechanisms of resistance to inhibition in melanoma 1956 2885 5728 2475 PMC5372717__F4 Localization of Moco biosynthesis, FeS cluster biosynthesis and tRNA thiolation in humans 2242 4553 9054 27304 81605 90353 PMC5372728__F2 Effect of chronic alcohol intake on mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in white adipose tissue from mice 7249 7248 1977 29904 1975 PMC5375109__F1 miR-33 regulation of adaptive fibrotic response in cardiac remodeling 29102 335 19 1019 595 PMC5377794__F6 Diagrams demonstrating the processing of Okazaki fragments 1763 2237 9156 5426 PMC5378285__F8 A hypothetical mechanism for the anti‐tumor effects of verteporfin in pancreatic ductal adenocarcinoma (PDAC) cells 898 595 4313 581 1003 PMC5378934__F8 Schematic model of TBL1XR1-promoting ERK activation and gastric cancer progression 999 1000 9839 79718 1499 4316 PMC5379509__F8 Novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks 1021 145873 7314 7316 2116 892 113878 58158 79576 23013 7408 7089 23090 9978 22938 3937 83737 55072 27040 6907 4690 387357 8454 26523 5970 57534 8631 9146 8915 23462 9402 55759 7454 23385 26191 10892 55851 4760 56983 PMC5381329__F1 Homocysteine metabolic pathway 4548 4524 875 1491 PMC5381815__F2 TAM Receptor Tyrosine Kinases as Emerging Targets of Innate Immune Checkpoint Blockade for Cancer Therapy 8205 6772 8651 9021 PMC5382875__F1 Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer 960 23411 1021 4851 PMC5382886__F1 TLR4, MyD88 and TRAF6 down-regulation following glutamine administration in LPS-stimulated peripheral blood leukocytes of pancreatic cancer patients 929 114609 4615 7189 4703 PMC5389546__F3 let-7c is predicted to target the RAS signaling pathway and miR-98 4199 4763 6010 572 27040 5894 64434 4781 PMC5390360__F4 Interaction between AMPK and AKT on the phosphorylation: Growth factor activates TKR and promotes the activation of AKT via IRS1/PI3K/PDK1 signaling 5728 3667 5163 PMC5390895__F7 Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice 5597 83595 1832 613 23541 92610 25828 200186 3611 83667 53834 8857 5126 339403 59350 222545 108 1301 2520 5997 4606 5587 6134 6258 5465 27236 6152 PMC5391045__F2 Heart Failure in Pediatric Patients with Congenital Heart Disease 7273 1674 8557 5350 4633 88 1824 1832 5318 1829 4000 7139 3728 7414 3265 55636 3845 7026 5605 4838 2719 PMC5393956__F2 mTORC1 and mTORC2 in cancer and the tumor microenvironment 5728 5163 7248 7249 6009 PMC5395355__F2 Phosphopeptides from the MOE and FOE phosphoproteomes are represented in some distinct signaling pathways, including Rho signaling for MOE (A), GABA signaling for FOE (B) and amyloid processing for FOE (C) 6010 5962 4478 7430 10243 11337 4905 351 1356 PMC5397035__F12 Lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement 6850 695 5058 PMC5397843__F1 Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors 1028 1027 6135 1029 595 1017 5111 1026 1021 896 1387 7316 1019 2033 2034 7157 4194 7341 405 6502 8453 4193 7428 PMC5398881__F6 Scheme showing hyperglycemia-induced VEGF expression regulated by PRR, RAC1, and miRNA signaling 5879 4015 4092 5728 10252 3091 PMC5400654__F1 Involvement of inflammation and its related microRNAs in hepatocellular carcinoma 4089 4087 4088 57154 1499 387 3516 6722 1386 9839 6935 999 1000 7448 PMC5402004__F10 Schematic signal transduction network representing the observed changes in protein and lipid metabolism in eWAT during sepsis-recovery 7249 7350 7248 6009 8408 1977 114548 83939 9474 9140 468 PMC5402913__F1 Profile of romosozumab and its potential in the management of osteoporosis 4040 4041 1499 2932 7008 PMC5406704__F1 The phosphatidylinositol-3-kinase (PI3K) pathway 7852 5163 5728 581 2475 PMC5407490__F1 AhR signaling inhibits crosstalk with ERA in breast cancer cells and AhR agonists and antagonists are tumor-specific anticancer agents (24, 25) 367 196 405 PMC5408670__F1 Tumor necrosis factorA (TNF)/TNF receptor (TNFR)-mediated cell signaling 920 7124 7186 8772 8717 PMC5409508__F2 Material Cues as Potent Regulators of Epigenetics and Stem Cell Function 2475 8168 6010 PMC5412393__F4 Potential contribution of protein disulfide isomerase (PDI) and various environmental factors in regulation of the TF-fVIIa complex on the surface of epithelial ovarian cancer (EOC) cells 7035 7018 768 PMC5417569__F5 Transcriptome analysis of muskrat scented glands degeneration mechanism 90550 5481 5350 3371 857 858 859 613 952 PMC5418193__F1 Insulin/insulin growth factor signaling pathway and its activation by reactive oxygen species (ROS) 5728 7248 7249 PMC5420131__F2 Therapeutic targets in Wnt/Beta-catenin pathway and developmental therapeutics 1499 64840 7008 PMC5421758__F2 Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models 9425 4067 23588 6844 11260 9788 23039 23326 57862 23760 5211 3169 5316 9921 5576 4640 7726 27434 65125 5604 4179 9972 8945 84720 7421 6772 11338 22884 11337 10273 5764 374655 667 1936 4851 4794 5756 79083 1155 602 8473 10155 1869 11273 8837 6305 6294 10959 54857 4878 4710 4352 51226 1211 6637 4841 7534 580 6955 3064 10025 5589 3183 412 1994 10278 1616 7145 10818 10914 2778 7965 5515 5594 10296 10724 79811 2033 55825 4323 6010 1950 PMC5422801__F6 Hippo–YAP pathway mediates physiological resistance to gemcitabine 978 4485 1633 9113 26524 51421 PMC5426484__F3 Network fabricated in CellDesigner 627 1610 107966124 23373 5979 4942 PMC5428427__F8 Proposed model for the suppression of inflammatory cytokine production by globular adiponectin in LPS-stimulated macrophages 79602 51094 9817 7189 3603 PMC5428537__F1 Meta Core pathway analysis indicated that cardiac hypertrophy signaling was significantly associated with sesamin-treated samples (P=1.148E-10) 2548 4286 7222 324 2626 465 4208 9464 9421 PMC5429641__F7 Neuroprotective action of MMP-9 in preventing ABeta-mediated impairment of the insulin survival pathway 627 3667 2932 PMC5429979__F2 Glutamine/glutamate utilization in proliferating cells 8140 6520 29968 2875 51660 25874 6576 5132 2806 2744 84706 587 2746 2747 2752 4190 4199 2805 10165 PMC5430417__F6 Mechanisms involved in the antagonist effect of sinapic acid against UVA-induced attenuation of stemness and differentiation properties of stem cells 1050 4282 10365 PMC5433957__F2 Mechanisms of GPC3 in acute lung injury 2719 1499 1386 PMC5436210__F2 Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma 100422903 55102 5813 361 9935 4087 4088 7157 92140 7465 835 10912 84433 6654 6741 1839 10891 31 861 2194 6194 6319 23411 3702 8431 3418 58508 PMC5436295__F3 MAPK signaling pathway 26136 4803 627 1956 1950 2002 5894 6722 4342 4763 9118 7124 7186 355 1616 4149 4208 23118 7189 51295 51701 PMC5437112__F1 Illustration of autocrine and paracrine signaling pathways in colorectal cancer 6469 8313 6608 1499 80351 324 2146 5948 4040 3845 673 PMC5437952__F2 Metabolic changes in plasmacytoid dendritic cells (PDC) providing energy and affecting their innate immune functions: glycolysis versus fatty acid oxidation coupled with OXPHOS 5132 51284 3091 3665 3569 7124 54106 5465 3454 3455 PMC5445595__F3 T cell gene expression analyses of T cells from sargramostim-treated or placebo-treated PD patients 6097 9235 3562 356 355 8320 10261 2615 5468 3569 3394 11009 3662 7157 64065 94241 10911 PMC5446300__F4 T-Lymphocyte Homing: An Underappreciated yet Critical Hurdle for Successful Cancer Immunotherapy 940 2919 3577 960 3579 7412 2833 7124 3458 PMC5452197__F3 Schematic representation of the intestinal inflammatory pathway expression altered by Hydryeast supplementation (DHY8) in dextran sodium sulfate (DSS)-induced colitis 3006 6775 3458 64127 PMC5454408__F2 HBV modulation of innate immune sensors 5132 9447 54106 7097 7098 7096 10333 920 114609 4615 23586 57506 85451 2146 PMC5454932__F2 Intracellular GH signaling 3717 2475 6714 PMC5459509__F12 Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations 2239 324 6010 PMC5460571__F4 Representation of the molecular interaction pathway analysis of the associated and causal genes linked to aneuploidy 4552 10592 1826 5395 7012 351 PMC5462754__F6 Ingenuity Pathway Analysis showing a network biology system for the interaction between both the miRNAs and the metabolites identified from the metabonomic analysis 3643 2890 6809 2891 155 6854 351 153 146 23365 3156 1390 5925 867 PMC5462960__F7 Location of BHP biosynthetic genes and gene clusters in the genomes of SD1, SD3, and SD4 Acidobacteria and a number of selected environmental genomes as determined by BLAST protein searches 3249 126669 4597 4598 3156 PMC5466396__F9 Crosstalk of hypoxia-induced endothelial-mesenchymal transition (EndMT) signaling pathways 4851 864 4087 4088 4089 100188776 PMC5467707__F3 Pathway of Huntington’s disease enriched in target DEGs of DEmiRNAs of AD 3064 4478 25942 5978 627 3092 140805 6908 6874 836 25886 6648 7350 581 317 PMC5467707__F4 Pathway of AD enriched in target DEGs of DEmiRNAs of AD 351 10313 57142 23385 3416 4023 348 572 842 836 8772 637 317 6622 100506742 7124 2932 840 PMC5467823__F6 Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer 9718 11173 5350 8748 597 53616 56300 11085 56999 4920 11086 8837 8749 9509 8747 11174 118856 4185 64167 PMC5472377__F6 Pathway alterations diagram integrating gene mutations and copy number alterations to identify pathways altered in UC- and CD-associated CAC 2263 1956 2260 2064 5728 5266 2475 4763 3845 673 7248 7249 4609 1029 324 1019 1021 595 898 55294 1499 4089 5925 472 PMC5474285__F5 Network pathway: pathway enrichment analysis was performed 7097 7099 64127 6774 324 PMC5480600__F3 Tumor-Associated Macrophages as Treatment Targets in Oncology 961 55423 8205 958 6352 729230 1234 4513 4512 717 PMC548501__F4 Taxotere and Furtulon on cell cycle, apoptosis, and other pathway related gene expression analyzed and visualized by GenMAPP software integrated with cDNA microarray data 4616 596 1647 1999 1025 1019 1017 1021 6723 672 580 5608 60436 996 5111 7008 PMC5489427__F2 Purinergic signaling in microglia in the pathogenesis of neuropathic pain 6347 729230 4067 3663 1977 4193 3394 PMC5489563__F1 Action of thioester-containing proteins (TEPs) in mammals and mosquitoes 716 727 718 7448 7011 PMC5489807__F3 Levels of crosstalk between the HIF and the NFKB pathways 55611 331 5970 22992 PMC5492892__F1 Molecular networks between genes involved in NB development by the data mining IPA software 9313 11200 546 7015 3845 672 79728 4613 596 238 PMC5495879__F3 Overlap of the present results with Greengard’s neurotransmission integration scheme 1813 63826 2894 488 2890 3710 85450 4985 10590 2550 9568 2913 83698 4900 9628 4925 25858 2555 2788 1020 7223 140803 5520 5523 107 5142 5152 491 5521 55012 4842 51070 1135 1136 1740 1143 348980 3745 26251 27012 8911 783 3782 3760 PMC5497827__F1 Summary of the canonical Th2 pathway and “new spins” on the pathways that lead to allergic inflammation 85480 90865 196 3597 8651 8660 3565 64806 9021 10273 163486 PMC5499156__F1 Proteins that interact directly or indirectly with mGlu1/5 receptors and mediate receptor signalling 160622 5266 2475 PMC5499698__F1 mTOR-signaling pathway: mTORC1 and mTORC2 complexes and the key signaling nodes that regulate mTORC1 and mTORC2 2885 5728 5163 7249 7248 6009 2475 64798 253260 64223 9675 PMC5499698__F3 Alterations in mTOR signaling pathway on spermatogenesis 5728 7249 7248 6009 6194 PMC5499780__F1 Action of lenvatinib and everolimus.Notes: Lenvatinib inhibits RTKs on endothelial cell and cancer cell 5163 2475 7428 PMC5501176__F2 Roles of mTOR signaling pathway in cancer in type 2 diabetes 5170 7249 7248 3551 23411 6009 2194 6720 3091 1978 7422 PMC5505746__F1 Proposed potential mechanism of MDSC-mediated T cell suppression through LILRB1/2 and HLA-G interactions 3135 10288 10859 6774 6778 383 PMC5510801__F1 Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model 22943 6422 324 1499 PMC5512418__F7 The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity 9113 26524 4615 PMC5514447__F2 Low-dose triptolide and aspirin suppress NFKB survival pathways 5351 3340 90952 187 5924 4320 10203 4237 10266 2200 2012 1948 1003 2004 196 3248 389 1602 4223 654 22918 4254 23705 94 6659 54567 7102 1636 3976 3909 9590 10631 4881 952 23462 54756 100506658 3914 8817 7010 5272 3384 10512 7434 3918 1803 163351 83597 3091 362 58494 3082 948 4128 3815 3485 4129 8743 3486 7447 134265 3552 2690 3707 8870 2150 857 10395 2294 133 29923 6910 3673 2022 1910 1030 2321 3553 6667 PMC5514546__F2 KEAP1-NRF2 Signaling and Autophagy in Protection against Oxidative and Reductive Proteotoxicity 64422 10533 83734 3146 PMC5514916__F8 NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway 4089 4193 90 PMC551522__F1 The Wnt signal transduction cascade 23002 324 6010 1499 PMC5516940__F3a Proteomics analyses of prostate cancer cells reveals cellular pathways associated with androgen resistance 2475 10682 7249 5879 613 6850 4609 930 595 5934 5728 572 5266 6256 4193 PMC5516940__F5 Downregulation of several proteins in the oxidative phosphorylation pathway identified in the global proteomic data for LNCaP-95 androgen resistant prostate cancer cells 4537 4538 126328 4701 4716 4536 4541 6389 6390 6391 6392 4519 4513 4514 10063 PMC5518133__F2 Regulatory mechanisms of WBP2 in breast cancer 1956 23558 1499 595 PMC5518632__F3 NLRC5/CITA: a key player in cancer immune surveillance 84166 6890 3105 PMC5519339__F2 CREB-induced IL-10 production is regulated by IFNG 1843 2932 6667 PMC5522997__F9 Representative gene networks that were significantly regulated (P < 0.05 with the Fisher's exact test) in response to cocaine in WT compared to SERT Met172 mice 25849 7881 3741 55188 3736 51764 4741 1808 111 10681 4747 8786 5204 4750 120892 8787 79739 1677 11170 10602 6170 6167 6334 6262 6538 6323 7804 6418 8506 7143 5787 19 7450 11122 53353 5793 8471 5789 51655 10678 23049 25907 80274 PMC5524810__F1 Angiotensin II signaling pathway underlying vascular aging 1636 4313 4318 PMC5525000__F1 Schematic representation of sulfides (H2S) synthesis and oxidation pathways 847 875 58472 2937 7263 PMC5525062__F2 Pathological pain and the neuroimmune interface 729230 3553 1236 1378 7124 627 3383 7097 7099 4615 4318 3554 114548 156 3146 4067 2833 3084 6347 6366 4313 PMC5528145__F2 Mechanistic association of insulin signaling with mitochondrial function in normal and diabetic brain 627 23411 2932 2931 PMC5529431__F5 Representation of the putative signaling pathways involved in B-cell clonogenicity induced by interaction of S75X/p17R76G with p17R(s) 7534 1017 842 5058 11200 983 5076 PMC5531511__F3 Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort 759 51701 6502 4193 664 3630 3643 472 4351 1017 10365 PMC5534294__F5 Signaling pathways underlying podocyte injury in DN 6010 27201 6093 1499 PMC5535015__F2 Up-regulation of BIRC3 transcription by NPD1-dependent c-REL expression 7186 7187 8717 330 29110 PMC5536301__F7 Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis 2821 2729 9563 2937 25796 5226 PMC5537069__F6 Schematic representation showing downregulation of miR‐205 by ErbB2 signaling via Ras/Raf/MEK/ERK pathway 2064 642587 406988 PMC5541270__F8 Proposed mechanistic scheme of MUC13 regulating NFKB activation, related to , , and 56667 8717 7189 472 142 PMC5542021__F1 Signaling pathways for selected transcripts that regulate dendritic spine density 396 998 10602 23580 5058 1000 387 PMC5542024__F9 Graphical Summary 1445 9138 847 387 PMC5542379__F1 miR-133b/206 Associates with Various Genes Mediating NSCLC Cell Migration and InvasionmiR-206 promoted lung cancer cell apoptosis by targeting c-Met and Bcl2, as well as governed EGFR, MET, and its downstream phosphorylation of ERK1/2 and AKT 596 1956 599 4170 6662 154075 6624 999 PMC5542379__F2 miR-206/133b Cluster: A Weapon against Lung Cancer? 2820 7086 154075 2539 28951 596 PMC5543040__F1 Gonadotropin-releasing hormone (GnRH) receptor signal transduction in human cancers 1950 8205 1956 2798 6714 581 595 3727 672 PMC5543131__F5 Differentially active pathways across pan-urologic genomic subtypes 25796 2539 3099 3098 3101 727 729 5226 718 730 735 717 2821 6120 22934 5211 6888 5214 2194 5213 226 7086 7167 2597 5230 5232 55276 5236 2026 29968 2023 2027 5723 6470 10993 6472 113675 3948 197257 3939 6576 3945 1738 1737 5160 5162 5132 4190 50 3418 54704 4199 4191 57546 2271 4967 5163 5164 6390 6391 6392 5165 5166 3091 595 9817 8452 4771 23286 60485 9113 26524 PMC5546324__F6 AKT/PKB Signaling: Navigating the Network 3630 3479 1950 2549 9846 3667 8660 23216 9882 7249 6009 1977 1956 3480 PMC5548020__F2 Insulin signaling pathway 1398 1358 355 65057 3643 5163 5164 3630 7249 6009 572 2475 PMC5548104__F3 The PI3K-AKT-mTOR signaling pathway 2261 5296 5290 5728 4763 2475 572 4609 5170 6794 2146 1978 7248 6009 1977 7249 4193 1026 1027 51230 595 7428 6194 PMC5548104__F4 Reelin-LIS1-tubulins pathway 54820 81565 6844 3796 7283 1641 51807 347733 203068 7846 284403 PMC5548997__F7 Involvement of BPA, BPS or BPF in the proliferation, EMT, and migration of MCF-7 CV cells via ER-dependent pathway 595 898 1000 999 PMC5549971__F7 Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses 672 9612 9611 23411 25942 4204 8202 2033 3066 8819 8850 3065 8648 2648 5928 5931 10284 3838 PMC5550428__F6 Regulation of ΔF508 CFTR stability by inhibitors to the PI3K/Akt/mTOR pathway 1080 3297 9531 8678 PMC5555103__F1 Fatty liver diseases are initiated by aberrant hepatic lipid metabolism, and sirtuin 1 (SIRT1) activation plays beneficial effect against the process through inhibiting de novo lipogenesis and increasing fatty acid Beta-oxidation 23411 355 79071 5465 7038 PMC5557591__F5 Effect of masticatory stimulation on the quantity and quality of saliva and the salivary metabolomic profile 2593 2628 384 162417 65057 4191 5009 PMC5559174__F8 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 2475 9776 8678 596 9474 10533 3920 55054 9140 3916 55014 64422 8878 4077 23001 PMC5559174__F14 Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome 3569 3479 23411 6009 2475 875 1998 6010 9575 PMC5559791__F3 Interactions of two transcription factors (PPARG and PPARD) and their direct target genes that control lipid metabolism in abdominal fat of juvenile HG and LG chickens 5340 27329 6581 376497 7057 9114 5467 7058 2180 5468 5166 55074 165 596 335 1050 7436 7431 203068 84649 8723 51380 2167 2194 6920 51141 3921 4023 55022 6515 9172 5105 11343 4257 51154 10397 PMC5559791__F4 This adipogenic gene network is centered on the up-regulated transcription factor CEBPA and interactions with several other transcription regulators (a) 3837 3838 3839 344901 3984 64798 80221 9442 55294 51621 3399 10365 1874 1050 51154 2180 948 596 2167 445 1277 1278 213 4628 84649 2182 4023 2194 2633 8660 3290 3106 688 PMC5560156__F1 Schematic overview of the molecular network involved in VSV oncoselectivity 3949 5728 29110 3661 2475 PMC5562070__F1 TGFB signaling induced apoptosis is modulated by the UPR cascade 4087 4088 83939 7494 4089 468 PMC5567228__F6 Wnt/FZD4 signaling pathways through the interaction of miR-204 with FZD4-miR-SNP (rs713065) variant in NSCLC cells 7042 8829 50848 5879 2335 7040 4609 1601 3569 1856 4040 595 324 2487 801 3251 2114 11197 6714 10454 1499 4193 51701 960 6925 920 22943 6422 PMC5568615__F2 COX-2/PGE2pathway in colitis-associated CRC 4512 5226 2919 PMC5568783__F1 IRE1A arm of the unfolded protein response 85451 10628 7494 637 114548 581 3603 PMC5569945__F2 Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia 3667 5163 5728 7249 51256 7248 6009 652968 375 6194 27250 1975 29904 PMC5571522__F7 Diagram of CPT inhibiting IGF‐1/AKT/mTOR pathway via suppressing the ERA in breast cancer 3479 3480 3667 5728 PMC5573165__F1 The polyamine-hypusine pathway 4609 1984 6723 262 1725 6611 6608 83475 PMC5578103__F3 Schematic diagram illustrating the mechanisms of how the estrogen receptor (ER) coordinates with the epidermal growth factor receptor (EGFR) to affect the cell growth in the lung adenocarcinoma 1950 6714 2475 1956 PMC5578430__F1 Innate immune escape by Dengue and West Nile viruses 1283 115004 7706 57506 29110 3661 3663 3665 PMC5581122__F7 Hypertriglyceridemia in female rats during pregnancy induces obesity in male offspring via altering hypothalamic leptin signaling 4160 181 5443 4922 23237 PMC5584302__F2 PD1 signal transduction pathways in T cells 940 5728 7535 1017 4088 213 83737 PMC5584741__F1 Regulation of autophagy signaling pathway 83734 10533 2475 9140 9776 9474 22863 7405 55626 64601 64422 PMC5585663__F1 The Nrf2/Keap1/ARE pathway in type II diabetes mellitus 1728 6647 2939 9817 PMC5585869__F5 BCR–ABL pathway drives signaling in H929 cells and phosphorylation is inhibited by imatinib 6464 9846 613 4863 PMC5587179__F2 Processing and digestion of engulfed apoptotic cells utilizes LC3-associated phagocytosis and promotes an anti-inflammatory response 7405 10533 9140 19 PMC5587385__F7 InterferonA Negatively Regulates the Expression of Endothelial Nitric Oxide Synthase and Nitric Oxide Production: Implications for SLE 7412 3383 3667 PMC5591063__F4 Changes in Adipose Tissue During Weight Gain 6347 6352 920 PMC5591886__F2 A crosstalk between endoplasmic reticulum (ER) stress and p38 mitogen-activated protein kinase (p38 MAPK) pathway in the context of pemphigus 22926 5045 100188857 PMC5592089__F1 PI3K/AKT/mTOR pathway and interaction with PTEN and TSC1/TSC2 1956 5728 2475 2885 3667 5163 572 7248 7270 6009 PMC5594543__F4 Influence of PM10 exposure on coagulation 2161 5340 2147 5091 1361 PMC5595129__F1 An overview of roles of miRNAs as a regulator of DDR in response to radiation in cancers 6741 693122 472 545 672 3014 5888 675 PMC5595361__F4 Interrelationships between programmed cell death 4615 7189 8772 8717 3661 2475 PMC5596881__F2 Therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools 1026 1874 1437 3799 378938 4174 57448 1958 83879 6652 10725 6241 2940 4288 5422 51322 3932 916 940 920 5896 7454 4775 11184 50852 4615 4199 9804 5226 11010 9982 1982 26580 57560 3073 3569 7076 7316 8544 316 874 1528 2729 23657 2512 3162 5052 140809 3320 3312 7296 374 9518 929 6372 2921 3557 5591 5885 56978 2969 183 55125 387758 284 120114 167681 PMC5599481__F4 Overview of arachidonic acid cascade associated with inflammatory pain response 4512 4049 5226 5228 4050 PMC5599995__F6 Proposed model by which mesenchymal stromal cell (MSC) derived soluble PD‐1 ligands modulate the activation status and effector function of CD4+ T cells 940 920 5728 PMC5601173__F3 SOCS molecules: the growing players in macrophage polarization and function 3717 6775 6774 6778 7297 3566 3587 3718 PMC5601349__F1 Alternative pathways of gluconate-6P formation by dissimilation of glucose in Burkholderia 4190 2444 1896 PMC5603903__F8 Schematic diagram summarizing factors influencing the signaling efficacy of the TLR2/1-VDR pathway in response to TLR2/1 elicitation 5066 1445 1628 5741 114609 7421 PMC5604081__F1 Regulation of intrinsic cancer metabolism by obesity-associated growth factors 3479 3480 2475 3099 4609 2539 5209 2936 3939 1431 47 355 PMC5609982__F10 Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death 995 891 581 PMC5612418__F3 Neuroprotective actions of perinatal choline nutrition 1103 55349 4548 4524 4143 191 PMC5622154__F2 Differentially expressed genes upon congenital neonatal human cytomegalovirus (HCMV) infection form distinct subnetworks 10289 10900 5886 23770 2987 91300 2035 25793 80700 598 2766 55544 997 51094 25893 7145 6521 3029 8818 9921 27090 23762 2038 4635 115361 8991 3437 527 2633 51327 759 212 115362 2907 91543 2994 6772 4818 2999 2996 5551 PMC5624830__F1 NOD1 and NOD2: beyond peptidoglycan sensing 5879 64127 10392 387 PMC5626595__F1 ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES 7706 9958 115004 3455 3454 57506 3716 9636 4599 1386 10379 3661 PMC5627649__F4 Signaling and gene regulatory networks in mammalian lens development 1409 1414 5080 5629 3299 PMC5627649__F5 Signaling and gene regulatory networks in mammalian lens development 51232 4041 4040 4771 182 1000 3611 PMC5629024__F3 Gene networks with the genes in core from GSEA analysis 60468 7106 5324 84101 114112 9645 2826 639 7253 3875 1499 8809 84327 8204 1602 351 5605 10218 729230 7153 22822 59277 214 79026 PMC5629826__F1 Dopaminergic pathway genes and serotonergic pathway genes 7054 1644 3351 4128 1312 3356 1815 1813 1814 1816 1812 PMC5630287__F6 Beta-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP)ribosylation 349565 23057 10664 10135 PMC5630446__F2 Bladder cancer stem cells: clonal origin and therapeutic perspectives 6469 2932 51684 2736 2737 2735 PMC5633884__F7 Elevated expression of Par3 promotes PCa metastasis via Hippo pathway inactivation 122786 4312 6935 7291 PMC5636945__F1 Linear modules for conversion of glucose 2896 3250 7273 PMC5638334__F10 De novo transcriptome sequencing of Isaria cateniannulata and comparative analysis of gene expression in response to heat and cold stresses 11311 7792 51652 387 382 8027 PMC5642448__F1 Insulin signalling pathway 126669 2885 5728 PMC5644649__F3 Signaling model of Nef-mediated (A) apoptosis/anti-apoptosis, (B) down-regulation of expression of MHC class I molecules, and (C) down-regulation of the expression of CD4 molecules 375 6850 572 3932 998 382 55690 920 PMC5645256__F2 Association between expression of cell cycle proteins in NETs according to pathway 1026 1029 1027 898 1021 1019 595 1017 PMC5645510__F2 KEGG pathway “FOXO signaling pathway” is regulated by let-7 miRNA 4089 759 51701 6502 4193 664 5728 3630 3643 472 1017 3569 3586 10365 1950 PMC5650102__F2 T Cell Signaling and Gene Regulation Defects in Systemic Lupus Erythematosus (SLE) 114836 960 29851 7097 2475 1786 3662 6774 604 PMC5650494__F3 Immune mediators in the brain and peripheral tissues in autism spectrum disorder 5728 7248 7249 1977 6009 57575 PMC5652852__F1 Chromosomal instability and acquired drug resistance in multiple myeloma 991 999 324 2068 2067 898 PMC5653458__F1 Emerging roles for the lysosome in lipid metabolism 3949 38 4864 3988 10577 PMC5654500__F3 Lost in translocation: The function of the 18 kD translocator protein 706 57120 5105 211 PMC5657500__F1 Death receptor signaling in the heart: cell survival, apoptosis, and necroptosis 8717 7186 8772 842 197259 836 581 PMC5659885__F2 Stretch-induced actomyosin contraction in epithelial tubes: mechanotransduction pathways for tubular homeostasis 7408 387 6714 PMC5661630__F3 ZIP-mediated signaling pathways promote cell proliferation and metastasis in luminal and tamoxifen-resistant breast cancer cells 2932 999 6774 1950 1956 6714 PMC5665169__F3 RNA editing-dependent epitranscriptome diversity in cancer stem cells 124540 3205 4609 22807 26986 1981 8650 10099 PMC5668000__F6 Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer 5587 4149 4609 367 1499 PMC5669809__F3 Mixed Chimerism-Based Transplant Tolerance 324 958 941 942 940 2475 3718 5728 581 PMC5680911__F7 Simplified graphical scheme representing the effect of Caspase-8 depletion on hepatic apoptosis and steatosis in the pathogenesis of ALD 1571 841 7038 842 836 PMC5683102__F3 Loss of NLRX1 exacerbates neural tissue damage and NFKB Signaling following brain injury 7124 958 4615 7186 8772 8717 3654 51135 10392 7189 841 29775 8915 5966 5971 3659 3458 330 183 3586 6772 6347 PMC5684302__F2 Interrelationships between growth factor, nutrient availability and energy sensing pathways in metabolic regulation in health 3480 3479 2475 PMC5684415__F1 Highest confidence network of genes significantly dysregulated by miR-7 64151 24137 9493 94025 991 6790 9928 55143 2305 891 9319 3832 9133 57552 64919 6241 83593 4091 6518 PMC5684649__F1 Proposed salinity tolerance mechanism in Cicer arietinum L 10486 79800 6655 6654 PMC5687887__F1 Summary of pathways and signals discussed in this review that induce NK cell activation and/or NKG2D ligand expression in tumor cells and in virus-infected cells 8841 545 472 468 3661 115004 PMC5694456__F9 Schematic illustration revealing the anti-inflammatory effects of gApN on microglia 51094 7124 3553 PMC5700130__F4 Representative terpenoid biosynthesis pathway with cognate heat maps for transcript levels of genes from transcriptome data with substrates and products, colored arrows connect substrates to their corresponding products 3422 91734 3652 9453 PMC5700507__F2 Immediate immune responses of pulmonary resident cells to RSV infection in neonates 2919 90865 85480 6761 942 5132 PMC5701012__F7 PD-L1 upregulation in response to DNA double-strand breaks 9156 6774 472 6772 3659 545 675 5888 PMC5702541__F3 MSCs secretome and tumor stemness 650 652 93986 9242 3579 6935 6275 6657 2919 4318 6372 6774 3717 7852 1950 PMC5706812__F10 Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway 652995 10000 2475 1977 PMC5710702__F1 Three interconnected intracellular signaling pathways in pancreatic B cells 2695 7432 885 PMC5711814__F2 Non-canonical regulation of HIF-1A stability 718 6010 7345 26118 10399 4193 5728 2475 PMC5712622__F3 Akt/mTOR pathway represents a major axis of phosphorylation signal transduction in response to phagocytosis 6009 2475 57521 84335 7248 7249 1975 6194 2885 3667 5163 595 1499 5728 5105 253260 572 10161 10681 598 596 1977 4609 PMC5715491__F7 Pathways involved in apoptotic and EMT effect by genistein in HT-29 cells 999 1000 581 6935 7291 PMC5715672__F3 Pathway of catecholamine biosynthesis 7054 1621 5409 PMC5723694__F3 TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion 7124 3458 8651 8554 2922 3434 10379 3659 3430 6955 PMC5727313__F1 The B‐catenin‐dependent Wnt signalling cascade in the ON‐state 4041 4040 1499 324 54623 5105 PMC5731828__F1 An emerging role for the ribosome as a nexus for post-translational modifications 6194 6204 6949 23521 6209 6187 6188 6224 PMC5731897__F3 Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study 10516 1843 2274 3037 1545 1902 5594 133 4314 10135 4846 6774 5054 5329 5743 3624 958 673 367 8862 7531 7508 5728 1500 5583 3084 4149 PMC5733345__F1 Principal pathways of cell death 637 572 3553 8772 8737 79608 11035 197259 581 PMC5733538__F6 The positive feedback regulation between transglutaminase 2 (TGM2) and TLR4 signaling in hepatic stellate cells (HSCs) activation and liver fibrosis 7052 7099 929 4615 3661 3654 3553 3569 3439 6352 3627 PMC5735681__F1 Different proteins on the Wnt signaling pathway 7476 324 1499 89780 2932 PMC5735681__F3 Interaction between the Wnt and the Notch signaling pathways 89780 3280 388585 PMC5739856__F1 Neutrophils promote tumour growth through direct and indirect mechanisms 383 920 6361 PMC5743003__F1 Signaling pathways involved in the pathogenesis of MPNs and secondary AML 7173 811 4352 2056 2057 3717 5163 2885 4193 2475 7157 54790 1788 171023 2146 PMC5746035__F1 The glycolysis and pentose phosphate pathways (PPP) are tightly connected 2539 2147 57103 2203 95 PMC5746035__F3 Oncogenic regulation of glucose flux into PPP 2539 2147 57103 1021 PMC5746087__F7 miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis 2885 3611 5728 5163 11140 7248 572 4193 7249 6009 1499 79923 595 2475 1977 PMC5746105__F17 Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury 2628 384 1525 790 1491 29958 175 1806 5795 9308 7124 6364 50507 51181 11200 4792 629 50632 1540 3815 1508 2353 5589 5696 7450 2254 9470 387 8531 55840 7037 1191 7263 2182 10950 7171 2194 9365 2590 8029 132158 79634 5329 65266 1950 53947 2669 PMC5746415__F1 Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade 50943 6352 6354 3576 8205 1499 5728 3717 567 3902 151888 PMC5748601__F1 TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis 3929 7099 114609 4615 51135 3656 3654 7189 7187 3661 PMC5748609__F3 ASFV entry and uncoating 8411 5879 5058 967 1956 PMC5754225__F1 PI3K-AKT-mTOR signaling pathways in glioblastoma 5163 3667 5728 7248 6009 7249 2475 253260 6446 6194 PMC5765116__F9 DENV2-induced autophagy is ER stress-UPR dependent, involving PERK-eIF2Alpha-ATF4 and IRE1Alpha-JNK-BECN1 pathways 22926 83939 468 9140 8678 PMC5766603__F5 Phenylephrine synthesis 133 6503 5630 3240 100188864 4902 PMC5769535__F1 Neurotransmitters signalling pathways in cancer 2668 4803 59330 1956 3717 5979 2475 6774 3383 PMC5769625__F2 Layers of gene expression control in primed human PSCs 6657 79923 652 2247 3479 2885 324 1499 4087 4088 112590798 442912 10664 6651 63978 27086 PMC5773512__F6 Schematic to illustrate calcimimetic R-467 reversed Cd-induced signaling pathways, followed reinstated intracellular Ca2+ level and ROS generation, restored autophagic flux, alleviated cell apoptosis and stimulated cell proliferation 914 594857 846 PMC5775265__F4 Differential effects of HBZ on the Jun family proteins 3727 3726 6230 6667 PMC5777733__F12 Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer 10055 9063 8554 10401 51588 7018 PMC5777756__F8 Insufficient microwave ablation-induced promotion of distant metastasis is suppressed by Beta-catenin pathway inhibition in breast cancer 1499 51176 999 1000 PMC5783849__F9 TIPE1 and Wnt/beta‐catenin signalling pathway in gastric cancer 324 1499 4040 4041 PMC5789373__F2 Cross-talk of mTOR with other signaling pathways 5728 7248 6009 7249 4193 6497 PMC5790522__F7 Transcriptome profiling identified differentially expressed genes and pathways associated with tamoxifen resistance in human breast cancer 245973 91860 83886 2888 5296 10488 5799 9586 1386 84699 90993 2676 4313 64764 4318 5605 468 1388 5894 53358 3845 8503 5295 1385 5604 6655 3763 1839 208 3725 3765 23236 5567 5568 10000 25759 3760 5566 5266 6667 5330 207 2885 399694 3762 2775 3265 1956 2786 2773 5580 3320 2911 163688 2771 4846 6714 9568 4583 2770 2289 2550 2099 2776 108 114 801 3326 115 109 805 7184 2100 196883 2288 113 3710 2778 808 3304 4886 112 810 5331 4988 107 3303 3306 9915 147015 9947 260429 6496 10321 3310 2568 4753 284348 154664 10903 30812 8972 53942 6785 100191040 1472 419 PMC5793162__F1 Cancer cell signaling and regulation of alternative splicing 3845 324 1499 2932 673 2475 6420 6426 6432 6427 6428 5725 5315 5879 598 842 960 PMC5794834__F1 Complement amplification loop 629 1675 730 729 735 PMC5795461__F1 Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses 7099 81793 64127 114548 7098 51311 51284 3661 3665 PMC5796038__F3 Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis 7941 79576 2244 7124 312 3263 53947 139760 12 23547 84870 55734 5004 PMC5796186__F1 Malignant pleural mesothelioma disease progression 1029 4771 8314 64840 100188864 6608 5727 51684 9730 1499 2737 9113 26524 960 79633 PMC5796897__F3 The fatty acid (FA) synthesis in different cell types 47 2194 948 4023 7038 PMC5797050__F3 Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis 1611 367 4099 183 115209 PMC5797050__F4 Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis 4352 6722 355 1616 929 51295 7010 2316 4863 3725 4149 23118 PMC5801739__F2 Aberrant mTOR Signaling and Disrupted Autophagy: the Missing Link in Potential Vigabatrin-Associated Ocular Toxicity? 2563 2911 2916 6511 7474 2564 9568 2550 18 4586 5579 64223 6009 2280 1499 5696 9021 6774 2668 7422 PMC5804490__F3 Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an exploratory study 1356 222236 973 399 7175 4026 5583 5578 3065 814 351 2534 29760 11123 59339 PMC5805151__F1 Interaction between stress responses and circadian metabolism in metabolic disease 1628 406 9575 7494 PMC5807095__F9 Signaling events that are induced by the LH surge and regulate the processes of ovulation and luteinization 5618 635 5737 8862 8829 51705 23129 1583 6770 860 10682 PMC5807683__F5 Pharmacological targeting of KLFs in vascular inflammation 5465 23411 2475 688 8462 9314 10365 PMC5807685__F1 Canonical hippo signaling pathway 154796 60485 4485 9113 26524 55233 92597 10207 PMC5810219__F5 Canonical Wnt pathway regulates gene expression by modulating Beta-catenin levels 8324 4040 4041 324 1499 51176 PMC5810242__F10 The interrelationships among p-AMPK, p-mTOR, p-ULK1, autophagy and apoptosis 596 2475 8408 PMC5811049__F7 dWnt4 switches Beta-catenin dependence during oogenesis 1499 998 387 5879 PMC5811325__F2 Ras signaling pathways 2475 64223 253260 PMC5817811__F2 HGF/c-MET signaling pathway 3082 6774 2549 2885 5879 2475 PMC5819928__F1 EMT activation via TGFB 387 4087 4088 4089 999 1000 7448 117581 3423 9839 6935 PMC5821947__F1 Regulation of expression and functional role of CD38 952 3603 100126333 PMC5826217__F1 Insulin/IGF-1/PI3K/Akt/GSK3B/tau signaling 3479 3480 3667 8660 2932 PMC5826825__F2 Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development 1824 8000 8481 PMC5831137__F1 Dual-targeting Wnt and uPA Receptors Using Peptide Conjugated Ultra-small Nanoparticle Drug Carriers Inhibited Cancer Stem-Cell Phenotype in Chemo-Resistant Breast Cancer 22943 4040 4041 324 2932 1499 PMC5833124__F1 CX3CR1-CX3CL1 signaling pathway and migration process of immune cells via their interactions 3577 102 6868 1378 PMC5833345__F7 FBXL10-promoted DLBCL cell proliferation 9055 84759 54880 604 1848 PMC5833380__F3 ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells 3099 5209 2026 2023 5230 3939 5163 3309 25796 2539 2744 5226 2147 5211 7086 2597 6888 6513 2730 80871 100187761 PMC5833418__F9 Summary of the mechanism of NCK1-AS1 in CC cells 102465516 6667 5111 PMC5834288__F5 Myostatin regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway 2660 207 2932 23178 2821 5213 8789 5255 2997 226 5257 178 5837 2597 2027 5315 3939 3945 5058 5236 5230 PMC5834400__F1 Apoptotic signaling through the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) pathway 8772 637 8837 596 581 56616 PMC5835334__F7 Schematic diagram shows that TM suppressed the secretion of NO, TNFA, and IL-1B by reducing the bioavailability of copper and the activity of its downstream ROS/TRAF6/AKT/NFKB signaling pathway 54472 4615 7189 3553 4703 PMC5836099__F5 Mitotic arrest and slippage in inflammation and immunity 581 115004 3661 991 9184 55367 4975 PMC5841288__F9 Model of the Itch/Beta-arrestin2-dependent regulation of the SuFu/Gli3 complex function 4151 6469 6608 5727 83737 2737 51684 PMC5843896__F7 Our working model 183 9817 1499 358 2932 PMC5845882__F8 gga-miR-155 and the suppression of IBDV replication 7098 29110 3661 3665 10010 8651 PMC5846794__F6 Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy 5783 7534 2547 4790 816 817 4088 5599 3856 4087 5566 1147 815 88 207 1432 2099 3768 2309 1956 3551 3932 6640 6464 81 653361 6714 1756 4089 7402 5295 2885 356 58 70 1605 7532 6641 6300 2335 2934 55660 9493 5595 3706 5290 9846 PMC5847265__F1 Pediatric Pharmacogenomics: A systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children 3156 2222 1581 6713 6646 949 3949 4035 338 344 348 4023 345 341 1071 3990 5360 3931 337 19 64240 64241 PMC5852553__F4 Phosphatase and tensin homolog (PTEN) signaling pathway 2885 867 5728 572 PMC5852553__F9 Rac signaling pathway 960 5091 286 8851 998 387 2005 2002 3725 PMC5852597__F1 The Wnt signaling pathway that determines stem cell self-renewal 54894 8549 84133 324 6929 3931 PMC5852671__F3 Significance of selenium in cancer stem cell metabolism 57103 472 9997 10370 PMC5853106__F1 The Wnt Signaling Pathway in Cancer 4040 4041 324 1499 51176 PMC5853106__F3 Wnt Signaling Pathway in Cancer 4040 4041 6259 324 1499 PMC5854428__F1 Viral manipulation of STAT3: Evade, exploit, and injure 2690 1956 1271 9180 3977 3575 50615 3717 7084 3716 3718 7297 6714 5789 5788 2475 6774 11122 1844 10155 10401 9021 PMC5854681__F1 Differential control of distinct stages in adult SVZ-OB neurogenesis by different cell cycle regulatory proteins 5728 1020 23493 8841 6657 648 650 983 1017 1021 1869 1874 PMC5856294__F3 GPCR signaling and the organization of the stem cells niche 5741 1956 324 6774 84133 54894 81861 100499166 PMC5859251__F6 TRIM29 regulating anti-DNA virus immune response through targeting STING 115004 51428 29110 3661 23650 PMC5862315__F4 HFD activates genes involved in inflammation and tumorigenesis 3952 80326 6279 7477 9370 107 6280 4316 4057 4319 3848 4322 6696 114 3868 10804 4317 4922 11211 2625 9313 101 4314 6403 4318 90527 7473 5327 5228 338442 7480 6932 3162 1238 79148 57007 7040 29079 5770 2280 90390 8454 598 6774 6714 5747 3953 3717 PMC5862596__F1 Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas 2597 4397 355 1956 PMC5864212__F6 Deciphering the nature of the coral–Chromera association 57679 8411 967 3916 PMC5868458__F3 Protein expression levels of healthy cerebral cortex cells mapped onto the GBM pathway map from the TCGA data set 2638 7249 9118 PMC5869528__F9 Toll-like receptor signaling pathway 7097 5879 54472 10333 8772 114609 3929 929 23118 51135 7189 7099 958 54106 130749 3661 7187 7098 1513 PMC5870602__F8 Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform 860 121340 1277 632 1499 4982 3491 PMC5873983__F1 Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: a one-carbon metabolism candidate gene study 6948 2348 6573 113235 7298 4548 4552 57412 4522 4524 435 635 PMC5876067__F2 Inhibition of the BRCA1 DNA damage response pathway indicated by a down modulation (green; up-modulation is indicated in red) of atm, brip1, cdkn1a, e2f3, fancd2, fancl, mdc1, rad51, and rpa1 in male X 7808 472 466 2973 9656 126669 PMC5877574__F2 The signaling pathways in response to DNA damage and key effectors that interact with ER signaling 472 545 4193 995 993 983 1019 PMC5878942__F2 Physiology and role of irisin in glucose homeostasis 5465 3099 7019 5105 5837 PMC5882217__F3 Hippo pathway and cross-talk with other signaling pathways in mammals 6010 4771 154796 324 4485 9113 26524 1499 8473 51701 182 5784 9686 374 PMC5882221__F2 Ubiquitin-mediated regulation of the core Hippo pathway components 4734 26091 60485 4485 55432 6478 83737 11059 8239 51421 9113 26524 81847 8451 154796 55294 5784 PMC5882778__F2 Systemic metabolic cues with Kisspeptin, orexigenic, and anorexigenic neurons 5443 4852 181 5091 PMC5882792__F1 Mitochondrial UPRmt and UPRam stress response pathways 59286 468 22809 57506 8192 PMC5883534__F4 BRAF kinase inhibitor resistance and alternative activation of MAPK targets and pigmentation 2246 56034 1943 3082 2260 5156 1969 1844 1843 2034 7018 7043 107 1910 2771 5332 5566 4087 10413 2033 1638 4093 4286 10488 4948 PMC5884251__F1 Oncogene and tumor suppressor gene products regulate glucose and glutamine metabolism in cancer 4751 3099 57103 51548 2597 5230 5236 27165 2023 3939 5163 2746 2806 9997 65018 2805 5728 PMC5888819__F1 Dysregulated genes and their associated microRNAs in the KEGG MAPK-signaling pathway in colorectal cancer 627 4351 2885 6722 4342 6902 2645 355 1616 4149 978 51701 4200 PMC5889818__F3 Schematic overview of three different modes of cell death: apoptosis, necrosis and necroptosis 7124 8772 8717 8737 11035 197259 637 PMC5889982__F1 Beta-arr is a potential therapeutic target for various diseases 1956 7852 6387 2475 64223 2932 1499 PMC5891592__F2 CXCR4–CXCR7 crosstalk affecting signaling pathways 7852 4282 6387 6373 PMC5898751__F6 Phytohormone and MAPK signaling pathway 404685 7018 5597 PMC5904200__F2 Simplified scheme of established complement activation pathways 1401 717 2271 1378 718 1604 727 728 966 27202 719 PMC5905346__F1 GCs stimulate GSK3ß and inhibit Wnt signaling 4040 4041 324 2932 1499 5163 PMC5905465__F1 Structure of NFKB members.Notes: The NFKB family consists of three proteins with a transactivation domain (RelA [p65], cRel, and RelB) and two proteins lacking a transactivation domain (p105/p50 and p100/p52) 4055 958 5971 PMC5907676__F1 Wnt signaling pathway 11197 25928 387 5266 324 1499 PMC5908125__F9 Glyoxalase 1 (Glo1) sustains the metastatic phenotype of prostate cancer cells via epithelial‐to‐mesenchymal transition (EMT) control: involvement of miR‐101, hydroimidazolone (MG‐H1), argpyrimidine (AP) and TGF‐B1/Smads signalling pathway 2739 4087 4088 4089 7431 PMC5908130__F5 Perturbed gene network in placenta that may be reflected by the changes of circulating miRNAs in PTL 3371 7143 3791 7414 7082 2534 7408 5578 5728 3845 331 7157 4609 6714 2475 PMC5911217__F7 BRD7 regulates the insulin signaling pathway by increasing phosphorylation of GSK3B 4201 29117 2475 1977 2932 PMC5912671__F1 Fanconi Anemia 641 5888 672 PMC5918594__F4 Proinflammatory challenge and anti‐inflammatory drugs on expression of genes related to tryptophan and kynurenine metabolism 23428 117247 8140 6520 3620 125061 8942 4128 8564 23498 2806 7166 PMC5921304__F6 Metabolic enzymes belonging to the most divergent group (protein sequence identity) in the context of carbohydrate metabolism 11181 2539 25796 7086 PMC5921900__F2 Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges 6361 6367 56477 1435 6347 6387 8205 PMC5922974__F6 Genes directly effecting TAG biosynthesis in R 2203 7167 54820 3612 100996949 5131 47 2023 51660 25874 5105 5230 355 PMC5923376__F2 Hippo signaling pathway 9113 26524 8239 4485 60485 6478 83737 4734 154796 55432 PMC5924476__F1 Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome 7054 1621 1534 5409 PMC5925582__F7 Illustration of p204 function in LPS/TLR4 signaling pathway 929 114609 3654 51135 29110 10010 7189 3661 4615 PMC5925761__F1 One-carbon metabolism (1-CM) and pentose phosphate pathway (PPP) at the cross-road between anabolism and redox balance 26227 468 3845 4609 57103 5723 10797 PMC5927358__F1 Canonical Wnt signaling pathway 324 847 4040 4041 54894 84133 PMC5928215__F1 Protein and cell turnover of the skeletal muscle 7124 3570 3717 3667 5163 6774 4088 4087 PMC5929452__F3 Non-invasive tumor genotyping using radiogenomic biomarkers, a systematic review and oncology-wide pathway analysis 4605 864 5734 4772 4800 6929 5864 4773 7533 59345 1871 2113 2041 6667 1958 4778 840 3981 4613 2078 2033 2114 6498 572 5914 898 6909 7075 1910 5925 3492 468 3910 4609 6655 3815 1499 1311 1386 3575 6774 7056 596 3479 3298 2551 6850 5970 5156 5728 7010 5594 2305 2057 1869 2791 2846 7157 958 1870 10765 5241 3594 1147 5228 4763 1956 5894 3417 7097 3451 2056 2324 2256 23271 57521 5290 5287 5649 285 7039 2793 4256 2785 5578 1950 80310 9414 3845 126695 2258 429 7422 4255 1440 2252 3685 3485 5295 9180 4804 133 3265 3490 6009 3481 25759 768 3371 3777 55662 4316 5891 140 7531 2308 5447 2353 56034 2799 3915 1101 PMC5932236__F4 Pan-cancer molecular classes transcending tumor lineage across 32 cancer types, multiple data platforms, and over 10,000 cases 1374 1375 5163 5164 5166 5165 57546 54704 95 55066 1376 1737 1738 33 2180 2182 5132 51703 23305 5161 5160 5162 2194 5091 50 1431 4191 47 3420 3421 3419 3418 2271 4190 4967 8803 8801 8802 6390 6391 6392 23530 729 3714 10683 54567 182 28514 4851 4853 4855 4854 6347 1435 3091 968 3280 23493 23462 54626 1840 6362 6935 7431 8817 3586 6615 4318 9817 8452 5133 7422 5154 8312 1499 4780 324 3902 718 730 55511 4103 1485 942 941 962 8740 1493 7293 3604 51744 151888 920 919 3932 727 4199 10894 PMC5932832__F3 Proteins of acute-phase signalling at stage II compared with stage I in non-responders to autologous chondrocyte implantation (ACI) 5008 629 183 2335 3929 1401 350 197 3273 2266 57817 325 5340 2243 2244 4153 2147 1325 259 3263 PMC5938816__F11 Gene expression pattern related to TLR4 signaling pathway following epileptic seizure 7099 4615 54472 3661 3586 PMC5942188__F1 Review of craniofacial and dental findings of the RASopathies 6654 6016 4763 673 1431 PMC5943174__F1 Plasticity of myeloid-derived suppressor cells in cancer 383 4843 6348 3394 6774 PMC5943343__F7 Proposed Model: The figure shows that mutation in GNE inhibits sialic acid synthesis that may cause hyposialylation of IGF-1R 3479 10020 572 596 PMC5943909__F1 Summary of the proposed mechanisms involved in the regulation of gene expression by PNX in mHypoA-GnRH/GFP and mHypoA-Kiss/GFP-3 cell models 54328 2798 3814 PMC5944149__F2 The overexpression of tRNAs regulated the progression of cancer acting on different ways: Ras, c-myc and TERT promoted the transcription of tRNA genes by binding to pol III 7015 4553 2064 2065 PMC5946030__F2 Mitochondrial DNA mediates pro-inflammatory response 4615 54106 7124 1777 115004 29110 3661 PMC5946314__F1 Manipulating the PD-1 pathway to improve immunity 324 940 7535 PMC5949249__F1 To Eat or Not to Eat – The Metabolic Flavor of Ferroptosis 81539 6510 100 27165 2638 2879 8031 7037 PMC5949255__F3 Deciphering p53 Signaling in Tumor Suppression 54790 80312 1789 1788 6935 6010 800 23657 4193 1643 7508 4436 7057 283131 5784 115201 55102 10533 83734 8408 9706 7405 9997 PMC5950532__F6 Protein-protein interaction analysis of HOXA13-related genes in the first four Kyoto Encyclopedia of Genes and Genomes pathways 817 4060 27250 818 8321 117581 1956 2767 9475 960 55970 4254 23365 5468 5899 5578 3236 5728 2122 5337 5828 5194 5465 373156 8800 1962 847 6342 10257 2774 8799 90993 PMC5951826__F3 Wnt and Ras-MAPK pathway genes and interacting genes with AURKA, significantly deregulated (DEA) or in the most significantly deregulated gene module (Heinz) in the two cell lines, SW480 and Caco2 6790 1021 3932 7321 23405 5500 1499 1649 1487 27040 23179 3845 5534 3725 5880 9064 213 8573 2353 4254 5908 8313 5578 5337 5156 1847 29127 717 5530 PMC5951909__F8 NDRG3 lowers the metastatic potential in prostate cancer as a feedback controller of hypoxia-inducible factors 7428 57446 405 PMC5952256__F1 The mechanism of extracellular vesicles (EVs) release differs among different types of EV 4827 382 5062 3984 PMC5959917__F6 Schematic diagram explaining the mechanism of CSC maintenance in cervical cancer via let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis 1950 1956 8091 2475 6657 PMC5960217__F4 Wnt signaling pathway and multiple myeloma 6423 7481 1499 54361 7474 51384 7472 960 22943 3479 3569 PMC5962057__F1 Monoclonal antibody targeting amyloid B (AB) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer’s disease 718 3426 629 727 3553 730 729 735 6120 PMC5967641__F1 NAD+ biosynthesis, consumption and salvage pathways 952 23057 64802 349565 10135 4837 203447 PMC5969560__F1 Mitochondrial complex III Rieske Fe-S protein processing and assembly 7386 7388 1537 7385 617 7384 54902 2242 7381 PMC5971224__F1 Fatty acid (FA) and ceramide synthetic pathway in autosomal recessive congenital ichthyosis converge on the corneocyte lipid envelope (CLE) 59344 242 204219 643418 7038 84649 224 6785 5828 PMC5971270__F4 IPA identified “Tec kinase family signalling” as the canonical pathway in the cells with the highest predicted potential/significance of being affected by the treatment of caerin 1.9, based on iTRAQ data 8772 355 2353 8796 PMC5971440__F15 Arteriosclerotic G3BP1/RIG-I signaling in aortic VSM, a working model 4040 998 5879 10146 4776 57506 860 PMC5974094__F1 Potential immune mechanism involved in vaccination with G10E-CS 1431 324 920 PMC5979509__F4 VEGFR2 signal transduction and trafficking pathways mediated by VEGF-A 6714 6461 572 PMC5982769__F1 B cell receptor signaling pathway in mantle cell lymphoma 613 930 933 2885 4067 6850 79930 5728 387 695 867 6786 998 2922 8915 1384 1796 2475 958 1958 2002 1386 3725 29760 84876 126669 PMC5983871__F11 Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein 8729 375 5298 25801 5091 417 64746 PMC5983927__F7 Antitumor effects of corilagin 355 8772 581 637 PMC5984538__F4 NFKB and Wnt signaling pathways 4049 7124 3553 8717 7186 7187 7188 330 472 10454 23118 257397 840 4040 4216 27113 4803 5608 8313 324 51701 1499 4041 2932 PMC5984665__F1 MicroRNA Regulation of K-Ras in Pancreatic Cancer and Opportunities for Therapeutic Intervention 1956 2885 10252 5921 161742 4763 27250 5728 PMC5985449__F2 Sialic acid metabolic pathway 10020 54187 140838 55907 PMC5987207__F1a Systems and synthetic biology approaches in understanding biological oscillators 7465 7851 4118 324 8231 PMC5992426__F2 Venues of prenatal alcohol exposure (PAE) altering neuroinflammation 7099 627 3553 6347 2670 7412 729230 3383 PMC5992987__F4 Putative signaling pathway composed of FOXM1, MYC and miR-34a 55771 84823 3065 4839 4602 407040 1058 26147 10643 1062 6241 1869 2305 898 4609 142 4751 9134 1870 1786 4174 113115 699 11065 672 4172 5111 10112 6502 2146 PMC5993488__F2b Cumulative HLA class I and APM defects across gliomas from TCGA 3717 3659 4261 6891 6892 64167 PMC5994774__F5 Both mTOR and eIF4E phosphorylation are needed for polysomal recruitment of terminal oligopyrimidine messenger RNAs (TOP mRNA) 2885 5728 64798 64223 2475 9675 1977 PMC5995216__F2 Comparison of the LC3-conjugation pathway during canonical autophagy and Plasmodium-associated autophagy-related (PAAR) response 8408 9776 60673 83734 9140 9474 10533 64422 4077 PMC5995803__F8 Multiscale networks identified within neurons contain neuron-specific modules 92 25830 23365 27122 58508 91689 23155 2475 5170 114880 4724 28957 830 7514 1955 4774 816 51232 10260 224 23101 8813 63908 105371743 8420 28981 6143 151126 3421 11146 4763 60496 10013 55607 8727 6727 84918 9167 3843 3131 114134 108 6046 2045 23329 158358 84553 23062 604 10175 2258 51100 57169 202052 9960 5695 56919 92737 6429 2044 11183 92249 23641 27067 9406 55147 11127 57528 57731 79870 2932 3572 256472 55718 636 5687 51125 51727 23633 29093 140461 4833 6175 57520 5581 4660 2897 1933 27246 966 112483 5203 7025 6000 85013 57498 5879 222865 9143 6782 148423 4695 10810 29101 4792 6194 129563 10778 10735 23358 9991 55274 282991 659 PMC5998149__F5 Pathway analysis of selected metabolites 3033 100034703 100187761 PMC5999604__F1 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma 91653 6608 100188011 2932 51684 PMC5999604__F2 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma 51684 2736 2737 2735 8643 5727 2932 6608 6469 3549 50846 374654 91653 PMC5999746__F3 Reactive oxygen species (ROS) produce oxidative stress which in return converts the normal epithelium to early adenoma which leads to the next stage that is intermediate adenoma by the activation of EGFR signaling 4513 2885 1956 847 2353 PMC6002396__F8 Model depicts the multiple mechanisms by which NXT inhibits the development of diabetic nephropathy in db/db mice 7422 7040 3643 4313 7048 4087 2645 PMC6002513__F3 SIRTl/PGC-1A (FNDC5) pathway 252995 627 351 PMC6002803__F1 Reciprocal Signaling Between Translational Control Pathways and Synaptic Proteins in Autism Spectrum Disorders 5728 5163 7248 7249 1975 6009 PMC6002979__F1 B cell receptor signaling pathway 930 54209 958 613 4067 6850 695 29760 2475 84433 8915 7189 PMC6003649__F10 Signalling pathways involved in the intervention effects of PZC, PZD and PZE on TIF 1636 183 7048 324 4088 1499 4087 8312 4040 4041 PMC6003829__F8 R-loops cause genomic instability in Wiskott-Aldrich syndrome Thelper lymphocytes 7054 7150 1025 472 PMC6006200__F2 Fe/S cluster biogenesis 9054 7523 1675 PMC6009840__F1 Metabolic Reprogramming in Kidney Cancer 95 2194 3939 2744 5163 2876 435 445 PMC6012981__F5 Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes 3714 182 3394 28964 PMC6013441__F4 STRING pathway analysis of up- and downregulated genes in MDA-MB-231 cells co-cultured with adipocytes 8942 3399 27290 6781 5675 10397 4256 1366 1469 1843 8743 9518 1437 1958 3383 51655 3569 629 5743 4312 23678 4050 2920 11009 PMC6015873__F1 CAMKK2 as a molecular hub downstream in the bone–prostate cancer (PCa) microenvironment 10645 367 23636 100187907 1499 4772 650 PMC6016172__F2 Pathway linked to ER stress 3667 468 22926 PMC6017243__F9 The above-mentioned findings 5164 5163 595 PMC6022997__F1 Autophagy, apoptosis, and cell cycle arrest mediated by the activity of nuclear p53 protein (p53) in its function as a transcription factor in stress conditions 572 581 596 7249 2475 9474 9776 8408 4131 8678 PMC6022997__F2 Autophagy and apoptosis mediated by the cytoplasmic activity of p53 protein under basal conditions 572 581 596 57103 9100 2475 8975 9776 8408 8678 PMC6022997__F3 Illustration showing presumed mechanisms mediating suberoylanilide hydroxamic acid (SAHA)-induced autophagy 572 581 596 57103 9100 2475 8975 9776 8408 8678 PMC6027492__F2 Mitochondrial protein lipoylation 355 1743 387787 2653 11019 51601 PMC6028652__F7 Model of MAPK signaling pathway in MAP3K1; MAP2K4 wild-type or mutant cells 4214 6416 3725 1846 PMC6029133__F6 Cancer-related pathway-pathway relationships 5347 2305 545 4087 5159 5925 7852 1386 3579 2833 3565 PMC6029376__F7 Working model of the mechanistic interaction of miR-335-5p and CPNE1 in the control of the EGFR signaling pathway: miR-335-5p regulates CPNE1 expression via EGFR signaling in NSCLC 1950 8904 6714 1000 595 4318 PMC6033069__F4 The anti-inflammatory effects of MPQP on the LPS-induced inflammatory pathway 7099 4615 51135 3654 7189 PMC6034147__F1 Wnt signaling 7473 1499 324 2475 10642 9314 PMC6038164__F1 RhoA/ROCK1/LIMK2/Cofilin signaling pathway 387 6093 3985 PMC6038278__F1 Dysregulated genes and associated miRNAs in the KEGG TGFBeta-signaling pathway 25805 4089 100302142 3458 7124 8454 6500 7046 693168 6667 100302211 100313779 102466516 1616 387 3624 10468 4838 9978 442903 PMC6039551__F3 MicroRNAs (miRNAs) regulate innate host immune response against influenza infection by targeting intracellular signaling pathways 6280 7099 51311 51284 7098 57506 7187 7189 29110 3661 3663 3665 PMC6039985__F3 In PDA cells, E47 directed an integrated program of gene expression that controlled cell-cycle progression 7508 8190 2597 PMC6044036__F1 Metabolic cycles involved in methionine metabolism 6697 5091 4548 PMC6044348__F1 Schematic illustrating the current working hypothesis on IFNT signaling in endometrial epithelia and stroma of the ovine uterus 3716 7297 1471 3484 1474 1514 6513 2922 3290 5743 3660 3659 7084 6773 6772 10379 64135 9636 91543 6542 567 PMC6047740__F2 Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? 387 4919 4920 23002 5879 1499 PMC6048292__F1 Ferroptosis and its molecular regulation by Nrf2 2937 5226 2539 2879 PMC6050934__F7 NOX4/TRPC6 pathway is important in podocyte calcium regulation and renal damage progression in diabetic kidney disease 6098 50507 7225 367 PMC6052671__F1 TGFB1 signaling cascade leading to EMT 1080 100616437 4087 4088 406937 4089 999 1000 PMC6052888__F5 Tryptophan metabolism mediated immune cell response 324 2475 196 23410 PMC6052888__F8 Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism 6098 8452 9817 2475 4609 920 PMC6054540__F9 Regulation of hepcidin in breast cancer spheroids 654 4089 6774 PMC6056039__F1 Calcineurin pathway in T cells and amplification of NFATc1/A 940 27040 3702 7535 4772 2353 4094 3558 PMC6056224__F1 Imbalanced expression/ activity of RAD18 and Y-family DNA polymerases dictates choice of TLS polymerases and can influence replication fidelity and genome stability 353497 56852 4103 11201 51455 51426 PMC6056231__F9 Neural crest induction by Dkk2 and Wnt8 4041 4040 27123 8312 1499 6591 PMC6061680__F1 Toolbar, graphical elements supported in SPV and the mTOR pathway 3630 5728 7249 6194 57521 5468 6886 6009 PMC6063915__F3 LSEC and KC signaling pathways in 3DHLK systems 51703 2181 2182 23305 255738 51 35 34 3949 1962 1718 3156 3033 2222 38 39 10449 348 5465 1581 1593 9846 1582 2205 PMC6063970__F4 Mapping transcripts on KEGG pathway 3240 5728 2475 472 545 4193 5447 8638 100188776 572 PMC6065049__F6 PKC pathway for prolactin regulation of the metabolic genes for citrate-producing prostate cells 5617 3725 2353 PMC6065472__F7 Enriched pathways for radix tetrastigma hemsleyani flavonoid treated lung cancer cells 847 1950 867 367 1398 685 1839 4609 126669 2885 3084 9542 2475 572 10718 145957 2353 4342 4763 2316 3727 7124 7186 355 1616 4149 8195 4208 10454 929 23118 51295 51701 6714 627 PMC6066232__F1 Study of purinosome assembly in cell-based model systems with de novo purine synthesis and salvage pathway deficiencies 5471 2618 5198 10606 158 471 PMC6071020__F5 Neurotrophin signaling pathway and genes involved in the significant gene links (marked in red box) 1398 10818 627 126669 572 6476 7189 581 6010 5879 PMC6072563__F1 Schematic represents various signaling pathways that occur within tumor cells, which allow for cell growth, proliferation, and invasion 1956 3716 6774 1021 1019 PMC6073502__F3 Interaction of proteins 3 days after hyperoxia 5037 213 119 60 2923 70 2203 2805 7416 5641 7001 2023 4190 6612 10576 PMC6073700__F1 Activation of the growth hormone receptor and its signal transduction 11319 3717 6774 PMC6078353__F4 KEGG pathway functional analysis of differentially expressed genes 387 7408 5728 572 3611 1793 1398 PMC6079259__F2 Mechanism of Homologous Recombination (HR) 472 9156 5888 PMC6085474__F7 Regulatory pathways of ERBB2+ GC 9542 4609 2064 5914 PMC6086774__F1 Lipid metabolism in tumor cells 948 2180 95 2194 47 847 7038 PMC6086983__F4 Scheme of the mechanism by which pioglitazone (PIO) regulates hepatic metabolites, lipids and related gene‐expression patterns (italicized) 948 84649 355 65057 95 5091 7038 10162 PMC6088210__F1 TLRs mediated the T cells response and programmed cell death process toward tumor environment 7054 920 4615 114609 8205 940 941 942 7189 29110 2353 8717 8772 3661 PMC6092675__F8 Inhibition of mTOR activity with rapamycin 7939 2475 4087 4089 7046 PMC6097677__F1 Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition 64065 5111 367 11073 1869 PMC6100359__F1 Insulin signalling pathway activated in retina and RB 867 355 85451 3630 3643 7249 6009 572 2475 1977 2885 2002 2932 PMC6102449__F6 Working pathway for Er-Miao-Fang inhibiting inflammation and blocking hepatic gluconeogenesis 3553 5142 5140 PMC6104488__F2 Schematic illustration of the PTEN regulated PI3K-AKT-mTOR signaling pathways in CNS axon regeneration 5728 5163 2932 PMC6105545__F6 Persistent EcoHIV infection induces nigral degeneration 1236 3458 2597 4790 6347 6714 3586 3578 7099 3567 PMC6108866__F4 Role of EpCAM in cell signaling 4072 4040 5091 2274 3266 1499 324 51176 27123 PMC6109707__F8 Complement activation and involvement during alcoholic liver disease 718 717 721 727 7124 PMC6113426__F3 Summary of apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like (APOBEC)3B transcriptional regulations in cancer cells 7124 5091 545 472 5971 1874 286826 PMC6114477__F1 Tumor-associated macrophages and epithelial-to-mesenchymal transition in hepatocellular carcinoma 1950 4922 4317 5311 387 4088 4087 3172 4318 998 4089 6774 2932 3577 2296 1499 999 9839 6935 1000 PMC6114477__F5 Virus-related products in the inflammatory tumor microenvironment 2932 6774 3481 5494 4318 4513 PMC6120164__F1 Network of “Target-Pathway” in osteosarcoma (OS) based on the collected data from – 7084 8445 9263 23531 142 55680 5226 23139 5756 11011 2872 5775 9422 80351 6319 23279 55852 6645 81537 167227 6426 1982 58528 7298 91775 5198 4170 221035 3791 445347 54619 26523 10951 6095 64065 6497 57532 6651 23788 1198 27230 1948 51098 3654 1956 10890 3915 9341 PMC6121065__F1 mBDNF/TrkB and proBDNF/p75NTRsignaling pathways regulate gamma-aminobutyric acid neurotransmission 387 126669 5728 PMC6122186__F1 Hippo signaling pathway 60485 4485 9113 26524 PMC6122186__F2 Simplified illustration of YAP/TAZ and glycolysis 5209 8473 3099 2736 400500 2303 PMC6127653__F2 Role of p21-activated kinases in Kras-driven oncogenic signalling pathways 3845 998 5879 5163 1398 133 PMC6128733__F1 Neurotrophin Trafficking via Trk Receptors 23557 4803 5879 1960 4209 6722 PMC6136787__F4 Newborn blood DNA epigenetic variations and signaling pathway genes associated with Tetralogy of Fallot (TOF) 4199 8544 150365 PMC6137035__F7 Pathway schematic 768 7428 3091 6774 PMC6139299__F1 Schematic overview of light-regulated translational control pathways in the SCN 2475 1977 7432 PMC6141435__F1 Hippo signaling pathway in Mammals 166824 4485 4771 60485 79633 84962 PMC6141803__F2 Indoximod mechanisms of action 169355 3620 196 8564 PMC6144355__F1 Molecular mechanisms of TNBC 1956 367 4092 999 5728 1499 558 324 4089 2475 2114 2113 2002 4609 PMC6146524__F4 Galactose metabolism, glycosylation and inflammatory cascades in galactosaemia 2592 101448070 7360 2582 4248 79796 2530 301 3383 3953 3952 7358 PMC6150107__F3 Role of HDACs and associated pathways involved in the processes of autophagy during the progression of DN 8841 10533 2308 83734 64422 8408 7249 3091 PMC6150497__F3 Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator 9021 3667 7132 8660 9314 55636 5728 5163 6311 334 253260 7248 2931 9882 10890 23186 2997 207 PMC6150985__F2 P53 is the most important regulator in DNA damage 545 472 581 PMC6155514__F5 Real-time carbon allocation into biogenic volatile organic compounds (BVOCs) and respiratory carbon dioxide (CO2) traced by PTR-TOF-MS, 13CO2 laser spectroscopy and 13C-pyruvate labelling 5132 3652 4015 PMC6156150__F7 Proposed network for AhR-Src-STAT3-IL-10 signaling pathway in inflammatory macrophages 7099 929 6714 4615 196 6774 PMC6156235__F6 A schematic illustration of how dipalmitoylphosphatidic acid (DPPA) might inhibit angiogenesis in breast cancer 1523 2246 3082 PMC6158718__F1 PI3K/AKT pathway 3667 5728 5163 7249 7248 4609 6009 572 4193 PMC6158718__F2 PI3K/AKT pathway in muscle tissue when normal state and insulin resistance 7038 29904 1977 1975 PMC6159521__F4 Schematic drawing of the asymmetric specificity of the EndoMS-dependent MMR system and asymmetric occurrence of replication errors 23464 2638 727 PMC6160419__F5 Extracellular matrix organization pathway genes in COPD disease network module 2006 10144 9507 4015 2201 22795 2022 4054 1805 2200 3549 114990 1511 8614 2192 4316 650 4060 4312 4237 6649 1141 1137 847 11005 633 1991 4320 1139 30008 260431 4318 5644 4321 PMC6161481__F8 The proposed pathways activated by LPS to modulate mTOR-dependent autophagy and the production of pro-inflammatory cytokines in Caco-2 and HT-29 cells 4615 23118 10454 2475 3553 7099 PMC6161735__F1 Nrf2/Keap1 signaling pathway in homeostatisis and stress 8452 9817 4094 PMC6161739__F3 NLRP3 priming following TLR activation 7097 7099 7098 4615 51135 3654 8772 114548 PMC6162436__F3 Repurposing of drugs on YAP (Yes-1 associated protein)-TEAD (transcriptional enhanced associate domain) system through cross-talking pathways 3667 2885 6010 4485 154810 51421 2932 9113 26524 84962 1499 558 PMC6164903__F2 Induction of innate immune response by viral infection 7098 54106 51284 4615 29110 3661 3665 PMC6167061__F2 (A, B) Intracellular pharmacological chaperoning and matchmaking of G protein-coupled receptors (GPCRs) and downstream effects 22926 468 83939 7494 PMC6167446__F1 Pathogenic roles of NLRP3 inflammasome in liver diseases 51284 7099 10628 114548 3553 PMC6168630__F1 PI3KD activation in B- and T-cells during class-switch recombination 613 27040 7535 5728 29760 57379 7374 5897 PMC6169299__F8 Signalling pathways in the TLR response 929 6352 6348 7099 4615 6351 3654 958 941 3665 3627 51311 51284 4283 3661 7098 7187 29110 PMC6172368__F2 PPI network constructed based on the genes with differential expression between the M2 and M0 groups in the intersection of GSE18686 and GSE35449 11262 9447 118932 6504 1382 654817 51513 246778 83666 653361 116071 57823 3429 10346 8651 3134 3669 3620 55601 91543 8519 2643 3606 3569 54739 57169 3659 64135 6775 3437 6890 6773 6648 79901 2633 3433 9636 7100 952 51056 2878 341 4023 115361 3665 2634 7130 54625 6355 5328 5743 4502 29126 4496 949 5721 2170 5693 3959 4501 2034 6916 4489 5168 1593 5698 4494 4493 4495 3627 10964 PMC6172368__F3 PPI network based on the interaction of the differentially expressed genes between the M2 and M0 groups 4048 2745 6503 366 5583 6648 4778 7466 6280 929 6279 10875 5468 10644 902 1647 64170 1536 50856 80896 5218 4615 1026 8651 51284 3662 30835 890 911 2208 182 81029 1593 8854 5209 7298 910 2060 2535 9023 5214 10901 913 51659 6641 9363 6367 909 1837 6361 7083 113130 PMC6172368__F5 Sub-networks constructed based on the differentially expressed genes identified in the communities of interest in the protein-protein interaction network using CFinder software 51056 51284 116071 3669 54625 54739 366 2634 2633 929 30835 911 3429 115361 3606 10875 1536 8743 3569 8651 50856 4615 3437 23321 29126 3659 PMC6173648__F6 A hypothetical pathway that may underlie vibration-induced changes in gene transcription in the prostate 3603 6490 580 PMC6177618__F1 Calcium‐sensing receptor signalling and trafficking 8544 2271 5741 PMC6185797__F1 GSK-3 regulated signaling pathways and splicing factor phosphorylation 4040 4041 1499 324 PMC6186824__F2 BAFFR-induced intracellular signaling 613 930 695 5336 29760 7186 7187 2475 5971 6502 2002 1977 6850 PMC6187079__F1 Mammalian autophagy-lysosomal pathway (ALP) 7942 2475 60673 9776 8408 22863 55626 84141 10013 4077 9140 8878 1499 10533 4851 64422 83734 PMC6189293__F1 Complex interplay between O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway controls numerous biological processes 2475 7249 8473 PMC6189633__F3 Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity 847 83464 2820 22906 1374 120892 2936 9377 5663 7416 23621 64756 1431 10935 5601 836 1743 PMC6192633__F8 GPR108 works as a dual functional regulator to balance the TLR-triggered immune response 56927 7099 7189 4615 100187907 114609 PMC6192719__F5 Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches 1734 2039 2034 1499 79791 50486 920 79885 847 596 80830 8862 51056 51096 5594 10367 7124 55959 8828 6781 6535 9554 5271 9123 6518 4311 PMC6193072__F1 Canonical NFKB pathway 5971 10892 8915 1540 50943 7852 PMC6193563__F3 Metabolic reprogramming of the tumor microenvironment by p62 and its partners 7421 4077 9817 7189 PMC6198389__F3 Possible therapeutic strategies for cancer stem cell elimination 9429 960 2475 1499 PMC6198670__F5 ARG1-arginine-immune suppression-fatigue pathway 3596 3565 383 939 940 1236 PMC6198802__F3 Key cellular and molecular pathways regulating blood-brain barrier integrity 6469 4035 4089 7422 5159 284 7048 5727 2048 182 PMC6199358__F1 (Left) In the “off” state, Beta-catenin binds with glycogen synthase kinase 3B (GSK3B), axin2, adenomatous colon polyposis protein (APC), and casein kinase-1 (CK- 1) 324 4040 4041 1499 595 8313 PMC6203329__F2 Cellular oxidative and genotoxic stress responses converge on the AMPK/mTORC1 pathway 472 7249 7248 6009 PMC6204183__F3 Neuropeptide signalling pathway (GO:0007218) enriched by genes that showed higher expression level in the hypothalamus of 3-week-old than 6-week-old cockerels 4828 5367 4852 10874 5443 2691 1081 PMC6206851__F1 Cellular Mechanisms of Estrogen Action 3169 1950 3725 2353 2638 PMC6209820__F5 Major pathways of cancer immunotherapy of Ganoderma in immune cells 4703 2152 10171 929 PMC6211039__F2 Unfolded protein response pathways 7186 22926 468 83939 PMC6212521__F7 Schemes of normoxic vs 2271 4118 1431 PMC6212521__F8 Schemes of normoxic vs 2271 4118 1431 2638 PMC6213852__F1 Host metabolism and cytokine induction 2475 4615 115004 9927 29110 3661 3091 57506 PMC6216032__F4 Smad-dependent/independent transforming growth factor-beta signaling pathways 387 7018 467 PMC6217807__F5 Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma 5728 3630 3091 574 572 PMC6218458__F1 Canonical Wnt pathway and the role of the LRP6 receptor 4040 22943 324 1499 PMC6218864__F8 Simplified schematic of the effects of nephron-specific Jab1 deletion on the CUL3-KLHL3-WNK pathway 8452 26249 65266 130497 PMC6219086__F5 DE genes on “Wnt Signaling Pathway and Pluripotency” pathway upon S 5578 5584 5579 5583 5590 5587 5581 5580 5582 1855 387 5602 8313 324 5048 6934 79923 4609 1499 4800 1401 85409 2033 85407 5467 10009 1387 6657 3725 4316 55844 5520 5328 5523 10023 6885 6929 1500 PMC6219086__F6 Insulin signaling pathway 3643 5290 5291 2885 5894 2888 25759 53358 5293 8660 8471 5294 2549 5288 5289 6655 5213 5211 3991 5595 5596 5597 4216 5598 9064 2997 2998 10110 7248 207 7249 208 2931 2932 6009 6885 5792 5601 5578 5602 5770 5580 5600 4294 6300 5603 4296 7786 1432 5728 375 2319 5583 382 57381 5867 5584 5781 867 868 4641 5588 6812 9020 3631 1978 6813 5590 5606 6416 5871 1977 57761 6814 252983 6844 8651 1398 2889 5562 10938 9021 6722 5563 3551 30846 9448 5608 1958 23433 7494 2353 3725 8773 6616 5286 3667 6464 2887 6236 6654 5879 4214 10746 4215 1326 4293 9175 11184 8491 11183 50488 5594 5599 5170 5167 5501 2992 3636 10211 10580 11127 10487 9882 5607 23624 2002 355 PMC6219741__F8 The proposed mechanisms of over-activation of UPR to trigger apoptosis 5728 83939 23030 1939 468 467 PMC6222750__F6 Proposed signaling pathway triggered by kaempferol in EJ cells 637 572 581 472 595 PMC6225148__F2 Current understanding of the mechanism of action of T-oligos 472 1869 581 PMC6225658__F2 Representative image of the anti-angiogenic potential of autophagy 5178 7475 2922 PMC6225799__F6 Activation of the interferon-ɣ/STAT1 pathway 204 8651 581 PMC6232560__F3 Oncogenic signaling network activated by bile acids 1956 4320 4312 6774 PMC6232868__F1 Schematic representation correlating various factors such as light, eye, melanopsin, pineal gland, vitamin D, intestinal calcium, and gut microbiota to neuroinflammation and MS 929 7099 7124 PMC6235217__F2 Pathway analysis within the identified metabolites in the (a) tocilizumab plus methotrexate, (b) tocilizumab, and (c) methotrexate strategy arms 4015 253782 5091 4018 4512 4513 PMC6235888__F6 Schematic pathway summarizing the manipulation of GAL via the activation of A7 nAChR to mediate its anti-inflammatory effect 51083 5970 9021 3146 PMC6237934__F1 PD-1 signal inhibits T-cell receptor (TCR) signaling pathway 324 3932 7535 207 6502 10538 2475 2308 4772 PMC6242703__F1 Simplified diagram of transcriptional pathways and targets for intervention for AUD treatment 627 4852 1325 PMC6242950__F3 Caspase-dependent apoptosis pathways in myofibroblasts 355 8772 6609 6010 5728 572 637 581 596 PMC6247426__F1 Metabolic reprogramming in HCC 948 3099 2539 2194 2597 1636 47 4118 3939 11113 3945 PMC6247912__F2 Somatic mutations of the canonical signal transduction and tumor suppressor pathways in HCC 2064 1956 7253 5979 7517 672 7508 2073 472 3265 4763 3845 5728 673 11200 7157 2177 2187 4436 4437 7248 7249 5426 5395 1869 5371 9874 6009 2475 1975 1964 7458 1977 54617 546 1788 1786 10847 2074 80312 54790 26038 57680 1108 55349 80205 1106 56916 6603 6046 1387 29072 6419 64324 23067 29117 114826 4297 8085 58508 84148 2145 51548 84678 8242 23081 8289 221037 5253 7808 1111 PMC6249032__F2 Overview of Cdc5 functions in key cell cycle pathways 10518 983 998 10276 PMC6249818__F6 Therapeutic targeting of the FOXM1 genetic network in myeloma 1019 2305 4751 PMC6255774__F8 A simplified diagram of fatty acid synthesis, modification and assembly into triacylglycerol in developing Arabidopsis seeds 5091 54947 79888 PMC6258005__F3 Mitochondrial Fatty Acid Synthesis is the puppet master of mitochondrial biogenesis 95 2242 4715 4700 154791 PMC6258145__F6 Pictorial Abstract showing that the molecular or therapeutic inhibition of TRPM7 expression and/or activity attenuates the cancer stem cell-like and metastatic phenotypes of lung cancer cells through the modulation of the Hsp90A/uPA/MMP2 signaling 1000 4313 54822 999 6657 9314 PMC6259838__F1 Cell cycle pathway represented in KEGG 9126 10274 10735 5885 1874 4087 4088 4089 6502 9184 699 5111 993 1017 1022 983 990 4661 1869 8317 10926 23595 PMC6263145__F2 Mitochondrial Quality Control in the Diabetic Heart 9140 8408 9776 60673 2475 PMC6265005__F1 Tumor necrosis factorA pathway for necroptosis 7124 8717 8737 7186 8772 11035 197259 PMC6265603__F1 Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer 3479 3481 5728 5163 8473 57521 PMC6266939__F1 Main components of the Hippo pathway and the current Hippo-targeted inhibitors discussed in this review 3611 60485 6010 154796 983 PMC6268005__F2 ERAD regulation of cholesterol metabolism 3156 29914 7327 7415 PMC6274245__F5 Upstream signal transduction pathway leading to activation of canonical p50/p65 NFKB upon stimulation by tumor necrosis factor (TNF)A (see text for details, scheme realized with ScienceSlides) 7124 8717 23118 7186 10454 PMC6274888__F1 Response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function 2735 6469 383 7852 PMC6275025__F1 Insulin signalling pathway 3667 5163 5728 8660 8471 2932 PMC6275040__F1 Schematic representation summarizing the transforming growth factors-beta (TGFB) receptor complexes and signaling pathway in endothelial cells 7939 64093 116844 4089 4090 4086 4087 4088 PMC6276109__F1 Breast Cancer Stem Cells: We’ve got them surrounded 1956 2833 6714 5728 6774 1540 5970 PMC6277552__F1 Iron metabolism in prostate cancer microenvironment 8205 149998 3569 PMC6277854__F2 Major signaling pathways and therapeutic targets in CLL cells 613 1499 182 7852 6850 695 6010 1386 3725 4609 51176 4170 572 581 4318 PMC6279409__F2 Sensing danger through a “finger” 920 4615 108348016 7555 PMC6280669__F2 Proposed TLR signaling network modified from previous reports (; ; ) 7096 929 51135 5879 7189 3654 7187 3665 3661 958 3553 941 942 114609 PMC6280671__F4 Integrated Analysis Reveals Genomic and Expression Alterations in Signaling Pathways in HNSCC Differing in HPV Status 8795 658 2260 1956 5290 8772 1857 5296 5983 2931 207 208 10000 545 4193 2932 841 1111 472 329 79923 836 389 2997 2475 330 5519 1026 2308 10039 2810 8658 4793 1977 5925 5728 1499 5347 PMC6283278__F3 Mitochondrial quality control mechanisms as molecular targets in cardiac ageing 3479 207 6009 8408 7942 PMC6288913__F1 HCV life cycle and involved Rab proteins 1950 1969 3949 975 1956 9076 9545 8766 5873 7879 51762 5872 51715 10981 81876 22931 PMC6290262__F1 UPR activation 7494 468 22926 PMC6292929__F1 CBL0137 exhibits its antitumor activity via multiple pathways 867 4613 4851 3297 PMC6296341__F1 Two synthesis pathways of fucosylation 2762 2525 2523 2526 170384 10690 84750 2530 2524 2529 2528 2527 PMC6296511__F3 Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study 2149 2152 3053 1361 2155 2159 2147 2153 2158 7056 462 2 5624 5054 5265 5627 5327 5328 5329 2161 5340 3818 5345 3827 623 3426 1191 729 730 733 735 5648 718 10747 721 717 712 713 720 719 1380 710 1378 7035 716 PMC6296821__F1 Ex vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery 2885 3717 3563 PMC6298254__F1 Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway 7124 8717 83737 7186 8887 26994 1540 90268 8772 10454 841 23118 81858 PMC6298254__F3 Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway 7124 8717 80013 841 8772 9294 1540 222484 57506 64770 10454 7186 10024 23118 4629 7188 153733 9618 9662 7187 1070 5557 8481 200081 7185 9230 8574 10133 79465 729852 23609 4291 55432 6772 8887 81858 154796 9367 71 1719 154810 8324 2664 26002 23413 79625 7706 55714 27246 2802 25989 159195 PMC6300778__F8 JAK2/STAT3 mediated protection of APN against OGD 6774 3717 8178 PMC6301029__F4 Egg activation in Drosophila 324 983 2932 PMC6305653__F2 Signaling pathway analysis of KEGG and PANTHER pathways shows that the miR‐34a/BCL‐2 axis is mostly involved in apoptotic pathways 839 355 8772 836 8717 841 7186 637 2021 4615 842 572 3562 472 759 100506742 581 PMC6307990__F7 The proposed model is a graphical representation of the mechanism of interaction of IDO1 and IL6/STAT3/PD-L1 in EMT regulation in bladder tumor cells 3569 6774 3620 PMC6311107__F2 Simplified model of the molecular pathways by which pazopanib and AR42 combine to kill cancer cells 6648 5894 7249 572 2475 8408 581 637 472 9776 83939 10013 3066 83933 79885 PMC6311899__F3 Result of newborn mouse lens epithelial cell 2260 5894 2475 1147 6714 5566 6788 51701 5747 6446 5991 79733 7546 5971 6886 6657 2736 5990 22877 2737 22882 2118 4602 6932 64344 51176 4853 8321 4040 4854 83999 8549 5364 6382 1903 775 100506658 107 1464 6869 8325 2535 7976 4036 8322 7855 4855 8324 4756 3643 2263 5156 1948 4035 2149 1000 3688 4041 3676 5362 657 7046 5787 2817 6383 1004 54933 6259 5797 2262 9620 3916 147495 5080 90993 4306 PMC6314011__F3 The interplay between intrinsic (i.e., circadian clock) and neurohumoral factors in circadian control of both metabolism and redox tone 5295 3099 84649 PMC6314014__F1 Top network depicting the influence of high fat diet on mammary tumor gene expression (Ingenuity Pathway Analysis Knowledge Base) 140628 3043 3040 3039 2627 1048 5603 177 5728 8550 6289 1284 7124 2255 836 1655 290 10397 8877 3939 3646 8837 5591 26986 1981 8672 PMC6314014__F2 Top network of metastasis virulence biomarkers (Ingenuity Pathway Analysis Knowledge Base) 80176 5176 10135 165 4016 8829 2697 2006 633 91179 3339 7043 4811 1524 5118 1513 2217 11167 7076 116844 PMC6314674__F1 Metabolic pathways controlling macrophage activation states 3458 355 999 383 4360 9902 3603 PMC6317954__F4 Metformin combined with Abs or small molecular inhibitors in cancer treatment 3479 1956 2475 PMC6321280__F1 Components of the Hippo-YAP signaling pathway 4485 9113 26524 60485 PMC6321285__F1 HGF/c-MET signaling 3082 2885 2549 5879 6714 6774 5058 2475 PMC6321489__F3 Scheme of the main steps for autophagy and their regulation by AMPK 64798 100170220 60673 9140 83734 10533 64422 9776 PMC6323245__F1 Different stages of erythropoiesis and regulatory processes (including cytokines, transcription factors and related signal transduction proteins) 6886 2624 3480 3717 3479 2057 2549 4067 2623 4778 8328 2056 PMC6324668__F1 Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins 7150 3014 55775 7157 545 91607 PMC6328441__F1 Upstream regulatory pathway of CHOP 22926 83939 468 PMC6328967__F4 Interaction between Wnt/Beta-catenin signaling pathway and HCV core protein 999 324 4041 4040 PMC6329310__F2 Role Of Atm In Ebv Life Cycle Regulation (A) The central role of ATM in the replication compartment of EBV 6667 5893 472 5888 648 4609 PMC6331066__F7 Model for EBV related chemoresistance.Notes: EBV activates the ATR-mediated DDR pathway, which is characterized by enhanced phosphorylation of the pathway proteins RPA32, CHK1, and H2AX 545 5888 3014 PMC6333638__F3 Cell-intrinsic PD-L1 in modulating signaling pathway 6774 648 79923 2475 720 PMC6333681__F1 Environmental pollutant-induced obesity and metabolic diseases: involvement of BAT impairment 1652 7808 63976 5468 PMC6335273__F4 Three main features (GSIS, beta cell mass and insulin action) and insulin secretion pathway in GK rat 572 90673 3416 9734 2693 109 6514 778 115 54097 3174 2645 6833 5507 PMC6335494__F7 Schematic model of intracellular signaling mechanisms regulating proteasome inhibitor-induced apoptosis by FLT3-ITD involving the STAT5/Pim axis and the mTORC1/eIF4F/Mcl-1 pathway 1975 581 4170 PMC6337236__F2 Iron handling in the tumor microenvironment 920 57817 3458 654 4089 4090 4086 9843 6774 7018 3934 9332 1950 3553 PMC6338075__F5 Rhythms of life: circadian disruption and brain disorders across the lifespan 7054 885 4128 406 9575 23411 PMC6338098__F2 TGF-beta signalling in bovine mammary gland involution and a comparative assessment of MAC-T and BME-UV1 cells as in vitro models for its study 7040 4089 4087 4088 572 PMC6338918__F1a Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis 83756 23274 132864 10178 23228 57495 26578 351 56243 860 6474 59269 1301 57479 7475 4969 112495 55186 3281 PMC6340394__F4 Black-Box Illuminated: Signals and Signaling 2152 4734 25942 2799 100188776 441478 4609 1021 PMC6344597__F6 The amino acid catabolism pathway differs in breast-fed (BF) and formula-fed (FF) infants 718 717 727 PMC6345743__F5 Comparing ECM-receptor interaction pathway for (a) DA and (b) non-DA neurons based on DEGs and DEmiR 7927 355 1277 1297 1101 3688 6476 6696 7057 7059 766 9899 765 375790 1311 7054 51083 759 3912 5970 3909 3918 PMC6348685__F4 Putative genes and their expression patterns in the biosynthetic pathway of astaxanthin in H 2224 79947 266710 PMC6349186__F4 Wnt signalling pathway uniquely identified by ce‐Subpathway 51701 9350 25805 50964 6500 324 9475 27130 2033 4089 51176 6934 23291 1537 6477 387 PMC6349186__F5 MI‐related subpathways where key nodes are annotated 1398 10818 2885 4803 627 2549 3667 572 581 387 7408 3611 6714 5728 998 2002 126669 PMC6349702__F2 Protein-Protein interaction network of the 214 identified proteins: network nodes represent proteins, network edges indicate the strength of data support (STRING v10.5) 9446 8428 2950 2040 136319 5548 117159 4354 4860 7317 4191 7171 3418 27434 5478 1178 387 10982 5196 6714 7057 5341 5901 10971 6403 10855 8775 5872 5899 11343 91624 5479 6876 4830 4831 654364 59330 832 1265 7170 367 3987 5473 267017 3043 30845 PMC6351542__F5 S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy 7481 11211 2776 80271 6261 3709 6263 PMC6352191__F6 Protein–protein interaction (PPI) network in cluster 1 from the MCODE sub-network analysis 8519 94240 5359 4939 4599 4600 10379 79132 55008 6772 83666 54809 55601 64761 3431 1822 4940 7150 4967 1956 10561 5610 7316 9636 57506 11274 9140 351 6714 1994 3659 5435 54739 604 64127 329 PMC6352924__F2 Tumour necrosis factor receptor 1 (TNFR1) signalling pathway 7124 23118 257397 8717 7186 7188 8737 1540 11035 8772 197259 PMC6352980__F2 Paths to stemness: building the ultimate antitumour T cell 11009 3976 652 4041 4040 6774 4087 4086 324 2932 1499 7249 60485 4485 2475 4089 9113 26524 10365 6929 9314 1852 3399 3397 PMC6365940__F9 Pathway involved in gemcitabine-resistant pancreatic cancer cells with digoxin treatment 4094 9817 2729 1728 10057 PMC6367275__F2 Schematic and simplified representation of the several components of the IGF-1/PI3K/AKT/mTOR pathway discussed in this review 3486 3479 3480 2885 572 64798 PMC6367587__F9 Schematic map describing apoptosis induction of the TRAIL and Andro combination therapy 8772 637 581 PMC6368838__F4 Identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes 79832 1958 51318 147923 579 84292 26205 7593 10522 5294 1121 10890 55017 10135 PMC6370526__F1 Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology 22926 7873 7186 468 PMC6370632__F1 Signal transduction pathway related to the immune-regulation of botanical polysaccharides in macrophage activation 929 7097 4615 7189 3725 2353 PMC6372678__F6 Mitochondrial superoxide dismutase 2 mediates Gamma-irradiation-induced cancer cell invasion 55959 1499 6774 6648 6714 PMC6372765__F1 Signaling pathways involved in sarcopenia , 10220 3479 5163 3480 3667 51725 4087 4088 2475 2932 1499 1977 1975 PMC6372777__F2 Figure describes the different effects of gut and brain serotonin on the osteoblast 7166 3358 3351 324 2932 1499 9575 468 595 894 898 PMC6374299__F2 MDSC-dependent promotion of PMN formation and evolution 4318 6279 383 7099 6387 7852 3146 PMC6374618__F4 Schematic relationships between the wound-induced signal transduction mechanisms for the sesquiterpene biosynthesis and regulation in Aquilaria species for the agarwood production 3423 3652 4609 4602 PMC6387036__F2 HBV- and HCC-related genes in L1 biology 5885 7015 1499 PMC6387651__F6 Proposed signaling pathways that regulate LSEC phenotype and crosstalk between LSECs and HSCs in normal and fibrotic liver 948 961 11093 1950 1956 7896 1839 PMC6388721__F3 Simplified illustration of TXNIP role in presumptive pathways involved in endothelial dysfunction 10628 6714 10365 114548 7412 PMC6390240__F4 Modules of core PPI networks of baicalein against HCC 55832 1017 10155 10971 1956 3320 2521 3326 2064 2335 3304 3303 7157 4914 23363 672 4193 983 203068 1915 PMC6396373__F9 Herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐KB signaling and STING's dual role during MCMV infection 115004 29110 3661 PMC6398499__F2 Crosstalk between Wnt, Cdh1, Bmp, TgfB and Fgf signaling pathways in orofacial clefts 655 652 90 6469 999 4487 7040 7042 7043 7049 5083 57822 3664 10253 2260 2263 PMC6404589__F5 Differential regulation of neurotrophin signaling pathway genes 1398 10818 2885 4803 627 572 1610 581 PMC6406015__F1 Regulation of B cell receptor (BCR) signaling on B cell survival 613 973 974 930 6850 695 10125 25780 8915 84433 10892 596 572 2932 10487 10486 331 4170 PMC6406375__F1 Major calcium channels, pumps, exchangers and sensors in mammalian cells 84876 6786 90550 790 759 PMC6407368__F2 Ca2+signaling pathways in Beta-cells 200186 2011 23235 1859 2932 PMC6410766__F8 Signal transduction pathways that mediate migration induced by OA in breast cancer cells 1839 1950 1956 6714 208 PMC6414514__F4 Dynamic mechanism of ADP-ribosylation reversal 2475 11164 8505 53343 131870 28992 PMC6415318__F7 Schematic diagram of molecular mechanisms of Shuangyu Tiaozhi Granule (STG) attenuates hypercholesterolemia in rat fed HC diet 3156 3949 39 1581 64240 64241 PMC6417502__F8 Collagen upregulates MMP-14 through activation of the TGFB/TBRI/Smad3/Snail pathway 6714 1958 1499 PMC6417506__F3 Chemical induction of proximity is sufficient for the regulation of diverse cellular processes 6908 8451 1642 51185 PMC6417835__F4 Roles of FA proteins in replication stress 675 672 545 57697 5888 4361 1763 641 4172 4174 4173 4176 4175 4171 55120 29089 116028 PMC6418414__F1 The wild-type CARD9 protein consists of an N-terminal caspase activation and recruitment domain (CARD) followed by a coiled-coil domain and a C-terminal tail 7124 55223 64170 8161 6850 10892 8915 5971 PMC6420571__F6 Beta-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma 1022 596 2475 142 619501 PMC6423493__F5 GRP78 mediates hypoxia-induced EMT through smad2/3 and SRC/MAPK signaling 6714 4087 4088 999 PMC6425613__F6 Functional enrichment and gene network analysis 6357 5199 1675 966 718 3075 6363 1378 719 712 716 713 369 2335 10818 8835 2255 3598 1270 7010 5008 4982 3575 246330 8672 3559 3554 920 7132 3117 3119 90865 8809 3122 3123 3394 5724 10437 3133 55128 5657 8519 10410 103 10663 715 128486 PMC6426138__F6 Ciliary TGFB/BMP signalling 6608 7046 145508 4092 4089 57154 4087 4086 4090 PMC6430710__F5 Complementary pathways in DNA double strand (ds) break repair and PARP inhibitor response 675 672 5426 5888 142 PMC6431671__F7 Integrative pathway enrichment analysis showing the interaction between predicted and experimental targets 3698 3240 11157 107 7422 3700 1385 710 1938 335 1499 2 7157 207 5004 338 4089 3312 25 462 5265 3273 PMC6433803__F1 Non-canonical NFKB activation pathway 7186 7187 5971 PMC6433964__F3 Repair pathways and signaling in response to DSB induction by IR 472 9156 7518 3981 545 675 5888 PMC6436556__F3 A model showing how the cargo in exosomes can potentially change 1956 11021 9066 PMC6436804__F9 Summary of the toxic mechanisms of ZEA on breast cancer cell growth with antagonistic effects posted by AFB1 6714 5595 6418 5241 PMC6437734__F8 VPA affects IL-12-, IL-15-, and IL-18-mediated IFNG production in NK cells 3717 3718 4615 6775 3458 PMC6438741__F6 At the intersection of DNA damage and immune responses 718 7374 472 200186 PMC6441925__F1 DNA repair pathways with mutated genes highlighted 472 4361 4292 4436 2956 5378 5111 83990 672 5981 675 79728 5914 9156 7516 PMC6442683__F4 Dendritic structural plasticity and neuropsychiatric disease 5066 445347 627 1938 29904 7204 387 2475 PMC6442983__F7 Proposed model for the induction of the Vps34-autophagy pathway in ETV6 RUNX1-positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells 2623 2624 7405 885 PMC6446989__F2 Biliary tract cancers: current knowledge, clinical candidates and future challenges 4975 100187761 2263 4855 4851 4854 4853 1950 1956 3266 673 1499 2475 324 54790 9118 PMC6447179__F7 Traumatic brain injury induces long-lasting changes in immune and regenerative signaling 713 719 717 718 716 3689 715 714 712 1379 722 725 728 1675 710 729 733 PMC6449083__F10 ANAC044/ANAC085-mediated pathway involved in stress-induced G2 arrest 545 472 672 5888 84057 PMC6449224__F4 MicroRNAs regulate the smoking‐related ERBB2 signaling pathway 818 5578 1950 867 7039 367 1398 685 3725 56924 1839 2069 4609 126669 2885 9542 2475 572 145957 10718 PMC6454881__F6 NAD+ regulates T-cell differentiation through a novel MC-dependent signaling pathway 2625 920 7038 100187761 50943 PMC6456305__F6 GPs unmask cryptic variation in parallel signaling pathways and subpathways 27010 3084 7536 PMC6459341__F7 HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1B 3553 5008 6774 3569 3554 PMC6460526__F2 CYLD-associated signaling pathways 1499 4055 51684 8717 7186 1540 23118 10454 5971 5970 1000 3725 6608 PMC6460806__F2 Interactive signaling pathway of EGFR-PI3K-mTOR 1956 5728 5163 6010 6009 5898 5899 PMC6461132__F1 PRR signalling pathways 6850 64127 10392 3654 5336 6102 114548 10454 7187 8915 3661 PMC6466116__F5 Transcriptomic analysis of Fgf10+/− versus control P3 lungs in NOX suggests that reduced Fgf10 expression could lead to vascular defects 2255 4133 5594 1909 2768 6093 2778 4882 4975 3265 1610 5881 4846 572 PMC6468848__F4 Other Notch-related tumorigenic aspects in the pathogenesis of Glioblastoma 2290 7088 54822 79094 1499 6935 3400 6781 PMC6469489__F1 Multiple pathway stimulation of ADAM activity, leading to sAPPA proliferation and notch stimulation 1950 1956 351 PMC6469758__F7 TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro 3661 3553 4615 7099 7097 PMC6470785__F5 Metabolic and signaling pathway crosstalk in tissues of animals with high inherent aerobic capacity (HIAC) and animals with low inherent aerobic capacity (LIAC) 6714 47 6774 2475 2194 581 2321 3480 PMC6471124__F1 The MEK5–extracellular signal-regulated kinase 5 (ERK5) pathway with activators and downstream effectors 983 5371 2309 6774 2932 3553 2247 3091 PMC6471273__F1 Biosynthetic pathway of ginsenosides according to 4598 3652 8213 5925 PMC6472151__F1 The effects of thyroid hormones on the activity and expression level of eNOS in vascular endothelial cells 1734 6955 5266 PMC6473623__F1 Autophagy-A highly conservative cascaded regulatory mechanism upholds the intracellular homeostasis of the biological system 2475 596 9140 83734 9474 10533 3920 3916 55014 55062 64422 4077 8678 PMC6475831__F2 Regulation of intestinal organoid formation by different growth factors 89780 1950 6774 PMC6478283__F13 Identification of key regulatory genes connected to NFKB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network 3558 2263 472 6772 596 572 1956 7412 7374 2353 5971 5966 3726 7124 4791 4790 3727 2056 1386 8027 56914 4018 1950 7099 7173 387 7189 6775 5901 3725 759 2057 PMC6478763__F1 Mechanisms supporting BRAF inhibitor resistance in melanoma 8324 6259 4893 3845 3265 6714 673 207 10000 1846 4286 595 6663 8061 3725 6774 4088 5290 5295 PMC6478827__F6 Cell cycle regulation in GCs of small follicles 4092 2475 4088 894 4609 PMC6479272__F13 Partly hypothetical model describing the characteristic shifts of balance within the sphingomyelin/salvage pathway attributed to immune low and immune high tumor subtypes/subgroups of patients 6609 259230 166929 6610 55512 64781 5168 253782 29956 204219 10715 79603 91012 4099 27163 427 4018 8877 81537 130367 56848 1902 23566 57121 10161 9170 1901 968 9332 929 PMC6479799__F2 Mechanism of CB-R-mediated antitumor activity in breast cancer cells 9290 873 1499 3727 6714 387 2475 PMC6480114__F1 Proposed mechanical cues regulates Hippo signaling pathway in gastric tumorigenesis 6010 4485 57569 9113 26524 9462 1499 999 154796 10413 2638 4609 6714 9411 PMC6481335__F4 Heatmap and expression values of probe sets related to irinotecan metabolism in both liver and tumor 4363 1244 9429 1066 8824 23491 54658 324 PMC6481626__F1 Pathways that influence uracil accumulation in DNA 7374 7298 7083 PMC6481737__F9 Working model of stiffness-dependent calcium response for neutrophils on HUVECs 6714 6850 960 3383 PMC6482478__F1 Basic mechanisms of lithium function 3652 2932 1123 PMC6485421__F1 NFKB and tumor-associated macrophages 4615 3661 3665 383 4843 3627 PMC6485955__F4 FGF21 Signaling Network in Adipocytes 2260 2885 2549 9846 4215 6416 5595 5594 6009 64223 2475 604 200186 56987 11016 4774 4686 9575 7350 26291 PMC6491380__F9 Reversion of HIV-1 latency regulated by DCs 9308 928 1040 977 5163 5728 5266 7248 7249 975 PMC6491625__F5 Network analysis of Ly6D, Ly6E, Ly6K, and Ly6H genes 3458 7422 5465 196 939 916 2355 8061 2353 1385 3725 5915 5914 1879 1051 914 8581 1588 54742 4061 213 83639 29760 3558 406947 919 925 4062 5077 3107 7124 PMC6493202__F6 Neuroprotection by Sildenafil 387 5728 4803 627 PMC6497434__F1 New mechanistic insights into modifiable risk factors that promote pancreatic cancer 6387 7852 6774 PMC6500576__F2 Melanocortin pathway and control of appetite- progress and therapeutic implications 3717 6774 6093 2308 4948 7224 PMC6501144__F2 Angiogenesis signaling pathways induced by oxidative stress 7098 472 7189 7097 10333 4615 PMC6501234__F9 Proposed molecular mechanism for LPS-induced downregulation of StAR expression and progesterone production in pGL 2516 2626 2627 6770 PMC6505469__F10 Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro 468 57761 22926 PMC6505570__F1 Myxoid liposarcoma: it's a hippo's world 4485 9113 26524 10413 5347 2305 PMC6511523__F4 Molecular biological features in the adrenal gland of Hatano rats 5617 4158 3717 PMC6515079__F10 Network analysis of proteome datasets in M2 polarized (vs 4841 966 55502 7532 3190 3921 3312 8570 3858 226 3183 4666 4437 3313 51361 5052 3423 1973 1269 PMC6519375__F7 CLIP‐170 controlling Met RTK recycling in migrating cells 3082 23163 847 PMC6521935__F7 Mechanism of salidroside-induced apoptosis, cell cycle arrest and suppressed invasion of osteosarcoma cells via inhibition of the JAK2/STAT3 signaling pathway 6774 581 595 PMC6523720__F1 Epigenetic mediators involved in the establishment and erasure of histone post-translational modifications and DNA methylation, as described in the text 3065 9759 10013 9734 83933 51564 3066 8841 10014 55869 1431 325 PMC6524193__F5 Functional prediction of key lncRNA-mRNAs network 84343 22808 55744 6921 84809 3135 57876 2521 2027 83440 79877 4853 8454 4088 5467 5601 2650 6482 51006 54507 4588 2683 7284 4522 147111 PMC6524680__F6 PDGF effects in periosteum derived progenitor cells and its interaction with BMP2/Smad signaling 5156 5159 4090 4086 PMC6525811__F1 miR-7 playing a neuroprotective role in PD 5970 9817 114548 PMC6526932__F1 Targeting cancer vulnerabilities with high-dose vitamin C 7018 2539 2597 PMC6528834__F10 DUAL INHIBITION OF ERK1/2 AND AKT PATHWAYS IS REQUIRED TO SUPPRESS THE GROWTH AND SURVIVAL OF ENDOMETRIOTIC CELLS AND LESIONS 2932 596 572 836 PMC6533081__F8 Proposed model of the regulation of erythropoiesis by heme and the HRI-ISR pathway during ID 2056 2887 468 22809 PMC6533250__F7 Wnt/Beta-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast 2932 1499 595 2248 2255 PMC6533683__F10 Regulating EMT by targeting autophagy 4088 1499 3146 3611 PMC6533683__F2 Beclin-1 signaling pathway regulated autophagy and EMT 7471 6935 999 PMC6533683__F3 P53 signaling pathway regulated autophagy and EMT 5728 83734 10533 8408 2475 6935 9839 PMC6534082__F1 The mutIDH1 and mutIDH2 pathways and molecular mechanisms related to oncogenesis 3417 3418 80312 54790 10873 5351 5352 8985 PMC6535662__F1 Various regulatory mechanisms of MALAT1 in different diabetes-related complications 6667 378938 4615 114548 1994 1499 PMC6536593__F5 Implication of hexosamine biosynthetic pathway on the NLRP3 inflammasome 8473 10628 114548 10724 3603 3553 PMC6538535__F3 Menin-associated pathways with potential targeted therapies 2475 1499 6750 3845 6654 8313 3727 1027 1031 10419 2619 4088 PMC6539991__F4 Gene-Pathway network 2534 7422 596 5111 572 991 PMC6540965__F2 Relationship between middle-age obesity, glutamate excitotoxicity and increased risk of Alzheimer’s disease 6774 2475 3717 PMC6542994__F1 Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 7054 978 5465 4922 4149 PMC6548059__F1 Components of the autophagy pathway reported to be deviated in neuropsychiatric disorders 718 10533 64422 PMC6549576__F2 ERK signaling pathway was hyperactivated in the patient's tumor tissue 7535 466 773 1288 27040 3815 1436 4914 2185 2885 5979 5156 5159 3845 780 6714 115 10411 5573 5906 2972 2004 4609 1956 3725 6722 5080 2353 572 2002 3150 5295 PMC6549747__F2 Interaction between tumor microenvironment components, including stromal cells, and tumor cells leads to enhanced cell growth, proliferation, angiogenesis and invasion 8205 1565 595 4609 1576 1577 2521 1021 1019 PMC6550542__F2 Interplay between enteroviruses and the host autophagy pathway 10241 4077 9342 PMC6551881__F8 Over-expression of miR-195-5p blocks the PSAT1-mediated GSK3B/Beta-catenin signaling pathway, thus inhibiting angiogenesis and reducing chemotherapy resistance to DDP 1499 2932 29968 PMC6555789__F9 Summary and integration of the main results 239 247 6536 PMC6556479__F1 MC4R signaling pathway plays a vital role in regulating appetite and energy balance 23237 5443 3952 3953 5122 4160 7840 3358 1363 166379 585 583 27241 129880 79738 55212 582 2778 27125 8660 4159 5367 283455 54551 51715 54760 4808 112609 10743 60675 25970 6197 6492 7068 627 4915 PMC6557086__F6 L-Norvaline, a new therapeutic agent against Alzheimer’s disease 4803 2668 4846 56848 5979 6855 207 2475 PMC6561619__F10 Model of the molecular mechanisms involved in LRRK2 gene silencing in proliferation, migration, and apoptosis in TC cells 120892 581 1019 PMC6562400__F1 Acquisition of cysteine from extracellular cystine through xCT and de novo production of cysteine through the transsulfuration pathway 7295 875 1491 PMC6562634__F1 The Hippo pathway in the pathogenesis of tissue fibrosis 261734 9113 26524 7270 6591 3624 24147 59 3549 4087 4092 2335 PMC6562634__F4 YAP/TAZ-mediated regulatory networks in cancer 8161 6502 6662 595 2305 983 2260 2263 6910 2264 6657 6591 7431 558 5054 11167 9353 6935 1601 7057 22943 PMC6562762__F8 Hypothetical model of Se homeostasis in brain 6414 8991 9403 2879 6415 PMC6563011__F2 Schematic view of PKCA inhibitory activity on the Wnt/Beta-catenin signaling pathway in the normal colon epithelium and in colon cancer 2191 2932 1499 324 5091 PMC6563119__F1 Canonical and alternative Hippo pathways 60485 4485 5911 57826 5912 8491 11183 9448 11184 5871 2308 2309 2152 55233 92597 3661 9113 26524 7003 8463 7004 7005 PMC6566201__F6 Fighting Thyroid Cancer with Microgravity Research 4313 3569 10664 7412 1950 7422 2335 5829 382 5747 5578 7414 5970 8904 5566 3600 5216 7052 6696 3605 8822 6347 3576 3934 2019 PMC6566669__F1 Set of motor neuron proteins in the MAPK signaling pathway 23118 5894 2885 2002 998 3727 4149 6722 PMC6567055__F1 Tumor-associated macrophage (TAM) function in the ovarian cancer tumor microenvironment (TME) and examples of therapeutic strategies 6367 8205 140885 3383 6347 961 6362 3586 PMC6571146__F8 Model depicting the potential involvement of the Mek/ERK1/2-MAPK and the PI3K/Akt/mTOR signaling pathways at different stages of developmental myelination and during adulthood 2475 5163 7249 7248 6009 PMC6572052__F3 Transforming growth factorB (TGFB) signaling pathway with marked expression levels of deregulated genes 4756 148738 4089 25805 3458 7124 8454 6500 64750 4052 2331 6667 387 10468 5308 4838 7046 PMC6580798__F3 Proposed pathway for metabolic detoxication of AAI 1401 1728 1544 1543 PMC6581700__F6 Molecular model for HTLV-1 and HTLV-2 regulatory proteins HBZ and APH-2 on Tax-mediated NFKB activation and TRAF3 interaction 23118 7187 3050 PMC6586788__F1 Hypoxia and aging 2475 4193 1690 PMC6586838__F2 Association between miRNAs of interest and their predicted targets in the insulin signaling pathway (A) and Type II diabetes mellitus pathway (B) 2885 867 1398 407006 355 2308 3643 3630 5163 5164 2932 7249 7248 6009 572 2475 1977 2002 389692 PMC6592760__F2 Metabolic regulation of cell growth and proliferation 468 4553 440 26227 29968 6009 PMC6593294__F1 Possible pathways underlying the DLL1/Notch signaling pathway defect 6868 22938 100 4087 4086 102 468 6469 860 23462 28514 4851 9794 PMC6598280__F2 Paracrine effects of the ASC secretome and involved pathways 3558 1401 80310 3479 PMC6600639__F1 Upon T-cell receptor (TCR) signaling, the protein arginine methyltransferase PRMT5 interacts with DUSP14 and induces its methylation on Arg17, Arg38, and Arg45 residues 10454 11072 7186 10419 PMC6600670__F8 Mechanism by which EPD attenuates IMQ-induced psoriasis by inhibiting the inflammation responses via TLR7/8–MyD88–NFKB–NLRP3 inflammasome signaling pathways 51311 51284 4615 7189 114548 PMC6600680__F7 Mitochondria-mediated apoptotic signaling pathway by JNK and p38 836 572 842 331 581 27429 PMC6601021__F1 Activation of the UPR pathway in tumor cells 83939 51493 468 PMC6604204__F11 Schematic model of how minocycline may inhibit TNF-Alpha-induced cell fusion 6714 4318 4314 3383 PMC6605043__F1 Probable mechanisms of the effects produced by lncRNAs on TBI.Notes: There are several lncRNAs that have been reported to play different roles in the process of TBI 60674 378938 283131 100616245 283120 23642 PMC6605314__F10 Schematic model of GPCR-mediated gene expression in neurons 23373 627 1847 23237 1959 PMC6610339__F1 Release of mitochondrial proteins and mtDNA initiates an inflammatory response in CICD 114548 54106 115004 3661 581 PMC6614068__F6 Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy 1072 10381 4099 PMC6614686__F5 Pathway Map of Glioblastoma obtained from Wikipathways using Cytoscape 1956 406991 2064 2263 4018 3480 3667 6714 54206 5728 2549 2885 867 4763 1636 10253 5335 4303 369 5336 673 1027 7248 7249 1026 5583 5584 5580 5590 5606 2033 595 6416 1030 894 472 1021 5925 672 695 5156 2308 1017 5579 5607 PMC6617704__F7 Illustration of IPO5 involvement in CRC 9462 3843 596 581 1021 1019 595 PMC6618483__F8 Model describing Etv4 and Etv5 induction following distal NGF stimulation 4803 2118 2119 6722 PMC6621453__F3 siRNA screening identifies TrkB, TrkC, and FGFR1 2260 1859 7016 208 2475 PMC6624780__F9 TSL suppresses angiogenesis by inhibiting the VEGFR2 signaling pathway 790953 1019 4318 4313 PMC6625878__F1 Schematic figure summarizing the HIF pathway and the transcriptional regulation by HIF of genes related to angiogenesis, metabolism, survival/proliferation, metastasis, stemness, and the ECM 7428 5228 284 2248 7422 3098 5230 5315 3939 5211 3481 901 2056 133 7039 4851 7852 960 79923 9429 PMC6627782__F3 mTOR signaling in spermatozoa from older men 207 84335 5599 64223 64798 6198 6194 PMC6636231__F2 Proposed working model of RGS proteins in the regulation of the Ca2+ oscillation-NFATc1 signal pathway for osteoclast (OC) differentiation 10326 126014 6002 6001 4772 100187907 PMC6636296__F2 Network of Wnt signaling regulates tumor metabolism reprogramming 324 2475 7249 7248 1499 4609 PMC6637138__F7 Innate immune response activation in BRCA2-deficient cells 3454 3455 6772 6773 3661 115004 675 PMC6639367__F1 Cellular glycolysis and oxidative phosphorylation 5209 2147 26136 PMC6642550__F9 Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation 4922 3258 3553 3606 PMC6643109__F3 In T2 DM rats, where the Hepatic Glucokinase (HGK) is lower, the level of lncRNA NONRATT021972 is increased 207 2932 471 PMC6647228__F2 Schematic presentation depicting the energy metabolic pathways through which AMPK controls the activation of MDSCs 948 6774 4780 2475 PMC6650903__F4 Schematic plot of significantly differentially expressed genes involved in GA metabolism and signaling under CK, CCC, and PBZ treatments in roots and shoots 340451 8139 80119 1356 PMC6651255__F2 STNM01 blocks the glycosaminoglycan synthesis pathway through RNA-induced silencing complex (RISC) activation 1431 51083 51363 PMC6651320__F1 Schematic representation of MVA pathway 3156 6713 1718 1717 PMC6651655__F3 Representation of S100B effects on Caco-2 cells 6285 2475 8178 PMC6653007__F1 Ferroptosis induction 2805 6774 80221 1431 2879 79094 468 8678 23657 6520 7417 PMC6667461__F1 Overview of direct and indirect pro-allergenic immune responses to anti-ulcer drugs (AUD) 325 3569 7097 7054 196 2444 PMC6668984__F6 KEGG pathway enrichment analysis in signalling pathways 6772 5894 6714 207 4790 409 8480 5580 PMC6672053__F4 Cellular response to T–R conflicts 545 2177 57697 675 672 PMC6677151__F6 The inhibitory effect of Gal-3BP on TAK1-dependent NFKB signaling pathway 3553 7099 4615 8717 7186 3654 51135 7189 23118 257397 3959 10454 PMC6678087__F3 Representation of the two serrated pathways 673 3845 3240 4255 4292 3081 PMC6678477__F1 Rac1 activation is regulated by GEFs and GAP 7074 6654 7410 5879 PMC6679095__F2 The PI3K/AKT/mTOR/NFKB Pathway 8821 5728 5163 7248 64223 7249 2475 64798 253260 6009 PMC6679869__F1 The role of inflammasomes in lupus nephritis 3466 7099 51311 140609 9447 3428 PMC6684943__F1 Regulation of C/EBPB in MDSCs 7939 1051 383 4513 4843 PMC6685594__F4 lncRNAs mediate drug and radiation resistance 100124700 55384 378938 652995 8408 60674 5820 1956 7039 1786 100885775 581 1499 6774 3198 3480 6662 4170 2475 PMC6687721__F7 The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress 83939 581 468 842 836 PMC6688195__F1 Key intrinsic immune evasion mechanisms exploited by HPV oncoproteins in keratinocytes (KCs) 2146 10873 3065 7187 7345 1786 9547 6773 6772 115004 10379 912 6890 54106 PMC6688483__F4 Role of CRPs in AIBD 1828 1830 718 1604 PMC6689672__F3 Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung 58191 6364 10563 2833 978 260431 929 196 2625 945 3684 2526 7852 643 7054 PMC6691199__F3 Proposed pathophysiological mechanisms that could explain the presence or absence of response to treatment in myocarditis 9531 1832 6262 3553 5318 PMC6694157__F5 P53 signaling pathway (hsa04115) is extended in the weighted network 3623 81888 9538 5210 23287 646 1409 6419 6477 6494 9874 581 54205 637 51550 90007 55230 5066 596 9191 545 2810 115426 4616 5473 11126 1613 55179 389434 6768 9978 4193 23253 22836 7161 1511 8626 5429 3827 7593 152006 8493 50808 8567 259266 3483 51390 6903 65991 7727 3664 79841 56475 9609 5004 84265 5054 3109 84283 3732 5728 472 5805 10983 8231 84561 3818 23221 29957 252839 3112 PMC6694749__F5 PIKKs-related signaling pathway in the aging brain 6741 23300 472 545 9656 672 4899 PMC6695833__F2 Transcriptional co-ordination between YAP1/Hippo and p53 family proteins in tumorigenesis or apoptosis 4193 10413 983 891 5784 5371 86 63970 23286 581 PMC6697716__F6 Putative signalling pathway of Ctyl1 54360 729230 6662 PMC6697957__F3 Wnt signaling: a promising target for osteoarthritis therapy 309 650 6608 4090 4086 1499 6662 3280 860 4040 4041 PMC6700399__F1 Inflammatory pathway centered upon TNF in the process of NASH-HCC development 619501 6098 7124 7099 6772 6774 PMC6704159__F7 The cooperation between M and P proteins to inhibit different Jak-Stat-pathway steps 3466 3716 6772 9636 7297 PMC6704489__F3 Gene category of the NFKB signaling pathway 3932 5335 27040 472 29760 6850 4067 613 638 7189 331 8717 7186 23321 3553 3929 929 114609 695 1270 4284 4803 7187 4049 4050 1610 6737 920 4055 PMC6705791__F5 Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study 6342 5106 6762 345 6257 2181 2170 3158 6319 133 8309 1622 1962 PMC6705791__F6 Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study 6891 3122 972 3112 5720 6892 3310 2923 10197 7263 3135 5721 3107 1508 3126 2 3106 3133 567 PMC6713350__F5 Bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells 963 57572 81606 5331 6778 7423 22904 4046 177 10095 2149 11314 7252 652 8751 7098 972 6591 5054 5580 5914 412 1021 3371 558 10417 83931 2719 9448 4256 197259 1893 57124 8859 5128 22795 50964 6443 8828 9133 4638 6387 PMC6713396__F4 Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India 196 7124 2100 2099 57491 405 8202 10499 7025 8431 135112 4763 4738 8473 355 581 1544 PMC6714138__F8 Schematic diagram showing the cardioprotective effects of YWPC on DOX‐induced cardiotoxicity 9817 1728 2730 847 7040 4088 596 PMC6714236__F7 A schematic model depicting the functions of SNAI3‐AS1 in HCC 4087 4088 197187 5976 4092 619501 PMC6715281__F1 Wnt signaling pathways and the regulation by Wnt antagonists and the bone microenvironment 50964 4040 4041 4920 6259 324 7428 85451 7502 3091 PMC6715306__F1 Extrinsic and intrinsic cues regulate the oligodendrocyte program 5728 2475 3084 3479 4155 6663 7528 116448 2534 6010 627 6925 6469 5156 3398 388585 6660 3400 PMC6716635__F3 Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance 1869 217 1158 335 1490 488 23493 7421 3759 1827 59272 3762 4879 4883 5894 2305 4634 604 7060 6548 PMC6718556__F5 Several metabolic mechanisms may provide an advantage to Tregs in the tumor microenvironment 2645 355 948 PMC6720817__F3 Intracellular signaling involved in cardioprotective response stimulated by ischemic preconditioning (PreC) in cardiac cells 6714 1956 2932 572 581 PMC6720817__F4 Intracellular signaling involved in cardioprotective response stimulated by ischemic postconditioning (PostC) in cardiac cells 2932 572 581 PMC6721055__F3 SUMOylation regulates gene expression during Acute Myeloid Leukemia (AML) response to chemo- and differentiation therapies 10055 1649 7018 PMC6721562__F3 Direct and indirect epigenetic control of cellular metabolism 3091 3099 2475 7428 2203 5728 PMC6721565__F1 Canonical WNT signaling 4040 4041 54894 55366 8549 59352 1499 324 PMC6721734__F6 Molecular interplay between estrogen, EGF, and Notch signaling pathways in FTEC ciliogenesis 28514 2302 1956 1950 PMC6723309__F2 Hypothetical model for adenoviral regulation of stress-induced EGFR signaling through NFKB 1956 7251 5300 83547 PMC6727394__F1 Altered metabolic pathways and associated circRNAs in cancer 2194 619501 2744 2746 3939 95 PMC6727394__F2 circRNAs and the Warburg effect associated signaling pathways 7422 3480 324 6774 2638 1499 596 2475 PMC6731550__F4 Intracellular pathways targeted by disease pathogenesis in FTLD 203228 8878 55255 29978 140775 10133 7415 PMC6733901__F2 Pyroptosis in cancer: pro-cancer or pro-“host”? 22861 4671 114548 9447 8772 58484 79792 1687 3553 PMC6736563__F1 DSB repair pathways 5888 142 10721 3981 PMC6736567__F1 Canonical Hh signaling 5091 6608 51684 156 2736 83737 894 PMC6736714__F8 Gli phosphorylation code 6608 51684 25989 27148 PMC6738443__F4 Modular network regulation map of gene-related ncRNA/TFs 7018 7454 8740 7097 3949 3569 3383 1508 55000 1374 958 581 351 6868 2180 468 6955 5978 5465 2521 5970 114034 643911 4311 8190 4284 60672 8178 PMC6740038__F1 The dual roles of Keap1-Nrf2 signaling pathway in pancreatic cancer 9978 8452 9817 PMC6740038__F3 The Keap1-Nrf2 signaling pathway 9978 8452 2932 9817 6500 PMC6740038__F4 Targeting Keap1-Nrf2 signaling pathway for pancreatic cancer prevention and therapy 9978 8452 1356 2932 9817 6500 PMC6741895__F7 The FA pathways involved in ABeta-induced neuronal dystrophy 867 2534 1020 2932 351 PMC6742404__F1 Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison 7462 1734 1735 687 7067 4155 7068 4336 PMC6743121__F8 Schematic depicting HSPA5 protects against DHA-induced ferroptosis in glioma cells 1998 83939 468 2879 3309 PMC6743792__F7 Executable pathway analysis using ensemble discrete-state modeling for large-scale data 5578 7791 3678 7059 7094 87 394 7408 3676 7414 3672 824 64098 81 2335 23396 2317 3655 1729 3688 5829 8515 673 2909 5501 2316 387 5906 3695 2889 5908 5499 6093 5747 5579 60 2064 9475 3685 1398 1399 4659 998 5500 6464 3611 71 2932 4660 7423 2534 208 340156 10627 10000 5155 2321 207 3480 1499 3725 5058 5290 894 896 5291 5062 329 5880 2885 2002 7409 4638 5295 330 331 6655 5296 8503 5293 5594 596 5601 5595 572 6654 5879 5599 5604 10451 103910 5170 5894 55364 5266 PMC6744391__F9 TAAR1 signaling pathway/apoptotic pathway components 134864 5163 581 PMC6747293__F1 Stress-induced senescence 472 545 1019 1021 1017 1033 PMC6747541__F3 Syntenin-mediated signaling in the regulation of membrane structure and cell motility 923 214 6714 4313 387 998 967 PMC6751247__F7 Schematic description of TLR7-mediated enhancement of CD8+ T cell function 940 51284 207 4615 2475 3662 3458 PMC6755513__F10 Schematic chart showing the molecular pathway for Mg2+‐regulated endothelial barrier function 54822 140803 84061 PMC6755804__F4 Selection of enriched pathways and genes and their involvement in various tumorigenic pathways 5468 11186 6608 9978 5465 2114 1326 2625 9770 5903 55717 10735 3096 5654 27250 79710 283120 1755 55384 29948 140690 84133 2475 2919 4804 4803 2950 1832 56475 3595 2232 5900 23401 3918 9547 9321 3955 9249 254065 51309 8861 8019 7074 5660 5727 6304 5307 7015 8204 11064 1299 5033 2354 4312 4303 50859 9510 1301 4886 6010 7075 50649 151871 57402 972 1956 PMC6755804__F5 Network of pathways and genes induced by P152Lp53 expression 10266 6010 2475 5660 23401 85319 4803 115727 1956 2804 PMC6757285__F1 Glutamine-dependent regulation of BMSC osteogenic and adipocyte differentiation 2744 2475 51280 PMC6757413__F4 Important signaling pathways that govern the differentiation of pancreatic conversion and the mechanism of action of different small molecules and peptides reported on pancreatic differentiation from MSC 3082 4838 2549 1499 351 324 1950 1956 2475 PMC6757435__F9 Signaling pathway proposed in this study 7074 5879 7286 331 PMC6759579__F5 Functional overview of the embryonic complement system 718 1191 717 1604 966 721 716 715 2271 4179 1378 708 811 1380 PMC6759650__F5 Enrichment in multiple cancer-associated networks in breast cancer 3880 29089 3875 3150 5979 7031 22941 57758 7022 7494 29028 25987 9687 2099 1952 3169 23242 79170 2288 342184 6542 4435 23508 79682 80139 57678 5570 22926 PMC6761256__F10 Putative mechanism of necroptosis and relative inflammatory responses during the development of CCI 3146 197259 114548 3553 7128 PMC6764206__F4 Biosynthetic pathway of plasmalogens and diacyl phospholipids 3098 2821 8760 283871 5833 10390 716 10400 5091 23761 55512 PMC6766413__F4 μOR regulation of CXCR4 working modelMorphine or other μ-opioids binding to μORs on cortical neurons activates a GAi-protein pathway that leads to de-acidification of endolysosomes, and efflux of endolysosomal iron to the cytoplasm 6387 7852 9759 5879 5058 3984 PMC6766623__F12 Molecular mechanisms by which pretreatment with monophosphoryl lipid A (MPLA) suppresses LPS signaling in the medullary thick ascending limb 7099 7097 4615 3654 54472 PMC6767293__F3 The effect of corilagin on the Notch-mTOR signaling pathway in cholangiocarcinoma 2475 4851 9794 3280 PMC6770018__F6 The key carbohydrate metabolic pathway and the miRNA–mRNA interactions in dmc 2875 2695 11181 PMC6770077__F1 Pathway shows the influence of adipocytes on cancer 3569 3479 1317 3570 3953 3643 51094 79602 3667 4513 2475 PMC6770240__F1 Overview of an acute myeloid leukemia cell’s metabolism 3417 2744 3418 PMC6770250__F2 TGFB signaling in cholangiocarcinoma (CCA) progression 4087 4088 205 PMC6770306__F2 DNA damage response network in SCLC cells 84126 545 472 5885 672 5888 79728 7518 286257 PMC6770807__F6 Proposed action mechanism of 6SL 1021 1869 5111 367 PMC6770861__F6 A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability 581 891 4318 5347 PMC6771394__F6 Allelic origins of the carotenoid pathway genes 1674 8168 2353 4397 7054 PMC6771966__F1 Mutual interactions of the mitochondrial compartment with hepatitis viruses and the consequences on the infections 3458 57506 29110 115004 3661 3665 PMC6775198__F2 Immune exclusion through the Wnt/beta-catenin pathway 8205 1499 50943 3553 6351 3569 PMC6776190__F10 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs 2619 6608 7546 51715 2932 PMC6783844__F1 The illustration of human IgG1 structure with N-glycan attached at Asn297 site in the CH2 of the Fc region 1431 51083 718 PMC6788756__F2 Functions of the calcineurin signaling pathway in S 759 1255 6492 6493 5954 9776 10413 2877 5955 3280 51028 1373 4281 PMC6789187__F2 Citrate produced through mitochondrial metabolism can enter the fatty acid synthesis pathway 4018 355 6319 47 847 3156 4513 4512 717 PMC6789757__F5 Mitogen-activated protein kinase (MAPK) signaling pathway and related miRNAs 1610 8168 4351 6722 2316 8717 7186 4149 355 929 4201 51701 5972 4352 PMC6794370__F7 Mitochondrial dynamics in cancer 4976 55669 54471 56947 51024 125170 9927 PMC6794807__F5 Protein-Protein interaction network and 5 identified sub-networks of TTR-mRNAs 11064 259266 28755 3034 10923 23178 5447 440 10612 27429 26256 5478 2669 103 27349 4286 5970 23107 2717 367 1191 133 1690 29940 49856 9696 6955 9924 4047 84890 8567 PMC6795182__F1 Cluster-1, cluster-2, and cluster-3, with molecular-targeted therapeutic options 1956 1950 55534 4763 4191 3667 1499 2271 7812 7249 7248 4149 112398 54583 55654 7428 3065 PMC6798084__F1 Nicotinamide adenine dinucleotide (NAD+) metabolism in plant cells 2597 5829 65220 PMC6798356__F2 COPD creates a favourable microenvironment for lung cancer initiation and progression 7124 999 6275 6418 260431 PMC6800142__F7 TGFB receptors activate Smad signaling and non-Smad signal transduction pathways 7189 4087 4088 4089 PMC6801762__F1 Schematic presentation of the metabolic pathway and transporters that regulate the cellular polyamine levels 6582 6580 6581 54498 196743 6303 6520 84561 PMC6803569__F4 PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules 2146 3099 5820 3939 7291 1019 581 596 PMC6810715__F2 Clinical and Molecular Phenotyping in Scleromyxedema Pre- and Post-Treatment with Intravenous Immunoglobulin 998 4092 7040 7043 6885 11184 7189 10454 7042 57154 6416 4838 4087 4088 64750 54778 6497 2885 56937 4089 145258 3725 7050 8928 3065 51588 5054 596 655 3172 7421 7030 5894 4133 5604 4086 3665 268 2353 4091 3196 4090 23090 3225 860 5308 1482 PMC6812587__F2 Macrophage function by polyamine synthesis 4843 383 384 6723 54498 6611 9474 PMC6813288__F3 Mechanism of NFKB activation by PA 7099 7189 2932 83939 PMC6817417__F1 PI3K/Akt signaling pathway regulated by PTEN 5728 2475 4193 PMC6817752__F11 Schematic showing the proposed mechanism of action and regulation of HNRNPK/miR-7 9314 3416 3643 8660 9619 6667 3190 PMC6822471__F4 Docosahexaenoic acid (DHA) signaling pathway detected by GSEA 5163 5287 2931 572 598 596 638 637 581 54205 PMC6823243__F2 SHP-2-mediated activation of ERK 2885 55824 6714 PMC6823243__F3 SHP-2 in cytokine receptor signaling 5266 5163 2885 2475 PMC6823248__F5 HDAC6 inhibition repressed B cell signaling pathways in NZB/NZW mice 3565 958 7099 4064 2534 640 4067 29760 5728 8915 27071 3566 975 3725 2353 2002 1385 PMC6825561__F1 Proposed scenario of current strategies targeting different traits of dysfunctional mitochondria in Alzheimer disease (AD), including mitochondrial bioenergetics and mitochondrial homeostasis 351 8408 9706 2475 23411 7019 4899 PMC6826537__F1 Pathways controlling the epithelial-mesenchymal transition (EMT) program in prostate cancer (PC) 4088 4087 999 2932 3280 54626 23462 100188776 1499 1000 2191 PMC6826985__F7 Gene activities in the TGF beta signaling pathway 25805 4089 3458 4091 4092 8454 6500 4609 7046 4087 4088 1616 387 10468 5308 4838 PMC6829226__F4 LncRNAs regulate EMT signaling pathways 324 2932 4087 100505633 100127888 652995 100505994 100124700 221718 10230 378938 282 1499 4089 112597 4088 6615 6591 9839 6935 PMC6829479__F1 Effect of pharmacological and transcriptional inhibition of lysine-specific demethylase 1 (LSD1) on induction of the cell cycle and DNA damage response (DDR) pathway in microvascular endothelial cells (HMEC-1) 8900 9133 898 84126 5111 PMC6829497__F1 Canonical Wnt ligands induce two mutually exclusive Dvl2- and Fyn-dependent arms 6714 89780 6774 4040 4041 PMC6830879__F4 Schematic diagram showing the major regulatory growth factors released by exosomes and the changes in tendon that occur aiding the healing process 2475 7474 81029 4087 6778 8877 51129 PMC6830904__F1 Intracellular NAD metabolism 64802 349565 23057 203447 952 10135 4837 316 PMC6831866__F20 Continuation of the processes described in A 4025 581 836 842 PMC6832112__F1 RTK and nRTK networks in H 1956 4318 4313 102 2885 2549 6774 PMC6832198__F4 Intracellular molecular alterations and their effects on tumour microenvironment immune activity 3815 5728 2475 8205 PMC6834162__F2 Methotrexate (MTX) transporters, metabolic pathways and intracellular enzyme targets 5981 2356 8836 1719 7298 4524 471 4397 PMC6836113__F10 Continuous impaired insulin signalling causes the activation of AD markers (GSK3B and TAU genes), thus increasing the amyloid beta aggregations leading to AD 2932 5212 5163 PMC6838672__F3 High-Throughput Assessment of Kinome-wide Activation States 673 51701 1025 5311 998 4094 1119 PMC6851521__F2 The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism 55384 728655 5728 64422 1499 2475 PMC6852943__F2 Inhibitory effect of miRNAs on their target molecules in the UPS pathway 9099 8975 442891 7320 7334 7337 331 574456 8535 574506 7319 7329 PMC6854009__F5 Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Vaccinated Subjects (–) 5091 1610 8178 613 1540 10913 7124 4803 1270 1950 920 PMC6857111__F5 Coexpression network was constructed by WGCNA 6241 367 9522 168667 6502 1611 7054 6622 4084 729540 400966 100381270 9774 56664 23271 55915 29092 25957 6723 133746 9765 5903 54165 9541 9988 9736 9648 100313938 677679 100129405 2499 100126299 2498 501 677820 692205 7151 647033 9277 5473 25836 3702 727851 5901 PMC6858307__F1 MDC1 loss causes greater IR sensitivity than H2AX loss 10111 472 9656 3014 9025 165918 PMC6858516__F4 Towards precision oncology in advanced prostate cancer 51755 4436 2956 472 545 4292 5395 11200 675 672 PMC6859487__F1 Basic metabolic pathways used in T cells 2475 2597 948 847 51660 25874 PMC6859529__F7 Redox regulation of IRE1A to control UPR 10130 7186 7494 PMC6860913__F3 TLR9 has been proposed to signal through two independent cascades, (A) the canonical inflammatory pathway and (B) the non-canonical stress tolerance pathway 4615 54106 3665 7189 PMC6862015__F5 Complement lectin pathway activation 213 730 966 731 325 10747 7448 2160 1401 2219 717 1634 1991 3075 725 5340 7295 2159 811 2244 2243 5627 914 2162 1431 4036 7097 4179 3426 2266 3078 409 7454 5578 5566 PMC6862444__F2 GBM induction of PD-L1 secretion 2475 7425 1956 7189 6772 4615 5728 3459 3460 PMC6862705__F5 SPRY-altered signaling network profiles in mammary stromal fibroblasts 1956 2064 1398 5747 5529 23035 6714 27 5062 5829 7249 6416 3611 5605 7414 387 5601 5599 200576 1978 6194 3725 PMC6863766__F5 Metabolomics study of fasudil on cisplatin-induced kidney injury 355 65057 3492 PMC6874443__F5 Functional enrichment analysis and construction of PPI network 27240 5778 11184 84174 64333 53347 147138 399 915 919 55423 916 3561 11151 3932 80342 914 22806 54440 3683 114836 3594 374403 9051 10538 1234 2672 201633 8320 942 939 2833 PMC6876280__F1 An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer 23512 2146 8726 22823 PMC6876298__F2 Dysregulation of the complement cascade in C3 glomerulopathy 718 727 1431 716 4179 720 721 1380 1378 966 2271 PMC6876670__F3 WNT/Beta-catenin, TGFB1, PI3K-AKT, SMAD, and PPARG pathways 22943 4040 4041 5728 324 1499 595 PMC6876670__F6 Canonical WNT/Beta-catenin pathway, Warburg glycolysis, and cancer 4040 4041 22943 3939 324 5728 1499 2932 PMC6880611__F1 Insulin signaling and insulin resistance in MetS and skin diseases 2885 5163 7249 2002 PMC6884041__F1 Neutrophil immunometabolism in cystic fibrosis 7097 6667 114548 3553 PMC6885218__F1 MTOR signaling pathway is involved in liver IR injury and plays crucial roles in autophagy 472 5728 7249 2475 253260 9776 22863 7030 7942 29982 60673 PMC6888549__F1 Wnt signaling pathways 50964 324 1499 4040 4041 PMC6888566__F4 Roles of non-canonical Wnt pathways in osteoclast differentiation and function 7474 4920 23500 6010 3725 6667 29941 51384 54361 4772 100187907 81501 PMC6888741__F3 Hippo signaling pathway 4771 6010 4485 60485 9113 26524 5784 374 27063 PMC6890664__F4 Altered cancer pathways in ASL, CCA and HCC 2335 6010 10155 2316 472 7531 85464 7431 2253 2255 1950 2308 7273 79184 1499 7046 238 2778 2771 8295 5584 4621 46 PMC6891791__F5 Nervous system pathways in KEGG pathway analysis 9261 4915 3725 581 5970 3667 4792 351 1386 2353 43 PMC6893734__F6 Schematic representation of the regulation of the autophagy-lysosome system in response to severe energy deficit and its modulation by exercise 1519 1738 8408 596 79868 10533 55626 9474 9140 PMC6895267__F9 The proposed working model 142 22880 55226 7515 55743 PMC6895847__F2 The unfolded protein response (UPR) and its connection to cell death 8772 7186 83939 468 PMC6901085__F1 Representation of AKT pathway and downstream effectors 3667 2885 9846 6009 2475 117145 64223 253260 55615 5163 7248 7249 4193 5728 572 1977 27250 595 581 PMC6902900__F2 Overview of cellular metabolism in T cells 5163 2645 7249 7248 355 64798 1376 2308 2309 1493 4609 50943 PMC6904751__F7 TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKB/VPS34 pathway 8408 26100 7942 PMC6906145__F1 Regulatory pathways for Arid5a under TLR4 signaling 7099 10865 11059 6774 PMC6906418__F1 Intracellular sensing of viral genomes and viral evasion 7706 89122 84282 7323 9958 10475 55601 10013 7375 6775 55294 6741 10146 85364 1656 54941 79845 9960 27005 1540 9097 63891 84166 135644 1612 126364 54505 8780 201292 10206 91947 221079 7187 57506 3661 3665 51320 29110 4703 PMC6908429__F4 Tetherin blocks virus release, activates an innate immune response and is counteracted by Vpu or Nef 6850 7186 7189 3627 PMC6910929__F3 Regulation of PI3K/AKT signaling pathways 406 5728 5163 2580 572 PMC6911354__F1 MYC as master regulator of proliferative lipid metabolic pathways: fatty acid synthesis, fatty acid elongation, and glycerophospholipid synthesis 4397 2194 47 31 355 6319 4609 79071 54898 4018 10554 1040 PMC6912224__F2 SMAD- and Non-SMAD-dependent TGFB signaling 1893 6010 2475 7018 7939 PMC6912660__F1 The main estrogen receptors signaling pathways: in the genomic pathway, classic estrogen receptors (ER A and B) act as transcription factors upon homo- or heterodimers 1950 6654 673 PMC6913740__F7 Carbohydrate metabolic pathway in ‘outer tissues', endosperm, and embryo of a barley grain and the differential transcript expression of involved genes in 18-6 transgenic grain from 7 to 24 DAP 1611 7431 6697 106049960 PMC6915012__F7 Schematic representation of the PAME-induced G2/M arrest in hBM-MSCs 4193 207 983 PMC6915017__F6 CD28 regulates blast thoracic exposure-induced oxidative stress and apoptosis in brain tissue in mice via the PI3K/Nrf2/Keap1 signal pathway 3553 940 6647 PMC6915081__F7 The possible mechanism of sotetsuflavone inhibited progression of non-small cell lung cancer 581 2475 9474 10533 PMC6916202__F12 Major receptors and signaling pathways/proteins involved in atrophy and hypertrophy 3479 3480 3667 7186 7187 51725 4088 4087 2475 6774 2932 2152 9759 PMC6923165__F3 Time-dependent changes of gene expression of the KRAS signaling pathway after treatment of PDAC model cell lines differing by the KRAS mutation status with paclitaxel in vitro 3845 5266 5747 5294 2185 5578 673 5170 5879 369 5728 5894 9610 5900 207 208 5898 2932 5058 387 10928 2475 8569 2872 5609 5290 5604 5605 PMC6923180__F6 Schematic diagram of the pathway for OXT inhibition of CRC metastasis 5020 5021 6347 PMC6923932__F4 The molecular network of differentially expressed proteins in CAVD generated by Ingenuity Pathway Analysis 79798 131890 55351 83694 340156 166614 7625 5681 80216 3320 55632 7762 23617 3326 3645 386617 140469 2923 83479 9889 3569 7124 3956 302 735 6876 1431 PMC6925521__F1 NHEJ occurs at all stages of the cell cycle 3630 3622 165918 672 580 3981 5888 PMC6927425__F2 Non canonical Wnt signaling 4920 387 998 PMC6927425__F4 Targeting Wnt signaling to combat cancer 324 847 1499 PMC6927537__F2 Kinase alterations and signaling pathways dysregulated in Ph-like ALL 2056 2322 3717 3718 4893 3560 5447 64109 3630 3716 3845 1436 4067 2260 7297 25 27 5156 5159 4916 2475 1399 7750 2120 PMC6928850__F1 Molecular Characterization of XX Maleness 2018 2626 717 56956 7490 7536 6495 51804 3480 6943 3643 1499 6736 668 10468 54361 284654 6662 2254 6658 30812 9580 6663 1761 6770 1717 5447 268 367 269 PMC6928935__F1 The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway 5163 2475 64798 253260 2000 PMC6932173__F6 Proposed inositol-requiring protein 1 alpha (IRE1A)-dependent mechanism of type I interferon induction upon proteasome impairment 83939 7187 3661 3665 7939 PMC6932917__F10 RXFP3 in DNA damage response and repair 117579 3014 472 142 51289 672 9815 9656 4361 5591 675 5888 PMC6937654__F1 miRNAs regulate the HSC activation and schistosomiasis liver fibrosis through modulating TGFB/SMAD signaling pathway 7040 4092 4087 4088 7421 1281 4089 PMC6938582__F2 Action of metformin in endocrine tumors: metformin is a negatively charged molecule that enters the cell through organic cation transporters (OCTs) 3479 6774 3667 2475 1956 467 7248 7249 595 PMC6938671__F1 Two predominant DSB repair pathways in mammalian cells 11284 7518 3981 672 1763 641 7486 9156 5893 5888 675 7156 116028 146956 80198 84464 348654 PMC6944215__F5 Representation of the adverse outcome pathway (AOP) network involving BPF 595 1019 2852 1021 PMC6945783__F1 Scheme of the functional patterns within the glycolytic pathway in beta cells in health and type 1 diabetes 2645 3098 5209 3939 5163 PMC6947309__F1 Stimulation of a particular TLR by DAMPs and activation of the IL-1 pathway via stimulation of IL-1R 4615 7189 51135 PMC6947352__F11 Cell cycle pathway 9126 4089 9184 5111 1017 1022 6502 10926 23595 PMC6947643__F2 The gamma secretase (Gamma-secretase) complex: It is comprised of presenilin enhancer (PEN-2), anterior pharynx-defective 1 (APH1) and nicastrin 102 6868 3280 23462 999 PMC6952906__F2 Schemes of feedforward loops (FFLs) 7018 1958 5468 1869 10067 5925 3569 PMC6953055__F1 HBx-dysregulated miRNA in the P13K/MAPK liver cancer pathway 1906 3082 5728 9759 2475 PMC6958404__F1 Major Signalling Pathways Involved in Hepcidin Regulation 654 2056 148738 57045 9518 151176 164656 5447 3077 3716 3717 7036 4091 25805 4090 4086 6774 4092 4089 PMC6959318__F7 Model illustrating possible functions of DGAT1 and DGAT2 in human skeletal muscle cells 355 8694 4099 84649 PMC6961113__F1 B-vitamins, one carbon metabolism and related pathways 867 6470 4548 4552 4524 875 1491 PMC6964037__F4 Functional network analysis of I-MDSCs in CRC microenvironment 2885 6774 2002 6722 51701 147111 324 11197 50964 6500 8454 2040 387 27130 6259 PMC6966863__F7 Mechanism for ABC transporters regulated by the level of PI3K 110A or 110B subunit 5163 5164 572 7249 2475 PMC6968989__F2 Genetic pathways effected by mutations in maxillofacial bone tumours 324 4193 2778 2260 3845 59341 4763 1499 673 PMC6970510__F2 Different regulation of PAQR3 on multiple signaling pathways.Notes: Reproduced from Zhao Z, Chen Y 5929 7291 8945 1643 152559 22863 22937 PMC6975143__F1 Unfolded protein response (UPR).Under normal conditions PERK, IRE1, and ATF6A are sequestered in an inactive state in the ER via their associations with BiP 22926 83939 7494 468 PMC6980368__F2 S1P signaling in HCC progression 124976 3082 1901 4316 7186 8678 999 PMC6984609__F1 Role of autophagy in the maintenance of intestinal homeostasis and potential mechanisms by which defective autophagy may contribute to CD development 9075 7097 64127 7939 3586 4170 596 2932 50943 920 7124 3569 442911 440275 114548 834 23581 3606 3603 2475 3553 345611 836 1147 120892 8767 7099 114609 5862 3661 26191 5771 10133 2081 4037 50616 3456 PMC6986015__F9 Schematic depiction of main conclusions 468 841 836 PMC6986441__F1 Canonical pathway (Modified from IPA) for Opioid Signaling [−log(P-value) = 8.48; Z-score = 0.392] 5163 717 2932 572 673 1499 4609 2354 2353 4151 103 57468 PMC6986441__F2 Canonical pathway (Modified from IPA) for Corticotropin Releasing Hormone Signaling [−log(P-value) = 3.74; Z-score = 1.29] 6469 1392 7349 51083 116 133 9607 7054 51305 2002 1386 3725 3931 949 3848 4513 1394 4887 2834 5581 5443 PMC6988818__F2 The Renin-Angiotensin System and Vitamin D in Keloid Disorder—A Review 7421 4312 6402 PMC6989995__F1 Toll-like receptor 4 (TLR4)-KO aggravates dextran sulfate sodium (DSS)-induced intestinal damage by attenuating cell cycle and cytokine-cytokine receptor interaction 6502 5111 1017 23632 23595 7124 100187761 1896 7216 PMC6989995__F2 Toll-like receptor 4 (TLR4)-KO aggravates dextran sulfate sodium (DSS)-induced intestinal damage by attenuating TLR signaling pathways and enhancing the apoptosis pathway 7186 790 8772 27429 472 4199 7011 7975 23118 51135 920 PMC6990892__F12 Pathway signaling network generated from the top-ranking 1000 DM promoters 1438 3146 1441 4282 3576 170589 7010 374 9370 3914 1440 780 285 28514 2247 1513 551 2066 6608 7253 10683 182 2261 4067 3932 554 695 3861 27 5580 2779 6464 8717 859 815 1785 27071 26060 4853 5579 3269 6714 1017 3695 5045 983 5601 1018 55054 6195 613 64127 4851 2242 5292 1021 11040 7430 10392 6502 9055 1432 5566 83452 4217 8218 1111 54880 1613 208 9140 6197 8841 290 4155 814 3065 8536 127933 2932 10014 5587 604 8877 2274 831 6500 4137 1020 29904 3925 5608 7157 387 472 4831 367 2931 1499 115557 5879 4188 55657 8737 4222 3223 4654 5970 4617 5075 1999 10413 4656 5077 PMC6993271__F1 Actions of metformin in eukaryotic cells 6774 467 2475 PMC6994339__F1 Filtering through the role of NRF2 in kidney disease 9978 9817 8452 6420 2729 2730 1728 PMC6994496__F7 Proposed new pathway that operates upstream of the CRL2VHL complex and involves the UBXN7 cofactor protein and its regulation by mitochondrial MUL1 E3 ligase 79594 26043 6923 6921 8453 7428 9978 PMC6995557__F5 Schematic diagram of the proposed mechanisms by which betulinic acid ameliorates T-2-toxin-induced oxidative stress and diminishes T-2-toxin-induced apoptosis via the JAK2/STAT3 and BAX/BCL-2/caspase-3 pathways 3717 847 581 PMC6997470__F2 PAMPs exposure regulation in response to environmental signals 59272 64127 54106 6348 3553 PMC6999710__F1 Mitophagy and Innate Immunity in Infection 84749 57558 29110 9927 8887 139341 11331 7502 10133 4077 65018 664 PMC7001864__F1 Molecular Control of Canonical WNT Signaling 147111 4041 54894 22943 84133 83999 1855 8549 8312 324 847 1499 64840 PMC7001864__F3 Impact of WNT Signaling on Cancer Immunosurveillance 22943 3627 847 55509 50943 3620 PMC7004536__F3 Alterations in the oncogenic pathways in 88 NSCLC cell lines other than the CUL3‐KEAP1‐NRF2 system 1956 2064 238 5979 6098 5728 4893 3845 5266 5295 4763 6016 3265 207 6794 673 472 4193 7249 7248 7157 2475 8289 57492 1029 196528 6597 595 1019 898 5925 29072 7307 8241 PMC7007431__F1 Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma 55294 4522 29968 26227 5723 6470 4613 468 PMC7011106__F2 Gene-gene interaction among genes associated with atypical antipsychotic-induced lipid disturbances 4852 181 3952 3358 627 1813 4160 5443 1268 150 51141 PMC7012784__F2 Anti-tumourigenic JNK signalling 23513 5817 6092 PMC7012784__F5 Upstream regulation of JNK signalling 7124 9618 23118 4478 7189 5879 4312 474168 467 54704 PMC7013402__F2 Greatwall- Endosulphin Alpha (ENSA) pathway in the control of G1 and G0 27010 5464 27068 7465 253260 9 246184 PMC7014825__F6 JNK1-dependent IL-17 and TGFB signaling 84818 7046 7048 4087 4088 1386 4089 3569 2919 3589 2335 PMC7015662__F1 AIM2 inflammasome activation 10379 9447 115362 79792 80119 PMC7016007__F7 Crosstalk of metabolic pathways in AMD 57521 4140 4190 10038 23411 PMC7016888__F4 Cell signaling determination of artery, vein and lymph identity 2115 54345 2050 2296 5629 23493 23462 100188776 PMC7017417__F1 Scheme summarizing transient receptor potential canonical (TRPC) channel isoforms dysregulated under myocardial infarction (MI) and ischemia and reperfusion 7220 7223 7225 57113 7222 PMC7019526__F1 Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase receptor type B (BDNF/TrkB) signaling supports neuronal survival, plasticity, differentiation, and growth via activation of several functional downstream cascades 5335 207 2002 PMC7023272__F2 Resveratrol (RES) crosses the blood‒brain barrier via tight junctions 4255 6774 2475 PMC7024605__F2 Metabolic Immunomodulation of Macrophage Functional Plasticity in Non-Healing Wounds 10157 7099 3553 3603 PMC7027016__F4 Histone methylation plays a role in hypertension, aortic dissection, and pulmonary arterial hypertension 2146 9474 10533 PMC7027016__F7 Histone methyltransferases and demethylases are involved in tumor angiogenesis 3091 9112 84193 2305 7422 84444 2623 2146 4313 64754 PMC7029724__F4 Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies 1950 7124 1956 5728 324 572 54623 4193 637 5170 PMC7033713__F2 Summary of the effects of FGF19 signaling in specific cell types 181 4852 9965 PMC7037239__F1 IL-15 signaling pathways 3718 3716 6774 2885 9846 2475 PMC7037284__F1 Guanylyl cyclase-cGMP signaling pathway 594857 1267 5225 PMC7038066__F2 Proposed model of NO-dependent protein–protein interactions underlying GluA1 and GluA2 subunits’ trafficking 4905 1020 627 23237 PMC7038792__F1 NF2/merlin signaling and potential therapeutic targets in NF2 7852 1956 960 6714 7249 7248 1499 6009 3725 9113 26524 389421 4609 1969 PMC7039698__F1 Topical cholesterol/lovastatin for the treatment of porokeratosis: a pathogenesis-directed therapy 38 39 3157 3158 3156 4598 10654 4597 3422 91734 4553 2224 9453 PMC7042394__F1 Core components of the Hippo pathway in Drosophila and mammalian 4485 9113 81532 PMC7045041__F1 Possible central and peripheral effects of asprosin 181 2200 7099 6648 PMC7045519__F1 Known function of organelles in ferroptosis 8737 6774 25801 23657 468 2182 2879 375 79094 PMC7047626__F4 Mitophagy and DNA Damage Signaling in Human Aging 2922 472 142 7486 23411 7249 29110 115004 2475 65018 PMC7048131__F5 Advances of the STAT3 signaling pathways involving breast cancer chemoresistance 3976 3977 6774 1375 PMC7048211__F4 Proposed direct role of HTRA1 in bone formation 6955 650 3381 652 653 2475 4087 4090 4086 4089 PMC7048923__F6 PPI network of “drug-compound-target-pathway” of cinobufotalin injection for lung cancer 7124 2322 2272 2263 3791 2033 3815 3248 1991 2146 1806 4193 1909 4311 4313 4353 5241 11200 2475 768 5290 596 5468 558 5578 5743 6790 2185 5979 29072 847 367 836 7015 7276 6532 6714 208 1890 7298 7421 100 7428 PMC7049637__F3 Proposed mechanisms involved in the anti-fibrotic activity of rhein 1956 6774 6469 100653366 4312 2335 1000 PMC7052362__F2 Tumor-associated macrophages (TAMs) in promoting tumor progression and related mechanisms 9844 6774 961 100133941 140885 10859 89790 8205 348 PMC7053069__F7 Schematic of CPT’s anti-inflammatory mechanism in LPS-stimulated RAW264.7 cells 7099 4615 9817 PMC7054714__F5 Immune Responses to Viral Gene Therapy Vectors 718 727 3553 2475 115004 PMC7054754__F1 An overview of class IA PI3K signalling 5266 5163 7249 5728 47 84232 10628 3099 5208 468 11201 1977 29904 10797 790 4553 1938 3098 7405 9097 4609 4193 8408 7942 596 7157 595 PMC7054754__F2 Core signalling pathways maintaining human pluripotent stem cells (hPSCs) 2247 3630 4838 3480 4040 4041 4089 4087 1499 4609 4088 PMC7056731__F4 Crosstalk between Hippo-YAP pathway and NFKB signaling 7096 7097 7100 7099 51284 51311 54106 4615 51135 4485 3654 8717 7186 7188 7187 9113 26524 7189 84818 257397 23118 10454 3661 2920 2919 PMC7056731__F5 Interplays between Hippo signaling and ROS production 7096 7097 7099 4615 51135 3654 9817 4485 9113 26524 7186 PMC7057842__F2 Post-Translational Regulations of Transcriptional Activity of RUNX2 5300 860 2932 1019 PMC7059166__F2 Canonical Wnt/B‐catenin(WBC) signalling pathway 4041 4040 2932 847 324 51176 55366 8549 59352 PMC7059589__F2 Neuronal roles of atypical protein kinases (aPKCs).(a) aPKCs mediates nerve growth factor (NGF) response 4803 4040 4041 4905 3667 8660 51454 5163 2475 2932 6647 PMC7059628__F8 Comparison between wild‐type and gas7‐knockout neurons of mitofusin regulation by the PINK1 and parkin‐mediated mitophagy pathway 8522 65018 55669 9927 1020 PMC7060917__F4 Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang 613 958 324 4155 2056 PMC7060917__F5 Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang 2099 5468 3791 1956 5144 4048 PMC7069588__F4 Schematic diagram 999 1000 378938 PMC7069804__F2 Schematic of microRNA networks affected by HIV virus 920 23534 998 PMC7070543__F9 Schematic presentation of erinacine A prevention against MPP+-induced neurotoxicity via either induction of the p-PAK1/cdc42/PI3K/AKT/LIMK2 cell survival pathways or the reduction of the IRE1A/TRAF2/ASK1/GADD45/p21 cell death pathway 5058 3985 998 7186 PMC7071268__F3 Integrated overview of the metabolic changes induced by feeding the OBFR diet 2539 2645 5091 355 1431 2271 4967 587 PMC7071697__F3 Complex mechanisms and signaling pathways underlying VM formation 2932 4087 4088 9839 6935 1003 999 PMC7073516__F2 Fast and slow routes to break-induced telomere synthesis 5888 84057 5111 5985 5983 5981 5984 5982 10714 PMC7079523__F8 Pathway and temporal expressional patterns of oil accumulation 5091 5132 4018 PMC7079998__F3 STAT3 roles in viral infection: antiviral or proviral? 1956 9021 6774 6714 2475 406991 PMC7082279__F1 Resistant mechanisms of TKIs in target therapies of NSCLC 3084 2064 3484 3487 1956 6385 3480 972 238 27436 10342 3845 7462 PMC7082839__F4 AT1R signaling pathways activated by prolonged mechanical load or Ang II 1956 545 7222 7225 2475 PMC7084529__F11 Altered sphingolipid and gene transcript levels in ASAH1KD SH-SY5Y cells 81537 427 10715 56624 29956 340485 91012 2531 55331 64781 2629 6609 259230 6610 8560 PMC7085234__F1 RREB1-involved in MAPK signaling pathway 1956 2885 6239 PMC7085234__F2 RREB1 regulates different target genes in different cancers 6239 9181 367 27063 51129 PMC7086291__F2 Leukocyte extravasation signaling 3684 3683 83700 3689 3691 58494 3688 4318 3383 1003 PMC7094200__F3 Other signaling mechanisms regulated by RSV in a DCM heart 9817 2247 7099 7351 PMC7096478__F9 The possible mechanisms used by M 182 4851 861 PMC7096759__F1 Pathway map of pyrimidine metabolism depicting de novo, salvage, and catalytic pathways 2744 1373 790 129607 1723 5631 5634 7372 7084 340451 51727 377841 6470 1719 1854 351 1841 30833 978 1890 1635 1503 1806 1807 93034 51733 7378 1633 54963 PMC7097195__F2 Lysosomes as a therapeutic target 7942 107966124 28962 PMC7097628__F3 Rewiring cellular networks by members of the Flaviviridae family 6774 6772 6773 9140 55054 22926 83939 7494 468 3156 2194 1654 5297 5007 PMC7100557__F2 MERS-CoV inhibits innate antiviral signaling 23586 51311 51284 7098 57506 6773 3661 10379 PMC7113111__F1 Signaling pathways from three ER transmembrane stress sensors during unfolded protein response (UPR) in schizophrenia 22926 7186 83939 468 85451 PMC7113505__F2 microRNA (miRNA)–gene–pathway network based on miRTarBase and WikiPathways as described in the Methods section 4088 7048 1019 581 6774 4087 3643 57154 4092 4609 7248 6722 5728 2194 595 2549 596 3569 3791 3479 4089 896 3065 387 5747 7050 6688 6772 3091 637 9475 7040 4846 7422 2260 2308 51701 1499 7076 6935 51552 5594 207 PMC7117101__F2 Mechanisms by which SND1 promotes oncogenesis 27044 920 10253 5728 7048 595 1017 1869 1870 1878 8178 PMC7118069__F1 Major signaling pathways for protective mechanisms against ASD by SF 8452 9817 3297 7124 4513 PMC7120363__F2 Autophagy is involved in the regulation of the normal function of the intestinal mucosa and the pathogenesis of enteritis 9474 10533 7494 55054 345611 1081 PMC7125957__F1 B9 metabolism comprising the thymidylate cycle (red diagram), the methionine cycle (green diagram) and the purine biosynthesis pathway (blue diagram) 1719 5212 4524 4397 PMC7125957__F2 Vitamin B6 metabolism in humans 55163 4860 8566 PMC7131993__F1 Increased matrix stiffness can affect cells in different signaling pathways in colorectal cancer (CRC) 4040 4041 999 6714 6010 2932 324 1499 PMC7139330__F1 p38 MAPK activation 3932 7535 10454 PMC7139586__F5 The proposed role of nAChR signaling pathways in ISC function 7474 8549 154796 374 174 4092 4089 4086 3398 324 PMC7139634__F6 Most common target genes and mTOR pathway regulated by the differentially expressed exosomal miRNAs 2475 3643 5728 1978 3479 5170 5829 PMC7139637__F1 Hippo/yes-associated protein (YAP) signaling pathway in mammals 4771 60485 4485 9113 26524 332 PMC7139730__F1 Major cell death pathways: Apoptosis, autophagy, and necroptosis 7124 8717 8772 11035 197259 9140 317 PMC7139730__F3 The autophagy-induced anti-HCC polyphenols signaling pathways 2522 22863 9776 8408 100170220 PMC7140443__F1 Off state (left): In the absence of Sonic Hedgehog (SHH) ligand, Ptch inhibits signal transduction by SMO 6469 5727 6608 51684 2735 4609 6657 79923 PMC7140640__F4 Molecular pathways of the unfolded protein response (UPR 22926 83939 7494 468 PMC7140698__F9 Effects of Dot1L inhibition in influenza virus infected cells 84444 1283 7706 57506 29110 3661 PMC7141213__F2 Examples of mechanisms involved in the cellular response to low doses of phytochemicals–on the basis of findings presented in the current review 23411 2309 9817 PMC7141786__F1 Proposed model for the molecular events and mechanisms underlying the protection of autophagy against alcoholic liver disease 217 7942 65018 PMC7143281__F4 Tricarboxylic acid (TCA) cycle showing differences in gene expression and metabolite abundances in mouse liver 5163 5164 5160 5161 5165 5166 5162 1737 1738 8050 1431 50 4191 4190 3419 3420 3421 3418 6389 6390 4967 6391 6392 8801 8803 PMC7144542__F1 NFKB and MAPK signaling pathway in lumpfish 3553 4513 671 958 100187761 472 29760 10892 23586 929 100187907 695 1270 4803 1950 5970 6387 2669 627 4342 5155 7043 5478 780904 4149 4208 51701 PMC7144958__F1 XPF–ERCC1: Linchpin of DNA crosslink repair 22909 84464 2067 PMC7145850__F3 Quantitative results of sphingolipids and enzymes by LC-MRM-MS 56624 6609 8560 259230 64781 10715 2581 29956 7357 204219 125981 8877 130367 56848 PMC7147366__F3 Key metabolic pathways (glutathione metabolic pathway) involved in the interaction between GNPs and HDFs and the key metabolites involved 5184 51056 5182 PMC7149907__F5 Oncogenic seRNA participates in carcinogenic processes through activating various signal-pathway 100506119 2146 2932 920 4609 8626 6657 7157 1499 1956 387 961 1003 PMC7154970__F2 Regulatory roles of microRNAs in Tregs 4087 4088 6774 6772 3458 9612 10725 50943 PMC7156472__F6 Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer 6469 2735 5159 4597 PMC7157488__F1 Crosstalk between RNA metabolism and cellular stress responses during Zika virus replication 7097 7099 10333 3466 7098 29110 57506 6773 3661 57721 79068 54890 22926 83939 PMC7158223__F1 Post-transcriptional mechanisms influence proteome content 23367 2475 4553 PMC7158891__F3 An integrated overview of the immunosuppressive signaling pathways involved in the interaction between exosomal PD-L1 and T cells 940 969 941 7124 3002 3932 5493 8205 7535 PMC7160552__F2 Schematic diagram that introduces in detail the molecular mechanisms, clinical values and cell phenotypes affected by HOXA11-AS in different tumor types, including (A) NSCLC, (B) HCC, (C) glioma, (D) CC, and (E) BC 221883 5144 81704 6774 619501 3199 1019 1017 9113 1847 2146 999 11240 PMC7160552__F3 Recent advances in unraveling the molecular mechanisms and functions of HOXA11-AS in human cancers and other diseases 2638 221883 2146 1786 10365 5652 1499 100187761 4325 4838 3199 390 PMC7161485__F1 ADE and antibody mediated immunopathology. Left panel: For ADE, immune complex internalization is mediated by the engagement of activating Fc receptors on the cell surface 721 718 6772 PMC7162828__F1 Kynurenine pathway of tryptophan degradation 125061 8942 23475 PMC7167370__F8 Possible mechanism of miR-519d overexpression in HCC 581 10890 2475 9474 PMC7169063__F1 IFN production pathway and different ways that the virus disrupts this pathway 4615 51135 7189 3654 7187 29110 3661 3665 PMC7170819__F2 Angiogenic factors and receptors involved in GBM angiogenesis 1956 6774 2475 PMC7176583__F1 Gastric cancer: genome damaged by bugs 999 6714 1499 10392 6774 7189 324 2932 4513 1958 3553 54498 PMC7177258__F1 Regulatory system of the C-JUN N-terminal kinase (JNK) signaling cascade 1399 50488 2353 4087 4088 3727 1386 2002 PMC7177258__F3 JNK signaling in normal stem cells 4087 4088 79923 7018 8549 89780 8313 1386 PMC7177258__F5 JNK signaling in the stem cell niche 3146 6696 3371 PMC7178030__F1 Timeline of genes involved in gonadal development 56956 30812 6658 57647 50846 6736 6662 2626 7490 2018 23414 268 2254 2263 54361 5087 51176 7026 1499 84133 668 PMC7178193__F2 Adiponectin properties on healthy skeletal muscle 51094 26060 3667 5465 7018 PMC7179464__F1 Macrophage migration inhibitory factor (MIF) and cancer pathway 972 4282 3579 7852 960 572 581 PMC7179660__F8 Mechanism by which DDT inhibits oxidative stress and apoptosis in PC12 cells 1652 23411 581 PMC7182966__F3 Cancer hallmarks by the crosstalk between VEGF and Rho GTPase signaling pathways 51227 387 998 5879 6714 PMC7185127__F2 Regulatory mechanism of mitochondrial quality control 139341 4976 51024 56947 55669 PMC7186467__F1 Targeting mitochondria for the treatment of Parkinson’s disease (PD) 65018 6390 8165 PMC7187888__F6 Danqi Pill (DQP) targeted on HIF-1A/PGC-1A signaling pathway and finally elevated cardiac energy metabolism in the failing heart 7428 5465 6256 4899 7351 7019 5163 5166 PMC7188831__F3 Adaptors of Salmonella autophagy 29110 115992 10133 PMC7188969__F2 CD36 in Type 2 Diabetes Mellitus: Beta-Cell Dysfunction and Beyond 948 6714 114548 10628 PMC7189493__F7 Effect of X-rays on transcript expression of rat brain microvascular endothelial cells: role of calcium signaling in X-ray-induced endothelium damage 90550 5350 859 613 945 PMC7189798__F2 Death receptor and mitochondrial apoptosis signaling pathways and blocking TNFR1-mediated apoptosis by c-FLIP 8717 596 83737 8772 7186 PMC7190807__F9 Hypothesis diagram of the regulatory mechanism of Twist1, Tie1, Tie2, Angs, and Akt/Foxo1 in endothelial cells 7808 7291 7075 PMC7190872__F1 Toll-like receptor pathways 7096 10333 7100 7097 7099 114609 4615 7189 7098 54106 51311 51284 7187 3661 3665 PMC7190872__F2 Crosstalk between TLR4, NLRP3 inflammasome, and complement promotes neuroinflammation in Alzheimer's disease 114609 4615 7189 114548 3553 PMC7193283__F5 Mechanism of RES on improving NAFLD 4017 7099 6774 3603 948 5465 355 23411 22926 63924 5346 PMC7195796__F6 Effect of P17 reovirus on cancerous signaling pathway 983 1017 595 5728 1021 7175 PMC7195839__F4 Non-linear reverse-engineering method for inferring genetic regulatory networks 2672 2623 2113 4005 4851 8861 2624 861 6886 PMC7198709__F1 Biosynthetic pathways of NAD+ in mammalian cells includes de novo, Preiss–Handler, and salvage pathways, and the salvage pathway is the main source of NAD+ 952 10135 93100 203447 PMC7202399__F2 FOXO1 protein activation 2308 50507 2878 847 5734 PMC7202451__F5 Gene expression in the actin cytoskeleton signaling pathway for the hepatic transcriptome of S 3929 6714 2885 55970 89846 2245 1398 2316 5829 324 2934 PMC7203474__F3 Copper addiction of cancer cells could prevent the pro-inflammatory phenotype of macrophages 4015 595 8205 PMC7205831__F8 Systems pharmacology reveals the mechanism of activity of Physalis alkekengi L. var. franchetii against lipopolysaccharide‐induced acute lung injury 7099 847 3553 PMC7212757__F1 Role of Excitatory Cerebellar Nucleocortical Circuit in controlling associative motor learning 1431 7808 5091 1634 4827 PMC7216198__F8 Regulatory role of the IPs in immune surveillance in PB CD34+ Cells of PMF JAK2V617F mutated patients 3458 383 3105 6772 5720 5721 3659 6890 6891 567 947 PMC7217787__F1 Rapamycin use in COVID-19 59272 2475 960 7054 57506 914 100188864 341567 PMC7218056__F3 Hippo pathways in lymphocytes 4485 92597 55233 81704 5879 2308 2309 2152 387 9113 26524 79958 5872 2316 PMC7219112__F7 Gene-Concept network plot shows the linkages between differentially expressed genes for MAPK pathway-mutated (versus MAPK-WT) HNSCC tumors and GSEA enriched biological concepts 64083 9117 134266 55486 80145 64689 6142 55146 25873 6141 5701 6205 6203 131474 11070 55781 6209 6207 6161 6232 6228 9045 57449 6138 6231 26984 23647 101927423 6157 8405 3840 6187 92714 6502 51057 63891 6050 6181 3921 2696 6147 6159 6136 51808 55764 91147 6139 6158 51304 9197 57678 7318 6191 22916 51619 79072 57674 91942 6122 9958 114769 7110 25827 10605 26270 6229 6208 27258 10533 367 6194 581 2588 57060 3265 784 5721 84868 23521 3458 26253 115362 3717 90865 56253 3002 4168 51667 5699 3669 5720 2731 4615 1514 3001 2876 8320 9943 10093 1440 199 29909 10346 55845 5133 356 924 1154 3123 80380 51554 2921 8530 64343 1265 10870 2067 27166 4502 84174 8519 29110 10578 407035 7791 391 1938 3460 283463 6737 9976 25865 387 3824 3108 6846 713 327 55423 3811 55848 3805 932 60489 7941 225 57823 6398 10288 30817 2161 116071 5551 338339 3822 84630 9535 5265 164668 9473 400709 PMC7222183__F3 Charcot-Marie-Tooth disease (CMT) pathways related to oxidative stress 9927 54332 26353 PMC7225257__F1 Recent mechanisms of resistance identified in lung adenocarcinoma 10220 22983 472 675 672 7465 22974 545 142 10413 4087 PMC7226805__F1 Molecular mechanisms regulating autophagy 9776 60673 9140 8408 57617 22863 PMC7230071__F1 Key regulators of ferroptosis 8314 283871 9817 23657 6520 2879 2182 10162 4193 2643 PMC7232014__F1 Autophagy pathway overview, with childhood-onset neurodegenerative diseases affecting the pathway either directly or indirectly highlighted in red font 7249 6009 2475 22863 9776 60673 80208 11337 57231 PMC7232489__F2 Bifurcated pathway to synthesize hexanoic acid in M 3045 100187828 39 847 PMC7236196__F7 Combined proteomics and metabolomics pathway network map of significantly altered metabolites and proteins in ERG-positive prostate cancer compared to ERG-negative prostate cancer 353 2078 4922 1962 5091 2180 PMC7238364__F5 PPI network analysis of the overlapping DEGs 4792 5971 9099 5717 10283 5708 6649 203068 157695 254225 6730 4605 11143 6046 11275 4734 4651 23594 8660 10237 7804 8449 7277 PMC7240857__F1 Different expression of MAPK8 in breast cancer samples to normal samples 7039 5728 472 11200 1956 5447 3845 9429 2778 3077 2475 238 347 268 6790 4547 2033 2194 1017 53345 31 367 5465 6720 2875 1950 5241 4609 3630 3875 3265 26291 338 3952 9370 7422 7124 1571 5950 2064 56729 1401 PMC7240858__F1 Innate immune checkpoints influencing DC function in the TME 100133941 5627 4582 961 941 942 3146 10859 8205 140885 151888 PMC7242447__F3 Genetic variation and evolutionary history of a mycorrhizal fungus regulate the currency of exchange in symbiosis with the food security crop cassava 5810 5160 1738 1737 1431 2820 4018 5091 PMC7243250__F6 Signaling pathway of Bak’s neuroprotective effect against SAH injury which is suggested in the present study 10628 581 4318 PMC7246454__F1 DNA Damage Response and HIV-Associated Pulmonary Arterial Hypertension 11073 472 545 672 PMC7246472__F2 Activators and inhibitors of Wnt/Beta-catenin signaling pathway 6425 650 4488 1499 3146 5745 23411 860 PMC7246929__F1 Extrinsic apoptotic signaling pathway 7124 8772 8717 7186 PMC7247003__F2 Schematic presentation of key pathways activated in a colorectal cancer cell by three groups of cell membrane receptors 51083 2587 1956 1950 8811 627 2885 8772 PMC7247360__F1 Impact of Transcription Factor Prospero Homeobox 1 on the Regulation of Thyroid Cancer Malignancy 5979 5728 5290 7849 673 5266 PMC7255381__F4 Signaling of the VEGF Ligands, Receptors, and the Inhibitors of the VEGFA Pathway 7423 5281 7422 8829 8828 PMC7256023__F1 TGFBeta-induced epithelial-to-mesenchymal transition 64750 4092 4087 4088 6010 4089 9839 6935 7291 117581 6615 999 1000 7046 PMC7263617__F4 Expression of high mobility group B1 and toll-like receptor-nuclear factor KB signaling pathway in chronic subdural hematomas 3146 7099 4615 114609 51135 7189 3661 PMC7267062__F2 Death receptor apoptotic pathway in cancer induced by plant polysaccharides 355 8772 637 581 PMC7268735__F1 Illustration of CDC25C regulation (Green arrows indicate the enhancement effects and red indicator lines indicate the inhibitory effect) 983 8900 995 79866 5347 545 472 7465 5300 1019 PMC7272660__F5 Genes mapped to KEGG pathways by pathway analysis 4352 4351 2012 367 PMC7272661__F2 Graphic illustration of molecular autophagic pathway 8408 9776 60673 2475 22863 55626 7405 9140 9474 10533 83734 64422 79443 PMC7276297__F1 Biochemical pathway of steroidogenesis 1717 6770 1583 1586 1588 1589 1585 1584 PMC7278922__F2 Two distinct Fe/S cluster biosynthetic pathways exist in mitochondria (mitochondrial NFS pathway, left) and plastid (plastidial SUF pathway, right) in Arabidopsis 9054 200205 27247 150274 PMC7279300__F2 Signaling cascade of Dectin-1 6850 64170 10892 8915 5336 5971 114548 PMC7281073__F1 PI3K/AKT/mTOR pathway activation leads to cell growth, increased protein synthesis, inhibited apoptosis, cell cycle progression and proliferation 1956 5728 331 572 4193 595 2177 581 PMC7281113__F2 Main cellular processes inhibited or activated by the silencing of HOTAIR in BC cells 3236 26167 57575 595 2475 596 572 3856 2625 100124700 1462 5728 999 PMC7281325__F3 Multi-omic study identified up- and downregulated candidates in acquired trastuzumab-resistant BT-474.r2T cells compared to parental sensitive BT-474 cells 9217 4082 2017 2909 126353 10564 23584 5108 83548 28988 6247 1627 5829 79026 6711 4134 2316 4171 91754 5339 23524 9188 22806 1854 6920 8463 85456 6418 6599 4939 3627 3437 79156 6949 8479 3433 5469 80381 6373 9811 23493 445 282616 572 8495 8682 283463 92747 2331 3851 64073 2012 8000 57185 PMC7281370__F2 Carbon metabolism in Synechocystis PCC 6803 9896 1896 5183 6120 7086 PMC7281527__F1 Canonical microRNA (miRNA) biogenesis pathway 54487 29102 6770 PMC7284830__F1 Examined genetic variants involved in folate and vitamin D metabolic pathways 4522 5981 4524 4548 4552 7298 759 1719 PMC7286861__F6 The PGD2–GPR44 axis in human islets exposed to hyperglycaemia and proinflammatory cytokines 5163 2308 3651 389692 2932 PMC7286881__F4 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics 183 1636 2169 4023 5327 3827 5468 2335 4314 4318 5467 3991 4852 2155 3123 2244 2243 2247 3791 3156 26291 154 2147 4049 5360 462 6347 3953 7422 3458 2321 186 5743 7450 7057 59272 7018 3606 3091 3162 4878 4846 7124 847 6247 PMC7287178__F2 Proposed model of the cardiac sarcostat 1410 4077 9531 126393 26353 761 PMC7290354__F5 PI3K/Akt pathway can be activated in different ways, as for example by G-protein coupled receptors (GPCRs), integrin or cytokine receptors and it represents a mediator between ECM and fibroblasts’ cell cycle 5163 572 7249 7248 2475 PMC7290603__F3 Impact of tumor-derived EVs in Cancer Therapy Resistance 406991 331 2950 94241 406947 4292 1499 PMC7290664__F9 Extrinsic and intrinsic pathways of apoptosis 355 596 581 8717 8772 637 PMC7291112__F1 Roles of gga-miRNAs in host response to infectious bursal disease virus (IBDV) infection 9306 9021 10010 3660 PMC7295987__F4 Outline of the signaling pathways activated by CpG 930 5170 929 4067 54106 4615 51135 3654 PMC7299703__F8 Apoptotic signalling pathway 790 351 572 2191 PMC7300268__F4 YAP/TAZ regulation by lipid metabolism and YAP/TAZ-targets for Lipid metabolism 4018 1499 387 4485 355 3156 PMC7305134__F3 TIE-associated stem cell signaling pathways by ncRNAs 182 6608 5727 51684 100302142 2735 324 100124700 1499 6932 PMC7305134__F4 TIE and immune checkpoint molecules regulated by ncRNAs 407013 324 3717 406962 151888 407020 100616293 7535 2475 940 406998 407018 1975 5728 494332 100616241 84740 406948 100506237 103611090 104472715 PMC7306093__F2 Schematic representation of Trp metabolism and its influence on Tregs 3902 196 405 50943 PMC7306856__F1 Autophagy pathway 5538 2475 55014 29110 10533 64422 9474 8408 9140 60673 9776 55054 22863 26100 4077 PMC7307862__F2 Various classes of lncRNAs 100271873 6910 1482 57057 100126791 100124700 114004358 7808 8726 2146 400550 55384 50652 PMC7308426__F6 Pathway in cancer 5728 63923 5914 PMC7311976__F1 Wnt/Beta-catenin signaling pathway 4040 4041 1499 324 54894 84133 64840 7088 PMC7311976__F5 Deubiquitination in the Wnt signaling pathway 9098 4040 4041 7874 324 9736 7375 84101 9097 1540 8239 1499 55031 158880 29761 PMC7312468__F1 The MNK1/2-eIF4E axis 4893 4763 5728 673 2475 1977 PMC7312731__F1 Differential activation of downstream molecules of the insulin-like growth factor (IGF) signaling network 3479 3667 8660 5829 572 6774 2002 2353 2885 5163 6722 9021 PMC7312764__F6 Analysis of the major constituents in SHED-CM and the plausible mechanisms of SHED-CM-mediated neuroprotective effects 801 3489 7077 7040 3485 653 64221 64837 5728 4988 9456 5600 776 PMC7313057__F1 Bone metastatisation process 4015 655 1000 50964 PMC7313447__F7 Astragaloside IV attenuates high glucose-induced EMT by inhibiting the TGFB/Smad pathway in renal proximal tubular epithelial cells 4087 4088 1000 999 PMC7314312__F1 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism 5163 5728 7249 6009 468 4609 PMC7314312__F4 PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism 7086 468 790 10797 PMC7316088__F2 ATR/CHK1/WEE1 pathway compensates for the replicative stress induced by gemcitabine 11073 983 7465 545 84126 63967 494551 PMC7316088__F3 Hyperactivation of the ATR/CHK1/WEE1 pathway leads to acquired resistance to PARP inhibitors 983 7465 63967 545 84126 PMC7317091__F1 Summary of osteoclast differentiation induced by integration of CSF-1R, RANK, immunoreceptor-like and integrin receptor signaling 54209 1435 126014 1436 6850 2885 7189 5336 10451 4772 PMC7318814__F6 Summary of mechanisms of action underlying MEMP HT in BC cells 140805 2001 860 PMC7320752__F6 Protein interaction pathway analysis in metastasis 10000 54361 4176 23649 2260 6613 158 7481 28514 5358 4040 6612 56270 10055 7478 8074 84936 26508 2250 4172 3845 9965 11142 27006 3987 7341 5471 25996 51119 8648 51343 55388 3925 3725 2932 7320 6199 2252 7027 2253 7480 2100 673 1857 7483 9134 1855 6198 2475 26227 6932 80326 51176 5557 23594 7475 7476 26291 445328 581 4609 2246 2249 5291 4173 3265 578 85451 4851 7484 3480 5728 4041 254427 529 10016 7473 1635 89780 3815 6464 8600 282809 8324 25759 4855 26043 3476 23401 388585 2247 6252 23322 26019 1841 5241 8817 3093 84515 11211 23043 5604 1499 23595 10297 1956 2064 208 9406 5426 4853 8325 3280 53358 3641 4999 56893 528 5296 6654 10683 1026 2251 5295 23493 7474 672 54567 1633 81029 185 2255 8312 5223 7479 4854 1452 3676 3609 2885 10926 7471 182 2254 595 4175 4171 6934 7412 3714 10023 5686 10768 4174 4791 5000 1019 5001 7477 1950 8823 3479 8202 6667 5293 1017 2805 1856 5925 1643 1869 8844 5894 369 1870 1854 2324 84817 11065 26281 83439 8822 8317 5558 7157 207 2248 471 6655 9525 51506 2353 6456 7472 5427 79038 399694 1021 675 324 7855 134359 7319 2099 1984 51384 5290 1871 9040 9948 PMC7322557__F1 Molecular connections between components of circadian clocks and the immune system 729230 2146 6347 9575 406 6355 6279 6095 3603 4783 PMC7325873__F2 Graphical representation of DENV life cycle and subversion of the innate immune response: The virus enters the host cell through receptor mediated endocytosis or antibody dependent enhancement 3466 7099 6772 6773 5045 57506 7098 PMC7326080__F1 TNF induced canonical NFKB pathway 8717 7186 90268 23118 257397 81858 1540 5970 PMC7326080__F2 TNF induced cell death signaling 7124 8717 7186 8772 197259 3146 PMC7327075__F1 Interaction between ferroptosis and lipid metabolism in cancer 100 27165 4025 10162 2879 2638 2937 2182 6510 23657 6520 PMC7327349__F1 Graph of the IL-17 signaling pathway in KEGG database 4352 4351 8772 6955 8178 5340 3934 4318 4314 PMC7327477__F7 Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage 6135 6125 6502 PMC7335672__F9 miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells 100126333 4512 4049 6916 5740 5730 4048 4056 4050 5739 5729 56413 57105 PMC7338450__F4 GA12/13 signaling in metabolic diseases 9776 9140 22863 4851 3037 5212 PMC7339205__F7 PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/B‐catenin signalling pathway 5347 324 581 1499 PMC7340679__F1 Anticancer activity of mistletoe 637 596 4170 595 1019 1017 331 PMC7343132__F6 Comprehensive RNA-Seq profiling of the lung transcriptome of Bashbay sheep in response to experimental Mycoplasma ovipneumoniae infection 7097 10333 51311 4615 3654 51135 3553 PMC7343375__F2 Abbreviated diagrammatic representation of the PI3K, Akt, mTOR cell signaling pathway, and associated pathways, as a major regulator of cell function (see Laplante and Sabatini for a more extensive chart of mTOR-related cell signaling) 2887 5163 5728 7248 51256 6009 7942 64798 5225 9776 PMC7343851__F7 SSP regulation of PI3K/Akt signaling pathway 6009 253260 3796 8178 PMC7345337__F5 Gene–gene interaction network analysis 3643 4893 4342 7249 2887 3265 6446 7874 9462 1387 4193 9140 673 10318 8503 5601 8237 3479 2011 PMC7346062__F5 KEGG pathways related to resveratrol-targeted genes 207 208 10000 4193 8626 PMC7346753__F2 Multiple targets and multiple signal pathways of Huang Qin-Bai Shao (HQ-BS) herb pair against cancer 10499 8648 3356 3326 148 5294 147 367 1131 3569 153 5467 154 5733 1812 5743 5328 6256 5468 7157 3162 54583 3791 4312 5530 1017 3725 2100 596 4846 2932 2099 7422 1139 4843 126 1559 2946 7124 1576 6347 2944 6401 1432 10296 PMC7347488__F1 Renin angiotensin system enzymatic cascade depicting primary receptor systems, biological actions of Angiotensin 2 and Ang-(1–7) and balance between ACE and ACE2 59272 1636 367 PMC7352588__F1 Hedgehog signaling pathway 51684 6608 2735 2736 2737 PMC7352671__F2 Sorafenib resistance 619501 1956 1576 PMC7352710__F1 A-proliferation inducing ligand/B cell maturation antigen (APRIL/BCMA) pathway and its biological effect in the multiple myeloma bone marrow microenvironment 50943 595 330 4170 596 6348 3383 7038 PMC7353012__F3 Functions of UCA1, lincRNA-ROR, and lncRNA MIR2052HG in the tamoxifen resistance of breast cancer 652995 441355 2146 2475 1499 114783 2099 1849 6935 PMC7353012__F4 Functions of GAS5, DSCAM-AS1, and Eleanors in the tamoxifen resistance of breast cancer 60674 100506492 2099 5728 2059 PMC7356262__F7 Canonical pathway “NF-kB Signaling” for VA vs 1950 7039 4803 4049 958 114609 3932 4615 8717 8772 57162 7334 7335 5336 23118 257397 10454 5971 5966 5970 PMC7356262__F8 Canonical pathway “Osteoarthritis Signaling” for Epi C vs 4089 121340 1749 8841 6667 3516 3280 4520 3146 4035 7078 4319 4318 4322 10135 PMC7357716__F3 Metabolic Messengers: Adiponectin 1012 3643 4846 5594 5163 4513 759 23411 PMC7363449__F1 Acute Kidney Injury and Maladaptive Tubular Repair Leading to Renal Fibrosis 3925 4615 8737 545 PMC7367293__F4 Ingenuity pathway analysis (IPA) of actin cytoskeleton signaling in the Xenopus laevis whole brain after exposure to the predatory salamander larva, Hynobius lichenatus 1950 2335 6714 55970 28964 2316 1398 7204 5829 351 324 10458 10152 7414 2934 PMC7368075__F2 AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network 558 1956 7054 9404 6181 1809 9828 3297 56829 26037 9493 85440 5747 80315 84991 58506 10435 60312 54518 54961 2319 8874 57514 4628 5829 29890 9181 123169 5411 79834 9748 4739 1613 4691 54443 10890 23603 667 2037 7414 5093 1794 25 23332 8470 79026 23022 89 7791 5930 25802 55740 9590 9972 8994 103 116985 11273 6232 8562 171024 1398 7431 55323 10174 57091 5339 65979 6645 4026 6840 4082 55677 23049 6175 6386 3927 8976 4916 2909 4983 9749 122786 9322 5872 6525 2011 30846 6641 55667 90627 57551 23513 55103 4140 55701 2669 4649 23348 9414 8767 7249 9411 324 166929 10155 6793 3636 4659 4638 8502 8899 5786 10114 64062 5770 10006 9043 2885 58528 5784 203068 2932 7204 5286 4763 10188 8412 2260 5902 2050 1793 5290 4683 84932 PMC7373816__F1 Hippo-YAP signaling network 6714 9448 1022 51701 4485 9113 60485 154796 PMC7374916__F10 Schematic illustration of the proposed mechanism for H2R/H3R to alleviate microglia-induced neuroinflammation 7099 3553 2308 PMC7377904__F2 Activation of the Wnt canonical pathway induces Beta-catenin-regulated gene expression 2932 324 847 PMC7379086__F2 Regulatory Effects of O-GlcNAcylation in Vascular Smooth Muscle Cells on Diabetic Vasculopathy 8473 10724 860 PMC7379131__F3 Inflammatory Tumor Microenvironment of GBM and its Therapeutic Implications 6347 6387 6367 1950 50943 4282 PMC7379134__F8 Schematic diagram showing the crosstalk of the ASK1-JNK1/2 pathway and ER stress during DICD 7186 83939 7494 572 596 PMC7387650__F3 Regulation on the suppressive nature of MDSCs by subset composition and the tumor microenvironment 383 2475 11201 50943 PMC7388725__F2 Mitochondria and lysosomes in ferroptosis 27165 8031 2242 55240 2271 4118 6774 55847 2879 7417 PMC7392626__F2 cGAS-STING pathway in oncogenesis and cancer therapeutics 941 8480 942 115004 3661 3569 6373 PMC7394593__F1 The roles played by the TCA cycle and the Warburg effect in gastrointestinal cancers and normal tissues 4190 2271 1081 4967 5214 5210 79004 3148 3939 29117 PMC7398916__F5 BCR Signaling Pathway with FCRL genes 55364 79368 115352 83416 975 930 5777 4067 7409 3059 6452 5879 974 973 2534 867 6850 9846 640 1399 3932 6654 2885 5170 26469 3265 5295 7006 100124696 6464 2549 29760 7462 673 1398 27071 7410 695 5335 4690 25780 3551 23396 8394 5294 8517 2889 5336 4792 84433 4790 207 2308 1147 2931 2932 801 1871 5533 2113 8395 5970 5966 5530 5532 3608 5880 2002 4773 5894 4609 998 1385 604 3662 4208 6195 4149 4209 5599 3725 1386 5580 933 3635 PMC7399146__F3 Autophageal mechanism and stages 2475 8408 9140 9474 PMC7399975__F6 Tec kinase signaling and FAT10 pathway 7006 100124696 6850 8772 54331 6714 2309 695 PMC7401253__F5 Scheme highlighting the pathophysiology of neurodegenerative disorders and post-ischemic consequences along with indicating the underlying mechanism of neuroprotective action of algal compounds 43 348 627 PMC7401857__F10 Pro-inflammatory signaling molecules release upon HMGB1 stimulation and its receptor blocking 3146 7099 7097 4312 PMC7402325__F1 The canonical PI3K/AKT pathway with indication of key stimuli and central output functions 7039 5728 5163 1017 3099 5208 4193 6657 572 581 6194 PMC7402325__F2 PI3K/AKT pathway is a superordinate module of SOX2 and p53 expression control 6657 5728 5163 4193 581 79923 PMC7402325__F3 An ambivalence model of PI3K/AKT/SOX2 signaling and DNA damage control in various stem cell conditions 6657 100187761 5728 4193 79923 581 572 1017 PMC7403513__F11 The impact of CFTR dysfunction in HLMVEC on oxidative stress, inflammation and angiogenesis 1080 1956 6648 PMC7403652__F4 KEGG pathway with significantly enriched differentially expressed proteins 847 574 1636 4199 5241 572 4232 1017 472 355 619410 10572 64065 84883 5728 100187907 64326 PMC7403683__F1 Conditional reprogramming (CR) culture system and the potential molecular mechanisms of CR 1839 1499 6010 9846 5163 2475 960 4173 1612 PMC7403980__F7 Mechanistic scheme of anti-inflammatory signaling pathways of KMU-470 7099 3553 4615 114548 4513 PMC7404231__F2 Stress-response mechanisms 338386 59286 468 22926 83939 PMC7407108__F1 Hippo pathway 79633 122786 4771 154810 4485 60485 6010 9113 10494 9686 PMC7407194__F1 Autophagic Machinery 9474 9140 10533 55054 64422 8408 9776 60673 7405 55626 8678 PMC7407194__F2 DSB repair 472 2547 3014 5932 641 55183 675 5888 79840 PMC7407194__F3 Main pathways regulating the DDR-mediated autophagic response 142 472 26574 7157 5728 64798 7249 54541 7405 8408 9776 55626 8678 9821 60673 PMC7407487__F4 Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney 846 65266 1638 PMC7407977__F9 Molecular signal pathway of the proposed cell death crosstalk in B16 cells exposed to plasma induced-ROS 8772 10533 9474 581 PMC7408135__F2 Ether phospholipid synthesis pathway in peroxisomes 8443 3417 84188 55711 PMC7409063__F1 Extracellular vesicle (EV) biogenesis and signaling between neighboring cells 387 4827 11021 5873 PMC7410168__F5 Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control 3458 55601 3717 7297 115004 8651 11274 57506 3428 6773 29110 604 9636 3661 10379 4938 3441 1522 8519 151636 4599 10964 3434 5359 958 942 940 941 3566 29851 6774 6775 864 50615 643 PMC7411130__F3 Regulators of the complement pathway 717 718 1378 7448 966 730 729 721 PMC7411791__F1 Toll-like receptor (TLR) signaling in response to viral infection 7099 51135 7187 3654 7189 29110 8737 3665 3661 4615 PMC7412400__F7 Mechanistic map depicting the potential role of the HDAC1/LSD1/SESN2 pathway in VC in CRF 79885 2475 83667 PMC7412701__F6 Schematic diagram and potential mechanisms of sotrastaurin inhibition effect on osteoclast resorption 81501 54 1513 PMC7414235__F1 Gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19) 59272 1636 2475 6370 10803 PMC7415199__F2 Hypothetical diagram of the possible targets where melatonin may act against SARS-CoV-2 infection in the CNS 7097 3717 6774 114548 3553 7113 PMC7415260__F4 Signaling pathway visualization based on changed protein and transcript expression of SYN1, SYN2, SYN3, SNAP25, STX1A, RAB3A, and STMN1 in recurrent samples 6853 6854 8224 6616 100170220 6804 6844 11033 3925 PMC7416122__F2 Network of actual biochemical pathways constructed for S 84944 4118 8833 2023 11113 84706 4099 1040 2078 25913 PMC7418174__F1 Diagram showing mTORC1 and mTORC2 signaling pathways 3667 5163 64798 7249 7248 5337 6009 7942 8408 6194 PMC7423769__F4 Proposed network for BMP signaling in regulating energy metabolism via mTOR and HIF-1 9242 650 655 PMC7425302__F1 Cancer resistance to immunotherapy 941 324 3458 567 3459 3460 8205 PMC7426366__F1 Metabolism of sphingolipids 2531 6611 64781 PMC7426366__F3 Action of ceramide on insulin signaling and glucose metabolism in muscle cells 10715 26291 3667 PMC7429854__F8 Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy 1956 1839 3084 361 PMC7430912__F5 KEGG pathway analyses of DESR genes expressed across multiple time points implicated the Adipocytokine signaling pathway as playing a prominent role in successful CNS axon regeneration 2475 7186 9021 3952 3953 6774 181 4852 5465 PMC7432778__F6 IL-17A has two receptor complexes, IL-17RA/IL-17RC and IL-17RA/IL-17RD, in keratinocytes 7189 2312 3713 84818 PMC7432812__F2 Schema for the mechanisms for different types of cell deaths 834 79792 1687 355 8772 637 581 8739 90427 10162 572 2879 8717 7186 11035 197259 PMC7432832__F1 Aryl hydrocarbon receptor (AhR) pathway 196 57491 405 PMC7438559__F12 Working model of the experimental validation 3479 2475 581 9474 PMC7438937__F5 Pathway enrichments of SHGS 7884 4553 57819 25804 27258 51690 11157 27257 23658 29974 103 10642 54464 167227 PMC7441741__F3 Tumorigenic mechanism in somatotroph cells 83550 2691 2692 2696 9049 3313 PMC7446622__F4 Putative role of Gsk-3 in the SARS-CoV-2 replication and COVID-19 pathogenesis.Activated Gsk-3 phosphorylate the nucleocapsid protein of SARS-CoV-2 and support viral genome replication and transcription 114609 7189 9817 8452 1499 4615 PMC7448411__F1 Wnt/Beta-catenin signaling by miRNAs 6422 4040 4041 2932 324 10023 6774 100302142 9355 7534 4286 100126333 1000 6935 PMC7449758__F7 Proposed action model for the PI3K/AKT/FoxO3a pathway via ROS regulating DNA damage in the lung, liver, and kidney induced by Nano-TiO2 intratracheal administration 6098 7515 1647 PMC7450969__F4 Ribosomal/TRP53 pathway pattern mediated by Salmonella infection 207 6386 5728 2147 5663 25 943 6170 6133 355 5111 1019 5925 PMC7457135__F1 Protective and detrimental roles of mitochondrial reactive oxygen species (mtROS) during infection 7096 7097 7099 7189 2475 4485 51295 57506 25976 1329 9817 114548 11337 7124 23410 PMC7457231__F3 SMAD cooperation with different DNA binding partners 4838 4087 145258 83881 8928 51592 4088 4089 9113 26524 PMC7457231__F6 Cancer cells can traverse the tumor suppressive TGFB bottleneck by accumulating mutations (“X”) that disable the signal transduction pathway 3845 6935 51129 7852 PMC7458154__F2 Three Examples of Metabolic Transitions Influencing the Activation of Transcriptional Programs That Have an Instrumental Effect on Cell Fate Transitions 4092 4087 1499 PMC7459983__F3 Schematic description of genetic abnormalities (mutations or upregulation) associated with secondary off-target resistance to FLT3 inhibitors 2322 558 4893 3845 673 867 5781 5292 2475 171023 54790 1788 10735 3417 3418 PMC7461721__F5 Signaling Pathways Converge on Profilin 4088 387 6714 4087 4089 6093 3065 7428 7018 4318 4313 PMC7461813__F2 TM4SF1 promotes the development and migration of cancer cells 4071 780 3845 406989 1856 8745 6657 3717 6774 2475 5111 1000 7422 1499 581 PMC7463798__F3 Proposed signaling pathways affected by SphK inhibitors 56848 1674 2475 1499 PMC7463967__F4 Network of known interactions between RTKs and the Hippo pathway 1950 10461 5979 238 1956 6010 2048 83737 5163 3091 84962 9113 26524 2066 79923 8660 3667 6657 2744 6774 PMC7465316__F2 Functional proteins association networks identified by differential proteomic analysis and relative Venn diagrams 84823 7169 10726 7529 6181 10576 213 3921 5034 3326 7531 2923 60 PMC7465511__F2 MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment 7173 2057 4352 3717 3418 596 2475 3417 54790 3720 23476 10873 8233 6427 7307 8314 1788 6659 4211 6886 2623 861 PMC7465596__F1 Signaling and gene regulation of the canonical cell autonomous unfolded protein response (UPR) 22926 83939 468 7494 PMC7465660__F5 Relationship between EBV proteins, hTERT, and NOTCH signaling pathway and the modes of action of compounds with lytic induction potentials 9839 10538 2146 4436 PMC7466429__F2 Signaling pathways activated by catecholamines 3939 408 367 57646 4609 4193 6774 PMC7466429__F3 Stress hormones on the immune system 7124 4513 324 PMC7466743__F5 Targeting the CLL/MSC crosstalk using CXCR4/CXCL12 and BCR signaling inhibitors 9242 6387 613 7852 6850 4067 596 PMC7469280__F2 TRAF6 mediates signaling transduction pathway 4615 7189 51295 23118 10454 572 PMC7469991__F1 Common signaling pathway with miRNAs involved in the different malignant phenotypes of gastric cancer 648 407009 6774 4089 10413 10568 11228 7525 51684 4485 5728 5452 1499 6091 PMC7471609__F3 Metabolic map visualization for (A) redox and hydrogenases pathway, (B) pyruvate node that links glycolysis, incomplete Krebs cycle, anapleurotic pathway, and fermentative pathway, and (C) sulfur metabolism using the Escher tool 2232 828 10450 5091 4200 7851 5447 10465 PMC7473788__F3 The Hippo signaling pathway in mouse preimplantation embryos 154796 4771 9113 26524 10413 25937 7004 1045 PMC7474159__F9 New concept based on this study 5156 55107 847 PMC7477642__F2 Selected pathways relevant for plausible salvaging of residual ovarian function in primary ovarian insufficiency 3815 5728 2475 5888 268 PMC7479443__F1 De novo purine synthesis pathway 353 2618 158 10606 7808 8833 PMC7481416__F3 Different pathways in cancer targeted by p-PROTAC 324 999 1499 6925 PMC7482583__F1 LRRK2’s potential involvement in pre- and post-synaptic pathways 120892 4905 23557 100170220 55737 PMC7483747__F3 IPA TGFB signaling canonical pathway analysis overlaying the WT specific gene list: genes significantly differentially expressed (adjusted p < 0.05) with a |FC|> 2.0 uniquely in WT, E16.5 versus E14.5 5053 1356 2885 6955 4838 5979 673 145258 3196 PMC7483800__F1 SARM1 Axon Degeneration Pathway: Control of the NAD+ Metabolome Regulates Axon Survival in Health and Disease 11075 23057 23098 6500 PMC7484401__F4 ANM analysis on long-term PIMi treated cells finds changes in protein complex enriched for signaling and growth pathways 5971 2252 54541 6778 3560 3479 8743 330 5106 7185 3454 958 4846 10018 3326 7422 3383 7412 3672 2475 55367 1026 3725 5328 3451 4790 54205 2322 7057 3480 3459 207 4616 836 894 6655 1978 5777 472 10971 1021 8797 4609 10401 5579 5293 6775 4067 4602 1512 2149 581 71 7128 58528 2932 7184 PMC7484613__F1 Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6 54790 3569 3553 PMC7487050__F1 Brief summary of miRNA biogenesis and aspects of regulation in breast cancer and metastasis 54487 29102 56339 23405 27161 1956 999 10253 PMC7487050__F2 Metastatic process in breast cancer 100126306 693122 57167 999 100506658 1000 7291 9839 6935 2335 8061 3199 5054 3569 7422 6387 55662 100653365 PMC7487050__F3 TGFB stimulation of EMT, angiogenesis, and stemness in breast cancer progression toward metastasis 387 5728 79923 57167 7046 7291 7422 3236 389 4087 4088 9839 6935 4089 999 442917 574476 8091 182 3714 28514 10683 54567 407054 7054 4855 4851 4854 4853 574511 693122 664613 102 6868 PMC7490109__F1 Possible mechanism of SARS-CoV-2 mediated innate immune response at the lung alveolar cell 59272 51311 51284 7189 6347 6355 3553 PMC7491318__F11 Protein interaction network for 105 DAPs listed in 991 147841 79770 1164 123 84271 9823 51203 135228 8721 5352 9168 1062 2632 5351 26355 11130 10404 3337 63922 8974 7371 2619 5118 152007 51070 10397 5163 93621 4921 25994 3995 116461 57333 4323 5436 5438 5430 30008 51150 2887 55089 2997 5743 5431 23387 5176 3162 1277 10169 2790 25879 2019 558 721 3716 4718 4697 29889 1514 6880 10412 9933 9682 6678 1153 51255 11186 10209 6386 23612 56902 54407 10289 55324 115817 56941 PMC7491975__F2 Different regulation of angiogenesis and vessel stability between VEGF and angiopoietin signaling, relating to regorafenib action 1003 7075 6714 387 PMC7495669__F5 Gene-vocalization links 51729 121278 79625 55110 10371 2937 53938 4922 6492 55033 7849 29098 1644 PMC7497849__F3 CCL5-VEGF-A signaling pathway in BEV treatment 51621 6348 1234 7422 PMC7500051__F5 Opposite immune effects of M1-like and M2-like TAMs in the tumor microenvironment 920 383 1051 8205 3586 6367 6364 6352 7054 50943 3458 PMC7501977__F1 Underlying mechanism of mitophagy in influencing COPD with different phenotypes 114548 8139 10133 4280 65018 79442 57506 197259 PMC7503488__F1 Actions of metformin on immune cells, blood platelets and endothelium during the development of neurodegeneration disease: Metformin has multiple properties such as anti-inflammatory, antioxidant and antithrombotic properties 7450 5196 920 PMC7504460__F2 Insulin-PI3K signaling facilitates cell proliferation and glucose metabolism via serine/threonine protein kinase B (AKT)-dependent and -independent mechanisms 10628 2475 226 6194 PMC7504854__F3 Mechanism by which A20 regulates arthritis 3553 7124 8772 8717 4615 7186 7188 7189 8737 23118 257397 11035 197259 79792 114548 PMC7506548__F2 Non-canonical NFKB pathway 7124 7186 7187 91662 56957 29110 57162 5971 55611 PMC7510089__F4 Key gene analysis in the OS 2305 1050 960 2247 5430 5468 1958 388 5880 3725 847 627 3320 338 4313 6774 5295 249 3569 6387 6790 7298 7424 59 1956 23710 3667 1647 891 8660 9133 4616 6446 10733 604 PMC7510089__F5 Key genes analysis in the AD 847 3725 960 5468 3576 5880 3569 595 983 2247 4609 7422 8505 5728 6387 6774 113 4254 285 3815 4803 284 5578 7424 2252 5295 2889 7010 56034 1969 2250 80310 109 PMC7513299__F1 Adipocytes in EOC metastasis 3479 3082 960 999 PMC7515865__F3 PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers 2475 331 1977 637 572 PMC7520847__F2 Wnt signaling pathway 4041 4040 847 324 8312 PMC7520849__F1 RAD51 function during HR and replication fork reversal and protection 672 1763 9156 5888 675 79728 1045 348654 84464 PMC7523021__F2 Integration of networks of SFH targets 1128 1131 5350 154 487 1139 5530 1129 4842 4843 147 3356 4846 8877 1950 1956 2885 7157 3725 7124 7186 3315 7535 27040 29851 2932 940 2149 3791 3667 572 596 4193 PMC7523401__F7 Distribution of partial targets of HQ-BS on the IBD pathway 3558 59067 324 149233 3586 PMC7525950__F2 PI3K-mTOR autophagy pathway utilizes PIP3 lipid signaling 5163 5728 8408 7248 7249 6009 PMC7526978__F2 Z-nucleic acid-dependent inflammatory signaling pathway 197259 11035 8737 81030 PMC7527139__F1 Summary of metabolic networks in iFermCell215 1636 100379198 4163 11113 4118 PMC7527241__F7 Serum discrimination and phenotype assessment of coronary artery disease patents with and without type 2 diabetes prior to coronary artery bypass graft surgery 9972 5649 80331 80274 3908 94025 1806 8924 84726 140453 727897 50802 3535 23303 3494 4583 3625 80208 80731 7455 340895 84467 7148 3339 6955 9254 4853 8029 114784 4035 7450 6957 55172 26057 2201 23345 7273 10699 PMC7530063__F8 Vitamin C regulates Schwann cell myelination by promoting DNA demethylation of pro-myelinating genes 57716 4155 7368 PMC7532113__F1 ERBB family comprises four receptor tyrosine kinases including the epidermal growth factor receptor (EGFR) 3480 3084 2885 2475 PMC7534062__F8 Schematic diagram depicting the effects and mechanisms of TPH-1 against renal fibrosis and the regulation of PAA on TPH-1 expression 1499 324 8312 7166 PMC7535936__F5 Schematic outline of the Nodal signaling pathway in vertebrates 4838 2657 9573 4087 4089 8928 PMC7537965__F1 Workflow for drug and vaccine repurposing 4312 3569 6349 100188776 4092 6909 1978 24148 441869 7536 329 5763 83933 51230 3552 6364 2745 1437 3458 6348 11009 55170 7124 2152 2359 2219 7045 199 11031 183 283455 6472 4067 154 7077 6039 27239 284013 4069 6369 920 3565 PMC7539288__F1 NAD+ metabolism and its physiological function 130013 23475 23530 93100 10135 952 4837 23098 PMC7539839__F1 Mitochondrial roles in health and disease 55669 9927 4976 2242 65018 PMC7542117__F5 Core HIF-1 signaling pathway in THSWD against DR 7099 7428 8453 2056 7018 7037 7084 3939 3792 5054 4843 7422 2321 3630 2597 3480 3479 PMC7547805__F2 Regulatory mechanisms of TEAD in cancer biology 4485 9113 26524 4318 3488 558 7004 6657 4609 6925 3661 PMC7549162__F6 Comprehensive network construction of crucial signaling pathways and DEGs associated with HBV-ALF 6654 51744 3122 10870 5880 3133 3113 3123 7305 5551 1520 6850 3115 3109 3002 3108 3932 3117 3384 3106 2207 6890 3111 3105 PMC7549391__F2 Metabolic Messengers: ceramides 948 2531 253782 29956 204219 10715 79603 91012 56947 427 6720 51094 79602 PMC7550695__F1 Molecular players involved in the NRF1 pathway 55768 4899 8473 9958 PMC7550743__F3 Amino acid metabolism regulates PDAC progression 999 23657 2932 2309 387 4312 3845 4199 3297 2806 2568 6374 3783 440 2475 PMC7553077__F2 Recent advances in engineering different immune cell types for immunotherapy applications 1234 60468 3662 567 5079 1020 3902 639 6868 1043 135 924 958 5728 9423 945 PMC7554194__F2 Other signals that regulate Schwann cell development 999 4099 5028 53616 324 1000 55366 8549 59352 5029 387 4018 5027 PMC7555132__F3 Cdc48-dependent MAD and mitochondrial quality control mechanisms 197131 54820 10075 65018 9927 PMC7555565__F3 Mechanistic network showing the highest score for a set of significantly differentially expressed genes in MG (methylglyoxal)-treated rats 11016 1386 2549 11221 8412 3667 6871 1616 7514 4710 5151 9572 3043 5997 9882 5166 9839 1154 94241 PMC7555565__F5 Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model 1616 2885 2549 1850 3667 1386 2002 PMC7557985__F1 Involvement of p38 MAPK, ERK MAPK, and NFKB signaling pathways in osteoclast differentiation mediated by RANKL and BMP2 650 100187907 81501 PMC7560924__F5 Resistance and response to insulin by mTORC1 2885 7249 7248 6009 PMC7563273__F1 The activation and regulation of the PI3K/Akt/mTOR signaling pathway 3667 5728 5163 64798 7248 6009 1977 6194 PMC7563273__F3 Targeting the PI3K/Akt/mTOR pathway in AML 5728 3667 5163 7249 7248 6009 1977 6194 PMC7563540__F2 Exosome biogenesis and release 960 928 967 3732 7251 PMC7563728__F1 Metabolic pathways and Snail target enzymes of catabolic metabolism 57103 8789 2147 7086 2203 6888 PMC7564075__F4 Signaling mechanisms of CD271 6272 65078 4909 4908 4922 4803 627 7189 2885 4893 387 3725 673 6093 9475 3984 7430 5962 4478 PMC7564842__F1 Receptors and signaling pathways that activate the NFKB cascade 7186 4615 51135 7189 PMC7564852__F1 Wnt canonical (Beta-catenin-dependent) pathway 4040 4041 324 1499 84133 54894 8549 7018 PMC7564852__F5 Chromatin modifiers involved in Beta-catenin-dependent transcriptional regulation and their roles in the Wnt pathway 8289 57492 2146 9869 84444 10419 8295 1499 3065 3066 23411 55693 23028 PMC7564905__F1 Signaling mechanisms mediating the actions of neurotrophins 2885 2549 581 2475 4193 572 2932 2308 6772 6774 4609 PMC7564998__F1 Oxidative stress, mitochondrial dysfunction, axonal transport, and glutamate excitotoxicity in amyotrophic lateral sclerosis (ALS) 4744 57679 9217 2521 7415 23064 10133 6311 PMC7565022__F1 Hedgehog (HH) signaling pathway 6608 51684 2736 2737 2619 PMC7565022__F4 Protein arginine methyl transferase (PRMT)-mediated modulation of glioma-associated oncogene (GLI) 1 or GLI2 activity 10419 54496 83737 2735 2736 51684 8650 2619 3276 PMC7565591__F3 Coupling of signal transduction and (default) pathways affecting mRNP formation and mRNA fate 7189 167227 55802 23644 54464 PMC7566085__F4 Identifying Drug Sensitivity Subnetworks with NETPHIX 2064 1956 613 695 4194 472 4609 5925 4193 50853 7150 PMC7567008__F1 Tumor-cell-intrinsic roles of Yap/Taz in regulating tumor immunity 8205 4485 9113 26524 PMC7567935__F15 Pre-treatment of rats with melatonin (10 mg/kg bw) prior to ISO treatment (25 mg/kg bw) prevented occurrence of myocardial infarction and averted mitochondrial dysfunction caused by ISO mediated oxidative stress 4025 23411 5225 23410 PMC7567953__F1 Sphingosine-1-phosphate (S1P) production and S1P/S1PR signaling pathways 124976 1901 9294 1903 8698 53637 56848 8877 6010 PMC7568023__F2 Engineered nanomaterials as fighters against SARS-CoV-2: The way to control and treat pandemics 594857 59272 721 PMC7573281__F4 Signaling pathways over-represented by genetic variants and differentially expressed genes Over-represented pathways and related genes are plotted 51206 1292 1294 1299 4968 5336 328 391 6616 6854 5428 5423 5426 7057 23705 2237 5111 3978 8997 50618 10160 5879 PMC7573576__F4 Synthetic lethal pathway: multiple pathways 2624 4899 7189 6010 2670 PMC7576257__F1 TRAIL signalling pathway 637 8772 8717 7186 581 331 PMC7578249__F4 Impaired monocytes function in ACLF 10461 90865 3556 6761 729230 941 7099 920 PMC7578260__F2 TRIM-mediated regulation of the TLR signaling pathway 55223 4615 4118 7098 7099 10475 81844 51135 3654 3656 7189 7187 373 257397 10346 6737 81603 135644 10206 23650 5987 117854 114088 3661 3665 5300 10155 PMC7580254__F9 Schematic diagram representing the role of Bruton's tyrosine kinase (BTK) in the pathophysiology of sepsis 7097 695 3553 2919 PMC7582682__F1 On the hematopoietic cell surface, transient receptor potential cation channel subfamily M member 7 (TRPM7) and magnesium transporter 1(MagT1) facilitate magnesium influx into the cell 84061 54822 2475 595 5111 860 3553 PMC7583940__F1 Canonical pathway of microRNA (miRNA) biogenesis 29102 54487 26523 192670 27161 192669 PMC7583994__F1 Rearranged in transfection (RET) receptor structure and its intracellular signaling pathway 9518 389400 2886 2887 6774 6714 1796 5266 3667 8660 10818 PMC7584116__F1 Ca2+ regulates metabolic pathways at different stages of the T cell life cycle 324 942 941 10645 24145 PMC7585830__F5 Summary for Inhibitors of the upstream hepcidin signaling: IL-6/IL6R/JAK/STAT3 and BMP/SMAD pathway 654 406906 148738 3717 6774 4089 57817 PMC7586431__F3 Statin therapy for coronary heart disease 4175 4176 5879 1017 387 PMC7588666__F1 Base excision repair and its implications to cancer therapy 7374 4968 79661 11284 8505 7515 2237 5111 3978 PMC7588667__F4 DNA damage response in amyotrophic lateral sclerosis 8878 9025 472 165918 6311 7415 3065 2521 129831 142 PMC7588841__F2 Cancer Stem Cell Niche 1950 3976 3977 2885 6714 1398 2549 6010 4090 4086 324 2932 2475 6774 57167 9314 79923 27022 6929 6657 1378 1380 2626 2627 132625 55183 1045 6926 PMC7590211__F4 TRIMs on proinflammatory STAT3 (A) and NFKB (B) signaling cascades in CRC 55737 3717 5987 3716 6774 8877 9830 23650 135644 5966 11074 9097 5971 10563 6363 6366 PMC7593515__F2 YAP/TAZ by core components of Hippo signaling pathway 4771 4485 60485 9113 26524 558 PMC7593515__F3 Hippo signaling pathway and potential inhibitors of YAP/TEAD 6010 9113 26524 718 3667 8660 154796 2885 23476 PMC7593815__F2 Illustration of the cellular context and key processes in which MPEG1 is implicated 3458 4615 7124 1957 PMC7596324__F1 Mitochondria-targeted Therapies 1493 2475 940 3558 PMC7596389__F10 Probable protective mechanism of UDCA against As(III)-mediated cytotoxicity in vivo and vitro 847 1728 581 PMC7599155__F2 Dna2 is an essential gatekeeper to HR-dependent restart of stalled replication forks 1763 5888 80119 PMC7599585__F3 Distinct mechanisms leading to Nrf2 activation in cancer cells 9817 8452 7706 64122 PMC7600158__F1 MicroRNA (miRNA)-mediated modulating response to gemcitabine 100302149 2932 324 5728 6714 3976 1499 5163 57447 4771 6774 9575 PMC7600388__F1 Summary of hepatic lipid metabolism pathways altered in NAFLD and driving dyslipidemia 5465 26291 255738 2194 3949 80339 7038 55908 27329 PMC7600400__F2 Reactive oxygen species (ROS) removal and effects 23530 57716 6647 6648 PMC7600741__F3 Ca2+-signaling pathways and HCC cell apoptosis 6786 84876 90550 PMC7603631__F6 Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1A Signaling Pathways Mediated by the NAMPT-NAD Pathway 10135 22933 23411 23410 847 PMC7606465__F7 Next-generation sequencing analysis of circulating micro-RNA expression in response to parabolic flight as a spaceflight analogue 1017 7157 4193 1869 472 1019 PMC7611899__F1 Fibrosis development and signaling pathways 4092 4087 4088 4089 1499 102 5966 7099 2475 PMC7612338__F1 ISR signaling pathway 1998 9812 115209 55364 83939 468 PMC7641864__F7 Metabolomics analysis of the mechanisms of hUCMSC treatment for POI 336 4975 326 PMC7643360__F5 Summarized diagram proposing that IGFBPs secreting PD-MSCsPRL-1 are the key antiadipogenic factors inhibiting adipogenesis in OFs from GO patients through upregulation of FAK and downregulation of the PI3K/AKT/mTOR signaling pathway 3667 5163 5728 64798 PMC7646179__F1 FGF/FGFR signaling pathway 1356 10818 1398 2885 1793 2549 2475 351 PMC7650612__F2 Influence diagram of the molecular interactions implemented in the model 1950 3273 2064 2065 2066 2549 2885 2002 PMC7653026__F3 NFKB inflammation signaling pathway diagram 7096 7100 10333 7099 4615 7189 PMC7653700__F3 T cell senescence-related signaling pathways 3932 2626 472 7535 115004 10454 7015 2475 6774 6772 PMC7654518__F3 Molecular mechanisms of SGLT2 inhibitors on iron homeostasis, mitochondrial function, and cardiac microvasculature in diabetic cardiomyopathy 55669 9927 7019 51024 PMC7657020__F3 Predicted interaction map of SARS-CoV-2 proteins and top 20 host proteins associated with cytokine signaling pathway and Neutrophils degranulation 595 7316 5970 1956 7311 7314 3265 4790 6714 6774 5599 207 4893 1950 7124 102 2040 1535 23352 2548 54918 8673 966 55754 10043 8773 1536 3684 3689 5337 719 527 PMC7660609__F2 Role of HO-1 in I/R injury and cardioprotection 442904 718 50975 PMC7663205__F2 Role of PITPNM3 in cancer cell migration 8205 83394 6362 2932 2475 7412 PMC7664917__F2 Signaling pathways in ferroptosis 23657 6520 2182 2744 7296 2879 8031 PMC7665057__F6 Predicted pathway and network of all the 11 miRNAs 7068 8773 7067 2280 51274 3576 7422 116150 26281 5295 3572 8863 8864 3091 51454 79581 3586 788 604 PMC7667664__F1 Efferocytosis in health and disease 2621 4035 10461 575 9844 5879 19 6446 5087 PMC7667664__F2 Efferocytosis in health and disease 7124 961 10461 2621 4035 6868 387 2056 8754 5468 948 PMC7672255__F2 CYP1B1 as a therapeutic target in cardio-oncology 1545 196 405 PMC7672660__F5 Lipid mass spectrometry imaging and proteomic analysis of severe aortic stenosis 197 3273 3507 821 3075 5005 6906 336 335 3043 714 2209 3232 7018 1634 3458 3858 710 51056 7057 713 165 183 4969 3697 5806 596 11033 81494 2192 5478 731 344901 2878 3500 6597 PMC7672768__F2 Protein-protein interaction (PPI) network constructed using the STRING online database and Cytoscape software 3851 8434 7373 3918 4629 22974 10468 5329 5744 5621 4351 5328 351 6387 1191 1805 5550 1675 5764 2520 9435 7037 8404 224 3371 316 125 PMC7673349__F2 Hypoxia regulates CSCs with HIF-1 as the core 6469 216 960 6657 961 79923 PMC7674854__F1 Schematic overview of insulin signaling and glucose utilization pathways in the brain 3667 2475 2539 2821 PMC7677305__F4 Activation of the cGAS-cGAMP-STING pathway mediates obesity-induced inflammation and metabolic disorders 3661 115004 29110 PMC7677787__F2 Lysosomes function as an intracellular signal transduction platform 2885 867 7249 7248 6009 PMC7680337__F3 Signaling networks involved in Ras-driven oncogenesis 7074 5900 11186 PMC7680400__F4 Synaptic microRNAs in Alzheimer’s disease 574436 9900 6844 6616 6804 6857 5770 23411 2048 8828 51299 PMC7681076__F4 Proteaphagy: selective autophagy of inactive proteasomes 1356 6184 8723 PMC7683115__F7 lncRNA-miRNA regulation mechanism diagram based on the AGE-RACE signaling pathway 55384 440823 7045 183 6774 5292 3717 60674 105369900 PMC7686960__F6 Proposed model showing the suppressive mechanisms of Maackiain in RANKL‐activated NF‐KB and NFATc1 signalling pathways 4772 1513 54 4318 PMC7689098__F1 KLF9 regulates cAMP signaling pathway genes in HT22 cells 7074 7410 64411 387 5906 5894 268 808 2353 3725 6010 627 PMC7689098__F9 Proposed model for the repressive actions of KLF9 and KLF13 on cAMP-dependent neurite-outgrowth 5906 5894 687 51621 808 PMC7689184__F16 TNFSF15 regulation of antimicrobial pathways 9966 8717 8772 64127 7186 10892 3603 5163 9474 4843 55054 PMC7690450__F2 Curcumin, as a multitarget compound, induces apoptosis and cell cycle arrest in neuroblastoma (NB) cells through the modulation of PTEN–Akt, NFKB, and p53 signaling; mitochondrial dysfunction; and caspase activation 5728 355 2309 637 572 PMC7690808__F1 Transforming growth factorB (TGFB) signalling pathways in tumorigenesis 7046 7048 4092 387 4087 4088 4089 8195 2475 999 7431 PMC7691485__F3 Basic components and rough characteristics of each indicated signaling pathway in relation to primary cilia 7048 4089 4087 4088 51684 156 6608 2717 1956 5156 PMC7692672__F1 Synthesis and metabolism of sphingolipids (SLs) 2744 5091 1674 PMC7693470__F1 Schematic simplified representation of thyroid hormone synthesis 7038 2877 7296 PMC7695367__F7 The proposed mechanism of radiation-induced tumor repopulation in NSCLC 836 3014 472 2021 PMC7696687__F1 Three-mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis pathways 952 64802 349565 23057 PMC7696687__F3 Various physiological roles of intracellular visfatin (iNAMPT) 203447 65220 952 51547 23411 51548 23410 22933 23057 349565 64802 PMC7697663__F1 c-Jun/activator protein-1 (AP-1) regulation and biological activity 940 1386 3662 10538 PMC7697962__F2 Top two networks constructed by ingenuity pathway analysis (IPA) showing interactions between the top 100 differentially expressed genes (DEGs) in the dendritic cells (DCs) from patients with allergies 2922 5054 1390 5624 4323 920 7733 10938 208 5603 2078 PMC7699465__F1 Nelfinavir inhibits the Nrf1-dependent synthesis of proteasome subunits and inhibits the proteasome, leading to accumulation of misfolded proteins that activate IRE1A and PERK arms of the UPR 4899 3091 4193 5979 4087 22926 6774 4286 83939 468 83667 57761 2475 1017 993 5111 PMC7699570__F2 Signaling targets of CO 114548 1958 3146 PMC7705238__F1 IL-23/IL-17 signaling transduction 149233 84818 3717 7084 6774 7186 7187 9618 PMC7709568__F5 Pathway enrichment analysis of (A) significantly higher expressed genes and (B) significantly lower expressed genes in T47D cells after glucose deprivation 4094 81631 6520 467 7184 1649 7453 2081 10130 2730 3162 23657 2512 4189 2495 811 57761 5611 2949 3309 8878 2258 7296 2877 2936 6526 3303 5932 2177 63967 2237 83990 2305 3014 675 80010 55215 5888 2175 545 11200 4171 5347 990 55388 9700 5558 10926 5933 9232 9088 5424 580 5111 1111 1031 23649 4174 1017 8318 51053 5982 699 4175 4172 4173 595 5426 5985 993 9134 890 7272 8317 898 5427 5422 6119 891 6502 5984 5983 9133 10714 6240 54443 1719 7298 7153 10592 6241 24137 2956 3146 2189 PMC7710136__F9 Cross-talk between metabolic, inflammatory and muscle growth pathways in dystrophic muscle 3458 7124 9759 3611 4208 23411 253260 5465 998 7019 2101 54205 PMC7711540__F5 Validation and pathway analysis of elevated S100A8 protein in FSHD 6279 6280 3868 7114 9168 3725 3479 7099 2353 5216 5624 1072 7171 23731 79646 286410 106614088 10075 10427 399959 348235 PMC7714932__F2 Ischemic heart disease: the roles of miR-21 in CMs and CFs.Reported major signals in CMs 27250 5728 4092 4087 4088 355 4313 PMC7714932__F3 Cardiac hypertrophy and HF: the roles of miR-21/miR-21-3p in CMs, CFs, and ECs 5728 10252 4092 55869 2932 PMC7720107__F5 TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation 4615 2932 383 PMC7720404__F1 TF-miRNA-gene network 5330 8503 5880 5900 9475 861 801 2885 10000 5934 816 10298 6376 1844 23533 3836 5468 5579 4821 6777 407040 9134 6774 57715 53842 5534 5578 4090 1365 8976 8526 6654 810 1612 10910 5333 658 90952 60 6722 3690 1870 1482 2787 9071 2790 85015 5332 10686 4628 5159 2767 10507 PMC7721612__F9 RNA sequencing analyses reveal differentially expressed genes and pathways as Notch2 targets in B-cell lymphoma 4049 7186 1439 1843 7124 57521 3297 2475 4792 5290 8503 3320 5533 9844 2534 613 9047 3725 8440 10006 2353 4688 5530 4772 6714 2535 51701 PMC7722191__F1 Action of novel therapies in ET and PV 4352 2056 3716 PMC7722981__F2 Type 1 diabetes mellitus as a disease of the Beta-cell (do not blame the immune system?) 7097 4615 7099 54106 7098 22926 3651 3659 6772 3627 3553 PMC7724774__F1 PD-L1 expression through NFKB 4582 1956 3466 PMC7726326__F7 Gene interaction network of upregulated and downregulated DEGs in TP-treated PC1 (A,B, respectively) and PC2 cells (C,D, respectively) identified by STRING software using a high confidence interaction score (0.700) 5327 2774 2354 64946 5552 64105 401541 63967 47 4171 54962 4060 6713 51514 2331 230 2247 3070 4839 2521 10682 4312 1718 4314 2224 PMC7727076__F6 p53 signal pathway and cell cycle pathway regulated by CDK1 and CCNA2 in pancreatic adenocarcinoma (PAAD) 1019 1017 1039 472 545 2241 637 842 836 4193 64065 84883 7249 5728 6477 64326 23063 6502 9184 5111 4661 23632 10926 PMC7728070__F3 Modulating the autophagic machinery in vascular calcification 3065 8473 282 2475 664 PMC7729087__F4 Aminoacyl-tRNA synthetases and potential therapeutic applications 355 1004 9242 9255 7965 PMC7730176__F3 Estrogen and anti-estrogen signaling in glioblastoma 8205 2475 6774 7018 PMC7730311__F1 Immune interaction and metabolic character of tumor cells and the mechanism of immune checkpoint inhibitor and metabolic intervention 324 941 942 6566 6510 9194 3939 51548 3091 PMC7730978__F1 Gain of function (GOF) effect of mutant p53 and regulation of autophagy by p53 in nucleus 5300 5371 4193 5728 581 7249 2475 PMC7738628__F6 “Synaptogenesis signaling” seIPA-path schematic representation in HI exposed P5 (upper panel) and P10 brains (lower panel) 23025 815 594855 9369 1006 6857 1010 2890 1969 2892 468 2475 1978 10125 2918 1173 6854 1005 1009 134957 1949 816 4915 2902 2049 2044 2891 2904 3708 4137 51655 PMC7738881__F8 Schematic model depicting how 14-3-3σ performs anoikis resistance effects in HCC 1956 1950 836 PMC7744297__F4 Simplified representation of the AChR pentamer and the N-glycosylation pathway of proteins and CMS-related genes (red color) 2673 29925 440138 79868 85365 1798 29880 22845 91869 8818 8813 54344 29929 79087 10195 84920 PMC7744330__F3 Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization 8074 4628 6696 5741 140766 5167 84570 26253 353500 1758 4773 860 651 4041 4313 5764 4638 7058 1303 7480 22801 51384 63923 84624 4323 7077 1281 23768 7148 7059 148113 5727 1307 10631 1293 PMC7746424__F2 Immunomodulation and cell apoptosis induced by the dopamine pathway 1812 1813 1410 6774 2932 PMC7746821__F1 Summary of drug resistance in tumor immunotherapy 7124 8205 3902 201633 55193 472 5771 961 100133941 PMC7746852__F2 Alteration of host signaling pathways by HIV-1 355 7852 1234 920 114548 8717 8772 PMC7748218__F6 Model showing contribution of CXCR6-CXCL16 axis in overcoming the effect of DTX: 58191 10663 102 2932 1499 572 6774 7040 1950 55364 PMC7749079__F1 Hippo signaling in embryogenesis and development 6714 6010 4485 154796 9113 26524 9686 60485 PMC7749645__F1 Convergent type I interferon and proinflammatory cytokine pathways shared between SLE and COVID-19 51284 4615 3654 3656 7187 7189 29110 3665 6772 6773 3661 3659 PMC7750537__F5 Crosstalk of the coagulation cascade and autophagy pathway in cancer cells 8205 7018 9140 3553 PMC7750537__F6 Crosstalk between the coagulation cascade and autophagy on tumor-associated endothelial cells 2308 1003 8678 22863 PMC7750705__F1 Roles of MGO in modulating cell signaling pathways, host immunity, and antiviral activity 581 3099 1878 8178 PMC7752511__F1 Oxidative Stress, Nutrition and Cancer: Friends or Foes? 9242 100133941 947 650 652 2255 26291 PMC7753765__F3 Viruses join the circular RNA world 100500909 286827 100616495 7098 100500909 100616495 286827 7098 PMC7754005__F2 Up‐regulated differentially expressed genes participated in PPAR signalling pathway. Red: up‐regulated differentially expressed genes; green: ppar signalling pathway genes 335 5360 4023 1376 7350 3611 7316 364 PMC7754005__F3 Down‐regulated differentially expressed genes participated in PI3K‐Akt signalling pathway. Red: differentially expressed genes down‐regulated; green: PI3K‐Akt signalling pathway gene 2475 1977 7249 6009 5879 613 5934 5728 572 150365 6256 4193 PMC7754013__F1 MicroRNAs in osteogenic transdifferentiation of VSMCs 407034 3481 7477 142891 389432 90378 3066 4488 860 9759 56998 92 10014 100422910 100616250 388 55576 PMC7755393__F10 Oxidant quenching cycle drives the proton leak in MS-275-treated adipocytes 95 1374 1376 51077 7350 34 35 33 1892 6648 3033 2876 10449 25824 10935 PMC7757044__F1 Roles of related miRNAs during the phases of autophagy 10533 9140 9474 693215 83734 7405 284424 55626 64422 3920 2475 8408 9706 9776 60673 6845 8673 55014 23411 PMC7757045__F4 LncRNA Regulates HCC Invasion and Progression by Modulating Tumor Immune Escape 1956 400550 3932 4616 PMC7759681__F3 Function enrichment analysis of survival-related DEGs in STAD 471 6651 955 221178 10723 5153 401474 5997 84930 64321 10800 6036 1945 284403 1843 3815 4828 23194 993 7538 3955 6929 23178 23220 27161 899 7027 2690 2167 10721 51226 7031 7032 948 6358 9725 9934 23136 56992 6359 80071 4436 5208 51460 8438 10460 80320 11113 3619 29128 4171 63967 80018 352909 10309 55920 347240 80010 79829 5426 55026 8787 27063 80174 8458 84823 27085 1036 22915 286097 199953 116362 835 339451 PMC7759910__F2 SRC kinase during platelet activation 6850 1445 5908 2885 7414 5829 7094 5336 PMC7760552__F2 Release of TEX and their molecular cargo composition 967 928 6010 999 4017 3484 3486 3488 960 PMC7760708__F6 Top two signaling pathways regulated by miR-215-5p in CRC 960 7450 1101 1758 948 1832 961 387 7408 3611 5728 2534 3725 PMC7760785__F2 Crosstalk between the major signaling pathway regulating autophagy and liver tumorigenesis 7124 324 5728 5163 2932 10533 8408 7249 7248 6009 64798 664 PMC7761462__F1 Angiogenesis-related functions of the Wnt/Beta-catenin signaling pathway in colorectal cancer (CRC) 324 3091 1499 4041 7052 5228 1003 PMC7761926__F1 General view of canonical and non-canonical Wnt signaling 8549 4040 4041 4920 4919 84133 54894 23002 5879 2932 1499 387 998 1386 3725 324 PMC7762471__F7 Mechanism underlying ISO’s anti-HCC effects 9474 581 2475 619501 PMC7762563__F2 Angiopoietin–TIE signaling pathway in the vascular endothelium 6010 2308 7075 PMC7762563__F3 Ang-TIE therapeutics against diabetic retinal diseases 6010 2308 7075 7422 PMC7763666__F5 Wingless-type (WNT) signaling pathway 6714 3611 10454 324 4193 51701 3065 3725 6422 22943 PMC7764399__F2 Various gut microbial stimuli due to dysbiosis can cause the initiation of inflammation in the intestine 114548 7054 920 149233 7045 5771 581 64170 345611 PMC7764689__F3 Ingenuity pathway analysis (IPA) network analysis of the modified proteins in response to BK 48 h stimulation relative to control in RASMC 6194 3837 7431 5829 3315 858 1509 3371 PMC7765095__F2 KEGG GO pathways of selected apple Full-length cDNA OvereXpressing (FOX) Arabidopsis mutant lines 4117 1407 1429 1999 PMC7765482__F8 Canonical pathways identified from protein co-expression network 6622 11315 6714 596 1356 27230 1000 6416 5170 4067 638 7040 330 5594 5579 2885 4139 7334 9099 64109 84868 3459 3454 5578 5580 PMC7769847__F2 Schematic summary of Osx’s mission in the complex communications among different bone cells and its potential role in bone micro-environment 4322 9049 4772 4318 50964 1758 5251 1277 PMC7774512__F3 Working hypothesis of Glial Molecular Mechanisms Implicated in the Pathogenesis of POI 3603 3553 6285 5465 PMC7779278__F1 Pivotal role of pyruvate dehydrogenase kinase 4 (PDK4) in regulating the metabolic switch between glucose and fatty acid oxidation in skeletal muscle in physiological and pathological conditions 3667 948 95 2308 5132 5166 PMC7779278__F3 Pyruvate dehydrogenase kinase (PDK) in immune cell metabolism 941 942 948 95 5132 3091 920 PMC7779440__F3 TNF Signaling Pathway (Retrieved from KEGG) as One of the Pathways of Brazilin Targets in Metastatic Breast Cancer 7124 8772 836 83737 3976 4703 4311 4323 6401 PMC7779530__F2 TGFB signaling 4088 4089 4087 4092 3611 PMC7780046__F1 N‐myc downstream‐regulated gene 2 (NDRG2) is a key regulator of cellular stress responses 5728 57447 10419 PMC7780046__F3 Nuclear factor kappa B (NF‐KB) signaling by N‐myc downstream‐regulated gene 2 (NDRG2)/protein phosphatase 2A (PP2A) complex 4055 958 5728 57447 5970 5971 PMC7783665__F4 Calcineurin activation by cAMP/PKA and interaction with CaM for cell secretion 7450 6281 1080 302 PMC7785591__F1 Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway 1499 4041 4040 6647 PMC7785707__F7 Proposed molecular mechanisms 84232 114548 596 79792 PMC7789127__F1 Dual-specificity tyrosine-regulated kinase 1B expression and activity 3845 6010 2475 6018 9149 PMC7789326__F4 SHMOs exerting anti-inflammatory effects in NEC 7099 114548 3553 3569 PMC7792133__F3 PI3K-AKT-mTOR inhibitors and CDK4/6 inhibitors orchestrate multiple effects on immune cells in the tumor immune microenvironment 2475 1021 1019 PMC7793976__F1 Action of emapalumab 3717 3716 6772 PMC7795223__F1 Transcriptional AHR Signaling Pathway 196 6714 9049 405 1545 PMC7795602__F1 Regulatory functions of Mediator complex in biotic and abiotic stress responses 9968 9969 1024 PMC7796305__F2 Complex network of interplayed cellular and molecular mechanisms that participle in the development of myocardial fibrosis leading to the occurrence of dystrophin-deficient cardiomyopathy 4089 4088 7939 5266 1636 100187761 PMC7797476__F4 CILP function and regulation in NP cells by TGFB and IGF-1 3479 8483 3712 4087 4088 PMC7797856__F5 Six core genes (COMP, SPP1, COL1A1, IL6, VWF, TEK) were significantly enriched in the PI3K-Akt signaling pathway 2475 1977 7248 7249 1975 2885 672 3667 613 6850 930 595 11140 5934 5728 66037 572 4193 PMC7798029__F1 Suppressive activity of MDSCs induced by the TLR2 and TLR4 signaling pathways 4352 6275 7097 7099 4615 3716 6774 383 6279 PMC7802183__F7 As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway 23057 8707 84654 79608 1268 8620 2494 256051 4068 205 127833 221044 4026 5999 57097 1476 441272 55970 113828 7157 11258 1669 55698 7571 5581 388662 2006 3651 286411 494197 1181 128506 55520 91937 1622 54622 3444 3451 2091 90011 5079 7179 56108 26060 57689 8479 350 4714 56987 440107 PMC7804490__F2 T cell signaling by E3 ligases and DUBs 940 27040 81545 55611 7535 5163 998 1540 2308 7248 57162 4193 9958 PMC7811571__F2 Main TLR4 signalling pathways 7099 3929 4118 4615 7189 23118 257397 7187 29110 3661 3553 PMC7812258__F1 Non‐canonical functions of TLRs 7097 7099 51284 51311 54106 9474 100653365 PMC7813598__F9 The inhibitory effect of black radish extract (BRE) in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells 3717 6774 9817 3553 468 PMC7816003__F1 Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1A signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats 7019 4899 7351 PMC7817290__F1 The effects of hypoxia on BMSC senescence 2475 4282 23314 PMC7819563__F2 Metabolic alterations in hepatocarcinoma 79004 3939 7086 5019 PMC7821221__F1 Wnt5a exerts its intracellular effects by activating two non-canonical Wnt signaling pathways, or the interplay with the canonical Wnt signaling pathway 89780 7474 4040 4041 4920 324 1499 PMC7824309__F3 Pathway enrichment analysis 10400 1950 59330 PMC7824874__F3 The IRF3 signaling pathway by the UPS following LPS exposure 1540 23220 29110 5987 3661 6737 3627 PMC7827494__F2 Notch crosstalk with other signaling pathways 11319 4040 4041 387 1499 3280 23462 23493 1000 4089 2735 999 3091 6608 6469 PMC7830227__F2 Targeting the Hippo signaling pathway 4485 9113 23476 1025 PMC7830467__F1 Ubiquitin signaling in the tumor microenvironment (TME) 999 4313 8205 PMC7830632__F2 Response model of Ras/phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR pathway to the growth factors, amino acids and glucose levels 5728 2475 253260 5163 3667 1892 23677 6009 1977 PMC7831924__F1 Canonical Hippo signaling pathway in mammals 6469 60485 4485 9113 26524 558 4609 332 7003 8463 7004 7005 PMC7831924__F2 Modulations of Hippo signaling in gliomas 1956 2932 1786 4734 60485 1499 4485 9113 26524 9820 2475 100422996 9641 51421 9734 23492 7003 145258 PMC7834968__F8 Schematic diagram showing how ASV alleviates silica-induced pulmonary fibrosis by regulating TGFB1/Smads pathway 4087 4088 4089 4092 PMC7835009__F6 VEGFR1-specific signaling pathway that HIF1A participates in 5228 7422 7423 25759 8828 207 23607 5921 5781 3091 5335 3320 867 5595 805 5566 4690 808 5170 PMC7835030__F7 NLRC4 gene regulates inflammatory reaction and immune response of DCs in septic shock by mediating the NLR pathway 941 10392 64127 942 58484 3553 PMC7835541__F3 Effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification 8027 7124 10379 10750 PMC7837452__F5 Iron-Sulfur Cluster Biogenesis, Trafficking, and Signaling: Roles for CGFS Glutaredoxins and BolA Proteins 7523 27247 200205 PMC7838823__F4 Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses 7018 4297 4860 191 100 136 7528 2770 2678 3725 2099 10000 4792 7525 2752 586 4088 5594 4609 6733 5580 6774 3091 1871 PMC7838888__F1 Representative long non-coding RNAs (lncRNAs) in diffuse large B-cell lymphoma (DLBCL) 4609 286467 378938 138948 84811 84740 652995 100130776 7503 85028 PMC7841890__F4 Activation of the antioxidant signalling pathway by natural remedies against polyQ-induced SCA 54205 2729 2950 6648 PMC7842149__F3 Angiotensin II and T lymphocytes activation during COVID-19 best scenario 7113 7808 6868 7054 PMC7843730__F5 Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome 100187761 7939 7956 5447 1103 1475 100 10750 1130 7454 140821 666 6651 PMC7845572__F2 An overview of cellular metabolic pathways in MM cells 5728 3099 3939 PMC7851309__F8 Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice 1233 7850 1235 4094 6095 50943 5468 4773 2672 3398 6778 84901 5966 8651 55636 3595 3164 3659 7050 3716 11251 8013 PMC7851492__F1 Conflicting metabolic alterations in CSCs 4609 283120 27035 5163 2203 PMC7854989__F2 Novel insights provided by single cell transcriptomics regarding hepatocytes and hepatic NPCs in nomal liver and during various injuries and pathological conditions 5156 6277 1902 3553 6696 54209 928 8742 729230 3958 4283 2167 948 650 7422 8829 6280 6279 4804 PMC7856191__F8 Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways. 126669 613 717 57823 933 PMC7856198__F5 Gene identification and pathway Network Analyses of the IL-4R responsive transcripts in the metabolic MMC9 cluster 7054 4175 100507436 978 7846 51234 23326 10797 7298 1736 54962 64969 2585 4351 22852 6183 29108 92259 PMC7856673__F1 Current model of LOX-1-dependent signal transduction 9475 9138 387 6714 2920 7412 3383 PMC7858612__F3 Ferroptosis: mechanisms and links with diseases 2879 7296 2937 2936 3652 3156 PMC7859329__F2 Thyroid hormones, Wnt pathway, and miRNAs crosstalk 1499 27121 9969 406990 PMC7859453__F3 Activation of ERBB family receptors by growth factors can activate RAS MAPK signaling 4018 374 2069 1950 6010 PMC7862069__F3 Inhibitors targeting Bruton’s tyrosine kinase in cancers: drug development advances 613 930 921 7852 4615 4067 6850 973 974 695 29760 8915 4609 PMC7862327__F3 PI3K–AKT–mTOR signaling cascade and other related pathways involved in FCD 2885 3667 5728 5170 5900 7248 7249 5337 6009 64798 9681 10641 8131 1977 3643 3362 PMC7864218__F3 Intersection of Mechanotransduction and Regenerative Osteogenic Materials 1499 324 387 51701 998 PMC7864517__F2 In the absence of Hedgehog (HH) ligand (SHH, IHH, and DHH), the Patched 1 (PTCH) transmembrane receptor at the base of the primary cilium maintains inhibition of Smoothened (SMO) G protein coupled receptor (GPCR) signaling 6608 6469 374654 2735 2737 2736 51684 596 7424 117581 79923 6657 PMC7864817__F1 Metabolic changes induced by DOXO in cardiomyocytes 3667 208 207 2475 8408 596 PMC7865460__F1 Multiple myeloma (MM) cell metabolism compared to normal plasma cells 3939 3945 952 PMC7866294__F1 Cellular ganglioside metabolism and structure of GD2 51083 7357 51046 2583 8705 PMC7867260__F3 Gluconeogenesis and other rescue pathways for the generation of metabolic intermediates in low-glucose conditions 2203 5106 5105 PMC7869020__F5 Regulation of de novo Purine Biosynthesis and Purinosome Formation 6790 5581 5471 5198 10606 471 158 9212 472 545 PMC7870526__F2 Metabolic regulation of lung myofibroblast activation 2147 3099 26227 5163 2744 6510 29968 5723 6472 PMC7871366__F2 IBD genes and pathways controlling mucosal immunity 5734 4485 159296 2494 63027 2646 3083 84870 3172 196 27035 54546 2524 120400 91869 64116 57222 55054 120892 8477 55876 4210 144811 958 10320 639 4843 4689 8935 60468 113 4088 3586 5579 7128 23118 201266 3559 221895 8204 3717 9817 10125 26191 8767 7084 64135 64127 149233 64170 3572 10758 746 6775 6097 3676 3458 940 9966 3593 10019 3685 64167 PMC7871366__F3 Pathway paradigms highlighted by IBD genetics 2212 7124 3553 3458 64135 64170 64127 8767 7128 4210 55054 4843 4689 144811 120892 196 4485 84870 54546 3083 5734 3172 5321 3559 10125 639 60468 6775 26191 940 5008 746 23753 4088 23118 9180 3572 345611 8737 9817 149233 6097 7297 8477 23765 10758 1051 58484 199713 8807 PMC7871890__F1 Type I and III interferons response following SARS-CoV-2 sensing during controlled (left and central cell) and uncontrolled (right cell) infection 3454 3455 163702 59272 3716 7297 6772 6773 51284 57506 4615 29110 3659 3661 3553 PMC7873566__F3 Formation of the signaling-competent IL-1R complex and downstream IL-1 signaling 3554 7850 54472 7189 10454 3654 257397 23118 51135 7316 3656 7124 3576 5743 PMC7873896__F2 Wnt signaling pathways at the plasma membrane 4040 4041 999 54894 8549 1499 5218 2932 324 6259 22881 PMC7873978__F1 Lipoic acid metabolism pathways in E 3989 3988 340654 4967 PMC7874053__F4 Ingenuity Pathway Analysis (IPA) results for candidate genes of LGS or LGS-like epilepsy 51629 6854 11138 288 5801 1106 5999 85358 3845 10203 115426 23452 9227 6645 594857 10451 9542 286436 53918 6336 151 PMC7875453__F2 BCR signaling pathways 613 971 933 6714 6850 5336 29760 695 5163 8915 10892 7186 7189 3398 5970 2002 4790 PMC7878388__F1 HSV manipulations on the cytosolic pattern recognition receptors 9447 115004 3428 57506 29110 1499 PMC7878670__F2 IGF-1R trafficking routes and signaling to the mitochondria and from the Golgi and the Nucleus 3667 5903 3480 3725 6591 51176 595 8313 2932 664 3479 999 PMC7880238__F2 Proposed strategies and small molecules (direct and indirect) that could promote or inhibit YAP/TAZ activity 6714 5596 4485 8491 11183 9448 11184 5871 154796 387 26524 9113 81788 761 9686 PMC7880431__F1 Anti-epileptic drug topiramate upregulates TGFB1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity 10220 124857 3339 2660 7484 7043 5340 3714 1280 7077 7040 1906 6469 652 2049 1947 2263 92 7301 3696 1739 7048 4040 2048 5979 2260 2619 6259 2155 4642 1956 5156 1595 7314 9420 1398 6647 1147 8717 1717 51141 26035 2571 131 7137 6885 10054 283120 1801 116039 2932 5887 5308 1789 196 6591 145258 6615 1028 1719 4487 8092 25806 8626 9343 4335 3664 2303 6949 5087 7341 56033 11200 6899 5089 2637 8317 23314 1745 4194 6500 1911 60529 79035 PMC7880682__F6 Effect of curcumin mediated by PPARa in mouse liver 5465 729 30 PMC7881844__F2 Loss-of-function (LOF) mutations in components of the insulin signaling pathway found in patients with syndromes characterized by severe insulin resistance 3643 208 3667 8660 5163 5164 5506 9882 2308 PMC7882619__F2 Irisin: A New Code Uncover the Relationship of Skeletal Muscle and Cardiovascular Health During Exercise 581 2475 3383 7412 PMC7883599__F4 SIRT1 and SIRT2 in Huntington’s disease 627 23411 7350 22933 PMC7884371__F2 The NLRP3 inflammasome pathway 7124 4615 8772 64127 114548 79792 3553 8737 PMC7885061__F2 Altered gene expression profiles and signaling pathways in vitiligo 5291 6198 596 7391 1638 2315 7306 693162 26191 50943 7124 5132 PMC7885480__F1 Developmental signaling that govern CSCs and therapy resistance 6469 6608 5727 4763 4771 60485 51684 4485 11127 324 9113 26524 10413 1499 2737 7003 8463 7004 7005 PMC7886103__F9 Mechanism for protection of MgIG against ATO-treated cardiotoxicity 3603 581 847 7099 PMC7886690__F1 Signaling pathways activated in the unfolded protein response (UPR) 22926 7186 1998 468 PMC7886702__F4 Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions 2308 7127 2633 639 4628 604 5608 185 6772 3394 115362 7453 406947 145864 27161 3929 1435 5551 7124 7157 84959 PMC7886970__F3 CD40/CD40L signal pathways 6714 3718 7189 7185 7186 7187 7188 5971 6774 PMC7887571__F1 a) Schematic illustration of the HCJSP prodrug nanoparticle prepared via the host–guest interaction between HA‐CD and AD‐SS‐JQ1 and AD‐SS‐PPa 3099 3939 23476 PMC7890593__F3 Identifying AKAPs in Cells and Tissues 9733 11083 9092 58517 6651 1665 10523 10973 3185 23451 10569 9972 9967 9774 3619 10432 9493 22974 PMC7890860__F4 Signalling pathway and key factors which regulated the mitochondrial energy metabolism in MSCs 23411 7351 23410 6648 PMC7892797__F1 All detected PLA2/COX pathway genes and regulatory factors and alterations in their transcription levels between patients with schizophrenia and healthy controls 338442 2182 4512 1385 80142 5730 5740 27306 5732 5731 5734 11251 5729 5739 PMC7893122__F1 Hedgehog signaling pathway and representative inhibitors of SMO, GLI and BRD4 6608 5727 51684 23476 2735 2736 2737 595 PMC7897836__F2 Developmental Regulation of GFAP Expression 1270 3976 5008 650 3276 2670 4774 4204 25942 23118 2066 PMC7899164__F6 MitomiRNAs interactions with mitochondrial encoded genes either positive or negative suggestively 406991 4514 4512 4519 4508 PMC7899890__F6 Interaction between tumor necrosis factor and tumor necrosis factor receptor 2 signaling 7124 836 8772 83737 3569 8717 1906 6401 3382 197259 PMC7901191__F9 Wnt signaling pathway associated with FZDs 59352 8549 55366 54894 51701 84133 147111 9350 4040 4041 1499 324 4089 4088 50964 25805 6500 8454 9978 6477 387 23002 9475 27130 6259 PMC7901903__F1 Gasdermins in pore formation and pyroptotic cell death 6010 284110 55876 79792 1687 PMC7902034__F1 Localization, intracellular trafficking, and signaling pathways of nucleic acid-sensing Toll-like receptors (TLRs) 54106 7098 51311 51284 4615 7189 7187 29110 3661 81622 3665 PMC7902901__F3 Merged network of Reactome pathways identified by all models (2.1 to 2.5) 331 95 6464 8178 613 6010 6657 79923 100187761 861 219743 6418 65057 PMC7902901__F5 Induced regulatory network of smooth muscle cell contraction 6722 2002 1387 407008 7169 5728 309 800 4087 4089 8928 1482 7094 4088 6668 6667 6670 2626 PMC7904562__F5 Network of transcriptional NR1I3-mediated response elicited by pesticides (here shown: IMZ) in rat liver, as computed with Ingenuity Pathway Analysis software 5469 2949 1577 1543 2052 1555 351 PMC7904591__F1 Trained Immunity and Reactivity of Macrophages and Endothelial Cells 114548 948 4280 3949 3091 2475 3480 7099 3099 5209 23152 64127 PMC7905011__F7 Changing cell’s redox balance (NAD +/NADH) resulting from lactate conversion to pyruvate augments reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and mature skeletal muscle 2475 83734 9140 10533 64422 PMC7906909__F8 Inhibition of PFKFB3 induces cell death and synergistically enhances chemosensitivity in endometrial cancer 5209 2147 5888 2475 581 PMC7910460__F4 Crosstalk between HIFs and mitochondrial dysfunctions in cancer development 7038 5465 6472 406992 4862 9927 65018 23462 4601 7428 PMC7911116__F2 Lithium interactions with oxidative stress, inflammation and glutamatergic pathways 596 627 2932 PMC7911386__F2 Signaling pathways of obese/T2D cell, of critical COVID-19 cases 59272 51311 51284 3665 4615 3656 1401 6347 3553 114548 1958 581 PMC7911475__F2 Mechanism through which flavonoids induce cancer cell autophagy 619501 6774 1636 2638 PMC7912342__F6 CGAS-STING signaling pathway 619537 115004 3661 PMC7912637__F6 Mechanistic diagram for microglial IRF5/4 activation 3565 7099 3566 3662 4615 3663 383 51135 7189 PMC7913544__F2 Functional roles of E3 ubiquitin ligases (blue) and DUBs (pink) in the ER stress and ERAD signaling pathway 8078 10869 22926 9097 83939 55432 8266 468 8975 8314 662 138065 54546 PMC7915189__F2 Some examples of signaling pathways involved in OS resistant tumor cells to conventional treatment 81861 100499166 2932 1499 5728 2475 PMC7916866__F1 Oxidative Stress, Plant Natural Antioxidants, and Obesity 181 4852 3479 3480 3667 PMC7917047__F5 Possible signaling pathway of MbovP280-induced apoptosis in BoMac 581 1410 842 836 351 PMC7917224__F8 Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload 9759 2932 2626 PMC7917472__F4 PI3K-Akt signaling pathway regulated by EZP 2475 1977 7249 5894 2444 613 6850 930 5934 5728 572 150365 6256 256933 4193 PMC7918750__F3 Human cytomegalovirus (HCMV) factors that contribute to latency maintenance 947 91 4664 4088 3569 387 PMC7919196__F2 Pathogenesis of COVID-19, showing the involvement of components of the fibrinolytic system in various steps 1636 59272 5340 7113 PMC7921060__F6 BMP/Hippo signaling modulating VEGFR pathway and angiogenic phenotype of endothelial cells 650 654 54567 374 6591 PMC7922062__F3 Glycan-lectin interactions within the breast cancer microenvironment modulate the phenotype of tumour-associated macrophages 9332 6369 6374 51083 PMC7922220__F1 GnRH-I receptor signaling in ovarian cancer cells 1950 1956 8205 6714 2885 3727 6722 PMC7924562__F1 Momelotinib and CFM4.16 synergistic combination 6774 983 991 PMC7926043__F8 Mapped proteins and genes in the glucocorticoid receptor signaling pathway, the role of JAK2 in the hormone-like cytokine signaling pathway, and the TNFR1 signaling pathway 2289 3716 7124 29949 6776 3717 7186 836 5781 PMC7927137__F5 Circadian clock machinery regulates the biosynthesis of NAD+ through control of the NAD+ salvage pathway 10135 23411 406 9575 PMC7932549__F2 Overexpression of DNA repair genes in invasive ductal and lobular breast carcinomas: Insights on individual variations and precision medicine 353497 9768 56655 5983 5111 7316 9636 5426 57599 7318 55215 6118 199990 51426 55120 84126 545 5984 378708 6117 2176 5425 2178 51514 84464 2175 201254 2072 146956 2189 5429 57697 9978 91442 197342 23514 7415 7314 8914 641 472 4350 8930 3364 4683 4968 2138 328 5981 7341 2139 5982 7468 7515 25 3978 3838 5423 6996 11200 8505 11284 51588 9656 7014 4361 79184 580 7157 9577 26277 65057 PMC7933474__F1 Schematic diagram depicting a proposal model of the complex relationship between autophagy and exosomes in the context of pancreas ductal adenocarcinoma (PDAC) and its environment 100302158 4318 8754 94241 55801 6648 847 1633 PMC7933493__F1 Retinoid cycle of retina 6121 9227 6120 PMC7933806__F2 Sphingolipid networks 1674 6611 4026 64781 PMC7934645__F3 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases 374654 6608 51684 8452 2295 8405 PMC7934813__F2 Central role of ACE 2 in SARS-CoV-2 infection and COVID-19 severity 7808 7113 59272 1636 545 PMC7935273__F8 GABA/Beta-glucan supplements on melatonin and serotonin content extracted from natural resources 8462 2308 6667 PMC7935942__F5 Expanding the drug discovery space with predicted metabolite–target interactions 847 3605 7077 5331 151306 5778 PMC7937699__F2 From Melanoma Development to RNA-Modified Dendritic Cell Vaccines: Highlighting the Lessons From the Past 2475 940 942 941 PMC7937869__F7 Coronavirus N protein inhibiting IFNB production 7706 100187761 7187 29110 3661 PMC7939748__F2 Molecular mechanisms of plant-based foods in the alleviation of NAFLD 9817 23410 2475 355 PMC7940537__F1 MTORC1 signaling and glycolysis pathways 2475 64798 1977 PMC7945298__F8 Subnetwork of PVT1 and HOTAIR 10220 5328 9526 64393 7022 57532 595 6650 2152 27242 56172 23650 1786 9262 5738 5925 5361 100124700 7803 6498 5476 122786 3091 55165 1869 63027 1026 3720 5820 6241 283373 3149 9764 6659 10036 5054 51148 3984 90007 24147 56675 4313 1844 5069 55357 3838 7422 2799 19 57826 PMC7945298__F9 NcRNAs involved the PI3K-Akt signaling pathway 100124700 5820 1277 1290 7422 7249 7248 1026 6009 64223 57521 2475 1869 1977 PMC7954711__F1 The B6 vitamers pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM) and the respective phosphate esters pyridoxal-5′-phosphate (PLP), pyridoxine-5′-phosphate (PNP) and pyridoxamine-5′-phosphate (PMP) 5091 4860 8566 3651 PMC7956553__F3 Simplified cartoon of potential crosstalk between activated canonical Wnt/Beta-catenin and mTORC1 pathways 2932 1499 847 1977 7248 2475 PMC7957022__F3 CAFs drive resistance-related paracrine pathways in the TME 3486 6781 3082 6774 51135 540 538 3553 2250 6469 PMC7957022__F5 Main signaling pathways responsible for therapeutic resistance mediated by the tumor environment 3845 7189 3939 6774 2475 PMC7957534__F3 Role and regulation of CTHRC1 in canonical and noncanonical Wnt signaling 4920 115908 23002 387 5879 324 1499 1798 PMC7959691__F4 PTP regulation of adhesion complexes and related pathways 5795 4485 5777 9113 26524 5783 5784 11099 7204 5792 6714 8412 2885 5786 PMC7960990__F6 Importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation 11113 1674 7054 146956 PMC7961479__F2 Activating mutations and activation of alternative upstream receptors confer resistance to inhibitors targeting aberrant MAPK signaling 673 5879 7249 6009 2475 PMC7961479__F3 MAPK, PI3K, and angiogenic reactivation confers resistance to c-KIT and VEGFR TKIs 4881 7249 6009 2475 PMC7961492__F1 Mechanisms and molecules involved in cholesterol metabolism and homeostasis and the regulatory effects of Non-encoding RNAs are depicted in a foam cell 4023 406924 344 407039 1030 39 PMC7961658__F7 Possible mechanism of action of glycyrrhizin (GL) in colon cancer 7099 4615 3146 3570 6774 6662 PMC7965690__F4 How MARylation is predicted to be involved in the regulation of colorectal cancer 999 1499 2932 324 196 3837 140733 PMC7966921__F3 Myristoylation in regulating TRIF-related adaptor molecule (TRAM) during LPS-induced TLR4 inflammatory responses 7099 4118 4615 3661 PMC7966997__F1 EGFR pathway (Qiagen Pathway Central) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) 1956 4200 5897 7975 348 PMC7966997__F2 EGFR pathway (Biocarta) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) 1956 1950 5290 2885 6464 50964 3265 5578 6774 5579 6416 PMC7967218__F2 Histone acetylation regulates genes involved in cancer progression 3065 6608 2735 2294 648 7048 999 2099 4088 6768 4087 4072 54845 57111 PMC7970140__F2 Abnormal metabolic pathways 2194 3939 3099 3945 2023 47 5315 3417 5236 2821 55276 5160 1738 2744 5214 5091 2597 50 5106 5211 4200 1431 3418 2746 230 4191 2806 7167 440 226 4967 2271 6389 8801 6390 9123 PMC7970560__F11 Modulating the PI3K-Akt signaling pathway and MAPK signaling pathway of ginseng against ALI/ARDS 4208 8717 7124 4149 7186 7189 4615 51701 3727 2885 7097 7099 5879 613 6850 595 930 572 4193 PMC7973386__F1 Representation of NAD+biosynthesis pathways 51547 23411 51548 10135 93100 349565 23410 23409 23408 PMC7974548__F3 Mechanisms of cardiotoxicityAbnormalities in action potential duration or conduction velocity are associated with a direct block of ionic currents or inhibition of their trafficking from nucleus to cell membrane 3382 9118 1956 7124 PMC7976584__F6 MiR-362-driven TGFB/SMAD signaling modulation of cell migration and invasion: a proposed scheme 1602 4087 4089 6615 PMC7981155__F2 WNT5a in Colorectal Cancer: Research Progress and Challenges 4041 4040 7474 6010 1499 324 4920 PMC7982593__F7 Graph abstract HCC manifestation is typically preceded by hepatic fibrosis and cirrhosis 619501 4092 4087 4088 4485 26524 4089 100188857 2246 4609 PMC7982967__F2 Mechanistic actions of Ca2+ during myofibroblast differentiation 7048 7046 59341 7225 54822 7222 1277 PMC7985550__F3 PI3K signaling pathway and related target drugs in vascular smooth muscle cells 3479 3630 860 652 2309 5728 PMC7986695__F2 Crucial cells and molecules involved in postsynaptic responses in the regenerative niche at the vertebrate neuromuscular junction (NMJ) 4314 4038 4593 285489 PMC7988095__F2 AhR signaling pathway 196 57491 405 PMC7990776__F2 BRD4 in innate immunity 3606 3146 7096 79792 4615 115004 7098 8517 1147 3551 838 837 340061 4792 114548 5970 7124 3553 3569 29110 3661 1025 23476 834 PMC7991574__F6 The used inhibitors and the signal transduction pathways involved in BDNF and C3 effects on SGN 718 387 627 PMC7991810__F2 Signaling cascade of NC1-peptide that regulates spermatogenesis 2475 6194 207 208 998 2059 PMC7996143__F11 Activation of Sirt1 with SRT1720 can handle the high fructose diet-induced insulin resistance, oxidative stress, and mitochondrial dysfunction through Sirt1-PGC-1Alpha-NRF1- Sirt3-TFAM signaling pathway 7019 23410 4899 PMC7996871__F2 PERK pathway and small molecule modulators 9817 54870 468 23621 PMC7998946__F2 Metabolism of activated T cell and the effect of cancer-induced tumor microenvironment (TME) acidification on T cell response 3099 226 2597 920 3939 PMC8000126__F7 TR-dependent regulation of genes in the Wnt signaling pathway, a representative pathway likely involved in the development of adult intestinal stem cells, as revealed by RNA-seq analysis 51701 147111 9350 4089 324 50964 25805 6477 6500 8454 387 6259 9978 23002 27130 6957 6955 PMC8000263__F2 Lipid metabolic pathways that regulate ferroptosis 948 9415 2194 2717 1896 4553 3992 2181 2879 5037 60481 54898 2182 10162 100 PMC8000754__F4 Proteasome inhibitors and metabolic pathways 3091 3939 468 10135 3418 23410 PMC8001214__F3 Mechanisms of aging-associated salt-sensitive hypertension and crosstalk between Wnt noncanonical pathway and angiotensin II (Ang II)-induced vasoconstrictive pathway 3553 387 1499 7175 4040 4041 4920 PMC8002322__F2 Targeted therapies directed at cell cycle and DNA damage repair pathways 595 545 472 6741 672 PMC8002454__F1 Rheb-mTORC1 signaling pathway in neurodegeneration 51256 7248 7249 6009 2475 64223 8408 23621 PMC8003366__F1 View at a glance of the landscape of the metabolic interactions between genes and pathways discussed in the manuscript 581 3418 3417 54790 PMC8004172__F2 Molecular components of the host contributing to the modulation of the immune response during human metapneumovirus (hMPV) infection 7099 4615 114609 10410 7189 3902 10454 257397 51135 3665 7187 51284 10010 7098 29110 3661 PMC8005405__F2 Mechanisms regulating ROS in LSCs 7173 51024 6648 PMC8005494__F2 Molecular mechanism of pyroptosis 3002 3001 6774 55876 79792 56169 1687 3146 PMC8008022__F3 Apoptosis is triggered through two major pathways referred to as the intrinsic and extrinsic pathways 7099 8737 8772 8717 638 27429 7098 836 637 24145 8756 102 PMC8016624__F4 miRNAs involved in the autophagy pathways 64223 2475 847 1998 83939 693215 9140 PMC8016635__F3 Impact of PERK signalling activation on osteoclastogenesis 5879 83939 4772 468 PMC8016635__F1 Brief diagram of the PERK signalling pathway 9817 83939 2308 3643 2475 2729 468 10533 PMC8017943__F4 GA biosynthesis and isoprenoid pathway mRNAs in SRB suspensor and embryo proper regions 100188011 23179 5863 PMC8022592__F5 Differential regulation of breast cancer cell growth by methyljasmonate (MeJA) or MeJA‐treated leaf disks 896 595 990 898 1017 898 896 595 1017 990 PMC8023019__F1 Rationale for the combined use of an ICD inducer and an IDO-1 inhibitor 3146 324 1998 2475 196 PMC8026611__F2 Ferroptosis: molecular mechanisms and health implications 7018 4057 51199 8031 55240 875 27165 2495 2729 2512 1491 2805 4891 7417 7419 2539 2937 31 7879 3156 2194 2879 2222 6713 7295 100 7163 857 2182 4843 51510 10162 2643 79643 5447 84883 5192 8504 23657 6520 1803 81539 6510 7037 30061 PMC8026611__F5 Ferroptosis: molecular mechanisms and health implications 4780 9817 2936 23657 2937 2730 2729 4094 2879 218 3162 4495 2512 2495 2235 30061 PMC8026611__F7 Ferroptosis: molecular mechanisms and health implications 9474 3458 5873 3460 3459 6772 177 23657 6774 3586 383 7040 2879 3716 3717 6520 PMC8026947__F3 Unfolded Protein Response Pathway 2923 10954 22926 10130 83939 7494 468 PMC8027469__F2 Investigating the Underlying Mechanisms of Circular RNAs and Their Application in Clinical Research of Cervical Cancer 1956 3688 442906 8663 207 9444 5894 102466271 100616408 406942 5111 4193 999 2002 4194 4088 4089 PMC8032984__F2 B7-H3 increases ROS and HIF-1A through B7-H3-induced Nrf2 suppression, SOD1, SOD2, and PRX3 reduction, thus promote aerobic glycolysis in cancer cells, leading to tumor growth 324 6647 6648 7040 920 27250 2475 PMC8034539__F2 Schematic models of BMP7 and TGFB signaling pathways in thermogenesis 655 4090 4086 4087 4088 4513 80326 PMC8034938__F7 Celecoxib attenuated ZD-promoted tumorigenesis through suppressing inflammations 3603 5266 1499 6374 2920 PMC8035741__F5 Graphical representation of the potential apoptotic pathway induced by the Human-RPSA siRNA in late (DLD-1) stage colorectal cancer cell 10940 662 581 472 3014 1499 27250 PMC8036441__F5 Quercetin apoptotic mechanism via death ligand and mitochondrial membrane 581 572 4513 PMC8036595__F7 Mg2+ and Gd3+ interfere with phosphate-induced SOCE upregulation by the activation of CaSR in megakaryocytes—a schematic representation 846 84876 10725 6446 6786 PMC8036642__F3 MicroRNAs, Long Non-Coding RNAs, and Circular RNAs: Potential Biomarkers and Therapeutic Targets in Pheochromocytoma/Paraganglioma 5728 5163 652995 55553 7249 7248 6009 5795 7049 PMC8036776__F1 NF-kB pathway targeted by GSH 3569 3553 3383 4513 PMC8036803__F2 Msi1 impact on cell cycle and division 2146 113130 79968 5932 8438 10274 54892 675 8243 7153 9700 64151 6117 2177 23310 5591 641 64858 63967 10051 6241 672 6119 332 11335 11073 2956 8914 5499 55872 157570 84515 4171 8318 1407 3619 1111 990 8317 10383 7280 9133 6790 1763 2237 11169 55755 1017 4173 9134 79915 81620 5422 5983 1870 10376 701 994 8900 23649 6839 9055 79866 4085 6502 5557 10714 1062 991 699 11004 5933 7161 4440 146909 11065 3843 890 91768 3837 1104 2260 147841 51203 9126 10735 1874 4087 4089 4193 324 9184 5111 993 983 1022 4661 999 10926 4998 4999 23595 5000 23594 5001 PMC8036928__F3 Antioxidant metabolism in circulating tumour cells (CTC) 1374 3418 4199 4118 PMC8036978__F1 Simplified extrinsic signaling pathway from TNF-R1, Fas, DR4, and DR5 355 8717 7186 637 8772 PMC8038777__F2 Granulocytes role in CRC 383 6348 6351 6359 6280 7124 2056 7908 2919 3553 3458 6356 64806 6369 PMC8039141__F2 The different mechanisms involved in Senescence Associated Secretory Phenotype (SASP) regulation 10758 2626 7189 115004 2475 472 1051 23476 3554 PMC8039382__F2 Metabolic and signaling networks involved in anoikis-resistance mechanism 5728 2475 4609 2194 6774 1956 PMC8040901__F3 Lipid Pathway Enrichment Analysis (LIPEA) has shown that the autophagy pathway is involved in the phosphorylation of exosomes from PC3 and DU-145 cells 2937 6520 2638 2879 10162 2182 100 7018 3652 55240 1356 5094 PMC8040975__F3 TSP1 and ligands in glucose metabolism and diabetes mellitus 948 961 140885 7351 7040 PMC8042281__F3 Histone modifications, dynamically added or removed around the DNA damage site, constitute an integrated signal for the DSBs repair pathway choice 672 51111 84787 9025 165918 387893 26013 9055 7415 9682 3065 3066 4200 4199 3014 22992 10873 6419 54799 79728 580 5888 PMC8042443__F7 A, schematic diagram showing two separate DGKζ signaling complexes, one for Rac1 activation (left) and one for RhoA activation (right) 4018 5879 387 5058 4082 PMC8043250__F1 Top left, in red: NK cells recognize tumor targets that lack MHC, as this prevents the inhibitory response mediated by KIR 1956 8760 7409 5336 10666 56253 201633 10225 4277 100507436 PMC8047536__F3 Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B 3276 9021 8835 4055 3669 3428 1356 PMC8047580__F1 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy 59272 5340 7018 PMC8047580__F2 An Integrated Approach of the Potential Underlying Molecular Mechanistic Paradigms of SARS-CoV-2-Mediated Coagulopathy 3383 7412 7450 7018 PMC8051677__F6 Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties 5160 5106 9123 3939 1938 3418 3417 4191 5315 204 1431 4190 47 3615 4397 2108 50 383 38 3155 6647 84817 11112 6648 7001 10007 9352 10549 25824 847 5052 1512 1509 10539 811 3689 140809 9588 2745 1520 2936 3916 1508 10935 51060 2944 1781 PMC8051751__F6 Molecular mechanisms induced by sirt1 inhibition in ACC cells 3480 1000 581 595 PMC8052156__F6 Active ingredient-target-pathway network 4314 4170 5321 5465 5468 3791 7124 5743 3480 5836 3156 5837 1080 23411 1021 1017 207 PMC8052535__F1 Proteolysis and inflammation of the kidney glomerulus 727 721 720 5648 715 729 717 716 730 735 PMC8055391__F7 Follistatin-Like 1 Attenuation Suppresses Intervertebral Disc Degeneration in Mice through Interacting with TNFA and Smad Signaling Pathway 7124 652 11167 4086 7099 11096 3712 PMC8056081__F2 Diagrams of a hypothesized extreme resistance pathway and its possible relationship to the hypersensitive response 192670 3084 6295 7018 PMC8058464__F1 Transcriptional signature of Leishmania infected macrophage 3565 6778 23411 355 5163 2475 PMC8064175__F5 Sex-specific differences of humoral immunity and transcriptome diversification in older adults vaccinated with inactivated quadrivalent influenza vaccines 4599 3434 3437 8519 3665 128486 10410 11326 7305 720 713 712 710 721 715 714 1401 716 PMC8064670__F1 GM-CSF signaling pathways 3717 5163 3662 5292 5008 PMC8065657__F1 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor signaling in the regulation of apoptosis and metastasis of cancer cells 5879 7186 8737 4312 6714 6774 8772 8877 PMC8066561__F1 DNA double-strand break repair mechanisms and PARP inhibitor function 6741 10111 4361 472 545 580 672 2177 1111 11200 79728 7518 PMC8068170__F1 WNT signaling pathways 4040 4041 324 1499 387 3725 PMC8069635__F3 Immune response pathway of SARS-CoV-2 59272 1636 7113 7113 59272 1636 PMC8070086__F6 Putative mechanisms of TRIB3-mediated AKT signaling inhibition 57761 64223 253260 2475 5163 572 PMC8070110__F2 Schematic diagram of the interconnection between EMT and TRF1/2 4087 4089 4088 4193 4313 7291 7015 25913 999 1000 PMC8070467__F2 Metabolic link between diabetes and cancer 2475 1950 3479 PMC8070500__F2 JNK pathway in CNS pathologies 474168 467 687 4312 PMC8071514__F4 Role of the acetylation pathway in TAp73 regulation 1130 22933 50507 8213 5548 PMC8072221__F12 Expressional and Prognostic Value of S100A16 in Pancreatic Cancer Via Integrated Bioinformatics Analyses 8021 203547 79171 57111 11178 34 1431 1737 6389 39 PMC8073242__F4 Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells 7167 226 3098 5230 2023 3939 2821 2597 5223 5315 1506 3553 2745 PMC8073242__F6 Glutathionylation chemistry promotes interleukin-1 beta-mediated glycolytic reprogramming and pro-inflammatory signaling in lung epithelial cells 3098 2821 7167 5230 226 2023 2597 5315 5223 3939 1506 2745 3553 PMC8073517__F1 Adaptor Protein Myeloid Differentiation 88 (MyD88) in Post-Subarachnoid Hemorrhage Inflammation: A Systematic Review 4615 7189 114609 3661 PMC8076792__F1 Disrupted Lipid Metabolism in Multiple Sclerosis: A Role for Liver X Receptors? 3156 2194 6319 355 3553 6362 1718 4864 10577 9619 19 4397 10858 50943 PMC8079203__F8 PI3K/AKT/mTOR and autophagy signal pathway 2475 9474 4313 4318 PMC8079716__F2 From purines to purinergic signalling: molecular functions and human diseases 5471 5640 471 7808 10606 PMC8080560__F2 Depiction of key proteins targeted by CRLs during cell cycle progression 1021 1019 983 2305 1017 PMC8080639__F1 General unfolded protein response pathway during ER stress 7186 22926 83939 468 7494 PMC8081860__F3 Lipoarabinomannan as a Point-of-Care Assay for Diagnosis of Tuberculosis: How Far Are We to Use It? 7097 114609 4615 834 4088 4067 4353 27074 5873 7124 PMC8082775__F3 Nonsense-mediated RNA decay and its bipolar function in cancer 5976 9020 619501 65110 2735 83939 468 23657 PMC8084697__F1 Type I and III Interferons in COVID-19 59272 7098 51284 51311 7099 4615 57506 7187 29110 3661 3716 6772 7297 6773 10379 91543 9636 PMC8086570__F5 Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses 145258 23774 83988 7157 102465688 56658 114088 10785 9839 117581 114785 PMC8092118__F1 5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent 693197 607 1499 51176 324 51701 79971 1540 9429 4040 4041 5243 648 79923 960 54894 8549 59352 84133 1788 10454 PMC8093649__F3 Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases 23118 7186 81858 8717 10454 8772 197259 PMC8093981__F1 14‐3‐3 proteins in cell signalling pathways and virus infection 993 995 7249 572 PMC8093981__F2 14‐3‐3 proteins in cell signalling pathways and virus infection 7096 10333 7097 114609 7099 3661 3665 7706 PMC8096351__F8 Identification, Biological Activities and Biosynthetic Pathway of Dendrobium Alkaloids 1690 3652 4598 4597 PMC8102494__F1 Conserved apoptotic pathways 581 637 7124 355 8772 PMC8103031__F2 CBP-JMF: An Improved Joint Matrix Tri-Factorization Method for Characterizing Complex Biological Processes of Diseases 3169 2065 10451 2064 2261 5881 7410 3725 771 4602 7031 607 4832 595 2353 29984 8607 4171 5437 5111 2305 7316 4099 968 1058 PMC8103423__F4 Cell biology of Parkinson’s disease 120892 948 2534 114548 3553 5340 3596 3902 65018 PMC8103580__F3 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy 7099 7186 7188 7124 8717 23118 257397 11035 197259 1540 8772 3146 90865 PMC8103580__F4 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy 596 8408 9776 9706 22863 55626 9474 10533 83734 9140 64422 2522 PMC8105091__F9 Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway 7099 4615 2729 2730 PMC8107692__F6 Resistin-Like Molecule A Dysregulates Cardiac Bioenergetics in Neonatal Rat Cardiomyocytes 7019 116447 11232 5442 34 35 5166 5163 5465 1374 1375 PMC8108589__F1 Proinflammatory pathways regulated by LRP-1: The interaction between LRP-1 and ApoE represses the formation of IRAK1–TRAF6 complex and therefore the NFKB-mediated pathway 348 4035 7099 4615 3654 3661 7189 3603 6347 PMC8110204__F2 Sirtuin-1 in Immune Response and Systemic Lupus Erythematosus 3578 23411 2475 3091 3558 4513 3146 4615 6774 50943 9774 3606 PMC8112168__F1 Multiple catalytic functions of IPMK in inositol biosynthesis pathway 253430 5728 9807 9677 PMC8113030__F3 Redox regulation of the insulin signalling pathway 208 5728 5163 PMC8113030__F4 Redox regulation of the insulin signalling pathway 2932 208 5163 PMC8114223__F1 Implications of the germline variants of DNA damage response genes detected by cancer precision medicine for radiological risk communication and cancer therapy decisions 2189 57697 2188 2178 2176 55215 2177 5889 7517 672 79728 675 5888 83990 5890 5892 7516 10111 4361 472 3014 PMC8114846__F2 Review of Recent Research on the Role of MicroRNAs in Renal Cancer 5728 407009 22943 27122 4089 6737 2539 7248 11035 2475 7189 3845 7422 PMC8116282__F3 Challenges in Paragangliomas and Pheochromocytomas: from Histology to Molecular Immunohistochemistry 2271 6392 6389 54949 6390 6391 8402 3417 2806 3420 4191 3418 112398 7428 PMC8117458__F7 Neuropathies and neurological dysfunction induced by coronaviruses 1636 581 59272 627 PMC8118237__F1 Intracellular and intercellular iron trafficking in the tumor microenvironment 3458 23657 960 3569 55640 150696 PMC8118521__F3 Transcriptional Profiling of Porcine HCC Xenografts Provides Insights Into Tumor Cell Microenvironment Signaling 4087 4088 4089 59 7124 1490 6347 4322 1027 2475 PMC8120202__F5 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS 1786 23476 7015 25780 50943 5728 4087 4088 4089 4091 4092 50507 4666 4040 4041 3146 1499 100126309 7253 PMC8122392__F2 Context-Dependent Impact of Integrin-Associated CD151 and Other Tetraspanins on Cancer Development and Progression: A Class of Versatile Mediators of Cellular Function and Signaling, Tumorigenesis and Metastasis 4040 4041 324 1499 999 3732 595 5970 977 4609 4602 948 PMC8122951__F2 Bone Marrow Niche in B-Cell Acute Lymphoblastic Leukemia: The Role of Microenvironment from Pre-Leukemia to Overt Leukemia 9242 6387 7412 4855 4854 652 7852 4597 9332 6376 729230 1524 5806 6347 PMC8123211__F3 PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions 142 3383 6347 10038 6348 6714 6387 PMC8123408__F2 Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis 7166 999 1000 PMC8124199__F3 JAK/STAT Molecular Pathway in Vascular Remodeling Associated with Pulmonary Hypertension 7431 4318 1003 PMC8124914__F2 Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy 7408 387 6010 PMC8125037__F2 PI3K/mTOR Pathway Is Targeted by Rare Germline Variants in Patients with Both Melanoma and Renal Cell Carcinoma 5728 2778 4157 4286 29072 55193 8314 6774 207 2475 3091 54617 4798 7248 7249 PMC8125972__F1 Impact of Epigenetic Modifications in Myeloid Malignancies 4893 2322 3845 3717 2624 4869 7157 2145 2146 23512 1788 171023 3417 54790 3418 PMC8125975__F3 Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility 4763 3265 673 3845 5894 6654 2885 5781 8036 PMC8126031__F3 Lessons to Learn for Adequate Targeted Therapy Development in Metastatic Colorectal Cancer Patients 9839 6935 3667 2475 3480 8205 79923 6774 PMC8126512__F2 Intersection of COVID-19 and cancer: signaling pathways and treatment implications 7514 6774 9118 695 3570 PMC8126620__F1 Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy 7535 920 2534 952 8205 3932 100187761 2885 27040 7409 PMC8126717__F2 Escape From Treatment; the Different Faces of Leukemic Stem Cells and Therapy Resistance in Acute Myeloid Leukemia 596 2167 4170 23476 4609 948 960 83939 3562 468 581 7852 6387 2305 7412 3383 9242 PMC8127529__F2 Azithromycin: Immunomodulatory and antiviral properties for SARS-CoV-2 infection 59272 7113 6868 PMC8130321__F5 Signature RNAS and related regulatory roles in type 1 diabetes mellitus based on competing endogenous RNA regulatory network analysis 7534 103106903 2057 79837 2520 5822 1431 2149 914 2069 5874 122961 100506776 92249 100506046 5305 3631 868 5527 PMC8131586__F6 Illustration of the positive feedback loop between tamoxifen-resistant ER-positive breast cancer cells and M2-like TAMs 1956 1950 8205 6774 383 PMC8131923__F3 Adipose tissue plasticity and the pleiotropic roles of BMP signaling 652 5159 650 4015 1386 655 PMC8131923__F5 Adipose tissue plasticity and the pleiotropic roles of BMP signaling 6778 1386 652 PMC8134730__F7 Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice 627 5879 3984 2475 PMC8136122__F4 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) 4088 7939 1499 1958 7078 PMC8136122__F5 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) 4087 4088 1499 324 PMC8136122__F6 TGFB1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review) 64866 7124 183 1956 PMC8136133__F11 Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer 5136 50940 1431 5451 3000 2986 2977 5593 8654 27345 2979 9626 1432 2978 4882 4880 4842 27094 5148 55811 4881 111 4878 4544 4843 2778 2774 2696 PMC8137704__F4 Whole transcriptome RNA-seq reveals key regulatory factors involved in type 2 diabetes pathology in peripheral fat of Asian Indians 1017 4654 8626 1019 1432 1457 8841 5594 10891 207 5595 4780 3172 28996 2099 3170 7341 133522 8431 PMC8137978__F1 Ferroptosis in Acute Respiratory Distress Syndrome 2879 27165 6520 23657 PMC8138777__F1 Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease 1119 367 7113 PMC8139196__F2 Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients 29110 8408 27185 114548 23411 23410 51548 142 PMC8140999__F5 Translational control by eIF2A phosphorylation 4553 83939 1998 PMC8141029__F1 mTORC1 stimulates SAM synthesis 3630 4144 55364 7249 4397 4149 PMC8144308__F1 Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics 6095 406 9575 PMC8144525__F8 Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury 2056 5894 2885 PMC8145522__F2 Contributions of Ubiquitin and Ubiquitination to Flaviviral Antagonism of Type I IFN 115004 29110 3661 3665 1386 57506 7706 9958 8241 PMC8146072__F5 Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation 3845 5728 2539 7086 6120 PMC8148155__F1 Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice 84188 55711 10400 PMC8148341__F1 Microglial Exosomes in Neurodegenerative Disease 967 928 975 3916 10490 143187 PMC8149214__F5 Epidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation 2475 3717 7010 2149 PMC8150754__F2 Therapeutic Strategies for Metastatic Triple-Negative Breast Cancers: From Negative to Positive 940 1493 5728 3091 5163 2475 367 324 4609 PMC8150801__F1 Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy 1386 2002 1499 1956 100133941 2308 367 1000 999 545 1111 5874 PMC8151534__F7 Evidence of Cooperation between Hippo Pathway and RAS Mutation in Thyroid Carcinomas 4771 5058 83937 166824 4485 2932 9113 26524 4089 1499 324 28996 2689 374 3689 174 2246 3397 3398 85407 595 4609 6657 329 332 PMC8153134__F2 Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders 5741 120227 1593 1594 7421 1591 8074 PMC8155538__F2 Renal Ciliopathies: Sorting Out Therapeutic Approaches for Nephronophthisis 359 1080 284086 6469 23432 6608 2737 PMC8157630__F6 Identification of significant genes as prognostic markers and potential tumor suppressors in lung adenocarcinoma via bioinformatical analysis 27040 23440 6010 998 790 PMC8160963__F1 Identifying Novel Actionable Targets in Colon Cancer 324 1630 4089 3845 673 7157 7048 581 3482 PMC8161298__F1 TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis 79923 6657 7015 PMC8161298__F7 TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis 5763 4194 55384 10664 26524 442916 4193 PMC8163539__F4 Systematic Pharmacology Reveals the Antioxidative Stress and Anti-Inflammatory Mechanisms of Resveratrol Intervention in Myocardial Ischemia-Reperfusion Injury 5879 114609 4615 5132 4284 958 107984471 6886 PMC8164969__F2 Molecular pathways governing hepcidin regulation in the liver 8452 9817 6774 151176 650 654 164656 3077 7036 57817 148738 7015 PMC8165385__F1 Methylene Blue Application to Lessen Pain: Its Analgesic Effect and Mechanism 4151 23411 627 1356 PMC8166896__F1 Molecular mechanism of necroptosis 23118 7186 81858 7124 1540 9825 90268 8717 8772 81030 8737 11035 197259 142678 7098 8473 5495 6790 2932 11140 8205 PMC8168423__F9 Oral intake of Lactobacillus plantarum L‐14 extract alleviates TLR2‐ and AMPK‐mediated obesity‐associated disorders in high‐fat‐diet‐induced obese C57BL/6J mice 355 4615 7097 114609 2167 PMC8168458__F1 Crosstalk between metabolic pathways and the tissues in which they are implicated in aging regulation 3643 3667 8660 3479 5728 23411 23373 10135 PMC8173049__F7 Lactoferrin Retargets Human Adenoviruses to TLR4 to Induce an Abortive NLRP3-Associated Pyroptotic Response in Human Phagocytes 7099 114609 4615 114548 834 7124 3929 8737 11035 3553 79792 PMC8182305__F2 Aquaporins in insulin resistance and diabetes: More than channels! 282679 364 366 360 3630 4099 PMC8186080__F7 Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression 9140 9776 55054 2475 PMC8186314__F1 GLI1: A Therapeutic Target for Cancer 6469 6608 51684 2736 2735 3845 673 4088 PMC8186467__F2 Bidirectional Relationship Between Cancer Epigenetics and Metabolism 6520 23657 586 8289 8314 2146 54790 PMC8190037__F3 Analysis of the role of PurA in the pathogenesis of Alzheimer's disease based on RNA-seq and ChIP-seq 3416 6622 4023 348 7124 8772 23385 637 2932 572 317 836 840 842 100506742 PMC8190181__F1 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer 6938 4092 4087 4088 4089 857 4018 960 6714 6497 8651 3717 6774 8703 2191 2069 3482 90865 PMC8190181__F3 Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer 3082 6387 1956 5163 2475 5728 650 4838 4087 4088 7852 3481 6374 7412 960 6678 PMC8191213__F3 Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation 10285 5747 7447 29899 7157 23213 860 3918 PMC8192426__F1 Contraction in airway smooth muscle (ASM) 387 6010 6786 PMC8192769__F5 Schematic diagram of the effects of fadraciclib at 4 h 983 637 581 331 572 27429 56616 PMC8194077__F1 Therapeutic Targeting of Notch Signaling: From Cancer to Inflammatory Disorders 182 3714 28514 54567 PMC8194085__F3 Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine 790 673 3845 5728 1956 6774 1950 1723 5163 7372 PMC8195994__F7 Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition 355 3667 7124 8862 187 5159 PMC8196151__F3 Phosphoproteome analysis with equal loading TMT11 provides a comprehensive overview of cancer-relevant pathways 613 930 5879 2475 1956 6595 673 5728 5163 2064 8626 8452 369 7080 572 842 6256 4193 4780 2932 7157 1830 672 4609 1728 595 5934 PMC8196612__F3 Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation 9290 7442 2166 6395 139760 PMC8196994__F1 Altered Signal Transduction in the Immune Response to Influenza Virus and S. pneumoniae or S. aureus Co-Infections 715 720 717 718 727 729 2271 PMC8197496__F2a Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma 545 472 675 84126 641 580 4292 10111 4361 3458 466 PMC8197724__F1 P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases 8772 637 666 331 581 317 PMC8198409__F2 Diacylglycerol Kinase alpha in X Linked Lymphoproliferative Disease Type 1 2534 10125 1606 PMC8198588__F2 Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis 9514 51083 9350 9334 8869 26301 53947 84002 6489 29906 2583 6482 10317 6483 2523 27090 PMC8199574__F3 Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Do Not Know 7054 1621 367 PMC8199681__F1 Molecular Details of the Frataxin–Scaffold Interaction during Mitochondrial Fe–S Cluster Assembly 23479 2395 51218 22 7523 3313 PMC8200538__F3 Comparative Transcriptomics of IBD Patients Indicates Induction of Type 2 Immunity Irrespective of the Disease Ideotype 6352 63925 2729 5335 30009 8916 6348 9337 3702 2625 90865 384 1233 29803 6361 6367 9173 3726 4094 157 11018 6387 3937 7026 1803 PMC8200981__F1 Neutrophil Extracellular Traps in Tumor Metastasis: Pathological Functions and Clinical Applications 4353 4615 54106 3146 4318 7099 1075 3611 5879 PMC8201055__F2 microRNAs in the Regulation of Melanogenesis 4157 1499 2932 4286 2885 7306 PMC8201103__F7 Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines 7494 83939 11331 5245 468 581 PMC8204022__F4 MicroRNA-Based Network Provides Potential Predictive Signatures and Reveals the Crucial Role of PI3K/AKT Signaling for Hepatic Lineage Maturation 1870 1499 6657 6667 8726 6925 1051 4088 10919 7067 865 2002 2033 2034 2078 6495 652 2100 23411 2147 862 2313 9252 84913 2353 468 10413 5971 467 2305 2309 430 50943 208 405 1436 283377 1408 4908 5295 84068 9464 7078 10957 2180 51247 157567 57520 387921 6095 169200 10857 5144 65084 5728 22849 6546 1955 2624 2625 79977 3206 4602 4149 79727 688 9314 9682 8850 3217 3172 7157 4286 5970 6774 4613 7704 7291 7161 1050 207 5089 9971 4790 10765 3091 22954 2113 6886 389421 6615 648 861 4780 6426 54971 144455 6772 5715 8626 2099 1958 PMC8204080__F1 O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function 10724 8473 3667 5163 2932 PMC8205588__F1 Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria 2879 8031 55240 PMC8208232__F1 Cross-talk between lipid homeostasis and endoplasmic reticulum stress in neurodegeneration: insights for HIV-1 associated neurocognitive disorders (HAND) 22926 83939 5091 7038 PMC8209414__F2 Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis 2147 5209 3099 2539 3939 2806 2805 5625 875 440 55902 948 PMC8209426__F10 An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure 472 2305 4661 7465 PMC8209977__F1 Homologous recombination, cancer and the ‘RAD51 paradox’ 472 672 675 79728 5888 5892 7516 5889 7517 580 83990 11200 7157 5728 4763 999 6794 55364 207 PMC8212127__F2 Insulin-Like Growth Factor Pathway and the Thyroid 8471 3667 8660 5266 2885 PMC8212127__F3 Insulin-Like Growth Factor Pathway and the Thyroid 8471 3667 8660 4193 PMC8212145__F4 Causal interactions from proteomic profiles: Molecular data meet pathway knowledge 5578 5580 2033 5241 545 6885 4683 672 5551 21 367 595 3169 27086 3315 200845 8204 9687 5366 23761 7031 5914 7494 472 8986 100133941 5591 9641 284217 3912 1230 834 4261 959 3458 3665 2475 6464 6714 6773 5371 30009 3595 3845 3932 5579 1001 2919 2296 5516 4602 5925 1026 1432 814 3619 4323 4318 56910 3880 22974 6934 2099 6197 6935 2671 1525 5743 1991 10043 5657 2113 2321 PMC8212145__F5 Causal interactions from proteomic profiles: Molecular data meet pathway knowledge 5241 2099 1291 367 596 4088 4089 5295 2309 5170 1027 3717 5579 1499 7249 2931 25937 5054 253260 2932 208 10000 207 2475 5970 5578 4904 6194 6195 572 673 5781 6464 6714 6774 4893 6198 2064 5595 1432 5599 5594 2065 5894 3084 3725 7529 2113 595 3932 5601 5562 31 32 2305 891 PMC8213587__F3 Rethinking the biology of metastatic melanoma: a holistic approach 4763 4893 673 4609 2475 3091 5728 3417 3418 PMC8215544__F4 Neddylation Regulates Macrophages and Implications for Cancer Therapy 581 81620 4998 7465 PMC8220142__F4 Dual Characters of GH-IGF1 Signaling Pathways in Radiotherapy and Post-radiotherapy Repair of Cancers 581 3717 2690 23650 472 3480 3479 PMC8222170__F7 KEGG pathology and disease analysis 3030 351 84890 1311 572 581 PMC8222483__F2 Linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target? 7049 4087 4088 4092 4089 4018 6010 6714 PMC8222712__F1 Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects 226 5066 2475 960 8205 383 6352 909 4609 PMC8226720__F1 An Overview on Diffuse Large B-Cell Lymphoma Models: Towards a Functional Genomics Approach 1840 2033 2146 939 970 613 6446 694 3394 958 7128 3569 604 595 54790 6761 8764 8085 PMC8227208__F4 p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies 1958 1050 1956 10569 367 6154 1728 4193 9683 83737 10413 4804 PMC8227515__F1 Emerging Role of Amino Acids of the Brain Microenvironment in the Process of Metastasis Formation 26227 6470 6472 PMC8228963__F8 Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NFKB Signaling Pathways Mediated by Gut Microbiota 7124 3553 355 PMC8229180__F2 AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells 8408 6009 2475 7054 1017 1019 PMC8229348__F2 Description of the relationship in healthy longevity and aging-related disease: from gene to protein 2309 2475 8074 9365 4609 9474 1581 7038 PMC8229352__F1 Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment 2475 9776 8408 10533 9140 9474 55062 11337 64422 100170220 PMC8229352__F5 Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment 960 3569 6774 1956 2475 1499 7471 4851 2309 6714 10413 PMC8231548__F3 Perivascular Adipose Tissue-Derived Adiponectin in Vascular Homeostasis 3667 8660 26060 3630 6247 PMC8232085__F4 Polyphenol Supplementation Reverses Age-Related Changes in Microglial Signaling Cascades 721 720 10054 10594 1642 220988 5243 317772 56252 1522 5690 1434 3458 713 3295 2495 7064 1509 2280 3635 51752 10312 2194 1499 1277 5720 3329 7001 1520 6648 6279 5721 3320 25939 3326 3073 3159 3689 871 6772 3684 2247 7184 3553 3309 231 5034 213 142 9601 7791 5223 92140 3308 5901 240 811 PMC8232321__F1 BMP Pathway in Blood Vessel and Lymphatic Vessel Biology 4090 4086 4091 4092 4089 4087 4088 PMC8232957__F1 Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy 948 3902 3579 4318 7494 1236 PMC8233288__F2 Moonlighting of mitotic regulators in cilium disassembly 7474 801 79866 4739 81565 5347 6790 54820 8321 1020 4085 701 699 8556 5108 3796 10013 3091 1856 4163 9184 11156 95681 27130 51343 991 11065 4750 324 55835 9738 4751 347240 7419 7272 PMC8233907__F9 Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness 4193 355 581 5728 595 983 1019 891 995 PMC8234298__F1 Spotlight on Accessory Proteins: RTK-RAS-MAPK Modulators as New Therapeutic Targets 10211 2319 27040 2549 9846 1796 9046 10818 8660 867 2885 1399 55914 2273 28964 2274 8826 8844 4691 8682 10636 8036 200734 161742 399473 10252 10253 PMC8234459__F3 Paradoxical Roles of Desmosomal Components in Head and Neck Cancer 1950 1823 1956 55914 1828 1829 857 595 1499 6591 4316 1830 1824 5317 11187 25818 PMC8234554__F2 An Updated Understanding of the Role of YAP in Driving Oncogenic Responses 387 26524 9113 154810 51701 999 1499 5784 92359 4485 PMC8234554__F3 An Updated Understanding of the Role of YAP in Driving Oncogenic Responses 3099 5209 400500 2752 4609 558 5469 1025 374 387 9411 6347 1435 23566 3569 1440 1437 4513 6374 79767 PMC8234904__F2 Evidence-Based Chemotherapy for Oral Cancer: Focus on Drug Resistance Related to the Epithelial-Mesenchymal Transition 5163 5728 4087 4088 4089 4092 PMC8234989__F1 New Insights into the Clinical Implications of Yes-Associated Protein in Lung Cancer: Roles in Drug Resistance, Tumor Immunity, Autophagy, and Organoid Development 4485 60485 9113 10664 558 7431 4609 983 595 6010 PMC8235637__F3 Molecular and Functional Analysis of Sunitinib-Resistance Induction in Human Renal Cell Carcinoma Cells 3916 3920 3815 2322 5979 2475 1902 387 9170 23566 2846 1499 999 51564 948 PMC8235708__F1 Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications 3603 3458 169355 23475 130013 PMC8236385__F1 Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses 4615 51135 4118 3654 7189 10454 23118 257397 51284 3929 7098 PMC8237272__F6 LGR5 enhances the osteoblastic differentiation of MC3T3-E1 cells through the Wnt/Beta-catenin pathway 1499 324 8549 860 PMC8240219__F9 Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway 9817 4094 197259 PMC8242269__F10 Large-scale Proteomic and Phosphoproteomic Analyses of Maize Seedling Leaves During De-etiolation 7808 5091 2597 6120 PMC8243427__F2 MicroRNAs: emerging driver of cancer perineural invasion 29102 54487 5901 27161 5073 PMC8245853__F2 CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment 4283 3627 6387 6469 1435 3133 3135 8205 355 942 941 6772 4513 10013 3902 1116 10630 7852 7422 3065 PMC8247027__F1 Pathogenic postzygotic mosaicism in the tyrosine receptor kinase pathway: potential unidentified human disease hidden away in a few cells 2885 3265 3845 2475 PMC8247090__F4 Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway 8643 8231 596 7054 22944 2717 PMC8247594__F2 Evolution of Our Understanding of XIAP Deficiency 10454 8915 8767 PMC8249349__F1 Metabolic alterations in pancreatic cancers 6120 22934 3099 3098 2806 2744 4190 4118 4199 11113 PMC8250149__F2 NLRC5: A Potential Target for Central Nervous System Disorders 84166 466 4049 7189 7187 1540 7706 PMC8251939__SF4 Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors 91653 3719 1630 847 PMC8253276__F6 Upregulation of Nogo‐B by hypoxia inducible factor‐1 and activator protein‐1 in hepatocellular carcinoma 998 6714 100196919 PMC8255536__F4 Proposed mechanism on cartilage repair and chondroprotective effects of IGF1-induced SMMSC-CM therapy 3479 6662 650 8817 3596 4322 9507 PMC8255928__F5 Integrative Analysis of lncRNA-mRNA Profile Reveals Potential Predictors for SAPHO Syndrome 8578 10206 1318 79157 728888 100132247 4154 9584 201895 3297 8602 338699 4016 92609 9943 84859 642799 9043 2204 10474 6482 23086 30817 23243 84942 100131017 64393 22806 2207 390927 55701 160364 23092 57475 2643 37 4082 8930 367 54512 PMC8257068__F1 Prospect of CDK4/6 Inhibitors in Triple-Negative Breast Cancer 5163 6009 5728 9191 7249 1021 1019 1017 1786 PMC8258105__F1 Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease 7113 59272 3569 7124 6850 54106 3627 6348 6351 64170 6347 3586 2219 PMC8258236__F2 Possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review 1386 3480 2002 1956 1588 7015 3479 6667 PMC8259581__F1 Corrigendum: Signaling Pathways Regulating Thermogenesis 1386 84872 4899 7019 7350 PMC8261594__F6 Study on the mechanism of the Modified Ginseng-Schisandra Decoction (MGSD) in the treatment of recurrent respiratory tract infection (RRTI) based on network pharmacology 7124 100187907 4117 8195 836 PMC8267408__F1 Chemistry-Assisted Proteomic Profiling of O-GlcNAcylation 5238 55577 8473 10724 2582 2585 PMC8267809__F1 Activated PI3Kinase Delta Syndrome—A Multifaceted Disease 3570 3566 930 958 613 5728 3575 5163 940 PMC8268239__F1 Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications 3397 3398 125061 8564 8942 130013 PMC8268497__F2 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development 2735 51684 2737 5727 2736 6469 6608 PMC8268497__F6 Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development 57534 102 3516 PMC8268913__F6 Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia 4771 4485 9113 2736 1499 PMC8269128__F3 Hypoxia and Hypoxia-Inducible Factor Signaling in Muscular Dystrophies: Cause and Consequences 5081 4617 4656 PMC8269357__F6 Identification of RNA-Binding Proteins Functionally Associated with Tumor Progression in Gastrointestinal Cancer 22926 581 9451 983 847 43 7054 6188 4609 10664 100187761 10291 6774 2103 55696 PMC8270011__F2 Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins 717 105031671 718 3383 7412 727 729 PMC8273387__F2 Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes 8737 1540 90268 8717 8772 7186 197259 11035 PMC8275668__F6 Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis 713 3273 714 567 653509 811 377 23647 378 6441 629 3098 7295 5199 173 4586 51727 1000 PMC8276988__F2 Immunogenic Cell Death: A Step Ahead of Autophagy in Cancer Therapy 55054 9140 9474 6845 84971 100170220 581 24145 PMC8277109__F2 Nutrient signaling pathways altered by methionine restriction (MR) 1998 468 26291 7350 27232 3479 PMC8277214__F1 Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study 2531 253782 29956 204219 10715 79603 91012 1674 PMC8277837__F5 Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma 4297 8085 25799 147929 10224 8427 117608 55422 3399 9869 4092 162972 284307 199692 7587 84775 92283 1490 284390 148266 10794 80110 79818 463 9314 4086 6934 7846 10383 2033 4088 4090 4087 23417 84617 3643 84790 117178 10376 4035 32 7100 23516 4306 23657 51129 PMC8278085__F7 PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin‐II by reducing TGF‐B1/Smads pathway activation 4087 4088 1896 4921 PMC8278114__F6 Pro‐inflammatory signals induce 20A‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal 7189 4615 7099 3725 2353 828 PMC8280132__F3 System biology approach based on metabolic biomarkers and protein–protein interactions for identifying pathways underlying schizophrenia and bipolar disorder 18 2571 2746 2747 56954 8659 2752 2744 1373 2673 9945 5471 PMC8282538__F6a Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells 1201 9374 53 410 3107 3134 2968 51172 1497 2634 2071 8884 27304 60490 4599 2356 80347 10243 79717 9014 6515 23057 9054 PMC8283198__F2 Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis 255738 3949 3383 7412 PMC8283590__F1 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update 2932 324 4041 4040 999 PMC8283590__F3 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update 8945 4485 26524 9113 1499 6925 4771 154796 182 PMC8286837__F1 Hypoxia activated UPR and DDR pathways 22926 83939 7494 468 472 545 2475 PMC8297548__F2 TIRAP in the Mechanism of Inflammation 8651 3654 114609 7099 7189 695 3656 4615 3146 7097 51135 7096 10333 PMC8297977__F6 Transcription Factors and Methylation Drive Prognostic miRNA Dysregulation in Hepatocellular Carcinoma 6714 10533 2305 5924 4323 5063 22808 2308 6446 983 572 1869 7852 1879 23462 5993 1576 38 4886 PMC8298820__F2 Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19 3146 59272 920 PMC8299209__F1 Pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway 324 1499 367 PMC8299464__F2 Stress Hormones: Emerging Targets in Gynecological Cancers 627 4803 6868 PMC8301038__F2 Redox Regulation of Lipid Mobilization in Adipose Tissues 50507 3630 4099 PMC8301472__F2 Molecular Mechanisms of Resistance to Immune Checkpoint Inhibitors in Melanoma Treatment: An Update 4318 4513 383 920 6367 941 1499 56477 942 1233 2826 8205 PMC8302405__F6 Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatigue 1674 9365 4937 8205 2241 6667 355 4118 9241 7054 PMC8303227__F1 Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target 6741 7515 5423 11284 2237 3978 7150 545 472 580 672 79728 675 5893 146956 80198 51750 84464 641 10721 571 7518 3981 200558 286257 7486 1643 7508 2067 5426 5424 4437 4436 4292 5395 2956 9156 PMC8303227__F4 Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target 672 9156 5888 10111 5810 4361 5893 675 79728 55920 9656 472 580 545 2956 83990 983 1017 1356 11073 6741 PMC8303459__F1 MEK5/ERK5 Pathway in Health and Disease 4047 9314 10365 9564 5058 PMC8303459__F3 MEK5/ERK5 Pathway in Health and Disease 998 5058 10365 9314 9242 PMC8304794__F5 Transcriptomic Profiling of Femoral Veins in Deep Vein Thrombosis in a Porcine Model 7124 4049 11171 10763 351 759 PMC8305053__F1 Mutations in TSC Genes on Neurodevelopment and Synaptic Transmission 3667 5163 7248 6009 2475 5728 7249 7124 253260 PMC8306262__F4 Statins: a repurposed drug to fight cancer 3652 2879 2643 PMC8306267__F2 Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria 2147 5340 718 727 PMC8311559__F1 Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases 940 2475 6774 324 3553 50943 PMC8313886__F2 N6-methyladenosine methyltransferases: functions, regulation, and clinical potential 4609 27125 4175 4174 81559 29102 595 1499 2475 79618 200734 5728 23035 7799 7528 4193 64065 57721 2309 6657 9589 PMC8315560__F1 Cancer stem cells, epithelial-mesenchymal transition, ATP and their roles in drug resistance in cancer 8205 2735 1499 2875 PMC8321552__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) for the nucleotide excision repair pathway 7508 1069 7507 1869 4609 472 545 4171 2521 5728 64065 637 4193 6477 64326 836 2475 6741 9156 5395 4436 2956 4292 4437 27030 5111 4171 4089 1017 5111 1022 8317 699 4661 9184 9126 PMC8321592__F1 Cancer Genomic Profiling in Colorectal Cancer: Current Challenges in Subtyping Colorectal Cancers Based on Somatic and Germline Variants 324 1499 8312 673 4292 5426 5424 7157 54894 6662 5290 5093 PMC8324391__F1 Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy 8452 9817 7942 9706 10533 2308 23411 22863 PMC8325099__F7 Identification of novel biomarkers for arthrofibrosis after total knee arthroplasty in animal models and clinical patients 6010 7046 7048 4087 4088 4089 PMC8326529__F9 Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis 613 930 5728 951 7249 6009 5934 4602 PMC8327843__F2 Regulatory T cell infiltration in tumors: implications for innovative immune precision therapies 6361 6367 1233 1237 1234 2826 6346 6352 56477 2833 PMC8328045__F5 Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron 3553 7124 947 9619 619511 7099 466 PMC8328766__F3 Astrocytes: a double-edged sword in neurodegenerative diseases 1644 7018 6010 6774 9021 5163 2475 PMC8329526__F2 Context-Dependent Roles of Claudins in Tumorigenesis 80763 5728 3280 6880 79923 861 4609 2932 999 324 607 4072 4087 4088 7297 PMC8331109__F8 Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways 3725 5595 7157 836 3558 7124 1950 5294 1956 356 2247 3791 7422 3643 7045 3815 2353 5970 1019 PMC8334851__F2 Impacts of Immunometabolism on Male Reproduction 50943 920 7124 958 941 942 PMC8335696__F5 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway 7124 1956 3717 1432 4312 2324 3312 2597 5604 6401 5594 5602 2152 5595 5159 4314 2147 2950 PMC8335742__F9 Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway 9817 114548 3606 79792 PMC8339209__F2 Recent Progresses in the Treatment of Osteoporosis 1499 4040 4041 2932 324 3725 6667 860 4920 PMC8345080__F1 Osteopontin as a Regulator of Colorectal Cancer Progression and Its Clinical Applications 5727 650 10873 56955 1758 1834 659 7046 4086 2113 7048 4089 7421 4088 860 324 51176 2932 1499 6925 PMC8347825__F2 Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment 7508 2067 672 7515 5395 4436 4292 PMC8348825__F1 Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta 2885 3952 3717 3667 3553 2002 9882 3630 3480 PMC8348889__F1 SARS-CoV-2 and Acute Cerebrovascular Events: An Overview 59272 5340 7450 7018 7035 PMC8349405__F3 Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens 4953 6723 6611 54498 6303 196743 1984 83475 1725 PMC8349779__F1 Reprogramming of glucose transport and glucose metabolism in renal cancer 5091 2539 2146 6774 5163 7086 PMC8349779__F2 Reprogramming of TCA cycle, fatty acid and glutamine metabolism in renal cancer 10514 140805 95 2271 3033 18 4015 4513 355 4018 2744 4609 6510 PMC8350166__F1 PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective 5728 940 2475 324 6774 PMC8350386__F1 MicroRNAs in Transforming Growth Factor-Beta Signaling Pathway Associated With Fibrosis Involving Different Systems of the Human Body 3717 9618 4087 7046 25805 4092 7189 4089 4091 PMC8350729__F2 Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications 3091 6774 2475 6608 2735 596 142 581 595 3725 PMC8350904__EV4 Schematic depiction of the metabolic networks active during latent HIV‐1 infection in microglial cells 6389 2271 25796 2203 22934 3098 2645 2539 9563 47 4190 5226 7086 5105 5236 2821 5230 226 2597 441531 2023 5313 160287 PMC8352204__F3a Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors 152485 58491 56853 51077 405 1535 90550 7095 2021 4602 375519 284254 9516 84246 7053 55075 7051 26256 4292 5378 PMC8353216__F2 COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes 7113 1636 59272 PMC8353884__F7 Proposed Model of IKK:NFKB:Notch Signaling Control by SLX4IP and RAP1 128710 84464 8554 3516 7015 23493 3280 PMC8354730__F2 Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders 718 2932 7099 361 1431 7124 348 PMC8359344__F3 Multifaceted role of cell cycle regulators in the coordination of growth and metabolism 1019 55669 5898 10628 1020 983 1017 1021 999 324 201163 PMC8359344__F2 Multifaceted role of cell cycle regulators in the coordination of growth and metabolism 1869 51548 79071 8660 355 2744 1719 PMC8359440__F5 Enantiomer‐specific pharmacokinetics of D,L‐3‐hydroxybutyrate: Implications for the treatment of multiple acyl‐CoA dehydrogenase deficiency 3158 3155 65985 47 PMC8361327__F2 Functional and Clinical Characteristics of Cell Adhesion Molecule CADM1 in Cancer 23705 7291 4282 999 PMC8362800__F2 SPOP and CUL3 Modulate the Sonic Hedgehog Signal Response Through Controlled Degradation of GLI Family Transcription Factors 51684 6608 2736 5727 8405 2735 6469 PMC8363310__F3 Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections 960 60485 9113 26524 4485 5728 51421 253260 2475 64223 5879 6446 1499 4609 PMC8363758__F6 Schematic illustrating RhoA-actin-serum response factor (SRF) signalling pathway 6722 387 5187 8864 9572 PMC8366499__F1 Genetic and Physiological Effects of Insulin on Human Urate Homeostasis 126669 2885 10257 9429 PMC8369417__F6 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases 4067 930 695 7006 100124696 4772 29760 4615 PMC8369429__F2 Peptides that immunoactivate the tumor microenvironment 5464 201633 151888 3902 941 942 PMC8372643__F3 HIF1Alpha-PFKFB3 Pathway in Diabetic Retinopathy 5209 2147 324 999 PMC8375320__F1 Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development 9780 2324 60485 4485 9113 25937 10413 26524 63895 PMC8375320__F3 Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development 10413 59341 25937 652 8100 1003 2064 3796 9780 PMC8379496__AF1 Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation 595 891 983 1019 5106 PMC8381213__F1 Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense 6773 10379 7297 3661 9636 PMC8385664__F2 microRNAs, the Link Between Dengue Virus and the Host Genome 51284 4615 3661 2932 PMC8385858__F8 Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer 969 1019 595 999 4313 596 PMC8386020__F4 Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers 64423 6009 1956 7939 PMC8387624__F4 Functions of Hepatitis B Virus Encoding Proteins: Viral Persistence and Liver Pathogenesis 7419 4318 4313 1958 22809 2475 6667 574473 6774 8974 2146 22882 27250 1499 2308 PMC8388841__F1 Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability 5888 472 6935 PMC8389562__F4 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer 8420 57291 105372978 389421 100500882 101805488 8405 4609 440894 8939 10644 4282 148756 100129662 2146 PMC8390275__F5 Sirtuin3 rs28365927 functional variant confers to the high risk of non-alcoholic fatty liver disease in Chinese Han population 664 23410 6648 PMC8391121__F1 Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases 6714 1956 1950 4690 7410 5881 PMC8391142__F2 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers 7042 3553 10397 PMC8391142__F3 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers 6774 23476 80312 10752 6657 1984 2475 PMC8393314__F1 Glycosylation in Melanoma Progression 2651 2524 2523 6487 2526 2530 9245 6480 2147 7038 7054 5340 558 1956 999 8869 10610 4162 51083 PMC8393567__F2 GSK3 as a Regulator of Cytoskeleton Architecture: Consequences for Health and Disease 4131 2932 7476 PMC8393694__F2 Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates 153830 3156 39 338 PMC8393865__F3 Concurrent BMP Signaling Maintenance and TGFB Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear 11059 64750 9958 9618 7267 1540 54778 51132 83737 7375 8239 4092 4088 4087 8237 7189 868 55611 51592 23327 64219 55223 11060 10273 84676 6885 10987 7128 11274 4734 4086 4091 4093 4089 84085 PMC8394324__F3 Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer 7124 355 8772 637 4170 100188864 581 331 317 PMC8395114__F6 Clavibacter michiganensis Downregulates Photosynthesis and Modifies Monolignols Metabolism Revealing a Crosstalk with Tomato Immune Responses 5598 1243 6187 PMC8397082__F1 Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects 55636 6899 9464 2304 5308 4089 23399 7050 2296 2303 657 PMC8397419__F8 Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Improve Ovarian Function and Proliferation of Premature Ovarian Insufficiency by Regulating the Hippo Signaling Pathway 9242 4485 9113 26524 PMC8398289__F3 Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells 5873 7786 1499 490 4286 1638 PMC8403639__F1 NRF2 signaling pathway 8452 9817 4094 1728 2729 2730 PMC8405566__F3 Candidate model for Ccr4-Not mediated nutrient signaling 1233 54700 11201 375 PMC8405630__F4 Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy 545 994 993 995 983 1017 472 6908 54700 4193 1021 1019 PMC8407594__F1 Combined overview of all qualitative Wnt (sub-)models found within the 19 Wnt simulation studies 1950 8313 1956 4040 1848 2932 324 28514 22943 84667 3955 85407 64321 PMC8408559__F5 Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer 415116 2520 3939 3566 7248 9113 7295 6367 4869 10628 22800 7428 5159 23221 3949 64857 2176 6794 6382 6351 3845 2313 1191 7011 6774 5292 440514 8312 2114 5076 672 3952 5450 2261 861 2246 3481 64764 5340 613 596 5156 4193 23263 5077 858 2122 2626 5079 867 2624 26524 2115 2078 11315 1001 5080 6886 10215 8522 5075 5971 6452 6670 4094 942 6347 PMC8410789__F8 Working model of Alpha-KG-induced pyroptosis 4190 841 56169 PMC8411019__F2 Specialized Proresolving Mediators for Therapeutic Interventions Targeting Metabolic and Inflammatory Disorders 59352 6095 2358 2854 2861 PMC8414998__F2 Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance 3569 7124 3458 3558 3663 6772 7039 6774 3662 196 6778 3565 3596 3586 1435 PMC8415231__F2 Targeting the Wnt/Beta-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis 4094 1499 6422 11197 324 22943 PMC8415548__F5 Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy 81539 6510 2744 2936 23657 6520 2937 2879 7295 4025 100188812 3652 7037 7018 2194 3162 4057 2181 5447 2495 2512 23479 9054 493856 48 PMC8416054__F3 Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease 26191 7189 7185 958 960 50943 355 941 940 PMC8423577__F3 Remodeling of Macrophages in White Adipose Tissue under the Conditions of Obesity as well as Lipolysis 9573 8877 4513 9021 6774 PMC8427239__F3 MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine 8829 7422 7528 999 23429 PMC8427323__F1 Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells 4118 1537 55364 PMC8429596__F1 Translational Potential of RNA Derived From Extracellular Vesicles in Multiple Myeloma 2191 9242 100169750 5684 2919 8190 161497 PMC8430316__F2 Molecular mechanisms contributing to the formation of cancer-associated adipocytes 6774 9021 5140 4609 4320 PMC8430477__F2 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 7422 7412 23411 468 22926 9817 581 PMC8430873__F3 Cyclin Dependent Kinase-1 (CDK-1) Inhibition as a Novel Therapeutic Strategy against Pancreatic Ductal Adenocarcinoma (PDAC) 983 572 581 PMC8431328__F1 Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder 196 405 1543 1545 1544 PMC8436916__F9 DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis 4314 4318 1789 8989 4513 176 PMC8440421__F5 Chitosan-mediated cGAS-STING and inflammasome activation, and the promotion of Th1 responses 115004 29110 3661 3458 114548 3553 PMC8443980__F1 Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases 65018 114548 7350 10533 9140 9474 PMC8446275__F1 Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing 5888 672 5066 3981 PMC8446557__F3 EGFR‐mutated stage IV non‐small cell lung cancer: What is the role of radiotherapy combined with TKI? 472 5111 5888 672 2932 7518 1499 4361 10111 2065 2064 7515 PMC8450413__F2 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer 6259 387 3725 23002 1386 998 PMC8450413__F3 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer 324 4040 4041 7048 7046 4087 4088 4092 999 2932 2735 2736 6608 6422 27123 PMC8450413__F5 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer 64840 1499 324 PMC8450894__F2 Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ 8213 7099 929 PMC8451771__F3 Apoptosis – Fueling the oncogenic fire 2021 6774 115004 5879 998 PMC8452151__F2 Molecular mechanisms for combinatorial encoding to achieve stimulus-specific responses 114609 7099 4615 8717 3661 7097 7098 57506 2002 PMC8454549__F3 Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse 64220 3875 1282 1284 1581 2492 7226 1382 5308 1536 6469 PMC8455272__F8 TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease 4843 383 4360 1437 58191 6366 6363 PMC8456215__F8 Emerging Targets in Type 2 Diabetes and Diabetic Complications 10507 6714 1003 4851 4854 3091 693164 PMC8456215__F1 Emerging Targets in Type 2 Diabetes and Diabetic Complications 7248 5163 7249 2932 PMC8456397__F2 Molecular Insights into the Crosstalk Between Immune Inflammation Nexus and SARS-CoV-2 Virus 7098 3661 7297 3717 10379 6773 PMC8458751__F7 Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis 3988 7808 581 5447 11113 PMC8458764__F2 Metabolic Contributions of Wnt Signaling: More Than Controlling Flight 1499 324 2932 PMC8460909__F7 Myeloid-Derived Suppressor Cells Alleviate Renal Fibrosis Progression via Regulation of CCL5-CCR5 Axis 6352 1234 4087 4088 PMC8461092__F2 Interaction Between PEDV and Its Hosts: A Closer Look at the ORF3 Accessory Protein 83939 7124 51028 PMC8461142__F1 Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD+-dependent metabolic adaptation 23411 952 10135 203447 23410 PMC8464874__F6 L-Plastin Phosphorylation: Possible Regulation by a TNFR1 Signaling Cascade in Osteoclasts 6714 7189 6010 4023 PMC8465902__F5 Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer 9927 7018 2242 PMC8466094__F2 Crosstalk between Autophagy and Inflammatory Processes in Cancer 4615 2475 345611 1386 22926 8878 PMC8466180__F2 Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future 4193 6774 23657 6520 1723 3156 2937 2879 3652 2932 7301 PMC8467449__F3 Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer 5174 255738 3949 6721 3156 6646 19 1586 PMC8468334__F2 Type I Interferons in COVID-19 Pathogenesis 59272 57506 10010 3660 10379 6773 PMC8469180__F3 Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Glucose Homeostasis and Diabetes-Related Endothelial Cell Dysfunction 2885 3667 5163 PMC8469789__F3 Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes 5111 2177 355 5289 2322 PMC8469825__F1 Autophagy Dysregulation in Diabetic Kidney Disease: From Pathophysiology to Pharmacological Interventions 2475 81671 8408 9140 9474 55014 PMC8471002__F1 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models 324 1499 4091 4089 4087 4088 4092 PMC8471002__F2 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models 387 3611 6722 10454 3553 7099 4615 7189 51135 PMC8471547__F6 SMAD4 Feedback Activates the Canonical TGFB Family Signaling Pathways 91 7018 659 7048 4089 1385 6667 PMC8472426__F6 HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells 22926 1998 83939 7494 468 3315 PMC8472822__F1 Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases 1356 55240 875 100188776 8031 3652 2879 100 10162 2182 PMC8475945__F3 Unfolded Protein Response Pathway in PC3 (A) and ARCaP(M) (B) cells 22937 468 821 596 7186 7494 22926 56605 267 7415 10808 811 10682 10956 6671 PMC8480058__F2 Macrophages and cancer stem cells: a malevolent alliance 941 10384 2043 961 960 6657 6714 8205 PMC8481821__F2 Neu Perspectives, Therapies, and Challenges for Metastatic HER2-Positive Breast Cancer 572 2885 2475 3091 7039 1950 3084 1839 PMC8482240__F7 Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level 3073 11240 5660 59272 5476 1359 7064 57486 4311 1215 1511 1522 1519 2169 1368 1636 1363 5547 90701 1113 10752 34 3158 549 2760 8635 4125 PMC8485071__F6 Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review 6850 2886 5900 1981 3845 PMC8486193__F4 Reactive oxygen species in cancer: Current findings and future directions 355 8772 637 2475 581 317 PMC8490010__F3 From APC to the genetics of hereditary and familial colon cancer syndromes 4436 4292 324 657 658 90 54894 84133 5111 5395 27030 92 93 4913 8549 4968 6794 4595 1499 PMC8495134__F1 Epilepsy in the mTORopathies: opportunities for precision medicine 92335 5163 7249 7248 51256 5728 6009 2475 9681 8131 10641 PMC8497523__F7 Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways 4830 4832 55276 11164 3615 5198 10606 51727 272 132 8622 5144 PMC8497618__F8 Proposed model of how Enpp4/S1pr5 controls pronephros patterning 22875 7849 53637 54361 PMC8497755__F1 Metabolic Modifications, Inflammation, and Cancer Immunotherapy 51304 10331 1499 1950 1956 PMC8497895__F1 Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer 545 472 6741 7465 983 84126 672 5888 PMC8498116__F1 Targeting the Integrated Stress Response in Cancer Therapy 1998 468 83939 PMC8502815__F7 Beta-Carotene in Colonic Inflammation and Intestinal Barrier Integrity 7099 3553 7124 1401 929 PMC8503266__F1 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects 998 5058 960 PMC8503815__F2 Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer 1603 836 572 842 468 5728 581 5163 PMC8504100__F3 Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives 1493 3569 6774 6347 729230 7852 2191 PMC8504955__F3 Large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain 5213 5214 5211 230 2023 2026 4539 5236 4714 4726 91942 56901 4694 7360 178 4190 4191 48 50 1355 9377 1346 28958 65260 2572 3420 6389 6390 6391 4967 1743 PMC8505360__AF1 Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis 2475 6647 8408 22863 PMC8505641__F4 Mechanisms involved in the modulation of inflammation by miRNA derived EVs 5728 6714 114548 6774 3654 51135 4615 920 27250 PMC8505796__F5 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer 648 216 22933 1017 898 4751 PMC8508814__F1 Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy 768 6774 7018 PMC8509131__F1 NLRP3 Inflammasome: Relevance in Solid Organ Transplantation 114548 140609 10628 6850 8772 3146 7124 3661 PMC8509806__F6 Anti-Hepatocellular Carcinoma Biomolecules: Molecular Targets Insights 5728 581 1019 PMC8510449__F7 Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review 7465 891 995 PMC8512456__F2 Tumor immune microenvironment in epidermal growth factor receptor-mutated non-small cell lung cancer before and after epidermal growth factor receptor tyrosine kinase inhibitor treatment: a narrative review 50943 2920 1956 2919 558 3611 1493 7852 6372 10663 6774 5728 3480 4088 64320 4087 100313837 6696 PMC8514750__F5 GTPase-Dependent Mitochondrial Dynamins in Heart Diseases 23410 4976 115209 PMC8516342__F8 Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3B 51441 2932 759 51527 1537 847 PMC8517487__F10 Expression of Microtubule-Associated Proteins in Relation to Prognosis and Efficacy of Immunotherapy in Non-Small Cell Lung Cancer 8863 8864 5728 7248 572 324 10682 1537 4179 1017 472 545 100188776 8638 PMC8520510__F4 Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma 79885 1676 6092 5313 57118 80243 6331 5292 1719 6624 958 8324 5315 4772 10765 3269 4437 2395 2072 65125 28964 940 865 6093 9839 9112 6868 93 664 2113 55388 5783 4893 7048 857 3667 6242 4085 688 23405 8493 3456 6399 54361 9314 387 5879 4193 1788 1977 3685 9585 6657 9774 8741 346389 5925 29843 79923 214 3569 2099 8660 93649 5829 2534 2034 7042 3084 84950 331 1027 1019 7422 595 1000 648 182 8829 6418 4088 29127 6662 57522 1839 960 3688 4609 5782 3690 672 596 6117 2078 3206 3066 3480 4087 3091 6711 8091 1021 3680 6667 8317 7525 3586 4171 649 673 4363 1500 3611 149233 10298 6659 2239 6608 83660 9978 1871 481 30837 79003 84823 382 6453 8835 2071 961 4739 5530 121340 1080 1656 2314 3696 4811 120 92140 1105 6239 PMC8520510__F6 Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma 2932 4999 6502 4087 4088 4089 4171 1537 1017 5111 1022 8318 10926 993 699 9184 9126 10274 10735 PMC8521155__F1 The Complement System by Neoplastic Disease of the Central Nervous System 717 718 4179 1604 727 966 PMC8521937__F4 Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy 4738 9978 7353 8452 9817 4094 PMC8525330__F3 CREB1 coordinates transcriptional networks in DCs and CD4+ T cells which drive key immune effector functions 8764 79004 961 255231 387 3845 7975 759 10392 1026 808 5698 8907 162 1211 6892 4345 4217 6909 6095 2323 3606 677 5532 207 7292 4050 602 940 51284 7305 11009 3627 919 9261 3135 1535 10456 4850 920 5778 22849 5300 54014 5606 3663 26137 4282 1385 2000 58480 1387 7323 64710 8320 29110 1147 29979 5641 5908 6886 8458 2185 5371 26060 3170 2002 1236 5468 9070 81704 81493 1523 6693 27020 23309 1874 PMC8526972__F1 Inter-Kingdom Signaling of Stress Hormones: Sensing, Transport and Modulation of Bacterial Physiology 7054 1621 5409 PMC8526999__F3 Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells 1021 1019 1017 1537 324 57695 999 983 PMC8529048__F2 Anti-flavivirus Properties of Lipid-Lowering Drugs 1717 4597 3156 355 PMC8529555__F6 Network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease 7490 7421 5226 688 468 8841 1649 3172 6721 6720 7528 4802 4199 2645 229 230 5313 5162 51621 50814 6307 7108 1595 2222 2224 4598 10682 3156 65985 4047 6713 4597 3422 1718 1717 6309 39 3949 29881 57678 80339 53345 1581 51144 79071 9415 3992 6319 2194 31 47 55902 1385 PMC8531217__F6 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development 7108 50814 51478 1595 10682 4047 6309 1717 6713 10858 1718 PMC8531643__F1 Aberrant Metabolism as Inductor of Epigenetic Changes in Breast Cancer: Therapeutic Opportunities 1786 1788 65094 2475 6839 999 2194 PMC8532171__F6 Flg22- and D-glucose-biased signaling 1178 10211 578 PMC8533869__F1 TGFB Signaling in the Pancreatic Tumor Microenvironment 4089 7048 7046 4087 4088 PMC8533960__F3 Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer 613 930 3667 5879 5728 9241 5624 572 6009 672 5934 84188 4602 51083 PMC8534156__F3 Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers 2885 6714 2549 1445 PMC8534197__F8 Molecular Signature Expands the Landscape of Driver Negative Thyroid Cancers 3458 5649 7148 8324 4040 6520 1439 3454 3455 2322 1956 2064 2690 9180 5728 2885 201163 83667 729438 3667 6774 6773 6775 6778 2932 7249 7248 51256 11186 1499 324 6009 842 4193 595 4609 64798 9675 64223 329 5292 11040 25776 PMC8534645__F2 Sirtuins as Interesting Players in the Course of HIV Infection and Comorbidities 51548 23411 23410 2308 5465 2194 PMC8537160__F1 Wnt and Beta-Catenin Signaling in the Bone Metastasis of Prostate Cancer 4920 4040 4041 324 1499 998 387 PMC8537916__F2 Mitochondrial Contributions to Hematopoietic Stem Cell Aging 23410 2475 7454 6648 51547 100187761 114548 3553 PMC8541208__F5 Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis 355 8772 637 4170 8717 7186 7124 581 PMC8541410__F2 An Update on Innate Immune Responses during SARS-CoV-2 Infection 114548 57506 3661 7187 29110 7098 7189 51284 7097 7099 4615 51135 3665 3454 3455 3716 6772 7297 6773 10379 PMC8542577__F4 Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease 51491 7056 7008 8061 60675 1051 1281 9611 2494 862 5629 PMC8546664__F1 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy 4255 27301 4595 8930 4350 3980 5427 55247 143 10039 252969 10038 5426 5111 57804 10714 11284 27343 5423 6996 7374 4436 2956 27030 5425 4437 5983 6118 5982 6117 5395 5984 23648 6119 29935 1643 1022 902 8451 1069 2965 2966 2967 2071 2074 2068 2072 404672 728340 2968 730394 5431 54107 56655 5886 7508 7507 545 580 641 472 672 675 4683 144715 84464 7486 7516 5591 7518 4361 27434 1791 10111 2547 PMC8547806__F2 Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGFB/Wnt/Beta-Catenin Pathways and PPARG 1950 324 1499 4151 PMC8550885__F2 Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan 6009 7124 7248 7249 5163 253260 PMC8552907__F4 Enrichment analysis for specific cellular pathways 23225 11097 8086 161 9688 9818 23165 1173 160 1175 10552 53371 830 10094 10109 3326 58533 6643 10961 1211 9631 2923 163 5867 11311 5878 3482 7037 10525 10294 1650 23193 998 253725 9897 51726 5589 6184 1213 7841 6745 6185 821 2332 9470 1973 8666 6238 9101 140886 26999 9765 1968 1965 55768 3309 10273 27248 64744 80267 7327 9532 6048 7184 201595 7919 5976 8027 4116 10482 10921 10254 84364 26286 7879 9775 10189 22985 10015 10484 9135 10890 80223 3107 3998 10483 29927 22872 11021 9984 79228 80145 3105 57187 84321 PMC8555029__F4 Cellular mechanosignaling in pulmonary arterial hypertension 59341 6426 162514 4854 PMC8555221__F2 Systematic review of proteomic biomarkers in oral squamous cell cancer 595 1019 1021 PMC8555666__F10 Differential Association of Free, Conjugated, and Bound Forms of Polyamines and Transcript Abundance of Their Biosynthetic and Catabolic Genes During Drought/Salinity Stress in Tomato (Solanum lycopersicum L.) Leaves 5183 384 50964 PMC8556195__F1 Plasticity of pancreatic cancer stem cells: implications in therapeutic resistance 6608 51684 79923 6657 960 1499 4040 4041 2932 324 3714 182 4609 PMC8560908__F1 The interplay between NFKB signaling and ARTD family members 54625 64761 142 84875 57506 29110 5971 PMC8560908__F5 The interplay between AKT signaling and ARTD family members 2932 10038 10039 142 23239 23411 5163 7248 2308 PMC8563889__F1 Ferroptosis, radiotherapy, and combination therapeutic strategies 4193 5465 10162 472 6319 2643 5447 1719 23657 3652 468 PMC8565650__F4 Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways 3667 5728 6009 5163 7249 7248 PMC8566438__F1 Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years 9049 196 6714 405 57491 PMC8566527__F6 The mechanism of CIRT boosts anti-tumour immune responses in melanoma-bearing mice 3717 6774 383 PMC8568331__F2 Targeting cyclin-dependent kinase 4/6 as a therapeutic approach for mucosal melanoma 1956 4763 5922 3815 3265 4893 673 4296 595 5925 5728 1499 PMC8568515__F1 MANF: A Novel Endoplasmic Reticulum Stress Response Protein—The Role in Neurological and Metabolic Disorders 83939 1998 468 7494 7873 PMC8570012__F1 Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance 6352 9242 6355 3577 3090 1950 2919 6774 3627 PMC8570568__F3 An ageing innate immune system may predispose a patient to severe COVID-19 59272 114548 5132 3569 7124 3603 3627 6347 PMC8571357__F7 PER2 mediates CREB-dependent light induction of the clock gene Per1 8864 23373 5187 PMC8573113__F2 TDP-43 and ER Stress in Neurodegeneration: Friends or Foes? 7494 83939 468 22926 PMC8573346__F8 Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway 4513 114548 79792 3603 PMC8576424__F2 GIP Receptor in the CNS for the Pathogenesis of Obesity 2695 2696 9021 PMC8579446__F3 Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer 283120 326343 378938 5820 2182 10162 55240 7018 55384 283131 145249 4015 23657 6520 2879 401253 652995 100129387 60674 PMC8579452__F3 IL-1B in atherosclerotic vascular calcification: From bench to bedside 5879 5880 114548 3949 3553 4040 4041 PMC8579729__F1 Complement in ischaemia–reperfusion injury and transplantation 5648 10747 718 727 1431 PMC8580479__F1 Hallmark features of cellular senescence 100653366 6347 6364 2475 PMC8580835__F2 Host cell-intrinsic innate immune recognition of SARS-CoV-2 3836 3661 57506 29110 9636 8651 6772 6773 4928 8480 PMC8582018__F1 Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies 2182 10162 5447 3652 23657 6520 2879 3315 55240 10533 9474 8031 9817 3658 PMC8582018__F2 Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies 23657 2879 4015 7157 239 PMC8582580__F3 New Look of EBV LMP1 Signaling Landscape 1499 3662 3665 8994 406947 2633 8717 7186 55072 3718 7188 3091 23118 3654 PMC8584052__F2 P5C as an Interface of Proline Interconvertible Amino Acids and Its Role in Regulation of Cell Survival and Apoptosis 4609 29920 5831 5625 PMC8584317__F4 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis 6469 650 860 3549 581 2736 2735 6608 PMC8584434__F4 Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications 59272 1636 718 7018 727 7035 PMC8586713__F1 PTSD as an Endothelial Disease: Insights From COVID-19 5045 5340 59272 6046 23476 PMC8589187__F1 Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing 5617 3479 435 4942 100653366 262 6723 6608 PMC8591138__F6 Identification of Cross-Pathway Connections via Protein-Protein Interactions Linked to Altered States of Metabolic Enzymes in Cervical Cancer 79003 253260 6790 1031 9184 2932 991 5163 2316 4194 598 29110 1019 990 4172 2475 890 637 7098 7186 23118 7157 7124 5187 51343 2280 26052 4353 8896 5329 4678 2521 5928 3308 7448 5054 1387 4841 5984 283571 822 8078 5983 11315 4282 84817 9406 51747 7298 PMC8591178__F1 Inborn errors of IL-6 family cytokine responses 3590 27040 1178 367 1271 3977 3976 5008 9180 PMC8592893__F4 Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer 114609 4615 2475 3716 3717 2932 PMC8593216__F6 APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells 5111 545 2669 PMC8593325__F3 Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease 627 65018 55486 PMC8597313__F2 New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis 836 5585 10133 9217 65018 11075 4747 4744 9118 115004 4537 4541 PMC8600818__F9 Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1A/miR-210/Rad52 pathway 3014 472 5893 PMC8601278__F3 Bioinformatics analyses of the pathogenesis and new biomarkers of chronic obstructive pulmonary disease 959 962 22914 3702 1236 921 3820 1669 27040 2625 671 3575 915 926 5004 3240 2882 2841 4050 51227 122618 9466 114804 3945 286530 399 322 2323 10225 10219 84992 596 58473 26999 53347 54205 6932 4609 54850 64919 3250 51312 57447 6095 114792 10920 6304 9804 2395 4300 6942 55670 29883 2762 23404 10469 8607 26520 2962 6908 6638 10713 6880 51611 80145 54984 25904 6118 6191 10492 57194 9184 924 4927 933 65008 4353 6228 7535 10557 3932 4063 917 83732 6233 923 51176 274 PMC8602198__F1 Contribution of miRNAs in the Pathogenesis of Breast Cancer 6714 6774 6772 2021 5728 5163 572 1616 8772 842 637 693152 581 331 8717 836 6093 PMC8603984__F6 cGAS/STING: novel perspectives of the classic pathway 65018 581 29110 115004 90550 10133 2475 3661 197259 PMC8605121__F1 Dysfunction of miR‐802 in tumors 85407 6416 1499 768219 6934 999 1000 619501 51715 864 5091 6925 6935 2305 5901 10776 7534 2319 2638 25925 8683 689 254048 2475 1540 5728 29116 118856 3310 390 PMC8607308__F2 Infection with SARS-CoV-2 shows differential gene expression in Interleukin-6 signaling 9021 867 6774 5781 3717 3572 7297 3570 6772 3716 3569 PMC8607389__F1 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease 9475 387 5728 842 572 4193 596 5163 2475 595 PMC8607389__F5 G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloidB in Alzheimer’s disease 387 2932 5091 6010 4018 6722 23621 PMC8610101__F1 Complement Pathways 720 721 717 718 727 735 PMC8614664__F2 Animal Models of Coenzyme Q Deficiency: Mechanistic and Translational Learnings 51117 93058 51805 55486 57017 10229 79934 23590 57107 51004 27235 PMC8615041__F1 IL-36A and Lipopolysaccharide Cooperatively Induce Autophagy by Triggering Pro-Autophagic Biased Signaling 27179 4615 2353 3725 929 7099 114609 51135 3656 3654 4703 6774 9776 2475 9140 9474 64422 PMC8615223__F4 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights 2932 5728 2475 572 596 4193 PMC8615411__SF1 Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues 1591 120227 1593 PMC8615588__F1 Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs 1950 1956 2064 2065 7039 10718 3084 145957 9542 387 11319 2885 2066 PMC8615680__F1 Genetic Determinants of Plasma Low-Density Lipoprotein Cholesterol Levels: Monogenicity, Polygenicity, and “Missing” Heritability 29881 64240 64241 8647 6580 79660 2646 1581 6272 4043 4036 4035 51128 4547 4023 348 3949 3156 255738 10577 4864 29116 10487 3990 27329 51141 6927 26119 3988 1071 19 3931 4018 114881 PMC8616391__F2 Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It 55240 2512 8031 6520 2937 2879 23657 3162 4495 2182 10162 PMC8616505__F2 Interplay between the Unfolded Protein Response, Inflammation and Infection in Cystic Fibrosis 22926 7494 7186 4781 1998 468 PMC8617980__F1 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? 100 84890 132 952 4860 PMC8617980__F3 Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose? 368 695 339983 3383 PMC8619803__F1 Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair 4361 1763 9156 3417 641 5371 80198 57697 246243 142 50485 84083 6596 5111 5981 7515 23030 5893 546 2177 1616 84464 7156 PMC8620733__F8 CDK4 in the Pathogenesis of Pancreatic Cancer 2932 6502 4999 23594 4176 4089 1017 923 4193 5111 1022 8317 10926 993 11076 9184 9126 10274 10735 929 PMC8620733__F9 CDK4 in the Pathogenesis of Pancreatic Cancer 342979 3716 6774 572 842 675 1019 5888 51426 PMC8621356__F2 Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach 572 5163 7249 7248 2475 5728 2308 PMC8621356__F3 Targeting PI3K/Akt/mTOR Pathway by Different Flavonoids: A Cancer Chemopreventive Approach 3667 6009 5728 5164 2475 7249 7248 1977 5163 PMC8622815__F1 AHR Ligands in Skin Homeostasis and Cutaneous Inflammation 196 405 9049 7018 6714 57491 5053 PMC8623831__F4 Treatment of HT29 Human Colorectal Cancer Cell Line with Nanocarrier-Encapsulated Camptothecin Reveals Histone Modifier Genes in the Wnt Signaling Pathway as Important Molecular Cues for Colon Cancer Targeting 5066 27346 6093 6382 2288 29072 27125 9736 8239 4316 4001 4089 1736 9765 23112 4088 1019 595 6249 6233 324 2237 4646 4172 4904 6885 6422 6144 84231 7750 9169 4254 10370 PMC8624704__F5 Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response 5727 6469 135 2033 238 2919 2247 5048 5764 3084 PMC8626541__F1 FA-BRCA Pathway 91442 57697 79728 80233 5888 675 29089 2177 55215 84464 2072 80198 51455 PMC8627624__F1 Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation 5728 5266 4067 PMC8631470__F1 Cross-Talk Between Tumor Cells Undergoing Epithelial to Mesenchymal Transition and Natural Killer Cells in Tumor Microenvironment in Colorectal Cancer 581 5111 5817 6868 3146 201633 56253 4277 100507436 23705 999 PMC8633576__F13 Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3B Pathway and Activating Autophagy in Gastric Cancer 995 983 2932 142 581 PMC8634426__F1 From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin 10111 4361 3014 472 10276 387 PMC8636777__F4 Weighted Gene Co-Expression Network Analysis and Treatment Strategies of Tumor Recurrence-Associated Hub Genes in Lung Adenocarcinoma 11149 1080 998 717 64398 7408 11346 5896 1740 100187761 283078 6010 5872 5966 2626 PMC8637192__F6 Copper Tolerance Mechanism of the Novel Marine Multi-Stress Tolerant Yeast Meyerozyma guilliermondii GXDK6 as Revealed by Integrated Omics Analysis 847 2729 2937 4351 11113 2821 PMC8637646__F2 Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle 2475 57103 5728 367 4609 3417 4899 8205 3418 81539 8140 PMC8639577__F2 The PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions 29851 942 941 2475 940 5728 6502 4088 7409 7535 5335 324 PMC8641543__F2 Inhibitors of glucose metabolism 3939 3945 3099 3098 26227 2875 PMC8641784__F3 SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease 59343 26168 29843 4208 5371 26054 6047 6613 6612 PMC8642070__F4 Bicuspid Aortic Valve: Genetic and Clinical Insights 6597 3720 23385 PMC8642467__F4 Mutations that switch genes from two-hit to one-hit drivers in six cancer types 7157 5290 4763 9817 5728 6794 5163 472 4893 4089 673 4087 4088 546 4851 7249 2475 4193 PMC8643130__F2 Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies 114548 4088 3606 3553 4803 PMC8645889__F7 Hif-1A/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker (Larimichthys crocea) under environmental hypoxia 581 637 3297 PMC8646547__F2 Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID‐19 disease progression 7098 7099 51284 51311 4615 6651 57506 29110 3661 3665 3716 7297 6773 6772 10379 3659 8651 9021 PMC8650509__F4 Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease 50507 79400 27035 10811 124056 90527 53905 50508 405753 50506 PMC8651476__F2 Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases 51284 7096 7097 3661 3665 7098 7100 7099 27177 27179 56300 PMC8652208__F3 Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation 50964 4280 207 8074 PMC8652378__F1 Oxalate synthesis pathway and molecular mechanisms leading to primary hyperoxaluria 112817 9380 183 PMC8656574__F2 Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application 3037 594842 2309 1000 960 105371152 920 2146 2662 PMC8656811__F3 Genome Instability in Multiple Myeloma: Facts and Factors 5079 1879 2308 60468 3492 3662 613 50802 3535 5896 5897 3146 7494 604 PMC8657039__F2 Early TP53 Alterations Shape Gastric and Esophageal Cancer Development 472 545 7465 PMC8657427__F2 Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches 960 6774 572 PMC8657471__F2 EREG/EGFR Pathway in Tumor Progression 6714 1956 2069 5874 374 2475 6774 3717 3099 5163 PMC8657471__F3 EREG/EGFR Pathway in Tumor Progression 374 2069 1956 1950 3082 PMC8660125__F1 Regulation and Function of Interferon-Lambda (IFNλ) and Its Receptor in Asthma 222256 3661 51311 7098 51284 3659 3383 3665 7189 PMC8662355__F2 Roles of Gasdermin D in Coronavirus Infection and Evasion 114548 79792 174 PMC8664259__F7 Role of TAF7 in linking transcription and translation 1283 23476 6879 6872 10763 7008 PMC8664591__F1 Appetite Regulation of TLR4-Induced Inflammatory Signaling 4852 4160 5443 23237 1392 7200 PMC8665869__F5 Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling 6774 114548 3553 9447 PMC8665957__F1 Review: the effect of light on the key pigment compounds of photosensitive etiolated tea plant 1371 5498 5447 7389 7390 210 PMC8666369__F8 IPA on CCl4-induced liver fibrosis 4092 4087 4088 3603 PMC8667691__F1 Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer 29102 54487 27161 51163 5901 PMC8667978__F1 Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects 7018 7099 1431 5132 51284 54106 PMC8669610__F3 TGFB Signaling and Resistance to Cancer Therapy 8916 4092 64750 4087 4088 4089 693137 389856 3146 9429 PMC8669610__F4 TGFB Signaling and Resistance to Cancer Therapy 6347 8205 50943 6352 PMC8670088__F1 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis 650669 10230 55000 5820 8847 154860 5315 7503 64002 100132735 3939 7248 7249 6009 100124700 541471 PMC8670088__F2 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis 3458 283120 283131 8110 3939 3553 5315 3586 3569 PMC8670943__F1 Chinese Herbal Medicine Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating Endoplasmic Reticulum Stress 1101 83939 468 PMC8674945__F1 Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation 5340 3183 718 1401 6714 7448 4035 PMC8677397__F5 Sishen Pill Maintained Colonic Mucosal Barrier Integrity to Treat Ulcerative Colitis via Rho/ROCK Signaling Pathway 5728 1003 4851 6010 7454 3553 PMC8677728__F1 Targeting PI3K/Akt signal transduction for cancer therapy 1956 10818 2885 2549 613 7189 5163 5728 545 472 29110 7249 7248 3479 3480 PMC8678153__F4 Synthetic lethality of ATM and ATR 472 545 7465 995 PMC8683078__F2 Biofactoid data is connected to information sources and establishes a bridge between related pathways 759 3725 6613 23410 7341 3550 6612 29843 7350 23408 4208 23373 55902 3418 9572 1386 6648 2746 23269 5053 5371 7157 1026 3065 983 PMC8684084__F4 Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma cancer 2264 7097 3492 6850 930 3688 2885 5879 5747 3667 2791 6654 5290 146850 5728 3265 5170 11140 200186 6794 10000 23035 4515 54541 7248 7249 4846 5578 29941 6009 2932 10971 2309 572 6256 3164 1147 4193 64223 2475 57521 2997 598 596 4790 7157 672 5105 4609 595 1017 1027 5934 356 4170 4602 1977 6194 PMC8687743__F2 HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer 3297 10013 79969 7415 PMC8689194__F3 Endotoxin causes inflammation and leaky gut through activation of NFKB pathways 7189 4615 929 3929 PMC8692584__F1 E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe? 10487 10486 23118 257397 10454 10155 7124 8737 5970 1540 138065 8239 4055 7186 5971 331 8767 64127 10392 5966 10346 10600 25893 7097 4615 3663 7099 3661 6737 PMC8692627__F6 Representative mechanisms of tsRNAs in malignancies 861 3714 4904 27161 26524 3091 6885 51460 7976 4691 23405 PMC8693501__F8 Extracellular HMGB1 interacts with RAGE and promotes chemoresistance in acute leukemia cells 596 2475 9776 60673 PMC8694403__F3 iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis 7099 1356 7018 6520 5621 6774 5163 55240 2638 2937 7428 1957 10533 9474 2879 8031 2056 7037 226 10162 2182 1537 100 PMC8696218__F7 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 1956 3480 2064 2475 6657 4609 PMC8698353__F5 Effect Mechanism of Electroacupuncture at ST36 on the Injured Extensor Digitorum Longus in the Jumping Rat Model Based on mRNA-Seq Analysis 8027 1154 4609 351 1029 836 581 596 PMC8698706__F10 Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid 4999 5000 6502 4171 4172 4173 4087 4088 4089 1017 1869 5111 1022 8318 8317 993 699 4661 9184 9126 10274 10735 991 PMC8698755__F5 Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer 8651 8835 9021 3716 122809 9655 30837 3717 6772 3718 6773 5292 6774 596 11040 7297 6775 6776 6777 6778 415116 4609 3265 369 5604 5595 3845 673 5594 5605 5894 3479 5291 5290 5289 5294 5293 5288 5286 5287 5295 5296 23533 30849 5163 207 2475 57521 55615 208 64798 64223 8503 146850 5728 10000 84335 253260 79109 PMC8698915__F4 Antibody and Protein Profiles in Glaucoma: Screening of Biomarkers and Identification of Signaling Pathways 715 716 718 727 710 3146 5648 717 735 729 PMC8699740__F2 Integrin AE(CD103)B7 in Epithelial Cancer 969 7046 5335 3682 864 3611 999 6348 PMC8699756__F3 Transcriptome Analysis in Vulvar Squamous Cell Cancer 1874 4609 4171 4172 7029 1869 10278 8318 7157 6693 472 494551 699 7529 7533 7531 51343 10393 29882 51434 11140 8697 991 25847 996 51529 PMC8699891__F5 Molecular Basis of Accelerated Aging with Immune Dysfunction-Mediated Inflammation (Inflamm-Aging) in Patients with Systemic Sclerosis 7518 7808 581 PMC8703169__F1 Mitophagy in Diabetic Kidney Disease 23304 197131 23352 55486 7415 PMC8703169__F3 Mitophagy in Diabetic Kidney Disease 3164 4485 23410 6502 51199 7942 664 PMC8704600__F1 Crosstalk between Statins and Cancer Prevention and Therapy: An Update 6010 1956 596 581 PMC8712723__F1 Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus 3665 4615 54106 3661 29110 115004 3550 6772 3716 3454 7297 6773 10379 5371 3669 2056 PMC87143__F6 E2F gene regulatory pathway 1019 1869 1870 1871 5111 5888 990 4998 4173 4176 4172 4171 4174 4175 1017 991 699 890 10926 PMC8714803__F7 Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic 4294 3725 65057 2872 116986 2194 156 7054 23379 10188 81857 9905 23513 84678 5566 4363 7249 489 57130 PMC8716783__F2 Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in Oncology Via Regulating Oncogenic Signaling Pathways 283120 1499 2475 324 8772 PMC8716846__F6 Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury 613 930 6850 2885 5728 5163 951 7249 572 6009 4193 51083 672 4609 5934 150365 4602 PMC8722763__F6 Ailanthone suppresses the activity of human colorectal cancer cells through the STAT3 signaling pathway 581 6774 983 999 1000 PMC8727744__F1 Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy 383 3620 6347 1019 PMC8727744__F3 Targeting Myeloid-Derived Suppressor Cells to Enhance the Antitumor Efficacy of Immune Checkpoint Blockade Therapy 383 3458 6774 3620 3569 1437 4739 PMC8728518__F2 PLK1 inhibition-based combination therapies for cancer management 5347 2475 23476 6774 1956 6714 7874 51185 PMC8730820__F2 Multiple MuSK signaling pathways and the aging neuromuscular junction 4038 285489 4593 1499 4090 4086 2147 790 4089 PMC8733402__F1 Longevity Factor FOXO3: A Key Regulator in Aging-Related Vascular Diseases 2475 3479 2309 3630 3643 5728 PMC8733955__F2 Metabolism of invading and circulating (detached) cancer cells 2168 2167 2171 10645 6657 27165 5091 3939 6659 440 1374 6714 7424 117581 2194 79966 55902 134526 89780 4087 6678 PMC8733955__F3 Metabolism of cancer cells colonizing in distant organs 5625 2194 5091 2167 2171 23235 6714 6472 55248 123706532 948 26227 PMC8739678__F3 FcG receptors in HER2-targeted breast cancer therapy 11277 790 637 27429 PMC8740020__F3 Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design 22926 83939 8651 9021 PMC8740421__F7 Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation 7099 27161 8829 PMC8742449__F5 Induction and application of ferroptosis in cancer therapy 3460 6772 3458 3716 3717 3459 23657 6520 2879 6774 5873 177 3586 383 9474 7040 PMC8745001__F4 Cytosolic Quality Control of Mitochondrial Protein Precursors—The Early Stages of the Organelle Biogenesis 115209 3297 83939 22809 468 197131 PMC8745310__F1 Ubiquitin Signaling in Innate Immune Response by Herpesviruses 8168 9958 7706 135644 79845 220213 6737 11074 3661 29110 57506 23650 83737 201292 54941 PMC8745434__F1 Hedgehog Signaling Pathway in Idiopathic Pulmonary Fibrosis: Resurrection Time 5727 891 2737 6608 51684 374654 2736 55733 57758 84976 64399 2619 387 5879 PMC8745478__F2 P38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer 581 1386 26959 2624 994 PMC8745764__F4 COVID-19: Immunohistochemical Analysis of TGFB Signaling Pathways in Pulmonary Fibrosis 207 4088 4087 59272 PMC8748693__F3 Metabolic routes contributing to ferroptosis 55240 6510 23657 94081 6520 2879 3652 1723 2182 PMC8748997__F8 The proposed model 3454 7297 3455 8651 2475 383 PMC8750274__F2 Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer 9474 1017 1020 983 8408 7942 9776 22863 201163 7249 1019 1021 664 11337 7405 79065 9140 81631 PMC8750350__F3 Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities 2203 3146 9518 2919 6347 968 PMC8750610__F1 Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials 7415 6774 9531 PMC8757397__F1 Pathophysiology of COVID-19-associated coagulopathy 59272 3569 3553 6347 7124 1401 5340 7018 7035 PMC8758495__F3 Amyloidogenic vs non-amyloidogenic pathway 8754 351 23621 PMC8759737__F1 SHP2-associated Noonan syndrome in RASopathy 1443 2549 2885 PMC8761945__F3 Emerging Role of Rho Guanine Nucleotide Exchange Factors in Cardiovascular Disorders: Insights Into Atherosclerosis: A Mini Review 6010 9138 8874 9732 23263 9639 8997 85440 998 PMC8765545__F7 Exploring Long Non-Coding RNAs Associated with IP3/DAG Signaling Pathway as Potential Biomarkers Involved in Mast Cell Degranulation in Chronic Spontaneous Urticaria with 2-Year Follow-Up 998 842 572 4513 PMC8770601__F1 Major metabolic pathways leading to the formation of signaling molecules from PUFA-GPL and pGPL 4015 4513 4353 4221 PMC8771831__F3 Melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease 8660 3667 2932 PMC8771833__F4 Slit/Robo Signaling pathway in Bone Metabolism 6091 64221 6586 6092 9353 PMC8771834__F3 Insight of Autophagy in Spontaneous Miscarriage 1486 7942 285973 10533 5228 6469 7422 6387 PMC8772974__F3 Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease 115004 7099 7351 PMC8773035__F1 Exosomal microRNA Differential Expression in Plasma of Young Adults with Chronic Mild Traumatic Brain Injury and Healthy Control 3207 6209 23305 2051 5728 100313781 60674 574461 7124 7422 22846 100859930 406932 PMC8773522__F1 Impact of Cancer Cachexia on Cardiac and Skeletal Muscle: Role of Exercise Training 7124 4087 4088 3479 2475 PMC8773878__F5 Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment 1956 920 941 958 940 PMC8774031__F7 Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications 27343 11201 6169 6181 2475 PMC8774043__F7 Extracellular HSP90A Induces MyD88-IRAK Complex-Associated IKKA/B−NFKB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization 51135 3654 7099 4615 7297 3717 3661 6774 7124 3586 9332 9554 PMC8774233__F2 Metastatic Progression of Osteosarcomas: A Review of Current Knowledge of Environmental versus Oncogenic Drivers 6010 182 3516 10232 6935 4316 7291 999 4513 6662 PMC8776955__F5 Calcineurin-dependent NFAT signaling as shared signaling pathway for IBD and SCZ 596 5534 4775 5579 5590 5599 572 5595 836 4772 5566 7534 808 7529 5581 2033 3164 7533 4773 5580 7532 7531 1457 4209 2810 1326 8021 5901 100187761 5530 5533 5532 2280 PMC8777512__F1 O-GlcNAcylation links oncogenic signals and cancer epigenetics 2673 9945 64841 5238 6675 8473 10724 PMC8777554__F2 Wnt/Beta-catenin signal transduction pathway in prostate cancer and associated drug resistance 25805 2932 1499 324 54894 PMC8777575__F2 Gold complex auranofin: new perspectives for cancer therapy 9429 83939 581 596 4170 2309 2475 PMC8780133__F3 N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy 23373 7225 627 2932 PMC8784274__F3 Transcriptomic Analysis Reveals a Link Between Hippo Signaling Pathway and Macrophages in Lungs of Mice with OVA-Induced Allergic Asthma 56288 7003 60 27113 7531 332 374 84962 653 2246 5054 6591 659 896 7042 154796 27040 92597 23513 3397 8463 23418 654 650 2932 10297 652 7004 8321 122786 286204 7483 26524 89780 324 7480 51176 81029 84612 23286 84552 7476 8313 54361 60485 8322 85407 11186 25937 5516 4609 6657 7855 8325 5584 85409 7482 5522 PMC8784382__F2 Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases 3716 6774 83939 468 7186 10392 64127 8767 7494 22926 PMC8787047__F3 Accentuating CircRNA-miRNA-Transcription Factors Axis: A Conundrum in Cancer Research 1021 1019 7391 4087 4088 4089 7528 999 1000 2309 581 406935 2475 406962 PMC8790411__F1 Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers 5426 4193 4283 80312 PMC8790852__F1 Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer 3082 1956 6714 1499 2885 5335 6774 2549 1398 2475 960 PMC8790913__F8 SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration 942 3108 3109 3113 3115 3122 7124 7305 2207 54209 3689 6351 6376 1436 84868 7018 PMC8795890__F3 Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration 1499 3486 9242 2475 4851 54567 3606 6662 378938 23314 22943 100302148 PMC8797823__F5 Frizzled receptor expression on patients’ survival with gastrointestinal cancers: A systematic review with meta-analysis 1445 324 5879 6010 PMC8798237__F3 Key genes involved in cell cycle arrest and DNA damage repair identified in anaplastic thyroid carcinoma using integrated bioinformatics analysis 4999 6502 1874 4118 1537 1017 4193 5111 1022 8318 10926 993 3240 699 983 4661 9184 PMC8798716__F9 Identifying the potential regulators of neutrophils recruitment in hepatocellular carcinoma using bioinformatics method 27040 4937 23440 6010 790 100 PMC8799543__F2 Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury 3579 4282 57007 960 972 367 114548 6647 6207 3553 PMC8800342__F1 Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress 4609 3725 572 PMC8802208__F1 DSB repair pathway choice 7486 11284 7518 142 7517 5893 5888 675 672 PMC8804296__F3 Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis 637 581 8772 PMC8808072__F9 Polygenic networks in peripheral leukocytes indicate patterns associated with HIV infection and context-dependent effects of cannabis use 1855 7423 5604 2932 5228 5295 7422 3082 87 572 1499 5599 3480 5155 3265 6714 673 3845 10000 5290 5605 5595 5579 8503 5291 5293 208 5601 26060 596 598 5594 1950 6197 637 5578 3725 5170 3678 5728 5159 6696 331 5900 PMC8809547__F2 EBV-driven 1C pathway drives nucleotide and glutathione synthesis 26227 29968 5723 4522 81034 94081 6472 10797 25902 PMC8811717__F4 Integrated Stress Response, Drug Targets, and Drugs 2932 57761 467 1998 26471 468 22926 7494 PMC8815749__F5 Bioenergetic Evolution Explains Prevalence of Low Nephron Number at Birth: Risk Factor for CKD 8408 7248 2475 1786 7428 PMC8816882__F2 Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target 2879 581 114548 79792 11035 8737 8772 197259 7124 PMC8817562__F1 Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy 57291 4553 2932 324 1499 100124700 6774 PMC8817869__F7 Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling 23411 2308 5105 PMC8819183__F3 Comparison of Tendon Development Versus Tendon Healing and Regeneration 642658 4087 4088 283078 1958 151449 8200 392255 1959 PMC8819497__F9 DDR‐dependent matrix‐mediated drug resistance (MMDR) to MAPK‐targeting therapies in melanoma 780 4921 5971 PMC8821531__F6 T Cell Repertoire Abnormality in Immunodeficiency Patients with DNA Repair and Methylation Defects 472 3630 8163 PMC8821659__F4 Comparative Study of Bacillus amyloliquefaciens X030 on the Intestinal Flora and Antibacterial Activity Against Aeromonas of Grass Carp 5164 11113 7808 18 5009 PMC8830521__F6 Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer 1499 6608 4613 4609 23035 4513 PMC8831562__F2 USPs and NFKB signalling 1540 9958 10869 7124 8717 7186 23118 257397 7189 PMC8832142__F1 Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis 5741 7428 3939 2744 4538 PMC8832959__F1 Cancer metabolism and dietary interventions 586 11113 55902 38 47 2805 4190 587 2806 4199 4118 3939 3795 3099 3098 PMC8833440__F1 Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway 1901 53637 9294 8877 56848 124976 1903 8698 PMC8833603__F4 Protein Disulfide Isomerase in Breast Cancer 22926 468 83939 PMC8834185__F2 Cytoskeletal Remodelling as an Achilles’ Heel for Therapy Resistance in Melanoma 5062 5058 6722 PMC8834247__F5 Put in a “Ca2+ll” to Acute Myeloid Leukemia 10538 3662 7535 940 3458 942 941 PMC8834311__F4 Endocrine Fibroblast Growth Factors in Relation to Stress Signaling 83939 468 26291 8074 PMC8834883__F1 Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions 2475 64422 10533 9474 9140 9776 8408 9706 PMC8834883__F3 Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions 5728 10533 55054 2475 9474 100302116 9140 22863 PMC8834953__F3 Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives 3146 114548 3553 PMC8835409__F5 Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers 581 5728 668 51616 PMC8835793__F3 Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential 7097 3479 3480 5163 6009 64223 1499 367 PMC8836889__F1 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review 317 596 4170 581 472 4193 PMC8840702__F1 Ferroptosis in cancer therapy: a novel approach to reversing drug resistance 467 2936 2879 367 10112 3934 5447 4015 382 2182 10162 PMC8841732__F10 All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐KB Signaling Pathway 57506 7189 3553 PMC8841999__F1 ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets 25923 51368 7095 9236 55014 8673 1571 338 7353 6400 PMC8842666__F6 ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability 7189 127247 5970 PMC8844822__F1 SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites 10135 23057 23098 PMC8846306__F2 Running ‘LAPS’ Around nLD: Nuclear Lipid Droplet Form and Function 137964 84803 4018 10555 84649 PMC8846368__F2 Targeting Nutrient Dependency in Cancer Treatment 4609 5290 9817 8314 4397 4507 23657 PMC8847160__F1 Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy 2879 7018 8031 PMC8847686__F10 Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder 10454 7186 8717 1616 PMC8847901__F1 Autophagy and skin wound healing 664 2475 9776 60673 22863 9140 83734 9474 10533 2309 64422 PMC8848980__F3 Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus 7148 1278 85301 1438 4804 1101 3082 5649 2324 5293 1439 118788 5579 1129 917 10235 3683 10636 27040 653361 1080 1524 7454 10750 6401 7124 29760 4671 695 4050 650 25805 PMC8852737__F4 Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor 7042 331 142 683 650 2944 7046 6648 6790 4313 4318 5328 213 7298 5468 308 367 5241 3479 1017 836 2950 3320 3791 2260 3265 1956 6714 3643 1111 598 2099 5599 1495 890 5594 1432 4193 5604 5295 3815 3717 2263 3702 7421 208 3558 2066 5781 4835 5320 5914 2100 3718 5294 PMC8855225__F1 Gli Phosphorylation Code in Hedgehog Signal Transduction 1356 374654 51684 23432 156 6608 5105 25989 27148 PMC8858883__AF1 Puerarin specifically disrupts osteoclast activation via blocking integrinB3 Pyk2/Src/Cbl signaling pathway 3725 6714 100187907 PMC8859176__F10 Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation 2146 9682 627 PMC8859819__F4 Epigenetic regulation of inflammation by microRNAs in post‐infectious bronchiolitis obliterans 64806 8744 9180 3452 50616 939 847 604 3454 2057 3572 8660 3605 10018 9140 5293 1236 10344 23411 3667 6654 6369 6364 2322 1387 6347 6502 2309 3845 3815 10803 3576 2920 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1571 100653366 PMC8868482__F1 Involvement of Inflammasome Components in Kidney Disease 7494 22926 57506 10628 114548 PMC8868551__F8a Folic Acid Homeostasis and Its Pathways Related to Hepatic Oxidation in Adolescent Rats Exposed to Binge Drinking 27035 847 1571 1719 50507 PMC8869096__F1 Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer 64798 2475 64223 114548 100418973 3586 3606 PMC8869227__F4 Cytoplasmic and Nuclear Functions of cIAP1 958 7186 7187 4615 7099 10454 23118 257397 8717 998 PMC8870198__F1 SMAD4 Inactivation in Epithelial–Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link? 4087 4088 4089 4092 4091 7018 2475 998 387 PMC8870278__F3 Mitophagy in Viral Infection 7284 114548 57506 9474 PMC8870356__F1 Integrins in Modulating Smooth Muscle Cell Plasticity and Vascular Remodeling: From Expression to Therapeutic Implications 1956 1499 6714 2932 PMC8874090__F4 Long non‐coding RNAs in diabetic wound healing: Current research and clinical relevance 3481 2191 2200 5629 5728 6996 5351 1839 4149 54790 2146 6722 PMC8874499__F3 Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods 4513 5604 5894 5595 3767 5330 2784 51764 80834 3709 3782 3781 3780 5972 2697 57369 53373 219931 7417 7419 112476 5331 183 3606 2776 1636 8862 187 8989 7442 759 PMC8875868__F6 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance 2539 3242 83933 4248 999 PMC8879274__F1 Potential to Fight Obesity with Adipogenesis Modulating Compounds 5156 5159 4041 1499 1050 5468 6608 10891 7350 4023 6295 PMC8880046__F2 Adaptive Immune Responses, Immune Escape and Immune-Mediated Pathogenesis during HDV Infection 6774 969 952 PMC8880704__F9 Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus 948 10998 2167 6256 3157 335 336 345 10873 6319 1581 10062 1582 1593 4023 2180 1622 2168 2170 10999 4973 1962 30 6342 51 7350 116519 5360 3611 9415 123 51129 9370 10580 4312 7316 5105 1376 33 34 5170 364 PMC8886057__F2 ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids 1738 1892 1962 3030 594 56922 64087 549 34 64064 5019 39 587 593 36 35 18 3033 11112 26275 84693 30 3032 10449 5096 PMC8886606__F1 Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook 3553 3383 2833 355 PMC8889147__F3 Network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease 2744 6713 213 6579 5978 153 154 30 155 1544 5743 5465 3577 5468 5467 36 5538 100996569 5243 1621 1589 4967 2908 10682 5328 7173 43 2098 PMC8889569__F4 Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells 4018 1902 23566 57121 10161 2846 9170 2475 PMC8889620__F2 Involvement of LDL and ox-LDL in Cancer Development and Its Therapeutical Potential 6657 79923 3949 2475 10666 222256 6774 595 4318 PMC8889667__F2 Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia 894 4345 7097 7099 4582 7157 PMC8889909__F2 Physiological and Pathophysiological Roles of Metabolic Pathways for NET Formation and Other Neutrophil Functions 2539 6120 7086 PMC8891265__F1 Diet, lipids, and antitumor immunity 355 95 6576 47 6319 5763 PMC8893235__F2 Promising Therapeutic Candidate for Myocardial Ischemia/Reperfusion Injury: What Are the Possible Mechanisms and Roles of Phytochemicals? 3717 672 5662 1674 8408 9706 664 PMC8894239__F1 mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment 6009 7249 7248 64798 5728 5163 2309 PMC8894804__F1 ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions 9611 6198 9817 139341 PMC8896306__F4 Circadian rhythms and cancers: the intrinsic links and therapeutic potentials 5159 4485 9113 26524 PMC8897942__F1 MUC1 is a potential target to overcome trastuzumab resistance in breast cancer therapy 4582 2475 6774 1499 PMC8901598__F2 Metabolic and Epigenetic Regulation by Estrogen in Adipocytes 5468 10682 54790 6996 2078 23030 2146 155 1734 7350 1786 PMC8903576__F11 Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism 2475 3916 83939 468 6774 581 PMC8904240__F7 Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway 9474 596 8678 22863 30849 5289 PMC8904950__F5 Knockdown of TRIM44 inhibits the progression of ovarian cancer and is related to the FOXM1-EZH2 signaling pathway 9097 5887 79026 10075 867 4853 57761 5335 26027 6197 3398 5154 54765 2146 6925 6241 1756 7157 79733 200081 5054 4605 1602 3832 2305 332 1591 4172 780 6672 1059 1058 6015 PMC8905584__F7 To detect potential pathways and target genes in infantile Pompe patients using computational analysis 147111 9350 50964 25805 2040 6259 27130 324 6477 387 6500 9475 4089 4088 51701 PMC8906734__F1 FKBP51 associates with amino acids and polyamine biosynthesis pathways 7942 4553 6009 7249 PMC8907745__F2 Molecular Brakes of Adipose Tissue Lipolysis 3667 57104 1958 5140 134 PMC8908320__F8 Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas 995 7150 983 545 472 2475 PMC8909289__F1 miRNA-Dependent Regulation of AKT1 Phosphorylation 1950 5286 5163 167153 207 PMC8909308__F5 Transcriptome Differences in Normal Human Bronchial Epithelial Cells in Response to Influenza A pdmH1N1 or H7N9 Virus Infection 581 56616 2021 572 6955 54205 666 PMC8910853__F3 Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention 7040 581 23411 217 PMC8913022__F2 Statin Use in Patients With Chronic Liver Disease and Cirrhosis: Current Evidence and Future Directions 998 5879 10365 PMC8913803__F3 Signaling pathways and targeted therapy for myocardial infarction 283120 114548 100126333 693122 114609 4615 7189 PMC8914027__F6 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway 100506860 100506668 3192 10379 3609 3659 7297 1660 3716 3717 1386 5094 104326052 PMC8914108__F1 New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption 7019 3479 2475 5166 5208 2821 PMC8914342__F3 Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases 55364 100996301 7031 1994 4193 142 10664 PMC8924146__F4 MicroRNAs as a clue to overcome breast cancer treatment resistance 8205 693160 2078 6955 3480 442909 406928 2069 2059 7939 170 693215 1956 2475 5728 574493 PMC8925056__F8 TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes 85480 6389 65018 3627 6346 6367 PMC8927800__F1 Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway 3479 3667 8660 2475 5163 PMC8927800__F3 Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway 10225 572 842 3479 2475 PMC8928416__F4 NOD1 and NOD2 in inflammatory and infectious diseases 26353 10392 64127 8767 7186 8195 7187 55054 9474 3665 9140 57506 3661 PMC8929358__F4 Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping 7454 100187761 4397 PMC8933007__F4 Nicotinamide n-methyltransferase (NNMT) links nicotinamide adenine dinucleotide (NAD) and methionine metabolism during replicative senescence 4837 191 4548 4144 10135 64802 635 952 PMC8933845__F1 Immune Underpinnings of Barrett’s-Associated Adenocarcinogenesis: a Retrial of Nefarious Immunologic Co-Conspirators 57761 3553 834 3976 3569 3552 4513 PMC8940245__F3 Akt: A Potential Drug Target for Metabolic Syndrome 91653 5163 7038 3667 2308 5879 PMC8943211__F7 Monoacylglycerol acyltransferase pathway contributes to triacylglycerol synthesis in HepG2 cells 4018 7038 4247 PMC8944338__F4 Multi-protein complexes contribute to the Stimuli-Sensing Channels intracellular signaling pathway 84239 1182 161003 1186 717 10786 29850 54795 8989 7442 94015 80727 57348 PMC8945030__F1 Gene Variants Involved in Nonsense-Mediated mRNA Decay Suggest a Role in Autism Spectrum Disorder 54464 5976 56006 55181 23049 10921 26019 6426 355 9704 55629 22794 10856 9887 65110 26986 51594 PMC8945445__F2 Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols 3667 4615 7189 3606 PMC8945680__F1 NFKB Signaling and Inflammation—Drug Repurposing to Treat Inflammatory Disorders? 7124 613 10892 5970 7189 23118 10454 4050 5971 7186 7187 PMC8945958__F1 Ferroptosis in Cardiovascular Diseases: Current Status, Challenges, and Future Perspectives 6667 2182 10162 9817 3162 4015 8678 23657 6520 1719 2643 PMC8946083__F7 In Silico Analysis of Ion Channels and Their Correlation with Epithelial to Mesenchymal Transition in Breast Cancer 3767 3766 3757 57582 775 774 3780 207 7220 7225 2247 1956 3845 5594 2597 4609 3688 999 387 5728 3710 2868 1026 2902 2099 55107 2743 1185 3320 3725 6714 998 7157 1188 2697 2700 2706 170572 PMC8946555__F1 Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer 132 4922 100 952 PMC8948490__F1 Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts 4763 860 6010 998 PMC8949863__F3 Tug of War: Pseudorabies Virus and Host Antiviral Innate Immunity 3455 6773 10379 7297 9636 8638 3669 PMC8950598__F1 Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD 5966 7186 7185 717 23118 257397 8772 8717 1311 11035 197259 PMC8951683__F9 Effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathway 1499 3280 6662 176 6611 PMC8955027__F2 Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells 5834 5836 5236 2820 2821 2271 4191 5213 6390 7167 230 1737 1738 178 1431 3098 26227 2597 5230 5223 6888 2023 2026 2020 5315 5313 50 5160 5162 8050 6576 3418 3419 3421 4967 1743 37 8803 8802 8801 33 34 1892 47 35 48 1374 788 1384 3417 3032 3033 8540 2806 5214 9242 PMC8955204__F1 MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging 9927 407019 407009 3486 84676 5709 2475 3479 57521 5163 PMC8955653__F2 An Expanding Toolkit for Heterochromatin Repair Studies 7518 3981 5893 3980 3978 641 1763 472 675 5888 84126 545 9156 11073 PMC8955828__F1 Autophagy Pathways in the Genesis of Plasmodium-Derived Microvesicles: A Double-Edged Sword? 9474 4077 7939 PMC8959892__F2 Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy 10628 23411 23237 7099 4615 PMC8959940__F1 Microglia Polarization: A Novel Target of Exosome for Stroke Treatment 9023 7506 4851 10725 3654 23118 6778 4087 PMC8960266__F1 Imaging Sub-Cellular Methionine and Insulin Interplay in Triple Negative Breast Cancer Lipid Droplet Metabolism 80835 7249 5163 PMC8961648__F4 Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast 5105 2571 48 383 3417 PMC8964039__F2 Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases 497258 55384 105378558 2668 627 351 4137 PMC8964401__F7 Dynamics and Functional Interplay of Nonhistone Lysine Crotonylome and Ubiquitylome in Vascular Smooth Muscle Cell Phenotypic Remodeling 5132 6389 2597 1737 1431 3939 1743 7086 2539 25796 6120 5226 22934 1738 PMC8967065__F4 Relationship between PCP and cystogenesis 81839 7976 8323 PMC8967065__F5 Instructive cues establishing PCP during kidney development 7484 7477 7481 PMC8967653__F1 Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins 23194 351 5979 8642 79633 4485 7003 8463 7004 7005 474168 26524 PMC8968515__F9 Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis 2475 107966124 133 PMC8968680__F2 Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology 2475 572 842 4193 324 595 PMC8971671__F8 CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome 6376 6093 581 1524 387 4087 4088 4089 PMC8972192__F2 Exploration of Novel Pathways Underlying Irreversible Electroporation Induced Anti-Tumor Immunity in Pancreatic Cancer 54106 4615 9618 7189 3654 3458 3716 6772 3717 PMC8972237__F7 Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells 147111 1066 5447 50964 25805 6259 27130 23237 6477 324 29984 6500 8454 4088 51701 PMC8980014__F1 CSNK2 phosphotargets, associated pathways, and CSNK2-regulated phenotypes identified in this review 1956 5728 5163 2475 7249 7248 5970 8517 3551 1147 4792 4193 7157 6774 PMC8980477__F1 Contribution of Interleukin-17A to Retinal Degenerative Diseases 55540 9618 10682 84818 7186 7188 7189 132014 PMC8981087__F2 Autophagy in the Function of CD4+ T Cells and the Development of Chronic Inflammatory Diseases 920 4280 6098 960 581 578 PMC8984994__F1 Advances in understanding of the innate immune response to human norovirus infection using organoid models 7097 51284 3458 3459 3717 3460 6772 6773 3454 3455 7297 3716 PMC8987999__F2 Emerging diabetes therapies: Bringing back the Beta-cells 3479 2740 3480 3717 3667 1992 2932 5577 PMC8989428__F3 Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review) 6520 23657 468 2885 2879 581 847 PMC8989677__F8 Cartoon of mode of action of BNT162b2 in vivo 5132 3454 3455 3458 7097 11035 2638 920 PMC8989838__F6 Metabolic Reprogramming of Alloreactive T Cells Through TCR/MYC/mTORC1/E2F6 Signaling in aGvHD Patients 4609 940 5213 2597 PMC8990477__F2 CAR-T Cell Therapy for Breast Cancer: From Basic Research to Clinical Application 7157 2475 4609 596 PMC8991826__F9 TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway 2475 581 1000 999 595 PMC8994166__F5 Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation 4976 55669 9927 PMC8996108__F7 Blueberry Juice Attenuates Pulmonary Fibrosis via Blocking the TGFB1/Smad Signaling Pathway 641 999 6774 4088 4087 PMC8996529__F6 Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response 1384 790 7054 PMC8997157__F4 PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression 8660 998 5728 5163 PMC8998186__F3 Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response 1540 83737 3932 7535 56957 2534 8239 219333 PMC8998506__F3 Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease 10313 23621 9236 7494 25923 PMC8998691__F2 MicroRNAs Expression in Response to rhNGF in Epithelial Corneal Cells: Focus on Neurotrophin Signaling Pathway 23269 6955 6651 PMC8998816__F2 FTO m6A Demethylase in Obesity and Cancer: Implications and Underlying Molecular Mechanisms 79068 51441 5914 51676 1050 10481 6663 5133 7852 664 7593 2067 1869 3558 PMC8999811__F2 Jasmonate Signaling Pathway Modulates Plant Defense, Growth, and Their Trade-Offs 8454 81857 4609 PMC9000380__F1 Ferroptosis: A New Road towards Cancer Management 2879 2182 10162 2936 PMC9001082__F4 PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress 2475 4843 9817 196 PMC9001993__F5 2-Methoxy-1,4-naphthoquinone (MNQ) regulates cancer key genes of MAPK, PI3K, and NFKB pathways in Raji cells 208 8649 4791 369 8717 3845 3265 1958 3688 5925 2309 5728 4790 7157 1027 2353 2308 572 7533 673 PMC9003256__F8 Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop 581 27159 55669 9927 7019 4810 PMC9006445__F3 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies 545 1017 2475 358 8737 11035 197259 23657 6520 2879 8772 8717 1036 PMC9007519__F6 Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer 613 930 3667 5728 951 7249 572 4193 6009 2475 672 5934 150365 4602 1977 PMC9009237__F4 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications 114548 7124 3553 PMC9009531__F1 Lipid Metabolic Process Involved in Oocyte Maturation During Folliculogenesis 2181 2182 6296 95 1376 PMC9011221__F1 Critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review 2241 55240 8031 81539 2744 6510 3652 2879 2937 PMC9013079__F8 L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKBeta-AMPK signaling pathway 2475 2194 5465 7038 1374 PMC9013863__F4 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma 6774 442909 1021 1019 4193 596 581 595 PMC9018123__F4 Putative functions of EpsK in teichuronic acid synthesis and phosphate starvation in Bacillus licheniformis 3728 266710 1311 367 10487 4397 PMC9019367__F2 Research Progress of Epithelial-mesenchymal Transition Treatment and Drug Resistance in Colorectal Cancer 324 1499 4087 4088 4089 999 5163 PMC9020428__F2 Delivery of triptolide: a combination of traditional Chinese medicine and nanomedicine 572 5728 581 83939 PMC9022290__F2 CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate 1376 948 2180 2167 PMC9022965__F2 Four enzymatic pathways that drive PL remodelling 95 5091 127435 PMC9023073__F7 Mechanism of Lipopolysaccharide Escaping the Intestinal Barrier in Megalobrama amblycephala Fed a High-Fat Diet 27201 948 4583 PMC9023794__F1 Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection 83939 8772 27040 637 572 90427 638 8739 581 PMC9024145__F3 Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury 6387 55000 8266 665 285943 7852 255082 387066 7099 5584 5820 PMC9024538__F2 Targeting Wnt/Beta-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents 3725 4920 23002 387 998 PMC9024760__F1 Cell Culture Media, Unlike the Presence of Insulin, Affect Alpha-Synuclein Aggregation in Dopaminergic Neurons 2885 5728 2475 5163 PMC9027139__F1 O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications 2585 55577 6675 8473 PMC9027240__F2 Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors 6608 51684 374654 PMC9027827__F3 Advances in the development of new biomarkers for Alzheimer’s disease 4023 7124 407035 406957 841 8772 355 1020 637 2932 836 842 406921 94005 2475 100506742 PMC9027994__F1 Proline Metabolism in Malignant Gliomas: A Systematic Literature Review 29920 5625 65263 5184 PMC9028246__F2 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer 23286 154796 4771 84962 6714 2195 122786 57551 4485 60485 9113 55233 5163 6010 PMC9028246__F4 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer 8658 154796 6714 4485 60485 9113 55233 1956 5163 6010 PMC9028275__F3 Entanglement between Mitochondrial DNA and Tumor Metastasis 4541 7422 6354 3383 115004 54106 8205 5132 PMC9030030__F3 Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL Subsets 2322 3716 2475 572 PMC9031703__F7 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response 324 1499 2475 2962 2885 3667 5163 5728 PMC9031790__F2 Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents 468 22926 7494 PMC9032508__F2 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia 472 3091 7249 PMC9032508__F6 Metabolic Stress and Mitochondrial Dysfunction in Ataxia-Telangiectasia 717 718 3939 PMC9035423__F4 Lactate-induced effects on bovine granulosa cells are mediated via PKA signaling 1588 2492 3973 5997 8875 PMC9040349__F14 Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms 2621 8470 9844 30846 1400 4837 51378 64096 23336 55040 84894 57580 8821 493829 2675 90293 10603 51310 8527 92421 23541 84632 4440 10256 10887 80243 55544 PMC9041553__F2 Ex Vivo Test for Measuring Complement Attack on Endothelial Cells: From Research to Bedside 790 1356 718 2271 1378 1431 729 730 735 7448 5340 PMC9042931__F2 Schematic diagram illustrating intracellular pathways of NAD+ synthesis, NAD+ metabolism, and NAD+ signaling pathway in mitochondria 160728 84561 55315 3177 222962 2030 10135 203447 65220 581 23530 92014 23410 349565 PMC9042931__F4 Protein–protein interaction networks between NAD+ and associated regulatory proteins implicated in heart aging 100653365 3630 92335 2475 23410 355 5970 581 8772 PMC9043866__F8 TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NFKB pathway 836 581 3553 PMC9046545__F3 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review 10818 867 2885 2549 PMC9058112__F1 Cardiac Remodeling in Heart Failure: Role of Pyroptosis and Its Therapeutic Implications 338321 114548 171389 9447 22861 1687 58484 79792 3553 PMC9058838__F4 Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway 5837 3099 5236 2821 84706 226 2597 5230 5223 2023 5105 5315 189 158 1103 1120 56994 790 43 5337 445 435 8760 54675 2744 2752 79888 1373 253558 PMC9063253__F4 V-ATPase in cell death and cancer 6774 7009 8837 841 10018 578 8743 581 836 2879 768 7942 2475 30061 PMC9064286__F3 Determinants of tumor sensitivity to GLS inhibitors 5091 6513 2475 6510 2744 23657 3417 3418 2625 9817 PMC9064865__F5 6-Hydroxydopamine Induces Neurodegeneration in Terminally Differentiated SH-SY5Y Neuroblastoma Cells via Enrichment of the Nucleosomal Degradation Pathway: a Global Proteomics Approach 9365 2022 1311 PMC9072740__F4 Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context 6520 2879 10162 2182 8031 84883 7018 PMC9074313__F1 Functional roles of the circRNA/Wnt axis in cancer 2932 324 1499 6010 23002 PMC9075957__F3 Interacting genes form a diet-responsive network affecting adipogenesis 5552 5333 3074 8792 4826 3156 2149 1028 10682 PMC9077970__F1 Dual role of autophagy in acute myeloid leukemia 128338 1869 100506311 9474 PMC9077970__F2 Dual role of autophagy in acute myeloid leukemia 2322 23411 6774 468 5979 8408 5371 9474 10533 4609 7942 3417 3418 11059 PMC9085237__F1 Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties 472 7157 7248 7249 4193 1499 8714 595 1021 407040 558 1956 182 5054 960 8091 4851 8313 7471 6714 PMC9085237__F16 Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties 7248 7249 3099 3098 57103 6009 PMC9086968__F6 14,15-Epoxyeicosatrienoic Acid Protect Against Glucose Deprivation and Reperfusion-Induced Cerebral Microvascular Endothelial Cells Injury by Modulating Mitochondrial Autophagy via SIRT1/FOXO3a Signaling Pathway and TSPO Protein 4193 6839 7337 2033 2309 706 5468 10105 9575 1407 4087 7157 23411 2308 10891 4654 PMC9091111__F4 Curcumin treats endometriosis in mice by the HIF signaling pathway 246 4318 4843 9536 7099 5742 2932 240 6774 1956 3725 27306 8795 5328 4780 836 9212 1786 6198 4851 3163 999 6790 5465 3569 1544 3553 4322 5743 2064 598 1543 207 3066 3990 9429 7422 1950 2353 2308 5468 4170 3162 1026 2475 5111 898 595 4312 7157 842 4313 1499 4790 3091 5915 7442 7153 6462 PMC9091963__F1 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System 4513 545 1499 1636 PMC9091963__F9 Insights Into Vascular Anomalies, Cancer, and Fibroproliferative Conditions: The Role of Stem Cells and the Renin-Angiotensin System 4312 7421 6402 PMC9094703__F1 Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders 9575 4862 406 1407 6095 4128 4478 PMC9095362__F2 Cancer Stem Cell-Derived Exosomes in Cancer Progression 5728 80781 7058 2064 2065 1401 3717 6774 PMC9095362__F3 Cancer Stem Cell-Derived Exosomes in Cancer Progression 5728 1000 4088 PMC9095921__F1 Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke 4397 2695 6010 6348 PMC9096244__F3 Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma 2475 3667 7249 253260 5728 6194 572 PMC9099524__F5 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer 4513 3553 7189 23118 10454 6774 7428 1950 6714 PMC9099918__F1 Novel Therapeutic Approaches with DNA Damage Response Inhibitors for Melanoma Treatment 6741 84126 545 995 983 993 7465 1017 472 3014 7518 3981 PMC9101234__F6 Cardiac Fibroblast GLS1 Expression by Scleraxis 10965 230 2744 2875 PMC9104338__F9 In Vitro Effects of Papaverine on Cell Migration and Vascular Endothelial Growth Factor in Cancer Cell Lines 5728 2475 3146 596 10846 PMC9106060__F4 Determination of WWOX Function in Modulating Cellular Pathways Activated by AP-2A and AP-2G Transcription Factors in Bladder Cancer 27040 1610 1398 4937 718 355 23440 2695 5900 5548 5810 5310 6010 998 790 PMC9106063__F7 ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NFKB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation 4615 3553 7099 51135 929 7189 3656 3654 114548 3383 PMC9106601__F1 WNT and NOTCH signaling in human trophoblast development and differentiation 147111 324 1499 PMC9108753__F10 scEFSC: Accurate single-cell RNA-seq data analysis via ensemble consensus clustering based on multiple feature selections 7054 50964 25805 6259 11319 9615 27040 64806 5447 367 324 6500 4117 9760 9475 759 25776 51701 79866 PMC9108985__F1 Cellular proteostasis in antitumor immunity 338386 3297 22926 PMC9109253__F1 Novel Small Molecule Approach for the Treatment of Propionic and Methylmalonic Acidemias. 718 162417 1373 PMC9110515__F1 White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure 3667 7099 6347 PMC9110800__F2 Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases 2638 10664 4436 4437 PMC9112062__F7 Endothelial AMPKA1/PRKAA1 exacerbates inflammation in HFD‐fed mice 5562 47 2033 PMC9115384__F1 Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application 9706 9776 7405 22863 64422 10533 2475 55054 9474 9140 55014 4077 PMC9115384__F3 Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application 920 10533 3627 7939 6352 23192 6498 PMC9117765__F3 TEAD4 as an Oncogene and a Mitochondrial Modulator 60485 7004 9686 4485 9113 26524 4771 864 1499 6925 2475 PMC9118050__F2 Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities 6387 7852 7476 4087 4088 3419 3091 960 2191 2919 2920 4513 94241 7157 406938 407007 3930 10628 1499 1540 PMC9119177__F7 Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways 8213 929 7124 8717 57817 472 4599 PMC9120431__F3 Engineering GD T Cells: Recognizing and Activating on Their Own Way 11120 11119 8480 100507436 5091 3458 5111 1611 7409 2885 6850 7535 PMC9121581__F5 Potential effects and mechanisms of hispidulin in the treatment of diabetic retinopathy based on network pharmacology 613 930 6850 5728 951 7249 2475 572 4193 5934 1977 1537 PMC9124082__F7 Marine-Derived Stichloroside C2 Inhibits Epithelial–Mesenchymal Transition and Induces Apoptosis through the Mitogen-Activated Protein Kinase Signalling Pathway in Triple-Negative Breast Cancer Cells 717 999 581 891 1017 983 8900 PMC9126300__F1 Deciphering the Link Between ERUPR Signaling and MicroRNA in Pathogenesis of Alzheimer’s Disease 83939 468 7494 7186 PMC9128211__F1 Biology of YAP in programmed cell death 6714 81788 4609 78990 7227 51701 7074 864 6935 PMC9130080__F45 Triclosan-induced neuroinflammation develops caspase-independent and TNFA signaling pathway associated necroptosis in Neuro-2a cells 8717 7186 828 11035 8772 197259 841 PMC9130907__F1 Hemostasis and tumor immunity 8205 7018 5972 PMC9132047__F9 Study on the Mechanism of Sancao Tiaowei Decoction in the Treatment of MNNG-Induced Precancerous Lesions of Gastric Carcinoma Through Hedgehog Signaling Pathway 3549 6469 50846 6608 51684 1956 2475 PMC9133251__F6 Modified natriuretic peptides and their potential roles in cancer treatment 1267 6476 2638 PMC9136512__F10 CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth 80279 983 11200 1111 581 6154 2475 PMC9138678__F1 Brain-Derived Neurotropic Factor in Neurodegenerative Disorders 627 4615 2475 6714 1950 PMC9139230__F1 How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives 1956 1499 387 47 2475 6654 5163 3099 3939 2147 PMC9139943__F3 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance 6741 7515 2237 545 4361 9156 80198 PMC9142561__F9 Early molecular events leading to COFILIN phosphorylation during mouse sperm capacitation are essential for acrosomal exocytosis 387 3984 54434 367 PMC9144571__F2 Whole Aspect of Runx2 Functions in Skeletal Development 860 1749 5744 121340 1277 1278 8600 6696 3381 632 PMC9148527__F4 Plasmodium manipulates the expression of host long non-coding RNA during red blood cell intracellular infection 100187907 10468 3082 975 3458 7124 4052 1628 25805 2993 7054 7046 4838 8480 2821 387 4091 4092 4087 4088 7097 7099 9978 8454 6500 4089 6667 920 PMC9149431__F3 All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity 7186 1540 8717 355 197259 8772 637 PMC9150370__F2 Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms 5163 114548 2932 23410 PMC9154101__F7 HbF induction by SAL 83939 1386 468 1385 PMC9155915__F7 Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer's Disease Based on Network Pharmacology and Experimental Validation 5066 613 930 2885 5879 7249 2475 6009 572 51083 1977 1537 PMC9158441__F5 Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms 10454 7494 468 8772 637 22926 150365 1017 581 317 64422 10533 100187761 PMC9158441__F7 Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms 3099 5315 3939 2475 5163 PMC9160457__F9 Attenuation effect of potassium 2‐(1‐hydroxypentyl)‐benzoate in a mouse model of diabetes‐associated cognitive decline: The protein expression in the brain 3094 1821 28956 2475 3029 23122 PMC9161693__F1 Astrocytic Calcium and cAMP in Neurodegenerative Diseases 90550 1674 100 PMC9162454__F2 Pyroptosis is executed by the gasdermin pore-forming family of proteins 9447 79792 7124 355 1687 56169 55876 284110 581 PMC9163322__F1 Novel Immune Checkpoints in Esophageal Cancer: From Biomarkers to Therapeutic Targets 8205 3902 201633 PMC9166676__F4 Chemoresistance in cancer stem cells 217 4363 1499 9429 649 27122 998 581 7042 PMC9168430__F3 Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence 3620 196 7166 4280 PMC9169354__F1 Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer 4485 9686 9113 4771 26524 60485 PMC9170579__F5 Long noncoding RNAs (lncRNAs) in human lymphomas 100124700 673 2932 55384 2475 324 1499 286467 60674 8772 1019 1021 1017 728655 PMC9172199__F3 Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment 382 7251 928 967 975 PMC9177323__F6 Single-Cell Analysis Reveals the Role of the Neuropeptide Receptor FPR2 in Monocytes in Kawasaki Disease: A Bioinformatic Study 27101 811 5230 7037 1508 10097 7170 3936 7054 PMC9178120__F2 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors 8205 3569 3082 22943 6423 1237 1234 3586 1230 57823 3480 3383 7412 7852 PMC9179265__F1 EPA Modulates KLK Genes via miR-378: A Potential Therapy in Prostate Cancer 43847 9622 3817 5653 5294 10000 367 999 2885 5604 2475 PMC9179436__F2 Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment 50943 6774 8205 196 7474 89780 PMC9180607__F5 Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration 6670 6667 4088 3099 10413 5989 1490 4856 PMC9181451__F4 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases 51755 1642 9978 PMC9183106__F6 Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway 4193 581 596 PMC9184412__F2 Dopaminergic control of Cushing’s syndrome 1610 51083 2475 1958 PMC9184561__F7 Mechanism of sorafenib-inhibiting inflammation induced by LPS 3929 4067 23118 7189 3569 PMC9185410__F3 Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion 197259 90865 3146 PMC9191826__F9 Combined treatment with anti‐PSMA CAR NK‐92 cell and anti‐PD‐L1 monoclonal antibody enhances the antitumour efficacy against castration‐resistant prostate cancer 2475 4277 100507436 3716 3466 PMC9194136__F5 Exploring the metabolic landscape of pancreatic ductal adenocarcinoma cells using genome-scale metabolic modeling 3845 3939 47 2806 2194 4199 4118 PMC9199004__F7 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways 1759 998 6714 PMC9202500__F6 Functions of Viroporins in the Viral Life Cycle and Their Regulation of Host Cell Responses 7187 3661 29110 57506 64127 1956 56832 3454 10379 3836 PMC9203694__F5 Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies 472 5058 142 22880 983 PMC9204485__F1 Love-Hate Relationship Between TGFB Signaling and the Immune System During Development and Tumorigenesis 4089 7939 4087 4088 5045 7018 2885 7189 2475 6010 PMC9204593__F2 Transient Receptor Potential Channels, Natriuretic Peptides, and Angiotensin Receptor-Neprilysin Inhibitors in Patients With Heart Failure 1636 5225 1267 759 PMC9212771__F6 In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19 5185 718 6667 100187907 7939 572 79596 3976 PMC9214030__F2 From a Hetero- to a Methylotrophic Lifestyle: Flash Back on the Engineering Strategies to Create Synthetic Methanol-User Strains 3034 7086 6120 4049 2875 183 10588 PMC9217905__F1 Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review 1499 324 595 4513 4316 PMC9217905__F6 Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review 1499 324 595 4513 4316 PMC9218220__F3 Reactive Oxygen Species and Metabolism in Leukemia: A Dangerous Liaison 50508 27035 79400 50507 53905 50506 2597 5164 11113 PMC9219782__F1 Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men 9825 1540 8737 7186 8717 7124 23118 10454 29110 331 90268 79792 8772 836 11035 197259 PMC9221389__F8 Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction 1326 929 9261 3725 4803 3304 4137 1956 6722 5598 207 5602 4609 9020 5605 5880 22800 5566 10000 208 177 PMC9221389__F9 Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction 4615 114609 842 6010 4214 2695 PMC9221635__F2 Telomere Maintenance and the cGAS-STING Pathway in Cancer 7015 5888 7012 54433 1736 55651 55505 472 23411 2618 PMC9222487__F8 Comparative Transcriptome Analysis of Organ-Specific Adaptive Responses to Hypoxia Provides Insights to Human Diseases 7099 3939 6774 5163 2689 7012 4149 PMC9225917__F12 Huangqi Sanxian Decoction Inhibiting Osteoclast Differentiation Based on Network Pharmacology 7097 7099 613 6850 930 2885 5879 7249 2475 6009 572 4609 4602 PMC9227908__F4 Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches 23479 2194 2475 3098 3099 PMC9227929__F2 Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases 169355 3620 3398 PMC9228484__F1 Virus–Host Interplay in Junín Mammarenavirus Infection 2060 3067 2813 PMC9231409__F1 Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options 7098 7706 23636 4928 29110 57506 3661 9636 10482 29107 6772 3454 7297 6773 10379 PMC9234166__F1 Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy 7038 3419 80724 7381 2110 6648 2230 4714 6389 84869 84816 7001 1346 5160 1728 4726 1345 2876 84263 7498 2879 4697 622 35 3939 10327 PMC9238352__F4 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways 3929 4049 4050 7124 5447 613 10913 8717 100187907 27040 1540 759 637 1431 9015 472 331 PMC9240190__F2 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy 3667 8660 5728 5163 2932 PMC9240468__F5 MIR4435-2HG Is a Potential Pan-Cancer Biomarker for Diagnosis and Prognosis 4485 60485 9113 26524 10413 6489 4904 324 4193 8324 1832 1499 7046 4087 1874 541471 PMC9241412__F2 Regulatory role of Pin1 in neuronal death 1616 581 5300 PMC9242006__F1 Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression 2247 6857 6274 3553 2246 8877 3416 2167 8322 925 6647 1080 PMC9243238__F3 Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification 7494 83939 468 22926 PMC9245541__F2 How Do Pollen Allergens Sensitize? 920 940 941 912 85480 64806 90865 942 PMC9247141__F3 Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis 4780 27165 6520 23657 2879 6303 1803 112812 2230 81894 PMC9249506__F10 Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response 472 1263 581 596 PMC9252739__F1 Shiny GATOM: omics-based identification of regulated metabolic modules in atom transition networks 375775 55512 5223 2023 5315 9524 79603 51102 10449 2581 5167 5236 3795 230 5019 51380 7086 445 8801 2806 47 22934 5634 3417 7372 6240 48 10135 4942 8659 2937 4259 PMC9258583__F8 Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress 286204 5888 1040 80198 54617 PMC9259182__F6 Identification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach 836 6401 7412 1906 3383 7018 PMC9263642__F5 UVB irradiation differential regulate miRNAs expression in skin photoaging 7124 695 355 929 8717 7186 1616 23118 51295 5624 3240 5894 351 57136 2316 4351 51701 2002 3725 4149 4208 6722 PMC9265296__F1 New Insights into Hippo/YAP Signaling in Fibrotic Diseases 4485 60485 9113 7003 7004 PMC9265870__F1 Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications 1499 324 81606 693185 6657 9794 3714 182 8650 5727 2735 2737 2736 2296 6608 5970 79923 5971 PMC9265870__F2 Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications 718 3082 6347 3953 3574 182 6935 9474 PMC9267302__F6 Investigation of the Molecular Mechanisms Underlying the Antiatherogenic Actions of Kaempferol in Human THP-1 Macrophages 4878 2778 100187761 5587 759 5598 23209 6885 4879 5743 5609 6416 1386 3725 93649 5290 3976 6202 PMC9267699__F2 New Avenues of Heme Synthesis Regulation 3145 7390 7389 2235 1371 7054 5498 PMC9270260__F12 Novel antiproliferative PKCAlpha-Ras-ERK signaling axis in intestinal epithelial cells 2885 6654 595 3397 3265 25780 PMC9270554__F7 Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria 4199 230 226 5230 3939 5315 2937 5163 2936 3157 4967 47 2194 PMC9270569__F1 Cardiovascular Disease in Duchenne Muscular Dystrophy 6262 5350 90550 PMC9271392__F3 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk 4040 4041 324 1499 1431 PMC9271392__F5 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk 4617 4040 4041 324 1499 1431 PMC9271392__F6 Importance of Sclerostin as Bone-Muscle Mediator Crosstalk 4617 324 1499 4087 1431 PMC9271773__F5 Targeting Adenylate Cyclase Family: New Concept of Targeted Cancer Therapy 55384 4609 51548 1956 PMC9271918__F1 Molecular Mechanisms of Plant Responses to Salt Stress 207 51411 6655 6654 PMC9272004__F2 Heme Synthesis by Mitochondrial Homeostasis Proteins 54977 3145 10845 7390 7389 51522 10058 1371 5498 2235 23456 PMC9273593__F6 Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications 3082 2833 2919 2744 3553 PMC9274112__F1 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy 4087 4088 7099 4615 3661 7189 PMC9274112__F2 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy 79792 3554 4615 7189 PMC9280480__F2 SUMOylation Targets Associated With Wnt/Beta-Catenin Pathway 1616 4089 4088 4040 4041 6925 5903 960 324 PMC9285394__F6 Vascular smooth muscle cells in the development of aortic aneurysms and dissections 2200 4087 4088 7046 7048 5592 4089 4638 59 PMC9292562__F3 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing 952 7226 10135 50943 3553 PMC9292703__F1 Tryptophan‐derived serotonin‐kynurenine balance in immune activation and intestinal inflammation 15 3620 8564 PMC9293965__F2 Clusters of significantly enriched biological pathways for AD and GERD 7054 7549 147948 PMC9294282__F3 Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair 324 9025 165918 3981 7518 55183 55294 9817 29128 675 79728 672 51444 6047 55159 8237 5888 9156 PMC9296991__F1 Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations 7099 4843 9021 3566 PMC9301190__F2 Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies 961 207 208 3717 6774 8205 968 1436 1950 9332 729230 6347 6387 7852 PMC9302585__F1 Extraglycemic Effect of SGLT-2is on Mineral and Bone Metabolism and Bone Fracture 846 5741 140803 56302 PMC9305664__F2 Non-Coding RNAs in Primary Biliary Cholangitis 10716 60436 4087 7124 5132 PMC9305838__F3 Dual Function of Par3 in Tumorigenesis 387 57154 9113 6657 324 6774 5879 7074 PMC9306018__F1 Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes 59341 387 4040 4041 1499 50964 PMC9309601__F2 Cytokine storm: behind the scenes of the collateral circulation after acute myocardial infarction 3553 7046 5266 4087 94 4090 4086 6347 729230 PMC9311382__F1 Gut microbiota in sarcopenia and heart failure 367 207 2475 4087 4088 3480 3569 7124 84676 3554 664 PMC9312905__F7 Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry 6786 7038 7225 PMC9312948__F2 Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors 3091 4609 10131 6714 23410 PMC9313042__F1 Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases 4615 3654 51135 7189 10068 3458 7054 PMC9313263__F6 High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer 1950 1956 6194 PMC9313309__F2 Mouse Models for Application in Colorectal Cancer: Understanding the Pathogenesis and Relevance to the Human Condition 387569 324 3845 1499 4513 1901 6774 8877 PMC9313589__F1 Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma 197259 11035 581 2879 PMC9313589__F2 Pharmacological targets for the induction of ferroptosis: Focus on Neuroblastoma and Glioblastoma 197259 11035 581 2879 PMC9316217__F9 Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells 847 7124 3553 PMC9316959__F6 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma 2539 226 2597 92579 1431 2997 PMC9317521__F3 New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer 1581 1582 1593 8213 9420 PMC9318366__F6 Inosine Pretreatment Attenuates LPS-Induced Lung Injury through Regulating the TLR4/MyD88/NFKB Signaling Pathway In Vivo 25801 4353 847 PMC9319476__F2 Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta 324 22943 1499 PMC9321602__F1 Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy 7518 3981 286257 672 10111 4361 142 2237 3980 7515 5888 79728 641 9156 1763 5893 3978 PMC9322024__F2 Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress 9817 2810 23411 7942 2475 7415 PMC9325157__F2 Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19 59272 10379 7099 57506 29110 10010 7098 51311 51284 7297 3716 6773 6772 PMC9325518__F1 Role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma 2597 2023 226 2539 5163 389421 79727 202299 100124700 378938 100885779 3480 4609 2475 100113391 5728 PMC9326111__F6 Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer 572 7442 637 90550 581 55503 PMC9327618__F3 Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review 3553 3569 5971 PMC9331212__F1 Precision Medicine Highlights Dysregulation of the CDK4/6 Cell Cycle Regulatory Pathway in Pediatric, Adolescents and Young Adult Sarcomas 894 595 896 2475 1019 1021 1017 9134 PMC9331395__F6 Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase 4436 2956 4292 5395 142 10038 8505 4255 7515 PMC9331907__F3 Metabolism on Macrophage Polarization Under Different Disease Backgrounds 2539 355 3553 PMC9332053__F1 MTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data 671 6009 2475 64798 64223 7248 6446 253260 3553 PMC9340492__F1 Zebrafish models of inflammation in hematopoietic development and disease 3569 3553 3458 2313 29110 861 2624 7317 3716 10379 3717 6850 4067 PMC9343627__F1 Activation of STING Based on Its Structural Features 115004 29110 3661 6772 6773 10379 PMC9347104__F1 Oxalate-induced apoptosis through ERS-ROS–NFKB signalling pathway in renal tubular epithelial cell 1998 22926 7494 PMC9349561__F5 Exploration of molecular targets and mechanisms of Chinese medicinal formula Acacia Catechu ‐Scutellariae Radix in the treatment of COVID‐19 by a systems pharmacology strategy 847 8178 930 6652 7186 4099 4703 9049 83737 7249 54623 572 100187761 672 5934 717 133418 4323 64127 6401 6770 PMC9350527__F1 Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile Acids 1581 1582 1593 25801 8213 9420 PMC9352111__F4 Opioid signaling pathway: Males 7-week green module 673 100187761 7054 572 PMC9352111__F5 EIF2 signaling pathway: Male 2-year turquoise module 9118 43 7054 PMC9354016__F2 The mucin-like glycoprotein FCGBP in mucosal immunity and cancer 8857 4583 7033 3565 PMC9354910__F3 Common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19 2147 2920 58191 3627 847 3952 2475 3717 3107 3105 3630 3106 7297 196 PMC9355085__F3 Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity 324 920 253260 2475 940 406949 407021 50943 406952 6304 7908 3662 5971 7046 2932 406940 1789 1786 5212 638 PMC9355246__F2 Regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling 64223 64798 2475 6009 1977 8408 9776 5728 6446 PMC9355307__F4 Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues 5817 9531 6667 7150 4893 23200 7728 387921 6374 975 1604 10097 1667 103 6732 10346 1147 351 10875 7173 2017 4193 29110 4179 3265 6648 10135 5155 3454 253260 3459 5742 4088 6845 5660 306 353 102 2495 10857 353189 3837 8773 317 5476 57826 8836 4311 26578 10213 948 7414 3934 567 4048 1432 4352 4023 8743 5894 3460 7099 4332 5594 25798 9218 6993 58485 100302187 5719 7879 11031 5873 10890 326624 PMC9357935__F2 Research Progress of Myocardial Fibrosis and Atrial Fibrillation 7099 4615 7124 PMC9358040__F4 Dysregulation of Subcutaneous White Adipose Tissue Inflammatory Environment Modelling in Non-Insulin Resistant Obesity and Responses to Omega-3 Fatty Acids – A Double Blind, Randomised Clinical Trial 7473 7481 168002 8321 7855 6423 6424 4035 4040 1452 7040 6714 1499 324 10297 7157 5914 6929 6938 6942 150921 100129107 6934 595 4316 960 PMC9360701__F2 Hypothesized neuroprotective effect of minocycline against COVID-19-induced stroke and neurological dysfunction: possible role of matrix metalloprotease signaling pathway 4323 4313 5045 5340 4314 3553 4318 PMC9362873__F1 LILRB4, an immune checkpoint on myeloid cells 11006 10288 383 7054 8205 348 613 PMC9363460__F2 Key steps of the mevalonate (MVA) pathway leading to sterol and non-sterol isoprenoid synthesis 47 9023 1583 4047 3156 2224 3949 PMC9363460__F3 Non-exhaustive scheme of lipid exchanges between tumor cells and tumor microenvironment (TME) cells and lipid reprogramming of stromal cells, that activate their pro-tumoral features 8205 19 9619 4018 1839 348 3949 948 PMC9366252__F3 Progress of tumor-associated macrophages in the epithelial-mesenchymal transition of tumor 7046 7049 4089 4087 4088 8205 3725 324 1499 999 1000 7448 2475 PMC9366916__F3 Breaking the aging epigenetic barrier 472 10111 545 PMC9367355__F4 The Cancer Stem Phenotype by Long Non-Coding RNAs 283120 1499 3065 11331 PMC9367355__F5 The Cancer Stem Phenotype by Long Non-Coding RNAs 283422 5230 2146 5728 PMC9367608__F1 Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma 2806 2194 3099 2539 3939 PMC9367915__F2 Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer 367 4485 472 26524 8405 2078 545 5728 4851 4750 9874 28514 182 100188776 PMC9368818__F3 Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy 7157 4194 6873 27097 4193 6874 6883 6878 10629 54457 51616 83860 6881 6872 6884 129685 6908 8148 9014 79101 9015 PMC9368818__F9 Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy 7157 6880 51499 836 PMC9369058__F6 Spotlight on Exosomal Non-Coding RNAs in Breast Cancer: An In Silico Analysis to Identify Potential lncRNA/circRNA-miRNA-Target Axis 666 3952 59330 2475 100188776 675 5728 4117 388324 PMC9369281__F2 MicroRNAs in Inflammatory Bowel Disease and Its Complications 5728 5163 10401 6774 8651 64236 PMC9370123__F2 Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies 5981 121278 7054 4524 4397 875 PMC9370360__F4 Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases 351 83939 1998 PMC9376115__F6 Regulated cell death (RCD) in cancer: key pathways and targeted therapies 8314 467 2879 8031 5447 4015 10162 2182 9817 PMC9378677__F8 Schematic view of cell death signaling induced by 5’-ppp-RNA, cytosolic dsRNA, and extracellular dsRNA 3661 842 841 7098 8772 PMC9380933__F1 mRNA expression of NLRP3 and associated signalling molecules are differently regulated after SE elicited by pilocarpine or kainic acid 3146 7099 114548 834 3553 3606 PMC9381797__F1 Insulin signaling pathway was found to be associated with cerebrovascular pathologies in AD including inflammation, BBB disruption, and AB accumulation 7412 5163 2885 5728 2932 283871 PMC9382309__F3 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression 4193 1655 10521 PMC9382309__F4 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression 324 1499 10521 1655 6925 5970 PMC9382309__F6 DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression 999 10521 29102 54487 PMC9382640__F2 Mechanisms and prospects of circular RNAs and their interacting signaling pathways in colorectal cancer 2475 2932 5163 PMC9386081__F1 Non-coding RNAs in necroptosis, pyroptosis, and ferroptosis in cardiovascular diseases 8717 197259 11035 114548 140609 79792 1687 2879 PMC9389045__F6 Identification of Potential Ferroptosis Key Genes in the Pathogenesis of Lumbosacral Spinal Root Avulsion by RNA Sequencing and Bioinformatics Analysis 3939 5898 5160 6923 275 1387 7076 2056 1957 6513 4846 7010 596 3098 2597 PMC9389066__F1 Pyroptosis and inflammasomes in diabetic wound healing 7124 114548 9447 147945 22861 PMC9389448__F3 Modes of action and diagnostic value of miRNAs in sepsis 929 406913 4615 51135 114609 3654 3656 7189 23118 257397 10454 7124 693164 PMC9393224__F3 RNA binding proteins in osteoarthritis 2521 9444 8817 8148 7538 6662 677 54915 4691 26354 596 7099 PMC9393691__F4 Metabolic rewiring directs melanoma immunology 196 3902 920 50943 PMC9393846__F1 Chromosome instability and aneuploidy as context-dependent activators or inhibitors of antitumor immunity 115004 324 4035 100507436 4277 1786 PMC9395612__F2 Research progress on exosomes/microRNAs in the treatment of diabetic retinopathy 4087 4088 4089 5728 5163 7124 8717 7186 55816 PMC9395689__F6 RAGE pathway activation and function in chronic kidney disease and COVID-19 6347 3383 3146 1729 PMC9396537__F4 Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming 355 23410 23411 2475 PMC9396912__F2 Ferroptosis in esophageal cancer 23657 6520 2879 3458 3459 6772 3460 PMC9399134__F1 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis 960 7448 718 4089 7939 387 PMC9399134__F2 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis 545 472 4609 2522 998 961 325 3146 PMC9399134__F5 Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis 6935 6657 999 3861 7431 7291 7422 828 4609 231 PMC9399684__F2 Modulation of ion channels in cancer chemo-resistance 51393 145258 572 581 1499 6657 79923 9314 367 4193 960 PMC9399743__F1 Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism 130749 2078 6608 3652 2922 PMC9403721__F1 Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds 9140 8408 83734 10533 7405 9706 60673 9776 64422 PMC9405736__F1 Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage 22937 2744 4117 2194 6319 6576 47 8694 55902 3156 6646 2224 6713 3949 19 PMC9406534__F2 TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer 7186 23118 10487 10486 5971 PMC9406569__F5 Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers 1513 7249 7248 6009 2475 PMC9406587__F3 Proteostasis Deregulation in Neurodegeneration and Its Link with Stress Granules: Focus on the Scaffold and Ribosomal Protein RACK1 468 7494 22926 1998 10399 2475 PMC9406872__F2 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer 5728 2735 5727 64399 2475 2736 PMC9406959__F2 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma 51684 374654 6608 2736 2737 PMC9406959__F4 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma 182 3714 100188776 PMC9406959__F8 Current Opportunities for Targeting Dysregulated Neurodevelopmental Signaling Pathways in Glioblastoma 5950 64220 8854 216 220 1382 PMC9406970__F2 Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer 207 2670 23239 PMC9407090__F2 Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure 2776 5594 5330 2767 23236 3709 5581 2891 5604 2774 7175 3710 PMC9408811__F4 Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? 3554 4615 3550 7189 84818 PMC9408967__F9 Dentin Particulate for Bone Regeneration: An In Vitro Study 4487 860 1499 81861 100499166 324 PMC9409318__F7 Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARG and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes 8408 9776 1356 351 1977 7249 7248 6009 55615 7096 7097 51311 7100 7099 6010 383 7157 PMC9411667__F2 Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis 4091 4092 4851 114548 4855 4089 7189 4615 4118 2475 6772 6774 6778 3716 3717 3718 PMC9411667__F3 Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis 4615 114548 7189 9817 571 3162 3716 3717 6772 6774 6778 2475 3718 PMC9412181__F1 Overexpression of enzymes in glycolysis and energy metabolic pathways to enhance coenzyme Q10 production in Rhodobacter sphaeroides VK-2-3 4598 4967 1743 6389 47 1737 83440 2645 2821 2597 PMC9415417__F2 Calcimimetics in Treating Bone and Mineral Disorders Related to Chronic Kidney Disease 846 7480 581 2475 4772 PMC9416350__F2 Peptide-Based Vaccines in Clinical Phases and New Potential Therapeutic Targets as a New Approach for Breast Cancer: A Review 940 941 920 6351 6348 4283 3627 6373 PMC9418002__F2 BCL-2 family proteins 581 572 6850 613 695 5366 637 958 596 604 4303 1977 2309 7852 643 3565 3569 90427 4615 597 PMC9420941__F4 Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases 9817 2876 1728 PMC9423733__F1 Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease 8408 9706 9776 60673 55626 64422 10533 9140 9474 83734 PMC9424672__F5 Cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma 1325 1392 7124 PMC9425624__F2 Mast Cells in the Pathogenesis of Pruritus in Mastocytosis 83737 4803 117194 10203 10267 PMC9428632__F4 Roles of glycolysis in osteosarcoma 79804 4920 1956 2475 PMC9434120__F2 Relationship between metabolic reprogramming and drug resistance in breast cancer 3688 2475 1499 PMC9434538__F2 JMJD family proteins in cancer and inflammation 4088 3662 4199 23210 4200 PMC9437103__F2 Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics 3479 3480 5728 5163 PMC9437119__F8 Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics 64786 51024 4282 56947 PMC9437339__F9 Apolipoprotein A-I mimetic peptides (ApoAI MP) improve oxidative stress and inflammatory responses in Parkinson’s disease mice 2908 2288 3931 336 1956 10273 10598 4018 11140 3320 1839 5335 345 4841 338 2033 847 959 3552 3554 23411 6774 51022 9973 6649 8771 2937 3553 PMC9441765__F3 Emerging roles of ferroptosis in glioma 23657 6520 8678 2879 2182 10162 8651 PMC9441916__F5 Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy 8435 3702 23476 9774 1493 50615 3689 8726 2268 6404 3109 972 219972 5777 26191 23149 7185 1234 8698 4049 865 30009 3458 864 PMC9445553__F4 Immune responses to different Uropathogens call individual interventions for bladder infection 7099 84659 64127 3151 PMC9446754__F5 CD47 as a promising therapeutic target in oncology 961 664 54468 PMC9450390__F2 DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy 2932 6741 6772 6774 3659 3146 7099 4615 115004 57506 29110 3661 4283 3576 3458 PMC9450835__F10 Summary illustration of the phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair 55361 5007 9218 PMC9452304__F1 Complete biosynthetic pathway for the production of vinblastine in yeast 130 3652 3422 PMC9453478__F1 Fanconi anemia and dyskeratosis congenita/telomere biology disorders: Two inherited bone marrow failure syndromes with genomic instability 57697 2177 91442 55215 84464 51455 9156 6117 79728 5889 PMC9454096__F1 Evasion of interferon-mediated immune response by arteriviruses 6667 57506 3661 3665 7098 7189 6671 10010 6773 6668 9636 PMC9454566__F7 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response 10018 54809 94240 3594 4938 3434 684 7020 4940 1488 PMC9455514__F4 Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer 648 8473 84759 10336 84108 894 9839 595 960 387 389 891 6935 5728 4053 999 PMC9456253__F4 Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons 6194 6135 4736 1385 7157 6122 5970 2005 7528 6175 4205 7025 6128 6125 6772 2300 6137 860 2624 3172 6721 1820 2908 2295 5468 6202 5452 4790 3660 4800 7020 6229 4899 1869 3169 6722 1876 2099 6774 6881 6878 2002 6883 6872 2019 7022 3725 6874 102157402 6882 5076 8626 2625 7392 6877 6879 51690 579 4149 30832 4782 PMC9456256__F2 Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain 1431 23152 47 1103 355 PMC9456295__F2 Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory 1977 4553 2475 1938 PMC9456568__F2 NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets 673 10135 7099 1234 9242 PMC9458863__F3 Current progress of ferroptosis study in ovarian cancer 875 8324 23657 2879 6520 2182 1956 2475 79623 6502 PMC9459389__F3 Mechanisms of ferroptosis and its role in alzheimer’s disease 10162 2879 2744 5045 2932 847 23657 PMC9459608__F1 Kisspeptins and norepinephrine regulate different G-protein-coupled receptor signaling pathways 6714 1956 156 3164 2475 51421 55243 60485 4485 9113 26524 PMC9461128__F5 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential 7018 79047 284252 8089 10370 PMC9461655__F9 Novel methylated cation channel TRPM4 inhibited colorectal cancer metastasis through Ca2+/Calpain-mediated proteolysis of FAK and suppression of PI3K/Akt/mTOR signaling pathway 54795 84876 6786 4318 4313 2475 999 PMC9464960__F3 MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives 10554 8694 7528 23411 63924 6095 283131 2744 6510 6722 5971 5033 1316 2335 3638 PMC9465159__F1 Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy 7124 115004 57506 3661 3665 3569 3553 472 3656 3654 51135 4615 7187 6741 3565 545 142 7465 PMC9465375__F4 Roxadustat: Not just for anemia 596 6648 7295 PMC9469581__F5 TRIM proteins in hepatocellular carcinoma 81786 10155 11074 8805 51592 131405 5371 7157 84851 22954 54765 286827 201292 9866 23237 4591 4088 4087 4089 581 5728 7249 6714 7706 PMC9475358__F2 Tumor and Metastasis Initiation by Chemokine Receptors 6387 7852 6608 PMC9477010__F3 Pyroptosis and its crosstalk with immune therapy in breast cancer 56169 6774 55384 3717 581 114548 79792 9447 1687 1813 PMC9478452__F1 Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction 324 1499 595 3479 3480 7249 7248 64798 6774 2002 2885 2549 253260 3976 3977 4513 4609 1017 7124 331 958 6863 4055 1540 7186 7187 5971 4295 PMC9479684__F4 When does hepatitis B virus meet long-stranded noncoding RNAs? 359806 100124700 283120 1385 5111 100033819 100316868 5465 3209 2475 728655 8520 PMC9480797__F3 Molecular pathways in glioblastoma-derived stem cells to identify effective drug agents: A bioinformatics study 7015 1736 4605 7153 1031 890 2305 55055 81624 891 1062 11004 91754 9493 10051 1058 10112 10926 23397 55839 81930 56992 6790 79866 4751 1894 PMC9482125__F11 CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells 6667 387 466 595 857 6469 PMC9482317__F2 TGFB signaling in the tumor metabolic microenvironment and targeted therapies 4089 4087 4088 2475 6502 PMC9483553__F2 Prominent Role of miR-942 in Carcinogenesis of Tumors 2672 6424 2932 7088 324 116071 1740 25805 4153 50484 3170 8450 286 2619 2668 9021 5080 57573 60529 6299 80344 PMC9485571__F1 Uncovering incontinentia pigmenti: From DNA sequence to pathophysiology 8517 5970 3552 3553 PMC9491571__F2 Over- and under-expressed genes are highlighted in WNT signaling pathway 147111 9350 25805 2040 27130 717 367 324 9475 6500 8454 4089 4088 51701 PMC9493050__F7 Calcium dobesilate efficiency in the treatment of diabetic kidney disease through suppressing MAPK and chemokine signaling pathways based on clinical evaluation and network pharmacology 836 8717 3725 207 208 10000 3303 7186 3265 2885 5894 6352 6714 PMC9494158__F4 Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms 6774 7099 4615 23118 10454 PMC9496700__F1 Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma 55000 6238 8519 54997 891 2045 642587 283120 2475 51135 1977 PMC9496732__F3 Regulating the Expression of HIF-1A or lncRNA: Potential Directions for Cancer Therapy 999 6935 1000 PMC9497674__F9 Gene Expression Profiles of Human Mesenchymal Stromal Cells Derived from Wharton’s Jelly and Amniotic Membrane before and after Osteo-Induction Using NanoString Platform 10683 54567 6868 196403 9794 84441 2033 4853 3516 3955 8650 9253 55851 5664 5663 23385 3065 3066 1487 1488 9612 8061 9541 23220 8850 4854 890 3280 PMC9497807__F4 Polycomb Directed Cell Fate Decisions in Development and Cancer 6347 100507436 3627 3458 100187761 9332 3586 6346 10563 6361 6369 2146 8320 50943 3559 3399 920 8650 2625 355 PMC9499983__F6 RNA modifications: importance in immune cell biology and related diseases 8205 79068 3297 51441 54915 23091 10643 10128 56339 4904 23378 51605 54931 10644 920 11278 91746 200734 619501 3726 54888 23435 6774 57721 10148 4234 10785 PMC9500434__F8 Fucoxanthin prevents breast cancer metastasis by interrupting circulating tumor cells adhesion and transendothelial migration 3383 7412 1072 6935 1000 1499 PMC9500642__F8 Lysophosphatidic Acid Promotes Epithelial–Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy 999 4018 688 PMC9501144__F5 Resveratrol and Some of Its Derivatives as Promising Prophylactic Treatments for Neonatal Hypoxia-Ischemia 4899 23411 4204 627 581 PMC9502483__F2 Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease 114548 949 7099 948 4318 4035 PMC9502831__F1 Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering: A Literature Review 324 1499 4040 4041 4091 PMC9503744__F1 Crosstalk between Ca2+ Signaling and Cancer Stemness: The Link to Cisplatin Resistance 581 545 842 836 4193 PMC9504325__F1 Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies 10392 1673 6651 1509 PMC9505822__F1 Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer 55775 6741 55364 PMC9507923__F2 QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology 1956 7124 351 8139 PMC9508091__F1 Mutant KRAS mediated metabolic alterations 3098 2805 4199 3939 2746 2744 PMC9508091__F2 Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma 64841 6675 8473 PMC9509045__F5 Bioinformatic identification of differentially expressed genes associated with hepatocellular carcinoma prognosis 2932 4998 4999 23595 5000 6502 1874 4087 4088 4089 1017 1869 990 4193 5111 8318 8317 10926 993 699 4661 9184 5347 9126 929 PMC9509681__F7 Relevance of Host Gut Microbiome Signature Alterations on de novo Fatty Acids Synthesis in Patients with Multi-Drug Resistant Tuberculosis 47 6576 355 PMC9511957__F6 Toll-like receptor 2 signaling pathway activation contributes to a highly efficient inflammatory response in Japanese encephalitis virus-infected mouse microglial cells by proteomics 7097 4615 51135 7189 PMC9512455__F7 Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice 8213 1581 570 PMC9512540__F3 Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer 143686 23553 2905 494197 345651 340152 3698 22875 7079 4879 353189 377007 387273 57823 56256 83699 174 2243 10682 2153 54809 84674 2266 7078 27063 2635 4674 2744 2165 6289 6947 5210 4319 6567 26166 91543 139067 79413 11010 650 10877 9615 23554 834 64135 6373 3627 3767 2634 10878 84517 1672 83690 94241 3732 115361 157773 3624 353132 6383 1230 945 168002 355 10871 54544 3552 5473 5099 56062 80117 196264 404203 3853 114757 1645 9182 718 56954 146760 53836 1761 4359 10745 27012 5366 4477 145741 PMC9513364__F3 Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review 121340 1499 4090 4086 650 659 860 7046 7048 PMC9513389__F1 Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury 55240 2182 10162 5447 2879 1723 PMC9513432__F4 How sphingolipids affect T cells in the resolution of inflammation 4088 2475 3569 3586 50943 PMC9521765__F1 Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications 4092 64750 4089 4087 4088 2885 6009 5163 5728 7249 7248 1499 324 6774 PMC9522762__F2 Liver kinase B1 in tumor progression through regulation of lipid metabolism 948 23387 23235 200186 9759 2539 6733 2475 2194 47 PMC9523645__F7 SARS-CoV-2 Nsp6-mediated disruption of glycolysis 7027 23269 84108 4609 4149 3073 2645 PMC9526673__F6 Identification of Interleukin-1-Beta Inhibitors in Gouty Arthritis Using an Integrated Approach Based on Network Pharmacology, Molecular Docking, and Cell Experiments 53918 6955 7054 PMC9530249__F3 NFKB and its crosstalk with endoplasmic reticulum stress in atherosclerosis 50507 22926 7494 2932 85451 57506 7186 10392 468 114548 83939 10206 3553 PMC9530455__F4 mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma 100187761 5697 5831 7068 PMC9530954__F12 Identification of the molecular subgroups in Alzheimer's disease by transcriptomic data 55117 3094 84991 533 5549 6881 2257 91369 5601 79026 81603 2549 79006 11224 6299 2872 6141 55274 29117 51560 55737 81873 528 6854 29116 1368 PMC9531511__F2 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis 51199 8408 9474 PMC9532630__F1 Cellular loci involved in the development of brain arteriovenous malformations 3845 673 27302 2022 PMC9532630__F4 Cellular loci involved in the development of brain arteriovenous malformations 4513 7099 4615 3654 PMC9533616__F4 lncRNA PVT1: a novel oncogene in multiple cancers 7422 4904 1956 5820 860 3667 4513 100313892 581 24147 5594 PMC9533616__F6 lncRNA PVT1: a novel oncogene in multiple cancers 7424 9774 648 9839 6935 983 5820 7291 9493 PMC9535406__F5 Role of TGFΒ and autophagy in early crebellum development 4684 1000 1006 1499 4089 4087 4088 PMC9539487__F4 Partners in crime: Proteins implicated in RNA repeat expansion diseases 83939 8662 9100 1939 1994 4076 10146 170506 5901 PMC9549209__F7 Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression 51 1376 948 7038 PMC9549367__F1 Irisin in physiology and pathology 100187907 659 2660 7078 7076 102 114548 PMC9550454__F6 Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach 55872 613 6850 930 5879 4193 4609 PMC9559313__F1 Targeting Glucose Metabolism Enzymes in Cancer Treatment: Current and Emerging Strategies 3099 226 9049 2022 229 355 PMC9561344__F1 Treatment of myocardial interstitial fibrosis in pathological myocardial hypertrophy 387 7046 4088 4087 4089 6347 PMC9562239__F1 Advances in Biomarkers and Endogenous Regulation of Breast Cancer Stem Cells 9334 55366 324 2932 1499 1009 8828 4485 688 6010 6469 5727 2735 6608 51684 57695 5728 896 PMC9563115__F1 Tumor-Associated Neutrophils in Colorectal Cancer Development, Progression and Immunotherapy 9242 3082 3717 3667 7099 6774 PMC9563402__F2 MAPK Signaling Pathway in Oral Squamous Cell Carcinoma: Biological Function and Targeted Therapy 2920 2919 10454 3725 1956 PMC9569062__F5 Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies 594857 920 4827 PMC9569498__F1 O-GlcNAcylation in Renal (Patho)Physiology 8473 5238 6675 10724 PMC9569508__F3 Drosophila as a Model Organism to Study Basic Mechanisms of Longevity 192 3242 11201 6009 27343 PMC9569508__F4 Drosophila as a Model Organism to Study Basic Mechanisms of Longevity 5966 8772 6886 PMC9570317__F1 Advances in Anti-Cancer Activities of Flavonoids in Scutellariae radix: Perspectives on Mechanism 5728 2932 1499 595 1021 1019 6657 1017 894 891 995 PMC9570387__F3 Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance 3785 10235 5594 5595 PMC9572491__F1 Mini Review on Molecules Inducing Caspase-Independent Cell Death: A New Route to Cancer Therapy 581 596 637 355 PMC9574006__F2 Immune checkpoints in cardiovascular disease 3458 6774 840 941 942 3902 5163 2267 PMC9575553__F3 Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer 5469 10499 80853 10765 23028 22992 7018 367 PMC9576517__F2 Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies 10461 29110 95 308 3171 5187 7039 1998 2194 6347 2308 10663 PMC9579409__F5 Hepatic transcriptome profiling according to growth rate reveals acclimation in metabolic regulatory mechanisms to cyclic heat stress in broiler chickens 4099 1431 9118 351 3416 9365 175 PMC9581121__F1 Amino acid metabolism in primary bone sarcomas 26227 3939 29968 5723 27165 445 6470 1719 440 2805 PMC9581404__F3 Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases 1499 999 324 4040 4041 PMC9582432__F2 Microglial autophagy in cerebrovascular diseases 2475 8408 9776 PMC9582522__F3 Brain-gut-muscle axis in human health and energy homeostasis 196 7423 7039 3454 8835 PMC9583506__F2 TRIM family contribute to tumorigenesis, cancer development, and drug resistance 10626 8651 81603 9830 5987 23650 9866 84851 10206 10612 25893 205860 22954 140691 131405 7726 11074 54765 91107 286827 4591 81559 80128 6737 5728 7706 2475 8805 51592 4087 55223 440730 4089 4088 8833 373 56658 960 10155 324 89870 1499 23321 10346 117854 84133 8772 8717 7124 10401 10107 PMC9583547__F3 Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex 2908 6714 2885 1956 3265 5894 5604 PMC9587054__F3 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions 4054 9573 238 5225 9518 5979 389400 7350 155 5443 4852 181 PMC9587054__F4 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions 4040 4041 9885 1499 118 6774 51523 147111 7350 6259 387 PMC9587054__F5 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions 2194 2167 652 23411 7350 5443 4852 181 PMC9589007__F5 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues 50814 39 3157 6307 1718 3156 3930 7108 4598 1595 1506 11330 10654 4047 10682 1717 4597 6713 2224 9453 2222 PMC9589007__F7 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues 3075 3426 10877 966 1191 7448 727 3503 3500 3501 28299 28908 28874 3538 28912 28942 28943 28941 3078 10878 3080 2147 28778 28793 28822 1604 4179 1378 629 1675 81494 729 735 712 713 714 975 731 732 733 715 716 710 717 722 725 4153 5648 10747 1369 720 1361 2220 8547 5627 1370 1506 PMC9589293__F2 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses 11138 4134 347365 4133 5604 51194 23287 57639 7416 23294 7694 683 682 27336 3162 7316 9411 1956 7770 5896 8260 2932 213 3156 55316 4089 142678 54890 10139 10054 83590 5406 367 6319 9994 22861 5408 54828 27122 1081 1350 4094 7559 79822 PMC9589293__F4 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses 114757 3039 3040 2946 6307 8444 5327 5891 8061 966 4087 4088 47 2539 23564 123 9415 6533 338773 1103 PMC9589499__F1 Isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review 9817 2729 1728 6714 581 3553 PMC9592761__F3 Neuroinflammation of microglia polarization in intracerebral hemorrhage and its potential targets for intervention 3696 43 2475 2932 5468 10533 9474 PMC9596393__F4 Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review 2539 5209 3939 PMC9599866__F3 Targeting KRAS in PDAC: A New Way to Cure It? 1956 3845 6790 2475 PMC9603545__F1 Wnt Signaling and Aging of the Gastrointestinal Tract 4041 324 1499 4040 PMC9610703__F5 Current Insights into miRNA and lncRNA Dysregulation in Diabetes: Signal Transduction, Clinical Trials and Biomarker Discovery 2255 2932 2549 2885 5894 10818 3667 8660 3479 2308 4097 581 55384 596 23411 378938 9817 PMC9610910__F2 Protein O-GlcNAcylation in Metabolic Modulation of Skeletal Muscle: A Bright but Long Way to Go 2774 2147 5226 759 7086 PMC9613904__F8 Proteostatic consequences of PKB/Akt-mTORC1 pathway manipulation in muscle 3667 8660 7248 8408 6720 PMC9613996__F5 Hypothesis of how loss of Gamma-secretase function causes ferroptotic stress 4851 7804 9794 6414 51540 2879 22928 PMC9615247__F1 STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy 7039 1950 3082 6774 1636 3578 7124 6352 8651 6346 149233 4313 3627 4170 6935 196 3662 PMC9615310__F1 Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis 51380 875 635 4548 79587 4357 6469 58472 7263 PMC9693393__F1 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve 5728 7248 7249 3815 5163 4485 60485 7462 PMC9693393__F2 DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve 545 472 268 2475 PMC9812393__F8 SKN-1A/Nrf1 lipid homeostasis response 128486 5091 5346 PMC100005__F11 Formation of TrkA–src-aPKC complexes 10818 6714 7189 PMC10037167__F1 Myostatin silencing inhibits podocyte apoptosis in membranous nephropathy through Smad3/PKA/NOX4 signaling pathway 2660 4088 50507 PMC10040131__F7 PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer 84295 2186 7422 4015 51129 10551 358 PMC10040548__F5 Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis 26227 4118 11113 23475 10135 PMC10040548__F6 Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis 26227 5723 4548 PMC10041467__F1 Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer’s Disease 1593 1581 23600 570 PMC1064894__F3 Toll-like receptor (TLR) signaling pathways 7099 51284 54106 7098 7100 7096 7097 114609 4615 7189 3661 PMC1083688__F2 Curbing the nuclear activities of Beta-catenin 474168 51701 847 10940 11201 6908 PMC1134761__F4 Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit 10276 762 324 PMC1143566__F2 A schematic diagram for the hedgehog (HH) signaling pathway 50846 3549 6469 6608 51684 PMC120783__F7 GPI biosynthetic pathways in T 4023 450095 5340 95 51083 PMC126171__F5 Different telomere damage signaling pathways in human and mouse cells 1021 1019 1017 PMC1280267__F7 Model schema for the phosphorylation of CRMP-2 by Rho kinase, Cdk5, and GSK-3B 10371 2534 6010 2932 1020 8650 PMC1297683__F3 Final network resulting from applications of our integration method to the 18 types of evidence for yeast galactose utilization and a set of network analysis tools 2592 51056 7851 100187761 PMC1327682__F3 Schematic overview of the Saccharomyces cerevisiae central carbon metabolism 2820 2023 2026 4118 11113 100653366 718 48 PMC1356334__F7 Alignment of sequences adjacent to Y200 for human TRPV1–4 7442 6714 4803 PMC1359062__F1 Ciliated cell differentiation into goblet cells requires 2 signals 1950 7039 1956 6778 PMC1361361__F7 Shp-1 mediates the anti-proliferative activity of TIMP-2 in human microvascular endothelial cells 7077 2260 1017 1019 8434 PMC1369209__F3 Models for ECT-2 activation and its role in activating the EGFR/RAS/MAPK pathway 1950 1956 1894 2885 PMC139817__F7 Regulatory interactions between SRF and TCF 6010 51083 6717 6722 PMC1409799__F4 MAPK signaling pathways 4201 4976 5979 6402 11043 PMC1415320__F6 The proposed TGFB1 signaling mechanism that promotes EMT 999 1499 2932 4087 4088 4089 PMC1449579__F1 F igure 1.— 118027463 56852 5111 PMC1449579__F5 F igure 5.— 118027463 56852 5111 5428 PMC1456973__F6 Aspartate and aspartate transport in the pathway of prostate citrate production 1431 4118 11113 PMC1479092__F1 The mitochondrial generated ROS-mediated activation of the p38 MAPK stress response pathway 1386 466 2002 7018 3726 3725 PMC1483059__F10 Peculiar structure of the juxtanuclear actin network 387 5879 6714 998 PMC150381__F2 Interplay of the major genetic alteration in pancreatic carcinoma with the cell cycle 595 1021 1019 4089 PMC1559555__F1 GSH metabolic pathway 2880 2936 2876 2944 2949 2937 2729 2730 4899 PMC1609340__F1 Outline of the TLR signalling pathway 7098 7099 7097 54106 114609 4615 3661 3654 29110 23118 10010 3665 7124 PMC1622797__F5 Proposed molecular model of dietary omega-3 fatty acid interference with IL-1 signaling pathways leading to COX-2 induction in EC 2815 23118 4513 54472 PMC1682015__F2 Example pathway structures based on Z-scores of reactions, which demonstrate the metabolomic response of the selected reactions in the reported case studies, namely, the effect of an altered redox metabolism and aerobic/anaerobic growth 2571 7054 11113 5105 PMC1682017__F4 Effect of increased HER2 expression on phosphorylation sites within the EGFR signaling network 1950 3273 2060 847 5829 59330 PMC1682017__F5 Effect of HRG stimulation versus EGF stimulation in high HER2-expressing cells 1950 3273 6714 847 PMC1779520__F3 Signaling pathways activated by serum and GF treatments 5800 2885 26207 10253 81848 6714 7532 1847 1848 6774 3726 4616 8835 9021 9655 PMC1783401__F6 Integration of Runx1 and the BMP signaling pathway into the SCL transcriptional network 652 2624 2078 4086 4091 861 PMC1839882__F9 Schematic illustration of the principal signaling pathways that are affected by sodium arsenite (As) treatment 673 1956 1386 3717 6774 331 355 PMC1847380__F14 Signaling pathways leading to pseudohyphal growth 998 59272 375757 PMC1850774__F5 Convergence of signaling pathways 2534 2885 5728 3611 572 1499 PMC1852238__F1 Role of the glutathione pathway and ABC-transporter family in drug elimination and defense from ROS-mediated oxidative stress 9429 4363 5243 2876 PMC187486__F8 Effects of Cdk4 disruption on the pathways controlling senescence and transformation 4193 1019 1017 PMC1878539__F1 Unchecked thrombin is bad news for troubled arteries 7018 7035 324 PMC1895816__F2 Identification of a Bcr-Abl kinase signature 23607 613 7408 2932 1859 204851 1018 PMC1896004__F4 Signaling pathways downstream of the Toll/TLRs 7189 51295 8195 4615 PMC1899878__F1 Regulation of dimorphism in C 10487 27010 1889 3084 PMC1899924__F8 Signaling pathways activated by mitogenic concentrations of TNFA and roles of furin, MT1-MMP, and MMP2 in the activation of the nSMase in mesenchymal cells 7124 4313 5045 PMC1914109__F8 The p110D → RhoA → PTEN signalling pathway described in the text 6714 718 5728 PMC20092__F5 A model for the v-Crk-mediated signaling pathway 2885 1398 3725 PMC2014644__F2 PGE2-EP receptor signaling pathways 1385 1958 1956 2932 1499 PMC20445__F6 Schematic diagram showing steps in the signaling pathway by which P 3929 1080 6714 5539 PMC2063513__F6 Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling 3694 610 3912 2050 8434 4318 PMC2148057__F8 Proteosomal degradation pathway 10197 4734 23198 3105 3135 3137 PMC2151841__F4 Signal transduction pathway in the UPR 22926 7186 1998 468 PMC2151969__F4 Genes up-regulated and down-regulated by FGF-2 in IGF-I signaling pathway 3479 3480 5076 238 23379 PMC2151969__F5 Genes up-regulated and down-regulated by FGF-2 in TGFB signaling pathway 4838 4087 3196 5308 145258 3224 2353 8928 7421 3725 PMC2169177__F10 Schematic view of Ras- and calcineurin-dependent pathways in T cells 7535 5924 7409 5879 10125 50964 969 3558 PMC2195911__F10 A molecular mechanism whereby cAMP inhibits T cell function 920 3932 1445 PMC2198843__F1 Adhesion regulation of nucleocytoplasmic trafficking of signaling molecules 3611 8573 847 324 51176 2002 PMC2213224__F8 Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion 6714 2885 1399 1398 5879 3265 5894 PMC2219351__F1 Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients 1956 8527 5728 4515 2932 1499 999 6418 PMC2220082__F2 Rosilitazone stimulates NSCLC proliferation by affecting the Akt/mTOR pathway through PPARGamma-dependent and PPARGamma-independent mechanisms 5728 7249 2475 PMC2238789__F4 Neuronal pathway containing proteins found in Lewy bodies 4864 6647 1113 4131 6855 730 4747 4133 54205 4744 793 7054 6622 3315 1191 4792 PMC2238789__F5 Interactions of known PD genes (marked yellow) with the priority genes of this study 6855 7070 6623 6622 7054 5300 2019 6620 PMC2254980__F4 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice 355 79071 7038 PMC2259254__F2 Balance between muscle hypertrophy and atrophy depends on whether protein synthesis is more active than degradation or vice versa 3479 2475 2932 PMC2269037__F3 PI3K/AKT signaling pathway activated by 3Alpha-diol 5728 572 7249 6009 1977 PMC2270852__F5 Schematic of signaling pathways in PDAC 1956 6774 5728 2475 4089 PMC2275788__F2 Mapping Genetically Compensatory Pathways from Synthetic Lethal Interactions in Yeast 8819 79577 6880 403 699 9184 5888 400 51699 5893 738 10111 56852 PMC2276649__F8 GSK-3B Targets Cdc25A for Ubiquitin-Mediated Proteolysis and GSK-3B Inactivation Correlates with Cdc25A Overproduction in Human Cancers 545 472 993 2932 PMC2277398__F1 MAP kinase pathway analysis of the meta-modes 1610 4351 5062 5058 100187907 4149 10783 10454 23118 7189 51701 PMC2290973__F2 Pathway Studio diagram of common regulators of differentially expressed genes 5340 4684 3383 2149 3791 5880 998 6295 7157 6654 6773 6886 2033 4088 4208 PMC2292640__F1 SARS CORONAVIRUS AND INNATE IMMUNITY 59272 3455 3454 23586 7297 57506 7098 7187 10379 3661 6772 6773 PMC2315681__F8 Leptin's roles in the endocardial cushion 1003 4323 4313 PMC2342468__F1 Cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice 5350 6262 3371 PMC2346559__F1 An Allosteric Mechanism for Switching between Parallel Tracks in Mammalian Sulfur Metabolism 23269 27232 635 4524 4397 875 PMC2361340__F5 Differential targets of copy number-induced expression changes in key biochemical pathways between SCLC and NSCLC 3146 1956 1826 5601 7074 3845 10808 3621 4216 4089 3925 3726 3398 1029 1870 51701 6664 1019 9735 1017 6925 PMC2390572__F9 MCF10A Pathway 1 affected by TFIIS knockdown 9052 3437 25805 3600 7091 8886 1521 26257 3151 4609 5931 64065 6760 7157 23645 30000 5926 56654 5429 4782 PMC2394714__F10 TGFB1-induced PAI-1 expression in VSMC 1956 4088 4089 4087 387 PMC2395193__F3 Gene networks identified in both recEbo-VP35/WT- and recEbo-VP35/R312A-infected cells compared to mock-infected and irradiated controls 10560 10010 7157 2353 6955 133418 11198 5093 6133 5702 1029 11186 4254 2023 5230 1495 4071 26502 PMC2410042__F2 Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival 1435 1436 3653 8819 7035 6494 23076 23476 2146 4830 4692 221476 10628 7046 7040 5728 7049 7043 PMC2423294__F8 The PKD1/class II HDAC/MEF2 signaling pathway in skeletal muscle 5311 5312 5310 PMC2435243__F9 Several signaling pathways work together in the TGFB1-induced expression of CCN2/CTGF in primary human gingival fibroblasts 4018 998 6010 718 4088 PMC2475726__F10 F igure 10.— 338340 51455 5893 PMC2480606__F2 NFKB pathway in skeletal muscles 581 602 595 7528 PMC2483283__F5 Leucine degradation pathway in mitochondria 586 587 3712 4163 PMC2490815__F3 Regulation of NFKB pathway by PPAR agonists in CNS diseases 3929 929 958 7099 54106 4615 7189 PMC2491599__F3 Wnt signaling pathwhay in cervical cancer 51701 7976 847 324 404685 9475 PMC2516358__F7 Time ordered sequential events control cellular decision of migration 54206 10170 3082 5328 9590 1958 5743 2353 PMC2517590__F2 Schematic overview of the integrin signaling 6714 1445 5879 998 387 1399 PMC2519092__F2 Cellular responses after six hours exposure to L 3105 3107 387 1040 65057 7200 PMC2529314__F7 Interactions of KEGG pathways for differentially expressed genes in different stages of PAD 351 613 2241 PMC2533092__F1 Metabolic pathways for the synthesis of phospholipids and neutral lipid classes in S 84706 1040 5091 PMC2533280__F1 Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood 3170 9350 8646 3211 55897 PMC2546860__F2 Glycerol biosynthesis and other major pathways contributing to cytosolic NAD+/NADH balance in S 54820 7167 2819 PMC2572865__F1 Hematopoietic niche and bone meet 5741 657 658 5745 22943 182 4041 1499 PMC2574011__F1 Store-operated Ca2+ entry in T cells 84876 3932 27040 50943 PMC2575803__F1 Most prominently involved biological pathways in OSCC 7297 6772 6773 8554 2813 1384 2475 5292 PMC2577137__F1 Cross talk between PKA, PI3K/AKT and WNT/CTNNB1 intracellular signaling pathways 3479 2492 3480 5728 1499 2308 2475 PMC2577687__F1 Metabolic scheme 5091 11113 4118 PMC2578840__F8 Proposed signaling pathway 4087 4088 4089 PMC2581798__F3 Information flow through the JNK network 1017 995 1019 3652 3725 2353 2241 5979 23049 5163 65018 PMC2583327__F10 Transcriptional and Translational Regulation of Transforming Growth FactorB Production in Response to Apoptotic Cells 387 1977 2475 PMC2586079__F1 COMPLEMENT ACTIVATION FRAGMENT Bb IN EARLY PREGNANCY AND SPONTANEOUS PRETERM BIRTH 716 715 717 718 727 PMC2592774__F1 TLR signalling pathways 4118 3654 6850 7189 29110 7187 3661 7124 4615 4513 PMC2593012__F2 Gene expression data mapped on the Mus musculus fatty acid synthesis pathway 31 100187761 95 2194 PMC2593123__F1 A simplified schematic of the core left-right signaling pathway in the e8.5 (6 somite) mouse embryo 10637 7044 4838 PMC2603427__F5 Hierarchical layout of the EGFR1 pathway downloaded from the HPRD pathway database 207 5894 2005 6714 10044 858 4087 4609 842 3725 5359 868 28964 5782 6004 2060 6774 634 3717 5338 5335 2885 1398 6777 10188 5579 5578 5590 5582 1500 6456 5337 PMC2603427__F6 Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database 842 840 2534 5587 695 3550 2185 84433 7006 100124696 6850 933 3059 867 974 5595 26469 6195 5336 29760 118788 6464 1385 1019 1017 1021 5599 1432 5296 5925 5530 5534 207 5594 6198 4772 4775 4773 2002 2932 6194 604 673 2931 PMC2607114__F1 TFPI anti-coagulant and anti-inflammatory activities 7035 7018 831 4067 6714 PMC2615542__F2 Luteolin, a flavonoid with potentials for cancer prevention and therapy 8772 637 5970 581 331 PMC2615558__F4 Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus 811 467 5327 6688 2200 2353 6575 5329 23429 1440 3958 5933 7078 841 5396 355 842 658 961 PMC2630471__F5 DAF-2 Insulin-like Signaling Pathway Independently Regulates Aging and Immunity 3630 5163 5728 207 208 6446 PMC2631022__F1 ECM-receptor interaction pathway enriched by human switch-like genes 960 7450 1101 948 961 PMC2634101__F1 Model summarizing some of the pathways described in this review leading to chemotaxis and cell motility 5728 998 2638 PMC2634968__F5 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling 7098 5879 7409 PMC2634968__F6 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling 3654 92610 84962 PMC2637179__F2 Role of IRS-1 in insulin and IGF-1 signaling 3479 2885 3667 9820 2475 PMC2637474__F7 Hypothetical pathway involved in general cerebellum-mediated motor learning 1431 2638 1634 PMC2643928__F1 Activation of the transcription factors IRF3 and NFKB in response to infection with a single-stranded RNA virus 57506 8772 7187 10010 3661 843 841 PMC2643977__F4 Proposed integrated model for local water transport inhibition by activation of P2Y2 and adenosine A1 receptors (A1R) in inner medullary collecting duct principal cell 359 84890 367 361 551 360 PMC2650010__F3 Akt-dependent and independent mechanisms of mTOR regulation in cancer 7248 7249 6009 2475 64223 PMC2654975__F1 Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease 102 6868 51107 83464 28514 23385 5663 10683 54567 5664 55851 3902 9612 9794 84441 55534 3280 54626 388585 23462 23493 182 3714 26508 8650 4440 124540 1840 113878 55294 5045 3955 5986 1759 1785 26052 6477 57534 142678 140825 23509 23275 161 55502 83737 4734 23013 PMC2657106__F1 Activation of the G2/M checkpoint after DNA damage 545 472 5347 324 7465 983 4661 PMC2657476__F1 ErbB Receptors in the Biology and Pathology of the Aerodigestive Tract 1956 2549 2885 6774 5163 6714 572 596 PMC2660380__F3 Lysophosphatidic Acid Signaling in Airway Epithelium: Role in Airway Inflammation and Remodeling 1839 4018 1956 4067 PMC2661888__F3 Hypergraph representation of the Boolean model for yeast glucose repression 51083 2592 375307 5105 PMC2662467__F6 Cell proliferation and apoptosis 5728 4194 1956 5156 4193 5925 2064 1019 1021 4763 PMC2663984__F5 Expanded canonical Wnt/GSK3 signaling pathway 4041 4040 324 1499 PMC2665727__F5 Ty retrotransposition cycle 5893 51163 167227 27258 25804 51690 57819 11157 23658 27257 54464 PMC2667769__F5 Defective respiration of Δisc1 in the post-diauxic phase 157739 11113 4513 4508 PMC2668371__F9 The proposed model 6009 2475 1977 PMC2670002__F7 Pathway in colorectal cancer (CRC) progression from normal colon to late-stage cancer 2041 1969 2047 2048 2050 PMC2671025__F6 Role of adiponectin in human skeletal muscle bioenergetics 51094 79602 4208 6648 PMC2671376__F7 Signaling in the PI3K/Akt pathway and deregulations detected in GRMD skeletal muscle 5728 2475 3416 PMC2671566__F7 Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor 27040 4038 4593 285489 PMC2672935__F2 Regulated molecules in canonical signalling pathways identified by IPA 5728 3586 7097 8772 7186 387 6010 6772 637 11140 811 6892 1026 6502 2810 PMC2674579__F1 GST-MDA-7 causes PERK-dependent vacuolization and JNK pathway activation in transformed cells that leads to cell death 637 581 572 PMC2676714__F4 Pathways analysis on the set of genes contained in the SNP component 5289 5595 7124 5594 4190 5243 348 PMC2678983__F4 IFN-gamma signaling pathway 2176 1610 6772 4092 1386 10379 PMC2683382__F2 Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites 85480 64806 90865 6761 55540 7006 100124696 7189 4615 51135 6774 PMC2683667__F4 Induction of IFN-signaling pathways in HCV-infected uPA-SCID mice (A) and patients (B) 3459 3460 3716 7297 3717 6773 6772 10379 2155 3665 3661 PMC2684867__F1 VHL Loss of Function and Its Impact on Oncogenic Signaling Networks in Clear Cell Renal Cell Carcinoma 3082 999 4040 4041 PMC2686112__F1 VHL gene complex targets hypoxia-inducible factors (HIF) for ubiquitin-mediated degradation 7428 8453 7039 2147 1956 PMC2688747__F4 Fgf and Sdf-1 Pathways Interact during Zebrafish Fin Regeneration 80326 81029 2260 PMC2689781__F7 Grade-dependent Proteomics Characterization of Kidney Cancer 2821 2203 5214 226 229 230 2023 2026 5106 8801 1738 126 PMC2690586__F1 Maintenance of the G1/S DNA damage checkpoint in the presence and absence of Cdk2 1017 983 472 545 PMC2692402__F1 Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis 84803 150763 137964 4018 10554 10555 56895 55326 56894 5091 8694 84649 PMC2692422__F7 IL-1Beta-induced upregulation of RGS4 expression in colonic SMCs via canonical IKK2/IKBA/NFKB signaling is differentially modulated by the MAPK and PI3K/Akt/GSK3B pathways 3553 2932 5999 PMC2695822__F9 Display of genes with high expression in IVF embryos 7523 8178 5621 7157 25983 PMC2696125__F2 Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease 572 581 637 638 4513 PMC2696319__F1 Sites of mutation which can result in activation of the Raf>MEK>ERK pathway 3815 4067 6714 PMC2696566__F2 Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy 142 545 472 995 PMC2697172__F8 Sub-network associated with the Wnt signaling pathway 6418 2098 25942 6873 6908 5662 5091 6883 6874 5548 23013 4602 90525 23152 51684 100188011 6608 6010 8650 7536 5817 7272 PMC2699904__F7 Inter-relationships of genes associated with apoptosis differentially expressed in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice 1191 2194 4170 10892 330 4139 841 329 596 597 599 4613 2099 6418 3725 7494 6872 PMC2705999__F3 Castration-Adapted Prostate Cancer: Targeting Androgen Metabolic Pathways in Recurrent Disease 412 1583 8644 1586 1645 7366 7367 9420 PMC2712453__F3 S-phase signaling pathways inferred with different heuristics 8318 84188 990 1036 PMC2713013__F3 MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES 51284 51311 7096 54106 7097 7099 81622 7098 948 929 4615 4118 29110 7187 7189 23118 10454 3663 3665 3661 7124 3654 PMC2713013__F7 MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES 4615 51135 3654 7189 3553 PMC2713330__F1 Innate Immunity in the Lungs 7097 7096 10333 7099 7098 929 7100 54106 10454 23118 29110 7189 3661 3553 4615 3654 114609 51135 PMC2718437__F2a Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B 7040 4052 2022 7057 3624 10468 652 9241 6696 7048 860 25805 864 4086 4091 4090 4093 4088 4087 4092 4089 51176 3716 6774 5601 3725 5594 1387 6497 2353 PMC2721360__F2 Colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition 5621 3091 4780 207 3486 2274 5914 1499 1519 1509 4089 11197 140805 3691 8312 324 4130 878 7088 4609 PMC2721397__F2 Key pathways in hepatocarcinogenesis and molecularly targeted agents currently under investigation in treatment of advanced HCC 3082 1950 2475 PMC2721684__F1 Signaling pathways triggered by TLR3, TLR4 and TLR1–TLR2 7099 7098 114609 4615 3656 3654 51135 7189 7187 29110 3661 PMC2724047__F5 Major cell signaling pathways activated by bile acids in hepatocytes 2264 2064 2065 998 3265 5163 208 PMC2726954__F2 Quest for genetic determinants of human longevity: challenges and insights 3479 3480 5728 5163 207 6446 208 PMC2727709__F1 Multiple previously established signaling cascades in activated mast cells with quantitative proteomic data from MCP5 cells represented as heatmap bars beside individual proteins 3562 695 6850 2534 6714 4067 2885 7297 9846 5091 PMC2729932__F2 ES-EB system has made possible the identification of multipotent progenitors for both hemato-vascular and cardio-vascular derivatives 1482 2626 2624 3670 PMC2735462__F3 Ubiquitin in NFKB Signaling 8717 1540 57506 10010 3661 PMC2742584__F7 Interaction networks of As sensitivity in yeast 29935 777642 5983 5985 5982 4361 5984 11169 10111 PMC2742684__F1 Key signaling pathways between amino acids, inflammatory cytokines, and tumor-specific factors gr1Amino acids stimulate muscle protein synthesis through the mTOR pathway 2475 1998 4654 1977 PMC2743272__F1 Mechanisms underlying the pleiotropic effects of statins in stroke 650 387 3704 998 5879 PMC2744356__F1 Toll-like receptors in skin infectious and inflammatory diseases 7099 7097 10333 7100 4615 51311 51284 7098 54106 3654 7189 29110 3661 PMC2746202__F1 Pathway from PI3K to TOR 5728 7249 6009 PMC2749270__F1 Sphingosine-1-phosphate synthesis and functions in mast cells 2534 4067 8877 56848 5226 PMC2750148__F2 NFKB signal transduction 4615 7189 7316 23118 PMC2751986__F7 Rev-erbA/PGC-1A pathway regulating heme homeostasis 211 4899 6095 9575 406 PMC2752535__F4 Common features of host-Flaviviridae interactions 57620 7329 7150 4091 2972 999 1008 1457 1147 6788 5894 2549 5879 1535 2324 7535 6774 11030 7003 7707 10413 7005 22884 8446 10134 10239 4502 10370 145258 30000 9507 1994 6949 7020 3170 6935 5518 1154 55223 10114 4140 4087 9891 3303 64750 6498 81788 7311 53904 8767 55660 29110 84220 27035 586 57154 168544 3337 593 8237 3777 9020 8295 8089 23054 1315 10607 51085 3297 PMC2754046__F1 Hypothetical schematic of a DAergic synapse 7054 1621 1312 PMC2756058__F1 Pathway of cellular processing of cobalamin (OH-cbl) and location of main enzyme defects in the pathway leading to methylmalonic acidemias and cobalamin metabolic disorders 166785 84693 326625 867 27249 25974 PMC2757120__F1 Canonical PI3K signaling pathway 5728 3667 5163 7248 7249 2932 6009 4609 3725 PMC2757648__F3 Interferon response genes are coordinately upregulated relative to the rs17445836 allele of IRF8 3454 1147 4084 4600 64135 4088 313 3665 3663 54106 3624 8477 2735 11027 6280 8651 6279 3433 3434 4688 1436 7099 177 5300 3440 6688 1520 4034 5371 PMC2761008__F2 Minimum spanning tree of the network associated with cancer pathway genes 6160 11343 5565 5373 2752 3838 4502 1512 4804 6659 8301 596 1509 5111 1643 2690 3717 1508 5970 6197 472 6004 5934 8525 6908 8317 1839 5997 10856 6648 8871 7042 6622 1017 10983 351 4087 7046 9134 2885 7320 4638 3400 72 6498 23764 4897 56993 4208 10982 PMC2770887__F1 ER stress-induced signaling pathways that mediate autophagy 1939 9140 2475 9474 PMC2771724__F3 Dopamine Receptor Signaling: Genes differentially expressed in the NAC of LE vs 1312 4129 1812 1813 10846 51422 5507 PMC2776679__F7 Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R 3479 3480 8660 5728 1958 28996 PMC2780394__F7 The signaling network of differentially expressed proteins 7033 572 84254 331 998 5578 1111 1019 1017 5970 1499 8626 PMC2781439__F7 Speculative model depicting mono-ubiquitination-dependent and independent functions of the FA-BRCA pathway in DNA replication-associated repair processes 2177 5111 545 3398 29089 7398 56852 51455 PMC2783518__F1 Wnt signaling and senescence: a tug of war in early neoplasia? 1499 4286 4040 4041 PMC2786169__F4 Topology of leukemia-related BCR-ABL pathway 613 1399 2885 3717 6776 4609 6772 572 PMC2790404__F2 Viral infection elicits a variety of antiviral cellular responses 7098 3661 338376 PMC2796989__F1 Interleukin (IL)-13/transforming growth factor (TGF)B signalling pathways 3597 3598 4092 PMC2799380__F6 Connective tissue associated signalling network common to various cardiac hypertrophy animal models and human cardiac disease 1278 1277 7373 1281 7076 54829 3488 2335 1431 2199 7077 4060 5054 351 5270 4147 476 4087 4088 9180 6541 4089 1956 2318 23213 687 PMC2799977__F2 TLR signaling upon intrinsic cellular defenses 7096 10333 7097 51284 51311 7098 54106 3656 22906 7189 29110 7187 4615 3663 3661 3553 PMC2800820__F1 Multiple pro-inflammatory mediators in the tumor microenvironment increase the accumulation of MDS cells and enhance their immunosuppressive activity 4513 3553 718 PMC2801237__F5 Proposed revised model of mammalian DNA damage response 472 545 10111 9656 4361 9025 672 3014 PMC2805044__F1 The Akt/mTOR pathway in tobacco-carcinogen induced lung tumorigenesis 3845 5266 5728 572 7248 7249 6009 PMC2805685__F11 Reconstruct part of KEGG pathway by our method 5163 596 1956 84920 6772 7528 1386 405 3298 861 1871 PMC2806300__F8 Reversal of EMT induced by TGFB1 387 4089 4087 4088 6935 9839 PMC2806370__F2 Cell cycle pathway gene expression 7040 650 7042 7048 8243 7049 2033 699 9700 4193 545 5591 9184 4088 2932 472 219972 4089 6500 10744 6502 9232 5925 7157 701 1111 11200 1027 1647 7532 991 5111 993 995 595 896 9134 8900 891 890 894 898 9133 902 1019 1017 85417 1021 5347 990 999 25 7465 9088 5933 8556 8317 11138 64682 10393 10297 8881 51529 29945 51434 996 8697 140739 PMC2808051__F1 Summary of the insulin/IGF signaling pathway, using the terminology for mammalian systems 5163 472 5728 8473 2475 581 PMC2810358__F2 Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas 5982 5985 9126 8243 2956 4173 4171 2237 4436 91754 4174 11198 84515 4678 6601 23524 595 23224 10051 9918 PMC2813229__F4 Pathway analysis result showing 18 differentially expressed proteins following 50% PH can be sorted into the c-myc pathway 34 4722 5371 5629 PMC2815132__F1 Dopamine Synthesis Pathway: Dopamine’s synthesis pathway begins with the amino acid tyrosine and is regulated by the activity of tyrosine hydroyxylase 5409 7054 1621 1312 PMC2816026__F7 Met signal transduction exploited by InlB from L 2534 867 2011 91754 PMC2818158__F1 Inflammation at a molecular level: a simplified scheme 7098 7099 7124 6955 4118 3661 PMC2818238__F1 Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms 5091 847 762 PMC2821476__F3 TNFA induced signaling 8717 7186 8772 83737 PMC2822054__F1 How the PI3K-AKT and MEK-ERK pathways regulate apoptosis in EGFR driven cancers 5163 2885 4193 4609 595 1956 2065 PMC2822975__F1 Asbestos has pleiotropic effects on cell signaling pathways 5728 1956 7249 2475 8717 PMC2828057__F1 Genetic factors influencing cytarabine therapy 978 22978 1633 1635 6240 6241 PMC2829061__F7 Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair 118027463 983 5888 147912 PMC2838081__F10 Molecular pathways regulated by C/EBPB during E-induced proliferation of uterine epithelial cells 56852 545 472 1871 1017 PMC2842492__F2 Transcripts regulating the mammalian cell cycle are up-regulated in the proliferative-phase endometrial epithelium 545 4193 699 472 9184 4357 4088 4089 6502 991 5111 993 1021 1019 1017 983 324 4661 8317 4999 23595 PMC2843459__F11 Schematic diagram illustrating the proposed signaling pathway involved in LTA-induced cPLA2/COX-2–dependent airway inflammation 4049 4615 5879 7097 PMC2843693__F2 Molecular Origins of Cancer 324 7157 3845 4089 5290 7048 581 673 5728 1499 4292 1956 PMC2844640__F1 Role of Radiation-induced TGF-beta Signaling in Cancer Therapy 7046 4089 4088 4087 4092 PMC2846630__F1 Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1 3479 3667 253260 5728 51083 64798 7248 2597 6009 PMC2848014__F8 Proteomics Reveals Novel Oxidative and Glycolytic Mechanisms in Type 1 Diabetic Patients' Skin Which Are Normalized by Kidney-Pancreas Transplantation 5465 23440 3315 PMC2850388__F7 Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair 1896 6469 1499 51176 22943 27123 27121 6657 54345 PMC2853417__F5 Differentially expressed genes in the TGFB signaling pathway 650 4838 7030 7421 860 864 145258 3196 PMC2854285__F1 mTOR and cancer: many loops in one pathway 5728 5163 7249 7248 6009 64798 572 PMC2858157__F6 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration 672 56852 10915 126626 4175 11200 7593 8772 6118 11078 10782 9447 7296 3725 7187 171392 10309 11214 10818 6550 PMC2858157__F8 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration 1869 1870 284565 990 890 836 5558 1663 8841 5905 6790 2012 63967 8881 PMC2858157__F9 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration 5111 1869 2012 8841 51514 990 1870 63967 10049 8881 51343 890 2056 5558 PMC2858523__F1 Schematic diagram showing the RAS-MAPK signal transduction pathway and affected disease genes in disorders of the neurocardiofacialcutaneous syndrome family 3265 1431 3845 2885 6654 5894 673 161742 8036 PMC2858611__F3 Depiction of the “Reelin signalling in neurons” pathway generated by Ingenuity 348 7436 3688 351 9479 322 1399 3055 1600 2534 4069 2932 207 4137 23229 PMC2860309__F1 EDA signaling 5045 51176 10913 1896 5970 27121 22943 6469 8174 4050 23118 128178 7189 PMC2860555__F1 Endosomal and cytoplasmic pathways for virus recognition and IFN production 7098 51311 51284 57506 4615 7189 51135 3654 29110 3665 3661 PMC2860937__F1 Caveat mTOR: aberrant signaling disrupts corticogenesis 5728 5163 6009 2475 9024 84446 1977 PMC2861325__F9 An Ingenuity pathway analysis containing about half of the genes in subfactor 8 of Myc factor 6 60468 10527 84790 7203 408 10236 409 5478 55379 7534 5708 1981 6129 3313 9570 5629 2597 7416 375 4609 5879 7283 5717 8317 2739 27338 55872 5695 6790 29127 7157 9212 699 701 5688 1111 6647 4751 5684 7272 10963 PMC2861828__F1 Signaling pathway that connects store-operated Ca2+ entry with NFAT-dependent gene transcription in T cells 759 4827 90550 84876 27040 3702 PMC2862089__F1 Signal transduction pathways and crosstalk activated by insulin/IGF-1 receptor and GPCR systems 3667 8660 7249 7248 5163 9610 253260 6009 2475 PMC2862795__F1 Multi-component nature of TGFB and Wnt Pathways 2932 4092 4089 1499 PMC2865177__F1 ER stress-induced apoptotic pathways 581 7186 83939 468 596 30001 PMC2865336__F7 Role of Rad9A in the G2 decatenation checkpoint 545 7486 5883 672 11073 891 PMC2866141__F4 Molecular Basis of Pulmonary Alveolar Proteinosis 929 114609 4118 3717 4615 3654 7189 54472 PMC2868782__F3 Comparison of protein and gene expression studies 6294 5447 2475 PMC2872012__F4 Functional genetic network as defined by the bioPIXIE tool (Myers et al 123169 6944 23168 8819 57589 51028 23355 57617 51699 PMC2872012__F5 Detailed representation of the interactions between the components of the gene network 51699 55737 6944 PMC2874322__F5 An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 2312 5650 9076 85480 7908 64127 10392 929 1672 3660 6706 6704 6698 6699 6701 6700 6705 3713 6707 PMC2878924__F5 DNA damage checkpoint pathways 3364 4361 5884 10111 84126 545 472 9656 11073 672 8318 5810 PMC2879143__F4 Signaling cluster and integrin signaling 1956 7124 100187761 6497 4691 5972 PMC2879563__F1 Subdivision of the estrogen metabolic pathway 10720 1312 10 2950 PMC2880289__F6 Complex deregulation of the Neuregulin/ERBB2 signaling pathway 6476 2069 2886 5295 3326 54206 2885 5728 6655 5163 5584 3265 5894 208 572 5604 2475 1027 6194 6198 4609 2002 2064 2066 PMC2883337__F1 Chromaffin cell genes involved in catecholamine biosynthesis, storage, secretion and degradation 5805 6697 5860 7054 1644 1113 1114 7857 4852 6843 5409 4128 4129 1312 PMC2884012__F1 Tuberous Sclerosis Complex: A Brave New World? 5728 6009 7248 7249 PMC2884164__F5 Significant signaling pathway networks mined from pituitary adenoma comparative dataset 4610 5481 7052 9365 PMC2886330__F1 Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells 1956 5728 2475 PMC2887084__F1 New Strategies in Head and Neck Cancer: epidermal growth factor receptor inhibition in head and neck cancer 1950 7039 3265 1839 2885 6714 5728 2475 595 PMC2889025__F1 Response of p53 to DSBs generated by ionizing radiation 545 472 4193 993 581 1017 8318 PMC2891025__F6 Deep mRNA Sequencing for In Vivo Functional Analysis of Cardiac Transcriptional Regulators: Application to GAq 4879 4878 9172 4208 845 137735 27063 58 4892 3913 126393 55740 10391 3680 7414 1869 3275 1306 10970 7832 1956 4773 1827 PMC2891151__F1 TGFB ligands signal through the type I and type II TGFB receptors 4838 4091 64750 4609 1021 1019 1017 PMC2891586__F3 Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks 1855 3955 1856 4242 5986 1857 8650 1840 9253 113878 196403 28514 10683 151636 23220 54567 3280 388585 55851 11317 5663 23385 5664 182 3714 83737 9794 2033 4089 4790 2932 PMC2892459__F4 Snapshots from the integrated macrophage pathway diagram 7297 3454 3456 6478 868 5707 5708 5710 5713 5717 5719 378884 9320 5700 3113 3111 1432 3122 3099 8575 8837 355 7124 5548 PMC2894618__F2 Lineage relationships of cells originating in the otocyst 6657 2260 26281 2737 6469 474 5629 2253 2261 23493 PMC2896712__F2 Metabolic pathway map constructed using the E-Cell RBC model 4256 283871 64851 PMC2896911__F8 Regulatory network that links the activities of an ensemble of transcriptional regulators, signaling components and survival factors in developing B cells into a common pathway 51564 973 5079 10664 974 640 930 1870 53335 7852 2078 7441 29760 5451 29802 2146 5896 2113 51176 3662 3399 6850 3394 5728 6932 2308 604 3398 6659 860 4851 6774 864 3204 23410 2625 1051 596 1958 2114 PMC2897739__F1 Recent advances in the genetics of systemic lupus erythematosus 3458 9474 7297 3716 10320 4067 3665 3663 6772 10318 7189 7128 3394 7332 7292 4688 2113 3595 3684 639 54106 2212 3454 3455 PMC2903563__F7 Glucose metabolic pathway response 5236 2571 2820 157739 5230 2026 2023 5131 134359 PMC2904042__F2 Concurrent deregulation of the top five canonical pathways in retinoblastoma (RB) tumors 2177 472 672 4361 PMC2905627__F7 Schematic diagram demonstrates intracellular signaling events in the Ras/ERK1/2 pathway as well as the upstream and downstream cascades activated by GDNF in the C18-4 cells 2668 2674 5979 2885 466 1017 PMC2907250__F1 The three top ranked pathways in this study.‘Syndecan-1-mediated signaling events’ from PID; (B) ‘Signaling of hepatocyte growth factor (c-Met)’ from BioCarta; (C) ‘Growth hormone signaling pathways’ from BioCarta 682 5566 2885 10855 3082 8573 3265 7038 5781 1398 5728 3725 PMC2908016__F2 Therapeutic HPV vaccines 367 940 920 PMC2908510__F3 Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family 367 1956 2064 3479 9846 3667 PMC2908610__F1 Death receptor pathway via Fas ligand and Fas receptor 355 8772 637 PMC2912609__F2 Currently available therapies targeting EGFR signaling pathway 1950 1956 673 5163 5728 2475 PMC2912611__F8 From HLA-B27 to spondyloarthritis: a journey through the ER 51752 149233 7054 PMC2913704__F6 TGFB1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation 4089 4087 4088 7040 4851 PMC2917144__F1 Toll-like receptor signaling pathway 7099 4615 114609 7189 3654 3663 51135 7334 10454 29110 23118 257397 3661 PMC2920636__F5 Molecular networks over-represented by E 7058 5329 5328 7424 5340 5327 5771 27063 6513 51069 6136 4609 26292 80273 PMC2922838__F2 Gene expression profiling in whole blood of patients with coronary artery disease 790 4709 4694 836 PMC2924553__F1 BMP signal transduction 4090 4086 331 6497 4089 51701 1499 PMC2928709__F4 Observation of the differentially expressed genes on the human cell cycle (A) and transforming growth factor beta (TGFB) signaling pathways (B) modified from Kyoto Encyclopedia of Genes and Genomes (KEGG) (www.genome.jp/kegg/kegg1.html) 2033 4193 5591 4088 9978 8454 4089 9232 6502 7157 11200 1111 7532 5111 898 902 1017 1022 5925 7465 25 5933 1869 51270 8317 8178 8646 9241 268 5073 7124 7059 7057 7060 7058 6500 7027 4609 1634 6667 387 5515 94 90 10468 93 92 5308 4838 PMC2929006__F5 Genetic basis of kidney cancer: a metabolic disease 201163 5728 572 7249 7248 57600 96459 PMC2929310__F3 Transcript abundance patterns in Kawasaki disease patients with IVIG resistance 1053 268 949 634 177 7124 1535 3604 51130 PMC2930200__F1 Molecular machinery of myelin gene transcription in Schwann cells 6657 6663 4359 4155 PMC2933206__F7 Hypothetical model of how Str1 may affect cellular behavior via the Beta-catenin/LEF signal transduction pathway 999 474168 1499 324 595 4397 PMC2934757__F1a Defining the pathway to insulin-like growth factor system targeting in cancer 3479 3481 3480 3482 2885 3667 PMC2936527__F1 Synthesizing and Salvaging NAD+: Lessons Learned from Chlamydomonas reinhardtii 125061 8564 8942 10135 93100 PMC2936760__F5 Signaling pathways described in ARPE19 cells 948 5163 8195 PMC2938013__F9 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development 27185 85458 2932 1499 81565 1020 PMC2939005__F1 Two major insulin signaling pathways 3630 7054 2885 PMC2940478__F3 Web-accessible GnRHR pathway navigator 367 5978 978 PMC2941735__F2 Targeting Non-Homologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization 1950 7039 1956 5728 5163 PMC2943518__F7 Diagram of a putative LPS-induced PTP/LITAF/TNF signaling pathway 7097 7099 9516 11156 PMC2944186__F1 Convergence between Wnt and EGFR pathways 7039 1956 4040 4041 85409 1499 PMC2945811__F1 FA-regulated ICL repair 57697 91442 545 84126 22909 PMC2948618__F3 3rd US-EU Workshop Systems level understanding of DNA damage responses 472 545 993 994 995 PMC2951227__F7 Hypothetical model for Rad18-dependent activation of the FA pathway in response to bulky DNA adducts 353497 56852 5111 4173 4176 4172 4171 4174 4175 PMC2952341__F1 Alteration of Notch signaling in skeletal development and disease 3516 5664 5663 23462 3280 182 3714 28514 10683 54567 8788 51176 65989 PMC2953449__F3 Different effects of gut- and brain-derived serotonin on the osteoblast 3358 3351 154 9575 468 PMC2953617__F2 JS genes implicated in the Shh, Wnt, and PDGFA signaling pathway 6469 56623 200894 5108 54806 80184 PMC2955995__F1 Targeting Notch signaling pathway to overcome drug-resistance for cancer therapy 4851 4853 4854 4855 100188776 PMC2959043__F3 Wnt/Beta-catenin signaling Ctenophore pathway 1499 324 4040 4041 PMC2964935__F5 PAR Proteins: Fundamental Players in Animal Cell Polarization 7074 387755 5728 6010 8650 PMC2966096__F7 A hypothetical model of PAR-1 and PAR-2 activation by coagulation proteases when either EPCR or an unknown FX/FXa receptor is occupied by natural ligands 7054 5091 857 324 387 5879 PMC2971463__F3 SLIT/ROBO pathway: a regulator of cell function with implications for the reproductive system 3082 2885 2932 1630 7852 1499 5266 PMC2971525__F1 DNA Damage Response (DDR) pathways in normal and malignant cells 545 3014 995 993 581 355 1017 2308 PMC2975074__F3 Cell stress response: activation of the aggresome pathway, HSPs, and transcriptional response 7415 3297 10013 PMC2975092__F6 Biological interaction between glucose and genes up- (light grey) or down-regulated (white) in primary hepatic stellate cells after overexpression of Smad7 2052 3082 3099 7025 1571 4023 1410 1978 9590 2026 5214 5747 1264 7422 4092 3486 PMC2976339__F5 Gene expression within cluster MCL2 is enriched in genes affecting NK cell-mediated cytotoxicity 3106 3107 3133 27040 7535 6850 126669 3466 355 836 637 55364 PMC2981097__F2 Double strand DNA repair: Homologous recombination and Non-homologous end joining 472 7157 83990 672 59348 79728 10111 675 7517 7516 3014 3981 7518 5888 8438 5893 5885 367 PMC2989646__F4 The involvement of zinc metalloproteinases in AB metabolism 8754 102 8751 6868 101 8728 351 80332 3416 1889 1636 PMC2989686__F4 Canonical pathways for cardiovascular disease 629 4151 5345 1361 5340 5054 PMC2989866__F2 The Regulation of the CNS Innate Immune Response Is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review 718 2271 1378 727 966 PMC2989879__F2 The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system 472 5728 1499 10370 4513 PMC2989879__F3 The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system 10370 664 4899 PMC2992886__F3 Genes associated with autoimmunity regulate the CD40/NFKB signaling pathway 958 7186 7185 108348016 PMC2993794__F1 Stimuli and factors involved in yeast chronological aging 7054 2021 27429 PMC2995293__F2 Immune and central nervous systems interact and contribute to the etiology and pathophysiology of cytokine-induced depression 3558 1401 7454 3553 1392 627 PMC2997006__F1 Tor pathway in the model fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe 7248 7249 6009 PMC2997573__F1 The current understanding of PELP1 signaling pathway 1950 1956 6714 27043 5548 7536 PMC2998292__F1 Estrogen and Tamoxifen Metabolic Pathways depicted at the genomic level 1586 1588 1576 1545 1565 1312 5241 1555 PMC3002356__F6 Proposed model of GS-mediated apoptosis in HNSCC cells 8772 572 581 637 PMC3003336__F4 FLCN pathway 201163 5728 572 7249 7248 96459 57600 PMC3004266__F10 Active Cdk1/cyclin B1 complex on the extrinsic death pathway 355 8772 891 983 PMC3004524__F4 Model of pri-miRNA processing and localization 29102 5901 27161 100187761 PMC3010981__F1 Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells 6778 4586 727897 PMC3011892__F4 Cell cycle pathway containing Treponema denticola differentially regulated genes in calvarial bone compared with sham-infected controls at P ≤ 0.05, adapted from Pathway Express and using the Kyoto Encyclopedia of Genes and Genomes nomenclature 9184 5111 1017 1022 4661 PMC3011892__F5 Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles 7851 5111 1022 1017 1869 4999 PMC3011942__F1 Phosphatidylinositol 3-kinase-Akt (PI3K-Akt) pathway becomes activated via stimulation of receptor tyrosine kinases (RTKs) and the assembly of receptor–PI3K complexes 5163 5164 5728 5879 998 2475 2932 572 4193 PMC3016145__F1 Intracellular and extracellular chromogranin/secretogranin actions 1113 4852 7857 1114 PMC3022513__F1 Physiological regulation of the mTOR signaling pathway 5728 7249 6009 2475 1499 1977 PMC3023199__F3 PPARG ligand treatments increase expression of mitochondria-associated metabolic pathways in adipose tissue 1962 587 5095 217 7216 PMC3028977__F6 CD36 contributes to inflammation and impaired insulin signalling in adipocytes and macrophages 948 2534 4067 PMC3031545__F8 Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B 3479 355 7350 PMC3032410__F7 Dynamic Distribution of CARD11 at the Immunological Synapse is Regulated by the Inhibitory Kinesin GAKIN 324 940 84433 7189 PMC3034644__F2 Self-regulation in Xenopus dorsal-ventral patterning.The pathway consists of a network of BMP-interacting proteins 650 652 655 PMC3035032__F3 Simplified schematic illustrating molecular mechanisms of neurite regulation 5662 2534 6010 998 399 6774 23242 5728 PMC3037729__F1 Interaction between PI3K/Akt and Wnt signaling pathways mediates diverse cellular effects through downstream messengers 2932 2308 2475 1499 PMC3038181__F1 Activation of the PI3K/Akt pathway in cancer 7189 1956 2549 5728 5163 11191 64798 PMC3038250__F4 PI3K/Akt and RAS/BRaf/MEK pathways are frequently altered in melanoma 5728 10000 673 PMC3041769__F4 Antibodies against CD20 or B-Cell Receptor Induce Similar Transcription Patterns in Human Lymphoma Cell Lines 10346 1643 597 6242 949 7378 6955 1390 596 3161 7408 2113 27071 5552 489 PMC3043094__F3 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach 5481 5350 857 858 859 613 952 PMC3043094__F4 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach 7975 3925 4803 8314 4351 2885 6722 2316 3725 7124 7186 1616 4149 4208 929 23118 51701 PMC3043245__F3 Signalling between p53 and the IGF-AKT-mTORC1 pathway 472 3486 5728 7249 7248 6009 4193 PMC3044050__F6 Spry2 and Spry2Y55F function in the context of EC MAPK signaling 2885 6654 10253 5894 PMC3046528__F6 Monosodium urate (MSU)-mediated inflammation and the roles of spleen tyrosine kinase (Syk) and Nlrp3 3603 6850 64170 PMC3048376__F2 Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli 7039 1956 7186 85451 101180900 PMC3049118__F3 Endocrine system development and function genes increase in the spleen of CVB3 infected males at 12 h pi 11080 55466 7472 8404 11278 6794 332 23541 27429 1111 367 2288 2547 5358 6934 4481 PMC3049553__F1 MAPK pathway activation in melanoma 4893 2776 2885 6714 5728 2475 PMC3049852__F1 Multifunctional effects of CMKLR1 activation 1240 6850 6714 2475 PMC3050844__F5 Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes 100187761 10664 367 4118 1018 PMC3056800__F7 Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds 2638 8833 64853 435 9615 PMC3057180__F1 Backup DNA repair pathway 672 6741 27434 PMC3057180__F2 Exploiting synthetic lethal interactions for the treatment of human cancer 472 2695 545 PMC3057977__F3 Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis 5901 983 1434 1104 324 991 22974 4926 1431 PMC3058407__F1 Antiviral apoptotic pathway is mediated by IRF-3 and Bax 64127 7187 29110 581 3661 100187761 7099 7098 7186 7189 PMC3058926__F5a Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations 26960 1845 12 5909 3459 4051 23175 6288 9180 10370 3172 1499 2877 6319 1315 10628 6280 7518 65018 1070 9076 PMC3060045__F2 ErbB receptor signaling and regulation 1956 2064 1950 2066 7039 2549 2885 126669 6714 3717 2060 51741 PMC3060494__F6 RPA/9-1-1- and hMSH2-mediated ATR activation in DNA damage signaling 4436 2956 84126 11073 545 PMC3061506__F1 Integration of the identified proteins into the canonical pathway of TLR signaling 100187907 54472 3725 PMC3061884__F9 100 frequent associations obtained after p value cut off in MCL with CDCOCA 28988 7534 6156 8439 6605 84433 7010 9618 PMC3068924__F4 CAERUS: Predicting CAncER oUtcomeS Using Relationship between Protein Structural Information, Protein Networks, Gene Expression Data, and Mutation Data 5091 4893 7037 5062 6503 3416 6010 3725 673 50964 5898 60 3055 892 324 1017 PMC3070859__F1 Cohesin regulates expression of genes that control differentiation, morphogenesis, proliferation, and pluripotency 4609 79923 25836 10735 PMC3071916__F2 Insights into the Pathogenesis and Treatment of Cancer from Inborn Errors of Metabolism 2271 3417 3418 PMC3072047__F1 Carbon flux rerouting during Mycobacterium tuberculosis growth arrest 7086 101241897 1737 355 96764 PMC3073487__F4 Functions of 14-3-3 in tumor-suppressor pathways 4485 9113 26524 1499 PMC3073855__F1 Childhood Obesity – 2010: Progress and Challenges 5443 1363 181 4852 627 1392 7200 5697 PMC3075071__F1 Parsing out the complexity of RAF inhibitor resistance 4893 369 5159 PMC3077082__F2 Microbial manipulation of receptor crosstalk in innate immunity 23601 920 387 4615 4046 6850 5894 3569 7124 7054 PMC3077082__F3 Microbial manipulation of receptor crosstalk in innate immunity 727 7852 7099 2932 PMC3079374__F1 Simplified schematics of the MAPK and PI3K pathways in melanoma and the clinical compounds available for their inhibition 673 5728 369 2475 253260 PMC3080846__F1 Innate Immune Sensing of DNA 9447 4615 54106 57506 1499 7187 11277 PMC3081520__F2 Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease 3920 9474 79087 8678 22863 2475 PMC3083931__F1 Canonical and noncanonical nuclear factorKB (NFKB) activation pathways 958 4055 8887 83737 26994 5971 5970 PMC3084294__F4 The Complete Genome Sequence of ‘Candidatus Liberibacter solanacearum’, the Bacterium Associated with Potato Zebra Chip Disease 11113 4118 1431 PMC3085710__F4 KEGG Pathway Map () 2149 7035 3053 2152 1361 2155 2159 2147 2153 2160 2158 2157 7056 462 2 5624 5054 5627 5265 5327 5329 5328 2161 5340 3818 5345 966 718 729 730 735 721 5648 10747 717 720 719 710 1380 1378 PMC3086058__F1 Representation of genes of the vascular endothelial growth factor (VEGF) signaling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib, and cilengitide are known to act 2321 7423 7422 2247 7078 5281 8829 3791 1398 1445 10818 2885 6654 5894 4846 PMC3087179__F5 IL-4R Drives Dedifferentiation, Mitogenesis and Metastasis in Rhabdomyosarcoma 3597 3598 6778 PMC308804__F4 Visualizing protein interaction networks in HPRD 1399 3932 1051 6714 4703 6850 828 2885 4986 6654 1398 1814 3791 1432 PMC3089575__F8 Proposed interconnection between PE synthesis and conversion (PL interconversion triad) during LD biosynthesis 7038 10400 5091 5662 PMC3089884__F5 Chemokine Signaling Pathway 126669 1191 5896 PMC3091517__F1 Ras/Raf/MEK/ERK Pathway and Potential Sites of Therapeutic Intervention with Small Molecule Membrane-Permeable Inhibitors 2885 1977 6194 1975 PMC3091517__F3 Interactions between the Ras/Raf/MEK/ERK, Ras/PI3K/PTEN/mTOR and Wnt/Beta-Catenin Pathways that Result in the Regulation of Protein Translation and Gene Transcription 7249 7248 6009 57167 PMC3091753__F3 Representative genes that responded to [BF/S+L/Ep] treatment 2920 126014 4317 6503 154796 4685 5473 1008 57045 8517 324 4790 6059 84532 51676 6847 11144 10432 55553 5055 9378 8864 5947 9261 208 331 152831 3064 6722 6667 57491 PMC3095999__F2 Literature-based connections among genes in altered modules of head and neck squamous cell carcinoma (HNSCC) 8877 3553 10631 12 4609 4318 1956 6364 374 3624 PMC3096022__F1 Biochemical pathways leading to the synthesis of TAG and cholesterol 6319 3156 2194 PMC3097115__F5 PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans 7536 11338 6629 6627 27336 10262 10291 23451 23450 10946 10921 51690 9092 153527 23658 7737 25949 55696 8896 58509 11052 24144 23398 22944 9416 51634 22827 PMC3097389__F1 CoQ10 biosynthesis pathway 23590 57107 27235 51805 51004 84274 10229 PMC3098994__F1 Genetics of Mechanosensation in the Heart 3611 2273 4077 6722 PMC3100630__F1 EGFR biology 1956 2885 7249 7018 4513 PMC3103151__F1 Intracellular pathway of folate metabolism with highlighted critical pathways of methotrexate (MTX) entry, effect and efflux 5981 10257 100 5243 8714 1244 8836 2356 471 2618 4397 875 4524 PMC3108840__F7 Functional pathway analysis of glycoproteins overexpressed in PC3-ML2 9118 10631 54798 5411 3728 1057 8170 682 57506 10994 PMC3109603__F7 Comparative pathway networks of cyclic genes in mouse, chicken and zebrafish 22943 8313 51339 85407 79023 11072 1846 1843 1844 1848 3280 388585 3397 389058 55504 23462 441478 PMC3110682__F1 Hypothesized mechanisms of physical activity in colon cancer 4513 3479 324 PMC3117645__F9 The miR-29 regulatory network in Zmpste24−/− progeroid mice 26502 8493 1844 26959 170692 4613 10437 998 PMC3118263__F4 Pathway analysis links the differentially expressed gene signatures of the MED29 transduced Hs 700T and MIAPaCa-2 cells to a cellular network involved in cell cycle, cancer, and genetic disorder 5796 55355 54998 1058 699 6790 9212 9232 2305 55143 22974 3161 54602 995 3964 PMC3118552__F7 Activation of the Stress Protein Response Inhibits the STAT1 Signaling Pathway and iNOS function in Alveolar Macrophages: Role of Hsp90 and Hsp70 3716 3717 6772 PMC3122626__F4 Key cellular signaling cascades regulating morphogenesis in C 4004 3084 5879 59272 PMC3122626__F9 The calcineurin signaling pathway in C 4281 2357 5954 1255 1357 1358 PMC3123543__F4 Overlaid networks predicted by the PLS method and generated by IPA pathway designer 1998 90007 26136 2069 PMC3127250__F1 Autophagy and the integrated stress response 2475 7405 9776 8408 9706 55626 81671 10533 64422 83734 9140 PMC312742__F9 Role of E2F1 in the DNA damage response 472 545 1019 1869 4193 1870 1871 PMC3128635__F2 Crosstalk and feedback in ERK and PI3K signaling downstream of RAS 5728 5163 3667 PMC3130501__F1 Intrinsic and extrinsic apoptotic pathways 572 8772 637 581 331 PMC3132554__F2 Small-molecule inhibitors of the PI3K signaling network 5728 5163 7249 6009 7248 572 842 4193 PMC3135645__F1 Coordinated regulation of p53, target of rapamycin (TOR), and insulin/insulin-like growth factor 1 (IGF-1) pathways 3479 5728 5163 6009 4193 PMC3136693__F1 Chemical heme biosynthesis pathway 210 7390 91653 7389 130749 PMC3140053__F1 Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk 3569 3572 4513 6774 7124 6387 3586 7852 PMC3140692__F3 Hypoxia regulates other critical pathways that impact tumor progression in a HIF-independent fashion 6009 7249 1977 5371 83939 PMC3140915__F1 Simplified schematic of the Wnt/Beta-catenin signaling pathway 324 2932 1499 PMC3141288__F3 Roles of NFKB-mediated inflammatory pathway in cellular transformation, cancer survival, proliferation, invasion, angiogenesis and metastasis 595 7852 7124 3383 4513 7412 331 PMC3142564__F1 Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer 4018 5728 5163 2475 5879 4193 2932 572 PMC3143377__F3 Molecular Targeted Approaches in Mantle Cell lymphoma 695 29760 2475 PMC3143902__F1 Inhibition of myostatin (MSTN) and activin signalling by the soluble activin type IIB receptor (ActRIB) 238 4088 4087 PMC3146606__F2 PARP function in base excision repair and consequences of PARP inhibition 6741 4361 472 10111 5893 6118 5888 672 7515 8505 PMC3148828__F4 KEGG pathway: cell cycle 545 472 9184 4088 4089 6502 991 5111 1017 1022 PMC3149764__F3 Emerging roles of JAK–STAT signaling pathways in adipocytes 3458 3976 5008 5617 PMC3151428__F3 Suppression of anaerobic metabolism by p53 is mediated through multiple pathways 57103 5728 3099 PMC3152294__F1 Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism 367 388585 3280 23493 23462 4855 4853 4851 4854 PMC3153965__F7 Network representation of altered cellular functions during colonization of the mouse colon by A 1356 6404 1386 4478 948 2147 2113 6693 4179 3111 917 933 915 3112 1879 5790 3565 3109 PMC3155287__F1 Autophagy regulation 5894 5728 7249 7248 6009 2475 64223 PMC3155635__F3 Functional pathway analysis of the 12-gene genomic instability signature using Ingenuity Pathway Analysis 6362 7124 3586 4585 959 7018 596 6648 842 7015 3169 4609 1029 896 1019 1869 4602 10482 9939 6790 7157 22974 22794 30000 891 PMC3157194__F4 Interaction between MAPK signaling pathway–related genes and miRNAs 22808 3845 2353 51701 1956 4908 PMC3159106__F2 TLR-mediated myeloid differentiation primary response gene 88 (MyD88)-dependent and TIR domain containing adaptor inducing interferon (IFN)B (TRIF)-dependent signaling pathways 4049 929 7096 7097 7099 7100 10333 114609 4615 51284 7189 23118 257397 29110 3661 PMC3159112__F5 Ad signaling in endothelial cells 79602 51094 7124 PMC3159954__F3 Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa 9978 9636 23304 10346 PMC3160099__F7 Pathways that control the onset of adulthood and the terminal differentiation of specific cell lineages are conserved from C 7536 2268 3972 389421 PMC3161872__F1 Summary of TNFR signalling 7124 8717 7186 8772 PMC3164770__F5 FLCN pathway 201163 8544 5728 7249 572 7248 96459 57600 PMC3165008__F1 An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis 27240 6955 1072 3166 PMC3165102__F1 TGFB/SMAD/GLI2 signaling axis in cancer progression and metastasis 51684 2736 6608 4088 2735 5744 7474 4089 595 PMC3166148__F3 The citric acid cycle pathway (reprinted from KEGG ) 5162 4190 50 8803 8801 PMC3169412__F1 Fatty-acid biosynthetic pathway for R 2194 2242 355 2353 367 2091 52 PMC316957__F9 How ECSIT may participate in Toll/IL-1 signaling 7124 8717 4615 7186 7188 7189 51295 PMC317036__F5 Model showing the possible relationship of dTOR with the insulin pathway 5728 5163 1977 PMC3170851__F2 The Multifaceted Roles of Autophagy In Tumors--Implications For Breast Cancer 4077 8161 9817 PMC317132__F1 Model of somatic sex determination in C 6382 6383 9672 29896 PMC3175556__F7 Schematic diagrams of the signal transduction in TCDD-induced MUC5AC gene expression and the conventional AhR pathway in the activation of CYP1A1 expression 1956 196 6667 405 PMC3175712__F1 (A–C) Schematics of Wnt signaling components in the absence of a Wnt signal (A), the presence of a Wnt signal (B), and the presence of a Wnt signal blocked by the displacement of Tcf7l2 by dnTcf7l2 (C) 324 2931 2932 1499 6873 PMC3176306__F1 New strategies in Prostate Cancer: targeting lipogenic pathways and the energy sensor AMPK 1977 2475 6009 7249 7248 47 2194 95 PMC3180925__F1 Wnts signal through a “canonical” pathway involving Beta-catenin mediated transcriptional regulation (at left) and through “non-canonical” pathways involving calcium and Rac/JNK-mediated signaling (at right) 1499 324 355 PMC3182268__F1 Apoptotic pathway to cell death from the perspective of the Bcl-2 family of proteins.1, The intrinsic pathway is initiated by various signals, principally extracellular stimuli 355 637 572 581 PMC3185489__F1 Diagram connecting the insulin pathway and fatty acid (FA) biosynthesis 3667 2475 355 6319 4018 PMC3185522__F3 HCV induces the over-expression of PP2Ac via an ER stress response pathway 3455 3716 7297 6772 3276 PMC3190874__F2 FcERI signaling pathway is negatively regulated by a number of cell surface and intracellular proteins that act at various points in the FcERI signaling network 7099 27040 54795 1445 2534 4067 6850 695 PMC3195227__F1 A schematic diagram of the kynurenine pathway 8564 8942 130013 23475 PMC3196058__F2 Dynamic Role of Beta-Catenin in Synaptic Plasticity 790 2932 324 PMC3196377__F6 Regulator of G Protein Signaling 6 (RGS6) Mediates Doxorubicin-induced ATM and p53 Activation by a Reactive Oxygen Species (ROS)-dependent Mechanism 9628 472 4193 PMC3198803__F5 CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae 5805 51083 6908 64127 PMC3198933__F1 Toll-like receptor (TLR) signaling 7100 51311 51284 54106 7096 7097 7098 7099 10333 4118 4615 29110 7189 3661 3663 7124 PMC3204314__F7 Signalling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis 64220 9021 3717 PMC3204462__F1 TRAIL signaling pathway and regulatory proteins 8772 64112 116985 10419 7818 23237 637 4170 7186 581 572 331 842 PMC3206070__F2 Temporal Order of Genetic and Pathway Alterations in Tumorigenesis 324 7157 3845 132884 6934 2042 4089 1029 7837 7048 1956 3417 5728 5290 5925 PMC3209293__F6 IA30-infected pigs fail to induce immune response genes associated with pattern recognition of viruses and cytokine and immune cell responses in the lung 3456 64135 3627 5721 5720 3665 10673 2634 1230 958 3383 4615 51311 3718 2207 22914 3937 6850 7305 695 29760 118788 7124 3480 PMC3212439__F5 Immunoproteasomes Regulate Lps-Induced Trif/Tram Signaling Pathway in Murine Macrophages 7099 4615 7189 7187 3661 7124 6772 PMC3213160__F3 Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling 2056 613 3562 1956 3574 3567 472 100170220 PMC3213398__F7 Working Model for the Late-Acting Function of NFU1 in Mitochondrial Fe-S Protein BiogenesisThe findings of this work suggest a late-acting function of NFU1 in the pathway of Fe-S (red and yellow circles) protein maturation 23479 200205 81689 9054 4758 27247 PMC3213765__F12 Schematic of the sonic hedgehog signaling pathway 6469 6608 51684 PMC321431__F10 Cascade of transcription factors that induce stress gene expression in response to eIF2A phosphorylation 468 467 22926 1386 PMC3215729__F1 Rv2607 from Mycobacterium tuberculosis Is a Pyridoxine 5′-Phosphate Oxidase with Unusual Substrate Specificity 3651 5355 4860 PMC3216974__F7 S6K1 and 4E-BP1 Are Independent Regulated and Control Cellular Growth in Bladder Cancer 8544 5163 5728 7249 7248 6009 PMC3217196__F1 MicroRNAs in Mutagenesis, Genomic Instability and DNA Repair 3014 693215 545 472 693122 993 998 442917 442918 900 PMC3218904__F1 Network pathway analysis of up-regulated genes in the gene category immune response 953 7852 6892 11027 3134 5777 3133 311 9120 8824 22904 3958 8527 26253 7512 3172 55224 85406 3748 143 79807 4188 1822 863 51107 8916 PMC3218933__F2 Cross-talk among embryonic signaling pathways and experimental inhibitors 6608 4087 4088 2932 5728 4089 3280 3714 23462 100188776 22943 27122 6422 182 1499 3549 2296 2885 PMC3223722__F1 Glycogen synthase kinase 3 modulates the function of key signaling proteins in the wnt pathway 1499 324 4609 PMC3223826__F5 JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors 3026 3611 960 3550 4088 9442 5740 7431 3856 5209 9636 PMC3226194__F7 An integrated pathway model involving FOXA1 in breast cancer 472 3169 672 675 5888 1562 2053 50814 PMC3228010__F1 Signaling pathways of sunitinib and sorafenib cardiotoxicity 5894 572 2475 1938 581 PMC3229968__F2 Deciphering the role of Nuclear FactorKB in cellular senescence 472 23118 7189 PMC3229968__F3 Deciphering the role of Nuclear FactorKB in cellular senescence 23411 7249 7248 5728 5163 6009 2475 PMC3236328__F2 The differentiation hierarchy within the mammary epithelium and potential relationships with breast cancer subtypes 5971 100133941 3815 2064 PMC3238182__F1 Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors 1950 2885 8061 7227 9839 6935 999 1956 PMC3238353__F2 Crosstalk between UPR signalling pathways and lipogenesis 22926 83939 3638 338 468 5465 PMC3238469__F2 Gene expression changes in cell cycle pathways 2146 645121 2175 3364 5743 5595 9261 4436 545 472 2176 259266 5426 PMC3240145__F2 Intrinsic and extrinsic pathways of apoptosis 581 8772 637 56616 PMC3240659__F3 Repeated Small Perturbation Approach Reveals Transcriptomic Steady States 7869 3398 678 836 1026 5366 1647 7157 7357 81539 7048 4176 1266 2012 5743 4092 7514 PMC3241824__F1 Operation of the mammalian Hippo pathway in mouse intestinal epithelium and human colon cancer 4485 10413 1499 PMC3241972__F1 TOR in the immune system 7248 7249 6009 253260 64798 2475 64223 1977 PMC3242881__F6a Src REGULATES SPHINGOSINE-1-PHOSPHATE MEDIATED SMOOTH MUSCLE CELL MIGRATION 1901 1903 6714 2932 PMC3243339__F8 Depiction of how D1 and c-Myc proteins regulate CDDP-induced cell death, with arrow indicating induction and hyphen (-|) indicating inhibition 5970 5971 4790 332 PMC3245201__F1 Topography and signaling pathways triggered by selectin ligands in neutrophils 960 3055 2268 4067 6850 695 5336 PMC3247754__F3 Simplified view of the glucose sensing mechanisms in S 23440 201626 100131187 27010 3084 PMC3250228__F3 FOLATE-ALCOHOL AND CANCER PATHWAY HYPOTHESES 875 4524 1571 1719 10840 PMC3254618__F3 Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome 759 100187761 367 1325 572 PMC3257753__F1 TWEAK-Fn14 signaling system 7186 7188 7189 8195 PMC3258214__F1 Bcl-3 signaling cascade 1540 7124 3586 6774 PMC3258432__F6 Factors shown to promote or inhibit the vascular normalization phenotype in tumors 1956 2475 388 7422 56034 80310 5281 8829 1003 5155 8490 PMC3259514__F1 Different signaling pathways leading to the induction of virus stress-inducible genes (VSIGs) and interferon-stimulated genes (ISGs) 3717 3716 7189 3654 51135 29110 10379 6772 6773 23118 3661 10454 1386 3659 PMC3260150__F2 Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer 8837 1616 572 8728 10402 8790 PMC3260807__F2 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health 1956 126669 6714 6009 2475 4193 572 150365 PMC3261278__F2 Targeted treatments for fragile X syndrome 23237 5728 2475 23191 PMC3262916__F2 Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment 1499 7421 324 PMC3263309__F1 Notch, Wnt, and Hedgehog signaling pathways regulate normal and stem cell fate 6608 324 1499 4609 960 9794 100188776 PMC3263503__F8 Schematic depiction of crosstalk between Notch and HIF-1A 6774 1977 7428 5230 100188776 1387 PMC3263596__F3 TGFB pathway in NetSlim 6497 9146 998 6093 4087 83737 389692 4088 324 2353 4321 7015 3371 PMC3263689__F5 FLCN pathway 201163 5728 7249 572 57600 96459 PMC3265866__F7 PGC-1Alpha- and AMPK-mediated regulation of IL1Rn expression in hepatocytes 5465 3557 1401 3553 PMC3267157__F2 P73 pathway and its regulators.A simplified view of the p73 pathway, of its regulators, and of the molecules that directly or indirectly can modulate its function 472 7249 7248 2475 5300 145270 83737 4193 PMC3267662__F2 IGF1R-IR/PI3K/Akt/mTOR pathway and its manipulation through diet 3479 3480 2475 PMC3268188__F2 Tumour suppressor p53 regulation and signalling 472 545 4193 581 27429 355 50484 PMC3270883__F1 Exiting from uncharted territory: hepatitis C virus assembles in mouse cell lines 949 9076 975 100506658 3949 348 PMC3272882__F3 DRD2/GSK3B/DISC1 pathway modified from Beaulieu et al 1813 207 27185 1499 PMC3277127__F5 Curation of phosphoproteomic profiling and bioinformatics delineates distinct tyrosine kinase signaling pathways in an oncogene-specific manner 2078 5770 1956 1500 5786 6714 5335 367 7414 857 5829 3717 6774 1969 2185 2885 4067 3845 PMC3277752__F2 Browsing the ApoptoProteomics database 572 8772 637 331 PMC3278830__F3 Functions related to hepatic cultures.Subgraphs of a hepatocyte response network induced by genes annotated with MSigDB gene sets 3655 22800 5217 3672 29882 7465 5696 4893 81 1111 2246 4175 79784 4257 131 1571 10941 373156 10062 2494 3172 2947 6258 PMC3281571__F2 MTOR pathway 2475 7124 3667 6510 5728 5879 387 8140 6520 5163 64798 253260 64223 7249 6446 7248 5371 664 6009 2887 8408 9776 1977 1975 1938 84232 7528 2885 PMC3282414__F2 Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities 4204 3265 4763 85358 5728 5163 5164 2475 22941 23237 PMC3285363__F7 Hypothetical scheme illustrating a possible mechanism of mLDL-mediated regulation of C3 expression and secretion by human macrophages 718 7099 929 PMC3285457__F6 Smad7 is Inactivated through a Direct Physical Interaction with the LIM Protein Hic-5/ARA55 4087 4088 4092 367 PMC3286676__F1 Thyroid iodide efflux: a team effort? 50506 7173 7038 7253 PMC3287579__F1 Adapted from 5183 5091 5879 PMC3288889__F5 Ephrin-B cleavage and signaling 1445 6714 1499 PMC3289952__F1 Selected essential fatty acids molecular mechanisms 19 10350 9619 PMC3292500__F3 Top scored pathway map affected by BaP "Apoptosis and survival_Endoplasmic reticulum stress response" 22926 581 100187907 1965 468 637 PMC3292584__F4 Differential gene expression in the TLR signalling pathway 3929 23643 929 7097 51284 7098 7099 114609 4615 7189 51295 23118 8195 3551 1147 4792 2353 3725 PMC3293935__F4 Known apoptotic targets of P53 355 637 842 836 64065 5728 54541 23612 PMC3294426__F3a Into the Eye of the Cytokine Storm 3552 7124 115650 943 8784 55504 23495 25759 2885 6654 608 53358 6655 399694 4615 8835 3654 9021 122809 30837 3265 3845 51295 8717 10454 6885 4214 5781 4217 8737 5608 23043 5603 1432 4793 4794 6774 5604 3725 1051 6925 3929 5004 5005 2243 197 335 336 350 3273 3240 3263 3698 183 5947 5948 629 2266 6289 2335 716 3699 6648 727 735 PMC3294670__F7 Mechanisms of control of Listeria entry by the type IA PI 3-kinase signaling pathway 5163 5879 23075 116984 28964 207 208 27071 2475 5878 382 PMC3294814__F1 Proposed biosynthetic pathway of RQ (compound 1) 7054 27235 51004 84274 10229 51805 PMC329503__F9 The roles of Ras and Mob2 in S 55824 81532 27010 6010 59272 PMC3295030__F1 Simplified description of the insulin/IGF-1 signal transduction (IIS) pathway in invertebrates and mammals 9798 8471 3667 8660 2885 5728 207 208 5163 10000 4303 100132074 2002 PMC3295195__F10 A novel mechanism linking ROS/Src/caveolin-mediated activation of the EGFR-ERK signaling pathway to chronic Ang II exposure-induced EMT in cultured renal tubular epithelial cells 1839 857 1956 PMC3296207__F1 Intrinsic and exrtinsic pathways of anoikis 638 572 90427 56616 331 8772 PMC3299554__F1 Diagrammatic representation of the Akt signaling pathway.Notes: Activation of receptor tyrosine kinase (RTK) by growth factor binding activates PIK3 5163 5728 2475 572 595 4193 PMC3307881__F5 Inhibition of the Nedd8 system sensitizes cells to DNA Inter-strand crosslinking agents 472 545 5111 2177 PMC3309723__F5 Parp1 mediation of Sox2 activity in ESC pluripotency 3976 142 6774 8505 6657 79923 PMC3310050__F12 Folate Decorated Dual Drug Loaded Nanoparticle: Role of Curcumin in Enhancing Therapeutic Potential of Nutlin-3a by Reversing Multidrug Resistance 596 4193 581 637 PMC3312242__F1 Regulation of cancer stem cells by inflammatory cytokine networks 3577 6774 5728 1540 5970 PMC3312985__F4 Genes identified as part of the significant Para-ICA networks highlighted on a KEGG Alzheimer’s pathway diagram derived from the DAVID functional association tool 174 23385 3416 4023 572 8772 836 637 759 6622 5091 4508 26136 PMC3312987__F2 Commonly mutated pathways in glioblastoma 5728 4763 1021 1019 PMC3313874__F2 Networks built using differentially expressed genes in uninfected macrophages from C57BL/6 and CBA mice 133418 91543 283571 9518 4493 3588 1075 57085 23705 3107 PMC3314445__F9 An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated AB oligomers 28 2740 3667 PMC3315579__F4 Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era 1956 5728 5163 2475 PMC3323522__F7 A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity 1581 80270 1593 PMC3327812__F7 Protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2 3667 7186 2874 3569 PMC3328609__F3 Development of the Bile Ducts: Essentials for the Clinical Hepatologist 2932 324 1499 PMC3334602__F7 Cordycepin analogues and the C 132 4907 100 4860 PMC3334709__F4 Tau neuroinflammatory cascade 3569 1020 3553 968 PMC3334963__F7 Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing 4615 695 51135 7187 7189 29110 3663 3665 6772 3661 5292 7097 PMC3334963__F8 Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing 8717 7186 51135 27069 5728 11113 51074 842 351 23017 355 PMC3335376__F4 Illustration of p53 TIAs in lymphocytes 581 572 4199 150365 637 842 2475 836 PMC3335376__F8 Therapeutic modulation of the TP53 pathway 472 545 4193 133746 27085 5728 6659 5371 6996 641 7486 4282 3569 6774 8772 8837 637 150365 331 PMC3335938__F1 Key therapeutic targets in the PI3K/Akt and MAPK pathways together with pharmacological agents inhibiting members of these signaling cascades 5728 5266 10000 4193 2475 7465 572 595 PMC3336107__F1 The Unfolded Protein Response in the ER 22926 7494 468 PMC3338086__F1 Canonical and non canonical NF-kB pathways and related drugs inhibition 958 613 6007 5971 5970 PMC3338536__F4 TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators 23435 4001 4478 1413 6449 7316 3792 3150 5717 10992 10219 5557 5425 325 PMC3338748__F1 High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism 4763 3265 9456 85358 22941 8831 5894 5728 5163 5164 7249 7248 2475 6009 1977 7337 23237 PMC3339861__F4 EGF decreases free fatty acid (FFA) biosynthesis transcripts 55301 2194 1950 51144 9524 PMC3340361__F1 RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans 171013 867 2885 1950 1956 PMC3342067__F4 CD44 potentiates T cell activation, expansion, contraction, and maintenance of memory cells 324 3932 960 355 3575 841 7535 940 969 PMC3342370__F1 Role of autophagy during innate immunity 3553 9474 9140 PMC3345192__F1a MYC on the Path to Cancer 2932 1499 4609 4149 PMC3346900__F4 (A, B) Schematic view of the Fas/Fas-ligand (FasL) apoptotic signaling pathway 2021 355 581 637 27429 PMC3348497__F1 Insulin-like growth factor (IGF)-1 signal transduction 3479 3480 3667 PMC3351347__F7 Control of Pax3 expression in the caudal neurectoderm via NCE2 8463 1499 5077 6469 PMC3353643__F6 Proposed model of WNK4 signaling pathway mediating NCC regulation in DCT 1638 65125 130497 65266 6446 PMC3355932__F2 Anaplastic lymphoma kinase signaling 238 3717 6714 3718 2932 2353 2475 572 PMC3357548__F3 TWEAK signaling pathway: illustration of the TWEAK signaling pathway as visualized in NetSlim web page 7124 8742 140805 8772 208 2580 1147 831 100188835 5970 3725 5971 6347 PMC3359833__F2 Linking pathways to disease: Crohn's disease (from Wang et al 3594 3595 149233 3717 7297 6774 6775 6095 30009 8807 1234 1235 2833 PMC3360921__F8 IQGAP1 regulates cell homeostasis through mTORC1 1950 998 2475 207 8826 PMC3362922__F1 Hexosamine biosynthetic pathway and its dependent processes 5238 6675 8473 7536 100188011 6611 PMC3364444__F1 N-BPs may modulate myeloma progression through their effects on the mevalonate pathway and directly on MM plasma cells, bone marrow cells and immune cells in the bone marrow 6010 3479 7124 PMC3365728__F9 RANKL-induced actin ring organization in mature OCs 59341 6850 7189 6714 PMC3365799__F13 Major steroidogenic pathways in the three zones of the human adrenal cortex 5447 6822 9060 PMC3367861__F1 IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis 3716 3718 5921 998 2308 27086 5058 2551 PMC3370667__F1 Schema of the FUS1 pathway 1950 1956 4193 581 317 842 PMC3372250__F5 The Hsp90 folding cycle 11140 6491 5538 PMC3376391__F2 Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease 7808 847 9817 57716 PMC3376449__F1 HER2 signaling pathway 1378 1380 6774 6714 5728 2475 PMC3380218__F1 The Drosophila IMD and mammalian TNF signalling pathways 7186 23118 8717 8772 5966 841 5970 PMC3380518__F1 IL-33 signalling pathways 90865 6761 59307 4615 3654 51135 PMC3381865__F6 Proposed model for the role of the IGF-1R/NFKB signaling pathway in regulating the caspase-3 differentiation initiation signal 581 572 3480 331 PMC3382127__F7 Toll-Like Receptor 3 and Suppressor of Cytokine Signaling Proteins Regulate CXCR4 and CXCR7 Expression in Bone Marrow-Derived Human Multipotent Stromal Cells 7852 9021 3717 6772 8651 3659 7098 PMC3382204__F7 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease 2149 7035 2152 1361 2159 2147 2153 2158 2157 7450 7056 5624 2 5627 5327 5329 5328 2161 5340 966 718 729 735 1431 717 1380 PMC3382223__F2 Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes 8744 3592 50604 4790 2920 6347 8767 PMC3382223__F3 Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes transduced with Ad-Slug 29760 10544 6362 6869 6776 50604 5345 PMC3384380__F2 Schematic depiction of NFKB signaling pathway highlighting FOXP1 target genes 1950 4803 4049 958 4055 114609 7186 3932 7535 7334 5336 84433 10892 4791 2932 3065 3066 PMC3386597__F3 AML Signalisome 406934 6181 845 83871 2197 4628 84255 2113 1058 7171 114991 4774 6722 10127 1912 3064 60468 2671 7157 159296 8850 196 83463 5469 4232 444 4613 375449 8728 5008 3181 6695 7798 6230 4313 84733 3200 4094 6645 8544 23401 50862 30811 6095 55250 54822 3948 5064 64919 23269 2327 10020 81035 PMC3387654__F1 Mammalian Hippo pathway and cancer 4771 4485 9113 26524 PMC3388569__F3 Common biological pathways activated in OVCA cells in response to chemotherapeutic agents 324 10133 6418 572 3265 126669 5979 4117 PMC3390257__F2 mTOR: from growth signal integration to cancer, diabetes and ageing 5728 3667 5163 2932 7248 7249 6009 1975 27244 83667 7528 PMC3392447__F2 Routes of AMPAR trafficking 4905 23426 9463 547 PMC3395736__F1 Glycolytic pathway and its metabolic interconnection with the pentose-phosphate pathway 2539 8277 2597 PMC3397482__F2 Map of the VEGF signaling pathway (as an example of an important target in cancer therapy) obtained from KEGG is shown 4513 6714 572 PMC3398046__F5 MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Treatment with Steroids and Relationship with mRNA Targets 64499 7130 7159 64092 7035 3937 7763 715 257397 2683 8780 8887 51094 26994 3851 64108 4646 PMC3398478__F1 MAPK Pathways in S 11043 998 50964 7018 PMC3401455__F1 Models for the repair of DNA double-strand breaks 5888 5893 118027463 PMC3401681__F3 Mesenchymal stem cells (MSCs) may have both growth inhibitory and stimulatory effects on tumours 9242 6774 3569 PMC3403107__F8 The molecular pathway regulating Xenopus lung development 130497 116039 652 6657 7482 7472 6440 PMC3404840__F1 HIV pathogenesis and T-cell signaling by HIV-1 Nef 920 355 7852 1234 8772 1616 8717 7185 7186 PMC3405855__F5 Models of apoptosis-induced proliferation in mammals 8772 2353 1958 1356 PMC3406705__F8 Hypothetical model elucidating the regulation of phosphorylated FAK expression through an integrin A5 and B1-mediated MEK-ERK1/2-dependent pathway after ESWT 1499 3678 3688 PMC3410018__F5 Immune cell types implied to be involved in celiac disease by pathway analyses 324 355 356 23308 29851 5796 6774 10019 5771 8807 1493 3458 941 3553 1232 PMC3410226__F1 Insulin signaling pathway 5167 1401 57761 23239 PMC3411916__F3 [LM5]Strategies for treatment of traumatic central nervous system (CNS) injuries 2475 5728 7248 7249 9021 PMC3412587__F1 Ras signaling pathway which is disrupted in juvenile myelomonocytic leukemia (JMML) 6654 2885 867 4763 171023 PMC3412625__F6 Combination therapy with VELCADE and tPA is neuroprotective in aged rats after stroke and targets miRNA-146a and the toll-like receptor signaling pathway 7099 7097 3654 4318 3383 PMC3412972__F2 Proteins and protein isoforms in glycolysis/gluconeogenesis, TCA cycle, pentose phosphate pathway, galactose metabolism, and glutamine metabolism pathways 6120 130589 5226 7086 22934 2585 55276 3101 2645 57818 2539 2592 2582 5211 2203 5213 8789 5214 226 230 229 1431 260402 2023 50 6723 2271 3421 8801 2744 1743 3939 1738 3945 5106 PMC3416606__F1 Central carbon metabolism in S 2819 6886 2820 5230 2026 2023 100996949 5131 622 4190 48 50 4191 3417 3418 PMC3417062__F7 Molecular mechanisms underlying PA and histologically anaplastic PA 1956 4763 673 5728 5894 PMC3421055__F3 IMPACT OF ALTERED METHYLATION IN CYTOKINE SIGNALING AND PROTEASOME FUNCTION IN ALCOHOL AND VIRAL-MEDIATED DISEASES 635 27232 10400 4397 5091 PMC3425519__F2 Intracellular vascular endothelial growth factor (VEGF) signal transduction pathway 2885 5728 673 2475 PMC3425953__F3 The activity of PI3K signaling pathway in normal and tumor cells 1956 5728 2475 PMC3426835__F5 Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis 351 1020 348 PMC3427417__F7 Nicotine-induced A7nAChR/JAK2 pathway in cooperation with nicotine-mediated ERK1/2 activation potentiates STAT3 activation in PC cells 5091 1431 4585 3717 6774 PMC3428061__F2 Interface between hemostasis and adaptive immunity 5196 2833 2638 958 8877 7018 7054 5340 1901 PMC3428335__F8 Master Regulators in the Metabolic/Transcriptional Coupling in Breast Carcinomas 3157 1717 3156 4598 50814 10654 4597 7108 2224 1595 9453 2222 4047 6713 PMC3428377__F3 Signaling pathways for estrogen production and action 3727 3725 5266 7481 134 PMC3430210__F1 TRAIL signaling pathway and mechanisms of TRAIL resistance 8772 637 581 331 PMC3431500__F1 Class I PI3K signal transduction pathway 5728 5163 7249 7248 6009 PMC3432348__F1 Pathways activating and inhibiting complement 718 717 721 730 729 735 1378 966 PMC3432650__F1 How does Lin28 let-7 control development and disease? 389421 54487 79727 29102 100187761 PMC3433902__F5 Immune response to phagosome in antigen presentation network pathway map associated with the proteins identified as differentially regulated during zebrafish caudal fin regeneration 3929 1401 7448 367 1038 923 1399 27040 29760 3055 2268 9844 2885 5898 2923 847 5058 387 972 382 9475 7408 9478 23471 PMC3436816__F2 EnrichNet: network-based gene set enrichment analysis 50604 116379 2321 5516 50616 5515 196 1956 2735 23513 999 1380 4771 324 613 5728 5925 7175 5008 5979 7248 2956 120892 4640 9562 PMC3436837__F1 Boolean network model of the HGF-induced keratinocyte migration 3082 1956 5728 4319 54115 9846 5340 9590 998 5879 6364 1839 1386 1017 PMC3437636__F2 Formation of the NFKB-stimulating TNFR1 signaling complex 8717 8772 7186 PMC3442981__F1 Metabolic pathways for 2,3-butanediol biosynthesis and pyruvate metabolism in S 2819 2820 622 PMC3443185__F1 Two mechanisms underlying circadian control of NFKB response 8864 1408 1407 9575 406 PMC3448682__F7 Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis 7127 10906 4210 958 115361 3456 5292 3601 4938 4939 9246 PMC3449280__F1 An engineered eukaryotic protein glycosylation pathway in Escherichia coli 79868 56052 51390 PMC3457991__F3 Systematic Analysis of microRNA Targeting Impacted by Small Insertions and Deletions in Human Genome 407008 572 842 1950 3716 759 2744 4089 675 PMC3460045__F3 Pathological functions of LOX family oxidases during cancer progression and metastasis 1398 2932 4015 7422 3091 PMC3461241__F3 Network analysis suggests an immune response and inflammation in ulcerative tissue and non-ulcerative tissue of patients with ulcerative interstitial cystitis (IC) 695 5602 4067 5335 3937 4690 27040 2885 4893 867 868 2932 6850 4615 7294 6375 958 5606 3665 3702 7409 9641 2185 7124 353376 3455 3112 5879 1508 1520 3111 4688 PMC3461631__F2 Signaling cascades mediated by plexin-A and plexin-B, and their crosstalk with oncogenic pathways in gliomas 2064 2534 5728 5879 PMC3462113__F1 Main metabolic reactions in central carbon metabolism.A) Xylose can be assimilated through two pathways: the fungal oxidoreductive pathway consisting of XR and XDH or the bacterial isomerization pathway via an XI 6120 2752 5132 11113 7300 5091 4191 PMC3464266__F3 Insights into Pancreatic Cancer Etiology from Pathway Analysis of Genome-Wide Association Study Data 79290 9002 10316 26531 26188 138803 2565 442194 284532 887 1142 286362 4986 26533 1909 1133 138805 1902 121130 91807 5594 10000 3001 50674 PMC3464734__F2 Pre-treatment expression of TLR, RIG-I and IFN-beta pathway genes compared between the two patient groups 3456 7099 51284 54106 64135 7084 114609 4615 81030 57506 51135 9021 7187 5295 7189 3654 3550 9641 6773 1432 5599 4792 10379 3661 3665 3725 1386 4938 3669 91543 9636 8743 5610 3627 PMC3465072__F1 Crowdsourcing Network Inference: The DREAM Predictive Signaling Network Challenge 3479 7039 1956 2885 3667 7186 7189 5163 4214 5894 PMC3465331__F6 In Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow 55003 472 545 4193 4089 4088 4149 3084 6839 1719 5111 PMC3466049__F1 Complement-targeted therapeutics in periodontitis 727 929 7852 7099 5879 7096 7097 3659 2932 3458 PMC3472468__F4 Effects of sleep deprivation on the insulin signaling pathway 3643 8835 23265 2872 2002 7248 7249 2353 2308 3164 2475 5510 5507 648791 5502 6009 6720 1977 PMC3473263__F4 Sample regulation summary diagrams for E 54826 1401 1356 PMC3479343__F7 Placental PPARG Regulates Spatiotemporally Diverse Genes And A Unique Metabolic Network 79877 8694 3945 7038 PMC3480664__F1 Neurotrophin Regulation of Energy Balance in the Adult CNS and PNS 1392 627 4852 5443 181 23237 1270 PMC3482543__F7 Toll-Like Receptor 2-Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice 387 7099 7124 7097 PMC3482945__F3 Pathway related to prostate cancer 4129 6723 5034 8639 4942 2628 64087 9650 2235 4752 8525 25849 79602 5256 64595 2810 11257 140901 PMC3489622__F2 Signaling networks induced in the spleen at 1 day post infection in wild-type mice (A) and STAT1 KO mice (B) 9232 7422 9531 2634 5590 3661 5618 3659 10379 4599 3665 6773 103 5721 2633 10581 3455 4939 9915 PMC3490020__F1 The main MicroRNA biosynthetic pathway 29102 27161 26523 PMC3492042__F3 MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains 545 4661 993 7465 PMC3492042__F5 MicroRNA targetome suggests aberrant upregulation of T cell receptor signaling pathway molecules in ATL cells 3932 867 2534 27040 3702 1610 2885 PMC3494084__F4 Baculovirus infection impact on host cell metabolism 1431 11113 4118 PMC3494542__F3 TGFB non-canonical signaling pathway 1499 998 5879 387 PMC3496019__F2 Regulation of CSCs by inflammatory cytokine networks 3577 3579 6774 5728 648 5970 595 PMC3499189__F2 Synopsis of major pathways activating mTORC1 3479 27040 3480 3667 7249 7248 6009 PMC3500863__F3 Pathways regulating NEKs in cell cycle control 5347 983 4751 545 472 5894 152110 91754 10783 140609 79858 993 PMC3501207__F1 Cholesterol Accumulation Regulates the Expression of Macrophage Proteins Implicated In Proteolysis and Complement Activation 2885 387 3479 7534 2147 2335 929 5199 3684 4282 3075 718 3557 712 3326 348 713 6696 3107 PMC3502657__F1 Signaling pathways for longevity 3479 6009 5728 5163 253260 208 207 6446 PMC3502657__F2 Signaling pathways for longevity 407043 65095 889 5728 10915 PMC3502714__F2 Fibroblast growth factor 23: State of the field and future directions 8074 9368 5741 5045 2591 2260 PMC3504424__F3 Canonical Wnt-Beta-catenin pathway 1499 2932 324 PMC3504424__F5 Transforming growth factorB (TGFB) pathway 4087 4088 4089 PMC3507315__F2 T cell receptor signaling pathway extracted from BioCarta database 7535 27040 5327 2534 2885 3725 PMC3507315__F3 Fc epsilon receptor I signaling in mast cell pathway extracted from BioCarta database 2885 4067 6850 695 2002 PMC3507315__F9 mTOR signaling pathway extracted from KEGG database 2475 253260 7249 6009 1977 673 PMC3509664__F8 PKR, ISG15 as modulators of IFN induction during HCV infection 83939 100187761 7187 57506 7706 9636 3661 PMC3511325__F9 Protective Role of STAT3 in NMDA and Glutamate-Induced Neuronal Death: Negative Regulatory Effect of SOCS3 3569 3717 3716 581 9021 6774 PMC3512134__F6 Overall organization of mitotic exit control 324 991 999 PMC3514894__F1 Interplay between Smoking-induced Genotoxicity and Altered Signaling in Pancreatic Carcinogenesis 5053 1950 1956 4318 999 3845 2638 23464 64403 1000 596 331 3725 2353 4609 6774 3717 PMC3515033__F2 Classification of Toll-like receptors (TLRs) 7100 7096 7097 10333 7099 7098 51284 51311 54106 4615 7124 3458 5066 4118 PMC3518557__F1 Targets and structure of compstatin 1356 716 718 7938 PMC3520542__F13 Molecular mechanism for Elovl5 control of mTORC2, FoxO1-S256 phosphorylation, and hepatic GNG 9415 3992 54898 60481 253260 2194 79071 5105 PMC3521791__F6 Part of the top canonical pathway affected by in vivo LPS administration into the human lung 3929 929 54106 51284 7099 960 7100 9173 7098 10333 51311 81793 114609 695 7097 7096 54476 2314 4615 23471 353376 54472 3654 51135 3656 11213 91662 5291 10906 7189 7128 9618 4214 148022 79931 8737 5604 5605 5606 5609 6416 7187 5608 1796 9046 1432 8651 5594 5970 4790 1843 5595 5901 3665 3661 10392 64127 1385 3725 602 2002 PMC3524013__F3 Full network comparison of the original canonical pathway and the inferred cell-type-specific pathway 7039 3479 3552 1956 3667 7186 2885 6885 4214 5163 5894 PMC3524194__F1 Upstream regulators of the Hippo pathway 4018 6010 4485 60485 9113 PMC3526508__F2 Becoming a follicular or a MZ B-cell? 613 4853 695 PMC3527239__F2 Metabolic pathways of TAG synthesis and degradation and their subcellular localization (adapted from and ) 3630 4099 1040 84706 9162 2195 26136 1632 2237 95 25913 PMC3528378__F3 Mechanism of muscle protein synthesis inhibition by GCs 3479 5163 2475 1977 PMC3530555__F5 Combined Inhibition of IGF-1R/IR and Src Family Kinases Enhances Antitumor Effects in Prostate Cancer by Decreasing Activated Survival Pathways 3479 3480 208 207 PMC3532179__F1 Mathematical model of the apoptotic pathways induced by cisplatin 581 545 842 836 PMC3532605__F7 NFKB signalling pathway 2321 1950 7049 4803 7039 4049 7098 81793 958 100187907 114609 7535 5336 5970 5971 4151 PMC3534598__F1 Cartoon depicting the role of sialidases during the multistep process of myogenesis 4759 1956 10825 4758 4280 100187761 PMC3534995__F2 Canonical pathway representing LPS/IL-1-mediated inhibition of RXR function obtained by IPA from the analysis of HT29 data set 3929 7099 929 9060 1555 6649 PMC3534995__F3 Canonical pathway representing NRF2-mediated oxidative stress response obtained by IPA from the analysis of SW480 data set 4214 6885 4217 5894 5604 5607 207 5598 1432 2932 9451 9817 9978 8452 468 3725 4094 8061 9709 2052 2729 847 PMC3539742__F2 Autophagy and apoptosis- what’s the connection? 637 355 836 841 8772 1611 3725 PMC3539919__F2 Simplified carbon metabolic network 7167 5230 4190 2026 PMC3542205__F5 Illustration of the expression levels of enzymes within the glycolytic pathway and major connections in the C 2597 5230 5232 5236 55276 5238 5132 PMC3542954__F1 Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosisEBV infection disrupts normal cell death and survival pathways in various human tumor cells, including lymphocytes, fibroblasts, and epithelial cells 613 972 3458 355 637 596 PMC3547902__F2 Autocrine functions of VEGF in breast tumor cells 8829 10371 8828 51665 PMC3548977__F1 Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists 6608 2736 2735 64399 596 4609 3481 PMC3549334__F7 Ras activation by •NO-mediated processes in pancreatic cancer 5898 5899 3265 PMC3551337__F2 Major pathogenic lesions in MCL 613 5728 6850 7187 7186 5163 7249 5971 595 1017 4193 472 PMC3551337__F3 CRM1 regulates the PI3K signaling pathway in MCL 613 6850 695 5163 5728 1017 1869 PMC3552454__F4 Advances in graft-versus-host disease biology and therapy 325 324 4615 64127 7124 6772 PMC3554567__F4 Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry 8928 4838 4089 PMC3559989__F6 Bayesian regulatory network and optimal regulatory pathway of p42.3 protein 7428 6282 6667 6093 6275 5728 6010 PMC3561661__F1 Activation and function of PI3K/Akt signaling in CD8 T cell 324 5728 5163 940 7249 7248 1499 6009 3575 10365 51176 8320 4609 PMC3562293__F2 Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities 4023 5091 6010 4018 5879 2475 PMC3565070__F3 Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections 4353 4025 3170 2920 2919 2921 11009 1956 1839 4583 727897 7852 3383 7850 1843 1649 6648 3162 1080 PMC3565216__F1 Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae 84706 1040 3630 84249 5091 PMC3568227__F2 Role of mesothelin in cancer progressionOverexpression of mesothelin leads to higher IL-6 production by constitutively activating NFKB 10232 6774 572 581 1017 PMC3568707__F1 BiP as master regulator of the Unfolded Protein Response 22926 83939 468 7494 PMC3570203__F2 Genes highly expressed in TNBC compared to HR-positive, HER2-negative breast cancer 5268 4321 2597 2950 7277 1381 4133 7298 7153 5347 7272 1111 9212 699 1058 991 1062 55635 10403 10460 4288 3833 22974 1063 9232 11004 4605 2305 PMC3571341__F12 Proposed model of M-CSF-mediated organization of the osteoclast cytoskeleton 2695 6850 10451 PMC3571654__F1 shows the effects of osteoblast-secreted osteocalcin on glucose homeostasis and its novel role in regulating testosterone production in the leydig cells 860 468 1583 6770 PMC3575449__F1 From photomorphogenesis to cancer 64326 1447 1448 4193 6502 PMC3576882__F4 NFKB: Roles and Regulation In Different CD4+ T cell subsets 942 941 940 5163 8915 10892 2475 PMC3577904__F3 Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice 844 58 4879 84525 2353 6722 1958 2274 1827 2273 7169 PMC3579607__F1 Mechanisms underlying HER2-directed therapy cardiotoxicity 2064 2066 2065 3084 6714 5163 2475 2626 PMC3579607__F2 Mechanisms underlying modulation of HER2-directed therapy cardiotoxicity through aerobic exercise 2064 2066 2065 3084 6714 5163 2475 2626 PMC3582569__F2 Pathways regulated or induced by the presence of a specific sugar 2582 4668 2592 51083 101448070 7504 2353 22934 2597 2023 PMC3583293__F7 Model depicting how Shh promotes CGNP proliferation through combined effects on Gli1/2 and the mTOR pathway components eIF4E and S6K 6469 6608 3667 1977 2735 2736 PMC3583555__F1 Simple model for regulation of breast cancer initiating cells (BT-IC) self-renewal in breast cancer 6608 51684 648 PMC3584002__F7 Model for GPN1, 2, and 3 function in biogenesis of RNA polymerases II and III 11321 51184 54707 907 PMC3587990__F1 Scheme of PI3K/AKT mediated antiapoptotic regulations at the mitochondria 2475 581 572 331 PMC3587990__F2 Scheme of survival signaling cascade by receptor tyrosine kinases via PI3K/AKT mediated survival 5728 5164 4193 2475 572 PMC3587990__F3 Pathway of apoptosis 581 572 596 637 331 PMC3587990__F4 Interaction of marine compounds on survival and apoptotic signaling molecules 2475 581 572 331 PMC3588029__F3 Regulation of PGC-1A—this schematic represents the relationship between nutrition, circadian clock and other regulatory factors involved in post-translational modification of PGC-1A and its consequent impact on metabolic genes and aging 9575 10135 7528 23411 2932 PMC3588076__F3 Regulatory networks of mTOR inhibitors and miRNAs in controlling the mTOR pathway in cancer 3480 5728 5163 7249 7248 1999 8408 1977 PMC3589543__F7 A pathway choice model for repair of a DNA DSB in Arabidopsis 3981 23137 79677 PMC3589553__F3 Regulatory mechanisms for the Hippo pathway 64398 10207 154796 5784 351 4485 84962 9113 23513 3535 6010 PMC3594938__F5 Cell type-specific outcomes of KSHV interactions with CD36 and CD147 signaling pathways 948 2534 4067 2475 PMC3596735__F3 ERK/MEK pathway 2886 3717 2885 1398 2534 22808 998 1793 6009 2212 3932 5590 4342 2065 7444 572 1977 2002 6722 3845 PMC3597489__F4 Conjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring 5934 246751 10468 4838 93 PMC3598692__F8 Toll-like receptor signaling pathway figure supplied by KEGG ] 7124 54472 100379198 8772 3569 114609 929 27152 100187907 7189 920 1513 PMC3599046__F1 JAK/STAT signaling pathway in response to MDV infection 2056 8027 5300 PMC3599046__F2 Toll-like receptor signaling pathway in response to MDV infection 7089 8772 114609 3929 929 23118 7189 8178 1513 PMC3600829__F4 Functional analysis of the gene expression networks, performed using Ingenuity Pathway Analysis (IPA) 9332 2322 6777 6776 3458 11213 3560 4734 2887 92610 3738 7049 5004 3934 1378 54941 8778 PMC3603375__F4 Neurotrophin signaling pathway is among the pathways downregulated in clinical T1 and upregulated in clinical T2 4803 2549 5179 PMC3603396__F3 Altered colonic metabolites during conventionalisation 7054 9615 230 4351 10667 1757 80055 51083 6401 440 5901 790 3034 7939 PMC3604104__F5 Gene Expression Networks Underlying Ovarian Development in Wild Largemouth Bass (Micropterus salmoides) 2335 5170 207 2932 1499 PMC3606085__F4 NER pathway 8452 5810 5111 PMC3606104__F3 Identification of genetic networks that regulate the induction of filamentous growth 84188 23595 999 4171 5000 2739 27010 10519 375757 699 996 991 9184 PMC3607645__F5 Epidermis model pathways 130497 1957 65125 1612 PMC3607786__F1 MTOR signal pathway in autism spectrum disorders 6259 5728 7248 6009 7249 1977 PMC3608394__F5 Subnetworks identified from TCGA ovarian cancer gene expression data set 4893 2786 351 5925 1760 6714 7529 1387 4137 672 3955 6790 5888 4609 6908 4149 PMC3608394__F6 Enriched pathways and GO functional annotations are: (a) ErbB signaling pathway: p=9.10e-13; Signal transduction p=2.33e-07 285 3630 7057 182 3643 7010 2886 1956 4851 4854 4853 7529 25970 6464 23509 4242 5664 5753 6714 3717 5515 22938 PMC3610211__F1 TSC/mTORC1 signaling pathway at the neuronal synapse 5728 4763 7249 7248 5066 6009 200933 2475 1977 PMC3614663__F1 Diagram showing the crosstalk between the DNA damage response pathway and BMP-controlled osterix expression and osteoblast differentiation 4086 4089 472 4193 993 PMC3614848__F2 STRING interaction for proteins studied to find relevant networks in RCC 6517 6513 768 3791 3091 7428 7422 6515 4193 596 581 6514 6518 332 PMC3616892__F6 MTOR in CD4+ T cell differentiation 6775 6774 9021 50943 9655 6778 2625 920 PMC3620110__F2 Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß 10551 4086 4147 10468 6876 7045 4739 51523 2736 3624 50807 7247 8470 4162 2625 PMC3621013__F5 Control of Alternative Splicing in Immune Responses: Many Regulators, Many Predictions, Much Still to Learn 10922 92906 10659 960 51176 PMC3626710__F5 Results from single pathway sets 383 2203 7167 384 252842 252843 5236 5108 873 2592 55276 5238 2549 683 PMC3626841__F4 Original model by Neumann et al 8772 836 841 PMC3632219__F7 Proposed roles of PLCB1 in degradation of endocannabinoids at implantation sites 2166 23236 4513 PMC3632418__F1 mTOR as a potential treatment target for epilepsy 92335 5728 7248 7249 6009 1977 PMC3633842__F5 Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns 8743 4940 8638 51191 3437 2635 4939 91543 3433 3434 3665 6772 6773 103 4599 64135 PMC3634451__F2 FGF signalling cascade in Drosophila melanogaster 2885 998 2695 999 PMC3634610__F2 Signaling network of Dectin-1 5336 6850 64170 8915 10892 5971 114548 PMC3634610__F3 ITAM-like-bearing CTLRs within the Dectin-1 cluster 283420 6850 5336 7124 PMC3634825__F3 Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes 586 587 593 594 1738 1629 34 36 35 3712 27034 1892 1962 3030 64087 56922 3028 26275 3033 549 38 3157 3158 39 10449 11112 3155 30 3032 4329 18 5019 217 64064 219 5095 223 316 5096 224 501 84693 PMC3634910__F1 Nutrient Signaling to mTOR and Cell Growth 5728 2885 5163 4763 7249 51256 7248 6009 PMC3635745__F1 Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways 5728 930 975 974 6850 695 4067 1445 2534 26191 933 971 55024 640 PMC3635988__F12 HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1 4615 3654 3665 3454 3455 PMC3637685__F2 GAIT-mediated translational control 4553 1999 1977 2597 PMC3638038__F1 Pluripotent Stem Cells: Immune to the Immune system? 324 920 1493 941 942 940 9308 50943 PMC3638243__F8 The plasminogen (Plg)-dependent pathway of foam cell formation 5340 948 968 19 1051 5284 PMC3648790__F4 Interplay Between the Cancer Genome and Epigenome 2146 7403 3417 3418 3720 5931 5928 8314 9055 23492 55252 PMC3651593__F1 Pathway of Fbw7-mediated degradation 7316 9978 8454 6500 PMC3651771__F1 Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1RAvB3 integrin complex in tumorigenesis and angiogenesis 6382 3479 3480 PMC3652739__F4 Microarray analysis also indicated an increase in Wnt signaling and cell cycle regulation in women 4609 1719 5111 PMC3653120__F3 Effect of cigarette smoke on the etiology of colon carcinogenesis 673 3845 1956 PMC3653888__F3 Yin Yang 1 and Adipogenic Gene Network Expression in Longissimus Muscle of Beef Cattle in Response to Nutritional Management 7528 6777 3458 2959 3488 8850 7421 6257 5468 2022 PMC3653888__F4 Summary of YY1 gene network expression in steers comparing early weaning (EWS) against normal weaning without creep feeding (NWN) at 240 days on treatment.Notes: Cellular locations depicted are from the Ingenuity Pathway Analysis® knowledge base 3488 11201 6777 7528 8850 5468 7421 6257 PMC3654365__F5 Summary of the metabolic pathways in which the metabolites described in this paper are involved 11113 1636 5212 PMC3661399__F7 Selected AMPK and IGF-IR signalling pathways relevant to this study in normal (A) and hyperglycaemic (B) conditions 3667 7249 2475 PMC3666258__F5 Diagram of norrin as a multifunctional ligand for three receptors/binding proteins 55366 6104 650 652 PMC3666582__F7 IDENTIFICATION AND DESCRIPTION OF A NOVEL MURINE MODEL FOR POLYTRAUMA AND SHOCK 3929 7189 7297 6774 3162 PMC3667790__F7 DSG3 Facilitates Cancer Cell Growth and Invasion through the DSG3-Plakoglobin-TCF/LEF-Myc/Cyclin D1/MMP Signaling Pathway 1830 595 4316 PMC3669661__F1 Phosphatidic Acid and Lipid Sensing by mTOR 2475 5728 5163 7249 7248 6009 PMC3669661__F2 Phosphatidic Acid and Lipid Sensing by mTOR 4018 95 5091 PMC3670175__F1 Quantitative proteomics by amino acid labeling identifies novel NHR-49 regulated proteins in C. elegans 51 2195 2196 PMC3671288__F2 Inhibitory pathway of PGE2 in effector T cells 50943 920 3932 1445 PMC3672537__F2 Postulated interaction between the insulin signaling pathway and activation of the pro-inflammatory cascade in the pathogenesis of insulin resistance in sepsis 3929 7099 929 3667 7124 PMC3675167__F8 Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol 4615 58484 114548 3553 PMC3675380__F2 Synergy between TCR/CD28 and TNFR signalosomes for activation of the PI3K-Akt pathway in T cells 324 941 942 940 5163 8915 10892 2932 PMC3676391__F1 Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling 51094 5008 26060 PMC3676754__F2a The Brassinosteroid Signaling Pathway—New Key Players and Interconnections with Other Signaling Networks Crucial for Plant Development and Stress Tolerance 1283 51411 4431 578 PMC3678415__F2 HDL biogenesis 3931 19 9619 PMC3680752__F10 A: the top-associated network as defined by Ingenuity Pathway Analysis (IPA) for NAc mRNAs upregulated in HVRs vs 6919 402 2099 64761 93663 PMC3680918__F6 Schematic diagram of the PIP signaling pathway in ER-negative breast cancer 3688 2064 1385 PMC3681733__F2 Reprogramming Neutral Lipid Metabolism in Mouse Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes 23646 5091 3991 4099 4247 4245 4018 3988 51099 8694 PMC3683958__F3 The dynamic regulation of NAD metabolism in mitochondria 10135 203447 4860 PMC3684083__F1 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets 7039 1950 1956 2691 673 2475 PMC3684083__F2 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets 650 7046 673 4087 4088 4089 2475 PMC3688869__F5 Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer 1630 4087 324 4436 406991 572 842 836 4397 581 PMC3689575__F1 Modeling the genetic basis for human sleep disorders in Drosophila 3930 5898 367 81693 3550 10761 5962 5966 PMC3689941__F9 STAT3 pathway switching is induced by EMT during breast cancer progression 1956 6714 3717 6774 PMC3690520__F3 TCR signaling pathway leading to NFKB and JNK activation 324 5163 10892 940 8915 PMC3690588__F1 Wnt signaling 1499 6010 324 607 PMC3691184__F5 Integrated miRNA-mRNA Analysis Revealing the Potential Roles of miRNAs in Chordomas 5228 2316 7124 7186 355 4149 4208 51701 PMC3691869__F6 Schematic outline of the regulation of EGFR internalization and mediated signaling by the CIN85–SH3GL2–Cbl complex 1950 1956 6774 6456 1499 PMC3693462__F1 BRCA1: A Missing Link in the Fanconi Anemia/BRCA Pathway 199990 7398 80233 675 79728 672 5889 PMC3693466__F1 Insulin Signaling: Inositol Phosphates Get Into the Akt 3667 5163 5728 9807 5266 PMC3693544__F2 Transcriptional feedback in the insulin signalling pathway modulates ageing 4018 1499 5728 7248 5163 6009 717 253260 207 29904 23235 5225 PMC3694398__F5 NFAT Gene Family in Inflammation and Cancer 4772 1499 3589 3565 100379198 6423 4513 PMC3694812__F1 Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data 3084 9542 998 27010 PMC3694812__F4 Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data 998 3084 9542 7168 27010 PMC3696998__F9 Comparison of CK2 knockout defects and Wnt pathway knockout defects, with a schema to indicate where in the pathway CK2 is believed to act 1499 51176 26278 PMC3699421__F2 Reactivation of HIV-1 transcriptional latency 2146 6839 10614 PMC3701722__F1 Autophagy and endocrine resistance in breast cancer 2475 8408 9776 9474 9140 PMC3703460__F4 Signaling Pathways That Control mRNA Turnover 5163 29102 54487 PMC3704444__F1 Interaction between quality control systems for ER protein folding and RNA biogenesis 100187761 23293 9887 23049 5976 26019 22926 83939 1998 22894 51010 PMC3705993__F1 LRP5, LRP6 and LRP4 are important components of the Wnt/Beta-catenin signaling pathway 4280 3042 22943 6422 4038 4040 1499 PMC3706794__F8 Proposed mechanism demonstrating the interplay of heme oxygenase 1 (HO-1) and the Wnt canonical pathway in the modulation of adipogenesis in mesenchymal stem cells (MSC)-derived adipocytes 9242 7480 1499 948 2932 PMC3710993__F1 Energy status of cells modulating cell signaling and mitochondrial function 5728 6009 7248 2932 PMC3711381__F1 ERK pathway, its upstream activators and downstream targets 627 1950 1956 5894 2002 PMC3712052__F1 Analysis strategy (–) to identify the putative regulatory effect of GWAS candidate () on FRMD3 regulation (), linking the gene to transcriptional regulation of the BMP pathway (–) and DN and suggesting a hypothetical regulatory model () 257019 6885 3845 331 PMC3713357__F1 Possible pathways for growth factor mediated tumorigenesis 759 5163 2475 PMC3718392__F2 Targeting of PI3K/mTORC1 signaling in hamartoma syndromes 5728 1431 7248 6009 7249 PMC3718700__F4 Presenilin functions 9924 351 1499 595 759 PMC3721034__F5 MDM2-p53 pathway revisited 6154 6045 4193 23429 133746 5371 28996 PMC3725164__F1 TGFB signaling pathway 4087 4088 6497 PMC3725543__F6 FAK-mediated growth of C2C12 cells in response to IGF-I 3479 7248 7249 2475 PMC3726942__F10 Roles of the autocrine angiotensin system in ER stress-induced apoptosis of alveolar epithelial cells 107988031 59272 183 545 PMC3729336__F1 Schematic overview of the kynurenine (KYN) pathway 169355 3620 8564 PMC3730428__F8 Schematic diagram summarizing the key findings 7124 8737 8717 7186 8772 841 836 331 840 PMC3730684__F1 The Smad-dependent TGFB signalling pathway upon stimulation with TGFB and BMP 5212 4087 4086 4089 6476 4092 PMC3731316__F1 Gene Network Analysis of Candidate Loci for Human Anorectal Malformations 84432 27121 85403 154810 8178 27152 51057 54361 51029 6659 1495 1016 55553 64374 PMC3732412__F3 KEGG pathway map for genes in the three modules 4089 3458 4091 4092 9978 8454 7057 6500 4052 7046 387 10468 5308 4838 PMC3733021__F1 Schematic diagram of the ZFN, TALEN, and CRISPR/Cas9 genome editing tools 324 201633 151888 3902 1796 9046 1445 PMC3733085__F2 Simplified scheme of the pathways of complement activation 718 715 716 2271 4179 1604 727 PMC3733962__F1 Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2A Expression 26586 5034 23677 7332 3930 9181 7532 9918 7159 7157 11214 5784 11315 6625 3329 81 10575 2539 6181 3313 PMC3734218__F1 Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis 6573 10599 9376 5243 2356 8836 1719 7298 2618 4522 4524 6470 4548 4552 5212 2950 7172 PMC3735826__F5 miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients 4087 5581 4306 6247 3066 2353 7422 7428 5728 112399 332 PMC3736482__F3 Associated intracellular cascades to physiopathology of vascular remodeling 1956 6714 3717 3479 7412 3383 PMC3738179__F1 Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling 6608 2638 5727 PMC3739039__F3 Integrated “omic” analysis reveals global metabolic changes 471 7372 7086 PMC3739442__F1 Accelerated aging model in HIV infection 920 23379 940 PMC3741150__F8 Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFA Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells 7019 54106 1889 PMC3742180__F8 Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles 7099 929 3929 PMC3742228__F2 Schematic overview of Hedgehog signaling and rationale for combination therapy with (chemo)radiotherapy 5091 4318 51684 2736 2737 2735 6469 5727 6608 5243 79923 9429 1499 472 PMC3742358__F3 Pathway of nucleotide excision repair and translesion synthesis 57654 56949 7507 5111 PMC3742550__F3 Intracellular 1-carbon metabolism (simplified), emphasizing pathways relevant to the text 1719 7298 2618 4552 4524 4548 1788 10768 4522 7054 PMC37430__F1 Simplified steps of Okazaki fragment maturation during DNA lagging strand synthesis (for further details see refs 1763 9156 5893 PMC3743157__F3 RB1 pathway indicating genes with mutations in this series 1029 1021 1019 6608 5727 51684 5925 2735 PMC3744088__F6 Extent to which glutamate (GLU) is oxidized in astrocytes seems to increase particularly during higher glutamate concentrations 5091 11113 4118 PMC3744771__F1 Inhibitory molecules and therapeutic targets within the Rhopathway 56963 4099 84894 2043 387 718 PMC3744802__F5 Model of regulation of the length of D-loop extension by PCNA and choice of polymerase 5111 353497 51426 PMC3747383__F1 PPARG transduction pathway 4513 1020 4023 10682 PMC3747619__F2 Key reactions involved in the sphingolipid metabolic pathway 2531 64781 7357 PMC3749695__F8 Cumulative scheme adapted from the data published in (, –, , , , , ) showing components of pathways implicated in regulating the life span in Drosophila and their interactions 57716 2539 9817 5728 7248 7249 6009 PMC3750403__F3 BIOBASE-derived signaling network centered on p38 MAPK 1385 2002 2235 7018 7099 4609 2309 64167 1912 63940 PMC3753703__F3 Alterations within the TP53 and RB1/E2F3 pathways in high-grade bladder cancer 4193 7157 595 5925 1871 898 PMC3753830__F1 Schematic overview of signalling pathways and drug targets currently under investigation in CML research 5371 240 6608 1499 2475 PMC3754249__F2 HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations 3939 5163 47 4118 50 48 3418 3417 664 665 PMC3754249__F3 HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations 2539 2821 84076 5223 3945 3939 PMC3756346__F2 Map of the molecular mechanisms of apoptosis 8717 637 572 355 843 8772 842 27429 56616 2021 4671 331 PMC3756375__F2 Nerve growth factor (NGF) signaling in breast cancer cells 4803 8717 84707 PMC3756614__F11 Signaling pathways used by EGF to stimulate goblet cell proliferation 1950 1956 2885 2549 6714 PMC3759480__F3 Wnt/Beta-catenin signaling was activated in gemcitabine resistant NSCLC cell lines 4193 4609 3725 960 6925 22943 PMC3759859__F2 Oncogenic role of the AKT signaling pathway 5163 5728 7249 7248 6009 2475 572 253260 4193 PMC3759859__F4 Interplay between p53 and AKT/mTOR in regulating autophagy 5728 7249 7248 9776 2475 6009 545 472 PMC3761221__F4 Fear learning and memory across adolescent development Hormones and Behavior Special Issue: Puberty and Adolescence 759 761 847 PMC3762125__F5 Synergy between RasGRP and SOS in TCR signaling 5335 27040 2885 2922 PMC3763710__F1 The p53 Pathway as a Target in Cancer Therapeutics: Obstacles and Promise 145270 23411 4193 581 PMC3769161__F7 Interleukin-17 Enhancement of the Interleukin-6 Signaling Cascade in Astrocytes 9021 920 3553 84818 PMC3772101__F1 Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway 6772 6773 10379 9282 9636 PMC3773501__F1 NOD2, an Intracellular Innate Immune Sensor Involved in Host Defense and Crohn's Disease 64127 55054 57506 3661 3662 PMC3774122__F2 NRF2-mediated oxidative stress response pathway 5584 7415 3162 2729 2512 6648 55735 131118 PMC3775123__F2 Signaling modules that are important therapeutic targets to counteract muscle wasting 3479 6446 3726 2475 4087 4088 3480 PMC3775430__F1 PI3K/PTEN/Akt pathway 5163 5728 367 2475 PMC3775637__F3 Targeting the PI3K and BTK pathways in NHL 6850 5728 7249 7248 695 6009 4193 4609 PMC3777479__F2 Niclosamide targets the Wnt/Beta-catenin, Notch, and mTORC1 pathways 3667 2932 1499 324 PMC3780793__F1 Genes identified in the phosphatidylinositol and hedgehog signaling pathways 3938 10423 5291 5305 8394 5728 113026 8760 4952 5298 5578 1609 1607 3633 5266 7546 652 54361 4036 2520 6608 51715 2932 1455 PMC3784162__F2 Toll-like receptor 3 (TLR3) participates in both defence and offence in host immunity to viruses 7098 7186 7187 7189 23118 3661 PMC3784453__F10 Leu452His Mutation in Lipoprotein Lipase Gene Transfer Associated with Hypertriglyceridemia in Mice in vivo 4023 7038 23411 5225 7351 PMC3784667__F2 Intracellular cycling of MUC1MUC1 is phosphorylated by EGFR and other receptor tyrosine kinases 1956 4582 6714 PMC3784815__F3 Kidney immune activation against ischemia-reperfusion and transplant injury 718 1431 324 PMC3787928__F2 Action of Smac mimetics.Notes: IAPs are important regulators of NFKB-activating signaling pathways 8717 7186 6611 10454 23118 8772 81858 5970 5971 331 3569 PMC3788359__F3 Pathways linking hypoxia to CSCs and EMT in tumor aggressiveness 3481 664 79923 6657 9839 PMC3792350__F1 Overview of peroxisome biogenesis: converging de novo and growth and division models 439 5824 8504 5190 5189 1759 PMC3794211__F2 MiRNAs implicated in neurodegeneration 120892 6622 3064 6908 351 5978 102 407022 2521 PMC3794591__F5 Pathway map of fatty acid metabolism 25913 1632 261727 6671 PMC3801100__F1 RSK isoforms control motility and other aspects of tumor cell invasion and metastasis 3725 6010 8682 7408 PMC3807098__F1 Squalene Synthase Inhibitor Lapaquistat Acetate: Could Anything Be Better Than Statins? 4553 387 5879 998 PMC3807240__F1 The NLRP3 inflammasome regulates the DNA damage response pathway 834 4968 331 330 PMC3808847__F1 Kisspeptin and Neurokinin B Pathway Deficiencies and Resulting Phenotypes in Mice and Men 3814 3549 4280 PMC3809585__F2 TAM receptor signaling pathways 8205 2885 1398 6772 8651 PMC3810594__F1 Renin-angiotensin-aldosterone system and regulation of insulin signaling phosphorylation of docking protein insulin receptor substrate -1 (IRS-1) is the major converging point in insulin signaling 3667 367 2475 PMC3814888__F5 Mitochondrial activity pathway 120892 65018 836 842 27429 PMC3819050__F2 Wnt7a signals bi-directionally at vertebrate synapses 1855 7476 7474 PMC3820435__F3 Cell death signaling by the ER stress response/UPR 22926 7186 83939 468 637 581 PMC3820656__F1 Scheme of the endothelial angiopoietin (Angpt)/Tie2 system highlighting fundamental signalling pathways 284 285 1003 5879 6010 PMC3821994__F1 PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory feedback loops 627 5163 6009 7249 7248 2475 253260 29904 1938 PMC3822533__F3 Unfolded protein response in mammalian cells 22926 7186 468 PMC3824607__F1 TNFAlpha-mediated transient IKK activation pathways 8717 7186 23118 10454 PMC3825194__F1 TGFB signaling through Smad-dependent and Smad-independent pathways 4087 4088 4091 4092 7189 6010 4089 7018 PMC3827118__F1 Wnt-dependent pathway responses 4041 4040 4920 324 1499 64840 PMC3829153__F8 Molecular mechanism of DSS-induced colitis in murine model 6469 64127 8650 27148 51684 3298 2736 5727 6608 PMC3829196__F2 The p53-mediated apoptotic signaling pathways 64065 355 545 472 581 317 PMC3829803__F7 Retinoid action during paramyxovirus infection 3454 3455 57506 3659 10379 3665 PMC3830198__F4 Model showing the proposed mechanisms of lncRNA-mediated regulation of the RB pathway 1021 1019 100033819 283120 PMC3830198__F5 Model showing the proposed mechanisms of lncRNA-mediated regulation of the p53 pathway 472 545 4193 PMC3834158__F4 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats 7038 54677 79071 2194 1431 5465 5468 PMC3834519__F10 FXR/NR1H4 gene 6374 10563 6387 6373 11213 79931 355 7124 9971 207 925 5594 1432 4318 3383 1234 920 2919 6347 PMC3836169__F1 PTEN in cancer, metabolism and aging 3479 3667 8660 64223 2308 2309 2152 PMC3838875__F4 Cancer Cells Incorporate and Remodel Exogenous Palmitate into Structural and Oncogenic Signaling Lipids 4018 5091 95 PMC3839643__F3 Enzymes that catabolize or use essential amino acids 5053 4843 383 157739 3034 3067 10157 587 586 1036 PMC3841209__F9 Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer 1956 3845 369 673 PMC3841791__F9 Predicted upstream regulators inhibited in DA rats but activated in congenics 3991 10062 5468 1051 8061 1050 1385 2308 1499 5970 3725 6667 7157 1026 1869 4792 4609 1958 5925 4088 185 2247 2099 860 PMC3845556__F1 Targeting the PI3K-AKT-mTOR signaling network in cancer 3479 3481 5728 7249 7248 6009 2475 PMC3852779__F2 Hepatic genes differentially regulated by 17Beta-trenbolone: Impacts on metabolic pathways 1588 1559 1565 1576 1535 6999 4151 5629 1794 4353 1536 8288 10858 114757 54205 1553 4842 1595 1591 1580 6391 1593 1537 PMC3854201__F4 Biological interaction networking of PSME1 and RPS12 in chronic atrophic gastritis (CAG) 8190 1103 4880 9641 673 5894 2022 5720 595 3106 3553 6194 7124 2153 6206 PMC3855094__F5 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects 2260 1956 238 6714 3702 3932 6774 673 7465 995 983 1019 1017 PMC3855094__F7 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects 238 1956 2260 6714 3702 3932 6774 673 995 7465 1019 983 1017 PMC3855094__F13 Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects 7039 3630 3082 3667 PMC3856587__F2 Genetic pathway predicted to regulate the interaction between 5-HT synthesis, transport and degradation and the stress response mediated by the HPA axis 627 1392 100170220 PMC3856587__F3 Simplified model of the regulatory interactions between the serotonin and stress response pathways mediated by the HPA axis 6571 4128 100170220 627 551 1392 PMC3857155__F1 Basic depiction of the classical view of the PI3K signaling network (black arrows) as well as the novel signaling pathway revealed in the study by Tan et al 5163 5728 2475 5347 4609 PMC3857640__F5 Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk 3718 3717 6774 PMC3858190__F4 Pathways involved in sensing and responding to double-stranded RNA and other pathogen-associated molecular patterns were suppressed by SMD 8772 57506 3725 958 3565 4049 PMC3860372__F1 Metabolic Homeostasis: HDACs Take Center Stage 150094 23387 200186 3172 PMC3865046__F1 Proteasome-dependent degradation of replisome components regulates faithful DNA replication 6500 9978 545 84126 5111 8914 4360 54962 1040 PMC3866192__F1 Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure 39 3157 3156 1718 1595 3930 51478 10682 6309 1717 PMC3868343__F2 Molecular basis for synergistic activation through pairs of coactivation receptors on NK cells 6850 2534 867 PMC3868569__F10 TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans 5163 207 208 PMC3871217__F12 Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways 1956 2821 8473 3688 2597 5132 PMC3871639__F5 Inflammation Regulates TMPRSS6 Expression via STAT5 654 164656 148738 6774 4090 4086 PMC3871910__F7 Proposed synergistic mechanisms for induction of mitotic cell death in endometrial cancer cells with mutant p53 7465 4661 995 3925 PMC3874794__F2 An outline of the GPI and GPI-anchored protein biosynthetic pathway 95 93183 2821 128869 PMC3875463__F1 MTOR pathway and epilepsy 5728 10000 5290 6009 1977 PMC3875894__F1 Pathway Protection Loop 5163 7248 253260 PMC3875894__F3 mTOR signaling pathway (#hsa04150) 100302190 3205 5163 2475 253260 7248 7249 1975 6009 1977 673 PMC3875938__F1 The mechanisms of Wnt/Beta-catenin pathway repression by 1,25(OH)2D3 in human colon carcinoma cells 4040 4041 999 7421 6925 595 1499 PMC3876931__F10 Differential regulation of the REGG–proteasome pathway by p53/TGFB signalling and mutant p53 in cancer cells 4088 3065 25942 PMC3877719__F1 Analysis with NIH DAVID, Princeton GO term finder and Ingenuity Pathway Analysis yield similar gene enrichments, biological processes and pathways.The high confidence hit list was also analyzed by IPA for biological pathway enrichment 6241 10155 7374 3692 23569 3691 826 489 9201 5336 84687 5332 8989 10093 762 553 PMC3877845__F1 mTOR signalling pathway 2885 64223 2475 253260 7249 3091 6009 7528 PMC3878201__F4 miR-34a mediates paclitaxel resistance via both direct and indirect mechanisms 6935 9839 23411 596 1021 999 PMC3882126__F1 Autism genes keep turning up chromatin 85358 9378 54413 2562 26047 2475 57680 221037 6601 6599 57492 8243 4204 546 4152 PMC3882682__F8 Canonical pathways 718 975 930 1380 7099 3566 4064 5879 640 6850 695 8915 PMC3889557__F10 Schematic representation of eHsp90A signaling pathway 207 208 4035 PMC3890408__F2 Cooperating mutational events in MYC-driven lymphomagenesis and novel therapeutic opportunities.Notes: Continuous MYC expression is required for BL cell survival, as demonstrated by the apoptotic effect of the MYC inhibitor 10058-F4 on BL cell lines 3399 1021 2932 613 5728 4193 4194 90427 PMC3891875__F1 Wnt signaling 324 1499 6010 51701 860 4040 4041 PMC3892554__F2 TRB3 at the crossroads of ER stress and mTORC function 2475 83939 468 PMC3893930__F2 Ewing’s Sarcoma: Overcoming the Therapeutic Plateau 3479 3480 2885 7249 7248 6009 2475 253260 2313 PMC3894712__F4 Autophagy in Kidney Health and Disease 9474 9140 2475 PMC3895947__F4 Wide variety of glycoconjugates such as heparin sulfate proteoglycan (HSPG), chondrotin sulfate proteoglycan (CSPG), N-glycosylated cystatin C, and galectins-1 are involved in signaling pathways inducing proliferation and self-renewal of NSCs 3976 3977 2885 6774 PMC3896667__F5 Significantly altered pathway in primary tumor 8312 1793 3908 1398 3913 4609 4316 5156 4193 2033 867 545 7157 5925 5591 PMC3898176__F2 Toll pathway 4615 8772 23118 7186 PMC3899195__F6 ZNF365 promotes stalled replication forks recovery to maintain genome stability 991 324 995 PMC3899875__F5 MiR-15a in the AD pathway 351 23385 3416 4023 348 572 836 842 841 8772 637 6622 100506742 7124 2932 840 PMC3900298__F5 New immunological approaches in treating and diagnosing CNS diseases 7442 6469 2737 2735 2736 PMC3901115__F2 Autophagy pathway: Molecular features 9776 2475 55626 9140 PMC3901118__F3 Overview of the Ras/PKA pathway and relevant regulatory connections involved in the yeast pseudohyphal growth and autophagy responses 9776 27010 4582 PMC3902842__F3 Molecular mechanisms involved in leptin receptor signaling in the hypothalamus 3717 6774 8660 PMC3905229__F2 Wnt/GSK- 3B pathway 324 2932 4131 PMC3905307__F1 Canonical (A) and noncanonical (B) Wnt signaling pathway represented by KEGG analysis 11197 27123 6422 6423 57216 7157 5332 1857 59343 23002 6477 6500 324 6907 818 63928 5530 5532 5535 387 5881 5568 8945 23291 8454 5515 57680 4773 51701 595 3725 4316 PMC3907011__F5 Schematic diagram of the Bcl-w-induced signaling pathway by the activation of Sp1 6667 79923 6657 PMC3909204__F1 EGFR and FGFR Pathways Have Distinct Roles in Drosophila Mushroom Body Development and Ethanol-Induced Behavior 1956 6010 3343 PMC3910266__F2 NOD1 signaling and interactions with Rho GTPases and NFATc 10392 759 5879 998 8767 PMC3912738__F3 The interplay between the canonical Wnt/Beta-catenin pathway and IGF signaling 1499 3667 2475 2932 51176 324 PMC3912738__F5 Proposed model for the interaction between Shh and IGF signaling 6469 3667 6608 27148 2932 2475 648 PMC3912804__F1a Hedgehog signaling pathways in vertebrates-without hedgehog ligand 5727 6608 51684 PMC3912804__F2c Hedgehog signaling pathway in cancers -Type III- Paracrine Ligand-dependent cancers 2735 6608 5727 PMC3912804__F2d Hedgehog signaling pathway in cancers -Type IIIb-Reverse Paracrine Ligand-dependent cancers 5727 2735 6608 PMC3913901__F3 cIAP1/2 regulation of TWEAK-induced non-canonical NFKB pathway activation 7186 7187 5971 PMC3914472__F1 Metabolic pathway of the glycine cleavage enzyme system and the synthesis of its lipoate cofactor 23479 27247 200205 388962 150274 51218 2242 275 11019 350 2653 387787 51601 2731 355 PMC3916222__F2 Mathematical Modeling of the Phoenix Rising Pathway 718 730 4513 PMC3917325__F1 Chondroitin sulfate and HS biosynthesis 2135 2137 27087 135152 26229 11285 126792 64131 9917 55790 64132 55454 50515 55501 166012 113189 9469 56548 51363 29940 10090 22856 79586 337876 PMC3919687__F6 Kinetic changes in gene expression of selected components of Th2 responses 2623 6778 3718 8651 4094 7297 6774 PMC3919808__F9 Pathophysiology of Acute Kidney Injury 355 2021 637 8772 56616 27429 PMC3921548__F1 Overview of arachidonic acid metabolism 26136 4512 5226 4049 4050 PMC3922094__F2 Pancreatic cancer pathway diagram 1950 7039 2735 5728 208 3845 7157 PMC3923149__F2 Co-regulation of hepatic wound healing and regenerative responses via TWEAK- and LTBeta-mediated cellular cross-talk 6347 3383 4055 4050 PMC3924769__F6 DAF-12, a nuclear hormone receptor regulating development and lifespan 80270 1593 8309 100 PMC3926678__F5 Repetitive hypoxic preconditioning suppresses adaptive immune responses in resident B cells prior to stroke 3592 1499 958 51588 604 3565 6418 23765 2590 6772 3662 3659 1236 6773 602 6778 7124 581 2033 3661 1387 5966 4793 811 3135 3122 3108 3112 3133 3123 3106 474382 3119 PMC3926887__F6 Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells 1610 627 4351 6722 355 1616 4149 929 23118 51295 51701 PMC3928842__F1 TLRs signaling pathway 7097 10333 7100 7096 7099 114609 4615 54106 51284 7189 203 7098 PMC3929107__F1 Regulation of Hippo pathway and implications for anticancer drug development 8877 4018 6010 9113 26524 PMC3931120__F7 In Utero Exposure to Second-Hand Smoke Aggravates the Response to Ovalbumin in Adult Mice 7153 1356 100034700 6288 6369 6403 10563 1462 6354 PMC3931425__F1 Diagram of known egg activation pathways in Drosophila, Xenopus, and mouse 1325 324 991 PMC3931461__F1 Progress in molecular-based management of differentiated thyroid cancer 5728 673 5163 2475 PMC3935308__F2 High-confidence reaction map of the TSLP signaling pathway 85480 64109 3716 3717 6714 4067 3932 3055 2242 695 7006 100124696 4792 9846 85451 6775 207 4791 4609 1154 7054 PMC3936936__F1 Network of interactions between products of candidate genes from the QTL regions 5777 920 3458 474168 3558 4067 5091 50616 6364 5340 6648 334 351 8676 5270 308 716 1969 7709 5293 2475 PMC3937033__F8 T cell PPI Network mapped to TCR, with main JAK-STAT and MAPK signaling pathways 29851 1956 919 6957 3932 2534 27040 387 4351 5970 5966 6722 PMC3938254__F7 Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis 1030 19 4035 1874 811 PMC3938550__F5 Comparative Genomic and Transcriptomic Analyses of LNCaP and C4-2B Prostate Cancer Cell Lines 2335 7450 5649 6714 5293 387 1793 PMC3940258__F5 Paramyxovirus inhibition of IFN signaling pathways 7297 3716 6772 57762 6773 PMC3941921__F2 Highest scoring upregulated network: Cellular Assembly 4744 4741 4747 9118 5339 5630 7431 6853 4000 57471 4133 4627 PMC3941921__F3 Highest-scoring downregulated network: Energy Production, Metabolism and Cell Structure 5216 817 7534 7531 7529 478 6546 291 476 PMC3942890__F1 ER stress signaling pathway 22926 83939 468 PMC3943663__F1 Dendritic cells in progression and pathology of HIV infection 920 7852 1234 3383 85363 25939 PMC3944264__F6 Proposed model for miR-542-3p-mediated suppression of osteoblast proliferation and differentiation 655 4090 4086 860 PMC3953130__F2 Ack1 signaling pathway in normal and cancerous cells 51741 3099 7113 PMC3957180__F1 Scheme depicting interactions of the ET and NO pathway as described in this chapter 4843 4842 4846 PMC3957735__F2 Short-patch base excision repair pathway 7374 5111 7515 142 PMC3960188__F2 mTOR pathway in colorectal cancer: an update 2475 6446 253260 2887 PMC3960371__F4 Autophagy Paradox and Ceramide 10715 581 664 2475 PMC3961481__F1 Novel pathway links telomeres to NK-cell activity 1200 25913 545 472 9951 PMC3962195__F1 Biological processes and genes implicated in the Parkinson's disease 339855 6622 120892 836 27429 842 PMC3962548__F4 Controlling clot formation 7035 7018 324 5091 PMC3964053__F4 BMP signaling in germ cells across the Metazoa 5225 145258 659 4090 4086 4089 63978 PMC3965173__F1 Signaling pathways that can be inhibited to increase the radiation response of tumors 5728 5163 572 2475 1956 PMC3967868__F1 Drug resistance mediated by AEG-1/MTDH/LYRIC 9474 92140 2308 27044 27161 1806 4609 4318 PMC3968564__F1 1A: Base excision repair (BER) pathway targets DNA damaged during replication or by environmental agents 7515 2067 5887 7508 7507 5890 7516 5892 7517 5889 5893 7518 PMC3974512__F1 Hepatitis C virus entry into hepatocytes 341 348 1956 1969 9076 3949 2885 6464 6010 3265 100506658 8569 29881 PMC3975429__F1 MAPK signalling cascades leading to MK5 activation 5058 5063 5062 PMC3976840__F2 FASN related metabolic and signal transduction pathways 2194 5728 47 31 22937 PMC3977653__F1 At Loose Ends: Resecting a Double-Strand Break 9156 1763 5888 PMC3977821__F6 Robustness and Plasticity of Metabolic Pathway Flux among Uropathogenic Isolates of Pseudomonas aeruginosa 1896 6389 6390 6391 PMC3980962__F1 Origins and implications of pluripotent stem cell variability and heterogeneity 652 4086 3976 6774 2249 6657 79923 5013 10215 7546 55553 6926 5934 PMC3983869__F1 Beta-Catenin is a multifunctional protein that localizes at cell-cell contacts, the nucleus, cytosol and centrosomes 999 324 2932 1499 PMC3985673__F5 Immune activation-related modules differentially correlated in NSCLC 55342 55179 6095 9781 5244 971 3112 1380 29760 3702 26228 25780 266710 940 914 PMC3986510__F4 Diagram demonstrating sites of interference by various small molecule agents or genetic ablation of enzymes engaged in ceramide and sphingolipid synthesis pathway 10715 253782 91012 204219 29956 79603 PMC3986565__F1 Molecular pathways leading to cross-presentation in DCs 64167 51752 6891 6890 PMC3988238__F1 Dendritic cells initiate T cell immunity in the lymph nodes 2625 6778 6775 50943 940 958 941 6774 PMC3989821__F2 Prostate smooth muscle contraction and assumed connections to the regulation of prostate growth 6010 2002 6722 PMC3992201__F2 Genes identified in GWAS of Phase 1+2 AA subjects using a case-control model in the canonical pathway “calcium signaling.” The gene or gene families with a significant association result are shown in orange 130589 790 811 847 PMC3992244__F3 Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer 5728 7249 7248 PMC3994501__F9 Signaling pathways for LTM formation upon associative olfactory conditioning of honeybees 770 1431 847 3382 PMC3994729__F4 Expressional regulation of genes linked to immunity & programmed development in human early placental villi 3717 3718 3716 6774 441549 7297 PMC3994912__F2 Can Transcriptomics Provide Insight into the Chemopreventive Mechanisms of Complex Mixtures of Phytochemicals in Humans? 3458 7099 8772 148022 56616 7187 1432 7186 847 7189 90427 5170 7341 468 1616 581 5077 PMC3995293__F5 Oxidative Stress-Associated Protein Tyrosine Kinases and Phosphatases in Fanconi Anemia 472 545 3458 6772 PMC3995856__F4 Pathway analysis and molecular interactions of focus genes AKT, CTNNB1, GAB2, and SERPINE1 (hightlighted in pink) 10256 5783 4486 8821 57572 10413 9744 5291 1499 9846 26353 5054 5207 80146 146850 PMC3996895__F1 Biogenesis of canonical and mirtron miRNAs in animal cells 29102 54487 5901 PMC3997115__F1 Caspase activation by the extrinsic (Fas-mediated) apoptosis pathway (left) vs 355 114548 8772 PMC3999257__F4 NRG1 signalling and neurite formation mediators 5966 80146 4790 5566 117145 11075 5583 2002 PMC3999750__F4 PAR1 and PAR2 modulate TLR3-dependent expression of IFNB in CFs 4322 7018 7098 3661 PMC4001531__F4 Melanoma NOS1 expression promotes dysfunctional IFN signaling 3717 7297 3716 581 3434 10379 3659 3437 5696 2868 2534 156 5906 2922 673 PMC4001841__F1 PI3K-AKT pathway and associated cellular activities 6714 5266 5163 4193 2932 572 1499 1977 PMC4001935__F7 FoxD3 regulates cranial neural crest EMT via downregulation of Tetraspanin18 independent of its functions during neural crest formation 27022 90139 6663 PMC400410__F4 Functional associations of hypervariable (HV) genes in patients with juvenile rheumatoid arthritis (JRA) 1509 2524 4654 10127 7040 3458 7124 1611 5903 3107 3105 2315 PMC4005613__F1 Molecular Pathways: Co-Expression of Immune Checkpoint Molecules: Signaling Pathways and Implications for Cancer Immunotherapy 962 324 3902 920 11126 151888 1493 3932 7535 2475 PMC4005972__F4 Proteins involved in the BCR signaling pathways 2534 387 55824 1445 5336 4067 638 572 5879 2922 8915 2475 10892 1021 1019 6722 PMC4006928__F1 DNA Damage Response, Redox Status and Hematopoiesis 5728 472 637 6648 648 PMC4007780__F1 CADBIOM model for the canonical TGFB pathway 140805 367 10131 7038 64750 PMC4008226__F8 A mechanism for integrated regulation of motility and adhesion in T cells and its role for transendothelial migration 6387 4035 3383 961 7852 PMC4012261__F6 Graphical representation of the genomic neighborhoods of SRF and ZNF350 545 5728 472 5328 6678 920 5341 3915 3781 10290 898 4026 9770 5396 2934 6876 6609 2316 8437 195828 83481 5829 35 3611 6277 59 8648 55742 5325 59348 51181 334 6667 148398 1674 PMC4012889__F1 Intricate network of TLR signaling and miRNAs 7099 4615 51135 3654 7189 23118 10454 8195 29102 54487 PMC4013446__F2 Functional significance of differentially expressed miRNAs—miRNA-512-5p, 190a and 200b-3p (Ingenuity pathway analysis) 92 55824 8434 9962 4478 9475 10381 673 9693 5598 2889 23592 84295 6196 6874 PMC4017641__F1 O-glycan biosynthesis/human version pathway 2589 2590 2591 8693 2651 11227 51809 9245 PMC4021040__F2 Targeting glioma stem cells: a novel framework for brain tumors 1950 1956 5728 PMC4021575__F3 Ribosome assembly and Insulin signalling pathway 4049 6476 759 355 3630 3643 7249 6009 572 PMC4023363__F1 PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 367 5728 1958 5163 572 7249 2289 2475 6009 2887 7942 8408 9776 PMC4023818__F10 Working model 7248 7249 6194 5187 PMC4024346__F1 The ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras 2885 5894 4214 10013 2353 3726 572 PMC4027041__F1 Hepatic S-adenosylmethionine (SAMe) metabolism 27232 635 4397 4524 191 875 PMC4029965__F7 Predicting Response to Preoperative Chemotherapy Agents by Identifying Drug Action on Modeled MicroRNA Regulation Networks 2099 9212 6789 701 7272 81602 7357 57733 2064 5241 PMC4037130__F1 Targeting protein prenylation for cancer therapy 5900 7074 9610 5163 998 5879 6010 4193 572 7248 7249 6009 PMC4037924__F1 Ancestral Ca2+ Signaling Machinery in Early Animal and Fungal Evolution 4281 759 100507436 4827 3954 PMC4038464__F3 Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease 6513 6514 6515 6517 6518 3098 3099 2645 2821 2203 8789 226 229 230 95 26330 2597 9524 7167 1891 5230 5232 2194 5223 5224 2023 2026 2027 2805 5105 4190 5091 4191 3939 3945 3948 51660 25874 10449 26063 31 130752 5106 5162 8050 80201 2819 PMC4038991__F4 Circadian Redox and Metabolic Oscillations in Mammalian Systems 8863 5187 8864 9575 1407 1408 406 4862 10135 5153 PMC4039369__F1 Yeast pathway map of nucleotide degradation and ribose salvage 10533 5238 7084 6886 7167 PMC4040260__F2 Apoptotic cell clearance: basic biology and therapeutic potential 107966124 3146 387 140885 961 PMC4040986__F2 An Expanded Genomic Representation of the Phylum Cyanobacteria 132 729 140805 1431 PMC4042834__F4 An example of a KEGG pathway containing genes involved in multiple processes 4214 5970 4137 4803 468 673 1950 1956 2002 2885 4893 5894 6722 2005 4342 4609 4763 2768 5922 5921 63928 2353 367 8491 2122 9448 3725 998 1386 836 7157 7124 7186 356 355 1649 1616 4149 10454 4208 929 23118 7189 3315 5495 51295 51701 PMC4043215__F1 Hypoxia-Activated Pathways Leading to Cancer Stem Cell Maintenance 100133941 8788 5460 PMC4046017__F4 Inhibition of IFNg signaling by MAP 7097 8411 5524 PMC4047132__F2 Cellular functions of proteins commonly mutated in uveal melanoma 23451 8314 171023 672 PMC4048454__F5 Metabolic pathway of vancomycin biosynthesis 11113 5817 2733 PMC4048946__F1 Metabolic pathways regulating oxidative stress and endosome traffic controlling the recycling of receptor and adaptor proteins between the cell surface and lysosomes 920 914 3932 27040 5335 2475 4284 942 23607 867 6786 PMC4051228__F1 The folate/Hcy metabolic pathway 5981 4524 7298 4552 875 4548 1719 PMC4052206__F6 Ingenuity pathway analysis (IPA) displaying regulatory relationships among highly expressed (green) and lower (red) placental transcripts in less muscular women as compared with women with high arm muscle area 5698 5696 3123 3659 4261 163351 6672 5970 3458 7940 958 29851 6648 712 713 PMC4052347__F5 PPI network and signaling pathway analysis 836 5468 5601 5595 83933 1432 4793 8841 3725 51564 1387 2353 55869 4772 5931 5599 4216 2944 23246 PMC4052759__F1 Autophagy regulates p62/SQSTM1 levels to control multiple pro-oncogenic signaling pathways 8408 9776 60673 10533 9474 9140 2475 9817 PMC4052811__F2 Deduced pathway of sterol biosynthesis in N 3652 6608 1718 PMC4054417__F3 Distinct regulation of apoptosis pathway genes in neurons and fibroblasts in response to VZV infection 8772 8717 7186 637 9531 2021 4170 4615 596 54205 317 4793 4794 9093 PMC4055569__F8 Augmenting Microarray Data with Literature-Based Knowledge to Enhance Gene Regulatory Network Inference 5111 2194 6774 4613 7161 2475 79923 1616 1950 1112 900 3725 8837 7157 604 638 1398 5728 581 7124 472 1017 4193 PMC4056054__F1 Co-culture with M38 melanoma upregulate interferon signalling pathways 9242 3458 6773 2353 3659 2813 PMC4057522__F8 Possible mechanism implicated in tamoxifen resistance in the TAMR cell line model 595 6658 6659 6662 9580 PMC4058364__F7 HRG-mediated signaling via mTORC2 to mTORC1 3273 5163 7249 6009 2065 2066 2064 PMC4060956__F1 Abnormal Ca2+signaling in SNc DA neurons may cause mitochondrial oxidant stress, proteostasis deficits and eventual cell death 4666 120892 65018 PMC4061247__F3 Nuclear Trafficking in Health and Disease 10128 10482 1977 2733 5902 10763 PMC4064951__F2 Resistance to BRAF inhibitors: intrinsic and extrinsic mechanisms.Notes: Multiple different mechanisms have been described in resistance to BRAF inhibitors 3480 1956 4893 5728 5266 2475 1019 PMC4065011__F5 Ablation of Coactivator Med1 Switches the Cell Fate of Dental Epithelia to That Generating Hair 89780 6469 340706 5549 7450 10218 51129 51378 4239 8534 8785 84034 3485 6662 7503 117581 1958 3416 6280 6279 3858 3848 3868 7051 960 4322 2353 3169 3725 PMC4066587__F2 The stomatal signaling pathway 2077 578 64326 51411 PMC4066639__F5 Stress-signaling pathways in C 5879 998 2936 5163 1255 811 6667 PMC4068285__F4 LM infection in microglia 3716 6609 950 6772 929 7097 6351 572 PMC4074185__F3 Hereditary leiomyomatosis and renal cell carcinoma 3939 5163 9817 8452 PMC4077930__F3 mTORC2 in the center of cancer metabolic reprogramming 3099 2539 5226 5214 6888 22934 5163 3939 2744 PMC4081729__F5 Modification of the Nrf-2 and NFKB signaling pathways by phytochemicals upregulates antioxidant and detoxification enzymes and suppresses inflammation 9817 8452 6648 596 4094 PMC4083090__F7 A model of the role for ATRIP SUMOylation in the ATR pathway 545 84126 11073 PMC4083693__F1 Wnt signaling is required for long-term memory formation 1000 474168 324 1499 7008 PMC4084552__F1 IL-33/ST2 signaling pathway 90865 6761 59307 4615 51135 7189 3717 PMC4086482__F1 Phosphoinositide-3-kinase-Akt-mTOR pathway 5163 5728 2475 7248 7249 6009 1977 PMC4089392__F1 Toward the development of podocyte-specific drugs 7099 11346 7225 2534 7448 PMC4089452__F2 Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease 7248 7249 6714 4609 23411 5163 2932 1499 5728 PMC4095565__F2 NOD1 and NOD2 signaling cascades 10392 64127 637 55054 9140 9474 331 7186 7188 7189 23118 257397 10454 85451 PMC4097318__F1a Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis 6347 7124 80339 PMC4098942__F3 Cancer model pathway 55327 1950 171013 1956 1894 2885 5781 387 4139 8844 27023 3215 PMC4099115__F4 IPA metabolic interaction network of plasma metabolites having a significant correlation with polyp counts in association with aGenotypebyDietinteraction effect 26136 2241 9049 351 PMC4100379__F5 The proposed mechanism underlying the inhibitory effect of MLN4924 in prostate cancer cells 81620 4998 7465 PMC4104073__F2 Splicing regulation of the androgen receptor (AR) and phosphoinositide 3-kinase (PI3K) signaling pathways 2263 5728 7249 7248 367 6009 6426 2289 27044 4609 PMC4104311__F2 Small System—High-Resolution Study of Metabolic Adaptation in the Central Metabolic Pathway to Temperate Climates in Drosophila melanogaster 11181 2539 25796 5226 3073 2805 4190 6395 5091 4191 2806 6392 PMC4104414__F1 Figure shows the endothelial response to a high salt diet 7040 4087 5728 4846 PMC4104445__F1 Life in the bile duct 2059 7099 1164 7272 991 699 9055 701 54894 4089 7157 3845 6092 10164 3569 9112 PMC4104550__F1 ALK signaling pathway with its cross-talk with other pathways involved in the resistance to ALK-inhibitors 238 3717 3718 2885 2932 2353 2475 572 PMC4107957__F1 Toll-like receptors and TLR-mediated signaling pathway 7097 10333 7096 7100 7099 7098 54106 51311 51284 4615 114609 51135 3654 3656 7189 7187 29110 3661 3665 PMC4109688__F2 Toward T Cell Protein–Protein Interaction Activity Relevant to Alopecia Areata 27040 3932 7535 PMC4110660__F2 In silico network and pathway enrichment analysis 10294 6729 3157 51663 11083 3306 29889 2539 5684 23032 3301 4087 2821 10273 5706 5708 4609 5701 2618 3614 2956 9500 10598 64759 4775 1387 891 10105 7324 5717 1869 2099 7316 25929 672 5928 9972 23013 221150 79711 2033 55636 7157 7514 220992 9631 23635 196528 3838 80312 5594 10664 1725 51341 23309 4673 3066 9759 63977 10320 22806 51185 8451 1642 8450 PMC4110715__F5 GeneGo graphic representation illustrates Transcription Androgen Receptor (AR) nuclear signaling 3479 1950 1956 2885 4088 6774 3265 10499 23426 8648 5594 4313 22937 PMC4111749__F2 Regulation and roles of Cdc7 kinase under replication stress 353497 8317 5889 56852 2177 PMC4111995__F2 Molecular insights into NF2/Merlin tumor suppressor function 60485 4485 9113 26524 64398 154796 PMC4112160__F2 Surviving Change: The Metabolic Journey of Hematopoietic Stem Cells 5728 7249 7248 2475 PMC4112529__F1 Pathway for CoQ biosynthesis in eukaryotes 27235 51805 51004 7054 10229 84274 PMC4114929__F3 Importance of RhoGTPases in formation, characteristics, and functions of invadosomes 998 387 389 7408 PMC4115241__F5 Schematic drawing showed activated HFSCs contributed to SN development 1499 947 6662 PMC4116528__F9 Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3B signaling pathway in non-small-cell lung cancer 4086 2932 79923 PMC4120684__F2 Comparison between recombinant Shh- and EVsShh+-activated pathways modulating angiogenesis and apoptosis in endothelial cells 6469 6608 387 3082 4312 PMC4124053__F2 Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists 7124 581 56616 PMC4124796__F1 Signaling pathways of leptin and insulin in the CNS 5163 3953 3643 8660 2308 5443 181 PMC4127075__F1 Regulation of EMT by KLF4 in Gastrointestinal Cancer 1045 9314 10410 648 6700 595 2305 3851 891 PMC4128657__F4 An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients 51284 6041 3661 PMC4128997__F3 PPAR signaling pathway 5360 2170 4312 7350 3611 7316 PMC4130902__F2 G-protein—coupled receptors, hedgehog signaling and primary cilia 2736 51684 2121 84455 132884 23288 6469 6608 2737 PMC4132214__F2 Pathways modified in OCC upon MSC contact related to adherence, migration, and invasion 3038 4811 10628 467 7422 27122 10631 6935 1326 8473 627 1009 23213 5069 4314 10451 PMC4132784__F7 Mechanism by which the PTEN-PI3K-AKT-MDM2 signaling axis exerts control over HIF1A degradation in cytoplasm under hypoxic conditions via the MDM2 E3 ligase and 26 S proteasome 5163 5728 4193 5266 7428 9978 PMC4134342__F2 Sortilin, a novel APOE receptor implicated in Alzheimer disease 348 3949 4035 PMC4135311__F2 Sirt1/AMPK/PGC1/PPAR signaling network 2308 5465 4280 PMC4139724__F3 Functional features of gingivitis-associated microbiota 4397 2313 55137 PMC4141691__F5 Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease 5728 253260 1975 6199 2475 2690 PMC4142215__F1 Genome wide proteomics of ERBB2 and EGFR and other oncogenic pathways in inflammatory breast cancer 1950 367 685 3725 126669 2066 2475 572 867 6965 PMC4143103__F2 Canonical and noncanonical TGFB signaling 7048 7046 4087 4088 387 6497 4089 PMC4144112__F1 Genistein modulates a critical TGFB signaling pathway in human prostate cancer 2022 4086 4088 9261 4280 PMC4144918__F1 Do Mantle Cell Lymphomas have an “Achilles Heel”? 613 958 4067 7187 6850 7186 581 596 4170 695 2475 5971 1021 1019 472 4193 4194 PMC4145234__F1 Regulatory networks of miRNAs and PI3K/AKT pathway in controlling EMT and cancer stemness in human tumors including endometrial cancer 2146 5728 2475 406971 7291 6935 PMC4145387__F2 E-cadherin regulated signaling pathways involved in gastric cancer 960 1499 51176 4316 999 387 5879 6010 998 1956 7124 PMC4146087__F1 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder 627 2885 126669 PMC4146087__F5 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder 627 6750 100187761 PMC4146646__F11 Schematic summary indicating the mechanism by which Cdt, specifically CdtB, affects the PI-3K signaling pathway and the production of pro-inflammatory cytokines 4615 7189 2932 PMC4147769__F2 Possible mechanisms of autophagy in mammalian cells 2475 9776 5266 22863 9474 55054 9140 64422 83734 10533 PMC4148370__F2 Differentially expressed genes (DEGs) in the B-cell receptor signaling pathway 933 6850 613 4067 29760 695 1610 975 930 PMC4148370__F3 Differentially expressed genes (DEGs) in the T-cell receptor signaling pathway 920 3932 867 2534 7535 27040 3702 1019 8915 940 2885 PMC4149467__F6 GATA regulation of Notch signaling in the intestine 28514 3938 2168 474 4583 PMC4150779__F7 Functional relevance of rapid transcriptional silencing in activated DCs 4615 6850 51135 3654 114548 64170 10892 7189 8915 4048 4050 4049 4512 PMC4154379__F9 Tumor Necrosis FactorA Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor-Beta-activated Kinase 1 (TAK1)-dependent Signaling Pathway 7124 8717 7186 8772 PMC4155175__F3 mGluR1-TRPC3 signaling at parallel fiber-Purkinje cell synapses 7222 6010 2747 PMC4156316__F2 Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis 2932 387 2305 999 1499 PMC4159950__F2 MicroRNAs As Biomarkers For Clinical Features Of Lung Cancer 407006 5728 4609 2146 PMC4162460__F8 Schematic for reprogramming of EBV-induced glucose metabolism 2932 3099 4609 PMC4163633__F1 Innate recognition of HCV RNA 7186 7189 8717 7188 3661 7187 29110 9636 57162 10454 23118 57506 7098 PMC4167018__F7 Modulatory effects of low-dose H2O2 on the functions of pDCs 5132 941 9308 942 54106 51284 4615 3665 7124 958 PMC4167215__F1 The mitochondrial unfolded protein response in mammalian physiology 83939 9361 59286 PMC4167267__F7 Observed tumor patterns 2078 5728 4763 728378 1027 23451 2120 23345 324 9743 2932 29072 9817 7015 4824 100132406 1105 2308 5903 1499 6794 288 2201 675 6597 5925 673 5604 3265 7157 2475 PMC4169059__F2 AC in vascular endothelium 6714 857 9817 4513 7412 3383 1728 PMC4172882__F1 (Rspo)s in canonical Wnt signaling pathway and the general architecture of (Rspo)s 1499 7008 1380 PMC4176492__F2 Role of cell cycle regulators in the cellular dormancy (“intrinsic dormancy”) mechanism 6502 324 999 1874 PMC4176946__F2 Ketone bodies as signaling metabolites 7248 5465 26291 3170 23411 2309 23410 23409 23408 PMC4177363__F5 Transcriptional response to dietary restriction in Drosophila melanogaster 11201 1311 4809 51602 55651 55505 1736 84916 10436 51096 55813 5822 55272 92856 6023 28987 5901 51068 55341 4733 PMC4177745__F9 GLD-4-Mediated Translational Activation Regulates the Size of the Proliferative Germ Cell Pool in the Adult C. elegans Germ Line 4846 79018 6770 PMC4178135__F3 Standardized pathway diagram calculated with a structural equation model of antepartal hormones in pluriparous dairy cows 2006 3426 192 PMC4178922__F2 Fgf7 and Fgf10 signaling via Fgfr2b controls proliferation versus chemotaxis, respectively 2252 2255 23677 PMC4179759__F1 Melanoma signaling pathway 4893 673 5728 PMC4180639__F7 Putative model of Ahnak-dependent activation of TGFB signaling 4092 4087 4088 79026 PMC4181300__F2 Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes 5321 6401 4317 7097 3570 7422 1588 5444 3593 4312 3566 1719 7133 4846 5742 7077 4318 3587 3554 4057 3557 7850 4313 7132 4314 7424 3606 3559 1493 3569 154 3586 4319 51284 2155 5327 7060 183 3556 4793 613 5054 2246 2153 6347 64127 3304 3303 3479 2908 3339 7078 3458 7253 6337 3600 3588 6777 6776 7066 10857 4522 PMC4181300__F3 Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes 929 4312 7133 4319 1462 3552 7157 7124 355 3990 3458 4843 4846 3479 1435 5327 2152 3480 183 6916 5972 7450 2249 7077 PMC4182081__F3 Regulation of TCF7 and HSP90AA1 by hsa-miR-185-5p in a prostate cancer pathway 367 5728 4193 596 PMC4183579__F3 Role of MicroRNA Modulation in the InterferonA/Ribavirin Suppression of HIV-1 In Vivo 3866 5371 494334 11200 6273 10346 7157 4782 4175 64065 9898 5286 2633 5981 4343 6598 1643 9636 51191 6773 91543 5610 7374 PMC4184787__F2 Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways 5360 1508 8435 57552 4258 3606 3661 7038 6420 PMC4189590__F7 Proposed model of the mechanisms involved in PAF-mediated EGFR transactivation in SKOV-3 ovarian cancer cells 1839 1956 6714 PMC4189793__F1 Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione 6714 27035 50507 PMC4190549__F1 The PI3K/Akt/mTOR pathway 5728 5163 2475 572 355 595 PMC4197574__F3 Studying ultradian oscillations using optogenetic tools 429 1408 2475 PMC4199593__F6 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana 5879 51135 54472 57506 3654 3656 7187 7189 8772 51295 10454 6772 29110 3665 2475 3661 5292 51284 4615 7098 51311 114609 10333 PMC4199881__F1 Role of GKN1 in gastric cancer 56287 1499 841 836 999 4513 1786 2146 PMC4200801__F3 Current strategies to generate tolDCs 3586 2475 942 941 958 3569 2625 PMC4201220__F2 Wnt/Beta-catenin signaling pathways and a strategy for the phenotype-based drug identification using C 2932 1499 324 90196 10940 PMC4202123__F1 Structural basis for cancer treatment decisions 2885 1956 5728 2475 2002 6722 PMC4208300__F3 Simplified outline of the MyD88-signaling pathway by which TLR agonists induce the production of inflammatory mediators 4615 51135 3656 7189 23118 257397 64784 7124 PMC4209854__F1 EGFR signalling in chronic lung disease 1839 1950 7039 9592 PMC4214635__F2 De Novo Mutations in Moderate or Severe Intellectual Disability 6792 4204 23327 63035 112939 7528 1654 27183 7846 4036 6925 10492 1499 5528 3192 1958 55870 10274 79868 5521 7204 2903 2902 3800 2904 1759 8243 1778 4035 2316 6262 818 10369 8260 6709 5500 6326 9945 2890 55339 8831 26040 3785 773 288 4628 85358 2036 28964 547 3786 6418 5160 PMC4215754__F3 KEGG B cell signaling pathway tuned in CD19 B cells and CD4 T cells 933 971 6850 973 4067 5879 29760 695 5336 2885 6654 3265 5894 5594 2353 5579 84433 8915 1147 4790 930 10000 1380 10451 2932 PMC4215754__F4 KEGG B cell signaling pathway after tissue specific and PPI-based tuning in CD19 B cells 933 971 6850 5880 7410 29760 4773 2885 6655 3845 6654 11316 5894 3265 84433 8915 1147 4792 4793 3551 5290 4790 207 PMC4218909__F1 Cartoons of protein C activation and APC signaling in the membrane lipid-rafts of endothelial cells 5879 324 5091 PMC4218909__F2 Cartoons of PAR1 activation by thrombin in the membrane lipid-rafts of endothelial cells when EPCR is free or occupied by its natural ligand 387 5879 5091 857 PMC4219592__F1 Interactions between alcohol-induced mechanisms leading to hepatic carcinogenesis 1571 7099 79923 717 PMC4219936__F2 Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice 7099 3553 9965 9294 8877 5163 56848 1581 1810 PMC4222471__F2 RAS signaling pathway and genes mutated in juvenile myelomonocytic leukemia (in black) 6654 2885 4763 3717 867 5894 2475 PMC4223355__F9 Model of PLB1 transcriptional activation upon loss of Ypk1 or upon disruption to sphingolipid biosynthesis through treatment with myriocin 151056 5091 5004 5005 1255 PMC4227423__F2 Differentially expressed genes in the proteasome pathway 6117 6185 3621 1431 51371 PMC4227541__F2 CD40 stimulation stimulates a highly coordinated immune response by epithelial cells (ECs) 64332 4794 4792 PMC4230721__F3 Compounds used as anti-fibrotic therapies in other organs and their mode of action 2475 4092 3082 PMC4231819__F1 Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential 929 4615 7189 3553 3661 PMC4233297__F2 Summary of myocardial cellular effects and the injury response induced by anthracyclines 10725 2475 2626 675 581 836 355 7099 PMC4237952__F4 Complement-induced inflammation pathway: an important mediator of neuroinflammatory processes from M4 onwards 714 721 718 3689 3684 3687 7097 3690 PMC4243952__F2 Impact of cellobiose on central carbon metabolism, amino acid biosynthesis and thiamine biosynthesis of Saccharomyces cerevisiae 1537 54820 1329 4190 48 50 3417 3418 2819 2820 81620 384 252842 252843 2734 2203 383 6886 7167 5230 2026 2023 5105 5131 3651 100996949 4191 84890 PMC4247524__F2 Long-patch BER pathway 5111 2237 3978 PMC4247580__F10 Arabidopsis Lipins, PDAT1 Acyltransferase, and SDP1 Triacylglycerol Lipase Synergistically Direct Fatty Acids toward Beta-Oxidation, Thereby Maintaining Membrane Lipid Homeostasis 355 4023 5091 PMC4250228__F1 Methylation Matters In KRAS Oncogenesis 1839 1956 3570 3845 10419 PMC4251736__F4 Disorders of the PI3K-AKT-PTEN pathway 5290 5296 207 208 10000 5295 5728 PMC4252877__F4 Embryonic development, organ development, organ morphology, cellular growth and proliferation, cancer, and tumor morphology 51316 4345 27352 4915 5420 4222 129080 27347 8540 4731 3875 3169 374 3481 595 PMC4253858__F1 EGFR signaling pathways and receptor cross-talk 3082 2621 3480 558 1956 2475 PMC4254517__F2 Anti- and pro-apoptotic roles of RIPK1(A) Upon TNFR-1 ligation 8717 8737 8772 7186 841 23118 11035 197259 PMC4255921__F1 Canonical and non-canonical TGFB signaling 4089 29102 4087 PMC4258442__F3 Nitrosothiol signaling and protein nitrosation in cell death 581 8772 355 637 331 85451 PMC4259450__F2 Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences 7248 2475 7249 4193 5728 4609 1021 1019 1017 983 1956 PMC4260148__F3 Details of genes in the ‘acute phase response’ biological pathway identified in Ingenuity Pathway Analysis, which are differentially expressed in the frontal section of SHRSP vs. WKY rats at 5 weeks of age 2475 1401 3240 2243 2147 PMC4260876__F7 Drought Tolerance Conferred to Sugarcane by Association with Gluconacetobacter diazotrophicus: A Transcriptomic View of Hormone Pathways 1879 64641 2077 4602 PMC4263025__F1 RAF fusion genes in prostate and gastric cancer and melanoma 673 57085 54845 5894 PMC4263682__F1 An example of a cluster illustrating Ras activation 1950 1956 8826 2885 8161 6285 998 5879 1499 999 324 PMC4264188__F2 BMP signaling pathway 4090 4086 3397 PMC4264417__F3 Notch–EGFR crosstalk in TNBC 1950 1956 4851 PMC4267955__F10 Loss of signaling via GA13 in germinal center B cell-derived lymphoma 286530 9294 10672 9138 387 PMC4270061__F1 Cofilin pathway in breast cancer invasion and metastasis 1956 6714 6010 998 PMC4271569__F8 The most sensitive regulations 1270 2670 4340 1103 4744 4803 PMC4278244__F7 Model representing that Wnt/planar cell polarity signaling contributes to the association between pericytes and developing blood vessels via the Wnt5a-Fzd7-cdc42 axis 7474 998 5091 5053 PMC4278340__F1 Menin-mediated regulation of miRNA biogenesis uncovers the IRS2 pathway as a target for regulating pancreatic beta cells 29102 54487 8660 PMC4279731__F7 RBP-J acts as a master regulator that maintains the identity of the JG cell 4776 6722 1396 93649 6717 9314 1264 6525 83953 2627 PMC4280516__F2 Cellular entry of HCV particles 3265 1956 3949 975 9076 100506658 PMC4281293__F2 To reveal potential pathways involved in pancreatic cancer survival, the Ingenuity Pathway Analysis (IPA) was used for upstream regulator analysis 865 874 50865 3507 7422 292 4239 6418 4191 5093 5515 6649 6277 8039 PMC4281466__F1 TGF-beta signaling pathways 6010 4092 11171 4089 PMC4281710__F2 NOD2-interaction partners influence a wide range of NOD2 functions 114548 57506 91662 4939 84674 64127 64170 5987 9021 14 790 22900 637 50506 55914 143162 58484 5879 51296 9618 54434 55054 22861 PMC4286677__F8 Scheme of interactions hypothesized to connect the receptor protein Draper to the execution of the engulfment process 6714 998 6010 PMC4287622__F3 Protein Interactome of Muscle Invasive Bladder Cancer 1288 3371 3918 3909 7057 3914 3915 3655 3691 2335 4638 1017 581 596 2246 7422 5728 7534 1026 2247 2549 3725 627 572 355 25 2064 5594 1019 1027 5154 1499 4193 1956 3265 7043 5578 836 1500 1843 2066 2065 3791 369 2261 5582 5743 7048 7046 3710 2773 5590 PMC4292866__F11 Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase 4512 860 1300 PMC4293272__F2 Cell Signaling Pathways Involved in Hematopoietic Stem Cell Specification 51384 4851 4086 4090 1499 7422 652 PMC4294344__F1 Bioinformatics analysis of the serine and glycine pathway in cancer cells 26227 5723 5315 27165 6470 2731 4524 PMC4294653__F12 mTOR signaling pathway regulated by PLB in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis 3643 3667 5163 7248 7249 5091 253260 1975 1977 6010 1999 8408 9776 3091 6194 5901 PMC4295939__F8 Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3 11284 5091 472 581 PMC4299585__F10 Mechanisms underlining the sphingosine-1-phosphate (S1P)/sphingosine kinase 1 (SphK1)/S1P receptor (S1PR) 2 signaling axis in pulmonary arterial hypertension (PAH) 9294 124976 8877 6774 5817 5053 PMC4299612__F2 Regulation of Toll-like receptor (TLR) signaling during bacterial lung infections 7099 7096 7097 960 7187 1540 23118 257397 29110 3661 3665 2919 2920 114609 4615 PMC4300719__F6 Pathway analysis in groups A (A) and B (B) 5915 2272 572 842 1869 9846 2064 1610 11186 PMC4300866__F1 Biological functions of the complement system 718 1380 613 1378 721 735 PMC4302085__F2 Proposed mechanisms accounting for resistance to inhibitors of the PI3K pathway 1956 3480 3845 2475 3667 PMC4306671__F3 Pathway enrichment results: (A) hsa05200 (pathway in cancer); (B) hsa05218 (melanoma) 367 3815 5212 673 1019 572 5728 4193 4286 PMC4307161__F16 The Therapeutic Potential of Cystathionine Beta-Synthetase/Hydrogen Sulfide Inhibition in Cancer 875 2805 2806 PMC4307801__F1 HER2-Positive Breast Cancer: Current Management of Early, Advanced, and Recurrent Disease 6714 2885 5728 2475 572 595 PMC4309185__F2 Imd pathway in the fruit fly and the TNF pathway in the mouse 7124 8717 7186 23118 10454 PMC4309185__F3 The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway in the fruit fly and the mouse 3716 6774 4170 4513 PMC4310010__F1 Alterations in selected pathways in head and neck squamous cell cancers 1956 1029 5290 3265 595 5925 5728 55294 8452 9817 4780 8626 PMC4310752__F1 Therapeutic targeting of cancers with loss of PTEN function 5163 5728 5888 PMC4314372__F1 Biology of Castrate Resistant Prostate Cancer 1586 5728 367 4087 4088 6714 4089 2475 4609 1499 6662 407040 2146 2078 6659 PMC4314775__F7 Proposed mechanism of differential regulations of NFKB – miR-29b – p53 pathway by S100A7 in different types of breast cancer cells 6278 998 7528 PMC4322839__F1 Negative feedback loops at the core of transcriptional oscillators 406 9575 4193 3280 PMC4324736__F3 Individual involvement of the products of the eight studied genes (shown in red colour) in the (a) RAS/RAF/MEK/MAPK, (b) PI3K/AKT, and (c) GNAQ/11 signalling transduction pathways 3265 3845 2776 2767 5728 673 5163 4286 2475 PMC4325158__F3 Transcriptomic changes in central metabolic pathways induced by pho13Δ during growth on different carbon sources 7167 6886 2023 128 PMC4326213__F3 Immune-initiated, complement-mediated erythrocyte destruction in cold agglutinin disease (CAD) and cold agglutinin syndrome (CAS) 717 718 727 PMC4326377__F10 Activation of BV2 microglia could trigger a strong inflammatory reaction in PC12 cell apoptosis by toll-like receptor signaling pathway 7099 4615 581 PMC4326712__F2 Simplified synopsis on the PI3K-AKT and RAS-MAPK signaling pathways and their interactions 2885 9846 6009 581 2475 PMC4327877__F8 TGF-Alpha-IL-1A/Beta-IL-1ra autocrine cascade contributes to TNF-induced hepatocyte proliferation and Adv-infection sensitized apoptosis through the regulation of multiple shared signaling pathways 7039 7124 1956 PMC4330251__F3 Wnt signaling pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG) (SFRP genes are in red box) 51701 51024 4089 324 5465 25805 50964 6500 PMC4331529__F8 miR-30 Family microRNAs Regulate Myogenic Differentiation and Provide Negative Feedback on the microRNA Pathway 27327 6603 6591 PMC4334449__F1 Pathogenesis of HCC and targets for chemopreventive agents 1956 5728 4513 4193 2475 4609 1017 PMC4334626__F1 Proposed schematic model showing how the crosstalk between healthy or oxidized/senescent red blood cells (RBCs) and immune cells may exert anti- and proatherogenic effects, respectively 3603 23379 7054 PMC4335352__F5 Example of non-mitotic functions of Plk1: effects on the mTOR pathway 5163 8408 7248 7249 6009 6194 1975 1977 673 PMC4337782__F1 Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy 1950 3976 6469 79923 PMC4339376__F10 Effects of Magnolol and Honokiol on Adhesion, Yeast-Hyphal Transition, and Formation of Biofilm by Candida albicans 27010 1889 253 PMC4340386__F1 Simplified diagram of the sphingolipid biosynthesis pathway in S 95 5004 6493 6492 PMC4340752__F1 UPR, autophagy and mitochondria crosstalk underlies the ER stress response 22926 468 55054 9140 8678 64422 83734 9474 10533 PMC4341198__F8 Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems 847 581 3014 PMC4342183__F2 Wnt signaling pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-181a-5p is a regulator of Wnt 51701 9350 1499 4089 4088 324 25805 50964 6477 6500 9978 9475 23002 387 PMC4342183__F3 Cell cycle pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate a number of important proteins that control the cell cycle 9126 10274 10735 4087 4088 1874 2932 4089 4357 4193 6502 699 9184 991 5111 993 1022 1021 1019 5347 983 1017 324 4661 999 8317 10926 4999 23595 PMC4342183__F4 p53 pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate the p53 signaling pathway 729 472 545 355 841 637 1869 4609 581 836 842 94005 54623 64065 4193 7249 5728 6477 64326 PMC4342183__F6 MAPK signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate MAPK signaling pathways 3925 4803 627 1950 1956 2002 6722 2316 3727 5062 5058 7124 7186 355 1616 4149 10454 23118 4208 929 51701 PMC4342183__F7 Notch signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the function of the Notch signaling pathway 8650 3280 388585 23385 PMC4342183__F8 VEGF signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the VEGF signaling pathway 4513 998 6714 842 572 PMC4344511__F4 Estimation of multi-factor mediated dysregulations affected by the module 3815 10677 7529 8178 58533 8038 717 1950 5728 7018 10664 9118 1956 196 302 PMC4344548__F1 Sites of canonical Wnt signaling deregulation in PD 7473 120892 2932 324 4040 4041 PMC4344885__F6 Endocardial Fibroelastosis is Caused by Aberrant Endothelial to Mesenchymal Transition 1950 182 655 4087 4088 4090 4086 999 PMC4346319__F2 HIF Transcription Factors, Inflammation, and Immunity 3569 10371 5163 3458 4843 PMC4346630__F10 RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL 331 7124 7099 8737 11035 4615 7186 79002 8717 3553 8772 197259 114548 834 PMC4348060__F5 Differential network of breast cancer Cell Cycle pathway between early recurrent and non-recurrent patients 8556 7534 8317 4175 2810 4174 472 8555 701 1869 994 5925 4088 1387 7157 7042 1027 8243 10912 PMC4349157__F1 Sphingolipid metabolic network 2730 2729 2876 2950 26873 2629 6609 4018 PMC4349708__F3 Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms 387 7408 3685 2316 2317 3909 7414 55742 824 3611 998 5728 858 5747 2534 329 572 PMC4350260__F1 NFKB and STAT3 in Glioblastoma: Therapeutic Targets Coming of Age 9021 3716 3717 8717 2146 5789 2475 5300 7422 51147 9208 10401 6774 PMC4351453__F8 A proposed model of our study is shown 7351 6781 2475 PMC4355251__F2 PRR and signaling pathways that lead to differentiation of antifungal T-helper cells 7099 7096 7097 7098 54106 51284 4118 6850 4615 8915 114548 5966 7124 3603 7054 PMC4355473__F2 Change in TNFR1 signaling pathway in 3 h, 12 h, and 24 h groups after cerebral ischemia-reperfusion injury 8717 2645 847 8772 637 27429 331 581 PMC4356243__F5 Advances in therapeutic development for spinal muscular atrophy 627 1950 1956 2885 4280 2002 6607 6722 PMC4359552__F1 Conceptual model of general lifestyle effects, salient CHD pathogenetic pathways and CHD hallmarks 627 10763 7124 114548 4282 7018 7412 1636 4353 3479 PMC4360697__F2 Underlying link between Alzheimer’s disease and type 2 diabetes mellitus.Notes: Insulin resistance reduces the degradation of AB by IDE, and makes the combination of insulin and insulin receptor impaired 3416 23621 351 2932 PMC4364059__F2 TLR and NLR pathways 51135 10392 3656 3654 7189 64127 55054 4615 PMC4366058__F4 Mirin is an antiviral polyamide (AVP) sensitizer 4361 10111 472 PMC4370098__F7 Signalling mechanisms regulating phenotypic changes in breast cancer cells 6714 1445 2475 5728 717 47 7249 7248 PMC4373383__F1 Network of HMGA regulatory mechanisms in human carcinomas 8091 3159 5520 23492 7049 PMC4374983__F1 Serum response factor pathway 387 1729 58509 6722 PMC4374983__F2 Serum response factor pathway in myelopoiesis and myelodysplasia with 5q abnormality 7099 387 929 1958 1495 6722 406935 406937 PMC4380664__F3 Pharmacological targets and signaling cascades proposed to be important in mediating synaptic plasticity underlying extinction 2638 161253 6714 6010 627 PMC4381506__F2 Transcript abundance of genes related to central metabolic pathways under different conditions in K 6667 7083 9049 7167 914 PMC4381889__F4 KRAS-reprogrammed glutamine metabolism in pancreatic cancer.Notes: In KRAS-mutant pancreatic cancer, mitochondrial glutamine flux is reprogrammed to predominantly flux through GOT2, instead of the canonical GLUD1 pathway 4199 4190 3845 2746 2805 2806 4200 PMC4381956__F1 Complement in Monoclonal Antibody Therapy of Cancer 718 720 721 717 1378 727 730 729 735 966 7448 55364 3078 PMC4383338__F9 Scavenger Receptor SREC-I Mediated Entry of TLR4 into Lipid Microdomains and Triggered Inflammatory Cytokine Release in RAW 264.7 Cells upon LPS Activation 7099 929 4615 8195 3661 PMC4385749__F5 Diagram of the neural circuitry underlying delay eyeblink conditioning 5091 2638 1431 PMC4389564__F1 CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6 2919 960 4040 7852 1499 PMC4389579__F1 Conceptual model of general lifestyle factors, salient CHD pathogenetic pathways and CHD hallmarks 7054 100187761 10763 114548 4282 7018 7412 1636 4512 3479 4353 PMC4391565__F10 H3K56 acetylation prevents genomic instability by affecting Ctf4 function 338340 4173 4176 4172 4171 4174 4175 5426 PMC4394389__F8 Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom 4118 1445 387 PMC4394599__F3 Molecular pathway of glutaminolysis in NSPCs 23409 2744 2746 4609 92745 PMC4396872__F3 NOD signaling pathways 64127 57506 7187 3661 331 3665 23118 257397 PMC4397736__F1 Metabolic loops increase pathway multiplicity 5232 55276 2752 3077 2026 26035 PMC4404113__F5 Unigenes involved in the three metabolic pathways 8833 9615 64853 PMC4406277__F4 Pathway visualization 2033 7040 5591 545 9184 472 219972 4088 10744 4089 6502 5925 100188859 896 9134 894 902 999 8556 8317 PMC4410894__F3 Signaling pathways involved in pluripotency 4838 3479 3976 3977 324 2932 1499 79923 6657 PMC4411872__F7 Genes involved in chronic kidney failure (Disease Pathway) 4852 183 3569 9370 2056 3484 5972 4846 1636 5167 6559 729230 2784 4524 7421 PMC4412056__F1 LC-PUFA biosynthesis pathway {adapted from Refs 9415 3992 60481 54898 PMC4412127__F1 Signaling pathway regulation of ΔNp63 51684 2932 3661 3665 2737 2263 1499 6774 1956 PMC4412965__F3 Proteins involved in chromosomal fragility 348654 7486 5888 2067 641 80198 672 2177 472 545 3364 353497 246243 PMC4414696__F3 Simplified TAM signaling pathways in supporting cell proliferation and survival (A) and inhibiting inflammation (B) 2621 8205 2885 9021 8651 PMC4415653__F6 Genetic regulatory network based on published interactions 2002 4205 6667 5970 468 6256 PMC4418510__F1 Canonical TNFR to Nf-kB pathway 8737 7186 8717 7189 1540 PMC4419223__F3 Green tea modulates the various cell signalling pathways in cancer 7124 5728 4015 581 PMC4419739__F4 Cellular and signaling pathway view of gene expression changes during alcohol withdrawal 183 4199 3725 PMC4422156__F2 Poly-IC postconditioning activates the TLR3/IRF3 signaling pathway and increases the IFNB levels and subsequently downregulates TLR/NFKB signaling to decrease the levels of pro-inflammatory cytokines 7098 7099 4615 3661 PMC4422175__F5 Farnesoid X receptor (FXR) regulates enterohepatic circulation of bile acids 5091 64241 64240 1581 2264 9965 29881 PMC4426221__F2 Schematic summary graph shows the postsynaptic effects of mGluR2/3 agonists on the regulation of both AMPA and NMDA receptors 6616 100170220 1445 6714 2932 4553 PMC4426861__F1 Pathogenesis of Aortopathy in Marfan Syndrome and Related Diseases 7046 7189 7018 5328 5327 PMC4427618__F2 Coordination of developmental signalling pathways by USP9X 1950 57154 83737 8239 2475 253260 4089 57534 PMC4427718__F3 Biological network capturing the immune response and the metabolism of glycosaminoglycan and sphingolipid revealed from Ingenuity Pathway Analysis® (IPA®) 939 389816 57584 10538 3073 2517 9516 2588 5373 2799 351 79158 49 3565 PMC4429755__F3 Regulation of miRNA biogenesis as an integrated component of growth factor signaling 29102 54487 3178 PMC4430528__F5 Sharing and Specificity of Co-expression Networks across 35 Human Tissues 894 3738 3560 864 4063 3695 9644 2696 197358 81606 7535 2625 79710 5155 91010 928 919 201633 3932 54910 5858 PMC4431663__F1 Physiological regulation and pharmacological inhibition of the STAT3 signalling pathway 9021 6774 6850 7018 10401 PMC4434706__F1 Two S-phase checkpoint responses in S 5884 1763 4360 PMC4434964__F9 Models of EGF network and CNP/NPR2 signaling in the regulation of LH-induced ovulation 4280 4880 1950 1267 1956 4882 PMC4435535__F1 Notch signaling as a novel regulator of metabolism 6774 182 2194 5105 PMC4437511__F4 Proteins from known pathways localized to the Trichomonas vaginalis hydrogensome 2395 23479 2242 PMC4441389__F5 Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation 5728 2932 999 PMC4444223__F1 Model diagram of tumor necrosis factor-alpha (TNFA) signaling 100187761 7124 8772 637 2002 PMC4445995__F2 Stem cell response to matrix stiffness by integin, cytoskeleton and signal transduction crosstalk 2624 387 2885 10413 6420 5916 6722 4133 2626 860 PMC4446054__F3 Top enriched network associated with BCa progression 6228 5925 10014 55450 595 5728 7323 1827 3488 329 4192 1540 3375 351 2152 7422 301 3673 PMC4447643__F9 Schematic diagram showing the modulation of insulin-mediated glucose uptake in muscle cells by CRFR2 signaling pathway 3667 5163 2475 PMC4449624__F1 Metabolic Alterations Induce Oxidative Stress in Diabetic and Failing Hearts: Different Pathways, Same Outcome 7038 7351 7352 PMC4452102__F1 TLRs in human gastrointestinal pathology: health condition and inflammation 3458 7097 3661 PMC4454471__F3 Model for generation of repeat expansions during MMR and BER 4292 4437 4436 5111 5423 2237 7486 9156 PMC4458296__F1 Purine metabolic pathway 5471 435 270 4860 100 191 7498 PMC4459616__F1 Wnt signaling pathways and the biology of sclerostin.Notes: (A) Canonical Wnt signaling: in the absence of sclerostin, Wnt binds to LRP 5/6 and its co-receptor, frizzled 4040 4041 2932 1499 PMC4459616__F3 Effect of sclerostin inhibition on Wnt signaling.Notes: Sclerostin is secreted by the osteocyte 4040 4041 2932 1499 7008 PMC4463932__F2 Glycosylation pathway defects with known immunologic consequences 84522 5373 7841 10559 2542 92579 56052 79087 55343 5238 920 1234 PMC4465126__F7 Proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and nitric oxide (NO•) generation in PAH 50507 6420 1585 6770 PMC4467383__F2 Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery 23476 8019 2623 6046 PMC4467434__F6 Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer 7048 659 7046 657 658 4087 4088 4086 4090 4093 6498 4089 5091 PMC4467640__F1 Cellular regulation mediated by extracellular matrix (ECM).Notes: The action of ECM components on the major signaling pathways of tyrosine kinase receptors, their links, and the outcome on tumor cell and chemotherapeutic response 3611 5163 9261 5728 572 7248 6009 4609 4193 2475 595 3091 1977 PMC4468843__F1 NFKB pathway 4615 4513 3553 PMC4470683__F7 Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action 6794 4609 6667 1026 PMC4471389__F1 Therapeutic potential of targeting IL-17-mediated pathway 7054 7297 920 3603 149233 PMC4472122__F1 Signaling pathways activated by FGF/FGFR 10818 6714 6772 PMC4473799__F3 Targeting signaling factors for degradation, an emerging mechanism for TRAF functions 7099 4118 7186 57506 7187 4615 7189 29110 5971 3661 5970 PMC4474537__F4 BMRF-MI: integrative identification of protein interaction network by modeling the gene dependency 2661 1942 658 30011 998 5295 11140 8440 1937 7532 572 10574 4654 140901 4087 4089 7533 10971 613 367 10499 5901 4171 1027 25 5764 1742 2534 7431 2907 5708 3315 1399 6300 5578 84966 1445 3276 3838 5829 387 580 4097 2079 9869 3837 5566 2057 3791 2771 7852 5788 4137 60 6714 5664 6464 6872 8648 6722 6882 7329 PMC4475926__F9 COX-2 increases insulin signaling by downregulation of miR-183 54487 1655 3667 29102 PMC4480226__F1 Immune Responses to HCV and Other Hepatitis Viruses 57506 7098 7187 29110 3661 5132 51284 PMC4483546__F1 Metformin on hepatocyte energy status and the mammalian target of rapamycin pathway, in turn affecting metabolism and inflammation 1950 5728 7248 7249 6009 64798 2475 1977 PMC4484471__F8 Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2 3082 1003 346389 7291 2638 PMC4485451__F1 BCR Signaling Pathway and Small Molecule Inhibitors of BCR Signaling 4067 5336 695 6850 29760 2475 930 PMC4487016__F2 Amino acid sensing in yeast and mammals at the vacuole or lysosome 84219 6396 79726 6395 4883 23677 4882 153129 6009 PMC4487016__F3 Molecular architecture of the SEA complex 6396 4883 4882 4827 84219 79726 9681 PMC4488716__F1 Signaling pathways of the endoplasmic reticulum (ER) stress response 22926 468 7494 83939 PMC4493053__F7 Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition 6608 6469 5728 5727 2475 2932 51684 4613 PMC4494966__F4 Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells 2852 4314 977 414325 55894 10382 6720 9902 4303 3394 26353 5176 56624 7075 9421 6876 4855 64092 54472 7292 7022 9344 81552 794 22900 8416 1366 84173 6678 2261 7103 7369 378884 51327 25797 PMC4495583__F3 Dendritic cell metabolism 7097 7096 7099 57506 7189 51295 29110 3661 3665 114548 3553 PMC4495933__F2 Roles of Wnt/Beta-catenin signaling during vertebrate heart development 55897 22943 1499 PMC4497751__F2 MicroRNA regulation of lymphocyte tolerance and autoimmunity 2549 26191 5163 695 5728 23035 7248 7249 572 2475 PMC4498560__F1 HPVs infect host epithelial cells (keratinocytes) by interacting with different cell surface receptors such as integrin and heparan sulfate proteoglycans (HSPGs) 1956 1950 2475 PMC4498940__F3 Changes in the pRb and p53 pathway promoting cell cycle passage in high-grade central chondrosarcoma, as found in the present and previous studies 595 1019 4193 PMC4503712__F3 Candida albicans proteins for metabolic pathway 128 4190 4191 48 PMC4503753__F7 EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer 4072 960 6657 79923 1499 2274 596 PMC4506441__F5 Distribution of target proteins on the compressed ‘influenza-related pathway’ 5340 1131 5336 7706 7098 7350 2932 958 3661 942 3569 4513 4284 8178 183 1129 1956 5972 5771 6774 1359 1636 5476 57486 5350 4311 290 1017 4012 5292 4843 PMC4506991__F7 Proposed mechanisms of bilirubin modulation of TLR4 signaling 7099 4615 405 196 1543 PMC4507501__F1 New targets in cancer cell metabolism are shown 5223 3418 3417 PMC4510836__F1 Complement cascade and its regulators 718 717 4179 727 1378 2271 966 729 735 730 PMC4511315__F1 Schematic diagram for signaling regulation of acetylcholinesterase (AChE) 43 1950 2247 PMC4512304__F2 Ramification of IFN signaling pathways leading to immunostimulatory and immunosuppressive regulation of macrophage polarization 3454 3455 3716 7297 10379 207 3659 4283 4599 PMC4515750__F1 Diversity and complexity of dicer dependent small RNA networks in animals 26136 29102 23405 192669 27161 PMC4515826__F7 Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity 5728 4036 472 4771 4744 4585 169044 26047 56979 84033 9745 55294 23499 673 7273 1499 91752 4292 114788 5927 89795 5518 10664 5314 5290 7157 999 54768 1769 3845 196385 4583 9699 2196 1387 7428 463 3815 23619 83872 2475 348980 6262 8701 84433 2042 7399 6261 53353 4035 8029 54880 9817 PMC4518158__F1 Unfolded protein response 22926 7494 83939 468 PMC4522054__F1 Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks 1401 10763 4282 7018 7412 1636 3479 4353 PMC4526101__F2 The systemic lupus erythematosus pathway in which HLA-DPB1, HIST1H4J, HIST1H2BO, H3F3C, H2AFY, H3F3A, HIST2H3D, HIST1H4D, HIST2H4B, HIST1H2BL and HIST1H4K are involved 4118 717 84324 114034 1431 613 324 7054 3586 PMC4526774__F2 Pim signaling in MM 572 4149 4609 7249 6009 1999 1977 PMC4529918__F1 An illustration representing microRNAs (miRNAs) and their targets involved in EGFR signaling pathway in lung cancer and anti-EGFR therapy 1956 3845 2475 4609 673 5728 2077 PMC4529978__F1 ROS-dependent cellular senescence pathways in MSCs 8091 23411 1786 1789 PMC4530868__F4 MicroRNA and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction 8717 1282 7186 7188 4313 7078 5728 5970 356 6774 6667 7422 PMC4531138__F2 miRNAs control inflammatory response in ECs 10365 8945 9314 23411 7057 7189 3654 6004 7046 5465 4087 7852 6387 2919 6347 PMC4532730__F1 Intercellular apoptosis-inducing ROS signaling 27035 4025 847 PMC4532730__F9 Catalase inactivation by low concentrations of photofrin-derived singlet oxygen requires an additional amplification step that is mediated by the FAS receptor and caspase-8A 4025 847 27035 PMC4533315__F3 ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis 1499 2932 6934 5290 6932 5295 10000 332 8503 208 5293 51176 5291 5296 5294 207 572 842 4609 5595 673 595 2353 5604 5594 5894 1630 836 3725 387 7046 5599 5880 4087 5900 5601 5881 4088 5602 5879 596 581 4089 4397 324 4436 387569 27040 2956 PMC4536527__F8 Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1A pathway in chondrocytes 7099 3091 3553 PMC4539521__F6 Changes in gene expression and MAPK signaling pathways in Cgasg1Δ and Cghal9Δ strains 11043 6588 998 2521 PMC4540028__F3 Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree 1652 4598 100 3652 PMC4541706__F1 The unfolded protein response 22926 7494 83939 468 PMC4542789__F3 Sub-network of genes regulated by E2F3, E2F4, and the E2F functional group 995 6502 4999 4436 50507 29028 894 4173 6118 9846 80139 4174 4172 10926 1894 1889 4175 9833 1537 9134 5046 4602 7083 8317 26271 993 9232 7272 7161 3925 55388 4176 5111 5888 890 7298 891 5933 4085 839 23089 PMC4544723__F7 Proposed schematic showing targets of EBN action in the insulin signaling pathway 3767 2645 3551 3643 5290 5594 PMC4544746__F7 STALK CELL PHENOTYPE DEPENDS ON INTEGRATION OF NOTCH AND SMAD1/5 SIGNALING CASCADES 3397 3280 3423 23462 PMC4544784__F5 MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis 914 920 952 8178 924 960 928 930 933 947 100133941 7054 945 929 7124 2056 948 2057 7173 923 PMC4546649__F6 Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse 6928 113220 192668 5314 5311 5310 PMC4547205__F2 Ingenuity pathway analysis comparing gingivitis to healthy subjects 57761 4899 3630 2303 10891 6720 3174 133522 PMC4553261__F1 Data slicing and pathway enrichment analysis 4513 351 100187761 6418 PMC4553756__F3 Delta-1-pyrroline-5-carboxylate synthase (P5CS) pathway 5009 435 383 4942 5831 5832 PMC4554827__F1 Core of the Hippo pathway 9448 4485 60485 9113 26524 55233 92597 374 51421 332 PMC4554827__F3 Function of nuclear and cytoplasmic Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) 10521 23054 1499 79577 PMC4555078__F1 RTK signaling pathways and representative regulatory microRNAs 1956 5728 619556 2475 1958 2353 3725 1021 1019 PMC4556222__F2 Androgen synthesis pathway 1583 1586 3294 3293 8644 3283 6715 1646 1645 9420 7366 PMC4556939__F4 Transcriptomic analysis of cyclic AMP response in bovine cumulus cells 2260 5156 2263 885 5105 7422 4215 7532 6774 1026 1326 5333 1462 2697 4843 4929 3164 5054 5327 5241 9510 3949 3091 6597 3037 4318 5730 6770 5155 5806 PMC4560923__F2 Yeast MAPK signaling pathways are associated to hypersensitivity to cell wall stress conditions 11043 6762 6761 998 84188 PMC4562315__F1 Emerging roles of YAP and TAZ in cancer 4771 4485 60485 9113 26524 92597 55233 51421 374 332 PMC4562806__F1 New immunotherapies targeting the PD-1 pathway 324 940 5728 10538 2475 PMC4563671__F8 Death-associated protein kinase 1 promotes growth of p53-mutant cancers 1612 7249 7248 PMC4568774__F1 Anti-tumor mechanism of combi-targeting molecule 7039 1950 1956 5894 572 581 7515 2067 PMC4570544__F1 The Clp proteases and chaperones in Plasmodium and the Plasmodium translocon of exported proteins 85457 8192 3550 PMC4571978__F1 A, diagram of the workflow of mitochondrial proteomic studies 6418 1506 22944 790 PMC4574248__F2 Signal transduction pathways and the oxidative stress response 11043 892 1024 9969 PMC4576203__F2 Participation of HPV oncogenes at different levels of Wnt/Beta-catenin cell signaling regulation 324 1499 2932 2305 7593 6477 7080 PMC4576950__F2 Processing of the Notch signaling pathway and the nuclear cycle 4851 5045 23013 388585 3280 23462 1024 PMC4581604__F9 Diagram summarizing the Rheb-mTOR signaling pathway and findings presented in this study 2932 6009 3667 PMC4582071__F3 Intracellular pathways to canalicular and basolateral plasma membranes 8647 5244 5243 1244 1048 PMC4582105__F3 Defects in ribosomal biogenesis activate p53 and other stress-response mechanisms 4609 27343 11201 4193 PMC4582667__F1 Phosphatidic acid: a new therapeutic lead to suppress hepatic glucose production 4018 10555 5091 PMC4586477__F5 Many signals overlap with PI3K/AKT/mTOR pathways in tumor-specific CD8+ T cells 2885 3611 5728 5163 84969 11140 7248 572 7249 4193 6009 79923 1977 PMC4587406__F1 Dysregulation of dNTPs in cancer pathogenesis and its targeted therapy 545 25939 983 PMC4588110__F1 PI3Ks signaling during G2/M progression and mitosis phase 983 5289 5347 324 PMC4589385__F1 Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer 3265 5894 56848 5604 5594 5579 9047 5335 5530 4773 5743 25759 5747 7422 3791 5829 998 9261 3315 6714 5295 5879 4846 10000 842 572 PMC4590607__F3 Functional architecture of AXAN 6010 2475 23710 1130 64601 9140 53917 89849 9474 10533 26276 11337 440738 9615 23192 55054 64422 23339 643246 65082 57617 11345 83734 9527 64400 27032 115201 55850 6786 58476 1892 440 2997 10056 6723 178 5563 51422 5562 11224 8661 6794 1650 51719 23521 9695 53632 10645 6185 57521 5564 10970 9024 6294 92335 9821 9667 9776 8408 9706 PMC4590620__F2 Alcohol’s effects on pro-inflammatory pathways in liver macrophages (i.e., Kupffer cells) 3929 929 7099 3553 PMC4592163__F1 Endoplasmic reticulum stress inducing autophagy 22926 83939 468 10533 PMC4592238__F10 Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro 5805 2695 130589 6908 PMC4593320__F2 Role of Bmi-1 in Ink4a/Arf Pathway 9055 1019 4193 PMC4593342__F1 Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy 79923 3214 1499 9242 PMC4595774__F1 Regulation of the Golgi via the GOLPH3 pathway 55204 64083 399687 PMC4599573__F13 Schematic diagram shows that PLB regulates the Nrf2-mediated oxidative signaling pathway and its downstream proteins NQO1, GST, and HSP90 in SCC25 cells.Abbreviations: ROS, reactive oxygen species; GST, glutathione S-transferase 9817 8452 4094 1728 PMC4599573__F5 PLB regulates death receptor signaling in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis 7124 355 8772 8717 1616 7186 331 637 56616 317 839 1676 4000 1677 6093 2620 3984 397 PMC4600536__F3 Role of IGF-I Signaling in Muscle Bone Interactions 3479 2885 2475 2353 3725 572 PMC4600637__F1 Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia 396 998 10602 23580 5058 5062 5063 3984 3985 PMC4600855__F1 S-nitrosylation in TRAIL/DR4 and FaL/Fas signaling pathways 355 7528 8772 841 637 836 842 PMC4600855__F2 S-nitrosylation in classical TNF-NF-kB signaling 8717 7186 81858 8772 841 PMC4600855__F3 S-nitrosylation in TNF-JNK-AP-1 signaling 8717 7186 2353 PMC4603759__F6 Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism 150763 57678 50484 6241 6240 2729 2937 2592 7360 PMC4604214__F3 Key Figure: Developmental and Disease-associated Pathways Regulated by Chromodomain Helicase DNA Binding Protein 7 (CHD7).CHD7 can affect the activity of several signalling pathways that control development 6899 10371 8085 7403 4086 55636 6657 2255 5015 4613 2737 182 2253 2637 PMC4607752__F5 BaP effects on the expression of BaP marker genes and genes involved in the AHR signaling pathway 84034 2263 2019 2938 30811 4625 4780 196 351 10864 26960 6591 4353 6774 8861 3304 3303 7057 7077 2729 7295 2261 63874 10659 301 PMC4610178__F4a Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise 4193 7157 1029 1026 1021 1019 1017 595 898 5925 1871 PMC4610744__F1 Genes and pathways identified from GWAS and/or studies of monogenic allergy-related diseases 5336 6774 9173 6778 5238 3558 3560 3570 3596 90865 604 81704 7454 23406 2625 4773 6095 64375 50943 3169 4609 51621 4088 7046 7048 2615 222256 1041 1828 2312 11005 85480 4026 440854 5017 7096 81793 10333 5734 PMC4613517__F1 Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress 8452 9978 8454 4094 9817 PMC4614824__F1 Cystathionine Gamma-lyase (CSE), the biosynthetic enzyme for cysteine is depleted in Huntington's disease (HD) at the transcriptional level 875 4810 6874 6667 PMC4615001__F2 Mitoribosome assembly lines 26164 92170 29960 4553 387338 10939 55794 6687 100196919 79863 PMC4618289__F1 MTOR pathway as a central signaling pathway causing malformations of cortical development and epilepsy 5728 7248 7249 6009 10641 8131 PMC4618842__F1 Pathogenesis of Muscle Wasting in Cancer Cachexia: Targeted Anabolic and Anti-Catabolic Therapies 2475 1998 1977 3479 PMC4620719__F2 Cross-regulation of intracellular membrane-associated proteins and microRNAs in B cell differentiation 407050 407051 55054 9474 9140 PMC4621105__F2 Common cellular processes important in coronavirus replication 8559 56342 1655 10465 1653 3189 3178 5431 6632 3191 988 24148 51503 5356 1975 2077 129787 6201 3646 381 1915 25807 8876 6224 6319 3755 7122 51226 488 8729 8665 51187 440026 23481 79589 3838 7415 595 7329 9978 10213 9040 6059 PMC4621741__F1 Mutant SPOP promotes genomic rearrangements within chromosomes 6885 8405 1105 PMC4623399__F6 Summary of protein and metabolites data at t = 8 h 2597 5132 4191 717 PMC4625495__F1 Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury 4099 3569 387 PMC4626177__F7 Pathway network analyses on upregulated genes from late stage (stage IIIc) TNBC 5076 4488 1950 51176 5865 6615 6616 5602 3209 PMC4628672__F3 Pathways analysis of the proteins listed in by means of the Ingenuity software 596 11315 7417 637 842 317 4001 PMC4630209__F2 KIT-mediated signaling events 3815 4067 2534 695 9846 2885 PMC4630409__F1 Schematic overview of TLR and NLR signaling pathways 7099 7097 7100 64127 4615 3661 54106 51311 51284 7098 3665 PMC4631295__F2 Canonical Wnt signaling pathway 1499 324 999 PMC4632296__F8 A working model depicting that RILP interacts with RalGDS to inhibit Ral pathway 5898 5900 83547 PMC4632709__F3 Single network includes most splice regulatory genes dysregulated in MS 9169 6434 100133941 9477 7919 51003 6426 3181 4154 55090 23013 84246 3187 4780 5093 29079 5728 219541 1479 4609 6837 8666 54797 891 649299 5434 5439 3189 91746 PMC4632748__F7 Possible involvement of candidate microRNAs in tamoxifen resistance pathways, based on the present literature search and IPA analysis 1956 7078 3479 6714 27043 55824 1021 596 1591 3211 3169 442909 3198 6935 55818 PMC4632830__F1 Heme biosynthesis pathway (in red) connects with glucose (in green) and glutamine (in blue) metabolic pathways 7390 7389 2235 1371 PMC4633016__F3 Schematic diagram showing the convergence of WNT and NOTCH signaling onto cell cycle regulation 8321 1956 1499 4851 51176 3516 595 PMC4633218__F7 Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet 23411 79602 355 PMC4635001__F1 Structural Characterisation of FabG from Yersinia pestis, a Key Component of Bacterial Fatty Acid Synthesis 2194 2242 2271 2233 355 383 2091 PMC4637163__F2 Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer 6774 8205 6347 6348 6351 PMC4638034__F3 Signaling pathways 5091 4522 1956 635 6774 1786 PMC4638170__F3 Gaining insights into diabetic cardiomyopathy from Drosophila 6345 6717 355 6950 9575 PMC4646237__F9 Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway 3479 3667 5209 2147 PMC4646463__F1 Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling 1950 1956 5727 6608 64399 2475 51684 6194 374 PMC4648381__F2 MGMT and other DNA repair mechanisms deal with DNA damage produced by the alkylating agent TMZ in cancer cells 4255 4350 8178 8505 10038 PMC4648419__F5 Enriched pathway of Integrin (A) and migration (B) 11117 7094 3672 3679 811 3678 4638 3507 7414 2317 7431 4637 7052 2934 4627 4629 2316 87 7531 7184 2923 81 5053 5339 7430 10398 3309 2539 821 7534 9601 348 2950 142 9961 PMC4650145__F7 NeurimmiRs were found targeting multiple molecules of the integrin and NFKB pathway 958 5878 23011 7186 998 3611 7187 695 10910 10392 142678 1387 PMC4652019__F1 TLR4 signaling in obesity 7099 4615 4218 PMC4657330__F8 Rac1 activation and Wnt synergistically enhance Beta-catenin transactivation in the canonical Wnt pathway 5879 2932 324 PMC4661576__F1 The fate of chemoresistance in triple negative breast cancer (TNBC) 9429 581 4292 4436 PMC4666325__F2 BCR signaling and downstream pathways 613 2475 4067 6850 695 84433 8915 10892 PMC4669099__F3 Targeting BCR signaling attenuates homing, survival, EMDR and MRD of malignant B cells 613 29760 973 974 6850 695 4067 PMC4673168__F5 ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma 374 673 2885 4763 3815 2475 2767 PMC4673612__F6 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks 10401 1500 10006 2697 7529 3716 8976 9047 6457 5584 5590 3717 5801 5898 673 8625 28964 5900 51196 3265 5747 5578 1432 6197 5580 5921 6667 2886 3727 2060 868 7141 1950 5829 375033 7534 1050 4609 1051 5170 29924 4790 2319 3092 5970 3065 10253 5899 50807 6456 PMC4673677__F3 Surviving at a distance: organ specific metastasis 6678 51129 4513 4313 3487 7412 PMC4674888__F10 Cell cycle Role of SCF complex in cell cycle regulation which is the third scored pathway map in MetaCore enrichment analysis results 4088 6502 324 6500 997 8454 9978 5347 1019 25859 545 472 PMC4676172__F2 Wnt/Beta-catenin signaling and directly related pathways affected by genetic-driven and/or gene expression activation or suppression in primary and/or recurrent tumors of 4 HCC patients 6423 11197 6424 4035 4040 4041 999 6714 1499 207 5300 208 3611 324 10454 4193 1029 51701 3052 6659 55553 1869 6662 4316 960 6925 PMC4677515__F1 Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos 7045 2660 551 10631 153129 4893 112 64805 9892 2788 8642 55004 2792 2357 526 5608 23551 64121 1412 10670 5464 7273 4191 9595 226 10321 167 10873 3028 50 2665 5837 10971 64770 7316 7384 3872 487 6193 3306 55803 79676 26330 4913 50809 7341 3146 1414 100271849 4831 3191 10492 79026 84193 25926 523 1213 2782 54805 270 3329 6674 844 203 1937 7200 6369 6367 6346 6361 6372 5317 1230 64581 3579 23557 3856 54903 3636 3855 140807 7398 7345 3851 27130 4867 PMC4678324__F3 Cell-intrinsic versus cell-extrinsic control of metastatic progression by miRNAs 5894 571 8091 3485 26207 10461 3479 2621 3480 55466 348 4035 PMC4679438__F2 mTOR and its tight regulation for iNKT cell development and effector function 912 2534 5163 10125 6009 7248 PMC4679489__F2 Critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review 7097 7100 7096 10333 7099 4615 4118 3654 7189 7098 54106 51284 23118 51135 7187 257397 29110 85451 3661 3665 PMC4683444__F4 Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity 356 1676 329 598 596 4803 572 3562 1439 581 472 7157 1437 10000 4914 PMC4685420__F1 Schematic summarizing some of the genes and pathways known to influence c-Myc cap-independent translation in multiple myeloma (MM) 3479 3569 2475 3178 6230 PMC4687464__F2 Wilms' tumor 1 (WT1) contributes to metanephric mesenchyme self-renewal and its differentiation 168667 7490 3237 10736 652 655 6299 5076 7484 2619 54361 3975 PMC4693579__F2 GLP‐1 and Wnt signalling in the regulation of bone formation (A) In the inactive state of the Wnt/B‐catenin pathway, Wnt is inhibited by a decoy receptor sFRP, where as its co‐receptor LRP5/6 binds to inhibitory protein sclerostin or Dkk 10023 324 1499 4041 50964 4023 4040 PMC4694980__F2 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage 4151 250 1992 4705 5269 PMC4694982__F9 By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis 4072 2353 3725 PMC4695847__F1 Functions of mono-ADP-ribosylating ARTD (ADP-ribosyltransferase diphtheria toxin-like) enzymes and of mono-ADP-ribosylating Sirtuins in signaling 2932 23409 51548 6778 405 9760 196 3565 PMC4696776__F2a Insights into acute myeloid leukemia via single cell network profiling 9429 7852 5336 5266 PMC4698020__F8 Schematic diagram showing the inhibitory effects of triptolide on oxaliplatin induced upregulation of nucleotide excision repair pathway 7508 2067 7507 PMC4698399__F8 Processes responsible for the synthesis, trafficking, and degradation of membrane proteins 8573 30846 8411 10890 55667 10938 64284 30845 4074 7879 30844 1956 338382 3920 PMC4698487__F2 Perspective on targeting copper metabolism for the treatment of hepatocellular carcinoma 540 9973 475 10063 6647 619501 PMC4698658__F1 Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers 55364 857 948 6720 57103 3991 11343 2194 30 2475 126129 9997 4609 5163 3091 PMC4699037__F1 Signaling affecting stem cells identity and their interplay with chromatin 2247 3976 4838 652 2932 4087 4088 6774 2249 9314 79923 6657 26136 PMC4701041__F7 Proposed model for a critical role of ERA in E2-induced cholesterol gallstones 3949 5244 8647 64240 PMC4702820__F4 Gene–gene network category and pharmacological category 3423 6342 130367 85329 65084 55825 5095 7069 100187761 PMC4703717__F1 Synthesis and immunomodulatory effect of gangliosides 6489 51083 941 958 920 PMC4705542__F5 Schematic summary of the proposed photoneuroendocrine control of VGF expression 23237 7425 1382 1734 1735 PMC4706579__F3 IL-23/T17 pathogenic axis is an important therapeutic target in psoriasis 149233 6774 10318 5966 4792 PMC4708174__F1 PI3K–AKT–mTOR pathway and drug targets 7039 2885 3667 7249 7248 5728 5163 6194 PMC4711368__F4 Signaling pathways of cytokines in GnRH neurons 1270 3553 3976 PMC4711826__F7 Molecular explanation 10413 7042 7043 6696 4087 4088 4089 7046 PMC4714660__F1 Human dendritic cell (DC) response to Toll‐like receptor (TLR)2/3 adjuvants 100187761 7098 925 7096 7097 3146 7099 4615 7100 29110 55509 10333 3661 51284 51311 54106 81793 PMC4715152__F1 TRAF2 signal pathway networks 7124 4055 958 8717 7187 7186 PMC4715152__F3 WWOX/WOX1 and signaling networks 3082 8692 51741 2066 860 PMC4715896__F1 Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis 27235 10229 51805 PMC4716813__F2 Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? 183 1636 59272 PMC4717889__F1 TLRs play critical roles in gastrointestinal inflammatory disorders at the mucosa 929 7097 59307 7099 7096 10333 6761 114609 4615 7098 7189 54106 51284 29110 3661 3725 6095 1956 1499 PMC4720882__F1 Alcohol and HIV-related neuroinflammation and cytotoxicity contribute astrocyte cPLA2 activation into the limelight 4513 1571 3553 7124 PMC4724815__F6 Long non‐coding RNA urothelial cancer‐associated 1 promotes bladder cancer cell migration and invasion by way of the hsa‐miR‐145–ZEB1/2–FSCN1 pathway 6935 9839 6624 999 1000 PMC4725058__F2 Length of interaction alters the activation of specific transcription factors 3932 998 7535 6786 85451 3725 2353 27040 920 940 PMC4730344__F2 Cell death pathways after irradiation 8772 581 3397 317 596 1017 1021 1019 5925 PMC4731263__F3 Mapping Proteome-Wide Interactions of Reactive Chemicals Using Chemoproteomic Platforms 7920 23259 10449 PMC4734677__F6 Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye 54567 4851 7424 PMC4735260__F6 Transcriptional regulation of mitophagy 468 139341 6667 10370 664 1869 PMC4736967__F1 Wnt/Beta-catenin signaling in ASDs 847 4040 4041 324 7249 7248 PMC4738349__F10 Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis 8737 11035 197259 PMC4741712__F2 An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer 11244 8644 3627 3659 6233 3665 3276 55284 57062 3620 3458 6772 5970 3725 3459 3660 4790 8554 3661 PMC4741712__F4 An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer 3932 8517 10892 2534 10671 7323 84433 7409 25780 51550 7324 7456 868 836 8615 4067 4205 148581 23321 3385 51619 7170 5588 3093 55284 7328 140885 1147 5295 10477 6402 8915 2915 5170 7325 7322 7532 5584 7334 207 3667 6886 7321 11015 10273 5590 1836 53917 3778 3628 3978 PMC4741978__F3 SNP-SNP interaction analysis of NFKB signaling pathway on breast cancer survival 7186 7187 4791 4790 PMC4742115__F5 Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development 4280 348 29121 6422 1947 6943 7052 6476 PMC4742123__F2 Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer 6714 367 4281 PMC4742232__F6 Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERAlpha-ΔNp63-Integrin B4 Signaling Pathway 3691 6469 2736 652 PMC4743039__F8 Bidirectional synaptic structural plasticity after chronic cocaine administration occurs through Rap1 small GTPase signaling 387 4118 6722 5908 2475 PMC4743890__F1 Neural circuitry and immunity 43 4922 7099 PMC4744573__F1 Standing your Ground to Exoribonucleases: Function of Flavivirus Long Non-coding RNAs 129563 167227 54464 PMC4747375__F7 Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma 374 1956 3383 PMC4747886__F4 Molecular mechanisms of survivin in tumorigenesis 4193 1499 1019 4087 4088 4089 6774 PMC4753150__F4 Vitamin D and Calcium Regulation of Epidermal Wound Healing 1499 5469 7421 6925 991 960 26292 83595 11166 4487 8313 2877 6422 6698 11197 PMC4754913__F2 Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor chemoresistance 10803 5728 1499 2475 PMC4763967__F1 MiRNAs biogenesis pathway 22937 5901 26523 192670 27161 192669 PMC4764462__F2 Transcriptional control of cardiac fibroblast plasticity 7220 7225 7222 1499 4087 4088 387 688 28999 6722 PMC4765526__F1 Cartilage matrix homeostasis is regulated dynamically by the TGFB signaling pathway 4086 4087 4090 4088 4089 PMC4765532__F2 BMP signaling pathway including microRNA regulation 100616250 650 4091 4090 4086 4089 PMC4766460__F2 Plasticity of gene‐regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators 6658 6736 22943 5729 2254 284654 6662 7536 30812 1499 1761 2099 2100 269 PMC4768065__F7 Proposed model of the involvement of Spry2 and Spry2 siRNA in TLR, IFNG receptor, and growth factor signaling pathways for suppression of M1 polarization and enhancement of M2 polarization in macrophages 7097 4615 10253 383 3458 1950 PMC4771746__F2 Example pathway (Alzheimer's disease) overlaid with gene expression data from BBB cell line 102 322 351 23621 2597 6389 23385 3416 4311 4023 348 54205 572 836 842 355 841 8772 637 317 487 6263 2081 22926 4842 4137 7124 2932 3553 840 PMC4772349__F2 Candidate driving genetic alterations and their druggability in AYA cancers 4763 8312 4487 2195 5922 1031 1499 1021 1019 4193 5428 5426 3980 1642 5728 2475 238 PMC4772995__F2 Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients 10301 23420 10634 56926 4938 10589 1777 9789 55160 79132 8625 3135 PMC4774216__F1 RhoA/Rho kinase in spinal cord injury 4099 4018 84894 718 387 6093 9475 5728 PMC4775314__F3 Untapped Potential of Tyrosine-based G Protein Signaling 7099 6774 6476 PMC4777718__F2 A view of L-homoserine biosynthesis pathway page 9118 5901 100187761 PMC4777846__F7 Schematic diagram of LRP1/Wnt5a-dependent inhibition of intracellular cholesterol accumulation 4035 7474 19 57552 9619 PMC4778253__F4 Mesenchymal and endodermal signaling events 9241 6657 2049 2255 7482 7472 6469 PMC4784721__F1 Major AGTR1 signalling pathways linked to cancer cell proliferation, angiogenesis and EMT 1956 2885 10892 8915 PMC4785274__F1 H2S biosynthesis, functions, and metabolism 875 847 4357 PMC4786758__F3 Position of miRNA targeted genes (red box) in endometrial carcinogenesis pathway (KEGG) 5728 5290 10000 572 3611 1956 3845 6654 2002 8313 324 2932 7157 2064 PMC4788885__F5 Wnt signaling pathway 51701 4089 324 9350 6500 6477 8454 9978 23002 9475 387 PMC4789422__F7 Carcinogenic mechanisms from normal to stage 1 bladder cancer cells (a), and from stage 1 to stage 4 bladder cancer cells (b) 6613 7316 55658 811 7124 3300 23197 6224 5718 1894 5708 PMC4790585__F7 General role of the proteins used for in silico experiments 85409 324 2932 1499 999 PMC4791423__F3 Crosstalk between the TLR signaling pathway and the Notch pathway 3280 23462 7124 PMC4801359__F2 miTALOS v2: Analyzing Tissue Specific microRNA Function 3630 2335 2147 1793 324 6010 9572 693156 PMC4804208__F6 Metabolic flux profiling of MDCK cells during growth and canine adenovirus vector production 5091 4118 11113 PMC4807419__F1 The transcriptional and posttranscriptional regulation of LDLR expression 255738 3949 22937 PMC4807884__F1 Regulation of SMN2 gene expression in SMA 4280 6607 5618 3717 PMC4808550__F1 Thyroid hormone-signaling pathway 3091 6714 6957 1499 2475 PMC4811429__F6 Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes 6469 64399 156 409 51684 2932 PMC4812115__F5 Most correlated signaling pathway was the rheumatoid arthritis pathway (http://www.kegg.jp/kegg-bin/show_pathway?map05323) 2920 3458 9317 3569 1514 1513 PMC4813636__F1 Direct and indirect inhibition of MYC 8295 4149 4609 4691 23476 PMC4815360__F3 Schematic diagram illustrating synthesis of ET peptides and interaction with receptors 5045 1889 1909 PMC4816150__F2 Adiponectin signal transduction pathway implicating a crosstalk with the insulin signaling pathway 26060 2475 3667 8660 PMC4817280__F2 Partial biosynthesis pathway for major brain gangliosides 8869 6483 6489 PMC4817351__F8 Molecular pathways of proliferation, survival and senescence 4914 6098 5979 238 1029 5728 1021 1019 2475 4193 1017 PMC4818686__F4 Rho Family GTPase signaling pathway alterations in adenoid cystic carcinoma 6010 85502 6249 2670 23191 100187761 PMC4819171__F2 Transcriptome sequencing reveals e-cigarette vapor and mainstream-smoke from tobacco cigarettes activate different gene expression profiles in human bronchial epithelial cells 2885 6722 2316 7186 1616 4149 23118 51295 100187907 1431 8544 PMC4822853__F3 Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis 3569 3565 246778 11009 3458 PMC4826689__F1 Canonical Wnt signaling pathway (Beta-catenin-dependent Wnt signaling pathway) 4041 22943 4040 2932 8312 324 1499 PMC4829549__F2 MET signaling pathway 3082 2885 6714 2549 6774 2475 572 4193 PMC4829553__F4 Genes positively and negatively connected to the expression of Egfr in the mouse liver 5902 8517 3550 10342 1956 1874 10952 27023 732 23471 3190 89886 6476 PMC4832872__F3 Inflammation in gastric cancer: Interplay of the COX‐2/prostaglandin E2 and Toll‐like receptor/MyD88 pathways 3146 7097 929 4615 8842 960 6657 124056 27035 6348 6774 PMC4833611__F1 Nurr1 pathway and Nurr1‐based therapies for Parkinson's disease 2668 5979 1499 822 6667 PMC4835424__F1 Plausible biosynthetic pathway leading to atisine in A 2597 5132 283871 4598 3652 PMC4835676__F5 An integrated model of the TLR signaling pathway modulated by the multifurcating motif of poeModules M14-M18 3440 3456 5066 114609 4615 7189 3716 23118 257397 7187 29110 4790 5966 6773 6772 3394 3665 3661 7124 64332 1616 3669 1462 9249 161742 5209 23589 11176 2117 10938 1399 9853 8767 6532 4939 6672 57458 7050 57823 PMC4838319__F2 De novo synthesis of CoA is a highly conserved pathway that consists of 5 enzymatic steps: pathothenic acid phosphorylation, cysteine conjugation, decarboxylation, conjugation to an adenosyl group and phosphorylation 79717 60490 5471 PMC4846832__F6 Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury 4615 3654 7099 PMC4847623__F1 Sphingolipid biosynthetic pathway 5004 5005 4284 1442 PMC4848843__F2 Regulation of lipid metabolism by BAF60a and BAF60c in periportal and perivenous hepatocytes, respectively, under the control of nutritional and hormonal signals 23411 5465 7391 355 PMC4851740__F3 Schematic model of signaling pathways implicated in tumor cell VM 1003 4838 1969 4855 7291 7018 4323 4313 PMC4852766__F6 Proposed models that potentially link collagen VI myopathy and circadian genes 2309 2475 207 22863 3091 9575 PMC4858804__F1 Pathway for yeast cytoplasmic translation initiation 1998 2001 1983 PMC4858804__F7 Recycling and regulation of eIF2 by eIF2B 1998 2001 1983 81606 PMC4859429__F2 Classical and non-classical roles for pre-receptor control of DHT metabolism in prostate cancer progression 1586 6770 3293 3294 8644 6715 6716 1645 8630 1646 3028 7366 7367 PMC4859887__F2 RTKs mediate DDR through canonical AKT and RAS pathways 545 142 572 7515 472 11073 672 PMC4859887__F3 Some RTKs regulate DDR through specific canonical pathways 1956 5111 7515 2067 1017 983 PMC4860420__F2 Reelin signaling mechanisms in brain development and function 1600 2534 6714 1398 2475 7436 PMC4861839__F1 Inositide signaling pathway and target agents used to treat gastric cancer and colorectal cancer 5728 5163 7249 7248 2475 253260 PMC4862319__F1 Simplified schematic of signaling junctions that integrate the recognition of pathogen, host or environmentally derived DAMPs and dAMPs by their cognate receptors 3146 7097 7099 3428 115004 114548 9447 22861 54106 7098 51284 57506 4615 29110 3661 3665 3603 3553 PMC4865504__F1 Human and rodent adrenal steroidogenic pathways 3284 6770 1584 1585 3949 PMC4867368__F7 The mechanistically diverse PF03099 lipoyl metabolism enzymes 4018 3988 3989 340654 149998 PMC4868689__F7 Protein kinase D2 contributes to TNF-Alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3B/Beta-catenin pathway in hepatocellular carcinoma 5311 2932 1499 PMC4871423__F6 Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression 367 2624 595 9020 860 4601 9360 25942 2833 PMC4872111__F1 Genes involved in CRC pathway 7976 8323 324 1499 2932 1855 1857 6655 572 842 836 6010 5900 1630 26060 4436 4087 4088 4089 7046 581 596 PMC4872805__F2 Sirtuins as regulators of metabolism and healthspan 23411 7351 200186 2308 5465 23410 6648 3158 3418 4704 9611 4899 PMC4876452__F5 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis 7096 7099 64127 4938 7189 6850 4939 6041 3661 7124 7097 6955 4615 10392 PMC4876452__F6 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis 81793 91662 6955 171389 58484 4049 4353 55655 338321 10392 7099 3717 64127 338322 338323 147945 114548 3553 2885 3654 958 PMC4876452__F7 Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis 8772 1616 8717 10010 7186 331 56616 54205 27429 317 836 839 840 1676 6709 6093 84875 4000 3984 1677 2620 397 56829 355 841 843 637 22985 PMC4876997__F6 Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15 3549 6469 5727 860 2736 2735 1385 7421 1958 5573 PMC4877629__F3 Genetic networks generated from the differentially expressed genes from adipose tissues 4057 50619 3687 3676 2243 3683 3672 59307 3689 7408 4064 939 23075 397 5880 257144 9844 9047 1795 2175 5074 54751 PMC4882250__F5 Characterizing strain variation in engineered E. coli using a multi-omics based workflow 10249 6120 1431 5183 197257 PMC4882277__F7 Proposed mechanism by which miR-21 links hepatic lipid accumulation and the development of cancer 26959 595 891 6720 PMC4882535__F5 Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine 3576 7422 3909 3934 1287 2335 50855 7430 56288 60 5962 4478 5584 5578 387 842 836 5595 5241 81027 PMC4885164__F1 Role of stromal cell-derived factor 1A pathway in bone metastatic prostate cancer 58191 7852 8763 9242 PMC4885841__F6 Schematic diagram demonstrating the immunomodulatory and therapeutic effects that grafted stem cells exerted on the recipient upon transplantation 7099 7098 9242 4803 2668 1950 627 PMC4885862__F4 Survival strategies used by E 6868 5771 4734 5045 7097 7099 1314 3916 10487 PMC4885935__F1 Roles of sclerostin, Lrp4 and Wls in Wnt/Beta-catenin signals in osteoblasts 4038 4041 4040 324 1499 PMC4887211__F9 Proposed working model for Fbxo21-mediated innate antiviral response 4738 6500 9978 23014 4217 PMC4887869__F4 Hydrogen sulfide metabolite trimethylsulfonium is found in human urine 2937 847 875 6007 PMC4888213__F3 Multiple somatic alterations in components within the same pathways 22943 27123 79633 5728 324 8312 2475 7157 5925 2064 6416 2099 595 3635 472 1029 PMC4889216__F7 Mitochondrial stress induces chromatin reorganization to promote longevity and UPRmt 10873 4200 4199 PMC4890029__F9 MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells 993 891 1869 PMC4890468__F2 The mammalian target of rapamycin (mTOR) signaling pathway and crosstalk with the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway 1956 3667 5728 4763 23612 7249 7248 4609 PMC4890577__F1 Bile acid signaling in murine hepatocytes 9294 1958 3383 PMC4890635__F3 SOX9 is downstream effector of ERG and AR in TMPRSS2:ERG fusion-positive PCa 1499 367 6662 3169 2078 PMC4890907__F3 Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance 355 7038 5105 PMC4891268__F2 Cell-cycle entry regulated by a network of protein regulators 7249 7248 2475 1021 1019 PMC4893201__F1 Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes 10135 23411 51548 3417 3418 PMC4896088__F1 Nodes of therapeutic blockade in the PI3K and other signaling pathways that synergize with BET inhibition 5728 8821 3667 23678 5163 4193 4609 PMC4897783__F8 Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4 27121 1499 4041 PMC4899619__F2 Multiple TGFB signaling pathways 7939 126669 2885 387 156 2475 1019 4092 PMC4899619__F3 TGFB and tumor suppression 1874 3398 1019 1021 1869 317 56616 1616 90427 PMC4899745__F1 Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase 2819 2820 622 127 PMC4900191__F2 Regenerative Medicine: Charting a New Course in Wound Healing 1540 23118 10454 4609 920 5626 PMC4900455__F2 Reciprocal antagonism by TLR4 oncogenic and TGFB tumor suppressor pathways 10643 10413 79923 4088 6774 PMC4905167__F1 Novel targets for ATM-deficient malignancies 2177 675 6741 472 142 PMC4905215__F1 Endothelial-specific loss of GRK2 impairs maturation and vascular remodeling in adult and developmental angiogenesis 156 7040 4090 4086 4089 PMC4905265__F1 Schematic description of multiciliogenesis 4163 387 2316 PMC4905266__F1 Intersection between the Ras and the SUMO pathway in cancer 2885 10055 2002 PMC4905289__F2 TGFB signaling 124540 4089 7048 7049 3309 6997 PMC4905414__F1 Simplified model for phosphatidylserine receptor-mediated efferocytosis 2621 124599 6850 146722 11314 PMC4907806__F3 Exercise-Driven Metabolic Pathways in Healthy Cartilage 7006 100124696 4117 5478 572 PMC4911209__F1 Complete vs 999 1003 6935 9839 PMC4911353__F5 Interaction and expression pattern of SDEGs involved in canonical interferon signaling pathway in Mtb-infected mouse lungs with or without CC-11050 treatment 3458 6890 4938 6772 5696 3437 6773 8651 10379 3717 3430 581 3455 8519 10581 8554 PMC4914023__F1 Melanosome biogenesis is a typical model for studying LRO biogenesis 7306 9367 23682 10981 6845 PMC4914571__F5 Gene of the month: SMARCB1 1499 6598 990 4609 PMC4915141__F7 The biologic role of TRIM11 in lung cancer 81559 207 595 5111 999 PMC4915230__F1 Cell signaling pathway through which DD complex elicits a balance between survival and programmed cell death 7124 23118 257397 8717 8737 1540 7186 11035 8772 PMC4917709__F2 Negative modulation of EMT by sirtuins 999 4089 1499 22933 23409 4316 PMC4918232__F1 Antigenic stimulation of the BCR recruits CD79a and CD79b, and activates SYK and LYN kinase, resulting in the phosphorylation of cytoplasmic ITAMs on the immunoglobulin domains of the receptor 613 4067 695 6850 2475 6348 6351 PMC4918247__F1 HGF/c-Met signaling cascades.Notes: Upon binding of HGF to its receptor c-Met, c-Met is dimerized and activated by phosphorylation of Tyr 1234 and Tyr 1235 residues 3082 2549 6774 2885 2475 5894 5879 998 PMC491841__F1 Consensus model of the cell cycle control mechanism in budding yeast 324 999 991 10276 10518 375757 PMC4918597__F2 MiR-548, miR-27, miR-346, miR-218, miR-34a, miR-21, miR-22 and miR-29b promote the osteogenic differentiation of mesenchymal stem cells through Wnt/catenin, Notch, TNFA, TGFB/BMP signaling pathways 324 6423 3280 27123 2932 4853 1844 1499 860 PMC4918724__F5 Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis 4519 4537 4539 4538 4541 4692 4709 4710 6390 6391 6392 6389 4513 4514 10063 PMC4919052__F10 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq 1906 11009 3091 2735 3146 3659 2309 2308 3664 2033 3169 3553 3725 1959 1052 4780 4790 1051 604 405 5081 7040 29108 5966 5970 6347 4089 6597 3458 6667 6688 3456 7538 6772 7494 6774 6773 59067 3567 9518 4282 3952 3586 PMC4919473__F7 Inhibition of LINE-1 retrotransposition by the SLX4com prevents pro-inflammatory signaling 84464 80198 146956 PMC4922205__F2 BCR-ABL1 Signaling Network 8161 613 9846 3717 2475 6502 PMC4922502__F2 Actionable drugs in proliferation pathway that have been evaluated in BRAFmut CRC 2475 324 2885 673 1499 PMC4926373__F1 Schematic overview of DNA damaging agents, radiotherapy, DNA damage, the cellular response upon DNA damage, genetic variation, epigenetic regulation and cancer therapy response 3014 142 5888 672 545 472 PMC4926504__F1 Signaling mechanisms of epidermal growth factor receptor (EGFR) transactivation in renal fibrosis 1956 6714 4087 4088 PMC4927194__F2 Diverse extracellular signaling pathways are regulated by A disintegrin and metalloproteinase (ADAM)-mediated shedding events 102 6868 7039 374 1950 685 1839 3084 2069 999 7412 54567 28514 182 960 3713 PMC4928883__F3 Fundamentals of cancer metabolism 3099 2539 4522 2597 6470 26227 55902 6472 5091 441024 10797 47 2271 3418 3417 2744 PMC4930294__F2 Signaling pathways important for stem/progenitor cells regulation 84133 102 6047 6104 8549 474 324 PMC4931107__F1 snR81 box H/ACA RNP-catalyzed pseudouridylation 55651 55505 2638 54433 PMC4931665__F1 NFKB signaling consists of two main branches: canonical and non-canonical 7124 3845 958 4055 5971 960 4318 6387 PMC4931673__F3 Circuitry of amino acid signalling to MTORC1 23677 57600 201163 64223 375 2475 7249 7248 51256 6009 5861 PMC4931992__F7 Model of regulatory loop between Shh, IRS1, YAP, and YB1 3667 3481 6469 PMC4933215__F2a Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities 7099 4790 3091 3458 5604 8569 7428 9978 8453 3480 5293 1978 1977 2064 596 5295 5296 6194 8503 1026 207 2475 208 1027 817 5336 1387 818 7037 7422 PMC4935227__F2 WWOX regulates multiple signaling pathways 7124 6469 6608 51741 2735 1856 6714 860 2066 PMC4935337__F6 Proposed model for the action of KP-A021 on the RANK signaling pathways in osteoclast differentiation, bone resorption, and cytoskeletal rearrangement 7186 7189 6714 23118 10454 4772 PMC4937730__F1 Human polyamine biosynthesis, metabolism and transport and the methionine salvage pathway 6723 262 4507 6611 857 6520 PMC4938033__F3 Enhanced Ca2+ and ROS levels in cardiac hypertrophy 5350 6262 2626 PMC4939711__F3 Complex, compartmentalized pathways of NADPH production 57103 2147 4609 6472 6470 10797 4522 441024 PMC4939890__F2 Pathophysiological mechanisms involved in bicuspid aortic valve (BAV) 89780 4041 860 4851 652 650 6662 387 PMC4940573__F1 Strategies for modulating the BMP pathway 57154 4090 4086 PMC4940708__F8 Mechanism of the disease-modifying effect of P021 in AD 627 351 2932 PMC4941544__F2 Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data 1499 1630 324 4087 4089 387569 572 842 3725 6010 836 7046 2956 581 PMC4941544__F3 Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data 572 10928 1950 6774 4089 675 7046 PMC4943290__F1 Agents acting on the renin–angiotensin system pathway ©PharmGKB 1636 183 5972 59272 1511 4311 1215 4142 186 185 623 10159 624 5594 4846 7040 4306 PMC4943346__F1 Destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma 1499 324 999 PMC4944499__F7 CRT-knockdown correlates with the modulation of p53 and MAPK pathways 472 4193 5608 5599 5268 27296 PMC4947675__F1 Non-canonical autophagy in the clearance of dead cells 7939 8408 7405 10533 9474 PMC4949115__F2 M2a polarization 3716 3718 7297 3717 3662 PMC4956504__F1 Androgen pathway and genes involved in androgen biosynthesis and metabolism 3283 3294 6715 3293 PMC4963347__F2 Schematic representation of de novo and salvage pathways for NAD+ biosynthesis 10135 23475 203447 PMC4963802__F1 Wnt signaling pathway 4041 4040 54894 59352 8549 55366 324 PMC4963810__F2 Comparison of the Drosophila and vertebrate non-canonical Wnt pathways applicable to this proposal 81029 54361 57216 4163 387 PMC4965740__F8 Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways 55502 388585 207 3280 2033 6929 3717 6774 5295 23493 4086 25942 6502 7528 429 1840 3932 2932 55294 4790 5296 182 83737 2647 8819 5664 2273 55759 4100 23013 8650 351 4851 4854 22938 54567 3714 3066 3516 4853 51176 28514 4088 10683 55534 5663 84441 1272 PMC4973429__F2 Involvement of AKR1B1 in pathophysiology 231 5228 5226 PMC4976849__F1 Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis 5981 100 1719 10257 8714 8836 2356 471 4363 1244 5243 2618 4522 4552 4397 4524 875 PMC4981961__F6 Phagocytosis and proteasome pathways 6402 9118 27040 7408 PMC4982242__F1 Non-activated canonical Wnt signaling pathway and the drug targeted components 4040 4041 8658 324 1499 PMC4983807__F4 Members of receptor tyrosine signaling pathways that are predicted as indispensable nodes and targeted by cancer mutations, OMIM disease, viruses, or FDA-approved drugs 25 3479 5595 5894 5598 3480 5925 3481 5979 998 5599 3630 6464 1445 5601 3643 4087 1857 1915 3667 4609 4088 10499 4914 3716 4089 1956 2048 6654 3725 3845 7010 2064 5058 2065 5604 7046 5159 6416 7048 2260 5170 5594 7409 2932 5879 1432 3265 5880 3717 3320 3932 4791 207 5914 5295 596 1387 7150 4193 1021 595 7157 PMC4985245__F1 IL-33 signaling pathway 90865 4615 51135 11213 3656 7189 PMC4985506__F7 The HGF/Met-FOXM1 positive feedback loop 3082 6774 2305 595 891 PMC4986885__F3 SRSF1's roles in transformation in breast cancer 4609 6426 6241 6240 274 2872 PMC4987202__F1 Axotomy activates the Wallerian degeneration pathway for the selective elimination and degeneration of severed axons 23098 23057 4803 PMC4987408__F3 Regulation of rhein on the crosstalk of MAPK signaling pathway 7038 3791 51701 PMC4990292__F1 Colorectal tumorigenesis in proximal/whole-colon and distal serrated polyposis 3845 673 3240 387569 4255 324 8315 PMC4991391__F4 N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications 4249 1956 1950 PMC4991449__F8 Adipocytes WNT5a mediated dedifferentiation: a possible target in pancreatic cancer microenvironment 3569 3570 4920 6774 7474 6425 PMC4991833__F4 Simplified model for the symbiotic signaling pathway in legumes 79902 55746 51199 207115 PMC4992436__F2 Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology 7187 7186 5971 10563 6387 PMC4993636__F2 Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network 154796 4336 10207 PMC5008583__F4 KEGG in Graphviz view of Jak–STAT signaling pathways on a canonical signaling pathway with gene methylation chip data 10252 161742 598 6654 2885 5770 4609 5777 1271 868 5290 3718 208 1154 896 10254 1387 6773 8651 10379 10401 5292 PMC5011664__F1 Canonical wingless/int-1signaling pathway 999 4040 4041 1499 324 1452 2932 8945 7088 PMC5012964__F3 Steroidogenic pathway 1583 1586 3283 3284 3294 3293 1589 1584 PMC5021946__F4 Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways 11343 55750 1606 63826 1491 875 191 189 1786 27232 64902 2731 PMC5024535__F6 Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression 1806 1807 51733 1890 1841 7298 978 3704 5423 1633 4922 79077 PMC5027135__F4 A new model of MC4R microcircuitry 4160 181 5443 PMC5031610__F2 Current knowledge on the cell type/context-dependent regulation of Wnt/Beta-catenin signaling by NFKB pathway 324 84445 847 51176 PMC5036249__F7 Proposed mechanistic scheme of CA4 suppressing the Wnt signalling pathway in colorectal cancer 762 9589 1499 7490 PMC5039366__F5 Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells 7431 6259 2932 324 1499 PMC5039409__F3 Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula 27343 7442 1956 57016 2932 5468 4129 3156 4513 43 1139 153 1636 5972 154 PMC5040721__F2 Possible adverse effects of obesity on osteoblasts 50964 4256 5741 2638 3569 11167 126669 3570 6010 2885 2932 6774 440514 2475 2308 468 860 PMC5040721__F3 Possible adverse effects of obesity on osteoclast 8717 729230 3569 7186 7189 7188 3570 6714 2885 2475 PMC5043614__F1 Molecular subclassification of triple-negative breast cancer (TNBC) based on gene expression profiling 672 7157 998 2885 6714 5728 2475 PMC5050510__F4 Repeatability of cortisol stress response in the European sea bass (Dicentrarchus labrax) and transcription differences between individuals with divergent responses 2271 2161 5340 718 2152 2160 717 2155 7450 2157 720 2159 2153 2147 5091 2 1431 1380 1361 928 735 PMC5056327__F1 Phosphatidylinositol 3 kinase/Akt pathway 930 3667 5728 572 7249 7248 5208 4193 331 PMC5059430__F9 EtOH-induced BK channel internalization via Wnt/Beta-catenin signaling 4040 4041 324 1499 PMC5059871__F2 Osteosarcoma cell proliferation is regulated by lncRNAs, including H19, MALAT1, ANCR, and PACER 5111 282 1017 387 1019 283120 PMC5061598__F2 Proposed model for how the activation of ECM receptor pathway in the adipose tissue is linked to obesity-associated insulin resistance 960 948 7494 472 7422 PMC5063512__F6 Schematic showing the mechanism of IGFBP-2-mediated regulation of Beta-catenin pathway in glioma cells involving A5B1 integrin, FAK and GSK3B 2932 1499 4313 79923 3485 PMC5064990__F3 KEGG pathway for insulin signaling 3630 3643 7249 6009 572 2475 2885 PMC5071376__F2 Diagrammatic representation of the integration of leptin and insulin signals in the regulation of energy homeostasis in the central nervous system 5443 4852 6774 PMC5077201__F6 Possible model of TIPE2 inhibition of activation of TAK1 signaling 7189 7186 23118 10454 PMC5078854__F1 Metabolic pathway of citrate and isocitrate on the citric acid cycle in the mitochondrial matrix and in the cytosol 50 48 3417 3418 PMC5082387__F2 TAM-dependent immunity 3586 324 8205 338376 387 6773 PMC5085216__F8 Prevention effect of rare ginsenosides against stress-hormone induced MTOC amplification 1442 10468 7428 672 5888 PMC5087334__F6 MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage 387 6010 7204 8915 10892 1540 PMC5088199__F1 Cellular pathways currently being targeted in the treatment of endometrial cancer (EC) and the potential actionable genes in EC identified via Next Generation Sequencing (NGS) 3845 5290 5518 8289 572 5728 6256 4193 55294 5426 56655 5427 5424 57804 10714 5425 PMC5088520__F2 Pathway-expression-networks produced for B cell CD19+ (top), T cell CD8+ (bottom left) and T cell CD4+ (bottom right) based on the transformation of the NOTCH Signaling Pathway done with Path2enet 930 4242 8650 920 1855 1857 2033 9253 151636 3955 1488 PMC5091819__F1 Fronto-striatal circuits originate in the frontal cortex and pass through the basal ganglia, which project via the thalamus back to frontal brain areas 5153 2638 2821 PMC5098220__F3 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks 5894 3559 3557 4615 9111 3552 1398 6850 2113 7850 4067 8648 3553 7429 5515 3718 2114 2908 8027 3716 29990 5914 3563 5777 6256 54472 140885 5781 7534 57161 1439 3554 8517 51135 1051 3654 9020 1147 4790 6885 5537 5970 4215 3717 10746 8202 5747 7852 4792 7189 2534 2033 958 7414 5590 5829 3575 9046 3566 5296 7525 5921 3667 5295 2242 8835 1759 3558 3561 7006 100124696 596 9021 7409 572 5879 8660 2885 3725 6774 1399 5594 51701 6461 867 3320 9846 6772 868 6464 3055 10018 7015 5293 7529 2475 6654 5335 5580 5294 6198 PMC5099257__F6 Multiple signal transduction pathways and transcriptional networks during cold acclimation in D 867 23379 22931 PMC5100880__F6 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer 1017 572 5728 4193 596 367 PMC5100880__F7 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer 1017 572 5728 4193 596 367 PMC5102790__F2 Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma 1378 4163 1950 1499 PMC5108608__F1 Diagram of possible GPC3-mediated signaling pathway in HCC progression.Abbreviations: GPC-3, glypican-3; HCC, hepatocellular carcinoma; P, Phosphorylation 2719 2821 4087 4088 1499 5728 5163 5879 4609 4318 572 4089 PMC5110454__F1 DRAStic RHOAdblock of Pyrin inflammasome activation 718 3845 387 4598 5586 5585 3586 3569 4210 3603 834 PMC5111231__F2 Hypothetical pathway regulating the response of skeletal slow twitch muscle to endurance training: myogenesis, fuel usage, and myosin fiber type change 3091 8720 4654 4208 4118 PMC5114008__F2 Adaptive Stress Responses During Tumor Metastasis and Dormancy 22926 83939 85451 468 PMC5116261__F1 PI3K signaling: a molecular pathway associated with acute hypophagic response during inflammatory challenges 3643 3953 3717 6774 5728 7248 7249 6009 2475 5443 PMC5116860__F3 Mechanism of action of metformin 5310 5311 5728 55872 2475 1977 PMC5120243__F5 Network model for CTNNB1 and related genes 2017 84433 1739 23379 6760 1500 8826 1501 4437 6597 999 5294 4851 387 324 1495 2494 2046 1969 1499 10499 3728 4089 4609 1387 5770 2735 3082 1956 6934 51176 5727 2064 7291 2638 6615 2932 595 6476 PMC5124618__F1 Changes in the VE response to inflammatory stimuli during sepsis 1003 7035 4353 3383 PMC5124975__F3 Galectin-3 and IL-33/ST2 axis interaction in diet-induced steatohepatitis 3958 6761 90865 PMC5132145__F4 Phagocytosis of apoptotic corpses 7204 324 10979 391 4534 998 29924 25 PMC5136497__F3 Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis 51311 51284 7099 51135 3654 7189 7187 23118 10454 3663 3659 3665 3552 4513 4615 PMC5142754__F2 Targeting Inflammation in Cancer Prevention and Therapy 727 718 7099 3661 PMC5144662__F6 T-cell receptor (TCR) signaling pathway 27040 7462 2885 1493 7535 9402 920 915 10298 3932 4773 5777 4772 5062 29851 940 867 9020 3265 3558 387 3565 3725 916 2353 3567 917 4791 2534 1437 3551 1019 PMC5145761__F1 Displays canonical IL-1 signaling pathway identified through Ingenuity Pathway Analysis (IPA) 4615 54472 7189 51295 23118 85451 3725 PMC514698__F1 Known Yeast Cell Cycle Interactions 1201 990 991 PMC5147901__F3 Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection 6376 1524 55915 25793 3240 7186 9314 1436 9612 3458 27086 3586 55686 PMC5152733__F1 Lymph node fibroblastic reticular cells in health and disease 4280 4055 10563 3383 7412 643 7852 6363 6366 8174 51266 4791 920 10630 4240 PMC5154770__F1 Naïve T cells are predominantly oxidative and constantly monitor their environment for immune insult 4609 2475 3600 PMC5159669__F7 Proposed models of two separable mTORC1 pathways 6009 7248 7249 7030 201163 PMC5166973__F7 Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer 4609 27250 1977 PMC5173117__F3 Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer 4953 6723 6303 6611 PMC5176079__F1 Stress kinases in the modulation of metabolism and energy balance 3667 29904 1386 2002 3727 PMC5176143__F3 Zrf1 controls the temporal expression of the genes related to cardiomyogenesis 9350 4838 652 10637 22943 8320 55897 6910 2626 93649 3670 9421 9464 89780 PMC5178148__F2 Hypothetical model depicting a potential role of SMAD3 activation in GCT development 7049 7046 2626 4088 2308 2309 2152 5728 668 57761 PMC5180601__F6 Condition-specific dependency network (CDN) for indisulam for drug-sensitive cell lines 2033 768 3725 112399 1385 405 7428 5034 3091 54583 444 7422 1906 2034 8453 3320 3939 PMC5181566__F3 Two sets of peripheral proteins (blue and red) with the same core proteins (green) are shown 4093 367 6774 4087 6667 5970 2033 4088 3725 672 5925 2099 1387 7157 PMC5183627__F1 TGR5 regulates different cell signaling pathways 2932 8989 387 6010 6774 83737 PMC5188458__F1 Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease 4397 875 4524 PMC5190013__F10 Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers 1499 4040 4041 324 4609 2932 595 999 4316 PMC5195921__F8 G protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis 4280 948 2690 3717 5465 1581 1593 9420 1582 26291 PMC5201094__F7 Hypothetic model illustrating the pivotal role of CD37 status for R-CHOP outcome in DLBCL and the important molecular mechanisms for R-CHOP resistance in CD37−DLBCL and CD37+ABC-DLBCL 951 4609 6774 613 7852 55364 27086 3662 695 29851 23308 11201 PMC5204264__F2 Proteome complexity and the forces that drive proteome imbalance 4609 11201 1999 4899 4094 PMC5210567__F4 KEGG pathway maps for (A) non-small cell lung cancer (hsa05223) and (B) EGFR tyrosine kinase inhibitor resistance (hsa01521) 2272 572 2064 1610 842 5914 1956 5728 3273 4763 581 2621 558 PMC5214989__F2 Mitonuclear gene groups associated with disease in GWAS are significantly enriched for protein–protein interactions 9201 1012 2066 2200 10018 1653 5366 8224 2272 1634 4170 348 5894 472 54205 6622 10019 64968 59 7015 596 1785 83857 80224 9415 70 335 217 2222 7494 3638 10452 1072 287 118881 25902 11075 8193 87 7037 1353 4155 4336 57128 140901 285521 54363 84273 3856 147495 80746 1373 6185 9790 8803 501 1743 25953 4482 127018 2768 3670 7422 23308 940 25813 549 388 35 5583 311 81894 6157 5869 3658 23305 274 3416 48 2879 6583 10109 5660 2581 1738 11315 1491 572 6150 51499 56945 27030 10221 PMC5215528__F1 ARE gene product interactome 7040 4609 595 3725 1017 2353 7157 898 1869 1977 4843 1950 5744 3603 3586 331 6347 2920 3553 3562 1437 5155 330 2254 6348 1435 596 4312 4318 2247 3569 7422 2921 7124 3576 4313 5328 5743 7412 6387 4322 PMC5216695__F7 Beta-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response 3481 7422 3480 PMC5226641__F1 Dysregulation of MicroRNA Biogenesis Machinery in Cancer 29102 54487 57510 5901 PMC5228377__F6 The signaling pathways involved in wogonin-induced autophagy 2475 8408 1540 PMC5233421__F6 Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability 5270 406971 574445 3383 5175 7412 PMC5233600__F1 NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection 4615 8011 51135 114548 9447 3603 PMC5233753__F1 Schematized general estrogen signaling pathway 22943 2475 1499 PMC5239436__F1 Autophagy complexes cell death by necroptosis 581 8717 7186 8737 8772 197259 11035 PMC5239781__F1 Complement activation 5648 718 717 721 4179 1604 2271 727 729 966 PMC5241319__F3 Systemic complement in metabolism 7038 718 727 721 716 27202 PMC5241340__F8 Hypothesis of miR-567 modulation in healthy and BC cells 4088 693152 4089 4087 PMC5241776__F2 Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics 7349 6424 1994 7341 1393 3977 3091 54361 1404 1856 112714 10926 8266 1395 387 2908 9181 114907 407 7419 79666 4624 64094 2885 3921 7060 4147 5829 961 8815 26277 27232 26088 3265 896 3845 9370 5580 253260 595 2475 51422 5583 4609 5565 5970 3624 4340 2022 7044 51176 7124 3727 26136 2353 PMC5244366__F1 Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway 1950 1956 995 673 PMC5244594__F12 Working model of how the glucose dual-affinity transport system functions in glucose transport, signaling, and CCR 108348016 28964 9541 PMC5245710__F6 Human SRMAtlas: A resource of targeted assays to quantify the complete human proteome 5411 6470 5634 54443 3925 9493 4288 5557 64151 5591 5111 6723 3151 5983 10615 5985 4176 4171 4173 4001 6240 51203 4174 29128 7153 7112 6241 84823 220988 3843 PMC5247290__F3 TGF-b/BMP signaling pathway in osteoblast differentiation 4090 4086 4087 4088 4089 860 PMC5249061__F6 A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma 406947 10247 3725 406948 4609 4280 64750 53366 2597 PMC5250648__F2 Ca2+ induces autophagy 120892 2475 7942 55283 PMC5258846__F1 Microtubule motors drive Hedgehog signaling in primary cilia 51684 2736 2737 374654 6608 PMC5259950__F6 Canonical Rho signaling pathways were identified in a phosphoproteomics screen of HIV-1 signaling via CD4 and CCR5 3929 2335 1950 2149 929 2885 55970 89846 2245 7204 2316 1398 998 28964 387 1793 5829 324 10458 7414 2934 PMC5260886__F8 The serglycin–CD44 signaling pathway in NPC 960 1499 4609 595 PMC5260980__F2 Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer 1950 6935 3728 9839 2335 7431 3371 PMC5267499__F1 Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins 572 2475 5447 4937 7374 10011 26136 PMC5270476__F1 Reelin's role in stabilizing the cytoskeleton 7436 1600 1398 998 2475 3984 2932 PMC5272809__F2 New View into the Regulation of Purine Metabolism – The Purinosome 2618 5471 10606 158 471 PMC5285405__F3 Viruses exploit host proteasome pathway for immune evasion 4361 10111 1616 546 6672 5371 3428 3661 5970 4118 4615 3665 PMC5285449__F1 Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis 4771 154796 6010 23513 4485 9113 26524 182 4853 PMC5288579__F10 Group I Paks as components of the Ncad/Cdo signaling pathway 1000 1499 998 5062 5058 PMC5290198__F7 BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling 3569 23476 4851 PMC5292790__F1 Immune response in the polar clinical forms of leprosy 920 30835 7421 9332 11027 3949 4035 PMC5293166__F4 Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy 5728 60468 2308 50943 6402 717 1236 3458 PMC5293764__F1 Carbohydrate metabolism in I 7086 2597 5230 28976 3419 2271 PMC5295437__F8 Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway 7248 7249 6009 PMC5295669__F2 Modes of DNA synthesis 5111 5426 5893 5888 51426 80119 PMC5295849__F9 Proposed model of CXCL12 signaling to mTORC1 in BMM 6387 7852 5266 5879 5335 7249 7248 PMC5296610__F4 Most significantly relevant pathways and highly linked molecules relevant to the merged bionetwork 1356 83715 355 6957 1269 10763 4837 PMC5297047__F6 The G-protein, cAMP/PKA signaling alterations found in the ZMEL-R1 cells 2868 156 5906 6714 6774 PMC5302553__F2 Efferocytosis in Atherosclerosis 10461 4035 348 811 961 19 2520 3586 PMC5302996__F1 LncRNAs in pancreatic cancer 60674 1019 1021 595 83540 100124700 9518 100316868 6790 11091 378938 6657 283120 8091 PMC5306280__F1 Activation of the canonical NFKB pathway 7124 940 7189 7186 3932 7535 6850 5163 5335 PMC5310224__F3 The unfolded protein response in immunity and inflammation 7099 7189 468 7124 2932 3553 PMC5312359__F7 MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells 999 4763 3236 389 PMC5312370__F6 RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy 2475 6774 5888 142 PMC5316546__F1 Our strategy to increase seed oil accumulation by overexpressing the plastidial pyruvate transporter BASS2 under the control of a seed-specific promoter in developing A 2875 95 355 5091 10350 PMC5325806__F2 Intersections of Post-Transcriptional Gene Regulatory Mechanisms with Intermediary Metabolism 23411 2308 5631 3190 2539 1153 6428 PMC5328835__F1 Role and mechanism of action of Sclerostin in bone 5741 7124 50964 4040 4041 4038 1499 PMC5328987__F1 Type III IFN signaling pathway 3588 7297 8651 6773 3661 11274 4599 282616 282617 101180976 PMC5329931__F2 Effects of TAMs on tumor progression 6362 6279 8205 PMC5331612__F1 ChREBP regulates fructolytic gene expression 3795 26007 5313 2194 PMC5332432__F1 Activation and control mechanisms of the human complement system 2271 718 727 966 PMC5332883__F1 For PD-L1 modulation in HNSCC 1956 5728 5163 5164 6772 5266 6774 PMC5336479__F5 Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines using TMT 10-plex Isobaric Labeling 2064 1017 9367 3667 2065 2539 8660 6464 8503 5580 5127 2066 2885 5163 207 998 2475 2002 PMC5337497__F3 Schematic presentation of the tricarboxylic acid cycle (TCA) pathway and amino acid biosynthesis, as affected by the chlorotic mutation 1737 1738 11113 1431 47 1743 162417 435 PMC5339410__F6 JAK-STAT and chemokine signaling pathwaysA 8027 9021 3455 3716 3460 3717 3561 3718 6774 598 6777 10379 207 6655 2885 6347 6714 4067 5595 113 5566 PMC5339794__F3 Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis 9194 5981 2099 3119 3123 26191 7040 7099 4283 3627 4363 1244 8714 10257 9429 55867 113235 2356 8836 270 100 471 595 7298 1719 4552 4397 4524 875 PMC5340150__F1 Autophagy in infection, inflammation, and immunity 9140 23586 64127 55054 2475 7189 114548 9447 3553 7939 3146 PMC5340842__F1 P. infestans infection cycle and the many roles effectors play in modulating plant cellular processes 7018 578 10746 5605 5606 5604 4214 PMC5342747__F5 Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells 3479 3480 1956 1950 8205 PMC5342869__F1 Regulation of the Hippo-YAP pathway by extracellular biophysical cues 2548 6010 4485 9113 26524 81539 8140 PMC5343938__F3 Role of the RIG-1-like Receptors (RLRs) signaling pathway in antitumor immunity 57506 29110 836 3661 PMC5344271__F3 Upon SV40 infection of mesothelial cells, Tag (Large T) and tag (small t) antigens are expressed 3479 3082 3480 4851 1956 PMC5344902__F1 Pattern recognition receptor signaling that leads to the induction of type I interferons (IFNs) 7099 51284 51311 54106 7098 4615 57506 7189 8717 29110 3654 3550 3661 115004 3665 PMC5344902__F2 Type I interferon (IFN) signaling 3454 3455 7297 3716 6772 10379 6773 207 PMC5345976__F10 Scheme summarizing the protective effects of Xn on LPS-induced acute lung injury via activation of the AMPK/GSK3Beta-Nrf2 axis 3553 2932 10628 114548 PMC5346319__F4 p53 dependent and independent tumor suppressive functions of ARF 4193 1487 545 1488 472 7486 1869 2305 604 PMC5346332__F3 Role of Aim2 protein in non lupus-prone and lupus-prone strains of mice in the regulation of type I IFNs production 9447 4280 3454 3455 3661 29110 10379 3665 PMC5346727__F4 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method 994 5871 7132 5155 658 23118 9261 3727 5906 7186 3265 3315 5530 4773 392255 4609 1616 8517 4091 7018 1649 406958 4790 3725 1874 1540 2626 133 9734 826 4751 53354 PMC5346727__F5 Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method 658 406991 3553 5155 7132 3563 3575 3454 2768 3265 1616 2353 10746 994 4609 7186 392255 8517 4091 4791 7018 6774 1874 4790 3725 826 4616 1540 2626 4751 53354 PMC5348798__F3 Cdk5 takes part in DDR through STAT3 pathway 1020 6774 595 146956 4609 PMC5350184__F3 Genes involved in skeletal muscle TLR‐ and insulin receptor signaling related to changes in plasma concentration of fetuin‐A and FFAs 1385 5170 257397 5290 528 7248 5594 2887 5600 1978 6654 6197 5565 4205 5563 30849 8411 5296 5516 8767 51311 8817 7096 353376 208 51284 4893 9641 51135 1520 2264 PMC5350518__F8 Proposed molecular model of VCAM-1 regulation in ccRCC-VHL–expressing cells 5970 5966 5971 7428 7412 7124 PMC5351557__F2 Yeast mitogen-activated protein kinase signaling pathway, illustrating the signaling paths in responses to different signals 4117 6761 84188 2739 PMC5354690__F1 FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification 6010 2475 4851 4208 PMC5354695__F1 Long noncoding RNAs in head and neck cancer 101928337 100996569 100886964 283131 1021 5820 7253 2146 100124700 5728 999 7422 101927703 2296 283120 55384 1789 PMC5354803__F5 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis 3553 4513 6615 9021 6774 5465 619501 847 5728 864 5894 4968 PMC5354977__F1 Interplay between immune checkpoint proteins and cellular metabolism 941 1493 2475 3091 5163 3939 PMC5356785__F1 ΔNp63A and microRNAs: leveraging the epithelial-mesenchymal transition 2475 5163 2932 4087 4089 1499 5728 6935 PMC5356913__F2 Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation 695 6850 6010 PMC5357501__F4 The significance of SIRT1 in Alzheimer’s disease 23411 5915 23621 102 351 PMC5359955__F2 Title: In PI3K-Akt-mTOR signaling pathway, PI3K inhibits autophagy via activation of Akt 7248 6009 7249 2475 9776 PMC5362152__F7 Schematic representation of the proposed model 1956 6935 999 PMC5362547__F1 Hippo signaling pathway provides novel anti-cancer drug targets 60485 4485 55233 92597 9113 26524 558 PMC5366820__F2 PDK1 contributes to polarization of signaling downstream to PI3K during cell migration 5163 5335 387 PMC5368685__F2 Pro-inflammatory response through TLR: various antigenic molecules are recognized differentially by TLRs, which produce pro-inflammatory responses 2821 7097 10333 7096 4615 51284 7099 54106 PMC5369137__F1 Metabolic pathway of clopidogrel and its targeted receptor 1066 1544 1557 1555 1559 1576 PMC5369176__F1 Physiological functions of PD-related Rabs 10890 11021 10981 5872 PMC5369246__F1 Signaling pathways of ATM and ATRThe DNA damage response is activated by ATM, ATR, and DNA-PKcs 472 545 6741 5810 84126 10763 2177 1869 1870 1871 993 5888 PMC5369916__F4 Summary of detected genes associated with the MTX toxicity in RA patients in previous studies 9194 4363 1244 5981 113235 5243 9429 3704 2356 8836 270 100 471 595 1719 7298 4552 4524 4397 875 PMC5371797__F2a Non-Canonical Roles of Dengue Virus Non-Structural Proteins 1431 57506 29110 3661 PMC5376075__F3 TRL2 pathway is activated by Tollip and results in IRAK suppression 3654 54472 51135 7189 5970 114609 4615 PMC5377334__F3 Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133 2669 7018 4609 7020 1869 6256 6667 367 PMC5381403__F1 Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients 1956 3845 545 472 3932 23683 2290 8522 4286 8924 5983 2033 5001 6597 23026 84687 9646 56943 2145 3643 3624 150572 64324 7270 10765 PMC5384577__F2 Possible roles of Mgs1 and WRNIP1 in DNA transaction 5888 5893 118027463 353497 56852 5111 84893 4361 56897 675 472 23300 PMC5387055__F3 Upon antigen encounter T cells differentiate into effector cells 940 5335 207 2475 4609 1493 3091 PMC5390594__F1 AMPK and JNK signaling pathways are shown above 3553 23411 9448 3603 PMC5390594__F2 Notch signaling pathways are shown mainly above 3656 1977 9021 3394 PMC5391240__F5 MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2 4087 4088 596 2932 10023 324 1499 PMC5393155__F10 Insulin receptor signaling pathways 3667 5728 2475 2000 PMC5393392__F3 Protein interactions during the flavivirus life cycle elucidated by MS-based proteomics 4199 348 4928 9026 5912 153443 3265 10113 8729 7251 22931 PMC5394057__F1 Cellular mechanisms of radioresistance: (I) the cell cycle checkpoint signaling pathway is a critical progress that allowing times for cells to response to repair DNA damage 472 545 1000 999 960 9429 PMC5396623__F4 SPARC overexpression alters microRNA expression profiles involved in tumor progression 7124 27177 27179 4325 6774 6283 4784 26525 56300 27178 1075 PMC5397262__F2 Misregulated expression of members of the ubiquitin cascade contributes to the aberrant signaling of various pathways in cancer 7124 9958 7375 8717 64750 27338 7428 7335 4092 5252 81858 55072 10616 4089 4087 4088 11059 7345 10273 PMC5397865__F8 Salt suppresses IFNG inducible chemokines through the IFNGamma-JAK1-STAT1 signaling pathway in proximal tubular cells 2833 3458 3627 2919 4283 3459 3460 3717 3716 6772 PMC5402749__F1 Necroptosis and Cancer 7124 7186 1540 8737 11035 8772 197259 23118 257397 PMC5406580__F2 Hypothalamic circuits regulating thermogenesis of BAT and browning of WAT 4852 4353 4160 3953 23237 181 5443 PMC5406714__F1 Targeted Inhibition of Hepatocyte Growth Factor (HGF)/c-Met Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) 3082 2549 2885 6774 PMC5410568__F1 The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases 22926 581 7186 83939 468 PMC5411014__F3 Pathophysiology and management of CVD 3383 7412 717 105031671 718 727 729 PMC5412355__F3 The UPR downstream signaling pathway 22926 1998 7494 PMC5414786__F7 Components of insulin signaling pathway and the up-regulated genes with H3K27ac- or H3K4me3-increased regions by decidualization 867 2308 3643 355 2475 2885 126669 PMC5419442__F9 Possible Signaling Pathway that Mediates FSH-Induced Meiotic Resumption of Mouse OocytesAfter binding with its membrane-integrated receptor in cumulus cells, FSH uses PKAII as a downstream mediator after a transient increase of cAMP 2492 1956 847 367 PMC5423858__F1 MicroRNA function in Drosophila memory formation 4204 27343 11201 5901 PMC5427056__F1 Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy 3667 5163 5728 4763 64798 6446 7248 3240 6009 8408 1975 1977 2308 PMC5427079__F6 Reactome pathways displayed in Figure were converted into a functional interaction network using FI network view 336 2239 440387 6947 4547 221914 6383 3990 91289 319 2 1071 11330 81693 4137 PMC5428476__F10 Model depicting the involvement of autophagy-lysosomal system in apigenin-induced degradation of Beta-catenin during Wnt signaling 4040 4041 2932 2475 PMC5429325__F1 Action of branch‐chained amino acids (BCAAs) 2475 23411 5443 PMC5429979__F3 Serine/glycine metabolism in proliferating cells 26227 29968 5723 1719 4522 6470 10797 6472 PMC5431827__F8 Proposed mechanism by which HBV hijacks IFN/JAK/STAT pathway via activating SOCS2 to facilitate immune evasion and viral infection 7297 3716 7084 8835 10379 6773 6772 3455 3454 PMC5432127__F1a Maternal obesity on placental function and fetal development 5465 2475 51094 79602 3667 PMC5436210__F3 Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma 1149 5140 4303 3416 6319 3630 6788 2099 6720 367 27161 4000 8742 23405 4208 6442 PMC5436704__F3 Cell–cell communication and cyclic AMP coordinates oocyte meiotic maturation in worms and mammals 7409 1600 5139 PMC5437570__F3 Interaction of antagonists with Wnt5A/Ryk signalling in vascular endothelial cells 1003 1499 1072 PMC5438149__F7 Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro 6010 5879 8521 PMC5442340__F4 KEGG pathway for Hippo signaling pathway 154796 9113 26524 166824 374 174 4609 1499 6655 192 PMC5442340__F5 KEGG pathway for PI3K-Akt signaling pathway 2475 7249 2885 5879 613 4609 951 5934 5728 572 5266 150365 6256 PMC5442421__F1 Simplified scheme of ‘the metabolic map of cancer cell' 2821 2597 5106 PMC5445933__F3 Main pathways altered in GEMMs of cutaneous melanoma 3082 2911 5979 5728 2475 1017 4193 PMC5448611__F9 PPI network of new predicted LUAD-related genes 57188 3579 6693 1104 10529 88 1478 7516 7298 58494 659 5241 9510 6345 7048 5583 948 122953 116984 7058 2313 2247 57381 7078 90627 2202 3727 64759 83478 91687 9314 166336 1960 8676 8322 1356 84617 4288 6925 6586 9353 9060 PMC5449086__F8 Schematic model of the regulatory role of ADAR1 in liver homeostasis 57506 3661 6347 6352 3569 PMC5449757__F1 Schematic depiction of uPAR/suPARAvB3 integrin signaling at the glomerular filtration level in health and diabetic disease 3479 7448 2821 27293 PMC5451151__F1 Anoikis signaling pathway in cancer cells 355 6714 7088 PMC5452924__F1 Interaction of the E-cadherin-catenin complex 6714 999 324 PMC5452924__F2 Operating mode of the E-cadherin-catenin complex in tumor metastasis 1950 3082 7471 1956 2932 8826 324 595 1499 PMC5453167__F2 Protein-protein interaction network of the DEGs 5710 84539 10919 2113 3725 5781 64800 27136 PMC5454641__F1 mTOR Signaling Pathway 7249 7248 6009 PMC545795__F3 Largest connected subgraph resulting from combined query on four pathways involved in carbohydrate metabolism: glycolysis/gluconeogenesis (red); pyruvate metabolism (yellow); TCA cycle (green); and the glyoxylate cycle (pink) 5230 2026 65057 2571 11113 55276 8544 PMC5458280__F3 Carboplatin-induced hematotoxicity among patients with non-small cell lung cancer: Analysis on clinical adverse events and drug-gene interactions 920 914 952 960 8178 924 928 100133941 933 930 947 951 3562 7124 6717 945 929 7173 2056 966 2057 948 367 PMC5458543__F3 Fucose metabolism pathways and variation in types of fucosylated glycans 1950 2523 2530 2526 2524 2528 2527 84750 2529 10690 170384 2525 55343 23509 23275 PMC5465008__F2 Crosstalk between leptin signaling, cancer stem cells, histone deacetylases and microRNA 3953 406983 3952 406991 9759 406985 51564 100133941 8841 4072 79885 10013 PMC5466513__F1 Autophagy in UV damage response 10533 64422 83734 83667 9140 9474 7249 7248 7405 6009 8408 5728 PMC5467784__F7 Genes associated to tumorigenesis and/or cancer progression found differentially methylated in HA22T/VGH sorafenib treated cells 4316 4314 1437 1441 389 5879 2268 3958 57761 330 9447 3716 4087 6774 1026 26257 2309 2034 6777 896 4781 2353 11040 1386 9020 2475 8517 57580 5590 10892 7249 51347 5287 PMC5468653__F3 Prolific nicotine production in the genus Nicotiana evolved from stepwise duplications of two primary metabolic pathways 4953 1610 4353 PMC5470738__F1 Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List 4018 348 2056 4035 3949 55848 8086 PMC5470994__F3 DE genes are significantly overrepresented in the Toll-like receptor signaling pathway 3991 7124 100187907 54472 1147 23118 6955 2353 1513 4478 30835 2534 1796 4179 3596 3565 868 915 207 5290 940 3558 6774 3716 29110 57506 3661 64135 3439 3456 3665 4790 3569 7097 3592 7054 10399 4938 6772 10379 103 4599 3458 595 8667 7157 7161 25898 356 355 27113 PMC5471631__F8 RIPK1 and RIPK3 kinases engage the IFN-I pathway downstream of the adapter protein TRIF 7099 8737 11035 29110 3661 197259 PMC5473974__F2 The glucocorticoid receptor and nitric oxide signaling pathways 183 6908 154 367 PMC5474285__F1 Workflow: network analysis, relevant organ location network analysis, gene ontology, and pathway analysis were performed on active compounds identified in Pulsatillae Radix (PR) by screening and target fishing 4352 4351 4018 324 572 581 PMC5476461__F4 Regulation of antioxidant production by HIF-1 23657 26227 29968 5723 6472 2730 10797 25902 PMC5479302__F8 Proposed signaling pathway activated by CTS in CCA cells.Notes: The potential mechanism of apoptosis induced by CTS in HCCC-9810 and RBE cells 3717 6774 581 PMC5479992__F1 Iron homeostasis 2242 148738 3077 7036 57817 PMC5482322__F1 The Plasticity of Cancer Cell Invasion 387 8205 275 PMC5482757__F1 Emerging Role of MicroRNAs in mTOR Signaling 5728 5163 7249 7248 253260 2475 6009 PMC5482757__F3 Emerging Role of MicroRNAs in mTOR Signaling 5728 627 27250 54541 7248 7249 6009 51719 PMC5482757__F4 Emerging Role of MicroRNAs in mTOR Signaling 5728 7248 7249 6009 4193 29102 PMC5484669__F3 Signaling pathways that are key regulators of pluripotency in mESCs 3976 6926 6657 79923 PMC5485329__F3 AMPK and mTOR pathway by Sestrins 50507 7249 7248 2475 8408 PMC5486002__F5 Examples of two pathways of histone modification by polycomb complexes leading to suppression of selected TSG 1499 648 9055 5928 545 472 1786 1789 1869 22943 6425 27123 27122 1019 PMC5486101__F1 Schematic overview of the autophagic pathway and potential drug target points of the pathway 60673 9776 8408 10533 64422 9474 9140 55054 83734 PMC5486142__F2 Adiponectin signal transduction implicating a cross talk with the insulin signaling pathway: Insulin and adiponectin interact with their respective receptors, which trigger a cascade of signaling events 51094 79602 26060 5163 5728 PMC5487850__F1 Biogenesis of microRNA (miRNA), extracellular vesicles (EV) and uptake mechanisms 29102 27161 4869 8829 PMC5489658__F8 Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways 3460 3717 3716 7297 57506 6772 6773 29110 3661 3459 163702 3454 PMC549180__F2 ErbB signaling pathway 126669 2885 5728 572 2475 595 PMC5496032__F7 Mechanisms on EET-mediated signaling in response to cardiac hypertrophy and fibrosis 387 207 3603 7076 PMC5498918__F1 Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity 7350 3280 26508 23462 63976 PMC5500325__F7 Nutritional and reproductive signaling revealed by comparative gene expression analysis in Chrysopa pallens (Rambur) at different nutritional statuses 759 355 3630 7249 6009 572 2475 2885 PMC5501176__F4 Roles of Autophagy signaling pathway in cancer in type 2 diabetes 6794 5170 7249 7248 6009 253260 PMC5501852__F6 Interaction network of cancer cells and their microenvironment associated with the EMT process 1634 7058 7104 3624 655 6469 4052 3481 857 858 7124 2335 168667 5727 5154 7040 7039 1950 4254 3082 64750 4089 6608 6422 1956 4092 4091 4087 4088 2064 3815 2521 394 2932 7099 6714 3956 1499 387 1398 633 862 6774 5797 998 3845 5792 2475 50855 7454 5268 6615 92359 4312 7291 3725 999 PMC5504167__F2 Corticotropin-releasing hormone (CRH) controls the placental “surveillance and response” system so that the fetus can detect threats to survival and adjust its developmental trajectory 1392 9575 2908 PMC5504240__F1 Circadian metabolites have pleiotropic mechanisms by which to maintain cellular rhythmicity 9575 406 23411 51548 23410 4862 7434 11245 2475 8864 4200 PMC5504484__F4 Signaling pathways assigned to the Ingenuity Pathway Analysis (IPA) category “molecular mechanisms of cancer” that have been linked to ovarian cancer and targeted by epigallocatechin‐3‐gallate (EGCG) 1610 1398 2885 3667 673 572 637 3725 4609 581 4149 595 51176 5933 324 51684 27148 1616 23385 6608 PMC550674__F2 Apoptosis mediated by death receptors requires the FADD adaptor molecule 8772 7124 8717 7186 PMC5507964__F1 TLR7/TLR9 and B cell receptor (BCR) ligands incite B cell signaling cascades 613 695 6850 54106 51284 29760 4067 55024 640 638 4615 81704 3661 3665 3663 51135 3654 5336 7189 81622 6774 PMC5513689__F1 Alcohol’s effects on the hypothalamic–pituitary–adrenal (HPA) axis and the stress response 551 5443 3606 7124 PMC5514949__F7 Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway 4089 4087 4088 PMC5515036__F1 Biosynthetic pathway of cysteinyl leukotrienes (cysLTs) and cross regulation of their receptors 4049 4050 2840 PMC5516854__F3 Visualizations of Wnt pathway reconstructions 7471 7976 8323 7855 8324 2535 4920 8321 4041 6259 11211 4040 8325 2775 1000 2776 5330 23236 5595 1855 1857 1856 5594 5331 5332 5290 7311 1080 1956 5578 6885 5295 2932 8312 6233 6714 1454 2316 1460 4088 4087 1457 4851 4092 4089 4086 4773 6925 1499 5076 6929 1601 51176 324 PMC5520917__F8 OA-induced growth inhibition of colon cancer via reprogramming fatty acid metabolism under hypoxia 2194 3091 1499 324 PMC5521727__F1 Hsp90 and Physiological Stress Are Linked to Autonomous Transposon Mobility and Heritable Genetic Change in Nematodes 26136 353497 5465 PMC5522095__F8 Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer’s disease 1081 7099 114548 PMC5522315__F3 Epithelial-to-mesenchymal transition in the development of endometriosis 6657 324 999 1499 4089 4087 4088 2932 PMC5523822__F2 Altered B cell signalling in autoimmunity 4280 613 958 26191 7454 PMC5527460__F1 KRAS‐dependent genetic network analysis 672 2000 472 8562 23531 81671 1725 7167 3845 1603 11331 7170 10409 7316 51160 55250 6217 646 10199 26043 56852 5888 4664 4999 2237 85407 PMC5527674__F1 “Pushmi-Pullyu” of DNA REPAIR: Clinical Synthetic Lethality 142 10038 83666 9656 672 7158 545 11073 472 5888 7465 1111 11200 PMC5527800__F3 Ingenuity pathway analysis 183 4323 7076 7040 847 4313 1499 7070 176 6868 1909 4320 9510 2353 53947 952 3265 4837 51083 1511 958 1965 3952 960 3624 10365 1605 3726 3481 2208 3082 3727 3486 3934 3667 8431 4609 4314 5008 3383 5354 4017 5595 5594 6402 4311 6670 7045 5327 4092 633 5328 7038 6768 5329 9644 5747 PMC5527962__F5 Leukocyte transendothelial migration pathway is affected by RCT 387 5880 7006 100124696 3683 3676 7852 7412 7070 7408 3684 83700 3689 58494 4267 PMC5528384__F7 Cyclophosphamide (CTX)‐mediated immunomodulation on the basis of genes up‐regulated by treatment 6714 6850 64170 8915 2920 PMC5531453__F5 A, Multifactorial etiology of adhesion formation 5340 7018 3091 PMC5531462__F4 Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer 2122 8605 2247 2885 2268 2254 5567 PMC5531511__F4 Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort 10207 174 3689 324 PMC5534384__F2 The diversity and plasticity of adult hepatic progenitor cells and their niche 1499 648 1950 3082 7039 7124 4049 4050 PMC5535714__F3 Redox regulation of Wnt/Beta-catenin signaling pathway and lipid peroxidation 27035 5879 2932 324 1499 595 PMC5536086__F1 Proposed model for UCP2-SIRT3 (uncoupling protein 2-sirtuin 3) signaling pathway on cerebral ischemia–reperfusion injury 7351 23410 6098 PMC5536362__F8 G protein-coupled receptor kinase 2 promotes cardiac hypertrophy 156 2932 3251 PMC5536816__F3 Benefits of physical exercise (PE) act through or require a healthy, functional endothelium (beige cells) 627 4513 4035 1499 6647 23410 6649 3383 7412 PMC5537006__F1 Top Ingenuity Pathway Analysis networks associated with genes whose expression is altered by high levels of miRNA expression associated with both TP53 and CpG island methylator phenotypehigh and/or microsatellite instability 25999 140803 63916 9340 197407 51734 55759 11037 57732 197370 55224 83877 55531 121512 23567 286053 2908 3081 5533 8439 92140 81706 143 80213 10208 55145 10560 9100 537 196403 22984 84707 23604 1306 10847 84916 51522 197259 7732 23413 1039 2730 154810 64359 9522 54828 10043 132 2054 10054 81570 9853 6820 29028 608 7335 22928 54552 4609 5831 84674 2717 8836 147906 55655 8741 220107 5937 79077 282679 11135 51070 7123 51230 30811 10301 6224 59342 79465 PMC5538252__F4 Sepsis and septic shock 1003 4353 3383 PMC5539153__F8 Representative model of some signaling pathways in a human breast cancer cell (MDA-MB-231) that can be modulated by GCdcPLI 4513 4193 2475 572 581 596 598 PMC5539204__F6 Complexity of the miRNA-mRNA interactome network in rat soleus muscles with cardiac cachexia 4325 3688 4060 169044 64094 83660 PMC5539260__F5 Host/pathogen cross-talk mechanism through core pathways at the early stage of C 409 7184 2335 51435 5728 7102 10987 387 6794 120892 5879 7528 6188 6850 2885 2113 51450 284424 114614 642345 5058 367 PMC554120__F8 The inhibition of Myt1 in the meiotic and mitotic cell cycles in Xenopus 995 4342 4661 PMC5545849__F1 TGFB signaling pathway 7046 387 998 PMC5547388__F5 MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells 1950 367 685 3725 126669 2885 2475 572 145957 PMC5552241__F6 Proposed model of the Src/IGF-IR signaling axis present in both prostate cancer Exo and cells 3479 2870 6714 PMC5553593__F7 Interaction network of lysine-succinylated proteins in D 6395 6418 717 PMC5554756__F2 Negative regulators of the RIG-I-like receptor signaling pathway 339231 221079 64127 6397 9958 10206 286827 7706 54941 9960 9099 57506 79845 29761 PMC5558474__F3 Impact of glucocorticoid on neurogenesis 6446 6608 22943 1499 PMC555938__F6 The metabolic shift pathway of yeast Saccharomyces cerevisiae according to the dynamic regulatory modeling in Table 2 3297 2026 7167 389434 2203 PMC555938__F8 The pathway of metabolic shift regulatory system of yeast Saccharomyces cerevisiae in Fig 3297 2026 7167 389434 2203 55276 PMC5562928__F2 Amino acid degradation in I 9054 10157 125061 2806 100682260 3034 3081 6821 2954 8942 144193 2184 275 2731 11153 1738 2653 23464 2744 157739 5625 10993 4942 PMC5564037__F4 Capturing Human Naïve Pluripotency in the Embryo and in the Dish 6774 3976 4041 3977 999 1499 79923 324 2932 6926 6929 389058 29842 6657 10365 9314 3720 29947 359787 1788 1786 29128 80312 54790 PMC5564072__F5 T cell receptor (TCR) signaling pathway in melanoma (modified from the BioCarta database) 7054 3932 2534 7535 27040 2885 5894 2002 PMC5567910__F8 A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development 6469 652 2294 6608 PMC5567913__F9 Graphical summary of the results 7939 50507 4087 10716 4088 4089 PMC5569249__F1 miRNA pathways in myeloid differentiation and myeloid-derived malignancies 7173 5728 2475 7832 PMC5569945__F3 Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia 3667 5163 5728 7249 51256 7248 6009 PMC5572180__F3 Alterations to the phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway and outcome prediction in ovarian clear cell carcinoma (OCCC) 5295 5296 5290 5728 207 208 PMC5572370__F7 Pathways of activation of naïve CD4+CD25+ T regulatory cell (Treg) (tTreg) 3568 50943 324 920 PMC5572616__F1 Effect of the Hh signaling pathway on the regulation of proliferation and differentiation of SSCs in mammals 4149 51684 50846 2668 PMC5572632__F1 NFKB signalling pathway is involved in the diabetic atherosclerosis 3667 57761 5091 PMC5572672__F2 Inherited and Acquired Disorders of Magnesium Homeostasis 10686 149461 23562 846 PMC5574206__F1 BMP signalling utilises canonical Smad dependant pathways and non-canonical Smad-independent pathways 25805 331 4734 57154 26994 PMC5575761__F2 Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway 920 5728 2475 2885 10750 27040 10538 PMC5577206__F2 Vascular endothelial growth factor-B in metabolic homoeostasis: current evidence 355 8829 7422 7423 PMC5578105__F1 Ubiquitin signaling in both sub-pathways of nucleotide excision repair (NER), global genomic (GG-) and Transcription coupled NER (TC-NER), and double-strand break (DSB) repair 472 9025 9656 165918 6045 9978 8450 1643 1642 8451 7508 7874 57654 4734 PMC5579609__F3 PC-DHA levels depend on nutrition, liver and brain synthesis by PEMT and transport of LPC-DHA across the blood-brain barrier catalyzed by MFSD2A 355 10400 4548 635 875 84879 PMC5580487__F2 Pro-apoptotic role of HBV 355 8772 581 317 PMC5580489__F3 Host DNA damage response pathways 3014 4361 10111 11073 545 472 84126 672 2177 2175 1869 675 PMC5581331__F2 P53 and pRB pathways during senescence 595 4193 1021 1019 1017 PMC5582909__F2 RAS pathway status in human DKD, based on urine concentration and enzymatic activity of RAS components 1511 59272 5476 1636 PMC5583567__F3 Chronic Cigarette Smoke Mediated Global Changes in Lung Mucoepidermoid Cells: A Phosphoproteomic Analysis 6464 3265 2475 64798 9776 PMC5584184__F3 Postendocytic sorting of receptors along the endolysosomal pathway 5266 11021 8411 26060 PMC5584588__F7 Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3’-end processing factors is a conserved DNA damage response in eukaryotes 7317 8452 9978 PMC5585386__F6 Schematic representation of a B 5091 95 4018 8694 84649 PMC5594516__F9 Schematic representation of the proposed mechanism of circLARP4 in GC cells 2638 113251 27161 9113 PMC5597247__F1 Transcriptional regulation of glycolytic and mitochondrial metabolism 226 4211 3091 4609 2023 3939 7351 4286 6774 PMC5601165__F2 Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions 5156 3815 6714 4342 6774 2475 4609 PMC5601171__F1 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy 6608 6469 5727 51684 2735 2736 2737 2305 9429 6657 10090 324 2932 PMC5605239__F6 Model for avoidance of APOBEC-induced lesions ahead of lagging strand DNA synthesis 2638 51455 170 PMC5605936__F1 Antiviral apoptotic pathways 8717 8772 3661 7098 8737 581 29110 PMC5607433__F5 Cytokine-cytokine receptor interaction 7124 6667 3569 2920 5008 7422 3791 3082 269 3572 4049 4055 3578 355 3952 3953 594857 85480 50604 1896 10913 5617 51561 7173 PMC5610024__F4 The dual role and therapeutic potential of high-mobility group box 1 in cancer 3146 7097 7099 PMC5610679__F1 Molecular events occurring in Alzheimer’s Disease (AD) following locus coeruleus (LC) norepinephrine (NE) loss and autophagy impairment 351 2475 2241 PMC5611503__F9 Signalling pathway of cytokine-cytokine receptor interaction signalling pathway 5008 1233 1950 1956 3977 268 3558 3815 4049 7852 4055 4050 10097 355 920 3952 6670 1232 85480 50604 11009 2057 2056 50616 1896 10913 2688 7216 4352 PMC5613881__F2 Regulation and signaling crosstalk of the Hippo pathway 4485 9113 26524 6010 324 1499 PMC5617549__F1 Molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer 5210 5209 2147 PMC5620322__F1 PRAS40 signaling in tumor 3667 7249 6009 5292 PMC5623821__F9 Self‐sustaining cancer cells in 3D 2621 3082 1956 5627 558 10461 7301 6714 2475 PMC5624830__F3 NOD1 and NOD2: beyond peptidoglycan sensing 7494 7186 10392 64127 23586 57506 3661 PMC5627415__F2 Epigenetic mechanisms currently associated with aortic VICs 650 4092 632 860 652 1499 100124700 4086 249 4318 4313 7040 4312 4323 4325 51548 7045 6696 PMC5634503__F7 Proposed mechanism 6120 7018 8031 5861 PMC5637726__F1 The role of the TGF-Beta-Smad and BMP-Smad signaling pathways in myocardial infarction and the mechanisms of some associated potential therapies 7442 3146 368 64388 6423 10097 4091 3399 3398 4090 4086 4092 4087 4088 4089 PMC5640931__F1 Simplified scheme of liver architecture and Wnt/ Beta-catenin signalling 5091 324 1499 PMC5640931__F2 The mathematical model 5091 1499 324 51199 PMC5640934__F1 TGFB superfamily signaling and its involvement in decidualization 94 90 7048 657 91 93 7046 659 658 269 130399 650 4086 4090 4093 4087 4088 4089 10468 PMC5642390__F6 The diagram of a potential signaling pathway that RACK1 regulates the cell proliferation and cell invasion in cervical cancer cells 10399 6772 595 PMC5645527__F1 WNT signaling pathway activation 4040 4041 324 2932 1499 960 6662 PMC5647233__F4 Hypothetical roles of ANTXR1 as a modulator of HbF expression 3043 3046 3048 3047 3044 3045 100187828 PMC5651170__F2 Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications 324 3932 7535 26191 PMC5651906__F8 PTP4A1 promotes TGFB signaling in DFs 4089 4088 8073 6714 7803 PMC5652964__F6 Proposed working model of ZZR on the Hedgehog signaling pathway-mediated MDR in colorectal cancer cells 6608 5727 51684 2736 2737 PMC5653149__F4 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer 4827 948 961 6714 5163 PMC5653513__F2 PD1-dependent inhibitory mechanisms 940 7535 5728 1017 4088 83737 PMC5656721__F3 Interplay in the synthesis and actions of the 2-acylglycerols and ethanolamides derived from ARA, DHA and EPA 63874 4099 26191 7442 9290 PMC5659938__F11 MiR-21-mediated suppression of Smad7 induces TGFB1 and can be inhibited by activation of Nrf2 in alcohol-treated lung fibroblasts 6774 4092 7040 PMC5661630__F2 Zinc deficiency in prostate cancer cells promotes cell survival via a phosphoinositide 3-kinase (PI3K) signaling pathway 5728 1019 5111 PMC5662566__F3 Integrin-linked kinase (ILK) signaling pathway is altered following RVFV infection 8440 5829 6251 7414 4666 51176 3875 1832 7431 650 PMC5663718__F3 Periodontitis caused by defective killing of bacteria 5340 6347 1233 PMC5664070__F3 An overview of signaling cascades involved in PLK1-induced EMT 5347 2305 2932 857 9839 6935 PMC5665033__F8 How arecoline affects glycolysis and the signaling pathway of anoikis in HA22T/VGH cells 3098 3099 387 PMC5665037__F2 Involvement of lncRNAs in the “adenoma-carcinoma sequence”, multi-step model of CRC pathogenesis 1956 1950 3845 55384 100124700 11191 324 1499 5728 4193 283120 101805488 5820 378938 9839 6935 3190 2475 999 643911 PMC5672917__F1 The role of iron in brain ageing and neurodegenerative disorders 7018 4345 4397 PMC5678971__F1 ULK/Atg1 redirects machinery used under vegetative conditions for stress-induced autophagy 9776 9706 9919 60673 PMC5681734__F1 NRG–ErbB signaling pathway 2066 3084 2064 2475 9542 2065 PMC5683051__F1 Interconnection between endoplasmic reticulum (ER) stress/unfolded protein response (UPR) pathways and mitochondria-NLRP3 inflammasome in allergic diseases 22926 83939 468 4508 3553 114548 PMC5683188__F1 Localization of key lipids and enzymes, designated by the genes encoding them, in different cellular compartments in S 5091 4099 1040 84249 PMC5683904__F7 Schematic to illustrate model of Wnt pathway 22943 4040 4041 2932 595 2302 1499 PMC5685770__F2 Therapeutic potential of cell cycle targeting in multiple myeloma 1163 1021 1019 993 999 324 991 1017 983 PMC5686110__F2 Signaling pathway of breast cancer download from KEGG website– with targeted genes and pathways from germacrone, curdione, and furanodiene 5966 3815 324 PMC5686390__F1 Mucosal-associated invariant T (MAIT) cell activation 324 3140 6295 3902 PMC5686903__F2 Over-expressed genes of Basal-like samples in p53 signaling pathway 1019 1017 472 545 355 637 4609 836 842 4193 64065 7249 5728 6477 64326 PMC5689704__F5 Screening circular RNA expression patterns following focal cerebral ischemia in mice 4092 166824 10207 154796 2932 4485 1499 324 9113 26524 3397 374 3398 174 2736 4609 6657 2246 329 332 85407 3689 PMC5696077__F3 Biosynthesis and Structure-Activity Relationships of the Lipid A Family of Glycolipids 3455 3454 114609 4615 114548 6772 3661 PMC5697091__F8 List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S 7097 5879 7124 54472 114609 10333 8772 3929 929 23118 51135 7189 7099 958 941 1513 130749 3661 7187 7098 4615 942 54106 PMC5697091__F9 List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C 2161 718 2147 2152 7450 2157 7035 2159 5340 1611 2 1431 727 1380 729 1361 735 2271 717 2155 2158 5091 730 PMC5698512__F1 IL-6 signaling pathways 6868 595 2475 79923 PMC5699945__F5 Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling, Loss of Lens Specific Markers, and Changes in Stress Response Proteins 11315 11332 26227 9709 2539 3162 2744 2944 2946 2950 218 PMC5700047__F8 Proposed model of CHK1 as a facilitator of transformation and drug target 4609 596 581 PMC5705392__F2 Immunobiology of the IL-15-IL-15RA Complex as an Antitumor and Antiviral Agent 3716 3718 6774 PMC5706502__F5 NcRNAs involved in mTOR signalling pathway 3480 3667 5163 5728 378938 7249 8649 283131 6009 64798 9776 PMC5706953__F1 KEAP1 glycosylation regulates the NRF2 pathway 8473 9817 8452 10724 23657 3162 1728 2730 2729 PMC5709760__F9 TGF‐B1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up‐regulation of IL‐17RB 55540 4087 4089 4088 PMC5711380__F7 Schematic summary of the IL-1B–IL-1 receptor signaling cascades identified in decidualizing human ESCs 2475 5971 4790 3603 PMC5712330__F3 Canonical and non-canonical NFKB signaling pathways 958 613 84433 4615 8915 7186 51135 10892 7189 7187 3654 329 330 81858 5971 5970 PMC5712330__F4 Regulation of the NFKB signaling pathway by MALT1 and BIRC3-MALT1 84433 10892 8915 7189 5971 7128 1540 330 7186 5970 PMC5713242__F3 Cilia-dependent Hedgehog signaling 6608 51684 374654 5727 PMC5715135__F7 Canonical pathway of molecular mechanisms of cancer from IPA showing dysregulated mRNA targets along with their potential differentially expressed miRNA regulators found in Lebanese samples 1398 2885 2922 85451 572 545 2444 4609 581 4149 100302203 847 51176 5933 51684 100423021 100126315 7471 PMC5715262__F3 Molecular pathways around CIC in cancer 23152 2115 595 894 100288687 25814 342371 PMC5716074__F1 “Prokaryotic Pathway” Is Not Prokaryotic: Noncyanobacterial Origin of the Chloroplast Lipid Biosynthetic Pathway Revealed by Comprehensive Phylogenomic Analysis 2875 4026 4018 PMC5716074__F7 “Prokaryotic Pathway” Is Not Prokaryotic: Noncyanobacterial Origin of the Chloroplast Lipid Biosynthetic Pathway Revealed by Comprehensive Phylogenomic Analysis 4018 5091 95 355 PMC5716183__F1 One-carbon metabolism, transmethylation reactions and DNA demethylation 4524 4548 635 191 4144 27430 4616 PMC5716985__F1 Mechanism of epithelial-to-mesenchymal transition (EMT) 3082 1950 1499 2303 999 1000 PMC5722815__F6 BMP2 or BMP6 signaling enhances adipocyte function 4091 4092 4090 4086 4089 3399 3400 3398 3397 5468 2194 3952 6256 PMC5726441__F1 PI3K pathway in human disease 717 5266 1443 8821 5728 5163 695 3702 7006 100124696 7249 7248 6009 6010 PMC5727869__F10 The function mechanism of HER2-HER3 co-expression 23178 2475 6774 PMC5729307__F2 Pathway signalling starts with the binding of insulin or growth factors to insulin receptors 5163 5728 6009 PMC5729346__F1 The abnormalities in the pathway of tyrosine metabolism in tyrosinemia type I 5053 3242 3081 2184 PMC5729474__F4 The highlighted metabolic alterations in leiomyomas of the FH and MED12 subtypes 3162 2271 158 9968 PMC5731874__F6 Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells 960 7104 6714 6774 2932 1499 PMC5732234__F2 The immune deficiency (IMD) pathway in fruit fly and the TNF pathway in the mouse 7124 8772 7186 5966 5970 PMC5734142__F1 Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer 5979 983 1021 1019 1017 PMC5739444__F7 SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation 6722 6010 22933 PMC5741148__F1 Regulation of the FoxO1/3 activity by phosphorylation 5163 8471 3667 8660 2308 2309 2152 PMC5743035__F8 Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters 2937 3156 1717 PMC5743847__F1 Lipoquality control by phospholipase A2 enzymes 4512 4049 4050 27306 5228 PMC5746039__F6 Glycolysis and its branching pathways 3099 3098 355 3939 3945 PMC5746105__F16 Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury 735 3426 4179 731 7450 5589 3856 1508 1540 1650 3273 11057 5062 5270 3710 830 5698 2730 54361 2949 8837 11343 2053 9111 3158 33 10216 3991 6387 1054 11001 2181 2690 28965 8743 2173 1962 5168 1622 3460 5562 3563 57817 366 3550 2266 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9447 383 4843 3661 PMC5762387__F5 MEF2 signaling and human diseases 6423 1956 5335 5331 1499 4205 4208 4209 100271849 PMC5763468__F2 MCF7-related generic pathway map 3643 1956 5163 2475 3065 472 672 572 596 5347 6241 PMC5763468__F4 MCF7-specific signaling pathway network inferred by TILP model 3643 1956 5163 3065 2475 472 672 572 596 6241 5347 PMC5763539__F4 Pathway map for “Inhibitory PD-1 signaling in T cells” 920 940 847 5728 6850 7409 2475 1017 6502 5447 4088 PMC5764090__F2 HiJAKing the Epigenome in Leukemia and Lymphoma 3717 3566 4609 3716 4615 6774 4791 4792 3662 1958 64332 9021 10538 597 6446 3725 PMC5765398__F2 Mucosal tolerance in the gut and its breakdown in food allergy 1378 3394 6778 3566 920 2625 3662 8829 1524 2205 PMC5766484__F4 Expression of key biological pathways involved in M 100187907 83876 6955 811 759 4025 7008 PMC5768915__F1 HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway 3953 2263 6774 6657 6662 PMC5771206__F6 Intramuscular fat metabolism 7069 4023 2167 2170 1376 PMC5772929__F1 Mechanism through which metformin exerts its antitumor effects (A) by reducing the level of insulin in serum to inhibit the PI3K/Akt/mTOR signaling pathway and (B) by activating AMPK to inhibit the mTOR pathway 7249 7248 6009 2475 572 595 PMC5773404__F2 Synaptically Localized Transcriptional Regulators in Memory Formation 9759 23373 266743 23237 3164 627 PMC5777172__F2 Regulation of hepatic glucose metabolism in health and disease 2642 3643 2645 5140 PMC5779720__F4 Flux distributions simulated with lMOMA for the mevalonate mutant (A) and the acetate mutant (B) using the improved flux distribution as the reference 5091 5132 4118 11113 51430 PMC5786553__F1 Fatty acid synthesis in Mortierella alpina 3992 1674 283985 1896 2717 PMC5787446__F3 Drug resistance related to aberrant glycosylation in colorectal cancer 2030 6573 85320 540 717 5243 4363 1244 9429 1066 8824 4524 2068 2067 7515 PMC5791065__F1 Activation of the B cell receptor signaling canonical pathway in FCRx versus SIS: a schematic representation 933 930 2885 5728 6850 4067 1445 998 695 54518 29760 2475 83593 572 85451 2308 1879 6929 1958 2113 604 5079 PMC5794012__F4 An overview of the main metabolic pathways affected by the storage lesion in RBCs during routine storage in the blood bank 27040 3263 84890 4118 PMC5794417__F8 Schematic diagram on regulation of PCSK9 on apoB via modulating the autophagy pathway affecting atherogenesis 255738 338 2475 8408 22863 9474 PMC5794831__F1 KEGG NFKB Signalling Network with dysregulated mRNAs highlighted and their associated miRNAs included 723778 693168 472 27040 29760 613 6850 406986 4067 7189 331 100500877 8717 7186 23321 23586 3929 929 114609 4513 695 7099 1270 4803 7187 100126324 4049 4050 4055 1610 3553 717 100616321 PMC5795269__F1 Nicotinamide adenine dinucleotide biosynthetic pathway 10135 23098 952 95 PMC5795460__F1 Only the classical role of the Fanconi anemia (FA) pathway in the repair of interstrand cross-links (ICLs) is depicted, which involves highly coordinated protein–DNA and protein–protein interactions in the nucleus 2189 2176 545 2175 2188 2178 472 2187 57697 55120 55215 2177 PMC5795989__F1 BMP-triggered signalling pathway and major regulators 25805 4091 4092 64750 57154 6010 4090 4086 3611 4089 7018 PMC5797067__F1 Exon 3 mutations of CTNNB1 drive tumorigenesis: a review 2932 8312 8313 324 847 7008 PMC5799794__F1 Effects and underlying mechanisms of lncRNAs in various fibroses 7040 440823 55384 100505854 5045 1580 4088 55728 91584 1080 9839 4615 PMC5800786__F4 Metabolic Regulation of Immune Responses 3575 940 7189 8011 2475 PMC5803917__F4 AP1 and CEBP mediated skin barrier impairment by BM 960 207 846 3725 1051 5586 2534 5290 5335 7018 6667 PMC5808457__F1 Tumor Suppressor Candidate 2 (TUSC2; FUS-1) and Human Cancers 11334 4193 1956 5159 PMC5809759__F1 Can Controlling Endoplasmic Reticulum Dysfunction Treat Allergic Inflammation in Severe Asthma With Fungal Sensitization? 22926 7494 468 PMC5810418__F8 Large Wnt Pathway solutions 324 4040 1499 7091 6925 7089 PMC5811339__F1 Hydrolytic enzymes tested in this study participate in sphingolipid metabolism in the lysosome as indicated by their respective gene names (blue) 2720 2717 2581 PMC5811627__F1 Outline of main altered pathways in pancreatic neuroendocrine tumours 2475 1616 546 5623 11200 5728 4221 672 675 9681 79728 7249 7248 5888 29072 4595 58508 196528 2313 6597 2130 139105 7428 PMC5811677__F3 Key signaling pathways affected by CD5 expression 6850 4067 7409 2475 921 6772 6774 PMC5811730__F3 Rationale for targeting both the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways for suppressing cancer growth 1956 126669 2885 2475 572 4193 10743 PMC5813884__F5 Nitrogen regulation of the GAAC pathway 4553 1998 83939 997 PMC5814196__F1 Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer 100302142 100500918 693168 100616321 100616189 100847075 51701 723778 147111 9350 4040 324 4089 4088 25805 50964 6500 8454 6477 406909 100302188 387 27130 PMC5817353__F1 Subcellular compartmentalization of the Fe-S cluster and Moco assembly processes 9054 23479 112812 2230 64210 57019 9391 7498 200205 81689 122961 100187761 22 552900 51027 4338 27304 4337 6821 PMC5817726__F2 Role of Bruton’s tyrosine kinase downstream of the B cell receptor 613 930 4067 5728 6850 5266 695 5336 5163 8915 84433 5894 10892 4609 2002 PMC5817727__F4 Regulation of PTEN, a major regulator of the PI3K/AKT signalling pathway 5163 5728 1958 1386 101243555 PMC5817803__F2 ALK signaling pathway 238 6608 5787 5803 2735 2475 572 PMC5818366__F1 “cross-talk” between liver and peripheral organs in the pathogenesis of NAFLD 181 4852 5443 80339 PMC5820294__F1 Signaling pathways involved in the progression of extramammary Paget’s disease 367 2475 1021 1019 1233 7852 6361 1000 PMC5822876__F6 Rheumatoid Arthritis-related molecular signaling pathway 6352 4088 1386 PMC5824531__F1 Signaling pathways linked to Insulin/IGF signaling in PDAC 3481 3480 5163 5728 23216 572 596 9882 2308 PMC5824774__F5 Result of ‘Networks’ query way 10128 2066 5880 10273 2885 4149 10507 3717 5566 55914 27040 2065 8065 3570 5978 3265 7314 7032 6233 7031 7039 11140 4609 3569 145957 5604 6047 2069 5879 6464 9542 388 6868 27289 1956 391 4893 1950 100187761 PMC5826318__F1 Host-secreated miRNAs regulate the gut microbiota that in turn affects the host via induction of specific miRNAs 6774 5728 9619 19 857 596 619501 PMC5828319__F2 Inhibition mechanism of IL-12 production through interaction of TIM-3 and Gal-9 7099 4615 6714 51135 7006 100124696 6772 6774 7189 PMC5829268__F2 Schematic demonstration of TCR signaling 27040 2885 7535 3558 2353 3725 PMC5830185__F2 Current evidence on statin use and prostate cancer prevention: are we there yet? 6010 1950 1017 2475 PMC5831777__F3 Hh signaling within the developing TMJ 860 5727 6608 2735 8643 3549 2736 6662 1280 1300 2737 PMC5831902__F3 The calcineurin/NFAT signaling pathway and the miRNAs involved in feedback loops to modulate the pathway activities 84876 6786 3708 9455 9495 10454 120892 23118 1859 PMC5831949__F3 Key biological pathways with DNB genes in cytokine-cytokine receptor interaction and PPAR signaling pathway 7124 6370 3791 3626 1950 3976 729230 268 4049 1271 355 6368 121340 6420 3953 6347 1896 10913 2690 2689 5618 4352 3611 7316 5281 55540 5008 3623 9180 3574 920 4351 6476 3952 7292 29949 85480 PMC5832878__F7 DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/Beta-catenin pathway via GSK3B 324 2932 1499 595 PMC5833577__F3 Signaling pathways of neutrophil necroptosis 7124 8717 11035 8737 197259 8772 PMC5833577__F4 Necroptosis signaling by TNFR1 stimulation via TNF 7124 8717 8737 8772 11035 197259 PMC5833784__F2 Immunological consequences of kidney cell death 8737 197259 11035 PMC5834520__F1 Osteopontin in the progression of solid organ tumour 1758 1834 581 PMC5834520__F2 Osteopontin in the progression of solid organ tumour 1950 960 1956 5728 3091 PMC5836070__F2 Ethanol indirectly interferes with DNA integrity by affecting key points (labeled in red) or enzymes in folate metabolism 1719 635 4548 4524 PMC5837124__F3 Various strategies to target Myc 1022 23476 1025 7874 4609 4149 6790 5347 PMC5837202__F3 Effect of PCB126 exposure on the calcium signaling pathway 90550 5350 3371 857 858 859 613 4827 952 PMC5838194__F3 Gene ontology enrichment of relate 16 key genes to the PPI network of NAFLD rat after fat diet feeding is presented 1666 47 31 32 5594 7124 3630 213 6714 PMC5840025__F9 Cell-specific requirements for STAT proteins and type I IFN receptor signaling discretely regulate IL-24 and IL-10 expression in NK cells and macrophages 6778 6775 6772 6774 PMC5841936__F2 Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling 912 1445 717 2534 3932 113633881 PMC5841936__F3 Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling 1445 3458 3558 717 8178 PMC5842951__F1 Rho kinase signaling and cardiac physiology 6093 9475 6722 80206 387 PMC5850680__F1 Under the action of BMP2 and inflammatory mediators such as tumor necrosis factor, the expression of transcription factors Runx2 and osterix can be activated via the BMP/Smad pathway 1401 650 7124 4037 860 4488 4040 PMC5850959__F6 Transcriptomic data shows immunometabolic effects of vitamin D 1431 50 3033 4191 2271 3420 6389 6390 6391 6392 4967 1743 8802 1738 8801 3419 3421 PMC5850959__F7a Transcriptomic data shows immunometabolic effects of vitamin D 375 8243 9184 2033 7040 5591 545 2932 472 4088 4089 7529 7531 7532 7533 7534 324 894 891 8900 27040 25 3065 3066 51564 9759 1869 2147 718 4221 1874 10971 902 1021 729 8841 55869 730 PMC5851329__F4 Summary of Potential Eph/Ephrin Tumor Promoting Pathways 6774 999 2534 2064 5728 1499 6010 3717 5879 PMC5851908__F1 Regulatory network for p42.3 involvement in tumor cell apoptosis (red pathway indicates the maximally possible acting pathway) 6282 581 6093 10519 7186 5058 572 6275 6285 6273 PMC5851908__F3 Regulatory network for p42.3 involvement in colorectal cancer cell apoptosis (the red pathway indicates the possible acting pathway for p42.3 involvement in cell apoptosis) 324 1499 572 842 4193 581 836 1630 5728 51741 PMC5851940__F1 Biological pathway of Leukocyte Transendothelial Migration () 387 5880 8480 7006 100124696 399 7070 83700 10766 58494 5879 4267 PMC5851940__F5 Highlighted genes to represent a single pathway 387 5880 998 5879 7006 100124696 399 3676 3688 3683 3689 3684 7852 PMC5852553__F10 Actin cytoskeleton signaling pathway in Cobb chickens 3929 1950 2885 55970 2316 1398 387 1793 5829 324 10724 10458 3932 7414 2934 7204 10152 PMC5853489__F3 DAL81 regulates expression of arginine metabolism in C. parapsilosis 384 1358 1357 383 PMC5854428__F2 Viral manipulation of STAT3: Evade, exploit, and injure 6774 3716 10155 9021 5789 5091 3717 PMC5856858__F1 KEGG Apoptosis pathway with highlighted dysregulated mRNAs and miRNAs 6418 4170 8772 8544 7186 1616 790 8717 3550 840 468 9049 637 27429 4199 572 8739 6964 835 PMC5857409__F4 Proposed potential therapeutic targets in Erythroleukemia 2057 238 63928 PMC5858488__F1 MTOR signaling pathway 1956 5728 7249 7248 253260 2475 64223 PMC5858900__F1 Multifaceted Fanconi Anemia Signaling 57697 641 91442 25859 2176 2175 2178 55215 2177 PMC5859872__F2 Cooperative interactions between the tumour and surrounding cells in tumorigenesis 4312 4313 23513 1956 2353 PMC5859872__F3 Non-cell-autonomous overgrowth 474168 23513 84313 7251 PMC5860944__F2 Epidermal growth factor receptor (EGFR) and EGFRvIII in glioblastoma (GBM) 1956 3976 4763 5728 5111 PMC5861627__F3 Crosstalk between Shh pathway and others 6608 1956 6469 4041 4040 7048 1950 7046 51684 324 5290 3815 3845 2932 5728 1499 673 2736 56914 572 374654 2475 2689 PMC5865411__F8 Proposed model for the novel dual functions of toll-like receptor (TLR)-10 in regulating IFN signaling 7098 81793 23098 3665 4615 PMC5866017__F6 Enriched pathways in cholangiocarcinoma 3065 5591 8480 5928 142 10537 6595 8570 55832 1871 1958 2908 898 4173 2597 4176 4171 7514 2534 11284 2783 7533 4172 5894 9138 7186 2896 5879 6955 2353 5764 51588 2146 4841 3627 2634 4734 842 5447 PMC5866458__F1 A change of view: homologous recombination at single-molecule resolution 6741 5888 11144 PMC5866851__F2 Visual description of the IL-31 and IL-33 cascades leading to the activation of the genes and the proteins involved in the development of inflammatory disorders 90865 6761 9180 4615 51135 6352 6361 6369 7124 6347 6348 2920 PMC5868363__F11 Possible cellular mechanisms involved in calycopterin-induced apoptosis in HepG2 cells 581 596 317 PMC5868586__F7 Schematic illustration of the underlying mechanism of L61H46’s anticancer activity.Abbreviations: IFN, interferon; IL, interleukin 3717 3716 6774 6773 6772 PMC5869528__F10 Cytokine-cytokine receptor interaction signaling pathway 7124 1437 10097 3977 5008 3625 3791 2324 6363 6366 1950 268 729230 3815 2322 4049 3565 6348 4050 56832 355 1441 978 3952 6420 1232 85480 6846 50604 2056 50616 1896 10913 149233 51561 7173 55801 100187761 3976 4055 655 29949 3569 PMC5872689__F6 Suggested mechanism of pinitol-induced effects on the insulin secretion pathway 3586 790 720 PMC5874051__F3 Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri 56624 64781 57704 2720 PMC5876234__F10 Lico A-mediated Nrf2 signaling pathway protects APAP-induced ALF via inhibition of mitochondrial dysfunction and apoptosis 9817 2729 2730 4094 351 PMC5881178__F4 Metabolomic differences associated with Wnt1-initiated tumors 4015 7471 1036 PMC5882218__F1 Models of the Hippo pathway in mammals 4485 60485 9113 26524 PMC5884111__F6 Cartoon schematic showing the mTOR signaling pathway in cells 1956 5728 7249 7248 6009 PMC5886582__F5 Signature pathway expression of xylose utilization in the genetically engineered industrial yeast Saccharomyces cerevisiae 5236 5238 55276 2203 64434 6886 7167 5230 2026 2023 131 128 127 100996949 5131 48 50 3417 5105 3418 4190 4191 PMC5890151__F2 Treg likely promote tissue repair and regeneration in a tissue-specific manner 374 6351 6348 90865 1956 6387 6367 PMC5890159__F1 Nutrient activation of PKA in the yeast 2695 5997 201626 PMC5891174__F3 Crosstalk of DNA double‐strand break repair pathways in poly(ADP‐ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2‐mutated cancer 672 55183 3981 5888 675 PMC5893168__F7 Signaling pathway predicted to be activated by the miRNA target predictor of IPA 4353 3577 4703 3383 7412 790 384 4513 126669 PMC5893845__F6 Schematic diagram on the transcriptomic profiles of metabolic pathway genes involved in the enhanced MCFA production of mutant cC14TE_B3 D 2695 5132 9541 3033 95 PMC5897459__F2 Biosynthetic pathway of thylakoid glycerolipids from phosphatidic acid (PA) in Arabidopsis thaliana 1040 8760 283871 101448070 PMC5899637__F1 Drug resistance in HER2-positive breast cancer brain metastases: blame the barrier or the brain? 5728 5163 7248 PMC5901476__F1 Mineral and bone disorders in chronic kidney disease (CKD) 5741 8074 22943 PMC5901476__F3 Proposed mechanisms by which PTH activates Wnt/Beta-catenin pathway in osteoblasts and osteocytes to modulate bone turnover 5741 1499 2932 PMC5902856__F4 Comparison of phospholipid (PL) synthesis and lipoprotein (LP) formation pathways between 0.16, 2.5 and 10 g salmon 780904 283871 56994 10400 23761 57107 5549 948 335 PMC5904768__F3 DNA damage stress response in the TRIM59 network 4194 472 545 28996 4193 11200 9320 79866 6790 2033 7834 56475 7465 PMC5905598__F4 Genes of complexes coding for the mitochondrial oxidative phosphorylation and tricarboxylic acid cycle (TCA) 717 4700 4704 4711 51300 4714 4720 51805 23530 6392 2271 4191 1431 4200 3418 PMC5907676__F3 Cross-talk between Wnt and signaling pathways 2475 2932 2146 1499 6477 101805488 PMC5910217__F2 Interferon system 3455 3454 7297 3716 6773 57506 10379 115004 3661 3665 PMC5912970__F2 Genes affecting progression of bacteriophage P22 infection in Salmonella identified by transposon and single gene deletion screens 2733 51083 2582 101448070 PMC5915057__F4 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer 57724 133418 317649 2353 2886 6659 65108 92312 9315 6915 9891 6272 8303 5175 6402 3728 604 2185 1950 5879 7494 1647 1009 11009 928 1903 3592 7022 5155 929 6237 998 1436 2261 2549 5287 3691 3667 5296 56034 3688 1846 8912 7074 317 PMC5915057__F5 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer 4325 80781 6347 8728 8842 7001 1376 1491 594 1191 7168 283120 192 5264 79170 23286 4763 9532 2632 4651 6047 9314 7050 991 5557 8231 2004 2120 3726 4791 4609 7421 80139 5087 9918 259266 3397 58527 79191 4601 602 1051 7298 7494 4172 2119 4781 7832 10714 54626 5434 5983 84667 5424 4286 5111 468 51659 5558 4088 1649 982 641 9212 2232 64393 4312 4397 80763 4282 3801 178 10682 8178 2353 7621 3725 23649 1062 595 9134 10592 9262 4051 8870 PMC5915062__F2 Proteomic alterations in early stage cervical cancer 871 11143 11169 8125 55684 5981 8317 2237 5424 5925 4175 9768 5927 4173 6286 79892 4172 4999 7849 2099 84823 9373 3607 7494 7150 7175 10961 5108 PMC5915062__F3 Proteomic alterations in early stage cervical cancer 9373 51752 2923 6890 10135 5698 811 4928 4057 9972 4171 7175 11169 4174 4175 9688 4173 8243 4172 9126 23450 3122 1654 60626 PMC5919742__F7 Cell-type expression patterns of carbon metabolism-related genes in V 52 53 2203 80146 5239 4155 9827 5106 5105 1891 3417 10724 4142 2695 100307118 100307119 3418 PMC5920280__F1 Metabotropic actions of kainate receptors (KARs) in the regulation of glutamate release in the hippocampus 759 761 4827 PMC5920380__F1 Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway 374654 2736 51684 6608 2737 8405 2735 2932 PMC5923348__F3 Intricate relationship between CD30 and AP-1 in Classical Hodgkin Lymphoma (CHL) and Anaplastic Large Cell Lymphoma (ALCL) 7186 7187 10538 3726 PMC5923353__F1 Lytic cycle proteins contribution to tumor initiation and tumor maintenance through enhanced survival, inflammation and immunomodulation 3603 7852 6387 4513 3553 PMC5923365__F1 Cellular pathways affected by genes significantly mutated in ALL 2322 2885 5781 867 673 369 1956 10019 4193 2475 472 7249 1499 5728 PMC5924972__F1 Saikosaponins and implications for age-related diseases 6741 404713 114548 23410 PMC5927358__F3 Wnt/TOR and Wnt/STOP signaling pathways 324 7249 4040 4041 2932 PMC5930388__F5 PI3K/AKT/mTOR pathway 5728 5163 7249 7248 PMC5930467__F6 Verteporfin in bladder cancer cell 4485 60485 9113 26524 27063 PMC5931986__F3 Nucleolar response to nuclear or nucleolar DNA damage 472 9656 27343 11201 8555 4869 4691 324 999 5347 545 PMC5932189__F3 Myeloid C-type lectins and heterologous receptors 4615 6850 2475 64170 4193 3659 PMC5932495__F2 The role of inflammasomes in Parkinson's disease and Alzheimer's disease 1508 7097 114548 1020 3603 338322 4615 PMC5940378__F7 Proposed aPPD anti-prostate cancer mechanism 367 581 4193 PMC5940740__F2 Diabetic stressors lead to Schwann cell dysfunction and neurodegeneration 50846 1270 3479 572 6010 PMC5945496__F6 Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells 9817 3162 673 3265 23657 8714 2810 7295 7296 2730 PMC5949883__F2 Network of metabolic pathways that regulate leukemia 4609 5728 7249 7248 PMC5951297__F4 Identified pathway between EGFR and JUN for Loi’s breast cancer dataset 1956 5594 3932 367 898 25 7157 4087 4089 405 8648 3725 PMC5951828__F6 Potential role for AstC-R2 in nociceptor-bacterial-immune interactions in Drosophila 8989 759 878 PMC5952217__F1 A schematic illustrating some of the factors proposed to affect obesity and carcinogenesis 2475 6774 3717 1499 3569 3458 3553 196 406947 355 2859 PMC5952217__F2 Kynurenine pathway is initiated by the oxidation of tryptophan via the enzymes IDO and TDO, with downstream catabolites having toxic, antioxidant and cell-protective activity 325 3569 1499 3458 8564 196 PMC59539__F1 The Hh signalling pathway, based on what is known in flies 6608 51684 717 PMC5960217__F3 Wnt signaling in hematopoietic stem cells and early B cell development 10113 100133941 8326 PMC5961736__F3 Apoptosis signaling pathway that contains effective therapeutic targets in lymphoma 7124 8717 8772 4609 4193 637 581 596 545 472 PMC5963164__F7 Prostate cancer pathway enriched in KEGG 367 5728 1017 572 4193 596 2475 2950 2444 PMC5963164__F8 ERK/MAPK signaling enriched in IPA 2885 1398 2534 6714 5829 1793 369 4342 5091 7444 572 1977 2002 466 6722 PMC5964132__F4 Multiple signaling pathways are upregulated in MCF7 parathyroid hormone-related protein-overexpressing cells 2334 2069 374 282969 367 168667 53918 PMC5966753__F7 Action of testosterone (T) in inducing hepatic steatosis/steatohepatitis 22926 7038 8694 355 83939 7494 7186 5465 1374 PMC5968182__F1 Hypothetical roles of linear and circular ANRIL lncRNA in regulating inflammation and cell survival in human vascular endothelial cells and potential drug targets 23481 3569 7528 PMC5968387__F8 Signaling pathways that are postulated to upregulate the expression of A20 and then inhibit inflammatory mediators in macrophages induced by M protein following GAS infection 4615 7189 3603 3553 PMC5968744__F1 Schematic representation of the signal transduction pathway of ATF3 protecting against I/R-induced inflammation, apoptosis, or myocardial injury in various organs 7018 467 3065 4703 PMC5969551__F2 Role of Cic in Ras-MAPK signaling and growth control 23152 875 4485 26524 7003 8463 7004 7005 PMC5969912__F3 Once and only once: mechanisms of centriole duplication and their deregulation in disease 4193 26524 835 5879 57646 PMC5971462__F9 Smooth muscle cells differentiation process 4089 4092 7040 9475 PMC5972910__F11 Putative role of Wnt signaling pathway during BoHV-1 latency-reactivation cycle 10000 1499 11197 PMC5974615__F1 Regulatory Network of ARF in Cancer Development 1021 1019 4193 PMC5979412__F3 NFKB-Mediated Inflammation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Does Autophagy Play a Role? 5971 5970 2475 PMC5979467__F3 Survivin regulation 1956 3480 1499 4193 2475 1431 PMC5979829__F8 LIF and the PI3K/Akt signaling pathway 3976 6926 79923 PMC5980113__F6 Role of MICAL1 in breast cancer cell proliferation 64780 1499 1019 PMC5983129__F7 Cisplatin treatment to the induction of apoptosis 467 468 1017 PMC5983591__F1 Growth hormone releasing peptide (GHRP)-peroxisome proliferator-activated receptor-gamma (PPARG) pathway in lipid and energy metabolism 948 3638 19 9619 348 PMC5983636__F1 Mammalian target of rapamycin (mTOR) signaling pathway 5728 5163 2475 64798 253260 7249 7248 6009 8408 PMC5986469__F8 The interaction effects of enriched KEGG pathway terms and putative target proteins identified in the present study 3416 3558 348 1956 213 7276 5600 2147 4314 351 5602 4129 5340 735 5604 6714 3265 2260 4846 3320 1017 968 7124 PMC5988573__F1 Schematic diagram showing the positive feedback loop between Hippo-YAP/TAZ and IRS2-AKT signaling in the DKO livers 5728 8660 324 PMC5988607__F1 Signaling network of MST1 and MST2 kinase 55233 92597 9113 26524 2309 PMC5988607__F3 Regulators of MST1 and MST2 9113 26524 4018 717 4485 PMC5990418__F3a Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV 572 2308 5728 PMC5991413__F1 Unsolved mysteries: How does lipid peroxidation cause ferroptosis? 2879 10162 2182 PMC5992605__F7 Schematic model describing the molecular responses to SIL1 loss in skeletal muscles leading to myopathy 3480 2475 1647 64374 PMC5993211__F1 Innate Antiviral Immunity in the Skin 3717 7097 6772 6773 7187 29110 57506 10379 3665 3661 3659 4938 3437 4939 3433 9636 1660 3434 PMC5993794__F3 Ingenuity Pathway Analysis of SNX8, PCP2, KNG1, and RORA 257364 51429 6095 29886 100847059 PMC5994774__F2 Scheme of PI3K/Akt/mTOR pathway depicting both complexes mTOR protein takes part in, mTORC1 and mTORC2 5728 5163 7249 1977 7248 6009 2475 64798 9675 PMC5998874__F3 Hypotheses of dysfunctional regulation mechanisms of gastric carcinogenesis around XBP1 7494 2627 51303 768 84152 6714 7852 2475 6774 466 596 PMC6000455__F1 mTOR信号通路mTOR signaling pathway 1950 3479 3667 5163 7249 7248 5728 6009 1977 PMC6002380__F4 NOD-like receptor signaling pathway 7205 64127 64170 10454 6347 23118 257397 834 9054 PMC6002427__F3 Signaling pathways in mast cell biology 3815 27040 6714 6850 4067 2885 3717 PMC6003946__F12 SLIT2-ROBO1/ROBO2 and the CDC42-RAFs-ERK1/2 MAPK cascade 9353 6091 6092 2492 57522 5063 5062 5058 2661 6770 1583 PMC6008051__F5 Network interactions of transcription factors predicted to be upstream of differentially expressed skeletal muscle genes 4654 1499 6597 5925 3091 7125 85366 7422 2660 PMC6008657__F3 Insulin signaling also controls mTOR pathway that inhibits autophagy 9474 9140 8408 2475 9776 PMC6011061__F1 The Keap1/Nrf2 pathway and its epigenetic modification by SFN 9817 8452 4094 1728 2810 9759 PMC6013567__F2 Activation of the anticipatory unfolded protein response by estrogen receptor A (ERA) 1938 83939 29904 PMC6014344__F3 TGFB/Smad classic pathway 4087 4088 64750 4089 4092 6497 PMC6018060__F2 Macrophage Phenotype in Regulating the Response to Radiation Therapy 3566 2625 3596 6778 6774 PMC6023766__F2 Control of the PI3K and RAS signaling pathways by phosphatase signaling 2885 5163 5164 5728 PMC6024333__F2 Mechanisms of innate and acquired resistance to immune-checkpoint inhibitors (ICPIs) 3717 3716 1499 8205 PMC6025008__F4 ER stress and the UPR in insulin resistance and diabetes 3375 3569 468 83939 7436 7494 PMC6026692__F2 Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation 3553 3146 7099 54106 3383 7412 9927 PMC6027047__F1 Metabolic activation of aristolochic acid I (AA-I), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 5-methylchrysene, and tamoxifen are shown as prototypes of procarcinogens 1728 5447 55023 3416 PMC6028303__F2 Revisiting antipsychotic drug actions through gene networks associated with schizophrenia 5045 4192 6925 10000 783 2033 1813 6721 6237 6720 219541 4208 5764 1463 9162 PMC6030085__F7 SOX17-mediated disruption of Wnt/beta-catenin signaling 2932 1499 64321 PMC6031075__F1 Putative model of the functions of HSPGs in CRC cells 1499 6854 2821 PMC6032252__F1 The tumor microenvironment on myeloid cell differentiation and metabolism 941 942 3976 3082 8205 6280 3977 29110 PMC6033032__F2 Schematic/pathway representation of the FOXO‐p53 interplay in cellular senescence 472 2308 2309 2152 4303 PMC6034042__F4 Nicotinamide Adenine Dinucleotide (NAD+) synthesis pathways 10135 952 93100 PMC6034647__F1 From mice to men: TRPC3 in cerebellar ataxia 2747 7222 773 5582 5173 6310 PMC6035044__F2 Prolactin Regulation of the Prostate Gland: A Female Player in a Male Game 3717 5617 367 595 PMC6036268__F6 Pectin oligosaccharides (POS) downregulates the expression of nuclear factor-kappa B (NFKB) and COX-2 by binding toll-like receptor 4 (TLR4) 7099 7097 7098 7100 4118 4615 29110 3654 7124 PMC6036613__F3 NFKB pathway induced by LaW37 in Caco-2 cells 1950 7039 4803 4049 958 4055 3932 7535 10454 65125 5970 5971 7124 5336 84433 PMC6041899__F7 Quercetin inhibits gastric cancer metastasis 4318 5058 4313 3984 PMC6043790__F1 Phospholipid synthesis pathways 5091 84249 3630 1040 PMC6044036__F2 SAM treatment during hepatocarcinogenesis 4609 1843 328 3569 7874 PMC6050903__F1 Regulated cell death signaling pathways 142 2879 8737 11035 3553 PMC6053276__F1 A simplified representation of the HIPPO pathway 4771 60485 4485 9113 26524 PMC6055056__F5 Signaling pathways involved in susceptibility to Salmonella enteritidis infection 3667 80854 3643 7852 5159 9454 5154 1956 4804 3551 3606 604 8718 23766 8792 3588 1387 10803 5293 655 3597 595 3587 9063 51588 8651 3556 PMC6059011__F1 EV Biogenesis and Interaction With Recipient CellsExosome formation starts with endocytosis, a process in which the cell membrane is pinched inward and captures bioactive molecules, resulting in the formation of the endosome 7251 7879 382 5874 5873 11031 PMC6059692__F4 Predicted regulatory networks affected by sinomenine treatment via Ingenuity®Pathway Analysis 196 7040 1473 2263 2328 1303 5933 253260 9188 23348 375056 9631 23 10157 6749 PMC6061042__F3 Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes 4199 9415 4023 6418 1375 PMC6063270__F6 Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution 51083 5236 55276 PMC6064203__F4 Integrative machine learning analysis of multiple gene expression profiles in cervical cancer 1163 27258 10935 5426 9700 9276 5887 6526 890 4173 701 PMC6068015__F1 Lymphoma immune evasion mechanisms 914 355 965 940 941 942 3902 3135 961 100188811 140885 1233 PMC6070639__F2 PA induces the upregulation of PGC-1A expression via multiple signaling pathways 3479 7019 2876 2475 4899 5225 PMC6071809__F6 Proposed signaling pathways implicated in the promoter-specific expression of CYP19 in Hs578t cells 5594 5595 2002 6774 PMC6073358__F9 Signaling pathways were regulated by HSAF 2932 1021 1019 PMC6073455__F4 SCF and its active ingredients protect against inflammation in NDs 7124 7099 54472 8772 4615 8717 7186 7189 8195 PMC6081569__F10 Nuclear effects of DRD1/PKA pathway and reactive species on postsynaptic neurons 2354 2002 11201 1020 PMC6082928__F6 Signaling pathways engaged by the LMP2A gene 613 2932 1499 PMC6085483__F2 Metabolic reprogramming of cancer cells in the tumor microenvironment (TME) 207 3091 2475 2744 57103 5728 9997 4609 PMC6087481__F1 Type I IFN-dependent pathway and ER stress response-induced pathway of IFNAR1 degradation 7297 5311 3454 PMC6087673__F1 Apoptosis in Acetaminophen Hepatotoxicity 355 8772 581 637 790 PMC6088794__F1 Androgen receptor signaling axis and potential androgen-dependent and independent mechanisms of disease progression 367 5728 2475 4193 PMC6089768__F11 miRNA-145 inhibits myocardial infarction-induced apoptosis through autophagy by Akt3/mTOR signaling pathway in viv and in vitro 10000 2475 9474 PMC6089851__F1 Major RAS family numbers 6010 5901 9886 375 377 378 23221 22836 382 400 54509 391 402 403 399 57381 23433 84100 58480 171177 27289 132946 8153 390 5879 5880 5881 998 115761 200894 80117 339231 54622 373 379 10139 6009 3266 5906 2669 6014 22808 6237 5911 5912 28954 121268 22800 148252 54769 57826 28512 28511 9077 161253 51655 23551 10633 387496 65997 91608 85004 51285 381 390790 PMC6090282__F13 Signaling pathways activated by temozolomide in glioma cells 7220 6714 2475 4255 3725 2353 PMC6091082__F3 The applied conditions on the expression of central metabolism genes 1896 7086 100034700 2695 5371 417 6389 84890 355 6120 275 PMC6092617__F7 Targeting prohibitins at the cell surface prevents Th17‐mediated autoimmunity 11331 5245 50943 3605 PMC6092802__F7 DNA Damage Response (DDR) Pathway 5884 5810 3364 9656 11073 672 11200 1111 PMC6093675__F6 Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling 2932 56998 56896 11228 51421 1499 PMC6094490__F1 Toll-like receptor (TLR) signaling pathways 7096 7097 7099 10333 7100 929 4615 51284 7098 54106 29110 3661 3665 PMC6095619__F1 cGAS and STING: At the intersection of DNA and RNA virus-sensing networks 115004 29110 3661 PMC6097514__F1 Targetable cell survival mechanisms.Notes: Stimulation of the BCR and its co-receptor CD19 results in downstream signaling via the PI3K/AKT/mTOR pathway 930 2475 4067 6850 695 5336 613 PMC6098222__F2 Stimuli-induced TLR2- and NOD2- mediated signaling 7097 64127 4049 114609 4118 4615 10454 23118 7189 PMC6099536__F1 IL-33 signaling pathway 90865 3717 6761 51135 4615 85451 3654 59307 PMC6103702__F5 Representative cell cycle pathway between PCOS arrested and non-arrested 2-cell embryos 4087 4088 4089 5885 699 5111 993 1022 1017 6502 4485 8318 1869 4998 4999 23595 PMC6104123__F1 TGFB induces CD103 expression in tumor-specific T cells and participates in integrin bidirectional signaling 999 3611 7046 7048 PMC6106977__F1 MiR-30a significantly inhibits cell proliferation 2146 2139 6117 8660 92140 639 9690 5728 1499 891 10484 3417 860 6659 467 51514 7027 3837 PMC6106977__F2 MiR-30a significantly promotes cell apoptosis by regulating several relevant effectors 2146 6117 92140 3837 5728 PMC6109055__F6 Model: SIRT6 levels regulate resistance or sensitivity to MAPKi 51548 3485 7018 3480 PMC6110613__F2 Exploiting vita-PAMPs in vaccines 3603 3554 643 29851 920 51311 3553 PMC6110912__F1 Summary of roles of different E3 ligases on the development of cardiac hypertrophy 7187 7186 22954 4193 8139 7189 8557 6955 23118 2475 2308 PMC6110912__F2 Summary of roles of different DUBs on the development of cardiac hypertrophy 7375 11274 1540 9097 PMC6111862__F6 Model of ADAM‐17/EGFR signalling axis activation induced by deoxycholic acid in intestinal carcinogenesis 374 6868 1956 PMC6114477__F4 Inflammatory mediators in hepatocellular carcinoma 3627 2919 4313 5266 4087 4017 4325 4318 PMC6114982__F8 Palbociclib resistance and MAP kinase pathway inhibition 3845 1022 1017 1021 1019 2475 PMC6116003__F6 Wnt Signaling Cascade 324 1499 4040 4041 PMC6121366__F6 KEGG and BioCarta pathways of proteins encoded by genes related to cell cycle and ROS whose expression was altered in BS-24-1 cells after treatment with ethyl acetate extract of A 5885 4089 6502 9184 699 5111 1017 1022 472 545 355 637 581 836 842 64065 7249 5728 4193 6611 1874 1019 5640 4609 PMC6121429__F3 Insulin signaling 3667 8660 442338 PMC6121518__F1 Crosstalk between Hh signaling and autophagy based on current evidence 6608 6469 50846 3549 3845 2932 2475 2735 2736 207 240 664 2737 246 83939 81671 PMC6124166__F1 Schematic model demonstrating how PTH signaling leads to changes in SOST and RANKL expression in osteocytes 5741 23235 9759 10014 200186 4208 50964 7054 PMC6125039__F1 Human and yeast peroxisomal Beta-oxidation pathways 23600 5264 51 8309 26061 847 8443 84188 30 25913 8540 570 183 215 225 PMC6126176__F4 miRNA-risk genes-pathways regulation network 387914 401474 54014 138151 85397 79832 4082 355 5328 3842 27324 4360 80034 5495 5337 113835 219854 5728 10664 7586 27152 6631 9140 51199 2798 9788 9568 7565 2157 54532 114569 55251 7004 25875 4211 27069 5683 10269 175 5581 9575 54873 4049 29888 730755 9406 23011 1739 10981 56 28999 148418 4070 124491 64746 6395 253143 79694 9839 4133 55832 PMC6126377__F1 Oxygen sensing HIF prolyl hydroxylases modulate transcriptional and metabolic adaptive responses 468 5166 57761 2056 PMC6128695__F1 Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement 23373 266743 23237 3164 10682 627 4204 PMC6129574__F5 Metabolic pathway influenced by patulin and Protein interaction network of Kcr proteins 3418 5131 52 252843 8452 5538 1358 6500 6886 2242 10054 11231 6184 6185 7167 84174 1373 5230 1191 10486 7008 6161 6158 6168 5979 6156 55737 6122 6209 6169 4232 4691 6224 100009675 3036 84154 84294 80135 28987 6723 6133 2359 6159 6187 9241 10436 PMC6131212__F1 Activation mechanisms of the Hippo kinase signaling cascade 4485 60485 4771 9113 26524 PMC6131212__F7 Activation mechanisms of the Hippo kinase signaling cascade 60485 4485 7871 9113 26524 PMC6134143__F5 TNFR2-triggered, necrostatin-1-sensitive TNFR1 signaling 7124 7186 8737 841 11035 197259 3553 7185 PMC6137108__F3 Enriched KEGG dopaminergic synapse pathway following perinatal nicotine exposure in DA neurons 5578 5583 54331 2788 1813 777 128954 51764 5530 91860 810 207 2019 55970 PMC6137129__F8 Visualization of KEGG IL17 signaling pathway genes differentially perturbed (FDR < 0.05) in rat muscle infected with A 1878 6955 257397 7189 7186 10020 7054 8772 8178 3976 3934 66037 PMC6139224__F6 Diseases and functions analysis by integrated pathway analysis using 20 MeDEGs 1511 1519 719 1991 864 6688 5329 4055 2149 2534 55824 5551 4778 5583 1522 PMC6146607__F1 Lipogenesis and cholesterol synthesis pathways 47 38 31 2194 6319 355 79071 PMC6147049__F4 HER2 signaling pathway 2885 2475 4193 PMC6150077__F1 Diagram of gemcitabine metabolism and proposed mechanisms of gemcitabine resistance 207 6241 6240 PMC6150077__F2 Diagrams of the Hedgehog, Wnt, Notch pathways and their roles for gemcitabine resistance 6608 51684 2736 2737 2735 324 1499 PMC6151487__F5 Representative modules of ESCC-related metabolic network 3422 29958 27232 91734 2339 9517 10449 39 549 3032 3939 7263 5091 587 847 64902 593 51179 2875 54363 1629 443 5053 18 47 PMC6152498__F2 Targeting the cell cycle in breast cancer 2260 983 2475 4609 1021 1019 1017 7272 324 10733 PMC6153124__F1 Various published mechanisms of resistance to FMS-like tyrosine kinase 3 inhibitors 2322 283871 5888 PMC6154333__F2 Possible apoptotic pathway induced by photoactivated ZnPcSmix in monolayer cells 24 h post PDT 7124 330 841 637 9531 836 839 842 10017 581 578 7159 1647 PMC6154333__F3 Possible apoptotic pathway induced by photoactivated ZnPcSmix in MCTSs 24 h post PDT 664 581 2021 PMC6156463__F2 Metabolism of SAM 10419 2475 4507 PMC6156597__F14 Mapping of the DE genes exclusive to the oval morphotype on the SNARE interactions in vesicular transport pathway issued from the KEGG metabolic pathway– 100170220 6762 6761 8773 8674 6810 2054 6809 10228 8417 9482 8466 9342 10282 6855 53407 55850 6768 6845 8676 8675 412 PMC6160013__F8 Anti-oxidant activity of GPx3 mediating lung cancer suppression 2878 1950 1956 891 PMC6160310__F1 Hepatitis E Virus life cycle 6772 10379 3458 3665 9636 1977 71 203068 8661 3459 3455 1915 7251 1974 PMC6161739__F1 Canonical and non-canonical inflammasomes.Notes: Canonical inflammasomes assemble downstream of cytosolic PRRs including NLRP1, NLRP3, NLRC4, AIM2, and pyrin and control the activation of caspase-1 22861 114548 58484 9447 79792 834 3553 PMC6162436__F1 Hippo pathway upstream modulation 80014 122786 166824 4771 84962 83593 83937 11186 9770 4485 26524 9113 7003 8463 7004 7005 999 PMC6162501__F2 P53-ARF-MDM2/4 pathway (adapted from the p53 website) 3845 1869 4193 7157 4194 581 355 1026 1647 7508 2073 5371 7832 PMC6162868__F1 Signaling pathways of high-risk HPV oncogenes 595 1019 4193 PMC6163134__F2 Proposed signaling pathways in the development of hepatic portal hypertension 387 3717 6010 3131 PMC6164844__F2 Suggested mechanistic pathway of different flavonoids in the activation of non-shivering thermogenesis in BAT and WAT 23411 63976 7350 1374 PMC6164903__F3 Innate immune response to baculovirus infection in non-immune cells 115004 29110 3661 PMC6167501__F1 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy 2885 4763 2353 4609 3725 5697 PMC6169812__F1 New interactors of endothelial adherens junctions (AJs) 1003 7204 1499 2059 57493 8766 54922 83605 6714 6010 PMC6170174__F8 The role of Piezo1 and Gq/G11 proteins in endothelial response to different flow patterns 9780 1003 6714 5144 PMC6171904__F1 miR-451-AMPK-mTOR-cell cycle signaling pathway 2475 51719 7248 1032 1030 7249 999 PMC6175900__F2 Evolutionarily selected pathway (ESP) map 10847 7295 7916 79884 1387 871 80335 8239 79923 9412 9470 6873 5469 1915 23054 94234 2908 6294 26523 2316 4836 79759 5903 7322 26058 10075 5987 5594 860 9134 1601 604 699 5458 9667 7020 9662 86 1523 9329 675 9828 2042 147741 7272 28996 9924 9967 7547 8833 688 9757 3837 8085 9891 9739 57520 80144 9821 8496 6299 208 23426 50 7414 51366 4139 114790 7375 57492 2735 6794 5422 213 6597 3064 1499 1539 4647 9113 7273 4851 3265 10142 8291 91653 1272 84132 4297 5335 8729 4528 4771 9219 23113 3339 5788 5426 23418 2261 960 4780 6709 472 2064 7750 8218 5290 3667 3563 5604 9675 2185 338 22983 5787 5296 84966 2066 3845 3084 2887 545 5774 5579 4763 27333 673 51429 63892 3717 6638 5792 23352 5580 5159 170062 10382 5591 4036 3559 23218 6845 1832 5606 114928 10277 5295 6711 7297 8871 4745 5156 6279 2335 546 1756 284217 81786 84148 80352 9590 8295 6125 7317 1024 5728 64151 7402 2019 PMC6180204__F1 Negative effects of resveratrol on NFKB via several pathways in SCI 7099 114609 4615 8717 8737 3550 PMC6181033__F7 Proposed model for the role of ZmbZIP4 in maize root development and stress response 377 22931 4035 PMC6188467__F1 RNA-seq analysis revealed that LECs exhibit a highly perturbed cytokine–cytokine receptor pathway at 24 hours PCS 7124 3572 649024 2921 3977 3625 3791 2324 83729 268 2322 4049 3565 650 3578 56832 355 3952 3953 59067 53833 1896 10913 2689 5617 5618 7173 4352 5266 4050 53832 PMC6189293__F2 O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway cross-dysregulation in human chronic diseases 2475 3939 2932 3667 2308 572 4318 4313 64750 860 PMC6189458__F2 Map of autophagy induction 2475 8408 9706 9776 9821 60673 5594 5266 8536 814 30849 8678 1432 22863 5289 PMC6195654__F10 Hepatic fibrosis/hepatic stellate cell activation canonical pathway 4283 100187761 5155 1950 3565 1956 4089 4087 1435 59 4313 1277 3486 3458 183 6366 3082 5915 3587 1637 581 PMC6195682__F4 Cytokine/chemokine driven JAK-STAT pathway in transgenic spleen 5292 9180 2690 90427 2353 3977 929 1441 1643 3665 4599 207 716 6714 717 1520 3627 2633 2643 2634 3133 3574 1232 604 4067 5698 6891 6348 6354 729230 5817 3620 3566 7042 2868 720 3572 10379 6347 PMC6196657__F1 Expression and regulation of hepcidin in brain cells 57817 6774 3717 4615 7099 654 PMC6198057__F1 Scheme depicting the main upstream and downstream regulators of mTORC1 signaling pathway 7249 7248 23411 367 6009 596 2695 PMC6198132__F3 Hypothetical scheme for the unfolded protein response-induced signaling cascade in MANF-deficient beta cells 7873 83939 57761 8915 7186 22926 3550 7494 468 64326 PMC6205911__F1 Post-squalene cholesterol biosynthetic pathway and examples of malformation disorders associated with defects at specific steps 1718 1595 10682 1717 PMC6206931__F6 Overview of lipid remodeling in yeast during acid adaptation, where heavy arrows indicate enhanced biosynthesis 3398 5053 84249 25913 PMC6208316__F2 Analysis of pathways responsible for the expression of TGFB target genes 8740 7422 9173 969 51744 355 8807 7462 64750 57154 7189 4615 2885 1316 3656 3654 4087 4088 1263 5603 836 3398 4794 4602 8870 3725 4092 4069 PMC6210393__F7 MAPK signaling pathway from KEGG database 7975 4351 2002 2885 6722 5894 2316 7124 8717 355 1616 4149 4208 929 23118 51295 1950 4609 51701 PMC6210917__F7 Tsc3 regulates the balance between canonical and noncanonical SPLs by promoting l-alanine incorporation into the SPL de novo synthesis pathway 5004 5005 7054 PMC6213474__F1 Canonical and Non-Canonical Sonic hedgehog (SHH) signaling pathway in endothelial progenitor cells (EPCs) and endothelial cells (ECs) 6469 6608 5727 387 51684 4313 PMC6214130__F2 Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function 19 948 9619 1581 1593 2328 5465 PMC6214138__F2 Canonical FLT3 and mutant FLT3 signaling pathways 2322 5786 126669 2475 572 5524 4067 PMC6215617__F1 WNK pathway and major cancer-associated signaling pathways 6446 130497 4087 4088 PMC6216024__F1 Hedgehog signaling pathway 51684 374654 6608 PMC6217971__F3 Co-occurrence networks of diagnostic KOs involved in major energy and carbon fixation metabolic pathways in Llamara microbial mats from pond LLA9 6389 84365 4513 51166 6392 1353 1738 6657 637 6390 6391 5132 51071 100653365 3240 4514 1636 PMC6220063__F1 Eicosanoid biosynthesis and PGE2 signaling via EP receptors 4512 5226 759 PMC6225117__F1 Molecular mechanisms of (-)-epigallocatechingallate (EGCG) suppressing the proliferation of cervical cancer cells 1956 3479 2475 1017 PMC6225629__F4 Reconstructed metabolic pathways (KEGG) of S 2597 7086 5183 6120 22934 4018 95 PMC6233321__F1 Ceramide pools and their metabolic connection 10715 253782 91012 204219 29956 79603 6611 64781 PMC6233323__F1 Integration of Drosophila and Human Genetics to understand Notch signaling related diseases 285203 57534 1024 8650 PMC6234768__F6 Mechanistically distinct regulation of VEGF secretion in MDA-MB-231 TNBC and T47D (ER+/PR+/HER2-) cells 1958 6667 3976 5008 3091 PMC6237962__F3 Results of significant canonical pathways associated with ion-transport and the molecules involved 5350 6262 545 PMC6237962__F4 RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization 6714 1080 1390 PMC6240761__F1 Hypothalamic-pituitary-adrenal axis signaling 1392 2690 1956 3479 2638 7124 6347 729230 PMC6245347__F4 The miRNA-target genes involved in cancer signaling pathways 5728 355 113091 25 4609 7531 PMC6249229__F5 13C metabolic flux analysis and RNASeq explain the overflow metabolism 2023 3099 11113 100996949 5131 48 4118 6887 6886 4190 PMC6250284__F1 The nicotinamide adenine dinucleotide (NAD) synthesis pathway 93100 10135 203447 PMC6254932__F6 VHL-HIF-BNIP3 signaling pathway 7428 664 7039 1950 PMC6255705__F9 Schematic representation of metabolic reprogramming caused by the DAPAT mutation during diurnal cycle 2571 1431 728294 PMC6257835__F6 Involvement of circRNAs in the ErbB signaling pathway 1026 2002 815 1398 5604 2069 5599 6416 8503 5296 23533 2475 5294 10298 5062 5058 145957 5295 5578 10000 818 1956 1839 2064 2932 6777 4690 1950 10718 1399 5063 6655 56924 399694 53358 685 6464 5894 6199 868 5582 1027 374 3845 208 5594 5336 25 5291 817 9542 3084 6198 6654 8440 2549 27 5579 2066 5602 3725 2885 2065 7039 5290 5747 6776 867 673 6714 PMC6260860__F3 Different gene expression profiles in metabolic pathways of E 5805 2597 7086 6120 4524 5091 1431 1636 545 PMC6260925__F6 Senescence prevention by HO‐1 activation 260431 65018 8011 PMC6263010__F2 Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus 5727 4280 6469 2670 6657 1641 PMC6263441__F1 Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa 9126 5885 9985 23626 11144 4436 2956 4292 4438 4439 80198 PMC6265603__F3 Altered PI3K/Akt pathway during normal and insulin resistance 8473 10724 5728 PMC6269503__F1 Role of Hippo signaling in regulating immunity 4615 4485 3661 2919 9113 115004 PMC6269824__F1 Biosynthetic pathway of sialic acids and feasible implementations of artificial precursors 140838 54187 10020 PMC6271692__F5 Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules 3558 10135 7422 6351 6348 3605 6347 3592 3552 7124 3569 1236 1942 4843 5698 56475 2099 6772 5970 6097 4255 55922 7538 PMC6273515__F3 Bound sulfur activates the nuclear factor erythroid related factor 2 (Nrf2) system through a structural change of Kelch-like ECH-associated protein 1 (Keap1) and promotion of the AKT/phosphoinositide 3-kinase (PI3K) signaling pathway 1610 875 847 PMC6273696__F28 Apoptosis signaling pathway was regulated by vancomycin in HK-2 cells 355 7124 637 581 2021 4170 54205 56616 27429 317 57448 790 2620 6093 PMC6273696__F29 PI3K/Akt signaling pathway was regulated by vancomycin in HK-2 cells 2885 3611 5728 11140 7248 572 4193 7249 6009 79923 1499 595 1977 PMC6273696__F30 mTOR signaling pathway was regulated by vancomycin in HK-2 cells 3643 5163 7248 7249 5091 6009 2475 1975 6007 9776 1977 6194 1999 PMC6273696__F34 Remodeling of epithelial adherent junction signaling pathway was regulated by vancomycin in HK-2 cells 999 3082 324 4830 9146 5898 PMC6273696__F35 UPR signaling pathway was regulated by vancomycin in HK-2 cells 22937 22926 7186 7494 468 821 596 10808 267 6400 10956 7415 PMC6273696__F37 ERK-MAPK signaling pathway was regulated by vancomycin in HK-2 cells 2885 1398 6714 5829 1793 4342 369 7444 572 1977 4609 2002 4772 6722 PMC6274068__F1 Capsaicin mediates saliva secretion via transient receptor potential vanilloid subtype 1 (TRPV1) 7442 1365 362 PMC6275123__F1 Wnt/Beta-catenin pathway 324 999 4040 PMC6275123__F3 The IGF2 signaling pathway 3481 3480 5164 5163 2885 5728 4193 2932 572 2475 PMC6276090__F4 Signaling pathways in osteoclasts involving V-ATPases 1499 1436 7189 6009 4040 4041 PMC6279243__F5 Identification of Key Differentially Expressed MicroRNAs in Cancer Patients Through Pan-cancer Analysis 3632 2260 2264 10818 3667 5728 2885 5295 10000 4303 894 4846 PMC6281578__F8 LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA 57291 6256 2932 5290 PMC6287618__F1 Role of EGF Receptor Signaling on Morphogenesis of Eyelid and Meibomian Glands 7039 2255 1839 1956 51665 387 4214 PMC6291505__F1 The involvement of several TMEMs in tumor growth through the TGFB signaling pathway 25907 28978 27346 92162 2932 1499 999 7018 PMC6291828__F1 B cell receptor (BCR) signaling pathways 613 558 973 974 930 29760 4067 5728 695 6850 5336 2475 10892 8915 84433 PMC6295312__F1 Gene-level alterations in muscle-invasive bladder cancer in the context of curated pathways 5728 9817 8452 1956 2064 2065 2066 5156 2260 2263 2264 2261 3480 3815 8821 5979 6098 238 2322 4914 3717 207 5518 867 54206 25 6654 4763 5921 6794 7248 6009 5781 6016 253260 2475 57521 7048 7046 91 92 369 673 5894 4088 4087 5879 5594 5605 5604 4089 4193 4194 1029 472 4609 11197 6422 4613 4610 6197 54894 27121 22943 27123 27122 4041 84133 4149 23269 2932 8313 8312 1499 4084 4601 4335 324 139285 1030 1026 1027 6932 7089 7090 7091 7088 6934 6945 898 5925 595 894 896 22877 1869 1021 1019 8642 54798 2196 120114 79633 2195 9344 51347 57551 3714 92714 55294 8454 60485 6788 6789 4771 9113 23286 55534 8850 1387 27255 2033 10413 5784 23418 286204 1454 1453 92737 5664 9611 23013 5927 8463 92597 PMC6297758__F7 Involvement of c-myb and E2F1 in the expression and amplification of MYCN 4613 1869 26013 51053 PMC6298973__F8 Proposed TLR 2, 5, 8 signaling pathway 114609 3654 51135 7189 23118 10454 3665 4615 PMC6299603__F2 Adipocytokines mediate pancreatic cancer tumorigenesis by different signaling mechanisms 3717 6774 2475 23493 23411 4322 PMC6299603__F3 Altered gut microbiota is responsible for pancreatic cancer progression 929 2475 4615 PMC6301151__F8 Schematic graphic of the mechanism underlying chondrogenesis driven by PC nanofiber membranes 5091 9242 7124 4050 4322 7185 7412 1280 6662 176 PMC6305219__F1 Cdon, Boc, and Gas1 act as positive regulators of Shh signaling during optic vesicle formation 50937 91653 6469 2619 6608 PMC6305535__F5 Representation illustrating the interactions of Fusobacterium nucleatum in colorectal cancer 7099 7097 999 4615 1499 3553 PMC6305585__F7 APOBEC1-mediated RNA editing in metabolic disorders 348 85451 339 PMC6305747__F2 Pentraxins-expanded network of complement activation and regulation 1356 5806 1401 727 2271 718 PMC6309157__F2 Molecular pathways that play central roles in mounting an immune response 5163 207 208 PMC6309266__F3 Long (lncRNA) and short (miRNA) of it: TGFBeta-mediated Control of RNA-binding Proteins and non-coding RNAs 7040 7042 4087 7046 4088 4089 100885779 4092 4436 27250 PMC6311107__F4 Simplified model of the molecular pathways by which neratinib and valproate combine to kill cancer cells 5156 2066 2064 2065 2475 472 8408 83939 9776 9474 PMC6313651__F1 Gut Microbiota, Fusobacteria, and Colorectal Cancer 201633 1499 196 406991 PMC6314084__F6 Evidence of active A 54433 1896 4094 355 PMC6314914__F3 Proposed PD-1 & PD-L1/L2 intra-cellular signaling between T cells and/or macrophage/monocytes, among others (e.g 940 942 941 PMC6315103__F1 ProQ-dependent changes in Salmonella-infected HeLa cells 4137 5566 545 4351 6237 7846 8039 PMC6315509__F1 Notch and Wnt signaling pathways 4040 4041 2932 PMC6317254__F2 Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma 4535 6389 7350 4536 6390 7351 6391 7352 9481 4538 4716 6392 4541 4519 4710 4728 4713 4715 4705 4720 6834 4513 4537 4514 4724 4708 PMC6317954__F1 General molecular mechanisms of metformin on inhibiting cancer cell growth 3479 3480 2475 PMC6318317__F1 Wnt signaling pathways and the intervention targets of Wnt pathway inhibitors 4041 2932 324 387 6010 1499 4040 PMC6319272__F2 Schematic depicting the proposed hypothesis that resistance exercise-induced adaptations may require the Hippo pathway effectors YAP and TAZ 8491 9448 11184 5871 60485 4485 9113 26524 55233 92597 PMC6321366__F3 Schematic overview of RAS and PI3K pathway and their interconnection 5728 7249 7248 6009 4485 PMC6321704__F1 Simplified reference TLR signaling pathway projected onto putative homologs in Trichoplax sp 257397 9618 23118 3661 3662 PMC6321707__F1 Putative Celangulin V biosynthetic pathway in C 4598 10654 4597 3422 3652 PMC6321710__F9 Pathway visualization 2308 3630 3643 867 PMC6322655__F1 Immune responses of macrophages and dendritic cells regulated by mTOR signaling 3479 5163 5728 7249 7248 6009 PMC6323527__F2 Variety of factors control Tn cell survival and metabolic pathway engagement after T cell activation 718 23657 1374 6472 2729 5468 355 8505 PMC6323673__F7 Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line 1907 10616 7538 57571 PMC6324070__F3 The MAPK (ERK) signaling pathway in the KEGG pathway map (hsa04010) where the main path from growth factor to ERK kinase is marked in pink 1610 4351 2885 6722 4763 1956 1950 4254 3815 11124 595 PMC6327716__F6 The ubiquitylation of glycoprotein (GP) VI signalling pathway 695 6850 2534 5336 4067 6714 PMC6329517__F6 Impaired autophagic and mitochondrial functions are partially restored by ERT in Gaucher and Fabry diseases 2475 7942 7019 3916 PMC6329627__F2 Lymphocyte‐mediated chronic inflammatory responses 4397 64806 5226 90865 85480 PMC6330122__F3 Neurotoxicity of Anesthetics: Mechanisms and Meaning from Mouse Intervention Studies 3643 1956 2932 2475 PMC6331208__F1 Neuroprotective effects of DBS at the synapse 5864 627 836 7942 581 PMC6335266__F1 Simplified representation of the complement system, divided into pattern recognition molecules (PRMs), pathway specific and common components as well as inhibitors 4179 1604 966 718 717 7448 721 720 727 729 730 735 PMC6336527__F2 UV-induced cutaneous tanning response 4157 4286 5443 1638 7306 5091 PMC6337314__F2 TREM2 activation and downstream signaling 54209 102 6868 27040 6850 7305 PMC6338529__F1 VGF/BDNF/TrkB autoregulatory feedback loop stimulates synaptic plasticity changes in response to rapid-acting antidepressant treatment 627 29904 7425 3190 27161 PMC6341304__F1 Mitochondrial dysfunction and diabetic retinopathy 6648 5428 7019 PMC6345383__F2 PDA cells have a remarkable ability to adapt to nutrient fluctuations and targeted therapies 4199 4190 2805 2744 2806 PMC6347823__F7 A schematic model showing the effects of duodenal ghrelin on hepatic glucose fluxes and insulin signals 4922 3643 885 PMC6349306__F1 Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway 5163 208 6446 207 PMC6350112__F1 COMMD7 Regulates NFKB Signaling Pathway in Hepatocellular Carcinoma Stem-like Cells 51588 149951 150684 79923 3172 PMC6352191__F7 Proposed regulatory network involved in Keratinocytes of Type 2 Diabetes 1356 695 54106 5617 4600 9636 4940 4939 4599 51284 7054 PMC6354076__F2 Sirtuins and B lymphocytes 613 23410 23409 23411 51548 10113 2638 921 22933 PMC6354556__F1 Role of the biomarkers explored in the study on EGFR signaling 3082 1956 4340 64866 6714 558 3611 3717 5829 2932 6774 10413 1499 PMC6356085__F6 Network analysis identified RABEP2 as an important protein in inflammatory and signaling pathways implication in the development of inflammation and cancer 27159 27295 79874 1147 6160 2591 6124 6714 6611 201294 6152 2287 6727 58477 PMC6357482__F8 Schema of miR-205 regulated ZEB1, ZEB2, EMT pathway 6935 9839 999 PMC6358521__F2 Lessons learned from the study of human inborn errors of innate immunity 54106 7098 51311 51284 4615 57506 9636 51135 7189 3654 10379 3394 7187 11274 6772 6773 29110 3665 3661 5970 3454 7297 PMC6359026__F3 Estrogen signaling pathways in cancer 1839 8205 2885 6714 596 1956 PMC6359475__F1 Extrinsic and intrinsic pathways of apoptosis 8772 637 581 PMC6359975__F2 Acquired resistance mechanisms to CDK4/6 targeting 5163 673 1019 1017 6194 4193 572 PMC6360084__F8 Identification, expression, and phylogenetic analyses of terpenoid biosynthesis-related genes in secondary xylem of loblolly pine (Pinus taeda L.) based on transcriptome analyses 4598 10654 3652 4597 PMC6361568__F7 Cullin‐3 (CUL3) and KCTD10 regulate cell proliferation in SKBR‐3 cells 1950 5879 1956 388 8452 83892 PMC6361575__F3 Smad3 linker phosphorylation negatively regulates transforming growth factor‐B (TGF‐B)/Smad3 signaling 1950 3082 2932 4088 4089 1499 51176 6667 2303 PMC6365498__F8 IPKB analysis of relationships among upregulated genes on silk film topography 3714 5663 8650 4851 5518 1398 5581 2316 2872 2317 6774 113878 23493 PMC6366073__F5 Euglena gracilis has flexible and fault-tolerant mitochondrial metabolism 7523 2242 717 23479 174 PMC6368618__F8 Decidual RANKL/RANK interaction promotes the residence and polarization of TGFB1-producing regulatory GD T cells 941 942 50943 PMC6368966__F1 Proposed divergent role of Notch signaling in endothelial and smooth muscle cells 4854 659 4851 3611 857 PMC6369205__F11 Regulatory role of GRK2 in TLRs-mediated signaling pathways for iNOS expression in microglial cells 7099 156 54106 7098 6772 6774 3659 PMC6370039__F1 Relationship between NFKB and autophagy 7528 407029 9474 PMC6370039__F5 Relationship between the overexpression of YY1 and autophagy 5728 7528 355 999 9474 PMC6373340__F5 Insulin resistance mechanism and potential sites of vanadium activity 5728 2885 7248 1431 5091 85451 7249 2147 6009 4018 355 79071 5313 948 PMC6374012__F1 Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach 3716 7297 6773 6772 8651 7084 PMC6374178__F4 Possible neurochemical/molecular pathways for stress-induced synaptic remodeling in medial prefrontal cortex 627 2475 2638 PMC6376273__F2 The pathogen‐derived molecules employed to evade the intracellular DNA sensing pathway 9447 3428 115004 100187761 29110 3661 PMC6377292__F1 Transcriptional and epigenetic regulation of microglia in health and disease 4397 54209 861 6299 348 4208 9935 3394 8553 8190 1524 1436 5176 6518 64805 558 3665 4599 1512 56937 PMC6378284__F6 WWOX controls TGFB, Hyal-2, and Wnt signaling pathways that cross talks with the Hippo signaling 51741 154796 1856 4771 2932 4087 4088 4092 4089 4485 324 9113 26524 8692 6657 4609 2246 5054 7048 7046 PMC6381741__F2 Differential expression of A 497188 7353 100187907 22926 581 83939 823 468 PMC6383445__F2 Roles of PARPs in the immune response after pathogen invasion 5073 142 64761 54625 165631 54464 10146 PMC6386234__F1 Molecular pathways of cellular senescence 545 472 2475 4193 1019 1017 983 PMC6386826__F1 Signaling transduction of mTOR pathway 1029 4193 5728 7249 7248 2475 64223 253260 1977 6446 PMC6387042__F1 Mammalian or mechanistic target of rapamycin (mTOR) complexes and signaling pathway of mTORC1 and mTORC2 5728 9675 7249 6009 2887 64798 6774 1977 1999 1975 PMC6387281__F1 Schematic overview of the autophagy process and genetic and drug targets to inhibit specific aspects of autophagy 9474 9140 83734 64422 10533 9706 9776 PMC6390002__F2 Comparative analysis of genes in regeneration-related signaling pathways of regenerative animals 6926 3977 3976 6774 6657 2885 2247 79923 652 1852 4087 4088 4838 324 2932 1499 6929 9113 26524 4485 6608 PMC6390351__F8 Schematic representation of TLR and JAK-STAT pathways postulated in the slug I 3466 7187 4615 54472 9618 23118 7189 51295 PMC6391732__F3 Notch signaling pathway as seen in the KEGG database (hsa:04330) 8650 3280 388585 23385 PMC6391768__F7 Schematic illustration of vitamin D/VDR’s regulation on HIF-1A as well as IFNG and IL-1B in oral keratinocytes 7099 7428 7421 3458 3553 PMC6397983__F12 The insulin-like growth factor system role in PMSC differentiation into the skeletal muscle 3489 3481 3479 3667 2475 6657 5081 5077 4656 PMC6398892__F2 Regulation mechanism of ECM/integrin/EphA1‐mediated cell adhesion 100187761 2041 3611 387 PMC6399612__F9 Myogenin promoter‐associated lncRNA Myoparr is essential for myogenic differentiation 114004358 11201 10521 283120 PMC6401500__F2 Activation of NFKB in ITME 958 7189 8717 7187 7186 5971 472 6741 PMC6402888__F2 Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases 2167 355 7099 19 PMC6406361__F1 TNF-related apoptosis-inducing ligand (TRAIL)-induced signaling pathways 8772 637 842 7186 836 8737 11035 197259 10454 23118 257397 PMC6406581__F3 Mammalian target of rapamycin (mTOR) pathway 55615 64798 8408 9776 5468 PMC6407036__F3 Biomarkers in the Pathways in cancer 2669 5447 867 4118 8009 7010 7054 4086 324 387569 572 842 836 4436 4089 4437 847 581 51426 1950 2689 2475 367 107966124 4087 8213 PMC6407036__F4 MiRNAs involve in different types of cancers and colorectal cancer biomarkers 619501 324 5728 8626 1537 596 4325 9839 472 765 6659 399694 6395 2735 847 10253 54808 PMC6408937__F1 T cell activation induces cell surface expression of GLUT1 and amino acid transporters, facilitating uptake of glucose and glutamine 940 8473 10724 PMC6409413__F7 miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGFB Signaling 10716 4088 4087 4089 4739 4322 8728 7057 7422 7046 PMC6412134__F1 Targeting GBM CSC-mediated chemo/radio resistance by small molecule inhibitors 6469 3897 1956 102 6608 2735 1499 5884 472 9429 PMC6412963__F1 Overview of cholesterol trafficking in enterocytes 29881 3949 64241 64240 19 PMC6414445__F9 Rickettsia conorii and R 4190 47 5160 3030 1738 3032 6576 1431 10452 4200 3417 4191 50 56993 23788 2271 7419 1743 7417 2806 7416 5250 292 293 PMC6419612__F1 Metastatic progression in the bone 6387 8205 22943 4015 PMC6423797__F2 Regulation of immune EP expression by Tumour necrosis factor (TNF) signalling after exposure of IPEC-J2 cells to micro algae extracts in the absence and presence of ETEC 7124 1379 840 8772 771 836 1435 83737 355 3569 8717 4314 64127 197259 6401 4792 5743 843 PMC6428898__F3 Mec1/Rad53 pathway senses ongoing DNA replication to inhibit mitotic entry 4360 50964 5979 10450 10926 4827 100188784 7911 5493 5409 PMC6429226__F3 The effects of polyphenols on signaling pathways in prostate cancer 3082 1950 999 3479 367 2932 5728 6714 1499 324 7018 PMC6429457__F4 Upstream regulator analysis of the differential proteome of the spleen from 11-week Npc1−/− mice 1510 1509 10457 2990 714 8115 58533 4318 219972 PMC6433964__F2 Regulation of PD-L1 expression in response to DNA damage in cancer cells 115004 472 545 PMC6434430__F2 ERK signaling pathway was hyperactivated in the patient’s tumor tissue 466 27040 3815 4914 2885 5979 5156 5159 3845 780 5906 4609 1956 3725 2353 6722 572 2002 7535 1436 PMC6434684__F1 Sonic Hedgehog Pathway 6469 5727 6608 2735 51684 PMC6435474__F4 Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of ClockΔ19 mutant mice 7040 655 406983 7046 659 5187 894 332 9975 595 9575 1407 2736 406 9113 8864 4609 1408 9572 1739 8863 8312 7003 23513 324 7532 1454 5500 10297 5521 5499 5515 5518 PMC6436758__F7 Cellular response to small molecules that selectively stall protein synthesis by the ribosome 90441 10973 51008 84164 3692 10767 53918 26046 9147 PMC6437054__F1 Interaction map and annotation enrichment of the newly synthesized mazEF-related proteins 10845 6010 6957 PMC6437685__F2 HEV infection leads to the expression of IFN and other proinflammatory cytokines through activation of interferon regulatory factor 3 (IRF3) and nuclear factor kB (NFkB) pathways 6772 6773 29110 3661 10379 PMC6437734__F2 VPA induces M1-M2 polarization of macrophages in response to LPS 958 941 942 PMC6438741__F3 At the intersection of DNA damage and immune responses 3575 10113 581 6850 572 2308 29760 3662 5292 11040 121599 5897 472 PMC6438930__F2 Therapeutic targeting of glycolysis, lipid and redox metabolism in CSCs 948 355 2744 PMC6443324__F2 Modulatory mechanisms of TRAIL extrinsic signaling pathway by E3 ligases and deubiquitinases 83737 7186 79654 637 581 317 9101 9099 8772 8737 23608 54623 PMC6443331__F5 AMPK-dependent anticancer activities of honokiol in ovarian cancer cells 7249 7248 2475 4318 PMC6445151__F3 Differential network for the pathway “Signaling by NOTCH1” in the lateral compartment 84441 1387 9794 2033 7316 8850 4851 1840 7314 3714 3516 83737 22938 PMC6449645__F1 (A1) GPCRs induce GAq dependent c-Src activation at the plasma membrane and tyrosine phosphorylation of NEDD4-2, releasing NEDD4-2 auto-inhibition 717 6714 4734 23118 10454 PMC6450552__F2 Systematic illustration of PGRN-mediated signaling pathways 8788 1969 6774 4303 PMC6450717__F7 Loss of CHP1 rewires glycerolipid metabolism in proliferating cells 137964 5825 8443 11261 4018 5091 7038 PMC6458850__F6 The role of CXXC5 and molecular mechanism of KY19382 in longitudinal bone growth 1499 51523 2932 PMC6460507__F5 Notch and APP signalling pathways 351 102 8756 6868 PMC6461132__F3 Negative Regulation of PRR-induced signalling 6850 114548 8915 4843 PMC6461577__F8 Fludarabine Improves NDV-Mediated Oncolytic Viro-immunotherapyOn the one hand, the viral RNA activates the cytoplasmic RIG-I signaling pathway in the host cells to produce type I IFNs or other antiviral molecules 3620 57506 6774 3665 3661 6772 3454 PMC6462325__F4 The effects of Cordyceps militaris on the levels of the main molecules in the TLR4/NFKB pathway in CKD patients 3553 4513 7099 PMC6463920__F6 Microgravity regulates cell proliferation and cell cycle via the CD117-Ras/cAMP-CREB pathway 5604 983 5771 1843 1844 468 595 896 894 1870 PMC6465620__F1 M6A function in AML 791229 9589 4609 3276 25962 79872 56339 4602 596 57721 5728 10153 6667 6668 8667 64783 23091 PMC6466611__F6 Cyclin C-Cdk8/19/3 inhibit the Notch pathway by phosphorylating the Notch intracellular fragment (NICD) and promoting its degradation in leukemic T cells 892 1024 1018 23097 PMC6466823__F4 Main pathways and respective genes found in different treatments of ECs 998 928 2022 960 2247 2896 214 1743 4162 5970 10988 5806 26509 5770 4846 10544 5591 5578 3122 3105 3118 821 3106 4720 10577 3920 290 55970 2040 2783 966 2782 10970 6282 5880 1476 387 1499 10890 51552 8766 1500 PMC6468149__F1 The Hippo signaling pathway-YAP/TAZ in human endothelial cells 4485 60485 55233 9113 81532 558 27063 154796 51421 374 9510 7057 PMC6468845__F3 Reprogramming of lipid metabolism under hypoxia 4035 10825 2194 2170 2167 2173 6478 10555 1374 123 PMC6469615__F2 Proposed metabolic pathway for shea butter biosynthesis adapted from Argout et al 5091 4018 137964 PMC6469996__F6 Pathways regulated by NNMT and proposed working model of mechanisms of action of NNMT inhibition as it relates to muSC activation and metabolic state in aged muscle tissue 23411 10135 4837 203447 316 PMC6470689__F1 Proposed oncogenic mechanisms for Plk1 5347 10210 51512 56155 5728 4193 5978 23512 100124700 4609 619501 PMC6471604__F1 Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis 56667 143662 4151 1499 6774 3717 3082 1956 150365 581 7077 8313 595 4582 PMC6472684__F2 Signaling downstream of the IL-2 receptor (IL-2R): (a) Janus kinase-signal transducer and activator of transcription (JAK-STAT) signal transduction 3716 3718 6464 2885 3091 4609 8140 PMC6475113__F5 EZH2 and Foxm1 as likely upstream regulators of PRLR-dependent gene expression 5618 7153 10912 890 3303 1789 5168 1026 23512 2146 2305 1874 2313 4800 2623 3910 54971 5347 81037 1063 25827 10592 55723 81930 10733 6422 8078 10112 4609 9134 2099 11040 3161 23396 983 58494 3235 3205 135112 6288 5265 6862 810 354 7704 330 64881 2128 6689 5081 474 5156 10537 8178 22981 57190 7124 7867 51199 672 51726 4288 26030 5021 55631 4804 5728 1031 6745 10657 PMC6476910__F2 DAMPs exposure 22926 468 83939 9474 10533 3916 581 6093 8773 24145 PMC6478123__F2 Regulation of fatty acid oxidation, mevalonate pathway, and arachidonic acid metabolism by p53 240 23175 355 47 2593 53354 PMC6478125__F1 RUNX3 and p53 act independently and in concert to elicit their tumour suppressive function 545 472 864 6046 PMC6479730__F1 General representation of the signaling pathways involved in the antagonism of both ionotropic and metabotropic glutamate receptors in anti-cancer mediated effects 4090 4086 2475 PMC6480215__F1 Regulation of osteoblast proliferation and differentiation by transcription factors 860 121340 1499 3549 PMC6482429__F1 Molecular pathways targeted by the TCMs covered in this review are summarized 7124 355 7097 7099 4615 7186 8737 2475 11035 23411 23410 197259 3146 PMC6485244__F2 NFKB-BRD4 signaling in innate inflammation and remodeling 5970 3665 23476 3569 6615 PMC6487278__F4 Schematic model for Cbl-b in BCR- and CD40-mediated signaling pathways Activation of CD40-dependent signaling pathway is mediated primarily by several TNFR-associated factor (TRAF) protein family members including TRAF2, 3, 5, and 6 613 4067 6850 29760 5336 695 7189 7188 958 7187 7186 PMC6487791__F3 Therapeutic strategies targeting mutant p53 9958 4193 581 1026 545 472 983 7465 PMC6491677__F1 Metacore™ map showing the signaling context of the genes contained in the “Vascular endothelial cell damage in SLE” pathway 7422 7186 3082 100187761 10576 7124 7896 3146 6347 PMC6492170__F1 Schematic representation of iron metabolism in the yeast model 2242 759 80790 2922 PMC6493983__F1 Pathways to cellular senescence in eukaryotic cells 545 472 1021 1017 1019 1282 59 PMC6494926__F1 Granulin biogenesis, quality control at the ribosome during its synthesis, and molecular mechanism of FTLD associated with mutations in the signal peptide of the granulin precursor 2896 5660 4074 4035 PMC6497837__F1 Schematic showing mechanisms underlying morphine tolerance 7189 7442 114548 4760 3725 PMC6497892__F2 Comprehensive overview of the role of Clusterin on apoptosis-related events in cancer cells 7808 3479 472 367 PMC6498404__F4 High-affinity IgE is derived from the CD80+ pro-PC subset of IgG1 memory cells in mouse memory responses 5091 920 26137 2638 604 60468 27086 2308 PMC6500672__F5 Putative suppressive pathway of Pj-ME in displaying its anti-inflammatory response 7099 4615 6850 6714 6774 PMC6501765__F2 Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) 51738 796 5644 2696 4295 5367 7200 2691 2492 113091 5741 6955 183 4018 256933 1081 7253 4922 4829 6343 6344 7432 623 7434 8466 6755 6865 11255 10874 6863 PMC6501790__F2 Epigenetic control and the circadian clock: linking metabolism to neuronal responses 10135 23411 6774 4808 406 9575 PMC6503643__F2 HSVs modulate antiviral mechanisms related to cell death in non-immune cells 27040 83939 581 PMC6504559__F7 Schema of possible mechanisms of action of MyD88−/− donor T cells during aGVHD 4615 90865 920 PMC6506414__F14 N-Linked glycan (A) and the calnexin cycle (B) 80267 9695 56886 55741 PMC6506734__F1 Downstream signaling pathway of adiponectin 26060 5465 6667 PMC6506890__F4 Mevalonate Pathway 38 39 3157 3158 3156 4598 3422 91734 4553 2224 9453 PMC6507454__F5 Transcriptome analysis results of nuclear factor erythroid-2 related factor 2 knockdown 79003 79980 11219 2354 4616 8061 9451 23764 3727 7975 4985 5465 9612 1267 4849 5195 10616 5829 7534 1499 4762 119 401 11168 6455 2580 9397 5530 8092 831 1975 57621 8428 4782 51193 8301 10846 2802 79444 3553 1982 1791 5432 3172 1053 6613 118 9135 3606 PMC6510993__F8 Model of GQ folding within the actively extending telomerase complex 7015 1200 25913 PMC6511038__F3 Enrichment analysis of genes transcriptionally related to morphometric similarity 4923 3363 1910 5330 1816 4842 3709 4988 54331 4886 1268 5733 5173 1901 3350 1815 152 PMC6513185__F2 Flavonoids on the expression of MMP and ADAMTS in osteoarthritis 3717 6772 6773 PMC6513185__F4 Effects of flavonoids on signaling pathway of NLRP3 inflammasome activation 3553 7099 114548 6850 10628 PMC6513188__F8 Schematic diagram for the inhibitory mechanism of CYC116 in mast cell activation 6850 2534 27040 5335 PMC6513775__F4 Possible site of action of beta (B) asarone in apoptosis, cell proliferation and growth 993 581 1017 PMC6514907__F1 Enhancement of SUMOylation in glioblastoma contributes to alterations in multiple cellular processes leading to an increased malignant phenotype 10055 29843 8554 10401 1021 7341 PMC6515249__F1 TRAIL (TNF-related apoptosis-inducing ligand)-mediated signaling 596 581 637 PMC6515249__F3 Natural-product-mediated multi-step regulation of the TRAIL-driven pathway 8772 57559 581 637 PMC6515307__F1 Mechanisms contributing to regulation of tumor clearance by effector cells 3586 942 941 1493 324 3558 PMC6517498__F2 Model of canonical inflammasome activation involving regulation of autophagy induced by Ehrlichia 54106 3553 4615 PMC6517498__F3 Model of regulation of inflammasome activation by type I IFNs in Ehrlichia infection 3553 54106 4615 3454 3455 PMC6521546__F5 Superimposing mTOR signaling subgraphs from KEGG and WikiPathways 2475 79109 64223 253260 57521 9894 9675 64798 1978 207 1977 253314 1147 PMC6522317__F2 Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis 811 3717 4352 2313 PMC6528338__F5 An integrated gene interaction network built for genes related to wing dimorphism 6158 6141 56342 6155 9960 6124 11224 6731 6156 5728 9516 10480 6132 9904 4839 217 5163 2091 83743 10399 192286 117246 51332 PMC6528487__F1 Selected genomic alterations are indicated by an asterisk (*): fibroblast growth factor receptor (FGFR) pathway (FGF19, FGF4, FGF23, FGF3, and FGF6 amplifications) 2251 2248 9965 2249 8074 10818 2885 2549 2475 PMC6528915__F2 Overview for the regulatory mechanisms upstream and downstream of ZEB1‐AS1 in cancer progression 581 1017 220930 6935 999 6774 4313 4318 406985 648 PMC6529190__F10 Adiponectin-mediated signaling pathway in HSCs 51094 79602 26060 1789 5728 PMC6529540__F3 Omics analysis discovered high-confidence networks involved in AD 5295 1499 351 7316 8452 3326 PMC6530346__F5 Effect of chronic treatment with PDF and addition of AlaGln on individual pathways 6010 847 2548 3930 2243 2335 2922 183 57817 325 5340 197 7276 259 3569 350 4666 1401 2244 3240 7054 7018 1431 3273 4771 55937 1356 629 5054 7067 710 3929 2147 PMC6533522__F2 SUMOylation‐mediated signalling pathway of cardiac hypertrophy 7341 6613 3298 6612 PMC6533683__F5 Integrin signaling pathway regulated autophagy and EMT 3611 1956 1499 2475 999 PMC6533683__F6 WNTs signaling pathway regulated autophagy and EMT 1499 7481 7474 7291 PMC6533856__F1 Leptin metabolism pathway 6774 9021 181 5443 PMC6534050__F5 Proposed model relating canonical and non-canonical Wnt signaling with teneurin-3 expression 89780 7474 1499 2932 PMC6537015__F8 The proposed mechanism underlying TRPA1-mediated CMF transdifferentiation and cardiac fibrosis after MI injury 8989 7045 10631 59 PMC6537587__F1 Soluble amylin and pramlintide are capable of activating the endogenous AMYR which is responsible for recruiting adenylate cyclase 759 59341 790 PMC6538211__F2 Illustration of the WNK-SPAK/OSR1-CCCs cascade in nervous and non-nervous system diseases 65266 65125 718 PMC6539837__F1 Some common metabolic features of adult stem cells are essential for the maintenance of their quiescence, number, proliferation potential, and differentiation ability 847 6647 2876 6648 4211 2597 5164 5166 23788 25874 1356 7351 PMC6540369__F1 a Biosynthetic pathway of glycyrrhetinic acid constructed in S 3652 3398 8213 11161 PMC6540932__F6 Network view of infected dendritic cells 10392 7099 64127 7098 54941 6850 338557 9636 5879 5894 7316 409 10454 5971 6714 7249 4485 6009 2475 3586 8309 50616 6351 3606 3592 1440 3458 1977 1975 5467 22937 7097 100187907 PMC6545862__F1 A potential nuclear factorKB activation pathway obtained by RNA-sequencing analysis in canine diffuse large B-cell lymphomas 930 973 54106 6850 208 5336 29760 4615 84433 8915 2475 7189 23118 7128 8517 4792 5970 6714 4067 640 695 3550 PMC6548405__F7 CBX2 is required to stabilize the testis pathway by repressing Wnt signaling 51176 84733 6662 PMC6548783__F3 IL-6 production by blood leukocytes is altered in the RA-like PsoA patient in response to immune activators 940 3553 7124 7099 9447 64127 7186 7189 10758 114548 7188 PMC6548990__F3 TNFR2 signaling 7187 23118 7185 PMC6548990__F5 Type I interferons in the cytotoxic TLR-TNF signaling network 7098 7099 3454 3455 8737 4615 7297 3716 7187 23118 6773 5970 6772 10010 10379 11035 197259 3661 3659 7124 29110 PMC6554685__F9 Cell Cycle and TGF-beta-Signaling Pathway Regulated by the E2F Alteration in Breast CancerThe (A) cell cycle and (B) TGF-beta-signaling pathway regulated by the E2F alteration in breast cancer (cBioPortal) are shown 10274 5885 4087 4088 4089 4193 6502 991 9184 699 5111 1017 8318 999 1869 10926 25805 3458 8454 6500 7057 7046 1616 387 10468 4838 PMC6555088__F3 GSK-3 signalling in heart 3611 4087 4088 4089 324 4091 387 1499 4092 5163 1869 4609 PMC6555892__F1 MINA Workflow 9140 4283 1606 1956 2885 3587 3595 8809 26191 64135 6775 3592 3558 59067 3559 10019 5771 PMC6557283__F2 YAP/TAZ signaling and resistance to chemotherapy 1440 1435 1437 6374 3579 PMC6562438__F1 Schematic overview of pathways that are involved in desmoplasia in pancreatic cancer, including drugs and their targets 7424 7422 7423 2277 6608 960 2475 PMC6563119__F5 Dual functions of the cancer cell-intrinsic Hippo pathway in immune modulation 9113 26524 6374 2920 2919 6347 1435 3659 7003 8463 7004 7005 PMC6563219__F3 Pathway visualization using downregulated differentially-expressed unigenes in Axon guidance, Regulation of actin cytoskeleton and Adherens junction 6091 6092 324 387 2534 998 1630 6714 4690 1499 4089 2932 PMC6563219__F4 Pathway visualization using downregulated differentially-expressed unigenes in cAMP signaling, Focal adhesion, Calcium signaling, Hippo signaling in fly and Notch signaling 6010 2885 23513 1398 1499 2737 PMC6563445__F2 The proposed mechanisms of IRF5 activation 4615 51135 6850 3663 64127 7189 64170 3654 5763 208 7099 51284 51311 54106 100187761 PMC6563508__F5 Cytosolic recognition of foreign nucleic acids and activation of interferon stimulated genes (ISGs) 1283 3454 3455 7297 57506 6773 6772 29110 3665 9636 3661 10379 PMC6566080__F8 Hematopoietic cell lineage signaling pathway in the male and female groups 978 759 920 924 960 100133941 930 933 929 3562 947 945 7173 1040 23379 951 PMC6566080__F9 Cytokine-cytokine receptor interaction signaling pathway map in the male group 3552 7852 3569 6387 3553 3589 6364 3565 1235 5008 3596 10803 3976 149233 51561 1270 1236 3574 3575 958 959 85480 2921 729230 27190 55540 6351 6372 6348 1234 3627 2833 1230 7850 7173 4352 3558 1232 3600 7124 6366 3556 6352 PMC6567798__F1 LncRNAs regulate p53 signaling pathway through MDM2 472 1869 4193 55384 PMC6572052__F4 Hippo Signaling pathway with marked expression levels of deregulated genes 10207 154796 166824 3689 174 2246 3398 4811 6657 324 23513 10020 11081 374 PMC6582499__F8 Schematic diagram illustrate the potential mechanisms of VPA and gemcitabine on pancreatic cancer cells 2669 6774 648 PMC6582778__F7 Proposed model of F 3458 208 383 3586 PMC6584345__F3 STAT3 signaling pathway and its regulation by bioactive peptides 6774 2475 126669 PMC6584345__F4 TRAIL death receptor pathway and its regulation by bioactive peptides 8772 83483 150365 4170 PMC6585493__F2 Transcriptional changes of genes involved in fatty acid catabolism, MVA formation, and energy metabolism by ΔYPL062W, whose reactions mainly occur in the peroxisome (A), cytoplasm (B), and mitochondrion (C), respectively 100996949 5131 25913 3652 3422 192 PMC6586801__F2 Hypoxia signaling in human diseases and therapeutic targets 100 136 134 135 PMC6589740__F1 Diagram of the proteins and precursor/product sugars involved with guanosine diphosphate-fucose synthesis, Golgi transport and attachment of core fucose to N-linked glycoproteins 8790 55343 2530 2762 PMC6590390__F1 Wnt, Beta-catenin. and PCP signaling 1499 324 5879 387 3725 PMC6591387__F2 Inflammasome regulatory network 9209 2313 9208 5610 10013 57506 11128 26191 64135 64127 5771 79132 8767 22861 114548 1147 29108 834 10940 4210 8678 29110 3661 59082 3665 2309 8878 22933 5788 7297 3553 3603 PMC6592070__F1 CAMP/PKA pathway in S 51083 5997 55276 PMC6592070__F2 CAMP/PKA pathway in C 2695 55276 51083 PMC6592070__F3 Connections between the cAMP/PKA pathway and virulence-related functions in C 9541 3084 6098 PMC6592288__F5 Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications 4763 5728 6009 1019 PMC6593070__F7 Curcumin mediated inhibition of cell growth via inhibition of AKT signaling and activation of mitochondrial apoptotic pathway 5728 596 581 2308 331 735 718 54623 PMC6595721__F2 Major mechanisms regulated by SUMOs and SUMOylation in kidney disease 5763 5970 581 7428 4087 4088 4089 6497 PMC6599319__F1 Simplified schematic illustration of pathways for Wnt/Beta-catenin, ERK/MAPK and PI3K/Akt and PGE2-metabolism 324 2932 5163 717 9536 4512 PMC6599710__F2 Genomic correlates of response to immune checkpoint blockade 567 84206 3659 8651 6772 51588 5771 3716 3717 187 3459 3460 PMC6600376__F3 Major phenotypic responses in activated, myofibroblast-like cells (HSC/MFs) as well as, more generally, in hepatic MFs 7040 7076 7077 PMC6600422__F2 Leptin receptor signaling is mediated by JAK-STAT, PI3K-Akt, and SHP2-ERK pathway 3717 3667 8660 9021 2885 6774 PMC6600524__F1 Schematic representation of androgen deprivation therapy (ADT) or androgen receptor (AR) antagonist in mediating therapeutic resistance and neuroendocrine (NE) differentiation of prostate cancer (PCa) 367 6347 25803 140685 7045 5742 3976 PMC6601370__F10 KEGG pathways enriched by the differentially expressed mRNAs in the competing endogenous RNA network 6010 1610 790 27040 PMC6605322__F7 Scheme summarizing the protective effects of sevoflurane on lipopolysaccharide-induced inflammation and apoptosis by suppressing the activation of the miR-27a/TLR4/MyD88/NFKB signaling pathway 7099 4280 4615 PMC6605468__F5 Schematic model of morphogenic gradients controlling striatal development and involved in abnormal neurogenesis in Rarb−/− mice 2248 5915 5914 429 4211 1812 PMC6606008__F3 Wnt signaling pathway with and without ligand binding and APC mutations 324 847 7939 PMC6606799__F2 Temporal changes in the transcriptome related to the central metabolic pathway in a synchronized C 2203 5183 4118 PMC6607732__F1 STING pathway activation in DNA repair deficient breast cancer 1493 942 941 50943 115004 8205 29110 3661 3627 6352 920 3902 PMC6607964__F6 Snapshot of trastuzumab resistance pathway 2064 91526 3945 PMC6610297__F7 Metabolic pathway of glycerophospholipid, glycolysis, and TCA cycle under hypoxia stress 355 5091 4018 1040 283871 9162 3417 PMC6610925__F3 Hexosamine extended and salvage pathways 4351 10020 55577 2582 8473 10724 PMC6612304__F1 An integrative model of the roles of mitochondrial metabolism in liver cancer stem cells 596 3099 7157 79923 6657 2597 4609 100187761 960 PMC6614345__F1 Differentially expressed miRNAs in thyroid cancer tissues modulating the MAPK pathway 1956 100616132 2064 2885 6654 673 5894 PMC6614373__F2 NFKB signaling pathway 7097 7099 54106 7098 8717 114609 7186 7188 4615 51135 3654 3656 7189 23118 257397 PMC6615111__F3 Molecular regulators and signalling mechanisms involved in the activation of astrocytes 3976 1270 56963 10215 6774 2935 2670 PMC6617469__F4 Expressional change of genes for the central carbon metabolic network in Kmmig1 5897 2820 84129 130 4191 3418 PMC6617682__F1 The mechanism of exosomal miRNAs loading 54487 29102 27161 PMC6620386__F8 microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1 693198 2335 2475 PMC6623175__F9 Model proposed to explain why BDNF fails to regulate local translation in the hippocampus of Ts1Cje mice 627 5340 2534 1977 2475 1826 23237 3984 9455 PMC6625100__F7 Showing Possible effect of the mutation in leptin–leptin receptor signaling pathway 3717 2885 9021 6774 5979 4342 PMC6627600__F1 Interactions between RHOB and EGFR, Ras, PI3K/Akt/mTOR, MYC, and HDAC 7039 1950 1956 2885 5728 3065 10013 2475 388 4609 PMC6627624__F7 Scheme of the post squalene pathway for cholesterol biosynthesis 6608 91653 6476 PMC6627906__F1 Signaling pathways and receptors involved in uveal melanoma (UM) and cutaneous melanoma (CM) 3479 3082 6387 3480 7852 2776 2767 5728 673 2475 PMC6628296__F1 Canonical Wnt signaling pathway illustrating therapeutic intervention points targeted by Wnt modulators 64840 1499 8312 4040 4041 22943 PMC6631793__F1 Iatrogenic interference with the initiation of antifungal immunity 6850 10892 64170 8915 695 1431 3458 3577 4094 PMC6636296__F1 metabolic pathways in cancer cells 2475 4553 1499 PMC6636438__F2 Schematic model of ROS-activated signaling involved in the rapid modulation of NGB levels, its localization, and function on the redox balance outside mitochondria 58157 3162 2730 1728 PMC6636509__F8 Proposed model for the impact of targeted therapeutics, vemurafenib (PLX) and trametinib (TRA) on differentiated/pigmented phenotype of melanoma cells 6955 1638 4286 4157 PMC6636823__F1 Canonical Wnt signaling pathway 2932 324 4040 4041 PMC6637848__F9 L-proline-mediated differentiation of mESCs to EPL cells 2475 4553 83939 468 PMC6640647__F2 Simplified TGFB signaling pathways 4838 4092 387 2475 4609 1017 PMC6643028__F1 GPCR signaling 2475 6010 998 6469 1499 PMC6643872__F2 ETC and ATP synthase are required for normal eye development 4535 4536 4537 4538 4539 4540 4541 4719 4720 4722 4724 4725 4726 374291 4728 4694 4695 4697 4698 4700 4701 4702 4704 4705 4706 126328 55967 51079 4707 4708 4709 4710 4711 4712 4713 4714 4715 4716 54539 4718 4723 4729 6389 6390 6391 6392 4519 4512 4513 4514 1329 1345 1350 1352 1353 1355 10063 2271 PMC6644047__F1 Simplified TGFB signaling pathways 4838 4092 4087 387 4088 4089 2475 4609 1021 1019 1017 PMC6644836__F4 Partial diagram of the “Signaling by SCF-KIT” pathway showing the feedback loop that generates the “p-STAT dimers” complex annotated in Reactome 3717 3815 7409 5781 2885 PMC6646234__F10 MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling 3280 388585 7070 581 PMC6651563__F1 G protein-coupled receptor (GPCR) signaling 27185 6010 2932 PMC6658002__F2 TNFR1-mediated signaling pathways 197259 8717 7188 7186 8772 1540 PMC6658002__F3 Other stimuli leading to necroptosis 7124 7099 7098 6773 197259 8772 PMC6661007__F3 Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases 6774 114548 2919 3627 6387 PMC6662982__F8 In metabolic syndrome, hyperglycemia, and hyperlipidemia cause nutrient overinflux to kidney cells leading to increased celllular metabolism, which elevates intracelluar levels of citrate and ATP 7124 355 948 3156 PMC6664158__F1 Proposed molecular mechanisms of PAX3 in glioma pathogenesis and progression 2932 1499 2670 595 4316 5077 PMC6664200__F1 Diagrammatic representation of human hedgehog signaling pathway 6469 5727 6608 51684 2737 2736 374654 PMC6667871__F8 Schematic model depicting the mechanism of DEPDC1-induced HCC progression 1235 6364 55635 PMC6668486__F2 NK cell transduction pathways involved in primary immunodeficiencies 3600 3716 3717 6772 1794 5970 5971 6773 3434 3458 PMC6678355__F5 Unigenes involved in the Wnt signaling pathway: Red and green represent upregulated and downregulated genes, respectively 51701 9350 324 4089 4088 25805 50964 6500 8454 6477 387 23002 9475 5447 PMC6678606__F1 Stearoyl-CoA desaturase 1 (SCD1) as a molecular target for anticancer therapy 1499 216 1956 1950 595 5728 2932 PMC6678780__F4 Protein network analysis of the overexpressed genes in the TLR non-responsive patient cells 23358 55339 26249 25897 6477 84261 5116 10962 375248 64682 4636 400986 23412 648 22955 140465 4820 23265 171023 2146 3609 25925 51222 5311 55320 5928 9203 7593 50717 1642 4926 23522 6599 605 54014 9968 55023 196528 6602 29072 80205 9656 23020 57680 29086 59286 84733 PMC6681682__F2 Functional networks overrepresented in the list of DE mRNA in response to infection of bMDMs with Streptococcus agalactiae strain ST103 compared to uninfected controls 55207 114990 51083 9111 8991 30811 400 3578 6776 4071 9645 51561 401409 55303 9232 3398 9760 6692 6504 4601 57685 10261 93185 8890 25953 129049 1070 6102 26292 9094 9061 26523 192670 397 23530 23112 80173 3161 11064 80776 9859 22994 11117 10806 203228 115761 114793 5330 79598 340527 PMC6683209__F1 Cyclin D1-CDK4/6-RB pathway and crosstalk in breast cancer 7249 1021 1019 1017 2475 1956 PMC6685071__F2 Impact of oncogenic pathways on evasion of antitumour immune responses 1499 55509 4609 3627 324 6351 961 6352 90865 2920 7157 5728 PMC6685260__F5 Molecular characterization of subpathway signatures 5241 2773 2782 2793 11337 11345 847 1147 2268 5894 2932 PMC6689321__F3 Cross-talk between the CDK4/6 and mitogenic signaling pathways in cancer 2885 7248 7249 2932 6009 1021 1019 367 PMC6690202__F1 Main pathways of NFKB activation 958 8717 23118 257397 5966 5971 PMC6690396__F3 Histone methylation-dependent DDR mechanisms 29072 165918 2956 PMC6690952__F7 Schematic diagram depicting the mechanism by which suppressor of cytokine signaling 5 promotes or inhibits hepatocellular carcinoma cell metastasis via phosphoinositide-3 kinase/Akt/mammalian target of rapamycin pathway-mediated autophagy 619501 9655 2475 PMC6695833__F1 YAP1/Hippo and wild-type p53 pathways coordinately maintain genomic stability in response to stress 4485 4193 9113 26524 10413 7018 PMC6697794__F8 Schematic diagram represents that leptin signaling-dependent activation of mTORC2/Phllp1/Akt pathway abrogates lysosomal function and negatively regulates macrophage defense during S 3953 6774 23239 PMC6698381__F3 Pathways involved in sphingolipid metabolism 125981 340485 55331 7357 427 56624 8877 56848 57704 259230 166929 6609 6610 81537 8560 PMC6698416__F3 Challenges in deconstructing multicomponent cell responses triggered as a result of uncontrolled RES-exposure 9817 5728 1499 PMC6698547__F2 LMP-1 rescues Smads from Smurf1-mediated proteosomal degradation 57154 4090 4086 PMC6698587__F1 Regulating mechanisms of UCA1 in multiple human cancers 652995 27161 9839 6935 1385 596 57403 6659 999 6624 4316 3146 2260 1499 PMC6699409__F2 MTORC1 and MEK-ERK signaling pathways regulate eIF4F activity and assembly 27250 1975 23191 1977 PMC6700252__F3 Intrinsic intracellular signaling cascades of BDNF-TrkB and TrkB-A2a receptors 627 2885 5266 PMC6700476__F1 Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells 2475 79923 6657 652 6862 83881 PMC6703955__F1 Outlines of Hh signaling(A) In Drosophila, Ptc keeps Smo inactive, partly by promoting its internalization and degradation 6608 51684 374654 2737 PMC6707858__F1 Role of the Endolysosomal System in Parkinson’s disease 65018 120892 55737 54832 PMC6716297__F7 SUCO related genes involved in the cell cycle pathway 9126 1874 10274 5885 4089 4193 6502 699 9184 5111 993 1017 1022 990 8318 4661 999 1869 10926 23595 991 PMC6716664__F2 MicroRNA regulation in colorectal cancer tissue and serum 5966 7975 885 51701 4193 664 5728 3630 3643 472 1017 10365 673 PMC6716664__F3 MicroRNA regulation in colorectal cancer tissue and serum 8646 25805 3458 8454 7046 7049 1387 387 3624 10468 5308 4838 92 7124 4052 PMC6721055__F1 SUMO conjugation/deconjugation cycle 10055 7341 6613 6612 387082 1431 100874191 1674 PMC6721316__F1 Protein functional interactome network for differentially expressed proteins identified in Pancreatic ductal adenocarcinoma (PDAC) tissue; down-regulated proteins (A) and up-regulated proteins (B) 3107 5549 4060 2040 5660 5339 3074 3921 6902 11330 1674 10093 7086 8039 2593 367 6175 79026 348 27044 26136 PMC6721560__F4 The PI3K/Akt/mTOR signaling pathway 5728 2475 64223 64798 253260 5163 2932 7248 7249 6010 6009 143686 9776 1977 PMC6722227__F3 Immunopathology of Trichomoniasis (TV) 718 6590 920 7054 PMC6723309__F1 Adenovirus-directed innate immunity through nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) 7124 3579 3577 115004 7099 3661 1956 PMC6723600__F1 IL-38 signaling pathways 3554 59307 4615 PMC6723645__F1 Pathway inhibition by targeted agents and their effects on cell proliferation, apoptosis, metastasis and angiogenesis 2885 6654 3725 2353 4609 PMC6731444__F8 A scheme for DMF induced SOCS3/JAK1/STAT3 signaling pathway in HCC cells 9021 3716 6774 619501 7422 9474 PMC6733361__F1 The potential molecular pathways representing potential targets for treatment in patients with ACC, based on the results presented in the current review 3480 3481 3482 3667 5163 5728 7249 7248 1029 1019 1021 PMC6733437__F1 Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway 637 581 150365 8213 666 PMC6735501__F1 Initiating events in autophagy 8878 8408 9776 9821 60673 8678 30849 5289 10533 9140 83734 9474 55054 64422 PMC6741141__F5 Metabolic pathway of aerial and submerged mycelia in the liquid surface culture of Cordyceps militaris 5226 2597 5132 1355 130749 210 PMC6743293__F2 Molecular mechanisms of KLF15 in renal fibrosis and mesangial pathology 28999 1017 1869 PMC6744284__F6 Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the tubulointerstitium 2520 710 3717 115207 2475 3725 2353 128486 572 8743 3458 7157 7098 PMC6745489__F5 Rectal cancer sub-clones respond differentially to neoadjuvant therapy 6710 29894 7916 7919 51604 9584 7224 8733 6733 84665 1674 4703 51426 23345 324 65110 3646 28996 10459 10921 6431 7157 708 56477 8974 9869 10189 5728 613 4023 4149 4335 7222 3275 7273 56655 3064 PMC6747268__F4 Signaling pathways involved in the switch between proliferation and dormancy 2475 22926 6009 1019 10397 PMC6748047__F2 Protein pathway analysis using serum proteins present in healthy controls and/or AA patients 6403 4921 5154 64581 6449 10105 5590 6361 27302 22795 3082 56288 7057 2487 6402 22943 27121 152330 7006 100124696 7293 7292 83999 596 4353 PMC6751321__F9 Diagram of the signaling mechanism involved in the myocardial protection mediated by carvacrol 8989 162514 5728 5163 PMC6755131__F7 Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway 2358 5336 2002 PMC6756887__F8 Graphical abstract of the senescence pathway in Idh2-deficient conditions 3418 6098 1017 PMC6757314__F3 KEGG pathway analysis of the differentially expressed genes in head and neck squamous cell carcinoma 1289 1305 5646 7512 85301 477 1288 3381 6505 3909 1281 2335 1277 23439 1101 1282 169044 1301 1291 22798 1300 1284 3678 1303 3918 1278 1280 1294 1290 6696 1293 1287 284217 4312 7148 22801 8309 729359 10580 316 28965 4129 2327 2173 54575 4257 440503 1577 126 5468 9370 1571 127 364 5105 3158 1576 218 54576 PMC6759650__F4 Mechanistic network analysis predicts multiple affected signaling networks 2305 1026 6667 2100 3065 4605 8626 2099 7022 5914 2353 8202 2033 10499 6670 3725 1499 3485 1956 2308 PMC6761006__F1 Glucose metabolism via hexosamine biosynthesis pathway links amino acid, fatty acid and nucleotide metabolisms to regulate cell physiology and pathology via protein O-GlcNAcylation 2821 8473 10724 PMC6762062__F1 Inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis 4050 5226 4015 PMC6763548__F1 Scheme illustrating the actions of adiponectin/AdipoR agonist, AdipoRon, in the liver and the muscle 51094 79602 5465 84254 48 23411 7351 PMC6763609__F11 DEGs are potentially related to Alzheimer’s relevant pathways and functions 10842 4311 8854 8743 1404 2922 22943 4914 12 6323 9615 1748 5121 7064 PMC6763782__F3 Regulation of the main phases of the autophagic pathway by the C2‐WW‐HECT E3s 11059 10533 60673 8408 9776 7405 7316 PMC6764500__F3 Significant metabolic pathways, Ubiquitin‐mediated proteolysis pathway and Adherens junction and Wnt signaling pathway for regulated genes associated with IS‐SM when compared to IS‐NSM 6932 672 51176 4281 7014 892 1610 29071 314 2744 158 9197 51301 PMC6767051__F2 Cell cycle‐non specific mechanisms for the resistance to CDK4/6 inhibitors 2475 4087 4088 4089 5728 1021 1019 5163 1017 9839 6935 PMC6767293__F4 Effect of corilagin on the TGFB signaling pathway in ovarian cancer 4087 4193 5111 PMC6767532__F1 Cyclooxygenase (COX) pathway and prostaglandin E2 (PGE2) signaling 4512 5226 5228 PMC6769444__F5 Proteasome pathway mapping of altered genes in DLD-1-miR-21 cells 6184 5972 6120 116028 6102 23237 3458 51371 PMC6769685__F5 Apoptotic pathways triggered by inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors 6714 637 2475 2021 PMC6770188__F5 Our model of the BRAF mutation positive mitogen-activated protein kinase (MAPK) pathway signaling mechanisms 6654 2885 2549 4763 PMC6770301__F2 Regulation of EMT at different molecular levels: upregulation of the WNT pathway, PI3K/AKT pathway, and RAS/RAF/MEK/ERK/MAPK pathway and downregulation of the TGFB/Smad pathway lead to the activation of EMT through downregulation of E-cadherin 999 324 2932 1499 6657 6925 2303 79923 4089 6774 10397 5594 3553 333929 PMC6770909__F1 Redifferentiation of thyroid cancer 5979 7253 5728 9232 673 128869 2475 7270 7849 PMC6774191__F6 ERKI/II (MAPK) can serve as a convergence site for multiple extracellular signals known to induce plasticity in mature neurons 6714 2885 6654 PMC6775302__F9 Proposed signaling network of regulating the formation and development of seminal vesicle tumors in TRAMP mice 1950 1956 6774 891 595 2146 1021 1019 983 PMC6775706__F1 Cyclin D-CDK4/6-INK4-Rb pathway in breast cancer 595 1021 1019 1017 890 983 990 4998 PMC6775706__F2 Signaling pathways associated with tumorigenesis and combined treatments that alleviate drug resistance 1956 3667 2475 1019 595 1021 652 1017 PMC6776190__F7 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs 1499 324 4040 4041 PMC6776190__F9 Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs 4086 4089 3466 9978 4091 4092 8454 7057 6500 64750 57154 1874 4087 4088 7046 6667 PMC6776881__F1 Proposed working model of omega-3 PUFAs induced inhibitory effect on inflammation and autoimmunity 9021 6778 6775 2625 PMC6776918__F1 Mechanisms linking HPA axis dysregulation and AD 551 1392 351 2638 PMC6777507__F2 Activation of serotonin receptors (5-HT-R) initiates a signaling cascade that leads to the activation of extracellular signal-regulated kinases (ERK) 351 627 6722 PMC6781492__F3 PPI networks and GO and KEGG pathway analyses for the top two positively co-expressed hub modules of SNHG7 in thyroid cancer 6159 6134 6233 6229 6146 25873 6218 55272 10921 6143 56006 6122 6169 5518 6202 6193 6128 51116 8666 6191 6227 51069 6187 6130 11224 6135 6132 6207 6170 2091 6201 6203 23521 6136 6205 6228 6235 6152 27335 1937 6223 9349 6129 5966 9045 6206 6147 6155 6154 8664 4666 3646 6208 6230 6124 6164 6137 6181 2197 3921 6157 6156 6210 51154 6141 6167 6161 7178 8665 6217 6224 6158 1936 6188 6166 6160 4736 6189 6628 25949 57819 56259 24148 10907 51690 10421 6626 6635 5886 5439 6634 8175 5437 8896 27341 3178 6631 5434 56949 5435 29894 28987 2962 9277 7307 10450 8106 26121 9092 10465 54555 92856 25804 79897 3615 51264 63875 10607 55168 PMC6781771__F5 AKR1C1-3 are involved in a pathway with 44 unique interactors 7474 2512 50964 7037 25987 23657 10057 29948 5052 10058 8804 140809 2729 7086 4363 4199 22949 2730 7296 2936 2539 8626 1646 4257 2877 1645 8644 2821 57016 874 5226 218 7295 54578 128 7358 873 6888 54577 1244 131 1066 216 PMC6784827__F1 Schematic presentation of mechanotransduction and inflammasome signaling 6850 387 5586 5585 9447 114548 PMC6787451__F6 Effects of ASA in SK‐N‐SH (N) cells 5542 1017 1019 7054 PMC6787465__F1 Schematic outline of major Btk signalling cascades 7097 930 613 4118 695 4615 638 7098 6850 4067 3661 29760 5336 114548 7189 3603 PMC6787567__F2 Involvement of lncRNAs in monocyte/macrophage development and M1/M2 switch 91 7956 8685 3458 100316868 PMC6790333__F5 Cell motility in cancer invasion and metastasis: insights from simple model organisms 999 7124 6714 2353 474168 PMC6790574__F5 Inflammasome 114548 58484 4671 9447 22861 4049 8772 171389 79792 1283 PMC6790656__F3 Biological applications of light‐induced dimerization systems 1408 4827 717 10519 387 5879 PMC6791268__F2 Oncogenic activity of Bacteroides fragilis and Salmonella enterica 6774 6608 999 1499 2920 2919 6374 PMC6791856__F8 Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation 3146 847 114548 PMC6794807__F9 Five functional lncRNA-mRNA trans regulatory network 9557 6472 4848 440 59330 65057 388948 PMC6795908__F5 Protein-protein network analysis using the DE genes (log2 fold > 2 and < 2) in the transcriptomic profiles of the cows with PTB-associated lesions versus the control group 4050 3248 10026 93183 2069 6884 2353 1839 162417 5837 178 7139 6401 290 5739 1047 6678 124359 6555 34 4338 3939 60592 64105 10164 7365 345 8029 84920 132949 5737 1491 9370 338 PMC6796845__F2 Extrinsic and intrinsic apoptosis 7124 8743 356 596 581 578 598 1630 56616 54205 27429 317 8772 843 841 637 842 PMC6796858__F10 Cortical branched actin controls the G1/S transition 348110 10095 57175 10552 PMC6796923__F4 LSECtin-BTN3A3 axis promotes breast cancer stemness in vitro 79923 6657 8205 11119 10384 PMC6797170__F5 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach 3033 5901 1356 643418 558 107966124 PMC6797988__F6 Inhibitory effect of glycyrrhizin on ferroptosis during acute liver failure functions by promoting the Nrf2/HO-1/HMGB1 signaling pathway 7018 3146 2879 PMC6799822__F7 Signaling pathways contributing to mucus production 1956 6778 3280 6667 1179 4586 PMC6800172__F1 Chemical structures (Panel A) of decursin (D), decursinol angelate (DA) and decursinol (DOH), and likely metabolic pathway (Panel B) of D and DA based on rodent data and human studies in vitro and in vivo 1557 1576 8824 PMC6802183__F7 Model structure consists of HIF-1A signaling, tumor signaling, and ATP depletion modules 1950 1956 2885 4763 2922 5728 81693 55872 PMC6803543__F3 Ras signaling pathway shown as an interacting network 2668 2774 5900 7010 5979 613 27040 998 25759 53358 6010 5922 6850 7535 1399 2885 2534 3932 9610 5868 5728 1021 1019 1386 468 1385 10488 6464 22821 PMC6805914__F7 EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells 2050 6714 4609 83939 PMC6813369__F2 Proposed role of the immunogenic cell death in pemphigus foliaceus 920 140885 811 9451 961 114034 8178 PMC6813780__F2 Genomics of Apicomplexan Parasites 7431 51083 6957 PMC6814203__F1 STING pathway signaling and regulation 11277 284076 9654 3146 3148 9447 7019 9830 90933 81844 115004 10475 59343 29110 8408 3638 267 79594 79102 22954 6048 23650 79792 5167 29800 79065 6786 22937 7187 3661 3437 3428 PMC6814379__F1 Glucose metabolism, energy production, and its importance in DNA replication and epigenetic homeostasis 26227 5723 2638 PMC6814794__F9 KEGG pathway enrichment analysis of methylated regions– 7124 836 8772 771 355 178 3569 8717 2353 3725 94337 4323 3550 197259 6401 5743 7186 7187 83737 4703 PMC6815541__F1 Probable mechanisms of the effects produced by lncRNAs on SCI 9314 285194 7099 9865 7503 497258 6416 79867 100507246 347689 PMC6815639__F7 Pathview analysis of the NFKB signaling pathway 3932 27040 472 613 6850 638 8717 3929 114609 3603 4284 4803 958 4049 4050 91272 3492 759 PMC6820656__F5 Ovarian cancer pathway enriched by target genes of the identified miRNA biomarkers in IPA 1950 2492 1956 1855 6714 408 5728 4548 1019 4318 4313 4513 5925 2254 PMC6823288__F6 Significant KEGG pathways enrichment of DEGs 7273 187 1909 54541 1630 3624 316 467 29851 6401 1462 722 9973 100271696 PMC6823372__F3 KEGG pathways involved in the lipid methabolism of zebrafish enriched after MPs exposure 23627 1611 5548 84890 PMC6824625__F9 Hypothetical schematic model for a novel oncogenic mechanism of G0S2 999 4313 4318 50486 6714 3569 5163 10413 9113 1499 PMC6826333__F1 Network of Beta-elemene-target genes 7057 55902 4842 4128 2882 2593 7186 3586 3738 5139 79608 54363 130 2534 1312 23382 5032 219 2628 131 4099 1191 6622 26047 10891 3276 212 1152 3082 10768 220 1906 3091 955 858 1739 3792 10369 351 1571 57731 100506658 27286 183 8301 65018 405753 57502 409 4045 4208 154743 127 22829 1908 6387 84532 153090 2660 1740 288 2029 114757 6900 1158 1393 4356 6770 477 1080 9112 53905 50944 857 50801 4884 8854 5860 6247 1803 5604 11315 1259 8506 2780 81788 10052 57555 9110 5053 84433 100 57419 4314 22941 2237 348 9369 4654 10439 4781 51086 23373 51327 3750 5913 4669 948 6311 4284 3767 383 1785 1258 3739 5781 3776 3752 57471 400746 5469 2056 84245 1735 79800 388591 10324 3952 10243 5581 341 11079 10499 2876 95 443 3777 27102 343 3398 2778 8001 5468 776 1734 27342 1260 1733 610 167127 1261 51074 2690 9244 201134 6855 1371 338567 3751 3553 2796 4159 3745 8573 5741 1741 84913 9066 23557 1742 4914 4552 8724 1813 844 9094 2304 22986 8861 2743 3749 22933 1824 3623 57030 79971 382 9607 116461 112724 6262 3624 124 57829 1832 6665 6570 43 22871 120892 348980 80746 126 27232 6038 847 7784 3778 821 834 221955 4157 3938 57282 9992 7531 10021 6647 3757 375 27430 2073 476 747 5728 2203 23463 10400 6326 79784 632 9187 5081 2038 81832 3145 9379 1829 9312 9863 5021 3737 30819 358 6812 3263 9099 5318 1160 51150 4354 8417 210 2235 1392 6336 170302 2697 3766 9162 3746 5467 2067 4987 85445 654 4548 217 2741 4878 23236 3747 7143 129521 1788 4504 7054 134 3728 260425 898 125 1103 5566 339451 26053 3479 9693 10672 5921 9314 2768 2068 8772 5564 2572 5649 29978 2243 262 91703 4887 143425 4988 1017 2071 929 3717 2147 1141 718 7173 4524 177 2987 1812 53632 595 1019 1149 54790 79042 54822 5978 51422 355 5064 94030 85358 5315 8989 3270 7881 55800 5864 9414 23743 50506 3208 191 221 4143 3606 23114 127933 3249 5590 114907 6804 3736 1159 5020 3748 3784 347730 8514 4144 8566 5313 PMC6826333__F2 Network of pancreatic cancer-target genes 7124 3569 1401 4790 5728 3091 3146 1045 3934 3480 7421 2026 581 142 6648 3320 3565 5295 7040 672 3651 5979 4846 5604 6927 2475 3586 947 3375 5313 2321 5594 7132 7046 3099 2778 4914 7015 5468 2810 332 836 4803 4087 56998 4015 331 4609 9049 842 5266 5311 5888 2023 999 3133 4524 5265 207 3717 367 887 2246 3479 5315 6098 3484 3667 673 886 2305 354 240 2668 255324 3688 3486 6347 3265 6387 4306 8190 399 4088 3290 3481 3725 7852 8082 472 2944 7298 3791 6647 5663 324 1493 6344 5707 4363 1786 3642 11333 7375 4170 4316 5744 5329 1499 3458 2571 94025 1604 7018 5715 3553 4588 598 2064 5091 4851 3552 5328 948 7157 5925 5798 6833 4907 11076 5327 2925 4843 5068 4792 6751 2353 4585 4193 7422 5443 8000 4292 3077 6608 2922 983 1080 796 6774 3630 2263 3082 328 8558 3172 1356 51747 355 1869 51738 3815 5347 572 3880 6502 4593 5743 2247 132299 27257 6755 1633 2693 4221 6714 3159 8915 3732 2065 8737 3855 2260 4092 5156 10232 7431 5894 54474 578 2099 51761 117159 2735 4323 1028 1081 1352 7077 7039 3845 6662 356 1432 2272 7515 9377 6240 5111 4023 55811 6275 5241 5781 5967 4288 4486 1956 920 7471 1048 8842 1649 7075 1026 1958 7432 1027 387 9734 960 4089 3558 5159 6855 1019 596 6678 6014 3439 890 2264 5879 5747 6667 5644 1950 9429 174 4583 6794 3559 2641 627 8743 5243 3166 6369 11330 2645 2688 4684 2740 7057 4582 6514 664 1017 3557 3383 2150 7032 1806 685 10018 595 22915 6690 6469 5294 885 5290 841 3309 PMC6826908__F1 Canonical Wnt signaling pathway 55366 8549 54894 84133 324 PMC6826985__F5 Gene activities in the cytokine-cytokine receptor interaction pathway 7124 3624 5008 3791 6347 2324 6667 3558 3815 4049 4055 4050 355 1440 958 3952 3586 53832 3565 51083 2056 2057 1896 2689 3590 49 7422 3626 83729 3977 3976 1270 268 650 3560 3953 729230 3566 7216 4352 56832 146433 10913 PMC6826985__F6 Gene activities in the calcium signaling pathway 90550 5350 858 859 952 613 8862 PMC6827255__F1 DNA-driven cGAS-cGAMP-STING signaling mediates innate immune response 3466 115004 6773 6772 29110 3661 10379 PMC6828502__F1 Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol 7959 140805 1644 PMC6829248__F2 Summary of natural product regulation in proteostasis machinery 5925 2475 4193 PMC6829950__F7 Summary of SP600125 enhances C-2-induced cell death in bladder cancer cells through resisting JNK- SQSTM1/p62- Nrf2 mediated anti-apoptotic pathway and switching autophagy to apoptosis 9817 64422 9474 10533 PMC6832561__F3 MRNA-miRNA interactions associated with the vascular endothelial growth factor (VEGF) signaling pathway 6714 351 57136 842 572 4846 5743 5578 5579 8877 56848 PMC6834139__F2 ST2/IL-33 immune cells signaling pathway 90865 6761 3082 3603 4615 3654 3550 3479 7040 3458 PMC6838686__F2 Systemic Immune Dyshomeostasis Model and Pathways in Alzheimer’s Disease 2932 729230 5091 10400 1103 3569 3606 4803 627 348 PMC6839531__F11 Schematic showing the proposed dynamic changes in the localization of LHCGR, DENND1A.V2, and RAB5B in various cellular compartments 3973 5869 1583 1586 PMC6844227__F14 KEGG pathway annotations of the PI3K-Akt pathway in non-small cell lung cancer 2475 1977 6009 1975 7249 9846 3667 5879 6850 613 930 5728 11140 5934 572 6668 6256 4193 PMC6846243__F7 Control case interaction visualized on RPGeNet showing the connections between NRL, NR2E3 and CRX retinal transcription factors 100169750 2321 140738 15 8721 3190 5071 6010 8455 6096 4089 3479 3976 84922 8815 1406 8850 PMC6851521__F1 Molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism 728655 5728 442917 2475 154822 11257 128385369 6774 8213 100885779 154860 55384 406906 PMC6852473__F5 Comparison of central metabolic features of the Rifle comammox Nitrospira 847 619537 4841 PMC6854078__F8 Proposed schematic representation of the signaling pathways involved in the redox regulation of inflammasome activation in G6PD-deficient cells 6649 3553 7099 2539 114548 6647 PMC6854084__F6 Proposed model for apoptosis suppression via R-Ras pathway by RasGRP2 3099 10235 581 PMC6856370__F9 Model of cross-talk between D2R and Wnt/Beta-catenin pathways, and Wnt3a transcriptional regulation 89780 4040 4041 324 2932 PMC6857441__F3 Schematic overview of androgen biosynthesis 3284 6715 6822 9060 2232 1584 1646 100187761 3290 3291 3294 1586 5447 8644 PMC6858840__F1 NAD+ biosynthetic and degradative enzymes 93100 203447 10135 23475 130013 952 23098 PMC6859786__F1 NLR-dependent regulation of MHC class I antigen presentation 114548 3553 10392 64127 6890 84166 567 7097 PMC6861325__F4 Pathway analysis network of 131 preliminary potential genes 2252 154 6358 3082 1950 3084 5729 85480 554 56920 3953 5063 3481 5618 56477 374 4804 2690 3815 6366 3952 1511 10451 9353 7048 10125 3479 223117 1215 2246 1910 80310 2261 10000 7068 799 9723 5156 32 652 50604 4311 5733 2247 627 10371 6869 1901 2908 5021 3977 658 4638 9370 PMC6862031__F5 Summary of altered metabolic pathways and regulatory mechanism of rFIP-nha against A549 cells 2539 57103 7249 9997 2475 2597 27165 5728 PMC6863034__F4 (A–C) The most significance predictive genes for renal ischemia-reperfusion injury (IRI) in the rat model 2919 6774 2316 4609 960 4314 3678 3675 7057 338339 3479 3684 101 4015 3655 5912 929 6347 PMC6864306__F5 Relevant signaling pathways deregulated in glioblastoma: receptor tyrosine kinase/PI3K/PTEN/AKT/mTOR pathway is shown in blue, CDKN2A/CDK4/6/ retinoblastoma is shown in green and p53/MDM2/p14ARF signaling pathway is shown in red 1956 5266 5728 2475 9215 1021 1019 1029 1030 4193 PMC6873994__F4 Predicted potential targets to combine with MAPK/ERK inhibition, using graph analytics 27040 203068 9055 6010 5436 64223 5447 5518 PMC6874216__F1 The biosynthetic pathway of ubiquinone (Q) in E 3652 27235 51004 51805 84274 10229 PMC6874469__F5 ERB/Ptgds signalling pathway imbalance disrupting renal lipid metabolism and continues influencing ‘hypothalamus-uterus-kidney axis’ (HUK axis) function 140805 5730 5226 259 PMC6874786__F1 PI3K/AKT/mTOR pathway in AML 5728 3569 6774 9474 10533 581 9140 PMC6875034__F6 STRING analysis of integrin signaling pathways and response to wound healing pathways 948 2317 2191 81 3685 966 2316 6279 5159 3690 928 5547 7414 1956 10627 4627 5315 308 5270 26509 2934 302 5025 30846 3315 1292 1293 PMC6875424__F8 Possible mechanisms of the effects of methane against APAP-induced hepatic injury 9817 351 1728 6651 PMC6877688__F3 KEGG pathway enrichment analysis of photosynthesis related genes in S6, S72, and R (control) groups 5091 6651 23481 66037 PMC6877688__F4 The endocytosis pathway 382 3949 273 832 84313 79643 100170220 6651 30844 8027 PMC6879499__F3 Construction of pathway map and PPI interaction map 2885 3667 5371 4763 5728 5906 5478 7249 7248 6009 10645 64798 253260 8408 1382 2033 4193 1387 10135 8505 142 9817 55811 51548 10397 5142 4792 3091 8321 23175 7157 27250 5468 23411 5879 1027 2309 2932 5518 6195 6720 10891 664 5594 3643 5499 92335 1856 54541 1973 5731 673 5290 5170 54583 2475 387 5829 57521 7534 6262 5737 1977 1975 23236 29904 1978 84335 64223 79109 9821 10411 55615 9776 23770 PMC6879841__F6 Pathway diagram of glycolysis, pentose phosphate pathway (PPP), and tricarboxylic acid (TCA) cycle highlighting metabolites that differed between control (CON) and intrauterine growth restriction (IUGR) fetal skeletal muscle and plasma 586 5213 5315 3939 PMC6881718__F6 Cellular context of TLR5 engagement by UPEC FliC in the bladder leading to early IL-10 induction 7096 7097 5879 54472 4615 114609 10333 841 8772 3929 929 10454 51135 23118 7099 7189 3654 7100 958 3663 941 942 3665 1513 54106 29110 7187 7098 3661 6772 51284 PMC6882007__F1 Hh signaling pathway transduction 51684 374654 6608 PMC6882982__F5 PI3K-Akt signaling pathway changed in FSH-positive relative to negative NFPAs 2475 1977 6009 7249 5879 613 6850 930 5934 5728 84188 572 5266 150365 6256 4703 4193 PMC6885271__F5 Proposed schematic diagram of LPS-induced ROS-mediated neuroinflammation, neurodegeneration, and memory deficits via dysregulation of the JNK/NFKB/Akt signaling pathway 2670 3553 2932 6616 PMC6885792__F2 The role of MYOF in membrane trafficking 1956 26509 857 7422 PMC6886211__F8 PLNet2: LocPL pathway reconstructions (first 100 paths) 3558 3716 4067 6850 3717 6464 5894 2534 5781 7297 2268 1956 3953 3480 9146 2057 996 867 2263 25 367 3815 351 9322 6714 5747 2309 9111 6774 1386 2908 3718 695 83737 PMC6886244__F1 Scheme of the N-linked glycosylation pathway 29926 4351 5373 29925 5238 85365 79868 55768 29880 2762 8790 2592 10020 54187 140838 55907 790 2582 7360 79087 55329 22845 440138 PMC6887790__F4 Biochemical pathway in neutrophils showing the signaling cascade and the effects related to DAG and PA activation 3576 3577 3579 100187907 PMC6888083__F6 Mutual regulatory mechanisms among lncRNAs and miRNAs 100507246 6935 607 9965 1875 399959 22943 84133 6047 10297 PMC6888337__F11 Canonical pathway explaining the NASH progression from steatosis to hepatocellular carcinoma 2194 6319 7436 9415 5346 123 8660 6610 7534 7533 80339 3992 619501 351 PMC6888566__F1 Wnt signal transduction 4040 4041 54894 84133 4038 8549 2932 387 324 1499 PMC6888741__F2 DUB family members 7375 7874 9099 9098 7398 8078 1540 8287 9097 9101 8237 9958 8239 23032 10868 10600 11274 83844 8314 PMC6889474__F3 mTOR Signaling Pathway 5728 6446 5163 7248 7249 6009 10445 1977 1975 29904 PMC6890838__F2 Defective proteasomes in CANDLE/PRAAS subjects provoke ER stress and trigger the so-called unfolded protein response (UPR) which is associated with inflammation 83939 468 57506 3661 29110 22926 PMC6890838__F3 Mutant proteasomes from CANDLE/PRAAS subjects have a potential pro-inflammatory potential due to the negative impact they exert on mTORC1 64798 83939 468 83667 3661 29110 22926 PMC6891142__F4 The suppressive effects of Crabp1 in adipogenesis and adipocyte hypertrophy 1381 1499 1050 3480 3479 1051 8660 3667 PMC6891441__F1 Scheme of Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) function in the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway 115004 5167 29110 3661 201626 PMC6891791__F6 Immune system pathways in KEGG pathway analysis 7124 6955 7054 8000 8772 6886 836 355 4099 PMC6893739__F2 Merlin signaling 2475 960 4485 5879 9113 26524 5058 PMC6894428__F3 Simplified model of the molecular evolution of each colorectal cancer subtype 1045 324 673 3845 4292 PMC6895177__F8 Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors 22926 114548 10628 3553 3146 PMC6896717__F8 The schematic model of the process of regulating Akt/mTOR signaling by NL3 9863 5728 7248 7249 6009 PMC6896744__F1 Schematic overview of the WNT signaling pathway 4040 4041 324 1499 4314 4316 102 7074 PMC6897284__F3 Epigenetic regulation of miR-126 by metabolic changes in malignant mesothelioma 3479 3667 23411 47 142 PMC6902872__F1 Pathway to chronic rapamycin therapy in prostate cancerModel: Chronic mTORC1 inhibition delays of PCa progression from active surveillance 2475 1977 1938 PMC6904269__F3 Schematic depiction of downstream mediators of the IL-36 signaling pathway 27179 27177 4615 PMC6904873__F6 PGP-mediated metabolite repair maintains flux through glycolysis and the pentose phosphate pathway 283871 2597 2739 PMC6905007__F2 LRF/ZBTB7A’s silencing compromises Warburg effect and induces apoptosis in cancer cells 5214 5315 57103 51341 9997 596 355 PMC6906418__F2 Intracellular sensing of viral genomes and viral evasion 8638 59343 9654 81844 9830 10475 115004 284076 57337 10146 91445 90933 85364 8841 3661 3665 PMC6906582__F4 Viral RNA sensing proteins and their downstream signaling 4940 6041 3665 3661 1998 PMC6908425__F2 Deletion of fumarases leads to changes in carbon fluxes and amounts of metabolic enzymes 4118 11113 101448070 22934 6120 6391 PMC6908425__F4 Deletion of glycogen synthase in a ΔfumABC strain restores carbon fluxes without changes in amounts of metabolic enzymes 101448070 4118 11113 22934 6120 6392 6391 5966 PMC6909953__F2 E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes 22937 22926 7186 10682 7494 468 821 811 596 10808 267 7415 PMC6912516__F2 Schematic representation of main ACVR1 signal transduction 659 92 93 90 4090 4086 6010 PMC6913448__F1 Structures of CLEC-2 and podoplanin 27040 695 6714 6850 PMC6918475__F1 Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs 25801 1581 1582 8205 8213 PMC6920345__F3 The impact of oncogenic RAS on redox balance and implications for cancer development 2181 2805 3725 468 4609 4118 3162 2729 2678 PMC6923785__F1 Mechanisms of resistance to PI3K inhibitors in estrogen receptor (ER)-positive breast cancer and current and future drug combination strategies involving PI3K inhibitors 1956 5728 2475 367 1021 1019 PMC6925860__F8 The schematic diagram depicts the mechanism of CPP-induced enhancement of sensitivity to TRAIL in ESCC cells 50943 8772 340451 1499 PMC6927934__F6 The cell cycle metaphase checkpoint pathway 324 3619 79003 991 25936 11243 79980 1059 64946 1063 25859 5347 983 8556 11186 1017 993 1431 6502 990 PMC6928850__F2 Testicular and ovotesticular differentiation in XX foetuses 6736 7490 7536 668 54361 6662 284654 6658 6663 2254 1761 268 269 367 PMC6928971__F2 Overview of hedgehog signaling pathway 6469 50846 3549 6608 PMC6936254__F2 PPI network of DEGs 56624 10117 4086 1917 3122 6490 3728 85455 8605 920 53833 9388 7280 7035 22915 167838 113612 2840 5649 2243 1437 4137 4192 8862 5740 10763 4162 947 5142 3791 3213 51378 633 50507 4319 9249 405 23462 4688 440 3714 9715 55876 3777 79094 3106 3750 55303 773 57126 84628 PMC6938454__F1 Lab Review: Molecular Dissection of The Signal Transduction Pathways Associated with PTEN Deletion-Induced Optic Nerve Regeneration 5728 5163 7249 7248 2932 PMC6938687__F2 The RTK-PI3K-AKT-mTOR signaling pathway 3479 3480 207 10000 894 6009 4609 9681 5266 51256 10641 8131 64798 PMC6938958__F8 Identification of Regulatory Modules That Stratify Lupus Disease Mechanism through Integrating Multi-Omics Data 1997 3717 8651 7297 6772 10379 6773 51191 9636 24138 1027 1874 4609 1875 4149 4335 5890 641 5685 5686 5888 5690 5696 5698 7018 PMC6939855__F1 Mechanisms of endocrine therapy resistance in ER+ breast cancer and treatment strategy 5266 4763 780 4292 5378 5395 252969 2099 472 1019 PMC6940409__F2 Photic- and non-photic-responsive MAPK signaling pathways in the brain 100379198 367 9575 PMC6940594__F4 ILK Signalling pathway generated using IPA 7124 5829 7414 4666 51176 2335 3875 7431 650 4318 4513 847 PMC6940991__F2 Mutant p53 gain of function (GOF) in metabolism and invasion 901 387 5159 891 595 6774 PMC6943888__F1 Regulation of D-secretase in neurodegenerative diseases 627 6733 6418 4129 351 6772 23621 5641 PMC6944231__F5 Presynaptic proteins that were altered in AD 27445 1213 440279 6844 4905 8775 2534 PMC6945546__F1 Mutated genes in HHT encode members of the BMP9/BMP10 signaling pathway 27302 2022 659 140805 PMC6945546__F3 Future treatments for HHT 27302 285 2022 6714 4090 4086 4093 5728 PMC6946658__F1 Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy 196743 262 6520 6611 54498 PMC6947155__F1 Schematic representation summarizing the main extrinsic (cell–cell contact and growth factors) signals that regulate the Hippo-YAP (Yes-associated protein) pathway 1956 5163 4485 4018 9113 26524 PMC6947155__F2 Hippo Pathway and YAP Signaling Alterations in Squamous Cancer of the Head and Neck 1956 2195 5163 4485 9113 26524 PMC6948307__F5 Schematic diagram of IL-1B signaling pathway in MSC adhesion to HUVECs 9242 3603 3383 PMC6948367__F1 Homologous recombination repair pathway (adapted from De Picciotto et al.) 3014 9025 9656 672 10111 4361 83990 545 472 79728 675 5888 5893 PMC6948367__F3 Alternative STING pathway activation 472 7189 10454 23118 3569 3659 3661 920 PMC6950657__F1 Mechanisms underlying the life-extending and tumor-inhibiting effects of calorie restriction in mammals 4852 3479 3480 2475 PMC6952937__F1 Two different NFKB signaling pathways 7124 3553 4050 5971 PMC6953055__F2 Dysregulated miRNA in the WNT/Beta-catenin liver cancer pathway 7227 27250 6935 324 1499 PMC6953055__F3 Dysregulated miRNA in the TP53 liver cancer pathway 355 841 581 1021 1019 637 842 836 PMC6953055__F4 Dysregulated miRNAs in the JAK/STAT liver cancer pathway 9021 10682 2475 4609 3572 PMC6953124__F9 Proposed anti-tumor mechanism of rubioncolin C 7186 4615 2475 7189 23118 10454 PMC6953314__F3 Intracellular signaling pathways of CAP, SNS, and HPA axis for anti-inflammatory responses 51284 7099 4615 51135 3717 3656 7189 6774 26291 PMC6954688__F8 Activation of the NMRK2 path to NAD+ synthesis as an adaptive energy sparing mechanism in the failing heart 10135 27231 5465 PMC6955653__F3 Role of lncRNAs and circRNAs in osteosarcoma 23642 6093 10488 10011 406990 PMC6957369__F3 Core analysis of genes differentially regulated by SP-D nitrosylation 356 7412 3559 6364 6403 355 4319 1647 6401 4316 4843 2920 5743 3659 959 3552 4615 3553 7124 PMC6959064__F2 Calreticulin-mediated LMP1 signaling network that promotes EMT in NP69 cells 3688 205 3880 2923 811 5603 7431 5684 3065 2908 5327 1936 3313 1431 3856 302 3106 51547 8767 1080 836 6667 203068 8450 3875 6742 5935 4000 1832 3852 1674 PMC6960179__F5 Molecular evidence of inflammatory response and resolution of inflammation during MAP infection 7099 7186 8717 79155 11213 3656 7189 7185 64127 9021 10318 58484 6774 602 9314 4843 6778 9966 5154 4282 5155 PMC6961549__F1 Crosstalk between hypoxia and the unfolded protein response (UPR) pathways 6478 7428 2475 22926 7494 468 8678 3091 5209 5163 PMC6963149__F2 Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development 1610 126669 79629 5728 2475 4193 1956 PMC6964830__F8 Functional network of proteins in stage 3 breast cancer samples 11328 60681 3671 55233 261734 23286 PMC6965651__F8 ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD 23608 8772 331 836 PMC6966539__F2 p53 control of cellular metabolism 57103 2539 2147 5164 9997 PMC6966539__F3 Dual effect of p53 on autophagy 65018 8408 10533 2475 PMC6966572__F2 PARP inhibitors in combination with other therapeutics 1236 3627 4283 324 3661 29110 PMC6966687__F3 Networks presenting the functional protein-protein interactions of the (A) 97 down- and (C) 67 upregulated proteins related to the GO term “protein phosphorylation” (GO:0006468) 238 6608 26524 253260 3991 208 2475 4058 9833 54861 6790 10922 27 7010 7006 100124696 23178 84930 5062 4593 139728 PMC6972667__F4 Linking the protein C pathway with EPCR‐ and ICAM‐1‐binding IEs in cerebral malaria 324 7450 3383 4318 PMC6978272__F8 How CSF induced accumulation of endosomes, autophagosomes, and lysosomes, which led to increased intracellular AB accumulation 351 7405 3375 3916 PMC6980728__F3 NAD+ biosynthetic pathways and model for SARM1-mediated degeneration 4837 93100 203447 10135 23098 23057 64802 349565 952 PMC6981417__F6 Differential ganglioside metabolism pathways between Hs 578T and MDA-MB-231 breast cancer cells 9197 64921 6489 2583 PMC6981417__F7 Differential ganglioside metabolism pathways between MDA-MB-231 GD3S+ clone #4 and MDA-MB-231 breast cancer cells 9197 64921 6489 2583 PMC6985587__F2 Predicted interactions among apoplastic proteins and signaling molecules in resurrection plants during dehydration 2922 2821 847 PMC6986441__F5 Canonical pathway (Modified from IPA) for GABA Receptor Signaling [−log(P-value) = 5.07; Z-score = NaN] 2557 55879 18 223 140679 10243 11337 1759 29979 4905 PMC6987193__F7 Schematic model based on our results showing the role of E2 in DCIS metastasis to IDC 3553 4314 999 79792 4615 3654 PMC6989314__F4 Pathway mechanism of the cell cycle 9126 6502 699 9184 5111 1017 1022 4661 PMC6989408__F5 Mitochondria-associated ER membranes in normal versus cancer cells 81542 23241 9217 9927 55669 PMC6990892__F13 Pathway signaling network generated from the top-ranking 100 DM promoters 3817 79602 207 6197 2534 5594 26060 5566 1147 6195 9212 5348 4056 1111 2033 8031 PMC6991631__F7 Proposed model of mifepristone for the treatment of adenomyosis 983 1017 1000 7852 PMC6993496__F6 Positional relationships of CDKN3-associated genes in the cell cycle 4087 4088 4089 4193 6502 9184 699 5111 993 1017 1022 4661 999 990 1874 1869 10926 23595 4999 5000 PMC6994583__F1 Pathways of H2S production 7263 875 5212 847 PMC6995234__F7 Expression of genes in central metabolic pathway in wild-type (WT) and engineered M 2539 6120 8789 2203 7083 2597 5232 4967 5132 4397 2271 PMC6996089__F1 Bile acid synthesis pathways 10858 1593 51302 80270 9420 1582 1109 5825 10998 8309 23600 3295 4280 570 25801 PMC6996369__F6 Scheme of predicted AJP001 signaling and the antibody production induced by the AJP001 conjugate peptide vaccine 3553 7099 114548 7054 PMC6997227__F2 PI3K/PIP3 signaling activates Akt signaling via Akt/PDK-1 activation, which results in the downregulation of apoptosis 3479 3667 5728 5163 PMC6997384__F3 Erythropoietin and its derivatives: from tissue protection to immune regulation 3560 3559 2056 920 5447 3716 7175 2885 324 PMC6997601__F2 MVA pathway and the synthesis of astaxanthin and ergosterol in X 4598 4597 3652 PMC6997842__F1 Brain-derived neurotrophic factor (BDNF) mediation in the anti-inflammatory and neuroprotective response of Alpha-melanocyte-stimulating hormone/melanocortin 4 receptor Alpha-MSH/MC4R against damage produced by excessive alcohol consumption 572 627 3553 PMC6998363__F5 hsa-miR-4638-3p and hsa-miR-1273 g-3p Target Gene Network Map 3479 10398 56034 91807 6654 4087 5578 3690 64750 53358 3397 3480 659 5062 4089 5063 5519 2534 83729 6093 4660 4091 10000 93 10451 657 83660 60436 2321 91 8516 2064 4838 1956 7143 PMC6999830__F1 Mitochondria as a regulator of inflammation 3553 3661 114548 7019 57506 7189 10010 PMC7002574__F4a Pathway and network analysis of more than 2500 whole cancer genomes 213 6647 54894 10735 3206 58508 196528 57534 7832 8125 675 7403 4778 55193 8085 5788 472 6659 3169 7091 11335 607 6927 7025 10370 29117 6598 6657 1387 8553 5464 79718 84962 4982 4851 4853 2625 6597 9314 678 10468 3398 4089 4221 8405 6662 5925 92 51755 7015 5101 4780 1616 7048 55294 7157 8242 865 7428 324 4848 4609 999 1499 10236 51514 1029 6429 1026 6125 841 3192 1974 27316 8683 5573 5728 220988 51585 1654 7555 23451 6794 60 1969 3189 673 5879 9817 387 7424 4915 5649 51684 4893 1956 6146 805 4763 2909 5796 4628 3845 5295 581 22800 6844 10787 3265 5335 567 5836 5727 56940 2596 5329 1281 3105 3215 PMC7002875__F8 KDM5C is a SAHA-sensitive marker of a druggable pathway damaged in NDDs 23133 8242 7552 170302 627 6853 6326 PMC7003279__F5 Genes of differential proteins in the interaction network 7018 116844 5157 1114 7369 5243 6406 6407 350 119587 3077 255743 1604 57758 3845 3949 3265 5906 7037 338 336 4018 5894 1378 345 335 5660 19 4179 7534 283871 4831 348 PMC7004076__F4 Molecular mechanisms of YQCT 5914 7098 2255 717 2263 2475 PMC7004516__F3 Association of efficacy of 5‐fluorouracil (5‐FU) and metabolic changes in cultured colorectal cancer cells 5226 6120 5213 5214 22934 6888 230 7167 5232 23305 31 39 47 2026 3417 5106 3420 1737 1743 1738 3945 5091 4190 8803 4191 8802 2271 6390 PMC7004849__F2 Cells within the skeletal niche utilize long chain free fatty acids (LCFA) for energy generation via two complimentary cellular catabolic processes of the carnitine shuttle and Beta-oxidation 1376 3949 3156 255738 PMC7004969__F1 Selected important players of osteoblast differentiation 5741 27122 6348 9242 PMC7005898__F6 Proposed function of HadDMtb in the mycolic acid biosynthetic pathway of M 717 341567 727 PMC7006128__F6 Innate immune system pathways showing Native American ancestry enrichment 3929 23643 929 7099 54106 9447 4615 834 51135 9636 6348 414062 3627 56832 PMC7006459__F1 Fyn activates divergent signaling cascades in effector lymphocytes 3932 2534 5728 27040 8915 10892 PMC7012465__F2 Regulation of hepcidin expression (adapted from Silvestri et al.) 7018 654 650 148738 164656 7036 3077 4089 4090 4086 7099 3569 151176 3570 6774 PMC7012898__F1 Upstream and downstream targets of the TOR Complex (TORC) in plants 64326 8667 6194 PMC7014054__F15 PtNPs change transcriptional networks 4929 3164 860 2353 468 7124 1958 3727 3725 6773 1960 1959 4094 467 1831 PMC7014913__F2 Pathogenic alpha-synuclein transmission 120892 55737 6622 2629 PMC7017070__F7 OncomiRs miR-221 and miR-210 and their impact on cancer cells 7077 4318 4089 81671 6778 79966 3198 1026 5770 PMC7017171__F1 Phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway 5105 367 2475 PMC7020470__F6 Schematic diagram depicting MetAP2 implication in different pathways 998 10988 572 4193 PMC7020744__F14 Role of RKI-1447 in liver cells and the TLR4/TBK1/IRF3 signaling pathway 387 6093 9475 7099 29110 3661 PMC7021580__F3 MED12 and Cancer Drug Resistance 1950 9968 1956 7046 4087 4088 1499 4089 1000 9439 2002 10498 PMC7022881__F1 Two signaling pathways that respond to extracellular glucose in Saccharomyces cerevisiae 27010 2634 2633 PMC7028286__F5 Top two modules from the PPI interaction networks 928 7037 975 967 351 2335 4924 2022 51280 7076 2744 334 6510 3099 6513 6505 PMC7028932__F2 Oncogenic pathways activated in T-ALL, the downstream signalling network of interleukin-7 (IL-7), NOTCH1, and polycomb repressor complex 2 (PRC2), and potential therapeutic targets 4851 2475 2146 23512 5728 8726 5771 55294 PMC7031348__F2 Inflammation and muscle protein turnover 3479 3667 6774 2932 PMC7033461__F9 Upregulation of miR-101a Suppresses Chronic Renal Fibrosis by Regulating KDM3A via Blockade of the YAP-TGF-Beta-Smad Signaling Pathway 10413 55818 7003 7050 4087 4088 PMC7037253__F1 IL-10 production is metabolically regulated 7099 7097 4179 2475 6774 196 23411 5087 3586 PMC7047626__F2 Mitophagy and DNA Damage Signaling in Human Aging 3920 55187 25820 9958 57154 84749 55626 23770 192111 139341 664 65018 PMC7048131__F2 Advances of the STAT3 signaling pathways involved in breast cancer progression 5008 1950 1956 56950 5771 6774 10013 283131 4513 PMC7049408__F1 AMPK signaling pathway: schematic model depicts the main upstream regulators and downstream effectors of AMPK 100034703 29904 1938 PMC7049637__F2 Proposed mechanisms involved in the anti-fibrotic activity of curcumin by inhibiting the activation of PSCs to acquire myofibroblast-like phenotypes 100653366 3569 3603 59 2335 PMC7050137__F3 Different epigenetic signaling pathways regulated during TGF-Beta-induced EMT 10419 3720 8091 8726 999 2619 23135 5929 4088 9869 2146 9839 3065 1786 6935 PMC7052944__F5 Regulatory effect of GPC3 on the WNT signaling pathway 2719 387 2932 1499 PMC7053123__F4 Gemcitabine resistance and metabolism 7462 2194 2475 8239 3417 10135 4582 2203 1869 6774 6241 7157 PMC7053243__F9 Schematic diagram showing the proposed mechanism of MYC inhibition by excess BASP1 protein competing for binding to CaM 10409 4609 4149 PMC7055192__F3 Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies 4035 3949 348 9619 PMC7056575__F1 Signaling via the PI3K pathway and inhibition of PGE2 production by NSAIDs 5163 5728 2932 572 7249 7248 PMC7056731__F1 Simple scheme of the Hippo pathway in mammalian cells 1950 4771 83593 4485 9113 26524 PMC7056731__F2 Reciprocal augment of Hippo-YAP signaling and innate antiviral response 3454 3455 4485 3654 3656 7098 115004 57506 6772 7187 6773 9113 26524 29110 3661 10379 3716 7297 PMC7057654__F2 Vaccinations can inhibit the release of various pro-tumor cytokines 8205 382 3845 7490 PMC7057934__F7 Schematic model of the underlying mechanisms of miR-126-3p-mediated suppression of proliferation, migration and invasion through the PI3K/PDK1/AKT pathway 5163 572 6093 5335 2932 581 595 5058 PMC7059124__F1 Schematic illustration of the autophagic pathway 2475 8408 9706 7405 10533 64422 9140 9474 83734 PMC7059124__F4 Hepatotropic oncogenic viruses and their impact on autophagy regulation 6461 2475 8408 9706 64422 10533 23411 9474 9140 7405 619501 8678 PMC7060614__F1 Alterations of the propionate pathway in times of acute metabolic decompensation 10993 25859 1491 4163 5095 162417 1373 84693 5009 27249 PMC7063158__F1 Schematic diagram for T cell activation and mechanism of IP3 activation 940 857 5091 4666 PMC7064006__F13 Possible metabolic pathway maps associated with the lipid biomarkers in dampness-heat induced diarrhea and dampness-heat induced diarrhea with PD treatment 10715 4018 283871 5091 PMC7065375__F7 Part of the KEGG pathway “Focal adhesion” 387 7408 3611 5728 2534 1398 3725 2002 126669 2885 572 PMC7068598__F2 Emerging signaling pathways in CSCs 10643 1956 4609 2475 1499 6774 90865 79923 574444 6608 85451 23411 PMC7069124__F3 Consensus around the TLR4 signaling pathway in three major pathway databases 7099 5606 5596 1147 114609 100187907 PMC7069528__F1 Effect of cannabidiol (CBD) in Parkinson's disease and Alzheimer' disease (AD) 351 7442 2166 3553 6285 2670 PMC7071808__F2 Oxidative stress in TGFB1-mediated fibrosis 7189 4087 4088 PMC7072125__F8 Molecular regulatory mechanism of Wnt/Beta-catenin signaling, induction of extrinsic apoptosis pathway by natural bioactive TA in NCCIT cells, and role of mROS in TRAIL-mediated extrinsic apoptosis induction with TA treatment 8717 1499 6657 79923 PMC7072699__F1 Metabolic pathway of sialic acids in mammalian cells 10020 54187 4758 140838 4759 10825 55907 129807 10559 PMC7072724__F8 PP2A regulation by S67/S62-phosphorylated ENSA/ARPP19 in human platelets and the impact of PKA/PKG on it 7408 2029 10776 PMC7072767__F4 PINK1-Parkin pathway regulates IPAS expression and inhibits neuronal death 65018 6015 1283 PMC7072884__F1 Schematic display of G-protein-coupled receptors (GPCRs) signalling in cognitive impairment 640 638 842 PMC7073073__F8 Representation of ATF6 acting on the TGFB–Smad pathway for induction of fibrosis genes 56937 4087 57154 4089 64750 1277 22926 7046 PMC7073187__F1 Main mechanisms by which the breakdown of tolerance to food antigens can occur 90865 85480 386653 64806 3565 3596 3567 PMC7076852__F7 Summary diagram of the proposed mechanisms underlying protective effects of C3G against glutamate-induced oxidative/ER stress apoptosis in HT22 cells 847 1878 8178 PMC7076893__F8 Critical pathways of the potential Alpha-glucosidase inhibitors from RS 3630 3643 5580 6256 5170 PMC7078051__F4 Iron homeostasis disruption in HLRCC 8452 8453 9978 7428 2512 2495 2305 9817 PMC7078196__F6 Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation 3480 5045 7249 PMC7078475__F1 Biochemical pathways involved in central carbon catabolism in P 100187761 1896 2203 2023 11113 51430 4118 6392 6390 6389 10296 PMC7080988__F2 Computational Model of the Endothelial to Mesenchymal Transition 54567 2247 7476 2313 2624 441478 4086 4087 51176 7422 8829 4091 6615 7291 6774 2113 6591 6935 9839 PMC7082326__F1 Mitochondrial PTEN-succinate axis promotes P 1080 7099 5728 3553 114548 58484 PMC7084654__F6 Hypothetical alterations of the metabolic pathways for ATP production in low-oxygen stress response 5132 4397 7143 PMC7085407__F3 PGC-1A signaling pathway in response to ROS/RNS 23410 5728 7019 9997 PMC7086291__F3 Tec kinase signaling 6714 7006 100124696 PMC7086291__F4 Osteoarthritis signaling 1280 2487 1499 51384 4843 4322 1999 9507 7099 3579 121340 4086 PMC7096478__F7 The possible mechanisms used by M 182 4851 324 3280 920 PMC7096478__F8 The possible mechanisms used by M 182 54831 861 PMC7097452__F2 Prognostic and predictive enrichment in sepsis 1524 84658 10871 2867 7052 9034 7040 7045 3360 1088 3576 26525 50486 7124 81501 4814 3273 1164 5996 5557 23764 54210 406912 100133941 7462 54541 406934 6003 4047 PMC7102884__F1 Exhibits the involvement of transduction pathway in AML 6387 7852 2475 PMC7105577__F2 Crosstalk between major signaling pathways during nephron progenitor cell (NPC) differentiation 22943 6422 79633 238 2932 2885 8313 4485 324 2549 9113 26524 1499 PMC7107758__F4 Resistance mechanisms to BRAF and MEK inhibitors in BRAF-V600E melanoma 3084 1950 3082 2885 4763 5728 2475 4286 PMC7108978__F2 Simultaneous utilization of 2H and 13C tracers provides insights into distinct pathways of hepatic metabolism 4118 11113 717 718 PMC7118125__F3 Signaling networks in immunometabolism 940 10645 201163 57600 96459 1499 56947 8408 PMC7122562__F2 Viral infection suppresses autophagy 8408 3667 64422 PMC7122562__F3 Viruses manipulate autophagy to promote their replication 57506 375 8729 345611 7284 9140 7249 9474 64422 7405 55014 9342 9695 PMC7124275__F9 MAPK7-CEBPB signaling cascade negative regulation of mir128-3p under ischemia/hypoxic condition 5598 1385 3667 PMC7133116__F2 Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 22934 6120 8789 2203 1896 283871 3250 5162 6389 PMC7135884__F3 Metabolic adaptations after phagocytosis and inflammatory stimulation in macrophages and microglia 2475 3603 3553 PMC7136162__F2 Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs 7124 7018 7035 718 PMC7136521__F1 Angiogenic and vasculogenic mimicry promotion by CSCs is mainly triggered by VEGF among several types of cancer 947 1003 1232 6774 22943 2535 PMC7137211__F1 PI3K/AKT/mTOR axis and its alterations in breast cancer 2260 5728 5163 7249 PMC7137344__F1 Functional alterations and HSC aging mechanisms 3716 942 2932 11126 7249 6403 2475 6009 10628 6098 PMC7137714__F6 Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse 652 332 3569 83593 595 7042 699 330 1870 995 9700 7272 1032 PMC7137946__F1 Biosynthesis and metabolic pathway of BH4 367 6697 7054 1719 5053 PMC7137995__F5 Elucidation of Functional Roles of Sialic Acids in Cancer Migration 8869 6489 4758 51083 6482 6761 8705 2583 2720 2760 29906 400410 PMC7138402__F5 Schematic model by which RACK1 promotes the progression of OSCC 10399 942 941 1236 7097 7099 9332 PMC7138577__F7 Proposed model of the combinatorial effect of DDP and melatonin on NPC cells 7471 2932 324 1499 894 6662 960 PMC7139589__F3 Extracellular domain consists of five cadherin-type repeats bound together by calcium ions, forming a parallel cadherin dimer 1950 1499 595 1956 PMC7139637__F3 Crosstalk between YAP signaling pathway and both TEAD and TGFB pathways 10716 4087 4088 4485 4092 9113 26524 4089 PMC7139637__F4 YAP drug targets 4485 9113 26524 6714 23476 PMC7140477__F1 Major carbohydrate metabolic pathways 6518 5132 3466 355 2744 6510 717 PMC7140616__F2 Activation of the canonical Wnt pathway in head and neck cancers is mediated by various factors 1950 1798 1956 2932 57650 1499 595 107966124 PMC7141137__F3 Intracellular regulators that link morphogen signaling pathways during DV and AP patterning of the ectoderm in vertebrate embryos 6496 27023 1196 7541 1499 2128 PMC7145763__F5 Human BNB junction complex formation: The GDNF-CREB1-SRC-CTTN/CTNNA1/CLDN4-SEC31A hypothesis 2668 2674 1385 5979 6714 22872 2017 1364 1495 PMC7145987__F4 DNA damage response defects in high risk neuroblastoma (HR-NB) 4613 4361 1111 641 9212 993 4149 3014 472 545 PMC7147660__F1 PD-1/PD-L1 pathway and anti-PD-1/PD-L1 agents combination strategies in breast cancer 3146 84890 3620 1019 1021 PMC7148120__F3 Microglial activation on metabolism 3458 6376 1524 PMC7150781__F3 HBV suppression of type I interferon (IFN) response (Green arrows indicate the related signaling pathways and T-arrows in red indicate blocking the targets) 7098 57506 6773 10379 29110 3661 4938 PMC7151642__F1 cGAS-STING signaling in immunity 11277 3661 29110 5970 PMC7151642__F3 Tumor Suppressive Roles of cGAS-STING 115004 6573 3661 5970 PMC7153006__F12 Schematic diagram depicting the cytoprotective effects of Kaji-ichigoside F1 and Rosamultin on hypoxia-induced apoptosis of EA.hy926 endothelial cells 572 581 596 2021 PMC7156451__F9 Glycogen metabolism regulates macrophage-mediated acute inflammatory responses 5236 6772 5915 5836 2997 PMC7158706__F4 Upregulation of interferon signaling pathways 3458 7297 8651 8554 10379 581 3659 5696 3437 2619 3716 3430 2597 PMC7160326__F1 Different WNT signaling pathways 4920 4040 4041 23500 23002 324 2932 387 1499 PMC7160326__F2 The proteins that underlie Robinow syndrome or omodysplasia (indicated in red) in the WNT/planar cell polarity (PCP) pathway 7474 2535 2239 10082 4920 1855 1857 23500 23002 64359 5881 387 PMC7161696__F9 Pathway of hyphal formation 8481 4977 4004 998 27010 3084 PMC7163451__F8 Schematic diagram about the central role of co-treatment with Beta-elemene and cetuximab in ferroptosis induction and migration inhibition 55240 2879 7018 30061 23657 6520 PMC7164249__F1 Merlin regulates different developmental signaling pathways 1499 999 998 5879 5062 324 55914 1956 PMC7167284__F3 Chronic HCV replication in liver cells induces a multifaceted stress response 975 1956 3949 29881 100506658 9076 PMC7168269__F1 Roles of gastric cancer stem cells (GCSCs) in the immune microenvironment 6387 4087 6774 PMC7168513__F4 DENV‐mediated activation of the cytosolic DNA‐sensing pathway in DCs 115004 29110 3661 PMC7169117__F5 Schematic illustration of the major EBV proteins and corresponding targets, by which EBV modulates the TGF‐B signaling pathway 4089 5796 467 3397 PMC7171049__F6 MiR-29c alleviates renal fibrosis via TPM1-mediated suppression of the Wnt/Beta-catenin pathway 1499 7040 7168 324 PMC7175546__F1 Participation of WEE1 kinases (Cdk1 inhibitors) and CDC25 phosphatases (Cdk1 activators) in the regulation of the activity of Cdk1 kinase during G2 and M phases 84126 545 7465 983 PMC7175546__F2 DNA damage and replication checkpoints 84126 545 8914 54962 PMC7177247__F8 CBD blocks the IL-1B/IL-1RI/Beta-catenin pathway and induces an epithelial phenotype 5879 999 330 3397 PMC7178465__F3 Increase of intracellular calcium activates neural nitric oxide synthase (nNOS), causing increased NO levels 4704 847 23410 8564 PMC7179076__F2 Wild type (wt) p53 and mutant (mut) p53 expressed in tumor cells on anti-tumor immune responses and inflammation 940 3569 6774 920 100302142 6361 6280 PMC7179196__F1 PPARA and PPARG signal cascade following their activation by endogenous or synthetic ligands 706 627 7124 3717 PMC7182067__F1 The Regulation of Coagulation and Thrombosis 8462 3146 7450 11093 7018 54822 5898 5899 PMC7183444__F3 Hypoxia/re-oxygenation-related KEGG pathway and differentially expressed genes(a) von Willebrand factor (VWF), complement component 1, q subcomponent, A chain (C1QA), and complement and coagulation cascades pathway 7450 712 2161 2271 2147 2152 718 2155 7035 2159 5091 1431 1380 1361 928 735 7454 9560 414062 7852 7975 572 1794 6010 1610 PMC7183504__F2 Key interactions of BMX and its pathways 387 5310 5058 6772 660 6774 80230 5292 7006 100124696 3702 7294 7124 695 PMC7186480__F7 Possible cross-talk of IFNs and the AIM2 inflammasome pathways in AMs from TB patients (AMTB) modulated by M 3458 7097 7099 929 4615 9447 7189 6772 6773 834 3659 6890 3437 PMC7186717__F2 Influence of the Hippo-YAP signalling pathway on tumor associated macrophages (TAMs) and its implications on cancer immunosuppressive microenvironment 4485 3383 941 PMC7191850__F7 Graphical summary of MITF action as a potent antioxidant in RPE cells through regulating NRF2-dependant antioxidant signaling to protect the neural retina against oxidative stress-induced degeneration 2729 2730 4286 4094 6120 PMC7192829__F2 Regulatory mechanisms involved in vitamin D-induced autophagy 7421 7097 7096 51311 759 2475 7942 PMC7193283__F3 Mechanism of TSG on improving NAFLD 5465 1571 1581 64240 355 7038 PMC7195008__F1 Pathophysiologic Model of Immunothrombisis in COVID-19 920 59272 1636 7018 PMC7195637__F1 mTOR signaling pathway and its functions 7249 7248 64798 5091 7942 9776 PMC7195839__F3 Non-linear reverse-engineering method for inferring genetic regulatory networks 4005 2113 863 6886 4851 861 2624 PMC7198573__F3 Map of the T-cell receptor signalling KEGG pathway for Mus musculus, with the colour of nodes representing the level of individual variability in response to stimulation with anti-CD3 and anti-CD28 antibodies in Microtus agrestis 920 916 2534 917 919 7535 5600 915 4690 5058 9402 27040 387 2885 5530 50964 10125 3265 5894 5594 2353 1470 7124 1019 6885 4790 84433 959 3551 10892 8517 1147 29851 207 1326 9020 940 5170 2932 PMC7198842__F3 Chronic phase-CHIKV mediated joint pathology: in the joints, osteoblast cells (Bone-forming cells) are susceptible to CHIKV infection causing over-expression of IL-6 and RANKL and inhibition of osteoprotegerin (OPG) 6347 7189 2444 PMC7199749__F1 Genomic stabilization by TTK 7272 57082 699 9184 PMC7199893__F4 FATE OF ALT-INHIBITED CANCER CELLS 1616 546 5371 85453 545 23137 79677 57697 7156 641 5893 128710 10635 PMC7202522__F5 USP22-pivot gene-module-pathway network suggesting USP22 could affect multiple pathways by up-regulating UBC 1390 5469 1174 9179 7939 7316 23326 10054 4609 57192 950 6041 6272 324 991 994 995 993 51465 55284 11065 7319 118424 9246 983 999 1017 990 9133 26232 8651 PMC7203474__F2 Iron recycled and released by TAMs sustains the cancer progression 7018 1356 3934 286133 8205 PMC7204122__F8 Merged network showing the interplay between IL6-mediated signaling and interaction, binding, and adhesion of endothelial cells 6402 2078 633 975 5781 6401 3815 5329 6387 729230 4791 1025 3964 3791 3676 3717 5468 1869 960 9021 1956 1386 6774 7450 3725 367 4609 2353 5241 1000 6678 214 PMC7210546__F1 TLRs and signaling molecules on the basis of literatures 7099 7097 10333 7100 114609 4615 51311 51284 3661 7189 54106 PMC7212408__F2 Activation of MAPK signaling pathway in BCSCs 1956 1950 1852 80824 2625 2309 677 79923 406984 6591 331 23512 PMC7213603__F4 Schematic representation for a proposed pathway showing upstream regulation of EZH2 in SLE CD4+ T cells 64798 2146 2475 64223 PMC7214455__F1 Taking aim with IAP antagonists at triple-negative breast cancer: a moving target no more? 8737 841 8772 7186 8717 197259 11035 836 PMC7215568__F2 Action of MNKs 2885 2475 64798 9894 1977 3178 10253 51129 1499 595 10397 4838 331 4087 1017 6935 PMC7216071__F8 Activation mechanism of miR-223 negative regulation of the TLR4/MyD88-NFKB signaling pathway 4615 114548 3553 PMC7216212__F3 Dichotomic Role of Macrophage Migration Inhibitory Factor in Neurodegeneration 8841 4282 2670 PMC7216437__F3 ATM functions in DNA damage repair pathway 6741 3014 472 11200 545 1111 7515 5423 675 79728 672 5888 7974 PMC7218496__F9 Mechanism of AA on attenuating hypertrophic and fibrotic differentiation 6662 1277 1280 176 860 1300 PMC7219929__F3 Schematic depicting the response of steroidogenic cells to stressors such as polycyclic aromatic hydrocarbons and ROS 9817 6667 706 PMC7222508__F6 Network of 145 candidate genes with main drug metabolism pathway genes 5800 5793 29102 103 331 5476 1508 8301 2475 4163 324 9612 6655 PMC7226210__F2 The most relevant molecular pathways and targeted agents in TNBC 2885 3667 5728 5163 7249 7248 367 672 PMC7226273__F5 Proposed mechanism for Vinorelbine’s radio sensitizing effect 545 472 995 PMC7226524__F2 Methionine metabolism 27430 4144 4143 PMC7226605__F3 Anti-cancer effects and cell death pathways regulated by cannabinoids and the classical cannabinoid receptors 83939 468 57761 2475 PMC7226777__F1 Principal functions of the 18-kDa translocator protein (TSPO): initiation of programmed cell death, including apoptosis, as well as regulation of the cell’s nuclear gene expression 4609 2353 1195 3399 7286 581 706 PMC7227208__F6 TGF-beta signaling pathway enriched in KEGG 4756 148738 4089 25805 3458 7124 2200 79875 9978 8454 6500 7057 1874 4087 4088 2331 6667 1616 387 10468 4092 4838 PMC7228650__F2 Epigenetics of colorectal cancer: biomarker and therapeutic potential 1956 1950 5921 4087 4088 5728 4089 407035 27250 4316 4609 1499 100124700 60674 324 3091 4041 999 PMC7229175__F7 BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis 7099 377 4615 114609 PMC7229984__F1 Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival 6469 1956 10818 55851 339175 10683 182 5727 10000 5728 6608 1019 4193 1454 51684 25832 4194 2735 5927 2737 11011 898 PMC7230378__F5 Cytoscape analysis considering TRAIL and miR-106b-5p in the apoptosis pathway 8743 10018 1520 5534 5567 841 208 4893 5290 8737 840 355 5599 2081 9451 331 835 842 5170 7157 3709 317 153090 54205 51135 596 PMC7232018__F1 Schematic view of the role of lysosomes in the autophagy pathway 7942 2475 9776 2720 1509 79158 8139 23400 10133 10159 9896 718 140805 PMC7232439__F1 Schematic diagram for activation of innate immune responses and interferon (IFN) signaling pathway after influenza A virus (IAV) infection 3466 7297 10379 114548 57506 7098 3665 3661 9023 PMC7232694__F2 Adeno-Associated Virus Genome Interactions Important for Vector Production and Transduction 353497 2286 5111 5893 6667 7528 9869 54106 PMC7234984__F1 Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures 5334 1455 1020 5523 5506 3710 PMC7235403__F6 Effect of DEX on metabolic pathways in sarcoid AMs 3099 501 4329 314 226 2023 5315 2752 10157 4942 6303 2184 48 50 3420 133522 35 215 4967 6389 4191 39 8310 4696 4700 6392 7384 7386 440567 1337 1340 1351 1353 PMC7235403__F7 Lysosome pathway in DEX-treated sarcoid AMs 1513 5641 2717 2548 4669 2990 3373 4668 2581 6448 2588 2799 3988 175 53 23457 9516 138050 9114 10312 5579 PMC7237219__F7 The role of FGF signaling pathway in blood cell migration 5879 7272 5880 23213 PMC7238289__F1 Pathophysiology of Alcoholic Hepatitis and Mechanisms of Action of Novel Therapeutic Agents 50616 2919 3576 213 PMC7241359__F1 Methotrexate has been recognized by the World Health Organization as an ‘essential medication’, principally due to its broad diversity of mechanisms of action 5981 471 4524 7054 7298 1719 7097 59272 3146 7099 PMC7242738__F3 KEGG pathway for TNFA (bta04668) with the annotated DEGs in our results between Besnoitia besnoiti-infected BAEC cells at 32 hpi vs 7124 1431 8772 2353 1906 197259 7186 3725 PMC7243138__F2 Pin1-mediated APP processing 351 5300 2932 PMC7245796__F4 Metabolites on post-translational modification of EZH2 protein 5132 2821 47 5238 6675 2146 8473 PMC7246618__F1 Monoubiquitination in human diseases 55120 6596 5111 7319 2177 7398 83737 1956 8216 867 PMC7247819__F2 Activation and inhibition of the AIM2 and NLRP3 inflammasome in SLE, Ps, AD, and vitiligo 23654 4280 51284 9447 114548 3567 PMC7248321__F5 Multiple signaling networks are regulated by hsa-miR-205-5p based on ingenuity pathway analysis (IPA) 10602 10525 7296 4288 3675 1999 64151 1663 374 3178 4609 51230 84271 84864 10955 9474 79400 5970 5166 3678 2317 90427 5817 150368 10979 93323 3636 94 56907 1435 4254 57606 375056 128637 5901 5364 23303 10152 10783 2944 23647 54927 8476 51024 4281 57787 PMC7248557__F1 TLR4 Signaling pathway 3929 7099 4615 51135 3656 7189 7187 3661 114609 PMC7249489__F2 Signaling Pathways in Leukemic Stem Cells 5728 5163 64798 7249 7248 6009 PMC7253636__F1 Human pathway of assembly of lipoyl moieties on its cognate proteins 2653 387787 11019 51601 PMC7256023__F5 Lipid and choline metabolism in TGFBeta-induced EMT 4316 1119 6611 47 2194 6615 6935 10716 PMC7257252__F5 Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells 6352 26291 6774 1950 PMC7261637__F8 Model depicts the proposed role of HPSE in promoting stemness 2735 216 6657 10855 PMC7261959__F12 Alterations induced on SIRT1/PGC-1A pathway by ABOs 23411 55669 4899 7019 PMC7262827__F5 KEGG pathway analysis of differentially regulated genes in MCF7 cells after treatment with isopicrinine alkaloid, depicting the affected genes in p53 signaling pathway 1017 472 545 2242 637 10209 842 836 4193 64065 7249 5728 64326 PMC7262827__F6 KEGG pathway analysis of differentially regulated genes in MCF7 cells after treatment with isopicrinine alkaloid, depicting the affected genes that play significant role in cell cycle and cell proliferation 1874 4087 4088 4089 2932 6502 699 5111 1017 1022 4661 10926 23595 PMC7264416__F4 Protein–protein interaction (PPI) network and pathway involving the survival-associated features 11337 7054 10207 100187761 811 5111 3073 6955 79866 7349 6418 2669 2261 22808 2885 5140 3358 3929 929 114609 51135 27040 8631 3952 595 940 PMC7265137__F3 Simplified picture illustrating some examples of how microorganisms promote the cancer 7054 6774 3553 1499 999 PMC7267399__F2 Possible life cycle of SARS‐CoV‐2 and potential intervention strategy 59272 7113 5478 PMC7271281__F4 The ncRNA pivot regulator on the dysfunction module 126353 400550 643911 100126297 PMC7273093__F2 COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease 59272 1636 5547 5550 PMC7274160__F4 Possible signaling pathways of hsa-miRNA-122-3p and hsa-miRNA-200a-5p enriched by the KEGG pathway analyses 2002 6722 2885 2932 1499 324 PMC7275069__F2 FOXF2 acts as a crucial molecule in tumours and embryonic development 2303 7424 7291 7474 1499 6935 7078 4150 6667 2295 999 PMC7277983__F2 TNF-TNFR2 signalling pathway in the immunosuppressive cells 7124 7186 8737 PMC7279161__F4 Comparison of Nrf1 and sterol regulatory element-binding protein (SREBP) activation pathway 4899 55768 84301 4094 PMC7281113__F1 HOTAIR role in breast cancer (BC) drug resistance mechanisms with details of the main molecular pathways involved 1499 5728 572 1003 3236 100124700 7031 PMC7281175__F2 Metabolic pathways in hepatocarcinogenesis 5226 8803 47 4047 2182 7038 1717 4597 3156 1593 9420 570 1582 80270 2879 2937 18 290 2539 PMC7281640__F2 Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma 2767 2776 8314 23451 1964 PMC7281786__F5 Mitochondrial mediated immune functions and cell signaling 2357 3553 57506 114548 3458 54106 PMC7282943__F1 Transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas 7046 7189 9618 6010 4087 4088 4092 4089 PMC7283559__F1 C-type lectin receptor signaling in TB and HIV 4615 324 920 4360 PMC7285805__F1 STAT6 modulates pro-colitis and pro-cancer responses 8205 920 114034 PMC7286322__F4 LncRNA PTTG3P played different roles in different stages of NSCLC 9700 9748 9134 991 4609 9126 8318 9133 9184 7398 890 990 11200 55215 5426 4171 55660 29089 11157 2177 672 5983 10285 2956 4436 6426 22916 9156 PMC7286881__F14 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics 3606 107966124 3952 2244 3953 4023 4843 4049 596 207 5970 1129 22808 4547 6256 4842 5328 29881 2159 4878 4852 64805 5196 148 3791 5327 5360 5743 959 7124 3383 5624 3778 3643 6347 847 7018 338 7035 7045 7056 7057 7099 7450 PMC7287184__F5 Kyoto Encyclopedia of Genes and Genomes (KEGG)-enriched pathways and related genes 8795 27244 51512 6241 64065 598 55240 5268 983 11200 595 9133 2810 1017 995 7534 4173 8900 1022 991 7272 990 9088 699 8318 5347 4089 890 9232 PMC7287590__F3 Canonical aryl hydrocarbon receptor (AhR) activation pathway 9049 196 405 367 29 PMC7287590__F4 Proposed models of NLRP3 inflammasome inhibition via AhR pathway 196 114548 405 3553 PMC7288008__F3 Pathophysiology of Ulcerative Colitis 2625 3662 920 50943 2921 2919 3627 3576 PMC7288517__F6 Mechanisms of accelerated aging triggering PD 604 2170 10678 2712 50943 5937 119 PMC7289296__F4 1A, 25-dihydroxyvitamin D3 promotes the translocation of Beta-catenin from the nucleus to the plasma membrane, and competes with T-cell transcription factor 4 (TCF4) for Beta-catenin binding 999 1499 7421 PMC7289676__F1 ACE2, COVID-19, and ACE Inhibitor and ARB Use during the Pandemic: The Pediatric Perspective 545 1636 59272 PMC7290055__F4 Co-ordinately up-regulated genes of NF-Kappa B signalling pathway in HIV-H 183 27040 472 29760 638 8717 1540 10913 3586 114609 100187907 847 4049 4050 PMC7290580__F3 Signaling pathways by cIAP-mediated degradation of TRAF2 and/or TRAF3 7186 4615 7187 5966 7185 PMC7290813__F7 Graphical representation of selected intracellular effects and induction of apoptosis in mammalian cells following internalization of Shiga toxin holotoxins (Stx) 3603 114548 581 790 54623 PMC7290813__F8 Graphical representation of effects in mammalian cells following binding of Shiga toxin (Stx) B subunits to cell surface receptors 7450 613 4067 114548 8039 54623 PMC7293394__F1 Antibody-mediated complement activation in pathology and protection 717 1356 1378 1380 4179 613 1431 PMC7294616__F10 Anti-inflammatory signaling pathway mediated via OXA and OXR2 in ICH 55074 3240 3586 PMC7295848__F1 PI3K/AKT signaling cascades in cancers 5728 2638 100187761 619501 367 4609 5290 5091 PMC7299409__F5 miR-410-3p is induced by vemurafenib via ER stress and contributes to resistance to BRAF inhibitor in melanoma 673 6908 4763 1386 10682 7528 466 558 PMC7300268__F1 Regulation of YAP/TAZ 57787 154796 10494 5784 387 4485 60485 4771 9113 81788 983 51701 1499 7074 595 558 9686 4609 332 PMC7301642__F5 ATG8-mediated selective autophagy pathways in plants 4077 706 5004 PMC7303382__F8 Neuroactive ligand–receptor interaction pathway 2693 5724 2696 2862 2492 4018 100506013 6344 7442 5737 3952 3953 6865 5617 PMC7304922__F1 Activation of Nrf2 and AhR signaling pathways 9817 196 5053 405 PMC7305134__F5 TIE and the canonical TGFB signaling pathway regulated by ncRNAs 7046 4087 4088 406900 55384 64750 57154 4092 4089 5820 3458 7018 50943 PMC7307792__F4 Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei 5625 157739 2821 PMC7308516__F2 Microbiota in cerebrovascular disease: A key player and future therapeutic target 59307 4615 3654 51135 7189 324 7099 85480 9242 PMC7310461__F4 Alterations in TCR signaling pathway 5603 5530 5532 5533 919 5133 1493 1739 4772 4773 4775 1147 5534 5777 5535 5788 10892 3932 868 920 1019 998 5058 3551 925 3558 5062 5063 2534 8517 8915 926 7535 4790 3565 4690 27040 10298 3567 4792 4793 4794 84433 3937 5970 3586 7006 100124696 7409 57144 7124 1437 3725 7410 10451 915 5290 2353 6885 9402 5335 917 5291 3458 959 5293 5170 5588 5295 5296 8503 2932 4893 29851 5605 3845 3265 940 2885 10125 5894 6655 PMC7310461__F5 Alterations in the BCR signaling pathway 4863 10990 11024 6654 11027 6655 25780 2885 11026 3845 5336 3265 5894 23547 6850 79168 29760 10859 5579 10288 27071 4067 695 2353 84433 11006 8915 5970 3725 4792 4793 4794 933 3636 5879 971 973 7410 10892 8517 4790 5880 3551 974 2213 10451 5881 5290 4772 4773 4775 8519 5532 5291 930 5533 5293 5295 2932 975 5534 5296 1147 5535 1380 8503 PMC7310559__F8 CYT997-induced apoptosis in GC cells 3717 6774 595 PMC7313395__F3 Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the Cell Cycle Pathway in Trypanosoma cruzi-infected myoblasts 5885 6502 7939 10735 472 PMC7316184__F1 Trimethylamine N-oxide (TMAO) metaorganismal pathway 9429 114548 2308 PMC7316886__F2 Innate immune responses of airway epithelial cells to RV 4615 4843 51135 7189 57506 29110 7187 3627 2919 6374 3576 3661 3659 58191 3383 PMC7319342__F7 ROS regulation of RAS and vulva development in Caenorhabditis elegans 50506 6647 6648 PMC7320879__F1 Toll-Like Receptors 2 and 4 in the Pathogenesis of Chronic Obstructive Pulmonary Disease 7097 6097 50943 7099 260431 PMC7322352__F4 MAPK Signaling PathwayGenes in the pathway are colored based on their expression in TN tumors 2885 6722 5894 4763 2316 7124 8717 7186 4149 355 1616 929 51295 51701 PMC7322352__F5 MAPK Endogenous RNA NetworkThis figure shows the network of interacting protein-coding mRNAs and non-coding microRNAs in the MAPK singling pathway 6772 6774 4772 466 2002 6722 1977 572 5156 3925 5829 7048 6714 408 284 2885 7444 5923 7040 5532 1398 1843 3082 5879 5567 781 3654 4609 2318 80824 4763 1793 673 5494 4342 3479 3611 PMC7324605__F5 Polyamine pathway in patients with Diffuse Cutaneous Leishmaniasis 6303 6723 6611 PMC7325485__F1 The dominant control mechanism by which Nrf2 activity is regulated occurs through its association with the E3 ubiquitin ligase KEAP1 and subsequent ubiquitination and proteasomal degradation 8452 8878 79728 192111 2877 3162 2946 2729 4094 PMC7326156__F7 Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E 1977 2475 6194 PMC7326806__F5 Reciprocal regulation between brain cancer and neuronal cells in the brain 4089 351 102 54413 759 PMC7327974__F3 A) A model depicting the regulation of apoptosis through the TNF pathway and B) Simulation of the signaling process 1950 7422 7124 3791 1956 572 2475 581 54205 PMC7328459__F1 Dysregulation of Cell Death in Human Chronic Inflammation 717 10454 7186 7188 23118 5970 7124 8717 8737 81858 90268 1540 8772 11035 PMC7331943__F3 Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression 5166 5091 717 718 9212 87 948 PMC7332497__F3 Cytosolic and sub-cellular engineering of yeast for isoprenoids biosynthesis 100 3652 3422 PMC7332542__F2 Genetic modifications for the establishment of a reductive, carbon dioxide fixing, and redox-neutral pathway from extracellular glycerol to extracellular SA in S 128 4191 4190 48 PMC7332664__F1 Cores of the HIF pathway and the Hippo pathway 7428 4485 60485 9113 26524 PMC7338450__F2 GA12/13 signaling in metabolic diseases 387 9475 23326 23411 PMC7338561__F2 Depiction of the modulation of NFKB signaling pathway by gastric microbiota, especially H 4615 10392 1499 PMC7338805__F7 Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress 5702 4899 4094 PMC7339077__F2 Biomarkers of primary and acquired resistance occurring in the (A) tumor microenvironment (TME), (B) in the tumor, and (C) host factors 3902 201633 1499 567 5728 PMC7343507__F7 The regulatory role of miR-9 and miR-29a in DPN 3670 6469 759 PMC7343815__F4 Autophagy as a modulator of cell death machinery 10533 9474 7939 PMC7345850__F9 Left panel: Balanced autophagic flux 8878 4074 3916 120892 PMC7346011__F8 The anti-inflammatory mechanism of P22077 7189 3553 7099 PMC7348176__F7 Anticancer mechanism of HF for HCC 1017 595 1021 1019 331 PMC7348178__F6 VEGI‐251‐induced TAM apoptosis 8205 8717 7186 PMC7349003__F2 Role of lncRNAs in the drug resistance of triple-negative breast cancer (TNBC) 382 100750247 6117 283131 5728 283120 PMC7349502__F2 N-glycan trimming of the HBV envelope glycoproteins 6400 55741 9695 80267 PMC7350315__F3 Schematic overview of the classical ATM and ATR DDR 5884 545 84126 472 3014 2177 55215 PMC7352359__F3 Current model of regulating the BRI1 abundance on the plasma membrane (PM) 6642 10211 578 PMC7352566__F1 DNA Double Strand Break repair by Homologous Recombination or Non-Homologous End-Joining pathway 672 112441434 54537 675 55183 5888 PMC7352599__F2 SRC constitutive activation modulates inflammation and metabolism concurring to tumor microenvironment sustainment in GBM 8205 6714 6774 PMC7354282__F2 Role of the farnesoid X receptor (FXR) and bile acids 1356 9971 344 7157 348 545 5950 1191 336 1956 324 341 335 338 350 PMC7354740__F1 Leptin action in granulosa cells 3667 2885 1588 PMC7355051__F3 Targeting mitochondria using endogenous cardioprotective strategies 9927 6774 2638 2932 PMC7356051__F1 Mammalian Arg/N-degron pathway 197131 23304 23352 51366 123803 11101 55093 PMC7356262__F6 Canonical pathway “Osteoarthritis Signaling” for VA vs 4089 121340 1499 8841 6662 6667 3146 283120 1280 4319 650 10135 PMC7359176__F2 Phosphorylated glycogen synthase kinase-3B (pGSK-3B) and canonical WNT/Beta-catenin signaling in “on” state 4040 4041 1499 324 PMC7360684__F2 Canonical TGFB signaling pathway and TGFB signaling targeting therapies 100187907 4087 4088 4091 4092 4089 4609 PMC7361619__F1 COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches 59272 4023 3949 1071 348 335 5444 3931 9619 19 4284 4050 59272 4050 4284 5444 1071 3931 4023 9619 3949 PMC7363928__F8 Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling 7099 1003 3939 3579 2919 PMC7364656__F7 Sal and Das together synergistically inhibited the BRCA1 pathway in the MDA-MB-468 cell line 84126 545 472 2022 6772 580 466 2956 571 4292 10111 5347 4361 PMC7365859__F1 Legend: A schematic view of the involvement of zinc in various signaling pathways 4609 10010 2335 PMC7365923__F1 Artemisinin-family drugs for cytokine storm in COVID-19 114609 6369 3458 6775 3569 7187 7189 3717 PMC7365992__F4 Apoptosis and genes involved in oral cancer - a comprehensive review 56616 790 7939 57099 572 PMC7365993__F2 RAS-RAF pathway in relation to miR-31 and RASA1 1956 2885 5921 2353 PMC7367293__F6 CREB signaling in the Xenopus laevis whole brain after exposure to 24 h of a predation threat from the larval salamander, Hynobius lichenatus 2885 6908 2002 PMC7367500__F1 Canonical and Non-Canonical Wnt Signaling in Immune Cells 999 4040 4041 54894 84133 55366 8549 1499 324 6259 998 5879 387 PMC7373816__F2 Metabolic regulation of the Hippo-YAP signaling network 8473 154796 115004 3661 4485 3481 9113 26524 57608 387 2475 PMC7373860__F5 Frequently altered cancer pathways for TP53 using gene set enrichment analysis pathway enrichment in hepatocellular carcinoma 355 7157 5608 5924 1439 3304 2316 572 1021 1019 5934 1874 1029 595 1030 1017 1870 5925 1027 898 545 581 79370 PMC7374064__F6 Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cells 1869 26959 27161 92140 1871 1278 5813 5925 7157 4609 4869 5465 639 351 6774 PMC7376204__F6 Significantly enriched KEGG pathways for a down-regulated gene set after 24 h CM03 treatment 2475 83667 2932 64798 5728 PMC7376370__F8 Proposed mechanism and pathway of RUT in suppressing DSS-induced IBD in mice 3162 4094 6647 PMC7376809__F1 An update on stem cell therapy for Asherman syndrome 2932 324 1499 4089 4087 4088 6657 999 PMC7377265__F7 Proposed Model Illustrating the Role of GABA and GABAB1R in PTGs 3258 846 5741 PMC7377830__F2 Tomatidine-target genes associated with the top two KEGG pathways 5894 673 5604 5605 2353 6195 PMC7378668__F5 Genes and processes involved in the 04145.Phagosome pathway 53407 9341 8411 811 7097 929 7099 10333 8685 923 83547 203068 4353 4074 PMC7378668__F6 Genes and processes involved in the 04660.T cell receptor signalling pathway 1493 962 3932 867 2534 7535 27040 2885 3702 10125 1019 8915 1610 29851 PMC7378668__F7 Genes and processes involved in the 04662.B cell receptor signalling pathway 933 971 6850 613 4067 29760 695 2885 8178 8915 975 930 PMC7379270__F3 The mTORC1 pathway 64798 64223 468 8408 6009 7189 7248 7249 PMC7379745__F1 Macrophage M2b polarization 7187 7189 6850 3661 PMC7381543__F2 Molecular and metabolic regulation of effector and memory T cell differentiation 920 958 324 970 941 942 940 939 246778 5163 6774 6772 6775 2833 8320 604 9021 51176 10219 3398 1788 54790 5027 PMC7381711__F3 Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19) 7018 7035 324 59272 PMC7382314__F7 Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney 920 7124 3280 PMC7382829__F6 KEGG pathway maps represent the NF-ƙB signalling pathway in which DEG in (a) bovine macrophages infected with Nc-Spain1H and (b) Nc-Spain7 versus non-infected macrophages are highlighted 3932 27040 5335 472 29760 1610 613 6850 695 4067 7189 8717 7186 331 7706 3929 929 114609 4513 7099 3553 1270 4803 7187 4049 4050 4055 142 29949 PMC7383016__F1 HR pathway in PTEN-deficient EC cells 1950 1956 5728 4193 10111 4361 545 472 5888 672 675 580 79728 PMC7384889__F4 Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes 7471 1499 4040 4041 PMC7385189__F2 Primary resistance 567 1493 3902 9760 4283 3627 1956 5728 3576 2475 1499 PMC7385902__F3 Correlation plots for genes (absolute Pearson correlation > 0.4) that contributed to the enrichment of MAPK38 pathway in ER negative tumor and phosphocholine synthesis in ER negative normal-adjacent samples 1386 3150 80736 7043 1119 1120 64900 7042 4208 9261 57153 PMC7387981__F1 Cannabinoids' pharmacology 79054 3416 1499 6010 PMC7388725__F1 Ferroptosis in a cell 27165 2729 2937 875 3652 3156 100 2182 10162 55240 8031 7018 PMC7390836__F4 DSGs That Are Driver Genes of the CRC Pathway(A) Mapping of DSGs in the CRC pathway from KEGG 4434 324 4089 4437 2956 4609 387569 572 842 5604 836 387 4436 51426 6654 3265 1950 1956 2475 2078 374 6198 5900 PMC7391667__F3 Direct pathway of m6A to regulate transcriptome a Two possible mechanisms of eIF3 regulating mRNA translation initiation 51441 23269 91746 1999 57721 253943 64848 54915 PMC7395714__F1 Surface expression of PD-1, PD-L1 and CTLA-4 375 4245 9760 987 54918 146223 PMC7396046__F2 Suggested signaling pathway for glucose-induced increase in glucagon synthesis, glucagon secretion, and alpha cell proliferation 2475 1956 6714 PMC7396595__F2 In the absence of co-stimulation, typically in a T lymphocyte that has not been exposed to antigen yet (naive T cell), GSK3B is constitutively active and phosphorylates NFAT2 868 2932 941 942 30009 3558 50943 1499 3586 940 PMC7396666__F2 Mammalian UPR 22926 7494 83939 468 4015 PMC7396796__F1 Model representing the molecular signaling pathway of WAVE3 contributing to cancer progression and metastasis 1950 4087 5879 PMC7397197__F5 Nonautonomous replication stress response in the central nervous system 9447 115004 29110 3661 7124 PMC7397749__F1 Synthesis and metabolism of PUFAs 4018 9415 60481 6295 10162 3992 4099 79143 54898 5091 PMC7397827__F5 Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) 7098 7124 81030 197259 8205 PMC7398104__F5 TGFB1 pathway activation is reduced following RYGB 7040 7124 3606 9475 1437 2305 7709 196 4613 3400 64388 PMC7398379__F5 Proposed model of the transgelin mechanisms involved in promoting colon cancer metastasis 6010 142 7456 801 51517 5879 7454 PMC7399146__F4 Physical exercise actions against aging brain and the apoptotic process 355 8772 4803 627 581 317 PMC7400218__F5 Cervical cancer in low and middle-income countries 4615 5879 3661 7189 7124 7099 PMC7400738__F2 Biogenesis, secretion, composition, and application of exosomes as liquid biopsy 7251 928 967 975 PMC7403995__F7 Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes 7450 27040 695 5336 4067 2534 5879 5266 6850 PMC7405480__F2 The p53 signaling pathway by binding and ubiquitylation of tumor-regulating proteins in GC 4193 286827 23608 64326 PMC7407234__F6 Proposed model for MX1’s role in ERS-mediated cell fate 22926 7494 468 4599 PMC7407311__F7 CXCL14 regulates hESC self-renewal and cell cycle through IGF-1R signaling pathway 9547 3480 6657 79923 983 1021 PMC7407354__F1 Scheme of the amino acid (AA)-related energy metabolic pathway shows the amino acids and their metabolites in the nontumor and tumor regions 5091 5106 5105 2744 PMC7407580__F1 Involvement of the CCL5/CCR5 axis in cancer progression 8205 9242 6352 6355 6351 6348 4313 4318 1234 6774 PMC7407683__F1 FSHR is expressed in multiple organs related to metabolic diseases and FSH/FSHR participates in the regulation of cellular activities and metabolic processes 2492 2475 7350 3949 355 4023 5915 157506 84649 PMC7407683__F2 FSH and obesity 2492 4023 5915 157506 84649 355 PMC7407888__F1 Scheme illustrating the IL-10 signaling pathway 7297 6774 9021 PMC7407959__F1 Surgery and temporal sequence of icv 759 761 6761 4397 PMC7408019__F6 KLF4 acts as a negative regulator of wt-CFTR but has its function disrupted in the F508del–CFTR cells 1080 2932 9531 9314 PMC7408589__F12 Influence of X-rays (7 Gy) on regulation of the p53 pathway (according to the Mus musculus p53 signaling pathway available at https://www.genome.jp/kegg/) in mESCs in presence of LIF (+LIF) and absence of LIF (-LIF) 472 4193 545 3486 5728 64065 7249 64326 6477 842 836 2475 3976 PMC7408826__F2 Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment 90417 1956 2195 4853 4851 2885 54101 1029 4485 5317 9113 26524 5921 1019 4193 4609 PMC7408912__F5 MiRNA regulation of homologous recombination (HR) repair factors after IR 3014 472 5888 675 5893 79728 PMC7408991__F4 Redox homeostasis and metabolic shift through activation of the Nrf2-Keap1 pathway and regulation of the NAD+/NADH ratio by PM redox enzymes 23411 9817 2309 PMC7411855__F3 MAPK and NFKB signaling pathway of ginkgolides in the regulation of IIR 7099 7096 10333 4615 51135 3654 29110 3665 PMC7412275__F2 Entry mechanisms of Old World (OW) and New World (NW) arenaviruses 8828 8411 3916 967 PMC7412635__F7 The dichotomous effects of VCD on follicular development 135935 2661 6194 5728 PMC7412712__F2 Schematic description of TRAIL signaling cascade and interaction of lncRNA 100505881 8772 283131 637 285943 5455 60674 596 638 317 283120 PMC7415428__F12 Schematically drawing the diagraph for illustrating the signaling pathway and pointing the action sites of melatonin 5728 581 143 PMC7416697__F7 ABCC4 function in SHH signaling 2736 51684 6608 5727 2737 6469 2735 PMC7417304__F1 Signaling mechanism and regulation of the Hippo pathway in drosophila and mammals 60485 4485 55233 9113 PMC7417304__F2 Hippo pathway in innate anti-bacterial immunity 4615 4485 51135 7187 29110 3661 3665 51295 5879 7189 PMC7417304__F3 Hippo pathway in innate antiviral immunity 4615 115004 9113 26524 7187 57506 29110 4485 3661 PMC7417632__F7 Hypothetical molecular mechanism of the H19/miR-29a/Wnt signaling pathway in HF inducibility of DP cells 4040 4041 22943 79412 2932 324 1499 6423 283120 PMC7418434__F1 Pathways controlling ferroptosis, necroptosis, and pyroptosis 2879 114548 197259 8737 11035 140609 PMC7418786__F3 Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication 9943 22848 25865 9578 2053 1432 6714 1956 3065 8986 5605 23387 6788 1198 5829 55824 50618 274 1500 54874 29763 6453 85021 2060 8976 8874 4690 9922 2017 29924 2059 5286 867 3267 10006 6654 9146 1211 58513 1601 10617 408 2580 5578 5770 6774 1506 PMC7422534__F4 MicroRNA-target interaction networks 5526 100302164 55844 7534 4908 1399 6722 8911 6464 11186 9344 2353 51347 3562 3688 3908 2149 7529 7531 55970 2261 7424 2247 2254 2885 10369 8074 7157 783 5863 1846 836 PMC7422669__F3 Engulfment of apoptotic tumor cells induces LAP to inhibit type I IFN response and polarize tumor associated macrophages toward the immunosuppressive M2 phenotype 8205 7939 3553 3458 PMC7422850__F4 Anti apoptotic effect of curcumin 8772 581 637 331 PMC7424006__F10 TLR4 had an important proatherogenic role in monocytes/macrophages 7099 114609 4615 7189 3663 7412 3383 PMC7425302__F2 Interferon G signaling pathway 4283 3458 3627 3459 3460 3716 3717 5771 6772 6773 3659 55193 196528 29117 PMC7426447__F2 Signal transduction of ginseng gintonin on the mammalian cell plasma membrane via LPA receptors, GPR40, and GPR55 4018 9290 759 627 PMC7427672__F1 OI genes involved in collagen biosynthesis and maintenance of bone homeostasis 7471 55603 871 10491 90993 649 5352 5358 5176 6678 64175 51360 387733 121340 60681 5053 9871 23184 5479 55151 1277 1278 PMC7427992__F7 TG-resident HSV-specific memory CD8+ TRM cells downregulate the T cell exhaustion associated pathway and confer protection from ocular herpes in HSV-1 infected asymptomatic humans and HLA transgenic rabbits 201633 3902 969 960 2833 1236 7038 PMC7429975__F7 Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models 4149 2669 7054 6608 100187761 PMC7432215__F2 MUDENG Augmentation: A Genesis in Anti-Cancer Therapy? 836 637 842 581 317 8772 PMC7432388__F2 Top two networks based on ingenuity pathway analysis (IPA) showing interactions between the controls and the case 23269 782 6474 9242 860 5308 8022 7157 6622 122042 PMC7432461__F3 Interactions of coronavirus proteins with metabolic pathways 34 2181 51703 23646 2356 10170 5431 5424 3295 5833 64900 9517 79178 23649 5422 5558 5557 5538 80142 224 8540 6241 3615 132 100 1595 7498 22978 79077 290 10380 51079 8733 54480 79586 4715 9550 4705 84720 2590 7841 201595 523 29880 79053 440138 2023 2027 94005 23193 27430 4144 1312 8897 51477 7360 81889 10157 1786 54187 10020 PMC7432832__F3 AhR pathway interactions in cancer breast cells 196 3569 4609 7054 5328 PMC7432853__F2 Different mechanisms of crosstalk between pancreatic ductal adenocarcinoma (PDAC) cancer cells and cancer-associated fibroblasts (CAFs) 207 558 3479 2621 6469 4838 3976 PMC7433406__F8 Neuroprotective Effects of Celastrol on Transient Global Cerebral Ischemia Rats via Regulating HMGB1/NFKB Signaling Pathway 3146 7099 2670 581 3553 PMC7434719__F1 Diagrammatic presentation of conserved domains of MUC2, MUC6, MUC5AC, and MUC5B 4588 4583 4586 727897 PMC7438542__F1 Co-stimulatory signals that enhance MAIT cell activation 3575 29851 149233 6774 PMC7438746__F4 Transcriptional regulation by mTORC1 4094 11201 5465 6774 3091 7942 PMC7439504__F6 Beyond the cell factory: Homeostatic regulation of and by the UPRER 7186 2308 596 PMC7440669__F2 In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli 197257 4199 4200 PMC7441375__F9 Action of MPA 6010 8833 5158 5145 2638 PMC7442613__F1 Topical treatment strategies to manipulate human skin pigmentation 4157 4286 5443 1638 7306 PMC7443478__F9 Sensitization of glutamate receptor‐mediated pain behaviour via nerve growth factor‐dependent phosphorylation of transient receptor potential V1 under inflammatory conditions 4803 7442 9495 PMC7447759__F8 Functional annotation network 488 7170 1356 4633 3708 23764 26999 54331 7134 2273 2353 467 8048 PMC7451686__F1 Working model for mTORC1/p70S6K signaling regulation of Beta-TrCP-mediated PD-L1 degradation 64223 8454 2475 64798 6500 PMC7453310__F3 Alternative splicing regulation of the oncogenic MYC and RAS-MAPK pathways 4609 3178 6426 4149 1956 5879 6732 2872 1977 PMC7453842__F1 Schematic depicting pantothenate uptake and transformation into CoA through the CoA biosynthetic pathway 5471 79717 60490 PMC7456554__F3 Toll-like receptor (TLR) pathways deregulated in systemic sclerosis (SSc) 114609 4118 929 4615 3654 7189 29110 7187 3661 PMC7456869__F5 SARS-CoV-2 in the complement system 727 717 721 718 PMC7457719__F6 Scheme illustration for Au4.5-induced NLRP3 inflammasome activation 4827 10533 9474 114548 3553 PMC7458154__F1 Connections of Metabolic Pathways with PTM Reactions through Intermediate Metabolites and Impact of Growth Factor Signaling on Modulation of Glucose Metabolism 7249 7248 2308 4609 3091 PMC7459525__F6 The possible FDNCR1-miR-204-TGFBR1 pathway in porcine preadipocyte differentiation 7046 4087 4088 PMC7459801__F1 Processing and trafficking of amyloid precursor protein (APP) through the endolysosomal pathway 351 5663 23621 5664 PMC7460084__F1 Schematic presentation of transforming growth factor-beta (TGFB) signaling pathways 4088 4087 2475 4089 PMC7460641__F3a Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop 27159 373073 6476 246744 175 51083 572 PMC7460884__F3 MCSs regulating cholesterol trafficking to the ER 10577 4864 57476 9218 9217 PMC7461616__F1 Targeting lipid metabolism of myeloid cells in cancer immunotherapy 51311 51284 355 54106 729230 958 1493 8205 PMC7462039__F1 Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells 4035 6010 5159 6667 2475 2308 1956 PMC7462746__F6 cGAS-STING Pathway inhibition by HCQ and CQ: DNA sensor cGAS (cyclic GMP-AMP synthase) can recognize DNA of viral/bacterial origin and synthesize a dinucleotide molecule, cGAMP (2′, 5′-cyclic GMP-AMP dinucleotide) 115004 3661 7124 PMC7462863__F6 Genomic landscape of Mongolian hepatocellular carcinoma 5728 2066 23269 4149 5290 2263 3815 5156 4613 6945 57521 4609 7249 1674 5925 898 1499 139285 324 472 6422 6423 7091 7157 4194 213 55629 389524 1301 204 6708 23230 27445 114784 114788 338 5099 79677 11328 PMC7463546__F1 NFKB signaling pathway and anti-multiple myeloma (MM) drug targets 4055 1950 958 1956 7186 7189 7187 7188 5970 5971 PMC7463967__F1 Illustration of the Hippo pathway and its regulation in mammalian cells 1956 4018 4485 9113 26524 60485 PMC7465688__F1 Postulated signaling pathways affecting endothelial progenitor cells (EPCs) 1950 7852 22943 PMC7467536__F2 PRC2-mediated feed-forward control of transcription factors and signaling pathway components can serve as a “dimmer switch” of gene expression changes 1311 7018 8858 PMC7468012__F1 Embryonic MTHFR contributes to blastocyst development 6470 4524 4548 100188776 6472 PMC7469327__F3 Action of the NLRP3 inflammasome 7220 24145 4615 79792 114548 PMC7472464__F7 Overview of metabolic reprogramming in adipose tissue in EgPSC infected mice 2539 730249 95 1431 2271 PMC7477231__F8 Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway 2638 388011 5230 283422 5728 2146 9242 10873 PMC7480187__F7 Alleviation prostate cancer progression via overexpresion of RIP3 197259 890 891 983 PMC7483800__F3 SARM1 Axon Degeneration Pathway: Control of the NAD+ Metabolome Regulates Axon Survival in Health and Disease 93100 203447 10135 23098 PMC7483931__F1 Periodontal disease associated genes and proteins have multiple possible interactions with GM-CSF and TSLP 6387 1606 10673 8741 8372 23553 5743 10631 54959 PMC7484971__F8 KEGG enrichment graph: miRNA-4534 is involved in the FOXO signaling pathway 4089 4088 51701 6502 4193 664 9140 5728 3643 472 7874 57120 6774 1017 3586 5966 3575 10365 1950 1956 PMC7485387__F3 FGF23 signaling in the kidney 8074 2260 1958 1591 1594 56302 PMC7486775__F1 Candidate pathways supporting phosphoglycolate salvage in C 5160 5161 5162 10296 321 717 PMC7487981__F1 Local area (subpathway) of retinol metabolism pathway is highly correlated with ALDH1A1 10901 8228 9227 7364 PMC7488177__F2 Potential role of LRG1 in abnormal angiogenesis of diabetic nephropathy associated with TGFB1 signaling pathway 116844 4087 4088 4086 4090 PMC7489527__F6 Anti-neuroinflammatory effects of Clinacanthus nutans leaf extract on metabolism elucidated through 1H NMR in correlation with cytokines microarray 3603 3458 3565 PMC7489940__F5 PI3K-AKT signing pathway 54541 412 1977 7249 6009 2475 1975 57521 6194 5578 29941 4846 2885 3265 7097 117145 2932 3492 6850 5290 4609 930 1017 1440 1441 5747 2309 5934 11140 5728 200186 10971 356 23035 572 596 10161 146850 842 10488 6256 1147 4602 4193 PMC7490227__F10 Silencing of S100A4 downregulated the PI3K/Akt/mTOR pathway, enhanced autophagy, and promoted wound healing of rabbit cornea after alkali burn 2248 2475 23192 PMC7492540__F1 Schematic of known pathways regulated by AR in various breast cancer subtypes 7477 1499 3169 4609 367 6659 5728 116435288 PMC7492732__F1 Biosynthesis of kinamycin 249 248 9049 PMC7493839__F3 Application of CRISPR-Cas9 in construction of TCR and CAR T-cells 3902 28755 1493 355 59067 567 PMC7495247__F1 A) Schematic showing how COVID-19 triggers hyper-activation of the immune-response, generating a cytokine storm 4513 4512 717 4050 PMC7500163__F1 Pathways expressed during humoral immune response of SARS-CoV-2 infection 100187761 4318 923 5155 4254 4792 468 7706 8837 4193 7424 7157 7422 PMC7501671__F8 EMfC action in amelioration of inflammatory response and autophagy pathway during anti-hepatic steatosis in HFD-induced obesity mice 83939 468 10533 9140 355 2475 PMC7502316__F3 Alterations of Spermatozoa Proteomic Profile in Men with Hodgkin's Disease Prior to Cancer Therapy 1636 49 6950 7203 10575 136242 5646 10574 908 PMC7503462__F1 Schematic description of tryptophan metabolic pathways with assigned physiological roles and regulatory points of select metabolites 438 3553 169355 8942 8564 PMC7503766__F7 Nodulation (NOD)-like receptor signaling pathway (PM vs 351 100187907 5185 10010 3492 9118 8139 PMC7503842__F2 Aberrant Wnt signaling favors disease progression in leukemia 9242 1000 652 2475 2305 3732 6495 939 970 8313 4513 PMC7505148__F5 CORM-A1 on glycolysis and pentose phosphate pathway (PPP) metabolites in platelets 5209 2147 2597 3939 PMC7505271__F2 Relationships between mitochondrial and serotoninergic dysfunctions 2932 718 735 PMC7505271__F4 Relationships between mitochondrial and norepinephrine dysfunctions 718 735 1621 217 PMC7510352__F1 Families of PDGF/PDGFR and the downstream signalling pathways 5155 56034 80310 2885 6774 572 4313 598 4086 7422 4609 PMC7516048__F2 Model for B. pertussis CyaA regulated complex signaling pathways to block the monocyte differentiation and to trigger macrophage dedifferentiation 387 9113 26524 PMC7518150__F5 Molecular mechanism of Wnt/Beta-catenin signaling pathway activation 324 4040 4041 1499 2932 PMC7519200__F3 Innate immune system is the first line of defense against infection and injury and plays critical roles in the maintenance of brain homeostasis 114548 23411 3603 PMC7519530__F6 Hypothesized role of miR-142-5p and miR-365a-3p in CML signaling 27 2885 6717 581 842 2475 572 4170 PMC7519685__F4 Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? 7124 355 596 581 PMC7520270__F5 Enrichment and functional annotation by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) 54843 2495 4513 2512 27347 302 10551 10945 23568 1605 6809 6624 1969 301 130271 822 9837 1107 7316 4173 5889 7429 23443 1381 4891 201266 1382 2026 5214 501 3157 7915 PMC7520847__F1 RAS signaling pathway 5728 2885 5163 7249 7248 6009 2002 3667 PMC7521272__F4 Pathway analysis of the differentially expressed proteins between the gastric cancer (T) and adjacent tissues (P) 100187761 4538 4541 4692 6389 6390 6391 6392 4519 1352 10063 6476 126328 4726 7388 7386 4705 4713 4700 4718 7385 4696 27089 4722 4715 4706 55967 PMC7521313__F3 Danshen is shown to regulate the TLR signalling pathway 6696 7097 942 5602 941 5293 3627 5603 51311 3663 54106 7099 5879 54472 100187907 3569 8772 3929 3565 929 23118 114609 2444 5066 920 1513 3550 PMC7521521__F1 Cullin-RING E3 ligases (CRLs) and the NEDD8 conjugation pathway 6500 1642 9978 8454 26259 PMC7521960__F2 COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis 3932 7535 27040 472 8517 29760 613 4067 4615 8915 10892 3553 3654 7189 7186 7188 331 1540 1896 10913 4791 1147 7187 4792 4790 5743 3929 929 29949 114609 6351 7412 7099 51179 4803 5328 959 958 4049 4050 6357 4055 6387 3383 3661 7098 51284 51311 54106 PMC7522371__F4 TGFB signaling pathway 7048 7046 4087 4088 4089 PMC7522570__F8 Expression of orthologs annotated for the Kyoto Encyclopedia of Genes and Genomes (KEGG) glycolysis and gluconeogenesis (ko00010) pathway present in pleural ventral caudal sensory neuron (PVC) expression clusters with decreasing trend (P4 and P5) 5236 3098 83440 2645 130589 2821 5211 2203 226 7167 2597 669 5230 441531 9562 2023 5105 5313 5160 1737 55902 1738 124 10327 PMC7522570__F9 Expression of orthologs annotated for the Kyoto Encyclopedia of Genes and Genomes (KEGG) tricarboxylic acid cycle (ko00020) pathway present in pleural ventral caudal sensory neuron (PVC) expression clusters with decreasing trend (P4 and P5) 5105 1737 5160 1738 5091 1431 47 4190 2271 3419 6389 8801 1743 4967 PMC7530066__F9 Insulin-like growth factor 1-Receptor signaling stimulates GRP78 expression through the PI3K/AKT/mTOR/ATF4 axis 3479 3480 2475 468 PMC7530341__F6 Proposed gestational age-dependent changes in placental TRP metabolic pathways 15 438 6581 6532 1644 5805 6697 883 8140 6520 23428 8942 23475 PMC7530368__F2 Mitochondrial dysfunction in kidney injury, inflammation, and disease: potential therapeutic approaches 50507 11035 8011 115004 3458 3553 PMC7531038__F6 Possible intracellular signaling pathways activated in chondrocytes upon treatment with pararama hair extract 718 7045 960 7097 7099 10454 4089 4087 4792 6416 6667 4312 6347 58191 7422 3569 PMC7533107__F1 TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation 847 7226 7099 114548 3553 3576 140609 79792 PMC7537965__F4 A venn diagram showing overlaps between BCG genetic mimics and key hubs with SARS-CoV-2 and Corona viruses interactomes 5566 23408 1975 23429 26986 4758 949 3162 1460 23476 9360 11113 5327 10280 22809 2150 3482 5664 819 8737 598 4698 23564 2782 5478 4722 857 8836 3458 920 64806 6352 PMC7539765__F5 Probable interactions among TRIP13 and other molecules within clear cell Renal Cell Carcinoma 9319 91875 3280 999 2475 4088 PMC7539774__F6 Schematic diagram of HP-based regulation in breast cancer glycolytic signaling pathway 3098 2821 5214 5315 5163 3939 PMC7539786__F6 Scheme showing the activation of the STING pathway by cytosolic DNA and regulation by metformin 115004 3661 29110 207 PMC7542154__F3 Immunoregulation of PD-L1/PD-1 in GBC 2064 1956 2065 2475 PMC7544845__F5 NOTCH signaling pathway in giant cell arteritis 920 4851 940 3280 PMC7547073__F2 MicroRNA-34a targets the colorectal cancer pathway 7043 1630 7048 3845 842 4089 5290 369 5900 836 208 5604 5880 596 1499 572 8313 54205 51176 4609 3725 2353 595 7157 PMC7549352__F1 miRNA biogenesis: the canonical pathway begins with the transcription of miRNA genes to form the pri-miRNA 9924 255967 2000 29102 54487 PMC7550403__F1 Pathways of complement activation with complement regulators and inhibitors highlighted 1356 718 720 721 1604 4179 2271 727 966 7448 PMC7551725__F2 Tryptophan (Trp) metabolism and AhR pathway in health and disease 196 3620 6774 PMC7554122__F3 TGFB2-Hepcidin feed-forward loop 57817 7042 7048 7046 PMC7554788__F1 Action of CDK4/6 inhibitors 2475 1021 1019 PMC7555106__F3 MDSC-mediated events in intestinal epithelial dysplasia 6279 1499 4609 1901 PMC7555983__F6 MiRNAs, their related gene targets and cellular pathways likely involved in MFS aortopathy 324 999 890 PMC7557148__F2 Some key events during early embryogenesis in Arabidopsis 5300 381 4149 PMC7559172__F7 Wnt signaling pathway enriched in KEGG 51701 147111 9350 1499 324 4089 4088 25805 50964 6500 8454 6477 2040 23002 387 9475 27130 6259 PMC7559772__F2 Genetic regulation of cell fate and size of the progenitor zone 4846 1017 7166 PMC7559774__F3 tRF-Leu-CAG, ts-101, ts-46, and ts-47 are involved in drug resistance of lung cancer cells 5728 6790 3611 3845 6714 2932 595 5899 2475 PMC7563696__F3 Rho GTPases in spine morphogenesis 998 5879 3984 5058 387 PMC7563796__F1 Multiple functions of microglia and macrophages in brain injury 6347 4240 4345 PMC7564431__F6 STRING protein interaction network of 61 out of 652 genes targeted by the selected miRNAs and directly involved in the breast cancer KEGG pathway (hsa05224) 7477 7479 7483 2246 2247 2254 4853 4854 89780 7474 1956 4851 2064 2260 3480 8325 8503 5290 8323 7855 2885 5728 5291 6655 7976 2535 3265 3845 207 208 10000 1857 5894 673 369 6198 6199 2932 324 1499 8202 3725 2353 4609 595 7157 6934 5925 1021 1019 1643 1869 1871 1026 581 1647 PMC7565128__F2 Crosstalk between Hh signaling pathway and PI3K/AKT/mTOR pathway, Wnt/Beta-catenin pathway, Notch pathway 6469 1499 324 2475 2735 6662 3725 5727 6608 4040 4041 PMC7565917__F4 Hypothetical steps leading to the disassembly of NETs 7450 1776 7099 4615 54106 29121 11277 PMC7566002__F9 A possible molecular network between RASSF1A, the Hippo pathway effector YAP1, AKT, FOXO3A, FOXM1, and ERA based on the findings in this paper and on the published literature 1019 1021 983 1017 5347 2305 10413 PMC7567008__F3 Crosstalk between Toll-like-receptor (TLR) signaling and the Hippo pathway in Drosophila and mammalian cells 4615 7187 4485 51135 29110 51295 3661 7189 PMC7567033__F1 Scheme of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in the regulation of autophagy process 1956 4763 5728 5163 7248 7249 7157 6009 8408 9776 60673 64798 1978 55626 7405 22863 PMC7567953__F2 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics 1901 9294 718 387 207 4090 4086 4089 1499 860 PMC7568652__F3 CD40 pathway genes upregulated (red) or downregulated (green) by exposure of primary human keratinocytes to TSST-1 (100 μg/ml) or SEB (100 μg/ml) in triplicate assays for 6 h exposure time 958 7185 7189 7188 10010 7187 466 PMC7570423__F1 Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 5478 7113 59272 PMC7570423__F3 Immunity, endothelial injury and complement-induced coagulopathy in COVID-19 59272 7113 7450 729 730 735 367 PMC7572318__F3 RIPLET is an essential E3 ligase for RIG-I signaling pathway 1283 57506 29110 3661 PMC7574311__F3 Leaf-specific DEG attributed to photosynthesis are enhanced in SPL13RNAi plants 4693 5091 445 PMC7574648__F7 Model summarizing the functional relationship between Rab5-Rab11 GTPases and BDNF/TrkB-mediated CREB transcriptional regulation 627 2475 1958 1843 23237 PMC7576031__F3 Protein tyrosine phosphatase receptor type D (PTPRD)—mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review 2475 6774 5789 7535 27040 PMC7576355__F1 Androgen regulation of cell cycle and CDK4/6 pathway 367 2475 6714 7018 2002 PMC7576355__F3 Speckle-type POZ protein (SPOP) and CDK4/6 pathway 1019 595 1021 8405 PMC7576355__F5 FGFR axis, Ras-Raf-MEK and TP53 relationship to CDK4/6; FGFR results in activation of PI3K, Ras-Raf-MEK, STAT which increases cyclin D1, thereby promoting progression through the cell cycle 7157 4193 1019 1017 PMC7576823__F3 Talin1 plays significant roles in cancer related pathway 214 6714 3611 3725 6010 2475 1499 PMC7578566__F3 Cellular senescence by extracellular matrix during chronic fibrotic diseases 3491 10682 5879 324 4089 1499 4087 4088 7157 3486 PMC7580701__F1 Effect of environmental pollution on immune evasion checkpoints of SARS-CoV-2 7113 196 59272 3458 3620 50943 6774 PMC7583981__F1 Pyroptosis canonical pathway and non-canonical pathway 9447 58484 114548 79792 PMC7583981__F2 Oxidative stress and ER stress in inflammation in DKD 50507 10628 3553 114548 PMC7585830__F3 Positive and negative regulation of Hp (HAMP) transcription and systemic iron homeostasis through the Hp/Fpn signaling pathway 3240 654 148738 6774 3717 3250 4089 3258 151176 5447 2056 PMC7585830__F4 Altered iron homeostasis in breast Cancer Cells and the contribution of their microenvironment 3569 148738 3717 3570 6774 3458 4089 1901 23410 3240 22933 PMC7586431__F5 Statin therapy for cancer 836 2475 3845 387 7018 PMC7586926__F1 SARS-CoV-2 pathogenesis 59272 7113 1514 PMC7590211__F3 Opposing modulatory effects of TRIM25 and TRIM47 on TGFBeta-Smad signaling in the GI tract 7706 4087 5163 9830 5728 2932 4089 5987 91107 54765 2475 PMC7590238__F1 ICL repair pathway at different cell cycle phases 7508 7507 51455 55215 2177 84464 22909 80198 146956 PMC7590701__F6 Network analysis and hypothetical model construction 2263 9314 2314 6774 652 7044 960 3213 83700 6007 60 861 PMC7593679__F1 TRP and its key catabolites (TRYCATs) produced via three biochemical pathways: the kynurenine pathway, tryptamine pathway, and serotonin pathway 7166 3620 169355 6999 8564 PMC7595309__F2 Dual-function quorum-sensing systems in bacterial pathogens and symbionts 1356 846 157739 6855 PMC7599540__F4 Src Homology Region 2 Domain-Containing Phosphatase-2 (SHP-2) targeting on melanoma cells 1950 3082 3466 PMC7600636__F2 Canonical pathway of STAT3 signaling 6774 9021 6714 PMC7600793__F6 Scheme of N9 microglia NF-kB, NFAT, MAPK, and IL-10/STAT3 inflammatory pathways modulated by 2J19 GIB fraction 958 3716 6774 PMC7601648__F1 Canonical NFKB signalling pathway induced by TNFA and IL-1B and the role of ubiquitination 84196 6478 57478 7186 8717 4615 3654 51135 83737 26994 7189 8887 1540 7375 9825 7874 373 10868 55611 51147 8651 27005 64236 PMC7602614__F3 STAT3 regulates the transcription of gene sets involved in cancer development 1244 368 7422 3082 6774 4312 6657 79923 7291 PMC7606751__F1 Role of BCAA metabolism in cancer progression 27040 54790 4211 152926 593 10295 6714 PMC7607069__F14 PPI network of TP53 signaling pathway genes (GeneMANIA) 6135 5930 64750 64067 9656 7319 6125 7157 4194 5824 207 4193 7158 51741 23113 7161 55602 56906 8178 PMC7611845__F1 Driver pathways in the pathogenesis of marginal zone lymphoma 4853 4615 51135 3654 7189 84433 10892 8915 613 6850 695 29760 930 4067 2475 PMC7644914__F1 The underlying molecular mechanisms influencing the protein synthesis, degradation, and dynamic trafficking processes of ASIC1a 3553 4803 627 PMC7645269__F8 Fibrogenesis during skeletal muscle atrophy 4087 4088 9618 5163 50507 PMC7646947__F1 Molecules and signaling pathways involved in muscle protein synthesis and degradation 3479 3480 6774 2475 PMC7648688__F8 Network of potential core targets and signaling pathways in the treatment of IS by AT 5054 5465 7124 4780 2149 5294 4314 65057 5468 2147 5879 4313 2152 3725 3553 5319 5327 5320 7422 4846 5583 4312 4843 5742 5743 2168 4318 9536 5290 4353 PMC7650600__F8 KIR2DL2/L3/S2+ CD8+ T cell cluster analysis of the protein-protein interaction (PPI) network with STRING database 3803 8148 3134 7704 6468 404672 112 3105 3115 3437 29922 965 3665 26270 7323 1230 2214 3458 6348 8021 1789 51744 5551 4089 960 7133 8669 1232 90 6229 6139 3784 5604 7046 1956 6129 864 1026 6232 5962 3748 7454 25873 2309 942 6159 11224 6173 6167 6189 PMC7653364__F4 Dysregulation of A-to-I RNA editing promotes cancer progression 1719 2556 3490 2735 PMC7653638__F5 FGFR1 and KLB effect on endocrine vs canonical FGF signaling 26291 2247 2260 152831 PMC7655095__F7 The Gb3‐cSrc correlated mutant p53 signaling pathways 2669 1499 56339 6426 PMC7658045__F7 Distinct cation gradients power cholesterol transport at different key points in the Hedgehog signaling pathway 6608 5727 6469 57758 84976 PMC7658606__F6 Diagram showing the mechanism of Tanshinone IIA on EMT and metastasis in colorectal cancer 2932 324 1499 1000 PMC7658718__F7 Schematic model illustatrating the redox regulation of PD-L1 expression through growth factor signaling 1950 2246 1956 2260 PMC7661798__F4 Cellular response to growth factor (GF) via its receptor 5290 2475 5728 PMC7662373__F1 The hypoxia pathway under normoxia and hypoxia 7428 6774 7018 PMC7663714__F2 Interplay between different proangiogenic factors and their corresponding modulatory microRNAs 7422 2247 10818 3717 6774 5281 5155 406900 4318 4313 4316 4312 PMC7664196__F2 Apoptosis and Calcium (Ca2+) dynamics in cancer 355 8772 331 4170 637 317 581 90550 5728 5371 8314 25827 PMC7664196__F3 Autophagy, Ca2+ and cancer 84876 6786 2475 9776 8678 22863 55054 PMC7666735__F8 Mechanisms contributing to RES inhibiting the metastatic potential of cervical cancer cells 999 3716 4314 4322 6774 7291 1000 PMC7667664__F3 Efferocytosis in health and disease 920 961 2621 558 4513 4035 10048 PMC7670427__F3 EIF2 pathway overlay with the experimental data, AD detection and molecules activation prediction (MAP) 83939 50507 467 595 3178 PMC7670868__F1 Outline of major DNA DSB repair pathway and its relationship with host anti-tumor immune response 3659 472 545 1119 1017 983 PMC7672342__F3 Tuberous sclerosis: a review of the past, present, and future 7248 7249 51256 6009 64223 64798 PMC7676935__F2 Summary of the possible signaling pathway between gut microbiota-bile acids axis and IBS-D 8213 7421 4803 PMC7677403__F4 Inflammasome-mediated signal transduction pathway 920 7098 114548 3428 9447 834 3661 3665 PMC7680500__F2 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine 128 2821 3945 3939 2023 2597 5214 5315 PMC7680500__F6 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine 1356 718 717 6794 23456 100187761 1956 266710 5728 828 PMC7681076__F6 Pexophagy in yeast and mammals 91452 5195 5828 8504 84749 472 4077 5193 5830 55670 5190 5189 7249 PMC7683158__F1 SUMOylation pathway 1499 4193 4609 5728 672 PMC7683515__F2 Signaling pathways up and downstream of mTOR complexes 2885 5163 5894 6776 6777 7249 7248 6009 8320 PMC7687005__F8 Mechanistic diagrams indicate that in osteoporosis, miR‐497 could promote osteoblast proliferation and collagen synthesis, and inhibit osteoblast apoptosis through inhibiting LRG1 and activating TGF‐B1/Smads signalling pathway 116844 4092 4087 4088 4089 PMC7687681__F7 Indirect regulatory functions of miR-128-3p on FOXO4 23411 4884 4303 PMC7688141__F8 Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway 5634 6657 79923 9314 PMC7688371__F1 Oxidative Stress, Folate Receptor Autoimmunity, and CSF Findings in Severe Infantile Autism 875 4524 7054 121278 PMC7690210__F1 Activation pathways of the complement system 718 5648 10747 717 720 727 729 735 PMC7690676__F2 Competing endogenous RNA (ceRNA) mechanisms and potential downstream regulatory mechanisms of NNT-AS1 5420 607 1499 999 595 118856 619501 10533 1021 1869 PMC7690798__F2 Functional interaction network and molecular classes of the 20 genes with high RNAi efficacy from 6167 8662 3646 6129 9045 6632 23367 5441 6125 2064 5901 6210 1938 1499 23020 7015 10992 7157 9184 1956 10713 5691 9978 3329 414059 6301 9361 3336 PMC7691587__F3 The mechanisms regulated by CMTMs in Hepatocellular Carcinoma 1950 116173 123920 146225 1956 112616 1233 54918 3082 152189 6774 4609 1019 596 4318 4313 999 1000 572 619501 PMC7692354__F1 Near-infrared (NIR)-triggered photothermal action in MDA-MB-231 and MCF7 cell lines: the illustration shows irinotecan hydrochloride (IT) on-demand release from irinotecan-loaded biotinylated carbon nanodots (CDs-PEG-BT/IT) by means of hyperthermia 4827 8717 7186 9618 7188 7187 1540 8678 8772 317 8737 10533 9474 64422 840 11035 197259 PMC7692401__F1 Autophagy–lysosomal–endosomal system and the Parkinson’s disease (PD)-related proteins 120892 23317 55737 9829 54832 8867 1509 84286 23400 6609 950 7345 5071 25793 65018 PMC7692959__F3 XIAP Signaling Pathways in Human Cancer 1956 331 1869 10454 23118 100422909 4313 2521 6667 PMC7693401__F4 Molecular events involved in the response of MCs to mediators produced by cell damage and stress 3146 90865 7099 6761 3091 4615 2534 7124 PMC7696540__F4 Downstream signaling of EGFR and other receptor tyrosine kinases [,,] 1956 2322 2475 PMC7696686__F6 The current working hypothesis 4976 65018 4313 6010 5879 PMC7696687__F2 Salvage (rescue) pathway remains a predominant pathway to meet NAD+ cellular requirements 10135 952 406 PMC7697007__F6 TRIP12, ARF, and P53 pathway 8717 9320 4193 PMC7697007__F7 TRIP12 in the DNA damage repair (DDR) pathway in response to DNA double-strand break (DSB) [,,,,,,] 9320 472 9025 165918 7874 672 PMC7698326__F1 GWAS of fibrosing disorders 7515 91039 56852 64478 4734 51422 3662 919 55024 7015 6689 2646 7132 5055 7369 22806 3575 3654 6775 7012 859 5054 11214 3595 4049 3557 1601 9474 4790 4312 1490 57514 643 23765 7124 1832 7040 23308 3663 941 4643 6781 3569 727897 1493 9966 4647 64072 64127 4157 3594 3592 1285 54472 PMC7699248__F1 Mechanisms by which 1,25(OH)2D3 interferes the Wnt/Beta-catenin signaling pathway in human CRC cells 7421 3553 999 22943 1499 8312 2932 6934 6925 595 PMC7699474__F3 Protein interaction networks (PPIs) for ploidy associated c-MYC -interacting bivalent genes 4609 4922 706 367 23464 29760 PMC7699867__F2 Regulation between actin cytoskeleton and Yap/Yorkie at the apical cell cortex in Drosophila and in mammalian cells 9411 81788 7204 PMC7700034__F7 Schematic outline representing the acute effect of AB (1-42) on cholesterol dyshomeostasis-induced neurotoxicity and its possible protection through quinovic acid 3156 23621 9817 836 581 6855 2670 3553 PMC7701249__F2 Iron metabolism-related pathway in ferroptosis 7018 5094 8031 PMC7707178__F2 Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous 3652 4598 4597 PMC7708490__F7 Proposed mechanistic scheme: MELK is critical for metastasis, mitotic progression, and programmed death of LUAD 9833 5347 7291 995 999 4316 1000 983 PMC7709628__F2 Specific nutrients and dietary manipulations affecting insulin/insulin-like growth factor signaling (IIS) pathway 3630 3479 3643 26291 2475 PMC7710361__F5 Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders 18 8639 8942 PMC7712090__F2 Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment 3572 2885 3725 5604 3570 3569 2353 6654 2002 5781 5894 3716 3265 3717 6722 6774 1457 PMC7716408__F6 Proposed molecular mechanisms for PA regulating ferroptosis in IRI-AKI 2879 6520 23657 PMC7716495__F3 Graphic overview of Wnt/Beta-catenin signaling pathway targeted interventions in cancer studies 2932 64840 1499 4512 4513 717 PMC7717145__F1 Disease-based pathway analysis of genes involved in the pathogenesis of lung diseases and respiratory failure 4153 3567 5728 6440 59272 2294 7080 1080 1636 7099 7124 1437 11171 PMC7718402__F6 Neutrophil signaling during resolution of inflammation 355 8772 581 PMC7719100__F2 Molecular mechanism of adipogenesis 652 1499 4086 1879 PMC7719781__F5 Mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) regulates ER stress and insulin signaling 9927 9217 22926 PMC7720622__F2 Estrogen signaling pathway with altered proteins in pterygium tear proteome in highlight 9166 596 3860 1509 7031 5241 7039 1839 7018 1956 2885 PMC7723774__F1 Preparation of the chitosan/sodium alginate (CA/SA) hydrogel simultaneously loaded with parathyroid hormone fragment PTH(1–34) and nano-hydroxyapatite for promoting cranial bone regeneration via the Notch signaling pathway 5741 650 860 388585 3280 PMC7723971__F1 ROS/NLRP3 signaling pathway participates in sepsis-related immune responses 114548 7099 3553 PMC7726150__F6 How Lrp6-APEX2 may interact with the ESCRT machinery and TFG in multivesicular body formation during Wnt-induced endocytosis 10342 27301 5828 4040 PMC7728369__F7 Proposed model illustrating mechanisms of USP39 regulating the proliferation, apoptosis and metastasis of non-small lung cancer cells via regulating the p53 pathway 10713 4313 4318 PMC7728999__F4 LncRNA XLOC_221242 regulates the expression of DNER, which is the key factor of Notch signal pathway 92737 6500 1499 3516 1000 PMC7729528__F1 One‐carbon metabolic pathway 6948 4548 4522 4524 4552 PMC7730574__F5 Anti-inflammatory activity of Ep-ME when targeting TAK1 in the AP-1 signaling pathway 7097 7099 7098 4615 51135 3654 3725 PMC7730716__F1 Schematic image of TGFB/SMAD and BMP/SMAD signaling pathway in fibrosis (upper left box, signal activation via TGFB receptor and ligand attachment; orange and yellow circles/arrows, TGFB ligands/signaling and BMP ligands/signaling, respectively) 4087 4088 4090 4086 4089 PMC7730716__F2 Therapeutic target sites in the TGFB/BMP signaling pathway 7939 4090 4086 4087 4088 4089 PMC7734207__F2 Schematic diagram of the regulation of mitochondrial apoptosis, Wnt/Beta-catenin, JAK-STAT, and PI3K/AKT signaling pathways via different miRNAs in various human cancers 3459 3460 8322 10023 3717 406996 324 1499 7248 7249 317 9021 6009 2305 572 581 595 6774 6925 6772 PMC7735419__F4 Image of the potential transcription factors of GPX8 6929 6925 55628 4150 654254 493869 466 1044 3665 3662 6689 6736 54345 6666 64321 85508 83482 6304 1406 1960 2002 2296 3090 PMC7736111__F2 Molecular and signaling pathway implicated in host cell antiviral response 59272 7706 7186 57506 7187 8717 29110 7189 7188 3661 3665 PMC7736127__F1 Neuronal insulin signaling and brain structure in non-demented older adults: The ARIC Study 3479 2932 3667 PMC7737291__F1 Genes found altered in Central Carbon Metabolism (CCM) pathway in gingivo-buccal oral cancer 11113 2717 5741 8544 PMC7738566__F3 Enhancer effects in establishing cancer signaling environments 9817 8452 5728 1956 2064 2065 2066 5156 2260 2263 2261 2264 3815 3480 8821 6098 4915 4914 4916 5979 238 2322 3717 207 5518 867 54206 25 6654 4763 5921 6794 6009 5781 6016 253260 57521 2475 7048 7046 91 92 369 5894 673 5879 5594 5605 5604 4088 4087 4193 4194 4089 1029 472 11197 4609 6423 6422 6425 6424 11200 4613 4610 54894 84133 27121 22943 27123 27122 4149 8313 8312 23269 2932 1499 324 6932 83463 10608 4084 4601 4335 1026 1027 1030 1031 7089 7090 7091 7088 83439 898 5925 6945 595 894 896 1869 9344 51347 57551 22877 1017 1021 1019 8642 54798 2196 120114 79633 2195 60485 6788 6789 4771 9113 55233 23286 3714 92714 55294 8454 10413 5784 55534 8850 23418 286204 1454 1453 2033 1387 27255 8463 92737 5664 23013 9611 9612 5927 PMC7738607__F2 Skin immune response in dermatophytosis 7124 23765 1956 1950 149233 6850 64170 114548 6774 3553 2919 3576 3458 PMC7738619__F1 Summary of the epigenetic regulation of the GSC phenotype 5978 100124700 55000 23028 4200 10873 9055 4751 1786 55904 8805 6774 PMC7738833__F8 Hypothetical model illustrating that ALKAL1 plays an important role in colorectal cancer migration and invasion via activating SHH signaling pathway 389658 5727 6469 6608 51684 2735 3984 6093 4314 3092 4318 PMC7739562__F7 Diminished canonical Beta-catenin signaling during osteoblast differentiation contributes to osteopenia in progeria 1499 51176 860 2932 324 PMC7744297__F2 AChR clustering and dispersal pathways 4038 4593 285489 1398 1399 1020 PMC7744575__F6 Schematic diagram illustrating the role of proteins encoded DEGs and DASGs and others on AMPA-receptor signaling and synaptic plasticity 9066 8775 6543 PMC7744622__F4 Roles of p53 and PTEN signaling pathways in the regulation of autophagy 5728 7249 7248 2475 64223 6009 10533 8408 9776 60673 55626 22863 1612 4131 57103 PMC7749093__F1 Cardiovascular molecular imaging 2191 729230 7852 6752 706 PMC7750537__F2 Autophagic pathway 29949 7450 60673 9776 596 22863 9140 9474 10533 64422 83734 PMC7751853__F6 Bergenin protects pancreatic beta cells against cytokine-induced apoptosis in INS-1E cells 3553 8772 6772 3717 PMC7753186__F2 Mechanisms involved in SARS-CoV-2 infection delineating an ACE/ACE2-ATR1-Cholesterol-HDAC axis 59272 1636 3569 PMC7754042__F7 miR‐218 could inhibit OSCC proliferation, migration, invasion, EMT and liver metastasis through the TGF‐B signalling pathway by regulating GREM1 4089 26585 999 PMC7755476__F9 Protein-protein interaction network of E2F coexpression genes (GeneMANIA) 29100 6920 23450 2582 7039 6117 6118 79767 641 83461 8317 1894 1871 79019 55165 27338 3399 4087 24137 10772 6420 8996 4602 PMC7755476__F11 Cell cycle and (b) TGF-beta-signaling pathway regulated by the E2F alteration in brain and CNS cancer 9126 5885 4087 4088 4193 6502 5111 1019 1017 1022 324 924 4999 23594 148738 25980 56963 650 3458 1616 387 25805 10468 4838 5308 PMC7756118__F6 The signaling pathway involving in megakaryocytic differentiation in normal and leukemic marrow 558 1788 4869 PMC7756126__F5 Usage of lymphoma B-cell receptor (BCR) antigens for targeting lymphoma 613 8178 201191 940 PMC7757414__F1 Targeted therapies available and in development in Acute Myeloid Leukemia (AML) 4846 6608 3654 51135 7006 100124696 2475 945 1025 596 3417 2146 54880 7157 1788 7514 3556 2322 3815 3717 7852 PMC7758911__F1 RTKs and ERA36 in the development of tamoxifen resistance 6347 1956 8205 5062 2475 PMC7759744__F1 Mitochondrial dynamics and bioenergetics in inflammatory astrocytes and neurological disorders 5164 4976 9927 1020 PMC7760945__F3 Intra-articular (IA) delivery of cargo-loaded nanoparticles for the treatment of OA 3553 9510 3606 PMC7761500__F2 Various tumor-promoting mechanisms that can be exploited in combination with immune checkpoint inhibition 3458 3717 5163 7291 8178 6774 3579 3577 PMC7761568__F2 Influence network of TCR signalling 1493 941 940 920 2885 27040 3902 29851 5728 7528 201633 10666 50943 3458 4092 4087 4094 246778 639 6774 4783 3558 6775 PMC7761926__F2 Wnt targeting agents for the Wnt/Beta-catenin signaling pathway 64840 147111 11197 8549 9350 4040 4041 84133 54894 8658 1499 2932 23043 324 PMC7762141__F2 Host immune response against P 1431 7097 114609 4615 10392 54106 3553 3661 1233 1235 PMC7762355__F1 Inflammatory regulation mechanism in a TREM1/2-TLR4-dependent manner in the liver 7099 54209 54210 4615 51135 6714 3654 6850 7189 64170 929 PMC7762936__F2 Post-translational regulation of the long and winding cholesterol synthesis pathway 39 3156 153830 4598 10654 3930 10299 4597 50814 51478 3422 91734 1718 2224 10682 6309 1717 4047 PMC7764352__F7 STRING: AML associated enriched pathways among the top 94 identified drug targets 7375 3921 50964 7037 5426 PMC7766850__F8 Scheme of the effects of AMPAR antagonists on spontaneous seizure activity in epilepsy rats based on a previous and the present studies 6714 5728 1020 PMC7767049__F2 Administration of Beta-AR blockade can enhance the efficacy of RT by modulation of tumor microenvironment in irradiated and non-irradiated tumors 27076 3099 3458 3002 4283 3627 2833 PMC7767648__F4 Suppression of ARID1A associated with decreased CD8 T cells improves cell survival of ovarian clear cell carcinoma 3691 89 88 7070 10891 3084 6159 7422 100188776 8289 367 4851 50861 4763 4627 5921 6233 60488 1384 6188 2332 PMC7767850__F3 PD-1/PD-L1/PD-L2 pathway hijacking in oncology 941 942 940 3458 2774 PMC7767850__F4 Immune escape through PD-1/PD-L1 pathway in B-cell malignancies 324 8205 941 942 940 3458 920 567 PMC7768045__F4 Intramembrane proteolysis in cancer related signaling 102 6868 23770 2066 PMC7768751__F1 Role of Diet and Phospholipase D enzyme in the complex network of choline pathways and Choline-Mediated 1C metabolism 10400 5091 4144 PMC7769821__F4 KEGG pathway schematic diagram of inflammatory bowel disease (IBD) 3562 324 3565 3976 PMC7772020__F1 Central metabolic regulation of ferroptosis 7012 100 6713 PMC7772395__F2 This figure displays a suggested relationship between coagulation and inflammation in patients with a SARS-CoV-2-infection 7113 5340 7018 3552 324 5091 PMC7773221__F2 Common regulatory proteins of the complement and coagulation systems 324 715 721 716 5648 10747 PMC7773645__F1 NLRP3 inflammasome pathway associated with potential blockade sites of various pharmacological inhibitors to treat fibrosis 3667 50507 331 114548 4335 10628 2475 3603 948 7099 10333 PMC7774091__F8 Proposed apoptotic pathway for the anticancer compound, SYA013 596 4170 581 54623 PMC7775721__F2 Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease 2720 427 3073 2581 6609 3074 2629 410 54209 PMC7779353__F10 Diagram of a signaling regulatory network that determines the AEC II differentiation phenotype 1499 1636 59272 PMC7780025__F1 Mammalian Hippo‐YAP signaling network 6714 4771 10413 4485 154796 60485 9113 26524 5784 23513 7003 8463 7004 7005 PMC7780675__F8 Schematic illustrating the role of MGMT in HR signaling in NPC cells 4255 5888 672 675 PMC7782843__F1 Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies 6714 7186 6464 2885 5879 2645 998 3845 3265 5894 369 673 572 3297 596 4609 3725 351 PMC7783665__F1 Calcineurin-NFAT pathway for expression of cytokines and cell membrane proteins 958 5336 3558 PMC7783757__F7 Interrelation between 4 target metabolites and 4 concurrently mutated genes 8289 57492 613 8241 64600 10555 1606 1607 8399 5594 8526 8525 10400 8527 1119 5338 3931 23659 2820 6462 1103 57678 60 5764 4175 5335 2 10456 1104 1114 5925 10672 6256 43 11021 5336 4802 1053 1634 11343 10664 80152 6945 10989 2017 226 387 10425 6934 4899 1025 1478 999 55750 2033 4093 3055 1387 3717 1739 5546 55304 165679 3594 9517 1956 4800 473 19 7325 9774 2624 10523 9846 3725 9612 10179 6604 93663 8453 10127 998 7536 10459 PMC7786163__F2 Links among COVID-19, cytokine storms, and HF 6773 6772 6348 6347 3553 PMC7789003__F1 Synthetic view of key functional losses (−) and gains (+) during the evolution of Myzozoa 2242 4514 4512 PMC7789501__F2 Protein–protein interactions for the differentially expressed proteins in ApoE−/−/LDLR−/− mice (vs 5627 847 1636 2155 1509 7412 9370 633 4060 26998 2934 2202 338 5858 7060 345 6291 1431 6288 PMC7791871__F7 YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas 4485 60485 9113 26524 2475 5728 PMC7792208__F1 Multistep model of the evolution of classic ILC and its morphological variants 999 207 5290 5728 2064 7157 2065 8289 8660 PMC7793984__F1 LMP agents and biological factors that induce lysosomal rupture and cell death 5091 4864 3920 3916 PMC7796017__F2 PI3K/AKT/mTOR signaling pathway and breast cancer 1956 3480 2260 6009 PMC7796621__F7 Schematic model of the anti-inflammatory effects of hMuSCs on DSS-induced IBD 196 7124 100187761 PMC7797090__F5 Metabolic pathway of glycerol and glucose bioconversion to butanol in Clostridium sp 2597 3045 100187828 PMC7797171__F5 Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells 3717 6714 891 6667 PMC7801189__F2 Mechanism of cytokine storm caused by SARS-CoV-2 59272 3553 90865 PMC7801250__F3 Synopsis of lysine monomethylation events involved in photosynthesis and carbon metabolism in SynechocystisA 4519 1356 2242 6390 PMC7801429__F2 An ER signaling pathway network identified by IMPALA using Loi breast cancer gene expression data 3643 203068 2064 5580 3691 6714 1956 8660 2885 10174 5335 5159 5788 8651 1759 7454 3667 5791 7534 1398 3932 7249 5578 5584 3303 5747 10971 4067 7529 60 1457 4000 10657 3066 2764 5594 7153 3925 5781 613 1147 3320 1387 3725 3716 6464 1432 836 6774 2353 2002 2113 1385 PMC7801696__F6 LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma 1956 29931 10111 84126 472 PMC7803547__F2 CD8+ T-cell metabolism in COVID-19 324 941 940 9817 2475 3553 PMC7805242__F5 MiTF in osteoclast differentiation 4772 126014 4286 81501 10457 100187907 1513 1186 28962 PMC7812258__F2 Mechanisms through which TLRs orchestrate pro‐tumour responses 8205 338376 596 PMC7813757__F1 Mechanism underlying the role of TLRs in tumor immunity 51284 7096 7099 54106 920 7100 PMC7813845__F2 Role BRD4 in regulating the NFKB pathway in inflammation and immunity 7096 10333 7097 7099 7098 8517 3551 1147 51284 54106 4792 4790 5970 23476 PMC7814595__F2 Functions of T cell subsets in the acute and chronic phases after ischaemic stroke 196 374 3586 PMC7815874__F1 Increasing glycolysis by deletions of kcs1 and arg82 improved SAM production in Saccharomyces cerevisiae 9365 5230 2597 PMC7819868__F1 REG4 signaling pathway 7039 6868 83998 1956 2861 2932 1499 1045 6667 1021 1019 PMC7821223__F5 Transcription-related gene network 2119 2934 6722 10919 8061 6591 84662 6850 PMC7823159__F7 Drosophila Activin signaling promotes muscle growth through InR/TORC1-dependent and -independent processes 4087 253260 6009 5163 7248 7249 207 PMC7823450__F1 Metabolic pathway of oxysterol sulfates 9023 1593 10858 PMC7823498__F1 Biological regulatory network (BRN) of IP3R with tumor suppressor and onco-proteins 5371 5728 2475 572 581 PMC7824874__F2 Key contributions of the UPS to the regulation of the NFKB signaling pathway in response to LPS 7099 7189 4615 90268 7124 PMC7826004__F3 Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms 59272 1636 7939 6476 7113 367 PMC7827067__F2 Pathway map of PIK3CA/AKT 7411 126669 3265 2885 1378 847 5970 4792 5170 5728 2932 619501 5328 572 1017 7448 2064 1080 5598 5782 50488 983 53904 5218 1018 140469 PMC7827308__F8 Simplified representation of intracellular pathways activated upon TLR activation and working mechanism of B18R 7098 51284 51311 4615 3661 3665 103 PMC7828553__F2 FGFR signaling pathway 10818 2549 2885 PMC7829888__F4 Alternative growth factor driven signaling pathways after androgen blockade 1950 3569 6714 3716 367 6774 5728 PMC7830093__F1 Comparative view of wild-type p53 function in ESC maintenance, differentiation, and somatic-cell reprogramming of human and mouse: ESC maintenance: p53 is maintained in an inactive state in both human and mouse ESCs 4193 8805 100187761 79923 23411 6790 79727 6657 4194 9314 PMC7830227__F1 Hippo signaling pathway in mammalian cells 4485 84962 9113 PMC7830279__F1 DSB end resection and repair pathway 9156 5888 5893 PMC7830477__F7 Proposed mechanisms of the antioxidative actions of Pistacia lentiscus var 847 6647 2936 2876 2950 3162 PMC7834957__F11 lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast-like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR-152-3p 324 6424 1499 595 PMC7835514__F1 Mouse lung development and early pseudoglandular branching morphogenesis 7080 2255 64399 2119 2118 6469 1499 6657 6662 3398 7356 PMC7835526__F3 Interplay of IGF-1R-related signaling and niche microenvironment in stemness expressions of different cell types 3481 3479 3480 7852 2475 2064 9242 6657 3273 79923 145258 3570 6352 471 PMC7837592__F3 Understanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets 6714 1956 100187761 920 3939 PMC7838032__F3 The cyclin D–CDK4/6 complex 545 472 2932 1021 1019 1017 PMC7838037__F4 MAPK mediated signaling pathway induced by interleukins leading to mucus hypersecretion 3603 2885 4615 4586 4582 4585 4583 727897 4082 100170220 PMC7840025__F1 Association of a novel endometrial cancer biomarker panel with prognostic risk, platinum insensitivity, and targetable therapeutic options 5295 5290 898 113791 1869 890 5728 2146 84930 22974 6790 9700 57650 5347 2932 2305 675 6502 83990 9156 5888 672 7157 4361 10111 PMC7843730__F2 Mechanistic dissection of diabetic retinopathy using the protein-metabolite interactome 219293 80757 100129669 126123 817 9495 928 818 113177 83639 147719 137797 10369 2893 2892 4646 2036 374 58530 815 7337 8000 7039 81833 57622 4062 2890 8749 80740 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Study Chemosensory Pathway Signaling 387569 2155 2278 PMC7849354__F3 Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling 3042 2155 387569 PMC7850581__F1 Interferon-stimulated GTPases in autoimmune and inflammatory diseases: promising role for the guanylate-binding protein (GBP) family 10379 3716 6773 6772 7297 115362 3717 2633 2634 5970 1499 4040 4041 324 PMC7851696__F1 Critical Role of MetR/MetB/MetC/MetX in Cysteine and Methionine Metabolism, Fungal Development, and Virulence of Alternaria alternata 875 4397 867 23743 2878 PMC7854028__F1 miRNAs participate in the regulation of key genes related to cellular response to IR 1956 407029 472 545 5728 993 406990 2475 581 5591 PMC7854028__F3 IR-induced modulation of miRNAs initials carcinogenesis 5728 581 25 613 PMC7854640__F7 Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution 4853 182 1956 6376 10563 27074 920 1524 1233 643 PMC7854758__F11 On the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model 7959 1380 5741 PMC7854845__F2 UPF1 Activation in the Two Major NMD Branches 23049 9704 56006 55181 5976 26019 65109 PMC7854849__F1 Model indicating roles for MLH proteins in meiotic recombination 80010 80198 6495 51804 5888 11144 4439 4438 9156 PMC7855207__F1 Expanding the Clinical and Metabolic Phenotype of DPM2 deficient Congenital Disorders of Glycosylation 8813 8818 54344 PMC7855837__F1 Elesclomol: a bis(thiohydrazide) amide compound that binds copper in a 1:1 ratio 2230 6647 4015 1621 5066 PMC7858073__F5 Signaling and molecular network mapping of genes differentially expressed in the ileal transcriptome of NCFM-colonized versus germfree mice (24 genes) using the Ingenuity Pathway Analysis software 6368 122042 6036 6355 3640 56169 3587 3265 116071 9966 255061 1628 81858 719 8863 92291 643853 5030 3954 50506 405753 80142 7173 80777 4609 10385 132001 7124 3458 140823 PMC7858668__F1 Complement in diabetic kidney disease 718 1431 966 PMC7858668__F2 Complement cascade and complement targeting therapies 1803 5648 717 720 721 4179 727 729 966 PMC7859793__F5 Protein-protein interaction (PPI) analysis of differentially expressed alternative splicing (DEAS) events 55367 367 7871 10231 6840 8650 4046 50649 9826 2934 58504 84986 3671 2246 5333 8301 2157 2778 81493 1462 5598 1500 10645 176 3643 3953 84987 4638 860 10062 65062 6711 9612 55763 4751 2491 64105 10010 6601 9524 5914 10024 24137 50863 100187761 23648 8496 7549 63967 5802 6144 6122 960 2146 1111 9493 351 5295 PMC7860207__F2 Significantly enriched Cell Cycle pathway from genes with high DE prior probabilities 7040 9126 8243 10274 1029 5933 1874 7027 4087 4089 2932 472 4193 7272 6500 6502 4609 7709 5925 7157 9184 996 991 1111 1026 1647 2810 699 7529 5111 9134 595 902 890 1017 983 891 1019 1022 5347 25 990 8318 3065 4998 4171 1869 8317 10926 4999 23595 5000 23594 5001 PMC7861947__F6 Probable mechanisms of apigenin against liver fibrosis 7039 4313 4088 PMC7862665__F2 E3 ubiquitin ligases in the development and progression of glioblastoma 1956 2885 867 1499 5728 81559 5214 6737 4763 2534 5163 84078 7189 2932 8805 23152 6774 23239 2115 114088 PMC7865460__F3 General metabolic effects of MM-associated oncogenes 894 4094 2932 1021 1019 595 2261 4609 PMC7865811__F3 NFKB pathway by NLRX1 4615 57506 7189 79671 PMC7866155__F1 Targeted Neoadjuvant Therapies in HR+/HER2−Breast Cancers: Challenges for Improving pCR 4838 596 5728 4193 1019 1021 PMC7866785__F7 Regulation pathway of CASC19 in the radioresistance of NPC 103021165 142 2475 PMC7866901__F1 Expression characteristics and prognostic roles of autophagy-related genes in gastric cancer 54986 60673 23130 55102 9706 9821 25989 55062 26100 8408 9776 81671 79065 285973 55626 22863 8678 29982 30849 5289 53349 9474 55054 9140 89849 10533 83734 64422 11337 84557 23710 81631 11345 643246 23766 440738 115201 23192 84938 84971 PMC7867063__F2 Roles of NRF2 in cancer metabolism 5226 2539 5471 6888 7086 10797 4199 2730 2729 PMC7868022__F2 EBV-induced oncogenesis through the PI3K/AKT signaling pathway 2475 2932 6352 1499 PMC7868022__F4 EBV-induced oncogenesis through the MAPK signaling pathway 10152 1848 1850 PMC7868342__F11 Signaling pathways involved in rhFGF20-mediated protection against BBB disruption both in vivo in TBI mice and an in vitro in a TNF-Alpha-induced HBMEC model 2932 1003 3553 PMC7869020__F1 Purine salvage and de novo purine biosynthesis (DNPB) 10606 7808 158 8833 5198 5471 353 PMC7870789__F1 Tumorigenic mechanisms in somatotroph cells 83550 2692 2696 9049 PMC7870803__F10 Diagram depicting the molecular regulation mechanism of the NEAT1/miR-129-5p/PEG3 axis in liver fibrosis of mice with NASH through the NFKB signaling pathway 27161 5178 283131 PMC7870996__F1 Dual regulatory effects of TRAP1 on the mitochondrial apoptotic pathway 7124 10131 1362 83939 468 PMC7873355__F3 Interaction network showing the mutual involvement of DEPs from SACS KO model and ARSACS patients in Engulfment of Cells (A) and Synaptogenesis Signaling Pathway (B) 348 4151 7087 2048 1356 6622 2042 5187 1948 PMC7874400__F7 Critical role of miR-574-5p in ARDS pathogenesis 3553 3146 114548 7099 PMC7875896__F8 Protective mechanism of levo‐tetrahydropalmatine against liver fibrosis 4087 4088 7076 4313 PMC7880430__F2 Finding branched pathways in metabolic network via atom group tracking 1810 1378 1380 65057 5066 PMC7881328__F2 Anti–Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients 3458 1050 5371 6351 4790 6364 1326 3569 1906 5025 3137 8767 6368 64386 6347 4082 7124 3091 57817 941 2015 10010 100187761 3309 196 7187 29923 81502 1431 2885 5595 200734 596 7428 3627 4792 7185 960 978 2920 6648 PMC7884039__F12 Molecular mechanism of p75NTR in regulating age‐associated changes in the homeostatic of synaptic plasticity 627 387 9475 3984 23237 PMC7884467__F1 NLRP3 inflammasome pathway 114548 9365 834 5763 8772 79792 PMC7885408__F9 Role of SIK1 in the transition of acute kidney injury into chronic kidney disease 2932 324 1499 150094 4040 4041 PMC7886702__F5 Molecular and functional profiling of apical versus basolateral small extracellular vesicles derived from primary human proximal tubular epithelial cells under inflammatory conditions 9294 3987 5339 27202 23098 10475 51191 2147 7124 6713 684 629 9244 23547 6772 145864 754 3383 6352 952 718 9447 3458 64806 55065 9618 PMC7887651__F4 Immunometabolic interplay in obesity 847 3661 6774 3667 PMC7889583__F3 Resistance mechanisms to MDSC immunosuppression 7099 4615 6774 10682 406947 PMC7891678__F1 TGFB as a gatekeeper of BMP action in the developing growth plate 7046 4087 4089 4091 4092 94 4090 4086 PMC7892446__F2 Mechanisms by which SARS-CoV-2 promotes muscle wasting and sarcopenia 59272 3480 4088 4087 9021 2475 PMC7893589__F3 Effects of miR-320 on glucose and lipid metabolism in cardiomyocytes 948 3479 27161 PMC7894404__F1 Model‐Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes 54600 1576 7364 PMC7895515__F1 TGFB signaling pathway 7046 7048 387 4089 4087 4088 PMC7896869__F7 Involvement of SAB in enhancing proliferation and attenuating oxidative stress and apoptosis through activation of the JAK2/STAT3 signaling pathway 3717 6774 581 PMC7897195__F4 SFRP2 overexpression in tumor endothelium leads to enhanced tumor angiogenesis via the Wnt/Ca2+signaling pathway 6423 7855 4775 7006 100124696 PMC7897698__F2 Regulatory cascade of MIR211 involving the BRAF/ERK5/DUSP and PDK4 329 406993 5166 PMC7898723__F3 Whole‐exome sequencing of non‐BRCA1/BRCA2 mutation carrier cases at high‐risk for hereditary breast/ovarian cancer 157570 6996 79661 4595 7374 5981 2956 9156 2237 1161 4436 10111 10721 4292 472 2178 11200 2074 22909 2175 8438 PMC7901659__F1 Prostaglandin-Endoperoxide Synthase 2 (PTGS2) in the Oviduct: Roles in Fertilization and Early Embryo Development 27306 4512 4513 5228 PMC7901767__F1 Evidence that a naturally occurring single nucleotide polymorphism in the RagC gene of Leishmania donovani contributes to reduced virulence 23677 201163 64798 PMC7903498__F1 Effect of Melatonin Modulation of Non-coding RNAs on Central Nervous System Disorders: An Updated Review 5728 23411 100033819 283120 PMC7904692__F1 Antiviral pathways in silkworm 27161 5728 1956 PMC7905081__F1 Core components of the Hippo signaling pathway and their regulation in the GV and MI-stage oocyte 154796 4771 4485 60485 9113 26524 PMC7905169__F4 The regulation of TGFB pathway by ubiquitin ligases and DUBs 57154 64750 11059 4088 4087 4089 4092 8237 9958 PMC7909315__F4 F-actin correlation pathway diagram 999 5879 6010 55466 6093 PMC7911116__F1 Activated and deactivated WNT pathway 4040 4041 2932 324 1499 PMC7912342__F5 NLRP3 Inflammasomes signaling pathway 5027 114548 115004 140609 3553 PMC7913053__F1 Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis 50507 7012 25913 1736 7015 1200 PMC7913072__F4 Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases 7040 4087 4088 4089 1499 6722 7939 7124 8772 572 637 581 PMC7914548__F2 Host mucosal responses to C 3603 6364 6279 PMC7914659__F1 Three major sources of H2S: enzymatic pathway, nonenzymatic pathway, and bacterial origins 875 1610 847 PMC7916890__F3 Crosstalk between mTOR signaling and PI3K/Akt pathway 5728 5163 3667 2887 6009 PMC7916982__F9 Iso-Alpha-acids can exert anti-inflammatory activity by inhibiting the NF-kB pathway by acting on several kinases involved upstream and downstream of the signal transduction 3553 7124 660 4615 695 6850 4118 5163 PMC7918750__F4 Human cytomegalovirus (HCMV) microRNA- (miRNA)-mediated reactivation from latency 1956 2549 1958 PMC7920504__F4 Candidate genes for osimertinib resistance presented within cancer-related signal pathway 1950 7039 367 1398 685 3725 1839 4609 126669 3084 2885 79890 9542 2475 572 10718 145957 PMC7921671__F3 Cysteine metabolic circuitries: druggable targets in cancer 875 1431 847 29984 140805 PMC7921671__F5 Cysteine metabolic circuitries: druggable targets in cancer 23152 875 1491 2937 PMC7922079__F4 Targeting EPC expansion as a novel therapeutic strategy 2623 3717 2475 3418 7166 PMC7922220__F2 GnRH-II signaling in ovarian cancer cells assuming that a truncated GnRH-II receptor (A) or no GnRH-II receptor (B) exists 1950 1956 581 3727 PMC7923182__F11 Scheme of reactions proposed for Rho pathway modelling 81029 23002 387 PMC7924042__F7 Catalpol on AMPK pathway in alleviating DN 834 79792 114548 PMC7924360__F1 Modification of PtdIns Mediated by PI3K, PTEN, SHIP, INPP4 and the PI3K signaling pathway in cancer: The phosphorylated state of inositol lipids inserted in the cell membrane is controlled by inositol kinase and phosphatase enzymes 5266 5728 5163 PMC7925333__F3 Major intestinal host defense pathways identified in C. elegans 11016 3091 7494 7942 2309 22809 PMC7926238__EV5 Models for disassembly of the metazoan replisome. The figure summarises data from this manuscript together with previous studies with early embryos of Caenorhabditis elegans and extracts of Xenopus laevis eggs 122769 8453 4172 4174 4173 4175 4171 8318 7353 10293 8481 PMC7927668__F5 KEGG mTOR signaling pathway map comparing +AMR/+DSA and +DSA vs 54468 220441 4342 7054 5728 PMC7930050__F7 GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia 2735 1021 1019 PMC7933006__F2 Reduced Tdo2 expression leads to reduced Trp flux through the kynurenine pathway (KP) 8140 23428 1644 8942 11185 7166 6999 23475 PMC7933966__F6 Schematic underlying mediation mechanism of CRKL on glucose metabolism in hepatocarcinoma 5163 2932 1399 PMC7934064__F2 Mechanisms involved in DDR and checkpoint immunotherapies 6352 545 115004 472 1111 142 PMC7934645__F1 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases 4150 6667 2295 4086 652 9839 6935 5728 283120 PMC7940683__F2 Siglec-G in various immune cells 613 100133941 7099 4067 4772 3146 946 941 23586 867 57506 6774 3661 PMC7943879__F6 Forsythoside A (FTA) attenuates lipopolysaccharide (LPS)-induced endometritis by causing significant changes in the number of miRNAs in bESCs to regulate the target genes involved in different pathway 7099 79132 7097 59067 3569 3559 6374 7189 3572 246778 4283 3576 442896 PMC7945361__F6 Proposed relationships of amphotericin biosynthesis with relevant metabolic pathways in S 11113 1611 4118 PMC7945682__F2 Summary of targets to generate Super-Treg 50943 3133 961 23326 3091 9734 79885 10013 10875 1719 28755 567 4261 3560 3559 3458 2475 861 355 987 65980 196 PMC7946919__F8 Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas 2263 10818 2885 PMC7947301__F1 Regulatory activities of nuclear receptors on the NLRP3 inflammasome priming and activation steps 3552 948 24145 7097 338340 10628 79792 7421 140609 79184 114548 3606 3553 PMC7947610__F5 Abnormal T cell Activation in GCA 942 940 25801 PMC7950759__F3 Smurf ubiquitin ligase activity and protein levels in cancers 10401 9618 3276 3932 207 208 PMC7956553__F1 Cartoon of major proteins in the mechanistic target of rapamycin (mTOR) growth pathway 7249 7248 6009 1977 PMC7956553__F4 Cartoon of mTORC1, Wnt/Beta-catenin, and estrogen receptor A (ERA) molecular pathway interplay in the female-specific, Tsc2-null, rare lung disease lymphangioleiomyomatosis (LAM) 89780 4040 4041 2932 1499 7474 894 PMC7956578__F2 Impact of hypoxia pathway proteins on immune cells and cancer stem cells, and their impact on the development of the tumor 1950 3082 7124 PMC7957536__F1 Leptin signalling 3717 3667 2885 2475 6774 PMC7959192__F9 Simplified pathway for NAD metabolism 10135 93100 23098 PMC7961376__F1 Molecular pathways of novel emerging targets in NSCLC and agents in clinical development 2668 4902 9048 5623 4803 3082 999 4914 4915 4916 5979 3845 2475 6010 5728 1021 1019 PMC7961479__F1 Predominant signaling pathways contributing to melanomagenesis and progression 7249 6009 2475 PMC7962658__F6 Effects of Cryptotanshinone (Cts) on the Akt-GSK-3Beta-mPTP signaling pathway 2932 836 840 PMC7963413__F2 Cascade of events triggered by the overexpression of RB1CC1 in SCZ pathogenesis 7248 7249 9821 PMC7967197__F1 CyclinD/CDK4/6 involvement in overpassing resistance to aromatase inhibitors 1956 1019 2475 PMC7967207__F1 Tannic acid (TA) acts as a repressor for multiple proteins essential in several oncological signaling pathways 3976 3977 1950 1956 7046 6774 4087 4088 4089 6657 PMC7968318__F4 VIRMA and circ_KIAA1429 involved in human cancer progression 4609 101805488 3398 2625 25962 983 7124 253943 6935 PMC7970221__F1 Bioactive nanotherapeutic trends to combat triple negative breast cancer 367 1019 1021 PMC7970325__F10 Reconstructed differential DNA repair molecular network for the comparison of Papillary cancer (PC) vs Follicular adenoma (FA) 79728 2178 2175 2187 55120 2177 1385 10488 468 7529 83990 4292 5888 7533 4661 59348 2874 7014 2033 1387 571 29102 5884 995 3725 64393 5555 672 27244 6477 10521 1956 8445 7186 9656 4683 10111 472 7156 641 1655 545 5883 2232 2810 841 993 374 10379 28996 5728 5591 6667 4609 637 8493 1032 4193 64065 55367 56475 4436 55240 10524 10498 55247 252969 1029 5268 2956 3065 6996 10564 8930 3732 114769 4595 4350 5430 7374 23583 5423 5892 5111 1643 7516 5889 79661 80198 3146 25788 8438 998 7517 7508 2237 7515 5893 5426 3978 27343 1642 3980 2068 2074 56949 5982 9318 9156 4437 PMC7970325__F8 Reconstructed differential DNA repair molecular network for the comparison of Papillary cancer (PC) vs Follicular cancer (FC) 1017 80010 9894 3014 641 4683 29089 7156 8940 64065 1385 1386 468 10488 4361 10111 57697 116028 5883 2189 637 2178 9874 55215 3280 9656 472 2177 57599 55120 8445 2175 7157 4193 55367 7398 28996 1032 11200 2187 79728 6477 2232 545 83990 8626 5395 7533 675 5923 6667 7186 10564 114769 4292 22909 581 5888 5268 85451 5555 23411 64393 27244 10498 998 10379 51512 10524 7465 1026 3732 8493 2033 1387 2810 56475 55247 374 23583 55240 5728 2874 10521 252969 4595 29102 3978 5111 4350 1956 1655 7515 2237 5426 3146 5423 27343 79661 1019 1021 7374 6996 3980 8930 PMC7972846__F7 Effect of ECT on MAPK, AhR, and NFKB signaling pathways in CS-induced lung injury in mice 100379198 196 3603 1431 PMC7974027__F7 Schematic depicting possiblem echanisms governing the pro-tumorigenesis effect of NET and miR181a targets in the PGRMC1/EGFR–PI3K/Akt/mTOR signaling pathway in breastepithelialMCF10Acells 1956 10857 5728 2475 5111 595 596 842 PMC7976506__AF1 Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease 847 637 11113 PMC7976506__F5 Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease 2358 847 11113 637 PMC7976587__F3 Possible feedback loop between PTX3 and TNFA via NFKB signaling pathway in inflammation 5806 3553 2919 PMC7977448__F2 Inflammasome activation 6010 114548 22861 4671 9447 58484 3553 PMC7982061__F2 Notch1 signaling pathway and Notch1 inhibitors 3714 182 54567 28514 10683 102 5045 4609 896 PMC7982428__F1 Hedgehog (HH) signaling pathway and its related regulators, target genes and current therapeutic landscape 2719 91653 11197 2262 2619 156 6608 83737 8452 51715 51684 2735 2737 2736 374654 1950 3845 673 1499 51176 9429 3092 596 648 595 2305 960 PMC7982543__F3 Pathological pathway of “Lipid-toxicity Inflammation” or “Dampness-heat Syndrome”—Insulin Resistance-Metabolic disease 7097 7099 85451 3553 PMC7982600__F1 Known signaling pathways involved in FGF21 expression from skeletal muscle 7249 83939 4654 26291 PMC7985550__F1 PI3K signaling pathway and related target drugs in endothelial cells 2492 2475 3383 PMC7986493__F10 Glycine, serine, and threonine metabolism pathways of L 189 26227 5723 29968 875 PMC7986854__F7 MHC I antigen presentation pathway is down-regulated by multiple mechanisms in cancers 3717 6773 5771 5979 238 121665 51320 27044 PMC7987459__F2 Molecular pathways affected by Mn porphyrins in normal and cancer cell 9817 847 57716 2950 7352 2730 1432 9446 8678 2885 9474 9669 8837 1520 4087 50507 4089 4088 331 PMC7987655__F1 Tourette Syndrome Risk Genes Regulate Mitochondrial Dynamics, Structure, and Function 147381 100190785 85358 PMC7987878__F1 NRs promote tolerance increasing recognition and degradation of apoptotic cells 9474 10533 8678 2621 10461 948 3916 PMC7989008__F5 Re-analysis of 29 selected genes by KEGG pathway enrichment 1021 914 472 545 2242 637 842 836 10572 94005 64065 3486 5728 5555 64326 351 PMC7990077__F5 Proposed mechanistic diagram of the multi-faceted, anti-neoplastic effects of GSE against lung cancer 3481 5740 5728 3482 407975 PMC7990372__F2 Illustration of the processes of iron uptake, storage, and efflux in the retinal pigment epithelium (RPE) cells 148738 55240 94033 7018 7036 3077 PMC7991106__F1 Process of glycometabolism in ECs 2308 3099 5315 5209 2147 2539 PMC7993611__F1 Hypopigmented burn hypertrophic scar contains melanocytes that can be signaled to re-pigment by synthetic alpha-melanocyte stimulating hormone in vitro 5091 4157 4286 7306 1638 PMC7993742__F3 Protein-protein interaction (PPI) of differentially expressed aging-related genes 6633 9277 3656 2192 6185 197257 6194 6141 4637 2091 4869 200916 4605 7168 4638 6223 2199 11224 3945 9212 1062 23223 6136 1636 4173 1164 2934 6357 2920 5028 5347 10576 183 1265 25797 991 8231 1869 6352 58191 7277 56477 150 3934 1520 894 994 8836 1116 11335 9588 567 4609 2938 1030 7422 5270 7037 9510 730 2264 813 2114 7058 1191 338 2263 5054 1805 3655 4314 8985 1634 6696 948 2 3486 652 4316 3673 29984 655 871 4321 4488 3001 10631 9073 4320 1281 1063 11004 5111 3576 11065 890 PMC7995212__F2 ACE2 in the second act of COVID‐19 syndrome: Peptide dysregulation and possible correction with oestrogen 59272 1636 3550 PMC7996097__F8 Mechanism of how taurine relieves S 3569 7099 7097 5163 5728 2475 8408 PMC7998005__F8 miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease 118 9475 27022 PMC7999520__F8 The signaling pathway by which the neogenin ligand RGMc enhances follicular development 5021 6915 4513 4512 27306 79923 1907 146 PMC8000263__F1 Ferroptosis signaling pathway 100 2182 5447 10162 5037 2879 PMC8002431__F4 Gene networks regulating flowering time showing differentially expressed genes in cid3cid4 80742 878 55615 80758 574414 1999 2000 79631 PMC8002730__F3 Core signaling pathways of triple negative breast cancer (TNBC) 29126 56477 387597 2064 998 2033 11320 3417 367 406952 6774 4313 596 58476 8678 940 2736 3091 92140 6935 7852 PMC8002730__F5 Common and distinctive core signaling pathways between triple negative breast cancer (TNBC) and non-triple negative breast cancer (non-TNBC) 6275 29126 56477 5241 387597 2064 11345 998 131566 57561 2033 5601 4609 367 4313 58476 7852 57826 92140 596 8678 940 6935 2736 PMC8002742__F1 The activation of the Toll-like receptor signaling pathway 7096 7097 10333 7099 7100 4615 114609 51311 51284 54106 7098 3661 3665 PMC8003896__F3 Hcy metabolic pathways 4397 4524 875 PMC8005589__F1 Rationale to target mechanistic target of rapamycin (mTOR) in renal cell carcinoma (RCC) 5728 5163 7428 7249 7248 6009 PMC8006920__F4 Pathway enrichment of hubs: The common pathway (red rhombus) shared by three protein hubs (yellow rectangle) extracted from the metalloprotein network 2475 8178 3326 PMC8007363__F7 Smad3-NOX4-derived ROS-mediated p38MAPK/Akt signaling in TGFB1-induced ECM production of HBSMCs 1431 4088 50507 260431 PMC8008218__F6 Study findings 999 1000 5817 PMC8015649__F3 Mitochondrial Pyruvate Carriers are Required for Myocardial Stress Adaptation 26227 10724 8473 5091 PMC8016624__F1 MicroRNAs (miRs) that regulate the apoptotic signaling pathways 8772 637 100126333 56616 331 406940 693193 406987 317 PMC8017015__F2 Regulated cell death pathways in doxorubicin-induced cardiotoxicity 7018 2879 3162 11194 PMC8019825__F8 Summary of the pathological alterations of CRS-3 25759 2885 2475 PMC8020202__F2 Roles and mechanisms of CBS/H2S and CSE/H2S system in breast cancer 3630 6774 875 23411 PMC8020338__F3 Ingenuity pathway analysis of the Toll-like receptor (TLR) signaling pathway in the DH82 cell line treated with B 7189 23118 10454 3725 2002 PMC8021480__F1 Schematics of GSC niches and the redox signaling at play 145258 7018 2247 PMC8023395__F2 Towards personalized treatment for early stage HER2-positive breast cancer 6714 5728 2475 PMC8024338__F8 MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis 4782 1869 595 1019 PMC8024584__F8 MAPK-signaling pathway with 5 selected genes (Ssk1, Pbs2, Ste11, Hog1, and Ssk2), known to be associated with response to osmotic stress 2819 341567 6402 867 PMC8025646__F1 Signals and molecules of pathological phagocytosis between microglia and target cell 718 10461 54209 140885 2621 961 4397 PMC8026647__F4 Reconstructing directed transcriptional networks and master regulators in ccRCC 162967 26030 25894 4214 7105 23030 9586 57507 3566 5338 27106 51710 29121 25842 7775 9095 267 9815 5364 3299 6452 127396 57232 5900 164091 4323 2305 79139 10403 8538 1000 6016 4176 55723 1869 3162 22885 2146 54769 558 128239 4174 4582 5129 84109 664 83478 9319 29128 9619 949 284252 2016 8854 PMC8026967__F3 Beyond DNA repair and chromosome instability—Fanconi anaemia as a cellular senescence-associated syndrome 2178 2176 199990 2189 2175 55120 2187 57697 80233 5888 79728 7516 5889 84464 55159 91442 2177 55215 PMC8027476__F6 Schematic diatgram of CAFs induced renal cancer progression 3717 196 6714 9049 6774 PMC8027489__F1 PI3K/Akt/mTOR signaling and its main components 3667 3716 5728 5163 79172 7249 7248 4193 572 1017 PMC8028134__F6 Pathway of flavonoid biosynthesis in the leaves of C 2147 2152 1636 PMC8033034__F2 Relevant events involving IRE1A and PERK proteins at mitochondria–ER contacts (MERCs) 468 9927 2475 PMC8035314__F3 Signaling via the IR and IGF-1R 2885 572 7249 7248 5728 5163 6009 PMC8036376__F1 Metabolic pathway of clopidogrel and its target receptors 1066 1557 1555 1544 1559 5243 PMC8037238__F1 Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAc Cycling 2821 64841 8473 10724 PMC8038076__F8 GR-SC65 suppresses the PM-induced ROS-dependent apoptosis pathway 7186 7189 351 PMC8038986__F1 Contribution of cell death signaling to blood vessel formation 596 581 11035 197259 PMC8039192__F2 Molecular mechanism of the Hippo signaling cascade 60485 4485 9113 26524 PMC8039192__F3 Mechanism of the lncRNA-mediated regulation of Hippo pathway in cancer 60485 4485 9113 26524 154796 652995 122786 101929639 100874185 103695431 399959 2146 PMC8040471__F7 Proposed model of PAK5-AIF signaling pathway in breast cancer proliferation 57144 581 596 PMC8040901__F2 Involvement of the autophagy pathway in the phospholipids of exosomes from LnCap cells (Lipid Pathway Enrichment Analysis, LIPEA) 9776 9140 9474 10533 PMC8040975__F4 TSP1 in adipose metabolism and obesity 948 961 6774 7040 PMC8041604__F4 Mechanisms of PI3K/Akt/mTOR pathway and MAPK pathway, and inhibitors in ovarian cancer clinical development 23440 5728 5900 9610 7074 2475 4193 572 998 5879 27250 PMC8042281__F1 Pre-existing chromatin features and damage-induced histone modifications regulate the DNA repair pathways 84678 22992 6419 9682 2146 55818 4200 10873 4199 3065 7403 23135 6886 23030 55693 5927 3014 8242 387893 51111 84787 PMC8044931__F2 Molecular mechanisms by which estrogens mediate chemoresistance 6741 545 472 1956 672 596 PMC8047301__F3 Leucine sensing signaling pathway upstream of mTORC1 and the potential role of exercise 201163 7249 6009 PMC8048608__F3 UPR pathway highlighting gene‐expression differences between the low‐risk and high‐risk PSC clusters 22937 7186 22926 7494 468 821 811 596 267 6400 10956 7415 10808 83939 7187 PMC8049868__F1 Recognized pathways of androgen biosynthesis in prostate cancer 6770 1583 1586 8644 1646 PMC8050411__F5 Enriched canonical pathways of the DEGs associated with the p53 signalling pathway identified by IPA, showing gene expression and predicted relationships between top regulated 311 nm UVB DEGs at 6 h and 18 h post-irradiation 472 100187907 9924 5111 3240 545 5728 3726 5371 3725 57103 94005 581 PMC8052633__F2 Interplay between autophagy and DDR 472 142 664 8408 596 2475 165918 672 5888 PMC8055404__F3 Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions 999 2475 2146 1499 9261 PMC8055485__F1 Signaling pathways behind the role of CRP in cancer-induced muscle wasting 1401 3479 3480 3667 6774 5970 5966 2309 2475 6194 1977 PMC8056081__F1 Extreme resistance to viruses in potato and soybean hosts 192670 3084 6295 7018 PMC8058227__F2 Ecdysone production and systemic release in response to dietary nutrient availability 4087 7248 7249 PMC8059100__F8 Schematic presentation of possible mechanism of VERU-111 in CxCa 7157 6774 7077 572 7076 1019 983 PMC8061201__F2 Function of LncRNAs in diabetes-related renal inflammation and fibrosis 114548 1499 378938 1958 PMC8061829__F1 Fungal cell wall: An underexploited target for antifungal therapies 2821 759 1255 730 PMC8062261__F12 TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NFKB activation 7189 81858 4615 51135 3654 8161 PMC8063048__F1 Roles that dopamine receptors play in regulating inflammasome formation as well as NFKB pathway 5478 114548 1410 PMC8063466__F4 Quercetin inhibits overactivation of dormant PMFs induced by Cy 2475 6194 268 PMC8064071__F3 Scheme of the central carbon metabolism and carotenogenesis in C 6120 7086 3652 PMC8064164__F1 Role of cannabidiol in Parkinson’s disease by targeting the WNT/Beta-catenin pathway, oxidative stress and inflammation 4040 4041 2932 324 1499 PMC8064803__F2 Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma 114548 7099 4615 716 717 PMC8065041__F10 This study 50943 6774 9332 4843 942 PMC8065059__F4 Metabolic capabilities among distinct lineages within the Brockarchaeota phylum 65057 2512 4524 PMC8065762__F5 Reductive stress in glutaminolysis 3417 2744 3418 PMC8065911__F7 Schematic diagram showing the effects of ABZ on STAT3/5 signaling pathway via modulating SHP-1 expression 6714 3716 3717 6774 595 PMC8069677__F4 Effect and regulation of the NLRP3 inflammasome during fibrosis 3553 7099 7049 4087 4088 114548 50507 4089 PMC8071448__F2 Examples of functions of human disease-related retrocopies 3178 3159 1356 11191 5728 3643 29127 PMC8072385__F2 Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein 5966 3146 9474 100133941 2475 PMC8072393__F2 Autophagic Organelles in DNA Damage Response 7494 22863 7405 83939 468 9140 9474 22926 PMC8072900__F3 Insulin Resistance in MAFLD 7038 5163 3667 8660 PMC8074247__F4 Analysis of LAGEs Family Gene Signature and Prognostic Relevance in Breast Cancer 1232 260431 351 161823 4117 PMC8076952__F8 Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway 54822 5727 6608 2737 2736 2735 581 PMC8079281__F8 TGF-Beta-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity 7409 7410 5879 4088 83478 58504 PMC8079368__F4 Molecular mechanism of lateral bud differentiation of Pinus massoniana based on high-throughput sequencing 5315 51411 7018 PMC8080387__F5 Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63 8626 5728 2932 1499 PMC8080439__F1 Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications 716 721 717 718 727 5648 324 2271 PMC8080689__F1 Autophagy pathway 9776 22863 2475 9140 9474 64422 10533 83734 PMC8080831__F3 Core components of the Hippo-YAP pathway 84962 2195 9113 26524 4771 122786 23286 4485 PMC8081604__F9 Polydatin Attenuates OGD/R-Induced Neuronal Injury and Spinal Cord Ischemia/Reperfusion Injury by Protecting Mitochondrial Function via Nrf2/ARE Signaling Pathway 4094 9817 581 1728 PMC8081964__F3 MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma 182 3955 8650 4851 1499 6608 5925 2735 960 3280 4790 595 3480 2064 1026 142 8837 PMC8082653__F4 N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies 57721 9127 56339 29102 54487 100302142 200734 79576 6659 23035 79830 51441 60674 57659 54915 253943 4824 64077 378938 8661 6477 200933 999 2146 6935 4087 4088 54890 PMC8082854__F2 Metabolic adaptation mechanism of metastatic organotropism 2173 2475 57016 2627 5163 1152 5091 6772 6390 5625 440 2167 7001 7124 PMC8082996__F9 Serum-derived exosomes containing NEAT1 promote the occurrence of rheumatoid arthritis through regulation of miR-144-3p/ROCK2 axis 283131 9475 1499 595 999 PMC8086286__F2 Expression and regulatory roles of lncRNAs in G-CIMP-low vs G-CIMP-high Glioma: an in-silico analysis 7157 101154753 638 55367 819 5820 84793 3201 100506311 6615 4851 648 27113 3198 4609 112597 50652 2146 6688 1847 1326 255082 898 1969 643911 7074 4616 114915 1848 2261 4303 PMC8091792__F1 Pyroptosis: a new paradigm of cell death for fighting against cancer 114548 58484 9447 22861 3606 3586 3553 3146 581 572 3001 3002 3596 PMC8092118__F3 5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent 5045 3091 9794 4851 3516 4853 4854 4855 28514 10683 54567 595 100188776 4318 PMC8093260__F1 An update on the regulatory mechanisms of NLRP3 inflammasome activation 948 7124 4615 7189 2534 7099 8772 23476 3466 9294 8737 3553 114548 7098 11035 197259 846 7226 345 7097 4067 6850 10628 9927 57506 27202 81030 581 PMC8095092__F2 Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: emphasis on ponatinib 613 596 2885 9846 581 572 PMC8096694__F3 MI-induced cardiac-derived EVs potentially regulate myocardial and brain Nrf2 signaling pathways by intra- and inter-organ communication 7124 9817 9870 PMC8097099__F1 SUMOylation Wrestles With the Occurrence and Development of Breast Cancer 6613 6612 7341 10055 5903 PMC8099467__F4 Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis 7428 1407 5187 8864 84699 PMC8099713__F2 Host innate immune sensing pathway targeted by coronavirus 4615 3434 29110 3661 3665 57506 9688 PMC8099721__F1 Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11 693207 79727 619501 3845 54619 222584 5566 7852 9448 123920 23767 51552 4060 PMC8100938__F3 Platelets orchestrate the prothrombotic immune response in venous thrombosis 7450 3606 7097 7018 3146 3579 PMC8101356__F5 Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism 2017 4133 5788 9815 998 7408 79784 7454 5728 391 6418 6010 1232 4118 28964 50618 85464 847 54961 23092 54434 11034 2934 5662 2050 1627 PMC8101356__F6 Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism 11278 6925 8850 248 9039 1380 5970 1107 8650 3687 57506 998 334 920 4049 7462 3479 208 3683 4878 10018 PMC8101358__F1 Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome 26191 51573 63874 6395 2166 55304 10558 9517 8560 130367 81537 PMC8101438__F2 MTOR signaling pathway and its role in metabolic programs and differentiation of T-cell subsets 790 9021 6775 7942 4088 4089 572 1236 355 9655 6778 PMC8102455__F2 Fabry Disease: The Current Treatment Landscape 2720 9331 53947 2717 3073 8706 PMC8103095__F3 miR‐33 regulates hepatic lipoprotein metabolism, fibrosis, and regeneration 338 54677 3032 1374 3156 8660 19 5205 8647 1581 595 1021 6497 PMC8103580__F1 Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy 355 8772 790 2021 331 27429 637 317 596 581 1509 PMC8103724__F1 Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion 2475 64223 8408 9706 9776 22863 64422 10533 9140 8673 9342 55014 PMC8106045__F1 Physiology and pathophysiology of copper transport and metabolism 1356 475 540 PMC8107117__F5 YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance 10413 4485 9113 26524 PMC8107416__F1 DHODH and cancer: promising prospects to be explored 790 7372 4975 1723 PMC8110656__F8 I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway 2670 572 581 2932 PMC8112447__F3 Zebrafish Cancer Predisposition Models 324 4040 4041 2932 1499 2475 5728 7248 7249 6009 PMC8112476__F1 Targeting inflammation in atherosclerosis — from experimental insights to the clinic 6354 114548 3553 7035 PMC8113030__F5 Redox regulation of the insulin signalling pathway 3630 9798 5163 207 208 6446 3479 3481 3667 3480 3488 3484 3485 3489 3486 3487 5728 10000 PMC8116828__F1 Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis 7124 339855 124976 3952 6696 6694 11331 PMC8119379__F2 De-coding genetic risk variants in type 1 diabetes 2524 3627 28 3454 3455 7297 6772 3716 3661 941 867 3606 324 53347 64127 7535 3932 920 1512 5163 10666 961 5350 140885 3558 3002 3458 7098 PMC8120225__F3 MicroRNAs in the osteogenic and chondrogenic differentiation of mesenchymal stem cells and bone pathologies 4092 64750 4087 4088 4089 9759 10454 8195 1749 4090 4086 PMC8123809__F1 Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology 1499 860 652 650 PMC8123861__F1 PGC-1A in the Mitochondrial NAD+ Pool in Metabolic Diseases 130013 64802 349565 23057 952 10135 PMC8124305__F3 S-Nitrosylation in Tumor Microenvironment 7124 6714 6774 355 3552 3458 962 3082 4313 4318 595 PMC8125511__F5 Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production 3455 3716 6772 3454 7297 6773 10379 3661 6890 29110 PMC8126061__SF1 Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells 355 995 983 891 PMC8126571__F1 Bidirectional microglia–neuron interactions in the healthy or stressed brain 627 1435 3146 3553 PMC8127222__F1 Emerging role of the KCTD proteins in cancer 6469 6608 2735 3065 79047 PMC8127406__F7 Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses 2475 26291 8192 9518 27429 400916 7494 51142 PMC8130364__F1 Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy 673 9839 4507 PMC8131840__F2 Complexity of the Tumor Microenvironment and Its Role in Acute Lymphoblastic Leukemia: Implications for Therapies 3718 3716 5163 6772 6774 PMC8131909__F1 Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges 22943 1956 324 1499 695 2475 1021 1019 238 4087 4088 4089 6608 7046 PMC8139422__F7 SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation 59272 5970 6772 629 718 715 716 4179 PMC8139556__F1 PI3K Inhibition in the Treatment of Breast Cancer, Alone or Combined With Immune Checkpoint Inhibitors 5728 8821 5163 2475 PMC8141035__F5 The actions of Pirh2 and KLHDC10 in mammalian RQC 4553 9147 138428 23008 55139 PMC8144465__F4 Cannabidiol Modulates Mitochondrial Redox and Dynamics in MCF7 Cancer Cells: A Study Using Fluorescence Lifetime Imaging Microscopy of NAD(P)H 581 2539 7416 7442 847 PMC8145606__F11 Anti-Tumor Effect and Mechanism of Triterpenoids in Rhus chinensis Mill. on Reversing Effector CD8+ T-cells Dysfunction by Targeting Glycolysis Pathways in Colorectal Cancer 940 324 3458 2475 355 100187761 3939 286205 PMC8145743__F8 CDDO-Me Attenuates Astroglial Autophagy via Nrf2-, ERK1/2-SP1- and Src-CK2-PTEN-PI3K/AKT-Mediated Signaling Pathways in the Hippocampus of Chronic Epilepsy Rats 6667 5728 2932 PMC8146031__F2 Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels 4609 5728 3479 4118 PMC8146031__F8 Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels 545 100133941 100507436 7161 5742 7852 374 3122 PMC8147474__F3 Maintenance of Skeletal Muscle to Counteract Sarcopenia in Patients with Advanced Chronic Kidney Disease and Especially Those Undergoing Hemodialysis 4087 4088 7421 PMC8148124__F3 Calcium and Redox Liaison: A Key Role of Selenoprotein N in Skeletal Muscle 22926 7494 1998 PMC8149954__F1 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization 50507 3661 6778 114548 3553 9535 468 6347 PMC8149954__F3 Ironing Out the Details: How Iron Orchestrates Macrophage Polarization 8651 6778 8841 PMC8151274__F4 MiR-21 in the Cancers of the Digestive System and Its Potential Role as a Diagnostic, Predictive, and Therapeutic Biomarker 387569 836 842 4089 572 324 1630 4437 2956 8066 PMC8151747__F1 Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis 7167 157739 5230 5132 7083 6886 PMC8151747__F2 Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis 7083 6886 5640 PMC8153896__F4 Molecular Dynamics-Based Allosteric Prediction Method to Design Key Residues in Threonine Dehydrogenase for Amino-Acid Production 7067 7068 3712 2689 PMC8160090__F1 JAK-STAT in Early Hematopoiesis and Leukemia 6387 3953 7173 6774 7297 3718 1208 3716 3717 8833 6772 PMC8163534__F8 Pharmacological Mechanisms Underlying the Therapeutic Effects of Danhong Injection on Cerebral Ischemia 6651 5728 4117 PMC8165552__F1 Mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis 4190 2805 2806 4191 7263 23474 717 58472 718 PMC8166058__F5 Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer 6654 200734 161742 4763 PMC8169871__F2 Alterations in brain metabolite concentrations and brain gene expression in AD 1593 9023 51302 10858 10654 2224 39 3157 3156 4598 4597 6713 4047 2222 1581 1576 1583 1718 7108 6309 1717 1595 7454 PMC8171813__F1 Immune cell involvement after cardiac injury 1401 729230 114548 PMC8172013__F1 Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling 6422 1499 324 22943 2932 4041 4040 147111 PMC8172449__F1 NAD metabolome and metabolic pathways 7173 125061 8564 8942 23498 4837 1571 23475 952 23098 64802 10135 2597 203447 55739 128240 PMC8173054__F1 Endocannabinoids and Precision Medicine for Mood Disorders and Suicide 222236 7442 139760 2166 PMC8174116__F5 Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer 57578 3488 2494 58489 8821 29106 29953 84624 117247 5629 285025 135228 51316 3375 3977 27250 1728 57633 195814 26033 10551 259266 27346 6506 6533 400961 10863 5166 55283 84951 10903 57628 10643 8671 1909 4883 6542 23621 55785 2043 94234 169026 5801 5577 9493 129642 8013 10590 2568 4318 9899 1462 4897 8853 4973 54566 219790 3694 388125 113146 7832 79905 4008 54443 5063 8828 2104 27165 3673 1290 51473 3773 160851 164832 130120 1301 283209 79083 55808 11082 1293 33 8796 137872 9068 1281 23768 2115 22943 5314 7058 5099 2157 2706 2167 4323 1303 4148 158326 9833 8754 1277 PMC8178367__F5 Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells 2582 351 666 5447 468 1998 22926 596 7186 581 100506742 PMC8181394__F3 Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy 3949 6713 3156 759 56342 PMC8181544__F2 Is the Endothelium the Missing Link in the Pathophysiology and Treatment of COVID-19 Complications? 59272 718 727 PMC8181875__F2 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer 3845 6774 768 5888 11079 5091 PMC8181875__F3 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer 407009 10628 406992 407027 3205 999 8626 27122 7476 5728 1499 1000 PMC8182936__GA Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway 100187761 114548 3553 PMC8183045__F8 Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis 2695 3652 4221 PMC8185197__F1 Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic Treatment 6194 31 32 4891 7422 8452 3939 2271 PMC8187289__F1 CRISPR-Cas9 delivery 51284 51311 54106 5066 9447 PMC8187902__F2 Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms 902 7465 5728 1022 898 1017 5925 1021 1019 983 324 7422 51343 442917 4193 PMC8187902__F3 Breast Cancer Resistance to Cyclin-Dependent Kinases 4/6 Inhibitors: Intricacy of the Molecular Mechanisms 1021 1019 1956 2064 4094 2475 2099 1017 5542 6667 3169 7031 PMC8192756__F10 Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway 7189 929 4615 PMC8193943__F1 Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy 1024 1025 7189 4087 4089 64750 57154 4091 4092 23327 PMC8194085__F1 Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine 790 7372 978 718 717 1723 PMC8194229__F3 Novel method to identify gene interaction patterns 547 1314 3797 22920 6332 377 8729 23299 113220 6712 1315 286 53407 6708 51164 6955 8775 1638 8774 9371 11127 22796 23095 64689 11316 6293 51200 7110 8674 51560 9632 51542 83871 9919 26984 10342 PMC8196589__F1 Estrogens and Progestogens in Triple Negative Breast Cancer: Do They Harm? 367 1956 6714 PMC8196898__F5 Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer 4513 54567 182 9794 4851 23462 3664 596 4318 246744 1311 PMC8198060__F2 Ubiquitin Proteasome Pathway Transcriptome in Epithelial Ovarian Cancer 2177 55215 672 84464 55120 29089 2176 2175 2187 7398 PMC8198713__F12 Novel Characterization of Constipation Phenotypes in ICR Mice Orally Administrated with Polystyrene Microplastics 4583 360 343 1080 PMC8198784__F3 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis 7412 23152 196 PMC8198784__F5 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis 2859 2475 8205 6774 PMC8198874__F3 Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis 64781 2583 8705 50853 7429 5091 6611 PMC8198882__F1 Inflammasome NLRP3 Potentially Links Obesity-Associated Low-Grade Systemic Inflammation and Insulin Resistance with Alzheimer’s Disease 2475 253260 6009 2308 PMC8199164__F4 Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer 3014 9656 10733 8914 100126333 10111 4361 545 9025 165918 672 8829 5888 406958 406985 51455 PMC8199451__F1 Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What Can Be Learned from Other Coronaviruses 22926 7494 468 83939 PMC8201093__F2 Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric Cancer 1874 29028 1869 1870 1871 10927 PMC8201174__F3 Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGFB and the Ubiquitin-Proteasome Pathway 641 23327 4089 4087 64750 10273 50507 6502 PMC8201988__F5 Integrative Ranking of Enhancer Networks Facilitates the Discovery of Epigenetic Markers in Cancer 3479 1950 1956 1610 5624 4193 1019 581 51426 PMC8203498__F1 Representation of the signaling pathways involved in B-cell clonogenicity induced by clonogenic vp17s 4436 1956 1017 5894 3716 PMC8210554__F3 Circular RNAs as novel potential biomarkers for pancreatic cancer 100126307 100302208 1277 PMC8210559__F5 HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer 6657 79923 2146 23512 8726 3202 999 1000 6935 PMC8211286__F1 Schematic presentation of IL-6/JAK/STAT3 pathway in pancreatic cancer cells and tumor microenvironment 100653366 6774 8205 3845 6935 PMC8211811__F4 DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma 285761 5829 4323 5328 7077 3688 7414 4313 5329 800 27286 7094 87 649 308 29940 115908 55454 3269 83742 9180 4017 858 51375 11010 121457 9902 9260 144165 55342 118429 1001 1508 57120 54947 4478 56937 871 51330 PMC8215710__F1 RIPK1-Associated Inborn Errors of Innate Immunity 7124 8737 8717 7186 23118 257397 8772 114548 PMC8216348__F9 Computational-Based Drug Repurposing Method Targeting SARS-CoV-2 and its Neurological Manifestations Genes and Signaling Pathways 7422 6401 3569 154 5743 1244 2717 PMC8217435__F1 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far 7098 100187907 3661 29110 3665 57506 7297 3454 3455 3716 6773 6772 10379 3434 163702 3459 3460 PMC8219921__F1 Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System 283120 1499 114614 9839 6935 5725 378938 324 285958 6657 84981 347689 595 1956 PMC8220148__F5 Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer 5770 5604 4170 3156 3718 2475 1129 6721 1514 8658 6097 2260 7046 90 7298 5241 1610 7055 80351 5290 993 3791 4318 3577 3359 3815 6714 43 5979 5550 5732 7421 762 5753 4313 766 771 4129 4843 10062 5578 1432 8569 695 135 3579 847 5467 238 3717 590 2100 367 6095 9536 6795 5423 7040 2099 983 1956 2908 23632 3832 25 126669 6790 4282 2322 4322 7376 79068 50507 PMC8220148__F7 Using Network Pharmacology and Molecular Docking to Explore the Mechanism of Shan Ci Gu (Cremastra appendiculata) Against Non-Small Cell Lung Cancer 1565 100187761 581 572 638 3725 2353 1019 6651 2077 PMC8222670__F4 Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition 4513 1950 1499 2932 9839 6935 387 PMC8224563__F1 Autophagy Induction as a Host-Directed Therapeutic Strategy against Mycobacterium tuberculosis Infection 7249 7248 22863 7405 9776 8408 9706 60673 23410 23411 10133 5027 PMC8225153__F3 Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety 4035 3416 351 627 847 7124 43 PMC8225153__F4 Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety 2475 1499 581 891 6774 983 1017 PMC8226042__F1 Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis 59272 7124 3569 3586 PMC8226122__F4 Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies 5340 9015 715 718 727 10747 PMC8228802__F2 ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development 472 672 1386 3014 993 1017 9874 983 581 637 5883 PMC8231806__F6 Dietary Curcumin Alleviated Acute Ileum Damage of Ducks (Anas platyrhynchos) Induced by AFB1 through Regulating Nrf2-ARE and NFKB Signaling Pathways 9817 847 1728 2729 2730 7099 10628 114548 5970 PMC8231835__F1 MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis 1499 6774 1487 7078 5728 116113 8091 6714 6657 857 PMC8232321__F2 BMP Pathway in Blood Vessel and Lymphatic Vessel Biology 7422 4149 23462 55273 182 1948 168667 PMC8232755__F7 DLX Genes: Roles in Development and Cancer 1499 3156 10499 6667 10654 PMC8233004__F5 Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development 3652 4598 4597 PMC8233862__F4 Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis 3479 9242 2475 PMC8234087__F2 ChoK-Full of Potential: Choline Kinase in B Cell and T Cell Malignancies 958 7187 1119 7099 613 4609 10400 5130 5091 4099 79888 2166 144811 8395 113026 PMC8235365__F10 Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction 969 7099 941 PMC8235527__F1 Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System 6009 5728 5163 7249 7248 PMC8238121__F1 PARP Inhibitors in the Ovarian Cancer Microenvironment: Moving Forward From Synthetic Lethality 5888 115004 6352 3627 29110 PMC8241768__F1 Molecular Genetics of Marfan Syndrome 4087 4088 4089 6497 7939 PMC8246597__F11 AMBRA1 regulates cyclin D protein stability and signalling through the RB pathway 9978 8450 1642 55626 1019 1021 6957 PMC8246814__F2 Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation 940 23152 948 PMC8247097__F1 Correction to: Pyroptosis: a new paradigm of cell death for fighting against cancer 114548 58484 9447 22861 3606 3596 3553 3146 581 572 3002 3001 3586 PMC8249129__F8 Therapeutic Targets and Mechanism of Xingpi Jieyu Decoction in Depression: A Network Pharmacology Study 759 6714 596 2932 2475 4609 PMC8249349__F2 Pancreatic cancers rely on autophagy and lysosomal scavenging 8408 2475 9776 60673 22863 23192 10533 64422 9140 9474 55054 55014 PMC8249453__F4 Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer’s disease 4023 91860 4697 4694 4700 55967 4707 4708 4723 4729 4715 7386 516 509 90550 572 54205 842 PMC8250138__F2 Tetraspanins: Novel Molecular Regulators of Gastric Cancer 975 10098 3732 1956 10867 1869 1019 PMC8255023__F4 Aberrantly methylated-differentially genes and pathways among Iranian patients with colorectal cancer 147111 50964 4040 4041 25805 2040 27130 324 387 6500 4088 51701 PMC8256158__F7 Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation 7097 10333 6774 3716 6667 7124 7099 PMC8257046__F8 SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects 387 6093 1856 57619 5879 PMC8257394__F4 Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC 5008 10207 2588 8038 7450 7253 3084 8775 84260 6124 7430 325 1398 7054 5476 54971 100187761 699 5184 84132 PMC8258133__F2 Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells 100302142 9242 63976 10682 PMC8259581__F2 Corrigendum: Signaling Pathways Regulating Thermogenesis 655 4090 4086 80326 4088 4513 PMC8261290__F3 Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti 10577 95 4615 PMC8261291__F1 Targeting Bruton’s Tyrosine Kinase in CLL 613 973 4067 6850 29760 695 5336 930 2475 PMC8262210__F5 Wnt3a/Beta-Catenin/CBP Activation in the Progression of Cervical Intraepithelial Neoplasia 89780 1499 9314 6657 8626 PMC8262334__F2 Gastric Cancer Stem Cells: A Glimpse on Metabolic Reprogramming 57167 3091 2023 5310 PMC8262573__F1 Translational Control is an Emerging Mechanism of Programmed Cell Death Ligand 1 (PD-L1)/Programmed Cell Death Protein 1 (PD-1) Regulation in Cancer 3458 83939 4609 6772 9669 PMC8262770__F1 Metabolic Control of Smoldering Neuroinflammation 64805 338773 3099 2475 3091 PMC8263695__F1 Targeting the eicosanoid pathway in hepatocellular carcinoma 5228 4513 4512 PMC8264452__F1 Use of Biologic Modifiers as a Bridge to Hematopoietic Cell Transplantation in Primary Immune Regulatory Disorders 324 942 987 5163 PMC8264455__F1 Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing 9817 4094 6420 PMC8264592__F2 Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence 581 2475 6714 3383 PMC8265195__F3 Drug-drug-gene Interactions as Mediators of Adverse Drug Reactions to Diclofenac and Statins: A Case Report and Literature Review 95 10864 9356 9376 8714 1244 9429 55867 1559 1558 1557 1576 1562 2938 2950 PMC8265274__F3 F-Actin Dynamics in the Regulation of Endosomal Recycling and Immune Synapse Assembly 324 90410 6845 3383 8675 941 942 403 200894 4118 940 8723 9341 9094 64423 5879 998 8934 11021 79140 PMC8267412__F3 Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer 3845 23550 6382 382 PMC8267830__F1 Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network 5728 7054 2887 64798 7249 5163 2932 PMC8268416__F1 Plant responses to geminivirus infection: guardians of the plant immunity 2009 100187907 2897 9474 10533 7514 PMC8268646__F1 From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment 23765 64806 55540 7186 7189 132014 84818 PMC8268779__F1 Anti-Inflammatory Drugs in Patients with Ischemic Heart Disease 4512 5228 4513 PMC8268872__F1 Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling 3667 2475 2885 PMC8269350__F1 Possible Link between SARS-CoV-2 Infection and Parkinson’s Disease: The Role of Toll-Like Receptor 4 929 7099 4615 7189 PMC8272378__F2 Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis 6138 2731 11019 275 2653 4731 1312 220074 5164 1738 8803 3945 55902 3420 3421 5827 594 1629 4942 1743 4967 3091 10157 PMC8272721__F6 Proposed model of selective anticancer activity of NSLC01 in cancer cells with high NRF2 activation 440 29904 1938 26227 29968 5723 PMC8273913__F3 Integrated Analysis of Microarray and RNA-Seq Data for the Identification of Hub Genes and Networks Involved in the Pancreatic Cancer 1950 3611 6010 998 PMC8273913__F4 Integrated Analysis of Microarray and RNA-Seq Data for the Identification of Hub Genes and Networks Involved in the Pancreatic Cancer 7054 3082 7039 1950 2316 4087 4088 7408 7414 3611 387 998 2475 1611 7422 PMC8274420__F4 Novel Prognostic Biomarkers in Metastatic and Locally Advanced Colorectal Cancer: Micronuclei Frequency and Telomerase Activity in Peripheral Blood Lymphocytes 4087 4088 4092 4089 1950 1956 2475 5728 7015 1499 3091 7012 324 PMC8275894__F1 Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes 5771 3558 3559 26191 50943 326 PMC8276946__F2 Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies 8772 355 1616 581 PMC8277821__F8 Schematic diagram of miR-301a-3p based signalling circuit of trastuzumab resistance in HER2-positive GC 3480 2260 26018 PMC8278519__F2 Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities 3458 3565 3976 4015 PMC8278735__F6 Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NFKB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation 7099 4615 3569 3553 11315 9817 PMC8280127__F8 HOTAIRM1 working mechanism 93663 387 596 100506311 6093 10018 PMC8281607__F2 Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation 84188 55711 8443 255043 10400 PMC8281885__F2 Chemoresistance and Metastasis in Breast Cancer Molecular Mechanisms and Novel Clinical Strategies 2475 3717 6774 1499 4041 4040 4087 4088 4089 51684 6608 2735 2736 60485 4485 26524 9113 PMC8282058__F6 Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer’s Disease: Implications for Treatment 9900 23621 351 3481 3482 PMC8282409__F2 New Insights on the Early Interaction Between Typhoid and Non-typhoid Salmonella Serovars and the Host Cells 2633 4671 7099 114548 58484 81793 PMC8283590__F2 Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update 9112 6714 2920 PMC8283745__F2 Four categories of regulatory mechanisms for nucleic acid-sensing Toll-like receptors 54106 9427 55315 23646 122618 1777 285852 80231 81622 PMC8285596__F8 Virilizing doses of testosterone decrease circulating insulin levels and differentially regulate insulin signaling in liver and adipose tissue of females 208 2308 5468 3643 3667 2099 367 PMC8289367__F3 Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer 5212 54915 7514 PMC8291349__F1 Bile acid and oxysterol synthesis in the liver and other tissues 25801 1581 1582 1593 1576 570 51302 9420 10858 PMC8293156__F2 Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation 4615 4841 717 5163 2932 2534 581 7249 7248 627 842 836 2904 759 273 2043 PMC8294041__F8 Cancer Preventive and Therapeutic Potential of Banana and Its Bioactive Constituents: A Systematic, Comprehensive, and Mechanistic Review 1950 467 2885 1956 1958 4286 581 PMC8296533__F1 Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment 1435 6387 5155 2247 56477 10630 56034 4322 PMC8297384__F1 Regulatory T Cells in Epicutaneous Immunotherapy for Food Allergy 9332 2919 2920 9021 29851 4179 942 941 3902 920 PMC8298384__F9 Anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice 2308 2932 5770 3667 PMC8299052__F1 MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1A/SIRT3 Signaling Pathway 221154 10367 63933 90550 55013 PMC8299052__F4 MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1A/SIRT3 Signaling Pathway 23410 90550 8011 PMC8299113__F1 Gold Nanomaterials and Bone/Cartilage Tissue Engineering: Biomedical Applications and Molecular Mechanisms 860 650 1499 PMC8299191__F6 Map of dimorphic switching-related signaling pathways in Sporothrix schenckii based on its transcriptome 3258 2819 10518 10519 998 10928 PMC8299478__F1 Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients 6916 4512 4048 4015 PMC8301600__F2 Alphaherpesvirus-mediated innate immune evasion 3428 1660 115004 83480 9447 834 3661 29110 7096 7097 4615 3454 PMC8302073__F1 Live Cell Imaging of Nuclear Actin Filaments and Heterochromatic Repair foci in Drosophila and Mouse Cells 79677 23137 472 9156 641 6676 5888 PMC8303588__F2 TGFB Signaling: From Tissue Fibrosis to Tumor Microenvironment 387 2475 2885 PMC8304501__F1 Oncolytic Virus-Induced Autophagy in Glioblastoma 7248 7249 6009 1612 5728 2475 7405 PMC8304542__F2 Anti-VEGF(R) Drug Discovery Legacy: Improving Attrition Rates by Breaking the Vicious Cycle of Angiogenesis in Cancer 7424 2277 7422 7423 5281 PMC8304605__F1 Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease 2932 51684 6608 5727 596 374918 PMC8305593__F1 An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells 7054 596 4193 3932 920 11091 6775 3458 3565 PMC8306148__F1 Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells 55366 2932 324 5163 7249 6863 607 6009 26108 2735 2475 374654 51684 2736 2737 6469 84976 6608 PMC8306223__F2 Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma 7157 4087 4088 302 2354 348 9869 6647 PMC8306455__F2 Evasion of the Host Immune Response by Betaherpesviruses 115004 100187907 29110 3661 PMC8306455__F3 Evasion of the Host Immune Response by Betaherpesviruses 4615 7189 7187 29110 3661 PMC8306561__F2 Autophagy Inhibition in BRAF-Driven Cancers 9776 60673 9474 22863 10533 64422 83734 PMC8306561__F3 Autophagy Inhibition in BRAF-Driven Cancers 6009 7249 8408 673 7942 7030 4193 83939 468 10533 PMC8306625__F3 PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases 114548 57506 55655 10628 8011 PMC8306788__F1 Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review 4485 26524 9113 PMC8307022__F1 Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer 2932 1499 5728 7249 7248 PMC8307280__F2 Harnessing Carcinoma Cell Plasticity Mediated by TGFB Signaling 4089 4087 4088 PMC8314463__F1 Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice 3156 3652 6009 6010 PMC8316339__F5 Apicoplast isoprenoid biosynthesis is critical for P. falciparum survival of febrile temperatures 5878 9230 7939 3652 PMC8316833__F3 SUMO and SUMOylation Pathway at the Forefront of Host Immune Response 3660 3662 3394 85363 3659 3661 3665 5817 23118 6774 9314 6772 3726 PMC8317503__F1 Knockout Gene-Based Evidence for PIWI-Interacting RNA Pathway in Mammals 91646 221400 54514 56165 56154 122402 90853 29947 1788 PMC8318647__F1 Therapeutic mechanism of traditional Chinese medicine monomers on neurological recovery after spinal cord injury 4040 4041 324 1499 6104 607 PMC8318774__F12 Huotan Jiedu Tongluo Decoction Inhibits Balloon-Injury-Induced Carotid Artery Intimal Hyperplasia in the Rat through the PERK-eIF2Alpha-ATF4 Pathway and Autophagy Mediation 468 22926 9140 PMC8318926__F1 Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy 4841 2919 387 PMC8321873__F2 Metabolic Strategies for Inhibiting Cancer Development 2147 5230 5315 9049 47 PMC8323007__F3 MicroRNA-490-3p and −490-5p in carcinogenesis: Separate or the same goal? 55122 6774 7422 4040 4041 10023 2932 80351 1499 4293 100507056 699 1956 60436 7046 4087 4088 4089 6667 5290 7416 7249 7248 2475 387 595 PMC8323226__F5 Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications 941 942 3466 9332 PMC8323701__F1 Dehydroepiandrosterone sulfate as a scavenging antioxidant: the evidence from Caenorhabditis elegans’ nervous system under hypoxia 208 207 5163 847 PMC8324353__F6 Antitumor Effect of Lenvatinib Combined with Alisertib in Hepatocellular Carcinoma by Targeting the DNA Damage Pathway 6741 994 995 545 675 672 993 472 PMC8324723__F1 Forecasting early onset diminished ovarian reserve for young reproductive age women 632 5443 5617 5241 5970 7251 8202 6774 573 10499 10011 183 9332 7341 6908 154 6590 367 PMC8326120__F2 Non-shivering Thermogenesis Signalling Regulation and Potential Therapeutic Applications of Brown Adipose Tissue 2638 7350 7038 PMC8326529__F1 Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis 3725 3553 7157 PMC8327397__F6 Sphingolipid metabolism and the enzymes directly participating in the ceramide synthesis pathway 196 1674 6611 64781 PMC8332860__F7 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells 613 930 5447 5066 6850 5879 5728 2669 51074 7249 6009 572 5934 4170 150365 4602 1975 PMC8332860__F8 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells 83876 7124 3466 7099 3014 8772 7098 2669 8975 5447 5008 847 90865 4015 PMC8341640__F1 Critical Role of PARPs in Regulating Innate Immune Responses 142 10039 10038 6741 115004 3661 29110 PMC8341640__F2 Critical Role of PARPs in Regulating Innate Immune Responses 83666 3661 10000 3665 196 29110 PMC8341640__F3 Critical Role of PARPs in Regulating Innate Immune Responses 64761 142 84875 4615 3146 PMC8342223__F3 Complex role of AIM2 in autoimmune diseases and cancers 9927 9447 3553 2475 50616 PMC8345866__F8 Summary scheme for potential drugs to target the Wnt-AMPK-mTOR pathway during epileptogenesis 26959 6422 2290 7479 1499 5166 2475 64840 PMC8346978__F2 Molecular Pathogenesis of Psoriasis and Biomarkers Reflecting Disease Activity 7124 729230 114548 472 6347 PMC8347567__F10 Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGFB1 Signaling Pathway 4088 3717 6774 PMC8348034__F6 Cigarette Smoke Condensate Exposure Induces Receptor for Advanced Glycation End-Products (RAGE)-Dependent Sterile Inflammation in Amniotic Epithelial Cells 3146 3553 3569 PMC8349889__F7 Gene regulation by EGR1 in ABC DLBCL 3716 1958 4609 6850 695 613 23476 3665 4665 7297 6772 PMC8351602__F1 Intrinsic and extrinsic apoptotic signaling pathways 581 8772 637 PMC8353181__F3 Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver Disease 920 6387 7852 9242 619501 PMC8353874__F1 Triple-negative breast cancer: understanding Wnt signaling in drug resistance 1499 4040 4041 998 2932 324 100187761 23002 387 960 1956 595 PMC8356873__F1 Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma 9817 8452 4094 1728 PMC8357146__F7 Regulatory mechanism of ASPN and DCN: We have proposed a Schematic illustration of the mechanism based on our conclusion 4087 4088 4089 PMC8358930__F1 Biological Significance of YAP/TAZ in Pancreatic Ductal Adenocarcinoma 4485 26524 9113 PMC8365877__F3 Immunological Involvement of MicroRNAs in the Key Events of Systemic Lupus Erythematosus 930 100302142 5728 581 1879 4067 613 4064 958 941 942 PMC8367056__F4 Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy 1499 9113 26524 4485 PMC8369345__F1 Role for Frizzled and Their Post-Translational Modifications in the Mammalian Central Nervous System 4040 6259 324 2932 1499 6010 847 PMC8369417__F3 Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases 7097 10333 7096 7099 4615 7189 5879 4772 3661 PMC8369418__F1 NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo 125061 8564 8942 120103 23498 130013 23475 6581 93100 92014 349565 23530 23057 203447 64802 84561 952 23098 PMC8371405__F2 Long Non-coding RNAs on Bladder Cancer 283120 1789 55000 9839 378938 94234 3845 6935 6624 652995 100124700 PMC8372643__F2 HIF1Alpha-PFKFB3 Pathway in Diabetic Retinopathy 3091 5209 54567 2147 PMC8375436__F7 Key Gene and Functional Pathways Identified in Unexplained Recurrent Spontaneous Abortion Using Targeted RNA Sequencing and Clinical Analysis 920 3595 3586 3460 3458 3717 6774 6772 7297 3716 6775 2625 940 PMC8377458__F2 Narrative Review of the Renin-Angiotensin-Aldosterone System in the Placenta and Placental Bed of HIV Infected Women of African Ancestry with Preeclampsia 3786 3785 4513 PMC8378592__F3 Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways 3603 3952 4049 4050 613 6850 10913 929 7099 958 29760 27040 7189 7706 114609 7187 7186 695 472 331 4513 7412 4803 PMC8381052__F4 Autoantibody-Specific Signalling in Pemphigus 10399 387 5335 1828 55914 8036 PMC8381213__F2 Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense 6773 10379 4928 57506 3661 8772 PMC8381548__F1 Therapeutic strategies in METex14 skipping mutated non-small cell lung cancer 2885 3082 6714 2549 6774 PMC8382522__F9 Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/Beta-Catenin Signaling Pathway 3553 7124 1499 324 PMC8383741__F7 IP-10 Promotes Latent HIV Infection in Resting Memory CD4+ T Cells via LIMK-Cofilin Pathway 920 998 7852 3984 2833 PMC8386479__F7 Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming 4357 875 79587 847 PMC8387362__F1 Study workflow 676 672 675 5728 9611 9156 2068 79728 472 PMC8387852__F5 Gold nanoparticles enhance microRNA 31 detection in colon cancer cells after inhibition with chlorogenic acid 1081 581 6657 PMC8387860__F2 Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls 5163 572 6714 581 317 PMC8389007__F8 Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production 7099 3553 5027 114548 PMC8389562__F5 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer 8078 56998 867 100302155 574468 4609 2186 23476 7675 100422897 100302240 57646 PMC8392056__F1 Molecularly Targeted Therapies for Gastric Cancer. State of the Art 3082 1956 5163 2475 PMC8394255__F2 Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina 1499 6774 2638 5080 PMC8394439__F1 Microbiota-Associated Metabolites and Related Immunoregulation in Colorectal Cancer 50943 3586 50616 7124 920 2638 3902 4775 PMC8395072__F3 Transcriptomic Analysis Reveals Key Genes Involved in Oil and Linoleic Acid Biosynthesis during Artemisia sphaerocephala Seed Development 4018 95 1605 5091 PMC8395144__F1 An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches 9817 1728 2729 2730 5052 PMC8395387__F2 Pathophysiology of thrombosis in IBD 7035 7018 5340 11093 7450 5196 PMC8395571__F7 Pathway-targets analysis 3791 983 332 581 890 891 862 7153 1111 PMC8395582__F5 ErbB signaling pathway map 1950 367 685 9542 10718 145957 126669 2885 1398 867 2475 572 3725 4609 PMC8395918__F7 Physalin A, 13,14-Seco-16, 24-Cyclo-Steroid, Inhibits Stemness of Breast Cancer Cells by Regulation of Hedgehog Signaling Pathway and Yes-Associated Protein 1 (YAP1) 10413 6608 79923 PMC8396177__F1 Neutrophil Extracellular Traps (NETs) in Severe SARS-CoV-2 Lung Disease 7099 6714 4353 PMC8396474__F1 Redox Signaling and Sarcopenia: Searching for the Primary Suspect 2475 23411 23410 952 2308 2309 2152 PMC8401288__F1 Single LC-MS/MS Analysis to Quantify CoA Biosynthetic Intermediates and Short-Chain Acyl CoAs 79717 60490 80347 5471 95 PMC8402498__F10 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions 5728 23139 100187761 572 PMC8402548__F1 Analysis of Host Immunological Response of Adenovirus-Based COVID-19 Vaccines 7054 10297 3569 3586 PMC8403114__F2 Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis 3549 642658 6662 PMC8403526__F2 SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerance 3458 3558 2056 PMC8407980__F9 Alterations and Potential Roles of MCMs in Breast Cancer 472 545 51083 1674 5728 PMC8412938__F10 Summary model 9370 6387 56729 10438 155 11343 4280 1675 PMC8415109__F1 Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis 10494 4771 81788 57787 51701 983 9686 4485 9113 60485 387 7074 10664 558 4609 154796 595 332 5784 1499 647979 PMC8416371__F8 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis 6886 716 5901 1103 572 9118 759 PMC8417127__F2 Gut Microbiota in Lung Cancer: From Carcinogenesis to Immunotherapy 6364 1235 3383 PMC8417405__F2 Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation 3265 7248 7249 4193 5728 3479 472 545 PMC8417798__F9 Obesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3–SOCS3 Pathway 3717 6774 9021 65266 PMC8417882__F5 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges 83939 467 468 PMC8419056__F2 Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment 114548 3146 581 6774 56169 PMC8421037__F1 Mitosis by the Hippo pathway and YAP/TAZ 9113 26524 246184 324 10664 10494 60485 4485 7003 8463 7004 7005 1024 983 PMC8422077__F2 Depiction of genetic dependencies in cancer 27183 9525 1950 1956 673 PMC8422731__F2 STAT3 pathway as a molecular target for resveratrol in breast cancer treatment 6714 6774 595 25942 PMC8424144__F6 How Kcnma1 regulates bone formation through Wnt/Beta-catenin signaling 1499 324 860 7874 PMC8426673__F1 Lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses 59272 1636 6868 PMC8427239__F1 MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis: Implications in personalized medicine 90627 999 4609 4613 2308 199974 3977 5728 11072 PMC8428093__F3 Cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor 2919 9242 6469 6774 1499 8549 960 PMC8430321__F5 Network Pharmacology-Based Analysis on the Potential Biological Mechanisms of Sinisan Against Non-Alcoholic Fatty Liver Disease 7124 4060 5118 4015 PMC8430477__F4 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 27043 1687 23411 581 PMC8430477__F5 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 2879 23657 6520 PMC8430477__F7 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 5133 2919 1602 50943 920 84890 PMC8431402__F10 Comparison of the Effects of Resveratrol and Its Derivatives on the Radiation Response of MCF-7 Breast Cancer Cells 847 8772 581 PMC8431455__F5 Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast Yarrowia lipolytica 4191 2819 100996949 2203 48 6886 3417 3418 PMC8432624__F5 Protein Arginine Methyltransferase 5 Functions via Interacting Proteins 822 2475 6781 7422 5728 6662 2580 1956 1499 PMC8435904__F5 LncRNA GAS5 Competitively Combined With miR-21 Regulates PTEN and Influences EMT of Peritoneal Mesothelial Cells via Wnt/Beta-Catenin Signaling Pathway 60674 1499 5728 PMC8435905__F1 Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features 10858 3007 1593 9420 80270 10998 1962 3929 51302 23600 8309 1628 55744 27040 6476 PMC8436723__F4 Screening a Prognosis-Related Target Gene in Patients with HER-2-Positive Breast Cancer by Bioinformatics Analysis 4999 4171 1537 1869 6502 1017 990 5111 8317 10926 993 699 11043 9184 9126 999 PMC8440935__F4 Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients 3134 4548 4507 3201 191 7166 1644 4397 875 718 PMC8441765__F8 Schematic illustration of the proposed mechanisms for paclitaxel-induced growth inhibition in PC9 cells 596 637 3014 545 8772 993 1017 898 1950 1956 2475 PMC8443474__F1 Aryl hydrocarbon receptor in liver inflammation 196 9049 405 57491 1544 PMC8444451__F4 Identification of microRNAs and gene regulatory networks in cleft lip common in humans and mice 1856 2736 100126297 221833 93986 8626 5914 2304 1869 2104 8323 317 860 2290 27022 8313 89780 6469 6935 PMC8444957__F1 Advances in research on pharmacotherapy of sarcopenia 1636 367 59272 6714 3479 2475 2660 10468 90 4087 4089 PMC8447269__F1 Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia 6608 3549 6469 50846 5727 156 51684 PMC8447597__EV3 Drugs targeting SARS‐CoV‐2 and host protein interaction 10280 1719 338 1956 2064 7417 2066 513 506 539 11331 7416 145226 27330 657 1000 780 6844 10465 3482 56616 2 6720 6500 2324 5422 23649 5557 5558 6560 5831 7165 4598 29920 4524 2983 6524 117159 308 5110 6143 6147 51121 6134 2932 6187 6194 6652 6202 6203 6207 6218 1105 9833 5268 4036 10000 3312 80781 PMC8449320__F7 FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis 3725 6678 2191 PMC8450361__F1 Caloric Restriction May Help Delay the Onset of Frailty and Support Frailty Management 23411 3479 2475 PMC8450413__F4 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer 607 102 8756 8728 4609 PMC8451004__F4 Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer 613 6850 930 5879 5728 7249 572 4193 5934 4602 PMC8451139__F8 New Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling 572 581 9927 355 8772 PMC8455326__F4 Proposed gut–brain pathways mediating postoral sugar and fat appetition in mice 355 4922 641 PMC8456159__F7 Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus 8110 581 6774 57214 149233 PMC8456981__F1 ROCK2 controls the balance between pro-inflammatory and Treg cell subsets, regulates cytoskeletal dynamics and profibrotic gene expression and drives both chronic inflammation and fibrosis in cGVHD 3717 6774 9475 3662 4018 387 3718 50943 PMC8457632__F2 Antiviral Immune Evasion of SARS-CoV-2 4928 8480 6772 3661 6729 6728 10482 PMC8458633__F8 Network Pharmacology and Experimental Validation Reveal the Effects of Chidamide Combined With Aspirin on Acute Myeloid Leukemia-Myelodysplastic Syndrome Cells Through PI3K/AKT Pathway 4318 3265 890 6714 1017 836 1019 3320 PMC8458828__F6 Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma 196 7124 8205 PMC8460702__F5 Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2–YY1 signaling pathway 7832 7528 5105 PMC8463266__F8 Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NFKB pathway through microbiota–gut–brain axis 3929 7099 4615 4513 PMC8466575__F8 Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy 324 51669 7220 382 PMC8467684__F6 Identification and Characterization of Novel circRNAs Involved in Muscle Growth of Blunt Snout Bream (Megalobrama amblycephala) 326 1956 5295 5728 51074 2475 6009 7249 7248 842 836 572 PMC8468592__F2 Glucocorticoid and PD-1 Cross-Talk: Does the Immune System Become Confused? 324 5728 1017 2625 940 PMC8468925__F3 Targeting the p53 Pathway in CLL: State of the Art and Future Perspectives 472 545 7874 PMC8469001__F6 LRP1B: A Giant Lost in Cancer Translation 4035 351 53353 PMC8469949__F2 Actin Cytoskeleton Dynamics and Type I IFN-Mediated Immune Response: A Dangerous Liaison in Cancer? 57506 6624 29110 6041 2934 3661 3665 5879 64127 PMC8470622__F3 Epidermal Growth Factor Receptor Expression in the Corneal Epithelium 1950 7039 1839 685 367 PMC8471002__F4 Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models 3611 60485 4485 26524 9113 387 4087 4088 PMC8472533__F1 New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment 4485 60485 9113 PMC8473645__F8 Glutathione peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis 2879 7026 2944 PMC8476879__F3 Microglial Phenotypic Transition: Signaling Pathways and Influencing Modulators Involved in Regulation in Central Nervous System Diseases 4615 114548 4397 9021 4018 PMC8479196__F3 Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy 4025 100196919 2194 948 PMC8479832__F1 Purinergic signaling in the modulation of redox biology 84890 847 4353 PMC8481335__F2 Mitochondria in ferroptosis 9927 55669 1716 340061 5428 6648 115004 2879 1723 9131 9361 7019 3162 2271 51312 81894 5166 3418 9054 2395 23479 3658 27165 2242 51660 55847 493856 PMC8481641__F2 Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes 961 7535 325 3002 3458 664 140885 5551 PMC8482137__F3 Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups 595 999 3576 3630 5604 4609 5163 5295 5728 3725 4133 7157 PMC8482137__F5a Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups 3439 3447 958 1232 3454 3586 2672 3595 3725 3716 182 3569 5295 30009 6774 7040 7046 7048 PMC8482240__F3 Comprehensive Proteomic Analysis of Colon Cancer Tissue Revealed the Reason for the Worse Prognosis of Right-Sided Colon Cancer and Mucinous Colon Cancer at the Protein Level 117581 7291 2335 7448 6678 100506658 10747 1675 718 720 721 629 6935 5199 7046 727 3551 1147 7186 4217 730 4790 5604 5871 731 733 5606 3306 4149 PMC8483823__F4 Profile analysis of circular RNAs in cervical cancer 355 929 1610 23118 1616 7054 8195 4351 8288 4149 PMC8485144__F3 Molecular Profiling of Spermatozoa Reveals Correlations between Morphology and Gene Expression: A Novel Biomarker Panel for Male Infertility 116113 8187 57491 8912 146754 6790 5592 7015 2626 4053 56963 55743 55103 5071 23321 64094 23187 1284 55553 7008 23345 160777 10818 PMC8485521__F3 MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells 693219 494327 2885 407009 PMC8490884__F10 Neurodevelopmental Disorders in Patients With Complex Phenotypes and Potential Complex Genetic Basis Involving Non-Coding Genes, and Double CNVs 81614 8001 3632 2781 123606 10492 111 63874 54715 84811 6473 23191 55631 5789 PMC8491165__F1 Sphingolipid biosynthetic pathway leading to ceramide and sphingosine 1-phosphate (S1P) formation 6611 124976 53637 1901 1903 8698 9294 PMC8493690__F5 Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway 60485 4485 9113 26524 10413 PMC8494682__F1 Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway 79717 60490 5471 116150 2078 PMC8495383__F3 Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment 5284 7099 2023 5598 1998 4208 2064 PMC8497895__F2 Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer 324 941 942 1493 940 115004 472 545 PMC8498061__F2 Myricetin: A comprehensive review on its biological potentials 2475 1950 7290 6774 1956 PMC8501630__F5 Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors 2475 5091 9776 1977 3643 7248 6009 1975 7249 6010 6194 1999 PMC8503266__F2 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects 26524 9113 4485 60485 55233 5743 4513 5728 PMC8504146__F2 Non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential 1000 1956 2621 558 PMC8505060__F9 Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway 1392 1325 627 PMC8505728__F6 Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans 324 920 214 5817 933 965 948 914 958 940 1493 3683 923 29851 10666 5800 6693 7054 5788 3689 11201 6886 5426 952 941 942 10225 175 PMC8505796__F1 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer 216 5914 5915 PMC8505958__F2 Abnormal Airway Mucus Secretion Induced by Virus Infection 7039 3620 196 1956 3553 6667 7442 3566 6778 6774 PMC8506768__F4 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis 55509 3091 6199 5608 5606 5534 7097 6198 5530 4772 208 114609 1432 8503 8517 207 7099 4615 5533 5532 5291 3725 5595 5970 3551 3716 5295 6772 1147 148022 4793 5335 1950 116071 3845 5290 4792 5781 7535 3717 4794 3265 5588 915 916 5777 27040 3459 1459 919 PMC8506768__F6 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis 3082 1956 2272 5979 3718 5901 572 11186 581 51426 PMC8507004__F7 Promotion of chemerin in rat diabetic kidney disease through enhancement of TGFB1/Smads/CTGF pathway 9034 4087 4088 4089 PMC8507154__F2 Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches 2534 2668 2674 5979 6714 PMC8507550__F1 The Hedgehog Pathway in Cholangiocarcinoma 6608 2737 2736 51684 PMC8507550__F2 The Hedgehog Pathway in Cholangiocarcinoma 1000 6608 6657 79923 10769 PMC8507780__F10 Alterations in HLA Class I-Presented Immunopeptidome and Class I-Interactome upon Osimertinib Resistance in EGFR Mutant Lung Adenocarcinoma 23130 9776 2923 51752 6890 567 5698 5699 4012 79720 8675 811 PMC8508555__F4 Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential 2810 9817 4094 1728 PMC8508740__F1 New Fast Acting Glucagon for Recovery from Hypoglycemia, a Life-Threatening Situation: Nasal Powder and Injected Stable Solutions 847 5834 5277 PMC8509620__F8 Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway 4018 1902 9475 1019 595 1017 890 PMC8510628__F1 Formyl Peptide Receptors in Neurological Diseases via Regulating Inflammation 6714 301 3553 PMC8511501__F1 Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway 5781 2833 4155 6197 405 2241 5604 1843 729230 2539 196 5595 6347 3627 3579 9049 5801 5970 5778 3320 8654 2034 5770 3577 PMC8511527__F1 Endoplasmic Reticulum Quality Control in Immune Cells 22926 83939 468 7186 7494 PMC8514585__F2 PRMT5 in DNA damage response in prostate cancer 10419 7465 367 8607 5888 10635 5892 672 675 79840 7518 PMC8514698__F2 Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine 9776 407055 406948 406953 406982 406900 406899 494335 407014 10533 64422 9474 407011 407029 406952 406959 407040 9140 83734 22863 3920 406943 PMC8517597__F2 Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment 1513 55364 7124 3627 100187761 PMC8517756__F2 Endothelial dysfunction and COVID-19 (Review) 59272 1636 7124 PMC8517994__F2 MiRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer 285973 9709 7494 355 83939 PMC8522100__F2 Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing 4914 4916 238 673 5979 PMC8524440__F2 Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives 941 942 1493 940 100187761 PMC8524664__F10 Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3B signaling pathway 847 581 2932 PMC8524703__F1 Glioblastoma pharmacotherapy: A multifaceted perspective of conventional and emerging treatments (Review) 1956 5156 1029 1030 1031 4193 4763 5728 889 1019 1021 7157 4194 2475 100144748 5925 PMC8525369__F1 Gene Editing of Hematopoietic Stem Cells: Hopes and Hurdles Toward Clinical Translation 1234 2175 53335 1536 7454 17 PMC8526538__F8 Lysosomal-Associated Protein Transmembrane 5 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy 7805 5879 84366 PMC8526709__F3 KEGG enrichments of DEGs in protein-protein interaction network (PPI) 8074 5741 1839 846 2260 1958 387 5144 7421 1591 9247 9935 2625 6667 3727 4040 PMC8526866__F7 SUZ12 Loss Amplifies the Ras/ERK Pathway by Activating Adenylate Cyclase 1 in NF1-Associated Neurofibromas 5931 5928 2145 2146 8726 23512 107 PMC8526962__F5 Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway 2885 7039 1950 PMC8527892__F2 Plasmin Cascade Mediates Thrombotic Events in SARS-CoV-2 Infection via Complement and Platelet-Activating Systems 154 11037 3976 1839 3949 247 10376 84790 4051 7277 7846 10383 27289 8829 3569 5567 6278 6590 1437 7097 602 29899 2921 3371 2920 5743 718 5646 1440 6364 58191 6947 4792 11098 3656 8843 1476 6372 301 2919 629 978 1512 3383 1326 597 7078 5452 8870 942 6374 1890 5031 637 5724 6288 101 5328 8797 29760 3678 5271 54509 5329 10451 5055 1969 171177 2043 5327 4688 50486 64761 8581 85441 3459 6776 135228 2683 83666 10891 6772 9021 8876 5627 5155 9246 3437 2308 151636 2317 25939 684 4600 6678 2113 3570 4088 3690 54739 8519 10217 3434 4939 10561 3624 10379 4938 78990 10410 4599 3854 25984 4940 3665 7187 163351 9641 4050 3851 3866 3872 115362 8740 330 6700 7051 7128 6704 10318 192666 9119 6703 3713 PMC8531217__F12 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development 59272 7113 22937 PMC8532577__F2 Regulation on tumor metastasis by Raf kinase inhibitory protein: New insight with reactive oxygen species signaling 3082 1950 6714 6774 4851 PMC8533163__F8 Bacillus amyloliquefaciens SC06 Induced AKT–FOXO Signaling Pathway-Mediated Autophagy to Alleviate Oxidative Stress in IPEC-J2 Cells 581 596 2309 9140 9474 22863 23411 PMC8533248__F2 Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs 4040 4041 3597 3716 1499 9314 4089 4088 4087 4092 1277 1281 4312 10454 2475 PMC8533259__F3 Coordination of RNA Processing Regulation by Signal Transduction Pathways 10973 4193 545 PMC8533529__F2 Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution 4837 10135 23098 PMC8533565__F1 Virus-Induced Tumorigenesis and IFN System 115004 3661 3665 338376 7187 5979 162394 7099 7297 3716 6772 6774 7189 6773 3654 4615 51135 51284 54106 1636 7098 2475 1399 PMC8534027__F2 Roles of Diacylglycerol Kinase A in Cancer Cell Proliferation and Apoptosis 1606 387 2475 PMC8534108__F1 Metabolomic Profiling in Renal Cell Carcinoma Patients: News and Views 5163 2475 596 581 PMC8535522__F1 Development of New Cancer Treatment by Identifying and Focusing the Genetic Mutations or Altered Expression in Gynecologic Cancers 5728 4193 7157 983 1956 2475 7465 545 472 675 672 PMC8536449__F9 GNG4 Promotes Tumor Progression in Colorectal Cancer 930 5341 5266 572 51083 2475 4703 4609 1990 PMC8536789__AF1 Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease 8694 3920 468 PMC8537064__F1 Molecular Mechanisms of the SLC13A5 Gene Transcription 284111 23152 47 2475 PMC8538681__F1 Nucleotide Pool Imbalance and Antibody Gene Diversification 84890 100 4860 4693 25939 PMC8540846__F1 Molecular Targets and Promising Therapeutics of Triple-Negative Breast Cancer 5728 2475 79728 675 672 2152 1956 1846 367 PMC8540886__F2 Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment 355 3002 5551 5552 324 3902 942 941 940 PMC8541427__F2 Genetics of Diabetes: What We Can Learn from Drosophila 5728 5163 9882 PMC8541427__F4 Genetics of Diabetes: What We Can Learn from Drosophila 5728 5163 7248 7249 6009 PMC8544609__F2 Hormetic ER stress signaling elucidated in HSCs 93129 84876 80228 6786 57620 6400 717 22926 7494 65992 165721 7054 861 468 1998 PMC8546956__F7 Comparative phenotypic and transcriptomic analyses unravel conserved and distinct mechanisms underlying shade avoidance syndrome in Brassicaceae vegetables 1431 9365 5091 27159 3791 PMC8548662__F3 Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma 4851 23462 6657 PMC8548714__F1 Current Application and Future Prospects of Astragalus Polysaccharide Combined With Cancer Immunotherapy: A Review 920 6367 9242 7045 3458 6772 6774 238 6098 PMC8549629__F8 Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro 6850 7074 7204 5879 695 5058 PMC8549681__F1 Glucocorticoids induce osteonecrosis of the femoral head through the Hippo signaling pathway 860 4485 9113 26524 PMC8549879__F1 Hepatic LC3 II/I Ratio Is Not Modulated in Exercised Mice 9776 9474 9140 22863 596 10533 64422 PMC8550759__F8 RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy 7474 4920 4919 54894 673 PMC8550885__F3 Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan 7099 324 51311 51284 54106 2475 941 942 940 PMC8552808__F3 Treatment of COVID-19 with Traditional Chinese Medicine: What Herbs Can Help Win the Battle with SARS-CoV-2? 324 7124 920 PMC8553822__F2 TLR signal transduction 3665 3654 5132 7096 7097 10333 81793 51311 51135 3659 54106 51284 3663 3656 7189 7099 114609 4118 4615 23118 257397 10454 8737 3661 7098 7187 29110 10010 PMC8557524__F3 Targeting CD47 for cancer immunotherapy 140885 961 7454 PMC8558658__F7 Hey1 promotes migration and invasion of melanoma cells via GRB2/PI3K/AKT signaling cascade 2885 2549 23462 PMC8558661__F10 Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-Alpha-activated COX-2-cPLA2-PGE2 Pathway 581 2638 1178 10533 9474 PMC8560683__F1 Klotho as Potential Autophagy Regulator and Therapeutic Target 596 3479 2475 260431 PMC8560834__F8 Incorporating Transcriptomic-Metabolomic analysis reveal the effect of ultrasound on ethanol production in Saccharomyces Cerevisiae 157739 5132 4191 PMC8560908__F2 The interplay between JAK/STAT signaling and ARTD family members 151636 54625 83666 6772 57097 1356 142 3066 8841 PMC8561165__F1 Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease 4283 8942 8564 5212 PMC8563895__F7 B2-adrenergic receptor regulates ER-mitochondria contacts 90550 64423 998 PMC8564336__F1 Biological and clinical implications of metastasis‐associated circular RNAs in oesophageal squamous cell carcinoma 7473 1499 693184 999 55740 2932 8204 1000 5728 PMC8564965__F2 Fibroblast growth factor receptor fusions in cancer: opportunities and challenges 6774 10818 2549 PMC8565990__F1 BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View 695 973 974 4067 6850 29760 5336 930 2475 PMC8566112__F4 Peroxisomal biogenesis pathway 9409 8504 5824 5194 5195 5830 5190 5193 5192 PMC8566418__F2 Estetrol and Mammary Gland: Friends or Foes? 5241 9687 7031 6714 7018 25987 26353 PMC8567306__F5 Clinical translation of immunomodulatory therapeutics 3558 920 3716 3718 PMC8569219__F6 Studying the tumor microenvironment and engineering of tumor organoids 7157 3845 324 4089 5290 673 26585 1029 2638 999 387 5728 4763 8314 7018 PMC8569258__F2 Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects 3630 3643 2194 2475 6722 2885 8717 7186 581 596 PMC8569703__F1 Contextual Essentiality of Mitochondrial Genes in Cancer 5250 6647 27068 1723 4695 2395 27235 598 6391 23479 2242 7386 54205 5091 1431 116228 64968 131474 2671 7019 64216 5625 10452 51499 1854 114971 3954 PMC8571914__F2 S1P Signaling Pathways in Pathogenesis of Type 2 Diabetes 6010 124976 7186 PMC8572812__F1 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases 5728 3643 5163 3716 10399 2475 6774 PMC8573605__F1 Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data 5970 602 5971 920 5132 PMC8574122__F1 PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19 5728 5163 7249 7248 6009 64223 64798 6446 PMC8576642__F7 Berberine attenuates atherosclerotic lesions and hepatic steatosis in ApoE-/- mice by down-regulating PCSK9 via ERK1/2 pathway 7124 7412 3383 3553 2475 23411 50507 847 19 255738 PMC8576660__F2 Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapy 4609 2932 6714 2887 2885 6774 PMC8580862__F9 Immune-Related Molecular Profiling of Thymoma With Myasthenia Gravis 1874 6502 5000 4087 4088 4089 1017 4193 5111 1537 1022 8318 924 993 699 29116 4632 9184 9126 6770 991 999 PMC8580935__F1 Palbociclib as an early-line treatment for Japanese patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer: a review of clinical trial and real-world data 8205 2475 8405 PMC8581356__F1 Immune Evasion Mechanism and AXL 6347 6348 6351 6352 558 10663 1493 50943 8205 8651 9021 PMC8581865__F6 Dura cells in the etiopathogenesis of Crouzon syndrome: the effects of FGFR2 mutations in the dura cells on the proliferation of osteoblasts through the hippo/YAP mediated transcriptional regulation pathway 9113 26524 4485 207 5291 PMC8582326__F2 Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury 6010 10013 23122 PMC8582658__F5 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions 4040 4041 1499 324 PMC8582887__F2 PI3KD Inhibitors as Immunomodulatory Agents for the Treatment of Lymphoma Patients 6194 60468 2308 3458 5728 50943 6402 1236 PMC8583797__F9 Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor 10507 2064 387 10451 6093 3667 3480 PMC8583941__F2 Deacetylation of Transcription Factors in Carcinogenesis 23411 581 23410 6502 5728 51547 4193 51548 22933 PMC8584317__F3 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis 7248 2475 1977 PMC8584803__F1 Biochemical Markers for the Diagnosis of Mitochondrial Fatty Acid Oxidation Diseases 1376 717 718 PMC8585009__F5 Diagram depicting the 2 branches of the fat remodeling program controlled by neuronal activation of Hsf-1 51327 338386 7018 PMC8587556__F4 Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease 1499 4040 4041 324 2932 4920 4919 6259 107966124 PMC8588641__F7 Umbilical cord blood plasma-derived exosomes as a novel therapy to reverse liver fibrosis 4087 4088 3397 PMC8591777__F5 Application of Lipidomics for Assessing Tissue Lipid Profiles of Patients With Squamous Cell Carcinoma 55364 5091 4099 2821 2020 2019 PMC8593035__F7 Mechanism of NUSAP1 promoting DNA repair process by binding with RAD51 4193 472 675 5888 51203 PMC8593816__F5 Clinical Significance of Screening Differential Metabolites in Ovarian Cancer Tissue and Ascites by LC/MS 1806 1807 55748 84735 9415 10965 2194 2180 240 2678 120227 1594 34 1581 1583 PMC8598308__F5 Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients 59341 1268 11343 222236 2166 747 57406 22999 2911 3708 PMC8599584__F6 KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway 1950 1956 998 56992 PMC8599883__F1 Zinc in female reproduction 324 891 983 2827 2835 994 5595 5594 5139 4342 4882 1956 4087 4088 4880 PMC8600110__F1 Receptor-Mediated NETosis on Neutrophils 3146 51311 54106 51284 7097 10333 7099 114548 64127 4353 6850 3577 59272 7226 7113 PMC8600921__F1 Cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies 3002 55876 3001 7097 4615 3146 7099 958 114548 9447 3553 79792 PMC8602198__F2 Contribution of miRNAs in the Pathogenesis of Breast Cancer 9776 7405 2475 3146 596 693152 9140 9474 10533 83734 64422 8878 693235 6295 9342 55014 PMC8602894__F7 Hsa_circRNA_103124 Upregulation in Crohn’s Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway 208 1017 7248 PMC8607372__F2 Cytosolic and nuclear recognition of virus and viral evasion 197358 3428 115004 29110 3661 11277 1660 170506 4615 834 PMC8607372__F3 Cytosolic and nuclear recognition of virus and viral evasion 55601 7706 79132 1283 57506 29110 3661 201292 PMC8607431__F7 Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy 673 5728 2475 5163 6714 10413 PMC8609049__F1 “Aerobic glycolytic imaging” of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging 27040 2744 3099 3939 2475 5163 4548 PMC8609314__F6 Activation of PTH1R alleviates epididymitis and orchitis through Gq and Beta-arrestin-1 pathways 5745 3569 7124 3627 PMC8611230__F1 Melanoma susceptibility: an update on genetic and epigenetic findings 1019 1029 1021 472 8314 65057 25913 54386 PMC8612614__F3 Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench 6722 1401 2668 6285 652 PMC8613079__F1 Complement in metabolic disease: metaflammation and a two-edged sword 718 717 727 PMC8615162__F2 Coenzyme Q at the Hinge of Health and Metabolic Diseases 55129 55486 673 2110 1723 3949 2395 118987 55669 9927 3156 4358 5428 8803 PMC8615223__F6 Immunomodulatory Effects of a Concoction of Natural Bioactive Compounds—Mechanistic Insights 5728 2932 2475 7099 9817 PMC8615487__F2 An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes 54790 114548 3603 23476 5970 7494 4615 6774 23410 22933 1999 57787 10628 7351 PMC8615581__F2 Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies 2879 3652 2182 10162 9817 PMC8615888__F1 STING Signaling and Skin Cancers 6657 79671 115004 3661 PMC8616011__F3 Immunotherapy in Breast Cancer: When, How, and What Challenges? 6347 567 8205 PMC8616143__F1 Unfolded Protein Response as a Guardian of the Secretory Pathway 22926 7494 83939 468 PMC8616422__F2 Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease 1582 1581 1593 9420 4280 PMC8616517__F3 Kinase Inhibitors’ Effects on Innate Immunity in Solid Cancers 940 324 8205 PMC8616591__F2 Glypican-1 in regulating multiple cellular signaling pathways 100187761 4040 4041 1499 84133 54894 2817 10090 55366 8549 59352 PMC8617922__F1 Pentoxifylline as a Potential Adjuvant Therapy for COVID-19: Impeding the Burden of the Cytokine Storm 7341 3569 9021 PMC8618298__F4 Current Status of Photodynamic Diagnosis for Gastric Tumors 1371 5498 2235 9429 10058 210 3145 7390 7389 PMC8618532__F2 Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function 3565 2475 23410 10538 23411 PMC8622675__F2 Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis? 1616 6714 4485 9113 26524 PMC8623349__F7 Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis 4879 4878 5350 100187761 5587 3066 1906 7124 1636 4609 1536 3551 5607 5598 5728 387 4149 6885 5606 5608 9261 5609 6416 85451 5747 1499 93649 1489 3976 3479 7249 1386 3725 1978 23209 4625 1827 3717 PMC8624111__F10 Design, Synthesis and Evaluation of Novel Derivatives of Curcuminoids with Cytotoxicity 1869 4609 472 545 4193 94005 1017 7249 5728 914 637 317 64326 842 836 2475 PMC8625071__F1 Natural Products for Pancreatic Cancer Treatment: From Traditional Medicine to Modern Drug Discovery 2146 2475 5728 581 331 7454 6774 637 PMC8625973__F1 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy 4771 83737 864 60485 4485 9113 26524 387 7408 154796 PMC8625973__F2 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy 4485 9113 26524 23261 7030 4771 PMC8625973__F6 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy 60485 4485 55841 9113 26524 23558 PMC8625973__F8 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy 23558 7391 26524 55841 PMC8627910__F2 Fragment of the gene network, containing genes associated with PIN1 and genes related to the auxin signaling pathway 1314 5300 4035 PMC8631411__F2 Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in cardiovascular disease 9447 114548 79792 PMC8632052__F5 Chronic Circadian Rhythm Disturbance Accelerates Knee Cartilage Degeneration in Rats Accompanied by the Activation of the Canonical Wnt/Beta-Catenin Signaling Pathway 1499 406 3553 PMC8634166__F8 Uncovering Bupi Yishen Formula Pharmacological Mechanisms Against Chronic Kidney Disease by Network Pharmacology and Experimental Validation 7099 4615 3603 3099 PMC8634263__F9 Cyclic Mechanical Strain Regulates Osteoblastic Differentiation of Mesenchymal Stem Cells on TiO2 Nanotubes Through GCN5 and Wnt/Beta-Catenin 860 80326 7475 7471 324 8313 1499 PMC8634264__F2 Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects 9817 59272 7113 PMC8635790__F5 Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease 4891 30061 2182 23305 2512 22928 875 51540 4524 PMC8637577__F2 Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance 51228 64781 6611 2592 4026 1674 124976 100188863 PMC8638425__F4 Insights into high-risk multiple myeloma from an analysis of the role of PHF19 in cancer 5972 26147 23512 2145 2146 8726 1028 1026 3091 4170 64077 54585 9961 596 4609 1958 PMC8638743__F1 Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses 7249 5728 2475 253260 64798 7248 6009 5163 PMC8640016__F8 FUT8 negatively regulates NFKB2 signaling by blocking the activation of TNFR 8772 4791 597 7124 2530 PMC8640358__F5 Network Pharmacology and Molecular Docking–Based Investigation: Prunus mume Against Colorectal Cancer via Silencing RelA Expression 4792 1950 3551 1543 891 1869 836 653361 5970 7422 857 5578 581 983 153 4313 154 1281 842 598 7153 3552 2950 5530 3383 596 5328 2920 4314 5579 6256 2946 11200 1544 5733 2065 4312 5743 4318 367 1956 3091 2002 5599 4609 2353 1576 595 332 3627 841 1026 PMC8645129__F8 Development and characterization of efficient xylose utilization strains of Zymomonas mobilis 4094 6101 5978 PMC8648396__F10 Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine Beta-coronavirus-induced neuroinflammation 11315 5970 3162 7076 PMC8650046__F3 Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator 3459 8569 8503 7099 5210 7037 3643 3939 1387 112399 7428 5209 2872 3091 3162 5291 7422 2033 5594 1026 5970 5295 6199 2321 207 1027 8453 596 406947 9470 10000 4790 3569 226 5163 4846 1956 6774 3099 5230 7076 285 1977 5054 5578 5335 6513 3460 PMC8654699__F6 Targeting SOS1 overcomes imatinib resistance with BCR-ABL independence through uptake transporter SLC22A4 in CML 5894 6654 6583 PMC8656574__F1 Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application 1050 596 9113 283120 100874054 2146 10413 PMC8657787__F3 Protein Tyrosine Phosphatases: Mechanisms in Cancer 2885 1445 2549 5782 5163 5728 PMC86592__F9 LPS-induced signaling pathways leading to activation of transcription and spreading 3929 929 4615 7189 PMC8661833__F2 Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity 367 55364 1636 2717 2239 84839 7098 6403 PMC8662531__F1 CGAS-STING signaling pathway 11277 115004 3661 29110 PMC8664902__F5 Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis 2103 2272 401237 6098 4773 6948 5591 10020 1016 4485 103 6586 6453 55054 1870 4983 64478 5144 864 171389 1072 2775 1759 3824 9628 4843 6597 125893 4482 546 7991 283120 57492 6775 10148 6899 10010 1667 5970 367 2893 51741 5071 9524 29117 10533 4803 149041 7186 23556 374 2934 1387 7450 1201 4313 8766 152330 1740 1588 1540 3371 79868 10743 6531 51596 54332 3832 6794 5252 11343 6134 23261 7049 3910 814 57553 5581 5590 2895 PMC8664902__F6 Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis 116841 47 3339 6794 9962 3785 1000 4893 2013 23239 406969 5820 100302175 2879 4052 10577 2350 135 5796 5467 596 2070 23523 50859 4851 5802 3091 1520 7349 23411 2308 4880 5071 2253 5045 11314 6745 2321 7704 6613 4481 4681 7307 8570 3778 7553 10010 171389 9308 4772 610 3786 6575 6586 6256 773 4137 693180 6241 693158 471 6899 114609 PMC8667344__F1 Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor 324 2625 50943 3568 3662 PMC8667473__F2 Review: The Role of Wnt/Beta-Catenin Signalling in Neural Crest Development in Zebrafish 22943 324 4040 4041 2932 PMC8668986__F10 Metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer 367 10397 6774 7297 PMC8669610__F1 TGFB Signaling and Resistance to Cancer Therapy 6010 7189 9618 2885 2475 PMC8670090__F1 Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma 596 60673 22863 8408 9776 64422 10533 83734 9474 9140 PMC8673831__F3 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes 7124 406938 5728 3667 3643 2475 100422833 2944 57761 PMC8674203__F2 TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers 123036 238 4609 572 5728 64326 PMC8674309__F2 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment 941 942 3458 3600 6352 6347 920 PMC8675148__F2 Exploiting natural antiviral immunity for the control of pandemics: Lessons from Covid-19 4615 57506 29110 3661 5132 7297 3454 3455 3569 3553 6347 6354 729230 PMC8677728__F2 Targeting PI3K/Akt signal transduction for cancer therapy 4193 7249 5163 PMC8684645__F2 NK cell upraise in the dark world of cancer stem cells 3600 3458 947 952 10219 7124 PMC8686226__F3 Developing landscape of combinatorial therapies of immune checkpoint blockade with DNA damage repair inhibitors for the treatment of breast and ovarian cancers 115004 29110 3661 6348 472 545 1493 672 3458 PMC8687455__F7 Analysis of Wheat Wax Regulation Mechanism by Liposome and Transcriptome 11343 95 1606 7038 PMC8687818__F5 Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation 836 581 7157 6256 2353 367 2717 5970 596 3643 4609 1017 1956 4843 6347 3725 1950 6401 5328 PMC8687818__F8 Anticancer Action of Xiaoxianxiong Tang in Non-Small Cell Lung Cancer by Pharmacological Analysis and Experimental Validation 1950 1129 4609 5970 836 842 3725 1017 890 PMC8691188__F1 Mathematical Model to Characterize the Role of Light Adaptation in Mammalian Circadian Clock 6097 150094 619537 5187 1407 1408 8864 406 9575 PMC8692699__F2 Roles of long non-coding RNAs in lung cancer 401 6667 100124700 3198 1759 5170 PMC8692837__F3 Mechanobiological Implications of Cancer Progression in Space 1499 6925 51176 4040 4041 324 2048 2049 PMC8693975__F1 Modeling and analysis of the macronutrient signaling network in budding yeast 1998 4553 83939 PMC8696122__F8 Brain and Pituitary Transcriptome Analyses Reveal the Differential Regulation of Reproduction-Related LncRNAs and mRNAs in Cynoglossus semilaevis 2798 4313 3972 2488 1839 2885 1956 PMC8696218__F4 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 4609 595 650 7124 4318 3845 4055 5971 7015 6363 3383 PMC8696218__F1 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 8549 8312 2932 1499 324 23043 4609 PMC8696218__F3 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 6608 4609 6615 891 PMC8697849__F6 Combined Oral Contraceptives and Venous Thromboembolism: Review and Perspective to Mitigate the Risk 6714 6722 2002 857 PMC8698071__F10 Resveratrol Relieved Acute Liver Damage in Ducks (Anas platyrhynchos) Induced by AFB1 via Modulation of Apoptosis and Nrf2 Signaling Pathways 23411 581 2729 2730 1728 847 9817 PMC8698579__F1 YAP/Hippo Pathway and Cancer Immunity: It Takes Two to Tango 920 930 8463 6374 4615 7004 3579 5728 1493 942 PMC8699052__F2 NRF2 in Mycobacterial Infection 2810 6772 729230 PMC8699276__F1 Targeting KRAS in NSCLC: Old Failures and New Options for “Non-G12c” Patients 5900 6017 5728 2885 7074 5879 5163 5058 2475 4015 PMC8699295__F3 TRPM7 Ion Channel: Oncogenic Roles and Therapeutic Potential in Breast Cancer 1956 1950 999 54822 6659 2303 6935 PMC8699297__F2 Impact of a Faulty Germinal Center Reaction on the Pathogenesis of Primary Diffuse Large B Cell Lymphoma of the Central Nervous System 613 973 695 29760 867 84433 8915 10892 79718 1029 4609 5079 639 4615 PMC8699303__F6 Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas 1956 5728 2475 3845 9610 23462 23493 11319 999 PMC8699427__F2 Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease 8864 5187 3606 PMC8699445__F1 Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer 283871 367 5888 79728 675 472 PMC8699554__F1 COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges 324 920 3458 1401 PMC8699560__F1 Enhancing Therapeutic Approaches for Melanoma Patients Targeting Epigenetic Modifiers 5728 10013 1493 7124 PMC8700603__F3 Association between Altered Oncogenic Signaling Pathways and Overall Survival of Patients with Metastatic Colorectal Cancer 54894 1956 2260 5979 23269 6423 6422 6425 6424 2932 324 83463 10608 4084 867 5879 22877 5781 4149 2064 2263 4613 6098 4609 6945 1499 6932 83439 2065 4610 4335 2261 238 54206 3845 5594 8313 8312 7089 7090 7091 7088 369 27121 22943 27123 27122 2066 2264 2322 6654 3265 5604 673 6794 253260 3815 4914 4763 5728 4087 208 7248 7249 6009 5156 3480 4915 5921 6016 4089 93 PMC8700745__F3 Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid–Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario 5741 5744 5746 6522 5212 115111 115019 6750 495 140805 5091 PMC8704918__F2 CWI Pathway: A Versatile Toolbox to Arrest Cell-Cycle Progression 6054 4360 892 PMC8705098__F2 Complement System in Alzheimer’s Disease 721 718 100187761 PMC8706759__F3 Targeting DNA repair pathway in cancer: Mechanisms and clinical application 3661 472 545 115004 PMC8708574__F4 CXCL13 in Cancer and Other Diseases: Biological Functions, Clinical Significance, and Therapeutic Opportunities 1000 999 10563 2931 643 572 6714 1794 PMC8708596__F4 An Insight on Novel Molecular Pathways in Metastatic Prostate Cancer: A Focus on DDR, MSI and AKT 2885 6009 5728 5163 7249 7248 PMC8709142__F1 Beneficial Properties of Bromelain 2021 572 581 892 PMC8712267__F5 Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19 325 5265 335 5880 5950 7412 3383 1401 2153 6291 7276 6289 213 336 2512 7430 183 3273 5005 60 2158 2266 1950 2335 5004 4478 722 3240 7414 4637 725 72 3929 6386 1903 10268 6010 397 6383 55970 2787 8976 1000 2782 84699 7422 5159 7049 5216 998 10672 2923 2778 5898 22800 391 4638 2767 4627 5155 4883 30833 5908 PMC8713033__F6 Function of CARMIL1 in IL-1 Signaling 55604 4615 3656 3654 6714 5548 PMC8714827__F2 EGFR-Dependent Extracellular Matrix Protein Interactions Might Light a Candle in Cell Behavior of Non-Small Cell Lung Cancer 10516 1950 3479 1956 2475 7448 2192 PMC8715196__F13 KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin Pathway 7403 100187761 999 PMC8716792__F3 Ferroptosis Signaling and Regulators in Atherosclerosis 27165 6541 4485 9113 26524 50507 PMC8717028__F1 Nuclear receptors modulate inflammasomes in the pathophysiology and treatment of major depressive disorder 196 5468 79792 3553 PMC8718071__F8 Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome 8213 1593 9420 570 2264 762 PMC8718573__F3 Abnormal sialylation and fucosylation of saliva glycoproteins: Characteristics of lung cancer-specific biomarkers 2520 2026 945 94025 4058 29126 301 5111 1956 567 177 796 1948 5327 2064 4582 2099 3815 174 595 10406 3952 51378 1113 260425 7225 8870 2475 PMC8721012__F5 New Antitumor Direction: Tumor-Specific Endothelial Cells 6347 6367 100379198 116835 2475 2932 2247 PMC8723792__F3 Translational science of cancers with SWI/SNF complex aberrations 545 4193 1021 1019 2260 2146 6595 6597 57492 65980 PMC8727999__F2 Concepts in Multifactorial Etiology of Developmental Disorders: Gene-Gene and Gene-Environment Interactions in Holoprosencephaly 4838 7050 7546 4087 4088 8928 2619 50937 6469 57758 5727 4036 2736 6496 7289 26123 26160 27148 54903 2260 28514 PMC8733431__F7 NETME: on-the-fly knowledge network construction from biomedical literature 6868 9429 819 7040 6670 9122 29072 960 6275 3606 4312 374 999 5241 5595 1435 5228 4790 5594 3479 5340 1956 1950 5747 28985 682 51135 4313 8936 207 4323 81704 5478 407004 3569 6010 5879 5290 4609 6714 6667 302 5111 8600 7422 3162 4318 6774 56731 PMC8733588__F2 What Happens to the Immune Microenvironment After PD-1 Inhibitor Therapy? 6348 6347 3902 PMC8734057__SF1 Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19 59272 6868 7124 PMC8734249__F2 CD70-CD27 axis in oncology: the new kids on the block 939 970 960 6657 7431 PMC8739690__F5 Transcriptomics analysis reveals the signal transduction mechanism of brassinolides in tea leaves and its regulation on the growth and development of Camellia sinensis 51411 578 2000 55677 PMC8739787__F2 HIF-1A Is a Rational Target for Future Ovarian Cancer Therapies 102723099 6774 84677 23235 4885 7428 2475 581 5211 4313 4318 PMC8740130__F6 Differentially Expressed lncRNAs Related to the Development of Abdominal Fat in Gushi Chickens and Their Interaction Regulatory Network 9370 2170 4023 81616 2182 6476 PMC8742179__F6 ZNF292 suppresses proliferation of ESCC cells through ZNF292/SKP2/P27 signaling axis 23036 9978 8454 6500 6502 PMC8743650__F1 Mitochondrial dynamics and diabetic kidney disease: Missing pieces for the puzzle of therapeutic approaches 5908 6093 56947 3164 1843 55586 65018 9927 55669 PMC8744248__F3 Recent advances in systemic therapy for hepatocellular carcinoma 325 324 940 8205 PMC8745708__F4 Neurofibromatosis Type 1 Gene Alterations Define Specific Features of a Subset of Glioblastomas 4763 5879 2475 8061 PMC8747764__F7 TPMT mRNA Expression: A Novel Prognostic Biomarker for Patients with Colon Cancer by Bioinformatics Analysis 9060 7263 4717 4706 355 1347 4729 4722 23474 10380 4719 5663 6945 840 836 4035 1329 3339 91860 29796 2271 4190 2335 7423 9900 4700 6392 3419 4199 7059 3678 4200 3915 8801 1737 1311 3655 1292 3417 84693 26275 3480 103910 7058 594 10398 3099 9945 64841 5159 87 2316 7094 54187 5238 55862 51167 2762 8790 2673 PMC8749860__F1 BRCA1 and Metastasis: Outcome of Defective DNA Repair 672 79728 675 472 5888 PMC8750186__F4 mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells 23532 5684 5719 5691 5694 2271 5925 1871 1874 7027 7029 PMC8750350__F1 Cell Death in Hepatocellular Carcinoma: Pathogenesis and Therapeutic Opportunities 8737 8717 7186 7124 596 355 8772 841 836 11035 197259 PMC8750789__F2 AUTS2 Gene: Keys to Understanding the Pathogenesis of Neurodevelopmental Disorders 26053 5879 63916 10336 84333 998 8869 775 816 266727 PMC8750957__F2 TNF-Induced Osteoclast Differentiation 7186 7189 5970 7187 5971 PMC8753521__F5 Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer 2475 5728 3146 4322 6010 7422 5925 8473 6262 51660 2730 51701 79602 2729 51094 7852 6774 23411 PMC8755460__F3 K63 ubiquitination in immune signaling 7186 7189 84166 79671 3665 8737 7187 115004 3661 57506 29110 91662 197358 114548 50943 81858 613 PMC8762210__F10 High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer 1311 284 5156 5159 207 5728 8231 1385 842 5527 5516 5521 1129 2790 2022 2784 55970 146850 4600 10000 2264 3718 2932 6247 7157 5154 4915 PMC8764238__F1 Molecular Mechanism of Puerarin Against Diabetes and its Complications 1499 6774 3717 2308 PMC8765442__F2 Heart Failure with Targeted Cancer Therapies: Mechanisms and Cardioprotection 5979 2322 1636 PMC8766339__F7 Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab 5728 2475 382 1499 57105 7015 2776 6774 7204 6010 10413 163859 23451 9113 26524 1964 154796 PMC8766720__F6 MiR-27a-3p Targets GLP1R to Regulate Differentiation, Autophagy, and Release of Inflammatory Factors in Pre-Osteoblasts via the AMPK Signaling Pathway 2740 860 9474 PMC8767413__F4 Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence 847 1051 4312 1950 PMC8773595__F1 Clinical Significance of the Duality of Wnt/Beta-Catenin Signaling in Human Hepatocellular Carcinoma 619501 1499 3172 2305 999 PMC8773784__F2 Nephropathic Cystinosis: Pathogenic Roles of Inflammation and Potential for New Therapies 6374 55655 114548 3553 PMC8773933__F2 Bcl-2 Family Proteins in Estrogen Receptor-Positive Breast Cancer and Their Implications in Endocrine Therapy 7018 6667 6714 PMC8774167__F1 Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance 2475 10533 64422 PMC8777575__F3 Gold complex auranofin: new perspectives for cancer therapy 324 581 3146 PMC8778098__F1 Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors 83939 3654 51135 841 7189 115004 3661 PMC8778800__F1 FGFR Pathway Inhibition in Gastric Cancer: The Golden Era of an Old Target? 3552 10818 2885 2549 5290 2475 PMC8779408__F2 Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development 57650 5347 4751 23177 PMC8781990__F5 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host 252842 4953 140805 54826 28964 351 PMC8786725__F1 Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms 7018 771 1958 PMC8787342__F1 Activated Macrophage – A Tough Fortress for Virus Invasion: How Viruses Strike Back 3661 57506 3665 23650 115004 4615 7097 54106 7124 3569 3576 6347 942 941 51284 7099 7098 PMC8789910__F7 Illustration of proposed mechanism 56623 5879 998 6790 10013 PMC8792742__F2 Inflammasome Activation in Pulmonary Arterial Hypertension 7099 3553 79792 3146 PMC8795890__F2 Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration 571 5728 6662 572 581 4434 4314 114548 3603 PMC8797306__F2 Screening and verifying key genes with poor prognosis in colon cancer through bioinformatics analysis 4999 5000 5001 1874 4089 1017 6502 1022 10926 993 9184 9126 324 PMC8797391__F9 Bioinformatics analysis of BUB1 expression and gene regulation network in lung adenocarcinoma 7939 4118 51083 2241 PMC8797453__F5 KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer 3845 7531 4482 PMC8798237__F4 Key genes involved in cell cycle arrest and DNA damage repair identified in anaplastic thyroid carcinoma using integrated bioinformatics analysis 4609 472 545 4193 94005 84883 1017 100996569 5728 637 1537 836 PMC8800007__F3 Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair 142 22880 55226 581 23411 PMC8800112__F3 New blood-based RNA signature (R9), for monitoring effectiveness of tuberculosis treatment in a South Indian longitudinal cohort 351 6622 116071 604 23321 9021 4318 29126 306 6382 5447 7124 85451 920 PMC8800599__F1 Oxidative Stress Signaling Mediated Pathogenesis of Diabetic Cardiomyopathy 3550 114548 9817 PMC8804151__F1 Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases 4200 4199 8205 11319 51604 5281 PMC8804296__F1 Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis 114548 79792 3553 7124 PMC8804886__F5 mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion 657 650 4090 4086 3399 3397 3398 4091 100188776 324 2932 7248 5728 6009 2475 253260 79923 6657 PMC8807040__F8 Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway 6774 3717 581 1021 1019 PMC8807551__F7 FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway 581 1956 2475 PMC8810962__F4 Estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet 140679 2560 2562 2555 2563 6538 2556 2566 29979 2557 2561 55879 PMC8811214__F2 Cross-Talk Between EGFR and E-Cadherin 1956 1958 1499 4318 4313 387 1950 26953 6774 PMC8811422__F19 Chinese Herbal Formula Ruyan Neixiao Cream Inhibits Angiogenesis of Precancerous Breast Lesions via Regulation of Ras/Raf/MEK/ERK Signaling Pathway 3265 8434 7078 PMC8812242__F6 Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction 8066 10766 7054 175 4118 PMC8814460__F1 Inflammation and Myeloid Cells in Cancer Progression and Metastasis 6348 3579 2919 2920 7124 941 942 8205 6361 6362 6369 90865 9332 6387 911 945 9656 5132 PMC8814522__F4 Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis 10661 10767 53335 4602 383 384 PMC8814716__F8 miR-154-5p Affects the TGFB1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1 57154 7040 4087 4088 4089 4092 PMC8818415__F9 Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma 1537 5728 790 472 3621 PMC8818945__F10 Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells 596 581 2621 1728 PMC8825743__F3 Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review) 4055 1969 2475 847 PMC8826578__F3 Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases 998 100507127 83461 5218 PMC8827164__F5 Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosis 7450 3674 6129 6187 5579 5293 2353 4736 5336 3690 4067 6194 6132 6235 2162 6208 PMC8829035__F9 Trilobatin, a Natural Food Additive, Exerts Anti-Type 2 Diabetes Effect Mediated by Nrf2/ARE and IRS-1/GLUT2 Signaling Pathways 9817 1728 847 3630 8544 PMC8829728__F4 Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation 3929 929 7099 PMC8832142__F2 Interaction Between Intracellular Energy Metabolism and Signaling Pathways During Osteogenesis 8473 10724 860 1499 3939 2744 2475 PMC8834070__F4 Shifting the Focus of Signaling Abnormalities in Colon Cancer 1499 6925 4609 595 1021 1019 3725 2353 898 4088 1017 PMC8834284__F1 Characterization of Gfat1 (zeppelin) and Gfat2, Essential Paralogous Genes Which Encode the Enzymes That Catalyze the Rate-Limiting Step in the Hexosamine Biosynthetic Pathway in Drosophila melanogaster 5238 6675 8473 PMC8834563__F2 Enhanced Loss of Retinoic Acid Network Genes in Xenopus laevis Achieves a Tighter Signal Regulation 6713 1718 1595 5212 7108 1593 120227 50814 51478 10682 1591 1594 7421 1717 1628 PMC8835786__F3 SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19 4827 7187 29110 3661 PMC8835893__F5 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance 6469 50846 3549 6608 51684 9149 6722 PMC8836129__F4 R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1 545 472 56897 5888 PMC8836862__F10 Blood Bacteria-Free DNA in Septic Mice Enhances LPS-Induced Inflammation in Mice through Macrophage Response 7099 4615 7189 3661 54106 PMC8836911__F1 Theranostic Interpolation of Genomic Instability in Breast Cancer 5728 2885 2475 1019 983 1021 1017 545 472 672 675 5888 PMC8837817__F1 Cholinergic anti-inflammatory pathway 3717 6774 7099 3553 1139 PMC8840292__F6 Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus) 225 5825 7913 23457 8647 238 8528 4118 1118 26275 5185 57103 340485 5660 2592 64781 PMC8843878__F3 Chinese herbal decoction astragalus and angelica exerts its therapeutic effect on renal interstitial fibrosis through the inhibition of MAPK, PI3K-Akt and TNF signaling pathways 1956 6401 4609 196 2932 1950 31 43 7422 1576 2100 5468 5733 2353 5578 5447 5241 7157 5709 1509 5970 4314 9520 8066 367 5765 7124 PMC8844185__F3 Future Directions in Diagnosis, Prognosis and Disease Monitoring of Adrenocortical Carcinoma: Novel Non-Invasive Biomarkers 1589 1585 1586 3293 100187761 6715 PMC8848293__F2 Maintenance of protein homeostasis in glia extends lifespan in C. elegans 22926 7494 468 PMC8849533__F8 Working model of the role of CNTN1 in the regulation of MAVS-mediated signaling and influenza A virus replication 57506 29110 3661 29761 1272 PMC8850794__F1 PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles 8213 5728 4193 2308 2475 PMC8851844__F8 Cluster analysis of splenocyte microRNAs in the pig reveals key signal regulators of immunomodulation in the host during acute and chronic Toxoplasma gondii infection 868 1540 442901 5810 602 5971 407019 10379 6773 4863 6886 PMC8852695__F8 Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling 4838 145258 3665 PMC8853618__F14 SPOCK1 Promotes the Development of Hepatocellular Carcinoma 1956 1019 6695 6714 PMC8853744__F2 Senescence in chronic wounds and potential targeted therapies 1642 6648 3569 PMC8857305__F3 Mechanical regulation of bone remodeling 6714 8111 5745 6010 9780 6608 51684 59341 PMC8857305__F4 Mechanical regulation of bone remodeling 4041 4040 50964 2932 4485 9113 26524 10631 387 4920 650 4090 4086 4089 PMC8859251__F9 Biomarker Value of miR-221 and miR-222 as Potential Substrates in the Differential Diagnosis of Papillary Thyroid Cancer Based on Data Synthesis and Bioinformatics Approach 6476 6955 717 1610 7249 572 6714 100187907 2626 5214 PMC8866876__F4 Nrf2 Pathway in Liver Diseases 8878 2810 9817 1571 29887 1728 2947 PMC8870348__F3 Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy 1630 1723 7084 4693 1633 25939 PMC8870611__F2 Prognostic and Predictive Molecular Markers in Cholangiocarcinoma 2263 1950 1956 2475 3082 6774 9021 PMC8871586__F8 Gene Ontology Groups and Signaling Pathways Regulating the Process of Avian Satellite Cell Differentiation 7168 7169 7170 7171 1756 7111 4703 4604 4606 4607 81 88 89 1674 7431 7273 8557 8736 PMC8874408__F6 3, 3′- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFRY1086 Phosphorylation 2475 6714 1499 6777 1956 6774 6773 1950 2932 472 PMC8875122__F1 Fungal Colonization and Infections—Interactions with Other Human Diseases 6850 64170 3603 2475 7054 920 PMC8875399__F1 F ig . 1.“Find-me” signals and their respective receptors for apoptotic and necrotic cells 24145 19 6376 1524 4240 2919 3164 7057 53637 1901 1903 8698 9294 2357 PMC8875868__F7 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance 4693 55170 2539 2950 PMC8875876__F4 Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression 8564 8942 121278 7166 PMC8879487__F1 Utility of Genomic Testing for Hyperphenylalaninemia 6697 121278 56521 5053 5092 PMC8879721__F8 Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling 3717 6774 1000 595 1019 PMC8881125__F7 4-Octyl Itaconate Prevents Free Fatty Acid-Induced Lipid Metabolism Disorder through Activating Nrf2-AMPK Signaling Pathway in Hepatocytes 9817 355 8011 PMC8881509__F7 Extracellular circulating miRNAs as stress-related signature to search and rescue dogs 4609 472 545 64065 637 64326 PMC8882646__F1 Interaction of Mycobacteria With Host Cell Inflammasomes 7124 114548 4814 3146 79792 9447 PMC8883113__F6 Prognostic Value of the Developmental Gene FZD6 in Young Saudi Breast Cancer Patients: A Biomarkers Discovery and Cancer Inducers OncoScreen Approach 4040 4041 1499 324 595 PMC8889667__F1 Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia 7157 4609 595 6280 PMC8891514__F1 Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection 8678 7189 51295 9961 1660 4615 7099 7186 10454 29110 3661 7098 3665 7187 114548 58484 9447 3431 57506 3606 PMC8892088__F4 Metabolic regulation of ferroptosis in the tumor microenvironment 7097 3458 3466 6772 23657 6520 2879 PMC8894239__F3 mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment 7040 11201 6955 50943 7096 7097 2645 406985 940 5728 PMC8894377__F4 Radiotherapy alters expression of molecular targets in prostate cancer in a fractionation- and time-dependent manner 3932 7535 5970 7334 7335 84433 4615 114609 23118 257397 10454 1950 10010 8717 8772 2712 4803 7189 7039 5971 4049 PMC8895452__F8 RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues 2194 23678 619501 6774 4513 PMC8895466__F1 Cell-based immunotherapy of glioblastoma multiforme 7852 1435 1436 PMC8897435__F8 Model of this study 221718 115908 595 PMC8898369__F8 TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer 1956 4312 960 6352 PMC8898834__F2 Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection 57506 5132 2475 PMC8899123__F3 Molecular Docking as a Therapeutic Approach for Targeting Cancer Stem Cell Metabolic Processes 6500 6502 2475 5019 51684 6469 6608 PMC8899174__F7 STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/B‐catenin pathway via binding to Annexin A2 in osteoporosis 83930 1499 302 324 860 249 248 PMC8901678__F1 Hepatic glucose, lipids, and amino acid metabolism 7038 4199 4118 2475 3417 PMC8901678__F3 Iron metabolism in the liver 55240 7018 84315 8031 2512 51312 4089 2056 151176 3569 6774 148738 3077 7036 154214 654 659 92 4092 164656 26234 23516 PMC8905633__F7 Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation 1956 351 6774 5290 5595 5594 3725 6714 5350 7124 PMC8908152__F6 Expression profiles of tRNA-derived fragments and their potential roles in lung adenocarcinoma 7124 355 8717 1616 23118 1610 4351 6955 4703 4149 1537 PMC8909190__F2 Transcriptomics Reveals Discordant Lipid Metabolism Effects between In Vitro Models Exposed to Elafibranor and Liver Samples of NAFLD Patients after Bariatric Surgery 445347 351 3416 6651 51083 5550 PMC8909324__F12 Biglycan Interacts with Type I Insulin-like Receptor (IGF-IR) Signaling Pathway to Regulate Osteosarcoma Cell Growth and Response to Chemotherapy 7341 1431 5728 PMC8909472__F2 Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance 2885 3845 3265 1021 1019 2475 PMC8909674__F4 Mitochondrial Stress Response in Cancer Progression 9140 9474 8408 9706 10533 64422 9776 60673 65018 664 139341 4976 PMC8910364__F9 Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway 4513 4312 4314 PMC8914027__F3 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway 3630 283131 57506 6421 7187 29110 101927851 1283 9081 7706 PMC8914027__F5 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway 2944 3661 10133 29110 57506 7187 10616 27068 6240 378938 6241 PMC8918735__F3 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia 9365 6651 6401 PMC8918735__F4 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia 246751 65057 6651 828 3242 472 7290 5447 351 7054 PMC8918735__F7 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia 2669 572 355 PMC8918735__F8 Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia 2669 572 355 PMC8918930__F10 Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer’s Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway 7054 5966 9575 PMC8922271__F5 Organelle interfaces by ER‐resident E3s 6400 10613 11160 81790 7327 51465 9958 23052 79188 11018 55161 54472 2060 8887 6048 3638 PMC8922318__F5 Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia 355 929 7124 7189 7186 1616 23118 51295 5624 5062 5058 51701 2002 4149 4208 994 6722 2353 PMC8922318__F6 Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia 858 859 613 5266 3270 5350 10345 90550 3371 PMC8922473__F6 Retinoic Acid-Induced 2 (RAI2) Is a Novel Antagonist of Wnt/Beta-Catenin Signaling Pathway and Potential Biomarker of Chemosensitivity in Colorectal Cancer 999 1499 1488 2932 4040 4041 324 10742 PMC8924081__F4 G-protein coupled receptor 34 regulates the proliferation and growth of LS174T cells through differential expression of PI3K subunits and PTEN 6714 2857 5163 5728 PMC8924093__F3 Anti-HER2 therapy in metastatic breast cancer: many choices and future directions 1956 3479 2475 1021 1019 5728 595 PMC8924168__F5 BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling 672 2475 10397 5209 3991 8915 5565 580 2194 2064 8660 7145 57521 2997 572 6464 602 6199 8241 9169 25957 51322 6432 5339 6431 51593 8260 22985 8602 6175 54888 55660 9967 6218 6181 6672 5371 51564 6942 121536 9898 1616 80012 546 9425 55677 1106 11284 9656 51755 8315 219771 6749 4175 571 5883 PMC8927572__F3 Proposed precision treatment strategies for MAPK pathway-mutated head and neck cancer 3265 1956 5594 673 2065 PMC8928136__F2 Signaling pathways by DJ-1: An updated overview 90427 2002 6647 1644 PMC8928136__F3 Signaling pathways by DJ-1: An updated overview 51024 5728 6048 PMC8928136__F4 Signaling pathways by DJ-1: An updated overview 1616 7186 7189 PMC8929637__F2 An illustration of the known proteins involved in glycerolipid synthesis in Apicomplexa parasites 4018 6924 6923 355 6921 PMC8931408__F2 Innate Immune Evasion by Human Respiratory Syncytial Virus 64127 57506 57762 29110 7187 3661 7189 7706 114548 6773 10379 7098 51284 4615 9636 6772 8638 3454 9021 PMC8931468__F6 Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/Beta-Catenin Pathway 999 2932 324 1499 PMC8932105__F7 Tumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway 6774 6657 79923 PMC8932121__F2 Inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD 23118 4615 7189 3550 140609 114548 PMC8939237__F1 Regulatory Pathways Governing Metabolic Control of Puberty Discerned from Rodent, Nonhuman Primate, and Human Studies 23237 2475 23411 8726 6462 PMC8941124__F7 Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells 55332 581 472 648 993 55690 596 4609 8408 PMC8943949__F7 Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells 999 1000 4318 4313 1998 836 595 1019 PMC8944072__F3 Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease 6418 260431 4599 7216 1956 998 55742 PMC8944968__F3 Circular RNA ITCH: An Emerging Multifunctional Regulator 2932 1499 324 83737 PMC8945343__F5 Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies 10628 5225 594857 PMC8945564__F6 Quantitative Metabolomics of Tissue, Perfusate, and Bile from Rat Livers Subjected to Normothermic Machine Perfusion 5091 100188776 2548 PMC8945726__F2 Mitochondrial Oxidative Stress and Cell Death in Podocytopathies 581 596 841 842 PMC8946789__F8 The Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal Offspring 6662 860 4312 7076 PMC8948217__F3 Notch signaling pathway: architecture, disease, and therapeutics 6928 6662 6927 PMC8949885__F2 Marginal Zone B-Cell Populations and Their Regulatory Potential in the Context of HIV and Other Chronic Inflammatory Conditions 613 84890 958 9308 3164 4929 8013 81793 2475 PMC8953107__F5 Fucoidan (Undaria pinnatifida)/Polydopamine Composite-Modified Surface Promotes Osteogenic Potential of Periodontal Ligament Stem Cells 27040 23440 572 790 25777 PMC8953253__F4 Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator 3977 6774 3716 5008 2885 50964 9180 3717 51384 PMC8955100__F1 Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV/SIV Infection 962 3902 5817 201633 7535 920 3932 940 11126 151888 PMC8956597__F3 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer 817 818 572 1956 207 10000 2475 6198 6199 2549 2932 1026 595 6464 2885 673 369 5605 4609 5594 4690 5058 56924 3725 8440 5062 10298 25 1399 27 6714 5747 PMC8956597__F4 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer 817 818 572 1956 207 10000 2475 6199 6198 2549 2932 1026 595 6464 2885 6654 673 369 5605 5594 4609 4690 5058 56924 8440 3725 5062 10298 1399 25 27 6714 5747 6777 PMC8956597__F5 Temporal dynamics from phosphoproteomics using endoscopic biopsy specimens provides new therapeutic targets in stage IV gastric cancer 817 818 572 207 1956 6198 2475 10000 6199 2549 1026 595 6464 2885 6654 369 673 5605 5594 4609 4690 5058 56924 8440 3725 5062 10298 1399 25 27 6714 5747 PMC8957965__F8 Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control 1571 7019 65018 PMC8957988__F2 An Update of Long-Noncoding RNAs in Acute Kidney Injury 283131 378938 5820 387066 643911 55384 5728 60674 255082 PMC8958887__F7 M6A writers regulated by the IL-6/STAT3 inflammatory pathway facilitate cancer cell stemness in cholangiocarcinoma 56339 57721 9589 10644 1499 3569 55553 6774 PMC8960923__F2 Estrogen Receptor Complex to Trigger or Delay Estrogen-Induced Apoptosis in Long-Term Estrogen Deprived Breast Cancer 83939 468 6774 7124 PMC8962202__F3 CIGB-300-Regulated Proteome Reveals Common and Tailored Response Patterns of AML Cells to CK2 Inhibition 84126 79705 3984 2783 4086 8554 896 55011 1432 5934 122704 92259 963 28977 81619 10393 9725 51021 23327 PMC8964062__F1 T Cell Metabolism in Infection 940 7249 6009 942 941 3099 4609 2308 PMC8964949__F6 Metalloprotease-Disintegrin ADAM8 Alters the Tumor Suppressor miR-181a-5p Expression Profile in Glioblastoma Thereby Contributing to Its Aggressiveness 1950 6774 101 6696 4318 PMC8965480__F9 Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinas 1436 968 558 54209 PMC8965725__SF1 Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy 594857 3661 115004 PMC8965836__F9 Parathyroid Hormone Promotes Human Umbilical Vein Endothelial Cell Migration and Proliferation Through Orai1-Mediated Calcium Signaling 5741 6786 4772 84876 1277 PMC8966512__F1 Intestinal Wnt in the transition from physiology to oncology 22943 4041 4040 607 324 PMC8966751__F4 Expression and Regulation Network of HDAC3 in Acute Myeloid Leukemia and the Implication for Targeted Therapy Based on Multidataset Data Mining 1267 759 7225 2638 387 351 6722 2626 5066 6714 100187907 7851 PMC8968680__F3 Anticancer Activity of Erianin: Cancer-Specific Target Prediction Based on Network Pharmacology 2322 2064 2885 2113 1019 595 PMC8968959__F1 Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration 1950 867 2885 PMC8969013__F1 STING1 in Different Organelles: Location Dictates Function 340061 29110 3661 115004 57506 PMC8969576__F3 Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis 6347 1118 1116 3586 960 PMC8970588__F8 Simplified model showing how availability of the dedicated chaperone Rrb1 or Acl4 and the here uncovered regulatory network cooperate to balance Rpl3 and Rpl4 expression by co-translationally regulating RPL3 and RPL4 mRNA levels 6122 6124 10043 23632 PMC8973075__F3 Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome 7035 9242 7018 2271 718 727 4179 1604 966 PMC8975241__F2 Metabolic effects of PD-1 ablation or blockade in effector (Teff) and regulatory (Treg) T cells 2475 6714 4772 PMC8976637__F2 Disease: Recessive ADAMTSL4 Mutations and Craniosynostosis with Ectopia Lentis 2200 1431 6497 PMC8981655__F3 m6A binding protein YTHDF2 in cancer 51441 7124 2932 79817 4609 7422 5728 2475 11098 8835 90427 3097 1499 8312 7157 5187 51035 60674 64077 4824 80854 9314 PMC8981655__F4 m6A binding protein YTHDF2 in cancer 51441 7852 6663 1956 2303 7503 5820 27161 PMC8983055__F3 Proteomic and Phosphoproteomic Changes of MAPK-Related Inflammatory Response in an Animal Model of Neuropathic Pain by Differential Target Multiplexed SCS and Low-Rate SCS 1270 1271 2 197 150209 9131 1116 3609 7431 3084 3929 3075 1431 7099 718 3146 3148 1401 5004 6774 348 6653 PMC8989557__F2 Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy 3716 3717 1493 940 325 6773 6772 6774 PMC8992454__F1 Barriers to achieving a cure in lymphoma 973 613 930 920 3932 7535 6850 940 5580 4067 6503 8525 5728 407975 118788 3707 695 5335 596 598 4170 5293 5290 7409 2885 6654 9825 5579 7187 7186 3635 5170 84433 7189 8915 10892 80149 207 208 10318 7128 7514 3551 2475 7097 4615 4792 4794 3725 2353 84807 PMC8993567__F4 Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical Prospect 972 961 310 56949 8546 64321 1958 23365 952 940 7249 6009 10628 3553 11126 942 2475 6098 939 951 962 1043 974 967 PMC8994689__F3 Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases 4025 50507 6120 PMC8995529__F5 Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway 595 1026 1027 329 331 5925 1021 1019 1029 7157 1017 5111 1537 2475 330 836 PMC8996410__F3 Proteolysis-targeting chimeras (PROTACs) in cancer therapy 6046 23476 8019 29117 65980 1021 1019 1956 1017 7465 PMC8998017__F1 STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments 115004 5167 3569 PMC8998186__F4 Recycling and Reshaping—E3 Ligases and DUBs in the Initiation of T Cell Receptor-Mediated Signaling and Response 8239 57162 219333 8915 10892 83737 7189 3726 9958 4193 PMC8998228__F1 Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family 572 90427 638 8739 581 666 PMC8998982__F1 Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response 4609 8318 4172 4174 4173 4176 4175 4171 5426 81620 990 1017 5111 7486 894 1021 1019 PMC8999457__F2 Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System 54941 57506 29110 3661 3665 3659 7098 10379 PMC8999618__F2 Sequence Requirements for miR-424-5p Regulating and Function in Cancers 7503 22863 545 472 672 285987 7465 7157 4609 1017 4661 1019 5820 619501 100506826 100048912 7422 PMC8999618__F3 Sequence Requirements for miR-424-5p Regulating and Function in Cancers 1499 324 139285 4089 9493 9055 4088 317 836 595 2182 125170 4118 596 2475 7351 23410 6774 PMC9002053__F3 Translational Control of COVID-19 and Its Therapeutic Implication 1998 2001 1983 1999 6729 1997 1975 54464 57506 3661 29110 6772 6773 10379 PMC9005190__F3 Receptor-specific signaling signatures 5447 355 2592 4018 PMC9005294__F3 Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway 5164 5728 572 4318 4313 5266 4193 PMC9005906__F1 Immunomodulation as a Protective Strategy in Chronic Otitis Media 64127 55054 114548 55655 147945 3659 4615 10392 1611 7124 1956 PMC9006445__F2 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies 60673 8408 9776 22863 55626 PMC9006445__F4 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies 55384 114548 8772 1956 6714 8717 79792 6774 581 2539 857 1687 5588 1236 PMC9007670__F2 Pathophysiological Mechanisms Underlying Multiple Organ Dysfunction in Cytokine Release Syndrome 3466 7186 8772 8717 79792 114548 PMC9009237__F6 “Reframing” dopamine signaling at the intersection of glial networks in the aged Parkinsonian brain as innate Nrf2/Wnt driver: Therapeutical implications 4041 4040 324 1499 2932 1813 PMC9010204__F3 Targeting Oxidative Stress and Endothelial Dysfunction Using Tanshinone IIA for the Treatment of Tissue Inflammation and Fibrosis 4089 4087 4088 27035 50507 7099 6774 2475 PMC9012636__F14 Study on the Mechanism of Üstikuddus Sherbiti in Ischemic Cerebrovascular Diseases: Based on Network Pharmacology 5728 4099 11201 3371 1277 2717 PMC9013863__F2 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma 4609 6654 2885 693147 693164 100616486 1956 5163 5728 PMC9013863__F3 Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma 7248 27250 724022 253260 102466516 6657 PMC9013884__F7 Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases 355 6774 2166 4803 1956 2695 4313 4318 7054 3459 3460 PMC9016203__F5 Therapeutic Applications of Physalins: Powerful Natural Weapons 4040 4041 1499 324 2932 6774 331 51684 2735 6608 PMC9017576__F1 TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook 7124 10628 114548 920 923 PMC9019160__F1 Targeting the PI3K/AKT/mTOR pathway in epithelial ovarian cancer, therapeutic treatment options for platinum-resistant ovarian cancer 842 572 6009 7249 7248 4193 5728 2932 5164 545 472 5163 PMC9020229__F1 Endocrine Regulation on Bone by Thyroid 3480 3479 860 8532 54361 1499 3549 652 4090 4086 4089 PMC9023560__F7 HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis 2475 3082 1000 4803 999 PMC9023794__F2 Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection 8717 717 7186 7188 8737 11035 8772 197259 81030 PMC9023807__F1 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer 1499 407009 999 1000 PMC9023807__F3 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer 5894 5290 2932 5728 PMC9025012__F2 Implications of Sphingolipid Metabolites in Kidney Diseases 6611 64781 27293 2531 1674 8879 PMC9025114__F3 Selectin-Mediated Signaling—Shedding Light on the Regulation of Integrin Activity in Neutrophils 6714 6850 695 5336 5879 8935 3383 PMC9025760__F2 Characterization and Roles of Membrane Lipids in Fatty Liver Disease 9927 10400 5091 PMC9026333__F6 Heparan Sulfate, Mucopolysaccharidosis IIIB and Sulfur Metabolism Disorders 4397 875 2937 867 1491 51380 4357 7263 PMC9026965__F2 Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health 664 55669 7421 PMC9027058__F2 KRAS: A Druggable Target in Colon Cancer Patients 2885 1950 1956 5163 2475 PMC9028246__F1 Genomic Hippo Pathway Alterations and Persistent YAP/TAZ Activation: New Hallmarks in Head and Neck Cancer 4485 60485 9113 55233 PMC9030470__F3 Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis 9055 23429 5931 5928 10873 PMC9030544__F4 Proteomic Analysis of Endometrial Cancer Tissues from Patients with Type 2 Diabetes Mellitus 406937 406936 406935 87 6712 PMC9030597__F1 Pathway-Based Genetic Score for Oxidative Stress: An Indicator of Host Vulnerability to Phthalate-Associated Adverse Neurodevelopment 847 4790 6667 2876 50507 6647 6648 4784 1543 2353 PMC9031059__F3 Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity 4360 5955 26088 9969 4665 PMC9031068__F2 Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action 6714 5894 1499 2932 PMC9031703__F5 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response 3667 5163 2932 7249 7248 6009 2475 5728 PMC9031790__F3 Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents 572 581 83939 PMC9032523__F1 COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3? 8564 8942 130013 23475 93100 952 203447 316 10135 4837 PMC9032523__F3 COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3? 64802 349565 23057 10135 952 4837 316 635 PMC9032805__F3 Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression 1356 6563 344022 4133 5604 91147 4929 57111 537 1337 9296 4697 PMC9035407__F10 RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein 5741 9368 10636 6446 8074 PMC9036297__F4 Uncovering Novel Pre-Treatment Molecular Biomarkers for Anti-TNF Therapeutic Response in Patients with Crohn’s Disease 1398 572 29984 PMC9037381__F3 Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells 999 1499 3552 4179 4318 4322 338322 79671 114548 3146 101 PMC9038780__F10 Putative synergistic effects of MGO and aSyn in the midbrain 815 816 55364 PMC9039621__F1 Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis 2219 7054 727 721 1431 729 PMC9048451__F2 Abnormal synaptic plasticity and impaired cognition in schizophrenia 7054 1644 3360 2744 PMC9051099__F8 MyD88 signaling in HSCs in fibrosis model 4615 3627 2833 3717 3716 6772 4843 7124 PMC9055718__F6 Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells 3553 4049 3661 PMC9058298__F6 Heterogeneous nuclear ribonucleoprotein K promotes the progression of lung cancer by inhibiting the p53‐dependent signaling pathway 3190 545 472 595 PMC9060002__F7 Data suggest multiple potentially active epithelial–mesenchymal transition-associated pathways in CF, with YAP1 mediating their crosstalk 1080 3326 51176 3939 6279 4609 7157 2934 857 PMC9062100__F2 Toll-Like Receptors and Th Responses in Viral Myocarditis 81793 3553 51284 7100 7098 4615 4118 3665 7099 7097 6774 7096 3606 10333 PMC9066069__F3 High‐fat diet (HFD)‐induced reprogramming of the hepatic clock and metabolic homeostasis 406 9575 4280 10135 23411 PMC9066134__F1 Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients 324 59272 920 PMC9069407__F3 Generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation 3458 54918 146223 8405 9026 7431 3838 6774 3837 56169 10735 10274 PMC9075737__F2 Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension? 3934 1958 4318 4313 5111 1616 5728 6667 PMC9077270__F8 Alpha-synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae 55737 51699 8724 8039 PMC9077970__F4 Dual role of autophagy in acute myeloid leukemia 2475 2194 7942 PMC9080378__F7 Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen 596 2263 6662 PMC9082817__F7 Transcriptomic Profiles of Splenic CD19+ B Cells in Mice Chronically Infected With the Larval Echinococcus granulosus 10631 1000 1277 1292 10581 4323 1278 929 56675 967 947 79689 857 4179 8519 7049 1604 239 4240 5168 3685 3554 2760 3075 2153 6504 56895 6817 3977 3674 1545 5156 2878 79168 5196 4783 2335 9180 27250 6772 1291 3500 4352 4351 928 PMC9082937__F7 Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis 7099 558 9021 PMC9083497__F5 Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells 999 79923 1869 8289 4851 6774 55193 196528 29117 PMC9084610__F1 COVID-19 Infection During Pregnancy Induces Differential Gene Expression in Human Cord Blood Cells From Term Neonates 4703 200186 2308 102 PMC9086029__F6 Microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma 10352 10521 10042 25825 27341 11179 10741 23549 10941 10318 7454 256815 1549 10100 10231 150921 23048 10257 4115 10794 140885 4189 100271715 10221 10384 10628 100526767 144983 25827 100820829 10184 1073 10103 146330 162963 3178 191 153642 10444 196074 202915 158234 25980 11273 57119 1277 10138 100507421 10075 10541 134353 10575 10472 10206 284434 11185 10838 10666 100132406 2683 200205 10270 353088 10226 23241 115761 132299 1006 1129 10343 143570 140890 10936 118738 10640 100462977 10478 1432 118429 122786 10493 4329 134147 10079 137492 10659 124491 1408 83475 112399 100131390 PMC9086029__F7 Microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma 100289678 7484 1856 1387 2817 2475 1000 10055 4916 4801 7482 10075 10109 10067 100463486 100462981 27113 4143 5732 6667 3569 57621 10084 10090 4615 2305 100129543 100526842 28964 30061 PMC9088184__F6 PGK1-coupled HSP90 stabilizes GSK3B expression to regulate the stemness of breast cancer stem cells 1499 2932 5230 PMC9088190__F1 Methods for monitoring cancer cell pyroptosis 7454 3146 79792 114548 7124 1687 56169 3002 55876 PMC9095362__F1 Cancer Stem Cell-Derived Exosomes in Cancer Progression 81 1606 8434 27250 5728 11191 PMC9097215__F2 Tumor Suppressor Kinase LKB1: Metabolic Nexus 3091 3099 2023 5132 PMC9097822__F1 Signalling dynamics, cell decisions, and homeostatic control in health and disease 7039 255324 374 1950 685 1839 2069 3084 9542 10718 145957 2353 595 PMC9099149__F1 Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork/Schlemm’s Canal 6714 387 7204 5879 7074 PMC9099196__F4 Gut homeostasis, injury, and healing: New therapeutic targets 387 5879 2885 PMC9099524__F1 Hypoxia as a Modulator of Inflammation and Immune Response in Cancer 7428 2056 4313 PMC9100777__F1 Bilayer Forming Phospholipids as Targets for Cancer Therapy 907 5091 9791 10400 100379198 5833 81490 85465 23761 PMC9101307__F3 New Player in Depression: MiRNAs as Modulators of Altered Synaptic Plasticity 51176 81029 7472 1499 627 23411 PMC9102653__F2 Subversion of the immune response of human pathogenic spirochetes 1356 716 715 721 720 10747 727 PMC9103623__F1 Prolonged Mechanical Ventilation: Outcomes and Management 7099 2308 2475 PMC9104610__F6 Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling 7424 7040 10203 7422 7075 284 285 PMC9107211__F3 Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study 933 971 613 975 930 4067 695 6850 29760 2885 25780 8915 10892 2932 2638 PMC9107479__F1 Extrinsic and intrinsic apoptosis pathways, indicating pharmacological agents and their therapeutic targets 637 331 581 8772 3458 PMC9110208__F9 Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway 9817 2475 2539 4772 7189 4318 1513 PMC9110257__F9 LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells 1869 23395 9927 836 PMC9111174__F8 Transcriptome Analyses of Chicken Primary Macrophages Infected With Attenuated Salmonella Typhimurium Mutants 10392 3606 7096 4615 3569 7098 51284 3661 10642 3665 3553 3586 PMC9111413__F2 Non‐steroidal anti‐inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID‐19 64806 8213 3568 90865 85480 PMC9117997__F1 Metabolism and subcellular enrichment of phosphoinositides 200576 9896 3631 8821 4952 5728 PMC9119001__F3 Metabolic engineering of microorganisms for L-alanine production 7808 210 64853 PMC9120845__F2 Aberrations in the Cross-Talks Among Redox, Nuclear FactorKB, and Wnt/Beta-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome 412 8942 8564 51166 5447 59330 3043 4025 340024 1991 8288 3122 4069 5308 607 PMC9121315__F9 Hepatic pannexin‐1 mediates ST2+ regulatory T cells promoting resolution of inflammation in lipopolysaccharide‐induced endotoxemia 6761 90865 24145 114548 7099 PMC9122672__F1 Bile Acids and Nuclear Receptors in Acupuncture in Improving Crohn's Disease 1581 1582 80270 9420 1593 8213 PMC9124632__F1 Type-I interferons in the immunopathogenesis and treatment of Coronavirus disease 2019 115004 64127 57506 3716 29110 3661 3665 7099 7187 3466 7297 4615 7098 51284 51311 54106 7189 PMC9126300__F2 Deciphering the Link Between ERUPR Signaling and MicroRNA in Pathogenesis of Alzheimer’s Disease 22926 468 83939 7494 7186 PMC9126665__F10 Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NFKB Signaling Pathway 9817 2730 2944 5052 266 7124 7099 4615 PMC9127077__F1 C-Type Lectin Receptor Signaling in the Intestinal Microbiota-Inflammation-Cancer Axis 5894 6850 1499 79595 2920 64170 10892 196 6774 PMC9127082__F1 Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells 8031 246 2879 23657 1723 PMC9128303__F1 IGF-I structure and activity 2885 2475 6194 5728 7248 PMC9131029__F2 Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis 55711 84188 8443 8540 2819 387521 10400 PMC9133560__F4 Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles 1499 4040 4041 324 1896 4090 4086 6469 PMC9136161__F2 Degradative and Non-Degradative Roles of Autophagy Proteins in Metabolism and Metabolic Diseases 8678 9554 9342 8773 6810 6809 PMC9136572__F3 Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases 7097 7099 8213 114548 9294 948 1687 4975 PMC9139752__F1 Can Schlafen 11 Help to Stratify Ovarian Cancer Patients Treated with DNA-Damaging Agents? 545 91607 2146 PMC9139855__F2 Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications 405 196 1544 1543 100187761 367 5327 3569 2006 PMC9139943__F4 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance 672 1874 5888 PMC9142129__F6 Inference of Molecular Regulatory Systems Using Statistical Path-Consistency Algorithm 10454 4149 3727 2885 6722 1616 5062 5058 2645 929 5894 355 4763 7189 51295 7186 PMC9143160__F1 PD-1/PD-L1, MDSC Pathways, and Checkpoint Inhibitor Therapy in Ph(-) Myeloproliferative Neoplasm: A Review 3717 3466 3845 1950 5728 PMC9143262__F2 Platelet-Derived Growth Factor Pathway in Pulmonary Arterial Hypertension: Still an Interesting Target? 5155 56034 80310 PMC9145061__F1 Functional Properties of Cancer Epithelium and Stroma-Derived Exosomes in Head and Neck Squamous Cell Carcinoma 54918 4089 27250 4087 4088 2002 11140 100302142 5728 1956 80705 PMC9145654__F5 TGFBeta-Treated Placenta-Derived Mesenchymal Stem Cells Selectively Promote Anti-Adipogenesis in Thyroid-Associated Ophthalmopathy 3156 4087 4089 4088 PMC9146014__F1 Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses 790 1723 7372 7371 978 51727 PMC9146250__F3 New Insights into Hematopoietic Stem Cell Expansion to Stimulate Repopulation of the Adult Blood System for Transplantation 4151 7862 6714 4067 947 2475 196 7066 PMC9147390__F9 Evaluation of TILI-2 as an Anti-Tyrosinase, Anti-Oxidative Agent and Its Role in Preventing Melanogenesis Using a Proteomics Approach 5595 7306 5900 5294 23118 5293 5077 6885 842 5894 10454 7042 54623 5291 4092 4090 6300 7043 5290 23456 654 57154 64750 92 PMC9148418__F6 Pharmacological modulation of healthy aging with urolithin A, NAD+, resveratrol and spermidine 23410 23411 4899 PMC9148969__F8 Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response 3480 54106 3479 596 1956 572 581 55054 PMC9155226__F1 Trimming the fat: is there a health economic case for the use of new lipid-lowering drugs in chronic kidney disease? A scoping review 4018 3949 3931 9619 4023 PMC9155920__F2 Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling 9817 4615 1728 114548 PMC9157408__F2 Is there a role for HSF1 in viral infections? 3297 10533 2475 PMC9160246__F3 Neuroinflammation in PD 6376 3569 7124 3553 3383 PMC9160246__F9 Mechanistic view of roles of different K+-channels in the diagnosis and treatment of the PD pathogenesis 2668 5447 3725 PMC9162042__F3 Multifaceted regulation and functions of 53BP1 in NHEJ-mediated DSB repair (Review) 545 9656 3014 55183 472 6667 4001 51514 8451 7518 3981 221937 672 9097 PMC9162043__F7 Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via the glycolysis-dependent AKT/mTOR signaling 10399 5452 3480 2475 3099 3939 PMC9163834__F7 MicroRNA Expression in Circulating Leukocytes and Bioinformatic Analysis of Patients With Moyamoya Disease 9350 147111 50964 6259 27130 324 8454 5465 PMC9163835__F1 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway 5728 114548 2475 2729 1728 PMC9163835__F2 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway 6774 7249 7248 2475 3146 7099 7942 PMC9163835__F3 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway 5728 6009 89780 596 581 PMC9163835__F4 Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway 3717 596 3146 7099 7942 581 PMC9165365__F3 “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders 90550 355 637 PMC9166238__F1 Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease 7942 2475 23411 65018 1509 PMC9169033__F4 Metabolic adaptations in MS 4397 2744 920 355 PMC9169372__F7 Targeting type IG phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer 4361 672 10111 PMC9170579__F6 Long noncoding RNAs (lncRNAs) in human lymphomas 100124700 60674 2078 8726 2146 23512 PMC9170611__F4 Decrypting a path based approach for identifying the interplay between PI3K and GSK3 signaling cascade from the perspective of cancer 5728 7249 7248 5163 253260 1499 4040 4041 PMC9170953__F4 Diverse Roles of NETosis in the Pathogenesis of Lupus 54106 3146 51284 PMC9170969__F3 Antiviral immune response by African swine fever virus (ASFV) 22926 468 83939 596 8717 7186 1540 637 581 PMC9171972__F2 YAP1 in liver cancer stem cells: proven and potential mechanisms 4485 9113 10413 100187761 4041 1499 4088 79923 3481 3480 3482 PMC9174462__F1 Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target 3553 114548 1687 9447 581 79792 55876 PMC9178120__F4 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors 5817 8480 27165 6510 81539 PMC9179423__F3 Bottom-Up Approach to the Discovery of Clinically Relevant Biomarker Genes: The Case of Colorectal Cancer 4434 387569 836 2885 8213 572 324 4089 581 4436 51426 PMC9179506__F1 Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors 672 5728 5163 PMC9181319__F1 Roles of RANK/RANKL/OPG in Cardiac, Skeletal, and Smooth Muscles in Health and Disease 860 7189 7186 7188 4772 PMC9181382__F4 Rethinking Sesquiterpenoids: A Widespread Hormone in Animals 3156 4598 10654 PMC9181656__F2 Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance 6774 182 4851 6347 1003 729230 PMC9182402__F5 Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin 2305 22943 3337 1649 3725 467 389692 11004 694 9709 3925 5347 147841 627 1063 23397 3835 79682 701 1958 203068 54821 9212 11130 2491 57405 63967 11065 1870 5424 4616 10912 6402 5427 PMC9184651__F4 Signaling pathways of chronic kidney diseases, implications for therapeutics 50507 4087 4088 7852 1499 PMC9185718__F5 An effective nano drug delivery and combination therapy for the treatment of Tuberculosis 8772 4615 836 3654 3623 95 PMC9187083__F9 Understanding pathogen–host interplay by expression profiles of lncRNA and mRNA in the liver of Echinococcus multilocularis-infected mice 114609 4615 3596 3627 1959 1960 6772 6774 4087 4088 50943 PMC9187756__F1 Four ferroptosis defense pathways 2879 23657 6520 1719 1723 4975 PMC9191761__F1 Non-canonical WNT signalling pathways 5879 387 4919 4920 6259 PMC9198382__F4 Advances in the systemic treatment of therapeutic approaches in biliary tract cancer 2549 673 2885 238 PMC9199004__F4 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways 7050 8562 2332 801 3720 81034 865 4089 119504 8879 5728 3988 1871 1054 5284 840 3099 7048 8743 836 10410 5609 3659 6342 23405 3458 3627 4296 3479 3586 3574 6352 3662 3552 949 4615 PMC9199004__F5 Major Downregulation of Circulating microRNAs in Zika Acutely Infected Patients: Potential Implications in Innate and Adaptive Immune Response Signaling Pathways 1490 4322 4312 2002 4760 865 2034 10018 3725 5595 6772 860 488 1116 7431 8795 5524 8678 4314 5328 604 5728 6774 92140 5008 4133 5604 5894 3716 3717 6464 2885 9180 7189 54106 3456 51655 7099 3572 7297 3654 PMC9201920__F3 Non-Coding RNAs as Novel Regulators of Neuroinflammation in Alzheimer’s Disease 4615 54209 3553 PMC9203688__F1 Ferroptosis and Autoimmune Diseases 3569 2879 3146 PMC9203694__F6 Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies 22880 47 355 PMC9204003__F2 Long Noncoding RNA and Circular RNA: Two Rising Stars in Regulating Epithelial-Mesenchymal Transition of Pancreatic Cancer 367 55000 79659 100287559 728655 647979 347689 23642 85028 283120 729082 100233209 79104 60674 7503 5820 693207 4907 100316868 1956 6772 2260 9655 9021 114548 3209 387 7048 7046 6657 55384 2297 2146 6935 378938 100124700 101805492 474338 PMC9204952__F9 Genome-wide association mapping and genomic prediction for pre‑harvest sprouting resistance, low Alpha-amylase and seed color in Iranian bread wheat 51411 7018 1879 64641 PMC9205109__F8 Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury 10628 114548 79792 PMC9205143__F2 Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders 1000 999 541471 6659 4916 PMC9207346__F4 Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence 1019 472 4361 10111 406 545 PMC9214699__F5 Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma 32 31 5106 2203 3397 5105 51422 5571 5564 9021 10891 6720 5293 5834 1978 808 5562 2308 5501 6009 207 8835 5576 5573 5256 5295 5499 100306940 5595 3265 6194 801 5500 5296 5601 5590 1399 805 5604 10580 5584 PMC9218363__AF1 Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A 1977 2475 8772 PMC9221142__F2 Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance? 1956 6714 367 3064 1499 PMC9227908__F1 Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches 3939 4609 57103 2539 3845 22934 PMC9228804__F3 Tumor Suppressive Effects of GAS5 in Cancer Cells 60674 5728 2475 595 1017 1977 PMC9229135__F2 Clinical Escherichia coli: From Biofilm Formation to New Antibiofilm Strategies 55137 2313 3535 4397 PMC9229972__F3 Network Approaches to Integrate Analyses of Genetics and Metabolomics Data with Applications to Fetal Programming Studies 2638 718 717 220963 84680 1431 PMC9230919__F1 Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer’s Disease with a Change in Metabolic Profile 1719 4548 4524 4522 1103 PMC9231053__F5a Estimation of Carbon Metabolism in Saccharomyces cerevisiae Acclimatized to Glycerol Assimilation with Quantitative PCR 10763 100187761 2875 PMC9231053__F6a Estimation of Carbon Metabolism in Saccharomyces cerevisiae Acclimatized to Glycerol Assimilation with Quantitative PCR 130589 666 7504 PMC9233299__F7 Beta-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes 6390 23408 717 PMC9234279__F6 Methyl Gallate Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via the AMPK/NFKB Signaling Pathway in vitro and in vivo 7077 4313 4318 999 PMC9234462__F1 Structure Basis of Phytochemicals as Metabolic Signals for Combating Obesity 7099 1690 29110 PMC9236130__F2 Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer 1902 2475 4018 9170 7205 3091 6714 23566 10161 6774 619501 3082 PMC9238352__F6 CASP-Model Sepsis Triggers Systemic Innate Immune Responses Revealed by the Systems-Level Signaling Pathways 100187761 8258 572 5066 59330 PMC9240190__F3 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy 5465 948 23410 8408 7249 7248 6009 PMC9240190__F4 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy 114548 7099 4615 7189 9817 4094 PMC9240190__F5 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy 102 4092 4089 4087 4088 6010 PMC9240190__F6 Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy 55013 90550 6262 PMC9240244__F7 Working model of the protective effects of Rb1 against D-GalN/LPS induced ALI: Rb1 inhibition of the TLR4/MyD88/NFKB signaling pathway and NLRP3 inflammasome activation 4615 5925 114548 PMC9240796__AF1 Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway 3091 5163 664 PMC9243238__F2 Endoplasmic Reticulum Stress and Pathogenesis of Vascular Calcification 7494 83939 468 22926 860 PMC9247467__F3 CD44 In Sarcomas: A Comprehensive Review and Future Perspectives 4323 102 6868 6657 79923 4318 7291 960 PMC9247874__F3 Long Non-coding RNAs With In Vitro and In Vivo Efficacy in Preclinical Models of Esophageal Squamous Cell Carcinoma Which Act by a Non-microRNA Sponging Mechanism 100507056 6839 81848 7038 108570035 378938 472 100499467 1031 105377007 1647 1874 22974 PMC9249680__F2 Engineering Yarrowia lipolytica to produce nutritional fatty acids: Current status and future perspectives 2819 4018 5091 355 25913 PMC9250260__F3 p63 regulated pathway in cancer 6657 5371 581 324 847 PMC9251379__F4 Molecular Mechanism of Yellow Mushroom (Floccularia luteovirens) Response to Strong Ultraviolet Radiation on the Qinghai-Tibet Plateau 7909 2235 7054 4118 PMC9256076__F1 Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review) 3845 929 3098 586 4609 7351 759 948 PMC9256571__F1 Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease 2833 10803 58191 4283 3627 6373 10663 1234 1235 6370 6364 6367 1233 PMC9257096__F15 KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway 1000 999 3801 2475 1017 PMC9258696__F1 Osteoimmunology: The correlation between osteoclasts and the Th17/Treg balance in osteoporosis 4772 4318 100187907 1513 PMC9258700__F4 Gynostemma pentaphyllum against non‐alcoholic fibre liver disease based on network pharmacology and molecular docking 3630 2885 7249 6009 2002 572 355 PMC9259869__F1 Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis? 3486 3479 3484 3485 3667 3480 PMC9259951__F2 Trends in the Contribution of Genetic Susceptibility Loci to Hyperuricemia and Gout and Associated Novel Mechanisms 3174 80339 4036 3480 56606 2646 22877 51085 6781 10725 5174 9429 140805 7959 114548 7097 7099 PMC9261345__F1 NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction 472 545 10135 952 23411 23098 PMC9262756__F2 Aberrant expression of miRNAs in epilepsy 325 324 4851 4853 4854 4855 102 28514 10683 54567 3280 388585 PMC9262990__F14 Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer 4280 7454 3667 7124 2475 PMC9264948__F10 Prostate Apoptosis Response-4 (Par-4): A Novel Target in Pyronaridine-Induced Apoptosis in Glioblastoma (GBM) Cells 999 79923 6657 355 8772 7490 596 55075 51762 3091 1499 PMC9264955__F6 Prognostic and Predictive Role of Body Composition in Metastatic Neuroendocrine Tumor Patients Treated with Everolimus: A Real-World Data Analysis 2887 64798 64223 6009 7249 7248 PMC9266536__F1 Fenretinide in Cancer and Neurological Disease: A Two-Face Janus Molecule 5164 5915 1998 PMC9266727__F1 State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan 2729 2877 5226 2539 7086 7015 30061 645 644 2235 PMC9267148__F6 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis 163050 6097 23456 5649 57231 374655 1211 9846 29094 6925 51351 284654 558 23035 1052 5159 1894 32 1457 51693 121536 23216 7046 64763 1277 9702 8928 440107 150483 9329 5992 10847 PMC9267148__F7 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis 3084 50855 2064 2065 57019 56288 7046 6464 4842 4087 4089 148 9372 3708 773 8928 6497 6498 1457 PMC9267148__F12 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis 4089 7046 4087 57019 4842 PMC9272524__F3 Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance 23410 50 92140 999 6648 PMC9272595__F8 Oncogenic receptor tyrosine kinase pathway with its downstream signaling pathways and small molecule inhibitors targeting different proteins of the network 2885 2475 1956 558 6098 PMC9274112__F3 HMGB1/TLR4 and IL-1B/IL-1R1 Signaling Pathways in Epilepsy 7099 4615 7189 PMC9277228__F2 Necroptosis and Neuroinflammation in Retinal Degeneration 8717 7186 81858 29110 8772 8737 11035 197259 4615 PMC9277821__F2 Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance 11143 4609 3624 10643 960 324 10413 5295 11184 4855 1499 2308 4670 7555 7422 8570 693167 7428 10273 5594 2638 PMC9279817__F7 MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6 650 121340 860 4086 4090 4089 4091 PMC9281180__F4 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases 3654 51135 114548 4615 718 23405 50507 948 6120 PMC9283712__F1 TNFA Inhibitors and Other Biologic Agents for the Treatment of Immune Checkpoint Inhibitor-Induced Myocarditis 8772 8717 7186 PMC9284488__F3 LPS-mediated atherosclerosis 7124 7099 4615 114609 PMC9284706__F2 Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death 8205 3091 84890 1493 942 941 940 24145 355 PMC9284792__F11 Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway 5430 51441 65057 5037 9690 5894 PMC9285942__F1 WNT/B‐catenin dependent transcription: A tissue‐specific business 2932 324 1499 PMC9286785__F4 BACE1: More than just a B‐secretase 23621 5728 6774 3667 5163 PMC9287557__F3 One carbon metabolism 1719 94081 81855 7298 6470 6472 54977 4524 4522 10797 441024 10840 160428 25902 PMC9288037__F1 Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents 5111 376267 1869 5144 1017 84617 252983 699 10551 142 2064 8626 10382 7534 10383 4609 596 2521 7157 10381 1956 113457 80344 4605 5091 11012 4841 440603 7431 6415 7015 4313 4000 4815 2697 5728 2167 5970 PMC9288709__F5 Transcriptome profiling and co-expression network analysis of lncRNAs and mRNAs in colorectal cancer by RNA sequencing 401237 613 930 6850 2885 5879 5728 5163 951 7248 7249 572 4193 4609 5934 150365 1977 PMC9289199__F2 Hepatoprotective and Hepatotoxic Roles of Sex and Sex-Related Hormones 5618 3479 200186 2492 3949 3156 PMC9289230__F1 Neutrophils: New Critical Regulators of Glioma 3146 375295 1655 355 PMC9289270__F2 LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization 285958 5321 104472715 100124700 3606 114548 55384 6774 55000 283120 10984 3065 724102 6778 4851 PMC9289522__F1 Distinct Cell-specific Roles of NOX2 and MyD88 in Epileptogenesis 4615 7097 51135 7099 114548 PMC9289614__F1 Editorial: Autophagy-Mediated Cell Survival and Death in Disease Progression and Treatment 8408 60673 9776 22863 10533 64422 9474 9140 PMC9292562__F4 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing 952 4280 7166 23411 4397 196 10135 PMC9292562__F2 Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing 23475 93100 5212 23098 952 203447 10135 PMC9294428__F4 Discovering gene regulatory networks of multiple phenotypic groups using dynamic Bayesian networks 1021 1386 2354 125050 3172 4792 3725 6908 2353 7020 7421 4086 5914 4087 1869 5468 PMC9294450__F3 Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells 23236 5091 387 PMC9295998__F1 Multi-scale model construction 2878 10413 4436 6647 2876 2877 6648 1805 1652 PMC9299105__F4 Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19 1003 3146 3603 3554 4615 7099 114548 3606 3654 51135 7189 PMC9300693__F7 Proposed mechanism by which thiostrepton modulates ferroptosis via the STAT3/GPX4 signalling pathway 23657 2936 6774 2879 PMC9300700__F4 Broad view of the role of Galectin-3 in microglia-associated neurodegenerative diseases 54209 348 10461 7099 64581 10457 834 114548 968 4397 PMC9300927__F6 Identification of circRNA–miRNA–mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot 1182 1871 3984 639 5045 7107 7436 8974 25946 9788 138151 11069 10642 55634 3949 2200 651746 7280 5133 116138 22801 60468 2619 8303 3939 3838 5295 10018 9516 6774 85415 7852 55240 6241 2201 5606 6659 23657 81578 1280 283078 56999 2152 5738 80312 341640 4982 7552 154810 1955 11057 4294 9021 9315 84171 361 1870 3037 56963 6696 PMC9301819__F5 Atopic dermatitis and Psoriasis vulgaris -specific DEGs segregate discretely based on unbiased pathway and network analysis 111753249 10376 100129387 4216 1123 1235 2589 868 23604 5355 9289 54674 1493 3516 57489 5908 9806 4267 330 10957 6659 4676 7227 5783 284207 8519 23365 388403 23710 51429 3725 7128 143903 1512 10581 3956 1052 1191 5763 112744 301 81618 100463498 9235 11320 56937 10563 3820 84174 2534 7076 115362 9636 2149 1368 3002 3902 678 914 6173 128553 1396 822 71 694 10578 9976 56675 64386 10800 924 283131 101929531 7316 6139 51669 55540 7291 8743 2625 6526 2495 6231 8543 79026 9258 6654 51594 55790 23224 54947 63892 164832 92565 94081 79144 57584 5613 7049 8707 9034 1051 7538 8407 PMC9303342__F2 Co‐option of stress mechanisms in the origin of evolutionary novelties 5241 5732 5734 PMC9304707__F2 What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells 8841 1956 1977 PMC9305838__F4 Dual Function of Par3 in Tumorigenesis 7074 5879 2064 PMC9306053__F3 Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review 2308 940 55669 4976 9927 PMC9306208__F4 Senescence in osteoarthritis: from mechanism to potential treatment 545 472 100507436 3133 3570 1803 PMC9308248__F3 Promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors 64223 64798 6009 7249 7248 PMC9310475__F1 Which patients are prone to suffer liver metastasis? A review of risk factors of metachronous liver metastasis of colorectal cancer 324 1499 2475 1956 2885 673 2638 PMC9312505__F12 Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation 2621 3569 6774 PMC9316959__F3 Molecular Targets and Signaling Pathways of microRNA-122 in Hepatocellular Carcinoma 1869 7029 4609 581 PMC9317022__F1 Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses 64127 64170 6850 10892 8915 4615 7099 7100 7097 3654 3656 51135 7189 3661 3665 51311 54106 51284 29110 1283 PMC9317325__F3 Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses? 920 7852 975 54587 51284 4615 7098 9242 3661 29110 3665 57506 3716 7297 9636 6041 PMC9318110__F2 New Insights into TRP Ion Channels in Stem Cells 4772 4086 759 389058 1499 54822 7226 3717 6774 PMC9318283__F9 Protective Effect of Eurotium cristatum Fermented Loose Dark Tea and Eurotium cristatum Particle on MAPK and PXR/AhR Signaling Pathways Induced by Electronic Cigarette Exposure in Mice 3569 100379198 196 PMC9320762__F2 Non-Canonical Programmed Cell Death in Colon Cancer 2879 833 2182 3658 7018 7037 8031 PMC9322395__F1 Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma 7421 1717 120227 PMC9323564__F13 Altered Transcriptional Regulation of Glycolysis in Circulating CD8+ T Cells of Rheumatoid Arthritis Patients 2475 7124 6520 5728 201163 6502 7054 PMC9324584__F2 Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma 7057 7058 7422 5155 80310 3569 7424 5159 PMC9325968__F2 Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens 7391 10682 324 941 942 3383 940 7535 27040 634 8934 5879 PMC9331826__F1 Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance 1846 1499 100133311 5243 6778 PMC9331941__F1 Immune Checkpoint Inhibitors in Cancer Therapy—How to Overcome Drug Resistance? 325 6774 941 942 695 940 201633 3902 5817 961 140885 100133941 PMC9335949__F7 Explore the Potential Ingredients for Detoxification of Honey-Fired Licorice (ZGC) Based on the Metabolic Profile by UPLC-Q-TOF-MS 2946 2944 2953 1545 2938 1588 1559 2936 2950 PMC9336020__F1 Myricetin: targeting signaling networks in cancer and its implication in chemotherapy 581 2475 4609 6774 57817 7189 23237 PMC9336529__F1 Clinical potential of the Hippo-YAP pathway in bladder cancer 4771 4485 60485 55233 92597 9113 26524 PMC9343252__F7 MiR-146a targets CD147 in ALK+ ALCL promoting increased energy metabolism 442891 6774 1051 238 PMC9346148__F1 腺苷/A2AR信号通路阻断在肿瘤治疗中的应用 84890 132 100 952 PMC9347431__F5 Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection 3661 6772 3716 7297 6773 57506 2833 3627 PMC9347991__F3 Comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate 23411 7099 3146 114548 3553 PMC9348941__SF2 Rutin and Quercetin Counter Doxorubicin-Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2 7124 9817 4025 PMC9355870__F7 SLC35B2 is a vulnerability in YAP1-driven MAPKi-resistant, BRAF mutant melanoma 347734 3084 1839 2621 558 1956 2065 10413 PMC9356669__F6 Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19 10379 59272 7113 3665 57506 3661 51311 51284 7099 7189 114548 PMC9357805__F2 Microenvironment That Regulates Vascular Wall Stem/Progenitor Cells in Vascular Injury and Repair 6774 7124 3550 7410 3579 998 5879 729230 PMC9358979__F1 Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus 114548 65018 3553 115004 PMC9359062__F1 Anaplastic lymphoma kinase-special immunity and immunotherapy 920 2475 238 6774 3082 8743 8741 10131 8205 3662 55509 PMC9359465__F2 Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment 3383 7412 6010 5879 7124 920 PMC9359802__F4 Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines 57506 7098 6041 PMC9362381__F4 Thrombosis leading to acute abdomen in corona virus disease- 19:A case series 100187907 3383 7412 7450 59272 PMC9364366__F1 Key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance 6611 1674 64781 2581 PMC9366312__F3 Overcoming Mycobacterium tuberculosis through small molecule inhibitors to break down cell wall synthesis 3623 95 4322 PMC9366716__F2 Cell wall and the response and tolerance to stresses of biotechnological relevance in yeasts 6768 116844 7514 4281 PMC9367256__F2 Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews 595 5728 2475 1950 PMC9367504__F1 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis 8717 7186 8772 PMC9367737__F2 Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies 648 1021 1019 4193 5728 51741 2932 PMC9369364__F3 TM4SF5-Mediated Regulation of Hepatocyte Transporters during Metabolic Liver Diseases 174 947 619501 8651 9021 6347 6352 9032 23411 PMC9371855__F6 Rosin Derivative IDOAMP Inhibits Prostate Cancer Growth via Activating RIPK1/RIPK3/MLKL Signaling Pathway 8737 8772 2879 3146 11035 197259 PMC9372833__F5 Occurrence of MYD88L265P and CD79B mutations in diffuse large b cell lymphoma with bone marrow infiltration: A case report 4023 4615 51135 3654 7189 84433 10892 8915 3535 7038 3492 4067 6850 973 974 695 2475 PMC9374671__F1 Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2 1571 4827 203447 142 23411 4837 PMC9376115__F3 Regulated cell death (RCD) in cancer: key pathways and targeted therapies 60673 8408 55626 22863 1499 65018 64422 10533 PMC9376318__F3 CXCL5: A coachman to drive cancer progression 6374 6662 2833 2932 6774 3579 PMC9376585__F2 Pyroptosis in inflammation and cancer 9825 10733 65018 114548 2879 140609 5610 1654 5335 54878 91039 22900 22861 115004 1991 3665 3553 PMC9376585__F5 Pyroptosis in inflammation and cancer 22900 79792 3606 5027 114548 1687 1636 3586 PMC9378776__F2 Tryptophan in Chlamydia trachomatis persistence 196 1544 1545 1543 3586 383 57491 PMC9386470__F1 BTK, the new kid on the (oncology) block? 613 4067 6850 930 847 695 4615 8915 4609 PMC9387879__F1 Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries 3146 3717 6774 PMC9388619__F2 Canonical G1/S pathway 7454 100187761 5925 PMC9389448__F2 Modes of action and diagnostic value of miRNAs in sepsis 54487 29102 5901 27161 PMC9390238__F2 An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy 652968 153129 9531 5728 1938 6009 3479 6194 1975 1977 PMC9390238__F6 An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy 367 5979 9531 5728 2475 PMC9390702__F1 Targeting KRAS: Crossroads of Signaling and Immune Inhibition 1956 2475 1019 6654 1021 PMC9393759__F2 Circulating inflammatory cells in patients with metastatic breast cancer: Implications for treatment 2191 961 958 140885 51284 729230 1435 PMC9395689__F5 RAGE pathway activation and function in chronic kidney disease and COVID-19 23411 3146 1729 4087 4088 PMC9395689__F7 RAGE pathway activation and function in chronic kidney disease and COVID-19 6279 3146 4018 6285 5340 351 PMC9396497__F1 MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury 4099 10371 84894 387 8829 7474 23476 PMC9402976__F5 Review of granulocyte colony-stimulating factor receptor signaling and regulation with implications for cancer 6667 7297 6774 PMC9403273__F1 Inflammation in hematopoiesis and bone marrow failure: What can we learn from mouse models? 7099 54106 7097 7098 8717 8772 11035 197259 116071 7124 PMC9403334__F3 Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint 90550 57380 8011 7222 PMC9405087__F2 Neutrophils and Neutrophil Extracellular Traps in Cardiovascular Disease: An Overview and Potential Therapeutic Approaches 3383 3146 7450 PMC9405250__F11 Polyphenols from Thinned Young Apples: HPLC-HRMS Profile and Evaluation of Their Anti-Oxidant and Anti-Inflammatory Activities by Proteomic Studies 9817 5447 3162 571 7295 PMC9406467__F3 Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer? 7443 11200 472 PMC9406578__F2 Targeting Heat-Shock Protein 90 in Cancer: An Update on Combination Therapy 472 3611 6774 PMC9407429__F6 microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells 7048 1432 7043 7189 90 91 659 3845 145258 658 3224 860 1482 PMC9409235__F4 mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease 2475 2735 619501 PMC9412366__F2 Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections 114548 29110 3661 7297 3716 6773 10379 PMC9414081__F10 Research progress on extraction technology and biomedical function of natural sugar substitutes 3156 3949 29850 PMC9414242__F1 Recent Advances in Nanoparticles-Based Platforms Targeting the PD-1/PD-L1 Pathway for Cancer Treatment 941 942 324 940 594857 PMC9424771__F8 Molecular mechanism of Epimedium in the treatment of vascular dementia based on network pharmacology and molecular docking 7124 7186 7187 8772 83737 836 1051 759 2353 7185 3726 3725 4311 4323 4314 64127 6401 PMC9424846__F3 Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection 57291 100124700 100506311 378938 541472 PMC9426031__F7 Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive niche 11166 8205 847 7054 9242 8178 PMC9428246__F2 Propofol on macrophage activation and function in diseases 19 3170 55937 6714 2932 7099 3569 6772 114548 3596 3146 PMC9437103__F3 Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics 6722 2626 163732 2475 8408 9706 PMC9437975__F7 Integrative analyses of mRNA and microRNA expression profiles reveal the innate immune mechanism for the resistance to Vibrio parahaemolyticus infection in Epinephelus coioides 3075 100187761 64065 1431 4099 940 920 596 958 10803 29949 759 6347 PMC9438347__F14 Plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/Beta-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model 4040 4041 1499 7054 51527 324 999 595 2932 PMC9439649__F4 CAR T-Cell Therapy for Patients with Multiple Myeloma: Current Evidence and Challenges 7249 7248 2475 331 5163 4193 572 637 2353 1386 596 4170 595 898 4208 PMC9439914__F2 Biological Mechanism on SIRT1/NLRP3/IL-18 Signaling Pathway of Acupuncture for Treatment of Ischemic Stroke with Center Poststroke Pain 7913 170302 100188011 4117 3034 100187761 PMC9441765__F5 Emerging roles of ferroptosis in glioma 8678 23657 468 7036 2879 PMC9442031__F2 Influence of the gut microbiota on endometriosis: Potential role of chenodeoxycholic acid and its derivatives 1593 9420 1581 1582 570 25801 PMC9442203__F8 Anti-proliferation and apoptosis-inducing effects of dihydroartemisinin on SH-SY5Y cells and metabolomic analysis 730 717 718 729 727 PMC9442330__F2 Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders 5827 8443 8540 25979 4018 5091 PMC9442958__F10 ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NFKB pathway by the secretome 7424 3479 7124 PMC9446157__F2 Calcium signaling in cancer metastasis to bone 51393 4775 6786 6282 55503 7220 54822 10399 6714 3484 3480 PMC9448792__F8 Altered glucocorticoid receptor signaling in the diabetic proximal tubule 2289 2203 229 5105 PMC9448875__F7 Extracellular vesicles from colorectal cancer cells promote metastasis via the NOD1 signalling pathway 10392 6347 6346 998 PMC9448988__F2 Lung cancer in never smokers: Tumor immunology and challenges for immunotherapy 3458 7124 920 1956 940 3576 PMC9449932__F2 Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2 57506 3660 3665 3725 23118 4615 7189 7297 6045 10379 7054 4599 4600 4939 7082 27134 2705 100506658 1001 9636 PMC9450390__F1 DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy 6741 3001 5551 8205 PMC9453822__F2 Dietary polyphenols on cancer cell pyroptosis and the tumor immune microenvironment 6367 6774 8205 6387 PMC9454566__F8 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response 684 94240 10379 54809 115004 4938 3434 4940 219333 23122 847 5747 PMC9454566__F9 Anti-Tumoral Effect of Chemerin on Ovarian Cancer Cell Lines Mediated by Activation of Interferon Alpha Response 1240 54809 6503 9034 55601 25939 9636 920 10379 4599 684 4938 3665 8519 4939 4940 23126 PMC9455056__F1 MYCN and Metabolic Reprogramming in Neuroblastoma 3099 26227 2539 PMC9455056__F3 MYCN and Metabolic Reprogramming in Neuroblastoma 26227 29968 5723 4522 10797 PMC9455056__F4 MYCN and Metabolic Reprogramming in Neuroblastoma 5631 5471 2618 5198 10606 158 471 8833 790 7372 1723 4975 PMC9455275__F5 Identify metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 as potential prognostic markers and correlate with immune infiltrates in head and neck squamous cell carcinoma 59330 4609 5315 11113 4117 2717 11201 1537 PMC9456094__F2 PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review 5771 4280 348 100187761 942 7045 PMC9456318__F9 Integrated Analysis of Transcriptome and Metabolome Reveals Distinct Responses of Pelteobagrus fulvidraco against Aeromonas veronii Infection at Invaded and Recovering Stage 3630 5728 51701 6502 4193 246751 1017 664 10365 9140 472 PMC9457814__F2 Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches 367 7018 2475 157739 PMC9460496__F9 Transcriptional Memory in Taraxacum mongolicum in Response to Long-Term Different Grazing Intensities 2242 5091 729 PMC9464936__F3 Know when to fold ‘em: Polycomb complexes in oncogenic 3D genome regulation 9055 8314 54880 63035 340602 6595 PMC9465188__F1 Recent advances in the therapeutic efficacy of hepatocyte growth factor gene‐modified mesenchymal stem cells in multiple disease settings 3082 7412 7852 3383 50943 1901 581 PMC9467784__F2 Targeting Strategies for Aberrant Lipid Metabolism Reprogramming and the Immune Microenvironment in Esophageal Cancer: A Review 2475 6774 2194 718 55902 324 2033 1956 7099 PMC9468722__F3 Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review 9227 157506 346673 8854 1382 PMC9468871__F4 Network-based pharmacological investigation to identify the mechanistic regulatory pathway of andrographolide against colorectal cancer 3479 5743 5468 3791 1956 207 3717 2033 6714 6774 836 2475 4193 2099 3265 367 3815 142 5594 5781 7099 5295 3569 PMC9469902__F3 COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy 3716 10379 6773 619537 7297 PMC9474891__F2 Role and regulatory mechanism of m6A methylation in the nervous system 57721 56339 3181 79068 3183 2475 6432 4255 2305 3099 154 9589 3485 PMC9477010__F1 Pyroptosis and its crosstalk with immune therapy in breast cancer 114548 22861 9447 79792 3146 56169 1687 3001 3002 55876 PMC9477422__F7 Ptprh mutant mouse tumors failing to dephosphorylate EGFR 1956 2549 1017 5794 PMC9477829__F1 Exosome biosynthesis and uptake pathways 8027 967 11031 PMC9479684__F2 When does hepatitis B virus meet long-stranded noncoding RNAs? 115004 54106 4615 51311 51284 7098 64127 57506 6041 PMC9479684__F3 When does hepatitis B virus meet long-stranded noncoding RNAs? 3454 7297 2353 3660 3455 3716 3717 3459 3460 3588 684 105221694 PMC9479684__F5 When does hepatitis B virus meet long-stranded noncoding RNAs? 11126 54106 79885 6774 100124700 84206 3458 1655 8847 5970 PMC9482625__F3 Cellular composition within the TME and the effect of EMT on TKI resistance 1499 7291 9839 6935 4089 4087 4088 3082 558 7039 6347 2069 6359 999 PMC9482625__F4 Impact of tumor metabolic reprogramming on TKI drug resistance 5315 26227 3082 5728 2271 6510 1956 6667 948 2194 PMC9484011__F2 Biosynthetic pathway leading to H2S production from L- and D-cysteine 875 847 1610 PMC9484255__F4 Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response 545 472 115004 8289 PMC9484965__F9 Quantitative Expression of SFN, lncRNA CCDC18-AS1, and lncRNA LINC01343 in Human Breast Cancer as the Regulator Biomarkers in a Novel ceRNA Network: Based on Bioinformatics and Experimental Analyses 581 572 3479 4193 PMC9485288__F8 G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction 9908 3383 7412 27063 PMC9489753__F2 Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells 6347 6376 1524 3553 729230 89780 7422 6774 PMC9490123__F1 DNA damage, inflammation and aging: Insights from mice 115004 1362 6741 84126 472 545 PMC9490147__F5 DNA repair as a shared hallmark in cancer and ageing 472 641 4361 5888 1763 545 84126 7518 50485 54840 11284 7515 5429 7508 7507 PMC9491322__F10 Organic acid metabolism in Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] is controlled by a complex gene regulatory network 5183 4191 6476 PMC9495572__F1 Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease 571 4094 9817 PMC9495760__F1 Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? 3643 3667 3569 3553 PMC9496650__F2 Inhibition and potential treatment of colorectal cancer by natural compounds via various signaling pathways 324 8312 1499 2932 PMC9496810__F7 White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy 4040 4041 324 1499 PMC9496836__F1 Sirtuin 1 in Host Defense during Infection 23411 9474 10533 2475 7040 PMC9499548__F4 Two Short Repeats in the 5′ Untranslated Region of Insulin-like Androgenic Gland Factor in Procambarus clarkii (PcIAG) That Regulate PcIAG Expression 1855 4342 759 387 8454 3727 3725 51701 PMC9499793__F15 Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves' Orbitopathy 596 581 2475 PMC9500187__F2 Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms 4193 1021 1019 PMC9500666__F8 Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells 4703 22926 596 581 468 PMC9501218__F5 MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells 7097 7098 7099 PMC9501315__F2 Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology 9817 7450 2475 596 PMC9502172__F8 HSP27 Attenuates cGAS-Mediated IFNB Signaling through Ubiquitination of cGAS and Promotes PRV Infection 115004 29110 3661 PMC9502927__F1 Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes 64781 1674 410 PMC9503837__F2 Histone acetylation dynamics in repair of DNA double-strand breaks 472 9656 3150 PMC9504399__F3 Feedback Regulation of Signaling Pathways for Precise Pre-Placodal Ectoderm Formation in Vertebrate Embryos 4089 4090 4086 340419 4091 4092 25805 57154 PMC9513149__F1 DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology 472 545 2626 595 1021 1019 1017 PMC9513432__F3 How sphingolipids affect T cells in the resolution of inflammation 95 29956 717 253782 PMC9514424__F7 Multiomic analysis of dark tea extract on glycolipid metabolic disorders in db/db mice 283871 5091 4050 6955 4049 175 3600 11283 23237 PMC9515549__F1 Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17 10128 100187761 388796 1021 6774 1316 1499 494333 PMC9516650__F1 Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer 3845 1956 5290 673 5894 2475 PMC9516679__F9 Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between lamininG2 and integrinB1 999 3918 1000 PMC9519149__F2 Cholesterol biosynthesis pathway, the enzymes involved in the synthesis and the diseases associated with the defective enzymes 1595 1718 6309 10682 1717 PMC9519344__F4 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes 9140 10533 9474 83734 468 664 PMC9519344__F5 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes 468 22926 7494 7019 PMC9519528__F1 Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency 2531 1674 64781 4026 9350 PMC9519863__F2 Gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis 8213 1582 56848 2920 3579 114548 4015 9965 4615 7099 3606 PMC9520190__F3 Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma 2885 3479 3481 3480 3667 8660 5728 5163 PMC9520296__F2 Pyroptosis as a candidate therapeutic target for Alzheimer’s disease 28 3553 2932 4094 114548 79792 57103 PMC9520939__F4 Meta-transcriptomic comparison of two sponge holobionts feeding on coral- and macroalgal-dissolved organic matter 7187 57103 10163 84263 83871 57504 29997 80232 9863 51701 7003 9894 9601 840 836 154865 4553 79633 4841 51135 7189 PMC9522918__F4 Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma 230 7054 100187761 PMC9523361__F5 Tuning Rex rules HTLV-1 pathogenesis 1506 1386 3458 3558 PMC9523483__F2 OncomiRs as noncoding RNAs having functions in cancer: Their role in immune suppression and clinical implications 574482 3383 4277 100507436 7124 1499 PMC9524011__F2 Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis 5728 26471 55363 693222 1950 1956 7018 3976 6774 7471 1499 PMC9524955__F7 Study on the mechanism of warming yang and reducing turbidity decoction in the treatment of diabetic kidney disease based on network pharmacology 183 4087 4088 4089 2308 1958 6401 7018 5300 PMC9530148__F3 Astrocytes in neuropathic pain 3976 1270 56963 387 5879 6774 10215 1901 2935 4318 4313 6347 2919 PMC9530249__F2 NFKB and its crosstalk with endoplasmic reticulum stress in atherosclerosis 90865 948 7099 114548 PMC9530844__F7 Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin 2885 2549 1956 PMC9531511__F4 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis 11201 115004 3661 29110 2879 PMC9532118__F1 E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration 57154 4087 4088 4089 4091 4092 5914 4090 4086 7124 PMC9532536__AF1 Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway 2 5347 2305 10112 891 983 PMC9532536__F8 Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway 2 5347 2305 10112 891 983 PMC9533135__F8 Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells 4782 2248 2255 6657 3416 PMC9533616__F3 lncRNA PVT1: a novel oncogene in multiple cancers 10413 3091 5820 51129 3099 10507 26135 81671 554212 3619 8408 64422 100302175 90780 6469 4255 PMC9533616__F5 lncRNA PVT1: a novel oncogene in multiple cancers 5274 7421 26523 6778 7227 100302185 2305 5820 6774 3717 2260 2247 4088 402 1893 PMC9533616__F8 lncRNA PVT1: a novel oncogene in multiple cancers 4208 3480 5063 26585 7253 5820 5972 5725 7009 6928 10533 6657 2000 596 3099 2078 PMC9536081__F6 Absence of ID2 results in an altered photic responsiveness of the circadian system 3398 9575 5187 PMC9537025__F1 Mass spectrometry-based approaches to explore metabolism regulating ferroptosis 2729 2182 10162 2879 4015 2643 1723 PMC9540430__F8 Transcriptomics for child and adolescent tuberculosis 581 5970 175 3458 3460 3459 5771 7297 9282 10379 9636 4938 161247 3434 10581 4599 8519 PMC9548376__F6 Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle 867 1956 57680 4397 1017 PMC9548471__F1 Genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease 7297 6774 3717 9021 8651 PMC9548536__F3 Biomarker-driven feedback control of synthetic biology systems for next-generation personalized medicine 3570 3569 387 50616 6774 3588 3596 3565 6778 3586 PMC9549294__F5 Interleukin-1 receptor associated kinase 1 (IRAK1) is epigenetically activated in luminal epithelial cells in prostate cancer 2120 51513 30832 285676 79175 7743 348327 125893 346171 55659 147687 256051 6772 55762 6608 55422 63934 113835 7562 57677 7694 57693 148327 3034 10488 4791 2353 6955 7157 2113 7113 2078 2115 2118 2119 2005 3725 4609 6935 860 6667 2114 6929 2130 2313 5079 51274 PMC9552847__F7 PTEN loss promotes Warburg effect and prostate cancer cell growth by inducing FBP1 degradation 2203 5728 5163 6502 PMC9553876__F1 Molecular pathway changes caused by TTFields on glioma, GBM, MPM, NSCLC, and breast cancer Fig. 1A, Gliomas and glioblastomas 2475 115004 9447 387 672 PMC9553876__F2 Molecular pathway changes caused by TTFields combined with radiotherapy or drugs in GBM, MPM, NSCLC, and breast cancer 2177 672 2175 3725 6774 PMC9554349__F3 Genetic and pharmacological tools to study the role of discoidin domain receptors in kidney disease 1499 780 6774 948 PMC9556725__F1 Neurobiology of pain and facial movements in rodents: Clinical applications and current research 9311 7442 627 PMC9557158__F9 MiR-21 and let-7 cooperation in the regulation of lung cancer 79727 389421 5324 PMC9557197__F1 Ferroptosis in glioma treatment: Current situation, prospects and drug applications 55240 2182 4015 6520 2879 2937 PMC9559691__F5 Metabolomic Analysis of the Takifugu Obscurus Gill under Acute Hypoxic Stress 3630 3643 2885 5728 5163 5164 6774 4089 51701 4088 6502 4193 1017 7874 PMC9559691__F6 Metabolomic Analysis of the Takifugu Obscurus Gill under Acute Hypoxic Stress 2475 3630 6520 4040 4041 2885 2887 2932 3667 153129 51256 5163 201163 5728 6009 220441 6502 253260 64798 9675 PMC9562224__F11 HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1A/HEY1 Signaling Pathway 23462 340451 1003 7450 3791 PMC9563451__F2 Colorectal Cancer and Purinergic Signalling: An Overview 24145 84890 100 952 PMC9563910__F1 Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise 2597 2539 6120 PMC9564311__F5 Potential Fatty Acid Metabolism-Related Gene Signature for Prognosis in Clear Cell Renal Cell Carcinoma 10449 33 1376 224 3248 2026 2027 1371 PMC9568463__F8 HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress 8924 1386 6647 6648 2876 PMC9569951__F1a Roles of Androgens in Humans: Biology, Metabolic Regulation and Health 3931 6750 7054 367 PMC9569955__F7 Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation 613 29760 11184 6780 7706 23 7412 7187 3437 140739 57506 7189 29110 3661 PMC9570066__F7 Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio 6770 2353 5894 PMC9570383__F2 Metabolic Reprogramming in Tumor Endothelial Cells 2147 5209 3099 5019 440 2744 7006 100124696 1374 26227 29968 PMC9573482__F7 Quercetin and Resveratrol Differentially Decrease Expression of the High-Affinity IgE Receptor (FcERI) by Human and Mouse Mast Cells 2885 27040 6850 4067 83939 PMC9573972__F1 Unraveling the mechanobiology of cornea: From bench side to the clinic 9429 6662 652 1499 4609 6010 7045 PMC9574935__F1 SARS-CoV-2 accessory proteins in immune evasion 3716 7706 57506 3661 PMC9575701__F1 An emerging role for cellular crosstalk in the cancer stem cell niche 50943 3554 3611 3371 920 3976 8829 6935 5743 7422 7006 100124696 PMC9576946__F1 Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion 27086 113791 2475 4174 5111 983 PMC9576970__F4 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach 3579 3569 4321 7157 4792 4312 7124 3458 6772 6774 5743 3553 3725 2919 4316 6519 PMC9577160__F2 Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review 7078 5728 1019 7253 864 6476 PMC9578963__F1 Orchestrated signaling by PI3KA and PTEN at the membrane interface 5266 81609 4134 5728 4193 572 7249 7248 6009 5163 PMC9579211__F6 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways 102 6868 50863 PMC9579409__F3 Hepatic transcriptome profiling according to growth rate reveals acclimation in metabolic regulatory mechanisms to cyclic heat stress in broiler chickens 572 22944 7054 PMC9581404__F2 Adherens junction proteins on the move—From the membrane to the nucleus in intestinal diseases 1499 324 999 PMC9582773__F2 Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease 4353 847 9817 2934 54106 51284 1636 7113 7124 1401 PMC9587054__F6 Correction To: Signaling pathways in obesity: mechanisms and therapeutic interventions 23237 5697 885 5443 4158 4852 181 4159 4160 PMC9587056__F9 Hypothesis-driven dragging of transcriptomic data to analyze proven targeted pathways in Rhinella arenarum larvae exposed to organophosphorus pesticides 2353 196 4778 57491 405 9049 4946 4953 54498 6303 196743 493869 2937 847 2876 2878 1610 373156 221223 PMC9587083__F7 Hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer 2515 51741 9043 8692 3038 8372 3037 3425 960 2990 411 3161 23553 1462 PMC9588339__F5 Exploring Anti-Type 2 Diabetes Mellitus Mechanism of Gegen Qinlian Decoction by Network Pharmacology and Experimental Validation 7186 7187 3630 PMC9588458__F7 Working model of hyperglycemia in DCM 468 5602 596 581 PMC9588789__F7 Schema depicting the BET inhibitor resistance in PCa cells due to RB loss and hyperphosphorylation 23476 1021 1019 54584 PMC9589007__F6 Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues 2152 2155 7035 462 3053 2243 7018 350 2159 2147 2153 2161 2160 2158 7056 7450 2157 5627 10544 1361 710 5624 2149 2151 3827 5055 5265 5345 2 1506 624 623 5329 5328 5327 7123 3273 5473 7057 2335 5340 PMC9589293__F3 Temporal proteomic analyses of human lung cells distinguish high pathogenicity influenza viruses and coronaviruses from low pathogenicity viruses 3720 4621 25937 56138 3588 201798 64792 10664 5826 16 84059 80777 10290 1387 90407 23418 50619 3157 1237 11237 1608 1499 4609 91612 6929 8110 57645 945 114827 55703 56849 9493 57180 10929 494115 140564 55132 100187761 PMC9589344__F1 Targeting aldehyde dehydrogenase for prostate cancer therapies 5914 5915 216 595 5163 2932 1499 4089 4087 4088 22933 54567 PMC9589357__F4 Transcriptome analysis of malate-induced Schizochytrium sp. FJU-512 reveals a novel pathway for biosynthesis of docosahexaenoic acid with enhanced expression of genes responsible for acetyl-CoA and NADPH accumulation 355 2597 4199 1329 5091 1431 6389 PMC9592740__F2 Kölliker’s organ-supporting cells and cochlear auditory development 6217 1284 3725 1513 1292 2475 59330 79192 4059 348 6446 PMC9592792__F3 Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids 338 7038 64241 64240 26998 PMC9592993__F6 Integrating network pharmacology and experimental verification to decipher the immunomodulatory effect of Bu-Zhong-Yi-Qi-Tang against poly (I:C)-induced pulmonary inflammation 1380 367 4322 3569 5743 136 7421 5328 6850 1017 3791 5970 2185 7099 3932 330 6097 2147 50507 27250 54106 2033 3551 7157 154 2100 2247 4318 598 7422 1956 5294 2322 4314 5747 7054 2152 196 3685 5914 6868 5241 8517 7046 5027 354 3815 581 51135 5465 2475 3105 5159 6714 331 4609 4893 7852 6774 5156 2353 3579 6401 2597 5340 4915 2539 1520 5467 1508 5468 5578 7124 PMC9593054__F3 NLRP3-mediated pyroptosis in diabetic nephropathy 2146 1958 2308 2475 10628 114548 79792 PMC9593054__F4 NLRP3-mediated pyroptosis in diabetic nephropathy 10419 79792 378938 9817 1994 140609 114548 PMC9594894__F9 B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma 4283 3659 3627 8705 2475 PMC9595552__F4 Pyruvate metabolism–original version 4191 5106 5091 2271 4200 10873 4199 39 5313 5315 5162 1737 31 32 197257 3945 3948 134526 55902 1636 9380 3029 84264 84532 97 98 219 224 501 PMC9597306__F5 Recent advances in hydrogels-based osteosarcoma therapy 1499 4313 650 860 PMC9597993__F2 Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy 3002 3716 3717 22925 324 53832 29851 717 6774 6657 53833 29949 11009 PMC9597993__F6 Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy 920 7040 27250 2475 PMC9598867__F1 Redox-Regulation in Cancer Stem Cells 430 8313 6657 7422 3162 5052 8549 2535 2932 1499 960 6469 6608 79923 595 7001 PMC9598921__F4 Chromosome-Level Assembly of Male Opsariichthys bidens Genome Provides Insights into the Regulation of the GnRH Signaling Pathway and Genome Evolution 4313 2885 998 1958 PMC9600461__F3 Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells 89780 627 761 759 7473 7472 100187761 2932 9242 7471 7477 PMC9600986__F2 Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment 5447 4318 100187761 PMC9600997__F8 TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40 958 7185 7187 7189 581 637 PMC9602304__F2 Emerging Role of MicroRNAs and Autophagy Mechanism in Pancreatic Cancer Progression: Future Therapeutic Approaches 2475 8408 10533 60673 9776 8678 9140 83734 55054 64422 442917 574473 406892 693215 PMC9603851__F1 TLR4-Pathway-Associated Biomarkers in Subarachnoid Hemorrhage (SAH): Potential Targets for Future Anti-Inflammatory Therapies 3661 100187907 3654 51135 23118 257397 7097 7099 3569 PMC9603893__F3 Integrin Alpha v Beta 6 (AvB6) and Its Implications in Cancer Treatment 5879 7448 7939 PMC9604348__F10 Transcriptomic and Physiological Analyses Reveal Potential Genes Involved in Photoperiod-Regulated Beta-Carotene Accumulation Mechanisms in the Endocarp of Cucumber (Cucumis sativus L.) Fruit 64326 4602 1457 PMC9604790__F3 Integrating Genetic Alterations and the Hippo Pathway in Head and Neck Squamous Cell Carcinoma for Future Precision Medicine 2195 4485 26524 9113 4771 60485 1956 967 5879 23513 387 5784 960 1022 23476 PMC9605952__F1 Regulating pathways of ferroptosis 4613 8314 55240 246 6303 23657 56624 6657 26528 5937 6520 2879 9817 10524 6714 1499 8324 3934 10365 PMC9605952__F3 Autophagy on ferroptosis 22818 8031 10533 9474 3091 2879 PMC9606402__F5 Gadd45b in neurologic and neuropsychiatric disorders: An overview 4616 2475 581 627 2596 PMC9607910__F1 Applications of Exosomes in Diagnosing Muscle Invasive Bladder Cancer 2261 1029 7015 5925 PMC9608206__F2 Clinical implications of the interaction between PD-1/PD-L1 and PI3K/AKT/mTOR pathway in progression and treatment of non-small cell lung cancer 5728 1499 4601 6774 4609 1977 PMC9608343__F1 Metabolic features of myeloma cells in the context of bone microenvironment: Implication for the pathophysiology and clinic of myeloma bone disease 5741 860 89780 7480 64146 9242 PMC9610969__F2 Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer 581 1499 595 PMC9616778__F8 Cilostazol Alleviates NLRP3 Inflammasome–Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories 8989 114548 2670 23411 627 PMC9646898__F4 Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance 8717 8772 6868 7186 23118 3725 7185 7187 9618 2353 PMC9673319__F3 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease 102 81609 23621 55690 PMC9673319__F8 Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease 22986 351 5664 5663 28 4803 5662 9463 PMC9682260__F4 Alteration of cholesterol distribution at the plasma membrane of cancer cells: From evidence to pathophysiological implication and promising therapy strategy 3265 960 8772 324 PMC9688455__F1 PARP Inhibitors in Cancer Immunotherapy: Potential Friends to Immune Activating Molecules and Foes to Immune Checkpoints 942 941 545 472 1111 920 PMC9735758__F3 IL-1RAP, a Key Therapeutic Target in Cancer 3553 3556 5170 27179 27177 4615 51135 3656 3654 7189 23118 257397 10454 90865 9846 PMC9880437__F1 Pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine 114548 79792 9447 847 58484 3553 PMC9941074__F2 Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19 7297 3716 6773 6772 10379 1636 59272 114548 759 29949 57506 3661 3665 7113 7187 29110 7098 51311 51284 7189 PMC9957752__F13 Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease 2308 3667 8660 64399 5727 6608 PMC10030510__F4 Metabolic regulation of dendritic cell activation and immune function during inflammation 29110 3099 355 2475 PMC10037657__F1 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer 5465 2475 283120 8772 619501 PMC10037657__F2 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer 283120 998 5058 7291 6935 619501 3984 5594 PMC1186689__F1 Interferon-Gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes 3458 3716 3717 1386 4513 PMC1190322__F10 CdGAP mediates cross talk between the Ras/MAPK pathway and the regulation of Rac1 activity 2885 126669 7074 5879 PMC1195968__F1 RSV binding and triggering of cellular responses 3661 7099 4615 PMC1201344__F4 Fasting effects on fatty acid composition 120114 2196 2195 79633 PMC1201361__F6 Anandamide as an intracellular messenger inducing Ca2+ influx via TRPV1 7442 2166 275 PMC1234333__F7 Knockdown of Smad4 affects only a subset of TGF-Beta-regulated target genes and functions 4089 3726 861 2004 3280 6591 6659 2625 10370 10276 8728 9590 4616 3694 57154 1746 PMC128142__F1 Proposed biosynthetic pathway of GPI in the ER of P 2695 5277 2813 93183 9488 PMC129737__F5 Model for repair of camptothecin-induced replicative damage 55775 5810 7150 PMC133602__F6 The yeast glyoxylate bypass pathway and its possible connection with other predicted changes 48 4190 3417 3418 9377 PMC1350949__F7 Proposed model of the HCMV-induced apoptotic signaling pathways 545 472 581 842 836 PMC1360652__F6 Working model for the effects of 15d-PGJ2 and thiazolidinediones on TNF-stimulated NFKB activation and COX2 expression 7124 4513 5468 PMC1380241__F1 CoQ10biosynthetic pathway with eight known biosynthetic enzymes denoted as COQ1–COQ8 27235 51805 51004 84274 10229 PMC138773__F1 EGFR transactivation by GPCRs and cytokine receptors 1956 3717 6714 PMC140665__F8 Interaction between the Wnt/Beta-catenin and Wnt/Ca2+ pathways 7471 7474 1499 51701 PMC1435694__F1 Chemistry of the retinoid cycle reactions in the vertebrate retina 5995 6121 6120 PMC1475884__F2 TNF receptor (TNFR) pathway of signaling 8717 7186 8772 7185 PMC1489534__F3 Regulation of cell wall gene expression during the cell cycle (A) and in response to external stimuli (B) 59272 2619 2928 6688 PMC1502028__F4 EGFR and mTOR signaling network, and signaling mediator effects associated with rapamycin and/or EKI-785 treatments 1956 6774 5728 7248 2475 1977 PMC1522081__F7 Involvement of MACF1 in the Wnt/Beta-catenin signaling pathway 847 2932 324 PMC15871__F3 PI3′K signaling modules in mammals and nematodes have implications for cancer 5728 207 208 PMC1603666__F9 Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling 1950 7248 7249 2475 6009 PMC1681468__F6 Combinations of multiple states of complexes 3084 9542 2065 PMC1683566__F5 Integration of gene expression with the proposed mechanistic pathway initiated by comfrey treatment leading to tumorigenesis 2950 2940 1581 4363 8714 2947 23457 1906 4313 1284 351 5329 6275 7010 8743 7040 6696 5601 5054 3685 1026 8870 3162 4843 898 3624 1950 7357 729230 154 3082 3849 3850 3851 3856 3852 3855 467 183 3479 3976 1647 596 7508 2705 7076 PMC1698524__F5 Model linking HSP70 induction to p33ING1b-induced apoptosis 8717 5901 8772 581 PMC1698527__F10 Model for the transduction of DNA damage signals to the splicing machinery 545 472 83860 6872 6873 6874 PMC1766317__F5 Model: A similar CARMA-Bcl10-MALT1 signaling pathway mediates NFKB activation in response to antigen receptor stimulation in lymphocytes and AT1R stimulation in liver cells 8915 10892 3553 PMC1780025__F2 Heterogeneity of Pacemaking Ability among SCN Neurons Robust rhythm generation in SCN neurons 1407 1408 406 PMC1797633__F1 Strategies of the different HCV proteins to antagonize IFN therapy 3661 3459 7098 6773 6772 83939 PMC1847380__F15 Signaling pathways mediating the roles of Rho1 in cell wall assembly and actin organization 6094 116844 6493 717 11043 PMC1847401__F4 Genes of the insulin/IGF-2 signaling pathway are required for induced stress resistance and induced life extension 5163 207 6446 PMC1849962__F5 Regulatory networks model of GSL biosynthetic pathway in Arabidopsis accession Columbia 867 4397 2147 2160 PMC1852964__F2 APC-Beta-catenin-Tcf (Wingless-Wnt signaling) pathway 1499 2064 999 324 PMC1856251__F3 Molecular characterisation of non‐absorptive and absorptive enterocytes in human small intestine 2033 699 7040 4193 545 9184 2932 472 219972 10744 9232 6502 5925 7157 146059 324 11200 10459 991 5111 995 993 9134 8900 891 9133 894 890 902 1017 1019 85417 1021 5347 990 4661 8556 8555 8317 140739 PMC1866250__F7 Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance 7038 847 8694 PMC1899305__F7 GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS 929 114609 4118 4615 3654 7189 54472 PMC1919358__F5 WNT signalling KEGG pathway consisting of three subpathways with the genes on the microarray encircled (A) and expression profiles of genes during porcine myogenesis (B) 1499 1460 6929 PMC1933158__F6 A hypothetical model for the dual roles of insulin signaling in human brain 3416 4609 5080 63973 PMC19384__F10 A model of thymic differentiation 920 3575 978 PMC1951379__F6 IFN signaling during the clinical evolution of SARS 3466 3716 3717 7297 6772 6773 1356 340451 6890 8519 3437 PMC1974887__F1 Endogenous Synthesis of Coenzyme Q in Eukaryotes 27235 51805 51004 84274 PMC198547__F8 Leptin action on the TRH neuron 5443 181 4160 4852 6774 PMC1998879__F2 Molecular pathway associated with neuronal migration 1641 1600 81565 7436 PMC204456__F5 Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans 57493 1956 9541 2885 PMC2064840__F9 Divergent TGFB signaling pathways induce transcriptional regulation through Smads and translational regulation through the mTORC1 pathway 4087 4088 4089 PMC2148057__F6 Sugar metabolism pathways in MCF-7 and ZR75-1 cells profiled by GenMAPP 230 5226 7086 5618 5091 PMC2238789__F2 a Cell processes predicted to be influenced by the top up-regulated priority genes (164 genes showing a differential expression >1 log2) based on in silico analysis employing the ResNet database (PathwayStudio 5.0, Ariadne) 57486 3399 1356 5649 666 4094 PMC2238877__F4 PharmGKB Irinotecan Pathway 1066 8824 590 55775 4790 7515 7150 54658 54659 54600 1244 5243 9429 PMC2254980__F3 Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice 7038 4018 1376 79071 355 PMC2266095__F2 Schematic presentation of the NFKB signaling network in radiation-induced adaptive radioresistance 472 4616 6741 331 PMC2268796__F6 The signaling pathways regulating cell cycle and differentiation in tumor cells in response to shear stress 4086 4090 983 891 860 PMC2270259__F3 Central metabolism 100188864 4118 11113 PMC22753__F6 A signal transduction pathway leading to the phosphorylation and activation of mTOR in response to insulin 5164 5163 2475 PMC2276341__F3 Network analysis of target genes 6938 4761 11243 59330 5279 7173 6424 3671 PMC2291295__F1 Keratinocyte Apoptosis in Epidermal Development and Disease 355 581 637 PMC2291295__F2 Keratinocyte Apoptosis in Epidermal Development and Disease 1950 3082 4803 1956 572 PMC2361115__F1 Cytoplasmic/traditional and nuclear modes of the EGFR signalling pathway 1956 1950 6774 1869 595 PMC2386920__F7 IRF-5 in the innate antiviral response 3663 54106 51284 23586 4615 7189 3654 29110 3661 PMC2391280__F1 A signaling pathway AKTing up in schizophrenia 207 1312 1813 1812 PMC2393790__F3 Citrate cycle genes are up-regulated in the brains of nurse bees 5091 1431 2271 47 6389 1743 1738 4967 PMC2395337__F1 5-Fuorouracil drug pathway demonstrating the interaction of multiple gene products 1807 1806 7372 1854 4830 4831 7083 6240 6241 7374 2271 1719 2356 7298 8836 7157 4524 4790 2232 PMC2427336__F9 A schematic summarizing ER stress response pathways in cells compensating for deficiency of the ER stress response kinase, PERK 7494 468 22926 PMC2432084__F9 p27Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells 2932 6502 1017 PMC2435382__F11 Hypothetical scheme illustrates the putative intracellular signaling cascades serving as the context for the data collected in the current study 4841 627 2885 PMC2443854__F1 The Essential Components of Nodal SignalingTGFB proteins are synthesized as pre-pro-proteins requiring cleavage of the signal peptide (black) and prodomain (orange) prior to dimerization of active ligand (red diamonds) 4838 2657 4088 4087 4089 8928 PMC2490815__F4 IL-12, IL-23 and IL-27 are heterodimeric cytokines signals through Jak-Stat pathway and induce Th1/Th17 differentiation and T-bet expression in T cells 3595 149233 3717 7297 6774 6775 3458 PMC2494582__F1 Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus 6010 2638 359 PMC2515871__F2 Roles of cis- and trans-Changes in the Regulatory Evolution of Genes in the Gluconeogenic Pathway in Yeast 4191 2203 5105 PMC2518078__F1 Cotargeting survival signaling pathways in cancer 2885 5728 5163 572 7249 7248 6009 1977 PMC2548289__F1 Hereditary Hemochromatosis in the Post HFE Era 3077 7036 148738 PMC2556276__F1 Display of differentially expressed genes in the uterine cervix after term spontaneous labor mapped on the PLAU signaling pathway 5327 5270 5340 5328 7448 3082 4691 5329 1956 6714 2549 3716 3611 2885 6772 5894 2002 3265 PMC2563180__F3 The cardiofaciocutaneous syndrome 3265 3845 673 PMC2567408__F8 NCAM upregulation leads to a functional switch 126669 2534 10818 PMC2570545__F2 EGFR signalling pathway in lipid rafts 1956 5266 5091 5163 2475 572 PMC2572856__F1 Aging of signal transduction pathways, and pathology 4838 4092 5728 324 6608 PMC2575905__F1 Current concepts of the amino acid signaling pathway leading to protein synthesis 7248 7249 6009 29904 1977 PMC2576557__F10 Schematic diagram showing the pathway involved in high glucose- and high insulin-induced extracellular matrix protein synthesis mediated by GSK3B and eIF2BE 2932 2475 1938 1977 PMC2577794__F1 Uncovering cryptic genetic variation in C 1950 1956 2885 102 8136 PMC2579774__F4 HIV-1 infected astrocytes and the microglial proteome 2752 3313 1958 7157 7707 6181 7555 2023 2760 PMC2586270__F6 Furin action in pituitary gonadotrope cells 4087 4088 5045 PMC2596245__F3 EET- or sEHI-mediated antihyperalgesia occurs through 2 distinct mechanisms 26136 4015 706 PMC2603552__F10 Role of oxysterol sulfation in lipid metabolism 412 6820 19 355 PMC2604897__F2 Putative biochemical pathways involving MGAT3 1356 6938 85451 PMC2607021__F4 Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease 2255 84708 64478 8650 222484 9253 817 8536 463 814 9759 PMC2615463__F1 Arc function in mGluR-LTD 29904 23237 1938 PMC2620272__F4 Bimodal genes that were switched "on" as a result of HIV infection in KEGG T-cell receptor signalling pathways 1493 3932 978 2534 948 27040 3702 286204 55937 1610 940 PMC2621116__F2 Representative plasmids used in this study 3045 100187828 2108 PMC2627788__F5 Wnt/Beta-catenin signaling pathway in leukemia 324 2932 1499 57167 4040 4041 PMC2629979__F1 Molecular Mechanisms in COPD pathogenesis and potential therapeutic targets 7045 1958 7040 9817 260431 PMC2634257__F1 Simplified schemes of the three Wnt signaling cascades 6010 23002 1499 51176 PMC2634812__F5 Schematic of counterbalancing and dose-dependent regulatory forces that act on T-cell precursors through the ETP and DN2 stages 4851 2625 5079 3398 6689 PMC2634968__F7 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling 4615 7096 7097 51311 10333 7100 81793 54106 7099 51284 92610 7189 3654 PMC2635020__F1 CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC PROTEASE 637 581 4791 PMC2637898__F3 EGFR signal transduction pathways 7039 1956 1950 1839 PMC2637898__F4 VEGF signaling pathways 7424 8829 8828 PMC2639747__F1 Smad3 in TGFB–induced antiproliferative transcriptional responses 4088 4089 1874 1875 6667 PMC2645860__F2 Pathogenetic mechanisms of CCAAT enhancer binding protein alpha (C/EBPA) dysfunction 4851 865 28951 613 10682 PMC2648516__F1 SKN-1 and the Wnt effector TCF/POP-1 reveals differences in endomesoderm specification 10940 90196 9968 5469 101180900 4397 PMC2649086__F7 KLF14-mediated TGFBRII silencing 136259 6667 25942 PMC2649571__F7 Beta-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in Motor Neurons 324 1499 10940 PMC2653622__F2 PRIMARY CILIUM: AT THE CROSSROADS OF MAMMALIAN HEDGEHOG SIGNALING 6608 2737 2736 51684 6469 PMC2658537__F1 Sample signalling scheme showing pathways known to be active in melanoma 5728 2475 673 7248 7249 572 PMC2666503__F1 F igure 1.— 10818 2549 2885 PMC2666548__F1 Reactions and proteins of the mitochondrial FAS pathway 95 9374 60496 27349 54995 11102 109703458 51102 PMC2667932__F1 Model for TGFB1-induced PAI-1 expression 1956 4087 4089 6010 4088 5494 PMC2671802__F1 ALPS and CEDS illustrate signaling pathways for lymphocyte apoptosis and activation 355 940 4893 8772 8915 5163 10892 637 PMC2674738__F1 Circulating blood monocytes adhere to activated endothelium at sites of disease or injury 5091 4018 729230 PMC2675004__F1 Crosstalk via the NFKB Signaling System 7124 4049 4055 355 6863 958 PMC2675552__F3 Mechanism of action of toll-like receptors (TLRs) 7096 7097 7099 3661 PMC2677061__F1 Postnatal Roles of GDNF Family Members in Nociceptors Plasticity 2668 4803 2674 2676 5979 PMC2677387__F1 mTORC1 activation by nutrients and growth factors 5728 2475 64223 253260 7249 7248 6009 PMC2679172__F1 Crosstalk at the initial encounter: Interplay between host defense and ameba survival strategies 717 1356 51083 7097 PMC2679427__F1 Regulation of rat GSTA2 and NQO1 gene expression 196 405 2939 1728 PMC2680287__F1 Unraveling the complexities of the interferon response during SARS-CoV infection 3447 3456 3458 3454 3459 3460 3716 7297 3717 6773 4792 4791 4793 6772 4794 64170 29108 10561 3428 4599 4600 4938 3434 3433 4939 4940 8638 64135 3437 3660 3661 7097 7098 7096 10379 3669 3664 3663 4790 3665 3569 3553 7124 6347 6352 1378 962 969 9308 8832 942 PMC2683106__F5 Promoting cell proliferation and repressing differentiation 901 2475 27250 83881 5308 64641 6657 PMC2684375__F1 Factors involved in the regulation of corporal smooth muscle tone 1267 2638 6010 PMC2686461__F1 BCR signaling pathway 613 1445 55824 4067 933 PMC2691592__F7 Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis 3364 1196 10419 PMC2691779__F1 Schematic overview of the human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) apoptosis pathway 8772 472 637 56616 331 PMC2694412__F6 Somatic mutations affect key pathways in lung adenocarcinoma 1956 3643 1029 4763 5728 4193 472 1499 7249 7248 5925 7157 324 2475 6794 PMC2698768__F9 Model of CD28 signaling pathways initiated by the distal and proximal motifs 940 5163 2932 PMC2700428__F2 Some cellular processes implicated in the pathogenesis of PAH 1950 659 3791 PMC2705893__F1 Protein kinase Cι: human oncogene, prognostic marker and therapeutic target 1950 3082 1956 6714 572 5879 5058 4609 PMC2706143__F2 The Endoplasmic Reticulum and the Unfolded Protein Response 22926 83939 7494 468 PMC2706143__F3 Endoplasmic Reticulum and the Unfolded Protein Response 468 22926 7186 842 836 100506742 PMC2709066__F1 De novo purine synthesis pathway 5471 5198 7808 158 PMC2709380__F7 Hypothetical model of transcriptional regulation of the p21 gene and p53 pathway 6667 57621 54880 PMC2709429__F11 Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin 948 27035 1644 PMC2712453__F2 G1-phase signaling pathways inferred with different heuristics 991 10518 375757 PMC2712453__F5 Erb-associated signaling pathways 613 2475 572 5091 PMC2712453__F7 Signaling pathway inferred from a gene regulatory network 64326 10282 998 84188 PMC2713566__F1 Mitochondrial pathways of electron flow resulting from the substrates and inhibitors used in this study 2242 4118 11113 PMC2720436__F1 Hippo pathway, a vital growth regulator of cell proliferation and apoptosis was initially identified by mosaic screens in Drosophila melanogaster (,) 4485 9113 332 329 4170 PMC2722148__F1 MAPK transduction signaling pathway 2263 2885 4214 2002 PMC2724047__F6 Activation of the Akt (insulin signaling pathway) and FXR by bile acids in hepatocytes 1956 6714 5163 PMC2726720__F3 Interplay of TGFB, Wnt/Beta-catenin, Hedgehog, and Notch in stem cell differentiation and tumorigenesis 4088 4089 1019 PMC2727567__F1 Unwelcome Complement 2271 720 718 5648 10747 PMC2727921__F1 Genetic polymorphisms, their allele combinations and IFNB treatment response in Irish multiple sclerosis patients 10148 3717 7297 6772 6773 5578 10379 836 87178 2633 840 8554 3952 3588 3587 3594 149233 3595 3460 3459 3454 PMC2728865__F2 Transcriptional Regulation of Metabolism Associated With the Increased Desiccation Resistance of the Cactophilic Drosophila mojavensis 2539 2597 5132 PMC2729268__F2 Map of protein interactivity (binding, regulation, modification) between genes revealed to be significantly associated with bladder cancer in urothelial cell samples 348 7804 64399 50848 467 7097 2782 183 7037 5294 267 2549 7046 2064 3953 655 2128 PMC2737697__F2 Genetic Susceptibility to Lupus: New Insights from fine mapping and genome-wide association studies 1401 7128 3663 3665 718 6775 613 7293 7292 26191 920 29126 PMC2738133__F3 Molecular Aspects of Moraxella catarrhalis Pathogenesis 7448 721 727 718 7097 634 5879 PMC2741134__F2 Inteferons pen the JAK-STAT pathway 6773 3455 3454 7297 3717 3460 3459 PMC2742785__F8 Cluster 2 genes significantly overlapped with those in the eicosanoid signaling pathway (P = 4.6E-05) 391013 64600 50487 30814 22925 5322 23236 242 5743 2950 2954 4048 5226 5730 4050 5228 1241 6915 PMC2743781__F3 NAD biosynthetic pathways from nicotinamde and nicotinic acid in yeast, invertebrates, and mammals 23057 64802 349565 10135 PMC2744640__F4 Regulation of Mitochondrial Respiratory Chain Biogenesis by Estrogens/Estrogen Receptors and Physiological, Pathological and Pharmacological Implications 6667 4899 7019 5225 4528 4553 PMC2746948__F1 Apoptosis pathway 355 8772 637 317 PMC2749448__F1 Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans 2734 55276 2203 7167 2819 2820 5230 2023 5105 54820 100996949 5131 3651 PMC2753670__F3 Integration of ITAM and cytokine Jak–STAT signaling 7297 6850 3716 6772 3566 PMC275444__F7 Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility 998 5879 5058 387 718 PMC2754932__F6 Model of Udu function in DNA damage response 4172 4173 472 PMC2757699__F1 Metabolic fate of the 13C-label from [1-13C]-glucose 3099 3098 355 PMC2759144__F4 Model depicting the E2Fs-FA/BRCA axis in the control of cell fate 2175 2176 2187 2178 2188 57697 2189 55120 1869 2177 672 PMC2759942__F5 Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity 847 652 650 PMC2760340__F2 Representation of NF1 interactions with the Ras and PI3K pathways 4763 5728 2475 2885 PMC2761008__F3 Cliques or near cliques from the cancer pathway related network Gp 598 6160 54606 4035 637 6165 7040 5934 8317 7042 472 7057 2335 4172 1476 3398 1017 632 4638 3400 9133 8871 1509 2547 1508 72 4087 2353 1471 6498 2017 2885 860 PMC2761207__F1 Major pathway of the conversion of propionyl-CoA into succinyl-CoA in human cells 166785 84693 326625 5096 5095 867 25974 PMC2769253__F3 MicroRNAs in cancer 1869 4609 4613 1870 1871 PMC2773630__F6 Molecular interactions during pheromone induced cell polarization 998 84188 983 PMC2777340__F4 Drosophila insulin signaling pathway 5728 5163 126669 2885 253260 7249 7248 6009 PMC2777484__F1 Folate-mediated 1-carbon metabolism 1719 6470 7298 PMC2780914__F3 Transmigration causes differential expression of genes in the apoptosis pathway 7124 4671 6093 2620 790 PMC2782452__F1 Different views of the Akt pathway/network 5728 572 2475 4193 7006 100124696 PMC2784255__F1 Examination of Tetrahydrobiopterin Pathway Genes in Autism 2643 2644 5805 6697 7054 5053 5860 5092 11113 PMC2790417__F10 Summary of proposed role for Foxa2, Nodal and Hh signalling pathways in ventral CNS development 3170 9423 8928 4838 PMC2790720__F2 IRF4: Immunity. Malignancy! Therapy? 3662 6319 6713 4609 1021 892 639 10923 10735 5091 PMC2792482__F3 Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs 7099 7098 3661 64127 7124 PMC2792912__F6 Model of Six2 function during mouse pyloric sphincter development 6476 652 657 10736 6662 PMC2795439__F1 Androgen-receptor signalling in normal prostate and PCa 1956 6774 367 PMC2796113__F2 Models of Merlin-dependent membrane receptor distribution in flies and mammalian cells 4771 1956 9368 1950 PMC2797270__F8 Summary of Trif-biased signaling and selective p38 activation by sMLA 3929 929 4118 29110 3661 4615 7099 PMC2797892__F10 Pathway induction after pathophysiologic stimulation of BSMC by three coordinate stimuli: strain, hypoxia, and damaged matrix 2475 3717 6774 1977 PMC2804114__F1 IR and IGF family signaling pathway 7249 2475 6009 PMC2805399__F8 A proposed working model of the complex Sertoli cell-germ cell interaction describing the mechanism by which Sertoli cells trigger germ cell apoptosis following MEHP-induced Sertoli cell injury 7077 4313 4790 6667 355 PMC2806113__F6 Working model of TGFB actions in renal interstitial fibrogenesis 5062 7248 2475 PMC2806370__F3 Pathway deregulation in ovarian cancer 6608 5914 65057 PMC2808051__F6 Mammalian target of rapamycin (mTOR) activation pathway 5728 2932 2475 717 6009 29904 1938 1975 PMC2808051__F20 Reversible phosphorylation regulation of the cell cycle 472 7465 1869 1870 PMC2808158__F7 Schematic summary of effect of IL-4 priming on phagocytic and secretory capacities of MΦs 4827 3566 3718 3716 3667 7189 PMC2810084__F7 TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice 7099 324 4615 PMC2812698__F1 Signalling pathways that regulate cell wall remodelling of Candida albicans 11043 4281 998 1255 PMC2814417__F7 The postulated signaling of MAP kinase pathway in proliferating or differentiating HL60 cells 8844 10682 929 101180900 7421 PMC2815088__F4 The Hexosamine Signaling Pathway 3667 5163 208 207 3479 5728 5164 9798 PMC2831005__F10 Yeast cell cycle 84188 1201 991 324 PMC2834432__F1 Phosphatidylinositol 3-kinase (PI3K) signaling cascade 5728 5163 64223 253260 2475 7249 572 4193 7248 6009 PMC2840158__F6 Schematic showing cytoplasmic signaling pathway from ATM to TSC2 via LKB1 and AMPK to repress mTORC1 and induce autophagy 472 7249 2475 PMC2841329__F1 Model for the role of ΔNp73B in the DDR 3014 10111 472 4193 PMC2846071__F1 Prevention trumps treatment of antibody-mediated transplant rejection 718 940 613 920 958 PMC2848237__F2 Reconstruction of a KEGG pathway 1201 991 990 PMC2849704__F1 Homocysteine metabolism in liver and kidney 84890 635 875 PMC2854249__F1 Mammalian autophagy: core molecular machinery and signaling regulation 55626 8408 7405 81671 58476 PMC2854285__F2a mTOR and cancer: many loops in one pathway 7249 7248 64798 100187761 PMC2858157__F7 Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration 672 10910 51514 9988 6230 6943 84285 4863 11080 10112 149628 673 3172 53918 8178 7110 83990 56647 91768 9113 9836 64065 55718 PMC2861491__F1 Destruction of the Beta-catenin (Beta-Cat) destructor Axin 324 1499 80351 PMC2864432__F3 Insulin/IGF1 signalling pathways and AD 3479 3480 126669 2885 572 PMC2865534__F1 Heterologous Expression and Maturation of an NADP-Dependent [NiFe]-Hydrogenase: A Key Enzyme in Biofuel Production 1356 3242 4553 PMC2868837__F3 Major gene products affected by virulent infection 4929 3552 3725 3164 3553 1958 2353 5743 1956 9173 7422 1959 7424 PMC2874116__F2 Intrinsic pathway is deregulated in cancer 1956 572 581 PMC2875058__F2 Several disease pathways involved in AD pathogenesis 348 1191 23268 8301 1378 23621 5663 255022 6653 PMC2875112__F1a Targeting Multiple Kinase Pathways. A Change In Paradigm 5728 4193 2932 572 PMC2875805__F10 Cartoon illustrates genomic and nongenomic actions of VDR signaling in inhibition of human CYP7A1 gene transcription in human hepatocytes 6714 6256 7421 9611 PMC2876151__F7 Cdk1 modulates the activity of several DNA damage checkpoint proteins 5985 5984 5983 5982 4361 983 4360 118027463 1763 991 PMC2878746__F1 Ret gene structure and signaling 5623 4902 9048 5979 10818 6714 PMC2878851__F1 Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures 5728 4094 891 4751 324 6678 991 4172 1026 PMC2878851__F3 Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures 2019 4313 6678 207 1387 7251 1871 898 4172 5111 51659 55388 9212 324 699 891 8317 6772 4134 5718 5728 PMC2881367__F7 CircleMap display of the ErbB2 pathway 2064 207 2065 9542 2475 PMC2882232__F2 Simplified representation of oncogenic signaling cascades in pancreatic cancer 3082 3480 885 1956 4040 6714 51527 324 5728 4089 1499 2475 PMC2882865__F2 Transcriptional regulation by E2F complexes modulates cell-cycle control, cell fate, and survival 1869 4851 3065 6839 PMC2886808__F1 Signalling through growth factor receptors can activate the PI3K/Akt/mTOR pathway and the JAK3/STAT5 pathway 3718 2475 50943 PMC2886982__F3 Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes 9448 1149 355 4023 PMC2889025__F2 P53 stabilization 4609 4193 472 545 PMC2889025__F4 Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization 5728 4193 545 472 PMC2891965__F8 Updates in the characterization of the COX-2 pathways in human neutrophils 4048 4049 4513 PMC2893101__F3 Apoptosis Signalling network 637 331 596 581 8772 8717 PMC2895650__F1 Multi-Variant Pathway Association Analysis Reveals the Importance of Genetic Determinants of Estrogen Metabolism in Breast and Endometrial Cancer Susceptibility 412 3290 1312 9 7363 10 2950 PMC2897923__F3 Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression 4920 6774 3814 960 PMC2901811__F4 II S and TOR-signaling pathway in Drosophila 5163 5728 7249 7248 6009 PMC2902148__F2 Inhibition of VEGF signaling pathways 7422 7423 7424 PMC2905230__F1 Simplified Overview of TLR Signaling 7099 929 51135 3661 3665 3654 3663 PMC2907165__F1 Type I IFN Signaling 3454 3455 3716 7297 3667 8660 7409 5879 10379 1399 2475 PMC2908768__F4 Cytokine signaling through the Jak/Stat pathway in mammary gland development 3565 3596 5617 5008 8651 9180 9021 6288 PMC2910789__F1 Selected IGF-axis genes that encode core components of IGF-axis upstream the PI3K/AKT/mTOR and RAS/MAPK/ERK pathway 3486 3484 3481 3488 3479 3480 8471 3667 8660 2475 PMC2912031__F4 Reciprocal inhibition mechanism by TGFB and IFNG 7048 7046 3459 3460 3716 3717 8651 4092 4087 4088 6772 4089 8554 PMC2912204__F1 PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001 5728 5163 7248 7249 6009 2475 PMC2921475__F1 Cord Blood Genomic Analysis Highlights the Role of Redox Balance 847 7001 7351 PMC2922475__F1 CD73: A novel target for cancer immunotherapy 84890 367 100 PMC2922498__F2 Schematic for DSB repair by HR and NHEJ pathways 5889 79728 672 353497 5888 7518 3981 PMC2923753__F2 Signalling pathways that regulate Candida albicansCHS gene expression 11043 4281 1255 PMC2928959__F6 Hypothetical model for EGFR-dependent loss of cell polarity and activation of Wnt signaling in CS-exposed human airway epithelium 4582 4040 4041 324 1956 PMC2929604__F1 Role of TLR4 in hepatic I/R injury 7099 4118 4615 3659 3146 3661 3627 PMC2931413__F1 Hermaphroditism in Caenorhabditis nematodes.(A) The Caenorhabditis hermaphrodite gonad 6382 6383 9672 PMC2933229__F3 The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas 4609 467 10215 PMC2937358__F1 ERAlpha-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches 1956 999 2920 2921 6372 PMC2938833__F2 Actin-cytoskeleton signaling pathway and the candidate genes involved in colorectal cancer progression in patients with ulcerative colitis 1950 2147 3929 929 2885 9138 23365 387 10458 10152 PMC2939393__F1 The Fe-S biogenesis proteins, ISCA and C1orf69 (Iba57 homologue), may impact heme synthesis by affecting the production of succinyl-CoA, a substrate of heme synthesis 200205 2242 5132 2235 212 PMC2939720__F1 Viral hijacking of the host ubiquitin system to evade interferon responses 7098 51284 54106 7297 3454 3455 3716 4615 6772 6773 7187 7189 10010 9636 29110 10379 684 3661 3665 PMC2940738__F7 ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans 3479 207 208 PMC2940871__F3 Metabolic reactions involving the PGM2 (adapted from ) 55276 6120 7504 7498 PMC2945784__F2 Cancer signaling pathways affected within the tumor 5154 5155 4902 1950 1956 5979 5728 6654 5170 3265 208 4824 207 5894 2475 57521 7157 1977 5925 2674 50964 PMC2948541__F5 Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders 581 467 604 7832 3164 266743 5055 3625 2308 10628 637 PMC2948663__F1 Molecular and genetic events in mammalian sex determination and differentiation 5087 2018 56956 84733 2516 7490 1761 2626 6736 50846 2254 5730 54361 6662 284654 668 268 PMC2954716__F4 Developmental Programming: Differential Effects of Prenatal Testosterone Excess on Insulin Target Tissues 3667 2475 253260 5140 2931 2932 1977 PMC2955993__F1 Complement and Periodontitis 716 717 718 4179 2271 1378 727 966 PMC2955993__F3 Complement and Periodontitis 727 7096 7097 PMC2956378__F7 Thrombin-induced ET-1 secretion in RPE is rho/ROCK1/2 dependent 6093 9475 2626 2624 PMC2957678__F1 Schematic view of HMGB1 signal transduction 3146 4609 4193 5728 PMC2963118__F2 HRS cell and its cellular microenvironment 6352 3458 6772 8205 PMC2964899__F5 Cellular events and signaling elements involved in the regulation of SHH expression, GLI activation, and mediation of the Hh activation-induced cellular response 1950 3552 6095 6469 1956 5156 1499 2735 PMC2964899__F6 Scheme showing the signaling elements and frequent deregulations in the Hh signaling network and potential cross-talk with the EGFR signaling pathway involved in the malignant behavior of cancer cells 6469 100187761 6608 8315 3240 64399 PMC2966904__F7 Proposed scheme of the signaling pathway by TfR2 and HFE 7018 3077 148738 57817 5045 PMC2974067__F1 Signaling pathways that regulate longevity in C 65095 5163 207 6446 208 PMC2974775__F4 Ca2+ waves activate transcription factor NFAT that in turn controls cell cycle 6786 84876 4609 PMC2981059__F6 HER/HER2-PI3K-Akt-NFKB-elicited pathway in prostate cancer cells 1950 367 5728 5970 PMC2981143__F1 Folate metabolism and its contributions to physiological processes 4524 4397 1719 10400 PMC2981398__F1 Role of the N-end rule pathway in RGS protein degradation 123803 11101 5996 26575 5997 6001 64407 8490 5999 85397 9628 6000 8786 5998 6003 PMC2990476__F3 Functional network identified by genes in the single nucleotide polymorphism (SNP) component using independent component analysis 117145 10723 113791 PMC2999593__F1 Heme Biosynthetic Pathway 210 7390 7389 130749 PMC3001886__F5 Coxiella burnetii, the Agent of Q Fever, Replicates within Trophoblasts and Induces a Unique Transcriptional Response 3572 351 6007 3598 7040 3458 3596 3565 133 6774 PMC3003620__F1 PI3K/Akt signaling pathway 7248 2475 6009 6194 PMC3004338__F4 Ingenuity Pathway Analysis (IPA) of differentially expressed genes between 24 DSS and 56 uncomplicated dengue patients 6404 5275 1992 5936 388324 6037 7035 6770 7008 12 3931 PMC3006290__F1 Proposed signaling scheme for ischemic preconditioning 2638 2932 367 PMC3010226__F2 Cellular and molecular scheme for an adaptive immune axis leading to acute lung disease after viral infection 5132 6363 1236 1234 2205 920 2826 7054 196 PMC3011892__F1 Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles 324 914 940 941 1493 942 923 920 3683 958 29851 214 10666 3689 5788 933 6693 PMC3017081__F4 Cell cycle G1/S check point subnetwork 115426 5325 4089 4088 60436 2885 3065 2932 545 993 472 1017 7157 25 1163 1869 898 1029 6502 7027 595 5925 8900 3429 1019 1026 1021 1030 1032 983 7040 4863 PMC3017463__F4 Schematic illustartion of microglial (A) and astrocytic (B) events taking place in the spinal cord in neuropathic pain 6376 6347 627 PMC3022188__F1 Rationale for dual treatment targeting the IGF-1R signaling pathway in RMS 3480 3667 2475 PMC3022256__F2 Patterning the DV axis in Drosophila and Tribolium 1950 6010 7039 PMC3024251__F6 Downregulation of miR-342 is associated with tamoxifen resistant breast tumors 5426 545 55120 PMC3025384__F2 JAK/STAT3 signaling pathway transmits information from cytokine/chemical signals outside the cell, through the cell membrane, and into the gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell 7099 4615 6774 7189 51701 2475 1499 PMC3025468__F11 Compartmentalization of TNF-R1 signalling and A-SMase activation 7124 8717 8772 637 1509 836 842 PMC3026729__F7 Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice 6910 2626 10021 8913 6909 650 6331 100188776 PMC3031466__F10 A PtdIns(3)P-mediated signaling pathway that drives the degradation of apoptotic cells 58533 6642 51699 PMC3036164__F8 Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis 1910 1906 1909 9464 PMC3042531__F3 Regulation of Innate Immunity by signaling pathways emerging from the endoplasmic reticulum 7099 22926 4615 114609 3569 7124 7494 468 PMC3044403__F1 The GlcNAc and GalNAc salvage and O-GlcNAc signaling pathways 55577 2585 2582 8473 10724 PMC3049335__F1 The Nrf2 pathway in PD pathogenesis 9817 4094 1728 57716 7019 PMC3049838__F3 Wnt signaling pathway activation in R1A deficient tumor cells 324 2932 1499 4041 PMC3051261__F11 Schematic Models of Tap46/Tap42/A4 Functions in TOR Signaling Pathways in Eukaryotes.(A) TOR signaling in yeast 4881 2475 1977 6194 PMC305326__F1 The development, activation, and maintenance of the satellite cell 5081 3082 3479 6420 4617 PMC3058235__F1 Control of GnRH secretion by growth factors and small molecules produced by glial cells 7039 3479 7040 PMC3058357__F3 GRAIL and Otub1 regulation by the mTOR pathway controls naïve CD4 T cell proliferation 2475 940 3558 PMC3059259__F2 Autophagy, inflammation and neurodegenerative disease 7124 3553 3458 PMC3061549__F1 The classical and alternative selection pathways in the thymus 920 925 50943 PMC3061884__F7 100 frequent associations obtained after p value cut off in BLCA with CDCOCA 100506658 5533 5708 2339 4092 5062 PMC3064126__F6 PHEX, DMP1, matrix extracellular phosphoglycoprotein (MEPE), and ASARM peptides are proposed to dynamically regulate FGF23 expression in bone 8074 5251 1758 5212 PMC3069698__F1 The Fanconi Anemia and Breast Cancer Susceptibility Pathways 545 7398 55215 2177 675 PMC3069928__F1 Biological actions of IGF-1 are mediated by IGF-1R and modulated by IGFBPs 3486 3667 5163 3479 3481 PMC3070842__F1 Lessons on transcriptional control from the serum response network 2353 1958 10762 6722 3150 3458 PMC3070844__F3 Top-scoring network created by Ingenuity Pathway Analysis 10549 5518 871 4869 302 5055 2539 10525 6888 PMC3071831__F7 Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures 3480 3479 2313 5728 7249 7248 6009 2475 253260 PMC3073290__F1 Models of how IFNB and GA activate PI3KD/Akt and MEK/ERK pathways to induce sIL-1Ra production in monocytes 3454 3455 6772 PMC3077082__F4 Microbial manipulation of receptor crosstalk in innate immunity 961 7097 7096 5879 PMC3079059__F1 Control of intracellular heme levels: Heme transporters and Heme oxygenases 130749 7389 10058 2235 23456 22 PMC3081620__F1 Representative cascade of the TGFB pathway 4087 4089 7018 PMC3082324__F7 Serpinin formation, its signaling pathway, and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells 1081 107966124 6667 PMC3083967__F5 Key regulators of the mammalian target of rapamycin signaling pathway 6446 5728 2475 253260 7249 7248 PMC3089033__F8 Diagram of the proposed cell survival signaling pathway in ER+ breast cancer cells with PI3KCA mutations and low phosphorylated Akt 23678 5163 2314 572 2309 PMC3092098__F1 The genes and pathways associated with Crohn's disease pathogenesis 64170 345611 5966 283463 3385 3383 23308 3559 29851 6364 117289 7039 PMC3092277__F1 Hippo signaling network in mammals 154796 4771 4485 60485 166824 9113 26524 PMC3092522__F1 HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies 5728 2475 3480 PMC3092676__F4 Emerging molecular functions of RASSF8 999 1499 6714 1445 11228 PMC3095361__F9 ROS, elicitor and hormone regulation of O3-induced CRKs 4881 7018 373863 PMC3095770__F2 Hypothalamic proopiomelanocortin processing and the regulation of energy balance 5443 6774 4808 5126 1363 5547 PMC3095949__F3 Functional pathway analysis of the 28-gene prognostic signature using Ingenuity Pathway Analysis 3493 27346 4321 3339 2204 4071 22914 4500 7296 638 6286 3636 1147 2633 3326 3866 292 6241 1847 6667 29978 5702 2908 7157 10926 5395 1477 4436 2072 5893 7486 PMC3096054__F1 miRNA biogenesis pathways and regulatory networks 3178 192670 26523 27161 192669 PMC3097472__F1 Methionine, an essential amino acid required for protein synthesis, is the source of methyl groups for a number of methylation reactions such as methylation of nucleic acids, proteins, biogenic amines, phospholipids, and for creatine synthesis etc 4397 635 875 PMC3099728__F8 Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression 3479 5728 2308 860 PMC3100753__F4 Regulation of the estrogen signaling pathway inside the nucleus 27043 100187907 1488 PMC3104484__F5 Interplay between Wnt, Nurr1 and En1 signaling in vitro and in vivo 1499 474168 2019 PMC3109102__F1 Basic intracellular molecular pathways regulating MN survival during development 841 5728 2475 4193 842 317 836 PMC3109273__F1 Host cell death pathways targeted by L 6389 664 581 331 PMC3109492__F2 Intestinal Effector T Cells in Health and Disease 64806 85480 50943 PMC3110678__F3 SAT and PT domains of NSAS in aflatoxin B1biosynthetic pathway 1178 3073 3074 PMC3112527__F3 Summary of the signaling pathway mediated by RET 2886 2887 6714 55816 55715 85358 10818 2885 PMC3114309__F1 The NFAT structure 7018 6667 6668 6670 PMC3118279__F2 Ingenuity Pathway Analysis of epidermal genetic information retrieval-harvested melanoma specimens identifies overexpressed genes involved in melanocyte development and pigmentation 3815 2885 6714 1398 4286 6663 5077 596 PMC3121540__F4 A gene network shows that mRNA levels of PDGFR and ECM-related genes are significantly correlated in human breast cancer 6678 633 4060 4015 4313 1634 4237 2200 PMC3126106__F3 Chemosensory processing in the taste – reward pathway 8989 29850 5330 PMC3133912__F8 Bhlhb5 and the Notch signaling pathway 120237 121643 3955 6469 10215 PMC3135180__F3 Convergent stem cell regulatory networks control expression of key stem cell genes 51176 6657 79923 PMC3139800__F1 Regulation of endonuclease activity in human nucleotide excision repair 7507 7508 5111 51426 PMC3140475__F5 Proteomic Biomarkers for Acute Interstitial Lung Disease in Gefitinib-Treated Japanese Lung Cancer Patients 720 3273 721 325 718 3514 116362 5265 10347 462 345 3250 2934 3240 12 3043 3045 100187828 PMC3143377__F2 Molecular Targeted Approaches in Mantle Cell lymphoma 5728 2932 572 PMC3145576__F5 Pathway analysis of proteins detected at elevated concentrations during time course analysis in lung following intratracheal instillation of 20 μg carbon nanoparticles (CNP) 6367 3565 7124 3553 7450 2155 PMC3145614__F1 Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium 9415 3992 54898 PMC3146625__F1 Schematic overview of the steroidogenic pathway 23600 2194 6770 1583 3284 1646 6715 1586 7367 3293 8644 3294 3295 7366 1645 PMC3146784__F2 TLR ligands and signalling 7097 7100 7099 10333 114609 4615 7098 3661 51284 54106 3665 PMC3149740__F5 Mammals have two distinct but ultimately converging pathways to apoptosis 572 638 90427 8739 581 666 637 8717 8772 PMC3151103__F9 Schematic summary of a signaling pathway underlying IL-1Beta-induced dedifferentiation of primary cultured articular chondrocytes 3603 10135 23411 6662 PMC3151543__F2 Schematic depiction of how complement modulates T-cell immunity 324 958 941 942 920 940 718 596 355 PMC3155176__F4 FRAM Is Characterized by Increased Signaling of the BRAF/MEK/ERK Pathway(A) IPA analysis led to the generation of a gene-interaction network of genes differentially expressed in patients 6401 23002 8205 23671 83937 1844 953 673 PMC3159106__F3 TLRs crosstalk with the phosphoinositide 3-kinase (PI3K) signaling pathway 7097 7099 4615 7189 23118 257397 2475 PMC3159175__F1 Multiple TYRO3-activated pathways signaling pathways converge with transcription or activation of MITF (reproduced from Mitra et al ()), an oncogenic transcription factor often dysregulated in malignant melanoma 7301 6663 4286 5077 PMC3163125__F1 Complement system: the classical complement pathway involves a sequentially acting multistep cascade in which the complement components C1q, C1s, C1r, C4, C2, and C3 play important roles 721 727 730 729 735 PMC3163143__F2 Schematic presentation of molecular changes associated with N-Myc amplification in neuroblastoma 4149 4601 4193 4610 PMC3163765__F2 Signal Transducer and Activator of Transcription 5a/b: Biomarker and Therapeutic Target in Prostate and Breast Cancer 3717 6776 6777 367 PMC3163776__F3 IRE1Alpha-XBP1 pathway in glucose homeostasis 85451 7186 811 4189 PMC3163779__F1 Thyroid hormone action is modulated by the deiodinases 7200 6955 6957 PMC316759__F5 Regulation of reproductive growth and metabolism by the DAF-2 insulin receptor-like signaling pathway 3479 5266 5164 5163 208 207 PMC3170087__F2 dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity 7098 920 3458 PMC3170128__F5 Innate and adaptive immune responses to cell death 10628 847 114548 3146 PMC3170587__F2 Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma 1398 6714 3932 23624 1390 PMC3172101__F1 New additions to the Hippo pathway in flies (a) and man (b) 960 23558 154796 PMC3174148__F4 Predictive Power Estimation Algorithm (PPEA) - A New Algorithm to Reduce Overfitting for Genomic Biomarker Discovery 5994 3111 1267 3122 1960 7157 3275 1512 51393 2167 PMC3174390__F4 Inhibitory role of Smad7 in renal fibrosis and inflammation 3553 4092 4089 4088 4087 PMC3174756__F5 Ephrin and neurotrophin signaling pathways in primary neurons 4803 6955 107966124 PMC3174986__F3 Plasmodium falciparum-Infected Erythrocytes and IL-12/IL-18 Induce Diverse Transcriptomes in Human NK Cells: IFNA/B Pathway versus TREM Signaling 3458 6773 6772 8554 10379 3659 5696 3437 3434 3430 PMC3175541__F7 NK2 homeobox 1 (NKX2-1)–Sam Pointed Domain Ets-like Factor (SPDEF)–associated gene network analyzed using Ingenuity Pathway Analysis 5005 5004 3458 7080 8785 29851 886 4321 3679 1387 25803 374 7094 85477 10551 1179 PMC3179275__F4a Integrative computational biology for cancer research 3725 4149 1399 PMC3183400__F4 New Insights into insulin resistance in the diabetic heart 3667 6774 9021 PMC3185509__F1 Activation of antiviral and proinflammatory responses during HSV infections 7097 4615 54106 7098 57506 3661 3665 79109 PMC3185527__F3 Illustration of the type I IFN signaling pathway and its inhibition by the henipavirus P, V and W proteins 3455 3454 3716 7297 6772 6773 PMC3188673__F5 Vitamin D Metabolism and Function in the Skin 22943 2932 324 595 PMC3190192__F1 PRL crosstalk with estrogen, progesterone, EGF/TGFA, and IGF-I 1950 5617 7039 PMC3190890__F7 The signaling pathway of EpCAM complex proteins in the regulation and enhancement of OSKM-mediated pluripotency reprogramming 4072 1366 5664 6868 6657 PMC3192435__F2 Targeting the PI3K/Akt/mTOR pathway to treat lymphoma 7249 7248 6009 PMC3192752__F5 Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment 1581 1582 570 PMC3193228__F5 Possible mechanisms of involvement of nuclear receptor LRH-1 in development of pancreatic cancer 1499 847 79923 PMC3198803__F7 CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae 1314 51083 5805 6908 PMC3198893__F4 One of the networks of genes commonly induced in both dendritic cells and macrophages when infected by bacteria, in both human and mouse 5782 4082 8714 5359 1316 PMC3204848__F13 Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane 5336 367 4512 PMC3205325__F2 Canonical TGFB signaling; Smad-dependent pathway downstream of TGFB receptors 7939 4087 4088 4089 PMC3205852__F10 Schematic illustrating the potential role of integrin B3 (ITGB3) in ROS-induced migration and invasion of colorectal cancer cells 6714 2885 6647 3925 PMC3207123__F1 A view of CD133 expression as it relates to variety of normal tissue and cancer stem cells 406983 2475 3091 7852 PMC3213224__F3 Possible mechanism of reciprocal enhancement between innate and adaptive immunity, through NF-kB and STAT-1/IRF-1 pathway 6352 6772 4283 3627 2833 1234 PMC3213765__F13 The sonic hedgehog signaling pathway in the primary cilium 6469 6608 51684 595 894 PMC3215943__F3 MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY 1958 23237 627 2475 PMC3215943__F4 MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY 23237 1958 266743 2475 PMC321618__F7 Statins and bacterial infection: model illustrating the effects of statins on S. enterica serovar Typhimurium infection 5340 6010 7054 PMC3218875__F2 Noncanonical NFKB signalling 958 4055 7185 7186 7187 5971 PMC3221684__F8 Insulin Receptor-Mediated Signaling via Phospholipase CG Regulates Growth and Differentiation in Drosophila 1956 126669 6010 6770 PMC3221733__F3 Drosophila melanogaster as a model system for human brain cancers 1956 253260 4609 1977 1019 1017 PMC3225948__F7 Three arms of the unfolded protein response stress-responsive signaling pathway 7494 22926 468 1998 PMC3226388__F3 Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway 7248 7249 6009 2475 27250 29904 6194 1977 1975 PMC3231999__F1 Immune evasion strategies of Porphyromonas gingivalis 727 7852 7097 7096 5879 2932 PMC3233287__F2 Illustration of main mechanisms of trastuzumab resistance (in red) and targeted agents to circumvent resistance (in blue) 2885 5728 5290 3480 7249 7248 PMC3233626__F5 NIRF interaction network 1021 1019 3065 6872 6908 1017 5111 9014 3621 983 PMC3237253__F3 Adhesion of sickle red blood cells to the endothelium and cell activation 960 4059 948 7412 961 PMC3239234__F3 Various signaling pathways modulated by the primary cilium 4040 4041 1499 6469 6608 PMC3241422__F10 Control of Rho1 activity through the cell cycle 11043 6094 116844 PMC3241422__F8 Mpk1-driven FKS2 transcription 11043 6094 780905 PMC3244200__F4 Epithelial–mesenchymal transition (EMT)-related pathways 1950 6469 2353 3725 999 1956 PMC3245021__F3 Reformatted modeling of the BioCarta ‘apoptotic signaling in response to DNA damage’ pathway 596 598 581 637 54205 317 572 472 207 7157 PMC3246665__F6 Diagram of signalling pathways indicating the possible mechanism by which sildenafil reverses the memory deficits in aged transgenic Tg2576 mice 1020 627 23237 PMC3248179__F2 Evi1 forms a bridge between the epigenetic machinery and signaling pathways 5728 7249 5164 6009 PMC3248218__F3 NUAK2: an emerging acral melanoma oncogene 81788 7249 7248 6009 2475 PMC3251651__F4 Novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy 4193 25 10006 7157 25942 6839 1719 5111 PMC3252731__F1 TLR4 signaling pathway is highly regulated 7099 4615 51135 3654 29110 7189 3661 6761 PMC3253327__F1 Acute and Chronic Regulation of Aldosterone Production 1583 6770 1585 3284 1584 PMC3260807__F1 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health 5728 7249 7248 6009 2475 6194 1977 PMC3260807__F4 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health 472 4193 780 5728 673 5163 23152 1499 PMC3263550__F2 Parkinson's disease pathway from the KEGG disease database 1565 7054 6622 6804 7317 9627 2861 5728 PMC3266027__F1 Activation of EGFR signaling in non-small-cell lung cancer (NSCLC) can occur via disruption of several different components at multiple levels of the pathway 7039 1950 5728 572 3845 PMC3266776__F2 Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma 983 1869 1870 317 6502 PMC3269021__F8 Interaction of TOR pathway members for the regulation of phagocytosis 5164 5163 5728 7249 6009 PMC3270467__F1 Putative galanin-mediated neuronal pro- and antinociceptive mechanisms in the dorsal horn of the spinal cord 8811 7442 51083 2587 PMC3272142__F4 Signaling pathways promoting trophoblast invasion and migration 2932 1499 2475 6010 PMC3272176__F1 Signal Transduction pathways downstream of activated HER family of receptors 5728 2475 595 PMC3274489__F1 Overview of the mevalonate pathway 717 4553 729 727 PMC3276354__F1 Canonical Wnt (Wnt/Beta-catenin) signaling pathway (adapted from Ref 50964 2932 6009 324 1499 2475 7008 4040 4041 PMC3280275__F6 Kinome-Wide Functional Genomics Screen Reveals a Novel Mechanism of TNFAlpha-Induced Nuclear Accumulation of the HIF-1A Transcription Factor in Cancer Cells 54822 28951 90956 3091 PMC3281571__F1 Simplified view of the mTOR pathway 3667 7249 7248 6009 2475 64223 1977 PMC3285038__F2 Schematic summarizing the role of signaling Smads in epithelial carcinogenesis 4087 4088 4089 5728 3082 999 PMC3285217__F1 Drosophila signaling pathways that regulate humoral responses 1611 8772 4615 23118 PMC3285398__F2 Proposed mechanisms of interaction between TLRs and MUCs: I 2064 1499 2932 51135 7189 PMC3285553__F4 Schematic illustrating numerous small molecules and biological compounds identified in the literature that inhibit Wnt/Beta-catenin signaling at various points in the pathway 27122 8324 6424 8325 2932 1499 324 PMC3291999__F3 MTOR signalling pathway (see text for details) 3667 5728 5163 7249 7248 6009 1977 PMC3292309__F3 Activation of inflammatory mediators in pancreatic Beta-cells in type 1 diabetes 3606 8717 4615 7186 6772 PMC3293571__F7 EMT downstream of TGFB and HMGA2 8091 9839 6935 PMC3294197__F3 Ingenuity Pathway Analysis of genes that are differentially methylated (P<1.8 × 10−6) between normal mucosa of cancer patients and controls 4151 26191 3558 1950 9146 290 901 83878 3172 29946 56257 PMC3294429__F4 The NDT80 transcriptional induction pathway 983 8317 101180900 PMC3295063__F2 NFKB in Aging and Disease 8772 4615 7535 7186 8717 3932 49 8915 7189 472 PMC3296187__F1 Schematic representation of the RKIP signaling pathway and its effects on metastatic progression to the bone 4312 571 7852 8091 PMC3298638__F2 Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs 4040 4041 6608 1499 9794 607 PMC3298733__F1 New therapies targeting the deregulated pathways to treat TICs in pancreatic cancer 100133941 960 4851 PMC3302445__F7 How BRG1 and CHD4 antagonistically influence Wnt signaling during yolk sac vascular development 1499 1108 6932 PMC3309773__F7 The functional role of Akt1, EMSY, and BRCA2 in the regulation of ISGs 3454 3455 7297 3716 6773 10379 56946 675 PMC3309773__F1 Regulation of ISGs by Akt1 and EMSY 207 10379 6772 6773 56946 9636 8519 PMC3309874__F1 Insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) is a major candidate pathway in human longevity 3630 3479 3667 3480 3643 PMC3309942__F2 p62 in osteoclast signaling and protein trafficking 7189 1540 5163 23118 PMC3310792__F8 Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells 7038 355 5091 PMC3313983__F5 Associations between HIV and Human Pathways Revealed by Protein-Protein Interactions and Correlated Gene Expression Profiles 7039 1950 1956 6774 3716 6772 PMC3314429__F2 miRNA-mediated immune regulation and immunotherapeutic potential in glioblastoma 6774 5728 1956 PMC3320915__F7 Model of proposed CCR7/CCL19 signaling pathway in T cells 1236 6363 10365 PMC3321615__F1 Canonical and noncanonical pathways of NFKB activation 929 7099 958 5971 PMC3324133__F1 Insulin receptor (INSR) belongs to a family of receptor tyrosine kinases that includes the receptor for insulin-like growth factor 1 (IGF-1R) 3481 3643 6774 10645 572 2475 1977 PMC3325226__F3 A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study 3606 7099 1356 54658 3146 5970 10891 4609 196 PMC3328908__F10 Diagram of canonical actin cytoskeleton signaling pathway 1950 1398 1611 324 2934 100187761 PMC3331705__F1 Tumor suppressors and oncogenes in the Wnt pathway 64840 10010 324 607 4040 4041 PMC3334407__F5 Schematic model for inhibition of cell proliferation by EGCG analogs 7249 7248 2475 PMC3339861__F3 EGF decreases sphingolipid biosynthesis transcripts 55304 1950 8879 2531 8877 130367 123099 427 125981 8560 7357 55512 166929 79152 PMC3342049__F2 Autophagy within antigen donor cells and cross-priming 324 325 7098 6850 PMC3346698__F5 The main chain path of pheromone response pathway (b) the assembly paths detected by Scott et al 998 84188 48 PMC3346698__F8 One of the KEGG prostate cancer pathways (b) the paths detected by our method 596 1956 999 5829 5163 11140 3660 6670 7157 PMC3348393__F1 Cellular Senescence and Cancer Chemotherapy Resistance 545 472 672 3014 9656 PMC3348440__F1 Target-derived NGF mediates axon growth and synapse assembly in sympathetic neurons via endocytic signaling mechanisms 6722 1960 4803 PMC3351343__F6 Working model for onset of emphysema in Fut8+/− mice upon exposure to CS 4092 4087 7018 2530 PMC3355926__F1 Activation of the Pi3K/Tor pathway by insulin and glutamate 5728 7248 7249 4763 2332 PMC3356623__F6 Influence of Tc-axin and Tc-pangolin on canonical Wnt signaling and role of Wnt signaling in axis formation in the bilateria 474168 324 1499 PMC3358876__F1 H. pylori-induced miR-155 expression in macrophage immune cells 4615 23175 5366 81619 7097 7096 10333 7099 PMC3361581__F1 Depiction of arachidonic acid signaling pathway highlighting genes measured in this study 5742 5743 240 239 246 5737 5733 5732 5731 5734 5739 5729 PMC3362995__F5 The WNT10b and galanin-mediated signaling pathways linked to adipogenesis 6425 27123 1869 4023 PMC3364790__F4 Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells 1356 6887 2244 4046 1896 26298 PMC3365794__F2 Model showing arterial, venous, and lymphatic cell fate specification in the developing embryos 54345 182 5629 100188776 2050 8828 PMC3365812__F1 Wnt/Beta-Catenin signaling pathway and their inhibitors 999 4040 4041 2932 324 607 4609 PMC3365861__F6 Opposing roles of Myd88 and RAGE in extensive liver resection 4615 2739 6774 5292 PMC3368734__F7 Functional interaction network analysis of genes with enriched expression (EE) and differential splicing (DS) in the placenta 2033 6670 7157 6667 2353 1437 5209 10370 133 2625 3726 2624 768 10912 4773 PMC3372530__F2 Diagram of genes that have been implicated in susceptibility to CL and ML disease caused by L 3569 7048 7046 3570 4088 4092 4087 6774 4089 6667 2313 1278 PMC3374768__F11 Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury 2064 1956 1950 PMC3375870__F1 miR-23a, a critical regulator of “migR”ation and metastasis in colorectal cancer 55294 9788 4609 388 6714 3725 5879 388585 PMC3375988__F7 Schematic representation of the proposed roles of oleosin 5091 4099 4018 PMC3380573__F1 Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment 3479 3667 2475 7249 6009 64798 1975 PMC3381650__F3 Signaling Networks of the Herpesvirus Entry Mediator (TNFRSF14) in Immune Regulation 324 2885 151888 11126 PMC3382204__F6 Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease 914 952 960 924 920 947 930 933 100133941 928 951 3562 7124 929 945 2057 2056 948 7173 367 3558 958 PMC3382968__F1 The four principal manifestations of immunological autophagy 7189 920 114548 9447 PMC3384423__F4 CRLs/SCF E3 ubiquitin ligases regulate mTOR pathway 7428 8453 9820 8451 8454 7249 7248 23239 2475 27250 9978 PMC3384424__F1 The mTOR signaling pathway 64798 6009 55615 9776 27250 PMC3385949__F1 FOXO proteins are involved in multiple signaling pathways that control cell proliferation, apoptosis, survival, and immune functions in response to external and internal stimuli 3562 3479 4803 2322 1950 4193 4485 1499 1956 PMC3386597__F4 AhR-related signaling molecules are enriched within the AML Signalisome 196 8728 4094 8850 2113 4313 84733 953 10769 1789 1912 6095 3213 481 64919 1021 PMC3389182__F1 Transcriptome analysis of HeLa cells response to Brucella melitensis infection: A molecular approach to understand the role of the mucosal epithelium in the onset of the Brucella pathogenesis 5566 5567 4149 1649 5924 10235 2002 2005 4139 8986 1616 10912 1647 7786 3725 1832 836 6789 1398 6416 4294 8491 8517 1147 11072 1956 4914 5322 7534 673 5604 2885 6655 11069 4342 57787 4609 4137 PMC3392049__F3 An example pathway 2950 367 5728 4193 51176 596 5925 1869 PMC3392647__F3 Metabolic regulation of epigenetics 23411 51548 8473 PMC3393470__F1 Chemical structures of PSI-352938 and its potential metabolites and the proposed metabolic pathway of PSI-352938 activation 1576 2987 100 PMC3394505__F9 Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas 5727 324 2735 PMC3395153__F1 Roles of Platelets and the Signal Transductions Identified as the Major Cascades in Hepatocyte Proliferation 3569 3082 3479 7039 6774 2475 PMC3395995__F1 Alloantigen presentation via the direct, semi-direct and indirect pathways following organ transplantation, and (B) the relative intensity of each antigen-presentation pathway during the post-transplantation (post-Tx) period 920 324 5966 PMC3401455__F2 Rad51 filament formation and regulation 5893 118027463 5888 5111 PMC3401939__F1 Targeting of oncogenes and miRNAs by retroviruses 6714 4602 4342 2353 4609 5292 3932 PMC3405333__F9 Pathway component for cell cycle G2/M DNA damage checkpoint regulation 23237 672 914 PMC3407412__F3 Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles 324 914 941 940 942 1493 7054 920 3683 3689 958 29851 214 923 10666 933 5788 6693 PMC3407412__F5 Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles 387 7408 3611 5728 126669 572 PMC3408825__F1 Autophagy pathway: signaling systems and three proposed membrane sources in autophagosome formation 114548 3553 3146 9447 PMC3411424__F3 Binary-relation notation and key molecules of AlzPathway 4137 351 1499 4804 7099 7076 3569 348 2475 PMC3412266__F1 Atypical PKC signaling pathways leading to lymphocyte activation and/or differentiation 613 3566 10892 7189 5970 6778 4772 PMC3412960__F4 Scheme of the Rho signaling canonical pathway identified in Ingenuity Pathway Analysis of the proteins with altered expression in both KO cell lines 4018 3479 2041 3480 9826 396 9181 397 6242 54443 5091 5962 4478 7430 PMC3418637__F1 Context-dependent effect of PI3K signaling on Treg development, differentiation and maintenance 108348016 50943 940 PMC3420937__F6 PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development 1956 3643 2885 5728 207 PMC3422654__F1 Genes Associated with Outcomes in the Context of Two Fatty Acid Metabolism Pathways 28965 2181 2180 23417 56894 PMC3423122__F10 Transcriptome of genes encoding enzymes and proteins on the lactose synthesis pathway, including GLUT1, HK1, PGM1, UGP2, GALE, GALT, SLC35A2, LALBA, and B4-GALT1, -3, and -5 3098 3906 5236 7360 2683 2592 2582 8703 7355 PMC3423122__F11 Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans 5618 3717 6774 6772 7360 1051 6667 7355 2056 3659 PMC3425856__F4 CO prevents inflammatory responses via inhibition of NFKB signaling pathway 4615 3383 7412 PMC3425953__F2 The activity of the EGFR/KRAS signaling pathway in normal and tumor cells 1956 3845 673 PMC3426114__F9 Two Possible Models Regarding the Role of CDT1 Proteins in Response to DNA Stress.(A) Downregulation of CDT1 upon DNA stress may be promoted by WEE1 and/or SOG1 81620 545 472 7465 PMC3431883__F3 Signaling mechanisms of oligodendrocyte injury 355 8772 6772 PMC3432564__F2 Transmembrane CLRs involved in antifungal immunity and their intracellular signaling pathways 6850 4615 5894 64170 10892 PMC3433920__F4 Acute phase canonical pathway and corresponding acute phase reactants identified as significant for interaction effect 6774 2475 1401 2243 718 3929 12 629 350 7276 197 335 5267 710 1356 325 3053 462 735 3273 PMC3435197__F2 Spectrum of somatic mitochondrial mutations in five cancers 4519 3418 3417 PMC3435478__F2 Age-related alterations in receptors and signaling molecules of CD8 T cells 940 3575 939 1445 9021 PMC3436147__F8 Putative mechanisms of the effect of the Kv1 4155 920 27040 3932 7535 8915 3738 50943 1236 PMC3437205__F3 Pathway analysis of the hypermethylated genes in lymph node metastasis including their biological processes and association to breast carcinogenesis and neoplasm metastasis 324 654 672 1029 PMC3439965__F3 Simplified overview of the canonical Wnt signaling pathway 2487 22943 324 PMC3443126__F7 H2O2-modulated permeability increase and cytoskeleton reorganization via MARCKS phosphorylation in endothelial cells 4082 5879 5335 25 10006 PMC3443885__F3 Molecular interaction between estrogen and thyroid hormone 6714 207 6772 PMC3457779__F1 The MAPK cascade activation and potential cross talk signals 2534 2885 8772 572 3725 596 581 PMC3461086__F3 Canonical Wnt signaling pathway 324 1499 2932 4040 4041 PMC3464875__F7 Signaling involved in MUC4 expression upon Nicotine, IFNG and Retinoic acid stimulation 6774 6772 1869 PMC3481284__F8 Schematic diagram of CaMKII regulates Notch1 signaling through proteasomal degradation of SMRT 7474 4851 3280 23462 388585 PMC3485057__F4 Increased Biomass Yield of Lactococcus lactis by Reduced Overconsumption of Amino Acids and Increased Catalytic Activities of Enzymes 9049 1636 100034700 PMC3488108__F1 Immune-Neuroendocrine Integration at the Adrenal Gland: Cytokine Control of the Adrenomedullary Transcriptome 3458 6773 6774 PMC3492703__F1 Biosynthesis and posttranscriptional processing of miRNA 54487 29102 23405 PMC3494587__F12 Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes 440275 8678 596 5599 1965 5266 468 7494 9695 9140 PMC3495983__F6 Model illustrating CD40-induced signals that mediate the expression of VEGF in endothelial cells 958 2475 64223 253260 PMC3496019__F1 Cancer Stem Cells 3549 50846 6469 91653 5727 6608 51684 11127 2736 2737 2735 4609 PMC3500394__F1 FoxM1 and WntBeta-catenin Signaling in Glioma Stem Cells 324 2305 1499 595 6925 4040 4041 PMC3502714__F3 Fibroblast growth factor 23: State of the field and future directions 8074 5045 2591 2264 PMC3503557__F5 Network and pathway structure for biologically informative priors in the cancer drug response data study 2064 5163 6464 6714 207 2475 572 672 983 1017 1385 PMC3506510__F2 Signaling pathways impinging on autophagy 5728 2475 253260 7248 7249 6009 PMC3508196__F1 TARGETING ONCOGENIC BRAF IN HUMAN CANCER 2064 1956 3815 4763 5728 2475 2353 4609 PMC3512188__F3 Roles of miRNAs in DNA damage response 7157 3014 693122 472 23411 998 8493 4193 PMC3524155__F1 Sensing the enemy 10392 64127 406947 PMC3524627__F8 Model depicting the regulation of DNA damage-induced germ cell apoptosis by C 207 5163 208 6446 PMC3525581__F7 Toxicogenomic Analysis Suggests Chemical-Induced Sexual Dimorphism in the Expression of Metabolic Genes in Zebrafish Liver 140805 100187761 2006 10763 PMC3527239__F5 Compartmentalization of the Beta-oxidation pathway and the glyoxylate cycle 4191 25913 48 PMC3528293__F1 Generalized overview of the extrinsic and intrinsic apoptosis pathways 7124 8772 637 8717 581 PMC3535856__F6 Proposed mechanism for MCME-mediated inhibition against migration of CL1 cells 7472 6714 1499 PMC3536147__F3 Identification of Burkholderia cenocepacia Strain H111 Virulence Factors Using Nonmammalian Infection Hosts 7808 5814 5813 PMC3538326__F7 Proposed mechanisms of the reduced activation of G3139 in RIT-INPs 54106 3569 958 941 942 596 4170 PMC3539134__F2 Inhibition of insulin signaling pathway by SOCS1 and SOCS3 3667 8660 9021 8651 5163 PMC3541025__F1 Autoinflammatory Disease Reloaded: A Clinical Perspective 9051 114548 5879 3554 PMC3541304__F1 Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis 1026 3091 64798 54541 7249 7248 2475 PMC3546058__F1 DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the omega-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways 351 5465 5468 19 629 250 3075 PMC3547956__F6 Transcriptional and Gene Regulatory Network of Lactococcus lactis MG1363 during Growth in Milk 132 5970 3258 5814 8473 PMC3548018__F2 Integrated scheme for MIF expression, signal transduction and regulation of glucocorticoid immunosuppression and cell survival 7124 4282 972 960 3579 7852 6714 9261 PMC3548172__F3 Cooperation of esBAF and PRC2 during pluripotency maintenance 3976 6774 6657 79923 PMC3552883__F8 Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells 5594 5595 8678 9474 9451 4170 PMC3555197__F1 LXRs and prostate physiology: potential beneficial actions of LXRs over prostate cancer 9619 19 64241 64240 3949 572 PMC3555518__F1 Mechanism of miRNA expression and/or function perturbation 29102 54487 2521 1655 10521 PMC3557298__F4 mRNA-seq Analysis of the Gossypium arboreum transcriptome Reveals Tissue Selective Signaling in Response to Water Stress during Seedling Stage 108348016 7018 1879 64641 578 51411 4881 PMC3557440__F4 Schematic overview of the homologous recombination (HR) pathway 10111 4361 5888 PMC3562241__F6 Ihh and Runx2/Runx3 Signaling Interact to Coordinate Early Chondrogenesis: A Mouse Model 100188864 3549 5727 6608 860 864 PMC3563405__F1 represents the melanin synthesis in human, plants, fungi and bacteria starting from tyrosine whereas; (B & C) shows melanogenesis from secondary metabolites in fungi and bacteria respectively 1638 7306 6319 PMC3565214__F1 Major oncogenic signaling pathway alterations in urothelial carcinoma 2261 5728 7248 7249 2475 PMC3566011__F8 HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion 1956 5045 10013 4088 PMC3573097__F7 Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma 1956 55781 83732 PMC3575845__F7 Anti-quiescence network mediated by the Myc-miR-22 pathway 3663 3146 4609 79800 10608 94241 PMC3577635__F2 Biochemical pathways leading to resistance to small-molecule epidermal growth factor receptor (EGFR)-targeting drugs such as gefitinib and erlotinib in non-small-cell lung cancer (NSCLC) 2621 558 1956 5290 5163 PMC3578923__F8 Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components 7873 34 5009 1629 1738 435 5095 3712 266710 593 PMC3580961__F2 Transcription at damaged DNA 7508 57654 7507 5111 PMC3582273__F1 CluePedia analysis example using expression data from human normal colon mucosa and colorectal tumors and in silico information 29851 3458 8174 940 6376 7412 29126 6772 80380 7341 5770 8554 5781 3717 5777 3716 3460 3459 9021 646981 5771 8651 5146 51056 8707 27020 3605 1558 PMC3585121__F6 Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci 100653366 2638 5617 27040 PMC3586749__F4 Epithelial to Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma 4087 4088 4318 2113 1950 1956 1829 999 PMC3594545__F1 Regulation of NFKB by Ubiquitination 3553 7189 81858 257397 23118 PMC3594545__F2 Regulation of NFKB by Ubiquitination 7706 57506 29110 10010 3661 PMC3595301__F3 Crosstalk between Wnt and local inflammatory signaling pathways for the control of SVZ niche homeostasis 7471 2932 1499 PMC3596326__F4 Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism 7808 847 81693 PMC3602989__F2 Leptin and cancer: Pathogenesis and modulation 3953 200186 6794 1588 PMC3605582__F1 Key mediators of innate and adaptive immunity, development, and signalling 10113 920 7096 7097 7099 10333 7100 54106 7098 51284 51135 3654 7189 7187 4615 3661 3665 3592 3593 3594 3595 149233 51561 3105 3106 4049 4050 7124 720 717 3717 7297 6774 6775 PMC3605881__F6 Scheme of mechanisms underlying attenuation of cardiac dysfunction induced by endotoxin, after NG-R1 treatment 7099 4615 7189 PMC3608394__F7 Enriched pathways and GO functional annotations are: (a) NFKB signaling pathway p=7.03e-05 57338 3551 7323 818 4790 8928 4089 4088 10401 10140 2932 23054 4793 367 4855 51773 1387 1051 5575 7329 PMC3612391__F2 Role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development 9723 57381 6395 PMC3612647__F1 A lithium-sensitive family of small-molecule phosphatases and the sulfate assimilation pathway 2203 10380 9060 PMC3616489__F3 Emerging roles of E2Fs in cancer: an exit from cell cycle control 1874 1875 1019 1021 PMC3617401__F2 Emerging actions of the nuclear receptor LRH-1 in the gut 1499 898 6925 595 PMC3621649__F1 Targeted therapy pathways.Notes: Protein kinase B (AKT) is a serine/threonine-specific protein kinase that affects glucose metabolism, apoptosis, cell proliferation, transcription and cell migration 6773 6772 6774 2475 PMC3623009__F1 Simplified scheme of the complement activation network 1356 717 718 721 727 2271 1380 1191 4179 1604 966 PMC3623797__F7 Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells 3454 114548 7098 57506 7706 3553 PMC3627223__F1 The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway 613 6850 4791 PMC3634910__F3 Nutrient Signaling to mTOR and Cell Growth 7249 51256 7248 6009 PMC3635523__F7 Schematic model put forward the potential role of P4HB at different GBM cell states to TMZ treatment 5034 22926 83939 468 581 PMC3636692__F3 The VEGF-DLL4-Notch signaling pathway in angiogenic sprouts 8829 182 8828 PMC3640280__F5 A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance 3479 2475 727 95 718 PMC3641099__F1 Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer 1362 54472 5600 PMC3643575__F4 Arachidonic acid metabolism pathway where the differential genes and metabolites of colorectal cancer were annotated 3976 4015 5225 65057 5228 1733 PMC3652812__F4 Thymidylate Synthase Expression Determines Pemetrexed Targets and Resistance Development in Tumour Cells 1719 2475 581 PMC3653431__F2 Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation 654 148738 3716 3717 6774 4090 4086 100188857 4089 PMC3654375__F3 Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning 6461 5879 387 PMC3656649__F1 ENDOCRINE RESISTANCE IN BREAST CANCER 1956 6714 6667 PMC3658307__F2 Liver Ischemia and Reperfusion Injury: New Insights Into Mechanisms of Innate – Adaptive Immune-Mediated Tissue Inflammation 958 6775 2833 54106 7099 3553 6347 3627 3576 3146 912 PMC3660182__F1 Glia-mediated detrimental and beneficial inflammatory pathways in PD 4353 8321 6651 PMC3660182__F4 Crosstalk between inflammatory and Wnt/Beta-catenin signaling pathways in MPTP-induced SVZ plasticity 7471 1950 2932 1499 PMC3660516__F4 Statins Are Associated with Reduced Risk of Esophageal Cancer, Particularly in Patients with Barrett’s Esophagus: A Systematic Review and Meta-Analysis 5879 6010 207 5266 PMC3663521__F7 Schematic diagram illustrates the role of Dapper3 in UUO-induced renal fibrosis by regulating Wnt/Beta-catenin signaling 4040 4041 1611 1499 595 8313 4316 PMC3663908__F1 Major signaling pathways leading to cellular apoptosis 8772 581 637 572 27429 PMC3666883__F11 Sonic hedgehog-Dependent Induction of MicroRNA 31 and MicroRNA 150 Regulates Mycobacterium bovis BCG-Driven Toll-Like Receptor 2 Signaling 4615 27148 2735 2736 51684 6469 6608 5727 7186 7187 7185 PMC3670291__F2 Roles of STATs signaling in cardiovascular diseases 2885 6714 6774 3716 PMC3670316__F7 Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis 89780 145873 6911 134701 PMC3671248__F7 Model for 20E regulation of IMD innate immune signalling 8772 23118 1805 PMC3671705__F1 Targeted therapies for head and neck cancer 1956 3480 2475 PMC3676795__F2 Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis 8772 5728 494324 5163 572 637 665 581 331 PMC3678733__F1 Human Hippo signaling pathway 261734 7531 7529 1856 154796 PMC3681701__F9 Sources of sphingolipids for the parasite 6611 1674 51552 27314 339122 PMC3683875__F1 Nucleotide excision repair (NER) pathway 1362 7508 7507 5111 2067 PMC3683896__F2 Extrinsic and intrinsic pathways of apoptosis 637 8772 317 PMC3686839__F2 Molecular Pathways: Extracting Medical Knowledge from High Throughput Genomic Data 4214 6416 1432 5599 5728 4792 5295 3725 5290 207 930 4609 PMC3689245__F7 Proposed mechanism for MTX-induced melanosome transport in melanoma 208 51451 5163 5873 PMC3690850__F7 Working model for rotavirus cell entry 81 998 387 8411 PMC3693108__F1 Therapeutic molecular targets for endometrial cancer 1956 2263 2475 5728 PMC3693544__F1 Transcriptional feedback in the insulin signalling pathway modulates ageing 6464 9798 5163 6446 207 208 6194 5469 6649 PMC3695632__F3 Case 19-2010: A 35-Year-Old Man with Adenocarcinoma of the Cecum 1956 2885 5163 253260 2475 4193 4609 595 572 4170 PMC3696647__F7 Schematic diagram for HIF-1A functions in cap-dependent translation of selective mRNAs, cell proliferation, and tumorsphere growth of cancer cells in low O2 environment 7249 7248 6009 9470 2475 317649 5936 1981 PMC3697894__F1 Notch signaling pathway 55851 28514 54567 10683 1950 PMC3697962__F2 Insulin-like signaling pathway 828 3643 407043 5728 5163 207 208 PMC3697968__F5 Model of DAF-2/IGFR pathway regulation by DPY-21 9798 5163 208 207 PMC3700945__F5 Pathway detail for the IPN: Mucus Hypersecretion model.Notes: The Mucus Hypersecretion model contains signaling detail from four main pathways known to induce airway MUC5AC production 3596 6667 7124 PMC3701867__F1 Scheme depicting the interactive roles of interferon, Trim, and Socs molecules regulating the innate response in SjS-susceptible C57BL/6.NOD-Aec1Aec2 mice 3569 7099 3466 4118 8651 9021 7090 81603 7189 6772 6774 85363 25939 4938 3661 4939 2475 PMC3703418__F2 Cellular mechanisms of BBR in reverting dysfunction in NAFLD 3569 3643 5465 PMC3703460__F3 Signaling Pathways That Control mRNA Turnover 1950 2885 5300 PMC3703536__F1 Highlights of 10 years of immunology in Nature Reviews Immunology 7099 7097 54106 114609 4615 54472 7189 PMC3707302__F3 Immunological synapse: the gateway to the HIV reservoir 102 6868 8650 920 PMC3709783__F6 UV-induced cyclobutane dimers- structure (A) and repair by the Nucleotide Excision DNA Repair (NER) pathway (B) 7507 2072 2073 1643 7508 2067 PMC3710315__F2 Identification of STAT target genes in adipocytes 3976 5008 3458 5617 PMC3711381__F3 Htt affects ERK signaling in multiple ways 627 1950 3064 PMC3713775__F1 MicroRNA and Signal Transduction Pathways in Tumor Radiation Response 472 55922 2146 23512 PMC3714559__F1 Model for resolving transcription-blocking lesions 7874 57654 7507 PMC3715049__F1 Proteomic strategies for studying the mechanism of miRNA processing and miRNA-mediated translation repression 29102 6723 642658 PMC3715730__F3 Ingenuity pathway analysis (IPA) of Interferon Signaling Pathway of genes differentially expressed in the bronchial epithelial cells exposed to Alternaria alternata spores 3458 204 6772 6773 8554 10379 3659 3434 PMC3718675__F3 Axis of ageing: telomeres, p53 and mitochondria 3479 23411 2475 2242 PMC3720736__F2 Activation of Wnt/Beta-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients 324 1499 4040 4041 PMC3722917__F3 Naive CD8+ T cells differentiate into cytotoxic T lymphocytes (CTLs) on exposure to antigens 324 920 7054 7216 PMC3724517__F4 Pathway analysis of differentially expressed genes in RAF265 responding versus nonresponding tumors 4602 8301 2696 PMC3726753__F2 Morphoproteomic Profiling of the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Desmoplastic Small Round Cell Tumor (EWS/WT1), Ewing’s Sarcoma (EWS/FLI1) and Wilms’ Tumor(WT1) 1956 3480 2885 5728 7490 2313 7249 7248 6009 64223 2475 253260 PMC3726964__F3 Regulation of the EMT Pathway and Tec kinase signaling in Calu-6 compared to U1752 387 57154 4089 8091 2113 9839 3398 6935 2303 999 7099 355 2353 PMC3732559__F5 HMGB1 in Cancer: Good, Bad, or Both? 3315 3146 8408 PMC3735686__F1 Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma 3980 5111 7507 5426 1104 2067 PMC3736320__F1 Déjà vu: EGF receptors drive resistance to BRAF inhibitors 3082 3084 1950 3480 5159 995 5728 PMC3737462__F2 Accumulation of monocytes/macrophages in adipose tissue and liver, and activation in the tissues 3553 6778 7099 9314 PMC3738179__F2 Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling 6608 5727 2717 PMC3742039__F3 Gene expression in keratinocytes related to IL-1 signaling 3552 3569 5340 3976 1956 5781 PMC3742712__F2 Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection 58484 114548 9447 3553 PMC3745930__F5 Roles of hnRNPs in the impaired granulocytic differentiation of BCR/ABL transformed myeloid progenitor cells 613 2521 10682 PMC3750075__F1 ACK1/TNK2, a non-receptor tyrosine kinase (NRTK), represents a paradigm of tyrosine kinase signaling that appears to be addictive in cancer cells 1950 51741 367 2064 PMC3755473__F1 Plasma Cells For Hire: Prior Experience Required 60468 639 2475 PMC3757373__F1 Methionine metabolism in liver 7054 4397 100271694 635 4524 875 PMC3759367__F11 Signaling pathway and proposed sites of arsenite perturbation 1950 4851 4090 4086 4089 3848 1844 8456 3858 PMC3760013__F5 Core genes for cetuximab and PX‐866 susceptibility 1956 7157 2475 4609 595 3516 PMC3764601__F4 The meiotic recombination pathway in C 389058 6671 6670 80320 100131390 121340 6668 6667 221833 4361 10111 5888 51750 4439 4438 PMC3764819__F4 Enrichment of the Notch signaling pathway in glioma CSCs 6868 196403 1857 388585 23462 182 3714 2648 4851 4854 4855 9253 3516 1487 6774 PMC3765220__F4 Pathway Studio analysis of the differentially expressed proteins of extremely severe HFMD serum samples. Proteins identified in Table  were imported into PathwayAssist and an interaction map was created 8547 5959 51109 2006 6121 672 5950 335 5371 3848 3698 2335 325 7001 2 5159 3240 PMC3765447__F3 Signaling pathways involving EPCAM, proposed by Maetzel D et al 999 2274 1499 324 2932 4072 PMC3769702__F5 Pathway diagram of the CTLA4 signaling in cytotoxic T lymphocytes from the IPA 1493 941 942 920 940 27040 3932 5335 2885 6850 2534 3717 PMC3770492__F2 A new Vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential Toll-like receptor 2/protein kinase C, zeta transduction pathway 7097 3654 114609 5590 4615 7189 6774 2353 6364 PMC3773757__F6 Summary of the convergence of the E2–ERK and mTORC1 signaling pathways in regulating migration and invasion in LAM patient-derived cells 6009 1975 9839 6935 PMC3775241__F3 Regulation of hepatic hepcidin induction at the cellular level 659 3569 168667 4091 4092 148738 6774 164656 4089 3077 7036 PMC3777916__F3 Using Biological Pathway Data with Paxtools 5236 6120 22934 PMC3778395__F1 Plant tetrapyrrole biosynthetic pathway 210 3145 7390 7389 1371 5498 2235 57716 5447 PMC3782523__F1 Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses 941 942 940 8205 652070 PMC3786361__F1 Epidermal growth factor receptor family and targeted agents 7039 1839 1950 685 367 1956 PMC3787304__F1 Different phosphorylation sites on STAT3 mediate canonical and non-canonical functions of the Notch signaling pathway 388585 3280 390992 2670 6774 PMC3788328__F1 Calcium and calcium-permeable channels in the control of autophagy 84932 56302 55503 7442 79054 90550 7226 2475 51393 PMC3789189__F8 CVB3-induced the PI3K-Akt-mTOR-apoptosis signaling pathway 7249 7248 207 208 PMC3792586__F1 TNF signalling pathway 7124 8567 8717 7186 8772 PMC3794382__F1 Gene sets are not pathways 6418 7124 7186 929 355 1616 7189 10454 23118 51295 PMC3798821__F4 The valine degradation pathway from the differentially regulated genes in response to 3–7 days of mechanical overload 587 593 594 1629 1738 28999 549 1962 3030 3032 26275 11112 PMC3801060__F6 Model of p21-mediated restriction of HIV-1 and related lentiviruses in macrophages 1869 4550 6053 4549 6052 PMC3806061__F1 Diagrammatic representation of the hedgehog (Hh) signaling pathway 6608 596 64399 PMC3806315__F2 Serine, glycine and the one-carbon cycle: cancer metabolism in full circle 1719 2731 635 4524 875 PMC3809754__F1 Biogenesis and function of microRNAs 29102 54487 100188857 1233 9924 3692 PMC3812667__F1 Bcl-2 inhibition may act directly on tumor cells but may also target the nutrient supply to the tumor by disrupting the blood vessels that form around, and within, the tumor () 3579 2919 3576 PMC3813433__F1 Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management 2475 253260 717 PMC3816537__F3 Pathway based analysis of high ranking composite score genes reveals key signaling pathways associated with PDAC clinical progression 355 1956 3845 6714 867 8772 5786 2475 5728 55738 836 1676 1677 PMC3819010__F2 EBPR metabolic map inferred from the Accumulibacter clade IIA genome, adapted from ) 2821 545 5132 132 23531 PMC3819341__F1 Summary of therapeutic invention points in the myostatin signaling pathway 10272 238 4087 4088 4089 2475 PMC3820452__F2 Working model for the signaling mechanisms that mediate the cellular functions of TRPM7 in pancreatic adenocarcinoma 54822 1950 1956 55872 9021 6774 PMC3820452__F4 Working model for the proliferative, prosurvival, and migratory roles of TRPM8 in pancreatic adenocarcinoma cells 79054 1950 1956 790 PMC3822007__F1 New developments in the Induction and Antiviral Effectors of Type I Interferon 29110 3661 1499 7187 PMC3824408__F1 Unveiling the last missing link of the cardiolipin synthetic pathway in mitochondria 1040 116969 283871 9489 PMC3825489__F3 Cross talk between the coagulation and complement system 718 7018 10747 717 727 5340 PMC3825518__F1 From Evolution to Revolution: miRNAs as Pharmacological Targets for Modulating Cholesterol Efflux and Reverse Cholesterol Transport 19 9619 3931 10113 1071 3949 7038 PMC3828628__F1 IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK 3667 9021 6774 PMC3828651__F2 Molecular events associated with tumor suppressor gene product-induced senescence or apoptotic cell death of tissue-resident stem/progenitor cells during chronological aging 5728 4609 581 472 PMC3834158__F3 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats 19 9619 338 7038 1374 79071 3156 2194 949 3949 PMC3835203__F1 New mechanisms of NOD-like receptor-associated inflammasome activation 7124 7099 114548 79184 57506 8011 115362 PMC3835370__F1 Genomic Characterization of the Inherited Bone Marrow Failure Syndromes 83990 672 675 79728 2072 29089 7398 PMC3836193__F1 Role of apoptosis in colon cancer biology, therapy, and prevention 355 637 581 PMC3837137__F6 A diverse range of signaling pathways that can lead to persistent PKC activation to support cell migration 4018 1950 369 673 79899 117584 4609 PMC3841320__F4 Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells 131566 1847 639 2261 5328 23462 3909 7378 3458 8204 6364 2769 1958 3202 8848 2113 6422 7057 2114 PMC3844062__F2 Proposed pathway for NLRP3 inflammasome activation during viral respiratory tract infection 3553 114548 834 PMC3851681__F1 Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection 10148 3595 3594 149233 PMC3851989__F3 The fourth module identified by iMCMC in the GBM data and locations of the detected genes in known pathways 1103 6572 1956 4763 4193 PMC3856107__F3 Roles and signaling pathways of let-7 in hypoxia- and neural stem/progenitor cells (NSPCs)-induced angiogenesis 26523 4087 4088 PMC3858190__F9 Ingenuity pathway analysis of differences between LPS and LPS + SMD (300mg/kg) with regard to reproductive hormones 84844 51441 9859 113 2669 2697 64968 9249 8522 5208 26999 3099 5209 6480 80232 90843 7358 83743 2885 4641 10105 9744 7371 55210 26275 7360 PMC3859141__F1 Molecular Pathways: Sterols and receptor signaling in cancer 1956 3949 2475 22937 PMC3859915__F2 Signaling downstream IL-2/IL-15RB 3716 3718 2475 PMC3860870__F1 Apoptosis by HPV early proteins: A number of the interactions of viral oncoproteins with cellular proteins and their effects on apoptosis 355 7124 8772 PMC3863730__F6 Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma 7099 4615 3654 51135 7189 PMC3866156__F1 Proposed mechanisms of aspirin, the single nucleotide polymorphism rs6983267, and their interaction on the WNT/CTNNB1 pathway 4513 1499 324 2932 6934 595 4609 PMC3868461__F7 Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter 355 3382 4118 11113 PMC3868569__F1 TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans 5163 207 208 PMC3872233__F4 Toll-like receptor 4 signaling pathway in alcohol consumption 7099 4615 3654 51135 3661 PMC3873642__F1 A proposed model of the DNA-damage response pathway 9025 9656 472 3014 672 PMC3874419__F1 Signaling cross-talk at the various levels of EGFR/HER2 signaling pathways 1956 5594 5728 4193 2475 PMC3874419__F4 Cross-talk of EGFR/HER2 signaling with other pathways 1956 5728 2932 3280 1843 1499 PMC3875243__F1 Characterization of Negative Feedback Network Motifs in the TGFB Signaling Pathway 717 339855 11113 6476 PMC3877660__F1 An overview of EGFR and Wnt/Beta-catenin signaling 1956 367 1950 2069 7039 4759 4041 1398 2886 2885 867 2932 1499 324 5728 2475 5292 4092 51339 595 PMC3878307__F1 TMEFF2 AND SARDH COOPERATE TO MODULATE ONE CARBON METABOLISM AND INVASION OF PROSTATE CANCER CELLS 29958 27232 1757 23671 2731 PMC3880903__F8 Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human 1244 8714 10257 PMC3882431__F6 Schematic representation of the proposed pathway by which deficiency of FXR activates the STAT3 signaling pathway in the liver 3603 3717 9021 6774 PMC3882535__F3 Novel GPCR-based signaling mechanisms in ASM 23236 157 5999 PMC3882710__F8 The potential role of MuRF1 in atrophy induced gene expression pathways 4606 9759 4208 3939 2027 4656 1144 1146 80339 5295 2268 1278 1306 PMC3883721__F1 Phosphoinositide-3 kinase (PI3K) is a heterodimer consisting of p85 and p110 subunits 7248 2475 7249 PMC3886260__F2 Lck is a central node in the T cell receptor signaling pathway 920 3932 1445 940 PMC3887202__F1 De novo synthesis of steroids, oxysterols, and bile acids from cholesterol 1588 1584 1585 1586 6770 1583 706 1593 1582 9420 PMC3887921__F2 Regulation of autophagy by nutrient signals 55626 7249 7248 7405 6009 2475 9776 8408 60673 PMC3889478__F1 Comparison of in vivo (left) and in vitro (right) signaling support to the intestinal stem cell 7473 1950 7475 7484 7482 7474 PMC3891116__F2 Essential cell signaling pathways for prostate cancer (PCa) development and crosstalks between themThe interaction of circulating androgens (T/DHT) with AR is critical for PCa growth 1950 3479 5728 3091 6774 2308 3817 1652 2953 162514 4942 5831 367 3570 1956 PMC3892099__F8 Summary of parthenolide-induced signaling pathway in NSCLC cell lines 83939 468 1649 8795 5366 PMC3893124__F1 Current and Future Therapies for Hepatitis C Virus Infection 975 949 1956 3949 57762 PMC3893527__F4 Signal pathways involved in renal IRI 4615 581 3553 7097 7099 PMC3894494__F7 Proposed model of heme-induced stasis 7099 929 4615 114609 7450 7412 3383 PMC3894710__F2 Autophagy: A Crucial Moderator of Redox Balance, Inflammation, and Apoptosis in Lung Disease 22863 8408 2475 PMC3895844__F3 Dopamine-DARPP32 feedback in cAMP signalling is a significant canonical pathway in an olanzapine-treated hippocampus 23440 1390 847 PMC3899188__F1 Regulation of lysosome biogenesis and functions in osteoclasts 9474 79158 9842 7942 9545 29887 528 9066 1513 10312 28962 100187907 PMC3899875__F4 MiR-148b in the mTOR signalling pathway 2475 3667 5728 5163 253260 3091 1975 7248 7249 6009 1977 673 PMC3899934__F2 Farnesoid X receptor–Acting through bile acids to treat metabolic disorders 7038 4023 3949 255738 1581 1582 64241 64240 PMC3899953__F6 A model for the role of ATP-mediated interaction between Rtg2 and Mks1 in ATP homeostasis 54903 48 3417 3418 PMC3903702__F1 EZH2 takes the stage when BRCA1 loses 23512 8726 2146 672 100124700 10873 PMC3904234__F1 Interleukin-17 (IL-17) and IL-17 receptor family members and their biological roles 84818 55540 132014 7189 7186 7188 PMC3908416__F8 Panx3 signaling pathways inhibit osteoprogenitor cell proliferation and promote cell cycle exit 116337 4040 4041 2932 1499 PMC3912139__F6 GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes 2778 4583 4586 PMC3912738__F4 The cross-talks between the Notch and the IGF signaling 3667 5728 2475 3091 PMC3913210__F1 Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction 51684 374654 23432 2121 5727 91653 50937 6608 2735 PMC3913210__F2 Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction 79659 6608 2736 5727 55764 2737 51684 51668 79600 79867 5901 55212 6015 23432 200894 2121 132884 PMC3913495__F1 IL-6 exerts its pleiotropic activity by activation of gp130 through its binding to transmembrane or soluble IL-6 receptor 920 1401 6774 2885 PMC3914444__F2 Scheme of PI3K/PTEN/AKT signaling network activated by heterodimerization of HER2/HER3 receptors induced by heregulin (HRG) and inhibited by pertuzumab, 2C4 3273 5728 5163 PMC3923765__F2 BiNA: A Visual Analytics Tool for Biological Network Data 356 8743 355 7132 7124 4792 7186 843 1439 4914 100506742 8837 581 9020 572 4790 317 596 836 840 839 1677 472 7157 PMC3924248__F1 Contribution of MTHFR, MTR and MTHFD1 in the folate metabolic pathway 4522 4548 4524 5212 PMC3924561__F1 Functional Relevance of Biased Signaling at the Angiotensin II Type 1 Receptor 1977 572 1956 1839 387 PMC3926967__F2 Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections 3454 3455 7297 3716 6774 3667 8660 PMC3931066__F7 Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle 5111 7508 7507 545 84126 11073 PMC3935825__F1 Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography 10135 203447 952 PMC3936121__F7 MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family 4585 1633 6240 PMC3938851__F1 Insulin/IGF-1 signaling and regulation 3479 3667 7249 7248 6009 8408 2887 PMC3940872__F7 Synthetic Alpha-Bromo-2′,3,4,4′-Tetramethoxychalcone (Alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway 3717 3726 5008 PMC3941008__F1 Complement activation pathways 718 717 2271 PMC3941921__F5 Downregulated network of CANB1 in traumatic brain injury (TBI) 5530 5532 5535 PMC3943304__F5 Activation of growth factor receptor protein tyrosine kinases results in autophosphorylation on tyrosine residues 5728 5163 572 4193 PMC3944655__F1 Molecular mechanisms linking ROS, antioxidants, and the insulin signalling pathway 5728 3667 8660 23410 PMC3947295__F1 Scheme of the metabolic pathway of n-6 and n-3 long-chain polyunsaturated fatty acids 9415 2717 60481 3992 54898 PMC3949025__F11 Scheme depicting the inhibition of smooth muscle contraction via CB1 receptors 2869 5999 387 6010 PMC3950548__F2 Representation of IL-33 pathway in T-helper cells 90865 4615 3654 51135 7189 PMC3959225__F5 Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome 3479 351 572 PMC3960190__F1 Perspectives of TGFB inhibition in pancreatic and hepatocellular carcinomas 619501 7049 2885 4087 4088 4092 4091 4089 2475 PMC3962153__F2 Products for which C 2597 5183 7808 5132 140805 7068 PMC3965010__F1 Example of disease curation and visualization in Reactome 54020 2542 57818 1178 23152 PMC3965671__F4 Immunopathogenesis of inflammatory bowel disease (IBD) 2638 1893 999 3553 90865 6364 2919 2920 3576 64127 4295 PMC3966702__F7 ABCA1 expression and function can be induced by GPR119 to protect from atherosclerosis 139760 7124 3553 19 335 PMC3970144__F6 HCV assembly involves a concerted action of all viral proteins and hijacks the host lipoprotein synthesis pathway 348 57762 8694 338 PMC3970201__F2 Self-consumption: the interplay of autophagy and apoptosis 7124 4170 9140 6714 10533 2021 PMC3973904__F1 Cholesterol metabolism, lipid rafts and autism spectrum disorders 7956 627 3156 3949 19 10858 6713 26047 PMC3974768__F8 Stem and Progenitor Cell Subsets Are Affected by JAK2 Signaling and Can Be Monitored by Flow Cytometry 4355 4356 962 942 4354 PMC3975365__F2 Tumor’s interaction with its solid microenvironment 572 1499 2885 6714 PMC3975838__F1 Janus kinase 2 (JAK2)/signal transducer and activation of transcription (STAT) and hedgehog (Hh) signaling pathways in normal development (A) and mechanisms of Hh signaling in cancer (B) 3717 6608 2735 2737 2736 51684 596 595 5292 4170 PMC3976256__F9 Mycobacterium bovis BCG Triggered MyD88 Induces miR-124 Feedback Negatively Regulates Immune Response in Alveolar Epithelial Cells 7096 10333 51284 7099 7098 54106 7097 114609 4615 7189 PMC3978192__F2 Pathophysiology and pharmacology of hepcidin 148738 3570 7036 3077 4090 4086 6774 PMC3978640__F6 Blocking the transforming growth factor B (TGFB) signalling pathway 7939 4089 4087 4088 7046 PMC3979327__F3 MicroRNA networks regulate development of brown adipocytes 3224 8841 4617 PMC3979452__F4 MiRNA regulation of skin fibrosis in epithelial and fibroblast cells 4087 4088 4089 4092 6935 5728 9839 4312 PMC3979678__F3 Global Changes in Gene Expression of Barrett's Esophagus Compared to Normal Squamous Esophagus and Gastric Cardia Tissues 7040 7039 6750 928 3557 5055 2331 3606 7077 1113 3597 948 4585 214 667 768 216 4170 7082 113 831 29766 6698 7026 3866 4286 6715 7538 901 5366 PMC3980610__F1 LIF/JAK/STAT3-mediated growth inhibitory signaling in medullary thyroid cancer 3976 6774 5979 1869 3977 PMC3980725__F1 PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancer 1956 3667 5728 8821 PMC3980897__F1 Dual-view setup of the enRoute visualization technique 1956 2885 50964 4893 3265 3845 369 PMC3982918__F1 Notch signaling pathway and agents in clinical development 3714 182 54567 28514 10683 5045 4609 896 PMC3986830__F1 DREAM complex: Master coordinator of cell cycle dependent gene expression 1019 1869 55294 1017 1859 9113 26524 2305 PMC3989185__F8 Stiffness-Activated GEF-H1 Expression Exacerbates LPS-Induced Lung Inflammation 6010 3383 4015 PMC3989729__F7 A schematic diagram illustrating the interplay between TLX and the BMP-SMAD signaling pathway in the regulation of neurogenesis and astrogenesis 652 4089 2670 PMC3992244__F2 Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer 5728 14 2475 253260 7249 7248 23411 PMC3994981__F1 PI3K and Cancer: Lessons, Challenges and Opportunities 5290 5728 2475 PMC3995778__F4 Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies 2911 2913 2917 2904 2891 4046 8554 50944 22941 285195 PMC3996895__F2 Canonical NFKB signaling network regulated by miRNAs 4615 1540 27250 PMC3997009__F1 Routes of presentation of viral peptides on DCs 940 941 942 958 920 PMC3997674__F1 Dual opposing signaling pathways of TRAIL 8772 7186 637 596 PMC3997957__F1 Cell cycle arrest by CDKN2A 1029 4193 1019 983 PMC3998841__F2 Inflammatory cytokine-associated idiosyncratic drug hepatotoxicity as a “network toxicity” 7124 637 581 839 PMC4000931__F3 Summary of the miRNAs and the VEGF pathway involved in HSCs 161742 842 595 PMC4007119__F6 ZZ primary bronchial epithelial cells show an enhanced inflammatory response dependent of the ERK/EGFR/ADAM17 pathway 1956 6868 7039 374 PMC4008360__F3 Ingenuity pathway network analysis of differentially expressed miRNAs 79848 22875 100820829 3589 1385 377677 57539 1813 PMC4009444__F2 Intracellular signaling pathways for hepcidin expression 3569 654 148738 3077 4090 4086 PMC4012311__F11 Regulation of TRN mechanosensation 5266 5163 207 208 PMC4015830__F2 Intersection of BC modules 143, 79 and 82 11146 8411 1613 6502 342574 1026 890 7343 3645 8660 2065 23624 5934 2066 1018 53832 3560 PMC4019832__F2 Activation, signalling and targeting of ErbB receptor family members 2885 5728 2475 4609 3725 2353 PMC4023047__F3 Role of POR in biosynthesis of androgens in classic and alternate pathways 1586 5447 6770 1583 2232 2230 6715 1646 3284 3293 8630 6716 PMC4025940__F1 Roles of TGFB in the tumour microenvironment 7046 4089 7048 2475 PMC4028332__F2 After the banquet 5563 65018 8165 5594 10566 23411 155061 10891 7528 7019 9361 4609 PMC4028786__F1 Homocysteine metabolic pathways 1312 4397 4524 875 PMC4036287__F9 Working model for Fas signaling in cancer-related inflammation and breast cancer progression 355 8772 26136 1431 PMC4037353__F1 MicroRNA regulation of the germinal center response 7054 6095 29851 23035 5728 2638 1236 920 604 9612 PMC4037996__F1 Intracellular signalling pathway originating at EGFR and inducing the activation of proliferation, inhibition of apoptosis, and differentiation of epithelial and cancer cells 1950 7039 1956 5728 5594 2475 3725 4609 2002 2353 PMC4037996__F2 Role of normal and mutated KRAS protein in the regulation of the signalling pathway associated with EGFR activation 1950 1956 3845 PMC4039984__F1 Chromatin Landscape and Transcription Factors in T-Cell Programming 920 2625 6775 864 6778 6774 3662 10538 50943 861 PMC4041457__F4 The SDSA (synthesis-dependent strand annealing) and DSB repair sub-pathways 641 348654 80010 51750 80198 84464 146956 PMC4043133__F9 Proposed site of PEP7 inhibition of the AT1R-Erk1/2 signaling cascade 367 1956 1950 PMC4048856__F2 HEPCIDIN AND IRON HOMEOSTASIS 148738 654 7036 3077 PMC4050178__F1 Brief Overview of DNA Damage Repair: Three common types of DNA damage are depicted in this image as well as an summary of the pathways/proteins that are activated in response to each type of damage 6741 472 7515 545 84126 PMC4051134__F5 Targeting JAK2 in the therapy of myeloproliferative neoplasms 2057 5292 11040 PMC4051158__F5 The CD40-CD40L pathway plays a critical role in CD4 T-cell–mediated IL-21 production during the rescue of exhausted T-cell response 958 920 50615 PMC4051924__F5 Top-ranked signaling networks related to Na+/K+/2Cl- cotransporter 1 downregulation according to ingenuity pathway analysis 23310 9156 122953 9055 2177 324 991 57405 699 100188776 3725 1674 990 1870 8318 PMC4055129__F1 Inhibition mechanism of MTX in DNA synthesis pathway 4552 2356 1719 PMC4055208__F8 Scheme representing the insulin signalling pathway, the mechanisms involved in the high glucose-induced impairment of the insulin pathway and the proposed mechanism by which PPARB agonists prevent high glucose-induced insulin resistance in HUVECs 3667 5163 5166 PMC4055784__F2 The interactome space of the edible plants associated to colon cancer 5901 43 10750 PMC4055851__F2 Resistance to anti-EGFR moAbs in mCRC 1956 5728 2475 PMC4061222__F1 Roles of Wnt5a in cancer metastasis- (A) promoting and (B) suppressive processes 7474 4920 6478 382 7099 1499 PMC4063740__F8 Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway 1950 1956 2885 6722 PMC4066667__F3 Current understanding of molecular mechanisms regulating spermatogonial stem cell (SSC) self-renewal in mice 2668 1950 2534 4067 3055 2119 3975 255877 6875 PMC4067728__F3 Molecular actions of 1,25(OH)2D3 in inflammation and energy homeostasis in adipocytes 7421 7099 3553 PMC4069059__F7 Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells 11035 842 197259 8737 836 3725 PMC4072077__F1 MicroRNAs (miRNAs) are involved in pathogenesis of multiple myeloma (MM) by targeting some signaling pathways in myeloma cells 993 3654 57161 6774 55723 5716 8651 4193 3480 3479 PMC4072689__F5 Hijacking of Host Cellular Functions by an Intracellular Parasite, the Microsporidian Anncaliia algerae 6773 3665 10379 3434 3433 4599 3437 8668 27335 3094 4131 5829 2335 51474 PMC4073101__F3 Cilia and cilia-associated proteins in cancer 2475 7039 6790 4739 7428 4920 4313 6774 3939 595 1956 3082 6714 PMC4075356__F6 An Irf6-dependent pathway regulating keratinocyte migration 3664 9411 999 PMC4076637__F6 CDK4/6 is downstream of multiple pathways 2064 1021 1019 PMC4081859__F2a Complement regulation of T cell immunity 324 727 940 920 PMC4083752__F1 Unexpected targets and triggers of autoimmunity 149233 6446 5163 2309 2308 7043 PMC4084821__F3 Irinotecan Pathway, view of a model human liver cell showing blood, bile, and intestinal compartments, indicating tissue-specific involvement of genes in the irinotecan pathway 1066 8824 590 10599 4363 324 1576 1577 54658 54600 1244 5243 9429 PMC4086428__F4 Predicted network linking pancreatic cancer miRNA markers, known pancreatic cancer genetic lesions, and DAMPs 3845 3146 6285 4089 672 596 9839 6935 675 PMC4086757__F1 Classification of resistance mechanisms to BRAF inhibitors 3480 5159 4893 673 5728 2475 1019 PMC4091735__F1 Evading apoptosis in cancer 572 90427 8739 638 637 581 666 331 PMC4092141__F1 cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis 5266 207 6497 PMC4093113__F2 Pathway analysis of the candidate genes 5465 22944 2147 338 PMC4094071__F8 AEG-1 regulation of HIV-1 neuropathogenesis 7124 7528 3606 PMC4099420__F6 Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis 9466 3459 54106 4615 51284 8651 4938 4939 8638 3433 4940 9447 10346 3434 6737 6850 4599 85363 5610 200316 64135 3665 2268 3394 60489 3669 103 51316 PMC4100138__F2 Autophagic cell death in lung tumor cells 5728 8408 9706 2475 1612 PMC4106421__F2 ARF impinges both on developmental processes (male germ cell development and ocular development in mice) and tumor angiogenesis 472 5155 5159 PMC4107103__F6 Hypothetical model of molecular determinants of CLL cell survival, proliferation and migration in the PB, BM and LN microenvironments 6348 6850 613 695 857 10538 10563 5971 7186 894 3569 643 1236 7185 2208 5970 7852 960 597 6387 PMC4107712__F1 Illustration of the PI3K/Akt/mTOR pathway 1956 5163 5728 64798 7249 7248 6009 PMC4108232__F1 Mitochondrial dysfunctions in cancer 1431 2271 718 408 PMC4110034__F1 Microbial Egress: A Hitchhiker's Guide to Freedom 197259 8737 11035 836 581 834 PMC4110479__F3 Tolerogenic properties of plasmacytoid dendritic cells (pDCs) 958 29851 51284 54106 85480 6367 196 6774 50943 6714 3716 3002 941 942 940 920 PMC4110518__F1 Cellular origin of thyroid carcinomas is shown 7849 7157 673 PMC4110625__F1 Model of ER stress-associated inflammation 22926 7189 7494 7186 3553 PMC4114922__F4 Function and regulation of the Rho guanine nucleotide exchange factor Trio 1630 7204 2534 5879 PMC4114922__F5 Function and regulation of the Rho guanine nucleotide exchange factor Trio 1013 3383 7204 391 5879 999 7412 2114 6926 PMC4117150__F3 The Sonic Hedghehog (Shh) signalling pathway: Activation of signalling pathway is connected to various transmembrane proteins (Ptc, Smo), transcription factors (Ci/Gli) and protein kinases (Su(fu), fu) (Reproduced with permissions from Reference 31) 6469 6608 51684 PMC4118286__F1 Major physiological functions of the endoplasmic reticulum and their perturbations cause ER stress and activate the unfolded protein response 22926 468 83939 PMC4118478__F1 p53 at the crossroads of MPN treatment 7173 3717 3716 7297 6772 6773 2475 4193 PMC4118498__F1 Clinical Reasoning: A 20-year-old woman with rapidly progressive weakness 210 9049 3145 4151 5498 PMC4124034__F3 Translational Control by Heme-Regulated eIF2A Kinase during Erythropoiesis 5979 83939 468 PMC4125416__F2 Adaptive immunity with Toll-like receptors 2475 4615 1977 3665 7189 PMC4128256__F7 Models of Ras signaling in NF1-deficient GBM cell lines 4763 5728 2475 PMC4128997__F2 Antigen processing and presentation pathway 3458 821 811 6892 567 1508 920 4261 PMC4131167__F6 Rewiring of apoptosis pathway in breast cancer patients with and without recurrence 4914 836 5577 581 3553 208 5534 23533 331 1439 11213 4790 5576 572 7124 PMC4131167__F7 Differential dependency network presented over the KEGG] apoptosis pathway 8772 8717 7186 637 7939 3562 472 572 PMC4132214__F1 Transcriptomic differences between OVCAR3 and SKOV3 and PCA after interaction with the mesenchymal cells 2065 1906 7077 8829 1831 2064 860 627 7291 6474 1029 1052 6591 22943 5091 PMC4134368__F2 Biosynthesis of spiruchostatins 717 6689 275 PMC4135535__F3 Challenges in Vaccination of Neonates, Infants and Young Children 933 613 958 5336 PMC4138319__F3 miRNA- and TF-mediated sub-network specific to the TGFB signaling pathway 1021 6935 51434 3659 7048 4092 23037 1019 171024 81539 7534 2729 8322 260425 3696 64759 160418 3572 9806 9444 27347 488 122786 4323 PMC4138453__F3 Metabolic pathway of arachidonic acid via 5- lipoxygenase 4049 4050 1442 PMC4142901__F1 Hh signalling and cancer: Growth factors can increase the concentration of ligand which prevents the inhibitory effect of PTCH 4488 50846 6469 3549 2932 51684 2735 2736 2737 596 374654 PMC4147769__F1 Simplified outline showing key proteins within the extrinsic and intrinsic apoptotic pathways in response to extra- and intracellular stress 8772 637 841 842 836 PMC4148307__F8 Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation 2776 2767 2475 PMC4149521__F4 Gene Expression Profiling Reveals Epithelial Mesenchymal Transition (EMT) Genes Can Selectively Differentiate Eribulin Sensitive Breast Cancer Cells 629 2247 1950 3082 4851 1909 1956 387 6722 60 6667 PMC4150931__F1 Signaling pathways that induce epithelial–mesenchymal transition (EMT) 2932 387 6010 55364 PMC4151049__F2 Biochemical Signaling of PD-1 on T Cells and Its Functional Implications 2534 10125 5728 1374 27040 PMC4152414__F2 Coactivator dependent signaling regulates various biological functions, and deregulation causes diseases 3569 406 9575 PMC4152724__F2 Immunoregulatory molecules are master regulators of inflammation during the immune response 405 324 7535 1647 3458 6774 6772 941 PMC4155598__F8 CDK 4/6 inhibitors sensitize PIK3CA Mutant Breast Cancer to PI3K inhibitors 2475 1021 1019 595 PMC4159616__F1 Bile Acids, Obesity, and the Metabolic Syndrome 1593 9420 1582 25801 PMC4160455__F1 Multiple mechanisms lead to the development of PPCM in mice 6774 5617 2066 4893 PMC4161047__F1 Pathways implicated in type I IFN production following L 51428 115004 10392 64127 57506 3661 PMC4162362__F1 The sphingolipid signaling pathway 124976 8877 56848 PMC4163887__F1 Role of Toll-like receptors during RSV infection 7099 7097 10333 4615 7098 51284 PMC4164812__F1 BRAF inhibitors on melanoma and immune cells 673 4286 6347 PMC4166933__F1 Multiple leptin signaling pathways 3717 9021 5140 2885 6774 PMC4167409__F1 Androgen biosynthesis in prostate cancer cells 1586 3283 1646 8644 1645 8630 PMC4167483__F1 Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome 374654 51684 6608 64399 132884 84455 2121 23288 595 PMC4167483__F2 Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome 6608 51684 7124 2475 2932 4040 4041 1950 4088 2736 595 PMC4168754__F1 Cardiac Hypertrophic Response pathway loaded as a pathway 100188863 10014 208 11201 9759 1022 1311 2932 2475 PMC4170681__F1 The genetic signatures of pediatric high-grade glioma: no longer a one-act play 1021 1019 595 894 896 PMC4177877__F1 Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis 2932 6608 1499 PMC4178909__F1 The role of the VHL elongin BC complex in the HIF1 pathway in normoxic, hypoxic, and pseudohypoxic conditions 6921 9978 7428 6923 8065 8453 5163 5211 PMC4180627__F1 The endocrinology of vitamin D 5741 846 1591 8074 7421 1628 PMC4182169__F2 Nutrient-induced cell proliferation in the crypt 1499 648 8549 PMC4187706__F9 Schematic model showing AngII regulation of HSD3B1 in H295R cells 3283 3284 1585 PMC4190578__F5 Metabolic pathways for carbohydrates, fatty acids and phenylalanine 5226 2444 7358 790 PMC4192274__F2 Genes from the PPAR signaling pathway that were in regions surrounding QTL associated with at least one trait using the Bayesian approach 9415 28965 1579 284541 6256 PMC4194117__F1 SIRT2 controls the pentose phosphate switch 2539 22933 23411 PMC4199593__F5 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana 716 717 718 2161 5624 5627 2160 2158 7450 7056 2157 2153 2155 2147 2159 2152 PMC4201175__F1 Biochemical and genetic processes in malignant mesothelioma 8314 4771 5728 7157 4193 PMC4203662__F1 Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment 5163 5728 6446 PMC4207242__F1 Pathways Modulating GLI1-expression/activity in Cancer 7040 6469 6608 3845 1956 1950 2735 596 PMC4207979__F1 One-carbon metabolism is required for the synthesis of purines, thymidylate (dTMP), and methionine 10797 6472 4524 7298 1719 27232 PMC4211430__F7 Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice 887 3549 6608 PMC4212018__F1 Adaptive resistance to RAF inhibitors in melanoma 5159 2064 1956 4893 2885 673 2065 4286 PMC4214092__F1 Senescent cells in ageing 545 472 57546 5163 1017 1021 1019 PMC4214202__F1 Simplified model of the potential contributions of selective sensors and cell types to IFN production during viral infections 2829 5132 115004 7098 51311 51284 54106 7187 10010 4615 51135 7189 29110 3654 3661 3665 4827 PMC4216462__F1 TGFB signalling pathway in the early mouse embryo 9573 4838 652 650 6997 4090 4086 4087 4088 4091 4092 4089 7018 3398 3397 3399 91734 PMC4219530__F1 Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation 10454 330 2919 7124 114548 84674 6347 5595 9051 29108 260434 8517 7189 58484 1147 3551 64170 5602 10392 8767 64127 841 4210 834 3553 PMC4219936__F1 Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice 1581 1582 4280 PMC4223001__F1 Harnessing Hippo in the heart: Hippo/YAP1 signaling and applications to heart regeneration and rejuvenation 4018 6010 1499 154796 4771 6714 PMC4223072__F11 Epithelial AvB3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components 7097 4615 3654 6714 51135 6850 64170 3661 3558 3586 PMC4223419__F1 Cellular pathways of prostaglandin (PG) metabolism 5321 5742 5743 5730 5740 27306 9536 231 80142 8644 10728 873 3248 10257 6578 PMC4225745__F1 Interaction between human GD T cell and tumor cell 3458 3652 920 7054 4277 100507436 3627 10563 PMC4226683__F6A Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease 2920 2921 6372 6374 3577 2919 3579 6364 4318 4319 4314 4312 6347 3569 7474 51561 PMC4229247__F4 Pathways for initiation and maintenance of psoriasis 920 7124 54106 51284 PMC4230790__F3 Key signaling nodes in prostate cancer that regulate epithelial plasticity 2621 3569 999 1499 1956 2146 1191 6774 5728 367 1000 2078 PMC4231421__F7 LPA-dependent platelet-induced tumor cell metastasis 1950 5091 4018 PMC4231433__F1 Wired on sugar: the role of the CNS in the regulation of glucose homeostasis 4160 5443 2475 9049 PMC4231685__F9 Metabolic and transcriptional profiles for components of the TCA cycle (A) and BCAA biosynthetic pathway (B) 100996949 5131 50 48 4191 4190 3417 3418 PMC4233146__F1 Dendritic Cells and B cells: Unexpected Partners in Th2 development 4049 3558 10563 643 2625 920 942 941 613 3566 940 29851 4055 PMC4233246__F7 A model of how a p66B/Sufu complex inhibits Gli transcriptional activity and a Mycbp/Gli complex enhances Gli transcriptional activity in the nucleus 26292 51684 2736 2735 PMC4234565__F3 Circadian pathways 23220 2321 7422 3791 3479 5295 2064 2065 2066 3480 930 3575 2475 7097 PMC4237677__F3 Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders 2147 2152 5901 PMC4243082__F1 Regulatory network of cell-fate decision upon DNA damage involving (A) the G1/S checkpoint arrest network and (B) the senescence regulatory pathway 545 472 11200 1111 4193 993 5925 PMC4248707__F2 mRNA decay pathways in the cytoplasm 9924 167227 54464 PMC4250958__F1 Differential Apoptosis in Mucosal and Dermal Wound Healing 8717 835 841 54205 842 836 839 840 PMC4255606__F4 Proposed role of stem-progenitor cells in leiomyoma pathogenesis 1499 8091 9968 PMC4257614__F4 Accounting for eXentricities: Analysis of the X Chromosome in GWAS Reveals X-Linked Genes Implicated in Autoimmune Diseases 2962 10513 80258 10188 55268 8751 9853 9464 351 4168 140880 2491 1058 3596 9759 7046 3598 139599 3066 8322 102724473 729442 2857 10672 7874 29780 826 3320 92597 6097 26150 57697 3958 10678 PMC4258146__F2 Canonical Wnt/Beta-catenin signaling 22943 4040 4041 2932 PMC4259167__F1 Anti-tumor functions of GD T cells 355 11119 4277 100507436 942 958 9308 10563 PMC4259949__F1 Base-excision repair 4968 5426 7515 PMC4260922__F2 Transcriptomic Immune Response of the Cotton Stainer Dysdercus fasciatus to Experimental Elimination of Vitamin-Supplementing Intestinal Symbionts 4615 8027 51295 PMC4264883__F4 Downstream Targets of Lmo4 Are Modulated by Cisplatin in the Inner Ear of Wistar Rats 7297 8543 3716 50508 6774 596 672 6772 PMC4266326__F2a Comprehensive analysis of the transcriptional response of human decidual cells to lipopolysaccharide stimulation 9235 3456 11009 64806 PMC4269339__F2 Signal transducer and activator of transcription 3 (STAT3) pathways involved in immune escape 1950 3458 1956 6772 6774 6890 6891 PMC4269730__F5 Transforming growth factor (TGF)-beta signaling pathway 7048 659 4086 4087 4090 4091 4092 4089 PMC4270061__F2 Cofilin pathway in breast cancer invasion and metastasis 1956 1950 6010 PMC4271074__F8 OAA effects and inter-effect relationships 2475 4899 6356 1641 PMC4276135__F2 Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling 3575 29760 3662 896 3399 5896 5897 PMC4276281__F2 Schematic of the major pathways of serine metabolism in a mammalian liver 26227 29968 5723 PMC4278548__F1 Central metabolic routes and the aromatic compounds biosynthesis showing key metabolites and the genes involved in their transformation 1636 14 11113 5539 100187761 4118 PMC4279092__F2 Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis 10148 6774 967 2475 9776 PMC4284625__F1 Genetic pathways, prevention, and treatment of sporadic colorectal cancer 7157 324 581 673 PMC4285107__F1 New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish 55733 2735 6469 PMC4287430__F1 Predicted model of the S 27040 5836 2821 6120 4018 1431 2271 4967 5662 4975 100187907 1638 PMC4288522__F1 Intracellular signaling of mTORC1 and mTORC2 4763 5163 5728 7249 7248 6009 4771 64798 6446 3667 PMC4288710__F7 Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms 3937 5329 7852 54899 929 5880 PMC4292048__F3 TRAF4 function on TJs 64750 9618 9958 57154 387 PMC4292903__F2 Biomarkers Linking PCB Exposure and Obesity 1356 4838 2249 2247 2298 79923 2308 PMC4294505__F9 CCR7-stimulated phosphorylation-inhibition of AMPK 6363 6366 1236 PMC4294653__F11 PLB regulates apoptosis signaling pathway in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis 355 637 572 596 581 4170 56616 27429 54205 317 57448 790 PMC4294653__F13 mTOR signaling pathway regulated by PLB in DU145 cells.Notes: DU145 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis 3643 3667 253260 1975 1977 1999 8408 9776 3091 6194 PMC4299200__F1 De novo and salvage pathway synthesis of dTMP in the nucleus 4522 4524 6470 4548 7298 1719 PMC4301309__F1 Central role of NMPRTase (Nampt*) in the salvage pathway for NAD biosynthesis and related cellular functions 10135 23057 64802 349565 PMC4302087__F3 MiR-101 network regulates EMT 1499 9839 6935 2146 999 PMC4303015__F2 microRNA-21 Mediates Stretch-Induced Osteogenic Differentiation in Human Periodontal Ligament Stem Cells 353500 658 9765 55775 4052 7057 4092 93 4090 5308 64750 7048 130399 94 659 PMC4307931__F1 Collagen XIA1 in cancer promotion 4314 4318 780 4691 PMC4309737__F3 Actin polymerization disrupts ovarian Hippo signaling and promotes nuclear YAP actions to increase downstream CCN growth factors and apoptosis inhibitors involvement in POI, PCOS, follicle reserve, and infertility 1730 81624 60485 4485 9113 26524 668 1490 7003 8463 7004 7005 PMC4309737__F4 PTEN-PI3K-AKT pathway in oocytes regulates primordial follicle activation 5728 1950 3815 5163 PMC4316650__F3 Pathways and networks associated with proteins with differential abundance according to IPA 1356 1401 324 183 350 3929 3263 11202 7018 1431 2147 7276 5265 5730 3339 10747 3240 335 259 2934 2243 10960 1890 PMC4316689__F2 Activation of RAS–MAPK pathway induces expression of numerous genes, some of which can be targeted 6790 9212 6651 1058 10969 127845 1848 3832 23327 22974 11091 7018 PMC4318143__F8 A Dlg5-mediated bifurcation in Smo activity during Hh response 23432 6608 2736 374654 2737 9231 2735 PMC4319670__F1 Insulin signal transduction pathway 3667 5728 5266 8773 PMC4320069__F2 In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants 7015 688 4824 354 2263 3655 367 3817 9314 4477 4609 5010 2255 140628 6662 51176 4316 PMC4322317__F6 Protein Complex Discovery by Interaction Filtering from Protein Interaction Networks Using Mutual Rank Coexpression and Sequence Similarity 148156 9807 22894 23404 54512 23016 51010 23279 56915 51013 5393 55144 55627 PMC4323494__F9 Schematic model for the involvement of TAK1-NLK in IL-1Beta-triggered ATF5 stabilization and C/EBP activation 3553 23118 10454 51701 22809 10682 PMC4324508__F1 Microbiota modulation of myeloid cells in cancer therapy 545 5925 581 355 54106 7124 3458 7099 3146 PMC4335789__F1 Mechanisms that promote resistance to PI3K pathway inhibition 2475 5728 5163 PMC4336945__F3 Roles of Microphthalmia Transcription Factor and pigmentation in melanoma 5443 7306 1638 4286 PMC4338832__F2 Drug targets in the autophagic pathway to treat human cancers 8408 23192 100170220 PMC4343025__F1 Genome organization and biogenesis of microRNAs (miRNAs) 29102 54487 5901 192670 26523 27161 192669 PMC4345324__F8 G-protein-coupled receptor controls steroid hormone signaling in cell membrane 156 8558 7398 PMC4347898__F5 Phosphortlated Smad3 is stabilized by ERG in prostate cells 4087 4088 2078 PMC4347943__F1 wRAPping up early monocyte and neutrophil recruitment in atherogenesis via AnnexinA1/FPR2 signaling 2358 6347 6352 PMC4350105__F7 Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer 4087 7029 4089 4609 672 10735 PMC4351296__F6 Mechanism of dynamics of the EGFR-NHERF1-NHE1 signaling axis and its role in PDAC growth and invasion.In control cells EGFR, NHERF1, and NHE1 are separate 1950 1956 9368 PMC4355029__F4 RNA toxicity leads to activation of NFKB pathway 2597 329 5971 PMC4361049__F1 A stepwise demonstration of the hepatitis C virus internal ribosome entry site (HCV IRES) translation initiation pathway 3552 9669 1999 1998 83939 1939 PMC4361071__F1 Notch signaling pathway.(a) Schematic depiction of mammalian Notch receptors and DSL ligands 4851 4853 4854 4855 1950 5045 PMC4363231__F1 Potential canonical WNT signaling pathway- Resting state (a): SFRP4 binds free WNT molecules in the extracellular space and DKK binds the LRP co-receptor 6424 22943 284654 4040 4041 324 1499 PMC4370285__F8 Schematic model of EGFR stabilization by cigarette smoke 1950 1956 2885 PMC4376617__F7 The role of T cells in the anabolic activity of iPTH in trabecular bone 5741 7480 4040 4041 958 PMC4377297__F1 The role of trophoblastic microRNAs in placental viral infection 29102 192669 27161 PMC4377510__F5 Possible transforming pathway 355 11124 1499 1869 10642 PMC4381889__F1 NADPH production from the oxidative PPP and one-carbon serine catabolism pathway.Notes: Oxidative PPP uses glucose to generate NADPH via G6PD and 6PGD 10135 65220 2539 57103 PMC4381970__F3 Biological activities of TACI 29851 4615 7099 604 355 PMC4383535__F3 Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation 133 6955 7200 226 5315 3258 PMC4383600__F2 Interplay between multiple factors in the transforming growth factorB (TGFB) signalling pathway and the control of muscle mass 2660 25805 8200 4090 4086 4087 4088 4089 6497 PMC4384220__F1 PI3K-Akt-mTOR signaling pathway 5163 4193 572 7249 7248 5728 6009 PMC4385913__F1 Cytotoxic agents impact the Bcl-2 rheostat 572 90427 581 PMC4386979__F2 Intracellular signal paths coupled to the opioid receptors and implicated in cardiac stress signalling and cardioprotection 1950 1956 847 5163 6774 3717 2475 PMC4392267__F8 Proposed model for the involvement of TRIP in the TNF-induced inflammatory response 7124 8717 8877 7186 3550 3569 3553 PMC4392459__F1 The CoA-dependent butanol pathways used for the production of propane in E 3045 100187828 84890 196 PMC4392459__GA Propane synthesis derived from a fermentative butanol pathway is enabled by metabolic engineering 84890 3045 100187828 196 PMC4392874__F2 Network representations of the differentially expressed genes presented in pathway analysis 5609 7157 6789 595 4609 2113 3458 4087 11221 8797 596 408 7422 8743 2829 5604 5879 8976 3643 387 1378 3577 2353 3725 1956 2064 26279 3667 5590 5566 3590 5781 2885 867 10125 3561 2932 5266 5567 3845 5335 5295 22808 6714 4067 22800 7535 5467 1460 1445 2782 196883 5170 23236 2475 6198 5562 PMC4394621__F7 Kinase targets and inhibitors 1956 5728 2885 2475 8717 7186 2002 PMC4397892__F2 Inhibition of the classical apoptosis and autophagy pathway by Gamma-herpesvirus proteins 355 7405 637 PMC4404315__F3 Embryonic Stem Cell Self-Renewal 1441 8554 2057 9063 2690 10401 8027 3454 51588 10254 3455 3459 1270 10379 3460 1489 3590 23529 5292 1154 3589 3953 1387 3976 3977 5008 2033 9180 5777 53832 53833 6714 50615 64109 PMC4404318__F1 Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework 7099 7098 929 114609 695 4615 7189 7187 3661 3665 PMC4405118__F1 A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome 6608 6469 2737 2736 51684 PMC4408865__F1 An example of positive and negative regulation of the Ifn-signalling pathway 7099 3466 4118 4615 7297 3716 7098 7189 8651 6772 6773 81603 10379 3661 3394 6737 PMC4409267__F1 Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation 5091 5132 38 10449 355 39 30 PMC4409285__F1 Schematic intracellular network required for lipid metabolism, Apo B biogenesis, and CM assembly in the enterocyte 338 7038 1636 39 PMC4410875__F3a Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer 1499 1869 442917 5728 PMC4411872__F5 Genes involved in GPCR signaling Pathway: (G protein coupled-receptors are seven-transmemebrane receptors involved in signal transduction in humans) 652 650 2056 183 655 7040 3569 3586 7422 4852 7124 2784 PMC4414328__F8 We propose three possible pathways that could lead to liver NKT cell anergy 1499 89780 7474 2932 PMC4415653__F3 SP1, JUN and STAT1 subnetwork from the Brown module 6667 468 3725 4666 10987 6772 7170 11169 PMC4418220__F9 Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth 1431 4050 2920 PMC4418726__F3 RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem 790 1312 2805 PMC4420611__F5 Lysosome pathway 3423 8540 7404 20 51056 6955 PMC4422175__F8 Farnesoid X receptor (FXR) regulation of hepatic glucose and lipid metabolism in liver, adipocytes, and intestine 1581 2264 255738 717 355 5465 7038 3949 9965 4023 PMC4425424__F3 Transcriptional regulation of cranial sensory placode development 4487 2299 7545 PMC4427058__F7 The identified epigenetic regulatory mechanism involved in the miR-124/STAT3 pathway in pediatric-UC 6774 4318 596 PMC4433473__F4 Surface Fzd density by R-spondin-LGR5-RNF43 54894 84133 4040 4041 324 1499 6925 PMC4435535__F2 Notch signaling as a novel regulator of metabolism 3553 7350 100188776 7038 63976 10891 PMC4439431__F1 Metabolism of a resting uninfected cell 3156 31 47 2194 PMC4439968__F1 Toll-like receptor 4 signaling pathway 3146 7099 4615 7189 PMC4440424__F2 Class I PI3K pathway 5728 2885 5170 2475 253260 7249 6009 7248 572 4193 2308 PMC4444374__F1a Suppression of Antigen Presentation by IL-10 4615 8651 3654 29110 3661 1843 7099 PMC4444401__F6 Function of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent 3553 5008 3554 9180 3667 6774 4322 PMC4445654__F1 Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis 183 3482 5972 3816 1509 1511 59272 5476 2028 7064 5550 4311 57486 1636 1215 290 10072 6051 4142 186 185 1956 4012 1583 1585 1589 6718 1109 1586 1584 3290 3291 PMC4447524__F1 Resistance to BCR-ABL1 tyrosine kinase inhibitors may take the form of (left) point or compound mutation-based, BCR-ABL1-dependent resistance or (middle) recruitment of alternative pathway signaling upon effective inhibition of BCR-ABL1 1356 2247 6714 3717 6774 5447 PMC4449431__F8 Schematic model illustrating the possible pathway targeting NCI-H929 cell by HM910 595 1021 1019 572 PMC4449713__F4 Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy 6009 7249 7248 207 208 8408 9706 PMC4450280__F8 Estrogen regulates Delta-Notch signaling pathway of osteoclasts 4851 102 9612 5970 4853 2932 PMC4452864__F2 TGFB and ROS interplay 5045 7939 107966124 50507 PMC4459530__F1 Unexpected Functions of NFKB during Germinal Center B-Cell Development: Implications for Lymphomagenesis 4055 613 958 5971 5970 PMC4461477__F5 Emerging molecular machinery and therapeutic targets of metastasis 4312 4313 7412 PMC4466452__F1 Identified molecular targets involved in ELFEF-induced enhancement of adult hippocampal neurogenesis and osteogenesis 1499 9242 860 PMC4471797__F1 Wnt/Beta-catenin signaling pathway 999 2932 324 595 607 PMC4472234__F4 Elementary Flux Mode Analysis Revealed Cyclization Pathway as a Powerful Way for NADPH Regeneration of Central Carbon Metabolism 5805 5225 6120 3815 1431 PMC4490461__F6 Schematic representations of mammalian homocysteine metabolism 4397 4524 875 PMC4491511__F1 In response to diverse biological stressors, macrophage migration inhibitory factor (MIF) is secreted from preformed intracytoplasmic pools 4282 972 960 PMC4498995__F2 Metabolism and transport of acetaminophen in the liver at highly toxic doses 54600 7366 54578 54658 1544 6817 1571 6822 2944 2950 2952 1244 9429 10257 8714 PMC4502774__F1 Schematic stages of the autophagic pathway 9474 9140 10533 2475 83734 8408 9706 9776 60673 51100 7405 8678 55626 55014 5266 22863 596 64422 23192 PMC4505740__F1 Molecular targeting of the mitogen-activated protein kinase (MAPK), PI3K, and CDK4 pathways and the associated mutation rates of potential molecular targets in advanced melanoma () 3815 2066 2776 4893 2767 4763 5728 10000 572 596 2353 3725 1019 PMC4510836__F2 Complement activation on allograft injury 324 941 942 3458 920 1380 790 PMC4515436__F4 Short range signalling between the germline stem cells and their niche, which consists of the hub cells and the cyst stem cells 145258 999 1956 6608 PMC4516600__F4 A schematic pathway for one mechanisms of cisplatin-induced ototoxicity involves TRPV1 activation by cisplatin leads to NOX3-dependent generation of ROS to trigger STAT1 activation 7442 50508 6772 PMC4517435__F1 Core components of the insulin signaling pathway 5728 6464 25759 2885 3667 8660 5770 6655 6654 5170 4893 3265 3845 5894 207 10000 208 4133 5604 5595 5594 2002 8569 2872 2997 2998 PMC4518444__F6 Checkpoint clamp and clamp loader in crossover formation 545 5888 11144 PMC4518644__F4 Example of using “Inter-pathways” tool to query interactions between two pathways (left─syn00710: Carbon fixation; right─syn00480: glutathione metabolism) 1356 5185 51056 5184 8726 PMC4519337__F3 Transcriptome Profiling of Wild-Type and pga-Knockout Mutant Strains Reveal the Role of Exopolysaccharide in Aggregatibacter actinomycetemcomitans 4352 4351 55577 4668 4397 PMC4523298__F2 Significant edges for the proteins in the PI3K-AKT kinase pathway for breast (a) and ovarian cancer cell lines (b) computed using a Bayesian FDR of 0.10 5728 4162 100187761 57111 PMC4525315__F8 Model representing the implication of the GSK-3/Beta-catenin axis in IRF3-regulated RLR-dependent antiviral innate immunity 57506 2931 29110 3661 PMC4526101__F3 The type I diabetes mellitus pathway in which HLA-A, HLA-B, HLA-C, HLA-DPB1 and GAD1 are involved 3630 940 941 1363 920 3558 3458 355 5551 PMC4530889__F7 Dysregulation of the Transforming Growth Factor B Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia 7046 4087 4088 4089 PMC4533315__F4 ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis 2065 2064 7314 7311 3084 9542 10193 9101 208 6233 207 10000 4145 PMC4534355__F5 Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates 170082 7316 1356 6175 9128 7531 154796 8481 PMC4535695__F1 Classical pathway for T cell activation 941 942 940 PMC4541321__F2 Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case 5625 3550 109245082 PMC4548225__F2 LGR4-Wnt/Beta-catenin signaling pathway 84133 55366 4040 4041 8826 324 2932 1499 PMC4549066__F1 Activation signals for effector and regulatory T-cell division and proliferation 3558 3718 5728 50943 2475 11040 PMC4552438__F8 Paracrine networks acting downstream of epithelial ESR1 in the mouse uterus during implantation 3976 2099 3977 5241 1839 3549 5727 1956 650 PMC4554827__F4 Signal crosstalk with Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) 3084 1950 22943 4853 3689 9113 26524 374 3911 182 7791 1499 6910 4087 PMC4556375__F5 Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease 3276 27232 5091 3156 875 PMC4556464__F2 Hedgehog signalling pathway showing development of TNBC 6608 2735 2736 999 355 PMC4556939__F7 Proposed pathway of cAMP signaling after FID addition during in vitro maturation 1956 100188011 1843 885 9945 374 3099 3037 6770 PMC4556941__F2 Key mechanisms regulating vascular smooth muscle tone 1267 183 153 PMC4557770__F1 B cell receptor (BCR) signaling pathway and molecular interactions in the CLL microenvironment 613 695 4067 6850 6722 2475 7852 6348 643 1236 6351 958 952 6387 7412 PMC4559166__F1 Time-series transcriptome analysis for adaptive evolution of E 22934 6120 11113 6389 PMC4559943__F1 Schematic diagram of the assembled modules to convert galactose to n-butanol 85569 2582 2592 3045 100187828 PMC4562806__F2 New immunotherapies targeting the PD-1 pathway 1956 7422 5728 6774 6775 4772 PMC4563137__F5 Pathway enrichment analysis reveals PI3K/PTEN/AKT signalling and apoptosis pathway as the most significantly related pathway 2885 6654 9564 6464 5295 5728 5747 3688 5170 3611 207 1027 PMC4565673__F1 How to Turn On an Ancient Metabolic Enzyme? Add Insulin and Deacetylate 5230 2475 8841 PMC4568143__F1 From bench to bedside: what do we know about Hormone Receptor-positive and Human Epidermal Growth Factor Receptor 2-positive breast cancer? 3273 7039 1956 PMC4575550__F1 Effects of exercise on the signalling pathways associated with muscle growth and wasting in sarcopenia and cachexia 3479 4087 4088 2475 PMC4577901__F3 Signaling network of genes that are strongly upregulated following MARV challenge of NHPs 1051 3661 2353 3725 5789 668 1385 2920 6288 64332 PMC4580963__F1 Overview of Cr metabolism and the methionine cycle 4397 27232 2593 2548 PMC4583389__F3 Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma 685 100187761 10718 145957 PMC4584235__F6 MiR-146 a/b effect on induction of endotoxin tolerance 7099 4615 864 7189 6774 7124 PMC4584313__F2 Hedgehog Signaling in Malignant Pleural Mesothelioma 100187761 6608 2736 51684 2737 PMC4584352__F1 Anti-oxidative effects of astaxanthin in neurological diseases 9817 1728 6667 PMC4586474__F1 Pathways of tryptophan metabolism 3620 169355 23475 PMC4586487__F6 PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells 6428 5725 58155 PMC4587761__F3 Network associated with the proteins in 2822 4481 338 51738 4036 350 7436 5340 7130 10653 7035 721 720 929 1370 PMC4588544__F3 Current models for mitochondrial longevity 6874 2475 83939 PMC4588911__F1 IL-33/ST2 signaling pathway in mast cells 90865 6761 4615 51135 3654 7189 PMC4593313__F1 Cellular interactions in normal and diseased vasculature 2247 2249 2263 2253 7412 3383 5155 1003 2260 860 8074 PMC4593336__F1 Canonical Wnt3a pathway 89780 55959 4920 4082 324 1499 2305 960 4040 4041 PMC4598026__F5 Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells 254268 134147 440279 64579 827 57556 167410 27254 54829 387758 25849 1357 30061 4604 203447 80031 9037 10512 5055 PMC4599573__F2 PLB regulates cell cycle at G2/M checkpoint in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis 472 4194 672 246184 6790 79866 8231 1022 56475 1164 PMC4600500__F4 Interactomic analysis by ingenuity pathway analysis (IPA) of significant molecules 3576 3458 6347 5966 5970 PMC4600508__F2 Schematic overview of the multiple signaling pathways to apoptosis, necroptosis and autophagy 7124 8717 8772 11035 637 197259 PMC4604749__F4 Life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics 3190 4691 325 7249 7248 79016 6009 PMC4605373__F4 Apoptosis response pathway 355 356 7124 3002 8837 4049 3481 8717 27242 8772 837 8738 835 599 7186 7187 329 637 572 836 840 842 1147 6416 8739 5602 581 56616 54205 4793 3660 3665 3661 5970 6418 27113 666 1029 4609 3725 3551 8517 4193 3070 1676 PMC4607614__F6 Schematic representation of SA’s mechanisms of suppression of HMGB1’s proinflammatory activities 3146 7099 7852 PMC4607655__F3 Metaproteomics Reveals Functional Shifts in Microbial and Human Proteins During a Preterm Infant Gut Colonization Case 6810 7074 92359 2011 387 57530 8573 7408 100506658 5728 5872 7414 1499 PMC4609028__F1 Cell Cycle Regulators and Cell Death in Immunity 545 472 1869 PMC4611193__F2 The regulation of intestinal iron transport 3240 3077 7018 PMC4614799__F1 Driver genetic lesions in papillary thyroid carcinoma 5728 5163 2475 PMC4614807__F8 Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus 3454 3455 3716 7297 6772 6773 10379 3486 3434 3433 3437 PMC4618268__F1 Everolimus Combined With Gefitinib in Patients with Metastatic Castration-Resistant Prostate Cancer: Phase I/II Results and Signaling Pathway Implications 3480 1956 367 2289 PMC4619565__F7 Parallel activin and TGFB signaling in advanced colon cancer 7048 7046 90 4089 PMC4619950__F3 Main molecular pathways activated for the production of inflammatory cytokines 2056 3717 6778 6774 3082 6772 PMC4619950__F4 Molecular pathways activated by inflammatory cytokines and growth factors and affected by MPN-associated mutations 7173 2056 4352 4351 6774 6772 3717 3716 PMC4620040__F1 Inflammatory bowel disease (IBD) as a multifactorial disorder 7099 149233 3593 6774 1235 3717 3663 64170 64127 345611 120892 55054 9966 8771 5771 7128 114548 8807 3586 10109 7494 9231 1893 55600 6584 1755 5734 85480 912 PMC4622839__F1 PIK3/AKT/mTOR signaling pathway in acute myeloid leukemia 5728 5163 2475 253260 572 64223 1977 PMC4626012__F1 Role of epidermal growth factor receptor in acute and chronic kidney injury 1839 1956 6714 2475 PMC4629506__F1 TLR and NFKB signaling disrupted by PID 4615 51135 3654 3656 7189 23118 257397 7187 29110 3661 PMC4631256__F2 Epigenetic Mechanisms in Schizophrenia 627 5978 4204 PMC4631757__F10 The interaction between corneal stroma (canonical Wnt signaling) and epithelium (Bmp4 signaling) during mouse corneal development 4090 4086 652 1499 7008 4041 4040 PMC4631823__F1 Model for brassinosteroid (BR) signaling pathway in the absence and in the presence of BR 578 51411 55677 PMC4632638__F2 Ibrutinib: a first in class covalent inhibitor of Bruton’s tyrosine kinase 973 974 6850 4067 695 4615 84433 8915 10892 PMC4632748__F1 Simplified possible molecular signaling pathways (1 to 6) of estrogen (E) and estrogen receptors (ER) 1956 6714 27043 7018 PMC4632748__F3 Tamoxifen pathway and possible mechanisms of endocrine resistance in breast cancer cells 1956 6714 27043 PMC4633443__F1 Inflammasome axis 114548 929 55655 3553 PMC4633891__F10 MiR-148a promotes starvation-induced autophagic activity in HSCs, at least in part, through suppressing the Hedgehog signaling pathway 2619 6608 2735 PMC4633932__F2 Nutrient, growth factor, and energy sensing impinge on the mTOR pathway 6009 253260 2475 5163 PMC4640886__F1 Etomidate on the Steroidogenesis of Rat Immature Leydig Cells 3973 949 6770 1583 1586 3293 3283 6715 PMC4643408__F2 Signaling pathways associated with CRKL, GAB2, and FRS2.CRKL is activated by multiple types of cell surface receptors including integrin receptors upon binding to extracellular matrix (ECM), cytokine receptors, and growth factor receptors 1950 3082 2885 10818 1399 9846 PMC4646847__F4 Oligonucleotide discriminators of the TLR9-cholinergic links 43 590 54106 PMC4647710__F2 Canonical and noncanonical NFKB signaling pathways 4055 958 613 5970 PMC4648177__F3 IG20pa and MADD as antagonists in the TRAIL-induced apoptotic pathway 8567 8772 637 PMC4650770__F1 Biosynthetic pathways of histo–blood group antigens 51083 2524 2523 10690 2526 2525 2528 2527 3006 PMC4651103__F1 Working figure of the angiogenesis pathway genes 1959 2321 3791 1956 7046 3667 3553 7124 7421 PMC4657041__F9 The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia 29102 4088 2033 4089 5925 PMC4657124__F1 Wnt/Beta-catenin signaling pathway 4040 4041 324 PMC4659166__F7 Network of interactions between GWAS candidate genes using ingenuity pathway analysis (IPA) 29922 9919 57631 8481 6251 57480 85440 57187 26524 9113 57530 57670 100187761 55125 57568 PMC4659372__F1 PD-1 signaling in effector T cells 6502 941 940 9734 10013 51564 23411 50943 PMC4659438__F4 Molecular pathogenesis and potential treatments for thrombotic microangiopathy in the glomerular endothelium 1636 7018 3383 7412 7450 718 7124 324 PMC4660682__F10 Differential proteins in acute phase signaling pathway in DN summarized in this and previous studies 2353 183 325 2157 1431 PMC4661888__F3 Gene expression analysis of thyroid hormone synthesis pathway 50506 7253 7173 405753 7038 PMC4662481__F7 Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer 3716 5728 4609 PMC4664252__F9 Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade 3428 6347 6348 6351 6352 PMC4666900__F1 Simplified pathway diagram showing the Leishmania-APC and T cell interaction 324 3569 3565 3454 3455 3661 3458 6774 2002 3717 3586 940 6775 2475 3932 3558 7535 920 367 3567 6772 3570 3562 PMC4671655__F1 MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells 998 4193 7528 PMC4673535__F4 Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis 9429 343 4283 58191 PMC4673612__F4 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks 57154 5606 7329 4208 10987 7050 1432 57559 7189 1387 56288 3172 8945 1499 5575 3726 64750 387 100187907 1386 960 9146 2339 3727 595 6497 2354 7421 467 367 29882 672 2885 5747 9564 6093 409 1398 7049 6654 PMC4673612__F7 Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks 595 6925 1021 999 5300 6656 1000 54361 6423 1499 3728 8313 7476 1452 7471 324 8945 207 1601 6259 7472 3611 89780 4920 4216 22943 85458 5515 7473 5582 5578 5879 409 23002 5579 8322 1454 408 387 PMC4673661__F1 Osteocytes and Skeletal Pathophysiology 1499 50964 9881 PMC4676894__F3 Oncogenic (deregulated) intracellular signaling pathways in activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) 613 4615 914 973 974 3569 958 6850 965 6774 84433 51135 3586 8915 10892 3662 604 2033 596 3716 3717 PMC4676894__F9 Mechanism-based combinatorial experimental regimens aimed at disrupting known oncogenic cooperation pathways in ABC-DLBCLs 613 958 6850 4086 4090 84433 3716 3717 4615 8915 51135 596 4609 5971 3662 604 6774 5728 PMC4677197__F1 Canonical Wnt signalling pathway implicated in diabetic nephropathy 1499 2932 324 PMC4679480__F8 Green Tea component EGCG, Insulin and IGF-1 promote nuclear efflux of atrophy associated transcription factor Foxo1 in skeletal muscle fibers 3479 3667 2308 PMC4683091__F2 Position-dependent regulation of cell fate in the preimplantation embryo: known and hypothetical mechanisms 154796 1045 7004 3516 4771 PMC4684418__F1 Targeting Pink1-Parkin-Mediated Mitophagy for Treating Liver Injury 9101 9958 84749 65018 283514 9530 3305 PMC4685044__F1 Signaling pathways activated by cytokine receptor binding 3717 6774 4609 PMC4685734__F6 Apoptotic cell recognition receptors and scavenger receptors 84466 19 5879 PMC4686384__F5 Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins 8452 8453 26190 11124 23291 10492 23197 8945 26986 8761 6138 55294 10365 8462 687 360 688 10933 5868 11031 5869 57403 9673 PMC4694793__F3 Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy 1956 6608 4485 3082 5728 2475 596 PMC4694980__F3 A core of kinase-regulated interactomes defines the neoplastic MDSC lineage 4043 81 10409 3191 3190 392 PMC4695805__F2 Mitochondrial dysfunction caused by inhibition of pyruvate transfer to mitochondria 5163 5166 5165 5164 PMC4695848__F1 Functional role of deubiquitinating enzymes in autophagy 8975 10868 23032 9100 5899 57602 7416 9958 84749 9101 57558 PMC4696971__F2 NOD-Like Receptors in Infection, Immunity, and Diseases 64127 22861 199713 58484 4615 10392 114548 4671 55054 91662 55655 147945 84166 7189 PMC4698256__F1 Proposed cytotoxic mechanisms of NEDDylaton inhibition in human malignancies 81620 7465 64798 2475 PMC4700926__F1 The core autophagy pathway and its regulation by miRNAs 9776 3920 10533 9140 7405 83734 9474 55054 64422 596 55357 406952 693215 406971 406987 PMC4703580__F1 Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases 54209 8651 7189 23118 2308 467 114609 4615 PMC4704690__F1 Controlling the burn and fueling the fire - defining the role for the alarmin IL-33 in alloimmunity 90865 6761 920 374 3458 PMC4705964__F8 Working model for Gpr175 function as an enhancer of Hh signaling 51684 6608 5727 2735 PMC4707055__F2 CO2 sensing and CO2 regulation of stomatal conductance: advances and open questions 10006 759 762 PMC4707441__F2 Tetraspanins organize the T-cell immunological synapse 324 6010 920 975 928 977 3732 3383 940 942 941 5327 PMC4717619__F1 Schematic of tumor cell interactions in the brain 5728 4851 6387 7852 3714 3569 182 4919 1956 PMC4717906__F2 Pathway and Network Analysis of Cancer Genomes 1956 1950 26018 51232 3872 6464 6654 5753 PMC4718713__F6 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications 23429 637 8772 317 581 4193 6045 1616 PMC4721599__F4 Network of genes located within high-level copy number changes and deregulated across all of the cell lines and tumors 29028 8870 6790 64065 990 4609 6598 7153 1736 1843 27295 PMC4725315__F5 Ingenuity pathway analysis showing up (green) and down-regulation (red) of miRNAs involved in ovarian cancer tumor samples when compared to endometriosis samples 4133 5604 100302141 PMC4727530__F1 BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics 572 90427 638 8739 637 581 PMC4730344__F4 Induction of DNA repair by EGFR signaling 1956 857 672 207 472 675 5591 5888 PMC4731230__F2 MuSC function are altered in aging 10220 6774 1499 PMC4731283__F1 Evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies 84133 54894 50964 324 1499 607 595 22943 PMC4738049__F2 Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection 3455 50615 3718 7297 3717 5897 PMC4741457__F9 Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination 222484 8650 1499 4609 8313 PMC4742124__F1 Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma 3717 2885 6774 PMC4742205__F7 INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma 2735 6469 3642 2932 PMC4743686__F8 A proposed role of Coa6 in the mitochondrial copper delivery pathway to Cox2 388753 9997 6341 PMC4745742__F8 Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation 1805 387 6010 PMC4746004__F4 Collateral Lethality: A new therapeutic strategy in oncology 5226 6120 7086 PMC4747576__F6 Global MicroRNA Expression Profiling of Mouse Livers following Ischemia-Reperfusion Injury at Different Stages 3929 929 114609 59307 54472 353376 9618 23118 3725 2002 PMC4749494__F5 The effects of extracellular CypA and MM284 in experimental BA 7939 7046 4089 7076 7079 4316 PMC4754720__F4 Metabolic regulation of mitochondrial transport and mitophagy 8473 192111 139341 6009 8408 PMC4761092__F10 Scheme of the role of (+)‐naltrexone and (+)‐naloxone in TLR4 signalling 7099 3466 4615 3661 3603 PMC4762141__F4 Differential gene expression in glycolysis/gluconeogenesis pathway in AuNR-treated MDA-MB-231 cells 2821 2597 5162 1737 PMC4764764__F4 Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development 4855 4854 2078 3714 2113 26508 23462 1948 23493 7431 4072 2153 2152 1906 999 7040 688 2335 7130 79977 6935 PMC4768650__F2 Eosinophils contain and/or release a wide array of preformed and de novo synthesized mediators important for their effector functions 8288 4155 727 2919 3458 7423 7422 6361 6348 6347 6368 6374 3576 4283 6373 3553 3603 7018 100187907 PMC4768650__F3 Eosinophils modulate the functions of a multitude of cells of the innate and adaptive immune system 6361 8178 4155 4803 8288 PMC4778363__F3 Pathway map for paramylon and wax ester metabolism in E.gracilis 2147 95 717 2597 PMC4779544__F1 Proposed pathway connecting HMGB1, TLR4, TLR2, MyD88, and TRIF signaling to inflammation and regeneration following muscle ischemia 3146 7099 7097 4615 PMC4786283__F2 Stability of Ensemble Models Predicts Productivity of Enzymatic Systems 6120 7272 7086 2019 PMC4789422__F6 Module network of the core network biomarkers in to investigate the bladder carcinogenic mechanisms from stage 1 to stage 4 bladder cancer cells 7124 811 2923 11047 51726 10987 3309 602 6613 3320 7316 3725 55658 124512 2957 7917 7184 80227 23197 3838 2353 7018 1894 406947 406905 406983 406984 114614 6224 PMC4795442__F1 Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis 3126 4353 718 PMC4797633__F1 Complement system 720 1378 966 727 PMC4799835__F3 TRAF6 in T lymphocyte activation and differentiation 7046 940 7189 50943 2475 4087 4088 2625 PMC4801062__F3 ZBIT Bioinformatics Toolbox: A Web-Platform for Systems Biology and Expression Data Analysis 64146 5154 55512 1950 PMC4803542__F1 Monogenic Mouse Models of Autism Spectrum Disorders: Common Mechanisms and Missing Links 627 5728 23237 6009 7337 4204 PMC4805359__F4 Schematic representation of the proposed model to explain NHR-49/PPARA function in promoting the longevity of germline-less animals (modified from Ratnappan et al.,) 65095 10915 5465 6649 PMC4807283__F1 CerS are central enzymes in the sphingolipid metabolism pathway 79603 253782 29956 91012 10715 204219 2531 PMC4807992__F1 Prostate cancer stem cells: the role of androgen and estrogen receptors 367 6714 5879 595 9149 PMC4808588__F4 Multifaceted biology of plasmacytoid dendritic cells 54106 81622 3665 3663 695 4615 121260 29993 1794 5359 950 PMC4808760__F6 Kinetic models describing the in vivo metabolism of the HDL apolipoproteins on each HDL size fraction 335 336 5550 348 55937 324 337 345 6120 PMC4808853__F2 Long chain polyunsaturated fatty acid biosynthetic pathway 9415 3992 60481 54898 PMC4813224__F3 Argininosuccinate synthetase (ASS)-negative cell death induced by arginine deprivation 435 581 2475 PMC4813275__F1 Pathways that represent potential targets for miRNAs in drug-resistant GC 3480 3667 3549 100302203 5728 596 6608 PMC4816192__F1 Targeting of BCR and PI3K/AKT signaling as therapeutic strategy in CLL 4919 3480 613 4067 5336 29760 6850 2475 PMC4816337__F1 Quantitative Modeling of the Alternative Pathway of the Complement System 2271 1378 718 727 729 730 966 PMC4821530__F5 GUIdock: Using Docker Containers with a Common Graphics User Interface to Address the Reproducibility of Research 8242 1399 8233 10291 5290 6427 8405 11059 1030 673 4286 595 4170 3845 898 7494 598 4763 2146 PMC4821889__F8 Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGFB signalling pathways 6478 9113 26524 PMC4822108__F3 Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer 9894 7421 10902 8481 1499 54556 2099 6886 7157 8850 8295 1869 86 4609 56943 6881 672 4149 23326 1874 8464 6314 PMC4823071__F7 In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment 472 580 2305 PMC4824143__F1 Smad and non-Smad transforming growth factorB1 (TGFB1) signaling pathways 7040 10454 4087 4088 4089 1386 4092 PMC4826150__F1 Regulation of target genes by the Wnt/Beta-catenin asymmetry pathway 90196 10940 1499 PMC4826884__F2 Immune signaling in C 5163 208 207 6446 PMC4828651__F4 Transcriptome Variability in Keratocystic Odontogenic Tumor Suggests Distinct Molecular Subtypes 6469 64399 156 409 51684 PMC4833515__F3 Oxysterol-Related-Binding-Protein Related Protein-2 (ORP2) Regulates Cortisol Biosynthesis and Cholesterol Homeostasis 1583 3284 1584 1325 1585 PMC4833894__F1 Different molecules involved in the mTOR activation cascade 3667 2475 1977 PMC4835794__F2 Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns 7124 3479 3667 5594 54541 6794 5728 92335 7248 51719 5563 7249 10000 6009 1975 6199 3091 9706 PMC4835794__F3 Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns 3479 3667 5594 92335 51719 7248 5562 7249 5170 10000 6009 1975 673 3091 PMC4836751__F5 Transcriptional Profiling of Ileocecal Valve of Holstein Dairy Cows Infected with Mycobacterium avium subsp. Paratuberculosis 3932 23624 951 945 7535 952 2353 27040 3725 2885 10125 29851 940 PMC4837871__F2 Sex-determining Region of Y Chromosome-related High-mobility-group Box 2 in Malignant Tumors: Current Opinions and Anticancer Therapy 1950 1956 1499 55733 6608 6774 6657 9429 79923 PMC4838361__F5 PARI regulates the repair of single-strand gaps left behind the replication fork 6596 57697 84893 PMC4838829__F4 Genome-wide association studies for fatty acid metabolic traits in five divergent pig populations 79071 2194 23205 60481 6319 9415 79993 PMC4841712__F1 Regain control of p53: targeting leukemia stem cells by isoform-specific HDAC inhibition 472 55869 5292 23411 23326 PMC4842059__F3 Id2 network model in insulin signaling, thermogenesis, and adipogenesis pathways 652 3398 3991 2194 5465 10499 63976 6256 7291 7350 PMC4846800__F2 Resistance mechanisms in MAPK-inhibitor treated melanoma 4763 673 597 4286 1017 1019 PMC4847613__F6 Regulation of trophectoderm (TE) lineage specification by mevalonate pathway 3156 6010 7004 1045 2625 PMC4849016__F2 Regulation of RNase 7 induction 1956 6774 1386 PMC4850435__F6 Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions 3929 7099 23643 7100 7097 10333 929 7096 54472 5879 4615 54106 114609 51284 51311 7098 8772 841 4283 3627 6373 6348 958 3553 941 3569 6351 942 6352 PMC4852799__F1 Appropriate activation and feedback control of TP53 activity is critical to effective tumor suppression 7157 545 472 64326 PMC4854551__F8 Proposed model for the involvement of the EIF2AK4-EIF2A-ATF4 pathway in autophagy response to AIEC infection in intestinal epithelial cells 440275 83939 468 8878 81631 10533 64422 8678 PMC4856023__F3 The blockade of immune checkpoints in cancer immunotherapy 940 942 1493 PMC4859898__F4 mTOR signaling pathway regulated by CDDO-Me in Ec109 cells 2475 7249 5091 2233 253260 6009 1975 9776 1999 1977 PMC4861365__F1 The Fanconi anemia/BRCA repair pathway 84126 545 55215 2177 7398 672 675 5888 PMC4865921__F9 Schematic summary of the results 4803 835 836 3949 PMC4870076__F6 Potential mechanism underlying Qinggan Huoxue Recipe-mediated inhibition of epithelial-to-mesenchymal transition in alcoholic liver fibrosis rats 4089 4087 4088 999 PMC4870363__F1 Schematic overview of TLR signaling pathway in neutrophilic and eosinophilic asthma 7097 7099 4615 51311 7098 51284 3553 PMC4872111__F6 Downstream effects of miR-145 ectopic expression 2885 407010 4089 1616 4149 1030 5894 1026 5063 998 5058 407011 5606 5608 5062 898 1017 595 1147 1027 1021 1019 2002 1869 1386 PMC4874035__F7 Vascular control of the haematopoietic microenvironment by Slit/Robo signalling 100653366 998 100188011 474168 PMC4875723__F6 Systematic model of the Hippo/YAP signaling pathway affecting cytotoxic drug resistance in osteosarcoma cells 4485 9113 26524 PMC4878148__F1 Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer 1956 2064 5156 8660 5728 673 PMC4882508__F1 Pathway Compartmentalization in Peroxisome of Saccharomyces cerevisiae to Produce Versatile Medium Chain Fatty Alcohols 5191 5830 717 5824 PMC4885105__F2 Infection cycle of HCV 1956 29881 3949 9076 100506658 975 57762 PMC4885862__F3 Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy 7855 4040 51699 59349 64840 387 5879 1499 23135 57492 359948 9802 PMC4890888__F2 EGFR signalling pathway 1950 1956 2475 PMC4891224__F1 Is There a Future for AKT Inhibitors in the Treatment of Cancer? 3667 5728 5163 7249 7248 595 6194 PMC4891302__F6 Co-targeting Androgen Receptor Splice Variants and mTOR signaling pathway for the Treatment of Castration-Resistant Prostate Cancer 367 2475 11065 PMC4892133__F1 Rapid degradation of HIF-1A by the ubiquitin-proteasome pathway, during normoxia 2919 4282 2056 PMC4905168__F1 Noxa and cancer therapy 7345 581 2309 468 PMC4905256__F8 Hierarchical protein binding at the rDNA locus and intersections with SUMO 7150 10276 10592 10051 PMC4905335__F1 Mechanism of retention of BRCA1/BARD1 complexes at DNA double-strand break sites 472 3014 9656 9025 9555 7799 55611 165918 672 580 55183 PMC4905397__F1 Inhibition of tRNA synthetases restores glutathione from the effects of cystine deprivation in ferroptosis 4553 468 2879 PMC4905404__F2 Regulators of phenotypic plasticity 3082 960 9429 PMC4905428__F1 Regulation of Smad4 by the FGF/MAPK and Wnt signaling pathways 1950 4089 324 4087 PMC4910912__F1 Union of active TF-miRNA regulatory pathway in CDDP resistance 8091 597 3043 142 5328 3725 79727 6622 7040 4502 2335 6520 5743 6347 3880 6772 1050 5054 4582 2243 85414 5698 PMC4915121__F1 Conserved longevity-regulatory components of insulin/IGF-1 signaling pathway in C 9798 5163 207 PMC4917857__F7 Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis 51478 1581 10858 1583 1593 PMC4918253__F2 Canonical and noncanonical pathways of inflammasome activation.Notes: (A) Canonical inflammasome activation (canonical pathway) 7099 8205 3553 PMC4919052__F7 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq 5465 3172 5467 10891 7494 133522 6721 6720 PMC4920139__F1 Genes represented in the 38-gene DTC panel and their biological pathway associations 1001 1364 3912 3872 3856 3880 6274 4250 4072 3855 3487 2064 6422 5727 8643 6608 8487 2264 5159 595 2886 2099 27129 26353 2736 3169 4137 2737 6615 145258 6591 5308 7291 PMC4920993__F2 Predicted FA and TAG biosynthetic pathways in perilla seeds 5091 1356 4018 8694 84649 PMC4926487__F3 Schematic representation of the DNA repair system for neuroprotection implying that genome stability is sustained on several tumor suppressors 5728 672 472 PMC4931093__F1 Mechanotransduction in transcriptional regulation 154796 387 4118 6722 1499 PMC4932205__F4 Genes which are involved in the telomere maintenance and telomerase activity pathway 472 207 25 7157 7011 1736 26277 10111 7015 25913 7520 7012 4683 7014 7013 PMC4935227__F3 The potential role of WWOX in anticancer drug-induced cancer cell apoptosis 2475 9474 51741 PMC4935424__F4 Differentially expressed genes in BA, JA and UA groups mapped on the TNFR signaling pathway (1 denotes JA, 2 denotes UA, and 3 denotes BA) 8717 5871 847 8772 637 27429 331 581 PMC4935960__F6 Independent Tumor Origin in Two Cases of Synchronous Bilateral Clear Cell Renal Cell Carcinoma 11059 92912 7428 6015 8242 5728 11191 2475 1956 2255 6608 5727 51684 4086 PMC4938192__F1 Steroid metabolism pathway 8644 6715 1646 1645 9420 PMC4939711__F1 Oncogenic signalling and nutrient availability influence cell metabolism 3845 3091 4609 3939 2194 47 6510 2744 PMC4940412__F4 Glycolysis superpathway gene expression profiles 2023 6389 6392 6391 6390 PMC4941807__F5 Schematic illustration of the coagulation pathway and its inhibitor systems 7035 5624 5627 7056 2 3082 306 307 PMC4945639__F2 WNT/Beta-catenin signaling pathway in adrenal tumorigenesis 84133 4040 4041 2932 1499 324 PMC4946798__F2 Probing the complexities of astrocyte calcium signaling 4827 7226 90550 PMC4946926__F10 The proposed model for production of IFNB in response to extracellular dsRNA 7098 6714 7187 7189 29110 3569 PMC4955940__F1 T-cell activation is regulated by antigen presentation, as well as stimulatory and inhibitory co-receptors 920 941 940 7535 3932 3725 PMC4957332__F4 Changes in transcript abundance of genes involved in central metabolic pathways and bioprocesses in response to elevated CO2 in C-169 2539 2597 1431 435 5009 PMC4960658__F2 p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression 1956 2064 6714 5879 387 PMC4960920__F1 Schema of upstream and downstream signaling pathways of mTORC1 2932 7249 7248 6009 1977 PMC4961996__F2 Transmembrane signaling by TGFB 4088 4089 4087 57154 387 2475 PMC4965259__F1 Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors 2885 2549 5728 2475 PMC4965740__F9 Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways 9968 10001 55582 2737 1024 7101 5469 27148 51684 2619 9439 10284 374654 2736 6497 1387 6383 7531 4086 2735 25942 1859 1499 50937 91653 50846 6469 409 64399 6608 5727 8643 3549 PMC4968084__F3 Unlike the 20S proteasome, the subunits of the Immunoproteasome lack functional EpRE binding domains, and so cannot be regulated by Nrf2 3458 3716 3717 6772 PMC4968756__F7 Model for p53-mediated resolution of replication barriers 11201 56852 6596 84083 4361 PMC4969253__F1 Retinoid regulation of early lung development 2255 22943 59 4629 6722 PMC4970609__F10 Roles of hBVR in activating IRK/PI3K/Akt pathway 3479 5163 207 2931 571 PMC4972100__F1 The serine synthesis pathway and downstream anabolic reactions of serine 26227 29968 5723 PMC4975441__F4 Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells 2056 2057 3717 9021 PMC4975441__F8 Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells 2056 2057 3717 9021 PMC4976833__F1 Cell density regulates cancer metastasis via the Hippo pathway 154796 4485 60485 26524 81532 PMC4980033__F3 Modelling the Structure and Dynamics of Biological Pathways 3098 2821 8021 55706 9883 7175 PMC4981705__F1 PI3K/Akt/mTOR signaling pathway and the existing molecular targets for therapy, which was indicated by ∆ 3667 5728 7249 7248 5163 9675 2475 6009 64798 253260 64223 PMC4982223__F1 Signaling network of drug-induced glioma differentiation 3717 6774 595 2670 PMC4983472__F5 Intracellular and intercellular signaling and cellular dynamics in bone healing and bone remodeling 650 4087 4088 1499 4090 4086 860 9242 5741 PMC4988449__F1 Schematic model depicting how ERK1/2 activity is transduced through the Shoc2 scaffold 55914 5480 23513 5705 158401 8036 PMC4988654__F1 Major steps in the retinol signaling pathway of vertebrates 157506 8854 3198 9249 PMC4990112__F3 RNF8 and RNF168 promote the accumulation of 53BP1 and RAP80 at DSB sites 7316 9025 3014 165918 26013 672 137735 PMC4991353__F2 Canonical and non-canonical Wnt pathways have differing effects in cancer 324 1499 382 4040 4041 4920 PMC4993636__F4 Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network 6010 154796 8994 847 6714 3611 PMC4996367__F1 Immune cell-derived complement on T cell immune responses 114548 4179 718 727 940 4965 920 958 942 324 PMC5002928__F3 Overlapping RAS/MAPK and PIK3CA/AKT/mTOR signaling pathways and potential therapeutic targets 100187907 6654 2885 4763 673 2475 7249 7248 PMC5005280__F3 Core Hippo pathway 4771 9113 7003 8463 7004 7005 PMC5006112__F1 MTOR pathway 1956 253260 2475 5728 7249 7248 6794 5228 PMC5010719__F1 MET signaling pathway in IPF 5290 2885 2549 3845 PMC5020118__F1 Innate immune dysfunction in rosacea 7097 2247 7442 8989 25818 PMC5025790__F9 Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency 1499 1601 4087 79923 6997 5175 4086 4089 4090 4088 4838 PMC5027901__F1 Listeria monocytogenes and the inflammasome: from cytosolic bacteriolysis to tumor immunotherapy 4942 3654 9447 834 PMC5028879__F1 NOD2 senses MDP and elicits immune responses 55054 8767 64127 7189 PMC5031174__F7 Diagram showing the regulation of dopaminergic neuronal differentiation of human neural stem cells (hNSCs) 3667 5728 2475 PMC5031610__F1 Current knowledge on the cell type/context-dependent regulation of NFKB signaling by Wnt/Beta-catenin pathway 7099 55504 324 8945 PMC5033717__F1 Dll4-Notch Signaling in Macrophage Activation 4855 4853 4851 4854 3516 PMC5038578__F1 Molecular pathways associated with inflammatory bowel disease 85480 7099 7494 9231 1893 149233 3593 6774 3717 1235 64170 64127 345611 55054 3663 120892 5771 7128 114548 8807 3586 10109 55600 6584 1755 5734 PMC5041942__F2 Dissecting dysfunctional crosstalk pathways regulated by miRNAs during glioma progression 7422 5499 57819 PMC5045229__F4 Cabozantinib provides dual inhibition of MET and VEGFR2 preventing the MET pathway from acting as an alternative pathway in the development of VEGF TKI resistance 3082 2475 4193 572 PMC5045435__F2 Notch signaling: its roles and therapeutic potential in hematological malignancies 4851 4853 4855 4854 PMC5056326__F1 Epidermal growth factor receptor signaling along with co-activated other receptor tyrosine kinases 1956 5728 3845 5290 673 2475 PMC5056326__F2 Possible resistance pathways to epidermal growth factor receptor blockade; gain of mutations in KRAS, BRAF, and PIK3CA and upregulation of other receptor tyrosine kinases 1956 5728 5266 3845 673 2475 PMC5069789__F2 Epigenetic mechanisms mediate DEP effects on asthma pathogenesis 7039 1956 405 3091 196 3606 3569 85480 6364 1543 4851 PMC5070052__F4 Schematic presentation of how the rs17228616 single-nucleotide polymorphism (SNP) in the acetylcholinesterase (AChE) gene may affect the vulnerability to stress 998 693193 43 PMC5070725__F1 Schematic model of metabolic regulation by S6K1 in two ways 7249 7248 7475 80326 7480 2146 PMC5072394__F1 Viral evasion of intracellular DNA and RNA sensing 5478 7706 57506 3665 3661 PMC5073228__F2 Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping 252842 4191 114569 262 PMC5075921__F4 Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data 3552 3479 7039 6885 4214 101180900 PMC5078498__F1 Dopaminergic miRNA nodes in a rich network of connections in synaptic plasticity pathways 51422 5567 11261 PMC5081350__F1 Wnt/Beta-catenin signaling pathway 999 4041 4040 8658 2932 324 607 PMC5082882__F1 Estrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERA in Breast Cancer Cells 9415 60481 3992 54898 PMC5084369__F5 PHBHHx synthesis pathway with R-specific enoyl-CoA hydratase 717 286205 729 PMC5086583__F1 Immune effector cells induce tumor cell death through apoptosis and necrotic-like cell lysis 355 8772 11035 8737 637 197259 PMC5089367__F5 Targeted interactome of microRNAs (miRs) (miR-30c and miR-331-3p) 2932 25 868 8660 PMC5095004__F9 MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma 406913 8408 355 2475 4118 PMC5095497__F7 Role of the citrate pathway in Down syndrome (DS) 47 788 23152 PMC5097370__F4 Regulation of myofibroblast formation by TGFB1 7939 4087 4088 4089 3725 PMC5098220__F1 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks 1795 2534 4690 10048 140885 55816 4915 5781 10817 7189 10818 8440 10603 6272 23373 4804 2885 5879 2891 7074 5515 5296 627 5295 23426 1385 1363 2562 PMC5098220__F2 Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks 2908 861 672 25803 994 4193 5881 3572 5296 3725 2934 3065 2068 2965 5295 5925 6736 1386 1022 1387 2966 56924 902 367 7182 5829 1385 898 6667 23132 984 3303 8554 5901 2119 896 10048 6714 993 1956 9063 3276 10499 64324 2308 2099 8204 PMC5103945__F1 STRING analysis of metabolic and PI3K-Akt signalling pathways 5037 1808 2316 801 283298 10971 3881 7277 7529 347733 633 5660 203068 5339 7430 7317 7431 6206 81 7123 5176 2950 3190 5315 4191 7167 2194 5093 3105 259 2180 10226 PMC5104533__F2 An Immunological Perspective on Neonatal Sepsis 5978 95 6778 3553 PMC5107467__F7 Amide-linked local anesthetics induce apoptosis through apoptotic pathways (the extrinsic death receptor pathway and the intrinsic mitochondrial pathway) and MAPK pathways in human non-small-cell lung cancer cells 8772 595 581 331 PMC5116300__F2 Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease 5226 4049 4050 3565 PMC5118085__F1 Notch signaling and alloreactivity 102 4855 4853 4851 4854 PMC5120243__F4 Network model for CTNNB1 999 1499 6657 2932 4609 8312 324 PMC5125391__F2 Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells 3065 3066 27113 8841 581 2932 PMC5127718__F2 Endocytic Pathway in Microglia During Health, Aging and Alzheimer’s Disease 6009 28962 4074 4286 7942 PMC5129989__F6 Higher methylation intensity induced by EBV LMP1 via NFKB/DNMT3b signaling contributes to silencing of PTEN gene 3550 7186 5728 PMC5138100__F6 New Insights into Protein Hydroxylation and Its Important Role in Human Diseases 2057 5597 54101 10075 PMC5139348__F2 PI3K Pathway in B Cell Metabolism 3939 355 47 PMC5142754__F1 Targeting Inflammation in Cancer Prevention and Therapy 920 3479 6347 6774 PMC5145311__F2 NLRP3, NLRC5, NLRP7, AIM2 and other inflammasome-like signaling is activated in response to S 4049 7097 1508 114548 9447 199713 84166 PMC5145761__F3 Displays canonical BMP pathway identified through Ingenuity Pathway Analysis (IPA) 9241 10468 8646 26585 2885 331 4090 4086 57154 4089 814 860 3224 5308 4092 1482 3196 PMC514949__F9 Multiple pathways involved in tumorigenesis by VEGF-null tumor cells 5091 5155 5159 PMC5149521__F3 PKB associated signal transduction pathways 5163 2475 4193 2932 572 1977 790 PMC5161652__F7 Signaling events leading to MYC and YAP upregulation 3845 2475 4609 PMC5161754__F7 EGFR activation during CRC progression through demethylation and subsequent upregulation of EREG at the adenoma–carcinoma transition 1956 324 3845 2069 PMC5167405__F8 Non-Canonical Role of IKKA in the Regulation of STAT1 Phosphorylation in Antiviral Signaling 57506 6772 29110 3661 3569 7297 3716 PMC517537__F7 Signaling kinases involved in regulation of TNFA, IL-10, and IL-6 in Kupffer cells 4049 3717 6714 PMC5179308__F7 Pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease 4087 4088 6774 2191 PMC5179564__F7 Acetylation of central metabolic enzymes in desiccated embryos 31 2194 355 3073 8772 51 34 33 37 3033 PMC5187684__F1 A schematic of metabolic intermediate labeling from 13C glutamine 23530 3417 3418 PMC5192018__F3 Pubertal development and regulation 3814 2798 3479 PMC5209547__F1 Quantification of thalamocortical dynamics using natural and artificial paired-pulse paradigm 4397 6786 57620 PMC5221490__F6 Intrinsic and extrinsic factors used during vertebrate lens development 182 90 4040 4041 2885 4090 4086 4089 324 1499 2475 3516 3280 5629 5080 6656 5309 2301 6657 PMC5226473__F1 CDK4/6 inhibition: the late harvest cycle begins 1019 1956 7249 6009 2475 PMC5228523__F4 MicroRNA-gene interaction networks of the MAPK signaling pathway 1432 1399 8491 5597 355 79109 645121 613 3845 775 5894 9448 1147 1844 783 5604 1398 898 4293 5921 1870 2152 PMC5238783__F2 miR-22 services as onco-miRNA to promote tumor malignant transformation 5728 894 5594 PMC5240418__F1 The notch signalling pathway in prostate cancer 28514 4851 23462 PMC5241319__F2 Autocrine and intracellular complement activation 4179 718 727 940 1514 114548 2475 3553 PMC5241746__F10 Working model 2066 4851 1956 PMC5243832__F1 Activation and regulation of complement pathways relevant to Borrelia spp 717 716 966 721 720 735 4155 5648 2271 PMC5255577__F7 Proposed model for the role of GAS6 in maintaining oral mucosal homeostasis 2621 27035 50506 4615 6965 50943 PMC5256872__F7 Transcriptome Sequencing Reveals Key Pathways and Genes Associated with Cisplatin Resistance in Lung Adenocarcinoma A549 Cells 2258 2261 84699 2257 5606 5608 3678 387 10398 6093 623 2245 3985 9475 PMC5260980__F4 Signaling pathways at the crossroad between autophagy and EMT 6714 6774 5610 860 1869 2475 9191 PMC5267352__F1 Reviving the promise of transcription factor Nrf2 based therapeutics for kidney diseases 1728 9817 2944 7086 957 PMC5270455__F14 Directional pathway satisfying TIM of Table 208 7048 1956 5693 3065 PMC5270455__F15 Directional pathway satisfying TIM of Table 208 5693 1956 7048 3065 PMC5270455__F4 Pathway derived from perturbation experiments 1956 10014 1017 5894 5693 1909 3480 5159 2260 PMC5271588__F6 Cross-talk between apoptotic pathways 8772 637 581 PMC5272809__F1 New View into the Regulation of Purine Metabolism – The Purinosome 5471 2618 10606 7808 158 471 8833 PMC5279777__F3 Transcriptome Analysis Reveals Comprehensive Insights into the Early Immune Response of Large Yellow Croaker (Larimichthys crocea) Induced by Trivalent Bacterial Vaccine 22861 114548 51135 387 7189 23118 6351 PMC5283709__F3 A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2 5979 717 2444 7015 847 PMC5288595__F2 Steroid-specific protein markers 338 348 173 2641 715 2908 57142 3630 7124 3381 2247 4240 2690 8404 332 7049 5069 PMC5288595__F5 Serum markers that change in response to treatment 1270 5034 3484 2908 7124 948 3485 3440 4684 5265 56729 183 PMC5289082__F5 Toll-like receptor-mediated actions 4615 7187 7189 3661 5163 PMC5291771__F1 The signaling pathway of DDX41 in innate immunity 6737 51428 695 29110 3661 PMC5295004__F8 Proposed model of selected miRNA action on the regulatory T cell pathway 4090 50943 864 940 1493 PMC5295401__F5 Anti-cancer effects of nitrogen-containing bisphosphonates on human cancer cells 2339 2342 5876 5875 PMC5295594__F2 Regulation of ecdysteroidogenesis 4087 7248 7249 PMC5296735__F5 Integrated Analysis of LncRNA-mRNA Co-Expression Profiles in Patients with Moyamoya Disease 2353 604 7506 3577 3579 1438 1441 58191 PMC5307469__F7 Role of ATF5 in the survival of B cells during stress 468 3651 22809 PMC5310573__F5 Estrogen metabolism pathway including enzymes (blue field) and chemical compounds 3294 3295 3283 412 1588 3292 3293 51478 3028 PMC5315647__F7 Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis 5443 4157 4286 545 7507 PMC5315647__F9 Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis 434 545 7507 PMC5323256__F8 Glycogen Synthase Kinase-3B Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3 4803 3479 2932 PMC5329892__F3 WNK kinases in development and disease 1638 130497 324 1499 PMC5330258__F1 VD3 is metabolized to 25(OH)D3 and 1,25(OH)2D3 by the classical pathway or to 20S(OH)D3 and 20S,23(OH)2D3 by CYP11A1 1583 120227 1593 1594 PMC5334258__F3 Trafficking pathways of E-cadherin 999 7792 6642 115677 55737 23513 PMC5338674__F7 Model for Pol E function in plant DDR 545 7465 472 5888 4549 6052 672 10038 PMC5341791__F3 Signaling pathways triggered by GDNF activation of the RET transmembrane receptor 2668 2674 5979 2885 6714 4613 2119 2353 255877 PMC5342467__F9 RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation 9628 1786 55929 472 PMC5343289__F2 Crosstalk between autophagy and inflammatory signaling pathways: balancing host defence and homeostasis 3458 3553 4615 3716 3717 6774 55054 115004 114548 8408 57506 7284 79671 83939 29110 PMC5343750__F1 Are Circulating MicroRNAs Peripheral Biomarkers for Alzheimer’s Disease? 5901 29102 27161 PMC5343756__F1 A Critical Evaluation of Neuroprotective and Neurodegenerative MicroRNAs in Alzheimer’s Disease 29102 5901 27161 PMC5345629__F5 Validation and interaction networks of the differentially expressed miRNAs 100616362 6651 100422898 100422903 PMC5346041__F1 Major pattern recognition receptors (PRRs) that sense RNA and DNA virus pathogen associated molecular patterns (PAMPs) in the cytosol 115004 7706 9447 57506 10013 3661 3428 PMC5346233__F2 Targeting Notch signalling pathway regulates angiogenesis in the pathological ovary 4855 4853 4851 4854 PMC5349796__F7 E2 and CTNNB1 signals in the oviductal ciliated and secretory epithelial cells regulating embryo transport 2099 1499 64147 2302 2100 PMC5350184__F2 Genes involved in adipose tissue TLR‐ and insulin receptor signaling correlated with changes in plasma concentration of fetuin‐A and FFAs 983 4791 6416 1520 7098 81793 9641 7529 10333 10312 10695 7097 7867 4214 64127 30849 148022 2885 5295 7248 53358 114609 64223 257397 92335 81622 3265 8517 59307 353376 5606 PMC5354754__F1 Novel non-canonical Wnt signature for prostate cancer aggressiveness 2535 2534 3725 PMC5354803__F3 Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis 5465 4193 1718 619501 595 1499 4513 PMC5356782__F1 Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors 5728 4193 572 2475 595 PMC5356782__F2 Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors 5728 2475 4193 572 595 PMC5356817__F5 Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm 3937 920 10261 4638 10398 7096 2213 714 944 72 1075 5592 6093 148 9450 9473 1674 4629 929 7169 8736 3689 1535 199 9499 PMC5364541__F8 Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway 10379 4938 4939 4940 6773 6772 PMC5365060__F3 Biosynthesis of high-carbon sugar nucleoside antibiotics 5423 5429 51426 4937 5428 11201 PMC5366100__F2 Regulation of NOX by H 50506 27035 5879 10811 405753 4693 8775 PMC5366789__F1 Suggested signaling pathways for induction of the immunosuppressive catabolic enzyme indoleamine 2,3-dioxygenase (IDO1) in vertebrate dendritic cells (DCs) 958 7186 7189 7187 4087 4089 4088 942 941 PMC5368180__F1 Nanotechnology-based therapy for prostate cancer 1499 8000 960 PMC5370073__F1 Impact of CTLA-4 Ig versus anti-CD28 domain Abs on alloreactive T cell responses 940 7124 941 942 324 PMC5371856__F1 Outer membrane protein-mediated pathogenesis 7124 1956 84002 PMC5371895__F1 Schematic metabolic model showing important pathways after proliferation of Streptococcus suis serotype 2 in porcine blood (A) and cerebrospinal fluid (CSF) (B) 5805 51083 11113 PMC5373476__F7 Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis 4280 3569 9021 PMC5374451__F3 Molecular signaling involved in nephrogenesis 80144 1499 3237 2625 655 652 6495 10736 51804 2138 5979 147912 6299 54361 5914 7490 10371 2296 6092 10252 9353 4010 2668 PMC5378159__F1 Synthesis and metabolism of repressors of SREBP processing and LXR ligands, 24S,25-EC, 25-HC, of the EBI2 ligand 7A,25-diHC and of the RORGt ligand 7B,26-diHC 1581 10858 9023 9420 3290 1593 133688 100188864 PMC5385204__F6 Genomic alterations in malignant melanoma 4254 4803 4804 673 10000 2475 4609 434 3106 4157 2778 5566 2146 2932 4193 468 7157 666 10397 2033 64764 7020 PMC5398979__F2 Pathway alterations in glioblastoma 5156 1956 5728 4763 673 1029 1031 4193 1030 4194 7157 1019 1021 5925 PMC5400530__F1 Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old 7040 4018 351 51084 202559 3240 348 341 3077 335 9370 324 5468 4547 1071 338 PMC5400641__F8 MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1 331 56616 4170 PMC5404519__F1 Biosynthetic pathway of the major phospholipids in bacteria 5662 283871 716 PMC5406167__F6 Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster 10664 84164 57649 10066 27304 26278 221443 29100 PMC5410324__F1 PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases 1956 5266 673 PMC5413166__F5 An example of innate immune response induced by E2 in ML-1 cells 259217 23764 26278 920 64840 6297 950 259266 6955 1537 58191 5669 PMC5415012__F1 Schematic representations of selected modes of cross-talk between autophagy and the secretory pathway 8408 9706 9871 9919 9895 PMC5416959__F10 RFC-PCNA complex inhibiting cell proliferation 5983 6256 5984 5982 5985 5981 5111 PMC5420131__F1 Canonical Wnt/Beta-catenin pathway: “WNT ON state”: WNT proteins, by binding to frizzled receptors and the LRP co-receptor, act to suppress the activity of glycogen synthase kinase-3B (GSK-3B) 84133 2932 1499 7008 PMC5422340__F3 P53-mediated regulatory network via Ingenuity pathway analysis 7157 7124 2064 4792 6774 6667 1051 1052 3725 2908 2099 2353 2309 1499 5970 PMC5423040__F2 Hunger-satiety circuit and energy balance 4160 23237 4852 181 5443 3953 2693 3643 5697 PMC5423755__F1 FA/BRCA DNA damage response pathway 83990 7516 5889 675 79728 5888 2072 7398 PMC5426649__F8 Hypothetical model for IGF-I regulation of kitlga expression and its signaling mechanisms in the zebrafish follicle cells 5163 1956 1950 PMC5433029__F1 Hypothetical schematic of the physiological and pathophysiological roles of Notch signalling in articular cartilage 3516 100188776 4851 4853 182 102 4322 11096 9173 PMC5435544__F4a Signal transduction pathways and targets in paediatric Burkitt lymphoma 941 3654 3455 351 3454 7189 51135 3551 4792 6885 5604 5600 6772 356 3552 7132 5894 9448 5601 9261 7867 PMC5436606__F1 PD-1 and CTLA4: Two checkpoints, one pathway? 324 3932 940 PMC5437908__F2 Predicted synthesis pathway for the t6A modification and its derivatives in H 79693 84520 4553 51531 54901 PMC5437952__F3 Cholesterol metabolism controls plasmacytoid dendritic cell (PDC) innate functions 7436 3949 51284 54106 3717 3665 2194 9619 3569 19 7124 PMC5441870__F3 Central metabolism of T 3033 8634 8775 4693 PMC5447936__F2 AUTS2-Rac signaling pathways in neuronal migration and neuritogenesis 26053 63916 1356 5879 PMC544835__F1 Reverse Cholesterol Transport 335 19 3931 338 3949 1071 PMC5449392__F6 Proposed role of ARRB1, CALM3, FLNA and HTT in OSCC 408 5900 808 5898 2316 7204 5879 3064 PMC5449464__F4 Signaling and crosstalk associated with relaxin activation of its receptor RXFP1 59350 4842 2638 PMC5449640__F5 Hypothetical driver pathways for BRCA carcinogenesis and progression 675 472 5888 841 999 1499 355 5290 207 7157 5295 3443 7148 4018 2064 1027 2263 2625 1432 2261 4214 3845 6416 4763 8289 PMC5452883__F1 Intratumoral synthesis of E2 and its inactivation by sulfate conjugation from circulating steroid hormone precursors in cancer cells 6783 3294 3292 412 PMC5453110__F1 IL-8/IL-8R axis 1499 6850 6714 3579 3577 5728 6935 1386 PMC5454446__F2 ‘Eat-me' signals, phagocytic machinery and signaling pathways 2621 10461 84466 55576 51454 5879 PMC5457688__F4 Précis of signaling pathways involved in glioma and inhibition by mTOR, AKT, PI3K and ERK inhibitors and genetic configuration of TSC1 and TSC2 5163 5728 2475 7248 7249 6009 1977 PMC545806__F7 Different pathways use the RecQ helicase in response to replication stalling 4360 5888 118027463 PMC5458287__F1 Targeting HOX/PBX dimers in cancer 1956 841 637 581 467 836 PMC5462947__F4 Metabolic traits of KF-JG30-18 (A) and DA052 (B) as derived from the genetic potential of RH2 MAG 17b and RH1 MAG20 4118 5817 11113 11019 140805 4099 PMC5464940__F1 MOA of CHST15/CS-E and STNM01 in tissue remodeling in IBD 51363 6347 1499 PMC5466160__F1 Autophagy pathway 8408 23192 64422 10533 9140 83734 9474 PMC5466881__F1 Strategies for Increasing Pancreatic Tumor Immunogenicity 6347 958 920 10563 2669 PMC5468379__F1 Viral RNA detection by RLRs and TLRs, signaling pathways and overview of FMDV strategies aimed at its supression 3454 3455 7297 51311 51284 7098 6772 6773 57506 10010 29110 3661 PMC5471068__F2 Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse 2057 5879 4088 4193 2475 3717 6774 4609 4092 PMC5472345__F1 The NAD+ salvage pathway and its control by the circadian clock 23411 406 2308 10135 6774 4808 9575 PMC5474195__F2 Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy 5728 5163 6009 1499 1977 PMC5476263__F2 Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes 472 2237 545 55215 2177 641 9156 22909 6596 PMC5480029__F1 Sulfide (S2−) homeostasis and small-molecule chemistry that couples reactive sulfur species (RSS) and reactive nitrogen species (RNS) 3988 2242 875 140821 PMC5480057__F4 Extended regulatory network to describe Nanog multistable dynamics in serum/LIF 6657 2250 79923 2103 9314 2249 PMC5480880__F6 Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies 5728 3845 286204 2885 673 284656 2045 831 2064 2065 PMC5482757__F2 Emerging Role of MicroRNAs in mTOR Signaling 5728 627 27250 54541 7248 7249 6009 PMC5483877__F1 Strategies of effective targeting of hepatocyte growth factor (HGF)/c-Met signaling for the prevention of hepatocellular carcinoma (HCC) 3082 23163 5266 619501 PMC5485509__F2 Histone modifications regulate gene transcription involving renal fibrosis of diabetic kidney disease 11091 4087 4088 PMC5486002__F1 The human 42 Kb INK4-ARF (CDKN2A/B) locus (not to scale) and its participation in two pathways controlling cell-cycling and differentiation 4193 1021 1019 1869 PMC5486146__F1 Thyroid cancer hystotypes and their causative genetic events 7849 673 5728 7157 1499 PMC5488238__F6 BMP–Notch interaction in intestinal homeostasis and CRC disease subtypes 652 650 659 3399 3397 3398 100188776 9794 PMC5488350__F1 The Taste of Caffeine 5330 29850 3710 255022 PMC5488809__F2 Cancer metabolism as a central driving force of glioma pathogenesis 5290 7015 5728 7157 546 PMC5490254__F2 WNT and SHH signaling pathways 6469 6608 324 847 PMC5490603__F2 Pro-inflammatory signaling pathway influences by zinc 3654 3656 7189 4615 3717 6774 50943 8717 PMC5490603__F3 Anti-inflammatory signaling pathways influenced by free zinc 3559 3716 3718 55872 5728 6778 4087 4088 4086 4090 4089 PMC5492138__F5 Mechanism of encoding the NSC modules 25801 2641 2548 PMC5492501__F3 N-myristoyltransferase functions during T cell activation 324 59330 920 7535 5335 4082 3932 90550 2353 27040 PMC5495464__F3 Interactions of IGF and ERB signaling pathways in malignancy 3482 3479 3481 1950 3480 1956 3667 2475 6774 PMC5496785__F1 Restore the brake on tumor progression 6469 6608 5727 2735 2736 2737 PMC5497685__F1 Ca2+ regulates different steps of autophagy 759 5266 2475 8408 7942 7226 PMC5501176__F3 Roles of SIRT1 signaling pathway in cancer in type 2 diabetes 7422 6794 2475 23411 10891 3065 472 4790 PMC5501640__F1 Sketch of Hedgehog (Hh) signaling pathway 6608 2737 2736 2932 51684 91653 PMC5501692__F3 Human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion 8870 8061 4609 1958 2115 2118 2119 595 2353 10253 1846 1848 81848 PMC5501721__F1 Extracellular nutrients are required to maintain oncogenic signaling in brain cancer – a critical role for mTORC2 5290 5728 7018 PMC5501910__F3 Rescuing the BMPRII signaling pathway in pulmonary arterial hypertension 4089 4090 4086 PMC5503689__F2 Inflammasome complexes: emerging mechanisms and effector functions 7099 115004 9447 3553 PMC5508477__F6 Representative scheme of the mechanisms involved in the induction of cell cycle arrest and senescence.MPM cell lines are frequently deleted in CDKN2A/ARF gene, coding for both p16INK4a and p14ARF 1021 1019 4193 4609 PMC5510550__F1 Negative Regulation of Type 2 Immunity 64806 90865 85480 PMC5511860__F6 BMP-2 induced EMT and breast cancer stemness through Rb and CD44 signaling 650 4086 960 PMC5512163__F2 Biologic and Clinical Perspectives on Thyroid Cancer 673 6886 5979 4914 4916 2475 PMC5513686__F1 Principal effects of chronic alcohol abuse on anabolic and catabolic mechanisms that maintain skeletal muscle mass 3479 3667 2475 PMC5514982__F1 Caloric restriction, exercise and AdipoR pathway activate AMPK–SIRT1 and PPAR pathways, which may increase longevity in humans 4280 23411 2475 PMC5520166__F3 Regulatory role of ubiquitin on RIP1 and RIP3-dependent cell death 7124 9001 1540 81858 8717 197259 PMC5524291__F9 An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation 3662 596 604 595 PMC5524462__F2 PD-1 is also expressed on T-cells following TCR engagement and activation 324 2475 10538 PMC5525309__F1 Innate immunity 324 920 54106 51311 7097 51284 5066 1445 7099 7098 7096 PMC5525309__F6 Working model of metabolic risk factor-induced two-way stimulatory immune checkpoint amplification and systemic/tissue inflammation 6774 324 958 4023 PMC5527962__F4 Cell adhesion pathway and ECM–receptor interaction pathways are affected by RCT 100506658 960 255743 1101 948 58494 90952 1003 4267 961 PMC5528795__F6 Working model of pyrithione zinc in oral cancer 572 581 2475 253260 595 PMC5530473__F1 Considering the spectrum of colorectal cancer (CRC)—conventional adenomas progress by the sequential accumulation of genetic mutations and chromosomal instability causing microsatellite stable (MSS) tumours 2191 673 324 3845 1499 4436 2956 4292 27030 5395 5378 4255 4089 PMC5531345__F7 Scheme of the pathway mediating the VEGF-induced disassembly of adherence junctions and its regulation by NDPK-B 1003 1499 857 PMC5538798__F10 Schematic diagram summarized as a possible mechanism of action of melamine causing tubular cell injury via CSR-mediated Ca2+signaling pathway 4199 581 7040 PMC5539260__F7 Overview of the pathogenic model of C. difficile infection 114614 51435 6850 4179 2335 79400 1956 5966 PMC5541263__F8 Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway 54790 8650 6256 5915 PMC5546324__F5a AKT/PKB Signaling: Navigating the Network 7249 8161 51256 6009 PMC5546706__F4 Reconstructing the regulatory circuit of cell fate determination in yeast mating response 729 717 718 727 84188 PMC5548460__F1 Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape 3717 10419 4005 PMC5549471__F2 HN inhibits OS and ER stress in RPE by direct and indirect mechanisms 468 6774 83939 PMC5552414__F7 Abl Kinase Regulation by BRAF/ERK and Cooperation with Akt in Melanoma 6774 5728 7291 6935 4286 PMC5552450__F6 Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis 26227 29968 5723 PMC5552660__F1 Cholinergic anti-inflammatory pathway (CAP) 4922 920 7124 PMC5554756__F3 Negative regulators of the RIG-I-like receptor signaling pathway 9958 2146 57506 7105 5347 79671 7187 54941 64750 3661 PMC555938__F5 Pathway of circadian regulatory system of Arabidopsis thaliana according to the dynamic regulatory modeling in Table 1 1407 1408 1999 878 PMC555938__F7 Pathway of circadian regulatory system of Arabidopsis thaliana in Fig 1407 1408 1999 878 PMC5559826__F2 Downregulated genes involved in the insulin signaling pathway in response to the sugar-only diet 355 5447 572 9365 PMC5562928__F1 Amino acid synthesis in I 5053 1491 875 26227 29968 191 4397 374569 64902 5831 4942 PMC5567665__F1 Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans 4190 4191 48 50 3417 3418 PMC5568011__F7 MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis 3643 5770 6667 3667 PMC5568901__F1 Antiviral mechanisms in mammalian cells: IFN-based antiviral system, including IFN expression pathway (AE) and IFN response pathway (AR); the intrinsic antiviral pathway (B); and the RNAi antiviral pathway (C) 6041 6035 7098 115004 3716 7297 PMC5569249__F2 miRNA pathways in mature immune cell function 8651 4615 3654 3656 3553 PMC5569936__F7 Metabolic control involved in aging and on the cardiovascular system 3479 2475 7039 5155 PMC5571822__F1 EGFR pathway and mechanism of action of osimertinib.Abbreviation: EGFR, epidermal growth factor receptor; TGF, transforming growth factor 7039 1950 3716 3717 6774 2475 PMC5576761__F4 High activity of immune response 2632 6348 3001 356 5551 3458 8320 10563 4174 1870 8318 79019 11130 5685 64785 220134 10762 63826 51003 23511 10036 29968 PMC5578810__F2a Fanconi Anemia Protein Interaction Network: Casting A Wide Net 51455 1196 84126 545 5111 PMC5581236__F7 SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling 54567 4851 7341 29843 23493 23462 3280 PMC5582844__F7 Proposed model depicting cross-talk between Gq-coupled GPCRs and CLEC-2 pathways 7175 6850 1845 5336 PMC5584733__F3 Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms 9986 5879 3652 PMC5586499__F1 Metabolic Abnormalities and Oxidative Stress in Lupus 5079 10320 7187 2475 PMC5589692__F6 P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells 7422 2534 998 9261 3984 PMC5593528__F8 Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway 1021 1019 7019 PMC5594453__F3 Signaling pathways that are activated by TMEM16A in cancer 1950 1956 6714 PMC5595361__F1 Signaling pathways involved in GBM-induced apoptosis 7124 355 581 PMC5595793__F1 Schematics of alcohol production via the iterative ketoacid elongation 718 727 729 730 PMC5597960__F7 Systemic lupus erythematosus (SLE)-activated platelets induce endothelial cell activation via an interleukin-1B (IL-1B) pathway 4018 3553 3383 PMC5600322__F2 HSC Niche Biology and HSC Expansion Ex Vivo 3091 4211 7173 3939 PMC5601171__F3 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy 6469 6608 2475 2736 2737 5727 2305 9429 6657 10399 2735 2717 PMC5601171__F5 Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy 6608 1950 1956 5727 2735 60674 5728 2475 4609 PMC5603960__F2 Biosynthesis of azaphilone pigments in Monascus fungi 4548 3009 3024 PMC5604037__F6 Schematic overview of MYC-mediated metabolic pathways 5634 790 1723 4975 5471 2618 5198 7808 10606 4311 158 8833 1719 22934 2821 7298 4548 5213 100188776 4524 3945 10797 PMC5604128__F3 Extracellular matrix-receptor interaction signaling pathway 960 7450 1101 952 961 PMC5606087__F8 Connection among hub genes predicted on KEGG pathways 5566 7046 154796 7532 7529 PMC5614325__F2 SASP regulation 472 4851 23476 2475 PMC5623058__F5 Lipid metabolism regulatory network proposed for the breast of female chickens at hatching, based on significant DEGs and KEGG pathway analysis 6469 3953 5468 PMC5624635__F1 MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response 472 545 4193 1869 PMC5626595__F2 ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES 3454 3455 23352 6772 6773 373 115004 57506 5184 9636 4599 10379 3661 3665 PMC5629629__F8 Proposed model of the cell autophagy induced by SAHA and TRAIL DR5-CTSB in breast cancer cell lines 1508 2475 23192 PMC5630445__F3 The role of toll-like receptor 4 in tumor microenvironment 3553 7099 929 PMC5632348__F6 Schematic illustration of the TLR4 signaling pathway (a) and inhibition via TAK-242 (b) 7099 114609 4615 3661 PMC5635916__F6 Model for how cytosine deamination, base excision repair, and Mlh1-Mlh3 cleavage cooperate to cause R-loop–induced CAG repeat fragility and contractions 4292 27030 9156 5810 PMC5640981__F3 Thyroid C-Cell Biology and Oncogenic Transformation 5163 2885 6464 2549 7249 7248 572 6009 842 PMC5641208__F1 S100A4 in cancer progression and metastasis: A systematic review 1499 324 2475 6275 3927 4041 PMC5642638__F2 Role of PLZF as a tumor suppressor in prostate cancer 1950 367 2309 3845 9622 673 5087 PMC5642988__F2 The Hippo pathway in intestinal regeneration and disease 4478 898 1956 PMC5646231__F1 Regulation of Exercise-Induced Autophagy in Skeletal Muscle 664 139341 2475 8408 9706 65018 PMC5649010__F8 Model for atypical MyD88-independent TLR7 signaling during Yersinia pestis infection 8411 3916 51284 4615 PMC5649202__F2 Gene regulatory network (GRN) inferred for members from the NFKB pathway 5584 29775 6955 29760 472 1147 6850 PMC5650456__F1 Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma 3902 7039 4803 1950 3815 634 942 941 1956 4893 673 596 4286 PMC5650460__F1 Dual roles of yes-associated protein (YAP) in colorectal cancer 2475 1956 6469 PMC5652078__F2 HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles 2625 2475 1021 1019 PMC5653149__F1 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer 1950 3045 100187828 6678 PMC5653149__F15 Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer 5699 4843 28232 348 5743 5480 10628 PMC5657420__F1 Classical pRb pathway demonstrates the utility of CDK inhibitors, such as palbociclib, in RB+/+ osteosarcoma 1021 1019 1017 PMC5659022__F2 Proposed scheme for the role of BMSCs in modulation of p53-miRNA interaction in association with stroma-induced drug resistance in MM 7157 3569 406911 581 1026 PMC5659038__F5 Relationship between lipids and hedgehog signaling 6469 6608 10645 7289 23432 PMC5660951__F7 Suggested mechanism of EtSCT action in CCl4-induced hepatic injury 581 4087 4088 4313 4318 PMC5663622__F3 Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials 2147 324 1499 6010 PMC5678957__F1 Cell biology of APOL1 7942 8542 6774 PMC5682975__F5 Proposed model of IRAK4 regulation of TLR7/8 signaling pathway in human monocytes is shown 51284 4615 51135 7189 3663 7124 3569 PMC5697091__F10 List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C 2161 718 2152 2160 7450 2157 7035 2159 2 1431 727 1380 729 1361 735 2147 730 PMC5705551__F1 Major in vivo approaches for tolerance induction and suppression of inhibitor formation in hemophilia 324 941 942 2475 5132 7939 50943 920 613 PMC5705586__F3 Fibroblast Growth Factor 2 as an Antifibrotic: Antagonism of Myofibroblast Differentiation and Suppression of Pro-Fibrotic Gene Expression 7046 4087 4088 4092 4089 PMC5707548__F1 ATM (ataxia telangiectasia mutated)-mediated DDR (DNA damage response) signaling pathway 472 9656 3014 165918 672 9025 PMC5709539__F1 Emerging mechanisms underlying astrogenesis in the developing mammalian brain 1499 4762 2670 PMC5712004__F3 Model depicting targets of CHOP-dependent apoptosis 83939 581 8772 PMC5715373__F1 Strategies to generate tolDCs for clinical therapeutics 940 941 942 958 355 PMC5715847__F3 Wnt‐cGMP/Ca2+pathway 998 51701 1499 PMC5715866__F6 Schematic showing the roles of EGFR ligands and NRG1 in the regulation of timing of ovulation and oocyte maturation 2065 374 3084 2069 685 1956 PMC5719056__F1 The mevalonate pathway leads to cholesterol synthesis 3156 2224 2222 PMC5721403__F1 Targeting to bile acid and lipid metabolism in NASH treatment 1593 3383 4313 7077 1277 572 581 9965 PMC5723588__F2 Haem synthetic pathway 7389 210 1371 7390 2235 PMC5723694__F7 TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion 3458 6772 6774 PMC5726441__F6 PI3K pathway in human disease 5728 3667 5163 3717 6714 6446 4609 572 5292 PMC5729470__F1 Differences in pathway activation between left-sided vs right-sided CRC 2064 2065 5728 50808 6714 7297 324 6774 8313 6925 PMC5729535__F1 Extrinsic and intrinsic apoptotic pathways 8772 637 581 317 331 PMC5731741__F4 FGMD: A novel approach for functional gene module detection in cancer 51411 1890 654816 752 654817 6614 25900 168537 81704 10859 57705 55803 26253 51284 7096 3603 4064 64231 653361 64333 7099 79930 23533 10261 117289 139716 170575 3055 92241 58484 51311 3695 951 5294 11006 55340 64005 1234 8514 80896 22797 1240 146722 1439 4332 284759 6503 285195 10320 3059 3604 9046 124460 155038 285513 54518 8784 639 284417 10184 53831 219972 3676 968 147138 9459 10875 4542 10288 219855 79690 26191 10326 113277 9034 4069 PMC5732032__F4 Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma 3949 23476 6662 2290 19 PMC5736021__F2 PI3K signaling pathway 5163 4193 572 6009 PMC5738696__F1 IGF1R signaling pathway and its relevant drug resistance mechanisms: Promoting proliferation, inhibiting apoptosis and inducing changes to ABC transporter proteins and the ECM 3486 3490 3479 3481 3480 3667 2885 331 4193 581 7490 6667 406935 100302203 PMC5739082__F1 Simplified schematic depicting the mTOR pathway and associated “mTORopathies.” The mTOR pathway involves 2 complexes, mTORC1 and mTORC2 7249 7248 6009 1977 PMC5742686__F3 The NLRP3 inflammasome in ORKD development 10628 114548 3553 7099 PMC5743859__F4 Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders 10392 7187 6774 3665 PMC5747363__F2 Molecular targets of and mechanisms of resistance to major antimalarial drugs 1725 1719 1723 4519 PMC5751344__F3 Involvement of galectins during carcinogenesis 8829 3265 2932 1499 324 387 PMC5753586__F2 Non-canonical NFKB pathway in immunity and inflammation 7124 7186 7187 91662 56957 29110 5971 PMC5753586__F3 Non-canonical NFKB pathway in immunity and inflammation 643 29851 958 613 2638 PMC5757244__F5 Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops 7249 7248 23237 PMC5758710__F1 G10’s modified pathway diagram for the alfalfa lignin system 790 729230 1312 1230 PMC5762868__F1 Schematic diagram of the metabolic cycle of THF and the C1 metabolic pathway 25902 4522 6472 160428 275 10797 PMC5763483__F3 Potential cascade of molecular events leading to reduced differentiation of regulatory T cells for prevention of autoimmunity 22918 50943 920 4088 PMC5763493__F3 Deubiquitylation and regulation of the immune response 613 8915 4067 6850 1540 7186 PMC5765207__F3 Developmentally regulated signaling pathways in glioma invasion 3082 4087 4088 4089 2932 1499 2475 PMC5766549__F6 Milk protein synthesis in bovine mammary gland 5617 1392 2638 3630 PMC5767248__F3 AMPAR trafficking during Alzheimer’s disease (AD): early and later phases 2932 2534 6611 PMC5770599__F2 Regulation of Wnt/Beta-catenin signaling and oncogenic NFKB pathway by ubiquitylating enzymes in CRC 84133 54894 4040 4041 324 1499 7189 3725 2932 331 7124 PMC5772977__F1 The transforming growth factorB1/Smad signaling pathway 4092 4087 4088 4091 4090 4086 4089 PMC5775519__F1 Pattern recognition receptors (PRRs) for human immunodeficiency virus type 1 (HIV-1) recognition and the following pathway for triggering type I interferon (IFN-I) expression 3428 115004 4615 3661 3665 PMC5775519__F2 Type I interferons (IFN-I)-initiated signaling pathway leading to interferon-stimulated gene (ISG) expression 10379 6773 6772 PMC5776968__F5 Signaling pathway responding to oligodeoxynucleotides of class C 57506 613 9447 695 834 3553 6850 29110 3661 3665 54106 115004 4615 7124 4067 PMC5777301__F1 Type I Interferon signaling pathway 3454 3455 7297 11274 3716 6772 9636 6773 10379 PMC5777650__F6 Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy 8544 5163 253260 2475 PMC5777696__F1 S1P/S1P5pathway in mitotic regulation 8877 124976 5347 PMC5779957__F8 The top one Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of miR-146a-5p, hsa05200: Pathways in cancer 4018 1398 7054 PMC5787446__F4 Drug resistance related to aberrant glycosylation in colorectal cancer 1956 999 960 1869 PMC5787570__F6 Inclusion membrane proteins and secreted effectors from C 375 27131 58533 PMC5789791__F1 Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis and Liver X Receptor Activation in the PANDER Transgenic Model 642658 4280 7038 PMC5791370__F4 Proteomic analysis of the genes in Xllp08 and wild-type E 11113 4118 5539 6389 6390 PMC5794471__F4 Calcium signaling pathway 90550 2040 858 759 613 1610 PMC5794818__F2 T cell activation induces autocrine and intracellular complement activation that regulates T cell metabolic function and inflammasome formation 718 1514 4179 2475 940 50943 114548 8178 PMC5795054__F1 Scheme of the biosynthetic pathway downstream to phenylalanine 5053 100682260 3081 2184 2271 PMC5795421__F2 Human micro RNA (miRNA) pathway 54487 29102 619537 PMC5795449__F4 IDO1-mediated Tryptophan Depletion 3458 3459 3460 3717 PMC5795459__F1 Canonical type I and III IFN signaling 3588 3454 3455 3716 7297 6773 6772 10379 PMC5796908__F1 Activated endothelial cells modulate allogenic T lymphocyte activity 3383 920 3458 7054 PMC5801050__F3 Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation 1499 8405 131377 PMC5802554__F1 Mutational heterogeneity of angioimmunoblastic T-cell lymphoma indicates distinct lymphomagenic pathways 54790 7409 1788 387 3418 940 PMC5803917__F6 Factors implicated in manifestation of disease during drug treatment 5580 5579 5091 5747 1398 9021 5925 5829 7959 PMC5805715__F4 The gene targets of miRNA identified by NGS in the AIS patients and their role in osteoblast and osteoclast differentiation depicted from KEGG and DIANA miRPath v3 4089 4090 4086 652 650 2247 860 4087 4088 121340 1499 324 2932 1513 4774 100187907 PMC5807065__F4 Insulin signaling and type 1 diabetes mellitus pathways 2308 8835 7124 3558 8651 208 9021 5566 6247 3667 PMC5807095__F3 Hedgehog signaling pathway components in the ovary 2661 8643 5727 6608 64399 3549 50846 2735 2736 2737 59 1586 6770 PMC5810418__F6 Small Wnt Pathway Solutions to ubiquitinated Beta-catenin, denoted by a post-translational modification with a ‘U’ 1499 8454 6500 324 8313 PMC5810418__F7 Small Wnt Pathway Solutions to nuclear Beta-catenin, denoted by a compartment marked ‘n’ for nucleus 89780 7855 1499 4040 324 8312 8498 PMC5813884__F6 Influence of the RTG pathway on nitrogen metabolism 54903 48 3417 3418 PMC5814345__F6 Ezrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma 3082 4827 6667 PMC5817857__F2 An RTK and the downstream PI3K/AKT pathway 2475 64798 253260 PMC5818278__F2 Synthetic scheme of CS oligosaccharides using enzymes 4860 1311 266710 PMC5818424__F7 Hypothetical model for the pathogenesis of glucose intolerance and insulin resistance in TRIM31−/− mice 7099 11074 114548 3553 PMC5819894__F2 Apoptosis pathways 835 572 7124 8772 841 4170 637 836 840 581 842 PMC5819894__F6 Metabolism pathways 2539 57103 2194 9997 PMC5821620__F1 Bidirectional E-cadherin/catenin–EGFR cross talk in epithelial biology 999 1499 6714 2475 PMC5828319__F4 CD200R-induced signaling pathway 3717 6714 9046 6772 PMC5829655__F1 Hypothetical model summarizing the probable mechanisms of severe inflammation in malaria 7187 4615 3553 2625 PMC5830027__F2 Metabolic pathway of NUCKS1 in physiological and pathological process 64710 406928 3569 407055 406892 PMC5833861__F2 Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies 324 940 941 942 PMC5835589__F1 Targeting DDR vulnerabilities of SCLC 5925 4609 1869 545 472 993 994 995 7465 1017 PMC5836295__F1 Regulation of IL-33/ST2 pathway by sST2, IL-33 neutralizing antibodies, and GSK3Beta-regulated ubiquitin-proteasome system 90865 54620 2932 PMC5843858__F4 Diagram showing the possible mechanism involved in the difference between the angiotensin-converting enzyme (ACE) I/D polymorphisms affecting the generation of kinin peptide agonists for B2R and B1R in the downstream variation signaling effects 1636 1368 3667 2475 PMC5845388__F5 Germinal center pathway in systemic lupus erythematosus 7054 5091 2638 PMC5845450__F1 Central metabolic pathways of Geobacillus LC300 based on the genome annotation 6866 11113 4118 PMC5850280__F1 Wnt activity is necessary for heart development and becomes very low in the adult heart 11197 1499 9242 PMC5850946__F5 PI3K-Akt signaling and Ras signaling pathways 7534 2261 3908 2885 2264 5584 999 3265 7249 5523 2263 595 5728 3791 PMC5850946__F7 Ras signaling cross-talk protein transport 6810 5371 5156 2524 6469 8822 2114 3791 10972 2885 2263 7249 2264 10652 6184 79090 6845 22796 6955 PMC5854325__F1 Death receptor-mediated apoptosis signaling 7124 355 331 8717 8772 PMC5858971__F2 Targeting the IL-6/JAK/STAT3 signalling axis in cancer 8651 9021 5789 56940 6774 5770 5771 10401 6714 64236 PMC5860983__F11 Human binge alcohol intake inhibits TLR4-MyD88 and TLR4-TRIF responses but not TLR3-TRIF pathway: HspA1A and PP1 play selective regulatory roles 7099 7098 4615 3661 7124 PMC5863775__F1 MST2-RASSF protein–protein interactions through SARAH domains 355 3845 369 4485 9113 26524 4193 PMC5864864__F7 Proposed model of the temporal contributions of Wnt ligands and Beta-catenin to Alpha-galactosylceramide (Alpha-GalCer)-induced interferon gamma (IFNG) and IL-4 responses by liver natural killer T (NKT) cells 324 6422 22943 1499 PMC5867300__F1 Immune modulatory signaling in antigen-presenting cells (APCs) induced by binding of interleukin-10 (IL-10) to the IL-10 receptor 7297 3716 6774 3596 9021 2548 3587 3553 PMC5870354__F2 SignalingEpithelial growth factor receptor signal transduction 1950 1956 2885 5335 3716 3717 5163 6772 6774 2475 PMC5880504__F8 Proposed pathway regulating cultured primary mouse hepatocyte levels of ECs: impact of phytocannabinoids (Δ9-THC), 2-AG, and Fabp1 gene ablation 213 2166 2168 PMC5883109__F9 EH regulates PGN-induced inflammatory response in DCs 7097 114609 51135 3656 7189 2932 4615 PMC5885413__F3 LncRNAs regulate Rho/ROCK signaling in cancer metastasis 998 387 5880 7074 84740 55384 5879 732253 171022 389 4313 PMC5888911__F7 Schematic representation of the influence of high NT on FA anabolism and catabolism biosynthetic pathways 4018 4099 5091 PMC5889847__F3 CircRNAs function as ceRNAs in the regulation of apoptosis in tumor cells 8772 581 637 317 PMC5891588__F1 Development of NEPC by the SRRM4-mediated RNA splicing network 3169 51317 84530 PMC5892715__F1 Breaking up with ATM 472 9656 9025 3014 PMC5893443__F8 Dual Catenin Loss in Murine Liver Causes Tight Junctional Deregulation and Progressive Intrahepatic Cholestasis 999 1499 727 4040 4041 PMC5895694__F1 Cross talk between CEA, TGFB signaling, and IL6-STAT3 pathway 6774 4088 4089 7048 7046 PMC5904768__F5 p53 signaling in the TRIM59 network 28996 545 472 11200 2033 11073 1017 894 1019 1869 PMC5908737__F3 MUC1-C ACTIVATES POLYCOMB REPRESSIVE COMPLEXES AND DOWNREGULATES TUMOR SUPPRESSOR GENES IN HUMAN CANCER CELLS 4609 648 6015 7038 PMC5911724__F5 PI3K–AKT signaling pathway 2885 5594 5604 672 2997 5105 7097 3667 28227 5879 4609 117145 6850 3492 5170 118788 930 595 1027 1440 1441 10000 2309 5934 3320 11140 356 2335 5728 598 200186 572 596 23035 842 4515 10488 4170 10161 10681 6256 3164 1147 4790 4602 7157 4193 5894 10971 PMC5912161__F1 Drug-Free Macromolecular Therapeutics Induce Apoptosis via Calcium Influx and Mitochondrial Signaling Pathway 100187761 4118 4810 PMC5915062__F4 Proteomic alterations in early stage cervical cancer 7284 2318 5954 1294 2274 1021 1019 3925 813 2316 1824 3383 3858 2633 5317 1832 3866 1830 3728 2125 5792 7153 9114 3713 1829 481 3860 1382 5493 6513 PMC5915062__F5 Proteomic alterations in early stage cervical cancer 2237 10592 5111 5591 4176 7936 4172 4175 8467 10579 4171 4173 2332 9584 4174 6241 4522 11214 9373 2923 4643 6890 55178 811 5982 5983 PMC5916807__F7 Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types 5728 324 7157 7015 4609 6502 9978 9656 8454 9025 165918 56852 672 8945 10297 8924 991 999 996 325 PMC5923293__F6 Ingenuity pathway analysis (IPA) of miR-152-3p-target interactions in prostate cancer signalling 5925 367 51176 PMC5923349__F1 Hippo signaling pathway in Drosophila and mammals 60485 4485 9113 26524 PMC5927694__F1 A conserved parallel pathway for telomere protection 84126 545 472 PMC5927979__F2 Interaction network of microRNAs identified potential mRNA targets involved in clinical features of antiphospholipid syndrome 7422 558 659 8526 3643 1871 1910 3096 5467 7750 6340 11214 81846 147463 401474 2186 51285 5797 783 6347 961 9732 23530 55742 4147 4205 3920 PMC5929433__F1 Ceramide species are elevated in human breast cancer and are associated with less aggressiveness 94101 29095 94103 57704 64781 7357 427 6609 56624 6610 55512 259230 55627 727 166929 392275 8879 PMC5930795__F5 Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity 26291 875 2691 7200 3479 468 3667 6779 PMC5931110__F1 Immune activating and suppressive effects of DNA double-strand break (DSB) signalling 9156 472 545 3659 PMC5932555__F2 Design and application of scaffold RNAs controlling both genomic target sequence and regulatory function 4601 100271694 1356 PMC5933117__F6 Model of rRNA biogenesis in rice 11201 5464 717 PMC5935095__F3 Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape 3717 4507 10419 1786 2475 PMC5940413__F5 Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer 5290 4214 3667 2885 2475 PMC5941822__F1 Insulin signaling pathway 435 5728 7248 7249 6009 2932 4609 PMC5943524__F8 Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 56848 8877 340485 PMC5945668__F3 Contraction of smooth muscle cell: cellular pathway and the role of MYL9 and of other genes related to MMIHS 10398 6010 367 PMC5961736__F4 PD-1/PD-Ls signaling pathway that acts as effective therapeutic targets in lymphoma 324 7535 2475 PMC5962337__F1 Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress 9997 1353 540 538 10063 90639 475 6649 9973 1356 6341 130749 PMC5962337__F7 Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress 366 364 57412 2597 4520 PMC5963715__F3 PI3K/AKT/mTOR signaling pathway 5728 7249 6009 2475 PMC5969374__F5 Disrupted signaling pathways in ABC-DLBCL 973 613 695 958 6850 84433 8915 4615 10892 3662 2475 604 PMC5971010__F1 Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans 441478 102 29127 PMC5972417__F7 The FA pathway and SPR-5 cooperate in DNA repair and regulation of histone demethylation 57697 22909 2177 PMC5978700__F2 Role of RAS enzymes in the EGFR signaling pathway 1950 7039 1956 PMC5979342__F5 miR-302s target genes are involved in the loss of epithelial phenotype 324 51176 8754 5099 8538 5310 390 960 5396 3909 1004 2254 7048 694 207 6049 7145 4009 10009 8323 3625 7976 8850 1812 1641 3691 10220 PMC5979469__F3 Positive regulation of TERT by WNT signaling pathway specific protein (Beta-catenin) and STAT3; (B) SMAD transcriptionally repressed TERT; (C) BC032469, a lncRNA contained sequences which showed complementarity to miRNA-1207-5p seed regions 7015 1499 4088 6774 PMC5980154__F6 Schematic diagram illustrating how ɑ‐LA, via regulation of Grb2 expression, modulates different signalling pathways that participate in proliferation‐related stress responses 1950 3082 2549 2885 6714 2475 7018 PMC5983164__F2 RAS effector pathways 5728 5163 3667 7249 7248 572 PMC5983678__F1 GPCRs signaling pathway in HCC 4018 6010 759 619501 PMC5986469__F7 Illustration of the Compound-Group-Target-Pathway (CGTP) network 3320 1017 4846 6714 367 3558 2147 213 4129 7421 5478 2224 7276 4311 5950 1991 4306 PMC5988853__F2 Interplays of interleukin-23 (IL-23), IL-6, signal transducer and activator of transcription 3 (STAT3), and retinoid-related orphan receptor Gt (RORGt) in the differentiation of pathogenic T helper 17 (Th17) cells 7297 3717 1235 6364 6774 PMC5989100__F2 Major signalling pathways involved in the control of skeletal muscle hypertrophy and mitochondrial biogenesis 3479 7249 7248 6009 2475 PMC5991449__F3 Overview of the pathways involved in odd and even fatty acid production including the link with the TCA and methyl citrate cycles in Yarrowia lipolytica 355 48 50 PMC5992182__F6 RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors 673 1540 828 PMC5992490__F2 Actions of IGF-1 and angiotensin II in skeletal muscle 3479 3480 572 PMC5992580__F1 Gene clusters identified via gene interaction analysisLines indicate a physical interaction, as assigned by the GeneMANIA plugin for Cytoscape 4436 22985 5591 675 545 841 4683 8795 2890 9400 79728 22897 5606 4137 23178 3987 1639 2243 PMC5992788__F1 CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease 351 5066 283459 PMC5995146__F2 Parkinson’s disease: From human genetics to clinical trials 120892 55737 6622 25793 2580 65018 PMC6000073__F1 LKB1及其下游相关靶点信号通路示意结构图Schematic illustration of LKB1 signaling pathway and related downstream targets for cancer therapy 2475 4513 4015 PMC6002979__F2 Canonical and non-canonical NFKB signaling pathways 4049 7099 7189 2475 5971 PMC6009840__F2 Metabolic Reprogramming in Kidney Cancer 4128 4129 1644 217 PMC6011013__F4 mRNA expression data: BMD+DAD-screening network using Coxnet (left) and ADMMnet (right) methods with mRNA expression data and the integration of mRNA data and CNAs profiles 2064 8317 6241 9088 2328 127623 103910 6869 222 26188 108 2740 596 2264 10798 PMC6011883__F2 Complexes formed by mutant p53 and their roles in breast cancer 7124 3643 207 153090 5879 29843 PMC6020372__F2 Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC 10765 378938 857 2810 387 PMC6025294__F2a JMY in p53 Regulation 1869 133746 11171 472 4193 PMC6025837__F6 Thyroid hormone signaling pathway 6256 6955 1499 4193 6257 7249 6009 2475 6957 5208 572 5728 842 PMC6027262__F4 Pathway overview of Salmonella carbon metabolism under Pi starvation 6120 22934 3939 PMC6028704__F1 Sub-network with a size cut-off of 28 between D-glucose and L-phenylalanine in S 2695 144717 5091 5183 11113 5185 PMC6030864__F1 Pathway relationship network 4117 2475 4118 PMC6034319__F3 Cross-talk between tumor, MDSCs and immune cells for development of HPV-related carcinogenesis 6347 7852 2621 1950 6387 6352 8205 PMC6036444__F1 Schematic of one-carbon metabolism 275 6470 6472 4522 10797 10840 25902 160428 1719 PMC6038278__F2 MiRNA-mRNA associations involving genes in the KEGG TGFBeta-Signaling Pathway by location of action: extracellular factors (a), membrane receptors (b), and nuclear factors (c) 7057 1875 60436 7027 4609 5933 PMC6038340__F8 Intra-pathway feedbacks and BRAF/MEK growth-inhibitory synergism 3845 673 1956 PMC6040091__F4 WNT/Beta-catenin signal transduction pathway 4040 4041 1499 324 PMC6049001__F4 In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway 57506 3661 3665 PMC6051204__F1 Folate‐mediated one‐carbon metabolism, links to methylation reactions and nucleotide synthesis (by Cheng TY et al 4522 8836 4524 6573 6470 6948 10797 635 4552 1719 4548 2618 6472 875 27430 PMC6052888__F9 Antioxidants neutralize mitochondrial ROS (mtROS) 27349 23410 7351 PMC6053540__F4 Biogenesis of miR-451 29102 2638 27161 PMC6054220__F2 Autophagy induced by nutrient and nutrition stresses via the mTOR and AMPK signal pathways 64223 64798 6009 2475 7249 PMC6054915__F6 Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells 7008 4155 4340 324 PMC6054955__F4 Immune Responses of Epinephelus coioides to sigX 940 920 29851 3586 613 958 10803 7852 727 729 730 PMC6056829__F1 GPI biosynthesis in yeast 2821 2875 100187761 PMC6057898__F3 Interplay between melatonin and clock genes in joint during OA 5187 4783 8864 3553 9575 406 23411 176 6662 1280 PMC6058973__F2 Regulation of GPCR signaling 3458 6772 7494 PMC6063270__F1 Repeated Cis-Regulatory Tuning of a Metabolic Bottleneck Gene during Evolution 5236 55276 51083 PMC6064949__F10 A model depicting the mode that hypoxia exacerbats acute lung injury (ALI) via the toll-like receptor 4 (TLR4) signaling pathway and the protective effect of hypoxia-inducible factor 1 alpha (HIF-1A) 3929 929 7099 3569 3606 3553 PMC6065096__F8 R431C mutation induces hyperproliferation, hypermotility and ER stress-induced apoptosis in podocytes 54443 2475 23607 5879 PMC6067120__F4 Schematic representation of estrogen metabolism and AHR signaling pathways 196 405 1312 1544 1543 PMC6067831__F1 The HPA axis 1325 1392 1394 PMC6073700__F2 The SOCS proteins mechanisms of GHR-JAK2-STAT pathway inhibition 3717 9021 8651 6774 8835 PMC6082390__F2 PC1/3 activity is essential to the leptin–melanocortin pathway 23237 4852 181 5443 4160 PMC6084451__F1 Host-Intrinsic Interferon Status in Infection and Immunity 57506 3661 2973 10379 6772 6773 PMC6085137__F1 FOXO1 regulates activation and function of dendritic cells 2308 1236 3383 941 942 253260 2475 PMC6085483__F1 Metabolism is a key feature of every quiescent cell 355 7038 2475 4118 PMC6086630__F7 Network mappings were Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of HOXA3 co-expression genes in NSCLC 1030 3624 7042 7043 4824 1634 25865 4286 2122 1956 182 10000 2318 64411 10891 9759 80310 5054 4638 2737 PMC6089339__F7 Summary of the location pattern of CFP (blue), YFP (yellow), neuronal (PV) and activity markers (Arc) in the hippocampus 5199 759 627 2271 5091 761 2638 100187761 23237 PMC6089851__F3 Activation and feedback regulation of the MAPK pathway 2885 2534 6714 1848 1847 4170 596 595 7039 1839 1843 PMC6089887__F3 Metabolic pathway map in the plasma comparing common bottlenose dolphins (n = 3, blue columns) and beagle dogs (n = 3, red columns) 23440 183 65057 1611 100653366 8190 1636 PMC6093060__F7 NFKB inflammatory signaling pathway 7099 4615 3603 PMC6094676__F1 Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma 3815 4893 5728 4763 673 2932 2475 4194 4193 6195 572 1019 596 PMC6096230__F1 NOTCH signaling and graft-versus-host disease 3714 182 4851 920 3280 PMC6097550__F1 NRAS mutant melanoma: an overview for the clinician for melanoma management 4893 1021 1019 PMC6102093__F1 Schematic illustration showing mechanisms of smooth muscle cell (SMC) phenotypic switching 9927 1727 27035 50507 59 4629 PMC6103457__F1 Cilia and intraflagellar transport 8100 26160 28981 57560 9742 55081 80173 55764 79989 90410 51098 112752 56912 11020 51668 64792 1283 PMC6104630__F2 (B–catenin mediated) Wnt signaling pathway 2932 324 389058 PMC6107301__F8 The conversion of a T:G mispair to a T:A mutation by guanine oxidation followed by long-patch base excision repair 5423 4350 324 PMC6113920__F1 The human adrenal cortex: growth control and disorders 552 2696 4158 79798 PMC6115979__F3 TRPM7 kinase in T cell signalling and transcriptional regulation 7046 54822 4087 4089 3570 6774 7018 6097 3682 PMC6117946__F3 Non-enzymatic Krebs cycle-like reactions that occur in the presence of peroxydisulfate and FeS form a network that closely mimics the typical (oxidative) Krebs cycle and the glyoxylate shunt 11113 4118 2242 PMC6121505__F2 Inhibition of apoptosis mediated by mFas and TRAIL 8772 5266 1950 331 PMC6121505__F3 Role of TLR3, 7 and 9 in SS 7098 54106 51284 4615 7189 29110 8772 3661 3665 1950 PMC6126141__F1 Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic implications in a peripheral neuropathy 6663 55818 3066 23081 1959 101180900 23135 6469 2668 5948 4199 79831 PMC6126377__F2 Schematic diagram illustrates how tilorone and hypoxia may share common mechanisms in the mediation of the preconditioning response 11277 115004 3437 3434 9636 6772 3661 29110 PMC6128202__F1 Main signaling pathways affected in high-grade gliomas 1956 4763 2475 1019 PMC6133069__F8 Schematic depiction of the results and proposed hypothesis 156 3717 2534 23530 PMC6134813__F4 Pathways Involved in Ovarian Epithelial Cancer 259266 187 5733 1268 57405 55143 4283 5173 220134 1062 283869 3627 9156 83540 6373 2917 2305 2840 23397 10563 2792 55388 PMC6138823__F3 Hepatitis C virus-apolipoprotein interactions: molecular mechanisms and clinical impact 335 19 3931 9619 1071 5360 3949 PMC6138873__F1 A model depicting cryptochrome signal transduction mechanisms in Arabidopsis 64326 1407 1408 PMC6139646__F6 Metabolic pathways impacted by PEPCK in the small intestine of mice 11113 4118 4099 PMC6140770__F9 Regulation of AMPK signaling in DM1 muscle 23411 6780 4154 1760 PMC6142327__F3 Role of AMPK signalling pathway during compensatory growth in pigs 3875 59277 860 1113 5321 923 PMC6144698__F1 STAT3 activation pathway 3976 1270 5008 1950 3082 7039 6420 9021 6774 PMC6144938__F3 Important steps in cholesterol synthesis and homeostasis 3949 9619 22937 19 1717 1718 1583 PMC6152528__F11 Hypothetical model for the signaling pathway and the role of FKB-induced autophagy in GBM cells 468 1649 57761 2475 6198 9474 10533 PMC6154041__F3 The role of Wnt5a-Ror2 signaling in osteoclast differentiation 7474 4920 6010 29941 3725 6667 PMC6156841__F1 Human Disease Phenome construction 55851 351 23385 5664 5663 374291 4704 4728 6389 4137 9627 120892 4729 6622 65018 27429 11315 PMC6160134__F2 TGFB signaling and apoptosis 9518 7422 6655 7189 29110 8915 4091 8027 4215 841 1844 4092 4214 4609 637 598 836 596 10370 860 3665 4616 10018 PMC6160231__F3 Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase 6776 2268 2534 1499 6714 4067 3055 3932 65125 PMC6160397__F5 Proposed model for PD-L1 induction in CC 55553 5728 65268 1499 PMC6160488__F4 Crosstalk between the interferon signaling pathway and PD-L1 signalosome 3454 3716 3717 840 836 6772 842 6773 6774 207 4763 472 55697 9675 545 5297 23047 PMC6160678__F6 An comprehesive metabolomics and transcriptomics study to identify metabolic pathway alterations in CFG treatment of ovarian tumor-bearing mice in vivo 3906 7360 6319 33 35 2683 PMC6160868__F1 Wnt/Beta-catenin driven mevalonate metabolism promotes EMT 1499 6935 47 3157 3156 4598 10654 4597 3652 2224 PMC6166676__F1 Study design 5781 4397 5771 PMC6167442__F2 Detailed diagram for fatty acid and phospholipid synthesis in C 716 5662 5182 5183 PMC6167501__F2 PI3K-Akt pathway activity 5170 5728 4193 2308 572 2475 PMC6173473__F3 Crosstalk of bone cells within bone marrow regulates bone remodeling, adipogenesis, hematopoiesis, and angiogenesis 9242 3952 5468 3953 2920 3091 154 55366 2056 6423 PMC6174285__F1 Cyclic nucleotides signaling pathway in plant cells 2638 11168 52 PMC6176484__F4 Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer 4040 6608 2932 1499 6469 PMC6177397__F2 RDGN regulates TGFB signaling transduction in tumor cells.Notes: TGFB binds to TBR and activates SARA, which then recruits and activates intracellular SMAD2/3 protein 4087 4088 4089 6495 1602 PMC6177401__F5 Dengue virus and the host innate immune response 7297 3716 721 718 6773 6772 716 23352 PMC6186122__F3 Schematic of the extrinsic and intrinsic coagulation cascade 7018 7035 100306940 2160 5091 324 2147 PMC6186458__F1 BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis 8772 637 581 331 PMC6192420__F2 Overview of the vitamin D metabolic pathway 1593 6591 5292 1573 7421 1628 PMC6194902__F1 Terpenoids biosynthesis pathway (A), and pathway engineering strategies (B,C) 727 729 3652 717 718 7018 PMC6195654__F11 BMP signaling pathway overlapped with the results of the comparison BAVc vs 651 652 654 653 655 353500 9241 8646 10468 25928 26585 331 4090 4086 4091 10454 4089 814 860 3725 3196 4092 1482 5308 PMC6198212__F1 Interactions and functions of NRPs 3082 7048 7046 6714 PMC6199358__F2 The Wnt/Beta-catenin and other signaling pathways 1499 2932 324 51176 4088 PMC6200076__F1 Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma 673 2475 6446 PMC6200703__F2 Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis 100124700 5820 6774 10533 64422 9140 2475 84971 55014 5725 3146 3925 378938 PMC6202553__F4 Gene networks 4313 596 2260 2065 51083 3488 5156 3481 6387 5327 367 1462 5727 8000 4915 5176 3815 PMC6204284__F2 An illustration of spontaneous DNA double strand break induction and their roles in maintaining the stemness and tumorigenicity of cancer cells 472 790 2021 836 6774 PMC6209660__F6 Potential mechanism of sodium butyrate on STZ-induced type 1 diabetes 3146 920 3553 PMC6213406__F1 Putative anticancer effects of MTF exemplified by molecular and cellular key events 253430 6720 2475 6774 595 PMC6213474__F2 Sonic Hedgehog (SHH) molecule or SHH secreted on extracellular vesicles (EVs) mediated functional improvement of endothelial progenitor cells (EPCs) 6469 693187 693193 51684 387 PMC6215910__F7 Model illustrating the potential pathway from pseudohypoxia-induced cilia loss to increased cell proliferation and dysregulation of tumorigenesis relevant cilia-mediated signaling pathways in PCCs 10013 2271 7428 PMC6220136__F1 EGFR signaling and generation of Treg and tol-DC 374 1950 1956 3717 6774 50943 PMC6220384__F2 HMGB1 and Fas/FasL signal pathway in uveitis 3146 355 3383 7412 PMC6221654__F5 Gene regulation network of 4 gene signature models 6775 4782 4763 288 55656 4602 1051 5915 7157 6772 9381 50943 4773 6908 2113 22998 54676 3725 6925 30061 367 2908 10970 4150 2118 2002 3689 2114 3684 3683 3235 6928 5079 1910 7076 2624 7058 7412 3383 4205 4772 7528 1050 1277 6256 2335 1301 PMC6224961__F2 Regulation of priming and fusion of insulin granules by glucose and the incretin GLP-1 1080 6616 55107 PMC6232459__F7 HBSP regulation on PI3K/Akt signaling to affect Fas-apoptotic pathway 355 5170 8772 PMC6235777__F1 Graphical representation of IFNG signaling pathway 6714 5914 100187761 91653 2353 374 9373 1611 367 PMC6237163__F7 The effect of fold change with RNA-seq analysis for toll-like receptor nine signaling pathway in lung 4615 51135 3654 23118 4790 54106 PMC6237873__F5 LncRNA-mRNA interaction networks 3725 655 6010 PMC6243101__F1 Autophagy as an anti-inflammatory process 2475 3553 3606 PMC6245608__F3 Physiological regulation of autophagy in the heart 3667 6009 2308 2309 2152 8408 7942 PMC6245940__F4 Dysfunctional HDL and atherosclerotic cardiovascular disease 949 9619 19 7038 1071 3931 PMC6250427__F4 Mitogen activated protein kinase (MAPK) signaling pathway 4609 7018 4149 PMC6251731__F6 Involvement of Akt in Mitomycin C and Its Analog Triggered Cytotoxicity in MCF-7 and K562 cancer cells 2885 3611 5728 3550 84969 4193 388 4535 9518 79923 2475 1977 4170 11140 6009 PMC6252326__F1 Schematic representation of the tryptophan metabolism pathway 8942 8564 23475 PMC6254660__F7 Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation 5728 4609 2475 283871 3091 PMC6257835__F7 Involvement of circRNAs in the Hippo signaling pathway 5519 5518 5515 5501 84552 84612 5520 5521 5522 5584 4771 56288 92597 55233 26524 3398 23513 4087 4088 4089 4092 6591 6657 6932 6934 7003 7005 7040 7042 7046 7048 7159 7161 7480 7481 51384 3397 2736 392255 8324 8323 7855 8322 7976 8321 122786 79981 2246 23291 1857 1742 1741 1740 1739 1499 29119 1496 1495 23286 25937 2932 7529 7531 7532 8945 659 658 657 655 60 650 652 7533 10971 7534 374 23418 166824 653 51176 60485 27113 10413 5500 8313 9113 894 656 332 PMC6261473__F1 Nrf2–Keap1 signaling pathway 9817 5052 4094 PMC6262346__F1 Metabolic pathways involved in glucose, fructose, and xylose catabolism in B 9942 22934 6120 7086 PMC6269119__F1 The activation of an intracellular channel promotes the trafficking and secretion of a cytokine 7099 6347 107966124 PMC6271242__F1 The PI3K signaling pathway and sides of action PI3K/Akt/mTOR pathway inhibitors 613 5728 84433 8915 10892 64223 253260 PMC6271622__F1 Regulation of antioxidant and detoxifying genes by the NRF2-Keap1 pathway 8452 2810 9817 PMC6273696__F27 G2/M DNA damage check point signaling pathway was regulated by vancomycin in HK-2 cells 4194 28996 472 545 4193 9320 1111 8493 6790 79866 4661 56475 7465 PMC6273696__F36 ER stress signaling pathway was regulated by vancomycin in HK-2 cells 840 100506742 842 7186 7494 22926 468 811 PMC6274245__F6 Regulation of posttranscriptional modifications of NFKB and histone H3 with and without TNFA stimulation 79918 23411 3065 3066 PMC6274779__F5 DEGs involved in glycerolipid metabolism and fatty acid degradation pathway 1376 51 95 8526 160851 5066 PMC6274918__F2 Maternal Beta-Cell Adaptations in Pregnancy and Placental Signalling: Implications for Gestational Diabetes 5617 3082 1950 3172 1956 27022 2475 2305 894 PMC6277637__F3 Main brain-immune system pathways and feedback loops illustrating the interconnected effects of physical and emotional stress in health 1401 551 7200 717 PMC6279936__F1 Processes of liver fibrosis progression and regression during human hepatosplenic schistosomiasis 7054 3146 3565 1950 PMC6280608__F6 The search page of prescription category as seen by submitting different names 5972 100187761 367 PMC6280608__F2 The shared targets and pathways in Yu Ping Feng 56961 27040 351 PMC6281418__F7 Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood 8313 4609 7476 1956 89780 7472 3725 54115 7471 PMC6281690__F4 Schematic illustration representing metabolic and transport proteins hypothesized from the genome of Ca 175 100187761 9118 1636 2271 367 5995 PMC6284793__F8 Known and novel BP associations in the TGFB signalling pathway 3624 7042 7040 658 92 6497 22808 57154 2885 6237 5605 8928 860 3065 864 1482 5308 3196 145258 3665 4838 PMC6286780__F1 Zinc and zinc transporters are involved in FcERΙ-mediated mast cell activation 2534 9846 387 PMC6286812__F2 NOD-like receptor signaling pathway from KEGG shown with drugs, targets and known mechanism of action (→ denotes activation, ---> and ---> denote indirect effect and — denotes binding/association) 84674 841 10392 7205 7189 6347 10454 64170 64127 23118 257397 55914 834 838 9051 3553 PMC6287006__F5 KEGG analysis of hsa-miR-210 target genes 3625 4091 5163 91 161 9815 1871 11031 5594 30845 2260 8844 375 117283 23533 9267 8831 1609 1435 1944 3632 160851 3798 PMC6287681__F4 Autophagy signaling pathways induced by NPs 8408 5266 8678 9140 7038 9474 10533 83734 30849 22863 55054 64422 PMC6288187__F1 Vasorin 3D structure: Cartoon representation of the structure model of Vasn predicted by RaptorX (http://raptorx.uchicago.edu/) 114990 102 6868 4089 4087 4088 8650 PMC6299090__F7 miR-100 maintains phenotype of tumor-associated macrophages by targeting mTOR to promote tumor metastasis via Stat5a/IL-1ra pathway in mouse breast cancer 2475 2736 2737 6776 PMC6302376__F5 Regulatory relationships between genes in a signal pathway regulating the TP53 gene 472 7157 4193 PMC6302460__F3 Comparison of four TPs in breast cancer subtypes 2885 7248 7249 572 6256 PMC6302517__F3 Schematic illustrating the role of cav-1 in different cell 857 7099 4615 PMC6305104__F2 MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer 5771 1154 596 8835 5292 10254 4170 6775 598 6772 3716 5777 595 10379 1387 316 2273 2670 4609 10000 2475 693225 6654 3265 5894 2885 8503 5295 5296 406952 406971 PMC6305196__F9 Model for the CK-dependent photomorphogenic response in etiolated Arabidopsis seedlings 108348016 64326 55070 PMC6305318__F2 Summary of the interactions between SIRT1 and the canonical Wnt pathway 23411 2932 324 3146 1499 860 PMC6307429__F3 Role of the NFKB pathway in the miR-155/SOCS1 axis in the immune system 7099 7189 4615 54472 23118 8651 PMC6309606__F6 RAS/ERK, PI3K/AKT, WNT and Beta-catenin signaling pathways are involved in different stages of brain development and are commonly disrupted in ASD 1499 5728 7248 2932 PMC6311498__F1 Cartoon illustrating the intracellular distribution of ATP7A, ATP7B, and DBH 538 540 1621 PMC6316148__F2 Relationship between mechanical loading and sclerostin expression 4040 4041 50964 PMC6316356__F2 Graphic representation of the hepatic Hepc pathway in conditions of systemic iron increase 164656 3077 7036 PMC6318069__F1 Three tooth agenesis-associated signaling pathways 10913 1896 64388 4054 128178 23118 7189 8313 1499 324 4487 5083 PMC6320922__F1 Drosophila Jak/STAT signaling components and the corresponding human homologs and their protein families 6772 6773 6777 6776 6775 6774 6778 10549 5052 10642 3569 9655 8651 1052 1050 8554 604 2139 2138 2186 254065 55023 5978 55833 6714 1445 PMC6321037__F2 S100A10 plays a key role in regulating pro-tumorigenic processes including proliferation, adhesion, motility, invasion, metastasis, and therapy resistance 6281 302 5340 PMC6321180__F2 Wnt1/Beta-catenin signaling regulation of midbrain dopaminergic (mDAergic) neuron survival/death according to our published findings [,,,,,,,,] 324 2932 51176 55366 8549 4041 4040 PMC6321180__F3 Wnt1/Beta-catenin signaling as a key player in glia–neuron cross-talk 7471 3603 7474 2932 PMC6323527__F1 Core metabolic pathways for T cell survival, activation, differentiation, and function 1374 717 6714 PMC6325472__F1 PI3K pathway activation and cell-cycle in tumor cells 5728 2932 1021 1019 717 1443 5266 PMC6326357__F1 Role of MAIT cells in spondyloarthritis (SpA) 325 324 969 3140 6097 729230 1235 149233 3575 10663 PMC6329659__F4 Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair 27185 472 2932 3014 PMC6333596__F2 Sonic hedgehog signaling pathway 6469 6608 5727 51684 2735 6657 595 PMC6334777__F4 Activating MAPK Pathway Mutations in LCH 2065 369 5604 598 1236 PMC6335100__F2 Mechanistic target of rapamycin (mTOR) signaling network 3667 2885 5728 4763 5163 153129 652968 6009 468 9776 8408 7942 PMC6337659__F2 Proposed mechanisms of polycystins implication in CRC 6714 2475 1499 PMC6338618__F7 Proposed model for the role of inhibition of BCLM by Ponatinib 3725 51129 4312 5743 3371 PMC6348604__F1 Apoptotic signaling pathway 572 581 596 PMC6349126__F1 Schematic outline of PC metabolism in yeast 51573 5091 151056 2817 PMC6349928__F1 Non-coding RNAs as integrators of the effects of age, genes, and environment on ovarian aging 2309 5728 268 406935 406937 PMC6350761__F1 Efforts in redesigning the antileukemic drug 6-thiopurine: decreasing toxic side effects while maintaining efficacy †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00463c 7172 8833 7077 PMC6354076__F1 Sirtuins and metabolism 23411 23410 51548 51547 23408 22933 23409 PMC6354331__F5 Enrichment analysis with DAVID 6.8 of the associated genes for the 4 novel diseases and COPD 260431 5447 6955 PMC6356271__F2 Terminal telomeric complex 54433 55505 55651 1200 79991 100134934 25913 472 545 6957 2641 7015 80169 PMC6358228__F1 Canonical pathway network analysis 1363 5126 7200 1444 2691 5122 5617 7040 7422 PMC6358786__F4 Alterations of the PI3K/Akt-Cyclin D1 pathway in cell cycle progression from G1 to S phase in 2-cell embryos 472 5728 1027 5163 51286 595 898 54549 2932 1021 1019 PMC6359191__F1 Cartoon representing the osteolytic and osteosclerotic vicious cycles 3479 7471 1950 3569 89780 3589 50964 PMC6361427__F8 Fine mapping of the major QTL for seed coat color in Brassica rapa var. Yellow Sarson by use of NIL populations and transcriptome sequencing for identification of the candidate genes 1312 790 5132 PMC6362409__F1 Microbiota and the intestinal barrier against infectious threats 920 7054 3569 3458 7099 7100 PMC6363620__F3 Complex interplay between CCT and actin and tubulin 284254 907 6722 PMC6365644__F4 Differentially regulated metabolic fluxes and metabolites in gluconeogenesis (A), pentose phosphate pathway (B), TCA cycle (C), arginine biosynthesis pathways (D), and respiratory chain (E) under 2-mg/liter colistin treatment for 1 h 11113 4118 1356 PMC6366304__F1 Common PI3K pathway aberrations found in a variety of solid tumor types 2263 5295 5290 5728 207 8821 5782 PMC6368395__F4 Oncogenic viral infections in post-transplantation malignancies 355 8772 1956 PMC6371621__F1 The mechanisms of microRNA biogenesis and its regulation of gene expression 54487 100187761 29102 5901 26523 192670 27161 192669 PMC6375051__F2 Mitophagy links oxidative stress conditions and neurodegenerative diseases 65018 10131 7416 PMC6376179__F4 Mutations in key pathways controlling cell growth 2625 3718 6778 861 2034 6774 862 1956 6926 2260 5728 2261 10000 3551 2065 7248 3480 1027 7249 5894 4214 673 3845 5605 5879 4763 1029 5925 894 595 7157 472 PMC6378284__F2 Mammalian Hippo pathway signaling 4485 4771 9113 26524 9686 2246 PMC6378304__F5 Strategies to overcome NK resistance in solid tumors 100507436 4277 6352 3627 3576 2919 1956 3579 2833 201633 PMC6381083__F9 Canonical and non-canonical NFKB pathway 958 4055 7186 4615 7187 5970 3663 5971 108348016 PMC6385418__F1 Homologous recombination (HR) repair deficiency represents an opportunity for a synthetic lethality approach through the use of PARP inhibitors (PARPi) 6741 142 940 PMC6387166__F1 Effects of distinct molecules produced by stressed cancer cells on NK cell-mediated functions 7097 115004 51284 51311 PMC6392423__F8 Protein kinase C pathway for prolactin regulation of metabolic gene expression in prostate epithelial cells as represented by mitochondrial aspartate aminotransferase 5617 7018 3725 2353 PMC6393786__F2 Optogenetic switches 4827 10763 5901 PMC6395542__F2 Dysregulated cholesterol homeostasis drives inflammasome activation 9619 9447 114548 19 4598 PMC6395781__F1 Mammalian O-mannosyl glycans: Biochemistry and glycopathology 10585 29954 84892 148789 55624 84197 2218 79147 11041 PMC6397698__F4 Mechanism of action for combined TGFB and PD-1 pathway inhibition 7048 7046 3459 3460 3458 PMC6398499__F1 Key components and potential pharmacological targets of Wnt signaling implicated in orofacial clefts 64840 7474 7484 8321 2535 340419 4920 6259 144165 1499 51176 7008 4487 79971 4040 2932 PMC6398499__F3 Crosstalk between Wnt, Shh, primary cilia and other related signaling components in orofacial clefts 1499 144165 2295 6469 11127 2737 8817 8100 PMC6398499__F4 Crosstalk between Wnt, RA and related signaling pathways in orofacial clefts 220 2255 6899 4040 56603 PMC6399846__F2 KIT mutant GISTs have enrichment for KEGG cell cycle pathway (p = 0.0007) and spliceosome pathway (p = 0.0008) using STRING v10 clustering of significantly somatic mutated genes (p < 0.003) 3084 7391 23072 2113 84074 285955 7157 6949 10913 3725 996 5925 26232 3815 8454 9685 8086 4437 2483 8175 11338 1195 27316 139804 PMC6402450__EV2 Metabolic Reprogramming in Colon Cancer 5226 57103 10606 5471 2194 5620 47 1743 3939 PMC6402819__F5 R-loops drive DNA damage responses 472 6741 545 84126 PMC6406290__F6 Network analysis of differentially expressed genes 4312 64061 3872 9693 PMC6406290__F10 Scheme of proposed IS-induced apoptosis via ROS-NRF2 and MAPK signaling pathways in human astrocytes 6098 1843 1850 1847 PMC6406345__F3 Protein–protein interaction network of associated genes in the etiopathogenesis of ANCA-associated vasculitis 100507436 629 10666 3123 3119 26191 54106 3122 3113 177 4855 3115 5657 1302 6257 7923 6015 3663 PMC6406640__F3 Schematic representation of gene silencing by siRNAs 29102 192670 27161 192669 PMC6407321__F4 Protection for oral SUB+IV vaccine against tick infestations in cattle 7054 3553 3603 718 PMC6412216__F5 Mediation of the maturation and activation of BMDCs during Mycobacterium bovis infection by the cGAS pathway 920 115004 29110 3661 3455 3454 PMC6412771__F2 De novo synthesis of NAD(P) from tryptophan, nicotinamide and nicotinic acid 8942 125061 8564 23475 55191 10135 PMC6420874__F1 Mechanisms by which radiation enhances immunotherapy 140885 961 3146 115004 940 PMC6423768__F7 A schematic diagram of exosomal miR-128-3p based signaling pathway in CRC treatment 648 7291 999 2146 PMC6430251__F1 Schematic diagram to illustrate the activation of the nuclear factorKB (NFKB) pathway in the radiation-induced rescue effect (RIRE) 7186 675 5970 PMC6430496__F2 Underlying molecular mechanisms of ZFAS1 in multiple human cancers 27161 4323 4325 2146 10365 85409 PMC6437734__F6 VPA induces apoptosis in neutrophils and diminishes their phagocytic capacity 2358 581 100187761 PMC6438767__F7 Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure via Sirt1/mTORC2 and AMPK Signaling 23411 253260 2308 PMC6441195__F3 Exo-circRNAs play a crucial role via their sponging function and can be secreted into body fluid in tumors 346389 63976 7874 2146 890 PMC6445936__F7 Highlights of this study 2530 613 969 PMC6447179__F9 Traumatic brain injury induces long-lasting changes in immune and regenerative signaling 285 6720 3726 3958 6387 2920 4256 59307 467 2353 1958 6348 5328 2335 3162 2171 PMC6449624__F2 BTLA-associated signaling pathways (stimulatory/inhibitory) regulate the outcomes of HBV-ACLF, liver graft tolerance/rejection, liver cirrhosis and hepatocellular carcinoma 11126 151888 2885 619501 PMC6453877__F4 HIF-mediated regulation of mitochondrial mass 5442 7019 664 4601 PMC6456554__F7 Schematic representation of the outlined hypothesis 19 22937 3949 PMC6456803__F1 Vitamin D pathway 1717 8029 5741 8074 4036 7421 1628 1591 1593 7054 PMC6457711__F2 Regulatory mechanism of calcium on HIF1A induction 6786 90550 79054 7226 7225 7220 2475 10399 PMC6458732__F6 A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions 3667 3569 2475 6774 PMC6461988__F4 Reconstructed key metabolic pathways of Thermoprofundales based on eight MAGs (a) 65057 4099 1431 2271 2184 5185 PMC6462347__F5 Schematic overview of the folate metabolic pathway mediated by FOLR, DHFR, and MTRR 1719 2271 2618 4548 4552 PMC6463957__F5 Hub genes and module analysis of the PPI networks 7057 6678 1301 1281 2335 1300 1289 1278 1277 80781 871 283208 1284 5054 87 7366 192134 4586 3678 3671 1562 216 4582 4588 131 2650 5267 7076 218 220 PMC6468358__F1 ADRB2 signaling in prostate cancer 154 7408 4170 572 PMC6468848__F3 Functional effects of Notch-regulated miRNAs in glioblastoma 4851 4853 7405 10683 PMC6469084__F7 Relationship between USP6NL and the pathway 9712 1499 595 PMC6470053__F9 Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments 3024 3009 149041 PMC6473842__F2 Signaling pathways in mDA neuron development 6469 9241 2261 2260 2263 84133 4040 4041 340419 55366 8549 7471 7976 27122 6608 8643 5727 1499 2736 2118 1848 2735 627 4009 5309 5087 2737 PMC6476530__F1 Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy 51719 7248 1032 1030 7249 2475 999 5347 PMC6476857__F12 Graphical abstract shows the protective mechanism of SFN against Ar-induced damage in the kidney tissue via PI3K/Akt-mediated Nrf2 signaling pathway 367 2810 847 9817 PMC6484007__F1 STIL: a multi-function protein required for dopaminergic neural proliferation, protection, and regeneration 6469 2735 6608 51684 6491 PMC6485631__F1 CD69: from activation marker to metabolic gatekeeper 969 3718 3717 341567 PMC6487791__F2 Representative working modes of mutant p53 GOF 1019 5300 4087 4088 387 23657 7295 PMC6490153__F6 Pathway summary of a host defense mechanism response to bacterial meningitis caused by Streptococcus pneumoniae 5925 627 581 PMC6491894__F1 Deletion of both cytosolic superoxide dismutases impacts metabolite concentrations and enzyme abundance of TCA cycle (A), glycolysis (B), and pentose phosphate pathway (C) 101448070 11113 4118 22934 6120 6390 6389 6392 6391 PMC6496424__F1 Multiple mechanisms involved in the protective roles of NLRP6 in intestinal epithelial cells 4615 4583 171389 1234 3569 3606 6352 50616 PMC6497364__F4 MiR‐125b‐protein and protein‐protein interaction network of differentially expressed genes, with particular focus on AHSG (fetuin‐A), FGF‐23, and TNFRSF11B (osteoprotegerin) 4055 4049 5054 197 8792 329 7124 330 5970 5328 8074 2768 2778 2776 27040 4050 4982 PMC6497964__F8 The signaling pathway from EPHB6 to catecholamine biosynthesis in AGCCs 2051 367 1947 2002 1958 7018 7054 PMC6498735__F1 Regulatory pathways leading to stem-like cells underlie prostate cancer progression 79923 4609 3169 960 PMC6500894__F2 Mesenchymal stem cells and their mitochondrial transfer: a double-edged sword 9242 7127 4922 PMC6503643__F5 HSVs interfere with antiviral processes in innate immune cells 51604 115004 2821 912 100507436 7097 7096 10333 29110 PMC6509080__F2 Mechanistic pathways underlying reverse cholesterol transport from macrophages to liver 348 9619 19 3931 5360 1071 7038 3949 PMC6510997__F1 Immune signaling network in MS 4915 114609 1616 3458 6714 5970 3630 3643 3725 3315 2353 PMC6514059__F2 Expression of the NCRs and their Ligands 5111 4811 3600 3558 5199 PMC6514668__F1 Schematic representation of the autophagy pathway from reference by Seiliez et al 9140 9474 10533 83734 64422 PMC6514876__F10 Model outlining biomarkers and pathways between CTCs and PMN-MDSCs interactions (CTC/PMN-MDSC cluster) isolated from blood of metastatic cancer patients 6997 4838 4851 PMC6515249__F2 Negative regulation of the TRAIL-driven pathway 6788 148756 7189 83737 PMC6515458__F1 MicroRNA-regulated networks in muscle wasting during cancer cachexia based on meta-analysis data 9021 2660 6774 3726 4208 857 84676 114907 6387 664 2308 2908 23710 PMC6520274__F1 Hydrogen sulfide intervention in cystathionine-Beta-synthase mutant mouse helps restore ocular homeostasis 635 4397 4548 875 1431 PMC6520728__F6 Schematic diagram for a proposed molecular mechanism of CFH regulation in lung cancers 8651 9021 6775 3075 PMC6520938__F2 Canonical Notch signaling pathway 5045 595 1026 PMC6523352__F2 Heme activator proteins (HAP) complex 4190 641371 65003 64976 4485 3417 1537 9377 730 729 735 1355 84987 1353 1352 PMC6525355__F1 Metabolic engineering strategies for producing PPD from xylose 1756 7498 3652 7054 PMC6528674__F1 Non-canonical Hippo signaling in the regulation of leukocyte function 4485 9113 26524 PMC6528674__F3 Non-canonical Hippo signaling in the regulation of leukocyte function 4088 6774 4485 79958 50943 3605 5872 PMC6528674__F4 Non-canonical Hippo signaling in the regulation of leukocyte function 7096 4485 7097 8011 7099 4615 5873 PMC6529853__F5 Dysfunctional subpathway (path:04020_1) of calcium signaling pathway in CESC 6865 1909 9630 1910 5737 552 PMC6530647__F4 Carbon monoxide controls metabolic homeostasis via the PERK-eIF2Alpha-ATF4-FGF21, SENS2, and REDD1 pathway 83939 468 26291 83667 PMC6533072__F3 Estrogen biosynthesis pathway 1583 3284 1586 3292 1588 PMC6536719__F5 EGL-9 inhibits the HIF-1 target NHR-57 from reducing RAS/MAPK signaling through a DELTA/NOTCH-induced negative feedback loop 1950 1956 112399 PMC6538876__F1 Potential implication of proprotein convertase subtilisin/kexin type 9 (PCSK9) in amyloid B (AB) clearance in Alzheimer’s disease (AD) 19 255738 4035 348 948 PMC6539061__F2 Polycystin-associated pathogenic mechanisms in human diseases 6772 6774 3717 860 PMC6539587__F1 Sequence information of the overexpression vector HIF-1Alpha-pcDNA3.0 80320 54820 100187761 PMC6539991__F3 Pathway networks 100187761 8190 5901 5053 PMC6539991__F5 Sub-molecular network of CC, EC and VC 7422 2247 596 890 983 3479 PMC6540516__F8 Evolution of erlotinib resistance in CD166+ OSCs 1956 7291 6935 PMC6541606__F7 Human mesenchymal stem cells promote tumor growth via MAPK pathway and metastasis by epithelial mesenchymal transition and integrin A5 in hepatocellular carcinoma 3569 7124 3678 PMC6543531__F8 Regulated Necrosis and Failed Repair in Cisplatin-Induced Chronic Kidney Disease 5624 9423 3934 3084 5366 5467 94241 3745 2048 54756 4092 2353 1026 PMC6544834__F1 Progress in the Management of Malignant Pleural Mesothelioma in 2017 5728 4771 2146 8314 7157 4193 PMC6545067__F6 Graphic conclusion 8091 1499 595 PMC6549095__F7 Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NFKB expression 558 2621 4313 4318 PMC6549764__F3 15d-PGJ2 regulates adipocyte differentiation and osteoblast differentiation via a PPARGamma-dependent pathway 9242 860 1499 PMC6557283__F1 YAP/TAZ signaling and resistance to targeted therapy 1956 2885 4771 4485 29110 79817 9113 26524 6935 23476 7003 8463 7004 7005 558 2065 PMC6558915__F10 Schematic presentation of the anti-TNBC mechanism of Ilamycin C 142 4318 4313 6774 581 3717 PMC6562797__F6 Flaccidoxide-13-acetate-induced apoptotic pathway in bladder cancer cells 572 581 83939 468 3024 PMC6562901__F1 TGFB Signaling 4087 4088 2475 4089 PMC6563035__F1 PD-L1 reverse signaling in tumor cells and macrophages 941 942 3458 PMC6563119__F4 Roles of the Hippo pathway in effector T cell differentiation 3458 50943 4485 324 920 PMC6567317__F2 Known mechanisms and signaling pathways involved in histone deacetylase inhibitor-activated induction or suppression of autophagy 2475 4193 10533 842 PMC6579679__F8 Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart 57216 4087 4088 387 4089 PMC6580874__F3 Simplified schematic of the PI3K pathway, which highlights the common targets for small molecule inhibitors 5163 3667 5728 253260 2475 4193 10397 675 PMC6584781__F1 Signaling pathways that converge on p38 mitogen-activated protein kinase (MAPK) activation and formation of plexiform-like lesions in pulmonary arterial hypertension (PAH) 7038 7247 6774 2002 4318 7424 PMC6591252__F8 The proposed model for the scaffolding role of the IQ3 motif in IQGAP1 towards the PI3K-Akt pathway 1956 1950 5163 8826 PMC6592229__F1 Balancing DNA double-strand break (DSB) repair.Homologous recombination repair (HR) and classical non-homologous end joining (cNHEJ) are orchestrated in a balanced DSB repair response 672 9156 7518 5888 675 PMC6592229__F2 Inhibition of DNA end resection promotes cNHEJ.DYNLL1, shieldin and UBQLN4 inhibit DNA end resection thereby promoting DSB repair by cNHEJ 56893 672 4361 8655 55183 9156 7518 5888 675 PMC6592248__F8 Proposed model to explain the molecular mechanism of Bmal1 deficiency influenced the HIF1Alpha-VEGF axis in the chondrocytes 406 9575 1407 5091 PMC6598324__F7 The potential mechanism of FOXP3-mediated regulation of cancer cell stemness 50943 100507500 4851 3280 PMC6599063__F4 Simplified schematic representation of the affected pathways in an emerging honeybee worker that impact Varroa and DWV symptoms via their interactions 6955 4087 4088 5879 2475 604 PMC6602878__F3 GDNF expression in Sertoli cells 3714 182 4855 4851 4854 4853 3516 100188776 PMC6606008__F4 Hippo Pathway for tumor suppression 4485 9113 26524 9686 PMC6606846__F2 Regulation of (p)ppGpp metabolism in Gamma-proteobacteria 5970 4553 3250 PMC6610018__F4 Cross talk between the cGAS-cGAMP-STING pathway and autophagy/mitophagy 115004 8408 65018 8878 10133 29110 PMC6611507__F4 Emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications 4609 6362 4843 1950 920 PMC6611727__F3 Caspases in cell death, inflammation and disease 7124 7186 8717 8737 11035 114548 8772 841 581 81030 23118 257397 197259 79792 840 836 842 834 PMC6611790__F5 Hypothesis of the mechanism of IDH mutant gliomas 8424 54790 5091 PMC6611921__F4 Pathway map based on renal age-associated gene (RAAGs).Enriched molecular pathways based on the set of 634 RAAGs are displayed 6372 4982 7124 1950 3710 2475 629 718 PMC6613304__F5 Nicotinamide Adenine Dinucleotide (NAD+) Biosynthetic Pathways 23475 130013 64802 349565 23057 65220 27231 10135 54981 PMC6614345__F2 Differentially expressed miRNAs in thyroid cancer tissues modulating the PI3K pathway 7903 2885 5728 4282 2475 PMC6614373__F1 Pathogen-Responsive NFKB 3458 7099 4615 3716 3717 6772 929 PMC6616296__F10 Proposed mechanism of the p75NTR as a mediator of synaptic changes during SD 387 9475 627 PMC6627250__F1 Neoplastic transformation of melanocyte 673 5728 7015 4893 4311 4286 55294 6774 6678 1029 11201 344022 PMC6627707__F1 Biogenesis of extracellular vesicles (EVs) carrying micro RNAs (miRNAs) in viral infection 967 975 928 PMC6628314__F1 Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer 1956 3084 9542 10718 145957 6714 5728 PMC6628600__F5 UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression 1356 2475 51378 29909 PMC6628717__F3 ErbB-2 Downstream Targets to Promote PCa Tumorigenicity 2885 5728 367 PMC6628971__F1 Molecular mechanisms of the cGAS/STING pathway as a senescence-associated DNA damage sensor and inflammation trigger 3661 29110 115004 6120 PMC6629960__F1 Air pollution and ultraviolet radiation (UVR) on the skin 5053 1545 1543 196 PMC6630988__F2 Herpesviruses modulate the JAK-STAT pathway 3459 3455 3454 163702 3460 3716 7297 3717 6773 10379 3659 PMC6635068__F1 Rb pathway loss and assays for their detection 5925 1021 1019 595 619537 1029 7018 PMC6635453__F5 Proposed pathway for RQ biosynthesis in C 27235 51004 51805 84274 PMC6637848__F7 Cell signalling events that mediate the switch between self-renewal and differentiation in mouse embryonic stem cells 652 2249 3976 2885 6774 2475 1852 5163 3397 PMC6638267__F8 Working model for the role of peroxisomes in fungal infection 553115 5190 5194 5830 5191 PMC6640082__F1 Mammalian Heme Synthesis Pathway 212 3145 2235 5498 7390 7389 PMC6642076__F1 The complement system, showing approximately 50 directly involved soluble and membrane-bound complement proteins 1401 718 712 1378 4153 5340 5648 716 720 727 7448 730 729 735 717 PMC6651423__F2 Mechanism of Activation for the Non-Canonical and Alternative NLRP3 Inflammasome Pathways 114548 7099 4615 8737 8772 140609 PMC6652202__F4 Protein-protein interaction network 5728 60 6895 PMC6652233__F3 Stimulation of TLRs activates multiple signaling pathways 4615 929 7098 7189 3661 7099 7100 PMC6653805__F6 Autophagy in Adipose Tissue Physiology and Pathophysiology 7099 10533 3553 9140 3920 3916 9474 114548 PMC6662580__F1 Hippo pathway 4771 122786 23286 5524 6788 6789 57551 60485 166824 11186 999 9113 26524 23513 84962 92597 55233 23558 5784 8945 5499 7159 1452 7529 7531 54882 26057 1495 10207 28996 92359 154796 PMC6664756__F4 Predicted mechanisms of ELF1 regulation of doxorubicin-induced apoptosis 472 1869 9670 9759 79035 24144 57109 578 596 283373 255043 9775 PMC6664910__F10 Schematic diagram of LIM kinase-dependent inhibition of n-cofilin activity by Reelin 1600 2932 2475 PMC6666404__F4 Longitudinal multi-omics of host–microbe dynamics in prediabetes 3586 7454 6955 367 759 2744 4137 1674 351 6622 10763 7038 PMC6671812__F12 Proposed model of IL-18-mediated microglia/astrocyte interaction in the spinal cord 7099 10068 627 PMC6671871__F1 Lignin biosynthetic pathway 1312 790 57608 PMC6678221__F1 Role of the canonical Wnt/Beta-catenin pathway in cancer metabolism 4040 4041 324 6319 1499 PMC6680919__F4 Leptin signaling 6774 181 5443 7173 PMC6681775__F8 Regulatory mechanism of AQP1 in endometriosis 358 7471 54361 PMC6683488__F1 Molecular landscape of SCLC 4609 6790 7465 6772 5925 6774 3659 472 545 1869 91607 2146 429 PMC6689553__F4 Proposed metabolic pathway of the relevant eicosanoids 246 2879 260431 2876 PMC6690701__F8 Several H2S-sensitive metabolite changes map to redox active nodes in central carbon metabolism 2597 2805 4118 PMC6693056__F16 Summary of key estrogen-dependent mechanisms in endometriosis 3553 7536 2627 3294 PMC6695538__F1 The crosstalk between estrogen receptor and growth factor receptor intracellular signaling pathways 595 1019 2475 PMC6695732__F6 Model of ESRP1-mediated cell cycle G1-phase arrest 54845 890 991 PMC6700212__F1 Dual sequential cell death checkpoints in the TNFR1 signaling pathway 8717 8737 7186 1540 11035 8772 197259 7124 PMC6700737__F1 MiR-126-orchestrated regulation of pDC effector functions in lymph nodes undergoing an immune response 7249 7248 2475 54106 3665 5132 4615 PMC6700826__F7 Putative regulatory pattern of PoSet1 and PoSet2 on cellulolytic enzyme gene expression 1283 4199 4200 10873 7018 PMC6701977__F3 Adenocarcinoma genotypes encode for transformation via the Ras pathway supported by the calcium pathway and the integrator complex 3709 7124 3117 3119 406985 1027 1432 6660 406933 100126314 1026 10635 5558 PMC6705132__F7 Schematic model for BA-TPQ-induced MCF7 cell apoptosis 467 3725 1649 PMC6707123__F2 Schematic representation of the neural circuitry underlying the control of circadian rhythms 140805 3535 4852 594857 PMC6707807__F1 Enriched immunological pathway and genes 9902 10381 6890 30845 3134 3107 2263 3135 3106 8976 3133 116987 9436 8743 7535 53358 2534 PMC6708252__F1 Interactions between VHL, HIF and the NFKB signaling pathway 7428 1950 331 7124 PMC6708892__F4 The mechanisms involved in the transformation from NSCLC to SCLC 1020 5925 7157 4609 PMC6709694__F4 Integration of HTS and CTD informs disease-pathway connections 4117 7054 275 7124 PMC6710335__F8 The working model of Tpl2 in protecting against fulminant hepatitis 2920 2919 64806 920 PMC6714586__F1 Main signaling pathways implicated in VE-cadherin/VM-positive cells 8829 790 595 7481 PMC6715590__F1 NLRP3 inflammasome activation pathway 3553 7099 114548 3603 PMC6719047__F2 RTT-related protein known functional interaction networks 8911 23221 23314 3785 10472 6326 9612 8295 9568 7543 4208 1108 253639 9455 PMC6721423__F1 PTEN-mediated control of cancer stem cells (CSCs) hallmarks 3570 7852 406952 6275 406998 406982 406903 406985 5728 406991 406900 407006 407007 648 10419 3569 6774 2475 2932 4128 5081 847 PMC6721501__F1 Figure depicts canonical hedgehog signaling pathway 3549 50846 6608 51684 2735 2736 2932 2737 6469 PMC6721501__F2 Figure depicts pathways that cross-talk with Hh pathway leading to its non-canonical activation 1950 4089 2475 2932 6608 1499 2735 1956 PMC6721565__F3 LRP6 and WNT/Beta-catenin pathway alterations in epithelial cancers 4040 22943 54894 324 1499 100505633 84793 PMC6723230__F2 Representative miRNA-gene network interactions between the genes with an altered expression levels when comparing tumor to normal tissue and their respective miRNAs, generated using miRNet 6382 2737 5366 3486 2619 9672 1026 894 1643 596 595 6241 3569 650 3675 367 6319 27113 64399 3479 375790 960 64065 6385 54361 7481 2810 8643 PMC6723754__F3 Signaling pathways elicited by stabilin-mediated phagocytosis of apoptotic cells 51454 5879 1398 1793 PMC6727741__F8 WDR92 in the axonemal dynein assembly pathway 79657 8607 10963 10856 55172 6674 55011 120379 8161 PMC6728578__F9 Key proteins involved in the DNA damage response (DDR) following DNA double-strand breaks (DSBs) 10111 4361 3014 9656 545 672 472 PMC6731276__F1 Pathway altered on both transcriptomic and epigenomic levels 7432 5443 797 3972 153 3274 10203 3362 4158 4160 5739 54331 2788 324 116 PMC6733417__F2 Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets 655 3082 28999 4087 4088 2475 PMC6734087__F2 Canonical transforming growth factor (TGF)B and noncanonical pathways in endothelial to mesenchymal transition (EndMT) 7939 4091 4092 4088 4087 4089 2475 6615 6591 7291 1003 59 PMC6734087__F3 Diagrammatic representation of other pathways involved in endothelial to mesenchymal transition (EndMT) regulation 7939 857 27035 50507 4089 4088 4087 3091 6615 59 1003 PMC6736526__F3 Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect 4760 5629 4851 761 PMC6738049__F1 Illustration summarising the major tumour procoagulant effects in pancreatic cancer 7018 10855 10630 7035 PMC6738049__F2 Haemostasis and fibrinolysis 7018 8000 7035 5340 PMC6738120__F1 BRAF pathway 1956 2885 673 5728 2475 PMC6738663__F2 HMGB1, as a priming signalling, involved in the stress-neuroinflammation-mesolimbic dopaminergic pathway 3146 627 3553 114548 PMC6745167__F2 Results of network analysis: differentially regulated proteins from the SILAC approach are indicated in green (TCam-2) or in red (NTERA-2) 10637 1312 249 3479 2064 1950 2065 126669 1956 5834 7054 8836 4059 PMC6745301__F2 MicroRNAs and Regeneration in the Animal Models of CNS Disorders 4086 253260 6009 4090 PMC6751266__F1 Overview of microRNA-27a biogenesis, highlighting key enzymes in miRNA biogenesis 29102 54487 57510 PMC6751266__F2 Brief conclusion of miR-27a in regulating cell signal pathways Panel gray, miR-27a can regulate Ras/MAPK/ERK pathway to active key gene such as c-myc 1499 1950 2932 4087 4088 55294 4089 23035 4091 2308 PMC6752849__F10 Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor 2932 196 1499 PMC6752985__F1 PI3-K/Akt signaling pathway 5163 5728 1017 7249 PMC6754502__F5 Broiler thymus predicted to have less cell migration in response to the Thermoneutral + LPS treatment compared to Fayoumi 7077 1903 388 1435 2022 335 1755 PMC6768854__F7 MiR-708 expression gradient is reduced during the transformation from normal prostate epithelial cells through adenocarcinoma cells to NEPC 100126333 1499 6925 983 2146 143686 2308 PMC6769035__F1 Tumor microenvironment shapes NK cell metabolism and effector functions 2475 2203 367 PMC6769793__F4 Metabolic pathway of classic and non-classic androgens 1583 5447 3293 8644 3284 3283 1586 1584 3294 6715 3291 6716 PMC6769940__F1 Interference of hepatitis C virus (HCV) with the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)/ Keap1-signaling pathway 3479 3480 3667 8660 2475 1571 30001 9817 4094 PMC6770025__F1 Synthesis of steroid hormones in humans 6770 3284 1589 1586 5447 1588 3294 3292 6716 PMC6770221__F6 Mechanism of optimal therapeutic drugs in each subtype of breast cancer 673 5894 3791 5159 3725 28 PMC6772763__F8 Multiple signaling pathways regulate the cell death pathway in sympathetic neurons 4803 581 3725 PMC6775198__F3 Effect of WNT signaling on cancer immunosurveillance 6351 50943 55509 7018 PMC6776600__F11 Complement inhibitors target different levels and steps of the complement cascade 1356 10747 718 PMC6780086__F6 Transcriptional profiling of enzymes involved in type II fatty acid synthesis (FASII), glycerolipid synthesis in plastid (GLSp) and cytosol glycolysis (GLSc), and beta-oxidation 51083 4099 5091 7038 355 PMC6781449__F10 Kindlin-3/leupaxin complex regulates paxillin tyrosine phosphorylation and podosome stability 2147 2152 3982 PMC6781492__F4 Bioinformatics analyses for the top two negatively co-expressed hub modules of SNHG7 in thyroid cancer 4591 6049 9690 10075 23304 4734 51088 996 55958 7428 197131 9867 83737 8139 11059 54778 26046 27252 9320 55236 25831 7328 4905 9871 10802 23122 2804 3796 140735 57511 10466 22919 5527 5529 5903 5048 23063 9527 6711 10274 8243 546 10427 5591 6595 64083 545 5965 5290 10111 7158 2072 5980 5266 PMC6781720__F1 Schematic overview of the TLR4 signaling pathway 3929 929 4615 7099 51135 3656 7189 PMC6781988__F8 Proposed mechanism of miR-125a-5p function in HCC 5770 4296 581 PMC6785146__F3 Mechanism of alterations in the TSPO-mediated mitophagic signaling pathway and NLRP3 inflammasome activation in bipolar disorder 706 6774 65018 3553 3606 PMC6790574__F1 TLR‐mediated signaling pathway 4615 3656 51135 7187 29110 3661 3458 3586 3565 7099 54106 51284 51311 7098 PMC6790574__F3 Nucleic acid sensors 115004 3661 29110 PMC6795080__F1 Mevalonate pathway intermediates active in feedback control 2222 1718 1595 7108 3930 6307 50814 51478 PMC6797170__F4 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach 5447 4117 2444 7276 629 183 3929 2243 2268 1356 2266 324 3273 6955 1431 197 350 7939 PMC6797510__F10 HOTAIR competitively binds to miR‐206, thereby promoting STC2 expression, activating PI3K/AKT signalling pathway 100124700 27161 8614 PMC6798117__F9 Model depicting the effects of ZIKV infection on cell cycle progression in hNPCs 472 545 993 PMC6801718__F10 Summary of data showing TGFB1 recruitment of miR-143 and miR-145 to RISC to destabilize CFTR mRNA and impair the corrector/potentiator-mediated rescue of F508del-CFTR 1080 7040 4088 27161 PMC6803550__F7 Model illustrating metabolic processes 174 5091 55364 2475 PMC6803663__F1 Flow diagram illustrating the molecular methodology and frequency results of CRC cases diagnosed between 2011–2012 4292 5395 4436 2956 PMC6805653__F10 Molecular mechanism of miR-129-5p regulation of ZIC2 expression and the Wnt/Beta-catenin signaling pathway in PCa 7546 999 1499 1000 PMC6812177__F1 Proposed mechanisms of inflammasome involvement in RTT OxInflammation.The scheme summarizes the basal and LPS + ATP-stimulated status of the inflammasome pathway by comparing the responses of CTR and RTT fibroblasts 114548 834 3553 PMC6822710__F1 Mck1 kinase is a new player in the DNA damage checkpoint pathway 6055 6054 4550 6053 5954 990 PMC6826402__F1 Proteomic workflow for the investigation of molecular determinants of acquired resistance to cetuximab 6717 3939 1398 2317 7408 5829 4026 1956 6714 6311 2048 157313 6386 378 6273 4397 3728 79026 1829 5970 1832 23164 51599 1445 10097 226 192 6175 PMC6826893__F5 Crosstalk between RAS-ERK pathway and FOXM1 2305 7054 6502 1843 11221 PMC6826966__F2 Mechanism of resistance to arsenic trioxide- all-trans retinoic acid (ATO-ATRA) therapy in APL 5914 5371 2475 7124 2322 7704 54880 2147 PMC6826993__F2 After co-culture between adipocytes and breast cancer (BC) cells, high levels of miR-144 and miR-126 were released by exosomes by BC cells 3667 6774 56729 5352 3952 7124 6714 79923 2475 6662 PMC6828748__F4 Molecular pathway linked to oxidative stress response in E 11047 5708 107966124 PMC6829074__F2 microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways 100302274 4615 3654 51135 7189 10068 PMC6834162__F4 MTX affects several signal transduction pathways implicated in the pathogenesis of rheumatoid arthritis (RA) 3558 3600 3458 3553 PMC6835115__F3 Targeting PKCι-PAK1 in EGFR-mutation positive non-small cell lung cancer 558 1956 64866 3717 6714 5879 5058 6774 1894 10413 PMC6835793__F1 The CD40-ATP-P2X7pathway links cellular responses in Müller cells with the induction of inflammatory responses in bystander microglia/macrophages in DR 958 3553 6347 4843 3383 PMC6836336__F3 GREM1 expression is associated with genes involved in collagen formation and extracellular matrix (ECM) organization 649 27286 5396 1513 8038 81792 10631 6876 4060 50507 2246 7130 3624 253827 4313 7058 23452 83468 2335 1809 2191 4015 115908 10630 6678 283208 165 169792 9509 84251 1462 2295 5919 2200 4323 4017 PMC6836530__F8 Schematic diagram of the molecular mechanisms underlying NOTCH2-regulated EMT 4853 7189 999 PMC6838750__F2 Main processes involved in exercise-induced and neurotrophin-mediated increased viability of dopaminergic neurons 7054 596 581 PMC6839745__F1 Structure and treatment strategy of TAT-CLs-DHA/siRNA 7099 4615 3146 3553 PMC6842518__F5 Proposed model depicting the underlying molecular mechanism by which aqueous bark extract of T 948 22926 1843 7494 PMC6850169__F1 Simplified lipid metabolic pathway in maize 355 4018 10724 907 4099 283871 PMC6850919__F8 Resveratrol (Res)‐mediated suppression of ALI through STAT3/SOCS3 signalling 23411 6774 9021 PMC6854620__F7 Running young is more effective than running at midlife 4323 7422 4851 3910 3911 3908 3913 10319 PMC6855007__F10 Illustration representing the mechanisms of compound 1-induced human breast cancer cell apoptosis 545 472 572 637 1956 PMC6857641__F1 The tryptophan catabolism pathway 3620 6999 8942 8564 PMC6857659__F1 TGFB signaling pathway and its role in tumor immune microenvironment 4087 4088 50943 4615 3397 6367 PMC6857900__F2 Simplified Version of the Canonical Wnt/ Beta-Catenin Pathway 324 2932 1499 PMC6858516__F1 Towards precision oncology in advanced prostate cancer 367 11200 472 675 51755 7157 5925 1021 1019 PMC6858516__F3 Towards precision oncology in advanced prostate cancer 367 5728 2289 PMC6858516__F5 Towards precision oncology in advanced prostate cancer 1021 1019 5925 1017 PMC6858516__F6 Towards precision oncology in advanced prostate cancer 5925 6790 2146 6657 367 PMC6863919__F5 Metabolic reconstruction of “Ca 2805 3652 51228 5132 PMC6868788__F8 Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway 56957 595 4313 1017 4318 PMC6873421__F2 MET amplification causes EGFR-TKI resistance by activating EGFR-independent phosphorylation of ErbB3 and consequent downstream activation of the PI3K/AKT pathway, providing a resistance mechanism that can bypass the effects of an EGFR-TKI 1956 2065 5163 5164 PMC6876322__F4 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis of the target genes of CTD-2357A8.3 in HNSCC tissues 91010 30837 11040 2821 2050 79834 7804 4478 6728 7013 10628 200539 2932 81611 6787 7832 7517 7037 6774 10397 2296 4841 396 4150 115650 4335 331 147687 54440 7562 55095 84124 79673 5966 6356 3949 23181 1870 10389 23550 644150 4193 94 7170 8463 677 7171 84458 8085 7477 4804 143686 27173 5547 7476 2185 2342 4298 22835 7621 116987 7021 51006 91 6426 6519 PMC6878846__F1 Hereditary systemic autoinflammatory diseases and Schnitzler’s syndrome 7124 8737 8717 90268 4615 7186 51135 3654 7189 23118 10454 PMC6880770__F6 Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways 100187761 47 23013 2353 33 7054 1636 4597 10654 9118 3030 3033 51083 PMC6884928__F2 Phosphatidylinositol 3-kinase (PI3K)/pAkt-kinase pathway as a central CCL5/CCR5 signalling cascade in cancer cells 1234 6714 5728 PMC6885362__F3 Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells 5879 7124 54472 114609 3569 8772 100379198 3929 929 23118 4284 51135 7189 920 941 1513 130749 3661 29949 958 923 PMC6885365__F4 Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis 54187 1674 2934 35 4357 4000 PMC6886443__F5 Proposed model of (defective) AP-3 dependent acquisition of VAMP8 during Weibel-Palade bodies (WPB) maturation 8673 967 7450 PMC6886699__F9 Adenoviral Transduction of EGFR into Pregnancy-Adapted Uterine Artery Endothelial Cells Remaps Growth Factor Induction of Endothelial Dysfunction 7422 2885 7222 6714 1956 1950 PMC6887951__F4 FGFR pathway and dysregulation in cancer 10818 2885 2549 PMC6888459__F3 Intracellular trafficking of EAAT3 5174 8650 57537 PMC6889286__F2 Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer 1956 2261 4914 673 238 5979 6098 558 5728 6774 2475 PMC6891198__F7 ALK and RET inhibitors promote HLA class I antigen presentation and unmask new antigens within the tumor immunopeptidome 238 5979 6772 PMC6894260__F1 Wnt/Beta-catenin signaling pathway 4040 4041 55366 1499 54894 84133 324 22943 PMC6895193__F6 As a tumor-suppressor gene, RASSF1A mainly acts as a crossroad of three intertwined molecular signaling mechanisms including Ras/Rho GTPases, MTs, and Hippo pathway 83593 64112 4131 55201 2475 10013 6010 PMC6895808__F1 Progression of thyroid cancer and the main genetic alterations involved in such process 7849 5468 673 5979 5728 7015 7157 1499 PMC6895975__F2 Extracellular regulation of mesendodermal gene expression 4693 652 199699 4838 4089 PMC6896143__F4 A diagrammatic representation of the pathways that can indirectly lead to inhibition of apoptosis in a cancer cell 6774 3716 1499 3082 PMC6901795__F7 A schematic model of zbTRIM25-mediated RLR signaling pathway during RGNNV infection 23586 57506 7189 7187 7706 29110 3661 PMC6903391__F3 Epigenetic changes induced by iAs 4397 4524 635 875 1491 57412 PMC6905042__F2 Proposed mechanisms of Wnt/Beta-catenin dysregulation in ovarian cancer 219771 1499 901 83595 8658 51552 8629 84133 54894 4040 4041 999 PMC6908928__F9 Gene network describing the possible mechanism of the regulation by CHST15 of cell proliferation and apoptosis as determined by IPA 10055 7039 407975 7078 595 1915 3953 147495 5744 650 1390 5328 7832 80895 8615 7168 1191 51363 5366 55684 PMC6909887__F1 Mechanistic Target Of Rapamycin Complex 1 (mTORC1) signaling pathway with areas of potential pharmaceutical inhibition highlighted 652968 6009 153129 PMC6914886__F6 The proposed mechanism by which green tea acts against NAFLD 948 7099 7189 116519 2308 2181 7351 51141 3156 5465 6257 79602 PMC6916690__F2 Signaling pathways and cross talk, regulated by E-cadherin 999 1956 5879 387 2475 7124 2002 PMC6916696__F1 The diverse regulatory mechanisms of circRNAs in GC 5728 2475 1000 999 5163 PMC6917511__F2 Flow chart of the RHPCG database 4771 6418 9113 26524 7018 10413 PMC6917616__F3 Metabolic and transcriptional adaption in tissue Treg cells 90865 50943 2625 3248 196 PMC6917725__F10 Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases 8717 8772 5272 8205 PMC6918647__F3 Network analysis using Ingenuity Pathway Analysis (IPA) among 4 upregulated (a: HMGB1, HOXA13, SREBF2, MECOM) and 3 downregulated (b: NCOA2, CSHL1, HDAC5) transcription factors and differentially expressed genes due to onset of ketosis postpartum 655 650 1634 3691 63908 6498 6721 27346 123 49 10682 1622 3170 1831 2692 10468 2244 8805 10499 196 5728 PMC6925522__F2 LRRK2 and inflammatory signalling 7124 7099 641373 7189 120892 4671 1827 58484 3553 PMC6928039__F7 CR3 triggers the Syk/calcineurin/NFATc pathway upon engagement by PGL-I-producing mycobacteria to rewire the innate response 6850 4615 64170 8915 10892 7124 3603 PMC6930397__F5 Functional protein interaction network of PLOD family genes 5351 9509 1634 4060 649 9508 5118 4313 2200 6678 26577 3683 7373 10491 1281 1298 871 5479 1307 1297 6662 23127 1299 5352 8985 1303 PMC6933354__F6 Schematic model indicating that SPRY4‐IT1 competitively binds to miR‐217 and TCF7L2, consequently regulating the Wnt/B‐catenin signalling pathway to promote stemness of breast cancer cells 100642175 2932 324 102465531 1499 6934 PMC6933613__F8 Schematic diagram of IL-17A induces excessive autophagy via Src-PP2B-mTOR pathway in neurons under ischemic condition 5335 6714 2475 84818 PMC6933942__F5 Summary of proposed mechanistic pathway of S1PR1-induced mechano-hypersensitivity 1901 3603 114548 3553 7124 PMC6939459__F10 Conceptual models of mitochondrial metabolite transport and the consequence of metabolic perturbations on Th1 cell activation 11113 4118 355 7054 PMC6939830__F1 S1P-S1P receptor signaling system 388931 124976 6010 PMC6940991__F3 Mutant p53 GOF and hypoxia 387 4193 10013 PMC6942938__F1 Proteome alterations in aqueous humour of primary open angle glaucoma patients 7471 27122 11197 5879 10297 387 8312 1499 PMC6943215__F1 The ‘Metro-Rail Concept’ to targeted therapy of the pathophysiology of cirrhosis 929 3082 100188864 PMC6943653__F1 Scheme of the insulin/IGF-1 signaling pathway (IIS) in C 5163 207 6446 PMC6944218__F5 PCB153 exposure altered forkhead box O (FOXO) signaling pathway 4089 4088 1017 4485 51701 664 9140 3480 5728 3643 5163 5164 472 3575 6774 3276 10365 1950 1956 2885 5897 5896 PMC6948367__F2 Canonical STING pathway activation 115004 3428 29110 3627 6351 3661 3569 920 PMC6948370__F11 Diagramatic representation of the possible molecular mechanism of CXXC4-mediated tamoxifen resistance 80319 2932 324 1499 595 1021 1019 4040 4041 PMC6952783__F1 Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases 7189 6369 6361 PMC6952810__F2 MicroRNAs regulating key genes of the TGFB signaling pathway 7048 7046 100422969 4087 4088 4092 407009 4089 100126306 7018 PMC6953081__F2 Regulation of eIF4F complex formation by PI3K/Akt/mTOR, MAPK/MNK, and AMPK pathways and drugs targeting these pathways 27250 1977 1975 PMC6956807__F8 Proposed model for miR-204-5p-SNAI2/SUZ12/HDAC1/JAK2/STAT3 regulatory circuit in HNSCC progression 6774 3717 23512 6591 2146 999 PMC6959184__F1 The role of MYD88 signaling in normal physiology and lymphomagenesis 613 3055 3656 3654 2475 7189 5336 6774 973 PMC6960141__F10 Proposed mechanistic model of FA-97 ameliorates DSS-induced colitis against oxidative stress by activating Nrf2/HO-1 pathway 7099 9817 3553 1728 PMC6966445__F1 Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathways (simplified) 3455 7297 3454 3716 6247 6772 3459 3460 1399 10379 3665 6774 6773 PMC6966522__F2 The IL7R structure and signaling mechanism 3716 3718 2885 PMC6966530__F11 Effect of tyrosine phosphorylation of PDHK1 and PKM2 on the fates of pyruvate and acetyl-CoA in normal and cancer cells (modified according to ) 3939 5132 47 2194 2885 5163 PMC6967775__F1 Synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas 1950 1956 2475 PMC6970023__F1 Concept of the tubal precursors 6491 57534 545 472 PMC6970631__F1 Key CSC signalling pathways Notch, Wnt, and Hedgehog 28514 54567 10683 2932 324 1499 PMC6970631__F3 Key CSC signalling pathways TGFB, JAK/STAT3, and NfKB 6774 100 132 PMC6971376__F4 Pleiotropic role of miR-486-5p in manipulating several target genes in different cellular contexts.miR-486-5p has several targets in different malignant and non-malignant conditions 10562 5326 5756 9846 1793 5728 4087 2200 PMC6975965__F4 ERBB2 signaling depicting actionable targets 2065 1956 2064 2475 5163 PMC6976905__F7 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/Beta-Catenin Signaling Pathway in GC 8322 1499 100128893 2146 595 PMC6978262__F1 Signaling transduction pathways of regulating autophagy 2475 8408 54822 PMC6981617__F2 General metabolism and elemental sulfur-mediated cellular responses in Palaeococcus pacificus DY20341T 847 353 5447 759 283871 5640 2242 126669 157739 100187907 PMC6981772__F2 Plant sterol and cholesterol metabolism 5244 348 4023 39 79135 3931 PMC6983753__F5 Likely pathogenic mutations restricted in the metastases affect DNA methylation and transcriptional repression signaling pathway 1786 1789 1788 79595 1108 1107 10284 9112 8819 25942 8932 53615 5928 5931 9219 3622 57504 PMC6983994__F4 This study showed that after 24 hours of treatment with YM155, the miR-9 expression levels increased significantly compared to control cells; in addition, the expression of two target genes, including MDR1 and SIRT1, decreased significantly 9839 596 23411 PMC6985072__F6 Working hypothesis 1950 1956 2444 PMC6986441__F3 Canonical pathway (Modified from IPA) for Dopamine Receptor Signaling [−log(P-value) = 2.97; Z-score = 1.89] 1132 1312 1128 2668 9607 3902 3952 116 50632 4192 5741 6447 4986 5798 5443 PMC6986441__F4 Canonical pathway (Modified from IPA) for Serotonin Signaling [−log(P-value) = 2.04; Z-score = NaN] 2643 6697 1644 PMC6986459__F1 Landscape of USP7 targets and modes of action.(a) The USP7–MDM2–p53 axis 7874 6737 4193 367 8833 4303 5728 4851 PMC6991638__F7 Inhibitory effect of WKYMVm on osteoclast formation and bone resorption activity 928 6774 2358 PMC6991964__F8 EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria 6347 7124 4049 1003 3383 1969 PMC6992891__F1 Effect and regulation of the NLRP3 inflammasome during renal fibrosis 4087 4088 4089 114548 3553 PMC6993488__F3 Inhibiting T cell activity causes anti-PD-1/PD-L1 immunotherapy resistance 952 5728 7124 PMC6996551__F1 Cyclin D1–CDK4/6–RB and PI3K/AKT/mTOR pathways in BC 1956 7249 2475 595 1019 1021 PMC6997384__F2 Erythropoietin and its derivatives: from tissue protection to immune regulation 7099 54106 2056 942 7097 7175 4615 3654 3717 7189 3553 8651 6774 PMC7000431__F1 Human and mouse bile acid synthesis and conjugation 1593 1582 9420 4280 PMC7001271__F1 GPI biosynthesis pathway 93210 27315 5281 54872 84720 94005 10026 128869 51604 8733 9488 23556 55650 80055 93183 54965 65258 284098 9487 5277 9091 8818 84992 5279 5283 51227 PMC7002344__F10 Differential phosphorylation of MAPK pathways during response to cell wall damage 6094 998 54623 10519 717 10518 PMC7003246__F2 Targeting the CD47-SIRPA pathway in cancer 140885 961 920 PMC7005787__F6 UPR activation and patient outcome in cancer 83939 22926 7494 468 PMC7011147__F2 Interactions between cells in the tumour microenvironment 100187761 8205 1950 PMC7012475__F1 Monocytes in sickle cell disease 7412 8190 5281 7018 7099 PMC7014170__F5 Schematic model illustrating the signaling pathway by which ANG reduces the inflammatory responses involving Myd88 and the nuclear translocation of NFKB in LPS induced EIU 7099 4615 3565 3553 PMC7015009__F1 Hic-5-mediated signaling pathways for tumor progression 387 6714 6935 4318 PMC7015241__F10 Working model describing how MYPN and PALLD may promote SRF signalling 84665 23022 6722 PMC7015255__F6 Changes provoked by aerobic exercise training on microRNA‐1 downstream‐associated pathways in patients with chronic heart failure with reduced ejection fraction (HFrEF) 5728 9759 2475 4208 PMC7016461__F5 KEGG enrichment analysis of the hub genes 2184 351 7054 6667 PMC7017070__F1 MiRNA processing pathway 54487 29102 57510 PMC7017348__F5 Multi-component feedback loops and multi-component signaling networks involving SNAIL and non-coding RNAs 3480 22834 1499 8650 6925 6935 2335 PMC7018995__F3 Correlation of molecular mechanisms in CTCL and NSCLC and corresponding simulation results 472 407040 648 3065 993 1869 596 PMC7021762__F7 Components of GFI on KEGG gene networks 5295 5290 4616 4791 207 1956 8794 2033 7157 4893 2252 2475 3845 5728 673 1942 PMC7023692__F3 Representative diagram of circRNA mediated ceRNA network and oncogene signaling pathways 146057 7307 92799 10114 693223 7477 8324 664613 4343 6928 27086 93986 6774 23405 1499 84107 83737 494334 PMC7024330__F1 AR mediated gene transcription in different subtypes of breast cancer 367 1499 7018 3169 PMC7024330__F2 AR signaling pathway and targeted therapeutic strategies against AR 8644 3283 1586 367 6714 7018 PMC7032688__F5 Wolbachia limits pathogen infections through induction of host innate immune responses 8772 7186 23118 PMC7032926__F9 Proposed model of TLR5-TLR4 interaction during environmental lung injury 7099 7100 4615 PMC7033213__F3 Top causal network explaining observed gene expression differences 836 841 1956 2597 4088 7295 3091 142 4792 PMC7035921__F3 miRNA regulation of miR-155 upon mycobacterial infection and dual role of miR-155 in the survival of mycobacteria 406947 8651 7097 6009 64422 11337 571 4513 2309 7099 4615 PMC7035994__F2 Polarity proteins in oncogenesis 3993 9231 23513 PMC7037253__F2 Anti-inflammatory response initiated downstream of the IL-10R 29949 11009 5008 3976 3082 3587 7297 6774 6772 2932 9021 54541 602 2117 4783 22904 7538 3162 PMC7037830__F3 Binding mechanism of LPS for TLR4 activation 3929 929 7099 PMC7038207__F2 Connexin hemichannels in mechanotransduction of osteocytes 6010 1499 50964 PMC7041253__F2 Lipoprotein metabolism dysregulation in lysosomal acid lipase deficiency a) The liver secretes VLDL, which is lipolyzed in the periphery by LPL and HL to generate LDL 4023 3949 10577 4864 19 3931 PMC7042182__F8 Sketch map of the signaling axis with the most significant co-expression pattern including YY1 (Yin and Yang 1 Transcription Factor), Hepatitis A Virus Cellular Receptor 2 (HAVCR2) and mTOR signaling pathway 929 3965 84868 2475 7528 PMC7042390__F9 Wnt signaling pathway 7475 54361 7476 7471 7477 1499 4040 4041 387 2932 324 51701 PMC7044202__F9 MAPK regulated induction of cytokines in IL-33 stimulated ILC2s 90865 6761 5728 4615 2475 PMC7048131__F3 Advances of the STAT3 signaling pathways involving breast cancer proliferation and apoptosis 51741 1950 6362 1956 56950 6774 9830 8110 7942 581 PMC7048131__F4 Advances of the STAT3 signaling pathways involving breast cancer metastasis 51741 5008 8462 4232 83478 57476 6774 5292 7942 4088 7408 58480 4313 4318 PMC7049344__F7 Proposed signaling pathway downstream of CD36 through which oxidized low-density lipoproteins (oxLDL) activate phosphodiesterase 3A (PDE3A) to suppress cyclic adenosine monophosphate (cAMP) signaling 948 6850 5139 PMC7051141__F1 New control of the senescence barrier in breast cancer 10298 5971 1051 PMC7059166__F4 Cross talk dialogue between inflammatory and WBC‐signalling pathways in MPTP‐induced SVZ plasticity is lost with age 7471 2932 3162 1499 PMC7061838__F5 Relationships between GRHL2 and TGFB/MAPK signal pathways 4087 4088 4089 79977 7018 6935 PMC7062180__F1 A, the mammalian polyamine metabolic pathway 196743 84890 6723 6611 54498 PMC7064735__F3 Molecular mechanisms underlying PM2.5-induced defective airway epithelial host defense functions 435 3383 1956 PMC7064791__F1 CXCR3 receptor subtypes and related ligands that eventually result in CXCR3-B anti-tumor mechanisms, and responses in favor of tumor progression in the CXCR3-A signaling pathway following ligation of these ligands 4283 3627 6714 PMC7064973__F2 Theorised DIS3L2 and let‐7 pathway mediating gastrointestinal nematode (GIN) resistance 23318 79670 79727 129563 3586 PMC7066582__F3 Retinoid signaling pathways leading to lung cancer stem cell (CSC) differentiation and cell cycle arrest 64220 5914 2627 595 4585 1956 2535 5915 PMC7068213__F1 Graphical representation of the purine salvage pathway 2766 8833 4860 9615 84890 100 PMC7068268__F3 Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer 4827 23152 129521 PMC7071019__F2 Cellular response: APCs and T-lymphocytes 324 7054 920 PMC7071158__F3 Leptin-induced pathways 3953 3717 2308 2475 6774 9021 181 5443 4852 PMC7072176__F3 Viral miRNAs affect the pathways involved in the carcinogenesis of host cells 861 652968 836 5728 PMC7072244__F2 ALK-EGFR-AKT pathway promote STING-dependent innate immune response in macrophage during bacterial sepsis 1956 115004 29110 3661 PMC7073055__F1 Pathogenetic mechanisms in extranodal NK/T-cell lymphoma (ENKTL) 3558 3586 3578 8178 27040 3459 9046 3718 3932 3702 7535 596 PMC7074087__F7 PC inhibitor attenuated glycolytic shift and metabolic reprogramming in pulmonary hypertension 2932 2539 3939 5091 5053 PMC7074405__F1 Curcumin exerts various effects on the malignant activities of tumor cells 595 6774 3717 3082 PMC7074480__F1 Mechanism of action of the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome 79792 114548 3603 140609 PMC7075814__F3 Synthesis, release, and activation of TGFB signaling via the canonical pathway 4088 4092 4089 7006 100124696 PMC7075943__F1 Predicted lipid synthesis pathways of phospholipids in E 283871 5091 5266 PMC7075948__F1 Interferon (IFN) signaling enhancement by the inhibition of the Wnt pathway through miR-34 2932 29110 3661 PMC7085392__F3 Activation of Akt after joining to PIP3 by its PH domain 5163 7249 7248 4193 6009 2932 PMC7088938__F4 Fusion hallmarks: trends in cellular pathways fusions by fusion event cluster 6010 4803 3480 2066 PMC7090118__F3 Hedgehog pathway activation through the primary cilium 51684 5727 6608 PMC7092482__F1 Epigenetic modulation of noncoding RNAs regulate cancer biology 1956 27161 6657 54890 PMC7093717__F8 Schematic diagram depicting how luteolin inhibits airway allergic responses 3716 3718 3717 6778 2625 PMC7102569__F1 Apoptosis signaling in response to infection 7098 115004 637 3661 57506 581 PMC7103059__F3 Signaling pathways in osteoclast activation 942 941 940 7186 7189 6714 100187907 4318 4286 2353 PMC7105005__F2 CGAS/STING-signaling through Post-Translational Modifications (PTMs) 23650 6048 79102 79594 22954 81844 115004 10475 267 3638 59343 91445 8408 29110 57337 10868 11274 3661 8975 PMC7105304__F10 Leptin-mediated MTP regulation through long- (ObRb) and short- (ObRa) forms of leptin receptors 6774 7018 3717 PMC7108731__F1 Influence of rare variants in circulating metabolic biomarkers 5164 57546 55066 PMC7113187__F8 Proposed mechanism of BMP6 signaling pathway regulated by PSMD14-ALK2 axis in colorectal cancers 654 57154 10213 4090 4086 4089 PMC7125809__F1 IFN signal transduction cascade and defects in this pathway 3458 3454 3459 3460 8651 3717 3716 7297 10379 8554 PMC7139113__F1 Network for the genes included in mitochondrial functioning processes 23095 5071 4899 155061 PMC7139310__F1 PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases 23621 22926 468 PMC7139641__F3 Network of the most strongly dysregulated proteins of the glomerular ECM in FSGS 3043 335 2244 2266 PMC7139812__F1 Pathological implications of amyloidB (AB), reactive oxygen species (ROS), and neuroinflammation and their role in potential therapeutic approaches for cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD) 7295 23621 11093 PMC7139912__F2 Symplified representation of pro-inflammatory mediators in Wobbler (Wr) mouse spinal cord 3146 3606 3603 7099 4615 114548 PMC7141219__F3 Upstream network analysis of the proteins from endothelial cells exposed to ponatinib and Notch-1 signaling inhibition 4792 2309 5970 2100 3725 7157 PMC7156217__F9 Possible model for the CD40 signaling mechanisms 958 7189 7186 7187 29110 PMC7160326__F3 Modulators of the canonical WNT signaling pathway that are involved in the regulation of bone mass in human disease 7471 4040 4041 1855 4038 324 2932 1499 PMC7162481__F4 Genome-wide DNA methylation signatures to predict pathologic complete response from combined neoadjuvant chemotherapy with bevacizumab in breast cancer 23582 1356 56946 10481 10211 1789 238 11014 596 283431 92345 4193 6386 6598 983 7508 3708 54778 3716 4067 3169 3572 965 6928 2122 55534 3880 55544 117581 595 6497 3030 3875 1026 9839 3032 240 2358 6667 599 3558 5594 8553 147 4772 2908 2902 5885 6196 959 8477 6337 27347 PMC7169114__F2 Long noncoding RNAs (lncRNAs) regulate innate immune responses through activation of RIG‐I and via deregulation of epigenetic mechanisms 7099 7097 1283 5970 6352 PMC7169117__F4 Schematic illustration of the major HPV proteins and corresponding targets, by which HPV modulates the TGF‐B signaling pathway 4088 4087 6667 4089 PMC7172007__F1 Canonical Wnt/Beta-catenin signaling pathway and pharmacologic pathway mediators 6424 4040 4041 324 1499 2932 PMC7174681__F1 ER, mTOR, and CDK4/6 pathways and their links are shown 5163 64223 64798 5728 1977 1021 1019 3667 PMC7174681__F2 Dashed lines indicate a decreased interaction between two components or a diminished function 5163 5728 64798 1977 1021 1019 3667 PMC7174681__F3 Effects of mTOR inhibition are shown 5163 5728 64798 1977 1021 1019 3667 PMC7178465__F2 Danger-Associated Molecular Pattern (DAMP) binds to the Pattern Recognition Receptors (PRRs) expressed on the cytosol or in innate immune cell membranes 8564 114548 847 PMC7179206__F6 (−)-epicatechin anticancer activity in MDA-MB-231 and MCF-7 cells 27429 572 581 PMC7183669__F9 miR-135b-regulation of JADE-1 inhibited the growth of cancer stem cells and tumors in PC via the AKT/mTOR pathway 79960 2475 6657 79923 PMC7183688__F1 Participation of TNFAIP3 and UBE2L3 in regulation of NFKB activity under TNFA signaling 8737 10454 7128 23118 7332 PMC7184741__F6 Glyoxylic acid overcomes 1-MCP-induced blockage of fruit ripening in Pyrus communis L. var. ‘D’Anjou’ 355 2717 4548 PMC7186465__F1 Anticipated mechanism of action of IL-17B in tumorigenesis 7189 2932 7031 PMC7188750__F4 Application of microbial extracellular carbohydrate polymeric substances in food and allied industries 130589 2592 2582 PMC7190864__F5 Death Receptor Signaling pathway is illustrating inhibition of apoptosis in monocytes infected with Mtb 355 8772 1616 7186 8717 637 331 56616 54205 27429 397 4000 PMC7191956__F5 Tomatidine-targeted genes-related part of the top five shared KEGG pathways 4133 5604 2353 6196 6197 6195 66037 PMC7195637__F5 Regulation of mTOR on Th17 cell differentiation 2475 64798 9021 6774 3091 2672 6097 PMC7195637__F6 Regulation of mTOR on Treg cell differentiation 64798 4088 50943 2308 PMC7197434__F2 Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases 7494 1998 468 22926 PMC7198484__F4 Intracellular Staphylococcus aureus persisters upon antibiotic exposure 197257 7068 5624 7067 5162 1431 6390 PMC7199609__F2 Noncanonical functions of MAPK are emerging targets for BRAFV600E-mutated cancers 8139 115004 673 4558 8544 59330 PMC7199629__F2 Regulatory mechanisms and biological functions of MTHFD2 in cancer 10797 468 83595 PMC7200161__F6 Schematic model for possible signaling pathway related to the role of ALK7 in mediating BAT responses to nutrient stress 4087 4088 28999 PMC7204509__F4 EP remodels purine and arginine metabolism, glutathione homeostasis, and the Krebs cycle in BMDMs 3263 2539 4118 11113 PMC7210388__F8 GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17 9248 6868 6667 3280 9794 619501 PMC7210406__F7 Proposed pathway of kynurenine effects on BMSCs 6387 3620 8841 196 405 7852 9611 PMC7210546__F4 Possible cross-regulation of RAS and TLR4 in mediating the inflammation of DN 183 1636 7099 4615 PMC7212408__F3 Notch signaling activity and Hippo pathway in BCSCs 4485 55233 92597 9113 26524 PMC7212589__F8 Mechanistic working model of EVI5 in controlling Emi1 accumulation or TGF- B/Smad signaling pathway: MiR-486-5p regulates EVI5 expression via Emi1 or TGFB/Smad signaling in NSCLC 7813 4088 324 1000 999 4313 890 PMC7215321__F3 Necroptotic signaling pathway exemplified by tumor necrosis factor alpha (TNFA)-mediated activation of tumor necrosis factor receptor (TNFR)1 8717 1540 8772 8737 11035 197259 PMC7225923__F2 Cancer cell dormancy 655 2621 7124 7448 10631 7422 2475 PMC7226328__F4 Network analysis by Ingenuity Pathway Analysis (IPA) 7422 6387 9378 1305 9823 5467 367 2100 1616 10499 4884 80781 2893 6424 100423038 4087 4088 79923 2033 1387 118932 6428 83259 PMC7226356__F1 Perforin-granzyme, intrinsic (mitochondrial) and extrinsic apoptotic pathway 7124 581 637 PMC7226482__F2 Caspase-dependent and -independent apoptosis pathways utilized by cytotoxic T-cells (CTLs) and NK-cells and mechanisms of bone marrow microenvironment-mediated immune resistance 940 8772 581 637 4722 331 6418 6774 7124 3082 3479 9242 PMC7226782__F4 GSK-3/Beta-catenin in sensing of cytosolic DNA by the cyclic GMP–AMP synthase (cGAS)/STING pathway 115004 29110 1499 3661 PMC7240957__F8 Mechanism of cytochrome P450 (CYP450)-dependent metabolism of polyunsaturated omega-6 and omega-3 fatty acids involved in CKD progression 1571 4015 26136 79852 2053 PMC7241242__F8 Metabolic pathway showing the reactions involved in drought stress response at day 13: Red and blue arrows represent active reactions in drought and control, respectively 6950 3250 1431 11113 PMC7241336__F1 De Novo and Salvage Biosynthesis of Pyrimidine Nucleotides for Host and Viral RNA SynthesisGSK983 is a DHODH inhibitor 978 7371 51727 1723 790 7372 PMC7241659__F1 Cellular metabolism during T cells activation 940 2475 4609 3091 948 PMC7242393__F10 Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics 192111 2475 3661 PMC7243790__F3 Chloroquine (CQ) and hydroxychloroquine (HCQ) suppress DNA sensing by the cGAS-STING pathway and Toll-like receptor (TLR) signalling 54106 9447 3661 3665 3553 7124 3569 PMC7247259__F1 Biogenesis, structure, release, and uptake of exosomes 4827 967 914 PMC7248305__F1 Interferon signaling pathway altered by Ns 3716 6773 6772 7098 51284 4615 57506 51135 7189 7187 10010 3661 3665 10379 PMC7248305__F2 Many functions of Ns1 and Ns2 6773 51284 57506 6772 3665 10379 57762 920 3565 PMC7248678__F2 Routes of pDC sensing 7097 54106 51284 3661 4615 115004 170506 1660 3665 PMC7249489__F5 Signaling Pathways in Leukemic Stem Cells 7040 7042 7043 PMC7251695__F1 LncRNAs regulate chemoresistance through apoptosis 355 100124700 728228 8772 652995 1499 2475 387066 PMC7251695__F3 LncRNAs regulate chemoresistance through cancer cell stemness 100874041 400500 1499 9314 6662 79923 6657 PMC7251742__F9 Hypothetical scheme furtherly illustrates the mechanism of which polydatin improves osteogenic differentiation of hBMSCs via stimulating the expression of TAZ in the BMP2-Wnt/Beta-catenin pathway 650 22943 1499 324 860 PMC7253339__F1 NPC and associated factors 1104 5901 5905 PMC7256023__F3 TCA cycle is active in TGFBeta-induced EMT 2271 6389 6390 6391 6392 PMC7261174__F10 IKBKE mediated AR signalling 9641 26524 4609 367 PMC7261723__F8 Proposed model for the role of Isc1 and Cdc55 in the HU-induced signaling pathway 699 10276 10518 8556 5091 991 324 3619 PMC7263916__F4 Avian leukosis virus subgroup J and reticuloendotheliosis virus coinfection induced TRIM62 regulation of the actin cytoskeleton 3630 2147 7038 1793 324 6010 10152 5829 7414 2934 PMC7267062__F1 Mitochondrial apoptotic pathway in cancer induced by plant polysaccharides 637 572 581 355 PMC7269781__F3 BRCA pathway 545 472 466 571 1869 PMC7273800__F3 Gene–gene networks generated by pathway analysis from the 17-gene set 64324 51327 11177 84458 8821 7111 8600 85358 1588 6320 1577 5243 50856 4982 55576 11252 9094 1238 3375 9619 1548 6928 3170 PMC7274521__F6 Schematic description of resveratrol-mediated suppression of inflammation in IL-1Beta-induced SW1353 cells 3603 7099 4615 4322 PMC7275069__F3 FOXF2 acts as a crucial molecule in tumours and embryonic development 2138 5077 5159 2295 7189 22906 11309 5727 55504 6474 8817 6469 2248 5156 652 7474 2294 5154 PMC7277968__F7 Reverse cholesterol transport pathway and intravascular remodeling of lipoprotein particles during the postprandial phase 7038 4023 53369 19 PMC7278058__F6 Pathway modeling 7186 638 3627 5970 800 653361 5409 11185 3176 1499 324 6469 374654 6608 51684 596 PMC7278913__F3 SMAD4 loss and potential therapeutic strategies in SMAD4 signaling 4089 6955 693122 5230 PMC7280868__F1 Canonical autophagy pathway 3550 26100 55062 9140 9474 10533 55054 83734 PMC7281398__F5 Summary of Gene Ontology Analysis and Pathway analysis on genes that are associated with ex vivo VP16 response, ranked according to adjusted p-values 26586 7374 3161 54443 51053 54962 6596 5426 1058 11130 116028 113115 2189 5062 705 5111 PMC7281445__F1 Tumor Necrosis Factor (TNF)/TNF-Receptor 1 (TNFR1)-mediated signalling and cell death checkpoints 7124 8737 10010 9825 197259 8717 11035 PMC7281661__F6 LAB-mediated modulation of inflammatory responses in bovine mammary epithelial (BME) cells 7097 7099 4615 59307 54472 2921 3552 2920 PMC7284378__F5 Proposed mechanisms for protective effects of MWF on chronic alcohol-induced liver injury 3156 4018 39 PMC7286881__F10 Exploring the mechanism of Shengmai Yin for coronary heart disease based on systematic pharmacology and chemoinformatics 3932 3815 5228 1675 3952 7273 5972 7010 PMC7288916__F8 H19 in regulating dopaminergic neuron loss in PD 283120 3251 1499 5309 4760 PMC7294938__F3 Mechanotransduction and pathways regulating cytoskeleton during metastasis 63895 9780 387 2475 PMC7299730__F8 Serpinb6b regulation in uterine decidualization 650 54361 4313 4318 PMC7300300__F3 Schematic illustration of the intervened network with Gegen Qinlian Decoction (GQD) based on ingenuity pathway analysis (IPA) 9370 6517 2597 31 34 2673 32 6720 5465 5468 7069 10891 4023 51 33 PMC7301251__F3 Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology 4128 43 7428 3265 2475 8505 1956 581 7077 4313 3845 5728 4323 673 7422 324 4609 9429 4129 59067 7124 6256 2064 596 367 2247 3725 1991 3880 3359 7015 7431 5241 2628 590 18 PMC7307098__F8 Working model of the innate immune response to papillomavirus infection of the female lower genital tract 1235 4615 6364 6772 PMC7308527__F1 Tryptophan (Trp)→ kynurenine (Kyn) metabolic pathway 8942 8564 130013 23475 PMC7309610__F2 Innate immune pattern recognition of bacterial lipids on OMVs leads to inflammation and death 3929 7099 114609 929 4615 3661 114548 3553 PMC7310461__F3 Alterations in SLE signaling pathway based on calculated final parameters 8345 3012 6628 3015 8346 3018 6632 8970 8329 85236 317772 3017 8331 158983 55766 55506 8342 286436 8341 3013 8350 8370 440093 8369 3020 126961 715 3108 720 3118 3109 3119 718 3492 721 3111 3122 3112 3123 3113 716 3125 3126 3115 3127 7124 727 731 1511 2212 729 732 958 959 3458 733 1991 2214 730 942 3586 940 735 2209 941 PMC7313026__F2 RNF186, RNF182, and RNF152 are involved in the regulation of the mTORC1 pathway 1950 1956 221687 54546 220441 6009 7375 3170 6469 PMC7313395__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the JAK/STAT Pathway in Trypanosoma cruzi-infected myoblasts 8027 6774 9063 10401 8554 5771 59067 23529 6772 5292 3717 759 2670 2273 2033 2885 8544 2475 4099 3716 3718 7297 1441 1440 PMC7317222__F6 Cholesterol-oxysterol metabolic pathway 7054 10858 9023 PMC7317223__F4 Cell cycle and signalling pathway cascades in the Chinese ESCC subtypes 999 7046 7048 324 8312 4089 4609 6932 6790 64151 891 5347 10112 1019 22974 4288 995 9055 595 6502 1017 890 PMC7322951__F3 Accumulated lysosomal products on cellular and tissue homeostasis 4827 847 7076 7099 PMC7323198__F2 Schematic summary of SARS‐CoV‐2 entry into host cells, replication, effect on host cells, and postulated effects of statins 59272 6502 114548 8678 3553 7018 PMC7324377__F1 Biological pathways associated with the response to Ni(S-tcitr)2 in yeast 100187761 8039 348 4397 PMC7324671__F7 Proposed working model for IL-21-induced B cell differentiation and IgA-producing plasma cells in porcine Peyer's patches 50615 6772 6774 5079 604 PMC7325056__F10 Intestinal microecological mechanism of diarrhea caused by Folium sennae extracts 15 1644 438 4129 316 PMC7328278__F8 Downregulated miR-18b (miR-18b-5p) signaling pathway in fALS linked SOD1 mutation 79772 3091 5915 4208 596 PMC7331465__F1 IL-7R Signaling Drives Proliferation and Survival while Preventing Premature Igk Recombination Programs During B Cell Development in Mice 2475 4609 572 3575 2308 596 4170 896 5896 5897 54014 50802 PMC7334005__F6 Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space 1407 23411 10135 8864 406 3066 8841 9611 8473 211 PMC7335670__F7 IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer 8826 1499 207 PMC7337964__F9 Expression profile of genes in Hepatic fibrosis pathway for Pre_S cohort 4982 3587 2335 80781 7099 1277 1906 3479 3487 596 1307 25805 2321 3556 355 3488 7042 7046 3459 1889 7048 1278 2263 1281 3486 5054 4790 4092 1302 85301 1435 79784 7422 3791 3576 2921 PMC7339783__F9 Graphic summary of the findings of the present study 3146 7099 3553 PMC7345582__F2 Onco-suppressor microRNAs in the inhibition of STAT3 and the malignant behavior of gastric cancer cells 406910 6774 7291 3036 PMC7349363__F1 Notch signalling and strategies for pharmacological targeting of this pathway 102 6868 54567 5045 3280 23462 PMC7350910__F4 Crosstalk between the TNF-related pathway and CS response 2638 8797 7124 8772 PMC7352588__F4 E3-ubiquitin ligases and DUBs involved in Smo regulation 6608 26091 1850 PMC7352628__F7 CIGB-300-mediated effects on T-ALL cells 3575 3718 5728 3716 PMC7352656__F1 Molecular mechanisms for acquired resistance 1950 3082 2621 1956 3480 558 5728 6774 2475 PMC7352995__F2 Role of fibroblasts in mammary gland branching and BC growth 5156 2247 1956 10252 PMC7353017__F1 EGFR (epidermal growth factor receptor) and VEGFR (vascular endothelial growth factor receptor) signalization pathways 1956 4893 3265 3845 5281 673 10342 1950 5728 5163 2475 PMC7354282__F4 Renal diseases 1356 197 259 324 721 720 629 2638 3383 1431 1401 3240 325 3273 PMC7357070__F3 Toll-like receptor signaling pathway includes the highest number of the proteins identified, related to immune system pathways and appearing in both SARS-CoV-2 and HIV-1 infections 7097 5879 114609 8772 3929 929 51135 920 1513 130749 54106 114034 PMC7359022__F2 Release of HMGB1 protein and HMGB1 signaling pathways 3146 7097 7099 7852 4615 54106 PMC7359176__F3 Unphosphorylated glycogen synthase kinase-3B (GSK-3B) and canonical WNT/Beta-catenin signaling in “off” state 4040 4041 2932 1499 324 PMC7365992__F3 Extrinsic pathway involves transmembrane receptor mediated interactions 355 8772 6955 PMC7369834__F1 Genomic and non-genomic effects of glucocorticoid receptor (GR) binding to the different players of the inflammatory and metabolic pathways involved in the Duchenne muscular dystrophy (DMD) myocyte 1756 3667 2475 1616 PMC7376433__F1 Molecular pathways involved in hereditary cancer risk 5395 10111 2956 4436 4361 472 11200 4763 2475 7157 580 79728 PMC7377904__F3 Vitamin D interferes with Beta-catenin induced gene expression via different pathways in different cell types 1499 7421 4041 6423 PMC7378638__F5 Enterohepatic action of FXR and FATP5 7038 2264 9965 PMC7382829__F8 Fatty acid metabolic pathways in macrophages infected with Nc-Spain1H versus non-infected cells 2194 355 2241 2091 2233 2242 5471 PMC7392626__F1 cGAS-STING pathway in oncogenesis and cancer therapeutics 5167 115004 29110 7187 10010 7186 3661 PMC7395689__F1 Figure describes the process by which AVB3 mediates prostate cancer cell metastasis 6678 1490 6347 58191 6714 389432 860 2475 PMC7396444__F4 Expression of DEGs involved in the apoptosis and autophagy signaling pathways 8772 1616 790 7808 7939 8739 3630 PMC7400296__F1 Fibrosis regulation by RBM7 via NEAT1 ncRNA decay in the lung 283131 10179 6387 PMC7400809__F4 Action of TET inhibitors 4211 80312 6774 6667 PMC7404121__F2 Synergistic regulation mechanisms of leaf angle by phytohormones in rice 6046 23774 1431 PMC7405025__F2 Pathogenesis and management of myocardial injury in coronavirus disease 2019 59272 7124 6347 7113 6761 PMC7405480__F3 The PI3K/AKT pathway by binding and ubiquitylation of tumor-regulating proteins in gastric cancer 11059 57154 23239 5728 153090 PMC7407016__F1 Regulatory circuits driven by liganded ER-alpha for DNA stabilization (A), cell proliferation (B), and fuel supply (C) 3480 1956 672 2475 3667 PMC7407683__F5 FSH and ovarian cancer 7222 5728 3091 595 6657 79923 PMC7408912__F4 Scheme presenting the major proteins of the DNA damage response (DDR) signaling pathway and the miRNAs that interact with them 3014 693122 472 693215 PMC7409684__F1 Pathological roles of ion channels and transporters in triple-negative breast cancer cells 360 1080 358 3480 90550 PMC7412063__F4 Interactions between network molecules and DNA damage checkpoint pathways 472 1356 25 30814 5347 8993 3002 176 220323 PMC7413060__F1 Innate immunity in the initial phase of infection 100049587 114548 51284 3553 PMC7415163__F1 Complement activation pathways and narsoplimab mechanism of action 715 716 717 718 727 PMC7417304__F4 Emerging roles of Hippo-YAP signaling in the modulation of innate anti-tumor immunity 9113 1435 3565 3596 4615 PMC7422622__F1 Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms 4312 3490 7035 7057 3082 PMC7422669__F1 Clearance processes for apoptotic cell by phagocytes rely on “find me” and “eat me” signals that signal their internalization (A) “Find me” signal: apoptotic cells release signals that attract phagocytes to the site of programmed cell death 6376 2833 2621 10461 7040 PMC7425174__F2 PD-1-mediated immune regulation 324 941 942 940 PMC7427429__F3 Pathogen-derived molecules enabling VP22 to evade the DNA-sensing pathway in cells 9447 115004 3553 3661 29110 PMC7428229__F7 DEGs mapped to the cysteine and methionine metabolism pathway in shoots 6611 84245 51074 55256 PMC7432147__F4 Direct regulatory function of linc-ROR in various cancers 2475 1849 4087 PMC7432414__F6 Putative signaling pathway involved in HRPC–CAF transition mediated by PDGF-BB increase 3622 6373 6362 PMC7432706__F1 Biosynthetic pathway of ganglio-series gangliosides 7357 9334 8869 2583 8705 51046 PMC7432706__F2 Leptin receptor signaling pathway, and alterations in signaling that characterize various ganglioside-deficient KO mouse models 3717 8660 25970 9021 6774 5443 181 PMC7435507__F1 Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection 790 1723 7372 718 790 1723 7372 PMC7442787__F7 Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused 151987 51684 5727 4151 PMC7444709__F3 Physiological and pathophysiological functions mediated by TRPC4 in response to receptor-operated activation of Gq/11 and/or Gi/o proteins. A & B 7223 23440 4666 83737 7220 PMC7445288__F6 Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate 84870 5796 324 196528 54894 2932 6934 55294 2064 2065 4763 26298 1999 673 5925 6416 595 472 5728 11168 PMC7449914__F7 Proposed mechanism: HDAC3 regulates the transcription of cGAS by deacetylating p65 at K122, which plays a role in ischemic/reperfusion-induced neuroinflammation and brain injury 8841 3661 29110 115004 6285 PMC7452853__F11 Proposed mechanisms associated with 10% XCDM-induced hTM cell stiffening and Wnt pathway activation-mediated rescue of cells from stiffening 4040 4041 1499 387 8313 960 857 284119 1896 59 PMC7453253__F1 Imbalance of T cells in asthma pathogenesis 6775 90865 355 64806 50943 6778 85480 604 2625 PMC7456423__F6 Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway 6714 6497 4312 PMC7459646__F7 Effect of parental Se nutrition on the methionine cycle and transsulfuration pathway in the progeny of rainbow trout 27232 1786 4548 635 875 PMC7460810__F1 Biogenesis pathway of YRNAs and YsRNAs 6738 5901 6041 PMC7461309__F1 Pollen-induced activation of the innate immune system and Th2 polarization 2625 6778 6361 643 6367 10563 3662 7099 6761 85480 90865 64806 7124 PMC7463266__F9 Illustration of this study’s results and a working model 4090 4086 860 84913 PMC7463953__F2 Putative target gene interaction network graph generated using Ingenuity Pathway Analysis of miR-34 and miR-181 family miRNAs nodes within a simulated cell 5368 100 4137 PMC7465315__F1 Keratinization at a glance 7051 7053 7808 PMC7467536__F1 PRC2 core and accessory proteins and downstream effects 100170841 4199 4200 10873 121536 22823 PMC7468434__F1 Mitochondrial dysfunction in microglia 54209 948 90550 114548 PMC7468437__F6 Gene network of “Rap1 signaling pathway” term enriched in both IgG4-RD tissue proteomic data and LSG transcriptomic dataset 4254 9732 3082 2252 10000 1956 80310 2247 57568 5156 2776 7057 23094 3674 4804 2533 23236 2775 5330 6494 2321 5579 5880 3683 5604 56288 5216 999 PMC7472700__F1 CGAS–STING pathway 3455 115004 7189 10379 3550 3661 5971 PMC7476100__F7 Mechanistic model to show how MEQ inhibits triple-negative breast cancer (TNBC) angiogenesis by regulating the MTA2/SerRS/VEGFA axis 9219 7422 4149 22933 PMC7476662__F4 Predicted genes in the MAPK signaling pathway targeted by downregulated serum miRNAs (miRNAs) in BD, sarcoidosis, and VKH 100126297 100126320 102465864 785 4208 1386 57551 2005 2258 23118 3845 5536 5062 7046 355 673 2259 6237 100500817 100847080 PMC7478169__F1 Normal downstream pathway of TSC1 and TSC2, and its gene products 7248 7249 6009 64223 PMC7478175__F7 The complosome in T cell homeostasis 4179 4851 3575 1514 940 PMC7481463__F6 Biomarker metabolites network based on intelligent pathway analysis use IPA analysis 3497 3569 85451 5027 PMC7485092__F2 Innate and adaptive immune responses in SARS-CoV-2 Infection 2921 6347 3569 50616 3586 3565 3458 920 PMC7485335__F2 ICOS signaling pathway in Tregs 324 941 942 29851 940 2932 50943 2833 PMC7488754__F1 Scheme of processes that maintain a certain receptor density on the postsynaptic membrane at the activated synapse 85358 7249 7248 6009 PMC7490471__F1 ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway 1950 2885 5594 6935 55841 1956 PMC7490524__F1 Alternative splicing rewires Hippo signaling during chronic liver injury and HCC 4771 80004 6657 55796 PMC7490765__F5 Molecular basis of drug resistance in cancer 6714 8412 472 545 2475 3479 1956 PMC7492727__F4 Proposed pathological mechanisms of MuSK autoantibodies at the NMJ 43 4593 1636 285489 49 PMC7493965__F10 Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-tomesenchymal transition 10758 3553 8434 7078 4313 PMC7497066__F1 Frequent mutations in positive (green) and negative (red) regulators of the NF‐KB pathway in MM 4055 973 974 613 7188 7189 7187 7186 8915 10892 1540 5971 PMC7499473__F1 Targeting CXCR4 7852 6387 2475 9242 PMC7501145__F1 Nutrient Transporters by Metabolic and Environmental Stresses 6493 6492 4046 324 PMC7503990__F1 Structure and biosynthesis of fucosylated glycans 2525 2523 2529 2526 2524 2528 2527 2762 2530 23509 23275 PMC7504480__F1 eATP/P2X7R Axis: An Orchestrated Pathway Triggering Inflammasome Activation in Muscle Diseases 7099 3146 4615 3654 51135 3553 7189 140609 114548 PMC7504721__F1 Complement is activated by three canonical pathways known as the classical pathway (CP), lectin pathway (LP), or alternative pathway (AP) 718 6697 716 717 715 1356 727 730 729 735 PMC7506056__F9 Aucubin attenuates liver ischemia-reperfusion injury by inhibiting the HMGB1/TLR-4/NFKB signaling pathway, oxidative stress, and apoptosis 4615 3659 3603 PMC7506080__F1 Upregulation of AMH production in testicular Sertoli cells 268 6662 7536 6957 2626 6736 PMC7507458__F1 Molecular schematic of canonical Hippo signalling cascade in cancers 4485 60485 9113 26524 PMC7508753__F2 Contribution of the embryo, fetus, and trophoblasts to the programming of immune adaptations during pregnancy 3135 3133 2920 2921 6372 6387 PMC7512067__F6 Summary diagram outlines the working mechanisms of oridonin in FaDu cells 7473 1499 1000 999 PMC7519545__F1 ABCA1 cell signaling pathways 335 7099 19 10461 4615 22937 PMC7521558__F7 Schematic model summarizing the effects and signaling pathway of SRA in RCC 595 1019 1021 1000 960 6657 100133941 9429 999 PMC7522758__F1 Circadian Dysregulation of the TGFB/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells 4089 4088 4092 1407 55364 7018 PMC7526609__F2 IL-2 mediated JAK-STAT signaling pathway in COVID-19 associated male infertility.This figure shows IL-4 JAK-STAT Pathway and their effect on male infertility, during the event of infection by SARS-CoV-2 3716 6774 6778 948 4128 PMC7526619__F1 Omega-3 and omega-6 long-chain fatty acids synthesis pathways compete for the same enzymatic machinery in the cell 60481 4513 4512 717 54898 64834 83401 6785 PMC7533414__F5 GSDMENT switches apoptosis to secondary necrosis/pyroptosis 836 1687 3146 PMC7533414__F6 Gasdermins augment the mitochondrial apoptotic pathway 834 836 1687 79792 PMC7540110__F1 Cell cycle regulation through cyclin E 1021 1019 1017 6657 PMC7551072__F1 Regulation of metabolism by B vitamins 1719 4144 4397 635 4524 875 PMC7553775__F7 Coordinated repression of A3B transcription by both E2F4/DREAM and E2F6/PRC1.6 complexes 83746 91750 55957 6015 84108 286826 10138 23429 5928 23269 7027 7029 1874 132660 1876 5934 5933 PMC7555474__F5 Rap1 promotes tumor progression via disruption of E-cadherin-mediated cell adhesion 999 1000 5909 PMC7555758__F1 Interplay between neurons and glia in various conditions 3553 387 3479 90865 627 PMC7557985__F11 Differential mechanisms of CK2.3 in osteoblastogenesis and osteoclastogenesis 860 100187907 81501 PMC7558103__F1 The nicotinamide adenine dinucleotide (NAD) metabolism 93100 64802 349565 23057 10135 PMC7563533__F2 Key databases as primary resources for drug repositioning 5741 1283 1152 PMC7563617__F5 Metformin-induced CSC suppression through AMPK activation and inhibition of protein prenylation by suppression of the mevalonate pathway 3156 2475 3652 2224 6713 6010 9453 PMC7563658__F1 Canonical and non-canonical nuclear factor K (kappa)-light-chain-enhancer of activated B cells (NFKB) signalling pathways 958 5971 5970 PMC7564329__F6 Proposed molecular mechanism underlying increased neural excitabilities and susceptibility to ischemic injury caused by IL-4 deficiency 3565 2559 6323 3566 PMC7564482__F1 Folate-homocysteine metabolism pathway and possible causes of folate deficiency 1719 4548 4552 27232 100188776 PMC7564842__F2 Signaling crosstalk between the KRAS and NFKB pathways 3553 4615 3845 51135 5899 29110 PMC7564852__F3 Schematic depicting the molecular mechanism of co-activators involved in TCF/LEF-dependent Beta-catenin transcriptional activities and their functional consequences 3065 2146 4609 8313 7088 2305 22943 595 1499 8549 6304 6934 57761 6932 4313 PMC7565951__F2 Roles of TRIM proteins in pattern recognition receptors (PRRs)-mediated immune signaling pathway 9958 7706 57506 54765 7187 29110 3661 3665 3663 PMC7565963__F1 Hedgehog signaling pathway 374654 6608 51684 2735 5727 2736 91653 PMC7567953__F3 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics 9294 7474 2932 4041 1499 PMC7569310__SF1 Transient Receptor Potential Ankyrin-1 and Vanilloid-3 Differentially Regulate Endoplasmic Reticulum Stress and Cytotoxicity in Human Lung Epithelial Cells After Pneumotoxic Wood Smoke Particle Exposure 7494 83939 468 1649 467 PMC7573563__F1 Innate immune response during ADE and non-ADE dengue infection 10010 7098 51284 23586 9021 PMC7573576__F3 Synthetic lethal pathway: dual pathways 8068 672 142 PMC7575966__F1 Enzymes and intermediate products of the heme synthesis pathway 7389 210 2235 7390 PMC7576355__F2 CDK4/6 pathway and FOXO3-FOXM1 axis: Cyclin D-CDK4/6 complex phosphorylates FOXM1 transcription factor which is involved in expression of G1/S phase genes 367 1021 1019 2309 2305 7157 PMC7576987__F5 Working model of 2,3-DCPE in colon cancer cells 472 545 993 PMC7577320__F1 Malic Enzyme 1 (ME1) in the Biology of Cancer: It’s not Just Intermediary Metabolism 3939 47 2194 4200 10873 PMC7582405__F5 Most significant IPA networks involving the proteins that were differentially regulated between the CF and control states 462 337 3426 PMC7582747__F3 Proposed regulation of PlGF and TGFB in early diabetic retinopathy 5281 7048 4087 4088 6935 10935 1003 1907 5175 100506658 284 PMC7583347__F1 S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease 9817 2638 1728 2730 59341 8829 PMC7583981__F5 Pyroptosis contributes to interstitial fibrosis 4087 4088 4089 114548 3606 PMC7588972__F1 Pivotal role of Mediator complex in the ABA signaling pathway 81857 1024 54797 PMC7588972__F2 Simplified network of TFs and Mediator complex in regulating the abiotic stress responses 9282 10025 1024 81857 PMC7589980__F1 Susceptibility genes present in the double-strand DNA break repair pathway for ovarian and breast cancer and its different correspondent risks levels in each disease 472 545 11200 580 1111 672 83990 79728 5889 5892 7516 675 4683 10111 4361 PMC7595202__F6 Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma 3667 5163 1977 3091 PMC7595734__F3 Lipid scavenging by extracellular arthropod-borne pathogens 5091 4023 355 PMC7597513__F2 This is a simplified version of the canonical nuclear factor kappa B cell (NFKB) pathway that is negatively regulated by A20 binding inhibitor of NFKB (ABIN1) function 4615 3654 51135 7189 PMC7599158__F3 Proposed molecular functions for lncRNAs PICSAR and PRECSIT in cSCC 1956 283487 378825 4319 1848 4312 PMC7600363__F2 Biosynthesis and major signalling pathways activated by FLT3 wildtype (WT) (a) and FLT3 with internal tandem duplication (ITD) mutation (b) 2322 50507 5795 PMC7601648__F2 Non-canonical NFKB signalling pathway and the role of ubiquitination 958 56957 7187 7186 80829 5971 PMC7604490__F2 Genetic pathways implicated in vascular anomalies 2475 2022 3815 5163 2776 2767 9630 5728 4763 673 PMC7604619__F3 Kinase pathways deregulated in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) 2056 2322 3560 3716 3717 4893 3845 5447 4067 2260 25 27 5156 5159 4916 596 1399 2475 10019 7750 PMC7605288__F1 Caudal-related homeobox transcription factor 2 plays different roles in embryo, intestinal epithelium and colorectal cancers 324 1499 8313 1045 1017 79923 2932 2475 472 PMC7605660__F7 The underlying mechanisms of zeaxanthin’s effects on signaling pathways and the induction of apoptosis in human gastric cancer cells 6098 6774 572 891 983 1017 142 PMC7606114__F4 Lysosome and pyroptosis 114548 79792 3603 PMC7607189__F1 miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease 6424 8772 405 83540 6294 23429 10538 2184 2152 27040 53335 27245 PMC7613405__F4 Notch signaling pathway and the processes of lateral inhibition and induction 4855 4853 4851 4854 2271 PMC7641573__F5 Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway 1499 1000 999 PMC7642512__F2 CD40 induces activation of autophagy signaling pathway 958 85451 2475 8408 64422 10533 9140 9474 55054 PMC7644826__F2 Canonical WNT signaling 4040 4041 2932 324 847 PMC7645048__F7 LINC02381 effect on Wnt signaling pathway 1499 400043 324 PMC7647985__F4 ERK5 regulates the FAK signaling 7448 2247 3690 3688 3693 389 4792 2885 1398 1795 7422 10163 5879 5328 6010 7077 PMC7648632__F1 PD-L1 degradation pathway and immunotherapy for cancer 8405 1021 1019 999 1499 6925 2932 1956 472 54918 146223 PMC7649967__F2 Biglycan in the Skeleton 50964 4036 4041 64750 57154 4086 860 22943 4040 650 633 4772 126014 100187907 799 PMC7655160__F8 Graphical model displaying the mechanisms of ARHGEF11 in regulating cell cycle and EMT via activating Beta-catenin 999 1499 6935 PMC7660801__F5 Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement 4153 1378 10747 720 721 718 735 729 966 1431 PMC7662962__F2 Platelet activation by CXCR chemokine receptors 58191 4282 6373 10663 7852 PMC7664432__F1 Complex regulation of E-cadherin expression 6774 999 6608 2736 6935 PMC7665242__F4 Cooperative participation of epigenomic and genomic alterations in the clinicopathological diversity of gastric adenocarcinomas: significance of cell adhesion and epithelial–mesenchymal transition-related signaling pathways 3082 1956 4117 PMC7667972__F9 Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch 80821 1690 747 9290 PMC7668088__F9 Conceptual model of OR2W3-evoked ASM relaxation and bronchodilation 343171 84876 6786 1080 3643 PMC7670535__F1 Role of AKAP13 in cardiac function 11214 6722 4208 PMC7671541__F6 ED-71 inhibiting NLRP3 inflammasome-dependent pyroptosis in HGFs 7099 114548 834 79792 3603 PMC7672029__F4 Flowering and sex determination metabolic pathways: identification of candidate genes underneath the QTLs 1407 100306940 2160 7018 100187761 178 PMC7675715__F1 Sensitivity of cystic fibrosis transmembrane regulator (CFTR) carriers to COVID‐19 inflammatory response 1080 59272 3553 PMC7677403__F2 Toll-like receptors (TLRs) mediated signal transduction pathway 7098 51311 51284 54106 4615 3661 3665 PMC7677509__F6 Cyclin G2 inhibiting the growth and metastasis of OSCC by binding to IGFBP3 and regulating the FAK-SRC-STAT signal pathway 3486 901 6714 6774 4318 PMC7679954__F1 Signaling pathway of NOD1/2 and most TLRs are interconnected through complex pathways 10392 64127 3725 PMC7680500__F3 Quantitative proteomics revealed energy metabolism pathway alterations in human epithelial ovarian carcinoma and their regulation by the antiparasite drug ivermectin: data interpretation in the context of 3P medicine 48 5162 55753 1431 3419 2271 4191 8801 3420 3418 5106 PMC7682108__F1 Intracellular cholesterol homeostasis 3156 3949 9619 19 64241 64240 PMC7683158__F2 SUMOylation in the hypoxia pathway 51588 4286 8535 26168 10013 PMC7686287__F6 Schematic summary of high glucose activated NFKB pathway 3553 3717 3716 6774 4313 4316 595 PMC7690341__F1 Pyrimidine nucleotide synthesis and chemical structure of PTC299 790 139596 7372 83549 7371 978 PMC7691682__F8 Some transcripts encoding enzymes involved in the glycosylphosphatidylinositol (GPI)-anchor protein biosynthetic pathway are down-regulated in the CF specific medium (CFSM) culture condition (G condition) 5279 5283 8818 9487 23761 284098 93183 5281 8733 10026 80055 2821 PMC7692253__F2 Identified B lymphocyte‐induced maturation protein‐1 (Blimp‐1) targets in mononuclear phagocytes (MNPs) 3394 3662 9935 639 1471 91662 3439 3627 6347 6614 942 6355 1520 PMC7692350__F1 Molecular signaling pathway underlying NETs formation induced by different stimulus 7099 6714 4353 2821 PMC7692643__F2 Hippo pathway 4485 9113 26524 PMC7692643__F6 Proposed mechanisms of YAP/TAZ activation in CMS4 CRC 1499 324 4485 2932 9113 26524 PMC7693142__F3 Methionine and folate cycle pathways involving PLP-, FAD- and B12-dependent enzymes 1491 875 4524 4397 PMC7694131__F1 Canonical and non-canonical Wnt signaling pathways 324 2932 1499 387 860 4040 4041 4920 PMC7696043__F1 Nuclear factor-kappa light chain enhancer of activated B cells (NFKB) pathways 4049 4050 5970 5971 PMC7697663__F3 Early antigen-driven transcriptional pathway in effector CDT8 T cells and in exhausted CD8 T cells 940 3662 864 10538 7124 9760 PMC7698938__F5 Mechanisms of therapeutic effects of Cinacalcet on CKD-MBD 50964 5741 1401 PMC7699002__F1 Sulfur Metabolism Under Stress 4548 1491 2936 2242 PMC7709131__F1 Complement system schematic summary 717 721 5648 7448 966 2271 4179 1604 PMC7709131__F3 Complement functions in the context of cancer 5806 2271 1380 51741 355 PMC7709628__F1 Interplay between nutrient-sensing pathways potentially affecting health span 3630 3479 26291 2475 PMC7710911__F2 ACAs and CENP-B: CENP-B bound to CCR3 1059 1232 1839 1956 6714 PMC7712612__F3 MIR22HG is involved in signaling pathways that affect cancer progression 4087 84981 4089 6615 1499 595 999 1000 6774 23462 4853 PMC7713309__F5 Ingenuity pathway analyses of the dendritic cell maturation pathway (A) and TREM-1 signaling pathway (B) at 72 h post-infection, and expression level of related genes (C) 6348 958 942 1437 2207 2209 2213 2549 3109 3117 3119 3122 3383 3569 3606 3592 3552 51561 26525 8660 4049 4055 6300 4792 5333 58484 114548 91662 10392 64127 7097 7099 10333 51284 7132 54210 54209 7305 221527 PMC7713543__F2 SARS-CoV-2 Replication and Interaction with Host Cells(A) Simplified schematic of the viral replication cycle 7113 59272 7098 51284 57506 PMC7718329__F7 TET1 and 5hmC in an obesity-linked pathway driving cancer stem cells in triple-negative breast cancer 847 80312 23435 6427 79923 PMC7720507__F6 Internalization pathway of PLGA-PEI PCS NPs in MSCs 55364 4827 594857 8411 928 967 975 PMC7723514__F6 Pimozide in prolactinoma bromocriptine resistance 5617 5618 3717 595 PMC7727543__F1 Key mutations in gene categories represented in MDS/MPN overlap syndromes 3717 867 5781 4763 8314 23451 171023 54790 861 6427 PMC7728626__F3 C-Jun N‑terminal kinase (JNK) activation in obesity-induced diet: 3569 7124 9021 5465 9611 26291 PMC7729316__F1 Therapeutic approaches targeting tumor angiogenesis 2022 54567 3397 55273 PMC7735419__F8 Proposed molecular mechanisms of GPX8 in gastric cancer cells 2296 493869 2932 324 1499 PMC7736044__F1 Interplay between cysteine protease activation and mitochondrial deteriorating processes in MS myelin degeneration 3920 4099 4397 PMC7738893__F3 Molecular mechanisms for impaired antibody therapeutic activity in cancer 3586 924 729 PMC7738984__F8 Identification of the target genes and construction of its dynamic regulatory network 6869 6288 3240 718 3932 51764 3356 2793 114 1950 1956 PMC7745059__F1 Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway 115004 29110 5167 3661 115004 5167 29110 3661 PMC7746852__F3 Insights into the counteraction of host defense by viral protease and Vpu 29110 57506 3661 1499 5194 8799 5191 5828 PMC7746952__F1 PAR1 functions in thrombotic and inflammatory processes in the vascular endothelium 4312 7450 324 7018 PMC7750537__F7 Crosstalk between coagulation and autophagy promotes cancer-associated thrombosis and metastasis 7039 8205 100187907 PMC7754343__F1 Simplified schematic of the kynurenine pathway 169355 3620 3398 6999 8942 8564 10135 23475 130013 PMC7757024__F1 SIRT1 modulates glucose metabolism through regulating cell secretion 2167 23411 23564 7351 PMC7757049__F3 miR-340 is associated with various genes modulating cancer cell proliferation 3716 6502 1019 1499 8549 2274 652 901 PMC7758837__F1 Emerging therapies in Parkinson disease — repurposed drugs and new approaches 65018 5071 6622 120892 2668 3902 PMC7762867__F1 Inflammatory signaling pathway in macrophages 7099 3654 4615 4790 5970 51135 4118 3656 7189 7124 PMC7764608__F5 NF-ĸB signaling pathway 613 3716 3717 4615 6850 6778 6774 3654 51135 84433 5292 10892 11040 7189 960 596 4609 6003 973 974 PMC7767317__F3 Modulation of the Nrf2-vitagene pathway by H2S 9978 8452 9817 23411 114548 4094 PMC7769821__F5 KEGG pathway schematic diagram of cytokine-cytokine receptor interaction 3976 5617 6503 3952 PMC7770494__F33 International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 998 1020 1641 7249 7248 4763 PMC7773902__F2 Summary of the different therapeutics applied in aGVHD treatment 324 9242 1493 1043 PMC7775612__F2 Cell signaling pathways activated in acute inflammation induced by carbon nanotubes (CNTs) 3553 3554 6850 114548 PMC7778498__F1 Endosteal, reticular, and vascular niches in the context of bone marrow 3458 3553 5741 4151 7908 8213 6387 27123 22943 650 7480 PMC7779329__F3 SARS-CoV-2 and relevant biological processes that involve ACE, PGR, FXIIIB, and tPA 59272 7113 1636 5241 5340 PMC7779461__F5 Chemokine Signaling Pathway Based on DAVID Analysis of KEGG Pathway Database 2885 572 1794 387 1610 PMC7780023__F4 TET2: A cornerstone in normal and malignant hematopoiesis 54790 6774 7189 PMC7780992__F1 Conceptual overview of potential mechanistic pathway of Aspergillus fumigatus recognition through pattern recognition receptors in dendritic cells to upregulate IL-10 production and to downregulate allergic hypersensitivity reactions 7097 4615 10892 PMC7785737__F3 Wnt signaling pathways 4040 983 324 2932 1499 PMC7790916__F1 Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway 5781 5140 5163 5728 9882 2932 PMC7791172__F1 NOD2 regulates AMP A‐defensins expression and AMPs sorting in PCs 2254 2261 120892 5862 64127 5971 5966 PMC7791185__F9 NLRP3 Inflammasome Activation and Pyroptosis in Lactate‐stimulated Human NP Cells 9311 114548 79792 PMC7792434__F1 IL-39 and signaling pathway 10148 149233 6772 6774 PMC7793734__F7 Hypothesized mechanism by which endothelial cells promote docetaxel resistance of prostate cancer cells 2247 5091 8178 2078 2475 PMC7793839__F1 Toll-like receptor 4 (TLR4) signaling pathway 4615 7099 51135 7187 3654 7189 29110 3661 3553 PMC7794175__F1 Genomic alterations in the cyclin pathway in patients with cancer 1029 1030 1026 1027 1031 595 894 896 1021 1019 6598 4088 2099 5925 367 PMC7794676__F5 Pyroptosis on the tumor microenvironment 841 56169 55876 3001 3002 836 1687 PMC7794713__F2 Net cholesterol flow through the body 3156 39 19 1244 3949 PMC7795823__F6 Proposed mechanisms for the action of ACF on melanoma cells under normoxic conditions 387569 5170 1998 468 5163 PMC7797046__F5 Schematic showing the biosynthetic pathway of OHyW in wild type cancer cells (blue area) and taxol resistant strains (red area) 127253 129450 55253 PMC7801429__F4 An ER signaling pathway network identified by IMPALA using Symmans data 2099 5295 6197 3320 1432 6714 1956 6464 2549 1398 1457 6622 5584 2885 7454 3937 3925 4067 3635 5781 3932 1147 10657 5062 4790 3716 2908 836 6774 3725 2353 PMC7801517__F7 ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway 2669 9294 596 581 PMC7801705__F6 NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease 64127 8411 64284 PMC7801920__F2 Related molecules, genes, signaling pathways and biological function in HCC of miR-200 family 6935 728655 9839 9043 5928 3170 79805 6010 648 1788 5090 100506844 5728 PMC7802409__F3 Microglia damage to neurons after encephalitis leads to neurological complications in survivors 3458 3603 57162 64805 53829 PMC7804955__F7 circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity 338376 4708 3665 1283 57506 PMC7806208__F5 Pathway schematics of pharmaceutical and ligand interventions of three signaling pathways known to be active in mammalian A549 cells 7046 7048 4088 4087 4089 4193 PMC7811275__F3 Regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) 57506 3661 3454 10379 3455 3659 114548 834 79792 839 81030 11035 8737 841 840 836 8772 197259 PMC7813639__F2 Prospects for pharmacological targeting of pseudokinases 5266 3717 2057 2690 54757 56975 673 2444 2056 64326 10221 28951 PMC7814595__F3 Different T cell subsets infiltrate the injured brain 4283 374 920 3603 5771 PMC7814617__F7 Schematic model for the mechanism of action of anemoside B4 in the treatment of colitis 6280 7099 581 PMC7814730__F4 DILI-related processes inferred from predicted targets and pathway annotations 5916 2101 27330 2167 993 5319 9133 6916 85417 4835 10499 1588 1544 1559 5564 8644 1459 7157 1646 231 8445 9536 PMC7814972__F1 Deoxynivalenol (DON)biosynthetic pathway 4598 2224 4597 9865 PMC7816079__F5 Saponin biosynthetic pathway in P. notoginseng and expression profiles of key enzyme genes.The genes in the green box are the UGT genes identified in this study 4598 4597 3652 6750 9453 667 PMC7816137__F3 Met1-linked ubiquitin machinery in inflammation and infection 81858 90268 1540 9825 29110 PMC7823564__F1 NFKB canonical and non-canonical pathways 1950 4050 1956 4055 958 5971 PMC7824603__F1 An integrated model of the molecular pathway underlying light-mediated seed germination 80119 1605 5863 PMC7827005__F1 Activation of signaling pathways (selected) in MM cells in the BM microenvironment 3479 3717 2475 572 6774 5971 4609 22943 89780 5132 PMC7827203__F3 Crosstalk of MDSC and Treg 6774 3383 941 958 3902 100187761 6352 8942 PMC7827270__F2 Action of Oxaliplatin: L-OHP is transported into the cell by solute carrier family 31 (copper transporter), member 1 (SLC31A1) 1317 2950 2068 2067 7515 PMC7828590__F1 ERA activity through genomic and nongenomic actions 6714 6667 7018 PMC7830632__F1 Apoptosis, inflammation and endoplasmic reticulum (ER) stress regulated by the caspase family 355 581 9447 54867 637 PMC7831272__F7 Proposed model on the epigenetic regulation mechanisms of histone H3K27 acetylation causing the FLHS in laying hens 7018 335 51129 2252 3815 2168 PMC7832239__F1 Crosstalk between complement and coagulation cascade in COVID-19: There are 3 major self-regulating and overlapping pathways of complement activation system 718 730 735 716 PMC7834962__F1 IFN-related signaling pathways modulated by OncoTherad, zinc, vitamin D and glutamine during viral infections 3466 4615 3661 PMC7838037__F5 NF-Kß mediated signaling pathway leading to mucus hypersecretion 1950 1956 6667 4583 4082 100170220 PMC7842006__F3 Ingenuity Pathway Analysis (IPA)-identified immune related gene networks with score > 20 3458 23547 10135 613 152189 65268 9079 55576 PMC7842075__F7 Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma 1506 23788 4318 PMC7843454__F3 Peroxisomal and mitochondrial fatty acid oxidation are dysregulated in both early and late CKD 2108 2109 2548 3033 35 PMC7845653__F3 Podocyte Notch1 signaling in diabetic nephropathy (DN) 387 6010 182 4851 51548 PMC7846875__F10 Schematic drawing to illustrate the inhibitory effect of GPs on NFKB and TNFA signal pathway and inhibitory of apoptosis of endothelial and epithelial cells 7099 4615 3553 7412 PMC7847333__F8 Schematic diagram 50964 1499 4040 4041 PMC7847335__F1 Toll-like receptor-signaling pathway during pulmonary infections 3550 3603 114609 7097 7099 PMC7847636__F3 Canonical Wnt signaling activates DPAGT1 expression and protein N-glycosylation, leading to extensive N-glycosylation of E-cadherin 1798 999 4041 115908 PMC7853129__F6 CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFB 999 6714 4087 7006 100124696 2303 PMC7855613__F4 Glycosylation in oncogenic signaling pathways 1950 2932 324 1499 4089 PMC7857921__F4 Selected pathways up- and downregulated by the additional hemorrhagic shock 7099 929 8754 10333 114609 920 6348 6279 6280 728 PMC7858229__F1 Major forms of inflammatory cell death 8717 8737 841 8772 11035 197259 834 79792 836 1687 PMC7858612__F2 Ferroptosis: mechanisms and links with diseases 5094 55240 2182 100 10162 PMC7859098__F4 m6A modification in immune-related bone homeostasis 7422 56339 5741 5745 7189 PMC7864210__F1 ERA:E2 signaling network and crosstalk with growth factor signaling 6714 2475 7018 PMC7865618__F2 Different treatment strategies to modulate the IL-1–IL-1R pathway 3553 27179 27177 90865 114548 6761 PMC7867260__F2 Biosynthetic pathways branching from glycolysis in glucose-replete conditions 3099 3939 2744 PMC7868022__F1 EBV-induced oncogenesis through the NFKB signaling pathway 28511 54984 1004 PMC7868022__F3 EBV-induced oncogenesis through the JAK/STAT signaling pathway 3718 6774 3142 6689 157848 10018 3566 PMC7868705__F1 Noncanonical NFKB Signaling Pathway in Liver Diseases 3553 4050 7187 5970 5971 PMC7868988__F1 The main cellular pathways regulated by NNMT 23411 952 4837 51199 4397 10135 191 PMC7873640__F1 Detail description of both canonical and noncanonical TGFB signaling and interaction of natural compounds in the regulation of this signaling cascade at various levels 2885 4087 2475 7018 PMC7875152__F2 Genetic causes of PH 2022 659 9496 79572 64321 27302 94 358 3777 857 619537 6833 PMC7875961__F3 Horizontal pleiotropy of common genetic factors 54209 1435 1234 2185 PMC7876357__F5 Hyaluronan, Transforming Growth Factor B, and Extra Domain A-Fibronectin: A Fibrotic Triad 7099 1956 6714 4089 7392 4088 472 4087 6010 5494 4615 25805 PMC7876650__F2 Contrast effects of autophagy in the treatment of bladder cancer 8408 9706 9776 60673 80317 7942 6009 7249 7248 PMC7877171__F3 Molecular mechanism by which intermittent fasting (IF) affects tumor cell growth 23410 3479 10135 3953 56981 639 PMC7878545__F6 Summary of Treg-of-B (P) cell generation and their molecular mechanisms in alleviation of asthmatic inflammation 6778 3902 581 196 PMC7880745__F7 Anti-metastatic Effects of Cationic KT2 Peptide (a Lysine/Tryptophan-rich Peptide) on Human Melanoma A375.S2 Cells 2885 387 3725 PMC7881125__F6 Distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma 2146 6723 27430 1491 4144 191 875 4524 4548 6472 262 PMC7882494__F7 Pathway analysis 3481 2064 2065 27122 27121 3480 5728 8660 4893 3845 8313 324 1499 5295 673 4609 472 7046 7048 92 11200 4087 4088 4089 7157 6197 PMC7882549__F2 Mevalonate pathway and possible mechanism of action of statins 1956 6010 596 581 PMC7884707__F3 Hedgehog (Hh) signaling pathway-mediated therapy resistance in CSCs 8205 3479 6469 3569 51684 2735 2737 2736 11127 PMC7884707__F4 Wnt/Beta-Catenin signaling pathway-mediated therapy resistance in CSCs 1499 64094 999 2011 324 2932 960 5747 3397 30812 607 4040 4041 PMC7885587__F6 Pathway analysis 7422 7040 1950 3479 7048 1956 2064 3480 2100 2099 5241 6885 6714 1645 5174 5606 8648 2475 6009 3984 7471 54361 4609 3400 PMC7886651__F1 Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms 920 3458 6774 50943 2625 6778 3662 604 6772 PMC7890269__F7 Proposed model 7942 2100 367 PMC7892335__F1 Loss and revival of androgen receptor signaling in advanced prostate cancer 367 6790 7157 5925 2146 6657 2303 4803 6935 340075 PMC7892432__F1 Mechanism of pyroptosis affecting alveolar macrophages in ALI 7099 4615 115004 114548 147945 3146 79792 PMC7892432__F2 Mechanism of pyroptosis affecting endothelial cells in ALI 7099 114548 3146 79792 115004 PMC7893032__F2 Cell death in head and neck cancer pathogenesis and treatment 114548 79792 1687 3553 8205 5879 3146 PMC7896225__F1 Proposed neuroprotective role of Withaferin A (WA) in the modulation of pathways implicated in neurological abnormalities and dysfunctions.Parkinson’s disease (PD): WA is a known inhibitor of the Cdc37/Hsp90 complex 11140 120892 6647 PMC7897698__F1 Model summarizing the regulation of MIR211 gene expression: MIR211 gene is nested within the TRMP1 transcript 4286 596 1786 406993 4308 23532 57403 2315 3778 PMC7903614__F6 Primary paracrine and autocrine signalling contributes to cholesteatoma pathogenesis upon activation of the TLR4 pathway 6374 3481 1950 2069 7099 3082 3553 PMC7904157__F5 SlKLUH expression is associated with genes involved in ‘Cutin synthesis and transport’ pathway 2184 1637 1072 PMC7905801__F1 IDO- and cell-mediated immunosuppression 941 3620 324 PMC7906116__F8 Interplay and roles of oxidative stress, toll-like receptor 4 and Nrf2 in trichloroethene-mediated autoimmunity 7099 4615 2810 PMC7912095__F2 Loss of LKB1 drives the tumor immune escape 3845 406952 407050 407051 2146 1786 920 6352 6387 PMC7913947__F1 The kynurenine pathway 4553 8564 23475 PMC7915952__F1 Canonical pathway of microRNA (miRNA) processing 27161 54487 29102 PMC7916890__F2 Amino acids and growth factors-mediated activation of the mTORC1 signaling 201163 79726 84219 54468 6396 8131 10641 23334 6009 153129 PMC7918468__F4 Cellular contributors to tau-dependent degeneration 1524 6376 114548 PMC7920050__F1 Biogenesis of exosomes 4827 100170220 5873 5874 PMC7920452__F4 Representation of the gastrointestinal signaling pathway 10850 898 51289 10344 150 1591 2065 2264 153090 354 6657 3861 10683 3854 7042 25818 PMC7922006__F8 CASR-ROCK-YAP1 signaling pathway in tumor parathyroid cells 846 387 9113 26524 10413 7474 PMC7922135__F8 Hippo signaling pathway in OC (A) The main genes involved in Hippo signaling as regards OC and the associated miRNAs 26524 9113 4485 7157 7008 7161 7003 27113 PMC7923474__F4 Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E 84823 4172 8243 214 3688 7534 6500 1965 PMC7925335__F2 Airway and small intestinal tuft cell signaling 2776 240 4056 2782 51764 6476 64806 346562 1103 5330 3710 29850 3709 56670 1131 1128 1129 PMC7930566__F2 Schematic portrayal of the possible mechanisms of mifepristone as a chemo-sensitizing agent for glioblastoma 581 596 4255 PMC7933466__F1 Metabolites regulating nucleic acid sensing pathways 56670 7098 57506 9817 3661 29110 PMC7933775__F1 Hippo signaling pathway 4771 23286 4485 55233 9113 26524 2736 374 PMC7934645__F2 Regulatory roles and mechanisms of the transcription factor FOXF2 in human diseases 4150 2295 7078 9611 8841 94234 7424 2303 7474 6422 64207 1956 7018 1499 PMC7940178__F1 HCA2 triggers different downstream signaling pathway in different cell types 114548 7038 572 5226 4703 PMC7940512__F1 BM-resident CD69+regulatory T cells (CD69+ Treg) decrease expression of CD39 which is required for the canonical CD39/CD73 adenosine pathway 969 952 5091 201633 3902 11126 PMC7940683__F1 Siglec-G in sepsis 7099 100133941 6714 2932 3091 6774 PMC7942223__F2 One-carbon metabolism, transmethylation reactions, folate cycle, and DNA demethylation 4524 4548 635 4144 27430 191 6996 PMC7943311__F6 Signaling pathways critical for the roles and differentiation of Th9 cells and Treg cells in solid tumor 3574 958 940 355 6778 50943 2475 2308 3091 PMC7947359__F2 BPs in the macrophage polarization 6772 6778 114548 PMC7947863__F2 LncRNAs regulate CRC metastasis through protein binding 85495 641638 100127888 100270680 10381 3181 6477 3190 1499 200933 2475 2113 6935 PMC7955704__F2 EGFRex20ins TKI resistance 1956 2066 1021 PMC7956267__F2 Transcriptional regulation involved in activating salt stress-responsive genes in rice 2077 4602 10664 PMC7956553__F2 Cartoon of major proteins in the wingless-related integration site (Wnt)/Beta-catenin growth pathway 4040 4041 54894 84133 8549 324 1499 PMC7956936__F8 Mechanistic view of anthracycline-induced cardiotoxicity 317 7155 718 730 8772 PMC7957263__F1 Signalling pathways DKK4 involved in different kinds of cancer 27121 619501 324 1499 387 PMC7957739__F1 Dysregulation of signaling pathways by chronic viral hepatitis and epigenetic imprinting impact the secretion of circulating candidate biomarkers to the blood 2719 22943 174 1956 6774 2475 PMC7960610__F2 Schematic presentation of common molecular genetic aberrancies in parathyroid adenoma (PA; left) and carcinoma (PC; right) 5979 1499 324 3727 PMC7961553__F8 AIM2 function in microglia as a negative regulator of EAE 9447 10000 115004 3661 PMC7961911__F5 Network/pathway analyses: KDM1A is directly linked to the androgen receptor signaling pathway (green) and is indirectly linked to the immune response, DNA damage response, and cancer cell cycle pathway, among others 84661 7295 3148 4173 63967 2305 8318 4171 5111 9156 7037 3066 545 11200 472 983 9133 641 898 1869 23028 5901 PMC7962940__F7 Role of miR-548m in regulating EMT in breast cancer 100313772 6591 196 999 405 4318 PMC7963908__F9 TNBS-induced activation of the toll-like receptor (TLR) 4 signal transduction signaling cascade, which leads to the activation of canonical NF-kB pathway 7099 3603 7124 PMC7965781__F1 Control of the insect metamorphic transition by ecdysteroid production and secretion 718 56961 729 PMC7966997__F4 EGFR pathway (Biocarta) shown as an interacting network for samples with maximal (top) or minimal (bottom) PAL in colorectal cancer (left) vs normal colon (right) 1956 1950 2885 50964 5290 3265 5578 5579 6774 6416 PMC7967983__F2 Glycolysis in tumor and tumor microenvironment is associated with immunotherapy resistance 3659 1499 5728 2475 PMC7968485__F1 Ferroptosis: Regulated Cell Death 100 10162 2182 2879 PMC7981165__F2 PI3K/AKT-dominated signaling pathway regulates RUNX2 in PCa 5728 2308 367 PMC7982411__F1 MEK-mitogen activated protein kinase–extracellular signal-regulated kinase (ERK) signaling cascade of the mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3-kinase (PI3K)–AKT-serine/threonine protein kinase Akt pathway 4893 3845 5728 5604 2475 PMC7985188__F1 Data, methods (a) and results (b) for TBNC network identification (A) Workflow of the proposed computational approach 672 100500842 6418 PMC7985688__F6 Illustrative model of the mechanism underlying the neuroprotective effects of PROG and ALLO against ketamine-induced cognitive deficits 10857 1956 627 PMC7986977__F5 Metabolic pathway associations of significantly different metabolites in COVID-19 7166 1644 4129 4128 121278 3620 169355 8564 8942 PMC7987467__F1 Severe SARS-CoV-2 syndrome as a result of hypoxia and HIF-1 signaling pathway activation 7124 6347 718 727 PMC7990371__F3 Directly and indirectly anti-cancer pathways of APN 9099 11197 6774 2931 7249 1499 2475 595 PMC7994325__F2 Importance of ICOS+ Th1 cells in ICI therapy 324 29851 3458 1493 920 PMC7997318__F6 Nrf2 pathway in different liver diseases 9817 619501 4094 PMC7998716__F1 Activation of Tyro3, Axl and MerTK (TAM) receptors on cancer cells results in downstream oncogenic signaling 558 7301 10461 6010 4170 5898 4318 5899 PMC7999177__F2 Transcriptomic alteration-based identification of potential diseases and functions modulated upon leptin upregulation 3552 1513 3952 4314 4318 4322 3569 6356 6374 2252 3934 6288 5743 4321 7474 PMC7999827__F4 Apoptosis and cell death pathway 367 355 637 PMC8000623__F2 Summary of survival tactics of MAH within phagocytes from host innate immune effectors MAH infection 372 8546 9482 1522 3725 PMC8001543__F4 IL-7 effect on restoring 4-1BB signal transducer in HCV-specific CD8 T cells 8178 7185 7040 324 PMC8002730__F4 Core signaling pathways of non-triple negative breast cancer (non-TNBC) 29126 56477 387597 5241 998 2033 11345 367 4609 406982 406952 940 4313 596 58476 6935 7852 57826 PMC8002742__F3 The NLRP3 inflammasome pathway 114548 3553 3606 PMC8004373__F7 Interaction network of CXCR family proteins (cBioPortal) 3577 5290 57007 3579 10020 59345 4882 6697 PMC8004488__F8 Astrocytes morpho-functional alterations in ADLD phenotype 1506 3976 6774 PMC8004548__F1 Interleukin-6 classical and trans-signaling 102 6868 8835 8651 PMC8007386__F6 Model depicting the role for microvillous cells involvement in the olfactory epithelium innate immune response to viral infection 346562 5336 7706 29850 3710 240 55540 5742 64806 PMC8007632__F7 Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGFB1/SMAD2/3 pathway and ABCC1 transactivation 468 7040 7046 PMC8009543__F1 NLRP3 activation 847 4615 57506 9927 10628 114548 3553 PMC8009749__F1 Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance 9314 8651 5728 4697 3667 4827 64781 PMC8010610__F1 RAS Signalling Pathway (90% of JMML cases involve mutations in the RAS pathway): N/KRAS proteins (in Pink) alternate between “ACTIVE” and “INACTIVE” states 3717 2885 5781 9846 3845 4763 2475 PMC8011569__F4 Analysis of gene pathways for MENT, LH alone or in combination (MENT+LH) to regulate steroidogenesis 1583 2230 2232 6770 3283 1586 3293 3295 7923 6715 PMC8012676__F9 Proposed model for effect of GNE mutation on actin dynamics and cell migration 6714 10020 387 PMC8013494__F1 COVID‐19 and Liver Cirrhosis: Focus on the Nonclassical Renin‐Angiotensin System and Implications for Therapy 545 1636 59272 PMC8018074__F8 Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/B‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide 8313 324 2932 1499 3553 6925 4155 4099 10215 6663 116448 PMC8019201__F3 Molecular mechanisms of the role of enhancer of zeste homolog 2 (EZH2) in a polycomb repressive complex 2 (PRC2)‐independent manner 1499 10155 5970 5971 2146 4609 7018 367 3718 6095 2626 6774 PMC8022410__F8 GSK3B rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs 2932 1499 1834 1758 PMC8024183__F7 The differentially expressed genes mapped in p53 signalling pathway, which are upregulated after radiation exposure (highlighted in red) 275 472 545 100 PMC8024517__F1 Proposed mechanisms by which innate immune responses not only induce inflammation but also skew emerging adaptive immune responses towards a response that amplifies myeloid cell activation in mycobacterial IRIS or COVID-19 920 3553 6347 3627 6348 PMC8027849__F1 Resistance to CDK4/6 inhibitors 3082 2475 2260 1017 1019 26272 1021 367 4485 9113 2195 4609 6774 8405 PMC8031259__F2 Insulin signalling pathway and Insulin resistance in COVID-19 and Diabetes infection.Adapted from Jung & Choi (2014), Finucane and Davenport (2020), Rajpal et al 6908 3667 1636 PMC8032583__F1 Serum 4Beta-hydroxycholesterol increases during fluconazole treatment 1595 6713 4047 1718 PMC8034476__F2 Mechanism and regulatory axis of PTHR1 in osteosarcoma 22943 51176 81671 92249 23414 4929 389 3037 PMC8035348__F3 Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma 6239 5163 2146 1786 5728 27250 56667 8651 324 1499 2932 PMC8035348__F4 Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma 10956 5820 999 2146 378938 3205 100316868 100124700 7054 387 143458 693210 100126307 5764 100302208 PMC8037356__F7 The signaling pathway in tested melanoma cells 5728 3611 253260 2475 8408 83939 1977 PMC8038106__F1 Molecular pathophysiology of hereditary hemorrhagic telangiectasia (HHT) 659 4088 4087 5053 PMC8038106__F2 Targets of bevacizumab and tacrolimus 659 4090 4086 55872 PMC8038495__F9 Proposed scenario of the altered mechanisms driven by HFD/IPA treatment 3667 10724 8473 PMC8038663__F1 Chemical structure and mammalian glycosphingolipid (GSL) biosynthetic pathway 7357 7368 9334 8869 9514 2583 6489 84002 53947 PMC8040300__F7 Molecular mechanisms underly GSS against brain injury in tMCAO rats 2937 3553 968 958 PMC8040310__F8 The proposed molecular mechanism highlighting the role of betulinic acid in the pathophysiology of SCI and subsequent neurological recovery 2475 7942 3606 3553 114548 PMC8043893__F9 SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation 146206 8994 6497 26524 PMC8045214__F9 Association of cyclin-dependent kinase inhibitor 2B antisense RNA 1 gene expression and rs2383207 variant with breast cancer risk and survival 367 9055 23492 23512 23090 5978 196 6955 11279 405 6670 4150 4609 2624 10664 7549 162963 58491 PMC8046021__F1 Heparanase triggers multiple pathways that drive myeloma progression 10855 3627 3082 3667 8544 PMC8047077__F7 IFI6 mediated inhibition of HBV replication and gene expression 3466 6772 6773 PMC8050094__F6 Intracellular Ca2+ cycling 759 4018 952 PMC8050411__F6 Enriched canonical pathway of IFN transcriptomic pathway identified by IPA, showing gene expression and predicted relationships between molecules differentially regulated by 311 nm UVB 18 h after irradiation 3458 10379 581 5696 3659 3437 4938 10581 4599 PMC8051073__F4 Ingenuity Pathway Analysis (IPA), prediction network of the T1DM conditions presented in this study with the upregulation (red) of miR-126-5p, IL-7, TNFA, VEGF-C, CXCR1, CXCR2 and glucose 63036 10850 3579 7424 3577 PMC8053626__F6 The mechanism of abnormal cholesterol transport in the 827G cybrids 5465 6256 3156 64240 64241 PMC8056770__F1 Pleiotropic roles of leptin in metabolism, immunity, and cancer 50943 2475 3953 3717 6774 920 9021 PMC8063048__F2 Roles that dopamine receptors play in macrophages 3558 3565 6774 PMC8065509__F2 LTBR signaling pathway in lymphatic endothelial cell (LEC) 4055 7187 7186 8717 PMC8065809__F10 Postulated model for the mechanism underlying IGF-Trap resistance in MDA-MB-231 2260 10818 2885 PMC8066821__F2 Biosynthetic (transsulfuration) and catabolic (oxidation) pathways of H2S 26227 29968 5723 729779 875 58472 847 2937 7263 PMC8068835__F11 Summarized interconnection between PC synthesis, trans-sulfuration pathway, folate cycle, methionine cycle, polyamine pathway, and trypanothion synthesis 5091 10400 907 635 875 PMC8069526__F5 RNAs that regulate nonhomologous end-joining (NHEJ) 693207 574468 108570035 81846 7518 PMC8070386__F2 Influence of extracellular acidification on melanoma progression 4286 558 79923 4318 4313 9314 6657 790 216 PMC8071069__F5 FoxO signaling pathway and Glycolysis/Gluconeogenesis pathway 3479 5728 5934 4616 5105 2645 PMC8073493__F2 Non-Coding RNAs in the Neuroprotective Effects of Glutathione 5266 283120 627 7077 PMC8074600__F1 Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder 324 4040 4041 607 1006 PMC8074600__F2 Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder 6608 51684 6469 50846 3549 5727 2735 2736 2737 PMC8076293__F3 NFKB signalling cascade 5970 57506 7186 7187 115004 5971 5966 PMC8076597__F1 Road of Solid Tumor Survival: From Drug-Induced Endoplasmic Reticulum Stress to Drug Resistance 3297 9531 7494 468 22926 8737 5601 5599 1499 9474 9140 7015 7186 440823 PMC8076900__F1 Control of T Cell Metabolism by Cytokines and Hormones 8140 3575 2475 50615 PMC8082456__F1 Key Role of NAD+ in Anti-Tumor Immune Response: An Update 952 115004 84890 PMC8082835__F7 Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness 3417 27165 2806 2746 84706 PMC8085043__F2 Current Concepts and Advances in Graft-Versus-Host Disease Immunology 9475 2638 695 6774 3716 3717 6850 50615 1435 1436 PMC8085045__F7 Alantolactone inhibits cervical cancer progression by downregulating BMI1 648 6774 11035 1000 PMC8085147__F2 CGAS–STING signaling pathway senses cytosolic DNA derived from either viral/bacterial infection or self-DNA 115004 3661 3569 7124 PMC8085163__F1 Isoprenoid biosynthetic pathway 5906 3652 2224 PMC8085551__F6 Transcriptomic and Metabolomic Profiling Reveals the Protective Effect of Acanthopanax senticosus (Rupr. & Maxim.) Harms Combined With Gastrodia elata Blume on Cerebral Ischemia-Reperfusion Injury 3242 5053 123099 7083 10201 56624 4507 PMC8085803__F2 Immunoceptive inference: why are psychiatric disorders and immune responses intertwined? 1392 3458 7124 PMC8093649__F6 Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases 958 7186 5879 PMC8094936__F8 Encephalomyocarditis Virus Abrogates the Interferon Beta Signaling Pathway via Its Structural Protein VP2 7189 57506 7187 10010 3661 PMC8099713__F1 Sensing of RNA virus invasion by RLRs and TLRs 100187761 7189 57506 7187 29110 3661 3665 1283 7098 51311 51284 4615 PMC8099713__F3 Antagonizing IFN-mediated immune responses by coronavirus 3454 3455 6772 6773 7297 3716 10379 83939 3665 9636 PMC8099739__F2 VB10, a new blood biomarker for differential diagnosis and recovery monitoring of acute viral and bacterial infections 9636 64135 1499 860 3458 4856 PMC8100301__F6 Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19 572 836 2169 5743 1909 PMC8103031__F3 CBP-JMF: An Improved Joint Matrix Tri-Factorization Method for Characterizing Complex Biological Processes of Diseases 2064 2065 4602 7410 5881 9261 5163 994 PMC8105775__F2 Caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems 7054 594857 6588 PMC8106838__F1 An overview of Notch maturation, activation and processing 6868 6476 3516 PMC8106838__F2 Skin architecture and Notch pathway member distribution 4854 4855 4851 28514 4853 PMC8108610__F1 Entry, egress and vertical transmission of SARS-CoV-2 7113 59272 5478 PMC8110983__F2 Tumour-derived factors associated with cachexia in pancreatic adenocarcinoma 51284 2475 4852 181 5443 6774 3553 7054 7124 7350 PMC8113731__F1 Mitotic kinases as drivers of the epithelial-to-mesenchymal transition and as therapeutic targets against breast cancers 2932 5747 699 4751 PMC8113755__F1 WNT plasma membrane signaling in PDAC 64840 54894 55366 8549 324 847 4609 1499 2932 2475 7248 4040 4041 PMC8114918__F6 Schematic figure showing the possible contribution of miR-506 to phenotypic presentation of colitis in patients with PSC + UC compared to those with UC alone 100653366 1786 8877 PMC8115215__F8 PSA regulatory mechanism of VRC metabolism 1557 3553 7189 4615 PMC8117014__F4 Research Progress of circRNAs in Head and Neck Cancers 26033 317 5728 5159 637 94234 1950 1956 494334 51232 PMC8117096__F3 CGAS-STING Pathway: Novel Perspectives in Liver Diseases 3661 29110 115004 PMC8120202__F3 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS 7506 2353 3146 100126309 PMC8120202__F4 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS 967 5728 7415 128869 6714 378 PMC8120550__F8 Overexpression of ING3 is associated with attenuation of migration and invasion in breast cancer 6608 177 5970 5966 7142 6770 PMC8122057__F4 Interleukin (IL)-4 signaling sources (A) and targets (B) 3566 2625 57379 6778 PMC8123704__F5 Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway 4615 51135 3654 3553 PMC8124199__F2 JAK/STAT Molecular Pathway in Vascular Remodeling Associated with Pulmonary Hypertension 3716 3717 6774 7297 6772 PMC8124588__F1 Anaphylaxis: Focus on Transcription Factor Activity 3815 2625 2623 2624 6774 85480 117194 4286 7030 7942 PMC8126205__F6 Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population 8517 3551 7099 7421 929 10410 PMC8127420__F4 Epidemiological link between obesity, type 2 diabetes mellitus and cancer 3479 23411 4041 1499 2932 51176 PMC8127498__F8 Tissue-specific transcriptome analyses reveal candidate genes for stilbene, flavonoid and anthraquinone biosynthesis in the medicinal plant Polygonum cuspidatum 4598 10654 4597 PMC8128161__F2 ER protein quality control capacity in metazoans is monitored by the three branches of the unfolded protein response 22926 7494 83939 468 PMC8128982__F4 Depicting the proposed pathogenesis of MIS-C with COVID-19 (the proposed pathogenesis is a constellation of various hypotheses referred accordingly) 7124 3460 51744 3916 3661 6364 56477 4585 143662 5132 4553 5025 9718 161198 7422 PMC8129319__F5 WW45 inhibits breast cancer cell proliferation by the Hedgehog signaling pathway 6608 6469 2735 64399 PMC8131930__F3 Aspergillus fumigatus and aspergillosis: From basics to clinics 404713 2147 717 PMC8132252__F2 Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19 8066 81792 7450 5091 95 PMC8143163__F1 Impact of H2S on Obesity-Associated Metabolic Disturbances 1610 4357 847 4524 875 51380 1491 PMC8146082__F2 Unfolded Protein Response: An Overview 468 467 83939 PMC8146599__F3 Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process 51129 9518 3569 3586 PMC8147235__F2 Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation 149233 2475 114548 PMC8147772__F2 Control of Macrophage Inflammation by P2Y Purinergic Receptors 7099 4615 6868 PMC8147772__F3 Control of Macrophage Inflammation by P2Y Purinergic Receptors 7099 4615 6772 PMC8151045__F1 PD-1 and LAG-3 Checkpoint Blockade: Potential Avenues for Therapy in B-Cell Lymphoma 920 941 940 PMC8151911__F2 Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review 7189 6774 2638 2669 122199 100616491 PMC8155577__F2 Ancient Adversary – HERV-K (HML-2) in Cancer 7098 3661 3665 3586 57506 51311 7018 367 4193 1499 PMC8156432__F8 Orai1 Channel Regulates Human-Activated Pancreatic Stellate Cell Proliferation and TGFB1 Secretion through the AKT Signaling Pathway 100653366 7040 84876 6786 PMC8156814__F5 Antitumor Activity of Nitazoxanide against Colon Cancers: Molecular Docking and Experimental Studies Based on Wnt/Beta-Catenin Signaling Inhibition 836 842 572 324 6010 595 PMC8161522__F3 Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models 2932 1859 100170220 4852 2022 266743 5972 387 7054 7083 7018 PMC8165189__F1 Hippo Signaling Pathway in Pancreas Development 3651 6662 256297 1357 4485 9113 PMC8165189__F2 Hippo Signaling Pathway in Pancreas Development 4781 26524 9113 133 PMC8165473__F2 Anti-inflammatory and Proangiogenic Properties of High-Density Lipoproteins: An Emerging Role in Diabetic Wound Healing 7412 3383 7124 6347 2919 PMC8168453__F4 Schematics of the TIM3/Gal9 pathway in innate immune cells 324 3458 8205 7099 PMC8169418__F1 Effect of COVID-19 on NFKB and Neurological Manifestations of Disease 7098 51284 7113 59272 PMC8176883__F3 Proteomics-Based Insights Into the SARS-CoV-2–Mediated COVID-19 Pandemic: A Review of the First Year of Research 847 8634 26058 4627 PMC8176995__F3 Can Some Anticancer Treatments Preserve the Ovarian Reserve? 652 3815 3976 5728 6194 PMC8178461__F1 Roles of PD-1/PD-L1 in the prognosis and immunotherapy of prostate cancer 84918 1499 6774 5728 3976 PMC8181394__F2 Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy 6713 3156 38 PMC8181875__F1 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer 2920 100653366 3603 3717 6774 PMC8181875__F4 Novel therapies targeting hypoxia mechanism to treat pancreatic cancer 29128 23409 9112 1956 5049 55534 6608 3146 3315 23411 7019 5091 PMC8182917__F1 Estrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment 1499 2625 3169 2078 PMC8184806__F6 SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions 466 3315 7124 1636 PMC8185227__F3 LncRNAs in the Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma 1958 6774 3717 84793 22943 3170 643911 1024 6935 4040 1499 100270680 5728 100128191 221937 26255 2475 9232 649 100133311 154860 10514 PMC8185253__F11 Assessment of Significant Pathway Signaling and Prognostic Value of GNG11 in Ovarian Serous Cystadenocarcinoma 1101 4863 7450 1758 1832 960 948 961 PMC8185703__F1 LZTR1: A promising adaptor of the CUL3 family 8452 2147 8036 PMC8185703__F2 LZTR1: A promising adaptor of the CUL3 family 6016 3845 8452 3265 6237 4763 PMC8190078__F6 RANKL immunisation inhibits prostate cancer metastasis by modulating EMT through a RANKL-dependent pathway 6714 1499 2932 PMC8190251__F3 Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock 64802 349565 23057 10135 23411 952 PMC8193053__F9 Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages 114548 3929 929 7099 4615 3654 51135 7189 8772 PMC8193943__F2 Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy 64750 9958 5970 4092 4091 9618 9817 6047 26994 PMC8194090__F2 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation 4040 4041 1499 324 2932 6662 860 650 PMC8194090__F5 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation 4087 4088 6662 860 PMC8194282__F2 Neuroinflammation in Post-traumatic Epilepsy 4615 7099 4087 4088 PMC8194945__F1 Nephroprotective activity of natural products against chemical toxicants: The role of Nrf2/ARE signaling pathway 9817 3553 9978 4094 PMC8195904__F2 Adamantinomatous craniopharyngioma as a model to understand paracrine and senescence-induced tumourigenesis 1499 324 54894 7939 84133 PMC8197279__F2 Damage-Associated Molecular Patterns Modulation by microRNA: Relevance on Immunogenic Cell Death and Cancer Treatment Outcome 3146 100616179 442899 22937 PMC8197527__F6 Carcinogenesis of Triple-Negative Breast Cancer and Sex Steroid Hormones 367 999 6935 PMC8198587__F3 Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression 4040 4041 10524 8607 1499 51176 PMC8198784__F1 Not Only Immune Escape—The Confusing Role of the TRP Metabolic Pathway in Carcinogenesis 6999 8564 3620 169355 23475 PMC8199989__F2 HECT-Type E3 Ligase in the Development of Cardiac Disease 4040 4041 2932 1499 83737 51548 10628 332 488 PMC8204759__F1 Golgi-localised components that mediate mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) signalling 100187761 6009 5861 375 10494 64083 PMC8207884__F4 Correlation Between the Evolution of Somatic Alterations During Lymphatic Metastasis and Clinical Outcome in Penile Squamous Cell Carcinoma 7157 472 351 253260 238 3845 5728 7248 2475 50964 3265 369 3815 203447 PMC8208619__F6 CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition 7852 6476 2475 PMC8212127__F4 Insulin-Like Growth Factor Pathway and the Thyroid 947 958 3479 PMC8212140__F3 Reactive oxygen species produced by altered tumor metabolism impacts cancer stem cell maintenance 3099 960 4609 PMC8213534__F2 TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review 7098 148022 57506 PMC8214167__F6 Innate immune response analysis in COVID-19 and kawasaki disease reveals MIS-C predictors 3454 6772 7124 3455 6773 57162 29110 3665 3654 7097 4615 51135 3661 7098 3428 51284 51311 834 6774 114548 80271 PMC8214786__F7 Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect 4280 6774 196 PMC8217435__F3 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far 4615 7098 3661 7187 3665 29110 57506 PMC8217435__F4 Inhibition of the IFN Response by Bluetongue Virus: The Story So Far 57506 29110 3661 3665 7297 3454 3455 3716 6773 6772 10379 163702 3459 3460 PMC8220440__F2 Multifunctional inhibitors of SARS-CoV-2 by MM/PBSA, essential dynamics, and molecular dynamic investigations 7124 8717 10682 3553 3976 PMC8220440__F3 Multifunctional inhibitors of SARS-CoV-2 by MM/PBSA, essential dynamics, and molecular dynamic investigations 7124 7185 7186 7187 PMC8221416__F2 NLR signalling pathway 10392 64127 3725 22861 3553 PMC8221416__F3 TLR signalling pathway 7096 7097 7098 3661 54106 3665 10333 51311 51284 4615 7100 7099 PMC8221613__F1 General schematic of astrocyte reprogramming using TFs and miRNAs 6657 429 442912 PMC8222406__F10 CSC-associated AKT/TSPYL5/PTEN loop signaling pathway 1956 85453 5728 216 220 960 PMC8222669__F6 Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases 9817 2475 6774 3717 PMC8223458__F5 Long non‐coding RNA HOTAIR/microRNA‐761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma 100124700 27161 100313892 51400 PMC8227550__F3 RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling 114548 29110 3661 57506 3665 PMC8229730__F2 New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes 6774 9021 7536 3953 2308 PMC8230033__F1 Altered Bone Status in Rett Syndrome 860 4204 759 6424 7475 4038 1499 4040 4041 PMC8230471__F8 Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy 3479 3667 8660 572 1950 2475 PMC8232256__F4 Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma 6347 729230 7054 2920 PMC8235118__F8 Mitochondrial Function Are Disturbed in the Presence of the Anticancer Drug, 3-Bromopyruvate 2597 6647 6648 4149 PMC8238072__F1 Experimental Drugs for Chemotherapy- and Cancer-Related Anemia 4087 4088 6774 3569 PMC8239365__F5 IGFBP2 Is a Potential Master Regulator Driving the Dysregulated Gene Network Responsible for Short Survival in Glioblastoma Multiforme 3716 3717 9180 6774 7422 6772 4318 4313 1956 3480 3725 3485 5154 5728 207 2475 165 PMC8239905__F3 COVID‐19‐related coagulopathy: A review of pathophysiology and pharmaceutical management 1636 7018 727 PMC8240065__F4 Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles 8773 962 7099 4615 4067 51135 3654 7189 2002 6347 7097 1380 1378 3553 6352 6354 2920 PMC8247436__F4 Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection 958 100507436 4615 PMC8250126__F1 Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection 3716 3717 59272 7124 PMC8250149__F3 NLRC5: A Potential Target for Central Nervous System Disorders 7422 595 1499 619501 84166 PMC8256170__F2 OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases 324 643 7186 PMC8262608__F1 Interleukin-1- Receptor Kinase 4 Inhibition: Achieving Immunomodulatory Synergy to Mitigate the Impact of COVID-19 7096 7100 7097 10333 51135 7099 4615 7189 90865 51284 51311 PMC8262770__F2 Metabolic Control of Smoldering Neuroinflammation 948 54209 348 7305 2475 2171 4023 64805 338773 1524 23152 47 PMC8263653__F14 Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture 3630 444 102 8754 8038 8751 6714 PMC8267409__F2 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects 9839 2475 6774 100124700 11054 64422 10533 6935 55544 4513 23326 23411 728655 5728 PMC8267409__F3 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects 27044 8091 5080 27161 100316868 1719 9839 596 PMC8267409__F4 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects 4193 55384 6774 3717 127 4072 2475 5728 2146 PMC8267719__F3 Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions 2475 5728 60674 2308 PMC8267830__F2 Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network 253260 64798 2932 5728 2887 PMC8268178__F1 Connecting Cholesterol Efflux Factors to Lung Cancer Biology and Therapeutics 335 10948 4864 5174 PMC8268587__F1 Osteoblast Differentiation and Signaling: Established Concepts and Emerging Topics 4089 4090 4086 25805 4091 22943 51232 4040 4041 6423 1499 324 79412 PMC8269070__F4 Dexamethasone for Severe COVID-19: How Does It Work at Cellular and Molecular Levels? 7018 6772 6773 3661 23426 PMC8269285__F10 Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma 467 7422 4118 2147 100187761 5978 PMC8269379__F1 New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent 196 1545 15 438 PMC8273223__F1 Etoposide, an anticancer drug involved in therapy-related secondary leukemia: Enzymes at play 7361 1576 4353 2950 2952 PMC8274167__F1 Metabolic regulators of enigmatic inflammasomes in autoimmune diseases and crosstalk with innate immune receptors 114548 79792 58484 4671 4049 22861 3553 920 171389 9447 197358 7189 57506 79671 PMC8275185__F5 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant 23179 5863 57139 PMC8275185__F8 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant 578 51411 1362 PMC8275185__F11 Transcriptome Analysis of Chloris virgata, Which Shows the Fastest Germination and Growth in the Major Mongolian Grassland Plant 6500 65989 27040 PMC8275893__F2 TCF7L2 in Type 2 Diabetes 6259 2932 4040 4041 960 324 PMC8275893__F3 TCF7L2 in Type 2 Diabetes 4040 4041 2932 324 PMC8277227__F1 Interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis 4615 3146 3553 PMC8279385__F2 Specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development 64806 90865 3596 260431 PMC8279913__F2 Current therapeutics against HCV 57506 7189 7098 PMC8282123__F1 Endocrine Influence on Cardiac Metabolism in Development and Regeneration 95 6957 6955 2638 PMC8282538__F5a Molecular processes mediating hyperhomocysteinemia-induced metabolic reprogramming, redox regulation and growth inhibition in endothelial cells 178 11067 230 10206 23089 7063 64847 9590 64321 23555 10626 PMC8284850__F5 Intratumoural fibroblast heterogeneity in pDaC 3976 6469 920 3596 51135 6387 5156 960 6772 6774 PMC8288060__F7 Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated 324 22943 1499 PMC8292097__F10 Carbon Monoxide-Releasing Molecule-2 Ameliorates Particulate Matter-Induced Aorta Inflammation via Toll-Like Receptor/NADPH Oxidase/ROS/NFKB/IL-6 Inhibition 7097 7099 7412 3383 PMC8293989__F1 Comparisons of Underlying Mechanisms, Clinical Efficacy and Safety Between Anti-PD-1 and Anti-PD-L1 Immunotherapy: The State-of-the-Art Review and Future Perspectives 324 941 942 940 PMC8298376__F5 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids 4049 5970 6418 6476 7054 8738 581 7157 8837 8739 54205 355 828 26136 572 PMC8299307__F6 Schematic diagram demonstrating the novel signaling pathway involving EGFR–TRPM7 interaction in VSMCs 54822 1950 1956 PMC8300228__F2 Antimicrobial Peptides from Black Soldier Fly (Hermetia illucens) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming 4615 8772 23118 PMC8301062__F2 GSK-3B in Pancreatic Cancer: Spotlight on 9-ING-41, Its Therapeutic Potential and Immune Modulatory Properties 2932 3902 545 PMC8301407__F3 Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway 3620 169355 8564 PMC8303169__F2 Pivotal Player: Components of NFKB Pathway as Promising Biomarkers in Colorectal Cancer 7124 5970 5971 PMC8303169__F3 Pivotal Player: Components of NFKB Pathway as Promising Biomarkers in Colorectal Cancer 3845 1956 10419 6774 PMC8303609__F4 KIR Receptors as Key Regulators of NK Cells Activity in Health and Disease 7535 6850 27040 2885 3135 PMC8304605__F3 Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease 2735 3845 2736 1499 6925 PMC8306262__F3 Statins: a repurposed drug to fight cancer 6010 22937 3652 3156 3949 PMC8306345__F6 Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis 3553 79792 114548 4615 7124 3569 6347 7099 PMC8306954__F2 Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19 59272 7187 114548 7124 197259 PMC8307963__F2 Syndromes of Thrombotic Microangiopathy: A Critical Appraisal on Complement Dysregulation 718 721 735 4179 PMC8313993__F1 Metabolic pathway map illustrating high-value bioactive ingredients for food, agricultural feed materials, human health, and well-being products, provided by Corynebacterium glutamicum cell factories 412 4282 3652 5624 PMC8314420__F2 Genetic syndromes with vascular malformations – update on molecular background and diagnostics 2022 2658 4089 238 4090 4086 PMC8317513__F5 FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/Beta-Catenin Signaling Pathway 4040 4041 8312 324 1499 2932 1019 4316 595 51176 6925 2273 PMC8319800__F3 Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models 1641 3146 114548 7124 PMC8321659__F9 Scheme showing the main alterations found in aging neurons in vitro 2475 4864 6721 PMC8326263__F3 Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management 3605 6370 2475 7450 PMC8327086__F8 Berberine Reduces AB42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress 351 4280 7038 2932 1998 23621 PMC8328045__F3 Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron 7099 4615 8011 114548 6850 3383 7412 PMC8332860__F6 Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells 4018 5447 5228 2147 4025 4254 790 867 7054 1398 1610 5972 51684 2669 6608 5979 4099 4342 100187907 266710 100188776 367 572 8772 545 PMC8335696__F3 Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway 4312 5594 1956 2597 5595 3383 7412 4314 1432 PMC8340210__F1 Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations 6741 142 100187761 672 580 79728 55120 51755 5889 83990 675 472 1111 545 8438 11200 PMC8340306__F1 CGAS-STING signalling in liver diseases 6772 6773 3661 3454 3716 115004 29110 7297 PMC8342713__F7 Inhibitory mechanism of APG-1252 and gemcitabine against nasopharyngeal carcinoma 999 3717 6774 PMC8347056__F3 Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology 84876 6786 80228 93129 PMC8348825__F2 Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta 7038 604 5617 PMC8349295__F7 Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway 9817 2940 3162 PMC8353790__F1 Adiponectin in psoriasis and its comorbidities: a review 1869 3569 149233 PMC8353874__F2 Triple-negative breast cancer: understanding Wnt signaling in drug resistance 1956 1499 2627 1950 2885 5728 6935 2475 4582 999 117581 7291 6774 PMC8358430__F1 Inflammatory Cytokine Storms by Mesenchymal Stem Cells 9242 3717 6774 836 PMC8358691__F1 Physiological impact of in vivo stable isotope tracing on cancer metabolism 5091 2638 2744 PMC8358831__F3 Emerging Perspectives on Leukemia Inhibitory Factor and its Receptor in Cancer 23513 4485 9113 26524 3976 3977 374 PMC8358851__F1 Drivers of phenotypic variation in cartilage: Circadian clock genes 406 9575 4862 1628 1611 PMC8360401__F2 Ischemic postconditioning for stroke treatment: current experimental advances and future directions 7097 7099 51135 596 1499 3553 3383 2475 572 PMC8360640__F2 Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma 6387 7852 154 6774 4804 4803 4318 3082 PMC8361364__F1 Interconnections Between Somatic and Ovarian Aging in Murine Models 3815 2475 5728 PMC8371405__F3 Long Non-coding RNAs on Bladder Cancer 2932 652995 5966 6657 1874 2146 100506885 80312 7503 4089 26220 3191 6347 PMC8371477__F2 Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease 3037 25937 2064 2066 652 121643 PMC8374049__F2 Inflammasome Signaling: A Novel Paradigm of Hub Platform in Innate Immunity for Cancer Immunology and Immunotherapy 56169 79792 1687 55876 7054 PMC8374895__F9 miR-200a-3p Attenuates Coronary Microembolization-Induced Myocardial Injury in Rats by Inhibiting TXNIP/NLRP3-Mediated Cardiomyocyte Pyroptosis 114548 10628 79792 PMC8375232__F4 Functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma 8661 1982 51441 PMC8375323__F9 TIMM17A Regulatory Network Contributing to Breast Cancer 10024 898 7153 64710 641 2305 1111 23397 64151 1062 29128 8833 699 9493 10606 899 3161 990 9787 983 4085 8438 1870 7083 3833 4751 995 993 51514 991 891 6905 51434 1869 890 5347 2146 332 22974 4605 9833 57405 4691 81624 55746 6241 4171 PMC8378592__F2 Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways 3566 8027 10379 10750 6348 3458 59272 3603 1440 PMC8379492__F9 Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies 2308 3156 7038 PMC8382288__SF1 Dual regulation of osteoclastogenesis and osteogenesis for osteoporosis therapy by iron oxide hydroxyapatite core/shell nanocomposites 7189 4772 9242 650 654 4091 4092 PMC8384742__F1 Gastrointestinal mucosal immunity and COVID-19 59272 7113 2592 920 3458 50943 PMC8385797__F5 Smoking induces sex-specific changes in the small airway proteome 718 727 1604 2271 10272 9806 PMC8387187__F8 Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis 929 3717 6774 9021 PMC8387325__F2 Recent findings within the C. elegans neuro-gut axis 4881 4852 6446 PMC8388496__F4 Comprehensive Transcriptomic Comparison between Porcine CD8− and CD8+ Gamma Delta T Cells Revealed Distinct Immune Phenotype 7006 100124696 5603 4690 868 3595 29851 5295 1435 2690 3932 959 8792 940 3458 926 7124 925 6375 3604 356 355 10663 2833 1524 6360 939 10803 414062 118788 974 930 6850 7410 4792 PMC8389562__F3 Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer 574468 693184 100302240 100500882 7675 100422897 8473 57646 4609 100188847 79727 389421 57650 145270 8450 PMC8391142__F1 The Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers 6497 4851 3491 960 100133941 79923 6662 6657 4363 9429 6608 PMC8391356__F5 Galanin during Bacterial Infection in Larval Zebrafish 10803 2829 3565 50615 3569 3597 5617 1441 3572 3589 3595 9180 3587 53832 23765 1436 2475 7124 355 4804 959 4170 2670 7046 7048 PMC8391952__F1 Erythropoietin (EPO) as a Key Regulator of Erythropoiesis, Bone Remodeling and Endothelial Transdifferentiation of Multipotent Mesenchymal Stem Cells (MSCs): Implications in Regenerative Medicine 2056 100038247 5979 PMC8393605__F2 Exploring the Interplay of Telomerase Reverse Transcriptase and Beta-Catenin in Hepatocellular Carcinoma 1499 6925 9314 324 2932 7015 PMC8393646__F9 Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2 6472 100187907 4524 PMC8394846__F1 NFKB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models 4050 5966 5971 602 1540 PMC8394908__F3 Splicing factor mutations in hematologic malignancies 6427 1025 26019 5976 2077 56257 9775 4116 65109 PMC8395128__F3 Regulatory Role of microRNAs Targeting the Transcription Co-Factor ZNF521 in Normal Tissues and Cancers 25925 619501 768219 860 PMC8396260__F9 Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NFKB Signaling through PTEN Activation in Hepatocellular Carcinoma 999 5728 1000 PMC8396471__F2 Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players 4088 4087 1499 6469 7124 4312 4316 9332 7097 9049 100188011 PMC8399070__F1 Nanocarriers as a Tool for the Treatment of Colorectal Cancer 8772 355 637 581 PMC8399337__F1 Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities 3553 3569 4087 4089 4088 1956 2932 1499 6935 PMC8400927__F10 Cell communication analysis results for integrated choroid plexus and brain parenchyma cell types 4900 7432 22987 6750 PMC8402498__F11 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions 92359 8573 6010 2011 5872 7414 9863 5728 100170220 57061 1311 PMC8403172__F7 The proposed regulatory mechanism of ARRB1 in this study 468 83939 7124 PMC8404464__F4 Network medicine in Cardiovascular Research 3586 4739 5709 5053 PMC8415109__F3 Non-coding RNA Activated by DNA Damage: Review of Its Roles in the Carcinogenesis 647979 59341 387 6093 5829 PMC8415555__F9 Effect of tonB Gene on the Virulence of Pseudomonas plecoglossicida and the Immune Response of Epinephelus coioides 1509 1508 7124 811 1431 2271 790 PMC8416371__F9 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis 7006 100124696 2618 7124 8717 8195 4149 351 PMC8417591__F2 Extracellular Vesicles in Sickle Cell Disease: Plasma Concentration, Blood Cell Types Origin Distribution and Biological Properties 7018 7099 114548 3383 7412 834 PMC8417882__F4 Harnessing TRAIL-Induced Apoptosis Pathway for Cancer Immunotherapy and Associated Challenges 5728 572 6009 2475 1977 PMC8427595__F7 Dengue Virus Dysregulates Master Transcription Factors and PI3K/AKT/mTOR Signaling Pathway in Megakaryocytes 7173 2475 2624 PMC8430477__F3 New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway 8737 11035 197259 PMC8432043__F1 Exploring the pathways to chronic lymphocytic leukemia 7474 6387 10563 952 7852 643 5727 8643 6348 6346 6608 4919 6351 960 1236 958 7412 1233 6366 6363 1230 PMC8436187__F3 Release and activity of SQSTM1 in mouse sepsis 7099 4615 340061 8878 3643 79792 PMC8446275__F2 Tissue Specific DNA Repair Outcomes Shape the Landscape of Genome Editing 53335 80184 2184 PMC8448164__F3 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action 2475 7249 7248 3480 572 2064 1956 2065 5163 PMC8448164__F5 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action 1499 4040 4041 324 PMC8449055__F2 New strategies for targeting kinase networks in cancer 780 558 673 1956 PMC8450413__F1 Epigenetic Regulation of the Wnt/Beta-Catenin Signaling Pathway in Cancer 4040 1499 54894 84133 324 8549 5218 2932 PMC8453085__F5 Th17 Cells in Periodontitis and Its Regulation by A20 114548 834 8737 79792 PMC8455332__F1 Suppressive actions of regulatory T cells 1493 941 942 324 PMC8457865__F8 WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M 5008 51384 6774 9180 6464 PMC8458276__F6 Different MMR excision-resynthesis pathways 5111 9156 5426 PMC8461076__F7 Effect of MAP3K8 on Prognosis and Tumor-Related Inflammation in Renal Clear Cell Carcinoma 23111 22944 238 369 3815 4117 5921 2040 4771 PMC8462294__F2 Progression on the Roles and Mechanisms of Tumor-Infiltrating T Lymphocytes in Patients With Hepatocellular Carcinoma 1499 6774 920 50943 PMC8462485__F9 Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NFKB/NLRP3 Pathway 958 7099 114548 941 942 3553 920 PMC8465622__F1 Repurposing Small Molecules to Target PPARG as New Therapies for Peripheral Nerve Injuries 387 6774 2596 960 PMC8466051__F2 VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles 4851 3516 7409 PMC8466058__F1 Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation 4851 102 3280 23462 PMC8468752__F2 Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia 1576 54658 1636 64240 64241 9429 1558 8647 5243 PMC8468898__F4 Validation and Selection of New Reference Genes for RT-qPCR Analysis in Pediatric Glioma of Different Grades 3098 2597 5315 2539 2194 31 7086 47 6319 1431 2271 PMC8471964__F6 Idebenone Decreases AB Pathology by Modulating RAGE/Caspase-3 Signaling and the AB Degradation Enzyme NEP in a Mouse Model of AD 6868 351 23621 PMC8473743__F5 Utilizing Network Pharmacology to Explore the Possible Mechanism of Coptidis Rhizoma in Kawasaki Disease 5970 7157 7048 2260 4843 51135 29110 836 3551 207 2475 2261 5290 5879 5743 3326 PMC8476122__F2 Pembro enhances Gln uptake/release of glutaminolytic products while blocking Gln-fueled Krebs cycle activity in primary CA but not in NC lung tissues 717 718 2744 727 PMC8476494__F8 Hypothalamic-pituitary adrenal-axis, toll-like receptors, and macrophage polarization in pre-atherosclerotic changes induced by social isolation stress in mice 7099 7412 3383 PMC8476858__F1 Editorial: Intracellular Mechanisms of Alpha-Synuclein Processing 1509 2629 9529 5763 PMC8476871__F1 NFKB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites 958 4055 5971 5970 8717 8772 7124 54472 7189 4615 PMC8476871__F2 NFKB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites 7099 7096 4615 114609 7097 3611 51083 54106 PMC8478560__F2 Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer 400619 252983 7163 84740 100506696 100124700 3236 572 7874 108570035 100505817 100506190 1499 PMC8479196__F1 Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy 2194 948 9242 PMC8479803__F1 Vascular smooth muscle cells in atherosclerosis: time for a re-assessment 968 948 3958 9314 335 286205 6943 860 6662 59 93649 6876 4629 PMC8481092__F1 MiR-2392 in driving SARS-CoV-2 infection 351 5210 6010 5315 4536 4538 100616495 PMC8481335__F1 Core mechanisms of ferroptosis 948 2182 2180 150696 55847 10162 9054 2181 4057 4353 5447 7018 3934 7157 4780 8398 23657 6520 2879 1723 3309 84883 2643 PMC8481335__F4 Endoplasmic reticulum in ferroptosis 9451 6720 2182 6319 83939 468 10162 2475 2181 79094 6794 9817 3164 23657 6520 2879 340061 55669 9927 7922 115004 9709 1508 PMC8481630__F7 BRCC3 Promotes Tumorigenesis of Bladder Cancer by Activating the NFKB Signaling Pathway Through Targeting TRAF2 8772 8717 7186 79184 PMC8482189__F3 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas 4853 8115 613 84433 4615 958 9020 7187 330 10365 7128 PMC8482189__F4 New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas 10365 28442 28395 7128 330 7187 4851 4853 7157 4615 PMC8483511__F3 Molecular pathways linking the CD137 signaling pathway to ECs 54790 596 581 4090 4086 4772 PMC8488570__F3 The CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting 6347 6774 729230 2475 PMC8491233__F2 Mitochondria as a target in cancer treatment 5728 2271 1956 PMC8493399__F8 Cyy260, a novel small molecule inhibitor, suppresses non-small cell lung cancer cell growth via JAK2/STAT3 pathway 836 581 2475 3717 6774 PMC8496196__F9 CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner 2052 998 5218 PMC8496250__F1 Biological Significance of Long noncoding RNAs Dysregulation and their Mechanism of Regulating Signaling Pathways in Cervical Cancer 10023 23401 57291 324 595 1499 2475 PMC8496745__F1 How Oncogenic Viruses Exploit p62-Mediated Selective Autophagy for Cancer Development 672 5888 165918 9817 373 29110 115004 8408 PMC8497755__F2 Metabolic Modifications, Inflammation, and Cancer Immunotherapy 4615 7099 64429 3661 64127 79844 6774 PMC8499579__F7 Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer 3627 6352 29110 3661 115004 PMC8501670__F3 Caenorhabditis elegans as a model for obesity research 355 2195 120114 79633 PMC8502122__F1 Comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori 2875 7808 5814 PMC8503187__F1 Biased Ghrelin Receptor Signaling and the Dopaminergic System as Potential Targets for Metabolic and Psychological Symptoms of Anorexia Nervosa 4160 23237 4852 5443 181 PMC8504146__F5 Non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential 759 2022 7939 PMC8505648__F4 Targeted therapy of BCBM treatment 2475 7422 1021 1019 PMC8505796__F3 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer 367 4763 6667 2475 3082 2885 220 57291 1649 6774 121838 PMC8505811__F2 Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease 4088 260431 1431 7189 PMC8507869__F3 Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring 1956 3845 673 238 6098 5979 4914 2475 5728 558 595 894 898 1019 7157 5925 PMC8508344__F1 Estrogens and the Schrödinger’s Cat in the Ovarian Tumor Microenvironment 412 1583 1586 3284 1588 3292 PMC8508851__F13 Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey 4193 472 5728 PMC8508861__F3 Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer 637 581 8772 8717 PMC8509209__F6 LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures 1499 2932 324 999 PMC8509622__F3 Epoxyeicosatrienoic Acids and Fibrosis: Recent Insights for the Novel Therapeutic Strategies 4088 7225 4775 387 PMC8514054__F1 JAK-STAT pathway mutations and variants in human disease 7297 3716 3717 6778 3718 7173 2056 6777 6776 6775 6774 6773 6772 PMC8516279__F7 Signal and interaction networks of CD36 8694 2168 84343 2167 11001 55902 948 6714 5465 335 5360 131578 338 55576 114905 1387 5468 79736 22798 23166 10628 929 7369 7099 1499 10333 389692 114548 999 7097 23643 84872 54148 1500 5733 80351 PMC8516728__F1 Triumvirate of NFKB, inflammation and cytokine storm in COVID-19 3550 7124 5971 PMC8516864__F2 Polyamine pathway and Cadaverine pathway 6723 6611 4942 440 PMC8520212__F5 The tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor? 201633 634 140885 961 3240 PMC8523516__F1 Translational Regulation in Hepatocellular Carcinogenesis 7249 7248 6009 5163 PMC8523946__F3 MiR-873-5p: A Potential Molecular Marker for Cancer Diagnosis and Prognosis 3845 7991 26499 2885 80762 5728 2475 29888 2002 4318 4312 58191 1499 7124 7186 339123 7188 10454 3205 64220 324 2932 PMC8524136__F10 Smoothelin-Like Protein 1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism 219537 6955 1852 3667 PMC8524328__F5 Interferon type I signalling pathway diagram of the COVID‐19 Disease Map integrated with TF activity derived from transcriptomics data after SARS‐CoV‐2 infection 5970 5066 3725 9118 51284 367 10010 9641 2022 PMC8526300__F2 New Horizons for the Roles and Association of APE1/Ref-1 and ABCA1 in Atherosclerosis 348 19 308 84466 51454 301 PMC8526435__F2 Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication 8651 7297 3716 9021 6772 6774 10401 8554 59272 1956 1950 6714 PMC8526962__F4 Everything Old Is New Again: Drug Repurposing Approach for Non-Small Cell Lung Cancer Targeting MAPK Signaling Pathway 100996569 1956 572 842 238 51426 PMC8527034__F7 Astragalus Polysaccharide Reduces Blood Pressure, Renal Damage, and Dysfunction Through the TGFB1-ILK Pathway 4087 4088 3611 PMC8529041__F7 Cancer Cell-Derived Exosomes Promote HCC Tumorigenesis Through Hedgehog Pathway 2735 6469 595 619501 PMC8529123__F2 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA 1019 2295 29843 693184 10776 1063 3169 PMC8531217__F1 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development 3156 6713 4047 PMC8532137__F1 Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology 7421 120227 1593 1436 3553 PMC8533092__F1 Non-Alcoholic Fatty Liver Disease in Lean and Non-Obese Individuals: Current and Future Challenges 6721 80339 53345 1071 90865 3553 5155 PMC8533192__F7 Irradiation Mediates IFNA and CXCL9 Expression in Non-Small Cell Lung Cancer to Stimulate CD8+ T Cells Activity and Migration toward Tumors 3466 2833 115004 3458 4283 3627 3558 3002 5551 PMC8533960__F5 Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer 1101 7450 960 948 961 PMC8534091__F1 Intersection of Purine and Mitochondrial Metabolism in Cancer 5471 353 7808 4522 10606 2806 158 8833 PMC8534485__F1 Porphyrias in the Age of Targeted Therapies 211 212 5498 1371 210 7390 7389 3145 9049 PMC8536203__F10 Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping 10288 933 971 973 2213 930 975 4067 695 118788 7410 29760 2885 5291 5336 5579 27071 207 5879 5530 5894 5604 84433 10892 2932 1147 8517 3551 4772 4793 2353 2638 PMC8536203__F9 Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping 10288 933 971 973 974 8519 930 975 5777 4067 695 6850 7409 2213 29760 118788 2885 5291 6654 5336 5579 27071 3265 25780 5530 5894 1147 8517 3551 84433 10892 3240 2932 5604 4793 2353 2638 PMC8539723__F3 Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis 6774 9021 8651 920 PMC8542577__F3 Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease 5345 5054 666 3818 2160 2157 5340 2158 2159 7450 7056 866 5265 2 2152 7035 PMC8542838__F3 An Integrated View of Deubiquitinating Enzymes Involved in Type I Interferon Signaling, Host Defense and Antiviral Activities 1540 11274 10868 84101 8975 23326 25862 78990 115004 3661 29110 57506 3665 23252 54726 7347 7297 3455 PMC8546001__F4 BMP signaling requirements in mucociliary cell types 4090 4086 4089 PMC8546182__F1 Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease 5027 6389 940 PMC8548342__F5 MinION sequencing from sea ice cryoconites leads to de novo genome reconstruction from metagenomes 2312 5132 6608 5447 PMC8551324__F8 NRIP1 is activated by C-JUN/C-FOS and activates the expression of PGR, ESR1 and CCND1 in luminal A breast cancer 2099 3717 6774 3716 2064 2065 1839 1956 2885 3265 1017 1499 10743 PMC8557683__F6 Circular RNA expression profiles in human bronchial epithelial cells treated with beryllium sulfate 8027 10379 572 10750 PMC85642__F8 Schematic model of cyclin E-associated kinase activity as an integrative convergence point for the regulation of G1/S transition by the “classic” pRb/E2F and the “parallel” Myc-dependent pathways in mammalian cells (thick arrows) 4609 993 1017 PMC8566112__F5 Peroxisomal Beta-oxidation pathway 5825 225 215 51 PMC8569436__F1 STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications 6774 2548 3717 3091 4609 PMC8571891__F1 Oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer 3845 1956 2475 2885 PMC8572812__F3 Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases 3479 3716 3717 2475 6774 PMC8573303__F3 Effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection 958 941 942 1594 6367 PMC8576142__F3 Myeloid dysregulation and therapeutic intervention in COVID-19 4615 6348 6347 PMC8576332__F7 Suppression of EGFR/PKCD/NFKB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer 355 331 8772 1956 1950 4318 PMC8579447__F8 PiRNA-63049 inhibits bone formation through Wnt/Beta-catenin signaling pathway 9049 1499 2932 324 4041 4040 7482 PMC8579454__F3 Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development 948 3579 7124 4615 7099 2534 4067 51135 64429 2194 PMC8582658__F1 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions 4040 4041 1499 324 PMC8582658__F6 Key Role of the WNT/Beta-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions 4040 4041 324 1499 PMC8583315__F1 WNT/Beta-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities? 4040 4041 4919 2932 1499 55366 8549 54894 84133 324 64840 PMC8583315__F3 WNT/Beta-Catenin Pathway in Soft Tissue Sarcomas: New Therapeutic Opportunities? 607 27122 4919 64840 4040 4041 1499 324 2932 54894 84133 55366 8549 PMC8583837__F3 Long Non-Coding RNAs in Endometriosis 1385 378938 6935 100885775 4318 4312 4313 PMC8583909__F1 Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer 1956 1950 2475 6774 PMC8584156__F3 Drosophila melanogaster as a Model Organism to Study Lithium and Boron Bioactivity 474168 1499 3652 PMC8584317__F1 Progress of Signaling Pathways, Stress Pathways and Epigenetics in the Pathogenesis of Skeletal Fluorosis 1499 4040 4041 2932 324 50964 860 PMC8585600__F1 Interleukin-6 in SARS-CoV-2 induced disease: Interactions and therapeutic applications 5447 6774 54106 59272 PMC8586510__F2 Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh 3815 8323 7475 54361 7473 7477 7474 6423 2253 7480 6469 5308 PMC8586683__F6 Chemokine C‐C motif ligand 21 synergized with programmed death‐ligand 1 blockade restrains tumor growth 2932 1236 6366 PMC8589249__F1 CCR7 in Blood Cancers – Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target 6850 695 5336 1236 6363 6366 PMC8589460__F1 Therapeutic strategies targeting Wnt/Beta-catenin signaling for colorectal cancer (Review) 324 1499 2932 4040 4041 4609 PMC8589992__F6 Proposed working model of FATP5-mediated effects on HCC cells 999 1000 2475 619501 PMC8590697__F7 Graphical abstract of the mechanism by which cetuximab enhances RSL3-induced ferroptosis by inhibiting the Nrf2/HO-1 axis through the activation of p38 MAPK 1950 1956 3845 2879 PMC8590789__F6 Cellular retinol binding protein-1 inhibits cancer stemness via upregulating WIF1 to suppress Wnt/Beta-catenin pathway in hepatocellular carcinoma 619501 6657 4072 11197 1499 595 PMC8591697__F2 Targeting regulatory T cells for immunotherapy in melanoma 942 941 3902 9332 PMC8594130__F6 Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm 60674 29110 3661 PMC8598918__F2 Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? 1956 7852 5159 10253 PMC8602684__F2 Metallothionein 1: A New Spotlight on Inflammatory Diseases 6772 6774 4318 PMC8606538__F1 Aberrant Cholesterol Metabolism in Ovarian Cancer: Identification of Novel Therapeutic Targets 3949 6646 6713 2222 6010 19 9619 3156 PMC8606592__F1 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer 7503 283120 100885779 100316868 55000 5820 652995 100124700 171022 378938 643911 347689 728655 60674 55384 101926978 140828 PMC8608597__F9 Super-enhancer-driven lncRNA-DAW promotes liver cancer cell proliferation through activation of Wnt/Beta-catenin pathway 3174 2146 7472 PMC8608878__F6 Schematic presentation of the circKDM4C-regulated pathway in BCa cells 23081 6935 999 1000 PMC8610981__F1 Evaluation of selected IL6/STAT3 pathway molecules and miRNA expression in chronic obstructive pulmonary disease 6774 3572 10401 PMC8611103__F3 Disease-specific interactome alterations via epichaperomics: the case for Alzheimer’s disease 6010 4280 4397 PMC8615493__F6a Mechanical Stretching-Induced Traumatic Brain Injury Is Mediated by the Formation of GSK-3Beta-Tau Complex to Impair Insulin Signaling Transduction 2885 3667 627 PMC8616057__F7 MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells 673 2885 7849 5879 PMC8616064__F2 Mesothelioma Malignancy and the Microenvironment: Molecular Mechanisms 3902 84890 3082 6347 PMC8616335__F5 Cell Cycle Regulation and DNA Damage Response Networks in Diffuse- and Intestinal-Type Gastric Cancer 472 847 4163 PMC8616391__F1 Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It 57817 960 79923 PMC8616433__F4 Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy 3146 717 1956 PMC8617296__F9 Quercetin therapeutic targets for Alzheimer disease and type 2 diabetes mellitus 7422 7124 1956 3725 2002 5595 PMC8618084__F2 Syngas Fermentation for the Production of Bio-Based Polymers: A Review 4548 3045 100187828 PMC8618597__F5 Leucosceptoside A from Devil’s Claw Modulates Psoriasis-like Inflammation via Suppression of the PI3K/AKT Signaling Pathway in Keratinocytes 50616 3605 6347 5743 3240 3717 6772 6364 1673 3569 6278 1672 4288 PMC8619854__F3 Promising Role of TGFB Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report 355 2534 7046 PMC8619966__F1 Hedgehog Pathway Inhibitors against Tumor Microenvironment 3569 56477 3586 3596 3565 3606 51684 6608 PMC8621917__F2 Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention 572 2475 6774 2932 1499 PMC8622245__F1 An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants 7097 4615 7099 7189 PMC8622906__F5 CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes 1436 8205 7054 958 959 PMC8623349__F6 Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis 22937 10682 811 821 596 7186 22926 7494 267 7415 10808 PMC8623999__F7 Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGFB1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction 26291 4087 4088 4318 4313 PMC8624248__F2 Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development 1499 4316 6469 4088 4087 2475 7124 6387 1950 PMC8624906__F2 Transcriptional Regulation of Ripening in Chili Pepper Fruits (Capsicum spp.) 1312 4602 9973 PMC8625973__F5 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy 23558 9113 55841 26524 PMC8625973__F7 Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy 693198 23558 83737 10521 1655 54487 29102 PMC8626953__F1 To explore immune synergistic function of Quercetin in inhibiting breast cancer cells 7454 3717 6772 PMC8630681__F8 Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway 7018 3162 2241 6520 2879 PMC8632454__F2 Recent and Upcoming Drug Therapies for Pediatric Heart Failure 2638 5350 3371 PMC8634046__F7 Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NFKB signaling 7124 10014 3569 PMC8636065__F7 Hippocampal Transcriptome-Wide Association Study Reveals Correlations Between Impaired Glutamatergic Synapse Pathway and Age-Related Hearing Loss in BXD-Recombinant Inbred Mice 85358 2912 2913 54407 2744 2897 2917 2918 2891 2892 2893 196883 5595 2915 PMC8636596__F3 Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway 3661 57506 29110 PMC8638743__F2 Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses 5728 4194 4193 2475 PMC8639500__F4 SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells 9903 3570 1847 1848 6662 3725 3569 3589 1843 2354 6657 4773 56300 11009 1850 596 6772 6774 51561 2353 PMC8640456__F3 An Integrated Analysis Reveals Geniposide Extracted From Gardenia jasminoides J.Ellis Regulates Calcium Signaling Pathway Essential for Influenza A Virus Replication 858 859 613 3270 5350 90550 PMC8642693__F9 Gentiopicroside promotes the osteogenesis of bone mesenchymal stem cells by modulation of B‐catenin‐BMP2 signalling pathway 860 1499 650 4086 4090 PMC8643499__F7 Loss of Zic3 impairs planar cell polarity leading to abnormal left–right signaling, heart defects and neural tube defects 81839 57216 3725 7547 144165 166336 1952 1951 9620 5879 5599 1855 1857 1856 387 22881 23002 PMC8645640__F7 Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway 3717 6774 3569 PMC8645722__F8 G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor 2475 1950 1956 867 2874 PMC8648465__F7 Network Pharmacology-Based Analysis of the Underlying Mechanism of Hyssopus cuspidatus Boriss. for Antiasthma: A Characteristic Medicinal Material in Xinjiang 7124 8717 79866 23118 4599 4149 4351 3725 PMC8648636__F2 Drug combination screening as a translational approach toward an improved drug therapy for chordoma 7039 1950 3082 1956 2475 5728 PMC8649804__F7 Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling 4090 4088 4086 4089 4087 3479 7018 860 PMC8650690__F6 Aronia Upregulates Myogenic Differentiation and Augments Muscle Mass and Function Through Muscle Metabolism 2475 3479 367 4087 PMC8651562__F1 Suppression of InterferonA Treatment Response by Host Negative Factors in Hepatitis B Virus Infection 3455 3454 3661 3665 9636 3716 11274 10379 7297 6772 6773 1956 10581 PMC8652208__F2 Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation 2264 8074 50964 PMC8656686__F2 PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers 23476 84733 7048 7046 56339 10644 2475 7163 619501 8091 7528 10642 PMC8656686__F3 PCAT6 May Be a Whistler and Checkpoint Target for Precision Therapy in Human Cancers 7163 84733 619501 3181 25824 1499 2638 23476 PMC8656925__F1 Targeted Therapy in HR+ HER2− Metastatic Breast Cancer: Current Clinical Trials and Their Implications for CDK4/6 Inhibitor Therapy and beyond Treatment Options 2475 1021 1019 PMC8657018__F1 Promising Antigens for the New Frontier of Targeted Immunotherapy in Multiple Myeloma 8205 952 3716 6774 57823 10320 PMC8657471__F5 EREG/EGFR Pathway in Tumor Progression 673 1956 3845 2069 PMC8657787__F1 Protein Tyrosine Phosphatases: Mechanisms in Cancer 5789 5771 331 6352 PMC8659385__F1 Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses 847 4149 8027 572 8168 PMC8664074__F1 Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma (HCC) initiation and progression 3171 11004 56992 3276 140609 23397 3275 10419 23411 11074 23408 51547 8078 54765 22954 8237 7874 25 221937 139628 8975 57575 51316 54209 3833 64151 54892 4751 9097 3241 8470 51523 50943 7726 135892 81786 619501 PMC8669491__F3 Altered protein secretion in Batten disease 1509 1201 1508 5476 1200 PMC8670088__F4 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis 1283 100506779 105416157 283131 29066 57506 7189 7187 29110 3661 3665 100506668 PMC8671568__F1 Neuroadaptations and TGFB Signaling: Emerging role in models of neuropsychiatric disorders 4090 4086 860 57154 387 92 1960 1499 2903 4209 7046 10486 1627 652 56937 PMC8672419__F4 FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease 7006 100124696 695 126669 PMC8678087__F1 Histone Lysine Methylation and Long Non-Coding RNA: The New Target Players in Skeletal Muscle Cell Regeneration 5077 5081 4617 4656 PMC8687853__F5 H2A.X Phosphorylation in Oxidative Stress and Risk Assessment in Plasma Medicine 596 581 572 637 6741 84126 107966124 790 5480 PMC8696218__F8 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 7048 7046 4087 4088 4089 4092 6615 6935 7291 PMC8696218__F2 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 10683 54567 28514 182 3714 5045 6662 4609 PMC8697442__SF1 Novel targeted co-delivery nanosystem for enhanced ovarian cancer treatment via multidrug resistance reversion and mTOR-mediated signaling pathway 960 2475 581 6774 283871 PMC8699194__F1 Insight into the Double-Edged Role of Ferroptosis in Disease 3309 23657 6520 4015 2879 7157 1803 9817 8031 55847 PMC8699303__F7 Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas 8205 182 54567 PMC8699554__F4 COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and Challenges 338340 2167 54209 2219 6696 7054 2350 3398 6283 3553 3383 962 PMC8700759__F5 C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance 324 941 942 940 920 958 3458 PMC8703376__F2 Inositol Phosphates and Retroviral Assembly: A Cellular Perspective 3706 253430 64768 9562 3705 PMC8704137__F4 Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It 2937 6520 23657 2936 54914 PMC8706716__F1 Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls? 6009 5728 7248 7249 2475 572 5163 PMC8706759__F1 Targeting DNA repair pathway in cancer: Mechanisms and clinical application 8505 6741 5111 472 545 675 11284 7508 PMC8708558__F2 Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression 23406 6624 4046 2275 7791 5228 7431 715 649 5351 80781 4851 145864 10417 84439 221061 4240 871 54863 64236 1292 11173 9260 11117 PMC8714937__F4 LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis 19 2475 3553 PMC8716617__F2 Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells 24145 9780 387 5879 7070 PMC8717717__F2 Transcriptomic analysis of patient plasma reveals circulating miR200c as a potential biomarker for high-grade serous ovarian cancer 5783 27161 4082 5567 1909 5577 5335 29109 5290 7431 5728 51384 7422 PMC8718907__F2 Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology 129807 4758 26503 4759 10825 10020 55907 54187 140838 10559 PMC8719534__F5 Human Metabolites of Hamaforton™ (Hamamelis virginiana L. Extract) Modulates Fibroblast Extracellular Matrix Components in Response to UV-A Irradiation 4312 4320 4323 4318 4313 1893 6678 6696 7057 3371 3672 3685 3690 2335 284217 3908 3909 3693 8516 960 4684 60 PMC8721001__F1 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors 51176 6662 1499 PMC8721001__F2 Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors 51176 5728 6659 1499 960 6662 664613 2475 PMC8724833__F7 Schematic figure of the action of OASL in pulmonary viral infection 196 54106 115004 3661 3665 57506 8638 4615 7189 7098 51284 2625 PMC8734249__F1 CD70-CD27 axis in oncology: the new kids on the block 7186 939 970 PMC8740229__F2 Targeting TREM2 for Parkinson’s Disease: Where to Go? 54209 7099 114548 PMC8741844__F1 CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway 100 4163 619501 PMC8743668__F2 Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma 1024 4040 649446 6774 3717 PMC8744322__F7 Modification of mesenchymal stem cells by HMGB1 promotes the activity of Cav3.2 T-type calcium channel via PKA/Beta-catenin/Gamma-cystathionase pathway 3146 1499 2932 1491 PMC8745114__F1 B Lineage Cells in ANCA-Associated Vasculitis 613 2638 5091 PMC8745152__F9 Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling 2260 8074 84876 PMC8745310__F2 Ubiquitin Signaling in Innate Immune Response by Herpesviruses 6048 23650 79594 10868 84101 1540 3661 115004 29110 8975 81844 22954 90933 91445 57663 PMC8745410__F1 Development and Use of Akt Inhibitors in Prostate Cancer 7249 7248 2475 5728 5163 PMC8745585__F1 Homologous Recombination Deficiencies and Hereditary Tumors 25859 672 79728 675 580 8161 472 5888 545 83990 1017 5890 5892 7517 5889 7516 PMC8745771__F3 Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair 983 7465 5347 PMC8748692__F9 Proposed model for ER-stress-induced AR decrease 1998 468 367 PMC8750045__F1 Tight Control of Non-Canonical TGFB Pathways and MicroRNAs Downregulates Nephronectin in Podocytes 4087 4088 4089 387 9618 7189 2475 6885 PMC8750056__F2 Genetic Mutations of Pancreatic Cancer and Genetically Engineered Mouse Models 2885 1848 5266 5728 PMC8750102__F6 Amino Acid Metabolism in Cancer Drug Resistance 6513 26227 29968 6510 1491 875 8781 11254 619501 PMC8750102__F8 Amino Acid Metabolism in Cancer Drug Resistance 6510 2744 23657 64849 PMC8750192__F1 Osthole Inhibits Expression of Genes Associated with Toll-like Receptor 2 Signaling Pathway in an Organotypic 3D Skin Model of Human Epidermis with Atopic Dermatitis 7096 7100 7097 10333 114609 4118 4615 3654 7189 54106 3553 7124 3576 6347 942 941 7099 51284 7098 PMC8750665__F10 Cherry Polyphenol Extract Ameliorated Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice by Suppressing Wnt/Beta-Catenin Signaling Pathway 1499 324 2932 595 PMC8752351__F3 CD36 in cardiovascular disease 3643 2308 948 PMC8756734__F1 Biological Clock Pathways Are Complex and May Yield Variable Outcomes 2056 2475 23411 PMC8757826__F2 Oral Cancer Stem Cells: Therapeutic Implications and Challenges 5727 100133941 2735 2736 216 6608 4087 648 4088 6657 79923 1499 1956 1950 960 PMC8762210__F11 High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer 80326 245973 529 51606 534 528 127124 90423 523 3845 3480 6009 5728 2475 387 5291 2885 5594 6446 5290 57521 253260 5170 3667 PMC8763273__F4 Upregulation of T Cell Receptor Signaling Pathway Components in Gestational Diabetes Mellitus Patients: Joint Analysis of mRNA and circRNA Expression Profiles 3932 868 7535 4792 3569 7124 175 9775 3383 PMC8766833__F9 Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling 4280 1956 581 PMC8767971__F1 COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway 3162 9817 920 4780 1050 925 5468 3559 3558 2908 3725 2353 23411 2152 5595 1385 7157 5743 2147 2885 462 3439 2157 3667 598 3455 3716 3630 5295 207 54205 596 3456 836 6772 4846 842 11093 213 3827 2597 9622 5340 627 5054 695 7099 4615 51284 5327 4915 4803 10654 3606 3586 3553 3576 3565 6348 6347 4597 4598 6352 4792 3627 5196 9453 2224 3156 3605 1437 7124 2222 3569 6713 4047 7040 3570 4939 1440 4318 4599 9636 4938 7422 2247 PMC8770601__F2 Effect of oxidized lipids of function of myeloid cells in cancer 4353 8205 948 PMC8770806__F2 Applications and Immunological Effects of Quantum Dots on Respiratory System 90865 6347 3569 3553 PMC8773419__F1 DNA Methylation: A Promising Approach in Management of Alzheimer’s Disease and Other Neurodegenerative Disorders 6996 1788 1789 1786 PMC8773620__F1 Molecular Targeted Therapies: Time for a Paradigm Shift in Medulloblastoma Treatment? 51684 6469 6608 PMC8773933__F3 Bcl-2 Family Proteins in Estrogen Receptor-Positive Breast Cancer and Their Implications in Endocrine Therapy 572 638 637 581 317 331 PMC8774728__F1 New Strategies and Combinations to Improve Outcomes in Immunotherapy in Metastatic Non-Small-Cell Lung Cancer 201633 115004 3458 8205 940 941 PMC8775349__F1 Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation 9308 10219 3654 942 3553 2625 50943 4087 4088 929 PMC8776082__F1 Interleukin-24 Immunobiology and Its Roles in Inflammatory Diseases 11009 58985 53833 3716 7297 6278 4582 9021 2312 PMC8777554__F1 Wnt/Beta-catenin signal transduction pathway in prostate cancer and associated drug resistance 23002 387 9475 7481 27130 PMC8781990__F4 Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host 4827 100 100187761 1431 PMC8783100__AF1 Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry 84876 545 472 PMC8789279__F7 Schematics for the BNP-NPRC facilitated signaling pathway and distinct neuropeptide pathways for histamine-dependent and -independent itch 4828 4829 2922 2925 83737 PMC8790521__F2 Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect 2638 50943 8205 84890 1493 920 PMC8799442__F1 Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients 24145 84890 8544 100 952 7226 PMC8801025__F3 Organoids to model the endometrium: implantation and beyond 89780 2255 1950 PMC8801219__F8 Ecballium elaterium attenuates neuroinflammation in an animal model of Alzheimer’s disease through modulation of nuclear factor KB pathway 7124 4615 3553 8717 PMC8802865__F10 Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics 8205 115004 3661 29110 PMC8803618__F3 Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse? 2919 1499 6774 3240 5734 7040 999 PMC8811913__F6 Transition Toward Nitrogen Deprivation in Diatoms Requires Chloroplast Stand-By and Deep Metabolic Reshuffling 2821 7086 9315 PMC8817839__F2 CGRP: A New Endogenous Cell Stemness Maintenance Molecule 6469 7442 362 PMC8820546__F2 AMPK/mTOR Signaling Pathway in Anticancer Activity of Metformin 595 472 581 6009 7248 7249 3479 PMC8824234__F2 Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations 4040 4041 50964 1499 23411 4485 90 860 864 4086 PMC8825381__F1 Progression and metastasis of small cell lung carcinoma: the role of the PI3K/Akt/mTOR pathway and metabolic alterations 435 445 3939 3945 5091 4609 2744 5728 47 PMC8826371__F7 Graphical representation of the possible mechanism by which the stat4 genetic polymorphism affects HCC 6775 7038 10875 1571 PMC8826583__F2 Long Noncoding RNA GAS5: A New Factor Involved in Bone Diseases 283120 57291 100124700 100033819 2303 1499 4092 650 8200 4088 9759 10014 860 PMC8829012__F3 HLA-G: Too Much or Too Little? Role in Cancer and Autoimmune Disease 7535 3135 3805 3570 6774 PMC8829599__F5 Renal calcium and magnesium handling in Gitelman syndrome 7369 10399 54822 140803 54805 PMC8833906__F1 Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia 6713 3156 1718 3638 22937 255738 PMC8834318__F4 Cisplatin Resistance in HPV Negative Head and Neck Squamous Cell Carcinomas 3688 4015 1301 8205 PMC8835847__F8 microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells 7852 960 100133941 999 6935 1499 PMC8835893__F1 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance 6469 50846 3549 6608 51684 PMC8835893__F2 Hedgehog Pathway Inhibitors as Targeted Cancer Therapy and Strategies to Overcome Drug Resistance 2475 4088 8650 387 6608 5879 6714 PMC8836457__F1 Sclerostin in Bone Diseases 4040 4041 1499 PMC8836889__F2 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review 355 8772 637 PMC8836889__F5 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review 596 581 5728 PMC8836921__F1 IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment 3976 3569 3977 5008 9180 3589 PMC8838558__F7 One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue 4524 635 875 4548 PMC8843894__F2 Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants 1401 3553 114548 PMC8843930__F1 Toward a Better Classification System for NK-LGL Disorders 3570 355 2475 6774 54790 4609 6347 PMC8844036__F8 Schematic diagram of sEVs DNAJB8 based signaling pathway in CRC L-OHP resistance 7157 165721 283871 PMC8847181__F2 Functional and Therapeutic Significance of Tumor-Associated Macrophages in Colorectal Cancer 10979 6774 94234 3717 7124 3576 7042 2475 5970 3718 PMC8847224__F2 Dissecting the Crosstalk Between Nrf2 and NFKB Response Pathways in Drug-Induced Toxicity 7124 5970 4055 5971 PMC8848739__F4 Case report of recurrent fibromatosis with laryngeal involvement: Treatment based on network analyses of NGS data 221061 1438 80128 150696 3739 4921 4193 10928 7157 1995 10156 4145 11081 780 11140 4919 4593 2241 132160 PMC8848980__F6 Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus 147183 112802 3229 8456 1747 8643 5727 2304 51176 11211 341640 158326 80144 1277 1293 7059 4067 695 6423 147111 5294 959 4050 7409 5880 PMC8851069__F3 Advances in cGAS-STING Signaling Pathway and Diseases 115004 114548 3661 PMC8851069__F4 Advances in cGAS-STING Signaling Pathway and Diseases 7019 581 115004 PMC8857760__F3 Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights 355 637 581 317 PMC8860543__F8 TNFA Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells 3717 6774 2308 7018 PMC8861859__F7 Wheat oligopeptides enhance the intestinal mucosal barrier and alleviate inflammation via the TLR4/Myd88/MAPK signaling pathway in aged mice 4280 7099 4615 3553 3383 847 PMC8863324__F1 Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives 1674 5066 324 PMC8866335__F2 Small, Dense Low-Density Lipoprotein-Cholesterol and Atherosclerosis: Relationship and Therapeutic Strategies 387 6010 1582 3949 467 7220 7222 581 PMC8866648__F2 Vascular Stem/Progenitor Cells in Vessel Injury and Repair 22926 4040 4041 27122 1499 595 406989 PMC8867251__F7 Inhibition of the VEGF signaling pathway attenuates tumor-associated macrophage activity in liver cancer 619501 8205 2475 PMC8868096__F2 Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia 2810 3162 1728 9817 PMC8869630__F1 Small Hero with Great Powers: Vaccinia Virus E3 Protein and Evasion of the Type I IFN Response 115004 29110 7189 57506 3661 3665 7187 197259 11035 81030 7297 3454 3455 3716 6772 6773 6041 10379 PMC8872267__F1 Therapeutic Metabolic Reprograming Using microRNAs: From Cancer to HIV Infection 406935 3091 3939 PMC8873175__F1 Therapeutic Potential of Glutamine Pathway in Lung Cancer 10365 11051 10991 2744 1723 PMC8875868__F5 Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance 5728 9531 2539 10298 472 PMC8875960__F1 Druggable Molecular Pathways in Chronic Lymphocytic Leukemia 613 973 4067 695 5336 7018 PMC8876671__F3 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance 57167 4854 4211 6657 28514 23493 3280 9794 PMC8877534__F9 Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/Beta-Catenin Signaling Pathway 1499 4040 4041 2932 1019 PMC8880424__F6 Multi-Omic Analysis to Characterize Metabolic Adaptation of the E. coli Lipidome in Response to Environmental Stress 283871 5662 735 PMC8882273__F7 Selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease 114548 3064 3553 PMC8882844__F2 Mitochondrial DNA Depletion Syndrome and Its Associated Cardiac Disease 7084 8802 8801 PMC8883943__F1 D-Amino Acids as a Biomarker in Schizophrenia 1610 8528 267012 PMC8889574__F1 Impact of High Dose Glucocorticoids on Bone Health and Fracture Risk in Systemic Vasculitides 4353 3569 860 22943 1493 PMC8889706__F8 LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation 3949 64241 64240 PMC8891295__F1 Opposing transcriptional programs ensure cholesterol homeostasis in macrophages 9619 19 3949 PMC8891573__F1 Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction—Molecular Mechanisms and Clinical Significance 23576 23564 64902 PMC8892088__F1 Metabolic regulation of ferroptosis in the tumor microenvironment 23657 6520 2879 PMC8892088__F5 Metabolic regulation of ferroptosis in the tumor microenvironment 948 2879 340061 177 PMC8894463__F8 Schematic illustrating the mechanism by which TRIM45 regulates cerebral I/R injury by activating NFKB signaling in microglia 23118 80263 10454 PMC8895153__F3 SUMOylation in Viral Replication and Antiviral Defense 57506 29110 3661 3665 10475 10210 10155 10401 59343 29843 PMC8899182__F2 Regulation of PBXs and their emerging role in cancer 4854 5087 5089 5090 8239 79923 3717 6774 PMC8899859__F10 Obstructive Sleep Apnea Affects Lacrimal Gland Function 3091 5465 355 920 948 PMC8901678__F2 Systemic iron homeostasis 154214 2056 23516 PMC8901705__F1 Key therapeutic targets in the pathogenesis of autoimmune diseases 930 952 2638 3716 3717 3718 7297 7124 3553 50615 324 942 958 941 149233 29851 940 1493 PMC8902310__F3 Type I Interferon Responses to Influence Tumor-Immune Cross Talk in PDAC 29110 7187 7098 3661 115004 57506 6780 5167 PMC8904414__F1 Different Pattern of Cardiovascular Impairment in Methylmalonic Acidaemia Subtypes 867 868 23624 PMC8905338__F5 Personalized Management of Pheochromocytoma and Paraganglioma 1956 2260 5979 10461 55654 4763 4149 3065 6752 PMC8905584__F10 To detect potential pathways and target genes in infantile Pompe patients using computational analysis 161497 324 2241 5829 867 6809 PMC8905633__F4 Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation 3356 5724 5029 3579 1129 1128 3558 7852 1234 10800 151 134 1131 729230 186 140 2908 6714 2597 6774 598 5290 5599 5595 1432 836 351 3725 7124 5594 PMC8905735__F9 Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis 4087 10213 7046 PMC8906930__F4 NRF2 in Bone Metabolism – Friend or Foe? 9935 4609 7189 4772 799 100187907 1513 81501 6002 PMC8906956__F8 Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO-1 Signal Axis 6520 23657 2879 PMC8909150__F1 Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia 867 2885 9846 3845 4763 PMC8913526__F1 Helminth and Host Crosstalk: New Insight Into Treatment of Obesity and Its Associated Metabolic Syndromes 3553 7124 847 PMC8914022__F1 Weighing in on Adipogenesis 23409 3712 56922 2744 PMC8915145__F3 Common pathways control autoimmune susceptibility and TFH cell homeostasis 1493 7054 940 643 29851 5771 987 PMC8915851__F1 Of NRF2 Pathway in Preventing Developmental and Reproductive Toxicity of Fine Particles 4094 1728 9817 PMC8920547__F4 Clinical Characteristics of Patients With IgG4-Related Disease Complicated by Hypocomplementemia 920 27202 57823 717 730 729 735 PMC8921539__F4 Hypoxia and chronic kidney disease 1956 7428 9817 2056 2057 PMC8921770__F9 Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis 4772 1513 4318 81501 54 PMC8924142__F2 Type I interferon-mediated tumor immunity and its role in immunotherapy 3146 7099 283420 54106 7098 4615 115004 81030 51428 3665 6573 81622 148022 29110 3661 3663 PMC8924518__F3 Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora 8800 26291 5465 1374 4015 PMC8927572__F2 Components of the MAPK pathway are mutated in both HNSCC (at somatic level) and in various RASopathies at germline level 4763 161742 2885 1845 1849 1848 1852 1847 PMC8928136__F5 Signaling pathways by DJ-1: An updated overview 839 1843 23411 581 PMC8930976__F2 Queueing theory model of pentose phosphate pathway 2539 25796 6120 5226 PMC8932121__F4 Inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD 115004 3661 29110 7124 10133 203228 PMC8934501__SF1 GSK-3B suppression upregulates Gli1 to alleviate osteogenesis inhibition in titanium nanoparticle-induced osteolysis 6608 4280 2735 860 PMC8934553__F7 LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway 3950 2475 1003 PMC8935239__F9 Icariside II enhances cisplatin-induced apoptosis by promoting endoplasmic reticulum stress signalling in non-small cell lung cancer cells 83939 468 22926 PMC8939789__F7 Integrated model of potential mechanisms of HIV transcription and latency modulation by Beta-catenin 920 1499 246751 PMC8943788__F6 rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori–infected individuals: a genome-wide association study in the Korean population 5245 8405 22834 2638 PMC8944161__F1 Clinical benefits of PD-1/PD-L1 inhibitors in patients with metastatic colorectal cancer: a systematic review and meta-analysis 324 941 940 3932 7535 27040 3558 PMC8945550__F1 Cutting-Edge Therapies and Novel Strategies for Acute Intermittent Porphyria: Step-by-Step towards the Solution 9049 210 3145 PMC8946298__F3 Cross-Talk between p53 and Wnt Signaling in Cancer 324 6925 1499 8312 PMC8948419__F5 Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans 5163 208 207 PMC8957809__F8 Nobiletin Induces Ferroptosis in Human Skin Melanoma Cells Through the GSK3Beta-Mediated Keap1/Nrf2/HO-1 Signalling Pathway 2932 9817 2879 PMC8957861__F1 How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment 1401 1356 718 5340 7018 PMC8959827__F8 PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis 1506 5166 5132 3156 PMC8959898__F1 Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients – a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown 7099 7124 1101 3569 5465 26291 3586 929 2475 PMC8966724__F2 Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury 114548 581 115004 54106 3661 29110 PMC8968907__F4 Mitochondrial anti-apoptotic dependencies of hematologic malignancies: from disease biology to advances in precision medicine 6387 960 7852 958 581 3845 596 4170 5781 PMC8969174__F1 Genetic architecture of childhood BMI exhibits dynamic changes over early childhood 10019 57018 26086 2645 1742 2099 3953 5122 831 2740 2494 64399 90025 4988 51085 136259 5727 254102 9612 6457 54453 3952 254251 3174 51196 7356 388795 4160 89866 23017 79068 181 4852 5697 PMC8975241__F1 Effect of PD-1 on T cell-mediated signaling pathways and metabolism 324 7535 3932 2534 4772 940 2475 355 1374 4088 PMC8975741__F8 The role of TSPAN6 in the regulation of signaling pathways in tumorigenesis 23513 1956 7105 PMC8978522__F6 RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4‐TRIF pathway 3661 7099 10210 7187 6774 PMC8978634__F6 Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome 114548 140609 3553 79792 PMC8979166__F2 Why Does Piscirickettsia salmonis Break the Immunological Paradigm in Farmed Salmon? Biological Context to Understand the Relative Control of Piscirickettsiosis 735 3577 4345 324 6775 920 933 951 PMC8979819__F8 Schematic summarizing the effects of Gab2 on RTK expression and signaling in Flt3-ITD positive AML 9846 558 2675 5979 PMC8980962__F5 JAK/STAT: Why choose a classical or an alternative pathway when you can have both? 6774 3718 2056 3560 PMC8984481__F1 Escaping Death: How Cancer Cells and Infected Cells Resist Cell-Mediated Cytotoxicity 637 581 8772 841 197259 11035 8737 8717 7186 7124 81858 355 PMC8987592__F1 TGFB/Smad Signaling Pathway in Tubulointerstitial Fibrosis 7939 4087 4088 4092 4089 PMC8989389__F1 Malignant glioma subset from actuate 1801: Phase I/II study of 9-ING-41, GSK-3B inhibitor, monotherapy or combined with chemotherapy for refractory malignancies 2932 596 331 PMC8989557__F1 Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy 920 958 940 355 PMC8990295__F3 Cancer metabolism challenges genomic instability and clonal evolution as therapeutic targets 51548 23410 7523 3091 2879 23657 PMC8990718__F6 Serum amyloid A 1 induces suppressive neutrophils through the Toll‐like receptor 2–mediated signaling pathway to promote progression of breast cancer 6288 7097 4615 PMC8995529__F1 Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway 5925 5111 1027 4846 1544 836 1557 1559 330 331 329 1026 1029 1019 207 1543 1021 595 1017 PMC8996962__F2 Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer 8717 7186 958 7187 PMC8996985__F3 Transforming Growth Factor-Beta Orchestrates Tumour and Bystander Cells in B-Cell Non-Hodgkin Lymphoma 4087 4088 4091 4092 4089 4086 4090 PMC8998406__F1 Notch Signaling Pathway by Bioactive Dietary Agents 4851 102 100188776 595 79923 6662 PMC8998804__F1 Transcription Factors with Targeting Potential in Gliomas 7018 1956 6608 2305 140821 6774 5447 PMC8998982__F2 Cyclin-Dependent Kinase Synthetic Lethality Partners in DNA Damage Response 4149 4609 1956 23476 51755 1025 6790 9212 5347 3099 226 6509 5163 10055 23481 293 6520 5198 790 545 468 4170 PMC8999556__F4 New Perspectives in Treating Acute Myeloid Leukemia: Driving towards a Patient-Tailored Strategy 2322 7263 3815 PMC9001073__F6 Isoflurane Attenuates Cerebral Ischaemia–Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice 114548 4615 7099 3553 PMC9001082__F3 PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress 4087 4088 2475 50507 PMC9006445__F1 Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies 8717 8772 7186 355 581 6774 PMC9006951__F1 Alzheimer’s Disease: An Update and Insights Into Pathophysiology 2885 2252 2263 PMC9008778__F4 Thrombosis and Inflammation—A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C 7018 114548 3606 5196 5091 7450 PMC9014844__F3 Using Intermittent Fasting as a Non-pharmacological Strategy to Alleviate Obesity-Induced Hypothalamic Molecular Pathway Disruption 4852 181 3458 PMC9016198__F1 Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early Anticoagulation 59272 7113 7018 PMC9019265__F1 Statins and endocrine resistance in breast cancer 8205 2475 5874 6010 PMC9020229__F3 Endocrine Regulation on Bone by Thyroid 3480 3479 1499 650 PMC9025382__F6 RNA-Seq of Cyst Nematode Infestation of Potato (Solanum tuberosum L.): A Comparative Transcriptome Analysis of Resistant and Susceptible Cultivars 2241 2077 4602 PMC9027032__F9 Differential Nanoscale Topography Dedicates Osteocyte-Manipulated Osteogenesis via Regulation of the TGFB Signaling Pathway 2033 2335 1277 860 PMC9027240__F3 Target Therapy for Hepatocellular Carcinoma: Beyond Receptor Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors 1499 2932 324 4040 4041 3952 PMC9027306__F2 MST1R/RON Tyrosine Kinase in Cancer: Oncogenic Functions and Therapeutic Strategies 1499 768 2932 6495 2885 3939 3099 PMC9029304__F1 Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications 595 2475 7248 7249 3667 PMC9031072__F2 Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use 2056 3717 2057 PMC9031703__F6 Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/Beta-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response 10866 2885 3667 6009 2932 7249 7248 2475 5141 100302522 5728 PMC9032397__F1 Vitamin D and Ocular Diseases: A Systematic Review 4827 120227 1593 1628 1594 1591 PMC9032796__F3 Epitranscriptomics of SARS-CoV-2 Infection 3661 56339 23269 3725 6773 PMC9033023__F1 HSP90 mediates IFNGamma-induced adaptive immune resistance in pancreatic cancer 3459 3458 3716 3717 6772 3460 10098 PMC9033766__F6 Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways 860 1277 7124 PMC9035706__F1 Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling 6472 5471 10797 25902 6470 2618 4522 5198 7808 10606 158 PMC9038189__F5 Cyst lineage recovery after ablation 5728 1956 1950 PMC9040077__F1 Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease 355 8772 8717 637 3458 PMC9043318__F2 miRNAs Can Affect Intestinal Epithelial Barrier in Inflammatory Bowel Disease 3553 4615 7099 PMC9044593__F8 An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer 10919 4800 217 PMC9046545__F4 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review 2260 2263 2261 2264 PMC9047385__F1 Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease 3929 929 7099 4615 51135 7189 PMC9048116__F7 Autotaxin signaling facilitates B cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency 23410 5168 4018 PMC9056228__F2 Research Progress of Ferroptosis in Adiposity-Based Chronic Disease (ABCD) 1719 3652 1723 2879 PMC9065265__F5 SLC7A11, a Potential Therapeutic Target Through Induced Ferroptosis in Colon Adenocarcinoma 2730 2729 2879 960 6520 6506 6519 PMC9068921__F7 Mechanism graph of the regulatory role of circ_0000811 in cerebral ischemic vertigo 5576 6772 3717 PMC9070300__F2 Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer’s Disease: Possible Therapeutic Role of KV1.3 Channel Blockade 114548 7099 2534 3553 PMC9074275__F6 Tetraspanin 7 promotes osteosarcoma cell invasion and metastasis by inducing EMT and activating the FAK-Src-Ras-ERK1/2 signaling pathway 2335 1000 7102 6714 PMC9074313__F3 Functional roles of the circRNA/Wnt axis in cancer 1499 27123 2487 PMC9074313__F5 Functional roles of the circRNA/Wnt axis in cancer 22943 1499 83737 PMC9083113__F8 Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease 351 4087 4088 PMC9083130__F7 Integrin A4 up-regulation activates the hedgehog pathway to promote arsenic and benzopyrene co-exposure-induced cancer stem cell-like property and tumorigenesis 3676 51684 2735 PMC9083465__F11 Integrating Lipidomics and Transcriptomics Reveals the Crosstalk Between Oxidative Stress and Neuroinflammation in Central Nervous System Demyelination 7038 5091 1535 PMC9084694__F4 Single‐cell profiling of transcriptomic changes during in vitro maturation of human oocytes 113457 7278 7306 134285 57458 7982 51703 83759 967 257106 4622 6597 1026 9227 3601 3399 1032 140578 2950 1848 2048 2263 4553 PMC9085228__F3 miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer 7454 4117 238 2475 8833 7054 81610 PMC9085754__F4 MALAT1 as master regulator of biomarkers predictive of pan-cancer multi-drug resistance in the context of recalcitrant NRAS signaling pathway identified using systems-oriented approach 2625 399717 2297 6934 4087 7022 6678 2353 283120 647979 1869 861 2335 100124700 100507428 5970 4790 1958 399959 3091 4774 6667 3727 104355217 101805488 90632 4088 441355 3726 1050 378938 960 PMC9086235__F1 Interaction Between Autophagy and JAK/STAT3 Signaling Pathway in Tumors 3717 3718 3716 59067 7297 3458 PMC9086835__F7 LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis 3939 2475 6426 PMC9090832__F7 Olig2-Ddx20 axis-mediated suppression of p53 pathway 50628 11218 8487 54960 79833 79760 10215 25929 4193 PMC9091111__F5 Curcumin treats endometriosis in mice by the HIF signaling pathway 355 3725 5468 2932 836 7422 1950 4790 367 7157 2353 PMC9097379__F7 ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells 387 3553 3146 6850 3654 4615 PMC9097893__F2 NLRX1 Deficiency Alters the Gut Microbiome and Is Further Exacerbated by Adherence to a Gluten-Free Diet 7124 7054 22861 199713 90865 6761 7186 7187 79671 5971 6387 PMC9098154__F6 Schematic explaining the role of LINC00926 in orchestrating the regulation of WNT10B in order to regulate IFNG expression 7480 283663 3458 PMC9098816__F2 Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death 7124 3146 4615 PMC9099213__F1 “Self-Sacrifice” of ImmuneCells in Sepsis 619537 58484 197358 79792 PMC9100033__F1 Disorders of the Calcium Sensing Signaling Pathway: From Familial Hypocalciuric Hypercalcemia (FHH) to Life Threatening Conditions in Infancy 1175 846 51083 PMC9103444__F8 Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer 652995 693198 51755 60674 PMC9105177__F2 Roles of Ubiquitination in Pathogenesis of Influenza Virus Infection 7706 1283 57506 29110 3661 PMC9105255__F6 Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia 6476 55364 367 56955 PMC9105721__F1 Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity 4889 3953 4852 181 5122 5126 5443 4159 4160 PMC9106028__F1 Front-Line Therapy for Metastatic Renal Cell Carcinoma: A Perspective on the Current Algorithm and Future Directions 2475 558 1493 324 PMC9110840__F1 Advances in the Study of the Ubiquitin-Editing Enzyme A20 3553 4615 7189 8887 7553 8717 7186 7188 7124 PMC9113573__F6 Proposed mechanism by which proHp inhibits the TGF-Beta-induced EMT in SK-Hep1 liver cancer cells 4090 4086 4087 4088 1000 PMC9113786__F1 Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities 5443 6774 3953 PMC9117271__F1 Apoptotic signaling in VC 27429 581 355 8772 331 7124 6395 6093 PMC9120647__AF1 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo 558 6714 2475 2932 595 PMC9124765__F2 Biomechanical Regulatory Factors and Therapeutic Targets in Keloid Fibrosis 387 4092 4087 4088 4089 PMC9127157__F4 Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer 317 100188953 4837 9547 6774 9021 7189 9242 8205 PMC9127157__F5 Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer 1499 3458 100124700 3204 672 PMC9128178__F7 Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer 2064 65061 207 4609 595 1021 1019 2099 8621 PMC9130392__F1 mTOR pathway gene expression in association with race and clinicopathological characteristics in Black and White breast cancer patients 7249 7248 6009 PMC9130470__F3 NTRK Fusions in a Sarcomas Series: Pathology, Molecular and Clinical Aspects 2885 5728 5163 PMC9131376__F4 Recent Progress in the Development of Novel Mycobacterium Cell Wall Inhibitor to Combat Drug-Resistant Tuberculosis 355 3623 4322 PMC9131939__F14 Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach 6009 581 3091 6774 5728 545 472 PMC9135563__F5 Comprehensive Diagnostic Medical System Based on Notch1 Signaling Pathway to Inhibit the Growth of Small-Cell Lung Carcinoma 351 6611 7808 PMC9138861__F7 Targeting TKI-Activated NFKB2-MIF/CXCLs-CXCR2 Signaling Pathways in FLT3 Mutated Acute Myeloid Leukemia Reduced Blast Viability 2919 6374 3576 3579 1019 4282 4791 960 972 2322 PMC9138898__F1 Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity 841 637 836 581 842 331 PMC9139203__F1 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer 672 4361 10111 472 79728 5888 675 PMC9139203__F8 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer 672 472 79728 675 5888 PMC9139286__F4 DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease 1654 8772 841 114548 56919 1660 PMC9139317__F5 Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma 169355 3620 125061 8942 8564 PMC9139376__F6 Three-Dimensional Organotypic Cultures Reshape the microRNAs Transcriptional Program in Breast Cancer Cells 2475 3709 4089 5599 7249 51719 5728 6093 4087 5214 1316 6774 4214 5601 5747 4170 7048 7436 230 1387 27250 9590 5663 3588 27122 226 5534 1027 1026 331 4853 10664 7027 650 100302276 894 5594 5781 8065 4313 595 983 1019 5933 10146 1736 1950 6790 8317 6574 1871 1869 23612 4814 100302142 5218 65061 9221 339416 1432 6513 990 64065 58476 256356 1021 4084 6500 9612 100423023 8851 7039 4193 441478 1278 9180 26207 659 3554 6667 85301 1303 5817 9241 4091 64750 3065 1033 2619 4638 5352 4090 1284 57154 84823 6304 1282 PMC9139943__F6 Clinical Landscape of PARP Inhibitors in Ovarian Cancer: Molecular Mechanisms and Clues to Overcome Resistance 6741 91607 8505 79728 PMC9141700__F3 Metabolite and Gene Expression Analysis Underlying Temporal and Spatial Accumulation of Pentacyclic Triterpenoids in Jujube 4598 4597 3652 PMC9144176__F1 Targeting Membrane Trafficking as a Strategy for Cancer Treatment 1499 595 2932 6935 4286 PMC9144507__F2 Metformin and Cancer, an Ambiguanidous Relationship 7249 2475 3479 3480 PMC9144962__F1 Extracellular Vesicles—A New Potential Player in the Immunology of Renal Cell Carcinoma 768 406992 3135 6774 355 841 836 970 939 4087 4088 4089 PMC9146539__F1 Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease 302 5868 4905 6622 1813 PMC9146657__F5 Integrated Transcriptomics and Nontargeted Metabolomics Analysis Reveal Key Metabolic Pathways in Ganoderma lucidum in Response to Ethylene 2224 6389 4967 84680 PMC9157498__F2 Noncanonical PD-1/PD-L1 Axis in Relation to the Efficacy of Anti-PD Therapy 1977 6772 6778 958 941 942 PMC9157711__F2 Hepatitis B virus in development of hepatocellular carcinoma: Focus on covalently closed circular DNA 359806 5111 2146 728655 619501 8847 3169 55167 54567 6774 4851 27350 9582 PMC9158144__F7 Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer 4502 4485 26524 PMC9161009__F8 The unique telomere protection mechanism in ES cells 472 545 6046 201516 9656 PMC9162579__F4 Genome-Wide Mutant Screening in Yeast Reveals that the Cell Wall is a First Shield to Discriminate Light From Heavy Lanthanides 11043 10195 29929 PMC9162805__F3 IKKE in the Metabolic Diseases: Physiology, Pathophysiology, and Pharmacology 10010 3665 3661 5140 PMC9163413__F8 Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model 4615 7099 7189 3553 PMC9163742__F3 Prospective Application of Melatonin in Treating Epigenetic Dysfunctional Diseases 7045 4088 196528 PMC9165361__F1 Implication of 14-3-3ζ-BDNF pathway in long-lasting memory enhancement and the rescue from memory deficits 627 10636 10399 PMC9168746__F1 Starch metabolism in potato photosynthesizing (leaves) and storage (tubers) organs 2695 1356 3064 PMC9170957__F2 From Therapy Resistance to Targeted Therapies in Prostate Cancer 367 7018 1956 6714 PMC9171628__F2 Rational Use of Complement Inhibitors in Kidney Diseases 718 10747 721 6955 PMC9171887__F1 SARS-CoV2 and mitochondria: the impact on cell fate 1386 596 4170 PMC9177660__F2 NcRNAs implicated in regulation of ferroptosis 2879 23657 121549 283131 145249 326343 729082 PMC9178120__F5 Contribution of the Tumor Microenvironment to Metabolic Changes Triggering Resistance of Multiple Myeloma to Proteasome Inhibitors 7415 367 26227 23657 PMC9179338__F3 Small but Powerful: The Human Vault RNAs as Multifaceted Modulators of Pro-Survival Characteristics and Tumorigenesis 7942 56664 8878 PMC9179486__F3 Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated 3397 125061 8564 8942 619501 PMC9179504__F1 Small Extracellular Vesicles: Key Forces Mediating the Development and Metastasis of Colorectal Cancer 3845 2762 6280 5728 6774 10563 7852 PMC9180633__F1 Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma 102 6868 3516 3280 23462 441478 PMC9181451__F1 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases 10320 51185 1642 PMC9181451__F3 Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein–Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases 9584 55147 90379 PMC9183236__F9 Regulating alveolar formation through mitochondrial activity and distribution 7019 55288 5154 5156 23531 PMC9188247__F8 Intramyocardial injected human umbilical cord-derived mesenchymal stem cells (HucMSCs) contribute to the recovery of cardiac function and the migration of CD4+ T cells into the infarcted heart via CCL5/CCR5 signaling 920 6347 729230 6352 1234 PMC9195630__F10 Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143 3099 100128191 4323 4312 PMC9198352__F2 Strategies of LncRNA DLX6-AS1 on Study and Therapeutics 2521 11184 1749 1750 2475 285987 PMC9199383__F2 Neutrophils in COVID-19: Not Innocent Bystanders 3455 3454 7297 3716 6772 6773 10379 114548 55183 29110 3661 115004 59272 4615 51311 54106 51284 7189 7187 PMC9199556__F6 Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States 4353 5730 51393 PMC9201061__F2 Clinical Manifestations and Molecular Backgrounds of Parkinson's Disease Regarding Genes Identified From Familial and Population Studies 120892 6622 54832 PMC9203716__F3 Case Report: Extensive Tumor Profiling in Primary Neuroendocrine Breast Cancer Cases as a Role Model for Personalized Treatment in Rare and Aggressive Cancer Types 5728 6446 6794 11201 596 10682 PMC9204157__F2 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis 7939 5340 387 2475 10716 PMC9204157__F4 Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis 1956 4092 4087 4088 4089 80122 6714 7852 6387 PMC9206138__F2 Immunosuppressive role of indoleamine 2, 3-dioxygenase in glioblastoma: mechanism of action and immunotherapeutic strategies 920 7054 100187761 PMC9206264__F1 Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness 11200 5888 580 83990 672 675 PMC9208136__F1 Optimizing the downstream MVA pathway using a combination optimization strategy to increase lycopene yield in Escherichia coli 4598 4597 3652 PMC9216203__F1 Secreted proteins positively related to bone homeostasis and baseline Vo2max 64093 9241 1893 1833 1297 1311 55118 PMC9217541__F7 Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking 4397 5241 9961 6932 3659 1281 6401 5468 PMC9220225__F2 2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies 64798 9682 7428 PMC9221178__F5 Microbial-Derived Toll-like Receptor Agonism in Cancer Treatment and Progression 7099 7187 29110 3661 7098 PMC9221615__F9 Endothelial Dysfunction in Acute Hepatic Porphyrias 210 3145 7389 7390 1371 5498 2235 875 PMC9223434__F7 Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets 10379 6773 6772 3454 3455 3659 6890 PMC9224267__F2 EGFR-Mutated Non-Small Cell Lung Cancer and Resistance to Immunotherapy: Role of the Tumor Microenvironment 8205 6774 1956 PMC9225892__F8 Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NFKB Pathways 7408 4827 1513 100187907 PMC9228804__F6 Tumor Suppressive Effects of GAS5 in Cancer Cells 60674 5728 1977 7249 7248 6009 2475 1975 PMC9232097__F7 Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer 367 3791 1513 3815 6714 3932 5602 1017 7048 5770 6009 5468 3718 5241 3558 1457 3717 3098 2260 6648 1969 1509 890 5170 6850 4846 5467 1432 5347 2100 3265 2099 5328 3320 4843 3312 5594 2932 1612 207 2950 208 4312 836 331 6256 5599 3480 1956 7046 5743 387 PMC9232692__F2 Emerging roles of spliceosome in cancer and immunity 11338 7536 7307 PMC9233184__F1 Complex relationship between integrins and oncolytic herpes Simplex Virus 1 in high-grade glioma therapeutics 3491 3611 1499 6774 200424 145258 7040 1956 6714 3091 PMC9233553__F2 Coronaviral PLpro proteases and the immunomodulatory roles of conjugated versus free Interferon Stimulated Gene product-15 (ISG15) 2813 7297 11274 9636 3458 PMC9234708__F3 Biomineralization associated alkaline phosphatase as a potential marker of bone metastasis in the patients with invasive breast cancer 248 251 249 51752 206338 1300 847 2028 56246 5468 112609 337 2352 860 79802 861 864 2643 650 947 2822 PMC9235271__F5 Metabolomics profile in acute respiratory distress syndrome by nuclear magnetic resonance spectroscopy in patients with community-acquired pneumonia 11113 51199 213 1401 920 PMC9235413__F5 Site of action of the Wnt signaling pathway inhibitors that are in current or were in past clinical trials 2932 324 1499 4041 64840 PMC9237231__F4 Regulation and Modification of GSDMD Signaling in Diseases 6737 79792 4814 8011 8737 8772 PMC9237249__F2 COVID-19 Causing ARDS: Exploring the Possibility of Preventing and Treating SARS-CoV-2 355 59272 7124 PMC9237599__F7 Exosomes-mediated tumor treatment: One body plays multiple roles 4087 4088 572 581 PMC9240045__F7 Schematic time-course changes in cellular processes in phosphorylase liver isoform knockdown (shPYGL) and control (shControl) U87MG glioblastoma (GBM) cells following high dose ionising radiation (IR) 5837 5834 5836 2548 2997 2632 PMC9240865__F3 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease 4018 22937 79143 5979 619501 PMC9241034__F6 Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSA facilitates processing of oxidative DNA damage in human cells 6418 472 29072 PMC9247101__F5 Targeting fibrosis: mechanisms and clinical trials 1950 4092 4087 4088 4089 7939 7048 7046 PMC9247520__F2 Cryptic Phosphorylation-Mediated Divergent Biosynthesis of High-Carbon Sugar Nucleoside Antifungals 7851 5429 51426 11201 PMC9247880__F2 Molecular Genetics and Targeted Therapies for Paediatric High-grade Glioma 5156 2064 1021 1019 1956 4763 673 4609 1017 4193 7249 7248 2475 4194 5728 PMC9248037__F3 Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer 3172 6783 2932 PMC9248407__F3 Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors 22863 161 7054 4311 2096 6418 1628 24 5979 PMC9250978__F2 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways 1636 3661 29110 57506 3665 PMC9252100__F6 Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFA/NFKB Pathway 9173 7187 7124 PMC9252714__F9 Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death 338340 355 8772 581 PMC9252752__F7 Inhalation of Salvianolic Acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway 847 7099 4615 7189 114548 3603 PMC9253674__F7 Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1B Pathway by Nrf2 Signaling Activation 9817 4094 2729 2730 114548 3553 79792 PMC9255244__F3 Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response 406921 7099 4615 330 10533 100616274 4775 7474 1675 PMC9255545__F1 Drug targets in the IL-23–IL-17 pathway 3458 23765 84818 PMC9259561__F4 PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway 3674 4353 10319 3690 2814 158326 131873 7010 9223 5649 256076 5617 2255 1511 183 551 9002 10874 5327 1991 1950 2885 5352 3667 5196 7450 5728 PMC9260022__F4 ILP-2: A New Bane and Therapeutic Target for Human Cancers 598 995 2475 PMC9260738__F1 Hypoxia-inducible factor-1A: A critical target for inhibiting the metastasis of hepatocellular carcinoma 8205 28996 7052 7428 3091 619501 PMC9260869__F6 Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells 7186 6101 7124 8717 PMC9261164__F2 Pleiotropic effects of cell competition between normal and transformed cells in mammalian cancers 11025 6010 9294 7431 5166 1969 27299 PMC9262551__F3 Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets 2475 114548 10628 PMC9263829__F1 Can the cGAS-STING Pathway Play a Role in the Dry Eye? 3553 920 7412 3383 PMC9265087__F3 It Takes Two to Tango: A Review of Oncogenic Virus and Host Microbiome Associated Inflammation in Head and Neck Cancer 920 3458 7015 4609 23650 4277 PMC9266407__F3 Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses 4609 266710 8168 29882 1690 PMC9266652__F3 Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease 4615 114548 3553 64127 1397 PMC9267440__F1 Identification of Genetic Variations in the NAD-Related Pathways for Patients with Major Depressive Disorder: A Case-Control Study in Taiwan 130013 64577 125061 8564 8942 23498 23475 93100 203447 10135 PMC9267958__F3 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways 4088 3458 6714 6774 6772 PMC9267958__F4 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways 7099 4615 3569 PMC9267958__F5 Pharmacological Properties of 4′, 5, 7-Trihydroxyflavone (Apigenin) and Its Impact on Cell Signaling Pathways 7099 2885 1950 PMC9268066__F1 Progress and Prospects of Non-Canonical NFKB Signaling Pathway in the Regulation of Liver Diseases 7186 7187 4050 4049 4055 958 5971 PMC9270757__F3 Regulatory function of DNA methylation mediated lncRNAs in gastric cancer 1000 999 100316868 3486 3209 1499 57575 100124700 1956 6623 11332 8420 54797 1789 344887 5728 55384 864 653483 4204 6667 PMC9273796__F1 In silico structural and functional characterization of Antheraea mylitta cocoonase 1506 629 4666 7462 PMC9279119__F3 Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer 7097 4318 595 51701 5728 PMC9281180__F2 Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases 79792 114548 56169 637 1687 3002 7124 55876 581 3001 284110 3654 51135 7189 7099 23118 257397 8737 PMC9281252__F4 Molecular perspective on targeted therapy in breast cancer: a review of current status 2885 3480 5728 6009 5163 7249 7248 PMC9283764__F4 Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0) 2628 196 5468 7124 6908 51552 10870 2258 5467 950 9342 1062 PMC9284119__F5 Overexpression of TwSQS, TwSE, and TwOSC Regulates Celastrol Accumulation in Cambial Meristematic Cells and Dedifferentiated Cells 3652 5447 1644 PMC9286785__F5 BACE1: More than just a B‐secretase 3717 6774 3953 23621 7350 PMC9288447__F1 Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit 8822 6722 2261 PMC9289270__F1 LncRNA, an Emerging Approach for Neurological Diseases Treatment by Regulating Microglia Polarization 643 4929 51284 3596 7099 4627 4615 9023 PMC9290708__F1 Review article: therapeutic aspects of bile acid signalling in the gut‐liver axis 152831 2264 9965 1581 1582 1593 1594 PMC9297058__F1 Brain Abnormalities in PIK3CA-Related Overgrowth Spectrum: Physician, Patient, and Caregiver Experiences 5879 998 5728 2475 PMC9297732__F6 Multi-pronged anti-cancer activity of PI3KD inhibition in cancer 920 613 958 596 PMC9298824__F1 Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease 114548 9447 54106 115004 3661 PMC9299105__F2 Dengue Infection - Recent Advances in Disease Pathogenesis in the Era of COVID-19 716 720 721 PMC9300056__F2 Plant endoplasmic reticulum UPRome: A repository and pathway browser for genes involved in signaling networks linked to the endoplasmic reticulum 6185 7917 27161 PMC9300463__F2 Expression analysis of candidate genes in S. nux-vomica (strychnine producer) and Strychnos sp. (diaboline producer) 4149 124976 83985 PMC9301183__F1 NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes 59272 114548 79792 3553 PMC9305276__F4 Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation 1283 57506 3661 114548 3553 PMC9310808__F1 Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cthGAMP 9118 3661 115004 29110 PMC9313013__F1 Molecular Basis of Rare Diseases Associated to the Maturation of Mitochondrial [4Fe-4S]-Containing Proteins 2232 112812 2395 9054 3313 80273 134266 51218 388962 27247 81689 200205 11019 PMC9313262__F3 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) 7431 5329 7448 6647 151887 5054 891 595 801 5471 6790 7533 1398 4869 5606 7555 1634 22943 2896 1278 1277 3636 PMC9313262__F4 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) 7431 7168 6772 6647 151887 5054 595 5471 7150 1398 5329 4869 3157 83737 1634 22943 64778 2896 5606 3673 9219 PMC9313262__F5 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) 7450 7431 7272 3371 93663 6790 5055 801 5329 131566 4839 3673 3832 5606 PMC9313262__F6 High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP) 23780 6868 6773 1303 3456 6772 11328 5055 3105 3157 48 6647 5806 730 5631 3916 3956 5471 PMC9314626__F2 Metabolic dynamics instruct CD8+ T‐cell differentiation and functions 324 941 942 940 4609 2475 7249 7248 1374 6541 4976 PMC9315303__F7 Genistein promotes M1 macrophage apoptosis and reduces inflammatory response by disrupting miR-21/TIPE2 pathway 81671 4615 7099 PMC9315392__F3 B-Cell in the Pathogenesis of Systemic Sclerosis 933 613 930 941 29851 958 3569 3553 3586 170 5132 PMC9318110__F1 New Insights into TRP Ion Channels in Stem Cells 2260 7220 5015 7222 7225 7224 PMC9319012__F11 RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection 5970 4968 9945 6675 2673 64841 5238 PMC9320762__F4 Non-Canonical Programmed Cell Death in Colon Cancer 8737 8772 11035 197259 7099 7098 PMC9321501__F3 Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer 5371 6118 993 5706 11200 5829 4638 55388 5347 991 2099 3832 4751 11337 PMC9321501__F5 Investigating the molecular mechanisms of Tamoxifen on the EMT pathway among patients with breast cancer 1894 4638 51659 9212 79866 6790 29127 79682 151648 8835 9493 10112 5347 3619 55143 990 9055 10769 6777 332 2185 9021 55857 11143 PMC9322175__F2 Critical Roles of NFKB Signaling Molecules in Bone Metabolism Revealed by Genetic Mutations in Osteopetrosis 4790 5971 4050 PMC9323107__F2 Need for Individualized Risk Assessment in Cardiovascular Disease 7035 847 5340 PMC9323376__F8 Unkeito Suppresses RANKL-Mediated Osteoclastogenesis via the Blimp1–Bcl6 and NFKB Signaling Pathways and Enhancing Osteoclast Apoptosis 836 4772 100187907 81501 4318 PMC9323599__F3 Edwardsiella ictaluri T3SS Effector EseN Modulates Expression of Host Genes Involved in the Immune Response 3929 7097 10333 929 5879 1674 114609 54106 7098 23118 7189 3665 3661 958 942 6769 PMC9326486__F1 Therapeutic Potential of Targeting NIK in B Cell Malignancies 5971 7186 7187 PMC9327801__F9 Isolation, Biosynthesis, and Biological Activity of Polycyclic Xanthones From Actinomycetes 6476 718 717 PMC9329130__F1 Over-expression of a cyanobacterial gene for 1-deoxy-d-xylulose-5-phosphate synthase in the chloroplast of Chlamydomonas reinhardtii perturbs chlorophyll: carotenoid ratios 718 1431 3652 PMC9330518__SF1 Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy 961 140885 8205 PMC9331760__F4 HDACs in the Response of Cancer Cells to Cellular Stress and the Potential for Therapeutic Intervention 9817 23411 4094 8841 3065 571 PMC9331798__F7 Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage 3553 2475 8600 PMC9332053__F2 MTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data 958 920 613 2475 324 4397 114548 4342 PMC9334696__F2 Biopolymeric nanoparticles based effective delivery of bioactive compounds toward the sustainable development of anticancerous therapeutics 6010 340451 581 PMC9336529__F2 Clinical potential of the Hippo-YAP pathway in bladder cancer 9113 55793 4485 81788 PMC9336529__F3 Clinical potential of the Hippo-YAP pathway in bladder cancer 55793 998 388 389 387 PMC9339642__F1 Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers 100128191 283131 100505881 100124700 79184 9043 23411 641638 100506660 6480 3159 2475 10481 2638 5728 2591 6935 3667 6774 3717 6624 9113 55294 9839 10413 1956 607 999 2308 324 80086 693222 4498 100505633 200772 541471 55384 85028 283120 PMC9340544__F5 Heme Biosynthetic Gene Expression Analysis With dPCR in Erythropoietic Protoporphyria Patients 211 212 2235 5498 210 1371 7390 7389 3145 PMC9342591__F1 Cast of characters 7040 2735 7477 80326 1499 3606 3569 PMC9343807__F1 Hippo–YAP/TAZ Signaling Pathway in Intestinal Self-Renewal and Regeneration After Injury 4771 4485 9113 26524 PMC9350720__F1 Complement-mediated microvascular injury and thrombosis in the pathogenesis of severe COVID-19: A review 718 727 721 10747 1431 PMC9352970__F2 Cardiovascular protection by SGLT2 inhibitors – Do anti-inflammatory mechanisms play a role? 7412 3383 7124 2475 114548 PMC9353242__F2 Hedgehog signaling regulates the development and treatment of glioblastoma 79923 9444 129807 6608 9231 2736 145258 PMC9355504__F1 Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer 84530 6774 5978 2475 7039 3481 6657 6690 3170 79923 117581 3579 367 PMC9356043__F9 Virus-host interaction analysis in colorectal cancer identifies core virus network signature and small molecules 999 7157 1017 1001 7913 8653 1654 PMC9359065__F1 PERK promotes immunosuppressive M2 macrophage phenotype by metabolic reprogramming and epigenetic modifications through the PERK-ATF4-PSAT1 axis 3565 468 29968 26227 4280 PMC9359082__F2 CMTM6 and CMTM4 as two novel regulators of PD-L1 modulate the tumor microenvironment 11166 999 2475 1499 54918 146223 1003 PMC9359433__F1 RET signaling pathway and RET inhibitors in human cancer 64096 2674 2676 2675 6774 5623 9048 4902 2668 2886 2887 5979 6714 2885 3667 8660 55816 79930 1796 55715 9046 10818 85358 PMC9359433__F2 RET signaling pathway and RET inhibitors in human cancer 5979 6774 3717 PMC9360899__F1 PI3K/AKT signaling pathway in gallbladder carcinoma 1956 6667 5728 1755 PMC9361353__F4 Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway 4153 5648 10747 717 718 727 730 729 735 PMC9362167__F4 Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective 114548 6774 2475 PMC9363660__F1 Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation 325 920 3458 7124 613 10113 PMC9363660__F3 Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation 7124 3458 920 PMC9366743__F6 Beta-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGFB/Smad Signaling Pathway 4088 4087 4089 7046 PMC9367355__F3 The Cancer Stem Phenotype by Long Non-Coding RNAs 6670 100505994 25776 960 6657 6934 10642 PMC9367504__F7 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis 3579 2919 4615 PMC9367540__F2 Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders 7019 54209 3661 29110 7099 115004 54106 PMC9368778__F5 Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant 115004 29110 3661 4485 9113 26524 PMC9368893__F3 Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia 3479 3481 581 2475 PMC9371865__F8 LTBP2 Knockdown Promotes Ferroptosis in Gastric Cancer Cells through p62-Keap1-Nrf2 Pathway 4053 9817 2879 PMC9372260__F4 Integrated analysis of multiple bioinformatics studies to identify microRNA-target gene-transcription factor regulatory networks in retinoblastoma 8318 8317 4172 699 4176 4171 991 4175 990 1869 9133 6241 51512 7298 1503 5893 83990 8438 PMC9372960__F1 Deucravacitinib for the Treatment of Psoriatic Disease 29949 3716 3717 2056 7173 3718 7297 PMC9373414__F1 CHAMP-study: the CHemopreventive effect of lithium in familial AdenoMatous Polyposis; study protocol of a phase II trial 324 147111 27123 11197 PMC9376115__F2 Regulated cell death (RCD) in cancer: key pathways and targeted therapies 8717 7186 355 8772 637 581 6774 PMC9376115__F5 Regulated cell death (RCD) in cancer: key pathways and targeted therapies 147945 114548 58484 9447 79792 22861 56169 55876 PMC9382085__F8 Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NFKB/STAT3 pathway in mice as revealed by network pharmacology study 6774 581 4318 PMC9386495__F9 Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability 4553 3988 3652 2821 PMC9389066__F2 Pyroptosis and inflammasomes in diabetic wound healing 1687 56169 79792 114548 PMC9389749__F1 Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma 10071 648 7422 1788 PMC9395689__F3 RAGE pathway activation and function in chronic kidney disease and COVID-19 5879 7225 1729 4851 PMC9395689__F4 RAGE pathway activation and function in chronic kidney disease and COVID-19 1636 4087 4088 PMC9396337__F9 Electroacupuncture improves TBI dysfunction by targeting HDAC overexpression and BDNF-associated Akt/GSK-3B signaling 627 2932 581 3065 8841 2670 3569 PMC9396350__F6 Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection 7099 2056 3717 2057 11091 11213 8685 7424 PMC9396390__F2 Targeting tumor microenvironment for cholangiocarcinoma: Opportunities for precision medicine 920 6347 4283 PMC9399075__F2 Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease 29956 253782 79603 10715 PMC9399632__F3 Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics 8717 7186 8772 637 331 581 PMC9403516__F8 Astragaloside IV promotes pharmacological effect of Descurainia sophia seeds on isoproterenol-induced cardiomyopathy in rats by synergistically modulating the myosin motor 7169 7168 4878 PMC9403860__F1 How the crosstalk between innate immune sensors and metabolic pathways affect the outcome of Brucella abortus infection? 3091 2475 4615 9447 3553 PMC9404549__F9 Salvia chinensis Benth Inhibits Triple-Negative Breast Cancer Progression by Inducing the DNA Damage Pathway 3014 472 545 5888 2177 PMC9404709__F2 Understanding the Mechanism of Action of Melatonin, Which Induces ROS Production in Cancer Cells 275 23410 23411 PMC9406534__F3 TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer 57506 7186 3661 29110 PMC9406657__F2 PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer 5163 7249 5728 2308 4193 PMC9406852__F1 Transcriptome Profiling Reveals Differential Expression of Circadian Behavior Genes in Peripheral Blood of Monozygotic Twins Discordant for Parkinson’s Disease 191 6715 9572 7157 5730 9112 4987 4669 80045 PMC9406872__F1 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer 51684 2735 64399 5727 2737 2932 2736 6608 PMC9408811__F2 Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa? 114548 3553 114609 7099 140609 4615 PMC9408827__F3 Cartilage Oligomeric Matrix Protein, Diseases, and Therapeutic Opportunities 1311 1280 1297 860 1300 249 PMC9412305__F4 The Innate Immune Response during the Human Papillomavirus Life Cycle 355 637 581 331 PMC9414852__F8 MOBT Alleviates Pulmonary Fibrosis through an lncITPF–hnRNP-l-Complex-Mediated Signaling Pathway 4087 4088 4089 3191 4208 342184 8407 PMC9418006__F7 Metabolic pathways encoded by Comchoano-1 and Comchoano-2 consolidated from Pathway Tools 1611 4397 4151 100187761 8205 1674 PMC9428757__F5 Thioredoxin-interacting protein: A new therapeutic target in bone metabolism disorders? 10628 114548 79792 834 PMC9433531__F4 Mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations 1956 1950 2475 PMC9434901__F9 Oleuropein inhibits invasion of squamous cell carcinoma of the head and neck through TGFB1 signaling pathway 4087 4088 4089 PMC9436575__F6 Preventive Electroacupuncture Alleviates Oxidative Stress and Inflammation via Keap1/Nrf2/HO-1 Pathway in Rats with Cyclophosphamide-Induced Premature Ovarian Insufficiency 9817 4094 7124 3569 PMC9437264__F12 CGMP/Akt/GSK-3B signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacing 5225 7408 2932 PMC9439853__F4 Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review 468 6774 650 860 PMC9441553__F5 Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway 60343 1356 5660 5051 351 2582 796 4082 114898 11181 PMC9441790__F3 Primary cilium in kidney development, function and disease 324 2932 27130 1499 PMC9442310__F7 miRNAs‐mediated control of MOV10 expression regulates L1 retrotransposition in mESCs 54487 29102 4343 1656 PMC9444456__F2 Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain 706 7124 3579 2919 627 PMC9445272__F8 CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3B/Beta-catenin pathway 1025 23678 1499 595 2932 PMC9445622__F1 Akt isoforms in the immune system 208 406947 406887 941 942 PMC9446423__F2 Endocrine therapy resistance: what we know and future directions 6667 2113 2002 7249 7248 PMC9448813__F2 Notch signaling pathway 102 6868 3280 23462 PMC9452720__F1 How zoledronic acid improves osteoporosis by acting on osteoclasts 7189 3550 100187907 1513 PMC9454092__F6 Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke–induced model of chronic obstructive pulmonary disease 4089 4087 4088 2660 1431 PMC9454586__F2 Oncostatin M: From Intracellular Signaling to Therapeutic Targets in Liver Cancer 9021 3716 6772 6774 3717 6778 PMC9454744__F3 Small Nucleolar RNAs and Their Comprehensive Biological Functions in Hepatocellular Carcinoma 677809 767561 26799 692088 100170220 4193 692086 2263 692196 100113391 26797 PMC9454979__F6 Novel Insights into miR-944 in Cancer 6774 6772 122809 1154 6714 4193 346389 2638 1950 1499 1956 2627 PMC9457820__F6 Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges 2932 1499 324 3569 PMC9458461__F6 Nuclear DNA damage response by mitochondrial morphofunctional pathway 55669 9927 472 672 PMC9461128__F2 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential 163732 8089 4609 284252 7021 7316 7157 10370 6860 4435 PMC9461128__F3 Regulatory role of AP-2B in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential 7054 4129 1312 1621 5409 PMC9463538__F12 MAP3K4 promotes fetal and placental growth by controlling the receptor tyrosine kinases IGF1R/IR and Akt signaling pathway 4216 10013 5163 PMC9464648__F2 From cerebral ischemia towards myocardial, renal, and hepatic ischemia: Exosomal miRNAs as a general concept of intercellular communication in ischemia-reperfusion injury 29102 54487 27161 3181 PMC9465037__F2 Bacterial cyclic di-adenosine monophosphate in the host immune response 51428 3661 114548 PMC9465411__F5 Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents 7412 10298 1499 PMC9468863__F2 Impact of local anesthetics on epigenetics in cancer 693122 6659 5728 694 2475 1956 PMC9468871__F3 Network-based pharmacological investigation to identify the mechanistic regulatory pathway of andrographolide against colorectal cancer 2475 3815 5156 5468 3265 5781 6714 2099 5594 PMC9476742__F4 Emerging therapeutic role of Prunella vulgaris in thyroid disease 11140 7186 8717 1540 836 PMC9477421__F5 Schematic diagram summarising the inferred functions of cofilin 1 (CFL1) and fatty acid binding protein 5 (FABP5) that interact with a prokaryotically-expressed (non-glycosylated) recombinant form of the Toxocara canis mucin 1 protein (rTc-MUC-1) 2171 4199 7316 3936 4738 5216 11151 389 7534 3320 71 10487 PMC9477794__F2 Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy 4615 5970 114548 3553 PMC9478335__F3 Adipose tissue macrophage in obesity-associated metabolic diseases 3667 7124 3553 PMC9479306__F1 Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications 407009 100302156 6423 324 1499 693128 9839 7048 387 4089 7046 4088 4087 998 999 4092 100302177 1000 29102 PMC9479340__F1 Tumor accomplice: T cell exhaustion induced by chronic inflammation 8205 3082 1950 PMC9481235__F1 AIM2 Gene and AIM2 Inflammasome in the Pathogenesis and Treatment of Psoriasis 9447 7054 59082 6790 51284 54106 PMC9481585__F6 Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355 2157 717 5880 PMC9482322__F7 Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma 4613 302 7018 2475 55902 2194 6319 PMC9490723__F1 Proviral role of caspase-6 57506 3661 3665 83939 468 PMC9491525__F6 Putative BvrR/BvrS TCS regulon in B. abortus upon entry into the host cell 5662 2597 7086 5813 3258 PMC9495336__F3 Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry 9817 23657 23411 PMC9495868__F4 Suppressing the PI3K/AKT Pathway by miR-30d-5p Mimic Sensitizes Ovarian Cancer Cells to Cell Death Induced by High-Dose Estrogen 6045 7321 4734 4193 7322 836 4851 3660 3480 9126 331 7323 330 329 351 142 6477 5879 1616 6426 648 7532 472 2547 5591 1021 9636 55660 4214 3192 7324 11335 51343 23327 23468 6432 10146 11091 6871 10284 7157 8452 4670 9734 8945 6498 1213 7428 5111 1665 5599 1655 27339 28996 6885 2146 7534 3838 861 9775 4086 7528 4627 5501 983 6670 4609 367 55588 29110 10492 3725 5689 7431 595 604 2023 6175 3676 8453 6612 8202 6118 9632 26986 4087 3320 10971 9657 2335 8065 5966 3303 1654 1778 5903 3837 801 6176 6210 1915 54165 PMC9497316__F8 Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes 1421 1412 1417 1356 1410 10461 1182 3791 7045 842 PMC9504097__F2 Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure 114548 3606 7082 PMC9504568__F10 1,25-Dihydroxyvitamin D3 Negatively Regulates the Inflammatory Response to Porcine Epidemic Diarrhea Virus Infection by Inhibiting NFKB and JAK/STAT Signaling Pathway in IPEC-J2 Porcine Epithelial Cells 7421 9021 6772 6774 PMC9506554__F1 Genetic Variants in One-Carbon Metabolism and Their Effects on DHA Biomarkers in Pregnant Women: A Post-Hoc Analysis 4522 4524 6470 635 10400 PMC9507777__F4 Single-Cell Transcriptome Analysis Reveals Different Immune Signatures in HPV- and HPV + Driven Human Head and Neck Squamous Cell Carcinoma 5132 920 4282 3569 PMC9508095__F9 Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin A7 is counteracted by TBK1-p62 axis-mediated autophagy 3661 7187 29110 PMC9508642__F8 Perindopril sensitizes hepatocellular carcinoma to chemotherapy: A possible role of leptin / Wnt/ Beta-catenin axis with subsequent inhibition of liver cancer stem cells 324 1499 6774 619501 4318 PMC9509228__F2 Mitochondrial-Endoplasmic Reticulum Communication-Mediated Oxidative Stress and Autophagy 11337 139341 816 664 2475 22926 5289 7186 83939 PMC9511797__F2 Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer 7157 5728 5163 PMC9513079__F2 Interaction between LSC and BMM 9242 6387 2475 7852 960 PMC9516659__F2 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data 387103 64946 1058 64105 79019 91687 2099 25861 144203 11234 699 10990 6509 10178 2220 4693 51660 2687 10747 8547 4153 PMC9516659__F3 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data 55388 699 1874 2308 7153 55684 7157 1869 2305 1063 701 2146 4751 4171 PMC9519344__F3 Mitochondrial Unfolded Protein Response: A Novel Protective Pathway Targeting Cardiomyocytes 83939 468 22926 PMC9521683__F2 The POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes 2308 3643 6774 5335 7224 5140 23237 181 3717 3953 PMC9524954__F7 Alpha-KG production pathways that add net carbons to TCA cycle from glutamine 2806 84706 6576 PMC9526899__F3 Omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows 51085 7038 2194 4099 11343 2167 747 3569 PMC9528772__F8 Sirt6 deficiency contributes to mitochondrial fission and oxidative damage in podocytes via ROCK1‐Drp1 signalling pathway 51548 6093 118 PMC9530146__F6 Mechanisms of acupuncture for neuropathic pain based on somatosensory system 1524 627 6376 PMC9531511__F1 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis 115004 29110 3661 PMC9531511__F5 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis 9447 115004 79792 3553 PMC9533025__F4 Estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes 3485 9518 26291 656 145957 3569 3479 PMC9545774__F1 Hypoxia in the tumor microenvironment and targeted therapy 2475 664 102 100507436 PMC9546099__F5 Absorption, metabolism and excretion of opicapone in human healthy volunteers 717 1490 4397 PMC9547189__AF1 miR21 modulates the Hippo signaling pathway via interference with PP2A BB to inhibit trophoblast invasion and cause preeclampsia 406991 4485 9113 1499 PMC9549360__F4 Regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface 51441 56339 10392 54915 79068 6772 8651 2475 54541 7099 10644 PMC9550461__F4 Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases 10267 50507 6714 6774 1956 PMC9551033__F4 AMBRA1 and its role as a target for anticancer therapy 55626 4089 219 9021 5728 1499 6774 PMC9552878__F4 Two facets of receptor tyrosine kinase in cardiovascular calcification—can tyrosine kinase inhibitors benefit cardiovascular system? 26291 2260 8074 860 4488 PMC9555085__F2 Current understanding of epigenetics role in melanoma treatment and resistance 3480 3479 3488 8085 1356 9869 2668 5979 6714 2674 2308 10873 1499 147906 153090 2146 154 PMC9558279__F1 PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond 5741 2778 4208 9759 PMC9559463__F3 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives 6608 5727 51684 920 PMC9559463__F5 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives 6608 51684 5727 940 3902 324 3458 7124 PMC9561999__F6 Good, the Bad and the New about Uric Acid in Cancer 2475 6009 7248 7249 PMC9563396__F5 Molecular Mechanism of Ferroptosis in Orthopedic Diseases 6774 23657 2879 PMC9570242__F6 Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep 4089 4087 4088 185 7220 7222 84876 PMC9570477__F7 An Integrative Transcriptional Network Revealed Spatial Molecular Interplay Underlying Alantolactone and Inulin Biosynthesis in Inula racemosa Hook f. 412 7360 6750 PMC9572668__F3 Molecular Mechanisms and Health Benefits of Ghrelin: A Narrative Review 2693 7099 114548 3553 PMC9575643__F2 Cellular, molecular, metabolic and epigenetic approaches to studying trained immunity 7099 3553 7124 PMC9576970__F2 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach 367 5625 83483 51338 PMC9576970__F3 Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach 6373 6721 29881 6667 3576 2919 64240 PMC9578220__F6 Novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients 3109 959 3135 153579 7293 961 8784 PMC9579211__F4 Ethnomedicinal uses of Indian spices used for cancer treatment: A treatise on structure-activity relationship and signaling pathways 3717 23468 6776 PMC9580515__F5 Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages 6774 6778 961 2475 PMC9581482__F8 Proposed model of LXR inhibition by oxysterol misbalance contributes to inflammation and fibrosis in murine WD 540 4280 7038 2194 7076 PMC9583547__F1 Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex 367 6462 2561 2555 PMC9586150__F3 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis 6678 4638 7046 3984 5728 5447 94005 595 1462 2152 154 9760 351 3952 1281 4149 650 54331 2353 PMC9586150__F6 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis 7046 7048 759 4099 PMC9592233__F5 Lipid Profiling of Pacific Abalone (Haliotis discus hannai) at Different Developmental Stages Using Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry 4018 7038 5091 PMC9592927__F2 Emerging role of circular RNAs in drug resistance of non-small cell lung cancer 1956 10863 6774 PMC9593054__F2 NLRP3-mediated pyroptosis in diabetic nephropathy 100187761 23409 2305 7099 331 23411 2475 114548 7503 79792 PMC9593054__F5 NLRP3-mediated pyroptosis in diabetic nephropathy 2146 1374 2475 2932 3479 114548 PMC9593054__F6 NLRP3-mediated pyroptosis in diabetic nephropathy 2475 56339 5728 1654 114548 23411 79792 PMC9596769__F3 Immunomodulatory potential of secretome from cartilage cells and mesenchymal stromal cells in an arthritic context: From predictive fiction toward reality 1234 3578 3569 3565 50616 3586 3091 3479 7421 6469 PMC9598206__F7 GPX4 Alleviates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting Ferroptosis 2182 10162 2879 PMC9598787__F7 Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation 8717 9021 4170 PMC9598867__F2 Redox-Regulation in Cancer Stem Cells 9817 3162 1728 2729 2946 2948 2947 2944 2938 4363 79923 6469 PMC9600014__F1 Amyloidogenesis and Neurotrophic Dysfunction in Alzheimer’s Disease: Do They have a Common Regulating Pathway? 23163 351 23621 PMC9601310__F7 Sorting nexin 17 increases low-density lipoprotein receptor-related protein 4 membrane expression: A novel mechanism of acetylcholine receptor aggregation in myasthenia gravis 4038 4593 9784 PMC9602304__F1 Emerging Role of MicroRNAs and Autophagy Mechanism in Pancreatic Cancer Progression: Future Therapeutic Approaches 29102 5901 27161 84560 PMC9602906__F8 Exosomes Derived from Adipose-Derived Mesenchymal Stem Cells on Pyroptosis and Regeneration of Injured Liver 1499 7099 79792 114548 PMC9603380__F12 Binding of Gamma-Glutamyl Transferase to TLR4 Signalling Allows Tissue Factor Activation in Monocytes 3654 51135 4615 7189 114609 7099 7018 PMC9605185__F3 Towards Precision Oncology: The Role of Smoothened and Its Variants in Cancer 6608 156 132884 387 51684 5879 10892 8915 PMC9605952__F2 Ubiquitination on ferroptosis 960 10057 55611 23657 9817 8237 57534 PMC9606346__F7 Combined analysis of the transcriptome and proteome of Eucommia ulmoides Oliv. (Duzhong) in response to Fusarium oxysporum 1998 468 596 PMC9608775__F1 MicroRNA-383: A tumor suppressor miRNA in human cancer 10935 835 5987 595 10038 57650 6935 9839 6664 1063 3659 64221 5935 8091 5080 261726 PMC9614042__F10 LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing 7099 4615 51135 10291 PMC10035756__F5 State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer 324 1499 5970 6608 PMC10036500__AF1 MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway 23499 324 1499 6925 PMC10037252__F2 Systemic treatment for metastatic colorectal cancer 1956 3667 8660 2475 PMC10037657__F3 Long Noncoding RNA H19: A Novel Oncogene in Liver Cancer 2475 283120 2146 619501 PMC108887__F9 The CD5-induced signaling pathway, which is mediated by PI 3-kinase and Vav, resulting in the activation of Rac1 921 920 3932 2534 PMC1190355__F8 A model of IRAK1c regulation of inflammation 51135 4615 7189 54472 PMC1304643__F2 Probability flux distributions for human red blood cell 7086 100 84890 7084 2597 22944 PMC139401__F2 TLR signal transduction pathways 7097 7099 4615 114609 4118 7189 6772 3553 PMC139865__F12 Innate immunity pathways in Drosophila 7189 5966 4791 4790 PMC140098__F7 A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer 6010 2274 367 PMC1480427__F1 ω3 LC-PUFA and ω6 LC-PUFA biosynthetic pathways 2717 1896 355 PMC1482580__F4 EDA signaling in hair follicle development 128178 10913 22943 27121 25928 6469 5971 4050 PMC1553448__F7 Transcript expression of BMP signaling pathway members 1634 4089 3399 3397 3398 3400 7048 7046 7042 657 659 PMC166813__F1 The GA biosynthetic pathway in pea 340451 100188864 6588 PMC1698952__F4 Aspects of PRLR signaling as related to mammary gland function 5618 5617 7006 100124696 3717 6714 3667 2885 PMC1756898__F1 Unraveling the Genetics of Human Obesity 5443 4160 3953 4852 181 2690 627 PMC1775040__F4 WNT Pathways 6010 324 2932 PMC1820751__F3 Ras signaling pathway relays growth signals from activated growth factor receptors to the nucleus 2885 4763 1431 9846 PMC182218__F2 Osteoblasts express components necessary for coordinating mineralization of ECM and phosphate handling by the kidney 8074 5251 5741 1499 56955 PMC1853294__F10 Cell injury to wound closure, including P2Y activation, intracellular Ca2+ release and EGFR signaling 6714 1956 2064 PMC1855990__F2 Identification of Key Processes Underlying Cancer Phenotypes Using Biologic Pathway Analysis 100187761 1387 3815 PMC1860011__F2 PPARG as a new therapeutic target in inflammatory bowel diseases 2353 3725 7412 3383 PMC1867237__F3 ErbB/Ras pathway and Wnt pathway 7480 2064 1855 2932 324 1499 4609 PMC1876696__F1 Pathways for the synthesis of the major phospholipids in S 10400 5662 5091 7038 780904 907 100379198 3652 PMC1905845__F1 Schematic representation showing the plausible signaling events from uPAR integrin complex 5340 355 8772 2475 5728 572 PMC1940051__F2 TGFB signaling pathway 7046 4087 4088 4089 3082 PMC1952636__F9 Beta-Arrestin–mediated B1-adrenergic receptor transactivation of the EGFR confers cardioprotection 6714 1839 1956 2869 PMC1993861__F7 Model summarizing the hypothesis on narciclasine-mediated apoptosis 355 637 581 8772 PMC1999497__F2 Flow diagram of the P53/apoptosis pathway 596 581 317 PMC2042178__F2 PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation 5728 2475 6774 PMC2045624__F1 OX40 signaling directly triggers the antitumor effects of NKT cells 940 912 941 958 942 920 PMC2074956__F3 Schematic representation of the carbon catabolic pathway, the bifid shunt, and oxalic acid degradation 175 2821 8213 PMC2082051__F5 Networks of pathways unique in the HIV-1 regulated mPBMCs 3108 1493 3123 7535 673 1848 5595 3109 3122 6195 51744 7305 3822 5777 PMC2089068__F3 Relative transcript levels for genes from carbon central metabolism for PB12 (first value) and PB13 (second value), as compared to JM101 85569 6120 1896 4118 6389 6390 6391 11113 PMC2089068__F4 Relative transcript levels for genes from carbon central metabolism for L-Phe overproducing strains 85569 22934 6120 1896 4118 6389 6390 6391 11113 PMC2118167__F7 Proposed model for the intersection of innate and adaptive immunity during polysaccharide-induced abscess formation in the peritoneal cavity 7097 6775 940 PMC2131730__F4 LPS signals the TLR4 pathway on an APC (i.e., monocyte or dendritic cell) 3929 7099 929 114609 4615 PMC2153443__F8 TGFB SIGNALING BY PROINFLAMMATORY CYTOKINES IN ARTICULAR CHONDROCYTES 3553 7018 6965 PMC2172299__F8 A hypothetical model showing the roles of Fak and paxillin in motile HeLa cells 1398 1000 5879 PMC2176131__F7 Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–B Signaling 1950 1956 4087 4088 4092 PMC2202913__F1 Control of Food Intake by the Hypothalamic Leptin-Melanocortin PathwayThe hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis 5443 181 23237 PMC2224366__F9 Innate immune modulation of CTL response to LCMV through MyD88 signaling 4615 5132 51284 54106 PMC2242750__F1 Schematic representation of GADS-related signaling in T cells 3702 5335 9846 27040 PMC2259386__F1 Prototypical myelin-derived neurite growth inhibitors, their receptors and intracellular signaling pathway 4099 84894 6010 1956 PMC2263022__F6 Superposition of 'omics' data on maps 472 9618 581 7508 5111 324 1063 1058 7272 1062 PMC2277498__F3 Pharmokinetic Limitations of Antioxidant Treatment for COPD 7124 351 572 637 5970 331 8717 7186 8772 PMC230332__F7 Extracellular and intracellular antagonism of BMP signaling by myostatin and TGFB 650 655 4087 4088 4090 4086 PMC2410298__F1 TOLL-LIKE RECEPTORS REGULATION OF VIRAL INFECTION AND DISEASE 7096 7097 10333 7099 57506 7098 54106 51284 PMC2448841__F5 Proposed model of arrest of maturation/activation of DCs via ILT4 receptor and HLA-G ligand 3135 4615 1445 6774 3663 7189 7099 PMC2477698__F1 Examples of the molecular mechanisms by which phytochemicals activate hormetic stress response pathways 627 4803 3479 9817 23411 PMC2495063__F3 Germline Mutations and Variants in the Succinate Dehydrogenase Genes in Cowden and Cowden-like Syndromes 5728 7249 2475 3091 PMC2516940__F2 Sepsis and insights from clinical trials 7099 4118 4615 3661 PMC2517702__F3 Signal transduction in the CD95 pathway 8772 637 836 PMC2518081__F3 The pathways involved in polycystic kidney disease 5091 1080 551 PMC2518463__F2 Binding of specific signalling proteins to phosphorylated tyrosine residues on KIT following receptor activation and the subsequent signalling events leading to mast cell responses 3815 2534 4067 695 2885 1398 3717 6772 6774 PMC2519632__F6 Proposed model of KSHV-induced lymphatic reprogramming of endothelial cells 3717 6774 5629 PMC2525561__F4 Schematic diagram of in vivo n3 VLC-PUFA biosynthetic pathway mediated by ELOVL4 and other ELO families [modified after Suh and Clandinin ()] 60481 54898 83401 64834 6785 PMC2536824__F4 Ingenuity Pathway Analysis (IPA) of genes specifically overexpressed in B1-Arg389 transgenic mouse hearts 2335 1909 5602 27086 6498 7072 PMC2538513__F2 The involvement of death receptor pathway (right half) and mitochondrial pathway mediated (left half) apoptosis in nurse cell formation 7124 8717 8772 7186 317 PMC2556249__F2 Insulin receptor signaling 2885 3667 5266 PMC2570606__F6 Proposed model for the effects of hypoxia-induced energy stress on them TOR pathway in HNSCC cells 7248 7249 6009 2475 PMC2574839__F2 Androgen synthesis pathway and therapeutic targets 3283 3284 6715 6716 PMC2577004__F1 Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-ALL 4851 4609 4149 3280 5728 9794 2475 55294 PMC2581748__F2 Activation of the mammalian target of rapamycin (mTOR) pathway can result from numerous glioma-associated genetic changes 4763 5728 2475 6009 PMC2593508__F8 Fasudil inhibits the myogenic response in the fetal pulmonary circulation 2638 387 6010 PMC2593565__F3 Epithelial barrier function by lactobacilli 4049 1956 4615 PMC2597223__F1 Pathways of apoptosis 8772 581 637 23237 331 PMC2600878__F6 Syk signaling is necessary for E-selectin-induced LFA-1-ICAM-1 association and rolling but not arrest 3579 6850 2919 3383 PMC2613125__F6 Interleukin-6 and Neural Stem Cells: More Than Gliogenesis 627 4803 8136 1950 1270 PMC2613930__F4 Genes that contain the 100 most differentially methylated CpG sites between normal and lung cancer tissue samples (p-value < 0.005) 3207 4654 51214 4852 914 3481 653509 4100 5777 7124 1113 7161 5179 4342 1080 7490 3356 4691 5443 7015 4747 2587 PMC2627520__F2 Biosynthesis of Natural and Hyperelongated Chondroitin Sulfate Glycosaminoglycans: New Insights into an Elusive Process 79586 337876 22856 1431 PMC2630276__F7 Model for the role of Hedgehog in the recovery of the BMP4-dependent stress erythropoiesis pathway in the spleen 652 50846 3549 PMC2631307__F1 Glucocorticoids and neonatal brain injury: the hedgehog connection 6608 1325 6469 2735 3479 PMC2631402__F4 The Legionella pneumophila replication vacuole: making a cozy niche inside host cells 6389 664 10392 64127 PMC2634670__F1 Strategies to inhibit the VEGF signalling pathway 100187907 5281 54567 PMC2634968__F2 Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling 7097 3661 3665 PMC2637898__F2 EGFR signaling pathways 2885 5728 7249 2475 PMC2639747__F2 Smad3 in TGFB–mediated proapoptotic transcriptional responses 2475 4616 596 PMC2643306__F1 Structure-function relationships in methionine adenosyltransferases 4397 635 875 PMC2643336__F3 From the diet to the nucleus: Vitamin A and TGFB join efforts at the mucosal interface of the intestine 4088 6774 50943 PMC2660327__F2 Network analysis using Ingenuity pathway analysis (IPA) software 3791 6714 1499 596 572 PMC2670830__F4 Signaling in pterygium 4286 348 1475 4782 7832 7391 6876 3725 2353 3486 1958 6670 7052 6678 PMC2672206__F7 Regulation of osteogenic differentiation of MC3T3-E1 cells by substrate rigidity 860 718 387 PMC2675987__F1 Calmodulin-dependent nuclear import and disease 6662 6736 5901 PMC2683291__F4 Mammalian target of rapamycin (mTOR) signalling cascade 7249 6009 2475 1977 PMC2689231__F6 Purine biosynthetic pathway, showing protein abundance changes for the P 5814 7808 132 5813 PMC2691147__F1 Hh signalling—a simplified model 51684 5727 6608 PMC2694829__F6 HIV-1 TAT T cell receptor signaling pathway 759 27040 140609 PMC2695822__F10 Display of genes with high expression in CT embryos 4922 2688 23788 23022 7157 PMC2703803__F1 The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target 210 7909 7390 7389 130749 PMC2707240__F2 Proposed model for As2O3-dependent activation of the mTOR pathway in a negative feedback regulatory manner in malignant cells 2475 1975 1977 27250 6194 PMC2710681__F4 Model describing TLS across CPD in human cells 27434 51426 5428 PMC2712453__F6 TLR-mediated innate immune signaling pathway 7099 7100 54106 51284 3554 7096 7097 10333 7098 51311 81793 4615 8772 355 7132 3717 3552 6850 3932 3716 925 7124 3454 3572 3587 3586 3569 3456 3105 3556 941 3458 PMC2712626__F1 The Double Life of Irs 2308 8660 3667 3170 7038 PMC2713319__F1 Apoptosis and Epithelial Injury in the Lungs 355 8772 637 PMC2713319__F3 Apoptosis and Epithelial Injury in the Lungs 7099 355 929 8772 4615 3553 PMC2715245__F7 Comparison of models for FRAXA and APC-inducible chromosome fragility 324 545 472 PMC2719559__F2 Paracrine and autocrine mechanisms of Akt-mediated tumor-stromal interactions 3479 7852 6352 1234 PMC2721689__F1 Structural and functional modules in RNA interference 29102 54487 192669 6037 PMC2726075__F1 EGFR signaling pathway 1950 595 4609 PMC2731675__F3 FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION 2638 613 958 3552 5091 PMC2737000__F4 TNF-induced NFKB and apoptosis pathways 7124 355 1459 8772 8795 8717 7186 599 637 665 3551 5578 2932 329 4170 1029 5970 PMC2737000__F6 Androgen receptor pathway 6840 573 367 3290 5325 5742 PMC2756538__F3 A model for the role of eEF-2K in the induction of autophagy during amino acid starvation and ER stress 83939 29904 1938 PMC2757291__F6 The SLAM-Associated Protein (SAP)/Fyn/PKCθ Pathway is Required for Thymocyte-mediated CD4 T Cell Development 324 7006 100124696 2534 PMC2766863__F2 Signalling crosstalk in B cells: managing worth and need 613 930 4067 7187 6850 5336 2885 29760 7186 5971 8915 5966 PMC2768836__F1 Role of clathrin adaptor proteins in melanosome biogenesis 8411 63971 7018 PMC2770888__F2 Targeting EGFR resistance networks in Head and Neck Cancer 6714 2885 6774 5728 572 2475 595 PMC2773962__F6 Model of Tbx2 function for the EC formation in the AVC 6909 7042 657 3037 650 652 PMC2776915__F1 A genetic model for sex determination, controlled by a balance of antagonistic pathways 6662 54361 284654 2254 6736 668 399823 1499 PMC2781509__F1 Folate-mediated one-carbon metabolism 4524 84890 6470 PMC2788597__F3 Metabolic pathway of pitavastatin 1559 54658 54659 7364 1565 1576 PMC2789271__F1 Gene selection in the TGFß signaling pathway 7040 7042 7043 7049 7046 7048 4089 4087 4088 4090 4086 4092 4091 7018 PMC2803240__F8 Model of VA metabolism in neonatal rat lung 9227 56603 64220 PMC2804177__F9 The signaling pathways regulating osteoblast-like cells proliferation in response to OSS 1019 1021 1017 PMC2805793__F1 Ligand binding and subsequent Erbb dimer formation initiates signaling through a complex array of intracellular pathways that initiate and control a range of cellular processes 2064 2065 2885 5728 2475 2932 572 PMC2806892__F1 Methionine metabolism in vivo 4397 635 100188776 875 PMC2808058__F1 Schematic of the Notch pathway 655 5663 4851 102 54626 23462 PMC2808058__F2 The effects of the SOX4 and HOXC6 transcriptional networks on PI3K-AKT pathway activation in prostate cancer 6659 4851 28514 3486 1956 53834 3482 1499 2263 PMC2818736__F1 Colorectal cancer (CRC) stem cell model 4088 1499 324 4089 6925 PMC2818872__F8 Ras signaling in early B cell development 8835 9021 7852 PMC2819754__F2 Transcriptional regulation of the differentiation of Th2 cells 324 3565 940 3566 6778 2625 PMC2834552__F11 Schematic diagram of AGE-induced CTGF expression is shown 4087 4088 4092 4089 PMC2835907__F3 Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands 6469 595 1956 3480 1950 2252 2255 3479 367 PMC2836122__F2 Cytokine signaling through the JAK/STAT pathway 3454 3455 3460 3459 3976 3977 8651 6772 6774 9021 PMC2842986__F2 General synthetic route to the racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues (1a–e, g, i–k) is shown in 717 5979 7454 PMC2843167__F7 Summary of the findings presented here 9112 3066 5111 PMC2843172__F8 Schematic drawing summarizing the signaling pathway downstream from CB1 receptors in cerebellar granule cell precursors 2932 1499 595 PMC2847023__F3 Vitamin D3-driven signals for myeloid cell differentiation - Implications for differentiation therapy 7421 10682 929 PMC2856528__F1 The three complement activation pathways, converging to cleave C3 721 716 715 717 PMC2857646__F1 Schematic of the TGFB signaling pathway 4088 4087 4089 PMC2859499__F7 TAK1·TAB2·NLK complex negatively regulating canonical Wnt pathway 23118 51701 51176 PMC2861286__F1 Proposed mechanism for vitamin D’s action on the innate immune system 7097 7096 7421 PMC2867902__F6 A feed forward loop for nutritional regulation of PNPLA3 80339 355 79071 6319 PMC2882188__F3 Complement cascade 10747 710 721 720 718 966 735 1378 PMC2890032__F2 Differential vulnerability of neurons in Huntington's disease: The role of cell type-specific features 4478 2821 627 7054 PMC2890581__F7 Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice 10913 7189 23118 128178 1499 PMC2897911__F1 Induction of Type I Interferons by Bacteria 7099 4615 7098 7097 51284 54106 51311 PMC2902124__F1 TLR signalling 7097 10333 51284 7099 7100 51311 54106 7098 4615 7189 3661 PMC2905406__F10 Illustration of GDNF signaling disruption by coated silver nanoparticles 2668 5979 2534 5266 PMC2910227__F3 Cellular Functions of Transient Receptor Potential channels 3643 695 5728 PMC2912554__F6 Tumor suppressor pathways control Mdm2 function 1021 1019 4087 4088 4193 PMC2913631__F3 Schematic model of crosstalk between PPARG and Wnt-5a signaling in MSC 7474 55636 51701 23118 9869 PMC2917731__F1 Intracellular signaling of FIP1L1/PDGFRA+ (F/P) cells 1232 3568 3717 PMC2919149__F7 Targeting HIF activation pathway for cancer therapy 7381 759 7428 2475 PMC2920679__F1 Regulation of mammalian target of rapamycin (mTOR) signaling functions 7249 7248 6009 55294 PMC2921256__F1 Biology of the von Hippel-Lindau/hypoxia-inducible factor (VHL-HIF) axis in the setting of hypoxia or a mutation or aberration of the VHL gene product 7428 2475 2056 664 7039 1956 PMC2928803__F3 Gene Expression Model for the Preferential Galactose Uptake in Yeast Cells 51083 5091 339855 PMC2932783__F1 Targeting of signaling pathways by arsenic trioxide in chronic lymphocytic leukemia cells 2475 331 5728 PMC2936065__F2 The Lrp5-dependent regulation of bone formation through inhibition of tph1 expression and 5-HT synthesis in enterochromaffin cells 3351 4041 7166 PMC2937518__F4 Overview of predicted carbohydrate uptake and metabolism systems in bifidobacteria 2353 51083 4284 5805 PMC2938833__F3 Pfn gene neighborhood and its interacting pathway 375189 345456 8936 7408 PMC2946881__F1 Regulation of adipogenesis by canonical Wnt signaling cascade 4041 324 1499 PMC2947794__F1 Examination of Association to Autism of Common Genetic Variation in Genes Related to Dopamine 5053 4128 7054 1644 1621 1312 PMC2949723__F3 Eicosanoid signaling pathway from Ingenuity Pathway Analysis software 246 240 241 PMC2962956__F1 Toll-like receptor (TLR) signalling and inhibition by viral proteins 7096 7097 10333 4118 4615 7098 51284 54106 51135 3654 3656 7187 257397 23118 29110 3661 3665 PMC2963106__F2 VHL in clear-cell renal cell carcinoma and its relation to targeted therapy 2475 2056 664 1956 9261 7867 PMC2964117__F2 Small-molecule inhibition of the parasite nicotinate mononucleotide adenylyltransferase (NMNAT) 4827 65220 1362 PMC2964873__F1 The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities 6478 3091 3170 55502 6662 5352 PMC2964899__F1 Schematic representation of the molecular events associated with cellular processing, lipid modification, and secretion of the SHH protein and the autocrine and paracrine actions of mature and secreted SHH protein 6469 55733 6608 5727 PMC2964899__F3 Molecular events associated with the repressive effect induced by PTCH1 receptor on the SMO activity and the activation of the Hh signaling pathway mediated by the SHH protein in the primary cilium 6469 367 6608 PMC2967651__F1 A model for interplay between alloimmunity and autoreactivity in graft rejection 3558 3458 7054 325 PMC2972271__F5 The metabolite NAD+ oscillates in a circadian manner 10135 23411 406 9575 PMC2978223__F1 Daphnia pulex insulin and TOR signalling pathways, adapted from Drosophila melanogaster 7248 7249 5728 PMC2989404__F1 Eighteen Insulin-like Growth Factor (IGF) pathway genes, circulating levels of IGF-1 and its binding protein (IGFBP-3), and risk of prostate and breast cancer 2691 6750 2692 2690 3630 3482 PMC2994209__F1 HER receptors and their ligands 1950 7039 10718 3084 145957 9542 1839 374 2069 1956 PMC2994272__F8 Carnosol in human prostate cancer PC3 cell line 5728 7249 7248 2475 PMC3001953__F2 EGFR-mutated lung cancer: a paradigm of molecular oncology 2885 2475 595 1848 1850 1843 1846 PMC3004666__F1 Cetuximab in the treatment of colorectal cancer 367 1950 3480 5728 572 2475 PMC3006043__F3 Colorectal Cancer Molecular Biology Moves Into Clinical Practice 1956 2885 5290 3845 5728 673 PMC3020075__F1 GPC5 Gene and Its Related Pathways in Lung Cancer 2262 4040 4041 2885 51684 324 1499 PMC3021097__F2 Functional significance of itpkc_3 on ITPKC mRNA and Ca2+/NFAT pathway 324 2638 80271 759 PMC3025834__F1 Schematic representation of xylose metabolic pathway in metabolically engineered S 6120 7498 7504 PMC3026934__F2 Signaling pathway induced by Dectin-1 6714 6850 64170 10892 8915 PMC3035094__F6 Cic regulatory elements mediate Torso and EGFR responses 23152 7038 1956 PMC3043094__F2 Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach 4286 1499 7306 1638 PMC3055988__F2 Further implications of G-/GM-CSF-induced JAK-STAT signaling in peripheral sensory neurons 7442 6336 3751 3776 6774 PMC3057454__F2 Autophagy in Immunity and Cell-Autonomous Defense Against Intracellular Microbes 2475 55062 26100 8408 PMC3063605__F1 Simplified cartoon of PRR signaling in epithelial cells showing only the canonical pathway of NFKB activation and some of the key receptors, adaptors, and kinases involved 7096 7097 10333 7099 54106 7100 1611 4615 PMC3064322__F5 Model showing the regulation of PPARA by metabolism and PAR bZip transcription factors 2194 4023 5465 PMC3064905__F3a Genomic revelations of a mutualism: the pea aphid and its obligate bacterial symbiont 367 7067 7068 PMC3065553__F5 Metabolic pathway for pitavastatin 1559 54658 54659 7364 1565 1576 PMC3073278__F1 Tumor-induced DSB formation in vivo 6347 6741 3014 PMC3073781__F6 Schematic overview of the MDM2 and p53 signalling pathway 4609 4193 581 PMC3074690__F1 The current model of the blood coagulation cascade 7035 387758 9015 PMC3075259__F4 Data Integration Workflow for Search of Disease Driving Genes and Genetic Variants 1029 4548 4193 4194 7157 891 PMC3079783__F1 Leptin Signaling in Intestinal Epithelium Mediates Resistance to Enteric Infection by Entamoeba histolytica 3717 572 581 9021 PMC3079800__F1 Parenteral Nutrition Impairs Lymphotoxin B Receptor Signaling via NF- KB 3603 4055 5971 8174 6363 6364 6370 3586 PMC3080176__F2 Diagrammatic representation of the top three canonical signaling pathways, proposed by the Ingenuity Pathways Analysis program, associated with differentially expressed genes in the microarray dataset 472 5426 7273 PMC3080795__F2 Scheme for CCM including main pathways - glycolysis/gluconeogenesis, penthaphosphate pathway, citrate cycle, overflow pathway 51430 4118 22934 11113 PMC3091694__F6 Toll-like Receptor signalling canonical pathway 3929 929 114609 3550 PMC3093412__F1 Viperin Links Lipid Bodies To Immune Defense 54106 51284 4615 3665 51135 3654 7189 PMC3096731__F1 Eph receptor and mTOR pathway crosstalk: implications for cancer 5728 7249 7248 6009 2475 PMC3099592__F2 Activation of mast cells initiates a cascade of events resulting in Th2 polarization and both positive and negative feedback regulatory loops 6778 3717 3718 PMC3100722__F1 The neuroendocrine (a), limbic (b), and brainstem (c) inter-related, stress-activated corticotropin releasing hormone (CRH) loops 759 1636 761 4922 PMC3101043__F2 Endogenous and exogenous regulators of TLR activation 114609 4615 54472 7189 29110 PMC3101870__F1 Three levels of regulation of the IGF-IR pathwayand its components 2691 3480 3482 2885 5728 572 2475 PMC3104724__F2 This figure outlines the role of KLF10 protein as a target and as a regulator of the TGFBeta-Smad 2,3 signaling pathway 4087 4088 4092 4089 7071 PMC3109408__F2 Simplified diagram of Kynurenine pathway: during neuroinflammation, 95% of the dietary tryptophan is metabolized along the KP within the brain 8564 130013 23475 PMC3111844__F1 Overview of Androgen Metabolism Pathway Genes Considered, Including Candidate Genes and Genetic Variants Studied 6716 367 57530 2099 PMC3116598__F1 p21-activated kinases in Erbb2-positive breast cancer 2064 2475 4609 PMC3122316__F1 F igure 1.— 7808 471 158 8833 PMC3128772__F6 Cell signaling between rNSCs and hMSCs in coculture 182 7040 4854 23462 2670 PMC3132106__F1 Summary of the extracellular interactions between Wnts, Wnt receptors and Wnt regulatory proteins 6259 4593 1499 PMC3133356__F7 Model showing the role for Bmi1 in the DNA damage response pathway 545 6741 472 3014 9025 672 648 PMC3137012__F8 Hypothesis of insulin signaling pathways associated with the regulation of CIDEA and CIDEC expression in human adipocytes 207 208 1149 63924 PMC3142564__F3a Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer 2064 1956 2475 PMC3142910__F5 Schematic representation showing proposed role of TMPRSS6 regulation by the BMP6-SMAD signaling pathway and iron via ID1 654 3077 148738 164656 4092 4090 4086 4089 3397 PMC3154715__F3 Working model of relaxin sustained-vasodilatory response 59350 4280 7077 5228 PMC3155407__F1 Murine model of the multiple actions to suppress immune surveillance of exosomes released from neoplastic cells 3718 929 920 50943 PMC3159004__F2 TLR-independent innate immune responses 717 3661 4772 PMC3159179__F4 Methionine-Hcy metabolism 4397 4524 875 PMC3160828__F1 More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases 6772 2625 3595 864 6775 8320 3594 920 PMC3162305__F4 Oncostatin M signaling pathway 5008 9180 4117 2885 2002 2034 5328 7078 4502 PMC3167888__F6 Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages 472 596 581 317 PMC3174390__F1 TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation 3553 4092 4087 4088 4089 PMC3175563__F6 Proposed mechanism of mechanical stress–induced activation of EGFR pathway in murine tracheal epithelial cells 1956 1950 1839 7039 PMC3176402__F4 Zn and Zn transporters are indispensable for FcERI-mediated mast cell activation 2534 9846 387 PMC3178285__F5 Proposed signaling of TNFA− and leptin-induced EL upregulation in primary placental ECs 3953 8717 7186 9388 8567 PMC3179938__F3 Top IPA generated network 3820 11027 10464 79759 345611 958 239 246 123 122809 PMC3184062__F9 Scheme for poly(I:C)-induced apoptotic signaling pathway in high TLR3-expressing NB cells (left panel), but not low TLR3-expressing NB cells (right panel) 7098 3240 3661 PMC3186046__F1 S1P receptor subtype-specific heterotrimeric G protein coupling and intracellular signaling mechanisms 1901 9294 1903 6010 5728 PMC3187860__F1 Brain Arteriovenous Malformation Pathogenesis: A Response-to-Injury Paradigm 2022 2050 4087 4088 PMC3188749__F3 Simplified schematic presentation of the transcriptional hierarchy of essential factors and signaling pathways during endocrine specification of the pancreatic endoderm 3651 5078 5629 PMC3189169__F1 Toll-like receptor (TLR) and type I interferon (IFN) signaling pathways 7098 54106 51311 51284 6772 10379 6773 4615 7297 29 3445 7187 3716 29110 3661 PMC3191051__F9 Model for TGFB1-mediated signaling to the miR143/145 regulatory region 7040 4087 4089 93649 6722 PMC3193242__F7 The cross-talk between IKK family members in the MyD88 signaling pathway 7189 23118 257397 10010 29110 PMC3196116__F10 Proposed model shows the requirement of the IL-4RAlpha-Jak2-mediated signaling pathway for IL-13-induced M2 gene expression in human monocytes/macrophages 3717 6772 3055 6774 948 PMC3198893__F5 One of the networks of genes strongly induced in dendritic cells but less so, unchanged, or suppressed in macrophages 4158 2492 7186 3172 5514 333926 6047 2130 PMC3199809__F1 The TGFB signaling pathway 4087 4088 4089 PMC3208682__F1 Expression patterns of the TLR signaling pathway in CLL 929 59307 114609 8767 353376 695 148022 4615 54472 51135 7189 3656 3654 51295 23118 10454 6885 5609 4214 1147 3551 6416 9448 5606 4792 4790 5970 29110 3439 941 3661 3725 2353 7124 3458 3586 3592 PMC3216694__F1 Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors 4018 6010 5091 6722 759 4026 4099 PMC3217176__F3 Targeting the PI3K/AKT/mTOR pathway 572 2932 595 PMC3219092__F3 Nox regulation of the PI3K/AKT pathway 5728 6714 2308 572 PMC3220493__F6 Schematic model in which FGF2 stimulation of osteoblast differentiation is partially through modulation of the Wnt/Beta-catenin pathway 2247 7480 4040 4041 2932 1499 860 468 PMC3226315__F1 Recent focus in JMML has concentrated on using the information gained from knowledge of these molecular defects in order to design targeted drug therapy 2885 4763 3717 PMC3232381__F1 Tumour necrosis factor receptor 1 (TNFR1) and its signalling pathways 8717 7186 8772 PMC3236573__F3 Ovarian cancer ascites-mediated protection from TRAIL-induced apoptosis 8772 581 637 PMC3243479__F3 Fatty acid Beta-oxidation, TG synthesis, and phospholipid biosynthesis pathways 8567 1756 5662 780904 10400 PMC3250080__F1 CR-associated signaling and some of its key players 2690 3479 3480 3667 6009 PMC3250173__F7 TLR3/TLR4-mediated signaling pathways 7099 114609 4118 7098 4615 3661 PMC3250521__F4 Inhibition of isoprenoid biosynthetic pathway by ATST [modified from Holstein et al 3652 388 5906 387 PMC3251532__F5 The lymphocte-specific gene (A) or urine peptide (B) markers 7349 5790 22808 4363 5566 619410 3052 894 4683 51427 PMC3254670__F1 Metabolic connections during apoptotic cell engulfment 7351 10461 948 558 19 713 4240 PMC3255869__F1 TLR4 signaling pathway 7099 929 114609 4615 PMC3258305__F2 The Long History of Iron in the Universe and in Health and Disease 7018 55240 22 PMC3267756__F9 Coxiella burnetii Induces Apoptosis during Early Stage Infection via a Caspase-Independent Pathway in Human Monocytic THP-1 Cells 8717 8772 581 PMC3268389__F1 Pathways and compartmentation of FA supply for TAG synthesis in plants 847 5091 355 PMC3268941__F1 Canonical Wnt/Beta-catenin and non-canonical Wnt signaling pathways 1499 4040 4041 4920 5879 387 9475 PMC3275500__F1 The Ras-MAPK and TGFB pathways 2885 4087 4088 4089 5494 PMC3275780__F2 T cell activation 324 920 6714 7535 PMC3276472__F1 Schematic in vivo biosynthetic pathway from 18:3n3 and 18:2n6 mediated by ELOVL4 and other ELOVL family proteins 54898 60481 83401 64834 6785 PMC3281554__F2 Possible mechanisms of regulation of DP thymocytes by multiple factors 1960 1499 3399 6097 PMC3281607__F2 Antioxidant roles of Prx I, Prx III, and Srx in ethanol-fed mouse liver 1571 57716 9817 PMC3281649__F9 Proposed model for the inhibition of Notch1 signaling pathway by Fe65 4851 83737 3280 388585 PMC3285398__F1 Toll-like Receptors (TLRs) recognize specialized structural motifs on the microbes known as pathogen-associated molecular patterns (PAMPs) 7099 7096 7097 10333 7100 4615 114609 51135 3654 54106 51284 51311 7098 7189 3661 29110 PMC3287202__F6 Overview of pre-miRNA processing 29102 23405 79727 27161 PMC3288148__F1 Three pathways contribute to cellular BH4 levels, the synthesis pathway, the salvage pathway and the recycling pathway 2643 367 6697 1719 PMC3288319__F4 Phytoestrogens on ECs and VSMCs 2638 387 7834 PMC3288605__F2 Pathway of formation and catabolism of HDL particles 19 5360 4023 3931 1071 PMC3291304__F1 Protein quality control systems are potential targets for mechanism-based treatments of demyelinating Charcot-Marie-Tooth disease (CMT) 4359 5376 9097 PMC3303469__F1 Hypoxia inducible factor (HIF) pathway 3091 7428 405 2033 PMC3306972__F1 ABPP processing, the adaptor proteins interacting with its intracellular domain and the pathway leading to ERK1/2 activation 351 2885 8650 PMC3309942__F1 Interaction motifs and domains of RANKL signal intermediaries 7189 5763 8161 PMC3315209__F6 Speculative model for the role of the Hippo pathway in germ cell tumorigenesis and reprogramming 373863 442917 26524 PMC3316754__F5 Ingenuity pathway analysis was used to create a network of biologically relevant genes regulated in response to diet for comparisons control versus diet A, control versus diet B, and diet C versus diet B 5328 7067 4609 10075 PMC3318742__F8 Model of how RACK1 mediates activation of SHH/GLI signaling in NSCLC Cells 6469 6608 2735 PMC3319201__F3 Primary therapeutic targets in the Ras downstream signaling pathway 4763 4771 5728 6010 2475 PMC3323190__F7 Summary of the effects of leptin in the hypothalamus of control (A) and ob/ob mice (B), as revealed by Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) and 13C High-Resolution-Magic Angle Spinning (HR-MAS) 4852 181 23237 PMC3328839__F6 Proposed pathway 2475 6786 84876 1977 7018 PMC3341711__F1 TGFB/Smad canonical signaling pathway 4087 4088 4089 7018 7046 PMC3343200__F5 IL-6 contributes to a positive feedback cycle of growth and invasion between CAFs (myofibroblasts) and its underlying tumor (afferent pathway) and between invading tumor and the recruitment of fibroblasts to myofibroblasts (efferent pathway) 6774 1950 4854 PMC3344904__F1 High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery 7297 3454 3716 3455 6773 6772 10379 PMC3348964__F1 Metabolic pathway for disulfiram in humans 1431 100187761 57762 4342 7454 1576 PMC3349963__F1 Canonical and non-canonical IL-13 signaling in cells 7297 3597 6774 PMC3350847__F2 Canonical Wnt pathway 1499 324 2932 PMC3351275__F3 Negative feedback and adaptive resistance to the targeted therapy of cancer 367 5728 2475 PMC3353888__F1 Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis 5443 7054 1644 1621 1312 5409 2776 2767 148 147 PMC3365812__F3 Hh signaling pathway and their inhibitors 6608 27148 51684 4609 PMC3372214__F1 Simplified schematic presentation of HCV genotype 2a-mediated blocking of the insulin signaling pathway 3667 7249 6009 PMC3372922__F2 Action of TIEG in the TGFBeta-Smad signaling pathway 4089 4092 4087 PMC3376383__F2 Growth Control by Committee – Intercellular Junctions, Cell Polarity, and the Cytoskeleton Regulate Hippo Signaling 92359 64398 10207 154796 PMC3380363__F1 Oncogenic signaling pathways regulated by NO and PP2A 1956 6714 1499 PMC3380732__F7 Analysis of the cell cycle pathway 7030 4005 4088 6721 2005 5078 4782 1030 6720 5465 6778 1019 4781 PMC3381230__F2 Major mechanisms of immune modulation by tolerogenic DCs 3586 85480 6775 941 958 942 PMC338270__F1 Modification pathway of proteins for isoprenylation/methylation and effects of inhibitors of each enzymatic step 9986 387 23463 PMC3384069__F1 Wnt/Beta-catenin signaling pathway 2932 324 1499 PMC3384423__F1 MTOR signaling pathway 4763 5728 7249 7248 6009 5901 253260 2475 64798 PMC3396054__F3 TGFB activates Smad 2/3 and Smad1 pathway 4087 4088 4086 1490 PMC3397482__F4 Cytoscape is an open-source bioinformatics software platform for visualizing molecular interaction networks and integrating these networks with other state data 405 3796 367 10743 PMC3397862__F7 Schematic representation for the up-regulating mechanism of NSC proliferation by modulating Notch signaling with Lewis X-containing glycans in NSCs 5080 10690 8650 4851 388585 PMC3399380__F2 IGF-IR signaling pathway 2885 3667 2475 PMC3403823__F1 TLR-induced corneal inflammation 7097 7099 54106 7098 4615 7189 3661 PMC3404876__F2 Identification of novel metastasis suppressor signaling pathways for breast cancer 8091 571 7852 4312 PMC3406594__F8 Schematic model showing role of AMPKA1 as an upstream kinase of TAK1 in TLR4-mediated signaling pathway 7099 7189 23118 257397 7124 4615 3654 4118 PMC3408695__F1 Part of the metabolic pathway of estradiol and the role of various enzymes involved: Estradiol is metabolized into 2-hydroxyestradiol (2-OHE2) and 4-hdroxyestradiol (4-OHE2) by CYP1A1 and CYP1B1 respectively 1545 1543 1312 1728 PMC3410756__F1 Folate mediated one-carbon cycle 4524 4397 4552 7298 1719 PMC3411424__F4 AlzPathway on Payao system 8205 1311 6476 PMC3412276__F1 Mannose metabolism in Trypanosoma brucei 2582 101448070 2821 PMC3416961__F1 Simplified diagram depicting Ras signaling and crosstalk with PI3 kinase- Akt pathway in leukemia 2322 5159 613 2475 PMC3423339__F7 BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II 3399 3397 3516 PMC3423541__F2 Biological targets under investigation for treatment of SLE 367 940 6850 2475 958 3662 29851 PMC3427269__F1 AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway 3845 3569 3716 6714 6774 PMC3429478__F1 Development of Quinoxaline 1, 4-Dioxides Resistance in Escherichia coli and Molecular Change under Resistance Selection 7038 2242 4553 PMC3443258__F6a An inventory of peroxisomal proteins and pathways in Drosophila melanogaster 95 8443 8540 PMC3444139__F3 NFKB signaling pathway in ATL 4055 958 5971 5970 PMC3446326__F1 Alterations in the FGFR signalling pathway that influence breast cancer 2263 2260 2264 PMC3446495__F1 Impaired immune system in patients with systemic lupus erythematosus (SLE) 3684 3123 3586 324 640 4067 25780 4688 6775 26191 7292 5132 7128 3663 10318 3665 7332 3394 64135 PMC3458056__F5 Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas 5594 5595 7124 7015 3569 3488 1460 4609 3275 367 22808 5970 7157 4793 11335 PMC3460238__F1b Central role of AP convertase in complement activation 4179 718 1356 1604 4155 966 PMC34619__F2 Signaling to eukaryotic translation initiation and elongation factors 2475 29904 1938 1975 PMC3461905__F2 Molecular pathogenesis of mantle cell lymphoma 4851 613 102 4067 2534 4193 6850 695 2932 596 581 2475 PMC3464048__F2 Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets 6714 6774 4609 PMC3466807__F1 BOLERO-2 trial: the addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer 2475 5728 7248 7249 6009 PMC3467778__F3 Skewed Th17/Treg cell differentiation in patients with BD, a hypothesis 4087 4088 6774 50943 6097 PMC3469587__F7 SP-A-regulated signaling pathways in human macrophages 7099 3654 7189 7124 PMC3469610__F6 Schematic diagram of proposed molecular mechanism of p27 downregulation in Fen-induced cell growth in fibroids 3479 3480 1017 PMC3470040__F1 MYCN-dependent apoptosis and the MDM2–p53 pathway 648 4613 4193 28996 3159 PMC3471227__F1 Hh pathway activation, inhibition, and mechanisms of drug resistance 5727 6608 51684 2735 2475 2736 595 PMC3476325__F9 Proposed model for how CCL2 signaling through CCR2 signaling regulates survival and motility of breast cancer cells 6347 729230 4088 387 PMC3479242__F4 Optimizing the balance between host and environmental survival skills: lessons learned from Listeria monocytogenes 4352 4351 5805 718 PMC3481480__F11 Pathway Diagram of Oxidative Stress along with PI3k/Akt 5728 472 571 9817 4094 4193 2932 572 PMC3484431__F9 Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma 4318 6469 2735 6608 PMC3493902__F8 The diagram illustrates the possible mechanism of tumor cells-secreted CCN1 in regulation of pancreatic carcinogenesis through the regulation of SHh signaling 10983 6469 6608 2735 PMC3498840__F1 TLR signaling overview: the TLR family can be subdivided into two categories 7099 7100 7097 10333 7096 4615 114609 7098 51311 51284 54106 3661 3665 PMC3499368__F1 Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors 5640 367 907 PMC3509372__F1 Treg regulatory pathways 1493 942 941 29851 50943 PMC3512410__F2 Scheme depicting the different outcomes caused by the presence of progerin and prelamin in cells 1499 5928 860 472 545 PMC3515033__F5 Cytokine intracellular signaling pathways 3553 3458 3554 7186 8717 4615 8772 6772 PMC3516044__F3 Changes in the Plasmodium falciparum redox flux network after MB drug action.Notes: Results incorporating the transcription data and experimental mRNA expression data nine hours after incubation with methylene blue are shown 3931 100187761 5979 6651 445582 PMC3521191__F1 Biological pathways targeted for therapy in renal cell carcinoma based on a knowledge of the underlying genetic changes and downstream biological consequences 7428 5728 595 PMC3521201__F1 Central carbon metabolism pathways in E 85569 3250 11113 PMC3523822__F1 Biosynthetic pathway of diphthamide in eukaryotes 1801 1802 285381 51611 89978 92715 PMC3527145__F1 The left-right asymmetry pathway 4838 5308 7044 PMC3533285__F11 SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation 2874 7291 2920 PMC3539662__F1 Kaposi sarcoma-associated herpesvirus K1 activates PI3K/AKT/mTOR signaling thereby activating protein synthesis and survival pathways, while inhibiting apoptotic pathways 2932 6850 4067 2475 PMC3540836__F1 Experimentally supported and inferred factors of Drosophila triacylglycerol synthesis and mobilization at lipid storage droplets 5091 5183 123 10554 7038 5346 PMC3541196__F3 Dysregulation of the cell cycle pathway during tumor progression 1869 5933 1029 902 595 894 8900 896 1031 1032 891 898 993 7027 1027 1017 1019 1030 5925 1021 1022 1026 PMC3545297__F1 Energy metabolism in a typical mammalian cell 51083 2821 355 PMC3547636__F2 G Protein-coupled Receptor FPR1 as a Pharmacologic Target in Inflammation and Human Glioblastoma 301 1956 2357 6714 3576 6774 PMC3549535__F3 Innate immune stimulation by LPS positively impacts T cell priming 7099 325 941 942 4615 7124 PMC355855__F10 Models for repression of TGFB signaling by the Smurf-Smad7 complex and reactivation of TGFB signaling by the Jab1/CSN5-Smad7 complex 4087 4088 64750 57154 4092 PMC3558831__F6 PIAs recapitulate the activity of two tumor suppressors that converge on mTOR 5728 7249 2475 PMC3571454__F10 Models for intrinsic signaling by BST2 and for BST2 as a virus sensor 684 10454 23118 4615 7186 PMC3574928__F1 De novo purine biosynthetic pathway in humans 2618 5471 10606 7808 471 435 PMC3575604__F1 Evolution and impact of subclonal mutations in chronic lymphocytic leukemia 6420 5447 472 PMC3576812__F1 The hedgehog’s tale: developing strategies for targeting cancer 6608 51684 5727 PMC3578480__F2 Molecular pathways associated with CPPs 999 7291 6598 4854 PMC3579383__F1 Myelin-derived neurite growth inhibitors, their receptors, and intracellular signaling pathway 4099 84894 387 PMC3579397__F1 Sulfide production 875 27232 6821 PMC3580410__F4 Functional interaction sub-network constructed by using module 2 genes 9183 57405 79172 699 701 6396 64946 1062 10112 2491 55839 6795 54888 55139 64151 9918 PMC3584681__F2 Pattern-recognition receptors (PRRs) and signaling pathways that lead to differentiation of antifungal T helper (Th) cells 4615 4118 8915 85451 64170 3661 114548 5971 3553 7054 PMC3587611__F8 Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo 7473 4041 23399 1499 22943 5225 PMC3589096__F2 SREBP activation and input from mTORC1 signalling 6720 6721 22937 PMC3597666__F5 Representation of the top canonical pathway ‘interferon signalling’ detected when simultaneously analysing the mRNA and miRNA data sets with IPA 3458 3717 3716 6772 8554 8519 3659 10379 5696 581 PMC3606632__F6 MTOR signaling pathway in KEGG pathway analysis 2475 253260 1975 6009 7249 1977 673 PMC3613937__F1 Desmoglein-1, differentiation, and disease 1828 1950 2885 8036 55914 4014 1823 PMC3617635__F6 CLL-induced Rho GTPase signaling defects in T cells that suppress LFA-1 activation signaling and migration and how this is reversible with lenalidomide 3383 387 5879 998 PMC3619152__F10 Proposed pathway showing increased Nox4 expression and H2O2 levels in PPHN PA, leading to a decreased ecSOD activity and vasoconstriction, and increased NFKB and cyclin D1 leading to pulmonary vascular remodeling 50507 7054 595 PMC3627370__F1 NAMPT in mammalian NAD metabolism 10135 203447 952 PMC3628101__F1 The novel NRP2A6B1-FAK-RAS-GLI1 axis involved in the regulation of tumour initiating cells in breast cancer 2735 8828 648 PMC3632588__F6 Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta 8651 3716 6772 PMC3634196__F7 Summary diagram of the proposed mechanisms underlying CA3 hypersensitivity, Alzheimer’s disease protein induction, neuronal death and behavioural deficits following cerebral ischaemia in rats with LTED 761 3725 23621 PMC3634910__F2 Nutrient Signaling to mTOR and Cell Growth 7249 51256 7248 6009 2475 PMC3636031__F9 Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague 8772 7189 637 PMC3643422__F1 Illustration showing the overall sex hormone metabolic pathway and subpathways 6770 5241 367 6462 2100 1312 PMC3646329__F2 HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer 1956 3845 5728 673 7249 7248 PMC3646763__F7 Beyond the Binding Site: In Vivo Identification of tbx2, smarca5 and wnt5b as Molecular Targets of CNBP during Embryonic Development 81029 7555 6949 8467 1958 10397 PMC3664143__F1 A Novel High-Throughput 1536-well Notch1 Gamma-Secretase AlphaLISA Assay 4155 102 6868 PMC3665639__F2 Cell cycle regulation of Golgi membrane dynamics 4905 6811 100170220 PMC3669920__F1 Schematic of neuregulin-ERBB4 signaling showing the roles of the products of the selected genes 2066 23621 1950 3084 10718 PMC3670113__F1 Role of SHIP1 in bone biology 3398 8821 5266 7398 5728 2932 1499 PMC3670237__F2 STAT3 regulation of and by microRNAs in development and disease 3716 3717 6774 6714 3727 PMC3670280__F3 STAT1 as a central mediator of IFNG and TLR4 signal integration in vascular dysfunction 7099 3716 7297 3659 4615 3394 3661 PMC3671665__F1 Targeting the Sonic hedgehog signaling pathway by compounds and derivatives from natural products 6469 5727 6608 2736 2735 PMC3676786__F1 Representative anti-angiogenic drugs and their targets in the angiogenic pathway 7422 2322 3815 5894 PMC3677821__F2 Schematic showing some major pathways implicated in cancer progression using Drosophila studies 1311 23513 6714 1445 4609 PMC3678031__F2 The amygdala and medial prefrontal cortex: partners in the fear circuit 1431 1178 5091 PMC3678388__F3 ATR recruitment to some DNA base lesions proceeds through a mismatch repair-dependent mechanism.Mismatch repair proteins may contribute directly and indirectly to ATR recognition of some times of DNA damage 545 84126 11073 PMC3684083__F4 EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets 1950 7039 2475 PMC3684179__F1 Cyclin D1 stability is regulated by ubiquitination-dependent proteasomal degradation 26259 595 9099 PMC3686618__F6 Main signaling pathways supposed to be activated in MEC exposed to either E 4049 7097 7099 4615 3661 3627 6364 3576 PMC3686733__F2 Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets 85569 443 3939 PMC3694595__F1 IL-33: A Novel Danger Signal System in Atopic Dermatitis 64806 85480 90865 PMC3695880__F1 The wiring diagram of the UPR model 22926 83939 468 51562 PMC3696739__F3 Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development 4488 657 1499 4313 367 PMC3698976__F2 Methionine metabolism: transmethylation pathway 635 4397 4524 191 PMC3711797__F4 Mathematical model of type I IFN signaling pathway 8651 6772 3659 PMC3713495__F4 EZH2 promotes E2F driven SCLC tumorigenesis through modulation of apoptosis and cell cycle regulation 5925 1870 1871 1869 1719 5111 572 2146 PMC3715061__F1 Hedgehog signaling, vismodegib action, and acquired resistance 6608 5727 51684 2735 8643 2737 2736 PMC3718318__F16 ROS in endoplasmic reticulum (ER) stress-induced cell death 355 948 4018 PMC3723115__F2 Canonical TGFB signaling within distinct cell types located in tumor microenvironments 4089 4090 4086 4087 4088 PMC3724057__F7 MOMA analysis identifies double-gene knockouts in primary metabolism that funnel carbon toward DHA 11113 259266 4118 PMC3726398__F2 Reconstructing the interactions among different modules of the MAPK pathway 1950 5548 126669 PMC3736540__F1 Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour 7099 4615 3661 PMC3736728__F2 Folate, Alcohol, and Liver Disease 635 4397 875 4524 PMC3741439__F1 The catecholamine biosynthetic pathway 5053 7054 1644 5409 PMC3752772__F2 NFKB activation pathways triggered by TNF family signaling 7124 5971 5970 PMC3755409__F6 Scheme of the andrographolide regulatory pathway 100187761 3791 8829 595 PMC3757225__F7 Mechanistic model of strain-induced fetal type II cell differentiation via integrin-TACE pathway 1839 7039 1956 6868 PMC3757712__F3 Crosstalk between the Nrf2 and NFKB pathways 8841 9817 4094 PMC3759481__F1 Simplified schematic shows the major intracellular signal transduction pathways that regulate the epithelial-to-mesenchymal transition (EMT) process in fibrotic kidneys 3611 1499 4040 4041 2932 100379198 324 PMC3762088__F2 Regulation of autophagy by oncogenes and tumor suppressors 5728 596 7249 7248 PMC3762715__F5 Transcriptome Profiling Reveals Th17-Like Immune Responses Induced in Zebrafish Bath-Vaccinated with a Live Attenuated Vibrio anguillarum 387 324 2932 1499 3725 PMC3769666__F1 Extrinsic and intrinsic apoptotic pathways 637 8717 581 331 PMC3771080__F1 Pathway analysis depicting cytokine and cytokine receptor interactions relative to position in the cellular environment 3586 3565 3552 7124 3458 3557 3600 7040 3569 8797 7132 3460 7046 3601 3455 3575 PMC3772385__F8 Model describing the relationship of osteoblast-produced Bmp2 and connections to VegfA production and increased microvascularization that serves as a major niche for mesenchymal stem cells 9242 650 1277 7422 PMC3772387__F8 Recruitment of FLNa, IQGAP1 and RacGAP1 to active B1 integrin regulates Rac1 activity 2316 8826 29127 5879 PMC3775578__F1 Novel investigational drugs for basal cell carcinoma 51684 6608 5727 PMC3781192__F1 Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults 6573 4548 4524 875 PMC3789714__F1 Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens 2475 7249 7248 8408 PMC3795344__F3 Schematic diagram illustrating a proposal for the involvement of Cdx2 during progression of cancers through the serrated pathway 673 1029 1045 PMC3795378__F2 Tumor (SVZ) micro-environment 6387 2668 627 655 6469 PMC3797025__F7 Schematic model of adaptive primary resistant responses by tumors to anti–IGF-1R monoclonal antibodies (mAbs) 3480 1956 6714 2475 PMC3808218__F1 PI3K/Akt/mTOR pathway 3667 7249 7248 2475 253260 6009 1977 PMC3808235__F1 Pathway-guided treatment in prostate cancer 5728 2475 367 6790 PMC3809585__F3 TAM-regulated cycle of inflammation in dendritic cells 7099 7098 7187 7189 558 2621 PMC3821792__F2 TLR-4 signaling pathway.Notes: TLR-4/MD-2 complex homodimerization activates the MyD88-dependent pathway and TRIF-dependent pathway 4615 51135 3656 3654 7187 7189 3661 3458 PMC3821857__F7 DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma 1950 1956 5921 9046 3845 PMC3827118__F2 Hh signaling in mammals 6608 5727 51684 55733 PMC3827721__F4 In silico method for modelling metabolism and gene product expression at genome scale 3098 2444 2875 273 PMC3828572__F8 mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions 3845 5728 2475 PMC3829165__F9 Schematic illustrating the signaling pathways for TGFB1-induced down-regulation of VE-cadherin and the inhibition of cell invasion in human trophoblast cells 4087 4088 4089 1003 PMC3829661__F2 Schematic overview ofP 5091 100379198 5662 780904 PMC3838179__F11 Proposed model for the NOTCH-ROCK pathway and its biological significance 4851 6093 6010 PMC3840450__F1 The main actors intervening in the canonical and noncanonical NFKB activation pathways 958 5970 5971 PMC3847559__F5 Combining DC vaccination with immune checkpoint blockade 940 941 942 PMC3849893__F1 Interferon signaling pathway 3716 7297 6773 10379 PMC3851442__F2 Transposable elements and their potential role in complex lung disorder 324 7054 260431 PMC3851951__F4 Microbiota impact on the epigenetic regulation of colorectal cancer 4049 920 7078 864 PMC3851989__F2 The second module identified by iMCMC and the corresponding known pathway in the GBM data 1030 1019 6302 PMC3851989__F4 Identification of mutated core cancer modules by integrating somatic mutation, copy number variation, and gene expression data 4609 898 5893 PMC3857020__F10 Proposed functions of Spry1 and Spry2 in regulation of eyelid closure 2255 2263 10252 10253 894 595 6469 PMC3857727__F1 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors 349565 64802 23057 PMC3860520__F3 Toll-like receptor (TLR)-4 signaling pathway in alcoholic liver disease 4615 3654 51135 7187 7189 29110 3661 114609 PMC3865699__F1 Major mechanisms linking obesity with impaired muscle regeneration 3553 2475 5111 PMC3871277__F1 Panitumumab and epidermal growth factor receptor (EGFR) signaling pathway 1956 126669 2885 2475 PMC3875780__F3 Human intestinal innate myeloid cells 7097 7100 7099 929 3662 PMC3875959__F3 Proposed model for the role of lncRNAs in RB pathway 595 1021 100033819 283120 PMC3876077__F1 Schematic overview of the transforming growth factor (TGF)B signaling pathway 4089 4092 6497 PMC3877685__F2 Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks 673 717 718 1499 727 595 PMC3879708__F2 Upstream nutrient signaling to mTORC1 and AMPK 7249 7248 6009 664 PMC3894232__F2 JAK2-STAT5B pathway and osteoblast differentiation 3479 2690 3717 6777 PMC3902114__F1 Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression 10401 367 6347 6351 729230 PMC3906547__F1 Reverse cholesterol transport pathway delivers free cholesterol from macrophages or other cells to the liver or intestine for excretion 3949 3931 5360 1071 53369 PMC3911547__F12 Schematic diagram depicting the diverse outcomes of KSHV-induced 5LO and LTB4 in ECs and the consequences and roles of KSHV in viral pathogenesis 56413 1969 6714 PMC3923158__F2 Components that determine the establishment and tolerance-inducing capacity of tolerogenic effector DCs 941 942 355 6774 7124 7432 PMC3924254__F7 A6 integrin is the upstream regulator of the IGF-1R signaling pathway that enables low levels of caspase-3 activation to signal lens epithelial cell differentiation initiation 3480 6714 100420342 331 PMC3925803__F5 Model showing elevated calcium and/or phosphate up-regulate HGF secretion and c-Met activation in conjunction with activation of the PI3K/Akt signalling pathway, leading to SMC mineralisation, which can be inhibited by AdNK4 treatment 3082 4854 650 860 PMC3926866__F1 Diagram of the steroid hormone biosynthetic pathway in the human adrenal cortex 1586 1583 3284 1589 1584 1585 PMC3926884__F1 Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab 3845 374 3565 1956 126669 2885 2475 PMC3928643__F3 IFNA/B and IL-4 centred pathway analysis 2695 3458 3565 3561 958 6348 PMC3928701__F1 Normal signaling pathways and alterations in aged DCs in response to lipopolysaccharide (LPS)/bacteria (A), and in response to self antigen (DNA) 4615 3661 3569 PMC3931971__F1 Simplified schematic of common mutations in the Hedgehog signaling pathway leading to basal cell carcinoma from pathway activation (a), and therapeutic targets of this pathway (b) 5727 6608 6469 PMC3933348__F1 Overview of tamoxifen metabolism pathway and the main enzymes involved 1565 1559 1555 1557 PMC3934928__F2 Cell biological view of Toll-like receptor function: regulation through compartmentalization 7099 7100 929 4615 51284 54106 114609 7187 PMC3945336__F1 Mannose and glucose metabolic pathway 4351 5373 101448070 PMC3946526__F6 The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer 64220 9227 1592 56603 PMC3956502__F4 Mechanisms underlying the inhibition of interferon signaling by viruses 3716 7297 3717 6773 PMC3961843__F1 Selected glucose metabolic genes and their potential roles in tumor development 3099 2673 2645 2821 8473 PMC3962112__F1 Biosensor-derived promoters upstream of modules B and C to control the expression of fadD and atfA, and the ethanol biosynthetic pathway (adhB and pdc), respectively 5132 355 8772 PMC3965671__F5 The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs and Skin 196 2638 64806 3603 6364 6356 7908 6369 10344 6352 6354 2919 2920 3576 PMC3965671__F6 Mechanisms by which Th17 and Th22 pathways contribute to psoriasis and atopic dermatitis 196 2638 64806 3603 6364 6356 7908 6369 10344 2919 2920 3576 6352 6355 3553 PMC3970352__F2 Metabolic pathway of Inflammatory Response in humans 7054 324 920 PMC3974514__F1 Metabolic pathway of azathioprine/mercaptopurine metabolism 7172 8833 3704 PMC3975365__F1 Apoptosis induction and signaling 637 790 6418 PMC3976613__F2 Non-selective autophagy regulation during diabetic nephropathy (DN) 3479 253260 7249 7248 6009 7405 PMC3980740__F5 Signaling circuit driving transformation and tumorigenesis 6714 4854 3569 6935 6774 PMC3986510__F1 Ceramide de novo synthesis pathway 253782 91012 10715 79603 29956 204219 PMC3988467__F1 Amino acid signalling upstream of mTOR 6009 64798 64223 PMC3989546__F1 Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer 3716 3718 6774 3717 7297 6778 2885 9846 4609 3565 1789 PMC3995778__F5 Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies 9118 2744 7220 PMC3997674__F2 Signaling pathway of TRAIL/drug combinations 6774 6667 581 PMC3999173__F2 Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells 4055 4049 10563 6366 149233 196 4615 PMC4001725__F2 Estrogenic Steroid Hormones in Lung Cancer 1950 3273 3479 6714 2475 PMC400410__F5 Functional associations of genes identified by discriminant function analysis (DFA) in patients with juvenile rheumatoid arthritis (JRA) who were undergoing treatment 967 4783 3557 2512 3502 3630 6515 7040 1191 PMC4013419__F1 Major components of Sonic hedgehog (Shh) signaling pathway 6469 6608 51684 4613 2735 2737 2736 PMC4023255__F5 TGFB family signaling for Müllerian duct regression 268 269 4090 4086 657 90 4313 1499 PMC4031758__F2 Wnt signaling pathway 4040 4041 324 2932 1499 PMC4039115__F5 Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma with very poor outcome? 7157 2002 23411 4609 596 27086 595 1021 1019 PMC4043921__F4 Cytoskeletal proteins in cerebral cavernous malformation signaling pathways 2475 11235 5008 889 57154 4627 PMC4047366__F11 Metabolic feedback via HBP and N-glycan branching 2642 4245 4247 4249 PMC4051158__F1 Role of the CD40–CD40L pathway during the CD8 primary response 958 324 920 PMC4051995__F2 Mammary Development and Breast Cancer: The Role of Stem Cells 4851 4855 4853 4854 PMC4055924__F6 CD28 signaling in myeloma cells 942 941 940 PMC4058194__F6 In mTOR signaling pathway, there is the triplet of genes codes for proteins (orange nodes), and the pair (ATM and TP53) corresponds to interacting proteins in the cell cycle pathway (light blue nodes) 1956 7249 7248 4193 472 7157 6794 2475 PMC4059147__F5 Scheme for GAG biosynthesis (chondroitin/dermatan and heparan sulfate synthesis and keratan sulfate synthesis pathway) (A) and degradation (B) 64132 11285 126792 79586 6483 2135 2132 29940 55501 56548 113189 10090 8509 26035 9394 10855 60495 3423 2588 3425 411 2799 3373 23553 8692 8372 6448 3073 3074 138050 2990 4669 PMC4060523__F2 Signaling pathways that positively regulate ecdysteroidogenesis in the PG in Drosophila melanogaster 4087 7248 7249 PMC4062952__F1 Four androgen metabolism pathways to DHT synthesis 1646 1586 8644 PMC406534__F1 Proteolytic processing of APP is divided into an amyloidogenic and an antiamyloidogenic pathway 351 23621 102 PMC4066640__F5 MYC autorepression and general cellular gene repression by histone modification 5728 2146 4609 PMC4066980__F4 Model for Id1 regulation of melanocyte growth and melanoma development 3397 673 51491 PMC4067963__F10 Model of Sox9, Sox10 and FGF function during lacrimal gland branching morphogenesis 6662 6663 2255 2263 1280 1297 PMC4069269__F1 IL-18 signaling 10068 4615 114548 7189 3603 2626 3659 5728 59307 PMC4069315__F1 Mechanisms of action of lactic acid bacteria via extrinsic and intrinsic pathways of apoptosis 355 7124 578 PMC4073605__F7 Proposed model for the formation of reactive oxygen species at mitochondria, activation of Nrf2, and regulation of phase 2 gene expression in the nucleus 9817 5266 4094 PMC4075164__F2 Multiple intracellular signal transduction pathways are activated by GH 2690 3717 6714 PMC4079737__F1 Molecular Pathways: Niches in Metastatic Dormancy 596 659 10397 655 558 2621 PMC408106__F1 Partial synthesis pathway of GSLs 2813 4280 3074 PMC4081675__F1 Signaling pathways regulating hepatic stellate cell activation in alcoholic liver disease 7099 4087 4088 4089 596 PMC4083854__F2 Diagram showing the effects of knockout or blockade of specific elements of the alternative, classical and lectin pathways of complement activation on the pathogenesis of anti-MPO induced murine crescentic glomerulonephritis 718 5648 10747 720 727 729 PMC4086428__F3 Three commonly differentially expression MicroRNAs in pancreatic cancer tissue and patient blood: MicroRNAs 21, 155, and 200 5728 27250 8434 94241 4615 8651 673 6935 9839 PMC4088997__F5 Rapamycin and paclitaxel nanoparticles synergistically target the PI3K/Akt/mTOR pathway by suppressing feedback loop Akt phosphorylation 3667 5728 572 PMC4091181__F10 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells 23710 3916 10891 7416 PMC4091682__F1 EGFR/PI3K Pathway 1956 6774 5728 7249 2475 891 PMC4094296__F3 Pathogenetic Importance and Therapeutic Implications of NFKB in Lymphoid Malignancies 613 4615 6850 51135 3716 3654 695 6774 84433 10892 8915 2475 PMC4096794__F8 Sumoylation Pathway Is Required to Maintain the Basal Breast Cancer Subtype 7022 7020 3169 PMC4097927__F4 Polyamidoamine dendrimer-based gene delivery vectors 4810 1630 716 717 718 1431 PMC4098112__F1 Regulation of muscle mass 3479 3667 4087 4088 4089 PMC4100211__F1 Proposed frame work for mRNA nanoparticle mediated tumour vaccination 920 958 7098 51284 4615 3661 941 940 970 939 PMC4102744__F1 Cytoplasmic/traditional and nuclear modes of the epidermal growth factor receptor (EGFR) signalling pathway 1956 1950 1869 6774 595 PMC4103166__F3 Circadian Clock in Cancer Development and Therapy 472 1499 9575 PMC4105970__F5 Schematic model of specific KDAC targeting through pharmaco-logic modulation of its regulatory pathway 79004 3065 6667 3066 PMC4107458__F1 Neutrophil derived S100a8/S100a9 protein potentially contributing hypertensive cardiac fibrosis induced by Ang II 4353 6280 6279 7099 PMC4110479__F2 Proinflammatory properties of plasmacytoid dendritic cells (pDCs) 3553 7099 51311 51284 7098 54106 29110 10392 64127 6774 6714 3002 3661 3665 3716 7297 PMC4113246__F3 Gene Regulatory Networks in Cardiac Conduction System Development 6910 5308 6926 6474 10021 PMC4114922__F6 Function and regulation of the Rho guanine nucleotide exchange factor Trio 387 7204 5879 PMC4121837__F6 Proposed model for 18-5p–mediated inhibition of viral reactivation through the MAPK signal transduction pathway 613 5879 10746 PMC4125705__F4 Phenylpropanoid biosynthetic pathway in Ocimum sps 1431 100682260 1312 790 PMC4131779__F2 Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil 7048 7046 4088 4087 4092 6774 4089 6667 2313 PMC4135307__F1 Adaptive immune resistance of acute myeloid leukemia (AML) 940 29851 3458 PMC4137540__F2 Figures accompanying the sensitivity analysis 637 596 581 729 718 331 735 PMC4156078__F7 Schematic diagram depicting the proposed role of miR-130a in BMP-SMAD signaling and hepcidin regulation under iron-deficient conditions 654 148738 4089 4090 4086 PMC4158168__F6 Signaling pathway that metformin uses to regulate T cell and osteoclasts in autoimmune arthritis 7189 2475 6774 PMC4158832__F4 Planar cell polarity signaling in vertebrates 7474 57216 5754 1855 PMC4160369__F2 Molecular Approaches to Thyroid Cancer Diagnosis 7253 673 5728 2475 7157 PMC4171341__F3 Change or Die: Targeting Adaptive Signaling to Kinase Inhibition in Cancer Cells 3667 4763 5728 572 2475 8408 PMC4173667__F7 Schematic representation of a possible inflammatory pathway 3383 960 4615 PMC4174543__F3 Activated STING in a Vascular and Pulmonary Syndrome 3716 7297 6773 115004 3661 29110 PMC4174766__F2 Intracellular TLR signaling and trafficking in pDCs 51284 54106 4615 51135 81622 3654 7189 3665 7187 1794 PMC4175424__F2 Reactive Oxygen Species Adversely Impacts Bone Marrow Microenvironment in Diabetes 2937 5728 472 PMC4177547__F1 PI3K/Akt/mTOR pathway and relative inhibitors in NHL 5728 7249 7248 253260 6009 2475 PMC4178318__F10 Schematic of Rab23 functions in chondrogenic cells 51715 2735 6662 PMC4179679__F3 Metabostemness: a metabolo-epitranscriptional switcher 8473 23411 51548 PMC4179923__F6 Tazarotene Induces Apoptosis in Human Basal Cell Carcinoma via Activation of Caspase-8/t-Bid and the Reactive Oxygen Species-Dependent Mitochondrial Pathway 355 8772 637 331 PMC4182113__F1 Interferons: Success in anti-viral immunotherapy 7297 3716 3717 6772 3454 3455 PMC4196247__F6 Role of long-chain and very-long-chain polyunsaturated fatty acids in macular degenerations and dystrophies 60481 54898 64834 83401 6785 PMC4197719__F1 Mechanism of canonical HH signal transduction in vertebrates 2932 2736 2737 6608 6469 2735 PMC4199593__F7 De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana 3562 4803 596 5728 581 843 841 317 836 839 472 PMC4203741__F5 Long-HER Study: Clinical and Molecular Analysis of Patients with HER2+ Advanced Breast Cancer Who Become Long-Term Survivors with Trastuzumab-Based Therapy 5728 7249 7248 23770 6009 4018 5562 10554 PMC4211376__F7 DAPK2 is a novel modulator of TRAIL-induced apoptosis 8772 581 317 637 56616 331 23604 PMC4215179__F1 Protein trafficking of pericellular proteases 4313 4318 100187761 PMC4215754__F2 Visualization of KEGG B Cell Receptor Signaling Pathway after parsing and automatic correction 933 971 6850 4067 29760 10451 695 2885 3265 5894 2353 84433 161247 8915 930 4790 1147 3551 975 4792 10000 1380 2932 PMC4220655__F2 Selective autophagy in respiratory infection and sepsis 345611 80712 3553 7099 834 114548 PMC4222698__F2 Clinical utility of pharmacogenomics in the management of hepatitis C 57506 9021 6476 6772 6773 PMC4226441__F2 Targeting the estrogen pathway for the treatment and prevention of lung cancer 1839 7039 1956 6714 2885 PMC4235722__F2 Conservation between the Drosophila and the mammalian JAK/STAT pathway and their commonalities in inducing systemic and localized immune response and tissue growth 3570 3454 3455 9021 10401 PMC4236713__F8 TBB through the non-mevalonate pathway and gene annotation in T 3652 11113 4118 PMC4237867__F1 Signaling pathway of toll-like receptors (TLRs) 7096 10333 7097 7099 7100 4615 114609 51311 54106 51284 29110 7189 7098 3661 PMC4243360__F1 Pathways of apoptosis 596 581 637 9896 PMC4248697__F2 Synthesis of isoprenoid products in P 3652 4553 2821 PMC4252768__F2 Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders 7474 4920 6774 PMC4259419__F2 AXL kinase as a novel target for cancer therapy 1956 558 2885 2520 PMC4261235__F1 Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway 8544 3667 5728 5266 PMC4261510__F1 Wnt/Beta-catenin signaling pathway 4040 4041 324 2932 595 7008 PMC4264220__F1 Schematic representation of homocysteine metabolism and intersection with glutathione (GSH) production and folate cycle 875 4524 4397 PMC4266699__F1 HER family and EGFR signaling pathway 1839 7039 1950 1956 2475 PMC4268103__F1 Emerging roles of Notch signaling in liver disease 102 8650 1499 100188776 6662 4609 PMC4270129__F1 This figure shows the VEGF pathway for angiogenesis 2919 3576 3579 317 PMC4280579__F7 Integrated model of NDV-3–mediated protective efficacy versus MRSA in murine SSSI 324 3603 6774 920 PMC4280582__F4 Schematic representation of the HTRA2 protein and its activation against mitochondrial stress 1020 65018 27429 PMC4280670__F1 New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication 1956 7097 5156 2885 5728 7189 PMC4280670__F3 New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication 83939 468 1616 PMC4281710__F1 The domain architecture of NOD1, NOD2 and RIP2 10392 64127 84674 PMC4282344__F1 Pathways implicated in Alzheimer's disease (AD) 8301 6653 348 1191 10347 274 123041 3635 2041 10658 2185 57091 1378 10979 54209 79865 55063 5664 351 PMC4283800__F1 Hypoxia and the extracellular matrix: drivers of tumour metastasis 5351 5033 5352 8974 8985 283208 4015 4016 4017 84695 84171 PMC4288116__F4 Schematic illustrating the effect of p53 alteration on apoptotic pathway in basal-like breast cancer cells 4792 7124 8772 8717 3654 PMC4290619__F8 Signaling pathway of coagulation cascade for schizophrenia 1813 1814 2152 7018 7033 2161 2155 2160 2153 2158 2157 2159 PMC4290816__F1 Primary points at which PUFA-based supplements enter the PUFA biosynthetic pathway 9415 2717 54898 PMC4291618__F7 IAV facilitates bacterial adherence through the activation of the TGFB signaling pathway 4087 4088 4089 7018 PMC4298731__F6 Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma 7472 434 7481 4254 111 108 113 7976 11211 114 3815 4157 8323 1910 4893 2775 2771 2778 673 5566 1855 5330 5331 5604 2932 163688 1499 2048 815 6932 1638 2033 7306 64764 PMC4303261__F5 Computational Approach to Identifying Gene-microRNA Modules in Cancer 1291 50509 3678 7058 2335 3624 2191 1281 8038 4017 1462 4327 165 6999 4320 26585 1805 1513 4313 1893 4312 5328 PMC4303261__F6 Computational Approach to Identifying Gene-microRNA Modules in Cancer 3624 1311 633 7057 7058 1462 2335 358 3956 1307 3678 2191 1278 5329 3688 5054 4638 5328 8434 1833 1513 27295 794 59 4320 4327 7078 PMC4309023__F6 Core Hedgehog pathway and its cross talks 3549 50846 6469 6608 5741 2735 51684 PMC4309523__F5 An example from dGCspALL2 5790 695 729230 1236 3932 7305 3575 931 822 397 1520 3662 5450 PMC4316204__F2 Remodelling the extracellular matrix in development and disease 4318 4313 4323 4320 7054 1027 PMC4317626__F1 Complement activation pathways 717 4179 727 966 PMC4317864__F5 Schematic representation of the mechanism for UCA1-regulated metabolic switch 652995 2475 6774 406935 3099 PMC4331664__F5 The metabolic pathways of Mtb that interconnect glycogen, Tre and other carbohydrates 4118 4117 101448070 PMC4335796__F1 NLR-mediated suppression of canonical and non-canonical NFKB signaling 958 171389 4615 91662 147945 3654 64127 7189 197358 79671 5971 PMC4339430__F6 Proposed role of CCL21/CCR7 axis in lymphangiogenesis 6366 7424 729230 1236 PMC434255__F13 Current model for IL-7R regulation of survival and proliferation 3574 3718 3716 596 581 PMC4344846__F2a IQGAPs choreograph cellular signaling from the membrane to the nucleus 2932 324 8826 5901 84133 4040 4041 55366 PMC4345829__F5 MicroRNAs (miRNAs) and autophagy (adapted with permission from Ventham et al, Gastroenterology) 345611 406900 55054 64127 407050 407051 7099 PMC4346735__F1 Krüppel-like factor KLF10-mediated regulation of transforming growth factor (TGF)B signaling pathway in CD8+ and CD4+ T cells 920 4087 4088 7071 50943 PMC4347221__F1 Shifting ecologies of malignant and nonmalignant cells following BRAF inhibition 673 4893 613 6850 5894 PMC4350352__F6 TAp73 promotes anabolism 7161 6844 57030 PMC4357373__F11 Identification of microRNAs and their target genes in Alport syndrome using deep sequencing of iPSCs samples 7808 100 26136 4975 PMC4358823__F1 Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies 965 941 914 940 PMC4358823__F2 Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies 920 942 941 940 PMC4361250__F4 Hedgehog signaling in prostate epithelial-mesenchymal growth regulation 51684 2736 2737 6608 5727 PMC4366240__F7 Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 47 2194 6319 22937 6720 2475 PMC4367656__F1 Physiological changes with aging () 3479 5728 23411 2475 PMC4369380__F1 Distinct Integrin-Dependent Signals Define Requirements for Lytic Granule Convergence and Polarization in Natural Killer Cells 6714 3611 3383 PMC4373890__F2 Towards Anatomic Scale Agent-Based Modeling with a Massively Parallel Spatially Explicit General-Purpose Model of Enteric Tissue (SEGMEnT_HPC) 7099 4088 5728 6774 22943 1499 PMC4376865__F4 H-Ferritin-Regulated MicroRNAs Modulate Gene Expression in K562 Cells 55252 27297 9810 56254 7423 PMC4381776__F1 One-carbon metabolism in the cytoplasm and nucleus 4548 4524 1719 7083 PMC4394821__F1 Folate biosynthesis and utilization pathway (modified from reference ) 1725 1719 2356 PMC4396872__F1 Canonical and noncanonical NLR inflammasome activation 7124 6772 3553 PMC4397621__F1 Schematic model of novel inhibitors in Fas-associated death domain-Procaspase 8 interaction and Caspase 3 activation via Caspase 8 7124 8717 8772 PMC4397736__F2 Comparison between simulations and MFA experiments 1431 11113 7851 PMC4401766__F1 Simulation Predicts IGFBP2-HIF1A Interaction Drives Glioblastoma Growth 3485 7428 3091 PMC4404315__F2 Embryonic Stem Cell Self-Renewal 2260 2263 2261 2264 53834 6714 PMC4406394__F2 JAK2 Inhibitors: What’s the true therapeutic potential? 2056 3717 2475 PMC4407080__F1 Image of the MAPK signaling pathway painted by KPP according to the imported list of genes differentially expressed in the prostatic carcinoma as compared to normal prostate 2885 5891 8726 100187907 4149 929 23118 PMC4413232__F10 Sonic Hedgehog signaling maintains proliferation/self-renewal of cerebellar progenitor cells 6469 2736 2735 9055 PMC4422175__F7 Bile acid-activated S1P2 signaling 1956 6714 3667 1581 2932 PMC4423889__F3 Analysis of Glioblastoma Patients' Plasma Revealed the Presence of MicroRNAs with a Prognostic Impact on Survival and Those of Viral Origin 6015 4609 6689 7054 1053 978 4286 PMC4429670__F1 Vicious cycles in bone metastasis 2475 50964 22943 PMC4438385__F1 Brown adipose tissue uncoupling and thermogenesis 367 7038 7350 PMC4441763__F4 Quantifying Ubiquitin Signaling 27005 9099 90268 55611 65018 9927 PMC4444031__F4 Illustration of the Hedghog (Hh) signalling activation 22943 4040 4041 387 1499 324 51701 3725 PMC4445092__F2 Schematic presentation of testosterone-activated extra-nuclear signaling pathways 6462 367 6714 1956 PMC4446516__F1 Complement activation pathways and their regulators 718 5648 10747 717 720 1380 1378 727 729 730 735 966 PMC4449286__F5 Excess of rare, inherited truncating mutations in autism 2887 64599 26058 90850 10137 23112 PMC4450280__F4 Estrogen regulates TNFA NFKB signaling pathway of osteoclasts 5702 3784 5700 9861 5701 5709 5718 5713 5719 5707 5693 8792 PMC4450766__F5 EGFR pathway and the model of the effect of EGFR/MEK/EGFR + MEK inhibition on the pathway in RAS‐active NSCLC cell lines 1956 3845 5894 6194 PMC4453536__F8 Regulation pathway from HBV infection to complement activation 7189 1604 3553 3075 4179 3656 966 PMC4453937__F5 Summary of SIRT1 regulating the apoptotic upstream pathways within a cardiomyocyte in exercise-trained SD rats 355 3479 572 PMC4474305__F9 The differential subversion of type I IFN and mitochondrial apoptotic pathway by LCMV 57506 581 3661 7187 29110 PMC4479818__F1 Folate metabolic pathway 875 635 4548 4552 4524 4522 7298 1719 PMC4485494__F3 Glycogen Synthase Kinase-3 in Insulin and Wnt Signalling : a Double-edged Sword? 4040 4041 1499 324 PMC4486131__F5 OFE treatment counteracted TGFB1-activated SMAD pathways 4087 4088 1009 999 1000 PMC4489702__F1 miRNAs as biological and clinical determinants in colorectal cancer 27250 977 406968 574455 346389 6935 PMC4490046__F3 Cell Signaling and Transcription Factors Regulating Cell Fate During Formation of the Mouse Blastocyst 2625 1045 79923 2627 PMC4491684__F1 The Hedgehog signaling pathway mechanism 6608 5727 51684 57576 PMC4491880__F1 Deoxycytidine biosynthetic pathway 4975 117159 1854 PMC4493903__F1 LIF is a new p53 negative regulator 3976 3977 6774 3397 4193 PMC4494663__F14 New Biology of Estrogen-induced Apoptosis Applied to Treat and Prevent Breast Cancer 7124 596 8772 PMC4495933__F3 Secreted Frizzled-related proteins (sFrps) 89780 6423 649 PMC4499510__F1 WNT/Beta-catenin signaling pathway 324 2932 8658 1499 4040 4041 PMC4501067__F9 Biosynthesis pathway of neurotransmitters in insects 7054 7200 3067 1644 15 2744 1103 43 PMC4504424__F2 Cytokines determined to be up-regulated in plasma collected from pancreatic adenocarcinoma patients 6280 3565 6352 3569 2247 3605 7422 PMC4509978__F2 CMV-induced embryonic mouse organ of Corti dysplasia: network architecture of dysfunctional lateral inhibition 23493 474 2261 388585 2253 5629 3714 4851 5111 PMC4511812__F1 Hematologic malignancies: at the forefront of immunotherapeutic innovation 3575 3574 324 3146 920 PMC4516433__F5 Cerebral nitric oxide represses choroid plexus NFKB-dependent gateway activity for leukocyte trafficking 7186 3550 3383 6347 3627 3458 PMC4518644__F5 Example of using “Effect on Metabolism” tool to see the overall proteome result mapped on carbon fixation metabolism 4118 4958 3792 PMC4524427__F1 Insulin signaling network that links nutrition to growth and size 7249 7248 6009 1977 PMC4524510__F2 Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy 355 8717 8772 PMC4527365__F2 Activation and downstream signaling of class III RTKs 2322 1436 2885 PMC4538650__F2 Schematic of TRIM21 antiviral mechanism 55284 7334 7336 6737 23586 29110 3661 PMC4544004__F1 Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway 4118 4615 51135 7189 8772 3656 3654 7187 2002 3661 7098 7097 7099 51284 51311 54106 7096 PMC4544004__F8 The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway 7099 4118 7187 7189 51135 8772 PMC4553792__F3 Inactivation of DPH5 induces NFKB and death receptor pathways 7124 3551 3458 3553 4790 4792 6774 6772 3725 5970 3659 1950 1385 2033 1387 4088 6667 7157 PMC4559887__F1 Homocysteine metabolism and major factors associated with hyperhomocysteinemia in rheumatoid arthritis patients 5212 4524 875 4397 PMC4560835__F1 Recurrent 2,8-dihydroxyadenine nephropathy: a rare but preventable cause of renal allograft failure 100 4860 7498 PMC4569588__F4 Exploring the Altered Dynamics of Mammalian Central Carbon Metabolic Pathway in Cancer Cells: A Classical Control Theoretic Approach 545 5979 11040 2922 PMC4573392__F1 Emerging concepts in the regulation of hematopoiesis by inflammatory signaling 3458 6774 2056 9242 PMC4573710__F12 Proposed model of HDAC10 regulation in G2/M transition 83933 8091 890 PMC4576979__F4 Harnessing the apoptotic programs in cancer stem-like cells 2309 5315 3939 PMC4578651__F4 Chymomyza costata exposed to Long Day (LD), Short Day (SD) and Transfer (T) from LD to SD photoperiodic conditions 4661 1870 55055 79866 27161 84661 PMC4580089__F1 Intracellular trypanosomatid parasites evade the protective role of IFNG signaling by targeting essential components of the JAK-STAT pathway 3458 6772 3659 PMC4584337__F2 Comparison between the biosynthesis of isoprenoids in photosynthetic organisms (A) and the biosynthesis pathway proposed in haloarchaea (B) 717 1431 727 3652 PMC4586789__F3 Inhibitors of the Hh signaling pathway target different Hh signaling components 6608 6469 3549 50846 51684 PMC4590592__F8 Schematic view of the signaling pathways involved in healthy and CMML monocytes during CSF1-induced differentiation 1435 5031 5331 5336 10645 5562 8408 PMC4591933__F1 Non-invasive imaging and quantification of EGFR kinase activation in vivo 1956 1950 1178 23152 2885 PMC4593065__F1 The IGF-1R signaling network and nodes of therapeutic blockade 3480 3481 3479 3643 8660 3667 2885 2475 387 207 572 3482 PMC4599573__F1 Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells 387 2475 6010 2000 PMC4599573__F8 PLB regulates remodeling of epithelial adherens junctions pathway in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis 3082 324 5901 PMC4619386__F6 DDVP profoundly affects energy metabolism 2931 2998 808 5257 5226 7086 230 355 32 2806 3421 3945 8801 6389 6391 PMC4621978__F9 D receptor‐mediated ERK1/2 activation via the PKCD/EGFR/B‐arrestin2 signalling pathway in response to specific agonist stimulation 1956 1839 6714 PMC4625494__F1 Tubulin folding cofactor D (TBCD) cooperates with Dscam during neuronal morphogenesis.(A, B) Schemes of wild-type (A) and TBCD mutant (B) projection neurons 6904 1826 4151 7454 1155 PMC4626177__F6 Pathway network analyses of upregulated genes from early stage (stages II and IIIa) TNBC 4982 6772 1191 4036 5650 1000 3485 1501 25818 PMC4630008__F2 Different roles of Hh signaling in cancer 5727 6608 2475 2735 2736 PMC4633791__F1 Activation of effector and regulatory T cells by antigen presenting cells 50943 940 920 958 3383 324 PMC4633791__F3 Induction of cell lines of spy cells into functionally distinct Treg lines 920 50943 324 3568 3662 PMC4633791__F4 Newly recruited CD4+ T-cell soldiers induced to be spies 50943 920 324 PMC4633791__F5 Activated and aggressive CD4+T cell soldiers convert to spies 355 50943 920 PMC4633896__F6 Mechanistic model for irradiation-dependent and GSK3Beta-related signaling in HNSCC cells: Activated and inactivated molecules are displayed in green and in red, respectively 1499 2932 253260 2475 1977 PMC4641911__F3 Schematic representation of a hypothetical pathway in neurodegeneration involving stress signaling to and from the Golgi 1020 1027 22853 PMC4646278__F8 Overview of the role of pioglitazone activated PPARG and ROCK inhibition on survival of dissociated single hPSCs 1499 387 2932 999 PMC4647878__F4 Schematic mechanisms of action for drugs involved in the three arms of the TORAVA trial 3716 7084 7428 2475 8178 6772 6773 PMC4651701__F1 Targeting IL4/IL4R for the treatment of epithelial cancer metastasis 3565 3718 6778 3667 3597 2475 3716 3717 7297 8660 PMC4661823__F3 ER stress sensors and Programmed Cell Death in animals 22926 7186 83939 468 PMC4671322__F1 Molecular mechanisms underlying the oncogenic metabolic phenotype 1956 3480 5728 2475 4609 PMC4671741__F5 Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension 1506 5053 4548 875 2936 PMC4673348__F5 Proposed schematic showing targets of SA transcriptional regulation of insulin signaling pathway 3767 3643 8660 2475 5590 2645 PMC4675101__F8 Molecular pathway underlying interaction of Zn deficiency and miR-31 overexpression in promoting esophageal preneoplasia 6667 83931 6280 6279 PMC4676894__F2 Oncogenic (deregulated) intracellular signaling pathways in germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) 9294 914 286530 965 604 5728 6010 2146 596 PMC4682888__F2 Integration of Akt and mTORC1 signaling into the IL-4R and TLR4 pathways 7099 8660 3718 3716 6778 PMC4685486__F3 Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases 114548 9447 54106 3553 PMC4687794__F7 Signalling pathways downstream of CCK‐8s in pancreatic beta cells 886 572 8660 PMC4693592__F2 Monocytes from MS patients cluster independently from HV and display enhanced inflammatory pathways 4397 54210 3717 PMC4695904__F2 Oncogenic miRNAs involved in the apoptotic pathway 5728 90427 581 11113 PMC4703580__F5 Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases 54209 6850 7124 4615 PMC4704136__F2 Cellular and molecular interactions between CLL cells and the tissue microenvironment 613 6850 7412 958 952 3565 7852 3458 6351 6348 643 9242 6387 10563 PMC4707157__F1 Mechanisms by which mitochondrial DNA activates innate immunity 54106 3553 3661 PMC4714209__F1 Biosynthesis of Sec on its tRNA 118672 51091 4553 PMC4715089__F1 TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation 3553 4092 4087 4088 4089 PMC4716143__F3 Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection 718 727 721 1431 1401 PMC4720504__F1 Apoptosis pathway: (A) The different paths that a cell can take during the activation of cell death 7124 8772 317 84971 581 PMC4722981__F1 The mechanism of TRPC5 in mediating chemoresistance 7224 4775 1499 PMC4724610__F1 Systematic representation of microRNA biogenesis, deregulation and function 5901 54487 29102 27161 PMC4727530__F2 BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics 1956 673 2475 3845 572 PMC4729697__F7 Ingenuity Pathway Analysis (IPA) illustration showing upstream regulation of the pathway for NFKB 3606 7124 2908 8841 7157 PMC4730273__F3 The tryptophan (TRP) metabolic pathway 8564 8942 23498 23475 PMC4743801__F3 The globo-series pathway in human 10317 6483 2524 2523 PMC4748276__F5 ApoCanD: Database of human apoptotic proteins in the context of cancer 839 355 8772 331 8717 7124 596 637 2021 581 PMC4749929__F2 Pumping the breaks on B cell development 6850 29760 472 121599 3662 PMC4754913__F3 Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor metastasis 6370 10803 387 PMC4756853__F4 Pathways involved in thymidine synthesis in Escherichia coli, Drosophila melanogaster and humans 117159 1854 1635 4397 1719 PMC4756895__F1 Metabolic pathways – (a) Metabolic pathway of phenylalanine; (b) Pathway of urea cycle 162417 1373 5009 435 PMC4758349__F2 AIM2 inflammasome in infection, cancer and autoimmunity: role in DNA sensing, inflammation and innate immunity 3454 3455 6772 6773 10379 9447 2634 115362 115004 3553 3659 PMC4760780__F7 Proposed model for Usp12 function in the pathway of TCR signaling 50852 27040 219333 64854 PMC4765774__F4 N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli 8192 10845 1208 PMC4769158__F11 Proposed mechanisms by which loss of TRAF2 in keratinocytes causes a psoriasis-like skin inflammation 7124 7186 5966 4280 PMC4769825__F2 Schematic illustration of pathways associated with Nrf2 signal 9817 4094 5226 2539 PMC4782048__F7 Model depicting how AMPK regulates cell fate decisions through lysosome-dependent control of Wnt signaling 2932 1499 2475 7942 64321 PMC4799985__F1 Microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia 7099 929 23118 51135 7187 7189 3656 8195 3661 4615 114609 PMC4805512__F1 TNFR1-driven pathway 7124 331 197259 8737 11035 PMC4810382__F2 EGFR- and ALK-signaling pathways and their respective inhibitors 27436 238 2475 1956 PMC4810556__F1 Inhibition of innate immunity by arenavirus NP and Z 3458 7097 3454 3460 7096 10333 3455 7297 3716 3717 4118 4615 7189 10379 57506 7187 3665 3661 3654 6773 6772 PMC4811984__F6 Reduced dopaminergic transmission in the mesolimbic pathway may overrule orexigenic signals from the arcuate nucleus 4852 181 5443 23237 7054 PMC4824131__F1 NRAS mutant skin cell lines mutations in the TLR3 Cascade pathway 4893 3569 9252 4792 5609 1432 6196 7867 5608 3570 3656 6885 PMC4828451__F5 Complement activation pathways 5648 1378 2271 720 717 718 727 729 730 735 966 PMC4829114__F1 Metabolic pathway of P2Y12-receptor inhibitors 3552 3690 3674 PMC4839364__F1 (T)cell-inflamed and non-(T)cell-inflamed phenotypes 4283 3627 925 PMC4839493__F1 The metabolic pathway for vitamin D 120227 1591 5741 1594 8074 PMC4845654__F4 Beyond Beta-catenin: prospects for a larger catenin network in the nucleus 4041 4040 1499 324 2932 84662 5978 PMC4845657__F7 Nuclear factor KB1/RelA mediates inflammation in human lung epithelial cells at atmospheric oxygen levels 7124 4790 5970 PMC4856801__F1 Proposed model depicting the opposing roles of type I and type II NKT cells in inflammatory diseases in the liver 3458 1235 355 471 619501 PMC4862578__F1 Illustration of negative regulators of CaN-NFAT signaling pathway in cardiac hypertrophy 10231 11123 2274 11261 63928 1827 PMC4864964__F1 Processes involved in generation of the T cell-inflamed tumor microenvironment phenotype 941 4283 3627 PMC4865098__F7 Circadian rhythm pathway regulated by CTV-B2, CTV-B6 and CaLas-B232 1999 574414 80758 80742 PMC4867619__F3 IPA analysis: (Panel a) Top Network Cell Death and Survival, Inflammatory Response, Cancer 2247 4321 959 727897 7098 3316 6609 PMC4871335__F3 High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis 1581 3156 6713 2194 1384 79071 54677 1374 47 10965 122970 641371 1666 54898 9415 PMC4879129__F8 ASS234 targets involved in AD pathogenesis 351 847 581 572 PMC4884112__F8 Proposed crosstalk between EGFR signaling pathway and Hippo pathway in the diabetic kidney 374 1839 9113 4087 4088 1956 PMC4884928__F5 Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state 3569 6773 6772 1460 6774 598 10379 54205 3665 10410 9636 5610 842 3091 PMC4887998__F7 Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis 7098 6772 9242 PMC4898879__F7 Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light 1325 4280 94233 PMC4899619__F1 TGFB/Smad canonical signaling pathway 7939 4089 56 650 659 PMC4905210__F1 Targeting the mevalonate pathway using statins and its feedback loop using dipyridamole induces tumor cell apoptosis 3157 3156 3949 PMC4909198__F7 Transcriptome Sequencing and Analysis for Culm Elongation of the World’s Largest Bamboo (Dendrocalamus sinicus) 1312 718 790 PMC4915567__F1 Melatonin pathway and melatonin candidate genes 153 15 438 4544 4543 PMC4917523__F4 Schematic representation of the interplay between the IGF1 signaling axis and p53 genome protection pathway 3486 3479 3481 4193 3480 PMC4918704__F1 TLR4 (toll-like receptor 4) signaling: MyD88 (myeloid differentiation primary response 88)-dependent and MyD88-independent pathways mediate TLR4 signaling 7099 929 148022 114609 4615 353376 3661 3576 3569 6364 2920 7124 6347 6372 PMC4919052__F6 Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq 7018 3553 3659 3660 3172 4609 196 4780 6774 10891 3567 3586 3605 3596 3456 3458 183 3952 PMC4933442__F8 TNF-Alpha-induced expression of the inflammation-associated genes mediated by PLCE 4018 8682 2919 3576 6347 PMC4935144__F1 Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway 3667 8660 2887 7249 6009 2475 9675 64798 PMC4941807__F4 Ingenuity pathway analysis revealed hepatocyte growth factor (HGF) as an upstream regulator 3082 6774 3265 7157 7124 3091 7048 7056 7097 2 306 PMC4944541__F2 Crosstalk between leukemia cell and BM MSCs 7412 6347 5970 9242 PMC4951198__F10 Molecular and physiological defects in mice lacking BRAF and RAF1 in the epidermis 3558 3565 3567 85480 3569 673 5894 3606 3596 6354 PMC4954849__F1 Interplay between VEGF and Notch signaling is important for tip and stalk cell differentiation in physiological angiogenesis 1499 54567 5155 PMC4963809__F2 Schematic illustration of the canonical Wnt signal transduction cascade 2932 324 1499 4040 4041 PMC4973703__F2 Main lipid classes and biochemical pathways involved in the production of TAG in developing seeds 5662 4018 5091 PMC4977324__F2 Influence diagram of contains partial prior biological knowledge and epigenetic information in the form of methylation and histone modification 168002 147906 27123 51176 6925 6422 595 27121 22943 960 4609 PMC4987160__F4 Genomic Landscape of Male Breast Cancers 4595 2175 1636 26136 PMC4989114__F1 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate 127 8608 157506 64577 53630 PMC4990112__F2 BRCA1 promotes DNA end resection, but the BRCA1-A complex suppresses excessive DNA end resection 79728 675 672 PMC4997077__F1 Oxidative stress and mTORC1-mediated Treg cell differentiation 196 3569 50943 PMC5003773__F1 Empowering Regulatory T Cells in Autoimmunity 940 5728 2308 3516 50943 PMC5009710__F6 Simplified model for extracellular phytohormones that regulate enzyme-encoding genes or TFs in phytohormone biosynthesis by signal transduction pathways 2077 4609 4602 7018 PMC5036257__F7 A new SLIT/miR-218/(NFKB/POU2F2/ROBO1) signalling pathway promotes gastric cancer (GC) metastasis 6586 9353 5452 PMC5036929__F2 Drosophila JNK pathway 5817 474168 5879 4478 9618 7189 PMC5038604__F4 Protein-protein interaction network of the overlapped DEGs 56667 1465 2720 1080 87 4758 2059 7414 PMC5038883__F6 Proposed mechanism by which V8 induces apoptotic cell death in human multiple myeloma RPMI 8226 cells 83939 468 637 581 PMC5038987__F6 Proposed mechanism of the priming phase of complement-induced liver regeneration 3156 9023 9021 PMC5040721__F4 Possible antagonistic effects of obesity on myocyte signaling to accelerate muscle atrophy 2638 3569 3570 5728 440514 2475 28999 9021 664 PMC5045425__F4 Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma 9622 84680 3135 7037 3727 651 1839 5743 57018 7008 10103 405 2353 PMC5055500__F2 Diagrammatic illustrations of CCN1 signaling involved pancreatic cancer progression via CCN1-Notch1-SHh axes 3491 10983 6608 2735 6469 5727 PMC5061806__F2 Targeting mTOR for neurodegenerative disorders 7249 7248 2475 2056 1950 23411 627 PMC5065109__F2 Current hypotheses for IFNGamma-mediated effect on NSPC activity.Notes: IFNG binds to the IFNG receptor (IFNGR1 and 2) and activates Janus-activated kinases 1 and 2 and signal transducers and activators of transcription-1 (JAK-STAT1) pathway 3458 3459 3460 3717 3716 6774 6772 6469 PMC5079184__F3 IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction 3601 3718 6774 2885 PMC5083752__F1 Hedgehog signaling cascade 51684 6608 50846 3549 6469 64399 91653 2932 PMC5083752__F3 Hedgehog signaling activation in TNBC: interplay of ligand‐dependent and ligand‐independent mechanisms 3549 3091 6608 2296 4088 6469 8828 648 PMC5086085__F5 Ecdysone receptor B1 (EcR‐B1) signaling to trigger pruning in MB G and da neurons 4151 8403 3067 7415 PMC5090832__F1 JAK/STAT, Raf/MEK/ERK, and PI3K/PTEN/Akt/mTOR pathway cascades.In the JAK/STAT pathway, JAK2, which can be inhibited by AG490 and/or SOCS3, can phosphorylate STAT3 through downstream signalling 3717 9021 5728 2475 6774 PMC5090832__F2 Proposed signaling mechanism underlying the neuroprotective role of tPA.tPA enters the cell where it indirectly activates cellular signaling mechanisms, including Janus kinase 2 (JAK2) and/or mammalian target of rapamycin (mTOR) 3717 2475 6774 PMC5095680__F4 Impact of miR-140 overexpression on proteins involved in the NFKB signaling pathway 3553 80829 9507 3569 11096 PMC5105243__F2 Possible mechanisms for neuroprotective function of exercise and differences between sexes 3482 121512 10804 8564 54541 PMC5110879__F1 MicroRNAs biogenesis and function 29102 54487 27161 PMC5119517__F1 The PI3K/mTOR signaling pathway 5728 7249 7248 6009 PMC5120213__F1 Schematic model of the three apoptosis signaling pathways 9242 545 637 841 843 581 842 836 PMC5125043__F1 The inflammatory response to extracorporeal membrane oxygenation (ECMO) 718 730 729 735 3553 PMC5125867__F2 T cells in Systemic Lupus Erythematosus 29851 960 7097 6850 2475 1786 604 3662 6774 PMC5137585__F2 Diabetic cardiomyopathy: signaling defects and therapeutic approaches 5728 5163 3667 8660 2475 PMC5141645__F1 Schematic diagram of HGF/c-MET signal transduction pathway 3082 6774 2475 PMC5142116__F1 Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy 4860 55163 7008 9575 1628 3131 PMC5144577__F1 Canonical Notch signaling and Notch conservation between human and Monosiga brevicollis 1950 3714 182 8650 100188776 PMC514582__F10 Schematic of Nef signaling pathways and their relationship with Nef’s biologic effects in podocytes 6714 6774 5594 PMC5147738__F5 Portion of the miRNA-augmented Regulation of lipolysis in adipocytes pathway 10000 5140 23533 5290 11343 3643 57104 51099 3630 2167 5593 3991 PMC5174080__F1 Innate and adaptive immune responses induced by Avian leukosis virus (ALV) 51284 920 3661 PMC5182094__F2 Biosynthetic pathway connects cryptic ribosomally synthesized posttranslationally modified peptide genes with pyrroloquinoline alkaloids 581 3034 275 PMC5187837__F1 The integrin outside-in signaling 572 5879 2475 387 PMC5187938__F1 Proposed model of the role of KDM6A/B in definitive endoderm differentiation 7403 23135 22943 7473 1499 PMC5189614__F1 Cellular control of hyperglycemia 1950 3480 1956 2885 2475 PMC5190068__F3 KCNN4 and S100A14 act as predictors of recurrence in optimally debulked patients with serous ovarian cancer 3783 57402 7311 9314 PMC5209388__F1 Tetrahydrofolate (THF) synthesis, C1 metabolism, and triacylglycerol (TAG) biosynthesis in plant cells 907 5091 5053 1719 84890 PMC5209621__F7 Classic mechanism for E2 action is E2 diffusing into the nucleus, binding to the nucleus estrogen receptor (ER), combining with ERE on DNA, starting transcription translation and inducing the cycle of multiplication in cancer cells 2475 581 595 6667 PMC5214938__F1 Cross-regulation between interleukin-1 (IL-1) and type-1 interferon (IFN) inflammatory pathways as exemplified during Mtb infection 3603 3554 115004 3454 114548 9447 29110 3661 7850 5743 9023 PMC5217513__F1 AXL structure and effector pathways.Notes: Shown are the primary structural determinants impacting AXL activation and signaling 2621 558 6714 PMC5220330__F1 Interleukin-33 (IL-33)/ST2 signaling pathway 90865 6761 3556 4615 3654 51135 7189 PMC5222873__F4 Nuclear factor Y controls flowering time 175 1407 1408 735 718 PMC5235905__F9 LPS/TLR4 engagement promotes AMPK dephosphorylation and decreased kinase activity in peritoneal macrophages 7099 4615 3553 PMC524335__F7 Regulation of angiogenesis by the ancillary receptor endoglin 4087 4090 4086 4088 PMC5244336__F9 The mechanisms by which PRRSV infection upregulated miR-373 expression and miR-373 facilitated PRRSV replication 51135 3654 3656 6773 3659 10379 6667 51199 3454 PMC5247290__F2 Canonical Wnt/b-catenin signaling pathway 4040 4041 324 2932 1499 PMC5257007__F3 Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers 4118 5095 5096 2271 PMC5263152__F1 Canonical and non-canonical NLRP3 inflammasome activation 114548 7124 3455 7099 3661 3146 PMC5267446__F3 Acute myeloid leukemia and oncogenic Hedgehog/GLI signaling 6608 1859 9149 2322 2475 23476 PMC5285405__F5 Viral regulation of host proteins via post translational modifications 3661 5371 546 5970 8841 3475 1956 PMC5287922__F2 Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases 149233 3594 3595 PMC5292650__F1 Human myeloid cells identified in the bone marrow, blood, and tissue of cancer patients 929 9332 968 942 945 PMC529535__F1 Two models relating Akt and Tsc2 in cell growth control in Drosophila 7248 5728 6009 7249 PMC5300981__F3 TGFBeta-Smad signaling pathway in HSC 7046 4092 4087 4088 4089 PMC5302999__F2 Progress and perspective of TBX6 gene in congenital vertebral malformations 145873 9575 84667 6911 89780 PMC5303602__F6 Schematic describing the effects and proposed response on TLR4 signaling pathway and inflammatory cytokines resulting from resveratrol treatment and HFD 929 7099 7189 3553 PMC5318464__F1 Diagram of immune responses induced by Leptospira sp 7099 4615 7097 929 114548 3603 PMC5321852__F4 Hypothetical TRPC4- / TRPC6-mediated signaling pathway downstream of TGFB1 in InMyoFib cells 1000 1277 7225 7223 PMC5331196__F1 Sensing infection and tissue damage 6772 6773 10379 57506 3661 PMC5332937__F1 Canonical WNT signaling pathway 2931 595 100379198 1499 324 51176 4040 4041 PMC5335589__F5 The extrinsic pathway of the coagulation cascade was investigated in our study 7035 3552 7450 PMC5338429__F7 Model of Gata4 transcriptional regulation in atrial septation 2626 2735 1019 5728 PMC5341000__F10 Proposed scheme for the role of male sex on energy metabolism in the diabetic kidney 2821 3030 6418 PMC5345529__F1 Interaction of VHL protein with HIF and other proteins including elongin B, elongin C and CUL2 8453 7428 5155 7039 PMC5346332__F1 Constitutive low levels of IFNB that are produced by most cell types “prime” type I IFNs producing cells for a robust type I IFNs production upon sensing “danger” signals such as cytosolic DNA and TLR ligands 3455 3454 7297 115004 6772 6773 3661 29110 3665 PMC5346713__F8 Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women 5813 89780 87178 650 4087 4088 4609 29102 6935 7157 995 5268 27250 4085 PMC5352450__F2 Next generation sequencing and its applications in HPVassociated cancers 3105 3106 567 2261 1956 2064 2260 4055 9817 329 8772 4780 5728 841 7187 1029 1499 1021 8626 5925 1869 4609 7157 PMC5354739__F1 Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma 5243 9429 1244 4363 89845 8714 6573 2356 8836 2618 5471 471 1719 4524 7298 PMC5357236__F1 microRNAs in lipoprotein metabolism and cardiometabolic disorders 9619 8647 1581 768212 19 3931 PMC5357762__F2 Mutation rates of Wnt pathway components in selected cancer entities 4040 8549 54894 8312 324 2932 1499 55294 6934 PMC535924__F3 Molecular events shown by associated predicates 2885 3667 2002 6722 PMC5362499__F4 LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies 100187761 64065 847 PMC5368219__F1 Alterations in histone methylation in pediatric and adult high-grade glioma 4613 26097 673 1956 PMC5369246__F3 STAT-5-dependent activation of ATM and ATR pathways, required for HPV genome amplificationHigh-risk HPV activates STAT-5 to mediate TopBP1 transcriptionally to promote ATR pathway 6772 11073 472 545 PMC5372499__F3 USP15 acts as a “biological thermostat” in the TGFB signaling pathway 4092 9958 64750 PMC5379071__F4 Proteogenomic integration reveals therapeutic targets in breast cancer xenografts 8104 5053 6955 PMC5382021__F6 Group B Streptococcus degrades cyclic-di-AMP to modulate STING-dependent type I interferon production 115004 3661 84890 29110 PMC5386661__F10 Therapy-induced developmental reprogramming of prostate cancer cells and acquired therapy resistance 367 648 10215 4155 10381 2670 3381 PMC5387690__F7 A Caenorhabditis elegans Genome-Scale Metabolic Network Model 7851 2271 4149 PMC5388549__F9 Proposed mechanism for the effect of FPS-ZM1 in COPD 6277 3146 260431 PMC5397988__F2 Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy 637 581 355 PMC5400654__F4 Involvement of inflammation and its related microRNAs in hepatocellular carcinoma 4050 958 4055 4615 8717 7186 7187 7188 7189 5971 PMC5401756__F2 Leptin signal transduction 3717 6774 9021 PMC5401756__F5 Resistin signaling 7099 114609 4615 9021 PMC5401756__F6 Visfatin signaling 3603 6774 847 23411 51548 PMC5402045__F2 ST2/IL-33 signaling pathway 54106 90865 6761 4615 3654 7189 3659 2625 50943 PMC5402284__F6 Transcriptome profiling of sulfate deprivation responses in two agarophytes Gracilaria changii and Gracilaria salicornia (Rhodophyta) 2821 4351 2592 2973 412 5805 2638 PMC5405508__F7 Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in spleen 3958 6352 5698 5696 387 2358 5720 302 8651 3329 3105 PMC5405508__F8 Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in brain 6773 1969 4485 3476 1958 2353 6288 10125 7412 914 2064 25803 5008 9021 4792 57118 PMC5409837__F8 High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells 3479 3643 5156 PMC5415275__F9 The putative role of central insulin resistance in attenuating leptin modulation of rHypoE-19 hypothalamic neurons 6774 9021 2308 PMC5417715__F2 Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut 4201 5817 474168 1025 1956 6774 PMC5422340__F4 TGFB1-mediated regulatory network via Ingenuity pathway analysis 7157 5970 1053 4792 4790 6774 6667 5914 183 3630 PMC5423480__F3 Induction of an innate immune response to Ad-based vectors 7097 7096 10333 7099 4615 6773 6772 10379 54106 64127 PMC5429720__F6 DEGs related to fatty acid degradation and PPARA signaling pathway between APFL and AP 2098 7054 5468 PMC5429724__F3 Graphical summary of inter-variable connections for the entire BiliHealth study population 644 3263 1401 3258 3553 PMC5429724__F4 Intracellular levels of interleukins are related to circulating UCB and underlying molecular measures of heme catabolism 3258 644 1401 PMC5435082__F1 Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes 9415 2717 3992 PMC5449640__F4 Known KEGG pathway knowledge in cancer 2064 7157 3845 2263 5290 5295 7148 4018 207 4214 6416 PMC5455971__F2 Targeting iron metabolism in drug discovery and delivery 654 3569 151176 148738 3077 7036 6774 4090 4086 4089 57817 PMC5458753__F1 ZIKV genome structure and signaling transductions underlying ZIKV infection 558 7301 7098 2475 6773 PMC5462521__F1 YAP protein interaction, activation, and inactivation within the canonical Hippo Pathway 4771 4485 9113 PMC5468173__F4 An illustration of potential mechanisms in injury-induced vascular intimal hyperplasia is depicted 7099 4615 847 PMC5469033__F1 Adipose Tissue NAD+ Biology in Obesity and Insulin Resistance: From Mechanism to Therapy 203447 23410 23408 22933 23411 51548 23409 51547 10135 952 93100 PMC5479626__F7 Illustration of Hippo-p53 pathway in megakaryocytes (MKs) 387 26524 4193 PMC548008__F7 The molecular mechanisms involved in the TGF-Beta-Smad7 signaling pathway resulting in activation of Akt and p38, followed by phosphorylation and inactivation of GSK-3B 2932 1499 4092 PMC5481366__F1 Estrogen biosynthesis 8644 3294 7923 51171 1588 3292 51478 51144 412 6783 PMC5483433__F2 The potential roles of miR-M4-5p and miR-K12-11 in regulating the TGFB signaling pathway and promoting tumorigenesis 4052 7040 4087 4088 4090 PMC5485763__F2 Therapeutic Wound Healing Targets of miR-21Schematic diagram of miR-21 targets TIMP3 and PTEN 7078 3791 27250 1445 5728 5894 2475 572 PMC5487386__F2 Signaling pathways in innate recognition of fungal pathogens and differentiation of CD4+ T helper cells 7099 7097 4689 6850 51135 7189 5894 64170 114548 8915 3661 3665 3569 3459 958 3594 6775 920 PMC5495058__F2 Signaling pathway in sea urchin sperm 6395 2638 4827 PMC5502590__F1 Diagram of major TLR pathways 4615 3654 51135 114609 7189 10454 23118 PMC5507681__F8 Signaling pathways involved in keratinocyte growth and differentiation that are perturbed by SbIII and AsIII 1950 4851 1956 26018 8456 3848 PMC5512163__F3 Biologic and Clinical Perspectives on Thyroid Cancer 2475 1964 673 7015 7157 5979 PMC5513767__F1 Complementopathies 718 716 717 721 727 PMC5520878__F8 Schematic diagram illustrating signaling of EZH2 and its upstream activator and its downstream effectors in GC 652995 6667 2146 595 PMC5522055__F3 Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9 255738 3949 338 6927 2475 3643 6721 3172 3638 22937 3630 3156 267 PMC5522741__F1 Aging is a complicated process, often characterized by increased ROS and inflammation 2308 2309 23411 PMC5531462__F6 Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer 5567 2247 2122 2254 PMC5535862__F1 Schematic model proposing a differentiated cell as the cell of origin of skin squamous cell carcinoma (SCC) 57822 23152 5728 2475 PMC5539950__F1 Oxidative estrogen metabolism causes DNA adduct formation 1543 1545 1312 2950 PMC5553878__F6 Proposed model by which CCR7 regulated NFKB/VEGF pathway and induced angiogenesis in esophageal squamous carcinoma cells 1236 7422 7424 PMC5555522__F3 Molecular Pathway in Thyroid Cancer 7253 673 5728 2475 7157 PMC5564223__F1 The influence of Notch and Wnt pathways in the oncogenesis and stemness maintenance of breast cancer cells in the absence of estrogen 8650 3170 595 PMC5569090__F11 Schematic presentation of the mechanism for shell biomineralization mediated by the TGFB/BMP signaling pathway in molluscs 658 25805 659 4090 4086 4089 PMC5584301__F2 SETBP1 dysregulation in congenital disorders and myeloid neoplasms 26040 6418 4602 PMC5584596__F1 Duvelisib: A Phosphoinositide-3 Kinase D/G Inhibitor for Chronic Lymphocytic Leukemia 613 930 4067 PMC5585150__F1 Pro- and antitumoral effects of tumor-immune cell heterotypic GJICs 920 3439 7124 PMC5589138__F2 Normal and abnormal adrenal steroidogenesis in the zona fasciculata 1586 1589 1584 PMC5589692__F7 P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells 1003 1499 6714 PMC5590720__F1 Modes of action of Abatacept/Belatacept and anti-CD28 domain antibodies 652070 324 941 PMC5593157__F5 The signaling pathway 7249 7248 2475 PMC5605425__F1 Linking long non-coding RNA to control bile acid signaling and cholestatic liver fibrosis 1581 9294 283120 596 6935 4072 PMC5608833__F10 Rep-MYB-mediated repression of G2/M-specific genes under DNA stress conditions 472 545 4602 PMC5609576__F1 Cross-talk between adipocytes, macrophages, and cancer cells modulating the tumor microenvironment 7124 90865 6347 6351 6352 2919 2920 3553 PMC5609887__F5 Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer 10125 122786 11010 659 3720 85301 115908 6498 5329 4148 56675 11174 1839 7867 83729 1277 6591 PMC5613881__F1 A brief summary of the intracellular Hippo pathway in mammals 4485 9113 26524 PMC5617345__F2 IGF-1R/AKT pathway determines cell fate in response to p53 3486 3479 3480 5728 4193 PMC5617345__F3 IGF-1R/AKT pathway determines cell fate in response to p53 3479 3486 3480 4193 2932 PMC5618308__F1a Unlocking the NFKB Conundrum: Embracing Complexity to Achieve Specificity 8717 7186 7188 7189 4615 51135 10454 23118 257397 5970 PMC5618532__F1a Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 581 7249 596 2475 8408 PMC5618532__F2a Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 581 7249 596 2475 8408 PMC5628354__F5 Proposed deglycosylated metabolic pathway of Panax ginseng saponins by rat intestinal microflora 5925 2147 369 PMC5630446__F4 Bladder cancer stem cells: clonal origin and therapeutic perspectives 2932 324 1499 PMC5641214__F2 Leptomeningeal disease: current diagnostic and therapeutic strategies 4860 1719 2356 8836 PMC5646344__F1 Domain structure of Sina/Siah and its regulation in Drosophila and mammals 545 472 6667 28996 8445 6478 8975 2114 7291 PMC5649203__F2 Metabolic requirements of effector CD8+ T cells (Teff) 1374 948 2475 PMC5654406__F1 Sequence Evidence for the Presence of Two Tetrapyrrole Pathways in Euglena gracilis 210 7390 7389 1371 5498 2235 PMC5659363__F1 HCMV-encoded antagonists of the NFKB signalling pathway 3553 5970 5971 PMC5659363__F2 HCMV-encoded agonists of the NFKB signaling pathway 3603 472 5970 PMC5661282__F9 Role of glycolysis in NPC self-renewal 2254 655 3479 3481 10736 4435 PMC5662125__F1 Bile acid receptors link nutrient sensing to metabolic regulation 1593 1581 9420 1582 PMC5664647__F1 Working Figure of the Angiogenesis Pathway Genes 2321 3791 7010 7040 3576 3577 3579 3553 7124 1959 1956 3667 7421 PMC5668920__F1 Fas apoptotic pathway 940 355 4893 987 PMC5675701__F8 Long non-coding RNA CRNDE acts as a ceRNA and promotes glioma malignancy by preventing miR-136-5p-mediated downregulation of Bcl-2 and Wnt2 643911 7472 2475 PMC5684300__F2 Simplified diagram depicting canonical and non canonical Beta-catenin signalling pathways in bone 4920 5741 324 1499 860 PMC5685683__F6 BMAL1 facilitates trophoblast migration and invasion via SP1-DNMT1/DAB2IP pathway in recurrent spontaneous abortion 4313 4318 153090 PMC5691642__F2 Suppression of type I IFN production by Flaviviridae viruses 10379 6773 57506 6772 7297 57762 3455 29110 3661 3665 PMC5694536__F7 Schematic diagram depicting the role of Hoxa2 in proliferation and osteogenic differentiation of the palatal mesenchyme 3199 121340 9049 860 PMC5697091__F7 List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S 7097 5879 3603 10333 114609 8772 3929 929 23118 51135 7099 4615 7189 958 941 942 5132 1513 130749 54106 3661 7098 7187 3665 PMC5706935__F1 PARK2 loss connects AMPK-mediated nitrosative stress to PI3K/AKT activation 10645 1956 6714 5728 PMC5708160__F1 Strategies for Comparing Metabolic Profiles: Implications for the Inference of Biochemical Mechanisms from Metabolomics Data 353 8833 2766 84890 100 PMC5709727__F7 TNF‐p100 pathway subverts noncanonical NF‐KB signaling in inflamed secondary lymphoid organs 4055 7186 7187 5971 PMC5710859__F1 Molecular insights into desmoid tumors 182 2191 324 2932 1499 3280 6925 PMC5711827__F1 Innate immune signaling pathways that drive type I IFN responses in mycobacteria-infected host cells 80712 7099 115004 29110 64127 3661 PMC5712330__F5 Targeted therapy in extranodal marginal zone lymphoma 613 330 10892 4615 51135 84433 7189 8915 2475 7128 4609 10320 22806 27086 604 3662 PMC5713646__F1 Chemical synthesis of n-butyraldehyde from petrochemical feedstock 847 3045 100187828 PMC5715847__F2 Wnt/PCP pathway 387 5879 23002 6093 3725 PMC5716829__F1 Different PPGL molecular subgroups with corresponding driver mutations and a proportion of hereditary disease in the respective cluster 7428 7812 5979 4763 6389 6391 2271 6392 6390 2034 55534 4149 3265 55654 54949 4609 2475 PMC5717006__F2 Mevalonate metabolism in immune and cancer cells 4609 355 920 948 3652 2475 11119 19 PMC5718065__F8 Schematic diagram illustrating potential interactions and changes in Ten-m3 KOs 7546 2047 2045 PMC5725018__F6 Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway 7474 1499 51176 PMC5726598__F8 PIK3CA cellular signaling pathway 1956 5728 7249 7248 2475 PMC5727541__F4 2-hydroxyisobutyrylated enzymes involved in TCA cycle, pentose phosphate pathway, pyruvate metabolism, glycolysis/gluconeogenesis and starch biosynthesis pathways 2539 25796 5226 7086 6120 22934 2597 1737 1738 2271 6389 1743 4967 PMC5731741__F3 FGMD: A novel approach for functional gene module detection in cancer 84541 864 64005 11262 914 55281 952 221472 4063 51411 94240 165631 25939 940 286336 8514 257106 10346 7412 921 149628 916 3932 3738 3003 57823 53347 6693 27350 752 64098 4067 117289 915 55423 5452 118788 8320 834 11184 1520 4064 729230 3702 89857 151888 27240 3594 1230 80342 92241 923 5330 8875 10673 80709 10663 PMC5739070__F3 Optic Pathway Gliomas in Neurofibromatosis Type 1 2475 5879 6714 PMC5745765__F10 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F11 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F12 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F4 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F5 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F6 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F7 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F8 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5745765__F9 Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature 3458 90865 85480 909 7040 3082 PMC5749594__F3a Association of the activity of metagene 19 with two distinct image phenotypes 26018 1950 1956 5266 3845 PMC5749594__F3b Association of the activity of metagene 19 with two distinct image phenotypes 26018 1950 1956 5266 3845 PMC5750051__F3 Proposed pathway for B12 targeting to methionine synthase for MeCbl synthesis 27249 4397 25974 PMC5751130__F1 Regulation of the TGFB signaling pathway by miRNAs 4092 64750 4087 4088 4089 PMC5751326__F2 Role of IFNB in host–pathogen interaction in Mtb infection 3553 115004 114548 29110 9447 3661 PMC5753157__F1 T-helper responses to A 7054 3458 1493 90865 6774 196 2625 6778 PMC5753398__F1 Hedgehog signaling pathway 50846 3549 6608 2737 2736 6469 64399 2735 PMC5763539__F3 Pathway map for “LRRK2 and immune function in Parkinson’s disease” 2214 5717 641373 6770 8826 PMC5764090__F1 HiJAKing the Epigenome in Leukemia and Lymphoma 3976 7173 2056 3562 3717 6774 PMC5766647__F3 Regulatory T cells are controlled by epigenetic mechanisms and T cell receptor (TCR) and interleukin-2 (IL-2) pathway 50943 2475 29851 PMC5770391__F4 Changes in brain energy metabolism during worker maturation elucidated by pathway analysis of data from brain RNA-seq experiments 5091 1737 1431 2271 47 1743 4967 PMC5777140__F5 Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer’s disease 7450 960 255743 1101 948 6420 961 PMC5778124__F6 Inhibitory nucleotide-binding oligomerization domain (NOD)-like receptors put the brake on NFKB activation via canonical and non-canonical pathways 958 7124 4615 3654 7187 7189 5971 PMC5778870__F1 Interaction of miRNAs as oncogenic and tumor suppressor 3265 5728 1869 PMC5779720__F2 Distribution of fluxes in the central metabolism predicted by pFBA for the models: iFF708 (green), iMM904 (blue), iTO977 (orange) and Yeast 6 (black) 5132 4118 11113 PMC5791855__F1 Tuning the depth of quiescence for cancer therapy 595 4609 1021 1019 898 1017 5925 PMC5794005__F1 Denosumab: Targeting the RANKL pathway to treat Rheumatoid Arthritis 3458 126014 7187 7189 4772 PMC5798243__F1 Physiological events post-BCG exposure: UC cell exposure to BCG results in A5B1 receptor mediated BCG internalization involving A5B1cross linking 2919 2921 6374 PMC5800892__F7 TRAF-STOP Treatment Reduces Atherosclerosis and Preserves ImmunityBinding of CD40L to CD40 results in the recruitment of tumor necrosis factor receptor-associated factors (TRAFs), and propagation of signaling 958 940 941 942 7189 100188864 8178 PMC5803919__F1 Systemic iron homeostasis 7036 3077 654 151176 57817 9843 PMC5809440__F2 Assessment of liver microenvironment through whole-genome RNA Seq 941 942 5610 10561 64135 3434 3433 3437 10410 3665 3661 9636 4615 6775 7187 4939 4940 29110 10454 100187907 6955 PMC5810418__F10 Two B-hyperpaths computed in the full NCI-PID signaling pathway 367 7088 3065 2932 324 1499 8312 PMC5810846__F1 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics 4040 1499 324 51176 PMC5810846__F4 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics 10188 29 4827 PMC5811610__F6 Sialylation pathway in eukaryotes 10559 55032 113829 55907 54187 140838 6568 63910 PMC5811630__F7 Iron starvation responses 4860 117159 1854 5162 4018 4553 PMC5814934__F6 Working model 920 23476 3516 4851 PMC5817364__F2 Polyphenols for the treatment of NAFLD 948 5465 3667 9817 PMC5819894__F11 Metabolic enzymes targeted by p53 9997 3099 2539 PMC5823541__F1 MTOR signaling pathway and the cell cycle pathway associated with lung adenocarcinoma as reported in 4763 472 4193 6794 7249 7248 7157 2475 PMC5828949__F2 The role of renal dipeptidyl peptidase-4 in kidney disease: renal effects of dipeptidyl peptidase-4 inhibitors with a focus on linagliptin 2260 1803 4088 7046 PMC5831574__F8 Analyses of the potential molecular mechanisms of EPB41L4A-AS2 by a bioinformatics-based method 5594 4773 9844 64097 254896 7058 6093 659 9530 143686 64101 4915 5028 57502 7046 3479 2829 7124 103724388 57551 51735 2475 PMC5834792__F3 Drug resistance in anaplastic lymphoma kinase‐rearranged lung cancer 7039 3082 1956 2065 27436 238 PMC5843355__F1 Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery 353 9615 8833 158 2766 PMC5844827__F1 Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment 10800 2205 56477 920 2625 PMC5857537__F7 Molecular alterations in cortisol-producing benign adrenal cortical neoplasms 5566 5573 4158 PMC5861627__F1 Canonical activation of Shh pathway in vertebrates 6608 2736 3815 PMC5862799__F3 The metabolic pathways utilized by T cells in nutrient replete versus metabolically challenging environments 3091 2475 50943 PMC5867104__F2 Wnt/beta‐catenin pathway‐related lncRNAs and their interactions in cancers 643911 100124700 3190 100270680 1499 7475 652995 100316868 6932 8325 55384 PMC5869528__F11 Jak-STAT signaling pathway 2056 8027 5292 PMC5873314__F1 Theoretical model of how genetic polymorphisms influence symptom burden during breast cancer treatment 4803 1312 627 PMC5874734__F1 Induction of necrosis by L 3661 11035 197259 55364 942 940 PMC5883378__F2 Two signaling pathways 7097 7099 7100 10333 7098 51284 4118 4615 7187 7189 3661 3665 51311 PMC5884799__F7 MS TLR signalling pathway 5970 3553 6774 3569 710 3448 7124 958 5447 6347 1431 8178 PMC5884799__F8 Multiple sclerosis pathway 3458 2099 135112 1958 3949 5800 1514 PMC5889282__F7 BGN- and DCN-mediated inhibition of the TGFB pathway and restriction of HER-2/neu signaling 1634 7048 633 1956 7046 PMC5889571__F2 CD109 and TGFB signaling 7048 135228 4087 4089 7018 PMC5891012__F1 Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations 1956 2885 2922 PMC5891907__F1 Scheme of the innate immune response to injury 7099 4615 6347 3661 PMC5893867__F1 Fasciola hepatica modulates macrophage activation 57716 7099 929 7098 114548 PMC5903427__F1 Purine salvage pathway and HGprt function () 435 4860 100 PMC5904231__F2 Process diagram indicating the p16INK4a/p14ARF–RB–p53 pathway in normal conditions 545 472 26038 PMC5912962__F1 Comprehensive Review of Genetic Factors Contributing to Head and Neck Squamous Cell Carcinoma (HNSCC) Development in Low-Risk, Non-Traditional Patients 545 2175 2189 PMC5937133__F1 Type 1 diabetes pathogenesis and B cell protective factors 324 920 3458 7124 PMC5943571__F1 Pathway for glycosphingolipids (GSLs) biosynthesis 8705 7971 6483 PMC5949009__F6 Schematic of accelerated tissue regeneration pathway via the dynamic and adaptive HMGB1–CXCL12–CXCR4–GAlert axis 3146 6387 7852 PMC59539__F2 Schematic model of Shh/Fgf10/Bmp4 signalling during lung branching morphogenesis 6469 2263 652 2255 6608 PMC5954269__F1 Vitamin D Pathways: An Overview (source: Nutrients 2016, 8, 319) 1628 1593 120227 1591 5741 1594 PMC5955138__F1 Natural product based sensitization of GBM 5728 4255 572 2308 4193 PMC5959746__F3 The biology and therapeutic management of melanoma brain metastases 6347 5728 7124 PMC5961736__F1 Illustration of cross-communication network of BCR, PI3K, and NFKB signaling pathways that harbor effective therapeutic targets in lymphoma 958 613 695 4615 6850 84433 8915 5728 5970 2475 5971 PMC5961736__F2 Illustration of JAK/STAT signaling pathway that inspires effective therapeutic targets in lymphoma 6714 2475 595 596 4609 PMC5966448__F6 Modeling the potential cellular roles of three genes upregulated by AnAc in MCF-7 and MDA-MB-231 cells 11245 5166 47 51548 26137 2308 PMC5966782__F1 Glucose catabolism 2539 5723 26227 PMC5969225__F3 Hh–Gli signalling in myofibroblasts 50846 6469 3549 6608 5727 PMC5969374__F4 Disrupted signaling pathways in GCB-DLBCL 9294 151888 2146 8764 604 387 596 4609 2475 2638 PMC5980236__F1 Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells 4598 9961 3652 PMC5983921__F3 Wnt/Beta-catenin signaling pathway 84133 1499 324 2033 7008 4041 PMC5985737__F3 Relation of the studied NAFLD risk alleles to the main pathways in hepatic triglyceride partitioning 7038 2646 127018 471 80339 53345 PMC5991421__F1 Computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention 2271 1378 718 727 729 730 966 PMC5993148__F3 SLC7A11 regulates nutrient dependency of cancer cells 23657 6520 2744 PMC5996766__F1 Of Pleiotropy and Trajectories: Does the TGFB Pathway Link Childhood Asthma and COPD? 7040 7042 7049 57154 4091 7189 4087 4088 4092 6497 64750 5914 196 7421 169792 5915 6660 864 3665 8928 PMC6008965__F2 5-Fluorouracil drug pathway demonstrating the interaction of multiple gene products 1807 1854 6241 5972 2356 8836 2271 7054 759 1841 PMC6010520__F9 Proposed model for illustrating the essential roles of DNA sensors in recognition and innate interferons (IFNs) production during ectromelia virus (ECTV) infection 115004 3665 51428 29110 3661 54106 PMC6015663__F4 SHP2 plays a key role in NSC proliferation, differentiation, and migration 2885 6774 1950 7852 PMC6016729__F6 Where Hematopoietic Stem Cells Live: The Bone Marrow Niche 1499 23405 51119 PMC6016890__F3 Mechanisms behind low levels of hepcidin in liver disease 57817 3077 7036 PMC6017063__F1 Therapeutic targets in the Notch signaling pathway 182 3714 28514 10683 54567 PMC6021501__F2 Role of apolipoproteins during early steps of hepatitis C virus (HCV) entry 975 338 348 3265 3949 1956 9076 PMC6023766__F4 Apoptosis signaling pathway and its control by phosphorylation 572 90427 638 8739 637 581 PMC6024232__F2 The pathway of acylceramide synthesis in keratinocytes 6785 64834 126410 204219 2531 285848 PMC6027519__F2 Regulation of innate and adaptive immunity by hypoxia and HIF signaling pathway 3569 3576 100187907 55364 PMC6027703__F5 Relationship between Beta-catenin, MEN1, and NCOR1 mutations and the Wnt signaling pathway summarized 1499 9611 4221 PMC6030495__F6 EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival 1950 1956 6714 6774 PMC6031328__F2 Regulatory mechanisms for alternative splicing impact numerous components of the CME 1213 1211 1212 51429 22905 29924 8650 2060 9026 6453 50618 9892 23149 115548 1601 9829 2580 PMC6040266__F7 Mitochondrial sulfide-oxidizing pathway 23474 29984 718 PMC6049507__F6 MiRNA targets in cancer pathways 1788 1387 4193 PMC6049507__F7 MiRNA and host targets are involved in common pathways 4802 3320 5879 5604 1027 894 PMC6052044__F1 Metabolic pathway reconstruction for Spirochaetes in hydrocarbon- and organohalide-contaminated environments 2147 2153 2152 PMC6057142__F1 Wnt/Beta-catenin signing pathway 4040 2932 324 1499 PMC6060268__F4 Overlapping actions of metformin and rapamycin 2475 1977 1975 6194 PMC6066316__F8 Differentiation of monocytes promotes resistance to ripoptosome signaling 8737 331 7099 3454 11035 197259 PMC6066558__F4 Soluble klotho pleiotropic functions and FGF23 – sKlotho interactions 8074 7225 3480 2264 PMC6070911__F1 Biosynthetic pathway of ansamitocin P-3 2592 51083 1636 65057 PMC6072829__F7 Zyflamend and NFKB pathway 7316 595 4318 4313 PMC6073315__F1 Schematic illustration of hypothalamic regulation of energy homeostasis 1392 7200 4160 4852 181 5443 2475 23237 5091 PMC6077295__F2 Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis 673 3845 3490 4255 PMC6080611__F2 Molecular regulation in autophagy 2475 55054 23192 PMC6087715__F1 JAK–STAT signaling and core cancer pathways 1499 6774 5728 PMC6089072__F3 Methods for observation and quantification of apoptosis 7124 355 4975 PMC6096230__F2 Notch signaling in mesenchymal stem cells 3280 4851 50943 3714 182 920 PMC6116003__F2 Pathway for Type I tumor formation 3845 673 2064 5728 8289 PMC6120701__F3 Interleukin (IL)-2 signaling pathway 3559 3560 3716 3718 2885 5894 7018 PMC6123661__F8 Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models 80199 5879 7074 PMC6125368__F2 Scheme of possible mechanisms by which autoimmune diseases are mediated by IGF-IGFBP signaling pathways 5728 3667 2475 PMC6128059__F1 Representation displaying the two different signaling pathways, RET-dependent (A) and RET-independent (B).In RET-dependent, glial cell line-derived neurotrophic factor (GDNF) binds directly to GDNF family receptor alpha (GFRA)1 2668 5979 2674 2534 2353 PMC6129988__F1 Current pathogenic model of psoriasis 2919 6772 4283 3627 6373 3934 5132 29949 6774 6364 1235 9308 PMC6130939__F11 GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation required for PI3KG/PREX1 signaling and robust T cell cytokine secretion 7852 6714 57580 156 PMC6136541__F4 E2 on bovine mammary epithelial cells during Staphylococcus aureus infection 7097 3553 6278 3603 PMC6142519__F3 Aberrations in the Ras signaling pathway that lead to excessive proliferation 2885 9846 867 4763 PMC6146372__F3 Autophagic control of Toxoplasma gondii 958 1956 7189 8408 3458 3916 PMC6147049__F5 Canonical Wnt/Beta-catenin signaling pathway 100187761 2932 324 595 4316 960 847 PMC6149803__F1 Mediating the death of dormant tumor cells 7297 6714 196 6774 PMC6149873__F1 Inverse relationship between canonical and non-canonical Hedgehog signaling in colon cancer stem cell (CSC) differentiation 6608 5727 2735 PMC6152404__F6 Proposed mechanism for the proliferation inhibitory effects of ART in HCT116 cells 51703 3033 2194 8178 PMC6156325__F4 BH4 modulates the nitrosation of key proteins in the Ubiquitin-Proteasome system 5717 9861 5708 PMC6157734__F2 Human CARD9 signaling pathway 6850 64170 3265 8915 10892 1437 3553 3569 2919 2920 PMC6160542__F1 Fibrogenic secretome pathways in the development of fibrosis 27122 22943 4040 4041 2932 23411 1499 100188776 PMC6161739__F2 NLRP3 inflammasome assembly 114548 7124 79792 PMC6162467__F4 CCN2 in regulation of LRP5/6 dependent Wnt signaling 7474 1490 1499 PMC6165231__F1 Hedgehog (Hh) pathway activation 6469 6608 1956 51684 PMC6167501__F4 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy 2932 1499 847 51199 607 324 1356 PMC6170637__F3 Animal and plant cells 7099 4118 5640 5901 7054 PMC6172046__F7 Taurine Upregulated Gene 1 signaling circuit in osteosarcoma 5290 2305 55000 5266 PMC6177401__F3 Dengue virus and the host innate immune response 7099 7297 3716 735 721 10379 729 727 6773 6772 PMC6177564__F2 Schematic illustrations of identified pathways in hepatitis C virus-induced liver carcinogenesis 1499 619501 57762 PMC6177712__F2 Schematic depiction of cannabinoid and exemplar mono‐, sesqui‐, and diterpenoid biosynthesis 3652 412 717 727 PMC6178832__F2 Molecular features of the JAK-STAT signaling pathway 3601 3560 3594 3595 149233 3454 3455 3716 7297 6774 6778 6775 6772 6773 10379 7084 PMC6189490__F1 Salvage and de novo synthesis pathways for UTP synthesis 4975 139596 7372 PMC6190278__F1 Heterologous effects of infant BCG vaccination: potential mechanisms of immunity 7099 929 1950 969 2475 PMC6197541__F1 Associated cell signaling pathway and related potential therapeutic areas 7939 4089 4088 3091 PMC6202106__F7 The TGFB/BAMBI pathway 4087 4088 50943 6097 25805 PMC6203874__F1 Cholesterol-dependent cytolysin 2222 9453 2224 3156 PMC6207163__F2 Modulators of Redox Metabolism in Head and Neck Cancer 1956 1950 6714 2885 6774 5728 2475 PMC6207918__F10 TGFB/ALK1 signaling at the BBB and regulation of the Slco1a4 gene 4090 4086 4089 PMC6212884__F1 Canonical TGFB/SMAD signaling pathway 4087 4088 4092 4089 7046 PMC6220476__F1 Circular RNA ITCH and 0043256 act as miRNA sponges to regulate the expression of ITCH 100302136 83737 1499 PMC6224214__F8 Liver X Receptor (LXR) pathway as the result of the integration between transcriptomic and metabolomic data 1071 3033 3156 337 PMC6232290__F2 IL-13 signaling mechanisms in the treatment of ulcerative colitis 3596 3565 3716 6778 3598 3597 PMC6240570__F1 Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches 6608 1499 324 51199 51684 27148 PMC6245977__F1 RAS signaling pathway with proteins mutated in JMML in red 2885 3717 9846 867 2475 PMC6248540__F2 Pathway analysis infers molecular pathway of relapse 960 8727 50807 6010 7038 PMC6262325__F1 Canonical hedgehog signaling pathway 374654 51684 6608 PMC6263010__F1 Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus 4280 2670 6657 1641 5727 PMC6270990__F2 PD-1 action on T-cells 940 941 942 920 324 PMC6273696__F33 Tight junction signaling pathway was regulated by vancomycin in HK-2 cells 6810 100170220 2011 57530 8573 6294 100506658 5728 5872 7414 9863 9118 7124 PMC6277637__F11 Inflammatory pathways in osteoarthritis 3553 7054 5741 PMC6280705__F1 General eukaryotic translation initiation pathway 1977 1998 1999 2001 1983 83939 9669 PMC6281419__F1 PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy 3479 3481 3480 7094 3667 8660 55023 595 PMC6287621__F1 Specific targets and potential therapeutic strategies to inhibit or slow the progression of CKD 27035 50507 7049 3082 655 PMC6287681__F2 Signaling pathways that induce necroptosis 8737 11035 841 8772 PMC6287681__F3 Signaling pathways by which NPs induce apoptosis 578 581 8772 637 841 100506742 54205 317 842 839 840 836 PMC6290495__F4 Regulatory model for the flow pathway of central carbon metabolism and a proposed scheme for lipid biosynthesis in T 27349 1431 4967 4018 5183 2597 PMC6299256__F3 IL-27 induction by C 3454 3455 6773 6772 51284 64127 4615 PMC6302218__F2 Autophagy and the inflammasome 3603 114548 3553 PMC6304530__F1 The reprogramming of metabolism in cancer 3603 5728 2475 4609 2744 PMC6305104__F3 MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer 7066 3717 5447 PMC6306333__F5 Proposed working model 3553 3576 3603 PMC6326574__F1 Immunological mechanisms responsible for radiation-induced abscopal effect 115004 324 4599 3661 PMC6328495__F1 The regulation of the mevalonate pathway and the role of mevalonate-derived metabolites in cell proliferation 29914 3156 22937 PMC6329466__F1 Neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) receptor signaling pathway and inhibitors 627 4803 4915 4916 PMC6330352__F2 Cardiac and macrophage inflammatory pathways 7097 7099 4615 3654 7189 3553 PMC6331247__F2 Pathway for the relationship between MS4A6A SNPs, blood gene expression and Alzheimer’s disease phenotype 183 175 64231 51338 PMC6333462__F1 Methyltransferases linked to regulation of autophagy 6502 10498 4200 10919 2475 23476 84148 23411 PMC6336165__F2 Theory for polymicrogyria and brain arteriovenous malformations in HHT 54567 27302 7422 5728 PMC6338642__F7 BMP4-mediated anti-cancer effects in ER+ breast cancer 652 4090 4086 1019 4089 1021 595 PMC6341984__F1 Tuberculosis and impaired IL-23-dependent IFNG immunity in humans homozygous for a common TYK2 missense variant 3454 3594 149233 3717 7297 3716 6773 6772 6774 6775 7084 PMC6349152__F1 The role of SUMO in kidney fibrosis 7428 4089 4088 7046 PMC6349439__F1 We shall overcome (drug resistance) some day 238 6774 1956 PMC6349487__F3 TLR2, TLR3 and TLR9 regulate a robust immune response following HSV-1 infection 7097 54106 7098 29110 7189 3661 114609 4615 PMC6357482__F6 Schema of miR-21 regulated PTEN, PDCD4, SPRY2 pathway 4018 6935 10253 27250 5728 PMC6362810__F3 Multiple nonunidirectional levels through which autophagy-related processes in senescence affect regulation of SASP genes, often via NFkB activation 2626 2475 3586 3552 10758 PMC6366304__F2 Common nodes of resistance to targeted therapies within the PI3K pathway 5296 673 1956 5290 5163 5728 8821 PMC6366304__F3 Targeting the PI3K pathway in cancer with small-molecule inhibitors 3643 3667 5163 PMC6367888__F6 Gene-pathway network of 26 DEGs 3627 2633 3569 4599 3433 9636 8638 3437 91543 PMC6368395__F3 Immunosuppressive agent-induced cell-intrinsic tumorigenic pathways 3082 6774 467 2833 PMC6373781__F8 The interactions involved in the alteration of DC function following exposure to F 85451 9308 10333 7097 PMC6378284__F4 A schematic illustration of YAP/TAZ regulation of TE and ICM specification in preimplantation embryo 79923 1045 2625 PMC6386770__F1 Differences in the functional impact of IL-7/IL-7R-mediated signaling in T-ALL cells and their normal counterparts 3718 3716 604 2475 PMC6387347__F1 One proposed mechanism for how vascular endothelial growth factor/neuropilin (VEGF/NRP) signaling impacts cancer stem cell (CSC) function independently of VEGFRs 8828 5879 2735 648 PMC6396132__F3 Hedgehog signaling and Wnt signaling in the primary cilium 5727 6608 7976 1499 PMC6397695__F2 IDO1-Kynurenine-AhR signaling in TME immunosuppression 196 3458 3620 PMC6401303__F6 It’s complicated… m6A-Dependent Regulation of Gene Expression in Cancer 5728 56339 8835 51441 619501 PMC6406361__F7 Main steps of arginine metabolism 5009 4942 435 445 PMC6413705__F1 Complement dysregulation in complement-mediated HUS Complement activation initiated by any of the three pathways (classical, alternative, or lectin pathway) leads to C3 activation and C3 convertase formation on C3-opsonized surfaces 718 7448 727 2271 8526 7056 PMC6416297__F1 Reaction-based specification of the model according to the notation previously introduced 1719 635 27232 4548 10588 7298 4524 PMC6425874__F3 Protein networks around RXFP2 (red) 6019 111 2492 122042 11245 2782 554 4157 151306 117579 2696 339403 59345 2642 3640 2784 116 2783 51289 2641 PMC6428452__F8 p38gamma MAPK-promoted EMT 2066 2064 2625 23512 PMC6429030__F2 TLR2/IFN-λ3 protein-protein interaction was performed by using String software 6774 7097 3586 282617 3569 3572 3565 PMC6429226__F5 Apoptosis can be modulated by the activity of polyphenols in prostate cancer 355 8772 637 581 90427 572 638 317 735 730 729 717 718 PMC6430726__F7 Down-regulation of miR-543 expression increases the sensitivity of colorectal cancer cells to 5-Fluorouracil through the PTEN/PI3K/AKT pathway 5728 100126335 596 PMC6431020__F5 Schematic diagram of molecular mechanisms underlying PA-induced GC metastasis 2171 652995 6667 PMC6435069__F1 Complement pathways 718 717 721 727 1431 730 720 PMC6435069__F2 Complement regulators 718 717 4179 721 727 1431 735 720 730 PMC6442683__F3 Dendritic structural plasticity and neuropsychiatric disease 5662 9378 775 54413 10369 26047 2890 8573 288 785 1742 112476 2903 9229 85358 8831 815 816 4763 9459 7204 5879 8997 PMC6451008__F1 PTEN S-nitrosylation by NOS1 inhibits autophagy in NPC cells 4842 5728 2475 PMC6458269__F1 In response to various stimuli such as infection or injury, mucosal epithelial barriers express a range of signals that ILC2s can integrate 90865 85480 64806 7432 PMC6461560__F4 Phosphosites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT-mTOR signaling pathway in H3255 (left panel) and H1975 (right panel) 1950 2885 2475 57521 253260 6198 1977 1981 PMC6462522__F9 BIN1 loss enables ATM activation by the nuclear protein E2F1 1869 472 274 9656 PMC6466115__F1 Biosynthesis pathway of histo-blood group antigens (HBGAs) by stepwise addition of monosaccharides to precursor structures 2525 2524 2517 PMC6467375__F5 PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation 5140 7038 7959 PMC6476484__F1 Biological functions of IL-32 in inflammatory tumors 4318 4313 6366 2920 PMC6476865__F2 The PI3K-Akt-mTOR signaling by bioactive sphingolipids 1901 64781 1903 9294 6009 5066 PMC6482021__F2 Thyroid enlargement in patients with homozygous INSR mutation 3643 5163 3479 PMC6484083__F2 The inferred and enriched PPI network from 43 genes that sensitize yeast to Mn when deleted 1636 3991 27343 PMC6492912__F1 The nicotinamide adenine dinucleotide (NAD) biosynthetic pathways in mammals 203447 406 9575 952 93100 10135 PMC6501765__F3 Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) 8867 64768 10423 PMC6502894__F1 Diagram showing the main paracrine and dichotomic autocrine functions of the IL-6/JAK/STAT3 pathway in the pathophysiology of skeletal muscle 1756 6774 2191 PMC6504231__F8 Functional interplay of IL-21 with type I interferons in the response to MRSA 50615 920 6774 PMC6508148__F3 Proposed models of CST1 participating in the signaling pathways.Notes: CST1 was involved in GSK3, AKT, and IL-6 pathways 2932 1469 847 PMC6510479__F4 Epigenetic reprogramming of the innate anti-viral interferon response (IFN) 4615 5970 2146 6935 3659 PMC6511634__F8 Schematic illustration for the potential mechanisms of PC4 in AIPC progression 1499 999 1021 PMC6512360__F9 The type I immune response in M 3459 3458 6772 6773 3394 3659 3665 7054 4843 8530 1521 7124 10537 3003 3091 345611 100506742 840 4319 1513 PMC6514289__F1 Metabolic pathway of vicagrel and clopidogrel in humans 1559 1555 1557 1544 13 8824 PMC6522569__F2 Beyond PD-1 Immunotherapy in Malignant Melanoma 3902 3620 920 PMC6523516__F7 Molecular mechanism through which high glucose (HG) concentration promotes proliferation and migration in colorectal cancer (CRC) cells 3480 6714 891 PMC6524718__F4 The Nodal signaling cascade 5308 4838 7044 2657 PMC6528848__F1 Different regulatory mechanisms of BANCR in different human malignancy 2146 100885775 7253 4853 8841 999 1000 4312 4313 PMC6530347__F2 Overview of thyroid hormone (TH) production, transport, activity and regulation 3258 7067 7068 1733 1734 1735 PMC6533455__F1 Bone development and skeletal homeostasis 22943 50964 4040 4041 4038 6424 PMC6535773__F6 Dimensionality and the cell malignancy potential on lipid species amounts in the MCF10A breast cancer in vitro model 7038 2531 1674 5091 6611 PMC6537282__F1 New biologics and small molecules in inflammatory bowel disease: an update 7173 2056 50808 PMC6538180__F3 Transcriptional changes after herpes simplex virus type 1 infection in human trabecular meshwork cells 7040 57018 467 1847 1647 388 PMC6539837__F4 Intensity of information flow through the mTORC1-signaling pathway defines the fate of quiescent adult stem cells 3082 5728 7248 6009 7528 PMC6540260__F1 T-cell suppression and immune checkpoint blockage in tumor and organ rejection 324 941 942 940 2475 3718 PMC6548820__F10 The proposed mechanism for the indirect pathway of allorecognition in the T cell areas of the spleen and LNs 667 2829 7054 PMC6558469__F1 Mechanisms of tumor progression and tumor microenvironment‐mediated immune evasion in classic Hodgkin lymphoma (cHL) 920 9332 958 PMC6567082__F1 Crocus sativus extract affects the cell cycle by blocking the G2 and S phase via p53 and CyclinB-cdk2 proteins 993 994 995 596 581 PMC6567134__F8 Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation 948 2194 337 10554 116255 7038 23175 63924 1149 6720 PMC6577427__F1 NAD+ salvage pathway in mammals 203447 10135 952 PMC6581439__F6 Shown are the edges whose scores exceeded the threshold ; edges are labelled with their scores 1999 574414 55615 80742 878 2000 PMC6585451__F2 Gut mycobiota in immunity and inflammatory disease 112744 2475 1435 PMC6588588__F2 T cells are differentiated into multiple T cell subtypes including Th1, Th2, T-fh, Th17 and T-reg cells 6772 6775 6778 2625 30009 604 50943 PMC6588869__F1 Monolignol and ethylene biosynthesis pathways 790 57608 1312 PMC6590643__F4 Simplified figure depicting the roles of RORC consensus pathway members, adapted from Yu et al 59067 10538 51561 112744 6097 50943 604 7040 7054 6774 3662 5914 6513 8651 PMC6590809__F1 Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice 1581 1593 1582 9420 PMC6593428__F7 Model describing the mechanism regarding the inhibitory effect of IFITM2 on Type I IFN signaling pathway 29110 3661 10581 PMC6597102__F2 Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation 4049 3627 6347 3383 4055 727 1003 1499 5155 1000 5159 3553 6469 348 627 2668 PMC6606008__F2 Process of Hedgehog pathway begins on binding of specific ligands such as exo-secretion ligand Shh bind to the trans-membrane receptor PATCHED1 (PTCH1) it initiates the HH-GLI pathway 5727 6608 409 51684 2932 PMC6606335__F5 Phase I/II Trial of Carfilzomib, Pegylated Liposomal Doxorubicin, and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myeloma 572 8739 637 4975 PMC6606851__F10 Summary of the dominant effects of WNT5A mutations on skeletal morphogenesis 89780 7474 1499 PMC6608985__F15 Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFKB—IL-6 signalling axis 5879 3570 6774 PMC6610018__F2 Activation of the cGAS-cGAMP-STING pathway mediates obesity-induced inflammation and metabolic disorders 3661 115004 29110 PMC6610018__F5 Association of cGAS-cGAMP-STING signaling with apoptosis 29110 115004 3661 581 PMC6613812__F1 PI3K/Akt pathway plays a central role in nutrient-mediated cell proliferation and growth 5728 7249 7248 6009 8491 PMC6614373__F3 Signaling crosstalk at receptors and adaptors 7099 929 114609 3716 4615 8651 6772 PMC6618772__F1 Simplified metabolism of thiopurines in a target cell 7172 2875 8833 7038 PMC6626573__F6 Targeting of lung cancer stem cell self-renewal pathway by a small molecule Verrucarin J 324 1499 2305 7088 PMC6627216__F1 Synthetic lethality of PARP-inhibitors in HR-deficient tumors 672 472 11200 545 8030 PMC6627503__F2 Mitochondrial antiviral response 57506 3665 3661 PMC6627629__F6 Proposed mechanisms for fucoidan-mediated inhibition of osteoclastogenesis 5728 2932 4772 PMC6631168__F1 The Role of Wnt and R-spondin in the Stomach During Health and Disease 4040 4041 84133 54894 59352 8549 55366 2932 324 6657 6662 PMC6633015__F8 The signaling pathway mediated by GABAB receptor in CGN neuroprotection 3479 3480 6714 5266 PMC6639758__F3 An example of autocrine and paracrine interactions between NPY neuron (blue) and POMC neuron (green) in the ARC and their downstream effector neuron (i.e., neuron in PVN; beige) 4852 5443 4159 181 PMC6640082__F2 Heme Synthesis Metabolon 3145 212 10857 7390 2235 7389 5498 51522 1356 8803 PMC6649605__F8 Proposed mechanism by which gremlin regulates EMT and ECM protein expression in LECs 4087 4088 4089 4090 4086 PMC6663492__F1 Pathways that may impact radiosensitivity 1956 5728 2475 PMC6664200__F3 Type I-IV mechanisms which aberrantly activate hedgehog pathway in cancer 6608 5727 6469 PMC6693432__F5 Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis 5648 10747 3075 3426 710 8547 718 629 1675 717 720 1604 1378 5199 719 1380 1431 727 729 730 735 966 1191 7448 PMC6693703__F1 Mutation‐driven (ligand‐independent) activated Hh pathway in BCC development and invasion 5727 6608 2735 2737 2736 51684 847 PMC6697739__F6 An illustration of the bidirectional interaction between Th17 and BEC 920 1235 7124 196 6774 6364 3458 3717 PMC6705454__F8 Modulation of IGF-1R expression levels is sufficient to restore the AKT/CREB and ERK/Elk-1 intracellular signaling pathway activation profile, resulting in SMN expression increase in SMA mice 3480 3479 2002 6607 PMC6707713__F4 Interplay between DNA tumor viruses and the host DNA damage response 472 672 165918 3014 PMC6711563__F3 Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole 2475 6662 595 6608 1499 6469 4363 5727 PMC6713920__F3 The schematic flow of biosynthetic pathway of DNJ in S 133 717 729 PMC6715524__F4 Summary of histone PTM-mediated 53BP1 and BRCA1 DSB repair pathway choice regulation 672 165918 3065 3066 580 26013 54799 PMC6721756__F7 Role of distinct STAT2 and/or IRF9-dependent pathways in the regulation of distinct subset of antiviral and immunoregulatory genes in response to IFNB and TNF 3716 7297 6772 PMC6722206__F1 miRNAs orchestrate T cell metabolic reprogramming 1374 2475 100034703 PMC6726984__F2 SnoRD126 activates the PI3K-AKT signaling pathway through FGFR2 and snoRD50A/B and affects the MAPK signaling cascades 100113391 5164 4609 1869 2263 PMC6728077__F1 DCs modulate Tfh-2 responses through the IL-6/STAT3 signaling pathway 6774 2625 643 PMC6732511__F2 Optimal management of atypical hemolytic uremic disease: challenges and solutions 718 629 3426 3075 7056 10878 3078 3080 5340 727 64423 729 PMC6737310__F4 Inflammatory mediator network between cytokines and signaling pathway in liver fibrosis 6774 3586 50616 3569 PMC6743726__F2 Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis 4397 635 875 PMC6744284__F7 Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the glomeruli 2520 2475 3458 929 2353 PMC6745947__F1 Hepcidin regulation by iron and erythropoiesis 2056 7018 650 654 151176 148738 3077 164656 7036 4086 PMC6746704__F8 Elevated FAM83A expression in pancreatic cancers is driven by a MEK/ERK-JUNB-driven feed-forward signalling loop 3845 84985 637 2354 1958 3726 PMC6747410__F1 Signaling pathway of DNAM-1 receptor 2534 7409 5336 PMC6755182__F8 Ginsenoside Rb1 prevent the steroid-induced avascular necrosis of the femoral head through BMP-2 and VEGF signaling pathway 5925 650 860 PMC6755815__F6 The pathway by which LPA increases LPP3 expression 4099 4018 5970 5971 PMC6760157__F6 Cystathionine Beta-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter 875 212 2235 2056 2057 3717 PMC6768886__F7 MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/Beta-catenin signaling 7052 8324 1499 2113 51176 4040 4041 PMC6770250__F1 Basics of transforming growth factor B (TGFB) signaling 4088 4087 6497 4089 PMC6770582__F6 Schema of the present study 79365 59350 2526 140688 144402 5644 PMC6771225__F3 Rational combinations of PARPi with other targeted agents 494551 920 3661 1956 115004 367 2475 PMC6771534__F2 Evasion of the IFN‐I signaling pathway by HSV1 7097 54106 7098 115004 3661 29110 PMC6772062__F1 Canonical Wnt/B‐catenin and divergent signaling pathways 4040 4041 324 2931 2932 2475 1499 51176 PMC6774117__F10 NGF-driven differentiation of PC12 cells requires a signal(s) generated from the UPAR immediate-early gene product 4803 5091 1958 PMC6775198__F1 Role of Wnt Proteins in T cells 6778 920 50943 PMC6776600__F1 Overview on complement activation and cascade progression 1356 718 728 727 27202 PMC6780840__F3 Intracellular peptidoglycan (PGN) is detected by intracellular receptors and activates the NFKB signaling pathway in Drosophila melanogaster and human enterocytes 7186 8767 23118 331 5966 PMC6781400__F7 Schematic illustration of the role of CyclinD1 to regulate Dicer promoter in ICC 595 1021 1019 PMC6784892__F4 Two intracellular and cell type-specific bacterial symbionts 346007 100187907 759 PMC6788940__F2 Targetable pathways in ESR1 mutant cells identified in preclinical studies 3479 3480 2475 1017 1022 PMC6795678__F1 Scheme of the parietal cell of a gastric gland 759 846 885 PMC6797170__F7 Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach 2155 5345 5340 2153 2158 2152 7450 2157 7035 2159 5054 7056 462 5265 2 2160 2147 PMC6798880__F2 Oncogenic KRAS effector pathways 2621 558 2885 3845 5899 29110 2475 PMC6800286__F7 The pathway leading to IL-1B release from NK92 and its inhibition by DMF or MMF 3553 1788 1789 79792 PMC6807343__F8 Proposed model 3553 3569 3667 7124 PMC6810856__F10 Rhinovirus -induced SIRT-1 via TLR2 regulates subsequent type I and type III interferon responses in airway epithelial cells 7096 10333 7097 6772 6773 10379 23411 3661 PMC6813538__F8 Action of EC-7072 targeting the BCR signaling pathway in CLL cells 930 973 4067 695 5336 8915 10892 596 PMC6813721__F7 Inferred role of ACSL1 in sepsis 2180 7124 3458 2182 PMC6818723__F14 Hypothetical signaling network integrating top genes identified through Rasch analysis 348 10154 5621 3688 846 5747 50863 2534 2395 632 23237 4193 7157 64782 8841 2475 57521 PMC6826129__F7 Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) as a central mediator of vascular aging 634 50507 7046 PMC6826509__F4 Influence of high CO2 concentration on hormone and stomatal regulation 3652 1362 340451 4015 1431 PMC6832489__F1 Wnt/Beta-catenin signal transduction pathway in homeostasis 4040 4041 8312 2932 324 1499 8313 PMC6832489__F2 Schematic view of sex determination 54361 284654 6662 6736 7536 7490 2254 268 PMC6834079__F1 The Hedgehog signaling pathway and depiction of key regulatory interfaces 6608 64399 5727 374654 51684 91653 2736 PMC6834161__F2 Working model of FH physiopathology and the effects of CoQ 3949 255738 19 PMC6844627__F4 Mapping Biological Networks from Quantitative Data-Independent Acquisition Mass Spectrometry Proteomic Data: Data to Knowledge Pipelines 2597 25932 2027 7139 3329 7137 1410 2170 11155 7431 54205 2318 1845 7316 PMC6850218__F1 Model illustrating 4 potential roles of RGD-binding integrins in the initiation, development, and perpetuation of organ fibrosis 7049 4089 4087 4088 PMC6851264__F8 Working model of the pathway to maturation of invadopodia when cancer cells are stimulated by transient tugging forces 5879 5058 3984 PMC6855178__F1 Action of Targeted Therapies in Metastatic Renal Cell Carcinoma 2621 3082 5979 558 7428 2475 PMC6857441__F7 Schematic overview of the pathways linking glucocorticoids and their precursors to their urine metabolites 3291 1584 1589 3290 PMC6859457__F7 The HPV18 pathway regulates Tim-3/galectin-9 through EZH2-H2K27me3-DNMT3A 2146 3965 1788 84868 PMC6876670__F2 Canonical WNT/Beta-catenin pathway: “on” and “off” states 22943 4040 4041 324 2932 1499 595 PMC6879860__F3 Schematic of the components of the integrated model 1392 2475 2922 11113 4118 PMC6880928__F1 Splicing the innate immune signalling in leukaemia 7307 51135 4615 PMC6882186__F10 Proposed pathways for polysaccharide biosynthesis in Dendrobium moniliforme 2582 101448070 2762 2821 4351 PMC6883840__F1 The pathway for synthesis of PLP in E 6668 6667 7068 6670 8566 PMC6883840__F10 Proteins and metabolites in JK1 that change by >2-fold relative to wild-type E 22934 6120 2597 PMC6885792__F3 Role of MYOF in EGFR-related pathway 1950 1956 26509 6722 PMC6888741__F4 DUBs and their role in Hippo signaling 9113 26524 83737 27005 55432 220213 154796 8239 78990 9686 8237 PMC6891791__F4 Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol 7124 5053 2475 6476 4117 5066 PMC6892740__F4 Major phospholipid biosynthetic pathways, genes involved, and subcellular localization of the encoded enzymes.PTDSS1,PCYT1A, andPISD from this study (all in red font) are associated with syndromic skeletal dysplasias 55224 5833 1120 1119 9468 5130 56994 10390 10400 5091 9791 23761 81490 PMC6895153__F5 Hormone-related pathways enriched in DEGs of the brain and gonads 2492 5617 3973 100188864 7253 7168 2690 5618 6770 1583 1586 1588 PMC6895510__F1 Regenerative abilities contribute to the application of BM-MSC in psychocardiological disease 4851 2296 2303 2147 7450 2670 PMC6901958__F1 HSV-1 mediated evasion of the DNA-sensing pathway in innate immunity 3455 7297 3428 115004 29110 3661 10379 3437 9023 27040 3181 6773 PMC6905042__F1 The Wnt/Beta-catenin signalling pathway 2932 1499 324 PMC6905101__F5 Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling 6714 3717 6774 PMC6906582__F1 Toll‐like receptors (TLRs) and their downstream signaling 3665 3661 7097 PMC6912965__F1 Underlying mechanisms of Tregs in PAH 595 659 387 PMC6915875__F6 The mechanism of AML cell-secreted exosomal miR-4532 in hematopoiesis of HSCs 23641 6774 22943 PMC6920888__F8 The anti-melanogenic mechanism of PS and PTS 4157 5805 4286 PMC6920895__F5 The metabolic network and key enzymes in Aurantiochytrium sp 2539 355 65057 PMC6924059__F4 ARHGAP9-mediated regulation of the MAPK signaling pathway in BC 1950 1956 64333 PMC6924635__F1 Exosome biogenesis and major exosomal cargoes 967 975 100170220 5873 5874 928 3732 PMC6927050__F8 Schematic diagram of hypoxia-induced pyroptosis in myoblasts 79792 5081 114548 PMC6928633__F3 Constructed metabolic pathway that integrated relative metabolite contents and gene expression for three different sizes (small, medium and large) of beech mushrooms 6965 847 100187761 PMC6932950__F1 An overview of current and emerging agents for TNBC therapy 6469 2475 5727 1019 6608 1719 672 PMC6933397__F5 Molecular mechanism by which NKILA regulates osteogenesis 105416157 59350 3066 PMC6940904__F1 Overview of the complement cascade and principal complement targeting molecules 718 2271 721 4155 727 1378 966 730 729 735 PMC6942871__F6 The main targets of miR-221/222 involved in ovarian cancer 9021 2771 5728 378 90427 6774 PMC6947886__F3 Differentially expressed genes in the estrogen signaling pathway 596 5447 7018 759 PMC6949069__F6 The breast cancer pathway 675 5728 3815 PMC6955834__F4 Intermittent fasting‐mediated pathways that induce adult hippocampal neurogenesis 4851 388585 627 PMC6959052__F7 Working model of the role of IL-6/STAT3 pathway on hypoxia promoting HCC progression after TACE 6774 8178 6615 619501 PMC6959074__F3 Roles of sirtuins may be involved in nicotine/nAChR-mediated signaling pathway 22933 23411 51548 23410 23409 23408 1136 1143 1138 51547 PMC6959903__F6 MiRNA-mRNA regulatory networks in adenoid cystic carcinoma (ACC) 983 9133 54443 1063 7153 PMC6966641__F1 Major pathways involved in muscle loss in cancer cachexia 2475 4087 4615 PMC6966713__F5 Linear ubiquitination and NFKB activation 7124 7099 8717 4615 7186 7188 3656 51135 3654 7189 81858 64127 8767 331 8737 PMC6971992__F2 ZIKV-induced ER stress initiates host cell unfolded protein response (UPR) 22926 7494 83939 468 9695 79094 467 PMC6976902__F1 miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo 6608 2735 2736 PMC6976905__F1 Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/Beta-Catenin Signaling Pathway in GC 8322 1499 100128893 2146 595 PMC6982012__F2 Conversion into myofibroblasts from quiescent fibroblast involves mechanical and paracrine activation of profibrotic pathways 4089 4087 4088 PMC6997700__F1 Leaf lipid pathways and hypotheses for acyl flux into TAG 4018 5091 355 PMC7004522__F8 Working model shows that MET inhibitor inhibited the positive feedback loop between high STMN1 hepatocellular carcinoma (HCC) cells and hepatic stellate cells (HSC) 3082 3925 619501 PMC7008497__F3 Signals 1 and 2 for nod‐like receptor protein 3 (NLRP3) activation may be delivered by cGAS or TLR9 3553 115004 54106 PMC7015808__F1 Steroidogenic pathway with oxysterols followed in this study.Abbreviations: CHEH – cholesterol epoxide hydrolase, CH25H – cholesterol 25-hydroxylase, CYP – cytochrome P450, DHCR7 – dehydrocholesterol reductase, ROS – reactive oxygen species 1581 1717 9023 1593 PMC7016599__F2 Some of the signaling pathways regulated by integrin A6B4 in colorectal cancer cells 274 324 2932 1499 4609 3691 4149 PMC7018661__F6 The epithelial–stromal interactions in the tumor microenvironment of GC 9839 90865 6667 PMC7022396__F3 Metabolic pathways involved in the de novo synthesis from sugars of floral esters by H 1121 5548 3030 PMC7024062__F1 CS response 718 717 727 721 PMC7024175__F1 CAMKK2 signaling pathway 10645 8536 814 PMC7026586__F7 TP53BP1 and associated genes are downregulated in prostate cancer 7158 165918 9025 55183 672 PMC7029263__F1 Wnt/Beta-catenin signaling cascade in Parkinson's disease 4040 4041 2932 324 1499 51176 PMC7029263__F2 TRPV1-CNTF signaling cascade in PD 7442 1270 6774 PMC7033644__F2 EV trafficking between leukemia and stromal cells reduces sensitivity to chemotherapeutics 5091 3579 9242 3577 650 PMC7035994__F1 Apico-basal polarity proteins play a critical role in homeostatic control of cell density 6418 9231 3996 3993 4140 64398 4139 2011 57787 10207 PMC7043073__F3 Impact of co-mutations on the microenvironment of KRAS-mutant lung adenocarcinoma 4609 9817 7157 PMC7046304__F8 SPAG5‐AS1/miR‐769‐5p/YY1‐positive feedback loop transcriptionally induced SPAG5 and SPAG5‐AS1 interacted with USP14 to induce de‐ubiquitination of SPAG5, so that AKT/mTOR signalling was activated to inhibit autophagy and induce apoptosis in podocytes 7528 100506436 10615 9097 2475 PMC7047232__F6 Cartoon presentation of proposed cellular and molecular mechanisms for the synergistic effects of ATO/AA combination treatment 596 3553 842 PMC7052940__F1 FGF/FGFR signaling pathway involved in resistance to oncotherapy 6774 1956 595 4255 PMC7053872__F5 Potential pathway of NAFLD development 4025 1579 3553 PMC7056524__F1 In normal B cells, Mir-15/16 target Bcl2 572 596 7474 581 PMC7058049__F9 Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation 860 9358 7128 PMC7064362__F5 Inhibitory Effect of Rosae Multiflorae Fructus Extracts on the Receptor Activator of NFKB Ligand-Induced Osteoclastogenesis through Modulation of P38- and Ca2+-Mediated Nuclear Factor of Activated T-Cells Cytoplasmic 1 Expression 6850 7189 7006 100124696 695 29760 2353 4772 PMC7068130__F8 Molecular Mechanism of Loss of Function of TLR9 Might Play a Major Role for NPC Susceptibility in Specific Ethnic Groups of NE IndiaSome populations, called “mongoloids,” show a significantly higher incidence for NPC 54106 51316 63976 5359 7350 PMC7068780__F4 Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis 3107 4609 55937 246778 PMC7069516__F14 Interrupting cyclic dinucleotide-cGAS–STING axis with small molecules 207 115004 29110 3661 PMC7072680__F1 gp130 cytokines and receptors activate downstream signaling pathways 3976 5008 1270 3977 9180 1271 10148 PMC7072933__F1 Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma 2475 7249 7248 6009 619501 PMC7073546__F4 Synthesis of capsaicinoids adapted from Mazourek et al 1312 275 1431 PMC7077606__F1 SFRP5 at the crossroad between obesity, T2DM and CHD 6425 7474 6010 4920 PMC7078296__F7 Helicobacter pylori-induced adrenomedullin modulates IFN-Gamma-producing T-cell responses and contributes to gastritis 175 10266 6774 133 PMC7082774__F1 Emerging roles for branched chain amino acid metabolism in cancer 152926 2475 47 PMC7086357__F8 Proposed model depicting the molecular mechanism by which Serelaxin activates Notch signaling pathway to inhibit TGFBeta-induced SMAD2/3 phosphorylation to restore the RXFP1 expression via histone modifications 7040 59350 4087 4088 PMC7092476__F6 Signaling pathway enrichment analysis of core targets of TWH for CD 7124 8772 7054 6955 PMC7098960__F2 The immune response induced by polygenic diseases related to the composition of the intestinal microbiota in patients with IBS and healthy subjects 7097 7297 114609 64127 51284 6774 7189 149233 4249 3587 3594 PMC7106881__F9 Hypothetical action mechanism of aspirin on nonalcoholic fatty liver and atherosclerosis 729230 355 3156 PMC7109575__F1 Role of the Wnt/Beta-catenin signaling pathway in chemoresistance of colorectal cancer 2932 324 1499 4316 355 PMC7110972__F7 Proposed rES/ID1/TSP-1 signaling pathway 961 948 3397 PMC7142254__F3 Targeting USP7-MDM2/MDMX-p53 network for cancer therapy 7874 10020 4193 PMC7144730__F5 EVO downregulates HGF-induced c-Met/Src/STAT3 phosphorylation and causes apoptosis through blocking the c-Met signaling pathway 3082 6714 6774 PMC7147542__F2 Sonic hedgehog (SHH) pathway 6469 6608 51684 PMC7158685__F1 Main immunological pathways in human antigen presenting cells (APCs) after mycobacterial RNA recognition 7098 51311 4615 324 3661 3663 3553 3458 PMC7168513__F1 Cytosolic DNA‐sensing immune response via cGAS/STING 115004 29110 11277 3661 PMC7169117__F2 Schematic illustration of the major HCV proteins and corresponding targets, by which HCV modulates the TGF‐B signaling pathway 64750 4088 5728 PMC7169117__F6 Schematic illustration of the major KSHV factors and corresponding targets, by which KSHV modulates the TGF‐B signaling pathway 7057 4090 4087 PMC7169117__F8 Schematic illustration of the major SARS‐CoV proteins and corresponding targets, by which the virus modulates the TGF‐B signaling pathway 4088 6774 1958 PMC7179138__F5 Schematic diagram illustrating the mechanisms of A 8717 8772 572 637 581 331 PMC7180609__F7 Glutamine-dependent metabolic pathways in T 3034 5625 8833 4553 PMC7181472__F6 Mechanism of side effect caused by Tripterygium hypoglaucum hutch and the mechanism of alleviation compensated by the rest of herbs 4843 440 5471 3615 5978 PMC7190864__F4 Comparison of significant canonical pathways and upstream regulators in monocytes infected or non-infected with Mtb UT127 and UT205 isolates 1959 3146 7099 5196 7097 54210 929 2022 126014 958 6404 7054 5743 7124 959 1431 5979 7295 54738 9370 6010 PMC7193415__F8 GR Ser134 phosphorylation creates a feedforward signaling loop that potentiates further activation of the p38 MAPK pathway downstream of TGFB1 in TNBC models 4088 4087 4089 468 7071 113791 7044 PMC7195637__F7 Regulation of mTOR on Th9 cell differentiation 64798 3091 3662 2308 PMC7198545__F8 TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination 80342 57506 29110 7187 3661 PMC7203229__F3 Genomic competition for noise reduction shaped evolutionary landscape of mir-4673 1499 6929 6925 7020 7022 7021 594857 10664 PMC7205036__F11 Scheme summarizing the mechanism of the protective effect of astragalin and CGA on E 1081 929 4615 51135 7189 3654 3656 3553 PMC7210388__F1 GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17 9248 6868 9794 6667 619501 PMC7210546__F2 TLR4 signaling pathway in the DN on the basis of literatures 7099 114609 4615 7189 3661 PMC7211957__F7 Model illustrating the Thbs1/integrin/YAP signaling pathway in remodeling of vessel walls 7057 9113 26524 PMC7214175__F7 Proposed model of metformin‐induced activation of the Hippo pathway in drug‐sensitive and drug‐resistant breast cancer cells 122786 4771 23513 PMC7215894__F1 KLF11-mediated modulation of the TGFB signaling pathway in normal cells and tumors 7046 4089 25942 8462 PMC7218026__F6 Schematic presentation of the ACLY PIP2 binding region and the novel Lyn/Src-dependent tyrosine phosphorylation sites 4067 6714 47 PMC7230049__F1 Rationale for homocysteine removal by the administration of a full array of activated micronutrients 1719 5212 4548 4524 635 4552 55349 875 PMC7230796__F1 Metabolic pathway of vitamin D (based on Jenkinson 2019 and on Feldman et al 1717 1593 120227 1576 1591 1594 7421 PMC7230958__F1 Summary of the metabolic pathway for n-6 and n-3 polyunsaturated fatty acids 1896 2717 100 PMC7231511__F1 MHC cross-dressing can promote interaction between helper or regulatory CD4+ T cells and effector T cells 920 7054 324 PMC7232129__F7 HBV-miR-3 activation of innate immunity to restrain HBV replication 6772 4599 4938 3437 3433 3454 PMC7235440__F1 Herpesvirus host shutoff-associated proteins mediate evasion of the type I IFN signaling pathway (refer to ) 115004 3428 57506 4615 7189 7187 29110 3665 3661 6773 54106 7097 7098 PMC7236211__F1 Pathway engineering strategy for succinate production in S 11113 5183 6390 4118 PMC7246474__F2 Summary of proposed pathogenic mechanisms in TRAPS 7124 8717 8737 7186 7188 PMC7246584__F1 Interplay between HCV-induced oncogenic signaling pathways 1956 1950 975 9076 5789 4088 619501 6774 9021 PMC7248557__F4 Alteration of TLR4 signaling in pregnancy disorders 4615 7099 7187 3661 PMC7249489__F3 Signaling Pathways in Leukemic Stem Cells 2932 324 1499 4040 4041 PMC7249724__F3 Micro-environment favorable for re-pigmentation 5091 4157 4089 5077 4286 PMC7251091__F8 Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway 7803 8204 51050 6667 4313 4318 PMC7254656__F2 Main signaling pathways involved in CD19-BBζ T cells and CD19-28ζ T cells 652070 940 3383 PMC7255038__F3 Schematic diagram representing interplay between metabolism and epigenetics 8473 23411 51548 4200 10873 4199 PMC7258638__F1 Can respiratory syncytial virus (RSV)-dependent necroptosis be targeted for therapeutic benefit? Simpson and colleagues demonstrate that RSV infection readily induces necroptosis in RSV-infected airway epithelial cells 57762 8737 197259 11035 64806 85480 342538 90865 3146 2625 7099 PMC7260729__F8 RAP2.3 negatively regulates nitric oxide biosynthesis and related responses through a rheostat-like mechanism in Arabidopsis 314 8639 26 PMC7265991__F1 Intersection of radiation and the tumor immune microenvironment 115004 3146 948 PMC7266663__F7 Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway 6476 7189 4772 PMC7268490__F1 Schematic diagram of experimental workflow 4397 5327 5972 PMC7269828__F1 Predictive biomarkers for PARPi efficacy 675 2175 5890 11200 79728 472 51755 PMC7275785__F1 Hyperprogression to a dual immune blockade followed by subsequent response with cabozantinib in metastatic poor-risk clear cell renal cell carcinoma with NOTCH mutation 2885 5728 5879 2475 3280 PMC7279407__F2 Simplified diagram of the core element of the three unfolded protein response (UPR) signaling branches of the endoplasmic reticulum (ER) 22926 83939 7494 468 PMC7279457__F2 Positioning Cx43 in the intercellular coupling by channels in the DC-T cell IS 941 942 24145 324 940 920 PMC7280066__F1 Regulatory functions of oncogenic and tumor suppressor long non-coding RNAs (lncRNAs) in the Wnt/Beta-catenin signaling pathway attributed to the pathogenesis of non-small cell lung cancer (NSCLC) 652995 23642 100124700 6662 283131 140828 22943 84791 6423 6657 100507056 324 154860 55384 387111 100507632 554202 554203 1499 730101 618 7503 654434 6659 84793 541471 PMC7281461__F2 Primary pancreatic cancer recruits fibroblasts to become cancer associated fibroblasts (CAFs) 471 27122 2191 309 PMC7282166__F1 Protein-protein network of the 186 exposure genes 4397 133 1191 2774 127833 5901 6590 5008 10135 1844 2995 PMC7283441__F1 Signaling cascade of apoptosis in traumatic brain injury (TBI) 355 572 637 581 2021 PMC7284928__F2 Protein-protein connection networks among the eight genes involved in PPARG-MI signaling pathways 5468 4615 34 5970 PMC7285260__F6 N starvation and disruption of cyto-nuclear coadaptation on allantoin synthesis and degradation 8833 50802 391051 PMC7288517__F5 Shortest paths for enrichment analysis of KEGG and BP 2712 23305 2168 604 2170 8837 3594 10678 64919 50943 PMC7292335__F1 Cbl-B in T-cell activation 3558 940 1493 920 PMC7295575__F5 Summary of the proposed pathway 9780 342538 102 4851 PMC7299226__F6 Metabolic pathway showing lysoPL (lysophosphospholipids)/lysoPA (lysophosphatidic acid) regulatory genes that are significantly altered by ANRIL knockdown in HEK cells.Genes that metabolize these lipids are shown 5091 8605 57104 79888 54947 129642 10162 23305 5168 7941 3931 8611 1606 79887 8612 64748 PMC7302136__F9 LncRNA LINC00314/miR-129-5p/GRM5 in osteogenic differentiation of ADSCs 1499 246705 2915 PMC7303082__F6 Adenosine affects the B cell receptor pathway 6850 5336 695 84890 PMC7304108__F8 Proposed model by which hsa_circRNA_102610 promotes growth and transforming growth factorB1-induced epithelial-mesenchymal transition of intestinal epithelial cells by sponging hsa-miR-130a-3p 4089 1000 595 999 PMC7306315__F1 Iron homeostasis and signaling pathways involved in hepcidin regulation 2056 151176 148738 57817 PMC7306774__F7 Proposed mechanism for CRY’s effect on susceptibility to stress-induced depression-like behavior 4280 8864 2353 PMC7307178__F8 Current model for the suppressive effect of MERS-CoV N protein on the RIG-I-induced type I/III IFN expression 7706 3661 3659 PMC7307818__F7 Possible mechanisms responsible for the effects of paeonol against human colorectal cancer HCT116 cells 595 8312 1021 1019 1499 2932 PMC7309952__F6 Regulatory network of the BCL2 family in gynaecologic and breast cancer 5447 7157 5290 4609 637 638 581 598 PMC7311199__F3 DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer 115004 9447 79792 3661 29110 114548 1687 8737 11035 197259 PMC7318302__F1 Correlation of Notch signaling pathway and ER in breast cancer endocrine resistance 1956 3045 100187828 4162 PMC7325493__F1 Complex Signaling Network Driving Macropinocytosis in Cancer 1956 4040 4041 5879 1499 5728 PMC7328520__F6 nc886 and cancer 4609 6774 3717 83939 PMC7330693__F8 GINS2 interference induces apoptosis and cell cycle arrest 51659 595 1019 PMC7339281__F2 METTL3 regulates cell proliferation 693185 56339 100423026 1956 10642 27125 4609 1499 51176 29028 5728 54487 PMC7339281__F3 METTL3 regulates cell apoptosis 7942 56339 3184 6469 2259 79755 PMC7346972__F1 Insulin growth factor pathway and its relationship to intracellular signaling molecules 3480 572 2475 2549 PMC7347234__F7 System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion 907 100379198 1723 5091 PMC7350315__F4 ATR signaling pathway is involved in the HPV life cycle 11073 1869 545 6241 2177 2626 PMC7352245__F3 Canonical and alternative NFKB signaling pathways 613 958 4055 4067 329 330 695 6850 7186 7187 84433 8915 4790 5970 5971 973 974 PMC7352466__F2 Biological effect of PARPi on cancer cells 3627 6352 29110 3661 115004 PMC7352588__F3 DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer 7316 7311 7314 PMC7356809__F3 FAT10 is expressed in response to RNA virus infection and acts as a negative feedback regulator of RIG-I activation 57506 1283 7186 7189 7187 3661 3665 PMC7359092__F1 Recent discoveries on the protective role of IL-22 against tissue injury 130120 26291 595 596 6774 2475 PMC7360675__F1 Extracellular and intracellular regulatory mechanisms of HLA-G expression 3135 1438 3659 PMC7367634__F1 MAPK and PI3K‐AKT‐mTOR signaling pathways 673 3490 2475 PMC7367634__F6 Resistance mechanism to vemurafenib 4893 4763 2475 5728 PMC7368941__F6 Function of podocyte injury is closely related to morphological changes 23411 2475 8408 9706 PMC7375918__F4 Emerging Functions of Lactate in Regulating Signal Transduction and Gene Expression 57446 7428 57506 29110 3661 PMC7379270__F4 The NF‐KB pathway 7124 4803 8717 7186 7188 5970 PMC7379485__F7 ALDHHIGH cells regulatory mechanisms in cervical cancer cells 4040 2932 1499 PMC7382367__F3 Role of methyltransferase-like enzyme 3 and methyltransferase-like enzyme 14 in urological cancers 56339 1499 51176 3688 595 PMC7382747__F3 Relevant signaling pathway in itaconate-induced anti-inflammatory and antioxidative effects 790 467 2152 9817 2597 226 3603 PMC7383642__F1 Reported coagulation pathway variations in African Americans 7450 5340 2224 PMC7388413__F1 The PI3K pathway in cancer cells 1956 5266 2475 PMC7390945__F4 Some involved pathways in C8- and C10-treated cells, on the basis of Metabolic Pathway analysis 47 355 2744 PMC7393201__F7 Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1A pathway 152831 26291 2260 581 3553 7045 PMC7393494__F7 Inhibition of miR-1193 leads to synthetic lethality in glioblastoma multiforme cells deficient of DNA-PKcs 100422837 545 7528 2237 PMC7407180__F5 Proposed biosynthetic pathway leading to terpenoids in A 4598 3652 5640 PMC7408575__F2 JAK-STAT canonical signaling pathway 29949 11009 2056 7173 PMC7408754__F2 Gas6/Axl signaling promotes the immunosuppressive tumor microenvironment 920 6348 6351 6347 PMC7415309__F7 Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/Beta-Catenin Axis 102723356 100188771 3198 1499 PMC7419046__F2 TGF‐B signaling regulates lncRNA expression and mechanisms of TGF‐B signaling control by lncRNAs 4087 4088 4089 728463 55000 399959 79854 5494 PMC7419058__F1 P53 activity by FBXO22 during senescence 51230 9682 26263 PMC7425726__F9 Proposed regulatory pathway for FGF2 mediated mesenchymal transition in human corneal endothelial cells 2247 6935 6670 6667 7431 2335 PMC7427467__F5 IL-27 tips the balance of immunity toward L 6347 3586 7124 3458 920 PMC7431397__F2 GPCR-mediated proinflammatory signaling via signalosomes and endosomes 10892 8915 1540 23118 10454 PMC7431833__F6 Schematic diagram depicting the possible mechanisms 23621 351 22933 PMC7439102__F4 Signaling pathway diagram 367 472 545 5728 5371 2765 5111 PMC7440025__F2 Major antiviral functions of TRIM proteins 373 7706 7726 117854 10155 23321 9830 90933 PMC7446622__F1 Inflammation during SARS-CoV-2 infection.SARS-CoV-2 invade host cells with angiotensin-converting enzyme2 (ACE2) receptors present on the cell surface membrane 114548 7099 4615 PMC7446622__F3 Glycogen synthase kinase-3: A putative target to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic 7018 7099 7450 PMC7447312__F7 Working model 7421 6775 920 PMC7450103__F1 Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target 7808 10606 2618 5198 471 5471 158 PMC7452942__F2 Soluble protein sensors built by means of bottom-up approaches 652070 7018 100187761 2260 PMC7456455__F1 Monocytes represent a window between bone marrow and tissues 929 958 1436 1441 3458 PMC7457075__F7 Possible mechanism of anti-inflammatory effect of OEA on colitis 5465 7186 3553 PMC7458277__F5 Interaction network derived from the pathway analysis according to results of the genome-wide association study [GWAS] meta-analysis 2043 10368 10253 7903 4685 1311 4855 5336 958 23225 1856 11260 6196 6517 1054 8320 7204 3274 4158 PMC7462039__F2 Engineering Brain-Specific Pericytes from Human Pluripotent Stem Cells 7048 238 4092 7448 4087 4089 1000 7422 1499 4088 4090 4086 PMC7464802__F3 MOMP-induced signaling activation in tumor cells 24145 115004 581 1687 3553 PMC7469327__F6 Drugs targeting inflammasome signaling in MS and EAE 114548 22861 6772 6774 3553 PMC7471657__F3 Gene ontology terms and KEGG pathways 968 3569 54474 50943 29126 925 5133 920 917 931 916 915 919 6622 9825 5788 PMC7472700__F3 T-MPs function 941 115004 942 PMC7473503__F2 Androgen receptor pathway inhibitors and their mechanism of action 140805 1586 367 PMC7483234__F3 Correlation of multiple markers of cell death signaling pathway in the hippocampal dentate gyrus (DG) of postmortem AUD human brain 8718 8717 355 PMC7485347__F3 Functional and clinical significance of INI‐1/SMARCB1 6598 595 1499 PMC7486896__F8 Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/Beta-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma 1499 6667 4316 4313 PMC7495093__F7 Pyroptosis of acute kidney injury (AKI) signaling and protective effect of SalB through the nuclear factor erythroid-2 related factor 2 (Nrf2)/NLR family pyrin domain-containing 3 (NLRP3) pathway 10628 114548 79792 PMC7503842__F1 Wnt signaling pathways 1499 4040 4041 2932 324 387 5879 51701 3725 PMC7504541__F9 Hypothetical role of IL-6 in oncogenesis and tumor-associated thrombocytosis 6868 7173 6774 PMC7507458__F2 Links between lncRNAs and Hippo signalling cascade 4485 11186 110599565 641518 9113 497258 399959 100874185 102723099 148189 100499467 10733 285908 103695431 283422 114004396 618 100192378 285958 7503 441951 55000 64002 PMC7508434__F5 Diagram for the molecular mechanism 6774 3717 9547 PMC7509237__F6 Model highlighting the identified dual role of GPS2 during human adipocyte differentiation 652 4023 9619 2874 PMC7509716__F1 Proposed mechanism for enhancing antigen‐specific immune response by the CS‐IONzyme‐based influenza vaccine 3725 958 941 942 3603 PMC7516013__F2 Farnesoid X receptor (FXR) regulates bile acid (BA) synthesis in a tissue-specific manner 1582 1581 2264 9965 PMC7517787__F8 Mechanism model of exogenous MT in delaying the post-harvest decay of wax apples 847 4015 2054 PMC7520847__F4 Hedgehog pathway 6608 6469 2736 2737 2735 51684 PMC7521313__F7 Mechanism of danshen on heart failure is mediated by MyD88‐dependent TLR4‐TRAF6‐NF‐KB inflammation pathway’ 7099 7189 5970 PMC7521342__F5 Global gene expression analyses of the alkamide-producing plant Heliopsis longipes supports a polyketide synthase-mediated biosynthesis pathway 4299 2334 3899 27125 PMC7522266__F2 Bifidobacterium longum subsp 2582 101448070 2821 7086 PMC7524949__F2 Synthesis, release, and metabolism of intra- and extra-cellular purines 84890 100 4860 PMC7526732__F4 Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women 124857 155465 5589 10631 4059 5195 8412 1990 63036 1474 93185 1576 3483 2799 1949 2160 PMC7527574__F1 Therapeutic targeting of HGF/c-Met pathway 3082 558 6714 2475 572 PMC7527722__F7 Klebsiella pneumoniae ablates SUMOylation via distinct pathways in epithelial cells or macrophages 1956 7099 59343 2932 4738 PMC7528619__F2 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 51428 3428 115004 1499 3661 PMC7531836__F1 Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease 718 1378 2271 727 729 730 735 966 PMC7539779__F6 Mechanism by which SLFN5 regulates BRCA progression 162394 6935 5728 PMC7542331__F5 Regulatory loops around TGFB1 link important transcription factors and cytokines 2308 7421 1958 1906 6615 117581 7040 2146 864 10365 687 6352 7291 PMC7544055__F5 Toll like Receptor signalling by Prevotella histicola activates alternative NFKB signalling in Cystic Fibrosis bronchial epithelial cells compared to P. aeruginosa 7097 7100 7099 5971 PMC7545690__F1 Flow chart for selecting SNPs in the folic acid metabolic pathway genes 4094 2346 7298 1637 PMC7545926__F8 Schematical representation of the protective mechanism of H2O2 preconditioning for improving the therapeutic potential of BMSCs 7852 2932 2475 595 PMC7552046__F5 Group-B enterovirus proteinase activities impair type 1 signaling pathway activation in infected cells 57506 23118 7189 29110 257397 3661 3665 7098 PMC7554781__F2 Glial cell line-derived neurotrophic factor family ligands (GFLs) signaling 2668 4902 5623 9048 9518 5979 2534 6714 PMC7555335__F3 Constitutive activation of STAT5 7039 1950 2057 1956 2322 3717 5292 2475 PMC7556779__F5 Evasion of the Pattern Recognition Receptor-Type I Interferon (PRR-IFN-I) Pathways by Coronaviruses (CoVs).A simplified schematic of the canonical IFN response after sensing RNA viruses 3454 3455 7297 3716 115004 6772 6773 57506 29110 3661 3665 PMC7559019__F4 Various factors influence the occurrence of liver cancer 619501 4771 5728 3265 5091 PMC7561410__F2 Signaling pathways in the epididymitis induced by UEPC 7100 7099 4615 7124 PMC7563377__F8 Model illustrates targeting of the hedgehog (Hh) signaling using PSMA aptamer conjugated PBM-NPs inhibits prostate cancer tumorigenesis 6469 5727 6608 2735 51684 PMC7563957__F1 Simplified diagram of the 5-fluorouracil (5FU) conversion system 6241 6240 7298 7083 4907 1890 5471 PMC7564661__F4 Membrane damage signaling 114548 10628 10626 3553 PMC7564852__F4 Schematic representing the molecular mechanism of transcriptional repression in TCF/LEF-dependent Wnt outcomes 324 1499 26524 168002 607 PMC7564912__F8 Diagram indicating the mechanism of IITZ-01-induced TRAIL sensitization 867 8772 8239 PMC7565128__F1 Hh pathway (inactive state and active state) and the crosstalk between Hh and EGFR pathways 6469 1956 2735 3725 5727 1950 PMC7565286__F1 Summary diagram of transport, signaling and degradation of vitamin A metabolism and RA synthesis 5950 64220 9249 216 8854 220 PMC7568652__F4 CNTF pathway genes upregulated (red) or downregulated (green) by exposure of primary human keratinocytes to TSST-1 (100 μg/ml) or SEB (100 μg/ml) in triplicate assays for 6 h exposure time 1270 1271 3977 2885 2475 PMC7571393__F2 Summary of the regulatory network and mechanisms of circ_ASPH in CCA cells.Abbreviations: ASPH: aspartate B‐hydroxylase; CCA: cholangiocarcinoma 693166 9619 444 PMC7573473__F4 BCL-2 family members and their role in the apoptotic pathway 581 637 572 PMC7573576__F2 Synthetic lethal pathway: single pathway 8289 57492 6599 6597 86 6602 6598 6601 PMC7576031__F2 Protein tyrosine phosphatase receptor type D (PTPRD)—mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review 1950 5789 6774 1499 3576 960 PMC7577509__F1 Clinical implications of biomarker interactions in CRC 673 2064 5266 PMC7579731__F1 Contemporary treatment approaches for metastatic colorectal cancer driven by BRAF V600 mutations 1956 2885 673 2932 324 2475 1499 PMC7579760__F3 Hepatitis C virus life cycle 3949 1956 975 6010 9076 PMC7582278__F6 Ingenuity Pathway Analysis (IPA) prediction network of miR-342-3p/-5p and cardiovascular disease 7424 5266 653509 8517 5155 PMC7584080__F1 Pathway map highlighting all seven genes modified during this study in red 10296 7054 4118 11113 PMC7589635__F1 Genetic pathomechanisms of FSHD types 1 and 2 23347 1789 100288687 PMC7590211__F2 Role of TRIMs in the control of p53 tumor-suppressor protein 23650 440730 4193 2932 10155 324 1499 7706 373 8805 1000 960 4040 PMC7590459__F1 Simplified diagram of the KP 3620 8942 8564 23475 PMC7597673__F9 Photoreceptor metabolism cycles between an anaerobic light cycle and an aerobic dark cycle associated with phototransduction through PDE6 activities and mediated by SIRT6 and HIFlA 51548 2475 3091 PMC7600430__F7 Schematic diagram illustrating the proposed mechanism of (−)-agelamide D-mediated radiosensitization in HCC 22926 83939 468 PMC7600458__F8 Signaling pathways underlying the cooperative relationship between stearic acid and TNFA for MIP-1A/CCL3 production 3661 7099 7507 4615 3654 51135 8717 7189 PMC7601167__F1 Graphical abstract depicting the mechanisms of inherent and acquired resistance to PI3K inhibition at different vertical nodes along the PI3K/Akt/mTOR pathway 5290 2475 1021 1019 595 PMC7602614__F2 JAK/STAT signaling drives the differentiation of T helper cells (Tregs) 6772 6775 2625 6778 3553 6774 920 50943 PMC7602704__F1 Involvement of TPMT on the thiopurine metabolic pathway 7498 316 7172 3704 79068 3614 8833 PMC7604315__F2 Neddylation and HCC 7428 4738 6295 PMC7640369__F6 Pathways in which radiosensitizing effects of c-myc gene knockdown induced G2/M phase arrest by intrinsic stimuli through the mitochondrial signaling pathway 891 595 637 PMC7643212__F4 Tumor necrosis factor receptor-associated factor 1 pathways involved in T cell survival 7185 2308 3718 PMC7643645__F6 Potential working model for the suppression of Asperolide A in bone metastatic breast cancer 2475 4772 1513 PMC7646582__F1 Diagram illustrating the diagnostic features of cutaneous melanoma and uveal melanoma 3815 2767 2776 57105 5332 1029 1964 23451 6427 8314 PMC7646947__F3 Receptors and substances involved in metabolism that affect muscle protein synthesis and degradation in cancer cachexia 7421 5166 3479 PMC7648632__F2 PD-L1 degradation pathway and immunotherapy for cancer 102 6868 1950 10331 5091 2932 4286 1956 54918 PMC7649293__F5 An Msx2-Sp6-Follistatin Pathway Operates During Late Stages of Tooth Development to Control Amelogenesis 4488 80320 10468 PMC7649569__F3 Major milestones in the development of the Hippo signaling pathway 5784 759 1499 4771 PMC7651862__F8 Our working model in this study 4591 5728 2932 1499 51176 6925 595 960 7291 4316 PMC7654650__F4 Stem cells and lung regeneration 7356 3856 6440 21 27074 84525 10630 177 362 652 PMC7655968__F2 Simplified representation of the structured reaction pathway of glycolysis (Maria, ), and of the TRP synthesis (in the yellow area) (Maria et al., ) in E 5805 11113 4118 PMC7659026__F2 HMGB1 participates in inflammatory processes 6387 3146 7852 PMC7659166__F4 CeRNA network directly associated with hypertensive nephropathy 104472715 286103 55000 84848 5507 5577 10000 PMC7659352__F13 Co-treatment with coffee decoction and tamoxifen markedly induces apoptosis by activating p53 in MCF-7 cells 581 7031 1509 9687 5241 PMC7661869__F1 ARHGAP24 inactivated Rac1/Akt/NFKB in acute pneumonia 5879 83478 3553 PMC7662069__F8 MiR-497-5p regulating osteo/odontogenic differentiation of SCAP 64750 4087 4088 4089 PMC7662392__F2 Potential mechanisms for KSHV manipulating IL-1 signaling pathway 90865 27179 27177 3556 8807 4615 3656 3654 51135 3554 8809 9173 PMC7662673__F8 Suggested mechanism by which nonanal induces the growth factors expression in DPCs via the cAMP signaling pathway 1499 51176 3479 PMC7662679__F1 Monoclonal antibodies: types and mechanisms of action 652070 941 942 PMC7664111__F7 Graphical rendering of GRP78-dependent CRIPTO signaling driving stem-like tumor cell phenotypes 6997 4838 6714 4087 4088 PMC7666630__F4 Constructed ceRNA networks based on the selected vital genes related to the MAPK signaling pathway: (a) the circRNA-miRNA-mRNA network and (b) lncRNA-miRNA-mRNA network 11221 1850 3725 1847 2353 10912 627 3315 4616 1848 3164 1844 284029 PMC7666787__F7 Role of Tim-3 in breast cancer 6774 595 7422 4312 7423 PMC7677403__F1 RIG-I-like receptors (RLRs) mediated signal transduction pathway 1283 57506 3661 3665 PMC7683158__F3 SUMOylation in the nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) pathway 3550 51588 59343 472 PMC7690808__F3 TGFB targeting factors that “lock” NK cell functions 7046 4088 2475 8320 969 10666 PMC7691524__F7 RA Metabolic pathways affected by DEAB and TTNPB treatments 9249 54884 316 8854 157506 5950 1592 56603 5995 PMC7693871__F7 The pathway of Ac2-26 effect: (A) the mechanism of the anti-inflammatory responses of Ac2-26 in HaCaT cells 3717 4312 6774 PMC7695978__F1 miR-363 Alleviates Detrusor Fibrosis via the TGFB1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM 4087 4088 4092 1278 4089 PMC7696523__F1 Canonical Hedgehog signaling in Basal Cell Carcinoma 6608 8643 2736 51684 PMC7698885__F6 PNPLA3 I148M promotes activation of HH signaling and its downstream target Yap 80339 5211 5315 2736 374 2294 PMC7699248__F2 Wnt/Beta-catenin signaling pathway represses VDR expression 1499 7421 442917 PMC7701524__F10 Schematic illustration of the potential molecular mechanism of miR‐148a‐3p as a tumour suppressor in PC 7471 1499 595 PMC7702050__F2 RNAi‐mediated regulation of gene expression 54487 29102 57510 5901 27161 6476 PMC7704563__F8 Schematic overview of the distinct roles of p38A depending on the disease stages during NAFLD progression 5465 2919 596 836 PMC7705175__F1 Autophagy-lysosomal pathway (ALP) 1514 1508 1509 PMC7705238__F2 T-cell immune axis and associated cytokines in the pathogenesis of psoriasis, hidradenitis suppurativa, atopic dermatitis, and alopecia areata 2312 6278 6279 6280 114548 6364 1235 PMC7708728__F1 Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors 7124 1401 8564 PMC7709037__F3 Merging network associated with the EGFR/ERBB2 signaling pathway by IPA-identified three networks (#1, #5, and #12 in ) 1956 10747 54538 2064 55742 PMC7710592__F1 Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in Caenorhabditis elegans 353 132 100 PMC7710791__F2 Pathway 1—management of a previously healthy child/adolescent, suspected, or probable case of COVID-19 6476 7431 5447 2241 176 PMC7712978__F2 P53-AB feedback loop revisited 351 51548 2475 PMC7716495__F1 Activated and inhibited Wnt/Beta-catenin pathway 1499 324 2932 PMC7718954__F1 Necroptosis, apoptosis, and pyroptosis signaling pathways 7124 8737 581 11035 3553 197259 79792 PMC7718954__F4 cGAS‐STING signaling pathway 115004 29110 3661 4975 PMC7721491__F4 Association of PPARs with neuroinflammation 3458 3569 7124 PMC7723170__F1 Wnt/Beta-catenin signaling pathway 2932 324 1499 4040 4041 PMC7728437__F1 On-Off DSGCs in Gabra2 cKO mice show reduced direction selectivity and reduced null-direction inhibition in the noisy background 51322 2555 4397 PMC7731760__F4 Metabolic pathway of D-mannitol in O 130589 2821 5208 5210 PMC7731760__F5 Metabolic pathway of cordycepin in O 132 6240 6241 5813 5814 PMC7734336__F7 Elements of the SPINK1 pathway are involved in PDAC progression 7045 5651 1508 4087 4088 5645 PMC7736362__F1 Rewiring yeast metabolism to synthesize products beyond ethanol 11113 847 5132 PMC7737398__F9 Pathways of ES and SR 5328 840 8139 PMC7738752__F1 Omega 3 and Omega 6 metabolic pathway (from ) 9415 3992 100 PMC7738904__F1 Essentials of TGFB signaling pathway 7939 4087 4089 4088 PMC7744330__F8 Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization 8074 11197 5167 6422 8325 56172 PMC7754020__F8 Metabolic reprogramming of glycolysis and glutamine metabolism are key events in myofibroblast transition in systemic sclerosis pathogenesis 7040 4087 4088 9817 4089 PMC7757024__F2 SIRT1 regulates neuroendocrine secretion 7054 6285 7253 23411 PMC7757049__F4 miR-340 is involved in the regulation of cancer cell apoptosis 6774 9531 9021 1499 PMC7758122__F4 Cross-talks between seven primary regulatory pathways of RDNI for inflammation 6262 3603 5743 PMC7758635__F7 Hedgehog co-receptor BOC differentially regulates SHH signaling during craniofacial development 91653 5727 6608 2735 PMC7760556__F1 Possible pathways for immunogenic activation in response to autologous iPSCs-whole cell vaccines 325 940 958 1674 941 942 PMC7767853__F4 Interactions between picornavirus 2C protein and the NFKB and retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) pathways 64127 57506 3661 PMC7774460__F2 RT induces local immunogenic effects 3458 7124 978 PMC7779046__F2 The ‘Hedgehog Signaling Pathway’ page includes a description of the pathway, links to sub-groups and other related gene groups 6608 5979 27040 4397 100187761 PMC7779201__F3 Hypothesis of Apatinib acquired drug‐ resistance mechanism caused by WRN point mutation 5728 4193 7157 7486 6098 PMC7784988__F6 Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration 3371 1956 1950 PMC7785232__F6 GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection 10461 2621 3458 960 911 920 958 941 942 PMC7788045__F6 Schematic illustrating the Sirt1–FGF21 axis and vilda-mediated cardiac protection 1803 23411 26291 PMC7792759__F3 TGFB signalling pathway in breast cancer cells 4087 4088 4089 3217 PMC7793262__F2 Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation 3586 3458 6772 6774 PMC7793796__F5 CAM-DR in leukemia 1499 2932 960 7412 PMC7796296__F9 Involvement of the ERK/HIF-1A/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells 6375 2829 999 1000 1499 PMC7796313__F1 Therapeutic targeting of TGFB in cancer: hacking a master switch of immune suppression 4087 4088 4089 PMC7796775__F1 Steroidogenesis pathway in 21-hydroxylase deficiency 1583 6770 1585 1589 3284 1584 1586 3291 8644 6822 PMC7797087__F1 Schematic model illustrating the cross-talk between the ET-1R axis and the YAP pathway 6714 7157 7018 PMC7797432__F2 SFRP-2 in the Wnt/Beta-catenin signalling pathway in cancer 6423 2932 324 1499 673 4286 PMC7797765__F1 Simplified overview of the complement pathway 718 727 729 730 PMC7801279__F2 Drugs treat VaD through regulating inflammation-related signaling pathways 7099 4615 114548 23411 3553 PMC7806419__F7 Schematic of the possible signaling pathway of leukocyte immunoglobulin‐like receptor A3 (LILRA3) 3107 3135 11026 5163 PMC7809757__F1 EDA signaling pathway 10913 367 128178 7189 23118 PMC7810549__F9 Xiaoyaosan exerts its antidepressive effects in rats with chronic restraint-induced stress via regulating the activation of the immunoinflammatory response induced by the TLR4/NLRP3 inflammasome signaling pathway in the colon 7099 7189 114548 PMC7813845__F3 Role BRD4 in regulating the NLRP3 pathway in inflammation and pyroptosis 3553 3606 834 29108 114548 23476 5970 PMC7816137__F4 Met1-linked ubiquitin machinery in inflammation and infection 7332 81858 90268 1540 9825 57506 3661 PMC7817101__F8 Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKA stability via selective autophagy 6613 4077 301 PMC7817854__F2 miRNAs targeting SMO oncogenic hedgehog pathway to induce apoptosis in CRC 2121 132884 6469 3549 50846 6608 PMC7820616__F7 Survival of salivary gland cancer stem cells requires mTOR signaling 2475 253260 648 PMC7824062__F1 Competition of 2-OBA and Pyr in the l-threonine-overproducing E 7067 7068 1636 PMC7825454__F7 Proposed signaling pathways regulated by HSV-2 infection and TRIM26 activation 7726 29110 3661 PMC7827005__F2 Cell adhesion-induced activation of signaling pathways 3569 7412 3383 2146 3479 596 PMC7828503__F3 Signaling lymphocytic activation molecule family receptor (SLAMF) 3 signal transduction is mediated via self-ligation and cell–cell interactions 324 717 2534 2885 7018 PMC7843420__F8 STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis 9308 977 952 9242 3976 3977 2885 6774 2625 3569 3570 7291 PMC7843555__F1 Five domains of T-cell dysfunction 7528 355 151888 3902 201633 1493 920 114836 941 940 PMC7843612__F6 TGFB pathway regulation by miR-331 4088 4087 4089 595 894 PMC7847103__F1 Subgroup specific actionable molecular pathway in MB 6469 7048 6608 4089 51684 324 2735 2736 4088 4087 2932 1499 PMC7850464__F1 B7-H1/PD-1 signaling pathway in osteosarcoma 6774 10013 324 5728 PMC7854732__F10 Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer 8405 7113 2078 367 PMC7859453__F1 MOB, RASSF, SAV scaffolding proteins play an essential role in activating the Hippo pathway 374 2069 1950 4771 84962 PMC7859776__F7 An illustrative model to show the proposed mechanism of miR-126-3p promoting sorafenib resistance in HCC 5159 161742 619501 PMC7859922__F1 Chemokines in hepatocellular carcinoma 619501 6387 7852 PMC7862443__F2 Met1-Ub Machinery 90268 81858 10537 1540 9825 6015 PMC7863575__F1 Steroidogenic pathway 1583 6770 6822 1586 3284 8644 6716 1589 1584 PMC7865281__F4 Notch-dependent signaling events and signaling crosstalk during the differentiation of MSCs towards osteocytes 860 23462 9242 PMC7865543__F3 Signaling pathways involved in regulation of and therapeutic avenues for targeting the LOX family 4015 649 6714 4017 4016 PMC7865618__F3 Mechanism leading to CRS and ICANS and potential role of IL-1 blockade 958 3458 7450 PMC7867092__F2 Leptin-promoted lipid metabolic reprogramming in cancer cells 948 6774 1375 PMC7868022__F5 EBV-induced oncogenesis through the TGFB signaling pathway 4087 4088 4089 PMC7870688__F1 Crosstalk of canonical and noncanonical TGFB signaling pathways associated with renal fibrosis and inflammation in diabetic nephropathy 4092 4087 4088 4086 4090 4089 PMC7870817__F5 GSK3Beta-Beta-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a 1848 1499 2932 7528 PMC7871890__F2 IFN signaling through the Jak-STAT pathway 56832 3716 7297 6772 6773 10379 PMC7873896__F4 Therapeutic molecules that target Wnt signaling pathway at the level of the plasma membrane 7471 7474 4040 4041 22943 PMC7874141__F1 Hypothetical model to illustrate activation of the complement system, inflammation and coagulation following SARS-CoV-2 infection 717 718 727 PMC7877795__F4 Origin of tumor- and metastasis-associated macrophages in mouse models of breast cancer 3565 6387 1950 1435 6347 6348 1493 3082 PMC7879300__F1 Toll-Like Receptors Regulate the Development and Progression of Renal Diseases 4615 7097 7096 10333 10454 23118 3656 51135 7189 7099 7187 3665 3661 7100 51284 51311 54106 7098 PMC7880431__F4 Anti-epileptic drug topiramate upregulates TGFB1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity 160851 2155 7046 7040 4087 4088 6662 5283 6469 89910 7077 5727 PMC7884184__F2 The Keap1-Nrf2 signalling pathway in antioxidative stress-related radio- and chemoresistance 9817 7942 7295 7296 PMC7886502__F1 Regulatory effects of the estrogen-BDNF-mTORC1 signaling pathway in depression 627 1392 1325 PMC7892472__F1 Key aspects of BAFF-R, TACI, and BCMA signaling within the context of CVID 7187 7186 5970 5971 596 PMC7893032__F1 Cell death in head and neck cancer pathogenesis and treatment 7124 8717 11035 197259 PMC7900568__F1 cGAS-STING pathway and type-I IFN signaling 3454 3455 7297 3716 6772 115004 29110 3661 PMC7904608__F2 Metabolic regulation of trained immunity in HSCs 8833 5315 19 3101 5214 3156 PMC7904711__F1 Shh pathway 6608 6469 2737 2736 PMC7905169__F3 Regulation of NF-kB activation by ubiquitin ligases and DUBs 7189 1540 257397 23118 PMC7906172__F9 ADSCs promote functional recovery after spinal cord injury by activating the TGFB1/Smad3/PLOD2 signaling pathway 7048 7046 4087 4088 4089 5352 PMC7911265__F4 Portion of the human metabolic chart (online diagram: ), shown at its highest zoom level with all labels drawn, and displaying a reaction tooltip 7959 266710 290 84693 5860 4357 978 1806 151531 1890 8833 100 4860 9615 PMC7911745__F1 NFKB signaling pathway and the genes associated with BD-like phenotypes 7124 7132 8717 7186 8737 4615 7189 5971 4790 PMC7913176__F4 Degree Adjusted Large-Scale Network Analysis Reveals Novel Putative Metabolic Disease Genes 10296 5894 7534 7052 10048 367 51514 4988 10987 351 387103 558 7046 2908 7153 2671 2171 1956 PMC7913870__F1 Hippo pathway 6789 6788 9113 26524 PMC7913870__F3 Therapeutic targets to reactivate the Hippo pathway 2146 238 6789 6788 9113 26524 9641 8178 10129 PMC7919195__F6 Signaling pathway network of potential AA targets 766 377677 23632 3320 5724 3815 3326 151 2859 2247 150 765 762 3358 3265 3356 7422 3357 5664 152 3362 1814 2246 1565 148 1813 55851 23385 PMC7920452__F3 Representation of the dermatological signaling pathway 64084 51806 9436 7301 55065 3858 4070 6366 55620 6372 23430 1999 2012 282618 5999 4162 6462 PMC7920467__F1 Ceramide de novo synthesis pathway 10715 204219 79603 91012 PMC7926563__F2 Therapeutic agents targeting the B-cell receptor (BCR) signaling pathway in follicular lymphoma 613 6850 4067 PMC7931557__F8 Proposed model of the mechanism underlying the expression and function of LINC00958 in TSCC cell proliferation 27161 100506305 64105 898 595 PMC7935792__F2 Antigen presentation process 920 940 941 942 958 PMC7937683__F8 Loss of desmoglein-2 promotes gallbladder carcinoma progression and resistance to EGFR-targeted therapy through Src kinase activation 1950 1829 1956 PMC7937835__F3 Lessons from mitochondrial proteostasis in adipose tissue 22809 468 9518 6778 PMC7944059__F7 Kyoto Encyclopedia of Genes and Genomes pathway map illustrating differentially expressed genes (DEGs), as identified by protein-protein interaction network analysis using STRING 54997 50863 8205 3815 7216 2690 PMC7944918__F8 Gene ontology enrichment analysis of co-upregulated DEGs in both systemic sclerosis and lung cancer 7097 5879 3569 54472 10333 8772 114609 4703 3929 929 23118 100187907 7099 7189 958 923 1513 54106 7187 PMC7946848__F3 Possible roles of circRNAs in SLE 6041 83939 1786 PMC7953519__F7 Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome 4214 6662 1499 PMC7956931__F2 Simplified overview of EGFR pathway, with numbers of studies included per EGFR pathway inhibitor target 1956 5728 673 2475 PMC7956987__F1 IL-18 signaling pathway 10068 4615 7189 PMC7957534__F2 CTHRC1 modulating collagen deposition and vascular repair following injury through the TGFB signaling pathway 4087 4088 4092 64750 4089 115908 PMC7957700__F1 Normal CD8+ T Cell Response 3932 7535 951 942 941 940 PMC7957753__F9 Signal transduction and regulation of secondary metabolism in response to salt stress in S 4609 4602 7018 PMC7959294__F10 Schematic diagram illustrating the potential targets of HSR2104 to inhibit inflammatory responses and cell migration in BV2 cells 338386 4615 7099 PMC7961018__F1 Canonical TGFB signaling regulates the relationship between prenatal maternal depression and amygdala development in early life 7049 4092 4087 4089 4088 PMC7966414__F1 Simplified metabolism of Lupinus albus nodules and cluster roots under P and N deficiencies 5183 1431 4397 PMC7969667__F10 Schematic model of RipA depicting possible interaction of RipA with surface immune receptor TLR4 and emanating downstream cascades 7099 7054 114609 7189 4193 6389 7124 PMC7970325__F14 Statistically significantly enriched gene ontology (GO) molecular processes (GO-terms) identified for 871 differential genes between radioiodine resistant cancers and other thyroid cancer samples 90993 285533 7494 3300 57088 3305 57211 10808 6734 7873 2249 1646 3303 6048 55586 116138 1645 162494 3776 10106 7184 7881 23753 10525 83592 811 10954 4312 PMC7972934__F7 Mechanistic illumination of the inhibitory role of VB in GBMVB promotes the expression of miR-7-5p in GBM cells and facilitates the delivery of miR-7-5p by exosomes to recipient GBM cells 1956 5111 581 4318 1000 PMC7983022__F1 Hepcidin and iron homeostasis 148738 57817 5045 151176 2475 PMC7985100__F3 Signaling pathways and gene regulation on NLRP3 inflammasome 8737 11035 197259 1499 114548 23405 10628 PMC7988715__F2 EZH2 overexpression in prostate cancer 367 2078 7113 2146 4609 407017 PMC7990797__F6 KEGG enrichment pathways of DEGs related to IL-17 signal pathway and cytokine–cytokine receptor interaction 3606 51561 1236 3552 23765 1432 1440 6364 9618 PMC7991060__F1 Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action 6916 8644 5742 5743 873 10728 5740 80142 9536 56413 PMC7991087__F5 Summarizing Figure 7099 6721 3156 PMC7991738__F1 Apoptosis regulation via Cl− channels in ESCC cell 1192 338440 153241 1181 7097 11064 6683 1080 56262 PMC7993665__F7 Signaling pathway diagram 79792 10628 8011 114548 3553 PMC7997989__F9 TDP-43 and PINK1 mediate CHCHD10S59L mutation–induced defects in Drosophila and in vitro 400916 65018 203228 PMC7998272__F3 Alternate splicing of the LOXL2 mRNA 6714 3091 4017 PMC7998465__F7 Molecular regulatory mechanism underlying UA’s anticancer activity in NSCLC cells, and UA’s inhibition of the EGFR/JAK2/STAT3 signaling pathway and PD-L1 1950 1956 3717 6774 PMC7999836__F1 Metabolic pathway of PC and TG synthesis 4018 7038 5091 355 PMC8000993__F7 Simplified schematic of crosstalk between JA and ABA signaling pathways 51225 54861 23379 PMC8002083__F8 Illustrated model for our proposed molecular mechanism of how moscatilin inhibits HCC cell metastasis through inhibiting uPA expression via down-regulating Akt/NFKB signaling pathway 3052 5340 619501 PMC8002742__F2 Activation of type I interferon production via endosomal Toll-like receptors and RNA sensor signaling pathway in Sjögren’s syndrome 7098 51284 54106 57506 3654 4615 7187 81622 7189 29110 3665 3661 PMC8003055__F6 Proposed mitochondrial pathway for apoptosis in HCC cells induced by compound 1 595 1019 572 PMC8003559__F3 Activation of innate immune signaling pathway by lipopolysaccharide (LPS) and tumor necrosis factor (TNF) 7099 8717 4615 7186 51135 3654 90268 7189 PMC8004487__F3 Role of sphingolipid associated loci in major sphingolipid metabolic pathways 55304 81537 79603 253782 388323 PMC8005619__F1 Intracellular sensing of herpesvirus DNA by DNA sensors and activation of signaling pathway 9447 115004 3428 3553 3606 3661 3665 54106 4615 PMC8005619__F2 DNA Sensing pathways by herpesvirus 115004 9447 3603 3606 3661 PMC8011850__F8 Model depicting the pathway stimulated by TNFA to increase venous endothelial permeability 7124 6714 24145 59341 PMC8012816__F7 Model depicting that PER3 regulates stemness of PCSCs via WNT/Beta-catenin pathway 8863 406 1499 PMC8015171__F9 Basal cell-fibroblast interaction in IPF 4018 1906 7040 5155 59 1277 PMC8021797__F2 Schematic presentation of the STAT1 signaling pathway 3460 3459 3455 7297 3717 3454 6772 6774 6773 PMC8027073__F8 TREM2 and CSF1R interaction in microglial survival 1435 54209 1436 PMC8027873__F2 STRING diagram representing protein interaction pathway derived from the 77 proteins quantified in at least 80% of OCT and in none FFPE samples 2274 8428 4204 26136 1737 10269 1738 4716 27020 11112 10979 PMC8032689__F10 The MAF-TGFB1-crystallin axis that underlies the pathological growth of lens in high myopia 4094 4087 4088 4089 PMC8033373__F4 Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study 260402 7054 5360 PMC8035014__F8 Immune regulatory activity of TCM formula ZQT in TME 3458 6774 2762 PMC8035314__F2 Functional outcomes of the IR/IGF-1R/IRS pathway in normal and breast cancer settings 3481 3479 3480 6462 PMC8036852__F3 Brucella can inhibit the secretion of IL-2 by antigen presenting cells, and then prevent natural killer cells (NK) from secreting inflammatory factors such as IFNG and TNFA 324 942 941 7097 PMC8037152__F1 Leukemic microenvironment supports survival of acute lymphoblastic leukemia (ALL) cells and their immune evasion through multiple interactions 961 4345 6387 7852 9242 PMC8038768__F8 Overview of this study 3082 2885 6494 PMC8047311__F2 Pathogenesis of AAV and the inhibition of the binding of biological agents 718 941 942 940 8760 727 4353 7124 PMC8049958__F12 Hypothesis that autoimmune signaling pathways mediate the pronociceptive effects CRPS patient IgM in muMT fracture mice lacking immunoglobulin 718 721 7124 PMC8051110__F10 Combination of RRM2 silencing and radiotherapy promotes the activation of cGAS/STING signaling pathway in LUAD cells 115004 3661 6352 6241 3627 PMC8052633__F3 Interplay between p62-mediated autophagy and the cGAS-STING-mediated DNA sensing pathway 115004 472 8408 29110 2475 3661 PMC8055972__F8 Regulation of VM formation and NPC metastasis by the miR-124/Foxq1 axis 1003 4318 94234 4313 1956 PMC8059031__F3 ncRNA regulatory network map of acute myocardial infarction 55000 100126297 400550 664613 574461 282 693122 PMC8063392__F5 LCK pathway regulates cisplatin resistance in endometrioid tumors. Downstream of CD55, LCK stimulates expression of DNA repair genes, leading to cisplatin resistance 1604 3932 4920 PMC8063837__F2 Models of signaling in Hedgehog pathway activation in cancer 6608 3552 3553 PMC8080836__F3 GD T cells 920 151888 6774 1493 9580 7535 3458 3553 3606 940 939 PMC8082653__F3 N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies 56339 90427 51441 10644 7095 331 7186 PMC8083806__F2 An update on genetic basis of generalized pustular psoriasis (Review) 4353 1511 26525 79092 4615 130340 2920 2919 79689 7124 PMC8087798__F8 Mechanism of POU2F2 regulates glycolytic reprogramming and GBM progression 5170 5452 2475 3099 PMC8088756__F2 Demyelination as a result of an immune response in patients with COVID-19 929 4615 3661 PMC8088956__F2 Dysregulation of Wnt/B‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application 3082 1499 10298 4751 51701 8312 324 1950 1956 2932 4040 4041 PMC8092109__F9 Cinnamaldehyde inhibits the growth of Phytophthora capsici through disturbing metabolic homoeostasis 790 3712 4163 PMC8102819__F2 Immunopathology of Acute Kidney Injury in Severe Malaria 7124 3596 7412 3383 PMC8106830__F1 Cascade of innate immune response against intestinal fungi 3577 6850 64170 PMC8111291__F8 FOXC1 Negatively Regulates DKK1 Expression to Promote Gastric Cancer Cell Proliferation Through Activation of Wnt Signaling Pathway 1499 4040 4041 324 PMC8115150__F8 Schematic model describing the protective effect of Mzb1 in AMI. Injury of cardiomyocytes led to apoptosis and mitochondrial dysfunction, ROS release, and increased inflammation 51237 581 7124 PMC8120202__F2 Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS 3550 1786 50943 4040 4041 4089 4087 4088 1499 50507 PMC8122117__F4 Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets 9290 79143 2475 PMC8122377__F3 Hepcidin Signaling in Health and Disease: Ironing Out the Details 4615 4089 4090 4086 6774 PMC8124393__F2 Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises 100287314 4040 4041 2932 1499 378938 8420 652995 2475 5728 100187761 PMC8126980__F4 Ferroptosis in infection, inflammation, and immunity 7099 4615 1147 3551 8517 4792 148022 7189 6347 7124 7040 7187 9641 3654 29110 3661 3146 3663 3665 177 1729 3725 6774 115004 340061 1508 PMC8131524__F1 Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Bacteroides fragilis’ Polysaccharide A 100187907 7099 4615 2932 3661 324 942 920 940 29851 PMC8137566__F7 Activation of Wnt/Beta-catenin signaling pathway induced by cooperative activity of ALK and N-Myc 5764 1499 1654 1454 51176 238 PMC8139665__F9 TLR3 Activation by Zika Virus Stimulates Inflammatory Cytokine Production Which Dampens the Antiviral Response Induced by RIG-I-Like Receptors 3661 7098 6772 6774 9021 PMC8141177__F1 LINC00261: a burgeoning long noncoding RNA related to cancer 140828 1499 324 PMC8143883__F6 MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2 442909 302 2475 PMC8144171__F4 Functions and Targets of miR-335 in Cancer 2737 6469 5727 6608 2735 2736 442904 2475 7249 6009 7248 9113 26524 PMC8151260__F1 Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies 1785 3716 3718 1154 5292 596 4609 5008 5771 PMC8151764__F1 Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases 3652 5066 95 PMC8154043__F1 Metabolic origins of non-photorespiratory CO2 release during photosynthesis: a metabolic flux analysis 5183 11113 4118 PMC8155723__F3 Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis 10148 3595 3716 3717 6772 6775 PMC8158769__F1 Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease 717 720 718 PMC8160963__F3 Identifying Novel Actionable Targets in Colon Cancer 7046 4092 4087 4088 4089 PMC8161352__F5 Endophytes: the novel sources for plant terpenoid biosynthesis 3652 2147 5925 PMC8161467__F7 Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling 4194 4193 1869 355 3845 PMC8163803__F6 Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes 55777 2290 494143 PMC8164969__F1 Iron regulatory cycle 3077 7036 148738 57817 151176 164656 PMC8166497__F4 N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis 695 49 351 PMC8166856__F7 STAT3 in gefitinib resistance 6774 1956 6714 3717 PMC8167679__F1 Iron homeostasis and iron-mediated ROS in cancer 983 6774 23657 PMC8168427__F7 Proposed mechanisms of ALDH2*2 to induce atrial fibrillation 217 216 8854 PMC8168453__F2 Schematics of the TIM3/Gal9 signaling pathway in T cells 27040 920 325 7535 3458 3932 2534 1445 PMC8174805__F1 Disparate roles of retinoid acid signaling molecules in kidney disease 9227 64220 2171 PMC8181424__F1 Exercise Factors Released by the Liver, Muscle, and Bones Have Promising Therapeutic Potential for Stroke 57512 3066 8841 627 23411 PMC8186445__F2 Astrocytes in the Neurorepair Process 2932 324 1499 5309 4760 PMC8188762__F2 SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves’ disease 7038 7173 7253 PMC8189177__F1 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes 2255 4617 9242 652 5156 2263 7038 4023 PMC8189177__F2 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes 2255 3976 6440 PMC8193257__F1 Progress of Breast Cancer basic research in China 8205 1234 6362 10384 6352 54093 7103 3553 1956 9958 79923 10544 5806 PMC8193257__F2 Progress of Breast Cancer basic research in China 2295 652 7004 284276 100506930 6347 5452 10135 2475 PMC8194090__F3 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation 860 6662 3549 6608 PMC8197962__F1 ZNF-281 as the Potential Diagnostic Marker of Oral Squamous Cell Carcinoma 1499 23528 407040 8549 4318 6659 PMC8198407__F3 Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies 4524 4552 4522 1719 PMC8199999__F1 Minor Intron Splicing from Basic Science to Disease 6794 6399 55599 8233 26870 267010 100151683 PMC8208723__F10 Root meristem size reduction and stem cell death in response to DSBs 472 5300 5303 PMC8210588__F5 Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives 4598 4597 3652 340451 PMC8210623__F4 Analyzing signaling activity and function in hematopoietic cells 7124 7099 4615 3661 PMC8215365__F12 Ligilactobacillus salivarius Strains Isolated From the Porcine Gut Modulate Innate Immune Responses in Epithelial Cells and Improve Protection Against Intestinal Viral-Bacterial Superinfection 3725 7098 100187761 4118 7808 4117 203447 7099 929 2353 367 PMC8215834__F7 Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway 7124 2335 3569 6714 6774 PMC8217759__F7 M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13RA2/MAPK Pathway in Rat Intervertebral Disc Degeneration 3598 1116 4314 4318 PMC8220159__F2 Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Toxoplasma gondii Infection and Potential Therapeutic Implications 8408 958 596 PMC8220689__F5 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers 693167 100187761 1499 56998 PMC8228919__F1 Toll-Like Receptor Signaling in the Establishment and Function of the Immune System 4615 81622 29110 3661 7187 3665 7098 51311 54106 51284 51135 3654 3656 7189 7096 7097 10333 7099 PMC8233740__F1 Using Diatom and Apicomplexan Models to Study the Heme Pathway of Chromera velia 210 100187761 7390 1690 7389 1371 5498 2235 727 PMC8234974__F3 Engineered EV-Mimetic Nanoparticles as Therapeutic Delivery Vehicles for High-Grade Serous Ovarian Cancer 1950 961 140885 2522 PMC8238877__F1 SARS-CoV-2 signals through TLR2 to activate proinflammatory cytokine expression 7097 4615 7124 3627 PMC8245224__F9 Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells 3099 7428 3934 PMC8245375__F5 Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity 7099 7189 7098 51284 3665 3454 3455 3661 6772 10379 6041 4599 4600 9636 PMC8246550__F3 Epigenetic regulation of cancer stem cell formation and maintenance 6996 1786 200424 80312 54790 2146 2160 10873 7018 29102 PMC8250138__F1 Tetraspanins: Novel Molecular Regulators of Gastric Cancer 977 5820 1950 7103 1956 7106 PMC8258330__F2 Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020 9033 5330 29850 24145 8482 255022 119395 10371 133060 PMC8262610__F2 Fc Gamma Receptors as Regulators of Bone Destruction in Inflammatory Arthritis 7189 4772 6850 695 7006 100124696 126014 PMC8262654__F1 Banxia xiexin decoction affects drug sensitivity in gastric cancer cells by regulating MGMT expression via IL-6/JAK/STAT3-mediated PD-L1 activity 3716 1956 6774 29126 5133 4255 PMC8263655__F3 Long noncoding RNAs on tumor immune escape by regulating immune cells differentiation and function 6347 729230 8205 7424 PMC8263657__F4 Basic approaches, challenges and opportunities for the discovery of small molecule anti-tumor drugs 666 581 572 4170 7124 7132 8795 8797 8772 355 331 PMC8264427__F3 Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes 3383 729230 3579 2475 6347 3576 3598 1116 PMC8267409__F1 Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects 100506465 4102 728655 23326 4363 23411 9817 283120 5663 100033819 378938 54064 8503 106144539 252839 283131 23642 6520 8420 5728 51527 PMC8267694__F1 Enigmatic Role of TP53 in Germ Cell Tumours: Are We Missing Something? 4193 596 581 637 572 355 PMC8269276__F1 Promising Treatment Options for Axial Spondyloarthritis: An Overview of Experimental Pharmacological Agents 3716 3718 3717 3458 7173 2056 PMC8269395__F5 Emerin Represses STAT3 Signaling through Nuclear Membrane-Based Spatial Control 3569 6774 5081 4656 PMC8273387__F4 Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes 8737 11035 841 197259 596 PMC8273837__F4 Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis 4040 4041 59343 1499 595 8061 894 4920 387 PMC8276817__F2 Molecular targets for FAK inhibitor combination therapy 1499 387 9113 PMC8278124__F8 Astragalus polysaccharide attenuates LPS‐related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway 7099 7186 7189 4772 1513 3569 PMC8279535__F3 Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena 920 7124 50943 7480 PMC8283906__F3 Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target 55246 54106 4353 PMC8285369__F1 Melatonin interferes with COVID-19 at several distinct ROS-related steps 3569 7124 4353 PMC8287254__F1 Lactate as Potential Mediators for Exercise-Induced Positive Effects on Neuroplasticity and Cerebrovascular Plasticity 27198 7422 252995 627 PMC8287779__F2 Exosomes in lung cancer metastasis and clinical applications: an updated review 11278 22880 4318 6774 3717 PMC8289367__F2 Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer 56339 114609 958 920 941 54915 942 79068 3939 1236 PMC8290460__F1 MicroRNA-129 in cancer and non-cancerous diseases (Review) 2475 9689 9355 10951 7529 PMC8291015__F1 Impact of the COVID-19 pandemic on inflammatory bowel disease patients: A review of the current evidence 7113 59272 6868 PMC8294384__F6 Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens) 1544 1571 1576 PMC8307807__F1 Wnt Signaling by FOX Transcription Factors in Cancer 4040 4041 1499 PMC8307807__F3 Wnt Signaling by FOX Transcription Factors in Cancer 2305 1499 2309 27086 442425 PMC8313238__F5 CD38 in the age of COVID-19: a medical perspective 952 7113 51284 4615 3553 114548 7124 6347 7226 PMC8314387__F2 Signaling Pathways Involved in Diabetic Renal Fibrosis 4092 4087 4088 4089 PMC8315016__F8 Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer 3553 55384 114548 79792 PMC8318568__F2 An Ecological Basis for Dual Genetic Code Expansion in Marine Deltaproteobacteria 1652 2638 4553 PMC8327170__F3 Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma 7187 3479 3480 PMC8328385__F1 Alopecia Areata: An Autoimmune Disease of Multiple Players 8178 5132 2833 4283 3627 6373 PMC8332859__F8 CR13626: a novel oral brain penetrant tyrosine kinase inhibitor that reduces tumor growth and prolongs survival in a mouse model of glioblastoma 5979 2534 9365 PMC8339349__F7 lncRNA H19 facilitates the proliferation and differentiation of human dental pulp stem cells via EZH2-dependent LATS1 methylation 9113 283120 2146 PMC8339999__F9 Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NFKB Axis 4615 114548 7054 PMC8340210__F2 Development of PARP inhibitor combinations for castration resistant prostate cancer unselected for homologous recombination repair mutations 3169 10038 367 PMC8343457__F1 Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease 435 5009 8942 PMC8345475__F2 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics 100188776 3664 3662 27086 PMC8347175__F2 Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx 3995 8560 123099 PMC8348955__F11 Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury 5465 26291 1581 2260 152831 2264 6720 2475 9965 PMC8349099__F1 Calcium signaling in hepatitis B virus infection and its potential as a therapeutic target 90550 7419 596 6786 84876 836 6714 948 PMC8349405__F5 Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens 4615 57506 29110 3661 3663 7297 3716 6772 10379 PMC8349779__F5 Altered metabolic events in renal cell carcinoma (RCC) 7428 2638 4018 PMC8350724__F1 Pyroptosis, a New Breakthrough in Cancer Treatment 114548 9447 22861 3553 3606 58484 79792 PMC8350724__F2 Pyroptosis, a New Breakthrough in Cancer Treatment 114548 79792 3553 PMC8351877__F4 Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy 246778 4783 6774 920 942 325 958 91653 3458 2625 6775 864 2833 9021 PMC8358664__F2 P53 Family: A Role in Lipid and Iron Metabolism 47 2194 23417 355 PMC8359396__F1 Pharmacological validation of TDO as a target for Parkinson’s disease 130013 23475 23498 8564 8942 PMC8364703__F5 Bacterioferritin: a key iron storage modulator that affects strain growth and butenyl-spinosyn biosynthesis in Saccharopolyspora pogona 22934 8772 51 6390 PMC8365418__F10 Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage 1749 4760 429 63974 4804 5979 PMC8376648__F8 Proposed working model 9112 10644 79068 11171 PMC8377014__F1 Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global Proteome Analysis 2638 6418 4397 PMC8377849__F10 Pitx controls amphioxus asymmetric morphogenesis by promoting left-side development and repressing right-side formation 4838 8022 5626 PMC8387910__F1 Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review 51094 79602 5465 PMC8393382__F4 Well-Known and Novel Players in Endothelial Dysfunction: Updates on a Notch(ed) Landscape 3383 7038 27329 1499 PMC8396295__F7 Gene-Metabolite Network Analysis Revealed Tissue-Specific Accumulation of Therapeutic Metabolites in Mallotus japonicus 790 1312 4397 PMC8397734__F4 Sulfur energy metabolism and physiological interaction scheme of E. rectale and B. wadsworthia in the human gut 1725 6503 4583 PMC8402498__F9 Escherichia coli Alpha-Hemolysin HlyA Induces Host Cell Polarity Changes, Epithelial Barrier Dysfunction and Cell Detachment in Human Colon Carcinoma Caco-2 Cell Model via PTEN-Dependent Dysregulation of Cell Junctions 100187761 100188835 759 8213 5228 4609 PMC8408949__F1 Biology of bone morphogenetic protein signaling pathway in cerebrovascular system 4090 4086 7018 4089 PMC8416371__F10 Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis 9118 339855 6955 10129 PMC8419056__F3 Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment 7124 7099 3146 920 114548 140609 1956 55876 637 PMC8421037__F2 YAP/TAZ activity is central to coordinating cell migration 9828 9411 93663 387 7003 8463 7004 7005 7057 PMC8427189__F2 Recent Progress in the Understanding of the Effect of Sympathetic Nerves on Hair Follicle Growth 7124 1392 5443 PMC8430839__F2 Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus 10379 7297 3455 3716 6773 PMC8432624__F2 Protein Arginine Methyltransferase 5 Functions via Interacting Proteins 55352 92140 1499 7832 619501 PMC8435905__F3 Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features 1581 27040 10858 1576 1593 9420 80270 120227 PMC8440041__F2 Mucus targeting as a plausible approach to improve lung function in COVID-19 patients 196 3579 1956 4082 4583 5991 PMC8441939__F1 Immune response to SARS‐CoV‐2 in children: A review of the current knowledge 3661 6773 10379 PMC8442909__F4 Characterization of the Potential Role of NTPCR in Epithelial Ovarian Cancer by Integrating Transcriptomic and Metabolomic Analysis 7124 4939 2633 3665 4600 PMC8445921__F5 Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis 367 435 7054 PMC8448164__F7 Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action 2475 7249 7248 PMC8448728__F5 PIGG defines the Emm blood group system 5277 5279 5283 51227 9091 84992 8818 9487 284098 95 55650 23556 93183 54965 2821 9488 5281 84720 54872 10026 80055 8733 94005 128869 51604 PMC8450343__F6 Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects 3567 3558 3458 1437 3459 3592 3595 1435 3460 3593 6772 3569 246778 939 7124 30009 3574 3689 596 29126 84868 3606 355 958 PMC8458263__F2 RSR blockade stimulates innate anti-tumor immunity through the cGAS-STING pathway 3458 3002 6352 3627 29110 3661 PMC8458763__F5 Mechanobiology of Endothelial-to-Mesenchymal Transition in Cardiovascular Disease 9780 4087 302 PMC8459566__F1 Hypofibrinolysis in type 2 diabetes and its clinical implications: from mechanisms to pharmacological modulation 1401 7018 3667 718 4353 5350 7450 5340 PMC8463593__F10 BAFF is involved in B cell differentiation and activation through the NFKB signaling pathway in RA 930 939 1401 PMC8465370__F5 Insights into Alexandrium minutum Nutrient Acquisition, Metabolism and Saxitoxin Biosynthesis through Comprehensive Transcriptome Survey 275 435 11113 1356 5009 PMC8467271__F3 Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery 7345 10716 9958 9618 7375 4088 8239 4089 220213 64750 4092 PMC8467361__F2 Diabetes Mellitus and Periodontitis Share Intracellular Disorders as the Main Meeting Point 23411 8408 2475 PMC8468667__F7 MicroRNA-Based Risk Score for Predicting Tumor Progression Following Radioactive Iodine Ablation in Well-Differentiated Thyroid Cancer Patients: A Propensity-Score Matched Analysis 1871 5728 27161 23405 7157 4609 207 5295 596 23411 7124 598 PMC8469949__F1 Actin Cytoskeleton Dynamics and Type I IFN-Mediated Immune Response: A Dangerous Liaison in Cancer? 4615 57506 29110 3661 3665 3454 3455 6772 3716 6773 PMC8473795__F3 Glycocalyx Impairment in Vascular Disease: Focus on Inflammation 114548 4615 3553 3383 7412 PMC8474727__F6 ALDOA inhibits cell cycle arrest induced by DNA damage via the ATM-PLK1 pathway in pancreatic cancer cells 226 5347 472 PMC8475157__F1 Abnormalities in the signaling pathway that exacerbate type I IFN responses 2113 7297 6772 6775 6773 3663 3665 3716 10379 3659 3394 PMC8476258__F2 Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China 3952 6774 5563 5562 53632 4852 PMC8478603__F1 Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells 958 940 941 920 PMC8478647__F2 External and internal signaling events on the surface of lysosomes 4864 652968 7942 153129 64798 6009 80317 9066 PMC8483493__F8 Proposed the mechanism within the hypothalamic nuclei proopiomelanocortin (POMC) neurons that leptin signaling may contribute to the high sympathetic nerve activity (SNA) and increased blood pressure observed in the HFD obese rats 6774 5443 23411 PMC8484528__F5 Integrated Analysis and Finding Reveal Anti–Liver Cancer Targets and Mechanisms of Pachyman (Poria cocos Polysaccharides) 6774 4318 213 598 836 7422 7852 2247 5788 7124 3265 1950 6714 PMC8485521__F2 MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells 79804 5728 100302203 2475 PMC8485759__F4 Purine synthesis and its dependency on mitochondrial metabolism 8833 471 158 10606 2618 5471 4522 PMC8487719__F1 Hedgehog signaling pathway 5727 51684 2735 2737 2736 6608 9149 PMC8487963__F1 MDS and current therapeutic options 2056 2057 3717 4087 4088 995 10320 PMC8490548__F2 MTHFR (methylenetetrahydrofolate reductase: EC 1.5.1.20) SNPs (single-nucleotide polymorphisms) and homocysteine in patients referred for investigation of fertility 875 4524 1719 PMC8490739__F7 SMYD3/ITGB6/TGFB1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids 64754 3694 7040 999 1000 PMC8494307__F7 NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis 114548 3553 3554 PMC8494520__F2 Immunology and Immune Checkpoint Inhibition in Ovarian Cancer – Current Aspects 3627 6352 115004 PMC8497507__F7 Schematic showing the roles of mGluR2/3, mGluR1 and DGK in controlling responses evoked by MF activation 2911 1608 1607 5332 7222 2912 3763 PMC8503266__F3 Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects 1950 5971 4050 PMC8505728__F7 Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans 367 4282 7064 1674 10763 PMC8505796__F2 Aldehyde dehydrogenase 1A1 and 1A3 isoforms – mechanism of activation and regulation in cancer 57291 4089 1499 216 PMC8505811__F1 Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease 2475 4087 4089 7189 4772 4088 PMC8511458__F2 Interplay Between Non-Canonical NFKB Signaling and Hepatitis B Virus Infection 4055 7187 9582 200315 5971 958 PMC8514722__F7 NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation 4783 100187907 2475 3553 PMC8515174__F2 Complement inhibition for the treatment of COVID-19 triggered thrombotic microangiopathy with cardiac failure: a case report 8190 11093 828 PMC8516647__F4 Functions of the XAF-1 protein in promoting p53 mediated apoptosis 54739 6478 28996 4193 PMC8516864__F4 Tryptophan/kynurenine pathway 8564 7054 8942 130013 23475 PMC8523334__F3 TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy 7185 7187 7186 PMC8524328__F4 Exploration of the existing and candidate crosstalk between the diagrams of the COVID‐19 Disease Map 9118 5970 3630 57506 2353 387 83737 3725 4609 1311 29108 PMC8529123__F3 MCM3AP-AS1: An Indispensable Cancer-Related LncRNA 114044 57181 5728 221937 6678 1977 PMC8530315__F7 VitD3 effects in D3-MDMs during DENV-2 infection 1594 7421 54106 51284 7098 6772 6773 4938 10379 PMC8530550__F1 Artificial immune synapse with an introduced DNA-based mechanics-controlling module 3932 7535 324 4827 PMC8533862__F8 Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses 3661 57506 29110 3663 4615 51135 3665 7297 6772 10379 3716 3660 3659 PMC8534193__F1 Emerging Influences of Alpha-Fetoprotein in the Tumorigenesis and Progression of Hepatocellular Carcinoma 174 26137 22882 PMC8536552__F7 Heat stress inhibits TLR4-NFKB and TLR4-TBK1 signaling pathways in broilers infected with Salmonella Typhimurium 7099 29110 114548 3661 3553 PMC8540355__F1 Pathogenesis, Molecular Mechanisms, and Therapeutic Potential of the Interferon Pathway in Systemic Lupus Erythematosus and Other Autoimmune Diseases 7098 54106 4615 51311 51284 3654 3665 3663 29110 7189 7187 3661 57506 115004 7099 PMC8541937__F6 Network pharmacology of triptolide in cancer cells: implications for transcription factor binding 759 2078 367 PMC8543024__F3 Adenomyosis pathogenesis: insights from next-generation sequencing 3845 5163 2885 PMC8546337__F1 Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application 2932 3627 115004 29110 PMC8546664__AF1 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy 3661 29110 338376 472 3458 PMC8546664__F2 Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy 115004 3661 472 545 3458 PMC8551388__F1 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica 847 351 9817 3553 PMC8551388__F3 Hypoxia-Induced Neuroinflammation in Alzheimer’s Disease: Potential Neuroprotective Effects of Centella asiatica 847 351 9817 3553 PMC8554324__F1 Leukemic Stem Cells: From Leukemic Niche Biology to Treatment Opportunities 6387 960 948 9242 PMC8557262__F1 Possible harm from glucocorticoid drugs misuse in the early phase of SARS-CoV-2 infection: a narrative review of the evidence 51284 59272 2638 PMC8560265__F5 Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway 7099 596 581 7124 PMC8560782__F1 Urinary excretion of epigenetically modified DNA as a marker of pediatric ALL status and chemotherapy response 6996 7374 23583 8930 PMC8561165__F3 Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease 8564 3606 4283 PMC8561620__F5 Regulatory effect between HMGA2 and the Wnt/Beta-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma 4040 4041 1499 1019 595 8091 PMC8564058__F9 An ATX-LPA6-GA13-ROCK axis shapes and maintains caudal vein plexus in zebrafish 4018 387 1499 PMC8564353__F1 Exosome CTLA-4 Regulates PTEN/CD44 Signal Pathway in Spleen Deficiency Internal Environment to Promote Invasion and Metastasis of Hepatocellular Carcinoma 4280 5728 960 PMC8566155__F1 Clinical Features and Pathophysiological Mechanisms of COVID-19-associated Gastrointestinal Manifestations 7113 1636 6370 2475 3605 PMC8584118__F2a Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections 4615 7189 3654 91662 7187 5971 PMC8584463__F7 Substrate Stiffness Drives Epithelial to Mesenchymal Transition and Proliferation through the NEAT1-Wnt/Beta-Catenin Pathway in Liver Cancer 8313 1499 7018 324 860 7422 960 PMC8584933__F1 Genome-Wide Analysis of Alternative Splicing and Non-Coding RNAs Reveal Complicated Transcriptional Regulation in Cannabis sativa L. 4015 3652 340451 PMC8589438__F1 Anti-cancer drugs often work by the induction of apoptosis 572 90427 581 PMC8591232__F2 Targeting Macrophage Dysregulation for Viral Infections: Novel Targets for Immunomodulators 2919 6774 3579 3458 PMC8591899__F5 SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities 9817 4094 4703 PMC8595028__F1 Rh-CXCL-12 Attenuates Neuronal Pyroptosis after Subarachnoid Hemorrhage in Rats via Regulating the CXCR4/NLRP1 Pathway 6387 7852 22861 PMC8598918__F1 Receptor tyrosine kinases as druggable targets in glioblastoma: Do signaling pathways matter? 4763 1956 50853 7429 2064 5728 PMC8599200__F6 Normal and Premature Adrenarche 5447 1646 1645 8644 1109 PMC8607246__F2 A novel potentially transforming somatic mutation in CSF2RB gene in breast cancer 1439 3717 6774 2475 3562 1438 PMC8607372__F1 Cytosolic and nuclear recognition of virus and viral evasion 1283 55601 7706 79132 56919 29110 57506 3661 201292 9208 55308 114548 24138 3434 PMC8607372__F4 Cytosolic and nuclear recognition of virus and viral evasion 3428 115004 29110 3661 PMC8609078__F6 CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway 4345 3716 3717 2885 PMC8610132__F7 miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer 7076 1499 102466726 PMC8613759__F7 CPEB1, a novel risk gene in recent-onset schizophrenia, contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1 4730 64506 4729 PMC8616345__F2 Advances in Immunotherapy and the TGFB Resistance Pathway in Metastatic Bladder Cancer 4092 64750 4089 4087 4088 7018 PMC8618071__F7 Fungicidal Activity of Recombinant Javanicin against Cryptococcus neoformans Is Associated with Intracellular Target(s) Involved in Carbohydrate and Energy Metabolic Processes 5132 1431 3045 100187828 PMC8619591__F1 Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis 3454 3716 7297 10379 3455 2475 3459 3460 3717 3659 PMC8620571__F1 An Atypical Case of Congenital Erythropoietic Porphyria 7390 7389 1371 5498 2235 211 212 210 3145 PMC8623313__F1 Kinase-Inhibitors in Iodine-Refractory Differentiated Thyroid Cancer—Focus on Occurrence, Mechanisms, and Management of Treatment-Related Hypertension 5979 2475 100379198 PMC8623813__F1 Clinical Translation of Combined MAPK and Autophagy Inhibition in RAS Mutant Cancer 4609 2353 3725 7030 PMC8624719__F3 Innate Immune Antagonism of Mosquito-Borne Flaviviruses in Humans and Mosquitoes 3454 3716 6773 6772 7297 3455 10379 PMC86258__F8 Shc/Grb2/Gab2/PI-3K Akt pathway 3600 3567 3562 2885 126669 9846 PMC8627049__F7 Integrated DIA proteomics and lipidomics analysis on non-small cell lung cancer patients with TCM syndromes 255738 3949 27329 4023 7038 9588 5091 230 PMC8629895__F9 Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells 83939 468 83667 114548 79792 3553 PMC8630185__F1 Hemodialysis biocompatibility mathematical models to predict the inflammatory biomarkers released in dialysis patients based on hemodialysis membrane characteristics and clinical practices 7450 4015 715 716 717 PMC8632942__F6 Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease 3455 3716 3717 3659 9636 4938 26136 3454 7297 6773 3665 3460 3459 64135 3434 6772 163702 PMC8634458__F1 Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer 115004 29110 3661 PMC8637576__F6 Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes 3082 64781 3458 3558 100187761 PMC8639566__F1 Sensing Stemness 57506 7189 3665 3661 115004 PMC8642436__F6 A potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway 2475 3156 2194 PMC8642801__F1 DR-5 and DLL-4 mAb Functionalized SLNs of Gamma-Secretase Inhibitors- An Approach for TNBC Treatment 54567 4609 441478 PMC8646611__F5 Rapid Detection and Inhibition of SARS‐CoV‐2‐Spike Mutation‐Mediated Microthrombosis 3273 2266 6347 3569 6403 335 2162 2243 213 5045 5054 6667 3674 351 3162 7099 7097 7852 PMC8647069__F8 COVID-19 with obliterating endothelialitis associated with complement activation and accumulation of C5aR1-expressing macrophages around vessels 9332 968 59272 PMC8649885__F1 Schematic showing the reported genetic determinants of human EEA and EEAF 347688 154288 4342 79816 126206 55655 353238 PMC8659385__F4 Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses 1950 2475 1956 PMC8662531__F4 Aging and the cGAS-STING pathway 11277 1777 29110 3661 115004 PMC8662602__F1 Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation 8737 11035 197259 81030 PMC8662819__F1 Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer 7472 5133 3902 PMC8670088__F3 Triangle Relationship Between Long Noncoding RNA, RIG-I-like Receptor Signaling Pathway, and Glycolysis 57506 29110 3661 PMC8673831__F4 SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes 768214 7466 4023 6928 1030 2169 PMC8674309__F3 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment 7098 115004 941 942 3661 6772 6773 PMC8674309__F4 Antiviral Responses in Cancer: Boosting Antitumor Immunity Through Activation of Interferon Pathway in the Tumor Microenvironment 10379 6772 3661 3665 3458 PMC8674571__F1 The Immune System in Health and Disease by Members of the Bone Morphogenetic Protein Family 4086 90 94 658 657 4089 4090 7189 9618 PMC8679799__F1 Human NLRP1: From the shadows to center stage 22861 79792 3553 91039 PMC8684694__F7 Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway 3569 2717 6774 1869 PMC8693863__F7 ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion 4656 389827 5879 PMC8696218__F5 Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells 6774 4609 4313 PMC8703276__F1 Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks 4524 1719 4397 100188776 875 PMC8705789__F3 The Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries 2475 5728 1493 PMC8706107__F1 HPV16 Entry into Epithelial Cells: Running a Gauntlet 5371 3458 115004 339344 6672 PMC8714916__F1 Visualizing Cancer Cell Metabolic Dynamics Regulated With Aromatic Amino Acids Using DO-SRS and 2PEF Microscopy 355 2308 7942 7030 PMC8720965__F4 Disorders of Sex Development of Adrenal Origin 1646 5447 8644 PMC8721229__F4 Differential Effects of Propylthiouracil and Methimazole as Graves’ Disease Treatment on Vascular Atherosclerosis Markers: A Randomized Clinical Trial 5728 3383 7412 PMC8728240__F2 Priority index: database of genetic targets in immune-mediated disease 4609 7054 266710 7186 5371 100187761 4397 PMC8732860__F7 Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation 3146 7097 114548 79792 PMC8738154__F5 Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer 4763 1950 1956 5163 2475 5728 PMC8745310__F3 Ubiquitin Signaling in Innate Immune Response by Herpesviruses 9447 22861 3428 79184 7874 55031 10425 11074 PMC8745771__F1 Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair 983 5347 991 324 PMC8747952__F1 An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19) 6868 6774 9021 PMC8750547__F1 Long Noncoding RNAs Regulate the Inflammatory Responses of Macrophages 7099 4615 7189 100507246 114614 23152 100124700 PMC8750814__F2 Elucidating T Cell and B Cell Responses to SARS-CoV-2 in Humans: Gaining Insights into Protective Immunity and Immunopathology 604 3458 958 51311 51284 939 643 2638 PMC8752619__F4 Transcriptional alterations in bladder epithelial cells in response to infection with different morphological states of uropathogenic Escherichia coli 23172 8553 10628 57506 114548 6097 2908 5027 PMC8752802__F6 IFNG signaling integrity in colorectal cancer immunity and immunotherapy 4283 3627 6772 2146 3716 3717 3459 PMC8753223__F7 Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation 51119 9242 4280 4599 3479 6387 PMC8756491__F1 Biallelic variants in MESD, which encodes a WNT-signaling-related protein, in four new families with recessively inherited osteogenesis imperfecta 7473 324 7471 50964 22943 23184 4280 3949 4040 4041 PMC8762220__F2 Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer 2040 652 658 3717 7291 9242 PMC8766727__F6 USP14: Structure, Function, and Target Inhibition 84166 9097 1499 4851 PMC8773595__F2 Clinical Significance of the Duality of Wnt/Beta-Catenin Signaling in Human Hepatocellular Carcinoma 324 4040 4041 1499 2932 6925 PMC8783605__F3 Peripheral nerve stimulation and immunity: the expanding opportunities for providing mechanistic insight and therapeutic intervention 4922 1392 7124 3553 PMC8786143__F1 Quantitative Alterations in Complement Alternative Pathway and Related Genetic Analysis in Severe Phenotype Preeclampsia 1401 718 720 717 721 2271 7448 727 3078 PMC8786307__F2 Inflammasome-independent signalling by NLR proteins in the intestinal epithelium during CRC 4671 197358 6774 79671 91662 2475 9447 PMC8790423__F2 Statin as a therapeutic agent in gastroenterological cancer 387 2078 367 PMC8791723__F1 Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease 8942 3620 169355 8564 130013 PMC8798099__F4 Gene network screening of bladder cancer via modular analysis 8564 5447 1611 675 7015 260431 1311 PMC8799879__F1 Symphony of nanomaterials and immunotherapy based on the cancer–immunity cycle 355 325 920 941 942 940 PMC8801368__F1 Progesterone Receptors in Breast Cancer 6387 7852 54361 PMC8801576__F8 Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway 920 3458 3002 7040 3586 PMC8802069__F9 Activation of Autophagy Through the NLRP3/mTOR Pathway: A Potential Mechanism for Alleviation of Pneumonia by QingFei Yin 2475 6693 114548 834 PMC8802512__F2 The S100 protein family in rheumatoid arthritis 114609 1385 100379198 PMC8804138__F3 Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?—a review 4018 717 3146 PMC8804234__F3 Molecular Mechanisms of Clonorchis sinensis-Host Interactions and Implications for Vaccine Development 7097 4615 7099 90865 6761 25805 PMC8809092__F7 Suppression of canonical TGFB signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis 4089 4087 4088 10873 2626 4092 PMC8809485__F2 Gaucher Disease: Basic and Translational Science Needs for More Complete Therapy and Management 7942 7030 3553 114548 29110 100187761 8737 11035 6009 PMC8816937__F7 Schematic diagram showing that the ETV4 functions in HCC metastasis 1856 2118 4609 1499 4316 PMC8818415__F8 Bioinformatic Analysis of the Effect of the Sirtuin Family on Differentiated Thyroid Carcinoma 2717 8544 5728 2475 759 666 PMC8819303__F2 Aberrant RNA splicing and therapeutic opportunities in cancers 84844 23451 23450 11338 7307 6427 PMC8824786__F1 Functional TGFB1 polymorphism in the donor associates with long-term graft survival after kidney transplantation 7046 7048 4089 4088 4087 PMC8830302__F1 Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy 3091 1493 3902 50943 3458 PMC8831562__F3 USPs and TGFB signalling 1540 2932 4089 4087 4088 83844 9958 64750 4092 7375 PMC8833116__F10 Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma 10574 619501 174 PMC8833126__F9 Novel pyroptosis-related signature predicts prognosis and response to treatment in breast carcinoma 1660 27177 3606 56300 26291 2697 56169 196527 3661 2309 114548 1687 3002 2633 PMC8833717__F3 Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer 572 581 331 355 PMC8834070__F2 Shifting the Focus of Signaling Abnormalities in Colon Cancer 1950 1956 2885 PMC8834581__F3 Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle 6714 22974 2638 PMC8836889__F3 Promoting Apoptosis, a Promising Way to Treat Breast Cancer With Natural Products: A Comprehensive Review 2475 596 2932 PMC8850271__F1 Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease 25801 1581 8213 1593 PMC8850271__F2 Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease 9965 2264 1581 PMC8851069__F2 Advances in cGAS-STING Signaling Pathway and Diseases 115004 54106 4615 PMC8851069__F6 Advances in cGAS-STING Signaling Pathway and Diseases 1777 11277 115004 PMC8855721__F7 Potential mechanism of the effects of HF-MSCs in the treatment of LC 4089 59 4087 4088 PMC8856111__F1 CounterAKTing HIV: Toward a “Block and Clear” Strategy? 7852 7251 920 5728 2146 50943 2475 PMC8856628__F1 Mechanism of action of GEM in PDAC treatment 978 1635 1633 6240 PMC8860897__F1 Immune Checkpoint Inhibitors in Tumors Harboring Homologous Recombination Deficiency: Challenges in Attaining Efficacy 140885 2539 961 6772 6774 3659 3661 PMC8861201__F1 Metabolic Engineering for Valorization of Agri- and Aqua-Culture Sidestreams for Production of Nitrogenous Compounds by Corynebacterium glutamicum 9241 4118 11113 PMC8861264__F8 Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy 79188 115004 472 7157 7045 9518 7040 3958 1462 4000 PMC8867516__F1 Rare Autoinflammatory Diseases 115004 6773 29110 3454 3455 7297 3716 6772 3661 PMC8869286__F1 Identification of Targetable Liabilities in the Dynamic Metabolic Profile of EGFR-Mutant Lung Adenocarcinoma: Thinking beyond Genomics for Overcoming EGFR TKI Resistance 3082 3949 1956 2194 857 PMC8869658__F1 Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris 51199 100188011 100 132 353 4907 PMC8872821__F1 Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’ 267 6346 10252 PMC8876671__F2 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance 57167 648 5728 PMC8879474__F5 Tissue Transglutaminase but Not Microbial Transglutaminase Is Inhibited by Exogenous Oxidative Substances in Celiac Disease 920 324 3458 PMC8882093__F2 Helicobacter pylori and gastric cancer: a lysosomal protease perspective 3240 4170 6714 6387 9547 58191 6348 6352 6347 6351 PMC8883233__F2 MCL1-mediated regulation of apoptosis 637 4170 596 581 PMC8888757__F8 Proposed simplified model of ADAP1-mediated T cell signaling stimulation leading to latent HIV-1 reactivation 213 11033 3845 940 3725 2353 PMC8895153__F4 SUMOylation in Viral Replication and Antiviral Defense 115004 6612 7341 10475 59343 57337 29110 3661 PMC8895238__F1 Hypoxia in the Interferon Response 7098 57506 29110 3661 115004 3428 51428 3716 6773 6772 3454 3455 7297 10379 3665 103 PMC8898366__F9 PrPC Promotes Endometriosis Progression by Reprogramming Cholesterol Metabolism and Estrogen Biosynthesis of Endometrial Stromal Cells through PPARA Pathway 5465 19 3156 PMC8898846__F4 Comprehensive Analysis of Immune Infiltrates of Ferroptosis-Related Long Noncoding RNA and Prediction of Colon Cancer Patient Prognoses 4397 387569 6955 2520 351 367 324 2353 4609 581 9118 51426 PMC8900363__F7 Increased phosphatase regenerating liver-1 trigger vascular remodeling in injured ovary via platelet-derived growth factor signaling pathway 2475 5159 6714 8322 268 135935 9210 1956 PMC8902906__F3 Biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19 3458 6364 2919 PMC8904073__F7 Dickkopf-3 and Beta-catenin play opposite roles in the Wnt/Beta-catenin pathway during the abnormal subchondral bone formation of human knee osteoarthritis 4040 4041 324 2932 27122 1499 PMC8908284__F3 Dualistic role of platelets in living donor liver transplantation: Are they harmful? 3082 3479 6774 595 PMC8913072__F8 Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling 1280 6662 4322 2475 9518 596 PMC8913803__F2 Signaling pathways and targeted therapy for myocardial infarction 60674 5728 2932 2146 1431 4855 4853 4851 4854 100188776 58494 PMC8914027__F1 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway 51311 51284 7098 4615 7189 57506 7187 7706 29110 6773 7297 6772 10379 3454 3455 3716 PMC8914027__F4 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway 7098 4615 29110 7187 7189 PMC8914027__F7 Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway 51311 51284 7098 4615 158800 57506 7189 7187 101927851 283131 7706 29110 100506779 7297 100505994 5820 100506860 6773 6772 10379 3454 3455 3716 100506668 104326052 PMC8914548__F11 TFPI2 suppresses the interaction of TGFB2 pathway regulators to promote endothelial–mesenchymal transition in diabetic nephropathy 64750 4092 7046 7048 4089 4088 4087 PMC8919643__F4 Untargeted metabolomics analysis of esophageal squamous cell cancer progression 79888 9791 5091 5183 PMC8920499__F1 Expression levels of sonic hedgehog pathway genes and their targets are upregulated in early clear cell renal cell carcinoma 6469 4609 51684 596 5727 2736 2737 6608 7422 55733 595 2735 PMC8924142__F1 Type I interferon-mediated tumor immunity and its role in immunotherapy 3454 3455 7297 3716 6773 6772 10379 2475 PMC8924449__F9 Transcriptomic and Metabolomic Analyses Reveal Key Metabolites, Pathways and Candidate Genes in Sophora davidii (Franch.) Skeels Seedlings Under Drought Stress 80758 1999 847 7498 3242 5604 5625 PMC8927915__F1 Teaching cancer imaging in the era of precision medicine: Looking at the big picture 1950 1956 324 PMC8929692__F4 Major metabolic pathways upregulated in the cells utilizing 3-hydroxybenzoate, 4-hydroxybenzoate or hydroquinone as a sole carbon source 1674 23269 6651 1325 100653365 126669 4099 1636 847 130749 PMC8938628__F1 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway 324 607 2932 4040 4041 1499 PMC8940899__F7 MiR-323a-3p inhibits gefitinib resistance acquisition by targeting ErbB3/PI3K/Akt-EGFR/Erk1/2 signaling in colorectal cancer 1956 2065 2932 PMC8945569__F2 Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review 114548 140609 3553 PMC8946206__F2 Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future 2475 1950 1956 5155 PMC8946699__F1 New Directions and Challenges in Targeted Therapies of Advanced Bladder Cancer: The Role of FGFR Inhibitors 100187907 5728 5228 2475 PMC8947839__F4 Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review 2308 4318 3553 PMC8948957__F2 Combined Targeted and Untargeted Profiling of HeLa Cells Deficient in Purine De Novo Synthesis 471 158 5471 10606 7808 2618 5198 PMC8949402__F2 Immune Escape Mechanism and Vaccine Research Progress of African Swine Fever Virus 3717 7098 115004 PMC8952333__F6 Advances in HIV-1 Assembly 5045 115362 8826 PMC8953107__F6 Fucoidan (Undaria pinnatifida)/Polydopamine Composite-Modified Surface Promotes Osteogenic Potential of Periodontal Ligament Stem Cells 5289 5728 5266 PMC8960601__F2 Immunomodulatory Activity of Mesenchymal Stem Cells in Lupus Nephritis: Advances and Applications 9242 7852 6347 6774 5132 PMC8960635__F3 Hyaluronan, a double-edged sword in kidney diseases 3037 3038 3036 6774 3716 PMC8960869__F8 Mechanism by which HORMAD1 functions to promote the malignant phenotypes of lung cancer cells 84072 324 1499 51176 595 4316 4318 PMC8964100__F8 Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway 6774 1277 641 PMC8969440__F7 Cordyceps militaris Modulates Intestinal Barrier Function and Gut Microbiota in a Pig Model 7099 114609 4615 7189 PMC8972277__F5 Aspirin attenuates liver fibrosis by suppressing TGFB1/Smad signaling 4087 4089 4088 PMC8973533__F5 Carbohydrate regulation response to cold during rhizome bud dormancy release in Polygonatum kingianum 51083 2592 7360 101448070 2582 412 4200 PMC8980962__F2 JAK/STAT: Why choose a classical or an alternative pathway when you can have both? 6774 7297 6773 6775 3717 149233 3716 PMC8987592__F2 TGFB/Smad Signaling Pathway in Tubulointerstitial Fibrosis 4087 4088 7046 4089 4092 PMC8987729__F8 Temporal Control of the WNT Signaling Pathway During Cardiac Differentiation Impacts Upon the Maturation State of Human Pluripotent Stem Cell Derived Cardiomyocytes 4633 6910 58498 7135 2626 7139 2627 4625 9464 948 1349 1339 23493 1482 3759 775 488 348980 PMC8989153__F1 Heterogeneous Causes of Cushing Syndrome Resulting From Primary Macronodular Adrenal Hyperplasia (PMAH) 23028 2696 4158 3363 7216 79798 3360 554 3973 PMC8997719__F6 Total and Mitochondrial Transcriptomic and Proteomic Insights into Regulation of Bioenergetic Processes for Shoot Fast-Growth Initiation in Moso Bamboo 2597 2821 4118 1431 5132 1737 4967 PMC9002106__F3 Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials 8161 920 7124 114548 PMC9005749__F2 CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy 201633 2885 10666 PMC9011227__F1 Lipid rafts in persistent Helicobacter pylori infection: a narrative review 6772 3716 4283 PMC9023592__F1 Product of AS of pre-mRNA: lncRNA 3458 6935 4149 8519 3434 2537 PMC9024452__F6 Restricted Activation of the NFKB Pathway in Individuals with Latent Tuberculosis Infection after HIF-1A Blockade 7097 1594 5212 3606 PMC9025601__F3 Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex 7161 1356 1571 7124 PMC9028270__F2 Regulatory Processes of the Canonical Wnt/Beta-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair 2932 324 1499 PMC9030409__F4 Personalized Diagnosis in Differentiated Thyroid Cancers by Molecular and Functional Imaging Biomarkers: Present and Future 2064 2475 673 6528 5156 50507 23476 PMC9032563__F1 Mapping Molecular Networks within Clitoria ternatea Linn. against LPS-Induced Neuroinflammation in Microglial Cells, with Molecular Docking and In Vivo Toxicity Assessment in Zebrafish 7408 387 6010 PMC9033378__F6 Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques 1356 6520 7018 5094 55240 2182 PMC9033378__F7 Psoriasis Vulgaris of Blood Heat Syndrome in Plasma Based on Widely Targeted Techniques 1356 81888 5091 5550 1690 PMC9037381__F2 Pathogenic Mechanisms of Fusobacterium nucleatum on Oral Epithelial Cells 541471 208 6615 PMC9046545__F10 Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review 2260 4827 2263 2261 695 PMC9047778__F2 Providing a Helping Hand: Metabolic Regulation of T Follicular Helper Cells and Their Association With Disease 643 2475 604 940 29851 PMC9047912__F1 Genetic Polymorphisms in microRNA Genes Targeting PI3K/Akt Signal Pathway Modulate Cervical Cancer Susceptibility in a Chinese Population 7189 8517 1398 867 1399 596 PMC90529__F7 Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray 3652 3398 10229 PMC9061988__F1 Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies 729 1431 2271 735 966 PMC9062100__F4 Toll-Like Receptors and Th Responses in Viral Myocarditis 7098 7189 7099 7097 7054 PMC9065418__F1 Association of TGFB Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections 7046 4087 4088 4089 3240 4091 4090 4086 PMC9065611__F5 Data of RNA-seq transcriptomes of liver, bone, heart, kidney and blood in klotho mice at a pre-symptomatic state and the effect of a traditional Japanese multi-herbal medicine, juzentaihoto 211 212 5498 2235 210 7909 1371 3145 7390 7389 PMC9066095__F3 New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials 619501 148189 89780 1499 PMC9069765__F8 EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway 54472 9775 5090 619501 1292 5806 4148 1490 PMC9072078__F7 Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells 3550 4615 7189 PMC9078765__F5 Utilizing Network Pharmacology and Molecular Docking Integrated Surface Plasmon Resonance Technology to Investigate the Potential Targets and Mechanisms of Tripterygium wilfordii against Pulmonary Artery Hypertension 7054 1611 4117 351 PMC9082421__F4 Transcriptome and iTRAQ-Based Proteome Reveal the Molecular Mechanism of Intestinal Injury Induced by Weaning Ewe's Milk in Lambs 933 290 1380 931 7037 55652 145226 316 6319 51703 2168 1543 1962 123 4973 1622 PMC9084694__F2 Single‐cell profiling of transcriptomic changes during in vitro maturation of human oocytes 7408 3006 4843 79923 3091 8338 3110 3398 PMC9089305__F8 Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway 9817 2729 3162 PMC9092267__F8 De novo variants of CSNK2B cause a new intellectual disability-craniodigital syndrome by disrupting the canonical Wnt signaling pathway 1857 1460 1499 PMC9094075__F1 Drug resistance in targeted cancer therapies with RAF inhibitors 1950 1956 2885 673 PMC9096244__F2 Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma 84962 595 1029 55294 7157 2064 1956 2475 PMC9096795__F5 Hereditary Systemic Autoinflammatory Diseases: Therapeutic Stratification 3716 4434 51816 PMC9097439__F2 Regulatory role of short-chain fatty acids in inflammatory bowel disease 7097 7099 4615 3654 51135 7189 114548 PMC9099016__F3 LncRNAs and CircRNAs in cancer 221883 93986 894 55384 90632 7503 641638 PMC9099292__F7 Transcriptome Analysis Reveals the Molecular Response to Salinity Challenge in Larvae of the Giant Freshwater Prawn Macrobrachium rosenbergii 112724 3148 84654 PMC9102649__F4 Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non‐small cell lung cancer cells via p53‐p21 signaling pathway 1021 1019 1017 113130 PMC9102749__F6 System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats 126669 1610 7018 596 3880 1509 5447 5914 PMC9105267__F1 CXCR4/CXCL12 Activities in the Tumor Microenvironment and Implications for Tumor Immunotherapy 7852 57007 6387 57580 5879 952 324 7535 961 140885 PMC9107748__F3a Transcriptome profiling and proteomic validation reveals targets of the androgen receptor signaling in the BT-474 breast cancer cell line 580 6418 2066 4609 PMC9107782__F1 Manipulating the Wnt/Beta-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapy 64840 4040 4041 324 2932 1499 51176 22943 PMC9107782__F6 Manipulating the Wnt/Beta-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapy 22943 4040 4041 81693 324 64840 1499 PMC9114368__F8 Illustrative model to show the mechanism of circLIFR in HCC 27161 1499 619501 PMC9117624__F3 Association Between Neddylation and Immune Response 4615 23586 7189 57506 7187 29110 3661 3665 115004 PMC9117704__F2 Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms 5728 6774 5111 581 664 PMC9118275__F3 MicroRNA-96: A therapeutic and diagnostic tumor marker 26959 6424 2932 1499 4885 324 PMC9136039__F6 Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer 3579 3577 3576 2921 5284 7033 324 124220 2520 PMC9136126__F6 Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model 10803 6370 6356 11001 2172 10062 581 PMC9136176__F3 Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways 1956 3717 6774 PMC9139342__F9 Mediating EGFR-TKI Resistance by VEGF/VEGFR Autocrine Pathway in Non-Small Cell Lung Cancer 1950 1956 3091 387 5879 3845 7249 7248 6009 2475 PMC9140097__F1 Chromosomal Instability in Chronic Myeloid Leukemia: Mechanistic Insights and Effects 613 100187761 6741 2638 PMC9141140__F4 Rare Variant Analysis and Molecular Dynamics Simulation in Alzheimer’s Disease Identifies Exonic Variants in FLG 23621 351 2312 100187761 PMC9146749__F7 Infectious Bronchitis Virus Nsp14 Degrades JAK1 to Inhibit the JAK-STAT Signaling Pathway in HD11 Cells 3716 6772 3717 PMC9149322__F8 Illustration of the mechanism of EEZS-induced apoptosis in human bladder cancer T24 cells 596 581 355 637 PMC9155920__F3 Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling 2932 9817 4092 PMC9157768__F7 Extracellular Vesicles From Stored Red Blood Cells Convey Heme and Induce Spic Expression on Human Monocytes 571 121599 7099 1524 PMC9162151__F3 Pathogenesis and treatment of multiple myeloma 3479 572 2932 2475 PMC9164466__F7 FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion 79792 2176 3553 PMC9167543__F2 MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer 100500828 7471 3725 324 2932 1499 693210 693149 PMC9168125__F1 Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy? 117581 924 6667 PMC9170928__F8 Chicken telomerase reverse transcriptase mediates LMH cell pyroptosis by regulating the nuclear factor-kappa B signaling pathway 3458 284110 114548 3553 PMC9170998__F3 Traditional Uses, Phytochemistry and Biological Activities of Alocasia Species: A Systematic Review 1019 331 317 PMC9174896__F2 Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years 652 324 1847 10097 PMC9178561__F6 First study on the effect of crocodile oil from Crocodylus siamensis on hepatic mitochondrial function for energy homeostasis in rats 1080 57521 2618 1978 253260 207 6198 2475 47 81932 PMC9179436__F1 Indoleamine 2, 3-Dioxygenase 1 in Regulating Tumor Microenvironment 3716 3717 7297 6773 PMC9179486__F1 Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated 125061 8564 8942 23475 PMC9179857__F3 Loss of CHGA Protein as a Potential Biomarker for Colon Cancer Diagnosis: A Study on Biomarker Discovery by Machine Learning and Confirmation by Immunohistochemistry in Colorectal Cancer Tissue Microarrays 2040 5800 6678 PMC9179967__F4 Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling 5727 2737 6469 6608 891 PMC9180999__F4 PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity 10084 3661 3569 7124 115004 PMC9187756__F4 Various roles of p53 in ferroptosis 5743 246 6541 239 2182 23657 1026 1803 27035 PMC9189780__F8 DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway 3065 1844 116092 4313 PMC9196867__F1 Current Concepts on Pathogenic Mechanisms and Histopathology in Cutaneous Lupus Erythematosus 5132 4615 7124 115004 29110 6955 2833 PMC9204329__F1 Of DEK proto-oncogene as a prognostic biomarker for colorectal cancer: An evidence-based review 7913 1499 581 PMC9204334__F1 Molecular Role of IL-35 in Non-Small Cell Lung Cancer 50943 1499 10148 6772 6774 PMC9205143__F4 Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders 5218 6955 541471 56674 PMC9207355__F7 CEMIP promotes extracellular matrix‐detached prostate cancer cell survival by inhibiting ferroptosis 57214 9817 3710 23657 PMC9214809__F8 Selective PPARD agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway 5467 26291 1581 PMC9217774__F3 Serial Tumor Molecular Profiling of Newly Diagnosed HER2-Negative Breast Cancers During Chemotherapy in Combination with Angiogenesis Inhibitors 3845 369 3815 545 6651 5979 PMC9226676__F2 Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications 100188776 182 23462 PMC9230939__F2 Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia 1956 196 405 PMC9237220__F1 Different Immunoregulation Roles of Activin A Compared With TGFB 4087 4088 4089 5080 2475 PMC9237470__F1 Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response 6608 51684 6469 PMC9237470__F2 Basal Cell Carcinoma and Hedgehog Pathway Inhibitors: Focus on Immune Response 5727 6608 51684 PMC9240865__F2 Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease 4018 79143 5091 PMC9241180__F7 circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer 9788 2932 1499 PMC9250990__F1 T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease 3458 54106 7097 5132 324 3661 115004 51284 PMC9252758__F2 Flavonoids Targeting the mTOR Signaling Cascades in Cancer: A Potential Crosstalk in Anti-Breast Cancer Therapy 7249 7248 6009 165918 PMC9253381__F5 Elabela Attenuates the TGFB1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis 4087 4088 4089 PMC9261367__F6 T-Cell Aging-Associated Phenotypes in Autoimmune Disease 4855 5868 8766 PMC9263262__F1 MicroRNA/lncRNA Intertwined With the Wnt/Beta-Catenin Axis in Regulating the Pathogenesis of Triple-Negative Breast Cancer 4040 4041 2932 1499 324 595 PMC9266551__F3 Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2 7124 3959 7189 7187 29110 3661 PMC9266588__F3 Amino acid biosynthesis in Cyclocarya paliurus 2597 1431 7086 5226 PMC9266896__F1 Interleukin 15 in Cell-Based Cancer Immunotherapy 3601 3716 6774 3718 PMC9266941__F1 Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification 650 4090 4086 4089 4087 PMC9274081__F2 Inflammation in Cardiac Remodeling After Acute Myocardial Infarction 114548 3553 1401 PMC9274486__F8 miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer 5600 6009 2475 1956 PMC9279758__F6 CD44 potentiates hepatocellular carcinoma migration and extrahepatic metastases via the AKT/ERK signaling CXCR4 axis 960 7852 6387 PMC9280125__F1 Homocysteine Metabolism in Pregnancy and Developmental Impacts 1719 4524 4397 635 875 191 PMC9280743__F7 Mechanism and therapeutic strategy of hepatic TM6SF2-deficient non-alcoholic fatty liver diseases via in vivo and in vitro experiments 53345 2194 1374 PMC9282876__F7 Sanguinarine Regulates Tumor-Associated Macrophages to Prevent Lung Cancer Angiogenesis Through the WNT/Beta-Catenin Pathway 7471 4040 4041 324 7476 7477 7480 1499 PMC9284495__F7 Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1A/TGFB1/SMAD pathway 4089 4088 4087 PMC9284900__F8 METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner 56339 29102 27123 1499 PMC9289374__F1 Gene expression profile of epithelial–mesenchymal transition in tumours of patients with nonsmall cell lung cancer: the influence of COPD 4087 4088 4089 9839 7291 6615 999 4312 1000 3383 4318 PMC9289867__F4 Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways 84890 100187761 8066 PMC9290266__F8 RA signaling pathway combined with Wnt signaling pathway regulates human-induced pluripotent stem cells (hiPSCs) differentiation to sinus node-like cells 6331 9096 5308 652 6910 10021 8913 6474 6926 PMC9290485__F3 Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity 140805 1565 1576 1557 1559 1555 1544 4099 PMC9293526__F7 miR-26a-5p Suppresses Wnt/Beta-Catenin Signaling Pathway by Inhibiting DNMT3A-Mediated SFRP1 Methylation and Inhibits Cancer Stem Cell-Like Properties of NSCLC 1788 6422 4609 1499 PMC9300530__F3 Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli 4118 11113 4330 5225 51083 PMC9312859__F7 FGFR2c/PKCE Axis Controls MCL-1-Mediated Invasion in Pancreatic Ductal Adenocarcinoma Cells: Perspectives for Innovative Target Therapies 4170 2247 2475 PMC9313271__F1 Current Concepts of Vitiligo Immunopathogenesis 2833 4283 3627 3717 PMC9313346__F2 P2 Receptors: Novel Disease Markers and Metabolic Checkpoints in Immune Cells 24145 941 940 2475 324 PMC9318090__F2 Scheme of molecules and pathways involved in DR and their relationship 55908 51129 4040 PMC9318993__F7 Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing 7099 2314 4615 PMC9319825__F1 Emerging Biomarker-Guided Therapies in Prostate Cancer 367 2475 5728 PMC9323564__F16 Altered Transcriptional Regulation of Glycolysis in Circulating CD8+ T Cells of Rheumatoid Arthritis Patients 2597 6888 414328 3419 4967 1738 55967 4716 54539 509 10632 440567 1337 PMC9324529__F1 Immunosuppressive Mechanisms in Brucellosis in Light of Chronic Bacterial Diseases 7097 51311 1956 7099 6504 942 941 PMC9326442__F4 Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome 6774 3479 3480 2475 PMC9331520__F3 Tumor microenvironment involvement in colorectal cancer progression via Wnt/Beta-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance 7472 3082 6387 1499 PMC9331520__F4 Tumor microenvironment involvement in colorectal cancer progression via Wnt/Beta-catenin pathway: Providing understanding of the complex mechanisms of chemoresistance 324 1499 2932 3082 PMC9331826__F3 Epithelial–Mesenchymal Transition-Mediated Tumor Therapeutic Resistance 728192 79923 1499 558 1956 9201 PMC9331965__F1 IRIDA Phenotype in TMPRSS6 Monoallelic-Affected Patients: Toward a Better Understanding of the Pathophysiology 151176 3077 7018 7036 4089 654 60 3569 3717 6774 PMC9332329__F2 Interactions between phages and immune system components are varied and complex 54106 7098 4615 7097 7096 10333 9447 2152 7054 3596 PMC9332593__F2 DNA Damage Response Regulation by Histone Ubiquitination 672 165918 9025 580 PMC9334593__F6 Pathway for glycine and serine biosynthesis in CC7-B01 response to heat stress 26227 5723 1757 27232 572 635 29958 PMC9334647__F2 Caveolin-1 in Sepsis – A Mini-Review 5879 7422 857 PMC9334758__F2 Eliciting pyroptosis to fuel cancer immunotherapy: mechanisms and strategies 79792 3001 55876 3002 1687 56169 PMC9337250__F2 Bile acids and sphingolipids in non-alcoholic fatty liver disease 1593 1581 1582 25801 570 9420 4280 PMC9339490__F2 Glioma-neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives (Review) 102 4314 4318 6714 4067 PMC9339612__F1 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer 100505881 64326 6774 8766 1499 647979 PMC9339679__F3 Ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction 84101 2146 1499 23326 960 79923 PMC9345703__F8 Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways 7098 115004 29110 3661 6772 3454 3455 3716 3434 4940 PMC9350707__F4 Immunomodulatory role of T helper cells in rheumatoid arthritis 6778 7124 3553 PMC9354686__F6 Oncogenic Role of miR-217 During Clear Cell Renal Carcinoma Progression 442117 65268 10644 3481 PMC9354743__F2 RNA m6A modification orchestrates the rhythm of immune cell development from hematopoietic stem cells to T and B cells 56339 57721 920 51441 7054 10113 3492 PMC9356005__F3 Underlying mechanism of Treg in skeletal muscle repair and regeneration 90865 374 6347 PMC9356848__F7 Transmembrane Protein ANTXR1 Regulates Gamma-Globin Expression by Targeting the Wnt/Beta-Catenin Signaling Pathway 324 1499 55553 595 PMC9359464__F4 Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host 7096 7097 10333 7099 7100 4615 51311 54106 100188864 7189 51284 PMC9360899__F2 PI3K/AKT signaling pathway in gallbladder carcinoma 5728 355 581 331 PMC9361616__F8 IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis 2309 10410 3082 PMC9364940__F1 Ionizing Radiation-Induced Ferroptosis Based on Nanomaterials 2182 10162 115004 472 2879 23657 PMC9365119__F1 Non-ionotropic NMDAR signaling in neuronal physiology 6714 9722 7442 24145 PMC9367504__F8 Inflammatory Mediators in Colorectal Cancer Hepatic Metastasis 2920 3579 114548 3553 PMC9368906__F4 LncRNA H19 Impairs Chemo and Radiotherapy in Tumorigenesis 283120 1499 960 PMC9376458__F5 Transcriptome Analysis of Dendrobine Biosynthesis in Trichoderma longibrachiatum MD33 79947 3156 4598 4597 9453 2224 PMC9376585__F1 Pyroptosis in inflammation and cancer 114548 79792 9447 22861 58484 PMC9382782__F2 Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation 6778 90865 6347 PMC9385636__F7 Salidroside alleviates hepatic ischemia–reperfusion injury during liver transplant in rat through regulating TLR-4/NFKB/NLRP3 inflammatory pathway 4615 114548 3553 PMC9389037__F1 The macrophage-to-myofibroblast transition in renal fibrosis 6778 3718 4087 4088 4089 6714 PMC9393728__F8 EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway 10399 4609 7124 PMC9406806__F8 Nano Modification of Antrodia Cinnamomea Exhibits Anti-Inflammatory Action and Improves the Migratory Potential of Myogenic Progenitors 8322 7474 1499 1655 6925 7054 1000 PMC9406872__F3 Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer 3549 6469 2735 2736 PMC9408922__F1 Biochemical Hazards during Three Phases of Assisted Reproductive Technology: Repercussions Associated with Epigenesis and Imprinting 6573 875 4524 1719 PMC9409255__F3 Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer 30001 468 79871 83939 PMC9409738__F5 Comprehensive Review on the Anti-Cancer Effects of Oleuropein 1956 2194 2475 7942 PMC9412305__F5 The Innate Immune Response during the Human Papillomavirus Life Cycle 581 57506 29110 3661 115004 PMC9419985__F2 Hematopoietic Stem Cells in Wound Healing Response 7099 4615 7018 2885 6714 PMC9419985__F3 Hematopoietic Stem Cells in Wound Healing Response 7099 4615 7018 2672 PMC9421153__F5 Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma 3569 3570 3553 2247 1950 1956 5228 7422 7010 2475 PMC9427288__F2 Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs 8824 10864 151531 1890 1548 978 1806 7371 7372 5471 6241 1807 7298 PMC9428319__F3 Pathomechanisms of bone loss in rheumatoid arthritis 7054 22943 50964 PMC9441491__F7 Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis 645638 202299 347689 6774 2475 3091 3939 728655 2260 100124700 100188864 400500 3099 494327 6513 10230 3667 7503 PMC9445361__F6 Score of DNA damage repair pathway with the predictive ability for chemotherapy and immunotherapy is strongly associated with immune signaling pathway in pan-cancer 83417 1280 920 4103 7124 PMC9448771__F8 Graphical abstract. NAT10 functions as a negative regulator of neutrophil pyroptosis and a protective factor in sepsis 55226 8408 3661 114548 PMC9450509__F9 DDX56 inhibits PRV replication through regulation of IFNB signaling pathway by targeting cGAS 115004 29110 3661 54606 PMC9454904__F2 Current Understanding of Asthma Pathogenesis and Biomarkers 325 3576 6374 2919 7124 PMC9457923__F1 ABCC4 inhibition as a potential therapeutic strategy against SHH-MB 5727 6608 6469 2736 51684 10257 PMC9469633__F8 Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer 7476 1499 2475 PMC9473879__F9 Network Pharmacology and Experimental Verification Revealed the Mechanism of Yiqi Jianpi Recipe on Chronic Obstructive Pulmonary Disease 6774 3725 1956 2353 3005 PMC9475348__F6 Human placental mesenchymal stem cells regulate inflammation via the NF‑KB signaling pathway 7099 3553 581 PMC9479335__F5 Case report of the sustained and rapid response of bevacizumab in a TP53-positive breast cancer and liver metastatic patient through personalized medicine 5728 4193 2475 PMC9479684__F6 When does hepatitis B virus meet long-stranded noncoding RNAs? 728655 6774 9582 378938 3661 6093 PMC9481960__F1 Knowledge-guided deep learning models of drug toxicity improve interpretation 9760 6714 1956 3065 PMC9489753__F1 Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells 4055 2252 2254 3082 182 PMC9493169__F4 Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect 114548 51284 695 4615 3553 6347 3579 PMC9497807__F2 Polycomb Directed Cell Fate Decisions in Development and Cancer 100170841 2145 2146 23512 121536 84678 3720 84733 PMC9501394__F2 Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review 9817 596 581 PMC9501546__F5 TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway 2260 80727 3265 PMC9503233__F1 Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome 7097 4615 7099 3661 5894 6850 64170 114548 PMC9503463__F1 NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity 64127 114548 7187 3661 PMC9503463__F2 NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity 57506 84166 834 PMC9511797__F1 Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer 7225 6446 6286 PMC9512540__F6 Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer 6772 3716 3717 6373 3627 91543 64135 PMC9513977__F5 Mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress 64902 55349 51268 29958 635 PMC9515028__F2 Possible role of long non-coding RNAs in recurrent miscarriage 283120 4084 100033819 3690 1977 1017 3576 1499 100124700 83959 3606 PMC9520276__AF1 XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression 115004 3661 114548 7040 PMC9525705__F1 mtDNA acts as a DAMP to activate neuroinflammation 114548 3661 3553 54106 7124 PMC9526507__F1 Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer 54567 10683 28514 102 9794 100188776 PMC9526507__F2 Notch Signaling Pathway Contributes to Angiogenesis and Tumor Immunity in Breast Cancer 2303 4851 54567 23493 7124 PMC9526616__F7 Early Development of Cardiac Fibrosis in Young Old-Father Offspring 6943 9096 7490 PMC9530903__F6 Metabolome and transcriptome association analysis revealed key factors involved in melatonin mediated cadmium-stress tolerance in cotton 593 1629 3712 1738 11112 4329 64902 PMC9531511__F3 Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis 3454 8737 11035 197259 115004 7124 PMC9536535__F7 Proposed model of S100A8/9 induction 7099 10148 246778 6774 5734 6279 5739 9923 5319 PMC9536840__F7 Pathway impact and pathology of example disease genome-wide association studies (GWAS) hit 790 5096 55364 PMC9547905__F4 Hybrid network of genetic associations revealed by gene-based association studies and significant partial correlations of detected sphingomyelins, 55304 29956 79603 56848 81537 8879 PMC9554150__F4 Immunopathogenesis and environmental triggers in coeliac disease 3458 3558 3716 6774 7128 100507436 PMC9559204__F8 Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense 207 2475 7942 PMC9561884__F4 Roles and targeting options of TRIM family proteins in tumor 10346 440730 5987 80128 84851 54765 56658 339855 58509 23097 22944 100187761 7454 PMC9561884__F5 Roles and targeting options of TRIM family proteins in tumor 7726 1499 54765 2932 81559 2475 6774 80263 11074 91107 286827 22954 5987 9866 PMC9569803__F19 Glucogallin Attenuates the LPS-Induced Signaling in Macrophages and Protects Mice against Sepsis 7099 5970 4615 7189 355 114548 PMC9573978__F2 Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis 324 4040 4041 1499 2932 PMC9575701__F3 An emerging role for cellular crosstalk in the cancer stem cell niche 4087 4088 4089 100187761 90865 PMC9579717__F6 Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling 64798 64223 1192 PMC9580211__F8 CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK 6010 822 5879 PMC9585190__F7 Metformin on Sonic hedgehog subgroup medulloblastoma progression: In vitro and in vivo studies 6469 6608 2735 51684 PMC9585282__F5 Transcriptomic and metabolic analyses reveal the potential mechanism of increasing steroidal alkaloids in Fritillaria hupehensis through intercropping with Magnolia officinalis 4117 3033 2077 PMC9592927__F3 Emerging role of circular RNAs in drug resistance of non-small cell lung cancer 84985 100302132 11279 1499 1956 6774 PMC9596445__F5 Phenylpropane Metabolic Pathway Illustrates in flavonoids accumulation and lignin synthesis in Populus wilsonii 2152 790 1312 57716 PMC9597307__F1 Venetoclax resistance and solutions 581 958 54106 3845 2305 7054 572 5728 6597 7063 4853 6774 467 3662 PMC9598289__F13 Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H2O2-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway 3717 6774 9817 4094 2932 2475 2534 PMC9599894__F5 Radiotherapy-Related Gene Signature in Prostate Cancer 267 6368 916 8764 923 919 917 214 143662 64787 915 1236 151888 2213 PMC9601711__F1 Hereditary Metabolic Bone Diseases: A Review of Pathogenesis, Diagnosis and Management 120227 1576 7454 1628 7421 3183 8074 PMC9602067__F4 Novel De Novo NFKBIA Missense Mutation Associated to Ectodermal Dysplasia with Dysgammaglobulinemia 613 10913 958 PMC9604794__F15 Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes 4397 7275 1611 4342 8213 PMC9605170__F4 Incorporation of Suppression of Tumorigenicity 2 into Random Survival Forests for Enhancing Prediction of Short-Term Prognosis in Community-ACQUIRED Pneumonia 90865 4615 3654 9618 PMC9735758__F1 IL-1RAP, a Key Therapeutic Target in Cancer 3553 8807 3556 4615 90865 27179 27177 6774 59307 PMC9891206__F2 Targeting STING: From antiviral immunity to treat osteoporosis 115004 29110 3661 PMC98985__F3 Overview of metabolic pathways for glucose and xylose metabolism 6886 7498 7504 PMC1065305__F1 Components of the AhR-mediated lacZ reporter assay 196 405 51083 PMC1087506__F8 IRAK1 functions in the TLR and IL-1B pathway upstream of convergence with the TNFA pathway 4615 51135 7189 7186 2353 3725 8717 PMC125938__F8 An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype 5629 10894 947 PMC1304358__F3 Examples of extreme signaling pathways of the JAK-STAT signaling network 3717 6773 338376 PMC134648__F8 Role of Axin2 in Wnt signal transduction 324 2932 8313 1499 7008 PMC1421310__F1 High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells 4086 4087 4088 PMC1502453__F5 Hoxc8-regulated transcriptional network in vivo 960 1956 1950 3224 1499 1009 4091 4086 4089 PMC152295__F1 The PI metabolic pathway and wortmannin sensitivity 3652 5728 5266 PMC1555658__F2 Cholesterol precursors and facial clefting 6608 6469 22937 PMC1571066__F2 TGFB superfamily signalling pathway (see text for explanation) 4091 4092 4086 4090 4087 4088 4089 PMC1571066__F5 Model of SMAD7 role in control of blood vessel calibre (see text for explanation) 4086 4090 4092 PMC1571327__F6 FGF, Wnt and Tbx3 in epithelial–mesenchymal interactions regulating mammary gland initiation 6926 2255 2260 51176 PMC1599906__F3 TGFB signaling pathway 650 652 655 4838 2885 4087 4088 4090 4086 4091 4092 4089 3065 7018 PMC1602337__F9 TWEAK-Fn14 signaling system may play a role in stroke pathophysiology 7186 7188 7185 7187 PMC165090__F8 Schematic model for the roles of p120 catenin in the signaling pathways leading to growth factor–induced RhoA stimulation and cell migration 387 5879 7410 6714 PMC186326__F7 Model for Fgf18 regulation of long bone growth 2260 2261 2263 3549 6608 8817 PMC1885837__F6 Obstructive nephropathy: insights from genetically engineered animals 4087 4088 387 5340 4089 PMC1892626__F3 Regulation of hypoxia-inducible factor-1A (HIF-1A) and drug interventions currently in use 5728 2475 7428 7852 1956 PMC1974867__F9 Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis 4827 7432 1080 PMC1995566__F7 Oxidative stress initiates a cascade of reactions leading to cell death via one or more sequences of molecular events 572 637 836 842 2021 PMC2083698__F6 Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma 4050 4055 7187 7186 1540 23118 4790 602 PMC213796__F7 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer 23512 8726 2146 PMC2215060__F1a WE GATHER TOGETHER: INSULATORS AND GENOME ORGANIZATION 10664 3481 283120 PMC2254178__F1 Vital Elements of the Wnt-Frizzled Signaling Pathway in the Nervous System 2932 324 1499 PMC2258259__F1 Metabolic pathways involved in pyrimidine metabolism 1723 7372 1719 7371 PMC2267731__F2 BL module: A network visualization of the top 25 scoring genes in BL 5451 4150 581 4602 10010 2335 5054 PMC2376838__F8 LRG-Accelerated Differentiation Defines Unique G-CSFR Signaling Pathways Downstream of PU.1 and C/EBPE That Modulate Neutrophil Activation 2056 7018 6774 PMC2383925__F9 MiRNA model for the molecular pathogenesis of recurrent ovarian cancer 4318 7392 3845 1950 2263 596 673 PMC2423668__F1 Two branches of TLR downstream signaling 4615 7189 3661 PMC2443667__F1 Connections between the SAM cycle, transsulfuration pathway, and glutathione production 4144 27430 635 4548 191 875 1491 2937 2729 2730 PMC2453756__F1 Pathway of murine Th17 differentiation 7054 50943 64806 PMC2515131__F2 Signal transduction events initiated by Kit and FcERI leading to specific mast cell responses, and the integration of these pathways for the synergistic enhancement of mast cell mediator release 3815 126669 27040 2885 PMC2517789__F2 Two pathways from gp130 to hypertrophic gene expression 3976 3977 6772 6774 PMC2543934__F5 PPARG in Type 1/Type 2 T (NK) cell differentiation 2625 3565 6778 3566 6772 3460 6775 PMC2575467__F5 A model of KCNQ1/KCNE1 function in embryogenesis 3753 3784 6663 4286 PMC2576041__F9 The role of the IGF-1/phosphatidylinositol 3-kinase (PI3K)/Akt pathway and atrogin-1 and MuRF-1 in SI-induced atrophy and in the amelioration of atrophy by high-load isometric contractions 3667 6476 2475 PMC2587085__F1 Targeting EGFR and Src Pathways in Head and Neck Cancer 6714 1956 2066 2064 2065 PMC2612083__F1 Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder 2922 4828 1392 551 1325 627 7124 PMC2631376__F3 Hypothalamic Malonyl-Coenzyme A and the Control of Energy Balance 4852 5443 181 355 PMC2633716__F1 Genetic Variation in Calcium Sensing Receptor (CASR) and Risk of Colon Cancer 846 1591 7421 PMC2638772__F9 Model whereby increased Fgfr3 signaling in chondrocytes causes premature synchondrosis closure and unification of ossification centers 650 655 5594 PMC2653380__F3 Schematic representation of bile acid synthesis by the classical neutral pathway 80270 1109 1593 23600 570 PMC2659592__F7 Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor A2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells 4018 3598 4060 6778 5091 3597 PMC2661962__F1 Where Do MAIT Cells Fit in the Family of Unconventional T Cells? 920 912 7704 939 3140 PMC2666387__F7 Proposed Src involvement in HCEC wound healing 1839 6714 1956 2064 PMC2670022__F1 Pharmacological targeting of the serotonergic system for the treatment of obesity 4160 23237 181 5443 4852 PMC2671717__F7 Schematic Overview of Pyrimidine de Novo Synthesis, Salvage, and Degradation.Nucleotides synthesized de novo enter the nucleotide pool and become further converted to nucleic acids and other metabolic intermediates 3630 139596 1356 PMC2673547__F8 Oncogenic Function of ATDC in Pancreatic Cancer Through Wnt Pathway Activation and Beta-catenin Stabilization 2932 1499 324 PMC2695499__F10 Changes in OSM signaling 5008 3572 9180 3716 3717 7297 6774 PMC2695826__F2 Age-Related Decrease in Proteasome Expression Contributes to Defective NFKB Activation during Hepatic Ischemia/Reperfusion 2990 5901 9604 PMC2718437__F4a Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B 5054 5329 5328 5345 5055 5327 5340 PMC2720065__F8 Proposed signaling pathway of mmLDL-induced, TLR4/Syk-dependent ROS generation and proinflammatory cytokine expression 7099 929 6850 4615 PMC2720607__F2 Principal enzymes and substrates of the folate pathway involved in formation of tetrahydrofolate (THF) and its utilisation in the thymidylate cycle 1725 1719 2356 PMC2721253__F2 Modes of neurite growth inhibition of molecules expressed on CNS myelin and oligodendrocytes 4099 652 650 84894 8543 6010 PMC2721285__F1 RAS/MAP kinase signaling pathway 3815 673 4827 PMC2721821__F6 Graphical representation of the Hh signaling pathway in its activated state and possible sites of HPI action 6608 6469 5727 51684 PMC2722335__F1 Adipocyte lineage commitment and terminal differentiation 650 652 4015 PMC2729687__F2 Immunological synapse or the interface between an antigen presenting cell and a T-cell 26191 324 940 1493 50943 PMC2737000__F5 Arachidonic acid metabolism pathway 81579 54677 891 5322 5321 5743 5742 240 10499 5467 1855 2932 1052 PMC2740793__F2 TGFB signaling pathway 4089 4087 1628 PMC2757945__F9 Molecular pathways by which WNT-Beta-Catenin and FGF regulate lung mesenchymal development 2254 1499 51176 595 PMC2760938__F13 Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase CD, Lyn Kinase, and Matrix Metalloproteinases 4018 1839 1956 4067 PMC2763047__F2 The Fibroblast Growth Factor Receptor Signaling Pathway in Non-Small Cell Lung Cancer 1956 3480 7039 3082 3479 2247 374 3481 2254 2069 PMC2763047__F3 Fibroblast Growth Factor Receptor Signaling Pathway as a Mediator of Intrinsic Resistance to EGFR-specific Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer 1956 7039 374 2247 2069 2254 PMC2769198__F2 Smad4: gatekeeper gene in head and neck squamous cell carcinoma 4089 3082 1950 PMC2770656__F4 The tyrosine metabolism pathway where the differentially expressed genes of lung cancer were annotated 1652 3008 100034700 PMC2782081__F1 An overview of miRNA biogenesis 29102 54487 23405 5901 PMC2801624__F1 A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches 57216 4854 5081 4617 PMC2808058__F3 The effects of SOX4 and HOXC6 on Notch pathway activation and metastasis 27122 11197 6423 6422 5663 655 28514 6659 3371 4851 102 PMC2819754__F1 Transcriptional regulation of the differentiation of Th1 cells 324 940 7297 3717 3458 6772 6775 2353 PMC2820251__F2 Innate immune evasion strategies of influenza viruses 7297 3716 9636 6772 6773 PMC2832144__F11 Proposed model for the signal transduction pathways involved in TGFB1-mediated fibroblast-myofibroblast differentiation 1950 1956 3037 960 4089 4087 PMC2832945__F7 Proposed mechanism for B2M mAb inhibition of AR and cell proliferation, survival, and progression through a MAPK/SREBP-1 signaling pathway in prostate cancer cells 567 355 367 PMC2846056__F3 Making the blastocyst: lessons from the mouse 1045 7004 9113 26524 PMC2852600__F2 CD40 responsiveness in Leishmania-infected macrophages: crosslinking of anti-CD40 antibody activates p38 MAPK-induced leishmanicidal function via iNOS2 induction 958 6772 3717 PMC2860379__F2 Genes affecting dystroglycan glycosylation associated with congenital muscular dystrophy 10585 29954 55624 79147 PMC2864807__F2 PPAR Signaling Pathway and Cancer-Related Proteins in Celiac Disease-Associated Tissue Damage 2169 345 34 3158 PMC2874340__F1 Folate cycle, methionine cycle, and transsulfuration pathway 4397 635 4524 875 PMC2880454__F1 Targeting the cancer kinome through polypharmacology 1956 3643 3845 PMC2896914__F2 Multiple genes involved in interferon production and regulation are associated with risk for lupus 5132 51284 51311 54106 3663 7128 7189 10318 3665 PMC2896964__F1 Schematic representation of the possible interactions between HIV-1 and the host miRNA-guided RNA silencing pathway 920 54487 29102 27161 PMC2905036__F2 Schematic diagram depicting the proposed role of bone morphogenetic protein (BMP) signaling pathway, HJV, HFE, and TFR2 in iron sensing and hepcidin regulation in the liver 654 7036 3077 164656 148738 4090 4086 4089 PMC2905036__F3 Schematic diagram depicting the molecular mechanisms by which inflammation activates hepcidin transcription in the liver 654 3569 148738 6774 4090 4086 4089 PMC2911411__F3 Network analysis of BAL proteome changes under baseline conditions 3043 1991 4280 174 4622 PMC2913455__F7 E-selectin–mediated slow rolling 695 6850 4067 2268 3055 960 3383 PMC2920202__F2 Spatial-temporal signals determine the fate of activated CD8+ T cells 920 8320 3398 3600 939 970 914 958 PMC2943133__F2 Toll-like receptor (TLR) signalling is mediated by at least two distinct pathways 4615 114609 7189 51295 3661 4284 PMC2952389__F1 Outline of T-cell development pathway from bone marrow to the thymus 920 7018 960 962 864 64919 PMC2966547__F1 Homocysteine metabolic pathways 4397 4524 635 875 PMC2981456__F1 The estrogen biosynthesis pathway 3283 3292 1545 1312 PMC2981611__F1 Wnt Signaling and Mammary Stem Cells 4041 4040 6259 4920 6714 1499 PMC2998553__F3 Screen shot of the user interfaceofSimmune2.0 27040 5979 7535 PMC2999341__F12 Regulatory PathRNet Only nodes that are close to P38 MAPK Signaling pathway or "S-7" are kept (distance<3) 717 730 718 PMC3009741__F3 Bioinformatics Analysis of Macrophages Exposed to Porphyromonas gingivalis: Implications in Acute vs. Chronic Infections 7097 7099 10392 64127 4615 7124 6347 PMC3013518__F1 Vitamin D3 biotransformation pathway 120227 1593 1594 1591 PMC3033586__F2 Wnt pathway and its regulation of Beta-catenin in stem cells and cancer 324 1499 960 8549 595 PMC3034442__F3 Glycine synthesis and degradation 275 1738 2653 2731 PMC3035137__F2 Effects of Hfe deficiency and the associated low hepcidin and intracellular iron levels on macrophage TLR4 signaling 3077 7099 7097 7098 4118 4615 PMC3042643__F1 EGFR signaling pathway 1956 2885 5728 PMC3047044__F1 Simplified schematic version of the epidermal growth factor receptor (EGFR) signaling cascade 1950 7039 1956 2885 673 PMC3060239__F5 Model of the RBP-ROH/STRA6/JAK/STAT pathway 64220 3717 9021 PMC3068308__F5 TGFB signaling pathway 4092 4087 4088 4089 PMC3070484__F1 iNKT cell autoreactivity: what is “self” and how is it recognized? 325 912 29851 940 958 324 PMC3073847__F1 TGFB signaling pathway TGFB is secreted in a latent form and activation is mediated by several molecules including furin and emilin 11117 5045 7048 94 7046 2022 4087 4090 4086 4089 6885 PMC3077082__F6 Microbial manipulation of receptor crosstalk in innate immunity 6774 7097 7099 4615 PMC3094296__F1 KEGG pathways used for the influence approach 2919 4283 2920 2833 3627 2921 6373 6374 567 6372 4261 3553 7096 5879 3569 7097 7098 7187 29110 3661 6772 PMC3107509__F1 Wnt signaling pathways 7474 7471 387 1499 PMC3111743__F6 Correlation network among processes with activity modified by both OEA and KDS-5104 treatments is shown 948 355 4015 PMC3118659__F13 NAD+ biosynthesis and salvage pathways 23475 93100 10135 PMC3127069__F1 The mTOR-signalling pathway from growth factor receptor through mTOR 5728 6009 2475 PMC3128433__F3 Complement cascade, hemolyisis, and eculizumab 718 1604 966 PMC3137003__F2 The insulin and leptin-melanocortin signaling pathway is responsible for maintaining energy and metabolic balance by controlling appetite 181 4160 5443 PMC3146245__F2 Genetic model for nuage assembly and piRNA pathway genes in mice 54456 56165 23424 221400 122402 84944 79084 PMC3147278__F3 Cross-talk between TLR4 and IL-1 signaling pathways 3552 7189 3717 3569 7099 3554 7850 PMC3147301__F3 Towards an understanding of the adjuvant action of aluminium 90865 7054 4615 114548 PMC3153880__F3 Schematic representation of the effect of conventional treatment (Conv) and novel treatment (TKIs) on tumor behavior through the EGF-EGFR pathway 1950 5091 1956 PMC3155178__F1 Synthesis of Dihydrotestosterone via the Classic and Alternative (Backdoor) PathwaysThe classic pathway of steroidogenesis leading to dihydrotestosterone is shown on the left, and the alternative pathway is shown on the right 1583 1646 1586 5447 3284 3294 3293 PMC3160087__F7 Model of the role of the Nodal and Cripto signaling pathways in mouse XEN cell differentiation 6997 4838 4087 4089 PMC3164150__F1 The insulin receptor (IR) with its two subtypes IR-A and IR-B, the insulin growth factor 1 receptor (IGF-IR) and the hybrid receptors (IGF-1R/IR-A and IGF-1R/IR-B) 3481 3479 3480 PMC3172806__F7 A model of pericyte-induced EC survival signaling 7422 331 7448 PMC3180192__F2 TGFB pathway genes in iMYC cells 10217 1284 4982 7538 4920 1277 6774 4256 2331 3624 4086 1634 4060 5654 7046 7049 29984 1303 25805 5270 5054 PMC3185509__F3 Innate immune evasion mechanisms of HSV 7098 7097 54106 57506 3661 6041 PMC3186711__F8 A model of the role of TLR4 signaling pathways in regulating TNFA expression 7099 4118 4615 7124 PMC3188880__F2 Stat3 interactions in glioma biology 6774 3717 5008 3458 10682 652 3976 PMC3199248__F1 TLR induction of inflammation by parasitic infection 4615 3661 3665 PMC3215775__F1 Molecular mechanisms through the Epidermal Growth Factor Receptor pathway 1950 1956 2885 PMC3227936__F1 EGFR signaling pathway 1950 7039 1839 2885 PMC3227953__F1 PI3K/Akt/mTOR pathway signaling in tumor and vascular endothelial cells 56914 7428 7502 PMC3235907__F1 Clopidogrel activation and platelet aggregation pathways 7450 2147 1544 2149 1576 109 6916 PMC3243790__F1 Regulation of ABCA1 Functions by Signaling Pathways 6774 7124 3569 PMC3259218__F1 Gemcitabine metabolic pathway genetic polymorphisms and response in non-small cell lung cancer patients 9154 9153 2030 978 6240 6241 1633 50484 1635 PMC3279601__F1 The Immunologic Revolution: Photoimmunology 50489 1644 7852 912 90865 PMC3283951__F5 The acetate/mevalonate pathway for the formation of IPP, the basic five-carbon unit of terpenoid biosynthesis 3052 1431 3652 PMC3285038__F1 Schematic of Smads mediated TGFB signaling pathway 7046 4087 4088 4089 PMC3295081__F1 Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models 7099 3716 3717 4615 6651 PMC3306173__F6 Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis 7098 29110 3665 3661 PMC3312677__F8 Genetic pathways involved in the regulation of the Mesp2 pathway 2043 3955 6911 134701 9794 145873 PMC3320973__F8 Wnt signaling regulation induced by cell surface HSPG desulfation during dentinogenesis 80326 55959 23213 1834 PMC3340185__F5 A model for the XIAP-regulated RhoGDI SUMOylation signaling pathway in modulation of cell motility 387 23440 7316 331 PMC3355540__F2 Nuclear receptors and photoreceptor differentiation in mice 1406 6095 6258 6096 27164 5015 10002 7101 10401 PMC3378544__F4 Tamarindus indica Extract Alters Release of Alpha Enolase, Apolipoprotein A-I, Transthyretin and Rab GDP Dissociation Inhibitor Beta from HepG2 Cells 1071 64241 948 3156 337 1581 4023 PMC3382911__F1 Colon cancer cells produce immunoregulatory glucocorticoids 1950 2638 7124 PMC3387493__F1 Dual Aspects of Altered Bone Remodeling in Psoriatic Arthritis 7124 860 695 10507 PMC3390502__F8 Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells 4397 23411 3553 6364 7097 PMC3404840__F2 Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef 3932 324 958 PMC3411967__F1 Cell-proliferative signaling pathways in lung tumors 1956 4893 1950 PMC3418731__F3 Signaling within the JAK-STAT pathway in bovine monocytes and M 3603 3552 3560 3575 3566 3454 3716 3717 7297 2885 6775 6774 6778 6772 6773 PMC3418756__F6 Immune activation in the GBS UTI transcriptome comprises prominent cytokine-cytokine receptor signaling 3627 355 3552 3561 4067 3587 6772 6773 4283 PMC3419830__F1 Mechanisms of action for therapeutic agents in treating or preventing HAE 5340 727 718 PMC3430113__F4 Schematic depicting a central role for transforming growth factor (TGF)B1 signaling in osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis (LCH) 4018 5091 2194 7040 50943 920 2736 6774 PMC3431627__F7 Mechanisms of acquired-resistance to vemurafenib 4893 5159 2261 3480 3845 673 PMC3446895__F5 Arginine Consumption by the Intestinal Parasite Giardia intestinalis Reduces Proliferation of Intestinal Epithelial Cells 847 10950 1647 PMC3459659__F1 Lipopolysaccharide/TLR4 signalling lipopolysaccharide recognition.Notes: Overview of LPS/TLR4 signalling LPS recognition is facilitated by lipopolysaccharide-binding protein and CD14, and is mediated by TLR4/MD-2 receptor complex 3929 929 7099 114609 4615 PMC3462935__F5 Schematic diagram depicting the potential interactions between EGF, S100A11, and Ca2+signaling pathway in human endometrial cell 1956 6282 3600 3976 PMC3471161__F1 VEGF pathway and the site of action of the inhibitors 7422 7423 7424 PMC3471675__F6 Structural Insights into the Common Gamma-Chain Family of Cytokines and Receptors from the Interleukin-7 Pathway 3560 3718 3716 PMC3474103__F22 Diagram demonstrating the sites and mechanism of action of novel agents for the management of pancreatic endocrine neoplasm 1956 5894 2475 PMC3477504__F3 Cytokinesis Mechanics and Mechanosensing 113220 3619 10788 8826 PMC3481450__F6 Overlapping network between MCF-7 and ZR-75.1 cells 7018 155382 7073 56943 11243 9836 PMC3484412__F2 Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway 2056 3717 2475 PMC3514012__F5 IPA generates IL-17C interactome 4792 4791 3656 3934 3002 4790 56300 2920 10758 1437 6347 3458 9235 3659 51561 27189 PMC3515033__F3 Classification of nucleotide-binding oligomerization domain proteins (Nods) 64127 10392 7124 3553 PMC3520613__F5 Macrophage VLDL Receptor Promotes PAFAH Secretion in Mother’s Milk and Suppresses Systemic Inflammation in Nursing Neonates 7436 1601 7941 PMC3525110__F3 Proposed model for EA signaling 4598 1325 5879 PMC3541122__F6 MiR-29 family is involved in multiple cellular processes 3717 6772 1021 8320 PMC3541634__F1 Schematic of TGFB1 signaling pathway and its regulation 57154 4088 4092 4087 4089 PMC3544113__F1 Main deregulated signaling pathways in PMBCL 7124 6778 9020 8651 3717 PMC3547332__F5 MicroRNA involvement in the inflammation, innate immunity, and oxidative stress pathways in AD and cancer 3075 7189 3654 3656 PMC3554558__F1 Putative role of VHL-HIF-EPO pathway in RCC progression 7428 2056 2057 PMC3559784__F5 The Carcinogenic Liver Fluke, Clonorchis sinensis: New Assembly, Reannotation and Analysis of the Genome and Characterization of Tissue Transcriptomes 5901 1311 8722 PMC3562715__F2 Oncogenic pathways in ABC-DLBCLThe stimulation of several surface receptors, including the B-cell receptor (BCR), CD40 or Toll-like receptors, triggers signaling cascades resulting in the activation of the NF-kB pathway 958 973 974 84433 4615 3662 604 PMC3566151__F1 TGFB and TGFB/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts 920 4087 4088 4089 PMC3576161__F1 Folate metabolic pathway 2346 4524 4552 4548 1312 PMC3583082__F3 This diagram summarizes the signaling pathway in thyroid carcinomas 673 5728 2475 1499 PMC3589701__F3 The epidermal growth factor receptor (EGFR) signaling pathway and molecules that may affect drug resistance 3082 2064 1956 2065 2066 6774 2475 PMC3596735__F5 Mechanism of response to anti-EGFR inhibitors 1956 3845 673 PMC3610285__F2 Melanogenesis 1499 2932 2033 5579 1906 4286 5594 1910 1638 7306 PMC3615671__F2 Metabolic modulation of epigenetics in gliomas 1950 1956 8841 PMC3617338__F1 Multivalency and conditional regulation at the cell surface 4245 4247 4249 PMC3619006__F1 Proposed model for PDGF-D signaling pathway that controls the processes of EMT 80310 5159 2475 7852 PMC3642156__F1 Host immune response to viral infection (Interferon Signaling Pathways) 7189 8651 51284 3654 6773 7297 PMC3647962__F13 TNFA signaling pathways to IKK activation 8717 7054 23118 7186 PMC3652647__F7 Schematic model of probable pathway of refractoriness of interferonB signal 29110 10392 3661 PMC3654583__F1 The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis 57506 3659 3627 PMC3673040__F1 Leptin is generated in adipose tissue and transported via the bloodstream to the hypothalamus 181 4852 4160 627 5443 5122 PMC3675380__F1 Tumor necrosis factor receptor family molecules that possibly activate the PI3K-Akt pathway in T cells 7124 4049 7186 7185 7188 7187 939 970 PMC3676658__F1 Schematic diagram showing the main components of the TGFB signaling pathway 4089 4087 4088 4092 PMC3678733__F3 Visualization of curated components of pathways and inferred interacting proteins and small molecules 26524 1018 100379198 8428 PMC3710659__F9 The proposed signaling pathways for 8-iso-PGF2Alpha-mediated modulation of human platelet function 7175 387 6010 PMC3716523__F4 TGFB signaling pathway 4087 4092 4089 7018 PMC3722362__F3 Regulation of Iron Absorption in Hemoglobinopathies 9518 3077 148738 7036 567 4089 2056 1050 6774 57817 PMC374303__F8 The multiple mechanisms by which HSV-1 blocks cellular IFN-based defense systems 83939 3717 6772 5371 6672 PMC3757382__F1 Modified Fearson and Volgenstein Model 4089 7157 324 3845 673 PMC3758882__F1 Normal complement activation cascade and its regulation 718 717 100293534 727 730 729 735 7448 PMC3764486__F2 Expanding roles for CD4+ T cells in immunity to viruses 920 29851 958 970 939 7054 PMC3772106__F1 How are STAT1 and cholesterol metabolism associated in antiviral responses? 6772 9023 7098 PMC3775430__F5 Model for possible sequence of genomic events in PCA progression 5728 2078 7113 PMC3776053__F7 A model for mid-day contrast sensitivity regulation 4862 406 9575 107 PMC3777916__F2 Using Biological Pathway Data with Paxtools 367 7157 54331 2782 PMC3782218__F1 Role of the proteins and mediators involved in iron homeostasis and impact of hereditary hemochromatosis protein mutations in chronic kidney disease 3077 654 7036 148738 6774 2056 3570 57817 PMC3784533__F1 Emerging concepts in immunity to hepatitis C virus infection 3454 3949 975 3716 7297 8651 9021 9076 7187 7098 29110 3661 3665 3627 57506 PMC3811055__F2 mTOR pathway 324 942 941 940 3558 2475 PMC3825194__F4 TGFB signaling pathway inhibitors under development for potential cancer therapy 4087 4088 4089 7018 PMC3831322__F5 Scheme illustrating potential mechanisms by which nandrolone reduces bone loss after SCI 89780 4041 7855 860 8507 PMC3832913__F3 Alternative pathway 3426 3075 7056 729 1431 966 735 PMC3839643__F1 Mammalian target of rapamycin (mTOR) -centric view of nutrient sensing for the induction of forkhead box P3 (FOXP3) 940 9021 6774 2475 50943 4088 PMC3845553__F1 IGF-1R as an anti-cancer target—trials and tribulations 3479 3481 3482 3480 5728 2475 PMC3861374__F4 Mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) 3082 3480 1956 5728 PMC3865928__F1 Citrobacter Infection and Wnt signaling 2932 324 1499 PMC3887194__F13 Schematic modeling of the TcpB inhibition of TLR4 signaling 7099 4118 4615 PMC3894232__F3 JAK2-STAT5B pathway and osteoblast differentiation 2690 3717 860 PMC3902845__F2 Multiple changes in gene expression influence KRAS activity, the KRAS downstream pathway and cell growth occur during development of a “mature” PDAC cell 1956 7039 1950 PMC3914023__F3 A model of the EZH2 functional switch from a polycomb repressor to a transcriptional activator in castration-resistant prostate cancer 23512 2146 8726 6418 367 5978 PMC3917750__F1 Dual regulatory effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on neuronal apoptosis 255738 23621 581 PMC3936506__F3 Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response 581 595 6741 PMC3936891__F1 Overview of the folate-methionine metabolic pathway investigated in this study 4397 4552 875 4524 PMC3942836__F1 Schematic review 6469 6608 7852 3845 PMC3949135__F1 Schematic Ig synthesis pathway 324 5091 10563 PMC3952039__F1 To Bud or not to Bud: The RET perspective in CAKUT 5979 2668 6714 PMC3958036__F9 Schematic model of how SH2B1B enhances gene expression and neuronal differentiation through STAT3 (step 1) 2246 2260 6774 25970 1958 1000 PMC3961644__F8 Proposed model for the negative or positive regulation of chondrocyte maturation or apoptosis by Smpd3/nSMase2, respectively 650 1280 6662 3037 1300 860 176 55512 PMC3967109__F2 Target gene set within Alzheimer’s disease environmental network 5309 4326 83464 10972 55798 PMC3968382__F1 New anti-complement drugs: not so far away 718 727 966 PMC3983565__F4 MAPK signalling cooperates with loss of APC to promote adenoma development 1956 1499 324 2932 90427 595 PMC3999169__F1 Roles for TNF-Receptor Associated Factor 3 (TRAF3) in Lymphocyte Functions 958 7186 7187 PMC4001054__F1 Proposed schematic models for the role of different lncRNAs (green) in neural development 1746 1745 4762 6469 4204 1750 1749 PMC4026703__F1 Schematic diagram showing the central role of the BMP6-HJV-SMAD signaling pathway in hepcidin regulation and the proposed interaction with other hepcidin regulators 654 57045 148738 164656 3077 9518 7036 4090 4086 1950 3082 2475 PMC4029299__F3 Gene- and pathway-based connectivity map of vismodegib and Gorlin syndrome 6608 8643 51684 PMC4030106__F1 Roles of IL-21 and IRF4 in immune and metabolic regulation 50615 6774 3662 2308 50943 PMC4033425__F3 Cell-cell coupling in the somitogenesis clock 3955 3458 6476 PMC4058194__F8 RTK/RAS/PI(3)K signaling pathway 1956 2891 5728 PMC4071223__F7 Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis 7097 7096 57154 4615 4118 387 PMC4078227__F2 Hedgehog signal pathway 6469 6608 51684 2737 2736 PMC4084561__F2 Regulation of type I interferon responses 3455 3454 3716 7297 6772 6773 6774 25942 3659 4283 4599 PMC4086337__F1 NLRP3 inflammasome regulates the caspase-1 dependent maturation and secretion of pro-inflammatory cytokines 7099 114548 3553 PMC4089598__F2 Regulatory T cells and co-stimulatory pathways 940 1493 324 PMC4100983__F4 Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer 3480 1956 2475 PMC4101637__F10 Working hypothesis on the distinct mechanisms by which TNFA/IL-1B and IL-6 inhibit the hepatic GH-IGF-I pathway during inflammation 2690 3553 3717 PMC4107162__F1 Mechanisms of cellular invasion by intracellular parasites 718 1378 3916 PMC4121055__F1 Beyond NPM-ALK driven lymphomagenesis: alternative drivers in Anaplastic Large Cell Lymphoma 238 6774 4838 7157 8626 639 619537 3662 4851 PMC4121847__F6 Diagram illustrating the proposed pathway by which TLR4/caspase-8/inflammasome up-regulation induces the processing of IL-1B and promotes the inflammatory response in acute glaucoma 114548 22861 3603 PMC4127586__F2 A model of Src homology 2B1 regulation of leptin signaling 3667 3717 25970 6774 PMC4129529__F1 Cell-proliferative signaling pathways in lung cancer cell 1956 2064 2065 2066 PMC4130202__F2 New molecules targeting angiogenesis and crosstalks between angiogenesis and tumor microenvironment 7422 7423 5281 PMC4130595__F3 Identifying a Polymorphic ‘Switch’ That Influences miRNAs' Regulation of a Myasthenia Gravis Risk Pathway 3480 3479 596 3845 PMC4136471__F2 Cellular and molecular interactions between HCL cells and their microenvironment 958 613 695 6850 7852 960 6387 9242 PMC4148035__F6 A negative feedback role of miR-326 in the Shh signaling pathway 6469 6608 2736 PMC4155893__F3 Positive feedback loop between EGFR and ERA36.Notes: A positive feedback loop has been confirmed that EGFR signaling activates transcription of ERA36 through an AP-1-binding site in the promoter region of ERA36 6714 1956 595 PMC4158461__F7 The underlying mechanism of CFE on the TLR4 signaling pathway 7099 4615 3603 3553 PMC4162005__F1 Model for regulation of expression/activity of multiple P450s by AKR1D1 1593 9420 80270 1582 PMC4174596__F1 Hh pathway response in vertebrates 6608 55733 64840 PMC4177461__F2 Helicobacter pylori mediated downregulation of B7-H2 on gastric epithelial cell inhibits Th17 cell development and facilitates bacterial persistence 2475 29851 920 PMC4177877__F3 Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis 920 961 140885 PMC4191659__F2 Receptor “hijacking” by malignant glioma cells: a tactic for tumor progression 6714 596 1956 6774 1950 3576 PMC4197584__F7 Pathway interactions regulating midgut patterning 4838 64321 8928 PMC4202123__F3 Structural basis for cancer treatment decisions 3082 2064 2065 1956 2475 PMC420359__F8 RA regulation of reciprocal interactions between the visceral endoderm and mesoderm that control endothelial cell growth and vascular remodeling 7422 4090 3549 PMC4206829__F4 Recent advances in understanding colitis-associated tumorigenesis 7099 6774 1499 PMC4215617__F3 MAPKs in the DAMP perception in innate immune cells 7097 7099 4615 7018 56675 PMC4220515__F1 Excess glucose and fatty-acid exposure linked to reduction of AMPK and consequent inflammation and fibrosis 51094 26060 4089 PMC4222698__F1 Clinical utility of pharmacogenomics in the management of hepatitis C 23586 57506 7297 3661 3716 101180976 6773 3665 10379 339855 9021 3455 PMC4232733__F1 The IGF1R/mTOR signaling pathway resulting in growth and survival of the cell 3479 3481 3480 5728 2475 PMC4237616__F2 Survival tree analysis of significant SNPs associated with NSCLC survival identified from the single SNP analysis (q<0.10) in our initial cohort 11197 80319 8313 81029 PMC4239617__F10 Proposed mechanism/model for the rationale of treatment with a combination regimen of GCs and IFNA in HBV-infected cell 2638 6772 4143 PMC4253516__F7 Transforming growth factorB (TGFB) and the canonical Smad pathway negatively regulate CD1d-mediated antigen presentation 4087 4088 4089 PMC4258562__F1 Schematic presentation of the pathways involved in the inflammatory response during acute pancreatitis 3383 3603 7099 4615 PMC4266525__F1 Pathway for corticosteroid synthesis in the human adrenal gland 6770 1583 3284 1584 1585 3291 3290 PMC4270131__F10 C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NFKB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells 1956 27035 124056 10811 PMC4278318__F1 NMI and EMT 3716 6772 9111 PMC4282639__F6 Chronic exposure to TGFB1 regulates myeloid cell inflammatory response in an IRF7-dependent manner 7040 7042 3665 7046 2919 2920 PMC4284611__F7 A model of enhanced cancer invasiveness and proliferation elicited by adjacent fibroblasts 6372 1499 23554 PMC4287622__F4 Protein Interactome of Muscle Invasive Bladder Cancer 1026 1029 7157 1019 3265 5894 595 3725 7057 1956 1281 1301 2335 PMC4306233__F2 Roles of F-box proteins in cancer 26271 4609 1499 64798 55294 3725 6502 993 4170 PMC4317318__F2 Immunologic synapse 50943 940 26191 324 PMC4338588__F1 Hypothetical model illustrating the molecular basis of insulin-induced metabolic stress in patients with poorly controlled T2D in which both blood glucose and FFA levels are persistently elevated 948 7038 8291 PMC4358097__F11 Plasma treatment abolish siRNA-induced knockdown of NRF2 3727 9817 3162 3725 1728 571 1437 PMC4364059__F3 The inflammasome pathway 58484 114548 22900 3603 PMC4367606__F2 Tumor cell ligands recognized by human GD T cells 3652 5819 4155 4151 335 324 4277 100507436 80329 79465 3383 PMC4369651__F1 Methotrexate pathway 6573 2356 8836 7298 3704 471 1719 PMC4382528__F2 Metabolic pathway of rotigotine 1557 1543 1576 54600 7366 1565 PMC4395781__F6 Representation of the proposed mechanism of action for CM-hfMSCs on insulin-like growth factor (IGF)-expressing cells 3485 3486 3480 3667 595 PMC4400874__F3 Initiation and perpetuation of NLRP3 inflammasome activation and assembly 51393 7226 846 222545 114548 PMC4404594__F1 Model of CIP2A involvement in the EGFR-RAS signaling pathways 1956 3845 2113 57650 PMC4405894__F3 Pathway of all possible EGFR family dimer combinations showing various growth factors known to activate EGFR family and all possible dimer combinations 7039 1950 6714 6774 2475 1956 2064 2066 2065 PMC4422175__F1 Bile acid biosynthetic pathways 1593 10858 9420 51302 80270 1582 6718 1109 PMC4424773__F2 Proposed signaling pathway for fat taste 948 29850 6786 PMC4428041__F3 Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease 219333 83737 57646 474 PMC4429755__F1 Regulation of miRNA biogenesis as an integrated component of growth factor signaling 29102 54487 2548 PMC4441360__F6 EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma 7039 1956 2065 PMC4447220__F6 Conceptual model of the effects of 15-LOX-1 on the PPARD–IL-6/STAT3 signaling pathway in relation to colorectal tumorigenesis 4582 4854 6774 PMC4468438__F1 Major pathways for the metabolism of IFO 1576 1577 1555 1559 1557 PMC4480315__F1 Homocysteine metabolism 4397 4524 875 PMC4487446__F7 Scheme illustrating the signaling pathway involved in the production of chemokines and cytokines induced by prostaglandin F2A (PGF2A) 3569 6347 3576 3553 PMC4494932__F6 Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells 174 5728 6714 7852 2475 PMC4499842__F7 UCB-MSC therapy is curative for IC bladder 3481 1950 8823 PMC4506691__F2 Pathways of steroid hormone synthesis in 21-hydroxylase deficiency, including backdoor pathway and 11-oxygenated androgens 1586 1528 3284 6715 8630 1646 8644 3293 PMC4511319__F4 Signaling network of endothelin axis (ET) and micro ribonucleic acid (miRNA)-200, the ET axis can be influenced by miRNA-200c on different pathways (red arrows: induction of pathway; black arrows: blockade of pathway) 4088 4087 9839 6935 PMC4515436__F12 Short range signalling between germline stem cell and its niche 145258 5979 2668 2674 1435 PMC4530367__F1 Alternative pathway of the complement system.The activation of the alternative pathway of the complement system depends on spontaneous hydrolysis of complement factor 3 (C3) in plasma leading to the formation of C3(H2O) 2271 718 729 730 735 PMC4534527__F1 Illustration of sonic hedgehog (SHH) signaling pathway 6608 51684 2736 2737 6469 2735 5727 595 4613 PMC4546458__F7 CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms 58191 10663 387 PMC4548049__F2 Inborn errors underlying herpes simplex encephalitis: From TLR3 to IRF3 7098 7187 115004 29110 3661 PMC4557273__F5 Sperm navigation along helical paths in 3D chemoattractant landscapes 2638 4397 100187761 PMC4563120__F5 The acute phase response is not generally up regulated in patients with < 14 mo survival 7124 8717 7186 6774 51295 2475 8739 2353 3725 1356 2243 2266 57817 7018 PMC4600616__F1 Sonic Hedgehog in SCLC 6608 6469 2922 2925 6010 PMC4612627__F3 Simplified model of a cell signaling process highlighting the flow from signals generated externally by epidermal growth factor (EGF) to the activation or repression of transcription 1950 1956 5728 2002 4609 PMC4619526__F1 Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study 1717 120227 1591 1594 7421 6256 PMC4622404__F2 N-Glycan biosynthetic pathways in induced pluripotent stem cells (iPSCs), iPSC-derived cardiomyocytes, and human cardiomyocytes 6487 6480 114475 8081 450086 100188795 4248 PMC4640466__F1 Canonical Wnt signaling.Notes: (A) Wnt off 4041 4040 2932 324 1499 PMC4640466__F3 Wnt inhibitors currently in clinical trials 4041 4040 324 2932 1499 PMC4653686__F10 Proposed model of the pro-apoptotic pathway GAPDH/Siah1 in high glucose-induced human retinal pericyte apoptosis 4841 2597 6477 PMC4661858__F3 Inhibitors developed against EZH2 2146 121536 8726 6418 PMC4678629__F2 Classical pathways of type I IFN induction and HCV mediating IFN resistance 7297 7098 57506 6772 6773 3661 PMC4682714__F2 Provides a schematic and abbreviated overview of the TGFB signaling pathway with indication of aneurismal diseases linked to it 7939 4087 4088 4089 PMC4684904__F3 Integrated, multi-cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses 952 51191 55008 64135 3959 2537 81030 64108 64761 4599 3665 9636 55601 5610 1026 79132 PMC4697282__F1 Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine 64840 79971 4038 1499 324 PMC4697282__F2 Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine 8658 64840 79971 PMC4702573__F6 Simplified model for CCC DNA synthesis and innate immune induction by HBV in AML12HBV10 cells 115004 29110 3661 PMC4713620__F2 Model of RNF43-regulated p53 cell cycling pathway 54894 4193 595 PMC4718713__F4 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications 2146 5971 5970 6714 367 PMC4718713__F5 Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications 7124 2932 324 1499 648 PMC4730276__F2 EGFR function in hepatocytes and Kupffer cells during hepatocellular carcinoma (HCC) formation 1956 4615 6868 3569 3570 619501 PMC4732882__F1 Metabolism and the circadian clock converge 9575 23411 406 10135 PMC4767650__F2 INHIBITOR OF APOPTOSIS PROTEINS AS INTRACELLULAR SIGNALING INTERMEDIATES 581 637 331 PMC4768650__F4 Interleukin-5 plays a fundamental role in the proliferation, maturation in the bone marrow, recruitment and activation at sites of allergic inflammation of eosinophils 3568 4067 4155 8288 PMC4792035__F1 Emerging functions of amphiregulin in orchestrating immunity, inflammation and tissue repair 374 1950 685 7039 1839 1956 PMC4801113__F2 Iron homeostasis in host defence and inflammation 164656 148738 654 659 7036 3077 3716 4089 57817 6774 PMC4806601__F1 Genetic variants in the MicroRNA biosynthetic pathway Gemin3 and Gemin4 are associated with a risk of cancer: a meta-analysis 192670 26523 27161 192669 PMC4810272__F6 3Cpro from different picornaviruses suppress the immune response 57506 7098 7187 7189 7297 29110 3716 3665 3661 3836 23118 PMC4810618__F7 Selective upregulation of Mcl-1 and HSP27 during HCMV infection of monocytes 1956 6714 2475 PMC4812578__F1 PI3K/AKT signaling pathway 10461 5728 7248 6009 4193 595 7157 PMC4837237__F7 A simplified overview of the ectodysplasin/EDA‐receptor/nuclear factor kappa B (EDA/EDAR/NF‐KB) pathway 1896 10913 128178 PMC4853920__F3 Alternative pathway is constitutively active at low levels through the hydrolysis of the thioester in C3 to C3(H2O) 718 2271 727 729 PMC4859092__F1 Workflow of the PSF-SOM method as applied to lung diseases 260431 85451 3240 PMC4859092__F8 Community detection in the lung disease graph 8213 3240 100188011 260431 PMC4864964__F2 How tumor-intrinsic Beta-catenin signaling mediates exclusion of T cells from the tumor microenvironment 6351 467 1499 941 PMC4867368__F12 Comparison of the lipoate assembly pathways of E 3989 3988 340654 PMC4874655__F3 COLORECTAL CANCER 324 4893 3845 4089 7157 673 2064 2065 4041 5728 7048 11211 1499 PMC4887618__F5 The working model of STAT3 and AvrA interaction in chronic intestinal Salmonella infected in colon cancer 3569 6774 1499 595 4316 PMC4894499__F3 Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury 1576 6822 570 54658 PMC4899229__F1 Type III IFN signaling pathway 6773 6772 6774 54106 51284 3661 PMC4922058__F4 Illustration of metabolic pathways reported to have altered gene and metabolite expression by integrated pathway analysis (MetaboAnalyst) 4199 3945 217 54947 3931 1119 56895 PMC4934079__F6 Model for how autophagy regulates Notch1 signaling pathway in biliary differentiation of hepatic progenitor cells 2475 6774 4851 PMC4935448__F4 Proposed model of miRNA regulation by simvastation and possible protective role of ubiquinol 596 993 19 8647 3654 27250 51809 7189 PMC4939711__F2 Catabolic pathways support metabolism during nutrient stress 55902 3845 1431 673 PMC4948960__F6 Pathway analysis of network signaling of some of the identified proteins as represented in the ingenuity pathway analysis database 4222 10608 51806 1844 10902 7461 83463 4335 3501 4781 7538 861 1432 949 1050 PMC4958958__F1 PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy 4522 1719 7298 4548 7172 27232 11252 4524 100188776 4552 PMC4959673__F6 HRPII recognition by human brain endothelial cells and the intracellular pathway that leads to BBB leakage 3553 4615 834 3383 7412 PMC4968117__F1 Epidermal growth factor receptor and its downstream signaling pathway 1950 1956 5728 2475 PMC4977324__F4 Influence diagram of is a naive Bayes model that contains minimal prior biological knowledge 22943 51339 51176 4609 595 27123 27121 168002 147906 6422 6424 960 PMC4978108__F2 Apoptosis in pancreatic Beta-islet cells in Type 2 diabetes 355 572 637 PMC4982242__F2 Activated canonical Wnt signaling pathway and the drug targeted components 22943 6424 4040 4041 64840 PMC4983539__F1 Innate Immune Evasion Strategies of DNA and RNA viruses 7706 57506 7187 29110 3661 3665 PMC4986142__F1 Resistance to RAF inhibitors 2885 4763 673 5728 PMC4988306__F2 Role of innate immunity in nonalcoholic fatty liver disease progression 54106 7099 7097 4615 114548 3603 PMC4999106__F2 Main components of innate immune system in epidermis and their role in atopic dermatitis (AD) 5132 10392 22861 PMC5006924__F7 IL-10-producing B cells induced by TRAPs 920 7097 4615 100187907 PMC5009385__F7 Insulin-like growth factor 1 regulates growth of endometrial carcinoma through PI3k signaling pathway 3479 3481 3480 3482 595 PMC5036360__F9 CXCL3-induced signaling pathway in adipocytes 3579 2921 2167 PMC5039077__F23 Overview of the GO-induced cytokine response and autophagy mediated by the TLR4/TLR9 signaling pathway 7099 54106 4615 7189 3661 PMC5053521__F6 Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier 1839 1956 56848 PMC5058735__F9 Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation 4610 4609 4613 7161 PMC5081350__F3 Wnt/Beta-catenin signaling therapeutic targets 2932 8658 607 PMC5105878__F1 Schematic overview of the stepwise mechanisms involved in the development of immunoglobulin E (IgE)-mediated food allergy 64806 85480 90865 PMC5109738__F5 Proposed novel caspase-1 working models 114548 7933 79629 100653365 PMC5114727__F1 Enzymatic steps of the P 79717 60490 5471 PMC5135597__F1 Intracellular cholesterol landscape: dynamic integrator of the immune response 9218 5007 10410 9023 3949 PMC5136496__F1 Apoptotic pathways 637 581 317 PMC5147022__F1 MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis 26523 192670 27161 192669 29102 54487 5901 23405 PMC5192300__F2 The cellular trafficking of CD1 molecules 912 911 909 PMC5214937__F2 Proposed T 51311 54106 7098 57506 4615 PMC5215107__F3 Genetic and Developmental Basis of Cardiovascular Malformations 7040 7042 7043 650 652 4087 4088 4090 4086 4089 10716 PMC5217522__F2 Possible explanation for opposing Notch-1 effects on NSCLC cells.Notes: Overexpression of constitutively active proteins is susceptible to experimental artifacts, the extent of which can be greatly modulated by environmental conditions 3479 3480 3481 PMC5218767__F1 Defective Treg cell suppressive mechanisms in IPEX and IPEX-like disorders 987 940 324 50943 1493 941 942 PMC5220041__F5 Thyroid cancer-related signaling pathway relational graph 673 2475 4318 PMC5222372__F1 Overproduction of Alpha-Lipoic Acid by Gene Manipulated Escherichia coli 347 3989 3988 PMC5226619__F3 Inflammasome: an emerging therapeutic oncotarget for cancer prevention 7124 6774 6772 PMC5253284__F2 The unique biochemical aspects of MET-mediated bypass signaling driven by cell surface RTK aggregates leading to de-coupling of EGFR oncogenic function from its tyrosine kinase activity (alternate signaling) 3082 1956 6774 5728 2475 PMC5280013__F8 miR-146a plays a critical role in limiting the inflammatory response to ischemia-reperfusion 7099 3654 7097 PMC5297991__F3 Functional analysis of the network containing validated segregating variants 7297 3716 3717 PMC5302945__F3 Seven protective miRNA signatures for prognosis of cervical cancer 2353 6935 5591 4602 2033 7422 472 7157 6662 5743 8289 23512 4609 2146 8726 4854 1788 344022 PMC5303891__F1 Development of a Reporter System for In Vivo Monitoring of Gamma-Secretase Activity in Drosophila 1950 3045 100187828 PMC5325772__F4 Summary of relationship between B-catenin, MEN1, and NCOR1 mutations and the Wnt signaling pathway that upregulates aerobic glycosylation 1499 9611 4221 PMC5325784__F2 HPV E6 and E7 interacts with core components of the interferon pathway 3454 3455 3717 3716 115004 6773 6772 10379 3665 3659 7187 7345 10010 3661 PMC533963__F11 Model illustrating the signaling pathway through which Brk participates in EGF-induced cell migration and invasion 1950 1956 1399 5879 PMC5343938__F1 Toll-like receptors (TLRs) and TLR-mediated signaling pathway 7097 7096 7100 10333 7099 7098 54106 51284 4615 114609 51135 3656 7189 7187 3661 3665 PMC5352107__F4 Triple-negative breast cancer: is there a treatment on the horizon? 1956 2475 2182 PMC5354887__F7 Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells 3845 3667 673 8315 PMC5357760__F2 Epidermal growth factor receptor (EGFR)–related signaling pathway in metastatic colorectal cancer 1956 5290 2475 PMC5362109__F2 Autoimmunity in vitiligo is driven by the IFN-Gamma-CXCL10 cytokine signaling pathway 3716 2833 4283 3627 PMC5384626__F1 Metabolic pathway of retinoic acid 157506 9249 216 8854 220 1592 56603 340665 PMC5390343__F6 Regulation of Fn expression in macrophages after S 929 6714 7189 2002 2335 4615 PMC5392045__F2 Interplay between autophagy, apoptosis, and the stimulator of interferon genes (STING) pathway 115004 29110 3661 PMC5395695__F1 Proposed mechanisms of pathogenesis in haploinsufficiency of A20 (HA20), otulipenia/otulin-related autoinflammatory syndrome (ORAS), and linear ubiquitin chain assembly complex (LUBAC) deficiencies 7124 8717 7186 8737 81858 90268 PMC5399110__F9 A schematic representation or summary of the alteration in endothelial cell signaling by aberrant NOSTRIN expression 115677 8717 7189 PMC5400657__F1 Long non-coding RNAs: a rising biotarget in colorectal cancer 283120 100033819 9775 1495 6935 960 9839 6934 10401 4609 255082 101805488 1385 596 2066 PMC5401738__F1 IL-12 activation of JAK-STAT pathway 7297 3717 6775 PMC5401756__F4 Adiponectin signaling via AdipoR1 and AdipoR2 activation 79602 5465 2475 9021 PMC5405508__F6 Network analysis of apoptotic genes modulated in response to V3000 and V3034 infections in spleen at 24 h pi 5980 3987 7903 1616 6304 4938 9821 7750 5520 6281 3306 6319 54331 6497 914 8805 9232 6366 3934 1638 10983 408 673 9935 3609 6275 3428 PMC5412458__F2 Ubiquitylating enzymes and deubiquitylating enzymes (DUBs) govern the outcome of TGFB signaling 4092 64750 9958 9618 7189 4091 PMC5412951__F1 Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action 2638 2932 1499 PMC5415104__F9 Anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways 7099 7100 4615 PMC5427079__F5 Enriched pathway analysis: The entities in the diagram colored purple are hits within positive gene list 4855 6814 6810 PMC5429551__F2 The dual role of TGFB in tumor progression and its association with RAC1b and RAC1 expression 5879 4087 4088 PMC5438623__F7 Screening effective differential expression genes for hepatic carcinoma with metastasis in the peripheral blood mononuclear cells by RNA-seq 3553 4318 3725 PMC5449515__F2 Mechanisms governing TGFB1–induced HASM contraction 4087 4088 4089 PMC5455318__F2 Hyperinsulinemia on the tumor cell microenvironment and intracellular signaling that contribute to tumor growth and progression 3481 3479 3480 3667 8660 PMC5481368__F1 Scheme tentatively summarizing the involvement of ACBD7 and its related product NDN in the effects of leptin in the ARC 4160 4852 181 5443 4692 414149 PMC5490213__F5 Representation of secondary metabolic pathway genes and tissue specific expression in response to MeJA and wounding in Bacopa monnieri 3156 790 3652 PMC5491785__F7 Schema of the putative mechanisms by which myostatin may influence the function of bone cells 22943 4772 4087 PMC5499671__F3 TGFB regulation of T cells in multiple sclerosis 7045 4087 4089 4088 100126333 4092 50943 PMC5504267__F2 Reactions involving ROS, antioxidant systems and energy metabolism 2937 2729 2730 847 920 2936 23530 7295 PMC5508315__F1 Mechanism of regulatory T cell (Treg) suppression 3586 324 942 941 940 PMC5508315__F2 Direct, indirect and semidirect pathway of allorecognition 324 920 960 PMC5536941__F3 APC-dependent role of CtBP in the Wnt/ Beta-catenin pathway 324 4040 4041 595 PMC5554756__F1 Negative regulators of the RIG-I-like receptor signaling pathway 7706 201292 9958 57506 29110 7189 7187 3661 PMC5559108__F3 Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics 5155 6356 7422 2243 8828 4254 4318 2919 2244 63827 4319 4353 7040 4804 4803 1950 4909 4908 PMC5559481__F1 LncRNAs serve as p53 regulators and effectors, participating in the p53 regulatory pathway 55384 100885779 378805 285194 PMC5559791__F6 Ingenuity Pathway Analysis of RNA-Seq data showed that the canonical coagulation system was over-represented by up-regulated genes in abdominal fat of LG cockerels 2161 9365 7035 5054 PMC5564228__F2 Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases 115004 3716 7297 29110 3661 6772 6773 10379 PMC5617345__F1 IGF-1R/AKT pathway determines cell fate in response to p53 5371 5763 3480 PMC5617549__F3 The molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer 1432 5209 3091 6515 PMC5644641__F1 Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway 1950 1956 2885 PMC5653517__F1 Resistance to BRAF inhibitors can occur through stromal extracellular signals (blue) leading to ERK reactivation upstream of MEK (orange) or to enhanced survival signaling(green) 4763 1956 2065 3480 673 4286 PMC5661256__F7 Schematic diagram of a signalling pathway related to anti‐apoptotic or anti‐inflammatory effects of polydatin on LTA‐induced injury 4049 842 836 PMC5666046__F2 Effect of mechanical strain on tenocyte 6347 5091 3553 729230 PMC5673628__F12 Schematic summary of baicalin-driven regulation of autophagy and inflammation during Mtb infection 2475 114548 3603 PMC5713423__F1 Schematic representation of Cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon genes(STING) signaling mediated T cell priming in tumor microenvironment 942 115004 941 PMC5715847__F1 B‐Catenin‐dependent pathway 1499 2932 324 PMC5726441__F4 PI3K pathway in human disease 7249 7248 6009 PMC5732032__F1 Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma 1956 5728 6714 2475 PMC5758348__F2 Illustration of the cellular and molecular targets of total and individual Panax notoginseng saponins (PNS) on neural cells destroyed by Alzheimer's disease 5966 5925 1103 PMC5759160__F3 Schematics of the Wnt/Beta-catenin signalling pathway 2932 1499 324 595 4040 4041 PMC5786332__F6 HIV replication in monocyte derived macrophages (MDM) by steroid hormones 3627 6373 3440 3456 3447 3454 4283 3551 3600 3593 6348 7124 3553 PMC5797063__F1 MicroRNA expression and activity in T-cell acute lymphoblastic leukemia 441478 4851 55294 407047 PMC5799812__F6 A convergent model for the pathogenesis of ANKL 3586 54790 7157 4609 PMC5803917__F3 TNF mediated anti-inflammatory effect of BM 2638 6401 6347 PMC5809773__F2 Biosynthesis of galactolipids in the chloroplast envelope membranes in Arabidopsis 759 51083 140805 PMC5810846__F3 Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics 4827 10692 367 PMC5811730__F4 Distinct mechanisms of small-molecule inhibitors and monoclonal antibodies for targeting receptor tyrosine kinases in cancer cells 1956 1950 1378 1380 2885 PMC5821903__F1 Schematic overview of anabolic and catabolic signaling in skeletal muscle 3479 3480 2690 4087 3717 367 2475 9499 PMC5823602__F4 UBASH3B promotes tamoxifen resistance and could be negatively regulated by ESR1 7157 2099 84959 PMC5824489__F3 Sirtuins in Antioxidant and Redox Signaling 3062 257194 23410 65985 22933 51548 9221 51547 6913 23411 PMC5826678__F2 Three basic mechanisms of aberrant activation of Hedgehog signaling 6608 5727 2735 PMC5840486__F1 Schematic illustration of the main hedgehog (Hh) pathway components 51684 2735 2737 2736 6469 5727 333929 6608 PMC5852411__F2 NHERF1 pathways 1956 1499 619410 PMC5853807__F5 Proposed model of immunopathogenesis of Borreliella burgdorferi during early cutaneous infection 50943 968 3586 7096 7097 10288 3665 11025 3620 8564 8942 4283 3627 6373 920 6279 6280 4599 3717 3437 91543 PMC5857537__F2 Molecular alterations in aldosterone-producing benign adrenal cortical neoplasms 3762 492 776 1585 PMC5859872__F1 Cell competition mechanisms 474168 23513 6092 5817 PMC5867104__F1 Wnt/B‐catenin signalling pathway 4040 4041 324 1499 2932 PMC5867859__F2 Wnt signalling in the adult Drosophila midgut during homeostasis, regeneration, ageing and hyperplasia 3067 8658 474168 324 1956 PMC5892644__F6 Cycloartobiloxanthone Induces Human Lung Cancer Cell Apoptosis via Mitochondria-dependent Apoptotic Pathway 596 4170 581 PMC5894800__F1 Enzymes and binding proteins involved in vitamin A and retinoic acid metabolism 4827 9227 1592 56603 PMC5899410__F3 TREM2 mediated innate immune regulation in Alzheimer’s disease 54209 1499 3553 7124 PMC5902007__F1 The gut microbiota in health and MS 4397 920 50943 PMC5927454__F15 Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill 1571 619501 6651 PMC5940270__F2 CGAS–cGAMP–STING pathway detects cytoplasmic DNA after DNA damage and activate type I IFNs and other cytokines 3661 29110 11277 115004 PMC5954603__F1 Involvement of exosomes in peritoneal dissemination 2335 960 3915 1956 PMC5968632__F2 Pathways significantly enriched for: (A) Loci associated with the vertical cup-disc ratio, cup area and intraocular pressure (P-value <7.0 × 10-6 in the GWAS) 4854 22936 7057 5990 4188 4088 1857 PMC5992122__F1 Universal Pathway for the Biosynthesis of Coenzyme A and Associated DiseasesIn green are indicated genes encoding either cytosolic or mitochondrial isoforms 79717 60490 5471 PMC5998975__F8 Proposed crosstalk pathway between A2AR signaling and Semas 10507 2064 387 10371 PMC6003554__F2 Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population 545 472 11200 PMC6009094__F1 Wnt signalling pathway.Left: the Wnt pathway is activated by the interaction between LRP5/6, Wnt and Frizzled 324 2932 4040 4041 PMC6027421__F2 Steroid biosynthetic pathway 1589 1588 1586 1583 PMC6031408__F8 Schematic describing the proposed role of MYC and CDKN1A in Wnt/Beta-catenin (CTNNB1) and angiopoietin pathway-dependent hyaloid vessel regression 7477 4040 4041 1499 1026 PMC6033382__F2 Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients 11219 11277 4615 3554 PMC6046285__F1 Major signaling pathways activated through IGF-1R and EGF-R in adrenocortical carcinoma 3481 1950 3479 3480 1956 3482 2475 PMC6046465__F8 The “cross-talk” between purinergic receptors during the uridine triphosphate (UTP)-mediated control of Leishmania amazonensis infection 24145 4050 834 PMC6061130__F3 Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process 665 139341 23786 65018 55669 9927 PMC6071982__F5 Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny 2618 4548 191 1491 2938 2937 2936 26873 4482 PMC6074871__F1 Synopsis of intratumoral cholesterol metabolism 6721 3949 255738 3156 6713 949 19 1586 6646 PMC6079124__F1 Several Proposed important schematic signaling pathways for Gankyrin in tumorigenesis 1499 3654 3553 387 5970 5728 3717 6774 PMC6085989__F1 Proposed model of host signaling cascade in response to microbial signals to promote hematopoiesis 7099 3716 7297 1611 10392 6772 6773 7187 10379 3661 4615 PMC6087481__F2 Influenza HA-induced degradation of IFNAR1 blocks the IFNAR signaling pathway 3454 3716 6773 6772 7297 10379 PMC6089851__F2 Major downstream targets of ERK1/2 in the MAPK pathway 2885 2534 6714 2353 3725 4609 PMC6108937__F3 Androgen receptor signaling R promotes diverse metabolic processes 367 2194 31 47 PMC6111853__F2 Proposed working model for the role of Rho GTPases in S1P‐induced GEnC activation in the presence of MPO‐ANCA‐positive IgG 1903 9294 53637 8698 1901 5879 387 3383 PMC6113440__F3 Modified chlorambucil (Chb‐M') as a safe lead compound of novel anticancer drug therapy 865 860 861 864 PMC6114229__F1 Schematic presentation of MAPK/Ras signaling pathway 1950 1956 2885 PMC6126176__F6 miRNA-core gene-risk signaling pathway regulation network 9863 2246 10000 7082 4205 221037 317 51719 627 2149 1027 PMC6126464__F2 The IL-6 receptor signaling pathway that is regulated by TRAF2 and TRAF5 7186 7188 6774 PMC6136406__F8 Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1–nuclear factorKB/p65 pathway in RAW264.7 macrophages and in COPD mice 23411 3553 260431 PMC6136429__F3 CIN activates cGAS-STING signaling 1436 7186 7187 115004 5970 29110 3661 5971 847 PMC6140703__F8 A schematic model of GC development 5347 572 595 PMC6147049__F3 ER signaling pathway 595 3091 3569 PMC6161739__F5 Current model of NLRP3 subcellular localization during its activation process.Notes: Primed NLRP3 is both cytosolic and associated with endoplasmic reticulum (eR) 114548 57787 9927 57506 79792 PMC6166692__F2 Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes 3458 4615 3717 6772 387082 3716 PMC6167486__F1 Proposed roles for CXCR3 and its ligands in melanoma 2833 4283 3627 6373 324 PMC6167501__F5 Canonical and non-canonical NFKB signaling pathways 958 4055 7186 7188 5966 5971 PMC6167501__F7 TGFB signaling pathway in melanoma 7042 7040 387 7043 PMC6167501__F8 Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy 28514 54567 10683 182 3714 4855 4853 4851 4854 5045 100188776 PMC6171574__F3 Signal transduction initiated by transforming growth factorB1 (TGFB1) 4015 649 4088 PMC6173469__F1 Genomic mechanisms of immune evasion in colorectal cancer: from discovery to clinical practice 567 324 1499 PMC6177401__F2 Innate immune response to DENV infection 51284 4615 115004 7189 7187 57506 29110 3661 3665 29102 PMC6177401__F4 Dengue virus and the host innate immune response 7098 51284 115004 4615 7189 7187 57506 29110 3661 3665 29102 PMC6179164__F6 Mechanisms by which IFNA disrupts thyrocytes to trigger AITDs 3627 6737 7038 PMC6192708__F2 Biomedical Informatics on the Cloud: A Treasure Hunt for Advancing Cardiovascular Medicine 3487 3479 351 653509 PMC6196292__F4 The proposed mechanisms of NEAT1 action in cancer 6774 1956 283131 2146 693198 PMC6196654__F1 Network of the two sets of top genes with P-value < 0.01 in the case–control and family-based analyses focusing on rare, deleterious variants 57539 2660 7289 112752 1131 3626 57728 2022 9742 8875 2785 9919 2885 2202 23193 5073 79875 4855 4088 3623 PMC6199368__F5 Hypothetical model to sensitize GC 4170 572 637 7507 7508 PMC6233116__F7 Tbx5 is required for a mesoderm–endoderm bidirectional signaling loop for cardiopulmonary development 7472 6910 7482 6469 PMC6248440__F2 Schematic representation of miRNA (left) and piRNA (right) biogenesis 29102 54487 5901 PMC6250919__F1 Genetic polymorphisms more consistently associated with non-alcoholic fatty liver disease and their suggested physiopathological role 80339 79143 53345 2646 PMC6256059__F1 Notch receptor maturation, ligand dependent and independent activation pathway and targetable steps 5045 102 6868 PMC6256271__F5 Targets of BA, JA, and BJ in the CD27 signaling pathway in lymphocytes 939 637 317 PMC6258792__F4 CREB1 signaling is predicted to be altered by ID 1051 1958 7832 1959 627 1961 1385 23237 2353 5743 5173 3726 3164 688 PMC6275407__F2 T helper cell differentiation signaling pathway 149233 940 942 941 50943 6775 643 29851 3570 50615 958 7039 6774 PMC6290143__F2 Role of the APC tumor suppressor gene in signaling expression of genes regulating the polyamine pathway 2191 4609 324 PMC6298633__F13 Schematic illustrating the potential contributions of ADAM9 (a disintegrin and metalloproteinase domain-9) to various chronic obstructive pulmonary disease phenotypes 8754 1956 6348 4317 PMC6302542__F3 Leptin regulates fatty acid oxidation in muscle by activating AMPK 5443 181 4852 4160 PMC6313617__F1 Metabolism pathway of capecitabine and 5-fluorouracil (5-FU) 4524 1719 4397 PMC6321423__F3 Schematic depiction of the TGFB signaling pathway 7046 4089 4087 4088 6774 PMC6325760__F1 Schematic diagram showing PR/RANKL pathway and downstream RANK-mediated signaling in mammary epithelial cells 1950 3398 7186 1956 595 PMC6328535__F6 Dacarbazine and PLX4032 cross-resistance emerges via distinct MAPK-dependent and -independent pathway activation 4893 673 2475 5156 PMC6328873__F1 State of art of neutrophil extracellular traps in protozoan and helminthic infections 759 7099 7226 51135 4353 PMC6331187__F8 The mechanism of celastrol in TGFB/Smad signaling pathway 7048 7046 4087 4088 4089 PMC6345051__F5 Visual representation of molecular interactions in the TSF flock 22795 4811 5549 55214 4192 1284 7373 1282 7045 64843 1634 58157 84894 2888 1293 54097 91653 51310 220323 25849 55024 7005 1674 23336 23705 55544 221662 PMC6358298__F3 PTEN- and IPMK-mediated nuclear phosphoinositide signaling through SF-1 253430 5728 3630 PMC6365663__F2 Overview of the heme biosynthetic pathway 81894 51312 54977 PMC6370283__F1 Exogenous pathway of lipid metabolism.apo B-48 = apolipoprotein B-48, apo C-II = apolipoprotein C-II, TG = triglyceride, apo E = apolipoprotein E, LPL = lipoprotein lipase 7038 348 4023 PMC6383596__F2 Effector cytokines can stimulate transcription of proinflammatory signals through the Janus kinase–signal transducers and activators of transcription (JAK-STAT) signalling pathway 3717 3716 3718 7297 PMC6405412__F12 Role of AKR1C2 and AKR1C4 in male virilization 6770 1583 3284 1646 1109 1586 3293 8630 PMC6406952__F2 LncRNAs are mediators of angiogenesis and inflammation in EC 732253 55000 64002 6774 7422 PMC6421413__F8 Protein associations and potential functions of SHARPIN in human megakaryocytes and platelets 81858 958 90268 9825 1540 5970 PMC6423797__F4 Regulation of Acetyl-CoA production by Beta-oxidation of fatty acids in mitochondria and peroxisomes, and the interexchange of 2-oxodipate and 2-oxogluterate by SLC25A21 over the membrane of these organelles in cells 85007 100129794 1962 3030 5352 PMC6425966__F3 Examples of prediction by eQTL signal convergence across distinct chromosomes 9103 3757 10089 958 PMC6431727__F5 RANKL-RANK signaling pathway via Btk in osteoclast differentiationTec family kinases are activated by RANK and bind to scaffolding proteins (BLNK or SLP76) activated by ITAM signaling, thereby forming a complex that cooperates to activate PLCG2 6850 7006 100124696 695 29760 5336 4772 PMC6433576__F1 Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression 324 3190 100270680 378938 23642 101805488 643911 220930 PMC6445151__F4 The differential network for the pathway “InlA-mediated entry of Listeria monocytogenes into host cells” in neuroblastoma tumors between HR and non-HR patients 6233 79872 1500 7316 6714 7314 7311 PMC6456508__F8 TLR4/NFKB pathway mediating miR-625-5p and COL1A1 in IDD pathogenesis 114609 695 4615 1277 3553 3569 7099 PMC6470053__F8 Nature and nurture: Confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments 3009 3024 149041 3007 PMC6471306__F1 Type I and III interferon production following pathogen sensing 163702 3454 3455 6773 3661 3665 10379 6772 PMC6477898__F4 Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease 9619 7454 757 1374 PMC6493882__F2 Two potential grounds for attenuation of IFN‐B bioactivity by statins 7124 3458 6772 3565 3586 PMC6498879__F6 Comfrey’s mode of action by interference with the NFKB signaling pathway 4615 3654 51135 7189 5763 PMC6502913__F7 USP7 functions in several canonical signaling pathways 7874 1499 4851 PMC6510893__F5 The Conserved Response of chickens to NDV infection 4599 6772 8651 3665 3659 PMC6517835__F9 Foxi3 inhibits epithelial differentiation and promotes suprabasal cell formation 344167 6425 4853 PMC6518732__F1 STAT3 signaling pathway in cancer cells 1950 1956 6714 11122 6774 PMC6524515__F1 ADAM17/TACE: a key molecule in brain injury regeneration 6868 1956 7039 PMC6538961__F7 A Model for cFLIPs-Dependent Lethal Ileitis(A) The complex IIb spontaneously forms in IECs overexpressing cFLIPs 8737 11035 197259 3603 6364 50506 3553 PMC6541219__F1 Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement 5741 5144 7227 9759 7018 PMC6553645__F3 Roles of mTOR complexes in the kidney: implications for renal disease and transplantation 5091 324 942 7412 PMC6556055__F10 Schematic diagram of mechanism on this research 9817 3553 1728 4094 PMC6559886__F5 Fistein Suppresses Human Osteosarcoma U-2 OS Cell Migration and Invasion via Affecting FAK, uPA and NF-ĸB Signaling Pathway In Vitro 1956 2885 1499 387 PMC6571700__F8 Signaling pathways modulated by EV miRNAs associated with T2DM 7049 90 3643 8660 4851 4853 8651 10644 10642 8850 4088 4092 2308 PMC6589846__F1 Schematic illustration of the interleukin (IL)-12/IL-23 pathway 3569 6774 6775 149233 3717 7297 3594 3595 PMC6590595__F1 WNT signaling model 324 2932 1499 PMC6606851__F8 Pathway activity measured with luciferase reporters for canonical signaling (STF) 7474 4920 2932 324 1499 89780 PMC6610018__F3 Interplay between the cGAS-cGAMP-STING pathway with mTORC1 signaling 11277 3661 29110 PMC6614345__F3 Differentially expressed miRNAs in thyroid cancer tissues modulating the TGFB pathway 7040 7046 4087 4089 4088 PMC6618585__F2 Tumorigenic mechanisms of Fusobacterium nucleatum in colorectal cancer 201633 7099 4615 330 1878 PMC6636046__F7 Enriched KEGG pathways generated by ClueGO and Cluepedia 10109 57153 23446 941 6385 3133 11214 7414 115004 1956 1499 6041 5468 64399 374 4853 4893 868 54331 2775 2562 284161 2778 81579 27436 PMC6657611__F2 Notch-targeting therapeutic approaches in TNBCs 4855 4853 4851 4854 50863 PMC6667284__F1 Intracellular interactions and fates of microbes opsonized with C3 in the extracellular milieu 718 55054 57506 PMC6681176__F1 Immunometabolism in atherosclerosis 3553 114548 7124 3458 PMC6690620__F1 Biochemical pathway of the creation of homocysteine and specific enzymes/vitamins necessary for conversion to methionine vs 4397 4524 875 PMC6703710__F10 Simplified model illustrating PDGFRA functions in elastogenesis 1950 7039 685 PMC6707130__F1 Developmental Alcohol and Circadian Clock Function 627 551 7432 9575 PMC6711563__F2 In an adult cell, Hh pathway is always silent or poorly activated 6469 6608 5727 51684 PMC6721829__F2 Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies 5728 595 6774 2475 PMC6721829__F3 Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies 3717 1499 6774 406947 595 596 5728 406915 100302237 PMC6736652__F1 Predictive biomarkers for bevacizumab efficacy in breast cancer 7422 185 4318 4313 4597 PMC6738809__F6 Mechanisms involved in vitamin D-mediated immunomodulation of neutrophils 7097 3566 1594 4118 4615 7421 9021 7189 PMC6754303__F2 Pathogenesis and Clinical Features of the Acute Hepatic Porphyrias (AHPs) 3162 211 2235 3145 PMC6768428__F1 The STING signaling pathway 81030 115004 51428 29110 3661 PMC6803036__F2 Secreted IgM: New Tricks for an Old Molecule 5091 718 2638 613 10113 8178 PMC6814203__F2 STING pathway activation initiates the anti-tumor immune response 55509 4283 3627 PMC6814613__F8 Proposed signaling pathway of the study 5156 1956 4815 PMC6827038__F5 Effect of Ad-Cyp8b1 on liver and intestine gene expression and mTORC1 signaling in HFD-fed mice 1582 26291 2264 9965 PMC6829200__F1 Components and regulatory factors in the complement alternative pathway (CAP) 718 1431 3075 3426 PMC6834480__F2 NKG2D/NKG2DL interaction activates NK cells 2885 6850 7535 PMC6834480__F5 Strategies for targeting the NKG2D/NKG2DL axis for cancer immunotherapy 4323 4313 6868 102 545 472 PMC6850018__F1 Modeling therapy resistance via the EGFR signaling pathway 1956 10681 3845 5728 2475 4149 PMC6850914__F1 Signal transduction pathways initiated by IL‐29 3716 7297 6773 4772 10379 PMC6852217__F1 Genes encoding the enzymes involved in Vitamin D action and metabolic pathway 1591 120227 1593 1594 7421 PMC6857900__F3 The Links between FTO and Colon Cancer 79068 4852 6774 595 PMC6872739__F7 Differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation 3553 1378 10461 9332 5879 PMC6876279__F1 The JAK-Stat signalling pathway 7173 2056 3458 PMC6880659__F5 Proposed model of TFC pyroptosis in excessive iodine-promoted HT 3553 114548 79792 PMC6880955__F1 Signaling pathways of RIG-I-like receptors (RLRs), cGAS, and AIM2-like receptors (ALRs) 115004 9447 57506 29110 3661 PMC6884345__F3 TGFB signaling in the colonic mucosa 4092 4087 4088 4089 PMC6885362__F4 Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells 324 3562 7039 7054 7124 978 PMC6885781__F4 Toxic function evaluation in cancer EVs 718 338 335 302 2243 2244 2266 3043 3240 5265 3263 7001 388697 3728 3698 83872 448834 PMC6889944__F7 Proposed antifibrotic mechanism of G 4087 4088 4089 PMC6895606__F1 CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases 79717 60490 80347 51102 11019 PMC6911338__F7 Schematic diagram of miR-155 intercellular transport and activation of mTOR signaling pathway 64798 2475 1977 PMC6913443__F2 Multifactorial regulation of hepcidin expression in hepatocytes 650 7099 3569 148738 7036 3077 6774 4090 4086 4089 PMC6917592__F1 Induction and subversion of the innate IFN response by HCMV 81030 115004 4615 54106 57506 29110 3661 3458 3716 3717 10379 9636 6774 3433 3437 3434 8519 10581 10410 PMC6923843__F5 Gene functional and Network pathway analysis of TRAP1, HSPD1, HSPB1, HSPA1L and HSPA1A 3329 10131 3305 3303 3315 PMC6927724__F8 MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice 5728 2475 55364 4280 PMC6933333__F7 LncRNA TNRC6C‐AS1 silencing inhibits proliferation and promotes apoptosis and autophagy of TC cells 9113 26524 6789 1786 1788 PMC6943877__F1 Pattern recognition receptors and inflammasome sensing mechanism during influenza A virus (IAV) infection 3553 7098 4615 114548 51284 57506 6772 6773 10379 PMC6944213__F6 Genotype, phenotype, and dose effects on Bcl6 inhibition upstream of the secreted factors canonical pathway 604 3458 3586 3592 PMC6953059__F1 Steps involved in the biogenesis and functions of miRNAs 54487 5901 6957 PMC6966677__F6 Cell proliferation and metastasis of gastric cancer by modulation of VGLL1 expression and activity 51442 7004 4318 1499 6925 51176 PMC6989403__F8 PMEPA1a promotion of tumor progression is mediated by Hippo signaling 9113 4734 56937 PMC6998390__F8 BACE2‐regulated pathway in glioma cells 4087 4088 25825 PMC7010219__F7 Role of DADS in leukemia cells 5879 6093 3984 PMC7012211__F6 Schematic diagram displaying the impact of AREG on intrinsic apoptosis signaling 374 1956 572 581 PMC7037240__F1 GM-CSF–IRF4–CCL17 pathway in inflammation and pain 7124 3662 6361 PMC7039088__F1 KEGG pathway map of the JAK-STAT signaling pathway obtained from the KEGG website 4170 8027 2670 2475 PMC7040395__F7 LGK974 on ccRCC 1499 64840 4040 4041 PMC7044323__F8 Gene expression profiles of p53 signaling pathway (hsa04115) in the bryostatin treated CD4+ T cells 56475 472 545 4609 92344 64065 3479 5728 7161 PMC7048131__F1 Classical IL-6/STAT3 signaling pathway in cancer cells 1950 1956 6774 PMC7051217__F3 Complement factor I deficiency 3426 718 629 PMC7058824__F1 Vitamin D Metabolic Pathway 1717 120227 2638 1594 PMC7068531__F2 JAK-STAT-3 signaling pathway 9021 595 6774 PMC7068849__F4 Regulation/function of IL-17 secreting cells during candidiasis 3553 64170 324 PMC7081367__F3 Disorders Caused by Genetic Mosaicism 5728 4763 2475 PMC7082927__F1 Molecular pathogenesis of thyroid cancer involves dysregulation of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/AKT pathways 673 5728 7015 7157 7849 5468 1499 PMC7105613__F1 Tryptophan catabolic pathway 169355 3620 8942 23498 23475 PMC7136349__F2 Targeting of the complement cascade in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis 727 730 729 735 PMC7136464__F1 IFN-I and IFN-II signaling 3454 3459 3460 3455 3716 7297 3717 6772 6773 10379 PMC7141597__F1 Division of labor between type I and type III IFNs in antiviral response 3659 3454 56832 3455 3717 7297 3716 PMC7143872__F1 Impact of physical activity on bone health 860 50964 3553 PMC7163052__F1 Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer 1958 3845 4803 2668 PMC7163250__F9 Our hypothetical model integrating AMP-activated protein kinase (AMPK), Hippo, and TBK1 signaling pathways during normal (A) and ZIKV-infected states (B) 115004 57506 9113 26524 29110 3661 PMC7164363__F7 EphB4, TNFR2 and ERK/MAPK signaling pathways 7187 7186 2002 PMC7169063__F2 IFN signaling pathway and different ways that the virus interferes with this pathway 7297 6773 10379 PMC7169117__F1 TGF‐B signaling pathway 7046 4087 4088 4089 7018 PMC7169117__F7 Schematic illustration of the major HTLV‐1 proteins and corresponding targets, by which HTLV‐1 modulates the TGF‐B signaling pathway 50943 4088 3050 PMC7188667__F4 Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression 7361 7366 7367 54490 PMC7196462__F2 Roles of SMAD3 in the TGF‐B and the BMP pathway 4088 4087 29102 4089 51592 7018 PMC7201932__F7 Graphical summaries 650 7040 4088 PMC7205985__F7 REGGamma-dependent regulation in ATC dedifferentiation 4092 4087 4088 4089 7849 PMC7219141__F6 Hypothetical signalling pathway showing that dysfunctional TGFB network signalling regulates tissue fibrosis and may play a role in this PCOS-specific insulin resistance and its limited response to exercise training 7939 3667 8660 4092 2475 1634 PMC7226287__F8 BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma 353500 9817 8805 PMC7226390__F7 Schematic abstract of the oncogenic and CSCs-promoting role of MALAT1 in HCC 378938 1499 6774 7291 PMC7226631__F6 miRNA networks generated using IPA (Ingenuity Pathway Analysis) for the altered plasma miRNAs in colorectal cancer 5053 5465 8434 100302141 693208 100302142 100422952 PMC7230684__F1 Folate metabolic pathway disrupted by methotrexate (MTX) 10599 1719 7298 4524 6573 PMC7238203__F1 DNA sensing mechanisms through the cGAS/STING/TBK1 signaling pathway 115004 79671 3661 29110 PMC7260582__F1 Action of cetuximab, encorafenib and binimetinib 3082 1950 1956 6774 2475 PMC7261019__F1 Rerouting of glucose utilization in RA and SLE T cells 5209 57546 2539 PMC7262792__F3 Possible mechanisms for growth hormone (GH) deficiency in children with mosaic gain-of-function mutations in the PI3K-AKT-MTOR pathway: 3480 2691 3486 3479 2475 PMC7285805__F2 Targeting the IL-4/IL-13/STAT6 signaling pathway for cancer therapy 3598 3597 7297 3716 3718 3717 494323 442891 6778 PMC7308735__F3 GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease 10457 4609 4318 1437 4322 8600 PMC7312067__F1 MITOL regulates both RIG-I-like receptor (RLR) pathway and Toll-like receptor (TLR) pathway; (B) Relativity between MITOL and cell death signaling in cancer cells 3654 4615 10010 57506 PMC7316593__F8 RSV induces Uric acid and leads to Th2 response 90865 6347 3553 85480 325 3596 PMC7316886__F3 Dysregulated IFN responses in COPD airway epithelial cells 3454 3455 7097 3716 7297 23411 10379 6772 6773 PMC7326927__F10 Summary of the effects of MPP+ and rotenone exposure on IL4-induced immune response on primary glial cell cultures 3565 131450 3566 4345 3091 5214 PMC7338517__F6 Spermidine activates RIP1 deubiquitination to inhibit TNF-Alpha-induced NFKB/p65 signaling pathway in osteoarthritis 3569 4314 4322 PMC7343503__F6 Resveratrol regulating MARCH1 expression 5728 6774 596 PMC7343963__F6 Construction of correlation network 154 2353 7538 1958 PMC7348140__F6 LncRNA NR2F1‐AS1 promoting breast cancer angiogenesis through IGF‐1/IGF‐1R/ERK pathway via sponging miRNA‐338‐3p 441094 3479 3480 PMC7353046__F6 Dowling Degos Diseases and Notch signaling 23509 56983 55851 3852 PMC7353046__F7 Adams–Oliver Syndrome and Notch signaling 54567 57514 285203 3516 57572 PMC7353687__F4 Signal pathways and metabolic pathways involved in abnormal RBP 90627 3231 3236 960 4609 5728 6774 PMC7358452__F8 The in vitro effects of the poly(I:C) ENCPs developed in this study 9332 941 7098 PMC7378891__F4 Canonical Type I IFN and non-canonical JAK1-and IFNAR2-independent IFNB signaling pathways 3716 3454 3455 7297 6773 6772 10379 7124 3429 PMC7388835__F5 Network diagram representing the regulatory effects with top consistency scores 8517 8767 1147 940 5054 6772 PMC7393270__F6 Ingenuity Pathway Analysis (IPA) top regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs 6927 3170 5008 3172 337 4583 2169 344 PMC7393270__F8 Ingenuity Pathway Analysis regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs 6773 6622 1777 7098 8517 9636 2634 79132 4940 4939 9101 91543 PMC7397827__F1 Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL) 7098 7124 8737 197259 PMC7401772__F6 Hypothetical scheme of the regulatory network underlying miR-19b targeted TSLP 85480 3565 3717 PMC7415793__F4 Treg in cardiomyocyte regeneration 6369 8530 10875 2621 4147 3481 374 8600 PMC7420839__F9 Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis 157506 220 56603 PMC7438278__F7 Working model for induction of cardiomyocyte necroptosis by Cops8 deficiency 11035 841 197259 8737 596 PMC7438479__F8 Pathway that Tisp40 regulates Ischemia-reperfusion induced pyroptosis in kidney 79792 3553 114548 PMC7442594__F7 Schematic proposed model of HDAC10 in KRAS-driven lung cancer development 83933 6662 960 PMC7456829__F4 Pathways of anti-TNF monoclonal antibodies action in Crohn's disease (CD) 2214 6868 355 7133 PMC7464161__F8 Possible mechanism of action of metformin and everolimus in QGP-1 and H727 cells 3479 3667 7248 7249 9049 2475 PMC7467481__F1 Balance between thrombosis and bleeding in liver disease 7035 11093 5340 PMC7471355__F3 Different roles of mTOR signaling in stress granules assembly 2475 64798 1977 PMC7471766__F3 Classic and trans-signaling IL-6R 6868 3716 6774 PMC7472175__F1 Schematic model for T-cell receptor signaling 27040 2885 10614 PMC7479667__F3 Indirect and metabolic effects of stress on T cells 941 942 940 2475 PMC7492550__F1 Identified mechanisms of molecular resistance to anti-TNF therapy in IBD patients 149233 5008 3575 929 PMC7493825__F3 NLRP6 inflammasome in health and disease 7096 4583 4615 171389 PMC7498644__F2 Activation of the canonical NLRP3 inflammasome 3553 3606 4615 114548 PMC7504460__F1 Mechanisms of obesity-induced development of endometrial cancer (EC) 51094 3480 3479 6462 3172 PMC7504502__F3 Feedback loop on BMP4 pathway mediated by miR-125a/b and miR-23a-24-27a during both the exit of mESCs from naïve state and their neuroectodermal differentiation 652 4086 4090 PMC7507458__F3 Links between lncRNAs and Hippo signalling cascade 6624 693217 3099 283120 112597 5209 400500 326343 647979 6286 PMC7528619__F1 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 57506 29110 3661 7098 7187 54106 4615 7097 4118 8836 7189 7874 7099 PMC7528619__F3 Race between Host Antiviral Innate Immunity and the Immune Evasion Strategies of Herpes Simplex Virus 1 3454 7297 10379 3455 27040 3437 9023 PMC7532048__F9 Mechanism diagram 10765 1499 6657 PMC7534081__F1 Simplified schematic representation of the synthesis and metabolism of vitamin D.7-dehydrocholesterol in the skin is converted to previtamin D3 by UV-B and then is thermally isomerized to vitamin D3 120227 1591 1594 PMC7543933__F2 IFN-Alpha-driven pDC-B cells crosstalk leading to antibody production in response to viral infection 5132 51284 4615 51135 3654 3663 3441 3553 958 PMC7551862__F7 FO promotes bone formation and growth by activating the IGF-1/IGF-1R signaling pathway 3479 3480 2932 860 PMC7552046__F6 Natural 5′ terminally deleted group-B enterovirus RNA forms can modulate type I interferon signaling pathway activation 3454 3455 1101 57506 3661 3665 PMC7556656__F1 NOTCH1 signaling pathway and effects of NOTCH1 mutations on CLL susceptibility to anti-CD20 mAb 4851 324 23013 102 PMC7559338__F6 Experimental verification of TFAP2C regulating EGFR in A549 cancer cells 1956 3845 5605 7022 PMC7565347__F4 Molecular interactions of ZIKV and DENV with the type-I IFN pathway 3454 3455 7297 3716 6772 6773 10379 9636 PMC7573295__F1 UCA1 can enhance expression of AKT1 and activate it through phosphorylation 3099 2475 6774 PMC7575565__F6 RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells 389 285671 6774 3082 PMC7576358__F9 Mechanism of forsythin protecting RPE cells from apoptosis induced by hydrogen peroxide through the Nrf2 signaling pathway 9817 1728 581 PMC7603112__F1 Vitamin D metabolic pathway by cytochrome P450 oxidases (CYPs) 120227 1593 1591 1594 PMC7607069__F9 TP53 signaling pathway via cBioPortal 1029 4193 4194 7157 PMC7612652__F8 Graphical summary 6714 1977 1956 PMC7648118__F2 Therapeutic strategies targeting the NMJ in dystrophic muscle 4593 2551 5913 7402 4038 PMC7654650__F2 Stem cells and lung regeneration 429 6003 3852 3856 56676 2299 1080 121643 2302 6774 3851 3860 7356 PMC7654982__F1 Hedgehog Pathway in Female Cancers 5727 6608 51684 PMC7654982__F2 Abnormal Hedgehog Signaling Pathway Leads to Female Cancers 3549 50846 6469 6608 5727 51684 PMC7654982__F3 Therapeutic Options to Block the Activation of Hedgehog Signaling Pathway 3549 50846 6469 5727 6608 51684 PMC7656422__F1 Immune suppression of Tregs via trans-endocytosis of CD80/86 from APCs 941 942 940 PMC7677403__F3 cGAS/STING- mediated signal transduction pathway 115004 29110 3661 3665 PMC7682655__F10 Diagram presentation of the molecular mechanism 55818 2113 9928 PMC7694028__F1a BRAF Mutation in Colorectal Cancers: From Prognostic Marker to Targetable Mutation 1950 1956 673 PMC7697807__F1 Activation and negative regulation of NFKB and STAT3 3569 6774 7124 PMC7716495__F2 Hallmarks of diverse categories of Wnt/Beta-catenin targeted agents in cancer 22943 4041 64840 PMC7750537__F1 Coagulation and clotting factor signaling 7035 5340 324 PMC7753939__F5 Top significantly related pathways of “herb-ingredient-target” networks in JZD against NAFLD: (a) nuclear receptor transcription pathway; (b) regulation of lipid metabolic process 5467 5465 3172 3717 2147 7099 3562 5468 6284 7298 7124 2263 PMC7754001__F7 Schematic diagram for the signalling pathways related to the EMT and airway remodelling in response to TGF‐B1 4087 4088 4089 7913 PMC7756074__F7 Proposed model of the non-genomic actions of 1,25 dihydroxyvitamin D3 (1,25 D) in the lungs infected with SARS-CoV-2 7124 7421 3716 7084 6772 6773 10379 4790 PMC7774640__F1 Cartoon proposed model of thyroid-associated ophthalmopathy (TAO) pathogenesis 958 3479 947 PMC7791181__F8 Working model of the target interaction axis after SCI After SCI, TGF‐B1 expression was increased, leading to phosphorylation of the Smad2/3 protein, thereby promoting miR‐21a‐5p upregulation 4092 4087 4088 PMC7805339__F1 Current understanding of the mechanism of action of luspatercept 100187907 9573 2662 10220 2657 60 4087 4088 PMC7813845__F4 BRD4 in regulating the STING1 pathway in antiviral immunity 115004 340061 29110 4790 3661 23476 PMC7813945__F4 JAs biosynthetic pathway and JAs signal transduction network 4015 26 30 PMC7822850__F8 LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway 102606463 84441 3516 100423038 6426 PMC7826455__F6 Role of miR‐362 in cervical cancer 6711 4088 4087 4089 PMC7827558__F1 Schema of the new arm of the DNA damage signaling pathway (DDR) 6432 6154 9425 604 23411 PMC7836472__F5 Network pharmacology perspective for deciphering potential mechanisms of action of Solanum nigrum L. in bladder cancer 1956 2064 5894 2475 4609 2002 595 3569 PMC7844244__F8 CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis 3002 50943 920 PMC7853880__F1 Canonical Wnt/beta‐catenin signaling pathway 4040 4041 2932 1499 324 3725 4609 PMC7859453__F2 MST activation center is the Hippo path 374 2069 1950 4771 PMC7865314__F4 Optimising radiation dose and delivery for optimal immunogenicity 324 11277 355 PMC7867516__F7 Related mechanism responsible for isoflurane-induced proliferation of squamous cervical cancer cells 2475 10013 5111 PMC7892499__F2 Strategies for antagonizing NLRP3 pathway myocarditis-related key inflammatory components 6280 6279 64127 114548 PMC7899295__F3 WNT pathway mutations underlie vitreoretinopathies that have phenotypic overlap with pathologies seen in the DC spectrum diseases 23554 4041 1499 55213 PMC7905058__F3 Gain-of-function of mutant p53 over proliferation, invasion and metastasis 153090 3190 29843 5879 PMC7918591__F4 Crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle pathway (CETCH pathway) 3045 100187828 23531 PMC7927147__F1 Development of opto-BMP system 659 4090 4086 4089 PMC7933481__F1 Anti-inflammatory effects of increased global SUMOylation in the intestine 114548 3605 6352 6356 6364 246778 4283 6387 3569 58191 50616 PMC7934455__AF1 lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/Beta-Catenin Pathway and Oncogenic Autophagy 8451 128439 1499 9140 PMC7937946__F2 NetworkAnalyst visualization of Reactome pathway “neutrophil degranulation” genes with elevated expression in individuals from Endotype A 4311 5580 6280 226 8826 10383 7879 7097 3310 5663 3304 7316 1991 54472 PMC7961974__F8 Pathway activation patterns of the NOTCH pathway in the different CD-groups 8650 23385 100506013 3955 1387 PMC7985079__F1 Modified model of the HMA-induced viral mimicry in leukemic cells 6041 6035 3665 10379 57506 PMC7985832__F2 TREX1 dysfunction triggers the cGAS-STING cytosolic DNA sensing pathway 11277 3661 115004 29110 PMC8002238__F1 Cyclophosphamide metabolic pathway (adapted from Jonge et al., 2005 ) 1555 1559 1557 1576 PMC8018731__F11 NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition 1431 4478 6714 27035 PMC8020338__F4 Ingenuity pathway analysis of the TREM1 signaling pathway in the DH82 cell line treated with B 54210 3717 3654 PMC8021541__F7 LncRNA H19 regulates sensitivity to EGFR‐targeted therapy through different mechanisms 1956 283120 6714 23576 PMC8021541__F2 LncRNAs sponge microRNAs and then regulate radiosensitivity through different signaling pathways 1956 5820 283104 158228 55796 5728 10498 283131 3206 4313 4318 1000 PMC8023146__F1 African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway 115004 8408 29110 3661 PMC8030716__F1 Entry of the virus leads to activation of the innate immune system which comprises of macrophages and dendritic cells 941 958 942 5132 324 4615 7124 PMC8043057__F1 Interactions of proteins encoded by studied genes in COVID-19 718 1431 2271 727 11093 7056 PMC8054829__F1 Type I interferon in the pathogenesis of systemic lupus erythematosus 4615 3663 3665 6775 PMC8073279__F1 Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women 1719 4524 875 PMC8080578__F4 New paradigm for the regulation of STAT2 protein in melanoma formation 6773 55294 2931 2932 PMC8086039__F1 Kill Two Birds with One Stone: Role of the RIPK-3 in Necroptosis and Inflammasome Activation 11035 197259 90550 114548 PMC8093869__F1 Neuroinflammation in HIV-Related Neuropathic Pain 2535 4920 1524 7474 7852 5091 836 PMC8110006__F3 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs 652995 100124700 7474 PMC8110006__F4 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs 6424 643911 100124700 7472 7473 11197 PMC8110006__F5 Toward Colorectal Cancer Biomarkers: The Role of Genetic Variation, Wnt Pathway, and Long Noncoding RNAs 11197 100124700 982 6424 643911 652995 PMC8123811__F3 On Iron Metabolism and Its Regulation 3077 7036 654 148738 4089 4090 4086 57817 PMC8124456__F1 CD26/DPP-4: Type 2 Diabetes Drug Target with Potential Influence on Cancer Biology 1803 6387 7852 2475 PMC8129370__F3 Value of miRNAs in the prognosis of obese patients receiving bariatric surgery 554212 6868 2309 PMC8134040__F7 EphA2–YES1–ANXA2 pathway in GC growth and progression 1969 7525 302 4609 6774 PMC8145847__F3 Hepatitis C Virus Uses Host Lipids to Its Own Advantage 3949 975 9076 100506658 PMC8150590__F1 Crosstalk between Interleukin-1B and Type I Interferons Signaling in Autoinflammatory Diseases 115004 114548 3553 PMC8166497__F5 N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis 4094 6955 8739 PMC8194090__F7 Molecular Mechanisms of Chondrocyte Proliferation and Differentiation 100188776 6662 860 PMC8197283__F2 WNT4 Balances Development vs Disease in Gynecologic Tissues and Women’s Health 650 2308 7044 10938 54361 2535 1499 3206 3484 5617 PMC8199487__F7 NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the Beta-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition 596 581 660 55869 4255 1499 595 PMC8205988__F1 Anti- or pro-tumorigenic function of adiponectin in colon cancer 51094 79602 2475 2919 PMC8220689__F6 Circular RNAs regulate cancer-related signaling pathways and serve as potential diagnostic biomarkers for human cancers 6955 693225 693185 PMC8227153__F4 Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients? 4615 7098 148022 3659 3665 6041 4940 3433 3434 3454 3455 9636 PMC8237569__F3 Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction 2245 23109 1719 PMC8254453__F6 Circulating mtDNA-mediated acute lung injury during sepsis due to STING-dependent autophagy dysfunction 115004 29110 7124 PMC8264993__F8 AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury 2621 558 19 PMC8265496__F4 Necrotizing lymphadenitis may be induced by overexpression of Toll-like receptor7 (TLR7) caused by reduced TLR9 transport in plasmacytoid dendritic cells (PDCs) 4615 51135 3654 7189 51284 5132 3665 54106 PMC8266896__F7 EGR1 and RXRA transcription factors link TGFB pathway and CCL2 expression in triple negative breast cancer cells 6347 1958 4088 6256 PMC8267412__F2 Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer 89780 2262 100422909 1499 PMC8268881__F4 Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights 2778 1045 3845 5728 54894 4089 1029 7157 PMC8289875__F2 Longitudinal genome-wide methylation study of PTSD treatment using prolonged exposure and hydrocortisone 627 5590 1387 51196 7054 22943 4041 2903 10763 8912 PMC8294037__F2 Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis 7038 3976 4193 2638 PMC8298276__F1 Drugging multiple same-allele driver mutations in cancer 2475 1950 2065 1956 PMC8303588__F1 TGFB Signaling: From Tissue Fibrosis to Tumor Microenvironment 4089 4088 4087 4092 PMC8305917__F3 The Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom 387 8826 5879 PMC8318284__F1 Network analysis of 12 miRNA-mRNA interaction pairs associated with OS in EOC patients 10544 10631 10135 2012 1839 467 3043 9023 PMC8326751__F4 Combination of a Novel Genetic Variant in CFB Gene and a Pathogenic Variant in COL4A5 Gene in a Sibling Renal Disease: A Case Report 716 715 718 727 PMC8339131__F8 TRAIP as a key prognostic DEG between CTCs and metastatic lesions in osteosarcoma 10293 23189 3486 PMC8345475__F1 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics 6469 6608 51684 PMC8375232__F5 Functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma 6935 7482 1499 619501 PMC8375987__F3 Three visualizations of part of the “PKC-gamma calcium signaling pathway in ataxia” at WikiPathways (wikipathways:WP4760) 773 7222 491 PMC8388390__F4 Effect of GP19 Peptide Hyperimmune Antiserum on Activated Macrophage during Ehrlichia canis Infection in Canine Macrophage-like Cells 90268 2323 3589 50616 5699 59067 1435 3447 7124 3458 2 3592 3596 3593 11009 3587 3565 3586 55801 3460 51561 3566 29949 50604 PMC8392882__F5 Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications 1950 2885 595 PMC8405670__F4 Comparative analysis of therapeutic effects between medium cut-off and high flux dialyzers using metabolomics and proteomics: exploratory, prospective study in hemodialysis 3827 5176 462 4060 2335 3026 1003 5627 3481 5950 1191 PMC8416891__F4 Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Stimulated by Mycobacterium tuberculosis PPE57 Identifies Characteristic Genes Associated With Type I Interferon Signaling 4790 7124 4792 9636 6773 7706 4600 3433 4939 4940 PMC8419469__F5 Analysis of Gene Expression Data Incorporating Tumor Purity Information 3910 3909 3675 6714 3918 10319 85301 3913 5747 50509 3914 1290 PMC8422731__F1 STAT3 pathway as a molecular target for resveratrol in breast cancer treatment 6774 1950 1956 PMC8422911__F10 cartoon illustrating the mechanisms by which deficiency of Adam15 leads to exaggerated COPD in mice 8751 2475 2833 260431 PMC84262__F1 IL-1 signaling pathway 4615 3656 7189 PMC8429462__F8 Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine 1644 3661 29110 PMC8430835__F1 Emerging Role of Non-coding RNAs in Drug Resistance of Ovarian Cancer 100302203 283120 693121 100126316 652995 388948 100124700 406928 378938 693207 PMC8431939__F3 CD112R/CD112 axis: a breakthrough in cancer immunotherapy 201633 10666 10225 PMC8441965__F7 Inhibin BA is an independent prognostic factor that promotes invasion via Hippo signaling in non-small cell lung cancer 122786 23286 3624 PMC8447269__F2 Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia 6608 2736 51684 PMC8452151__F4 Mechanisms that decode combinatorial and temporal codes of pathway activity to achieve stimulus-specific responses 3661 1052 467 3456 7124 PMC8453895__F3 Contribution of irisin pathway in protective effects of mandarin juice (Citrus reticulata Blanco) on metabolic syndrome in rats fed with high fat diet 5468 252995 7350 PMC8460989__F8 Exosomes Transport Anti-Human Immunodeficiency Virus Factors from Human Cervical Epithelial Cells to Macrophages 7098 4938 4600 9636 PMC8461988__F1 Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis 7097 4049 3845 929 7099 1956 5743 PMC8468752__F1 Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia 64240 348 9429 3156 4023 27329 255738 1071 PMC8469305__F5 Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NFKB Signaling Pathway 2194 7038 3553 PMC8482137__F4 Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups 11041 26229 1733 6799 1735 54579 54659 54657 10941 54600 574537 7365 133688 PMC8483971__F1 Ethnic Differences in Iron Status 7036 3077 148738 57817 650 654 PMC8486294__F7 CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion 3579 7216 6374 7431 PMC8492608__F12 Pathological Features of Tumors of the Nervous System in Hereditary Cancer Predisposition Syndromes: A Review 8650 7428 960 5426 6608 PMC8494658__F3 Where are we now? Emerging opportunities and challenges in the management of secondary hyperparathyroidism in patients with non-dialysis chronic kidney disease 5212 1593 1591 1594 PMC8495217__F3 Different View for an Old Disease: NEDDylation and Other Ubiquitin-Like Post-Translational Modifications in Chronic Lymphocytic Leukemia 4738 7124 7186 PMC8495591__F4 Blood glucose control contributes to protein stability of Ski-related novel protein N in a rat model of diabetes 4089 4087 4088 64750 PMC8514845__F2 Scaling the tips of the ALPS 6774 10401 9021 PMC8517268__F7 Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration 56339 57721 54915 PMC8522789__F1 Clinical and Mechanistic Characteristics of Current JAK Inhibitors in IBD 3558 59067 55364 3569 3567 7297 3717 3586 3716 100187761 PMC8532063__F1 Current Diagnosis and Management of Primary Chylomicronemia 338328 4023 64788 PMC8532163__F9 Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway 7099 3929 929 4615 PMC8533551__F1 Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis 659 650 2022 PMC8539850__F6 Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress 2638 4118 10096 PMC8549894__F2 Pathophysiology of Exercise-Induced Muscle Damage and Its Structural, Functional, Metabolic, and Clinical Consequences 23216 200576 5879 PMC8560861__F8 Model summarizing the pathway described in this study along with known effects of CCL20 and CXCL8 signaling in the context of cancer 6364 6774 3576 3577 PMC8564337__F6 Reduced MAGI3 level by HPV18E6 contributes to Wnt/B‐catenin signaling activation and cervical cancer progression 10763 260425 1499 PMC8578927__F1 Making a Killer: Selecting the Optimal Natural Killer Cells for Improved Immunotherapies 355 3458 6352 6375 PMC8581318__F10 SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/B‐catenin pathway 1499 324 595 PMC8584118__F3 Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections 64127 10392 91662 7098 51284 3606 3553 79671 3661 171389 1665 79792 114548 22861 58484 PMC8593085__F6 An In-Depth Review of Niraparib in Ovarian Cancer: Mechanism of Action, Clinical Efficacy and Future Directions 115004 3661 29110 6573 324 PMC8603983__F3 Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs 693219 84293 9817 55000 283120 128071539 PMC8613610__F2 Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease 120425 27293 5091 1431 9619 19 4363 124976 PMC8614623__F7 Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGFB1/Smad3 Signaling Pathway 4087 4088 4089 4092 PMC8615685__F3 Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson’s Disease 114548 7099 720 3553 PMC8616319__F3 Immune Components on Stem Cell and Dormancy in Cancer 6347 6352 22943 55246 4318 PMC8616345__F4 Advances in Immunotherapy and the TGFB Resistance Pathway in Metastatic Bladder Cancer 4092 64750 4089 4087 4088 7018 PMC8626172__F8 Network Pharmacology‐Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of Herba Sarcandrae 3569 5579 1364 1277 3315 1545 6347 5054 2920 891 3162 7412 3627 4609 6401 890 5733 5328 5743 1281 4318 3383 PMC8632002__F2 Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19 51284 4615 80231 121260 3663 3665 PMC8634673__F1 Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome 6364 7054 50943 3458 3119 325 920 PMC8637215__F7 Cytokine and Complement Response in the Glaucomatous BB1-CTGF Mouse Model 1675 629 718 727 3627 2919 2920 PMC8638980__F5 Association of air pollution and homocysteine with global DNA methylation: A population-based study from North India 7808 3553 3569 4397 PMC8647006__F1 Regulatory switches, reinforcement, and redundancy in DSB repair pathway choice 672 580 9025 165918 56916 PMC8657692__F9 Evaluating the Effect of Lenvatinib on Sorafenib-Resistant Hepatocellular Carcinoma Cells 1956 2264 2475 PMC8666273__F5 Runx3 regulates iron metabolism via modulation of BMP signalling 864 654 57817 PMC8666287__F6 Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling 23385 4851 23462 PMC8666469__F3 Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection 7297 6775 3717 6774 3716 6772 6773 1950 3569 50604 3586 29949 PMC8699356__F1 Interleukin (IL)-9 Supports the Tumor-Promoting Environment of Chronic Lymphocytic Leukemia 572 3667 3718 6772 6774 2885 PMC8702371__F3 Precision Nutrition Algorithm for Cancer 5290 5728 324 PMC8707654__F6 Metabolomic Profiling of Blood-Derived Microvesicles in Breast Cancer Patients 5091 3931 54947 PMC8712646__F1 Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention 4851 3558 4283 3627 2833 3716 3717 PMC8722197__F6 Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis 4602 5066 2077 PMC8740004__F6 FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma 8841 1499 3169 PMC8740962__F1 Proposed simplified schematic representation of SARS-CoV-2 induced intracellular pro-inflammatory signalling pathway 7189 114609 7099 7098 51311 51284 4615 PMC8750882__F12 Extracellular Vesicles Derived from Bone Marrow in an Early Stage of Ionizing Radiation Damage Are Able to Induce Bystander Responses in the Bone Marrow 4041 7480 7855 1499 6423 51701 25805 1488 PMC8751739__F8 Suppressive effects of dental pulp stem cells and its conditioned medium on development and migration of colorectal cancer cells through MAPKinase pathways 1499 596 581 355 PMC8752802__F1 IFNG signaling integrity in colorectal cancer immunity and immunotherapy 3459 3458 3716 3460 3717 4283 3627 PMC8753429__AF1 Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NFKB signaling pathway 4280 3146 7099 PMC8753429__F6 Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NFKB signaling pathway 4280 7099 3146 4615 PMC8761741__F2 Criminal of Adverse Pregnant Outcomes: A Perspective From Thyroid Hormone Disturbance Caused by SARS-CoV-2 7200 3553 7038 7054 PMC8763513__F10 3B,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy 10628 114548 2475 3603 PMC8771518__F7 Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis 114548 3553 79792 PMC8773516__F2 Pathophysiology and Therapeutics of Thoracic Aortic Aneurysm in Marfan Syndrome 7939 7048 7046 4089 4087 4088 PMC8773838__F2 Janus Kinase Signaling Pathway and Its Role in COVID-19 Inflammatory, Vascular, and Thrombotic Manifestations 3717 3716 3718 PMC8779539__F1 Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID 4397 875 4524 PMC8786701__F3 Impact of DNA testing on management of patients with colorectal cancer 1950 1956 2475 5728 PMC8788178__F2 Multiple roles of mothers against decapentaplegic homolog 4 in tumorigenesis, stem cells, drug resistance, and cancer therapy 4087 4088 4089 4092 4091 4090 4086 PMC8790423__F1 Statin as a therapeutic agent in gastroenterological cancer 3157 3156 3949 2194 PMC8793120__F1 BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma 7042 648 1499 PMC8803653__F2 Rituximab in the Treatment of Interstitial Lung Diseases Related to Anti-Melanoma Differentiation-Associated Gene 5 Dermatomyositis: A Systematic Review 6376 7852 920 PMC8812234__F6 IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer 1499 139285 960 PMC8819604__F3 Pathophysiological Pathway Leading to the Development of Valve Calcification in Chronic Kidney Disease 8074 5741 4018 255738 PMC8830041__F7 Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells 3455 7297 11274 8651 9021 3669 9636 7189 23765 84818 PMC8841513__F5 CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation 3091 57506 3661 7018 114548 PMC8844466__F6 In silico Analysis of SARS-CoV-2 ORF8-Binding Proteins Reveals the Involvement of ORF8 in Acquired-Immune and Innate-Immune Systems 7098 7187 3661 7054 PMC8849249__F2 Low Bone Mineral Density in Hemophiliacs 4040 4041 1499 PMC8861005__F7 Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway 7038 5111 596 3667 PMC8865963__F1 Human genetics of SARS-CoV-2 infection and critical COVID-19 57506 3661 29110 3665 7098 51284 4615 3454 7297 3716 3455 6772 6773 PMC8867675__F2 Integration of liquid biopsy and pharmacogenomics for precision therapy of EGFR mutant and resistant lung cancers 1956 2475 6774 3082 PMC8875960__F4 Druggable Molecular Pathways in Chronic Lymphocytic Leukemia 7186 5971 7187 9020 330 PMC8876671__F1 SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance 57167 1499 57761 6925 89780 648 8313 595 PMC8884367__F3 Inhibitory Immune Checkpoint Molecules and Exhaustion of T cells in COVID-19 3902 3932 2534 PMC8899158__F9 CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway 8727 9475 4586 3565 PMC8904974__F8 Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition 3265 4893 2885 PMC8906189__F4 The Coagulation Pathways Leading to the Formation of D-Dimer During Blood-Brain Barrier Disruption 324 920 2224 5340 PMC8909069__F3 Biomarkers in FLT3 AML 2885 619537 6776 2475 PMC8923098__F1 Reversing epigenetic repression of transposable elements for improving tumor immunogenicity 9869 26136 115004 57506 PMC8923803__F9 Identification of IL20RB as a Novel Prognostic and Therapeutic Biomarker in Clear Cell Renal Cell Carcinoma 2033 1956 50616 79923 50943 10401 3717 3587 282616 53833 5970 11009 282617 3718 3586 7124 3588 282618 3953 53832 163702 PMC8935233__F8 PROX1 promotes breast cancer invasion and metastasis through WNT/Beta-catenin pathway via interacting with hnRNPK 5629 3190 324 1499 7454 84133 2932 PMC8938628__SF1 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway 367 28 100187761 PMC8946740__F10 Proposed model of ARF-IFNB pathway 6772 6773 10379 3454 3455 604 2660 PMC8955684__F2 Angiopoietin-Like Protein 4 and Insulin-Like Growth Factor-1 Expression in Invasive Breast Carcinoma in Young Women 55364 3479 6774 3480 2475 596 572 PMC8964978__F1 IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment 6774 102 6868 PMC8976844__F6 Mechanism graph of the regulatory network and function of miR-30c 607 1499 960 PMC8979958__F3 Mammalian sirtuins and metabolic reprogramming 51548 51547 23410 23411 22933 23408 23409 2744 PMC8992556__F1 Intracrine androgen biosynthesis and drug resistance 1586 3283 3294 8644 3295 1646 2973 8630 PMC8995458__F5 Fibroblast growth factor 21 reverses high‐fat diet‐induced impairment of vascular function via the anti‐oxidative pathway in ApoE knockout mice 26291 348 4280 PMC8995768__F1 Bone Morphogenetic Proteins Shape Treg Cells 657 659 4091 94 7048 7046 93 92 91 3397 860 PMC8997162__F1 Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer 2260 5728 2261 2263 2264 1956 2064 2065 PMC9007691__F6 Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3-Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer 2012 5879 27035 PMC9017014__F1 Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy 89780 7474 4041 6934 860 PMC9023807__F2 MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer 407009 7046 693166 100616361 PMC9037156__F9 Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis 7124 1839 1956 PMC9052997__F1 An adult case of NOTCH3 mutation in pulmonary artery hypertension 4854 3516 100188776 PMC9066194__F4 Function and Regulation of SAPCD2 in Physiological and Oncogenic Processes 2146 3717 1499 PMC9069786__F11 Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway 3717 6774 114548 6659 3553 PMC9081983__F3 Non-Coding RNA in Neurological Complications Associated With Enterovirus 71 7187 7189 4615 51135 11213 3654 4703 PMC9092395__AF1 LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway 100506428 79039 2475 PMC9099719__F1 Tumour Stem Cells in Breast Cancer 100187761 1499 2475 PMC9100112__F9 Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression 3976 3977 283120 4088 6774 PMC9103444__F3 Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer 581 4170 283120 PMC9105159__F1 Wnt/Beta-catenin pathway modulation via DKK1 inhibition 4040 4041 324 2932 22943 1499 51176 PMC9107227__F7 Positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression 4790 3576 3579 3577 6772 PMC9117704__F5 Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms 3717 920 6774 PMC9121316__F1 Forward single‐cell sequencing into clinical application: Understanding of ageing and rejuvenation from clinical observation to single‐cell solution 9760 920 952 2475 PMC9139434__F1 Leveraging STING, Batf3 Dendritic Cells, CXCR3 Ligands, and Other Components Related to Innate Immunity to Induce A “Hot” Tumor Microenvironment That Is Responsive to Immunotherapy 3661 29110 115004 PMC9143066__F1 Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention 4524 4397 875 PMC9147761__F1 Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application 3569 4072 122953 79923 648 PMC9163066__F8 Schematic model for the circSCAF8-miR-140-3p/miR-335-LIF pathway 3976 3977 6774 PMC9166437__F1 TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target 348 54209 5336 PMC9168369__F1 Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies 169355 3620 3398 8942 8564 23475 PMC9170726__F8 Fas/FasL regulating mROS and IFNG production after IL-12/IL-18 stimulation 355 8011 6775 PMC9170969__F1 Antiviral immune response by African swine fever virus (ASFV) 57506 51444 79589 115004 3661 7099 7098 7297 3455 6773 10379 3458 3717 3460 PMC9185072__F3 Increased serum concentrations of estrogen-induced growth factors Midkine and FGF2 in NF1 patients with plexiform neurofibroma 2078 4763 2247 7018 PMC9203892__F3 TIGIT as a Promising Therapeutic Target in Autoimmune Diseases 324 201633 10666 941 940 PMC9213050__F7 TLR2-mediated NFKB signaling pathway is involved in PPV1-induced apoptosis in PK-15 cells 7097 4615 114609 51135 7189 PMC9221635__F3 Telomere Maintenance and the cGAS-STING Pathway in Cancer 29110 3661 115004 PMC9223893__F1 Gene Expression of the D-Series Resolvin Pathway Predicts Activation of Anti-Tumor Immunity and Clinical Outcomes in Head and Neck Cancer 22949 2854 2358 2841 PMC9259489__F3 Intestinal epithelial cell mitochondria serve as metabolic signaling platform translating microbiome-derived signals into mucosal responses 11315 120892 64127 55054 57506 114548 7189 51295 6566 6584 10105 345611 PMC9261067__F7 Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation 4313 4318 2305 1499 PMC9267148__F11 Prediction of CIAPIN1 (Cytokine-Induced Apoptosis Inhibitor 1) Signaling Pathway and Its Role in Cholangiocarcinoma Metastasis 7040 4088 6498 7046 6497 9372 PMC9268458__F1 Gene-Environment Interactions in Vitamin D Status and Sun Exposure: A Systematic Review with Recommendations for Future Research 1717 7421 2638 120227 PMC9268676__F2 Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms 3569 3586 3565 3596 PMC9273597__F1 STING cg16983159 methylation: a key factor for glioblastoma immunosuppression 115004 3661 3627 PMC9318662__F1 In Silico Approach in the Evaluation of Pro-Inflammatory Potential of Polycyclic Aromatic Hydrocarbons and Volatile Organic Compounds through Binding Affinity to the Human Toll-Like Receptor 4 929 7099 114609 4615 PMC9323014__F8 Runx2 in Microtubule Acetylation in Bone Metastatic Breast Cancer Cells 79969 860 10013 PMC9324059__F5 Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2 5972 3586 7422 2475 7157 1956 3667 PMC9339612__F2 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer 7046 101928099 6667 367 100996425 PMC9339612__F4 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer 100124700 367 4193 100750225 PMC9354605__F3 Landscape of chimeric antigen receptor T cell therapy in breast cancer: Perspectives and outlook 652070 29851 939 940 PMC9355054__F1 Systematic review: Molecular docking simulation of small molecules as anticancer non-small cell lung carcinoma drug candidates 5728 1950 1956 2885 PMC9359464__F3 Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host 943 5524 1647 5987 PMC9368912__F2 Epidemiology and Molecular Biology of HPV Variants in Cervical Cancer: The State of the Art in Mexico 100507316 5728 1499 595 8313 PMC9369061__F1 JAK/STAT Pathway and Its Selective Inhibition in the Treatment of Atopic Dermatitis: A Systematic Review 3716 50616 7297 6772 6774 3565 6778 3718 3596 3717 386653 85480 3567 PMC9372905__F1 Rare Variants in the Norrin-FZD4 Signaling Pathway and Familial Exudative Vitreoretinopathy (FEVR) With Extraocular Phenotypes 4693 8322 4041 23554 2932 324 1499 PMC9379395__F8 Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway 10397 574493 4092 1958 PMC9386726__F6 Ubiquitin-ligase TRAF6 and TGFB type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells 4087 4088 4089 7018 26060 7189 9212 4313 4318 PMC9405025__F3 Yeast Beta-Glucans as Fish Immunomodulators: A Review 60 337 6850 3553 4615 PMC9407997__F2 Genetic Variants Associated with Elevated Plasma Ceramides in Individuals with Metabolic Syndrome 6610 166929 259230 9517 55304 204219 29956 79603 91012 340485 56624 PMC9408851__F3 Function of N-Myc Downstream-Regulated Gene 2 (NDRG2) as a Negative Regulator in Tumor Cell Metastasis 6774 8651 6935 57447 4602 PMC9409103__F3 Recent Developments in the Understanding of Immunity, Pathogenesis and Management of COVID-19 115004 29110 3661 PMC9409897__F5 Enhancing Genome-Scale Model by Integrative Exometabolome and Transcriptome: Unveiling Carbon Assimilation towards Sphingolipid Biosynthetic Capability of Cordyceps militaris 729 727 7038 PMC9418004__F8 Mechanistic illustration showed PLAA-METTL3-TRPC3 axis in ovarian cancer 9373 56339 7222 PMC9433749__F1 Gearing up for battle: Harnessing adaptive T cell immunity against gram-negative pneumonia 2919 324 374 PMC9441790__F2 Primary cilium in kidney development, function and disease 1499 2253 54361 7849 7484 PMC9445673__F8 Gene network downstream plant stress response modulated by peroxisomal H2O2 3299 23640 810 11213 1409 PMC9448891__F6 Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells 5265 6772 6773 7098 3661 3665 7099 4615 51135 3654 3553 3569 3576 PMC9454891__F9 Apigetrin Promotes TNFAlpha-Induced Apoptosis, Necroptosis, G2/M Phase Cell Cycle Arrest, and ROS Generation through Inhibition of NFKB Pathway in Hep3B Liver Cancer Cells 581 8737 11035 197259 PMC9462646__F4 Phase separation in immune regulation and immune-related diseases 115004 11277 29110 3661 PMC9463134__F1 InterferonG receptor pathway: a new way to regulate CAR T cell-solid tumor cell adhesion 3458 3716 3717 3383 PMC9478028__F3 Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis B virus cure 9700 7015 898 890 619501 6418 1499 PMC9478117__F8 MiR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGFB signal pathway 54677 4089 4087 7048 7046 PMC9495000__F6 Transcriptome Analyses Provide Insights into the Auditory Function in Trachemys scripta elegans 81539 2566 200959 9568 3763 PMC9500586__F3 Personalized nutrition: A review of genotype-based nutritional supplementation 9249 216 8854 220 PMC9502082__F1 RIOK3 and Its Alternatively Spliced Isoform Have Disparate Roles in the Innate Immune Response to Rift Valley Fever Virus (MP12) Infection 29110 3661 57506 PMC9515729__F2 Beneficial Role of Vitamin D on Endothelial Progenitor Cells (EPCs) in Cardiovascular Diseases 3383 7412 3569 7421 PMC9519310__F7 Interaction of the IFNG/JAK/STAT1 and JAK/STAT3 Signalling Pathways in EGFR-Mutated Lung Adenocarcinoma Cells 6772 1956 1950 6774 PMC9526459__F2 Revisiting potential value of antitumor drugs in the treatment of COVID-19 51311 7098 695 51284 PMC9529349__F1 Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome 4615 834 114548 79792 7054 PMC9563138__F2 Metabolic Pathways in Breast Cancer Reprograming: An Insight to Non-Coding RNAs 6713 2194 47 3156 100302114 100423029 PMC9586150__F8 Identification of a miRSNP Regulatory Axis in Abdominal Aortic Aneurysm by a Network and Pathway-Based Integrative Analysis 2152 7046 7048 1432 PMC9586216__F1 Protein arginine methyltransferase 5 regulates SHH-subgroup medulloblastoma progression 51684 6469 6608 PMC9603448__F6 Engineered Human Intervertebral Disc Model Inducing Degenerative Microglial Proinflammation 6347 6352 3576 6348 3569 PMC140192__F7 Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF 4838 1956 4089 4087 PMC149906__F5 A model to explain the effects of varying Fgf8 dosage on cell survival 2253 2290 10252 2018 652 PMC151039__F1 The classical pathway for bile acid synthesis begins with CYP7A1, which converts cholesterol into 7Alpha-hydroxycholesterol 1581 9420 51302 PMC1526464__F8 Bile acid and cytokine inhibition of CYP7A1 gene transcription 3553 3172 1581 PMC1601945__F1 Model of RNF11 interactions in the TGFB receptor signaling pathway 64750 4092 4089 26994 PMC1800873__F1 Progression pathway network with w = 0.8, E = 0.8 and the LH algorithm 5328 1029 2719 PMC2193492__F1 Pathways initiating transcription from pIV of the CIITA gene 7391 6772 4261 PMC2235195__F1 RA synthesis pathway 1592 56603 6256 5914 5915 6257 340665 PMC2517789__F1 Cytokines and their receptors in cardiovascular diseases 3976 5008 1270 1271 3977 9180 PMC2533793__F10 Model for negative regulation of Wnt signaling pathway by corepressors SMRT and NCoR 1499 6925 8841 PMC2538513__F4 Schematic illustration of the involvement of c-Ski and TGFB signaling pathway in nurse cell formation 4087 4089 4088 6497 PMC2596750__F8 TNFR1 and LTBR ligation-induced signaling in vascular EC 7124 4055 6387 2920 PMC2613471__F1 Revisiting Notch in remyelination of multiple sclerosis lesions 4851 4099 2152 PMC2682514__F1 Nodes with the highest relative betweenness centrality (in orange) and their interacting partners (blue) in the pancreatic cancer pathway 2885 1956 7157 PMC2761115__F2 Gonad function and sexual differentiation 2018 56956 7490 7536 284654 6736 54361 6662 2254 268 50846 3625 10468 PMC2784308__F1 An illustration of the MC1R pigmentation pathway and the loci implicated in melanoma risk 434 4157 7306 PMC2838200__F3 Proposed scheme for how macrophage-based nanoparticle drug delivery could affect disease outcomes in neurodegenerative disorders 4803 2668 627 PMC2856263__F6 Signaling pathways activated by DMXAA 10392 64127 29110 3661 PMC2882734__F6 Pathways of VLC-PUFA biosynthesis 60481 54898 83401 64834 6785 PMC2891887__F2 Lymphangiogenesis and Lymphatic Metastasis in Breast Cancer 7424 7422 6366 1236 7852 PMC2915700__F6 Schematic representation of the line of events by which HA modulates the leukocyte-EC interaction 960 3037 3553 PMC2937585__F1 Folate metabolic pathway 4524 875 4397 1719 PMC3017081__F3 Crosstalk between interleukin signalling pathways 3569 3562 3567 3558 3565 3574 PMC3073335__F2 RNA helicases of the RIG-I-like receptor (RLR) family play a crucial role in the innate antiviral response 6773 10379 3665 3661 PMC3084393__F10 Proposed diagram for Alpha-mangostin-induced apoptosis in COLO 205 cells 355 90427 637 PMC3109859__F6 Finding Homes for Orphan Cytochrome P450s: CYP4V2 and CYP4F22 in Disease States 242 59344 126410 PMC3124359__F1 Estrogenic effects on gp130 signaling 3976 5008 3717 6774 627 PMC3140140__F1 Variation in the suppressive abilities of Wnt antagonists with respect to canonical and non-canonical Wnt signaling pathways 4040 4041 324 2932 PMC3152870__F4 Signalling pathway of type III interferons (IFNs) compared with type II and type I IFNs 3458 3459 3460 6772 10379 PMC3163259__F1 Wnt/Beta-catenin signalling in the absence and presence of Wnt stimulus 22943 27123 27121 144165 1499 2932 27122 51701 PMC3185539__F1 Summary of NSP1 inhibition of the innate immune response pathway 7098 3661 6772 6773 29110 PMC3185772__F2 Regulation of Blood-brain barrier permeability, entry of WNV in the brain and factors involved in the pathogenesis of WNV-induced neuroinvasisve disease 5340 2920 7098 6387 PMC3235041__F1 SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen 1576 1555 1559 1565 1557 1544 6817 PMC3248767__F2 Bevacizumab Treatment for Advanced Breast Cancer 3082 7039 1950 5155 PMC3256499__F2 VEGF pathway and site of action of the inhibitors 7422 7423 7424 PMC3316585__F1 Formal Modeling and Analysis of the MAL-Associated Biological Regulatory Network: Insight into Cerebral Malaria 695 4118 7097 7099 PMC3324360__F5 Simplified TGFB pathway 3397 25805 7046 4088 467 1649 PMC3341105__F2 Signal transducer and activator of transcription 3 (Stat3) signaling 6714 960 2475 PMC3347034__F3 Inhibition of type I IFN signaling by DENV: IFNA/B binds the type I IFN receptor (IFNAR), which is composed of IFNAR1 and IFNAR2 and is found on the surface of nucleated cells 3455 3454 7297 3716 10379 6773 6772 PMC3370249__F7 Proposed FasL-Met signaling pathway 7054 6774 595 PMC3374082__F7 Schematic representation of the data 5465 4854 3569 4397 348 PMC3478260__F4 signaling pathways triggered by L1CAM 3897 3611 6714 PMC3494605__F1 A role for vimentin in Crohn disease 55054 64127 4790 PMC3502106__F5 Feed-forward signaling in which FGF-9 controls Wnt-2a expression and mesenchymal Wnt/Beta-catenin signaling 2255 7477 652 1499 PMC3515033__F4 Neural and humoral activation of the brain by the periphery 1356 4922 6651 PMC3540819__F1 Main signaling pathways involved in thyroid carcinogenesis are the MAPK and PI3K-AKT pathway (reproduced with permission) 5728 673 2475 PMC3565104__F4 Proposed model for progesterone and retinoid action in endometrium and endometriosis 3294 1592 1382 64220 PMC3591623__F7 Model for the putative mechanism by which Fsk-cAMPi negatively regulates IL-2R signaling in human T-cells 3558 3716 3718 PMC3603502__F10 Redox regulation of signaling pathway leading to T-cell activation/proliferation 1236 27040 325 PMC3607680__F3 The one carbon cycle 4524 4397 875 PMC3613936__F2 Striking the target in iron overload disorders 148738 164656 654 PMC3641106__F8 Differential Use of TLR2 and TLR9 in the Regulation of Immune Responses during the Infection with Trypanosoma cruzi 2821 54106 7097 PMC3656432__F4 Myostatin (Mstn) pathway 2660 4088 4089 PMC3712714__F1 Interaction between the vitamin D endocrine system and the inflammatory signaling pathway in control of cancer cell growth (for details, see ) 1594 7421 1591 PMC3772119__F1 Drosophila JAK-STAT pathway in blood cell formation and immunity 27040 2548 604 PMC3792734__F1 Main biosynthetic pathway of saturated and monounsaturated fatty acids 2194 79071 6319 PMC3807757__F1 MyD-88 dependent TLR signaling pathway: MyD-88 (*) associates with the cytoplasmic domain of TLR, recruiting IRAK1 and IRAK4 to activate TRAF6 4615 114609 7097 7096 10333 3654 51135 54106 51284 7189 7099 PMC3824052__F2 Smoking-Induced CXCL14 Expression in the Human Airway Epithelium Links Chronic Obstructive Pulmonary Disease to Lung Cancer 56667 3728 9547 6768 PMC3829308__F1 Interferon beta signaling pathway 7297 3455 3454 PMC3831618__F2 Fe(II)-dependent, uridine-5′-monophosphate Alpha-ketoglutarate dioxygenases in the synthesis of 5′-modified nucleosides 3240 643414 643418 PMC3857355__F3 TGFB/Smad signal transduction pathway 4087 4088 4089 PMC3857355__F8 Therapeutic strategies that have been used to target the TGFB signaling pathway to reduce scarring 100187907 4087 4088 4089 PMC3888787__F1 Bile acid synthesis occurs by two pathways, the classic ‘neutral’ pathway and the alternative ‘acidic’ pathway 1593 1581 80270 6718 PMC3891682__F2 Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment 9423 5879 3983 1630 223117 3897 10505 2773 9037 5362 57556 56924 10298 80031 3985 1946 6093 1942 2045 1948 2050 5921 PMC3900785__F1 The metabolic pathway of homocysteine 4397 4524 875 PMC3928643__F4 IL-12 centred network analysis 3593 7040 3458 7099 3592 PMC3941025__F1 MAVS filaments and activation of the IFN-I pathway 57506 3661 3665 PMC3943304__F6 Canonical and non-canonical JAK-STAT pathway and its subversion by BCR-ABL or mutant KIT 3815 3717 9846 6714 6776 2475 595 PMC3951765__F1 NLRP3 inflammasome activation: CD36 serves double duty 948 7099 10333 7100 PMC3956136__F1 Canonical Wnt B catenin signaling pathway 4040 4041 2932 324 1499 PMC3967813__F2 IFNAlpha-2b signaling via JAK-STAT pathway, adapted from 3455 3716 7297 1399 PMC3991963__F1 TGFB2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma 10468 7042 4052 7057 652 4090 4086 649 4015 7052 4017 84695 84171 PMC4028364__F1 Conservation of host cells and pathogen categories in zebrafish and mammalian infection by eukaryotes 6778 3553 7124 3576 PMC4049967__F1 IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF) 3718 6774 3605 PMC4069315__F2 Immune responses induced by lactic acid bacteria 4049 7097 3603 PMC4081624__F1 IGF signaling pathway 6750 2691 2692 3482 2690 3483 3479 3481 3480 PMC4091806__F1 A New Lnc in Metastasis: Long Non-Coding RNA Mediates the Pro-metastatic Functions of TGFB 9839 6935 6774 PMC4105941__F1 The Self-Limiting Dynamics of TGFB Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation 4092 4087 4089 5494 64750 PMC4111689__F1 Targeting the Achilles’ heel of drug-resistant cancer stem cells 3845 1956 5899 PMC4159398__F2 Membrane receptors and intracellular signaling pathways activated by IL-4 and/or IL-13 3598 3716 3718 3717 6778 PMC4178743__F7 Interference in type I IFN production by HEV proteins 7706 57506 3661 PMC4187736__F11 Model recapitulating the role played by HUWE1 in regulating Shoc2-supported ERK1/2 activity 8036 1950 10075 PMC4202148__F6 Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma 7391 22801 3696 7410 8976 6093 PMC4213195__F5 Schematic model of Wnt- and SHH pathways working interdependently in GBM based upon observations in this study 6469 6608 2736 1452 1499 PMC4259002__F4 Epidermal growth factor receptor pathway 1956 2475 6774 PMC4287999__F4 Mechanism of T-helper-17 (Th17) cell-mediated lymphangiogenesis 3553 3606 7424 PMC4322943__F1 Phosphortlated Smad3 is stabilized by ERG in ERG-positive prostate cancer cells 4087 4088 4089 2078 PMC4346117__F3 Evolutionary model of non-spatial clustered metastatic ovarian cancer 9915 7157 51322 PMC4364715__F4 Novel Genetic Locus Implicated for HIV-1 Acquisition with Putative Regulatory Links to HIV Replication and Infectivity: A Genome-Wide Association Study 26267 596 22844 PMC4364943__F10 Proposed model for the integration of NFAT and NFKB signalling pathwaysSwollen AF conidia are taken up by macrophages 54106 4615 6850 695 PMC4428393__F2 Cytoplasmic folate-mediated one-carbon metabolism is required for de novo purine, thymidylate, and methionine synthesis 4522 4524 4397 PMC4467862__F3 Crosstalk between erythropoiesis and iron metabolism involving TGFB family member GDF11 4089 151176 10220 654 PMC4614816__F1 Cells express exosomes comprising lipids however lipids impact on cancer cells according to cell phenotype 4851 7852 5728 PMC4649479__F1 Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei 100379198 907 5091 PMC4672200__F3 Schematic of the proposed non-canonical Wnt signaling pathway induced in the ceca from experimental chickens with persistent colonization by Salmonella Enteritidis 7474 815 1499 PMC4676894__F5 Proposed model for the postulated functions of STAT1 in HR-DLBCL-NOS 3458 3569 3586 3716 3717 6772 PMC4711159__F2 Mechanisms regulating CD4+ and CD4+CD25+forkhead box protein 3 (FoxP3) balance 50943 920 3558 1493 940 958 941 942 324 PMC4727329__F7 MILP model identifies causal relationships from PI3K/AKT and TP53 pathways (KEGG) (a) PI3K/AKT pathway is altered in phase 1 of breast cancer progression; (b) TP53 pathway is altered in phase 2 of breast cancer progression 5290 7157 5728 2475 3479 PMC4753283__F1 The kynurenine pathway of tryptophan catabolism and markers of interferon-Gamma-mediated immune activation 8942 8564 23475 PMC4791550__F2 Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans 639 8651 9021 1154 10538 6774 643 PMC4850838__F2 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 51129 345 4023 PMC4872445__F2 Distinct roles of enzymes MTHFD1L and MTHFR in the folate-related one-carbon cycle 4524 4522 25902 PMC4875670__F2 Network of gene interaction NF-KB pathway obtained from the subtraction of the control Hep-2 cells 6917 171392 10913 56882 1852 PMC4902960__F6 Activation of NFKB and STATs signaling pathway in ZIKV-infected hNPCs 958 4615 7186 7187 6387 7852 7189 6775 6772 6774 51311 51284 6773 54106 7098 3661 10379 PMC4903173__F1 Foiling IDOL to help control cholesterol 255738 3949 9101 3156 9099 PMC4904747__F16 JAK STAT pathway 3717 3716 6772 PMC4940047__F2 Regulation of hepcidin production 148738 2056 57045 3570 9518 7036 3077 57817 6774 3717 PMC4947689__F1 Hcy metabolism 4397 635 4524 875 PMC4954455__F6 Working model of the molecular mechanisms of HDACi (e.g., abexinostat) on human skeletal (mesenchymal) stem cell differentiation into adipocytes and osteoblasts 1050 28999 9242 1499 249 7042 7412 1277 PMC4962366__F8 Gene network 434 181 4159 4158 7042 3827 PMC4973244__F8 Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway 6395 7099 4615 6774 PMC4978554__F1 CTLA-4 pathway inhibition 940 941 942 324 PMC4979470__F1 The NLRP3 inflammasome signaling pathway 7124 114548 3553 PMC4995089__F4 Immune evasive attributes of SpA 958 920 8767 PMC5076847__F12 Regulation of IRF1 and IRF1-dependent late-phase gene expression by IL1B after DUSP1 silencing and glucocorticoid treatment 3553 1843 3606 3659 2638 PMC5173082__F4 mTORC2/Akt pathway 3480 3091 6774 3667 5463 2146 PMC5206726__F1 Relaxation oscillations and hierarchy of feedbacks in MAPK signaling 1956 4763 4771 PMC5351205__F1 Sub-pathway enrichment analysis of differentially expressed genes (DEGs) 84693 5096 4329 79611 55902 8802 34 PMC5353654__F7 Series of functions (e.g 3033 7200 2243 PMC5360632__F1 Combined Role of Vitamin D status and CYP24A1 in the Transition to Systemic Lupus Erythematosus 1594 7421 2638 6257 6256 1591 PMC5382327__F1 Fish retinoic acid‐inducible gene I (RIG‐I) ‐like receptor (RLR) ‐mediated signalling pathways in response to viral and bacterial infections 64127 57506 7187 29110 3665 3661 91543 PMC5388243__F7 Schematic of the proposed mechanism of MIR506 induction of autophagy-related cell death in PDAC cells through the STAT3 signaling pathway 574511 6774 8678 596 PMC5392045__F1 Schematic of the stimulator of interferon genes (STING)–dependent innate immune response pathway 115004 29110 3661 PMC5398560__F6 Complement Anaphylatoxins, C5a and C3a, Suppress Interferon-Beta Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway 695 51428 29110 3661 3456 PMC5400276__F3 Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling 3454 3455 7297 6773 6772 3716 10379 PMC5426651__F13 Mechanism of GnRH-(1–5) action in Ishikawa cells 83550 1956 1950 PMC5471801__F3 Enzymes involved in the metabolic pathway of PEB regimen 5243 2950 54658 PMC5474286__F1 Schematic representation of the immune cells involved in Mycobacterium tuberculosis infection 325 3553 941 940 PMC5509150__F4 Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival 1558 1559 8529 11283 PMC5514220__F2 Involvement of sirtuins in lifespan/healthspan elongation pathways 10135 3479 2475 PMC5528622__F3 Resistance to targeted therapies in melanoma 1956 5159 3480 4893 673 5728 PMC5615248__F2 Regulation diagram 182 4851 3955 PMC5633085__F6 Tumor-induced osteomalacia 8074 2260 2475 PMC5633564__F1 Folic acid and the one carbon cycle (1-CC) 4524 4397 875 PMC5659989__F1 Overview of the role of adiponectin in the crosstalk between AT and the cardiovascular system for the regulation of cardiovascular redox state 5879 27035 9370 PMC5666046__F3 Prolonged mechanical loading beyond physiological levels on tenocytes, increases the expression of IL-1B and CCL2 6347 3553 355 PMC5702042__F8 Suggested model of activation of the NLRP3 inflammasome by Fonsecaea pedrosoi hyphae in macrophages 114548 6850 3553 3606 PMC5705427__F3 Psoriasis: A mixed autoimmune and autoinflammatory disease 51752 64167 79092 2919 2920 PMC5727251__F4 Inhibitors of the FZD/LRP/Wnt signalling cascade 147111 50964 4041 PMC5727316__F1 lncRNAs in Wnt/B‐catenin signalling 2931 324 1499 652995 729177 101805488 PMC5757547__F2 Glucose-lipid crosstalk in diabetic kidney disease 2475 23411 5465 355 7038 PMC5759086__F3 Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing 7054 1312 1621 5409 PMC5761026__F1 Simplified scheme for one-carbon metabolism 4552 1719 4524 4397 PMC5761485__F1 Biosynthetic pathway of steroid sulfates 6770 1583 1586 1528 3284 PMC5813732__F7 Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway 3082 2249 8650 51176 6929 595 PMC5842210__F1 Pathogenesis of diabetes and its complications, reflecting where CCN proteins may take part 4856 1490 8839 3491 PMC5858971__F1 IL-6 signalling pathways 102 6868 6774 PMC5891988__F2 ILC3s in the context of cancer 6774 4050 4049 PMC5968093__F1 Antibodies that target leukemic stem cells (LSCs) and blasts directly 939 945 7186 23043 970 1499 PMC6020165__F3 Proteasome Inhibitors: Structure and Function 3725 638 637 PMC6034666__F2 Engagement between the gut immune system and a probiotic (exemplified by Bifidobacterium longum subsp 6364 7097 10333 54106 5132 PMC6044347__F2 The steroidogenic pathway 3949 1583 1586 1588 PMC6064203__F3 Integrative machine learning analysis of multiple gene expression profiles in cervical cancer 6181 5178 8718 686 4831 PMC6068130__F1 Tryptophan (Trp) catabolic pathways 3620 8942 8564 130013 23475 PMC6071982__F4 Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny 949 85441 747 2194 31 51 6720 PMC6079151__F4 WNT pathway promoting endometrial carcinogenesis 1499 324 2932 PMC6122050__F1 Tyrosine metabolic pathway – highlighting the site of the enzyme defect observed in alkaptonuria and type 1 hereditary tyrosinaemia and the site of action of nitisinone 5409 1621 7200 PMC6291723__F4 Main lipid-lowering effects of berberine through the APMK pathway 3949 3184 7038 PMC6330352__F3 Cartoon depiction illustrating potential saturated free-fatty acid mechanisms that may underlie arrhythmogenic events 7097 7099 3553 3550 9118 3717 PMC6345051__F4 Visual representation of molecular interactions in the HSF flock 1380 2208 3512 930 933 6367 973 8516 10563 6363 9214 4050 974 PMC6396338__F6 Contrasting strategies for disrupting interferon (IFN)-mediated responses in hepatitis A virus (HAV) versus hepatitis E virus (HEV) infections 7098 7297 57506 3661 6773 PMC6400807__F7 The sketch of the mechanism of lncRNA SNHG16 on JAK2/STAT3 signaling pathway 3717 6774 100507246 PMC6430464__F9 Proposed model depicting the possible mechanism of XIST on mediating cell proliferation, viability and apoptosis via generating a negative feedback regulation of NF‐KB/NLRP3 inflammasome pathway 114548 7503 3553 PMC6435939__F1 Proposed platelet-endothelial cell adhesion molecule-1 (PECAM1) and Src signaling pathway activation in ARDS and in ventilator-induced lung injury 6714 5175 6774 PMC6456408__F7 Type I IFN signaling and production in Mtb-infected cells 6772 10379 3661 PMC6457213__F7 Model of cytokine-mediated rescue 3717 5292 11040 PMC6503643__F4 HSV proteins modulate key steps in interferon-related pathways 3716 6773 3466 7187 6772 3661 1387 3665 PMC6555965__F1 Schematic diagram of lipid biosynthesis pathway in Schizochytrium sp 4118 11113 355 PMC6660575__F1 Posited mechanistic frameworks implicating dietary carbohydrates and cancer risk 3486 6462 3479 PMC6707065__F1 Normal Adrenal Steroidogenesis Pathway 6770 1583 1586 8644 1528 3284 1589 1584 1585 3291 PMC6766659__F6 Pathways that mediate the effects of NANOG on COL3 expression by senescent cells 4087 4088 4092 4091 4089 79923 1281 PMC6791057__F2 Mechanisms underlying the sex-specific establishment of the Wolffian duct 1956 1950 367 2263 2118 2119 2260 PMC6801973__F3 Entamoeba sulfolipid metabolism 100188795 1733 7536 PMC6837928__F1 Folate metabolism and interaction with other nutrients such as vitamin B12 and choline 1719 635 4397 4524 PMC6857111__F11 Huaier inhibited breast cancer progression through linc00339/miR-4656/CSNK2B signaling pathway 29092 100616465 1460 PMC6882982__F6 Most significant module of PPI network of DEPs involved in ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway 1285 1281 3908 1286 3915 1282 3672 3911 3913 1288 3655 375790 1280 3918 3909 3912 3691 284217 1278 PMC6913124__F7 Putative role of miR-146a in CVB infection 7098 3654 7189 PMC6929403__F2 The ceRNA networks involved in the chemokine signaling pathway 2920 4283 5473 2921 3627 6356 6376 2791 5196 51764 PMC6949817__F8 Schematic presentation of the CBFB/RUNX3-miR10b-TIAM1 pathway 865 864 7074 PMC6964830__F5 Functional network of proteins in stage 2 breast cancer samples, (confidence level = 0.150) 60681 3671 55233 11328 PMC7002859__F1 Steroidogenesis pathway involved in testosterone synthesis from cholesterol in testicular Leydig cells 6770 3293 3283 PMC7015041__F8 Molecular mechanisms involved in PLAG1 regulation in OC cells 5324 3481 3480 3667 PMC7073175__F10 The proposed mechanism underlying the TCEE-mediated anti-inflammatory effect in ECs and atherosclerosis 3383 7412 348 4280 PMC7082274__F1 Steroidogenic pathway for aldosterone and the ‘hybrid steroids’—18OH-cortisol and 18-oxocortisol 6770 1583 1586 3284 1589 1585 1584 PMC7189297__F1 Relationship between EPO and FGF23 metabolism 2056 8074 6319 PMC7237728__F7 Effect of DFX on Mtb-infected macrophages 2597 5209 3091 PMC7289300__F5 LncRNA-mRNA expression correlation network (co-expression network) analysis of core mRNAs and their correlated lncRNAs 10916 103021165 9049 6633 4609 64063 11072 PMC7290734__F2 Type 2 immune response via ILC2s in asthma patients 85480 64806 90865 PMC7313573__F1 Figures show the metabolism and role of biotin, cobalamin, and pyridoxine in various pathways 7054 1312 1621 PMC7345582__F3 Oncogene miRs that activate the STAT3 signaling pathway and promote the proliferation and invasion of GC cells 406947 3454 122809 8835 10401 6774 3717 4609 PMC7345582__F4 Long non-coding RNAs and their downstream targets in the regulation of the STAT3 signaling pathway in GC cells 283131 100124700 100507246 3717 5820 6774 PMC7345582__F5 STAT3 signaling pathway as an oncogene factor in GC cells 595 2146 6774 9332 960 PMC7348145__F8 WDFY3‐AS2 contributes to the suppression of cell proliferation and invasion by manipulating miR‐2355‐5p/SOCS2 signalling axis 3717 8835 404201 PMC7393270__F7 Ingenuity Pathway Analysis regulator effect networks analysis of differentially expressed (DE) genes between Muc1−/− vs 5468 6514 6319 4547 2169 7421 2168 2921 PMC7404278__F1 Molecular switches regulating hair growth 6469 1499 6608 PMC7418744__F1 Pictographic representation showing the potential role of statins in COVID-19 infection 5340 3458 7124 325 PMC7432085__F5 Pathway studio network analysis of PLA2R1 and PLA2R1 promoter methylation in breast cancer 4609 3717 2101 PMC7455639__F1 Genetic variant rs2494938 of LRFN2 gene is associated with non-small cell lung cancer risk in North-Indian population 57497 1741 1742 324 PMC7492601__F7 Biological mechanism of lncRNA C1RL-AS1 in GC 283314 2932 1499 PMC7504523__F5 IFN signaling pathway suppressed by ADAR1 via the miR-302/367 cluster 57506 3454 3661 3665 7297 3716 10379 PMC7507458__F4 Reciprocal interaction between lncRNAs and Hippo cascade 9113 26524 8239 728228 102723932 378938 652995 154796 23642 100499177 253943 PMC7519869__F7 Diagram presentation of the molecular mechanism 6548 100302242 1499 595 367 PMC7533892__F5 2HG interference with the mTOR pathway and collagen maturation 64798 9682 2475 253260 5351 8985 5033 PMC7535921__F8 Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation 199990 8841 2177 PMC7539815__F4 Proposed GnRH-analog effect on NAV3 and resultant effect on leiomyoma development 2798 89795 1499 PMC7543578__F2 Sites of action of novel treatments for Graves hyperthyroidism 920 958 7253 3569 3480 PMC7603558__F6 Signaling pathways involved in the actions of the 12 herbs against OvCa 958 7099 355 PMC7679160__F8 PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion 29110 5496 57506 3661 PMC7682347__F7 NFKB/leukemia inhibitory factor/STAT3 signaling pathway in antibody-mediated suppression of Sindbis virus replication in neurons 3976 3977 6774 PMC7736343__F7 An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells 5728 7942 6774 81671 PMC7789600__F2 Roles of lipoproteins in the exogenous, endogenous, and reverse cholesterol pathways 7038 3931 4023 PMC7843693__F4 Therapeutic potential of mesenchymal stem cells in treating both types of diabetes mellitus and associated diseases 9242 7124 3667 PMC7915605__F6 Summary of steroidogenic pathways in primary trophoblast cells isolated from human term placenta 1584 1589 3290 3291 1583 1586 3283 6715 1588 3293 3292 PMC7958478__F2 Pathways linking coronavirus disease 2019 to heart/brain injury 3569 50616 3600 3627 PMC8009526__F1 Signaling networks in inflammatory pathways and risk for suicidal behavior 6476 6774 4791 7124 4790 3725 2353 3572 3586 3553 3570 6476 2353 7124 3586 6774 3553 3570 4791 3572 4790 3725 1051 PMC8015888__F8 Immune detection, inflammatory signaling and intracellular fate of MVs produced by Gram‐positive bacteria 7097 51311 54106 51284 64127 6347 PMC8021562__F6 TOPORS-AS1 regulated by VDR, interacting with hnRNPA2B1, and inhibiting the Wnt/Beta-catenin signaling 324 7421 1499 3181 PMC8096904__F5 Control Analysis of Protein-Protein Interaction Network Reveals Potential Regulatory Targets for MYCN 1956 3480 2064 3845 4149 4335 2260 5728 4084 2263 5290 4609 83463 5295 22877 4613 10608 23269 6945 4610 4601 3265 595 7046 2261 7048 4087 4089 92 4088 91 PMC8156218__F1 Pentraxin 3: a powerful orchestrator in urinary tract infection 5806 4615 7099 PMC8278082__F7 Naa10p and IKKA interaction regulates EMT in oral squamous cell carcinoma via TGF‐B1/Smad pathway 4088 7040 4089 PMC8280619__F1 Unraveling the role of liver sinusoidal endothelial cells in COVID-19 liver injury 7450 2920 2919 PMC8312177__F1 Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease 635 4397 100188776 875 PMC8375323__F4 TIMM17A Regulatory Network Contributing to Breast Cancer 10440 134266 131118 10245 29090 29928 516 291 PMC8378993__F1 Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm 3976 1270 3589 5008 6774 PMC8436520__F1 Phenotypic and immune functional profiling of patients with suspected Mendelian Susceptibility to Mycobacterial Disease in South Africa 3394 958 3716 3717 6772 9636 3594 3595 7297 6775 PMC8505648__F3 Interactions between cancer cells and resident cells 355 5728 221357 596 6772 1956 4609 7503 PMC8555850__F1 Bile acid regulation 1581 1582 2264 80270 25801 9965 1593 9420 PMC8599049__F8 Interleukin 6 trans-signaling increases prostaglandin E2 production in human granulosa cells 3717 3569 9021 5743 PMC8746762__F12 The mechanism behind the inhibition of the TGF-Alpha-induced HCC cell migration by raloxifene and bazedoxifene 7039 1956 619501 PMC8752802__F3 IFNG signaling integrity in colorectal cancer immunity and immunotherapy 3458 3459 8943 PMC8762193__F1 Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly 6772 6774 3458 920 PMC8764638__F1 Reviewing clinical considerations and guideline recommendations of C1 inhibitor prophylaxis for hereditary angioedema 5340 718 727 729 730 735 PMC8824735__F1 Structure-based discovery of selective CYP17A1 inhibitors for Castration-resistant prostate cancer treatment 1583 1586 1589 PMC8826489__F1 Circadian rhythms of 11-oxygenated C19 steroids and Δ5-steroid sulfates in healthy men 1583 3284 6822 1586 1584 3291 3290 PMC8876822__F3 Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism 1956 7450 102 PMC8906035__F1 Kynurenine pathway in Coronavirus disease (COVID‐19): Potential role in prognosis 3620 169355 3558 3569 3458 PMC8906937__F6 Solasonine Induces Apoptosis and Inhibits Proliferation of Bladder Cancer Cells by Suppressing NRP1 Expression 1950 1956 7422 2475 PMC8909792__F2 Rickettsia spp. intracellular life cycle and host innate responses 7038 4615 7097 114548 7099 PMC8909792__F3 Ehrlichia chaffeensis intracellular life cycle and host innate response 54106 51284 4615 64127 7097 PMC8928433__F7 Polysaccharide From Eupolyphaga sinensis Walker With Anti-HBV Activities In Vitro and In Vivo 3661 7099 4615 3172 PMC8938628__F12 Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting Beta-catenin/TCF4 signaling pathway 6925 324 1499 607 2932 4040 4041 PMC8948514__F1 Case series of cerebral venous thrombosis as the first manifestation of homocystinuria 4524 4397 875 635 PMC8984119__F1 Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions 5132 55902 47 PMC9015122__F2 Interaction types that are not found in 6817 6822 684 PMC9030821__F2 RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma 3627 6373 10563 6387 58191 284340 2833 10663 2919 6372 2920 2921 9547 3579 PMC9126461__F1 Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features 5879 11186 673 2885 2002 PMC9167935__F9 MSC-ACE2 Ameliorates Streptococcus uberis-Induced Inflammatory Injury in Mammary Epithelial Cells by Upregulating the IL-10/STAT3/SOCS3 Pathway 79792 114548 6774 9021 PMC9320351__F3 Vitamin D Derivatives in Acute Myeloid Leukemia: The Matter of Selecting the Right Targets 7421 6256 1591 PMC9325512__F1 CMTM6 and CMTM7: New leads for PD‐L1 regulation in breast cancer cells undergoing EMT 6364 6615 6935 961 1786 PMC9339612__F3 Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer 693222 5901 3976 3977 6774 3716 PMC9361019__F6 Stemness Analysis Uncovers That The Peroxisome Proliferator-Activated Receptor Signaling Pathway Can Mediate Fatty Acid Homeostasis In Sorafenib-Resistant Hepatocellular Carcinoma Cells 6319 1582 7018 6257 10062 PMC9370682__SF1 Design, Synthesis and Biological Evaluation of [1,2,4]Triazolo[1,5-a]pyrimidine Indole Derivatives against Gastric Cancer Cells MGC-803 via the Suppression of ERK Signaling Pathway 3008 3009 3005 3010 3024 341567 3006 132243 3007 PMC9419495__F2 Whole Exome Sequencing in Patients With Ectopic Posterior Pituitary 1499 8022 8820 5626 1000 5015 2255 6091 100188776 28514 182 6469 4853 6911 145873 134701 PMC9447342__F7 CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis 3082 4314 4322 PMC9485267__F1 Targeting p85B nuclear translocation for the tumors with PIK3CA helical domain mutations 3667 7874 2145 2146 1740 PMC9516659__F4 Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data 3486 7056 7069 3953 2940 6319 1675 3397 PMC9520191__F10 Polysaccharide from Atractylodes macrocephala Koidz binding with zinc oxide nanoparticles: Characterization, immunological effect and mechanism 114609 4615 7099 3553 942 941 PMC9541002__F2 LINC00467: an oncogenic long noncoding RNA 100616159 102465859 51548 1499 2146 94031 84791 PMC9541233__F1 Are UMFA (un‐metabolized folic acid) and endocrine disruptor chemicals (EDCs) co‐responsible for sperm degradation? An epigenetic/methylation perspective 6573 113235 4397 1719 PMC9548139__F1 Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study 6770 1583 1586 6783 6822 1589 1588 51144 1584 1585 PMC9551057__F8 Excretory/secretory proteins inhibit host immune responses by downregulating the TLR4/NFKB/MAPKs signaling pathway: A possible mechanism of immune evasion in parasitic nematode Haemonchus contortus 4615 6774 3586 324 PMC9559463__F1 Long-Term Management of Advanced Basal Cell Carcinoma: Current Challenges and Future Perspectives 6608 51684 5727 PMC9605147__F1 Let-7 microRNAs Are Possibly Associated with Perineural Invasion in Colorectal Cancer by Targeting IGF Axis 3667 3643 3482 8660 PMC9681882__F3 Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways 7060 4060 84735 290 347 1311 PMC2663408__F15 The Aldo-Keto Reductase Superfamily and its Role in Drug Metabolism and Detoxification 1645 1646 1109 1553 PMC2842525__F2 IFNA signal transduction 7297 3716 6773 6772 PMC2998292__F2 Pathway Analysis Models for the Tamoxifen (TAM) Pathway tested with data from the Placebo (P) and Tamoxifen (T) arms 1555 1557 1576 1565 1559 PMC3085438__F5 Working model for the role of CCN6 in breast cancer invasion 3479 6935 8838 3480 3667 PMC3109034__F6 Working model for the role of the miR-29 family in TGFB2–mediated signaling 4088 407021 407026 PMC3668775__F9 Proposed model for the attenuated response to type I IFNs in human pluripotent cells 7297 3716 6773 10379 9636 PMC4675542__F2 Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians 5743 5771 4353 3458 5742 5777 3620 5740 3460 3459 3659 5580 PMC4925073__F1 Pathway of codeine metabolism in a CYP2D6 extensive metabolizer 1565 7364 54658 PMC5568613__F1 Pathway of corticosteroid synthesis in the adrenal cortex 1583 1586 1584 1585 PMC6011013__F5 Integration of mRNA data and CNAs profiles: BMD+DAD-screening network using Coxnet (top) and ADMMnet (bottom) methods with mRNA expression data and the integration of mRNA data and CNAs profiles 2264 341568 2740 121275 56832 10798 391112 2741 777 3443 PMC6020395__F1 The vitamin-D metabolic pathway 1591 1593 1594 120227 PMC6051466__F2 Low antiviral gene expressions at the time of antiretroviral therapy (ART) initiation in cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) group 64135 24138 51284 3665 10561 6352 3433 4599 3456 79132 8638 5610 4939 3434 9636 4938 4940 3437 PMC6585752__F2 Characterization of network connectivity between highly expressed interferon (IFN) response genes 3433 55008 55601 3434 54877 6614 5610 4599 11274 8638 64135 94240 24138 51191 3437 2537 54739 129607 91543 4938 4940 4939 64761 PMC6767864__F2 IFN-λ4 Conundrum: When a Good Interferon Goes Bad 3441 3455 163702 7297 3716 11274 9636 PMC7188552__F2 Bile acid synthesis pathways 1581 1593 9420 1582 PMC7204122__F4 Knockdown of IL6 in human endothelial cells affects the gene expression of proteins known to be involved in IL6-mediated signaling 3569 3572 6774 9021 PMC7217380__F2 PPI network and module analysis of HCC 1557 4493 4495 10844 PMC7500474__F1 11-Oxygenated C19 Steroids Do Not Distinguish the Hyperandrogenic Phenotype of PCOS Daughters from Girls with Obesity 1586 6822 3284 1584 3291 PMC7716168__F6 The role of MOB1A in the survival of GBC cells under glucose-deprivation conditions 55233 3569 6774 PMC7774932__F7 Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus 2170 5468 2167 5467 5465 PMC7774932__F8 Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus 5467 5468 2167 2170 5465 10062 PMC7933770__F2 PPI network of the DEGs, and the expression levels of the hub genes in PDAC tissues and normal tissues 4323 2043 5166 55601 PMC7938660__F1 Metabolic formation of hydroxynorketamines from ketamine 1548 1555 1576 1577 PMC8918542__F1 Clinical Importance of Potential Genetic Determinants Affecting Propofol Pharmacokinetics and Pharmacodynamics 54600 1555 1559 6817 PMC9158472__F6 NFE2L3 as a Novel Biomarker Associated With IL-2/STAT5/NLRP3 Signaling Pathway in Malignant Pleural Mesothelioma and Other Cancers 114548 9603 3565 3567 3586 3596 PMC5134418__F2 Depiction of prasugrel metabolic pathway 1555 1559 1557 1565 1576 PMC7685564__F1 Cross-Kingdom Activation of Vibrio Toxins by ADP-Ribosylation Factor Family GTPases 1080 382 375 1362 PMC4768675__F9 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity 1540 9140 9474 79132 57506 85451 PMC7957493__F4 Mutations in components of niche-signalling pathways lead to “ISC emancipation” and subversion of homeostatic mechanisms 26585 6423 6422 6425 6424 650 3082 3605 652 1950 54894 23765 960 324 2932 8313 5728 4851 55294 4089 3280 6010 430 4609 8549 6591 PMC10003241__F3 Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease 4040 4041 54407 440 9056 2744 860 6510 1277 6507 PMC10031043__F1 Maintenance of genome integrity by the late-acting cytoplasmic iron-sulfur assembly (CIA) complex 22 55847 493856 27158 10539 64428 9391 51647 64210 5558 5426 51750 1763 4595 4913 PMC10031257__F3 Focal adhesion proteins in skeleton and diseases 6714 7448 4312 4319 6662 6774 860 11096 PMC10039784__F1 Deficient radiation transcription response in COVID-19 patients 4609 472 545 4193 355 581 10572 94005 84883 3486 5728 596 64065 729 1017 841 7249 64326 637 6477 842 836 PMC10040549__F1 Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications 2182 2241 7018 10162 8031 55240 PMC10040851__F6 Single-cell atlas reveals shared and distinct immune responses and metabolic profiles in SARS-CoV-2 and HIV-1 infections 5720 10379 5771 3108 3455 3433 10135 3123 6717 6648 5359 3117 5721 684 968 128486 10410 3134 51371 7128 942 3107 6872 8767 9111 1445 253943 972 57823 9021 54809 57674 2922 23070 11054 9961 5770 3106 3665 391 2534 952 1267 100188776 60 103 64761 83666 5683 317649 3454 22944 7454 4149 324 54625 2634 1439 6402 81894 5493 10695 100187761 5660 8417 4067 9332 6850 PMC10041388__F1 Metabolic reprogramming in cancer: Mechanisms and therapeutics 3099 2023 3939 2539 8473 5106 PMC10041518__F3 Altered nucleoside handling facilitates cancer cell immune evasion 8833 3615 3614 4860 920 2766 367 158 8205 PMC10041561__F17 Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs 2006 2171 2166 7442 7098 3661 7124 4599 4600 4938 PMC102186__F9 Ras-mediated signaling pathways 4893 387 5879 6010 6722 1386 2002 PMC1052008__F3 GSK-3 as a convergence point in hypertrophic signaling 5163 3611 4775 1499 2626 PMC1082717__F1 The mTOR pathway and the potential intersection with LMP2A-activated PI3-kinase/Akt signaling 2475 1977 595 4609 4953 3091 PMC1133795__F3 Functions of NFKB1 and NFKB2 in immune cell biology 4050 4049 5970 5971 PMC1134985__F3 Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? 6476 11261 1040 7465 PMC1180390__F5 Signaling pathways implicating p120-RasGAP 126669 2885 5906 889 6654 PMC1193534__F1 Comparative Genomics of Natural Killer Cell Receptor Gene Clusters 3813 3802 920 5728 6714 207 5777 3707 3937 2885 6464 7409 1605 27040 PMC1236696__F1 IKK/NFKB signaling pathways 4055 3553 5971 7412 3383 644076 6256 3661 PMC1236700__F2 Regulation of the extrinsic pathway by Hsps 7124 8772 1616 8717 7186 11140 572 90427 596 637 581 7185 PMC1288546__F1 Human SHH-PTCH-GLI pathway (left) and its links to human diseases (right) 2735 2736 2737 PMC1375233__F2 Association between human TLRs and adaptors determine each TLR-specific signaling pathway 54106 51284 7097 7099 7098 7100 114609 4118 4615 7189 3661 1386 PMC1383660__F6 Intracellular signalling pathways activated by leptin 387 5140 6774 1050 4852 PMC1386115__F3 Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs 7099 7098 64127 3661 19 9619 3553 7124 4512 4318 PMC1435944__F6 Graphical Interface for the KnowledgeNet of candidate genes for hypertension 7421 3667 3479 2778 3952 5468 8431 3630 155 4852 6347 4311 154 4883 4878 1392 183 4879 4882 5972 57085 1909 4929 5743 1535 5652 1956 PMC1479345__F4 Pathway analysis 3725 2006 7177 3082 3508 3551 2779 3952 3263 5105 1852 650 3209 2171 695 6059 6622 PMC1479345__F5 How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome 1856 4942 5347 6932 1638 7030 10381 8175 10291 PMC1482699__F5 GenMAPP growth hormone (Gh) signaling pathway 367 100187761 51738 6670 6667 50808 2691 6752 805 2692 142679 5045 1050 1051 1052 11122 2690 8835 122809 6777 2002 6775 9111 2534 1398 2887 1610 PMC1502564__F3 Model diagrams indicating regulation and function of E47 activity 9021 2672 8328 PMC152905__F6 Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line 7517 7516 56852 51455 PMC1572165__F3 Schematic drawing that shows the importance of cell-to-cell and cell-to-matrix-interactions in endothelial cell survival 1499 1003 581 572 3458 PMC1592643__F3 An altered balance of proapoptotic and antiapoptotic molecules in trauma patients' T cells could indicate specifically increased vulnerability to apoptotic depletion 7124 637 572 27429 56616 317 6093 2021 790 355 2620 11124 1613 23604 939 8718 PMC1594921__F5 Presymptomatic and symptomatic infections including the inflammatory cytokines TNFA, IFNG, and ILB 10581 2495 10855 5721 7124 3458 5724 29851 717 978 355 5966 972 28996 7097 3937 5494 834 929 5970 1536 6891 3606 PMC1594921__F6 Immunological regulatory IL-10 and MAP kinase pathways 2353 5594 7189 3603 1386 6416 1432 8767 3727 5743 100 2057 2114 9021 3725 920 4342 847 842 2069 1398 5925 10197 2246 4842 5728 6670 PMC1601944__F1 HIF-dependent VHL pathways in oncogenesis 7428 7039 1956 2056 999 PMC1617297__F2 Cell-signaling networks induced by Pichinde virus infection as analyzed using the Ingenuity pathway analysis knowledge base 1909 1805 23236 2272 867 4609 1959 5970 1869 7507 5817 1639 5584 5728 6722 7514 2353 5241 4794 7707 7015 5925 7161 7157 2068 5981 1871 1870 3399 405 PMC1618798__F3 Extrinsic apoptotic signaling pathway 7124 355 8772 637 PMC164216__F5 TLR signaling pathways 4049 7097 7099 4615 7189 10454 PMC1664665__F2 Regulation of the axon cytoskeleton by PI3K signalling 998 6010 2932 324 PMC1665458__F7 Proteins differentially regulated in RCC involved in carbohydrate metabolism are shown overlaid on the glycolysis and gluconeogenesis pathway KEGG #00010 diagram 226 2026 5106 8802 3939 1892 10327 PMC1705513__F1 Inflammatory pathway in psoriasis 999 6364 2826 1235 3383 969 1236 914 9308 6366 6348 6351 6363 10850 7039 3479 4803 1878 7412 947 PMC1716221__F1 Dominant role for glucose in B cell compensation of insulin resistance 3479 3643 8660 5170 2645 2308 PMC1774081__F6 Math1 signalling pathway 3280 5879 885 2695 PMC1782438__F2 Role of adaptors in T-cell signalling 920 27040 2885 2534 3702 3932 7408 998 PMC1798432__F8 Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages 3458 7099 1386 PMC1804347__F4 Systemic sclerosis: a prototypic multisystem fibrotic disorder 7046 998 5879 6010 23118 10454 5062 6667 2113 1958 PMC1817784__F2 Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders 7249 7248 6009 2475 29904 PMC1828071__F1a Intracellular Signaling in Insulin-mediated Regulation of Drug Metabolizing Enzyme Gene and Protein Expression 3479 2885 1398 5163 5164 2887 572 2931 7249 7248 5140 6009 2475 253260 1975 1977 2308 PMC1851054__F6 SFK-dependent PI3K-ERK2 and phospholipase CG-JNK1 pathways 3133 962 100507436 940 718 7409 5879 5058 PMC1852708__F6 Illustration of key proteins in the Rho GTPase signal–transduction pathway, focusing on the KALRN, CDGAP, and MYLK genes 2048 4914 387 6010 998 4638 PMC1855985__F1 Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4 1956 3845 6416 3265 2065 2066 2263 5597 5598 369 673 5600 6300 5603 2261 2264 207 208 5595 6198 6199 PMC1856802__F5 Canonical Wnt signalling pathway and its APC partner in colon cancer development 999 1499 2534 2241 607 PMC1862519__F1 Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons 627 2549 2885 5266 126669 207 PMC1876599__F3 Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR 2885 2875 5894 6774 6613 9112 10286 3066 2274 27043 367 PMC1877048__F1 Nutritional Route Affects ERK Phosphorylation and Cytokine Production in Hepatic Mononuclear Cells 929 7099 2002 6722 PMC1892100__F1 Image showing the human insulin signaling pathway from BioCarta 2885 50964 3667 9846 5894 2002 6722 PMC1904449__F3 In silico modeling derived from Pathway Assist software analysis of differential gene expression in JRA neutrophils compared with healthy control subjects 22937 5757 978 5898 2936 133 3122 2354 10578 7124 9308 10673 4170 2242 PMC1934514__F4 Schema outlining the signaling mechanisms reported to be involved in GLP-1R-induced differentiation/neogenesis of pancreatic precursor cells, proliferation and in the prevention of apoptosis 650 685 1956 5266 8660 2475 PMC195990__F5 A model of Hip1's role in lung branching morphogenesis 6469 3092 2255 PMC1964512__F3 Type I IFN innate immune response to adenovirus-mediated IFNG gene transfer contributes to the regression of cutaneous lymphomas 6672 4939 259197 6347 6772 9111 3627 10537 9034 3965 3439 6095 2254 6364 3665 5359 9447 4332 91543 3431 886 2620 4938 8773 837 4283 1325 8835 6375 6367 1628 PMC1986651__F1 Regulation of cell proliferation and cell death by PKCE 5163 637 5164 572 2002 PMC1988867__F7 Ingenuity pathway analysis showing regulatory relationships among differentially expressed transcripts 5228 7057 3488 6696 2002 885 3952 4792 2353 5327 5055 1601 2878 3283 3939 4502 6872 PMC2063755__F1 Signaling events during EMT 4087 2303 1499 51176 2932 1398 6714 57504 3065 3066 3611 PMC2071927__F2 TUNING IMMUNE TOLERANCE WITH VASOACTIVE INTESTINAL PEPTIDE: A NEW THERAPEUTIC APPROACH FOR IMMUNE DISORDERS 7432 3458 929 7099 3716 3717 6772 3659 3726 6908 2002 PMC2075270__F1 Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle 3630 3667 5266 7248 2475 29904 1938 PMC2099624__F9 Schematic model of Nrf2 regulation by Keap1 9817 9978 8452 4094 PMC2136409__F8a Genetic and epigenetic mechanisms of gene regulation during lens development 652 9355 655 6657 3280 6496 5080 2138 2301 1000 1017 PMC2153436__F4 Immune Response and Cell Cycle Networks 732 731 717 6688 5648 944 716 3340 715 1493 5696 727 5465 7124 335 4771 5340 6714 7189 6289 4751 10460 1894 29128 4288 10615 5888 672 9133 991 9055 890 332 1063 4173 5347 PMC2168342__F7 Matrilysin and stromelysin-2 differentially control apoptotic transcriptional response 3486 1437 7124 219699 4804 11213 3656 8737 8767 6885 100506742 3304 5295 8682 572 7532 10572 29775 596 5728 56616 330 387 4583 388 8915 836 27429 90427 9531 28996 5916 5915 11083 7157 5885 2068 10114 9516 4609 1649 4319 7422 3569 355 351 8837 840 8772 837 6647 8877 6777 3091 694 2932 PMC2173816__F3 Down-regulation of the inflammatory response 8195 637 5163 842 836 PMC2175514__F5 Transcription regulatory network indicates utilization of various transcription factors following activation of TLR7 6775 51284 51135 3656 3654 7297 3665 4513 7185 6352 1236 960 6648 9636 PMC2203613__F10 Functional interacteome of all parietal cortex proteins 2946 4747 351 2746 7040 1950 1152 5743 4133 3725 2247 5733 5586 6624 226 5599 2641 2203 PMC2234434__F3 Genes involved in apoptotic pathways were altered in type II cells isolated from Stat3Δ/Δ mice 1675 4908 351 7175 1398 1101 5728 831 572 2176 100187907 2934 1386 112483 PMC2262896__F4 TCR signaling pathway 940 6461 3932 2534 867 1445 27040 3702 286204 5879 7006 100124696 1401 4750 4751 2002 PMC2268699__F1 p38 MAPK canonical signalling pathway 355 8772 8717 7186 1616 7189 10454 9261 7867 4149 6772 1386 2002 6722 PMC2279152__F1 Apoptosis signalling pathways 637 581 317 596 27429 836 331 8772 PMC2279300__F6 Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors 445347 10006 6654 2059 7410 PMC2291030__F3 EGF signaling pathway generated by the Ingenuity Pathway Analysis (IPA) software 1950 5335 2885 6774 6722 2002 PMC2312359__F4 Composite list of expressed genes and enriched transcription factors implicates specific regulatory networks 2886 2064 430 83855 4601 5978 4691 4791 4149 6670 4613 1874 2100 4609 1958 7029 1871 1869 6256 54345 1876 687 1387 1870 1959 1386 4862 7421 7018 4097 4783 4209 4060 4802 9242 5989 4800 6929 6667 405 3091 6097 23493 2099 7068 1960 6257 3280 9575 6258 3158 4929 4212 5089 6722 2355 466 2353 3727 4094 1390 3725 4778 122953 10538 PMC2390552__F7 Analysis of FGF signaling processes in ERK1MO and ERK2MO gene expression profiles 10818 2885 50964 79801 4893 64321 369 6670 4838 100131390 9261 572 2002 1385 PMC2410087__F1 Example of EGFR-mediated signaling changes, a commonly disrupted pathway in lung cancer 1950 1500 2887 5337 2886 5058 6774 54623 5598 3717 3716 3265 6464 2002 8036 6772 2549 3725 10188 1759 4893 2353 998 5595 5879 PMC2447903__F8 TWEAK killing 8717 7186 7187 8772 PMC2491602__F6 TNFA signaling pathway 8717 7186 8772 PMC2492871__F6 Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR2 (A-B) 23574 5270 2316 6690 367 8728 PMC2500163__F4 HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study 4036 7436 355 338 6189 6129 PMC2522278__F2 Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System 1947 2321 2260 6478 2931 369 324 8312 5594 1499 6925 4312 1950 1956 6464 2885 5900 55770 26230 5879 57381 54509 388 998 5062 6772 3725 1386 PMC2527273__F2 The signaling pathway of Type II, FasL signaling-induced apoptosis, adapted from Bagci et al 836 637 841 842 581 PMC2537559__F5 Alterations in adhesion-mediated signaling and cytoskeleton remodeling in metastatic cancer 5328 5327 7422 5329 331 5728 3611 1793 7409 7204 286204 387 3265 1977 7458 4088 PMC2553572__F2 DSB repair pathways 472 675 5888 5893 55775 11284 7515 7518 2067 PMC2559887__F3 Ingenuity pathway analysis on NFKB related gene network 1628 2542 5175 135 7188 51079 1622 2 7538 3726 4616 5467 1376 5747 4053 10912 6678 5577 7057 6194 9470 8574 PMC2561291__F1 Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions 7099 4615 4118 3654 51135 7189 29110 3661 3665 108348016 3433 3627 7124 9021 2597 PMC2564980__F5 Genes with differential expression in the carcinoma and papillary adenocarcinoma tumors were assembled into distinct metabolic pathways 10468 3624 3915 3908 7057 1956 4086 4088 4089 6714 6010 998 545 10000 894 5663 23385 8326 6925 2634 1499 8325 2932 324 PMC2565686__F6 Merger of the interaction maps for the three human proteins ING1, MEKK, and p38a (p38MAPK) based on empirical data retrieved from the STRING database 3621 5928 5931 3066 4616 10912 1647 8819 25855 3065 25942 29127 55929 5111 5879 5880 998 701 55257 7185 2033 302 860 7157 8312 85458 5781 7529 5777 7534 7533 10971 7532 7531 2185 5606 5603 5608 1844 6416 1846 2002 2005 8986 994 6772 466 995 9043 1460 4149 1849 3553 1843 5970 5600 6667 9149 1459 2625 9261 11221 4609 5371 2764 836 3875 4599 4654 2534 3001 948 958 7124 1386 4205 5319 5778 5925 2885 3725 2353 1387 4208 80824 8569 8550 2872 1385 9612 1649 7535 PMC2577715__F9 Nrf2 and transcriptional regulation of Gamma-GCSh expression 8452 9817 7975 PMC2579334__F3 Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure 6844 1398 5728 2885 5163 2534 572 5140 1384 2887 1977 PMC2584013__F23 TNF-induced and ROS-dependent events in target cells: the role of JNK activation in mediating cell death 8772 5879 8717 7186 637 317 PMC2585009__F4 HIV-1 Activates Macrophages Independent of Toll-Like Receptors 7124 2260 8717 1616 7186 50488 5058 7531 2885 5062 5582 7786 4296 4216 4215 5606 5605 5609 1849 5594 5595 5599 1432 5598 6772 1386 6667 7867 8771 150 5999 8550 9479 PMC2585009__F7 HIV-1 Activates Macrophages Independent of Toll-Like Receptors 7099 7098 3661 29110 51135 10010 3654 7189 23118 10454 7124 148022 4615 114609 4118 PMC2603135__F6 Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data 472 3065 672 4193 4436 6241 6240 2177 572 4171 6118 641 26277 5810 5111 PMC2624576__F1 Alternative splicing in the NFKB signaling pathway 7124 114609 4615 3656 1540 3654 51135 23118 7189 10454 8717 7186 PMC2634657__F2 Leptin Neuroprotection in the Central Nervous System: Mechanisms and Therapeutic Potentials 2056 3717 2885 5163 5164 1958 627 9021 2932 2308 PMC2637184__F1 New central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9 7039 4088 10013 4092 84962 22974 7852 6387 1894 387 1103 2064 83737 4086 7791 4067 1399 3932 2534 PMC2642659__F2 Visualization of molecular interaction and reaction networks in the KEGG database 6714 2695 998 4008 8826 1499 387 3480 2241 3643 2064 4089 4088 2260 51701 5624 324 4040 4041 9350 6500 6477 8454 9978 9475 23002 PMC2642890__F2 Posttranscriptional regulation of gene networks by GREs 4088 4089 4092 472 545 8900 4193 7465 3662 1017 4602 5347 3725 4189 8493 1647 4802 25 10006 861 8204 25942 196 1869 3621 7832 2308 2114 3164 993 5914 2960 902 1022 355 7124 6477 5515 6446 7337 1959 604 581 637 572 317 27429 7494 56616 2021 8915 7185 3298 4306 5481 790 6093 4609 PMC2645305__F3 Airway Smooth Muscle Growth in Asthma 7249 6009 2932 2475 1998 1977 4553 PMC2645908__F5 Model showing RBR3 role in the RBR/E2F pathway controlling the expression of MCM2–7 genes, DNA replication, and cell transformation 4172 4174 4173 4176 4175 4171 PMC2648232__F6 Pathway mapping of OPC differentiation inducer genes 54413 11221 1742 7223 4155 5795 5354 5801 10100 7043 PMC2648546__F8 A new feedback loop for p53 pathway 1017 4193 581 PMC2649208__F2 Molecular interaction map displaying the functional interaction of genes in the MEK/ERK output profile with established roles in ERK signaling 867 2885 1263 8061 8870 4609 1958 2115 2118 2119 595 10253 2353 1848 1846 81848 200734 PMC2654353__F5 From nutrients to HIF and from HIF to metabolism 2475 3099 7249 7248 5163 5230 3939 PMC2655983__F3 Simplified version of colorectal-cancer biological pathway in KEGG database for genes with mutation data in COSMIC 324 1499 387569 5266 3845 673 4089 PMC2656226__F6 Mitochondrial regulation of the apoptotic pathway is altered in disease and modulated by sirolimus treatment 7124 666 3313 4792 4221 637 599 11218 572 7832 694 1610 8682 27429 3329 8837 56616 790 2309 PMC2660918__F2 Hypothetical model for the end-joining mechanisms during CSR 7374 4436 142 545 472 4361 10111 7486 7518 7515 PMC2661568__F6 Schematic model of sequential hippocampal aging changes 6646 348 347 PMC2662295__F5 TRAF6- and MEKK1-mediated signal for IFNB production in the RLH/IPS-1 signaling pathway 8772 7187 7189 3661 PMC2666844__F3 In the absence of Wnt stimulation, the APC (adenomatous polyposis coli) forms a trimeric complex, known as the “destruction complex,” with glycogen synthase kinase-3B (GSK) and Axin 4513 324 8312 8313 1499 PMC2668236__F2 Major pathway and inflammatory mediators of sepsis and its related conditions 929 3661 3383 7412 7124 7018 PMC2671916__F6 Novel functional modules with dynamic gene expression changes potentially linked to prion pathophysiology: (A) androgen metabolism, (B) iron metabolism, (C) arachidonate/phospholipid metabolism 80270 1622 3077 4050 4049 5228 272 PMC2674747__F1 Illustration of differences in the expression of genes for early steps of sphingolipid metabolism using a KEGG-based microarray analysis tool (GenMapp v2.1) that has been modified to display this pathway more completely (www.sphingomap.org) 8877 130367 56848 56624 427 91012 79603 29956 204219 10715 9514 64781 9331 PMC2674807__F2 Common polymorphisms in the genes associated with Alzheimer’s Disease (AD) 2 6653 6622 4023 348 351 4311 3416 735 23385 7124 836 4922 2932 4137 840 PMC2679751__F7 Proposed model for functional interaction between Ncs-1a, Pi4kB, and Arf1 in trafficking and secretion 652 23413 5298 375 PMC2679904__F1 TLR mediated signaling 4615 114609 51135 3654 7187 29110 7189 23118 257397 3661 3660 PMC2682371__F2 ErbB proteins are type I transmembrane receptor tyrosine kinases 2065 2066 1956 50964 203 6714 2475 6774 4609 2353 PMC2684849__F3 Transcriptional regulation of human small nuclear RNA genes 55814 55290 6908 29940 7295 PMC2685661__F10 NO/cGMP and calcium signaling in osteoblast mechanotransduction 6890 6722 2354 PMC2685981__F1 Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis 255631 3428 5970 6715 79058 3329 3977 6331 491 10163 8455 928 7099 5091 3596 3952 2191 8543 3630 3565 5590 7124 6667 2806 3566 6385 3303 64332 7852 9516 9659 3552 949 605 6840 948 PMC2685981__F3 Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis 5443 2099 6715 949 3082 3383 920 2625 2022 7039 975 604 3596 7040 928 3567 207 5468 940 64332 1440 5728 7292 7852 6469 2335 3565 5196 3553 3600 3329 6714 1432 PMC2688935__F3 Networks used to generate simulated data 5335 5578 1950 23624 374 5747 1398 4609 25759 369 6654 3265 2885 54433 2475 572 10718 145957 PMC2694962__F1 Schematic illustration of overview of one-carbon metabolism pathway, linking to methylation reactions and nucleotide synthesis 4552 4548 635 5981 4524 PMC2697619__F5 Proposed signaling pathways by which the Tec kinases regulate JNK activation, actin polymerization, and cytokine expression in LPS-stimulated neutrophils 929 3929 7099 7006 100124696 3553 6850 998 PMC2706609__F1 ERK1/2 pathway in airway epithelial cell responses to cigarette smoke 2885 5894 4312 6667 1950 1956 PMC2710522__F1 Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data 685 7039 367 10718 1950 145957 2065 2064 2066 2885 6654 2549 126432 9610 7410 5058 5163 5728 3984 6009 2475 572 6772 6774 PMC2718747__F10 A model of EGF/EGFR-induced inhibition of a Luminal-A phenotype in MCF-7 cells 2625 1956 1950 PMC2719801__F3 Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways 6517 3643 6655 2549 5290 8503 5291 5289 5599 10746 6198 6885 8491 9882 23433 10580 5563 5781 PMC2720036__F1 Selective Raf Inhibition in Cancer Therapy 6714 2885 27068 673 572 573 596 595 2002 PMC2720036__F5 Selective Raf Inhibition in Cancer Therapy 8533 10469 1460 5876 6237 24148 5295 59349 1956 4893 22800 1398 55872 369 5159 10818 1373 256281 22808 673 7532 11339 5594 5906 3265 5300 7534 5894 207 3845 10971 5911 596 7531 23162 5595 5925 5037 5516 7533 5934 7203 6714 8625 3717 573 2783 7409 5598 8837 2782 2908 3716 3932 5499 5590 5580 1760 3643 409 283455 6251 5500 3560 6915 5592 10253 51555 4058 5063 54331 5578 3856 8036 572 5058 3880 81848 5581 5335 5921 3875 4609 2786 5062 2902 7157 11140 2885 1435 9610 PMC2722023__F4 Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program 9685 23423 161 9342 55738 5863 23062 8876 1384 22821 10654 10640 79784 65985 5898 51109 63924 2632 5625 382 9056 6721 6720 27346 5468 658 5997 51 47 10747 230 10525 717 3156 3795 51085 50486 5979 4830 56034 9641 91543 79094 8517 5004 312 219 4615 9404 51135 3801 2289 8470 25816 55620 55504 5947 9530 5167 56624 PMC2724002__F2 Controlling Hair Follicle Signaling Pathways through Polyubiquitination 6469 2735 2736 2737 PMC2724029__F5 Signaling networks upregulated in migrating neuroblasts 8997 23136 1124 11275 8874 7204 23263 7410 85458 9175 4216 6416 85451 1386 PMC2724989__F1 Macrophage activation by endogenous danger signals 6041 8772 7187 10010 7186 7189 29110 PMC2735125__F7 HP1 Proteins Form Distinct Complexes and Mediate Heterochromatic Gene Silencing by Non-Overlapping Mechanisms 26523 11261 63928 9541 PMC2735334__F1 Carcinogenesis of Bcr-Abl in CML 613 207 572 596 PMC2736328__F2 Transcriptional regulation of cytokine function in airway smooth muscle cells 7124 6850 6714 8717 7186 7188 8915 10892 7187 51135 100187907 PMC2737689__F2 Multiple isoforms catalyze each step in the glycerol-3-phosphate pathway of TAG synthesis 2180 84803 137964 150763 4018 10554 10555 56895 55326 56894 8694 84649 5091 PMC2739295__F6 Gene Expression Profiling in Cells with Enhanced Gamma-Secretase Activity 5624 2932 1499 4040 4041 5793 6477 960 6696 387 7431 7378 PMC2743399__F3 Improved readability and performance with multi-scale information integrated in pathway visualization using metagraph 3955 1855 55534 8650 113878 1387 10683 3280 9612 5663 51107 1487 3065 8646 10468 5922 11197 1634 55851 2885 9978 1386 355 4773 2932 3727 8550 PMC2747343__F1 Ingenuity pathway analysis shows 17 genes from the 180 genes associated with the NF-E2-related factor-2 (NRF-2)-mediated oxidative stress response pathway 847 6647 2950 10327 316 3725 5829 468 1356 5629 2512 873 5611 26353 373156 10574 PMC2749258__F3 Approaches to biomarkers in human colorectal cancer 55914 4601 7392 4436 11197 4041 90780 1601 387 960 10856 2932 8607 10023 6934 6925 1499 8507 324 10454 51701 4316 56547 4897 7422 652 PMC2751999__F6 LPA effect and signal transduction pathway 2695 4018 5894 4099 4026 1432 4609 6772 6010 7248 7249 2475 PMC2755790__F1 Network analysis of differentially expressed proteins (red symbols) involved in arteriogenesis 2335 4843 4842 4846 1948 387 6722 3725 137735 11034 PMC2756045__F2 LKB1-AMPK pathway: metabolism and growth control in tumor suppression 54861 8844 200186 4133 10014 3172 7249 5209 3667 PMC2756331__F1 Trk receptor tyrosine kinases and major signal transduction pathways 627 4803 4922 5163 2885 10818 998 6010 2931 572 PMC2763495__F4 AMPK–p53 pathway in metabolic adaptation 57103 126129 9997 PMC2763943__F2 Nox proteins in signal transduction 27035 8717 9261 5163 5058 PMC2768039__F2 Genetic Basis for Kidney Cancer 7428 8453 9978 7039 PMC2774770__F1 IL-4 induces an alternate pathway for BCR signalling 6850 4067 695 29760 5163 2885 572 842 8915 10892 5894 6714 3725 1386 2353 PMC2774854__F1 Schematic overview about TCR-dependent signalling pathways 920 940 93129 84876 80228 2885 27040 2534 3932 6786 998 3558 PMC2775888__F2 Cellular mechanisms by which flavonoids and their metabolites protect against neuroinflammation and neuronal injury induced by 5-S-Cys-DA, DHBT-1 and related ROS 572 6772 3458 PMC2781055__F3 Ingenuity pathway analysis (IPA) of microarray data generated several genetic networks 2776 1910 7852 3164 4133 5604 10468 85451 2674 2690 9456 3927 2065 1398 7849 414325 6364 2212 3297 729230 351 6774 5617 7200 3814 2688 5367 25970 64111 10886 5697 4886 5873 PMC2783351__F2 “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia 7099 929 4615 114609 3654 7189 51135 23118 257397 PMC2785525__F1 The Anticoagulant APC Pathway 324 7018 100306940 2160 5340 PMC2785525__F2 Cytoprotective APC pathway 324 3383 7412 PMC2785769__F7 Proposed pathways for promotion (A) and progression genes (B) influenced by TLR4 7099 374 2069 6696 1839 5901 3371 1956 7077 2697 4609 3159 6352 729230 7402 8534 6279 2920 5744 383 4953 PMC2787666__F1 Base excision repair (BER) pathway 4968 7374 4350 142 7515 5423 5111 2237 PMC2788255__F6 Wnt signalling pathway downregulated in osteosarcoma 5584 8321 2535 7976 8322 5590 8324 1855 1857 10023 324 1499 26190 1487 51701 51176 79923 4609 3725 5328 PMC2789670__F5 Summary of glutathione (l-Gamma-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C 9817 571 23764 2730 2729 2937 2936 2745 PMC2790076__F5 Comparative Analysis of Gene Expression Patterns and Cell Phenotypes between Cervical and Peripheral Blood Mononuclear Cells 23533 5290 7096 7097 5879 7124 114609 3606 8517 4791 1147 3989 4792 929 10454 23118 7189 7099 4615 5594 3654 2353 4133 941 942 7100 3663 51311 51284 54106 6696 7187 3661 3627 4283 3454 PMC2790273__F1 Possible cross-talk between Nod2, TCR, Cd28, TLR and TNFR family members in regulating NFKB 940 7186 4615 7189 7187 10892 64127 10454 257397 23118 5971 108348016 5970 PMC2790753__F1 Microarray data for the genes in the pathway coined from the central genes in the KEGG pathways ‘insulin signaling pathway’ and ‘adipocytokine signaling pathway’ 948 155 3551 8517 4792 4793 8717 7132 7186 7124 7133 2180 2182 5970 207 208 51703 6720 5571 51422 9021 2194 5211 5214 1374 1376 3716 6774 3717 3952 3953 5225 5105 867 2308 5468 6256 6257 5507 51094 79602 10211 23265 6517 2319 PMC2796172__F2 Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics 2821 226 7167 3704 5226 7086 5230 5223 2023 6888 4831 5424 205 50808 5313 3939 1737 5160 5091 5106 7038 3422 2168 26873 4942 8659 2744 1431 13 3418 27346 3419 2194 31 6342 50814 2271 4190 4191 2746 2806 51 37 1666 1891 1892 34 3032 PMC2796982__F3 Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway 7976 57216 7471 23002 6010 324 1499 998 PMC2798195__F9 Proposed mechanism for pathogenesis due to H 929 7096 10333 7097 7099 PMC2798676__F10 Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling 595 2885 1398 999 998 6010 4318 286133 6714 PMC2801177__F3 Subnetworks of select putative DEP-regulated gene transcripts show an enrichment of inflammatory response 1356 7852 51764 7498 8303 6093 8451 5627 9306 8490 55970 3845 84539 273 3157 55737 7124 10630 1847 26060 1268 10179 79073 9227 6867 51761 23760 7456 950 959 2059 6370 2926 394 1080 5308 4286 112 59277 55450 1839 55553 5573 PMC2801866__F1 VEGF binding to VEGFR2 on endothelial cells activates its Tyr kinase activity and results in autophosphorylation of the receptor at several cytoplasmic sites 6461 5894 6714 5163 PMC2808458__F2 Toll-like receptor signaling in cell proliferation and survival 4615 2475 3665 3586 PMC2809500__F4 Proteins upregulated during time course analysis in lung or bronchoalveolar lavage fluid (BAL) following intra tracheal instillation of 20 μg carbon nanopaticles (CNP) 3606 1401 325 6346 1435 2243 7066 1906 7450 PMC2812385__F7 Alternative mechanisms exist for the induction of inflammatory and apoptotic genes in the absence of the IFNA/B receptor during influenza virus infection 3164 3621 4193 5371 4609 3663 1958 5610 602 5970 3726 8061 3665 4318 3659 5971 6347 6772 650 3209 3553 4843 4256 837 PMC2814006__F1 IL-1 and TNF signal transduction events 7124 3654 10454 8717 7186 23118 7189 4615 257397 PMC2817383__F4 Putative host signaling pathway induced by Y 4026 4615 9536 3976 80824 6773 6774 578 3098 90865 4284 PMC2819165__F2 Genetic Susceptibility to Lymphoma 7099 4792 3586 3587 7124 3952 3569 6648 595 598 894 PMC2820080__F4 Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE 133 7077 10135 9547 3487 4060 84518 5266 5054 6678 51162 4053 7045 23166 2791 3982 10457 1832 4478 374897 5097 114569 135228 7851 729230 667 5091 2022 3861 1475 2810 7534 3315 63826 6476 23269 2355 30846 342897 4000 10051 1033 PMC2821718__F3 Structure and signalling in the IL-17 receptor superfamily 84818 7189 7187 7939 2932 4615 3661 PMC2822851__F1 Signal transduction pathway from integrin receptors to actin cytoskeleton 1793 998 1398 9564 1794 5879 1399 1795 5880 59 60 3815 9732 5881 72 287 7409 7410 6708 2934 10451 7454 4082 7074 2534 4067 8936 7408 26230 7430 8976 3932 1072 147179 2316 1756 1729 387 7414 2017 388 1730 389 81624 6714 6010 PMC2824905__F2 IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus 8707 8704 8738 23621 5652 331 246329 5465 10410 10559 5283 51604 215 9276 22818 1315 7069 8662 9651 10241 1756 8665 8667 440275 10890 27314 9922 6210 6217 23536 6224 6193 2521 56342 9092 26121 10569 533 348995 10204 1198 9343 10594 57819 23029 3192 23450 57122 57703 6633 191 6634 6208 23521 23451 9716 5546 91746 5125 27304 96764 6729 527 6628 25827 5691 80206 10482 7491 4928 4509 125950 4714 54539 10920 9796 25813 5211 4707 4715 2931 53942 22801 57147 253559 27180 200185 90952 9019 56114 1087 PMC2826542__F1 An Overview of IL-7 Biology and Its Use in Immunotherapy 3716 5728 5163 637 581 2932 PMC2826677__F1 T-cell activation, proximal signalling complex and activation of transcription factors 920 940 3702 5335 3932 5163 7535 2885 27040 8915 10892 5894 PMC2832675__F1 Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement 7124 8772 841 596 581 331 836 PMC2833108__F7 TNFSFR and NFKB signaling activation during macrophage activation: CpG late responses 7124 958 7187 4615 8717 8772 841 7189 7185 842 10454 836 3725 2353 839 840 4513 790 PMC2839263__F2 Emerging models for the role of Beta-arrestin in wingless (from Drosophila) and the oncogene int-1 (WNT) signalling 1499 387 998 4040 4041 4920 6259 PMC2840217__F9 Parkinson's disease (PD)-related gene pathway in response to MG132, methylmercury (MeHg), and cadmium (Cd) in MEF cells 3630 7345 27005 83844 7874 57663 84640 9099 4137 6622 842 6804 8945 5412 135138 836 10425 9627 2861 11065 51271 25820 834 51465 11315 PMC2841320__F6 ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway via Zinc Finger Transcription Factor CREB 5091 6774 595 PMC2842130__F9 Redoxosomal signaling for IL-1B and TNFA pathways 7124 6647 7186 7189 3554 4615 8717 PMC2846061__F3 Ovary: basic biology and clinical implications 374 2069 6714 1956 2492 3623 894 2100 685 1958 5241 5743 3037 5806 4086 6616 5593 860 9510 1514 1907 7130 861 6424 9210 PMC2846156__F3 Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer 7099 4118 695 7189 7187 29110 8772 3661 3665 PMC2847521__F11 Proposed model for the I3C disruption of a cross-regulatory positive feedback loop involving expression of GATA3 and ERA by stimulating the degradation of ERA protein 196 9978 2625 PMC2852400__F7 Inhibition of the Proprotein Convertases Represses the Invasiveness of Human Primary Melanoma Cells with Altered p53, CDKN2A and N-Ras Genes 1029 673 1019 4193 PMC2854141__F9 Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease 3565 7124 1950 183 2520 7040 1440 1435 2064 355 185 1956 4170 2204 5617 6714 3952 3939 23236 207 613 4763 5478 4747 387 596 4741 652 4744 2308 1958 2114 55599 3725 6667 4654 6774 7273 1385 7157 1050 4609 2002 4729 1869 PMC2854308__F1 Signaling complexes induced by TNFA to mediate NFKB activation, apoptosis and necroptosis 1540 8717 7186 8772 PMC2854673__F1 Minimally oxidized LDL induces TLR4-dependent lipoprotein uptake by macrophages 7099 929 7409 6850 6010 998 PMC2862867__F4 Sites of action of curcumin on cancer cells 1956 9429 7412 596 4513 PMC2864663__F5 Aging-related upregulation of NFKB signaling in VSMC 5971 3383 7412 PMC2869512__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis 7018 3606 1401 4513 7412 3383 PMC2871634__F4 WNT/Beta-catenin signaling pathway 2487 2932 10023 324 1499 595 PMC2871634__F5 Regulation of apoptosis 355 8717 8772 1616 637 7186 5062 5058 790 PMC2871659__F1 Overall scheme of key genetic and epigenetic events in colorectal tumorigenesis 4513 324 1499 673 581 4292 PMC2879972__F4 Illustration of different mechanisms of MUC1 and MUC4 for the repression of apoptosis 4585 4582 2261 2064 8772 PMC2881280__F1 Schematic representation of the proposed enzymatic steps in the FAC -elicited JA biosynthesis pathway regulated by SIPK, WIPK and NPR1 4881 2717 4015 PMC2882122__F4 Selection of expression patterns and activities of members of the cadherin superfamily in cancer 1012 8642 79633 2821 1008 999 83259 1000 324 1003 367 PMC2883240__F1 Signaling pathways involving molecular markers for human breast cancer 2353 3725 545 472 1758 595 6909 6926 1019 4193 675 672 5111 1719 PMC2887259__F5 Signaling cascades that regulate A 3479 3667 9846 7432 624 2932 759 847 7186 2534 2002 6571 PMC2887830__F2 Regulation of intracellular Stat3 signalling 9021 6774 4313 4318 3383 595 3091 2247 3569 3589 7291 6387 3586 4513 PMC2888582__F6 Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction 49 387 7448 2782 23011 2787 3673 1808 3339 10627 59 1073 7431 1956 7412 1499 1969 3091 7419 81839 301 7529 3728 595 350 7169 4087 2661 239 4043 3689 928 7170 81 7037 811 64841 10096 718 3482 3685 10631 5646 10134 5411 283571 PMC2889604__F7 The regulation of neuronal migration and neurite outgrowth by the MRTF/Srf pathway 6010 6722 5058 1020 PMC2899674__F1 Molecular pathway for arterial, venous and lymphatic cell fate determination in vertebrate embryo 2050 2296 54345 83595 23462 5629 PMC2901320__F5 CXCR4 pathway is affected in CD34+ cells from CAD patients 7852 2534 3717 1398 7409 5879 3265 6010 2002 6774 PMC2906469__F3 Progressive inactivation of GSK3B may promote increased anti-apoptosis and oral cancer 8772 2932 596 581 PMC2911501__F3 PTEN-regulated signaling pathway 5163 5728 572 581 7248 7249 2475 1977 PMC2913069__F1 Interconnected pathways that cause bone marrow failure 10993 6125 6135 6165 54433 55651 6231 55505 1736 6204 7012 7015 6201 6229 6218 54984 2188 2175 2189 2187 2176 55120 2178 57697 1200 26277 25913 472 545 5888 7013 7014 54386 55215 2177 PMC2923187__F8 Hybrid Models Identified a 12-Gene Signature for Lung Cancer Prognosis and Chemoresponse Prediction 6352 3458 3553 3479 3630 7124 3611 351 5170 9114 1994 6609 8428 207 10541 5395 8125 5903 7514 1956 3845 10395 5313 7157 1874 1875 PMC2923453__F1 Molecular Pathways: Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma 4613 4609 51582 4946 4947 51686 262 196743 6723 6303 4513 6611 54498 PMC2924816__F1 Quantification of Beta-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry 999 1499 847 324 8312 1457 2932 595 960 8313 4316 PMC2926987__F3 Reconstructed antioxidant regulation pathway of detoxifying proteins 5599 9817 4780 5594 1432 1385 23764 468 4097 2353 7975 3725 7018 2052 847 2729 1429 5447 2939 6647 PMC2927952__F3 Insulin signaling pathway from PathVisio 3630 3643 3667 5590 207 5584 6720 5562 5563 5571 5106 2203 5214 2194 31 32 PMC2928401__F8 Identification of Primary Gene Targets of TFAP2C in Hormone Responsive Breast Carcinoma Cells 1382 65057 949 8648 5618 3320 85451 8202 121340 4522 1604 80781 2099 2050 4609 23077 1312 4088 8626 6464 3488 8553 685 2059 PMC2930673__F1 Cellular iron processing 7018 22 23456 2242 5093 PMC2935989__F2 GRK2 interactome involved in cell migration 1233 1234 7097 7098 51284 7099 7852 3667 5898 4087 4088 5997 5999 28964 156 324 2885 207 6714 4193 5074 3760 PMC2938097__F6 TNF/Fas/TRAIL signaling pathway 355 7124 8741 3313 7186 8738 1616 9191 1613 8767 51564 11124 23197 PMC2939609__F3 Molecular interactomes and sub-networks associated with tumor cell susceptibility to arsenic trioxide 2317 22823 2736 1488 9314 7410 3151 7296 267 8996 2886 3925 2539 3397 7164 4678 9170 5468 51177 10553 1871 3664 3428 8289 196528 6382 4488 3918 PMC2939656__F4 Complement/Coagulation pathway activation 2149 2152 1361 2155 2159 2147 2153 2160 2158 2157 7450 7056 5624 5627 2 5327 5328 5329 2161 5340 3818 966 729 730 735 717 721 719 720 1380 1378 PMC2943488__F1 Schematic of the drug- and cytokine-induced hepatocellular death signaling network, curated from literature references-, - 7124 3630 2885 8717 7297 3654 4615 3667 7186 7189 8772 6778 6774 637 581 839 2475 572 331 836 842 85451 PMC2943859__F9 TNF-R1 signaling pathways 8717 7186 8772 7185 331 4616 PMC2944809__F5 Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence 7099 29110 7124 7186 3717 6774 5606 6722 2 PMC2945950__F6 Triangulated graph Dt obtained from BCR pathway 933 6850 971 4067 29760 695 5336 2885 25780 8915 975 2932 930 PMC2948275__F1 Putative functions of caspase-2 545 472 983 891 637 581 PMC2949081__F1 Summary of the RAS incorporating the Ang peptide family and physiological effects mediated via ATR subtypes 59272 1636 258 545 PMC2949778__F1 Folate metabolic pathway 5981 875 4552 4548 4524 2618 7298 PMC2951022__F1 Toll-like receptor (TLR) signaling pathways 54472 3654 7189 51295 29110 23118 10454 5970 3661 929 7099 114609 4615 7100 7097 7096 10333 PMC2953915__F7 Model of E2F2-mediated regulation of the Ahr pathway 1870 196 405 9049 57491 22909 PMC2954189__F1 Simplified scheme of the double-edged role of Akt in tumor development 1017 2475 4193 572 842 7249 PMC2955618__F6 Runx2-regulated cancer-related gene network 4885 1907 1437 9518 7035 84171 8530 5654 3700 7057 3934 7422 3562 4322 6462 5225 8743 25805 7804 116443 6768 30061 3732 4071 9123 79679 214 2706 55646 1740 43 5734 1755 10461 5742 6590 65985 5580 10763 80176 2634 7052 8877 5366 1047 2052 25803 2146 51053 4609 1870 4824 580 6502 83879 5427 467 6591 7443 28996 29893 10217 10140 1050 9935 5997 990 4091 4088 7025 412 864 861 4501 51092 860 PMC2965188__F2 Nrf2 cytoprotective signaling pathway 9817 4094 9978 PMC2970576__F5 Analysis of gene expression in CD44+/CD24− MCF-7/ADR cell population by TaqMan Low-Density Array and Ingenuity Pathway analysis 356 355 154 301 6714 598 2633 578 1786 27043 7157 3930 4193 5886 196 3297 1050 2100 5591 7518 3981 7124 4318 3551 10808 3315 4791 3725 1052 7490 2033 8626 4149 4609 6934 1019 898 4088 3398 4683 7528 5423 PMC2972203__F8 Reverse-Phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells 3667 331 572 637 6774 2002 6772 PMC2974215__F2 TNF-dependent signalling pathways mediated through TNFR1 and TNFR2 7124 7186 8772 8717 PMC2975490__F1 Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis 4040 4041 4920 6010 324 1499 51701 PMC2983445__F2 Growth factor signaling pathways mediating proliferation in multipotential stromal cells 1950 7474 7043 89780 3082 650 1956 4087 4088 324 4089 2002 1499 595 PMC2988681__F2 Programming anoikis induction 355 8772 6714 2932 PMC2992472__F4 The regulatory network of apoptosis in BCL11B and its related genes 64919 8743 598 6696 1387 581 8772 PMC2992967__F2 Sonic hedgehog (SHH) pathway 6469 6608 5727 51684 2737 2736 25805 4609 3485 3280 6423 6422 PMC2994033__F1 Signaling complexes are induced by TNFA to mediate NFKB activation, apoptosis, and necroptosis 1540 7186 8717 8772 PMC2997002__F3 MAPK signaling pathways generated by GenMAPP 8517 4137 627 5581 5583 673 2002 3845 6722 6655 5901 2780 5880 5062 3727 7939 26136 835 5580 2645 6418 929 PMC2997007__F5 Candidate master switch molecules and signaling pathways involved in LPS-induced inflammatory response of monocyte THP-1 cells 5970 6667 1386 4286 3553 3676 6772 3383 3690 929 1003 7412 4254 4842 3586 3595 999 6403 2113 3673 1499 6850 4982 1958 5008 8794 1234 596 6401 8795 PMC2997007__F6 Identification of putative signaling regulators for immune-modification 5886 6772 6667 596 6403 4254 4804 5970 7528 7852 8794 999 3673 4353 4982 PMC2999296__F2 Toll-like recepter 4 signaling pathway modified from Wikipedia Commons 3929 7099 929 7189 3654 29110 51135 4615 114609 PMC3000682__F7 Pro-inflammatory pathway induction by cAMP/PKA signaling in BSC-derived lesions 2113 3553 4513 PMC3000836__F1 Comparison of the DC-ATLAS Toll Like Receptor (TLR) 3 pathway with other pathway databases 3569 5177 10278 929 23118 100187907 9081 958 978 7124 114609 51135 9317 6886 PMC3001241__F2 Toll-like receptor signaling pathways containing P 7097 5879 10333 54472 114609 8772 841 339855 3929 4615 929 10454 23118 51135 7099 7189 958 941 3663 942 54106 3661 7098 7187 PMC3005023__F1 Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis 284 2248 5228 7422 9978 8453 3098 2597 3939 5230 5315 5211 7428 2056 133 3481 3484 7039 4851 4843 6929 7291 4015 1509 442917 9839 6935 8788 3569 51129 1843 7852 PMC3006139__F6 Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse 7099 114609 51284 7098 4615 51135 3654 10010 3665 4794 PMC3011108__F1 Schematic showing that when a cell membrane is injured the arachidonic acid pathway is activated to initiate the local inflammatory response through the production of prostaglandins, thromboxanes, and leukotrienes 4015 4512 5228 PMC3012182__F1 TRPM channels in insulin secretion 29850 54795 80036 7226 PMC3018096__F1 Adapters in the organization of mast cell signaling 2885 2534 9846 7462 PMC3019079__F1 The homocysteine and folate metabolic pathway 5981 4548 4552 875 4524 PMC3021862__F4 Genes regulated by Survivin in ITD-Flt3+KSL cells and deregulated in LSC are mapped on functional signaling network associated with epidermal growth factor receptor signaling pathway 56907 3600 2798 7450 2776 387 2268 6714 1956 2885 998 6788 5894 1390 2114 1432 PMC3022823__F7 FBPA clustering on gene expression after direct irradiation 467 2078 6672 10765 3066 10370 4609 4089 10950 22943 55509 6875 1869 7161 5371 2309 3661 4851 2114 2113 2034 3659 3725 3660 1602 5966 4513 5970 5055 4665 668 1958 64332 1051 4223 54627 2921 2920 4794 650 2000 10365 5971 196 55922 PMC3023029__F2 Intracellular transport pathway of Shiga toxin 6850 998 6643 6642 57584 29886 30845 400 9341 143187 5870 10652 83452 339122 PMC3025434__F1 Simplified overview of the pathways involved in miRNA regulation of gene expression in addiction 627 2475 1386 6775 27161 29102 54910 5328 8828 5999 8864 PMC3030591__F4 Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte 3551 140738 5566 4137 5801 5778 5582 5590 11221 5924 8399 5906 5583 468 673 3845 2002 6722 2353 1950 3265 22808 5605 5533 5530 5532 2249 4342 4609 5155 5159 5921 2768 5535 1399 409 4094 3725 5880 5058 5062 1386 835 5494 207 208 10000 836 7124 5581 2645 3552 3553 356 1616 5608 7046 7048 4208 7042 3316 9261 4216 9344 51701 5598 PMC3030971__F1 Key proteins and pathways in the replication stress response network 545 5884 3014 11073 54962 472 54617 641 29940 4361 5893 5888 PMC3035360__F1 Synthetic view of the p53 pathway 4609 1869 5371 3400 10769 5300 4193 581 PMC3035754__F1 Regulatory network governing mitochondrial functions orchestrated by PGC-1A 7428 5465 23411 PMC3035969__F5 Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression 5971 4908 6722 22808 2885 4342 4609 4763 55970 3725 7374 5881 7186 355 1616 4149 7046 920 51295 51701 PMC3039931__F3 Inhibitory pathways in innate cells utilizing ITIM or “inhibitory” ITAM signaling pathways 140885 6850 6010 4678 7006 100124696 PMC3040416__F3 Proteins oxidized by extracellular EhCySS control cell signaling and morphology 529 4627 6526 1937 6124 6217 1915 6218 6191 4641 481 6135 183 10631 1778 6389 4719 6711 4133 10970 7415 PMC3042129__F8 Unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening 23576 6317 5111 10213 4326 2150 3858 5265 5983 4000 4171 5925 7531 1062 7153 1915 60 302 301 2023 9493 836 5885 PMC3044438__F3 Identifying genomic and developmental causes of adverse drug reactions in children 9429 2346 10257 135 84890 2356 8836 5471 2618 471 1719 81034 25902 4522 4552 635 4548 23743 10797 6472 6470 10768 4524 7298 PMC3046063__F7 Proposed working model and protein–protein interaction map 2475 81565 27185 2770 2771 387755 56992 1956 1062 2773 7517 5594 4131 4077 1612 64422 23192 23001 7157 5728 10287 10533 9474 83734 142 5266 596 7249 581 578 7405 PMC3046639__F1 RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it 867 3265 1431 3845 6654 4763 2885 5894 673 161742 8036 PMC3047110__F6 Proposed model for ERG functions in prostaglandin signaling pathway 4513 4512 717 2078 3248 PMC3047474__F2 Innate IgA-inducing signaling pathways 7939 4615 3654 51135 7189 7186 864 57379 PMC3047627__F3 RECK pathway in stromal–epithelial interaction in prostate cancer 7077 7076 7078 7079 100187761 4314 4318 4312 4313 4323 8434 3265 PMC3047785__F5 CD28 signaling events 940 5163 2475 3932 572 2885 5879 7409 998 2316 PMC3048826__F12 Signaling pathway of HMGB1-mediated ischemia reperfusion injury 3146 54106 6714 6010 3383 998 5879 7124 3586 PMC3048826__F9 Hsp72 is an important intracellular protein to inhibition of HMGB1 release and proinflammatory function in macrophages () 3146 3603 8177 PMC3050939__F3 Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis 3157 3156 4598 10654 4597 3422 3652 2224 9453 2222 1717 5876 5229 PMC3051378__F5 Resulting endoplasmic reticulum (ER) stress and unfolded protein response (UPR) gene network from a modelling approach using the set of differentially regulated genes common to all pancreatic cancer cell lines after nemorosone treatment 7832 8061 1958 3725 2877 3309 2950 3162 22926 4170 440 10018 595 1027 1019 578 836 PMC3056141__F1 DNA-mediated activation of innate immune signaling 9447 8772 7187 3596 29110 3661 PMC3057165__F1 Pathways by which toll-like-receptor signals and ligation of FcG receptor lead to the production of interleukin 4615 6850 7189 PMC3059752__F3 Knowledge-based pathway analysis (Genomatix BiblioSphere Software) indicating the network of high BMI-associated genes 3638 6659 58480 4094 290 182 118429 10278 2810 23024 PMC3060320__F2 Schematic illustration of signalling within the type I interferon (IFN) system 2833 7852 7292 3455 7099 8829 7297 114609 7098 5132 51311 64135 81030 6773 6774 54106 7187 8717 6885 8767 4615 8772 10010 51284 6696 9063 8554 10401 51588 64343 9755 8651 9021 3665 7128 3659 3394 3551 3660 9641 3661 3662 10379 8600 3467 3447 3452 3440 3444 3443 3442 3445 3448 3451 3446 3449 3441 56832 608 8741 115650 PMC3060875__F3 Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses 6667 2353 3725 6354 6364 PMC3061395__F10 The bifurcating parallel signal transduction pathways downstream of the IL-13R that regulate 15-LO gene expression in primary human monocytes 3597 7297 3717 6774 1958 PMC3061960__F5 NFKB activation in B cells 613 7099 3654 8915 51135 84433 10892 5970 PMC3062410__F2 Networks most highly represented by transcripts differentially associated with HuR after IR treatment 1956 5899 1950 4763 2316 3725 2002 7124 7186 8195 355 4149 920 847 51295 2208 100 60 7314 3706 PMC3062664__F1 Metabolic insulin signaling pathway genes genotyped in the discovery cohort 5728 3667 8660 867 5163 207 10023 2534 PMC3063194__F2 Evasion of immune responses by individual EBV products 355 51284 6373 8772 10379 3662 3665 3663 836 3586 3661 920 7874 PMC3064890__F4 BRCA2/RAD51 pathway in response to DSBs 545 56946 3240 675 472 84126 PMC3068086__F4 Coordinately up-regulated TCA cycle genes in CD8+ T cells from the VIR group (VIR versus LTNP) illustrated in TCA cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) 5106 4191 4190 47 3418 3421 6391 4967 161823 8801 PMC3068086__F6 Branches of MAPK pathway significantly enriched in CD4+ T cells from the LTNP group (BDL versus LTNP) 998 3265 2885 5609 5606 5601 4775 4792 3725 1387 2353 920 PMC3070553__F11 Signaling modules identified by correlational analysis of end points 1003 1956 2064 1499 6714 2549 4087 6774 10401 572 2931 2932 5728 4082 PMC3071786__F6 Changes in mRNA levels among various signalling pathway members following inhibition of FGFR activity 2248 2239 6591 55869 2249 200734 8320 467 7547 8817 10818 7494 468 2885 1046 2004 1848 10252 10251 10253 5156 9496 10000 6911 5453 147111 6423 324 7473 1499 8322 8324 8325 11211 387 1387 22938 1910 PMC3071979__F2 Inhibition of NFKB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice 650 652 1950 4049 351 4179 114609 4615 7186 3932 7535 5336 7335 10454 6476 5970 3065 3066 4026 9118 PMC3078503__F4 PIKKs and TCR-associated pathways 84126 4193 472 545 1869 3014 581 672 PMC3089921__F1 mTOR activation supports cancer cell survival 2475 595 27040 PMC3091668__F5 Putative TCR signal pathway 940 1493 2534 7535 1445 3932 2885 3702 5894 998 8915 10892 3550 6722 2002 1386 27040 920 PMC3091682__F2 Correlation of Predicted miRNA Targets with Hosts 842 5925 572 1017 5728 2308 5154 5163 4193 5604 2885 3550 2475 367 6716 PMC3094730__F2 Dendritic cell control of tolerogenic responses 999 7097 10333 8651 9021 50943 PMC3097097__F2 Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term 4312 112744 84818 7189 3716 3383 3717 847 1431 6667 6354 PMC3101816__F1 The central role of cIAP1 in NFKB signalling and programmed cell death 8717 7186 10486 8772 PMC3103347__F5 Effect of SCGB3A2 on TGFB signaling pathway 7049 3624 10468 9241 2022 7048 6696 860 25805 864 4086 4087 4090 4088 7481 6774 3976 7124 3725 8928 3458 652 1387 1950 51083 6498 2353 6497 PMC3103499__F3 Computational Identification of Transcriptional Regulators in Human Endotoxemia 7593 3553 4190 4191 5162 7124 8794 11213 1441 6955 3419 6364 355 47 8837 843 3625 2739 2920 PMC3103528__F5 Inhibitory Actions of Anti-Müllerian Hormone (AMH) on Ovarian Primordial Follicle Assembly 4089 651 3458 7124 4919 7057 6500 6667 1616 387 4838 PMC3104011__F2 miRNAs regulate DSB DDR through modulating the core protein components of various pathways 4361 165918 9656 672 10111 545 355 574507 983 4193 581 1017 5890 7518 993 3981 5889 5888 675 995 5347 PMC3104248__F3 Signaling molecules implicated in epilepsy (see the text for the detail) 572 5292 637 1975 7249 7248 5310 4193 1017 27250 6009 2308 983 595 3667 PMC3104565__F1 Simplified diagrams for agrin-induced signaling 4038 285489 4593 5609 2534 PMC3104927__F6 RHIM-dependent signaling 7099 7098 29110 3661 5970 PMC3108467__F4 IFN signaling pathway coded with identified proteins on day 7 postinfection 3458 8554 10379 581 3430 3659 684 2633 1890 10606 PMC3109860__F4 CHK1 Inhibitors in Combination Chemotherapy 142 472 545 581 6714 PMC3110099__F14 Schematic diagram to show that knockdown of Akt1 leads to upregulation of Akt2 in response to oxidative stress and its regulation of oxidative-stress-induced apoptosis through three pathways 207 208 2932 4193 PMC3116400__F1 DSBs in S and G2 phases of the cell cycle, collapsed replication forks, and daughter-strand gaps all require HR for their repair 10111 4361 5888 672 79728 675 PMC3117391__F3 Pathway for getifinib and docetaxel to generate the synergistic effects on KRT8 3265 1956 2261 22800 6654 5747 3716 5566 5879 5580 5595 663 5594 5894 836 596 6714 3717 1432 9021 6774 3725 7157 5300 PMC3118679__F6 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 15 relative to −15 d postpartum 3643 6513 6247 3717 23395 7248 3906 7249 6009 1938 1432 2475 29904 10682 1999 6194 1977 6124 6146 9349 PMC3118679__F7 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 60 relative to −15 d postpartum 3643 6247 6505 5163 3717 2931 23395 7157 7248 7249 3906 1448 6009 1938 1432 5289 29904 1999 6194 1977 6124 8178 6146 9349 PMC3119514__F2 TNFA and TCR activation pathways 3932 7535 5335 7188 7186 8772 64170 29775 79092 8915 10892 7189 23118 10454 8717 PMC3123876__F6 Profiling experiments and pathway analysis 717 6420 26298 9969 5469 203068 9705 5644 10913 5645 PMC3126020__F1 Hedgehog signaling pathway in vertebrates 6608 5727 2735 2736 2737 51684 PMC312710__F8 RegA regulation by differential degradation 59330 7316 6500 PMC3127162__F8 E3 ubiquitin ligase-dependent and E3 ligase-independent roles of Rad18 in tolerance of bulky DNA lesions (left) and replication-associated DSB (right) 7150 56852 353497 5889 2177 PMC3128904__F1 Toll-like receptor (TLR) signaling pathway 7099 7100 7096 7097 10333 4615 114609 7098 51284 51311 54106 7189 7187 51135 29110 3665 3661 PMC3131208__F2 Cellular targets of the Tax viral oncoprotein 1021 1019 6722 1739 5423 5902 PMC3131208__F4 NFKB signaling pathways 613 4055 958 7187 7186 8915 7189 23118 10454 5971 5970 PMC3131688__F1 Autophagy in immunity and inflammation 466 5066 55054 10392 64127 81671 4615 1611 3146 958 4179 3976 23529 3565 6387 596 6774 4077 2475 64422 PMC3133232__F8 Schematic model of Nrf2 regulation by Keap1 9817 9978 8452 4094 PMC3135641__F1 Metabolic target genes of p53 2593 847 57103 2876 27244 83667 27165 9997 PMC3136563__F12 Working model for the role of USP4 in the negative regulation of TNFAlpha-induced TAK1 polyubiquitnation and NFKB activation 7124 1540 27005 9958 8237 8717 7186 7188 23118 257397 10454 7375 3550 5970 5966 PMC3137930__F8 Analysis of p53 target genes in melanocytes treated with Nutlin-3 for 18 h 5111 5728 9997 4193 57103 64065 581 2765 26155 3399 55388 4851 7083 6878 7071 1017 8609 51514 10951 2305 5292 8451 83461 4791 6749 PMC3141878__F1 TLR4 signaling cascade and evidence for modulation by neuropathic pain and opioids 7099 929 4615 114609 51135 23118 257397 PMC3142070__F4 Cause and metabolic consequences of fatty liver 84649 79071 5465 338 6462 PMC3145607__F5 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G1-enriched MCF7 cell cultures 4824 3875 468 56475 642 55023 5311 5764 1008 3217 2263 2258 5734 285 9466 4664 1958 2778 152559 3725 10125 3925 4638 920 5074 PMC3145607__F6 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in S-enriched MCF-7 cell cultures 6286 4133 7832 467 3725 2778 57630 11214 144455 8502 478 1501 23037 6310 10950 23764 54578 2729 4780 3635 2657 2512 93663 48 126328 PMC3145607__F7 Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G2/M-enriched MCF-7 cell cultures 1738 114880 1960 323 5160 4683 26053 5578 1339 5581 581 10628 3094 4209 23019 84674 405 2944 4780 11080 4189 3297 5241 57630 1311 81928 49855 6513 147463 3093 7341 4869 132158 7157 10200 4255 PMC3146975__F1 Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 6850 6461 1435 2534 27040 2885 6714 8036 23164 5481 1390 3726 PMC3146975__F3 Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 7852 3747 783 5998 4493 998 389 2358 9901 5063 150 8484 2770 23164 5339 466 8626 64375 10320 2773 PMC3148569__F6 Perturbed TGFB/Smad and mitogen-activated protein kinase signalling pathways in Dupuytren's fibroblasts 654 4838 4087 4088 4089 1278 PMC3153165__F1 Roles of the NFKB-mediated inflammatory pathway in cellular transformation and in cancer cell survival, proliferation, invasion, angiogenesis, and metastasis 331 595 7124 4513 4318 3383 7852 7412 PMC3154190__F5 Characterization of the MDSC Proteome Associated with Metastatic Murine Mammary Tumors Using Label-Free Mass Spectrometry and Shotgun Proteomics 7057 1508 60 1475 4069 3934 2185 308 388 1786 2811 2814 5473 5196 7450 1601 23607 246 348 824 5921 290 383 7052 1385 3092 6844 9221 1523 3106 3107 1211 PMC3157269__F3 Sensing the HP-PRRSV infection by host cell 3665 8651 3661 23098 526 22904 51311 51284 4615 7098 9111 6772 3466 PMC3163944__F7 Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice 5613 4915 4914 6722 1950 1956 5605 2885 2002 9846 8036 1844 84867 2768 5922 3925 2316 3727 1386 7124 2005 355 1649 1616 4149 4208 929 PMC3164721__F1 Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome 3845 324 7157 5290 5728 673 581 4292 2885 6010 207 8456 PMC3165779__F3 Cellular PA-interaction networks 4670 23039 3842 5901 11260 3838 1434 23534 10527 7514 51194 81892 7127 4641 9688 24148 8813 1410 4905 51144 2040 9391 6513 31 64210 9894 2194 27175 7965 9276 1314 5591 6772 1500 1956 8402 26958 1937 8729 81876 1778 6416 55750 10945 PMC3166203__F10 Different ways to activate NFKB 4615 51135 3654 7189 6850 5971 114609 7186 8717 7188 PMC3167094__F1 New Hormonal Therapies for Castration Resistant Prostate Cancer 412 3293 8644 3294 6715 1646 1645 3028 7366 PMC317355__F3 Wnt-signaling pathway 324 2932 1499 7008 4040 4041 PMC3174208__F1 Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke 1719 4143 6573 262 2348 6470 6472 7298 4522 6947 10797 635 6948 4837 4548 4552 55349 4524 191 5444 875 1491 PMC3175442__F4 Map of cytoskeleton remodeling pathway (Genego Metacore, fragment) overlapped with quantile-normalized estimations of protein abundance 3611 847 2885 2932 1499 3265 3985 3984 5594 PMC3175721__F6 Models for context-dependent ICL repair during replication 51804 80198 22909 PMC3179548__F2 PE intoxication pathway 5045 4035 53353 933 1938 PMC3180262__F8 Hypothetical molecular signaling pathways of the expression of p27 by which moderate increase in the concentration of D-(+)-glucose down-regulates and deficiency of D-(+)-glucose or L-leucine up-regulates the expression of p27 7249 7248 23410 29904 PMC3180440__F3 Regulation of the late myogenic transcriptional program by the kinome 1000 5163 208 5164 2475 1025 4775 1499 PMC3181439__F1 Jun N-terminal kinase signaling pathway 1616 7186 2645 993 207 581 1386 351 3297 6774 3831 142679 PMC3184251__F1 Smac mimetics and TNFA: a dangerous liaison? 7124 7186 8717 8772 PMC3186862__F1 BAD pathway in genes associated with induced cisplatin-resistance 3479 1956 5170 3667 847 2885 5603 572 3265 983 PMC3191732__F1 Cyclooxygenase pathway of AA metabolism 4512 5226 5228 1690 4049 PMC3193409__F4 Expanding role of ubiquitination in protein kinase activation in diverse NFKB pathways 920 7706 7186 57506 10454 8915 10892 7189 7187 29110 472 23118 257397 3661 PMC3193452__F1 Regulated necrosis in the intestine of FADDIEC-KO mice 7124 4615 8772 1540 3553 PMC3197649__F3 Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes 54205 9533 3838 8575 51434 26271 60598 4830 10987 84612 4683 9232 655 11200 641 991 10153 29028 8202 823 112858 27283 1869 50484 7013 5159 4747 995 890 81620 7431 595 3428 11244 8894 5771 7534 22882 5591 4605 2167 1017 5747 2305 9842 9134 4173 5500 9055 6714 22919 9133 1281 332 5770 55824 9046 4171 9212 9493 3055 55143 9844 1058 PMC3197649__F6 Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes 8737 7188 860 58190 891 682 8428 5757 7704 840 10277 161 55729 55041 5311 857 8647 79444 10006 10456 9764 2060 6617 9900 161742 3815 8976 3801 3717 5336 55755 7010 119587 5786 5802 5925 1788 4747 2185 27043 2048 10951 1107 10989 1652 3420 2253 8789 2263 388324 4093 8900 4331 2043 3276 9640 6383 7049 7161 22938 399 51741 5272 65080 55898 5934 PMC3198763__F2 MTORC1 pathway controls cellular metabolism 3099 3098 5214 226 2597 7167 5236 55276 2023 5226 55326 284161 6888 7086 9415 4598 51144 3156 2181 3157 47 2194 6576 2744 5163 PMC3202302__F4 Signaling by the TNFR superfamily in B-cell biology and disease 930 5266 5728 7187 6850 7186 29760 695 5336 5163 10892 2932 5971 572 412 2308 108348016 PMC3203325__F2 XPC: Implications in cancer and oxidative DNA damage 7508 1643 5426 51426 5111 7515 3980 2067 PMC3203674__F1 Coronin 2A-dependent LXR transrepression pathway in macrophages 7099 8841 3725 26168 7097 PMC321458__F8 Model of the role of RNase MRP in cell cycle control 54464 10518 324 PMC3219404__F1 Putative involvement of the receptor for advanced glycation endproducts (RAGE) during infection 3146 6283 7412 3383 PMC3224542__F1 Genes related with the tau protein phosphatase-2A (PP2A) pathway 5300 8125 51451 5515 5520 51400 PMC3228973__F4 Proposed signal transduction pathways in nodose ganglia following receptor activation with leptin and cholecystokinin-8 (CCK-8) 886 3717 6714 387 PMC3230808__F7 Regulation of CYP1A1 by capsaicin in Hepa-1c1c7 cells 7442 8532 196 10682 405 1543 PMC3233269__F1 PA can be generated de novo,, by sequential enzyme-catalyzed acylations of glycerol-3-phosphate, or in response to cell signaling pathways () 95 5728 5091 5337 4018 4026 2475 PMC3236216__F8 Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways 3557 3458 942 3958 3606 8743 8741 5795 1234 19 1536 6386 5878 653361 929 4689 8301 1824 837 51060 4615 64332 6648 51479 4599 7296 9021 1520 64422 1675 5870 199 3937 9019 528 2185 4170 8660 4069 1647 1051 6688 7409 7130 2120 10062 5970 2242 4005 6391 688 10379 467 1052 3661 2114 PMC3242363__F5 The mechanism of late PC 3716 3717 6714 3932 6774 6772 PMC3245506__F1 Network of differentially expressed genes in HMGA1 transgenics at 2 months (nonparametric CAM approach) 79577 6489 8530 8320 5583 3159 5657 5925 51744 1991 1992 3001 1511 9437 1656 4151 604 4353 1879 PMC3245506__F2 Network of differentially expressed genes in HMGA1 transgenics at 2 months (parametric approach) 2258 637 2002 5551 351 3858 85451 5583 3497 3159 941 5664 3399 3638 9437 3683 3659 4049 3559 8320 PMC3245506__F3 Network of differentially expressed genes in transgenics at 2 months (parametric and nonparametric approaches) 27086 5664 84824 7186 2002 351 3004 960 8320 1601 941 9437 9077 1386 3159 4049 3156 8809 3497 3559 2833 4149 2690 3659 9788 5583 567 PMC3245506__F4 Network of differentially expressed genes in HMGA1 transgenics at 12 months (nonparametric approach) 7035 7296 8809 3161 2571 22974 222643 9705 3839 3836 3159 4151 23308 6489 921 5142 3683 10125 3586 4345 10971 3112 10148 PMC3245506__F5 Network of differentially expressed genes in HMGA1 transgenics at 12 months (parametric approach) 8863 10615 8899 5058 3159 2869 4151 900 4194 23049 4751 3654 340451 6533 367 3985 9521 55872 2237 7157 10521 9015 7337 6651 901 23397 29979 4437 PMC3248149__F3 Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence 4193 5728 7249 7248 2620 6009 6194 1977 PMC3248170__F1 Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers 3845 5159 3480 673 369 PMC3249608__F2 RA-dependent non-transcriptional involvement in neurite outgrowth 5163 5164 5879 5728 572 581 2475 PMC3251560__F7 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes 4288 50650 8805 79980 6097 78994 3619 3172 1158 6095 51347 7110 54558 6774 2241 669 3953 79602 23509 PMC3253010__F3 A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype 6678 3910 22795 4811 22918 3339 3745 58494 2534 858 857 23129 3791 8829 3384 10580 10000 397 PMC3255319__F1 Oncogenic and tumor suppressor control of metabolism 5728 4763 2271 5209 3939 5163 3417 3418 177 5620 2475 7428 26227 3099 2539 2194 47 PMC3257565__F2 HSC cell cycle entry is regulated by a complex network of cell-intrinsic and cell-extrinsic factors 7173 3280 3726 648 5728 7249 7248 2475 1019 1021 1017 PMC3260518__F1 Invisible hand: regulation of RHO GTPases by RHOGDIs 6010 57154 998 9986 23463 PMC3260921__F2 Integrin signalling pathway 10494 11235 889 8428 1003 387 PMC3262193__F3 Signaling pathways and proteins that increase or decrease STAT5 signaling in normal mammary epithelial cells 5617 2001 3717 1950 2066 7039 207 5058 PMC3262331__F2 Schematic signaling pathway mediated by the L-CBM complex in T and B lymphocytes.Notes: The L-CBM complex acts in the canonical NFKB (p65/p50, cRel/p50) activation pathway mediated by IKKB downstream of TCRs and BCRs 7099 4615 613 8915 10892 7189 5971 108348016 PMC3270444__F5 Putative inhibitory pathway of LPS-activated inflammatory signaling responses by peptide K5 7099 7189 4615 29110 6714 6850 3661 2353 PMC3271076__F8 Novel YY1-miR-1 Regulatory Circuit in Skeletal Myogenesis Revealed by Genome-Wide Prediction of YY1-miRNA Network 7528 5081 9759 9464 7402 5422 894 998 6722 387 PMC3271661__F3 Summary of Kit/Kitl signaling during spermatogenesis 3815 6658 255877 373863 652 2492 1618 PMC3271860__F3 IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS 79083 27314 55553 2054 8825 22895 9839 8573 100133941 213 23179 286262 54504 3848 5569 9146 10129 6237 4067 3265 1832 2534 10451 60 3606 288 3398 7314 3611 4619 3702 9704 5318 5925 399 144455 3064 56925 5480 1363 6498 391 5166 100506658 5621 23089 5069 5340 2335 144165 1511 4040 8092 4036 4922 182 3479 4224 1514 10468 8862 3075 5806 6590 PMC3272705__F1 Subcellular itineraries of paradigmatic substrates of ubiquitin-dependent sorting pathways 9099 1956 867 5008 23163 PMC3275361__F3 Signaling and cross talk of the PTH and Wnt signaling pathways in osteocytes 5741 22943 847 89780 4041 4040 8313 PMC3276511__F2 Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location 6364 6359 6362 6357 6367 9353 6092 6091 1232 6355 6846 5196 6361 56477 6349 6850 6368 6289 58191 2247 6354 1230 920 2833 729230 51192 6366 1233 3689 6360 10563 1524 6347 10850 2826 1237 5329 4684 3932 5879 1499 1236 1235 5594 2534 64221 10928 960 10803 5328 847 1794 5168 5337 3603 3950 5898 3265 5724 PMC3279748__F2 GSK-3 in NMDAR-LTD 836 572 842 581 3717 5898 5899 6774 64837 PMC3286397__F11 Campylobacter jejuni-induced Cdc42 activation 6714 998 6010 1956 PMC3291562__F4 Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells 6517 6513 3643 3630 3265 5894 2885 5290 5295 5296 8503 3667 6464 2887 5291 5293 2888 8660 25759 6236 5879 53358 5294 30849 6654 5286 8471 6655 5880 5288 2549 5289 5594 4214 10746 5595 5170 7248 5596 4215 10110 7249 5597 4216 5598 4217 2931 2932 5599 9064 6885 1326 5601 6009 5602 5600 4293 4294 4296 6300 5603 1432 7786 9175 10211 10580 10487 867 868 5604 5605 9020 5606 11184 6812 1978 6198 6416 5871 6813 23624 2311 6199 1977 5607 8491 6814 1398 2002 5608 9448 23433 6722 5609 11183 6844 1958 50488 2353 8773 11127 3799 4641 3725 5792 5578 6616 5770 375 382 5580 5167 5583 5728 5584 9882 3636 5213 5781 5588 57381 5211 5867 3631 5590 3991 2997 10938 30846 57761 8651 5562 2998 9021 5563 5506 3551 7494 PMC3294063__F1a Molecular Pathways: Beta-adrenergic signaling in cancer 6714 5906 572 6774 2623 3569 4318 5743 6591 3458 3593 PMC3294420__F3 Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links 208 3667 50486 6774 80339 2308 3569 1431 4018 84649 10682 7099 1998 7494 948 914 PMC3295899__F2 Matricellular Protein Thrombospondin-1 Globally Regulates Cardiovascular Function and Responses to Stress via CD47 961 6714 5163 PMC3298845__F1 Wnt/Beta-catenin signaling pathway in liver biology and disease 4040 4041 1499 999 324 PMC3299304__F3 Molecular mechanisms of HGF-c-Met-mediated signaling for inhibiting TLR4-mediated NFKB activation in macrophages 3082 7099 2932 3383 PMC3302314__F2 Left half, signaling via IPS-1 following dsRNA/ssRNA recognition by RIG-I and MDA5 114548 8717 7187 8772 10010 3661 3665 3553 PMC3304012__F3 Landscape of EGFR Signaling Network in Human Cancers: Biology and Therapeutic Response in Relation to Receptor Subcellular Locations 1950 1956 1353 PMC3311998__F6 Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate 1431 3939 3418 3417 PMC3313666__F7 Outline of the mevalonate pathway 6010 998 207 PMC3314616__F2 Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/Hypoacetylation in the Rat Nucleus Accumbens 1392 4282 7124 3606 5741 8742 2 2688 185 9455 2911 2047 4843 3939 4792 5105 5999 2634 5465 6667 1387 8648 1051 3725 2353 1843 10062 1463 3458 3569 5327 10468 4804 7097 2644 3717 9021 51655 8660 330 10912 PMC3314865__F3 Targeting Mutant BRAF in Melanoma: Current Status and Future Development of Combination Therapy Strategies 4893 5728 369 673 23683 2475 5925 PMC3315368__F4 Gene Array Data from CWR22RV1 xenografts treated with PD325901 for three weeks 3925 4803 627 5899 1950 1956 2002 2885 4342 4763 PMC3317271__F1 Simplified scheme of cell death and survival pathways involved in ALF 7124 7186 8772 637 581 6098 PMC3318211__F1 Signaling pathways involved in anthracycline-induced cardiomyocyte injury 2064 581 572 2626 PMC3319453__F2 Insulin, IGF-I and IGF-II binding to IR and IGF-IR 5163 2885 3667 5728 4193 7249 7248 2475 572 1977 355 581 1998 3297 2932 338386 PMC3319771__F2 Convergence of miR-21 target genes and the apoptosis pathway 7124 355 7818 8717 8772 8626 317 5728 57162 581 5465 8125 10252 10253 637 572 4436 2956 7048 PMC3321211__F4 Apoptotic cascade 637 581 54623 842 836 331 PMC3321383__F2 Linking Lipids to Alzheimer’s Disease: Cholesterol and Beyond 351 23621 5337 PMC3321808__F5 Differential regulation of genes in the antigen presentation pathway in neonates and school-age children with septic shock versus age-matched controls 920 3458 811 2923 213 4261 PMC3328216__F1 CCM3 interacts with multiple signaling complexes 6093 9475 387 83605 10494 85451 PMC3334516__F4 TGFB signaling pathway members and potential pathway member LRG1 4088 4087 116844 387 6010 5594 6093 729 PMC3336023__F4 Chronic alcohol exposure alters gene expression in HepG2 cells 1384 468 3725 4094 7415 2512 2495 907 8192 7295 2730 59330 10961 PMC3336066__F2 Double-strand break repair in mammalian cells 472 1763 641 9156 545 84126 5893 5888 672 7518 51199 PMC3337715__F1 Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure 5728 5163 3667 7248 7249 572 596 6009 2475 253260 2000 PMC3339894__F2 Putative molecular mechanisms of Wnt signaling, lipid metabolism, and IL-6 effects on insulin signaling in nonobese PCOS adipose tissue 3667 6774 7038 324 3991 1499 960 3725 PMC3342359__F2 Autophagy induction by TLR stimulation 7099 51284 4615 PMC3343040__F7 Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease 3156 2099 3263 8877 2100 151056 3991 10135 6648 11245 5603 1509 311 3959 7076 53340 4194 2149 216 5159 6387 3109 5569 81 29103 4313 1906 PMC3343650__F5 Three major signaling pathways are altered in prostate cancers 2066 3667 5291 5288 6464 4914 1950 8013 10499 1029 2316 1021 1031 995 367 7043 1027 5925 26136 2115 2078 6502 1586 2796 332 PMC3346964__F1 Four major molecular pathways activated by tyrosine kinase receptor B (TrkB) and IGF-1 receptor (IGF-1R) 3479 627 3480 2885 5894 5163 2475 PMC3348846__F3 Role of Rac1/RhoA balance in endothelial barrier integrity: impact of ROS and NO 5879 998 387 6010 PMC3351101__F2 Regulation of cytoplasmic mRNA decay 1975 27250 9811 1999 4116 1998 1977 26986 8106 PMC3352318__F4 Association of cytoplasmic peptidyl Cys with functional networks according to reduction and oxidation of Cys residues 7846 203068 27347 10808 10575 5230 4641 226 5518 60 307 10574 3939 1213 81 2316 5339 5037 2317 7965 6188 10487 1729 2539 1968 8894 55832 2194 4736 8761 476 3945 4282 301 7534 4072 10971 1933 7533 5478 PMC3352318__F6 Association of nuclear peptidyl Cys with functional networks according to reduction and oxidation of Cys residues 22794 9939 4116 1192 409 3188 57187 11338 10541 10073 3835 6714 6728 7536 220988 10762 10527 3182 7124 3843 5901 11260 7913 29107 30000 8731 4926 29899 23587 4001 10926 3805 5111 1434 5591 100187907 9967 3181 3190 3191 202559 10521 51729 79171 5093 PMC3352318__F7 Association of mitochondrial peptidyl Cys with functional networks according to reduction and oxidation of Cys residues 7384 7381 23788 1892 5091 2885 6472 4257 7040 7422 9641 4056 7124 7284 6391 6389 6390 56902 3418 3832 376497 79931 2806 4719 4709 2746 3098 2108 116 34 4191 7385 2109 7388 4792 291 1950 7386 27089 2064 29796 1537 440567 4706 PMC3356354__F9 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes 930 4067 6850 695 2885 29760 8915 933 PMC3357406__F3 Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor Development 79572 6775 23604 4087 1432 10198 3714 7040 8515 10602 83990 93185 27131 7372 23760 327 3172 55341 7555 6478 57630 115650 25953 8452 3963 291 51295 23476 9530 3836 3840 2956 641 55723 PMC3357552__F1 Overview of TLR signaling 7100 7099 7097 10333 7096 114609 4615 51311 51284 54106 7098 51135 3654 3663 7189 23118 7187 3665 29110 3661 PMC3359223__F1 Glycolysis metabolic pathway 230 7167 2597 5230 5223 2026 1738 PMC3359641__F3 Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors 7189 4804 2885 627 581 2549 7528 3283 2932 3265 847 2691 4217 5879 5609 PMC3360095__F1 P2X4R-p38 MAPK is a core signaling pathway through which spinal microglia and peripheral macrophages contribute to neuropathic pain and inflammatory pain 6366 100170220 627 4512 PMC3360162__F2 Antigen-mediated chemotaxis 27040 5728 638 9846 4067 2885 6850 6010 6786 PMC3364993__F5 Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes 1950 1956 6714 PMC3366012__F2 TNIP1-mediated signaling pathways 1956 8772 7186 8717 841 10318 836 637 PMC3366852__F5 Proposed mechanistic link between Por deletion and up-regulation of MHC II expression in enterocytes 3157 3156 4598 10654 4597 3422 6772 2224 6713 4047 4261 972 PMC3367549__F1 FGF signaling cascades, an example of RTK signaling 10818 5163 998 2885 6010 2549 5894 572 2353 3725 2119 2118 PMC3367549__F3 Sonic hedgehog (SHH) signaling pathway 6469 6608 2736 51684 2737 5727 2619 51715 91653 374654 8100 5080 2735 4821 PMC3367865__F3 Molecular Biology of Lung Cancer: Clinical Implications 2064 1956 3815 5163 6794 4763 7249 7248 6405 5900 11186 2475 2002 595 PMC3367865__F4 Molecular Biology of Lung Cancer: Clinical Implications 3716 5728 5163 6794 2475 7249 7248 2932 572 3091 4193 595 5155 7039 2056 1021 1019 PMC3367865__F5 Molecular Biology of Lung Cancer: Clinical Implications 572 4609 596 581 7869 5728 595 1017 1021 1019 4193 PMC3368606__F2 Assembly of targeting patches and inside–out orientation of the secretory pathway 100170220 6010 998 PMC3370605__F1 Roles of N-acetyl-l-glutamate synthase (NAGS) and of its homologous enzyme N-acetyl-l-glutamate kinase (NAGK) in arginine biosynthesis 162417 55577 5009 383 PMC3371699__F4 miR-519d, miR-190, and miR-340 in the TGFB signaling pathway 9241 1101 4089 650 6500 4609 1634 387 PMC3372896__F3 Intersection of pathways controlling Wnt/Beta-catenin signaling and cadherin-mediated adhesion 4088 4089 2260 847 1499 1950 2241 6714 PMC3374856__F3 Mutations in glutamate signaling pathway and its associated proteins in melanoma 10718 3084 145957 9542 2913 2066 5662 PMC3375057__F2 Neurotrophins, the ERK MAP kinase signaling cascade, and GSK-3 627 2885 1499 4131 572 PMC3375273__F6 TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation 8772 7189 23118 10454 4772 PMC3376488__F5 MyD88 signal pathway 7097 4118 51135 3663 3662 3661 7189 10454 23118 257397 1386 7124 4615 PMC3376488__F6 TRIF signal pathway 7098 257397 23118 57162 7189 3661 1386 8772 3725 PMC3378547__F5 Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing 29927 3703 6746 58477 6184 1603 29925 5479 83468 85365 9601 10130 10954 64374 51726 10525 9695 22926 7415 6400 9709 7466 7494 468 PMC3379693__F1 Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut 7099 7097 100187907 114609 4615 51311 51284 54106 7098 3654 51135 7189 7187 3665 29110 3661 PMC3380091__F3 Endometrial androgen target gene set 79801 7200 2099 572 887 3717 4128 3091 PMC3380376__F3 Relationship between binding of ligands to the pattern recognition AGE receptor (RAGE) and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro- and microvasculature 23237 3146 4691 1958 PMC3383846__F2 Signaling pathways that regulate cytokine AREs post-transcriptionally 3603 7099 2972 3569 PMC3390960__F1 Formation of the COPII vesicle on the surface of the endoplasmic reticulum 56681 22872 10802 51128 6396 25956 10484 10427 9632 10483 9871 PMC3391582__F2 Signaling Circuitries Controlling Stem Cell Fate: To Be or Not To Be 4040 4041 8549 59352 7249 6009 2475 PMC3392028__F3 Seven important signaling networks of osteoblast differentiation 5741 2247 154 50964 7040 652 650 4041 57154 9575 324 860 23314 387 468 2050 PMC3392173__F1 Wnt signaling pathways 1499 11197 25928 22943 324 6010 6714 51176 PMC3394120__F4 Cytoskeleton remodeling signaling, an example of a differentially regulated pathway in the motor cortex of SALS 7436 1020 5300 8851 1600 2534 847 4741 4744 4747 8936 1639 10540 1499 2932 PMC3394958__F6 Schematic showing observed protein level alterations in VSCC proteome in the context of HPV infection 355 1956 8772 6772 23581 5548 4939 5591 4599 4940 PMC3395887__F3 Interaction of pathogen recognition and ST2 receptor systems with FcERI leads to substantial enhancement of production of cytokines and chemokines 90865 7099 7097 7098 4615 51135 7189 1386 PMC3397508__F1 Possible molecular mechanisms of Ngb neuroprotection by modulating cell death/survival signaling pathways 58157 718 717 1537 PMC3397897__F8 Schematic presentation of signaling pathways and their downstream targets that are affected by a feedback loop between hBVR and PKCD 7124 5091 2353 PMC3398238__F7 A ubiquitin-binding protein FAAP20 links RNF8-mediated ubiquitination to the Fanconi anemia DNA Repair network 57697 91442 545 9025 9656 2177 PMC3398464__F1 Key branches of the insulin signaling cascade 50507 857 3667 8660 5728 5170 2885 55959 7249 6009 345 PMC3402681__F1 Proposed mechanistic model on how SHARPIN regulates TNF-induced NFKB activation through linear ubiquitination-mediated mechanisms 7124 7186 8717 81858 23118 257397 5970 PMC3405863__F5 Segmentation clock oscillator 28514 4040 324 1499 3955 1848 3280 84667 388585 100188776 23462 22943 441478 2885 10818 PMC3411062__F1 Network pathways analysis of molecules identified in T-cells that are involved in LFA-1/ICAM-1 signaling 2323 64750 923 6498 7039 80176 4092 659 10252 57154 4133 5604 23462 3678 1026 1033 182 29940 54880 4176 3516 3714 4300 3620 PMC3411757__F1 Modular Nature of Dendritic Cell Responses to Commensal and Pathogenic Fungi 6850 5894 5971 5336 64170 8915 3603 6361 6364 4513 4067 6010 6714 6772 7098 6041 6035 4938 4261 941 9308 9636 PMC3413046__F2 Integrated functional association analysis of protein and genetic interactions on alanine and aspartate 9517 57017 6470 64902 55304 9326 2101 51166 55034 6472 23464 4942 51540 2731 3172 390110 212 29968 8942 84706 2875 18 9054 8879 2806 10231 2746 23042 189 51380 3067 1644 2571 5091 3421 3417 3418 48 PMC3415708__F5 Novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer 226 3939 37 1892 27349 10449 3030 5106 50 2639 2271 4967 6392 PMC3417440__F1 Cell death regulation: Signalling pathways and potential sites for pharmacological intervention 9118 355 7124 8772 8717 7186 6010 1499 572 637 317 6714 581 331 596 595 1019 2475 6774 PMC3418847__F6 Interaction Map for PTMScan Direct: Akt/PI3K pathway reagent 5295 5296 5290 8503 5298 1969 5728 6461 3667 8660 545 3265 3845 8498 253260 5163 9046 1500 2475 5311 207 10397 10000 208 5747 8570 2932 2931 3932 2803 5062 2534 7458 6194 4790 2308 572 50488 221937 8428 10494 331 PMC3421022__F1 The prolactin signaling network in NetSlim 5479 5617 1509 5618 3688 140885 1154 7534 7532 3716 7535 7006 100124696 9021 6714 8835 8651 4752 3667 5478 116986 6772 867 6464 6654 3717 5879 5295 5296 3265 2885 5290 5058 9846 4790 5894 5970 5829 207 2316 5604 5599 836 2475 5601 5594 5595 1432 6194 10401 2002 3725 4609 2353 4843 PMC3421730__F6 The antiviral IFN response in infected THP-1 cells 8737 8772 7189 7187 57506 9636 10010 29110 85451 3661 5300 3725 3441 3458 PMC3422784__F5 Sensing the environment: Regulation of local and global homeostasis by the skin neuroendocrine system 121278 7166 4199 15 9 1557 PMC3423373__F3 Transcriptional Programs Controlling Perinatal Lung Maturation 2149 2255 7004 7078 2152 5155 5295 1906 5468 3791 355 5797 2624 7422 10370 5925 3958 5054 718 196 7111 348 1942 8829 2683 94 7049 64321 50848 9064 2022 659 10365 2980 650 3611 3579 1839 153 10538 10488 3059 1233 2353 3689 3727 9021 5791 5581 613 1439 1956 9659 1441 23594 10376 7057 8317 472 10926 4831 54700 4999 11200 1871 1111 3148 6418 4801 51053 328 3146 641 83746 5111 1894 11335 9656 1017 675 2547 2146 23450 699 10155 3070 991 55872 79813 11243 6599 84733 50804 7913 1062 PMC3423502__F6 Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud 6911 22943 399473 PMC3426818__F5 MUC5B gene expression is transcriptionally regulated by various mediators and pathways 3605 3553 2064 2065 6667 727897 PMC3427155__F2 Analysis of Differential miRNA Expression in the Duodenum of Escherichia coli F18-Sensitive and -Resistant Weaned Piglets 1729 2252 160851 8031 488 9525 10507 6272 1910 50848 100302155 5577 8313 6387 5565 112398 3908 5934 1902 8555 71 5290 1075 3915 92 27115 8243 1050 1956 10154 5156 27 1385 1268 5515 867 4089 7416 26047 10672 10735 9575 3482 392255 10891 5144 3707 406927 10846 7148 1634 868 8829 214 3676 2908 5797 5530 PMC3427211__F3 Microbes-induced EMT at the crossroad of inflammation and cancer 7096 7097 7099 10333 7100 51311 54106 7098 51284 114609 4615 64127 9447 10392 29110 834 3603 7189 3661 54472 PMC3427795__F1 Interplay between FOXO, TOR, and Akt 3479 10000 207 208 5728 143686 7249 7248 6009 2152 1977 PMC3428770__F2 Signalling events activating PKB/Akt and cellular functions regulated by PKB/Akt 5163 3716 2549 3611 9846 5728 6850 7248 7249 5894 9882 11140 3064 1977 331 29110 367 572 4193 65125 PMC3429538__F5 Highlights from this issue 26284 7157 55332 PMC3432194__F2 Epistasis network for WTCCC GWAS of bipolar disorder 55711 120114 6555 55247 9904 7347 2898 9630 1496 6595 85413 23291 6239 51090 84144 64121 8553 55304 9187 10085 25928 1601 160335 643418 253430 64478 25 116984 2861 2274 6996 1188 23198 25769 8780 1804 341019 51335 9844 114801 9373 51741 51649 288 57537 84620 8774 93627 340441 253769 79627 80184 57419 64426 11149 54476 55576 6402 64089 11086 8564 10580 54622 859 9742 8543 129607 118 10777 5789 10492 7545 3274 6035 23136 10659 114788 9366 57705 55781 PMC3432767__F1 Rac and RhoA signaling pathways during cytokinesis 5879 387 1894 10451 6010 8874 5062 5058 PMC3433899__F3 Single gene and protein network generated by Approach 3 (Network 1) that demonstrated significance as a clinical relapse predictor following a stringent permutation based test 2495 4830 142 3866 47 7373 427 1382 1634 721 4638 644 9961 1265 3315 PMC3436686__F6 Ensemble representation of EGF signalling network 1950 1956 3691 4088 5829 5594 2887 6714 6464 5604 3725 7431 5595 5781 5587 867 2885 5578 2353 6654 857 369 3265 10253 5590 5894 596 5801 5747 PMC3442804__F2 Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter 1950 8772 3265 5337 PMC3443208__F4 Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression 100500828 51809 4883 619556 4860 100616363 8742 8774 26524 83440 2104 7127 100126296 100616247 114990 3868 25805 5447 2057 28999 6935 64400 22884 207 4072 9049 406961 27252 102466726 8823 1969 595 10309 3298 5598 659 10114 29116 PMC3461607__F1 LPS/TLR-4 signaling pathway.Notes: LPS is delivered to CD14 by LBP, which in turn transfers LPS to TLR-4 3929 929 10333 7097 7096 7100 4615 3553 PMC3464294__F4 Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells 5328 5327 5340 7422 7448 11197 5329 4691 4041 10454 4087 4088 1398 3611 331 10023 847 126669 1793 7409 51701 387 2885 4193 5879 3985 4316 3984 3265 5058 1977 2475 PMC3466334__F3 Genetically-defined metabolic reprogramming in cancer 2271 3417 3418 9817 PMC3466514__F1 S6K1 in ER-positive breast cancer 1950 7248 5163 3667 5728 1956 2064 3480 7039 PMC3469658__F3 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes 10713 84640 26227 23037 51076 4719 7534 3172 2182 6132 4613 7174 6206 3600 5163 7124 4609 6170 51744 6167 3558 409 285855 84844 3265 822 1266 5159 56925 10494 6510 58533 PMC3469658__F4 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes 10494 9590 3600 6402 367 4843 3172 7157 7124 7072 6046 1956 26227 51185 79865 822 2791 59339 58533 6643 PMC3470584__F2 Suppressed RNA-Polymerase 1 Pathway Is Associated with Benign Multiple Sclerosis 54700 4609 4897 27125 51082 4772 940 10128 3458 6597 9641 5442 3248 7157 7189 6595 9967 960 861 10758 6909 6165 1606 814 1739 8996 43 472 23560 2113 78986 171023 54552 939 7314 23299 10063 5884 9282 1938 55501 3655 11221 8877 7980 6194 8655 22795 2274 11167 831 5782 1969 8542 6891 PMC3472969__F1 Genotypic-phenotypic model of estrogen metabolism and exposure (yellow box represents genotype component with phenotypic factors outside) 1543 1545 1312 3006 PMC3488210__F5 Significant sub-networks (see also ) found among the lists of most essential genes, ranked by the RIGER parameter, obtained for both cell lines: (A) Jurkat and (B) K562 4609 6944 56949 8089 55646 51562 7555 396 5971 472 5970 64087 6201 4113 6129 PMC3488630__F2 Proposed model of HER2/3 signaling in epithelial cells 3084 3553 6868 999 PMC3489747__F2 TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis 29110 8772 1311 3661 PMC3492208__F3 Principal IFN-Alpha-modulated canonical pathway in MT-4 cells 3458 6773 6772 8554 581 3430 10379 3659 5696 2695 PMC3493930__F8 Mechanisms by which AP-1 transcription factor regulates LY6K expression, which activates the ERK signaling pathway to mediate cell invasive motility and metastasis in human breast cancer cells 54742 5077 2638 PMC3494151__F4 Impact of SIRT1 knockout on selected cellular pathways and protein complexes 2237 5111 142 3978 3065 53366 6634 6633 6627 23020 6625 6631 10992 9343 9129 24148 6626 23451 26121 10291 10594 23450 9128 84844 9416 10946 11325 220988 3190 3178 11338 1665 5093 58517 84991 55660 22827 4670 10523 6434 55119 10915 27316 1655 10285 153527 4686 3192 11143 64769 51147 84289 904 55929 23476 80314 1025 57634 10902 23411 54556 8295 8607 6944 8089 10856 PMC3494597__F1 Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells 8883 9040 64798 2475 9474 PMC3496878__F1 Signal transduction in solid cancer cells including hepatocellular carcinoma 324 998 1537 1398 6714 4763 3725 8195 4342 2885 2353 1956 6010 8213 6774 2475 5728 2191 355 572 637 PMC3499976__F1 Wnt transduction pathways and their functions during synapse development, function and plasticity 847 324 2932 1499 5662 6010 4131 4133 4593 PMC3500853__F3 EphrinB reverse signaling 3717 5058 998 387 6010 PMC3502514__F1 Activation of stress signalling pathways in the liver of sows during lactation 54658 2876 9588 7296 3240 2266 629 1401 PMC3502876__F1 Reactive oxygen species-mediated autophagy regulation 5052 5728 7001 472 7248 6009 664 2475 8408 9706 64798 64223 7405 3146 9474 9140 PMC3504641__F1 Schema of the cholesterol pathway 6713 4047 1595 7108 50814 11161 10682 1718 PMC3507178__F3 Flow chart depicting the metabolic pathway of fatty acids in the liver of GH transgenic Amago based on 3′-tag digital gene expression profiling and comparison of serum triacylglycerol and glucose, and 3-hydroxybutyric acid 4023 7038 95 2180 355 60481 58526 54898 79071 PMC3507272__F1 Schematic diagram showing the RAS-MAPK signal transduction pathway 2885 673 5894 PMC3508562__F1 Diagram representing the possible endogenous and exogenous TLR activation pathways and the accompanying response.Abbreviation: TLR, toll-like receptor 1896 7097 7099 PMC3509712__F1 Signal transduction pathways used by superantigens and mediators 7124 3716 27040 8772 3932 7535 100187907 7189 2885 5163 6010 3717 759 2475 2002 6722 10379 3659 PMC3511450__F5 Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways 7039 1950 685 3084 1605 2475 5170 3708 5582 5580 5584 5588 5583 5590 1399 1793 1398 2549 673 717 2885 3635 9846 3636 3716 3717 4296 4294 9175 7786 389840 4215 4216 10746 4293 9064 1326 5879 1956 3552 3569 3553 7124 5579 5578 814 3718 958 7188 729 727 1147 8517 9641 3551 5606 5608 6416 5609 6885 4217 5600 8550 9261 7867 8986 9252 51295 6714 7189 730 2064 2065 2066 5894 4214 5605 7100 3554 7850 3572 92610 4615 7186 7133 6198 3667 5604 6195 6774 PMC3512574__F3 TGFB in Cancer 100187907 998 5062 4838 10637 7044 7189 6997 6010 3984 652 650 10097 392255 151449 8200 269 7045 PMC3513217__F3 Metabolism pathway of tamoxifen and its interaction with estrogen receptors.Copyright © 2009 1555 1576 2328 1559 1565 2326 1557 6817 1544 1577 PMC3513309__F4 Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine 940 941 942 920 958 1493 6850 7535 613 998 695 1445 5163 2626 2322 2885 4193 9846 2056 2475 9978 1977 405 8453 2002 572 PMC3514620__F2 DNA repair pathways and implicated proteins 2956 4350 472 57697 545 84126 55215 9656 79728 6741 PMC3515332__F1 Class I PI3K/Akt/mTOR axis pathway 3667 5728 5163 253260 2308 572 581 1977 PMC3517193__F1 Graphic illustration of the perturbation of the insulin signal transduction pathways by cellular stressors 867 2885 8471 3667 8660 5728 5163 2475 2000 572 2002 PMC3517549__F5 Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses 23098 4118 4615 51135 3654 7189 23118 10454 6890 PMC3517905__F1 Summary of the signaling pathways of PKMζ-mediated late-LTP 5590 847 2475 5300 5163 5315 4905 627 PMC3518431__F1 Autophagy modulation as a potential therapeutic target for diverse diseases 5912 6009 8408 3643 7942 PMC3520048__F2 Summary of the role of the mammalian target of rapamycin (mTOR) signaling pathway in the development of tuberous sclerosis complex (TSC) and inhibition by mTOR inhibitors 5163 253260 3667 7248 7249 6009 29904 1975 1977 PMC3522801__F1 DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis 472 672 10111 4361 1869 3014 4193 581 PMC3522801__F2 DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis 472 545 995 993 5371 672 983 1017 581 PMC3524319__F6 Construction of the regulatory networks associated with the selected genes using IPA® database 3458 729230 5699 6280 7124 5292 5698 710 958 3937 6347 5970 3569 3394 5265 9021 10875 3665 4600 3561 3600 3601 3434 4939 837 9235 1390 3437 5341 4261 10906 1522 3430 3433 2335 2633 1666 2209 6609 971 355 3659 2833 8651 3383 2203 11118 9516 3627 5721 3587 PMC3528279__F2 Toll-Like Receptors (TLR) signaling pathway involved in hMPV-induced gene expression in primary immune cells 7099 51284 929 3398 114609 4615 51135 3654 7189 7187 29110 3661 3663 3665 5970 PMC3532876__F2 Vicious spirals of repeating self-accelerating oxidative stress and dysregulated redox and information signaling as possible causes of type 2 diabetes 208 3651 10628 50507 389692 57716 PMC3533466__F1 Genes whose mRNA expression is suppressed by nicotine in RAW264.7 cells under poly(I:C) stimulation compared with those under poly(I:C) stimulation only are mapped to three gene networks, as predicted by ingenuity pathway analysis (IPA) 3929 114609 54472 8772 367 3665 3458 3569 PMC3533466__F5 Nicotine’s effect on multiple signal transducers in the downstream pathway of calcium 1956 7409 6714 5879 6464 5058 9846 1605 2885 1386 2475 6722 4609 PMC3534236__F3 Autophagy and selective deployment of Atg proteins in antiviral defense 7098 7097 7096 10333 51284 54106 9474 10533 7939 PMC3535349__F2 Iron transport across the placenta (syncytiotrophoblasts) 3077 7036 2242 5093 55240 PMC3536146__F8 Pathway representation of canonical and Pyk2-mediated TLR9 signaling 54106 4615 3656 126669 8772 7189 7187 23118 29110 3725 3661 PMC3536591__F2 Ingenuity pathway analysis (IPA) top network that incorporates 9 genes identified as differentially methylated between methotrexate-naïve cases and controls by HM27 analysis 6895 8575 10642 6278 83939 10231 4603 5610 7073 4609 132660 623 4512 4852 9134 284217 4352 3061 PMC3538588__F8 Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes 4089 3458 4091 4092 9978 8454 6500 4052 387 10468 5308 4838 PMC3539252__F3 Upregulated HCV gene signature is enriched for interferon (IFN) pathway genes 4061 91543 10379 4940 4600 PMC3540890__F1 Biosynthetic pathway of prostaglandins 4512 4513 2689 5226 5228 PMC3543073__F2 Three examples of chromatin-modifying complexes and their mode of action 9112 8932 53615 7503 9055 1788 22893 9869 3065 3066 4152 7018 PMC3543090__F4 MicroRNA-182-5p targets a network of genes involved in DNA repair 5884 5810 7534 7531 7158 3364 994 995 9586 4436 545 472 1111 5932 11011 11200 580 672 993 27343 11201 6604 8841 5925 7157 1017 1026 7283 466 7153 1647 595 902 1021 1019 1022 7027 1027 6500 8454 6502 8945 PMC3543749__F1 Insulin/IGF-1 signaling pathway 3479 3481 8471 3667 8660 8651 9021 5728 207 208 10000 2308 10110 6446 23035 23239 23410 22933 23411 5934 901 595 894 847 6648 6342 356 604 10018 7874 6502 3643 PMC3543749__F2 Telomere maintenance pathway 25913 1200 55505 7015 7012 55651 PMC3549672__F2 Ubiquitination in Signaling to and Activation of IKK 1283 3661 7706 57534 142678 PMC3552307__F1 Double-stranded and single-stranded RNA signaling pathway 8772 7186 54106 51284 7098 4615 7187 7189 3665 3663 3661 8195 PMC3552779__F1 Aerobic glycolysis, the citric acid cycle, and key glycolytic shunts 3099 2821 5213 2147 2597 5230 26227 2023 3939 PMC3558493__F8 ErbB2-Dependent Chemotaxis Requires Microtubule Capture and Stabilization Coordinated by Distinct Signaling Pathways 2064 387 998 5879 5058 324 PMC3559342__F4 Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin 79088 1478 30008 22983 580 200030 2639 11331 221472 10236 9150 6607 6606 3117 10921 6820 81608 9785 29959 8988 27252 10280 2301 1201 10927 408 5655 55363 8943 53615 55661 PMC3560328__F2 DNA interstrand crosslink repair and cancer 57697 2187 80233 2175 55120 2178 2189 2176 641 80010 2188 2177 55215 116028 22909 672 675 545 PMC3560328__F3 DNA interstrand crosslink repair and cancer 2067 57697 2177 5888 5889 675 672 80198 146956 22909 51455 641 51199 PMC3560853__F3 Scheme showing the potential molecular events induced in cancer cells in the hypoxic tumour microenvironment 7852 7428 5230 2475 596 5315 4609 3569 79923 6657 9429 PMC3562183__F2 Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle-Invasive Bladder Transition Cell Carcinoma 6502 1017 10000 10451 10401 4690 4351 387 2885 7424 2534 673 5921 1612 4763 868 3716 355 858 PMC3563666__F4 Altered Cytokine Gene Expression in Peripheral Blood Monocytes across the Menstrual Cycle in Primary Dysmenorrhea: A Case-Control Study 654 8200 7124 652 659 4086 4089 4313 5468 2033 5465 842 596 3162 836 841 6647 7018 5743 PMC3564018__F10 Stress-suppressed genes involved in antigen presentation and synapse formation 920 6891 3458 2923 811 4261 7124 3558 7099 929 1234 919 1236 965 914 3689 3683 3383 7054 PMC3564018__F7 Transcription factors predicted to be inhibited by battlefield-like stressors and their targets among stress-modulated genes 3123 3122 973 3308 3113 1000 6566 3112 3106 5140 1385 3146 567 6648 4261 3659 1026 972 3665 5971 3500 4790 5970 3606 1277 3552 10318 6305 4060 2919 5196 8870 1263 960 1236 2 59 174 PMC3565105__F1 Hypothetical model illustrates the E2-ERA signaling pathway involving both genomic and extranuclear signaling pathways 9112 207 6714 2932 4827 27343 11201 27043 PMC3569094__F1 Novel therapeutic approaches for overcoming limitations in the gemcitabine pathway 978 1633 6240 6241 PMC3570300__F5 Ingenuity Pathway Analysis of proteins induced by DNP.A, overview of 15 specific functional networks, each of which contains 11 or more “focus” proteins (proteins that were significantly up- or down-regulated) 51119 717 367 596 4313 9656 5954 6304 6102 79923 6623 5576 5829 3655 5577 1956 7161 8087 3481 10553 23404 5394 5329 4548 6774 8694 4714 PMC3574110__F4 Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice 2817 9509 1491 7058 467 622 8553 9049 650 123 1356 PMC3574586__F2 Schematic representation of the sessile and traditional serrated pathways 673 3845 3490 4292 4255 PMC3574819__F10 O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation 472 545 3014 PMC3575666__F4 VPS4B downregulation increases the expression of mitochondrial fatty acid Beta-oxidation related proteins and down regulates the expression of glycolysis related proteins in SKBR3 cells 3098 3099 226 230 2597 34 5230 2194 2023 3030 3939 8050 3945 3032 4191 1431 47 2271 8803 3419 3420 PMC3578301__F4 Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets 3714 182 3458 2625 50943 6095 PMC3579516__F7 Alliance for Cellular Signaling Plasmid Collection 2264 3791 3643 3815 107966124 238 4067 4058 6259 640 3702 2444 6723 7006 100124696 8767 10097 1445 2242 2241 659 4342 8445 203447 340371 65268 197259 9748 55681 93627 6041 6035 4661 7465 83903 8317 1022 10733 11011 2580 1263 25989 10769 156 131890 54986 2868 367 152110 29941 5616 5613 26524 84033 10290 65975 84930 23139 7204 9475 30811 54861 1760 375449 90956 5311 5310 23617 23604 8573 9024 81788 9261 85481 472 57787 4140 3024 2011 PMC3579782__F6 Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy 5081 3569 6722 3479 2660 4617 6772 6774 3716 3565 6773 3717 4513 PMC3580589__F3 PTHrP signaling pathways during endochondral ossification 3549 8314 864 860 PMC3581534__F5 Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor: An Interactomic View 4176 254394 3178 11006 1601 10628 9211 5479 7086 9468 10450 1993 611 9689 80742 7504 2152 5700 8192 3838 5539 811 6232 629 2821 443 2242 6628 5328 3087 1562 PMC3581534__F7 Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor 55131 7292 4744 1047 23469 347 9019 6511 50937 23191 26292 1439 10123 1811 11331 83884 6948 6003 286451 2065 3990 6373 7358 57559 1384 79135 374 80896 3861 54549 8820 22924 6595 4879 PMC3584666__F1 Toll-like receptor (TLR) signaling pathway 7099 7096 7097 10333 7100 4118 4615 51311 54106 51284 51135 3654 7189 7187 23118 10454 29110 3661 3665 PMC3588051__F3 Ingenuity Pathway analysis of lung cancer and/or COPD versus controls revealed NFKB as a major foundation 5478 1072 1401 3417 1992 7316 7430 2936 2950 847 2939 1509 PMC3588201__F1 Gene regulatory networks for cDC and pDC development 55509 10538 2322 6774 3662 5971 3398 5132 2672 PMC3590362__F1 AGE/RAGE signaling pathway in NetSlim- This map represents the NetSlim reactions of AGE/RAGE signaling pathway in different cell types 3630 4323 4322 4318 1650 3958 4481 4316 3643 1956 4313 6714 5578 5580 3717 5579 114609 387 4846 4615 3265 51135 6774 5590 998 6647 1147 3551 4843 54205 4792 1432 7430 4478 836 4303 4087 5970 4790 1386 3725 6667 842 249 5972 2308 4088 PMC3591264__F6 Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression 7417 7314 1329 5464 537 PMC3591264__F7 Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression 10528 6204 6235 6170 6191 6187 6159 6167 6160 3921 6137 6136 6169 6193 11224 6233 6229 6157 6173 6152 6122 PMC3601164__F3 Links between Toll-like receptor 4 and breast cancer 7099 4615 7187 29110 3661 PMC3603002__F6 T cell signaling pathways and protein phosphorylation sites identified to be differential between NOD and B6g7 mice in stimulated cells 920 5777 5781 5829 5786 6464 998 6010 50618 7294 27040 3932 921 1445 55824 4063 PMC3605164__F2 New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic Beta-cells 4040 4041 8312 324 2932 1499 PMC3605242__F6 Ingenuity Pathway Analysis visualization of oncogene interactions 8600 1634 5329 2771 948 3560 100133941 2065 5788 3815 558 2064 6868 3688 3690 54106 3643 4615 8773 7100 7852 3654 1956 1439 1601 6623 5518 4067 5580 3718 5515 2316 10755 4217 8660 8772 57162 6464 695 207 5339 4646 5521 2885 1808 26060 3312 5629 7532 6670 836 8493 4739 867 1027 8517 7128 595 4087 983 3059 4193 6774 545 11315 5925 2547 3727 1602 7157 1051 8850 472 11200 1022 3725 3301 2736 27043 9282 5888 10926 995 6597 8031 2353 5371 7158 672 PMC3606422__F1 Methotrexate mode of action 5981 4363 1244 8714 10257 9429 5243 100 2356 8836 7298 1719 4397 4524 PMC3606754__F2 STRING analysis of the relationship between genes 4320 28 5091 56729 4282 56244 4314 3791 7042 3135 100507436 7422 3240 1401 3106 7054 1636 4049 121278 2956 PMC3606754__F3 NF-AT signaling and leukocyte interactions have been enriched by GeneGo 613 7535 27040 958 3566 3565 6778 3702 3932 1232 759 3597 3717 PMC3607076__F4 Selected summary of the ATM signaling network 472 545 1386 3150 23300 2539 9656 7249 80254 699 9025 165918 56254 9810 55183 9759 3014 PMC3612515__F1 Graphical representation of Ingenuity Pathway Analysis results showing significant predictors genes in ‘Gene Expression, Cell Cycle, Cancer’ pathway 23204 219699 10038 5530 8556 53354 2580 819 5596 7157 2287 5063 1371 149628 26586 63970 84289 8805 5888 10512 3276 PMC3612515__F2 Graphical representation of Ingenuity Pathway Analysis results showing significant predictor genes in ‘InflammatoryResponse, Cell Death, Infection Mechanism’ pathway 55975 7050 55294 9978 23204 23113 2580 7917 2287 4124 1161 63970 8805 23389 7157 219699 9937 5063 10512 84289 5260 149628 5538 PMC3612776__F1 Pathways affected in monogenic hypertensive disease 1638 65125 65268 26249 8452 1584 4306 PMC3612853__F1 Signaling and transcriptional regulation of Th17 polarization 149233 196 50615 6774 2475 3662 7043 10538 861 6095 50943 3458 2625 5914 6778 6772 6775 3566 PMC3618249__F2 Single drug simulation result on T2D model 5468 8660 2888 3643 5163 867 181 3667 6464 6654 5781 2885 3265 PMC3618688__F4 Resection of Non-Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System 54472 7189 23118 10454 4790 5966 5971 2002 929 7099 114609 4615 7100 7096 7097 10333 54106 81793 PMC3621568__F1 TGFB transduces signaling through Smad and non-Smad signaling pathways 4087 4088 57154 4089 6722 3725 1386 PMC3624394__F4 Comparative analysis of NOTCH signaling pathway components in calcium-differentiated 8E6-iHFKs and GSI-treated C-HFKs by qRT-PCR 3955 9794 84441 4242 8650 3280 2033 22938 5986 1840 4851 388585 28514 4853 23462 10683 23493 3516 54567 26508 4854 4855 171558 182 9612 3714 5663 55851 5664 102 7088 3065 23385 6868 PMC3624769__F1 Interferon (IFN)-Gamma-activated pronecrotic and prosurvival signaling pathways 8772 3716 3717 6772 197259 6648 PMC3632094__F8 The process of LC3-associated phagocytosis (LAP) 11035 9474 10533 7939 PMC3632399__F5 RAS oncogene signaling 3725 7422 2247 6667 6668 4318 4313 4513 PMC3632644__F2 GLI1 Isoforms and cancer characteristics 6469 2735 100133941 79923 7422 PMC3632731__F2 Network 2 (metabolic disease, renal and urologic disease, and molecular transport) generated by pathway analysis of the hot list 5798 117 10411 2893 4162 100505854 3913 2923 6263 7008 351 2357 4053 6696 4267 226 PMC3635536__F5 Signaling Pathways in Schizophrenia: emerging targets and therapeutic strategies 3084 1950 2885 6654 2475 6722 27185 PMC3638770__F4 Two major pathways to apoptosis 8772 572 637 581 472 PMC3646863__F4 Prognostic signature of G₂ checkpoint function in melanoma cell lines 3815 1741 5797 23433 219539 55619 4286 3383 23500 11169 8850 1386 3725 3299 253714 545 472 8924 23243 57045 4088 994 51496 4331 983 5694 1163 83852 324 5713 26271 3169 PMC3652384__F2 The mechanism of late PC 3716 3717 6714 3932 6774 6772 PMC3654194__F1 Spatial and temporal organization of ubiquitin networks 958 4615 51135 7189 8717 7186 3654 81858 23118 10454 PMC3657575__F10 The signaling pathways involved in calpain-mediated regulation of dendritic protein synthesis induced by BDNF 627 2549 5728 2475 PMC3657702__F1 Age-related alteration of gene expression in the TCR signaling pathway 920 1493 3932 962 867 2534 952 27040 389 3702 2885 8915 29851 940 5163 PMC3659569__F2 Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies 2308 200186 355 PMC3660063__F1 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response 5728 5295 23533 30849 5290 8471 4763 7249 7248 6009 64798 2287 2475 8408 PMC3660694__F1 Oncostatin M signaling pathway- NetSlim (http://www.netpath.org/netslim/NetSlim_114) map generated to graphically represent the different reactions induced by OSM in various cell types 5008 3977 3572 9180 3717 2185 3718 9021 2885 3667 6714 6654 6464 5829 5894 3265 836 3845 840 5580 842 5578 5579 253260 2475 5581 5583 5594 4792 5601 5595 6772 6774 5970 4790 10401 1027 1385 1051 2353 3726 3727 1958 3949 7422 7157 5054 4314 4322 7078 PMC3661706__F1 Association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer 3929 929 59307 114609 4615 7187 54472 10010 7189 406991 27250 3661 7099 PMC3662247__F3 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity 7248 7249 5728 2475 8772 5163 4193 5894 637 65018 4976 7416 8408 331 836 842 317 7189 983 55626 5266 84971 9474 7405 81671 3146 1869 10533 57103 581 664 9140 PMC3662247__F4 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity 3146 834 29110 9447 7189 9208 4615 3661 3665 4077 7416 7099 114609 7096 7097 10333 7100 54106 100133941 54210 51311 51284 7098 PMC3663490__F5 Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer 472 10111 4361 3014 9656 672 637 1111 570 2177 4193 641 PMC3663815__F7 Pathway summary of peptide array and antibody array results 3630 3667 572 5163 5728 2308 7248 7249 6009 673 2475 1977 PMC3670238__F1 Spectrum of STAT functions in mammary gland development 5617 3976 3597 5618 3977 7297 3717 3716 8651 9021 8554 10401 3488 2625 8835 5295 6590 929 116844 PMC3671299__F2 Schematic diagram of AB accumulation mechanism 4035 83939 6722 93649 23621 6721 43 PMC3671630__F1 Nucleotide excision repair 1642 57654 7508 1643 5426 51426 5111 7515 3980 7507 2067 PMC3676649__F2 Musashi signaling pathways associated with mammary progenitor cell expansion 27122 2932 3714 1499 100188776 4851 595 8650 4609 4440 4040 4041 PMC3677161__F5 Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease 64005 9056 199 5777 2357 920 6282 1441 5880 112616 29108 341 834 5265 7305 10437 945 51296 4542 7462 1794 2896 2876 2207 6850 1796 51338 4067 54502 11027 140 7046 29760 4602 1475 1192 861 5966 64098 54918 3108 972 5742 3109 3122 10863 7097 10312 257106 5788 1520 4242 10257 3597 706 7133 3588 3587 3606 PMC3680388__F5 Novel Strategy to Increase the Proliferative Potential of Adult Human Beta-Cells While Maintaining Their Differentiated Phenotype 85407 2535 89780 8324 7473 80312 4041 55388 1857 6422 6925 5156 2932 10577 6423 4088 4089 864 8607 6774 3717 3358 3716 7297 7365 10692 10090 2099 1282 574537 59 4087 7077 1601 5609 PMC3681753__F8 Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses 6405 84282 4909 7706 340706 9033 492 7189 5704 8772 7187 841 843 5708 10010 23390 284486 3034 54961 6611 53615 94103 9968 5430 7544 159119 324 1499 116154 57475 4158 399 2215 56133 10188 10825 222962 54868 7036 55281 PMC3688534__F10 Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors 4320 7482 627 9236 26051 5956 30819 4696 58488 375444 134218 6667 1406 3064 1050 4332 PMC3688827__F6 Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial Infection 3685 5329 7057 5817 6714 7040 3726 3839 1499 1958 405 4609 5966 196 4790 114548 3162 10049 6648 3300 1026 2729 9709 7296 355 4363 3553 PMC3694431__F5 Interaction networks of significantly regulated genes from interconnected neurons 7 days post-infarct 23135 26585 3625 91833 4745 4958 9655 5173 63827 8490 1081 5653 7078 7430 2199 348 10097 9049 361 6452 3107 5829 121441 2318 123 57159 1994 4000 2237 4741 6502 4747 51100 54453 6237 202559 9584 4831 4744 9669 57678 2791 10509 2770 54810 10755 2783 3064 2773 59345 10287 2771 2782 1822 2146 1742 4851 7157 11244 6667 1743 657 6844 658 57154 PMC3694992__F1 Neuroimmune Signaling: A Key Component of Alcohol Abuse 3146 929 114609 7099 PMC3695728__F2 Exploring mechanisms of FGF signalling through the lens of structural biology 100187761 2885 2549 4082 5335 572 581 2353 PMC3695741__F2 Nicotine and Pathological Angiogenesis 7220 7224 7223 5163 572 PMC3696550__F6 Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia 613 933 5880 7409 7410 10451 4772 638 5534 4773 4775 5532 4776 2885 6655 5594 2353 5595 5894 25780 3845 2638 2213 3725 84433 8915 4791 10892 5290 975 930 207 208 1147 5291 5296 8503 3551 4793 10000 1493 868 916 324 4690 8440 5058 27040 387 7006 100124696 5530 6654 5533 3458 1437 7124 6885 1019 4790 5295 4792 4794 5293 23533 5294 5163 2932 PMC3696556__F4 CD4+ follicular helper T cell infiltration predicts breast cancer survival 920 940 1493 923 27240 55824 27040 54923 1445 3932 5335 2534 5775 10000 10235 867 10892 8915 80824 4794 5966 3725 10538 2353 7908 151888 939 PMC3696556__F5 CD4+ follicular helper T cell infiltration predicts breast cancer survival 920 940 1493 923 55824 27040 2534 84433 3932 1445 6786 8631 7535 5163 814 3702 5775 10000 10235 8915 10892 718 1847 4794 5966 2353 3725 10538 3559 3604 29851 4345 151888 941 942 10750 56253 3958 5133 952 939 50852 27240 PMC3697769__F2 Signaling pathways activated in cord blood-derived CD34pos hematopoietic progenitor cells (upper panel) and in erythroblasts at day 6 of differentiation (erythroblasts, lower panel) 4851 6418 3716 64798 2475 572 2308 1399 126669 2549 891 595 PMC3697783__F8 Wnt signaling pathway 51701 5624 1499 4089 4040 4041 6500 8454 324 9978 PMC3703268__F6 Network view of TGF-beta signaling pathway alterations in colorectal and ovarian cancer 4605 8202 1191 5520 1869 4089 10397 7046 22919 6885 3297 1387 3172 7048 324 9611 6498 5595 4609 5604 4087 8904 4088 7553 4092 9372 2033 60436 10221 8928 79183 6416 23054 PMC3704221__F1 miRNA biogenesis pathway 29102 54487 26523 192670 27161 192669 1233 PMC3706566__F6 Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization 4899 23411 23410 7351 7352 9927 55669 51024 PMC3707630__F7 CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex 4282 960 972 6714 6010 595 PMC3717195__F1 DNA repair systems 10111 472 4361 9656 9156 672 9025 5888 3978 7516 7486 3981 7518 5111 545 84126 11073 7507 2067 1642 7508 1643 56949 11284 5423 54840 7515 3980 2237 8505 142 55775 PMC3720582__F1 Comprehensive Hedgehog Signaling Pathway 864 91653 50846 3549 6469 55733 8643 6608 5727 64399 27148 51684 355 2736 2735 4851 2737 6497 8650 6788 83737 894 6925 PMC3720582__F2 Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer 864 55733 91653 2619 50846 6469 3549 5727 64399 6608 8643 51684 27148 2735 2736 83737 8650 6497 6615 596 6925 PMC3721368__F1 Schematic depicting the canonical and noncanonical TGFB signaling systems coupled to EMT in MECs 4088 4087 6714 57154 4089 387 3611 2475 6774 6935 PMC3722525__F7 Antigen processing and presentation pathway and the cell cycle pathway 9241 4089 4090 4086 659 4091 4092 3458 972 64750 57154 4052 7046 4087 4088 7048 324 1634 699 9184 991 PMC3724648__F6 Model showing the effects of PP2A in SLE T-cells 6667 1997 10209 1786 970 3383 PMC3726008__F5 Dose-dependent MeHg-induced gene expression alterations within the Wnt-signaling pathway 6500 8321 6907 4088 5663 5567 79718 8454 9978 4041 4040 57680 51176 6422 6932 2932 586 324 1454 1452 57216 9620 9475 23002 387 PMC3726361__F4 Focal adhesion signaling pathway highlighting those genes that are differentially expressed compared to untreated control ovaries and identifying by color the treatment group(s) from which the differentially expressed genes came 387 7408 3611 5728 2534 55486 3725 5228 7939 572 2247 3624 PMC3730126__F1 Molecular mechanisms of cellular insulin resistance in muscle and liver 3667 7038 8694 84649 7352 4023 PMC3730487__F2 Two mechanisms of phase II xenobiotic-metabolizing enzyme induction by phase II inducers 196 4899 4094 PMC3731517__F6 Hepatic cholesterol synthesis and catabolism enzymes, uptake receptors, BA transport systems, phase II detoxification enzymes, and nuclear receptors investigated in this study 1582 1581 1593 3949 9420 4035 54658 6822 PMC3735949__F3 Comparison of gene expression in RAW264.7 (RAW) and TGEM cells treated with KLA for the TLR4 signaling pathway 23643 929 353376 148022 114609 4118 8772 11213 8737 51135 7187 3654 841 7128 6885 8517 3551 29110 5604 4793 5605 3665 3661 3663 5970 5966 108348016 5971 7124 3552 3439 3456 5743 4513 4843 7412 1506 PMC3735949__F5 A comparison of gene expression and lipid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the sterol biosynthesis pathway 6713 3156 4047 6309 1718 1717 9023 8435 1506 PMC3738954__F4 Key signaling pathways modulated by WNV infection 4615 8717 8772 8651 22861 6714 7189 843 841 6772 6773 10379 834 10454 637 3553 7187 842 64127 10010 7186 840 836 29110 23118 7205 7124 3661 3665 5597 4938 9636 4599 3659 6355 6352 57506 PMC3741284__F2 Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis 407035 3690 9575 10803 3676 1600 7536 2059 8038 3688 9144 331 225689 6938 5328 998 1385 3265 5979 3932 4781 10143 638 PMC3745259__F2 O-GlcNAc is involved in the cellular stress response 8473 10454 2932 3297 6667 2876 6648 PMC3746082__F1 Diabetes mellitus induced regulation of osteoblast 50964 57045 7124 5741 3357 2885 860 4256 PMC3746082__F3 Diabetes mellitus induced regulation of osteoclast 7124 729230 3570 6714 6850 2475 7189 100187907 2638 PMC3747540__F1 Emerging signaling pathways in hepatocellular carcinoma 7099 196528 9113 26524 4485 4771 64399 6608 PMC3752952__F1 Pathomechanisms of LN outside the kidney 717 1401 720 11277 9474 1378 355 1380 1773 7301 2214 2212 3654 3684 6775 3663 7128 59307 7124 51284 640 55024 2113 4067 10320 6772 9232 26191 25780 10318 7292 933 930 PMC3753466__F3 Skp2/Cks1 is induced by the TNFA/NFKB signaling pathway in nephropathy 7186 8717 5971 6502 PMC3753831__F2 ERK1/2-mediated regulation of the BCL2 protein family 673 572 90427 4170 596 2309 2002 PMC3754142__F3 Oncogenic and antiapoptotic functions of KSHV 4087 637 581 4193 472 6502 1019 PMC3754247__F2 Oncometabolites: linking altered metabolism with cancer 9817 4118 50 2271 PMC3756172__F1 Summary of AERD associated single nucleotide polymorphisms in the genes of immune response and arachidonate pathway 114548 5468 1636 7982 3565 80332 3596 64094 920 6539 2205 7099 929 3343 6582 7098 4056 7908 3567 140805 59285 6667 5732 10 5733 5734 5739 6247 57105 401190 PMC3756827__F1 Sirt3 deacetylation targets, and regulation of Sirt3 expression and activity 23410 3418 2936 PMC3757331__F8 Revisiting MPF activation 10776 983 4342 4661 PMC3759013__F1 Melanoma: New Insights and New Therapies 3815 4199 4893 2776 5728 673 10000 2475 596 PMC3759017__F1 Key mutational and therapeutic targets in melanoma 3815 4199 4893 2776 5728 10000 673 4286 PMC3759750__F2 Regulation of prosurvival and apoptotic pathways by ER stress 22926 7186 83939 842 468 836 7494 581 637 9695 PMC3760066__F2 Two TLR signaling pathways 929 4615 4118 7189 29110 3665 3661 51135 3654 PMC3761196__F7 Cell compartment view for network of lipid metabolic genes highlighting the role of SREBF1, THRSP, and ESRRA curated by ingenuity pathway analysis (IPA) 3952 9415 948 55937 949 32 6713 55902 1717 3292 50814 2194 31 2182 57678 10654 4597 79071 3157 6390 3417 2170 2180 47 1737 34 2224 3422 2222 37 3156 4023 51 1962 5515 5264 6720 5468 2101 7068 5465 10062 6721 PMC3761196__F8 This figure depicts a model of the lipid synthesis genes in the human mammary epithelial cell during secretory activation according to cell compartment 4023 19 9619 949 7436 55902 4190 2194 6576 47 2182 6296 32 3638 7069 6720 2099 51141 1622 23171 22937 2101 256356 55750 23175 2222 10554 8694 7498 9023 123 57678 696 7038 PMC3761885__F2 Proposed regulation of cardiac Per2 136 1956 8864 406 9575 4738 8454 6500 9978 PMC3763924__F1 Pathways of ICL repair 57697 84464 51455 22909 PMC3765067__F2 Map of molecular interactions involving GADD45 proteins and cell signaling pathways generated using Ingenuity Pathway Analysis software (IPA) 4803 7132 2885 4609 672 1386 5111 5888 PMC3765338__F3 Altered CREB/E2F1 signalling networks in co-treated HMCs 1490 6387 2114 7037 6319 1000 3949 1052 3726 133 2304 5468 5156 5925 3953 5997 4603 3397 1374 1959 1385 5606 2048 1906 2019 2247 19 6566 5054 8850 3148 3428 7153 176 983 2273 1869 11335 652 2167 3490 144455 3399 PMC3765962__F2 Important molecular pathways and drug targets in RCC 7428 2475 5230 2056 3939 2321 3791 2324 PMC3766375__F2 Fat side of Prostate Cancer 1583 1586 6715 3417 4199 2194 47 3156 4118 PMC3766957__F2 Cancer metabolism: fatty acid oxidation in the limelight 4199 2194 3417 5091 581 7352 7351 126129 PMC3767923__F6 Schematic of DNA damage response to double strand breaks 472 79840 3981 5591 7518 2547 7520 11284 PMC3769628__F2 Four current models of PARP inhibitor-induced cancer cell killing 672 5728 472 675 5888 PMC3775564__F5 Molecular network analysis of the miR-200 family and potential molecular targets with Ingenuity pathway analysis (IPA) 7036 3077 7037 220988 567 185 1616 9839 546 6935 10395 999 1487 1874 648 PMC3775871__F1 Epigenetic Regulation of SOX9 by the NFKB Signaling Pathway in Pancreatic Cancer Stem Cells 1950 4803 7039 4049 958 114609 7334 5336 23118 257397 10454 5970 2712 5971 1356 PMC3776718__F3 Overlay of the insulin-like growth factor-1 (IGF-1) signaling pathway with microarray data for comparison of very small embryonic-like stem cells (VSELs) with hematopoietic stem cells (HSCs) 3479 2885 4734 3717 3480 6774 572 6722 9021 PMC3777178__F3 Multifunctional phosphorylated PDZ proteins integrate signaling pathways to control hyperplasia, neoplasia, and cell metastasis 23513 5728 983 1017 PMC3779868__F1 Phosphoinositide signaling and its regulation by phosphatases 5728 3631 8821 5266 5163 3702 10125 PMC3781481__F2 Classic and alternative lipogenic pathways of fructose 3795 355 7038 271 50 PMC3782064__F2 Ingenuity pathway analysis 7187 55504 7473 27037 31 1054 5223 2731 3297 907 7298 140890 100507436 1050 3183 26574 23186 84619 3170 8812 91754 51013 5788 81628 10383 6928 26278 1743 55294 4287 4905 29990 4267 10274 29992 81035 9326 PMC3786574__F2 Molecular mechanisms of T cell co-stimulation and co-inhibition 29851 940 151888 1493 998 5879 2475 PMC3791171__F1 Molecular pathogenesis and mechanisms of thyroid cancer 4485 2309 7422 3091 7040 160728 7078 1612 7173 7253 PMC3792024__F4 Meta-Analysis Identifies NFKB as a Therapeutic Target in Renal Cancer 3627 6373 10563 6347 2920 5699 6892 3606 3660 6891 3600 3162 962 3589 9232 3665 3659 2022 2643 10312 7424 6422 10135 3574 4208 3107 960 54625 4982 29126 9111 129607 29760 4050 3134 64127 3106 5724 57674 3371 6772 3551 3431 355 9388 4938 27253 7412 7174 1475 834 602 8651 115361 7431 837 9636 1462 467 4312 5581 56475 7097 627 7098 5054 8743 54739 1119 4609 650 685 7091 6648 596 597 PMC3792429__F1 Hierarchy of nucleolar stress-induced neuroprotection 4691 4193 5728 2475 PMC3795364__F6 Schematic presentation of the influence of angiogenesis inhibitors on EC signaling 2833 5196 2475 4133 PMC3796213__F2 Connectivity map of NRF2-mediated oxidative stress response adapted from IPA software 4094 1384 2932 2936 9817 2730 7314 10961 PMC3797650__F1 Diagram of hedgehog (Hh) signaling in mammalian cells 4193 6295 8829 51684 374654 51715 1950 11197 91653 2719 8452 83737 6774 648 595 596 9429 156 6608 PMC3797807__F4 Cell Survival Following Radiation Exposure Requires miR-525-3p Mediated Suppression of ARRB1 and TXN1 2730 3190 5721 6401 2744 4609 931 7054 3313 637 7124 3329 8450 6197 3458 1543 5970 10935 7295 10576 5536 7157 408 3094 7178 10628 842 4217 727 2316 942 596 409 4843 3383 9978 1022 196 7189 972 4830 3554 9093 PMC3798018__F1 PLD and phosphatidic acid in the cell 2885 6010 6714 5338 5337 4026 5091 2475 7249 7248 6009 4831 PMC3799862__F5 Role of TRAF6 in RANK Signal Transduction Pathway 7189 2475 7188 7186 7187 23118 257397 10454 4772 PMC3805607__F2 Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks 55619 1509 10797 9516 2316 440 388 443 7305 6347 6472 4046 7040 1364 6876 5581 10038 5971 2149 29108 5341 35 3107 7097 1794 122618 6237 18 6774 9180 1075 3055 56922 1757 PMC3805607__F3 Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks 10659 249 5360 56954 7422 6678 4256 81693 1363 4067 327 885 4313 5590 6236 5970 5066 5426 3562 3077 5627 6404 9843 8858 3684 23600 55620 7054 3029 22921 29992 4082 2639 PMC3808153__F7 The 5S RNP Regulates p53 Homeostasis and Its Activation in Response to Nucleolar and p14ARF OverexpressionSchematic overview showing the central role of the 5S RNP in coupling the pathway of ribosome biogenesis to cellular proliferation 6135 6125 4193 PMC3808934__F1 RLR-mediated pathways of type I interferon and inflammatory responses 7706 7187 7189 5987 29110 8772 3661 3665 PMC3809064__F1 Targeting Mutant Fibroblast Growth Factor Receptors in Cancer 3552 6654 2885 10818 2549 867 PMC3811010__F3 Target genes of CDX1 and CDX2, and the BMP/TGFB signaling pathway 1045 1044 474 595 248 57818 894 338 10223 39 3486 3135 72 2984 9075 3560 5443 10551 6370 7358 9590 1191 1839 3630 25805 5111 9843 10170 3691 54576 4069 885 84666 54575 324 9314 6002 3918 1840 4316 1871 4760 50674 10434 795 7421 4583 2168 3205 7429 84911 6564 759 6476 10753 2063 3206 27035 4854 9154 5045 3218 158399 4922 25803 11337 999 4881 6514 5697 1015 8431 6663 7033 6343 7040 4838 649 655 7046 659 658 94 4086 10468 860 7908 5054 3726 3196 7045 57045 3725 8646 100188776 4681 55852 1746 3397 5328 2022 51450 PMC3815439__F13 MicroRNAs: molecular features and role in cancer 8772 23411 581 637 56616 PMC3817717__F2 Ingenuity Pathway Analysis (Ingenuity Systems, Inc., Redwood City, CA) of endothelial gene expression 23317 29927 2043 140885 6770 2081 5274 811 7494 1969 1025 29767 329 51752 54431 9370 1050 135138 7189 9641 3091 4609 2934 1627 5327 5269 3190 4670 4086 133 5340 4152 4052 2199 10492 7454 392 7027 5481 7159 527 4129 387 23779 5499 7168 29950 10919 6667 7170 26959 3725 472 2247 162 1725 80764 4665 PMC3820512__F5 Linking Transcriptional Changes over Time in Stimulated Dendritic Cells to Identify Gene Networks Activated during the Innate Immune Response 28964 4862 1454 9575 8863 8864 7329 1499 1453 8454 2033 9978 4193 5829 6612 5914 6667 8651 6774 6777 6772 6773 50808 2920 1380 7852 58191 6351 4790 4615 55620 3320 3654 400 114609 6850 7187 8772 66008 596 PMC3822957__F11 P60TRP signalling based on the results obtained from different systems including NSCs, PC12 cells and p60TRP transgenic mice 351 4851 1000 102 23621 4133 1020 PMC3823093__F4 Network analysis of proteomics using IPA 1738 1355 59342 4626 7137 4722 8735 3956 283571 4609 56999 3024 58491 9258 2064 5019 3857 6728 56241 29796 PMC3824005__F3 Canonical and noncanonical functions of the apoptotic machinery 207 23057 581 PMC3824029__F1 Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease 942 941 613 940 27040 920 6850 4067 3702 2885 695 2626 1386 PMC3825415__F3 FGFR signaling pathway 3535 1398 2885 867 998 1793 10818 3266 2549 6010 6461 PMC3825725__F1 Janus face of cyclophosphamide 7297 6773 1643 83667 10581 81622 896 581 3627 637 1026 3663 9246 4938 3665 969 8685 PMC3827506__F5 Signaling by innate immune receptors 6850 7189 114548 64127 4615 PMC3827841__F3 Protein-protein interaction network and SPIA analysis of the 28 up-regulated genes related to positive regulation of cell proliferation and 21 down- regulated genes related to negative control of cell proliferation 624 1839 6648 183 83992 133 7292 943 7049 146433 7040 5371 467 5154 9314 7046 2261 100 4804 1947 2246 3481 627 650 7857 23493 6909 6659 80781 9510 5578 8877 7052 4855 PMC3830525__F4 Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells 998 1958 5869 688 PMC3832246__F1 TNFR1 signaling of cell survival/proinflammatory and apoptosis pathways. Upon TNF receptor activation, complexes I (survival pathway) and II (apoptosis) are formed 7124 7128 4314 7412 3627 4322 7186 81858 8717 7188 7189 8772 PMC3835661__F1 Cell Death in Heart Disease 7186 8717 8772 PMC3835685__F1 Human epidermal growth fa ctor receptor 2 (HER2) signal transduction pathways 1950 7039 367 685 1839 3084 10718 9542 145957 5728 2475 85451 PMC3836075__F5 The role of Ang II and its metabolites in the adrenal gland vasculature 59272 5547 5550 PMC3837590__F3 Macrophage infiltration in adipose tissues, oxidative stress and IR 729230 3553 2621 4023 PMC3842443__F2 Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy 998 6010 5879 3082 2065 7249 7248 6009 3667 PMC3843161__F3 Biomarker-guided translation of brain imaging into disease pathway models 387 546 2888 5880 6156 63970 3507 5879 10913 6416 663 397 10051 1580 1676 79657 998 3606 8764 1630 6237 8737 5747 331 55081 5062 4792 637 7431 51283 2887 7024 5788 7157 5515 1107 1267 6385 10134 4067 7020 4582 5591 4791 2554 8682 5894 3791 860 8428 5338 843 4137 6464 4734 2534 5786 4689 55698 8301 154 60 10038 8615 10392 10000 6722 6304 8738 2781 2353 2596 1601 1832 23236 4000 5664 351 6774 119 7074 6731 55851 947 3689 2934 23005 2335 4155 4542 5657 5609 356 4316 PMC3844829__F2 Metacore™ apoptosis signaling pathway relating to TNF receptors, NFkB and BCL-2 antiapoptotic family genes 8784 8797 27242 8772 7939 PMC3844930__F1 Defining mitochondrial dynamics 56947 51024 664 6009 9927 55669 4976 581 4899 10013 PMC3847587__F5 Significantly affected canonical pathway “Interferon signaling”, as determined by IPA™ analysis 3458 3716 7297 581 3659 10379 6890 5696 PMC3849582__F1 Network Diagram of the single C 6188 6648 366 2033 6564 8678 PMC3855681__F4 An Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway 920 940 29851 1493 867 3932 7535 2534 27040 2885 3702 998 6010 5163 2932 8915 10892 3725 2353 3558 3567 3565 3586 1019 PMC3856238__F6 Global Proteomics and Pathway Analysis of Pressure-overload Induced Heart Failure and Its Attenuation by Mitochondrial Targeted Peptides 54539 4729 6389 6390 4709 4720 100 5464 7216 4716 51079 27068 47 4191 1743 55753 6392 PMC3859188__F4 Pancreatic cancer initiation pathway for simulation setting (III) 3845 30849 5900 369 9459 10000 5898 5604 5879 1147 572 842 10928 5337 598 4790 5594 1431 5599 PMC3861057__F8 Transcriptional changes in the WNT signaling pathway of E11.5 Sost–/–; Sostdc1–/– limbs 89780 7476 50964 25928 22943 27123 27122 6259 4040 4041 1855 998 53944 1453 387 1452 8312 2932 324 1499 7248 7249 2475 51701 6885 4773 6938 6925 6932 51176 607 6656 1487 595 1021 3398 894 4609 2335 2697 8313 860 960 PMC3862456__F3 Neutral AA transporters and activation of the mTORC1 signaling pathway 95 3667 5163 7249 7248 6009 PMC3863344__F2 Downstream targets of p38 MAPK 5080 4149 4609 2002 2113 6772 5914 3150 PMC3863464__F6 Putative CA-mediated inhibitory pathway of inflammatory signaling events 7099 7189 4615 3654 51135 PMC3863956__F1 Using PainNetworks to reproduce the NGF-TrkA signalling pathway 4803 6464 2885 50964 2549 3265 847 PMC3865857__F2 Main enzymes and G protein-coupled receptors in the cyclooxygenase pathway 4512 5743 4513 5730 27306 5740 6916 5226 5228 5729 5733 5732 5731 5734 5737 5739 6915 PMC3870072__F4 Subnetwork 1 and 5 of 6 networks in vehicle group 1244 5520 53358 7535 64407 6188 3276 2224 3082 9138 29760 6476 3725 2354 9112 1871 9219 25942 6223 5371 6667 6670 8170 63974 3611 6121 57716 3211 6230 3206 10682 6572 6232 3265 3106 8295 9736 1499 4215 85407 613 8444 PMC3871684__F1 Microfluidic Generated EGF-Gradients Induce Chemokinesis of Transplantable Retinal Progenitor Cells via the JAK/STAT and PI3Kinase Signaling Pathways 1950 1956 6464 5335 5578 6714 5921 5894 4214 5604 6416 5609 3716 6198 1380 3725 6774 6722 2353 2475 PMC3871865__F1 Photoreceptor cell death and rescue in retinal detachment and degenerations 8772 3606 841 637 842 114548 836 PMC3873541__F7 Enriched canonical pathways of miRNA target genes 3480 3479 2885 6464 3667 8660 2887 3716 5781 5747 5829 4734 5921 5894 842 4133 5604 6774 572 5599 6722 3725 2353 2002 9021 2322 383 4843 4332 4208 861 1869 5914 PMC3874211__F4 Network pathway analysis integrated the majority of proteins identified as changed on 2DE (), as shown in but did not include S-methyl-5`thioadenosine phosphorylase, and lamin B1 because of low scoring 5947 7415 10273 7167 1738 3064 337 3183 7417 5683 39 3172 5690 7416 141 5688 2744 6624 83988 56896 5706 4292 4043 57333 1809 7040 7284 3187 471 PMC3875667__F2 Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival 1017 1869 4436 5366 PMC3880642__F1 Smoking and microRNA dysregulation: a cancerous combination 1950 101 6868 7039 6714 1956 7099 5728 4193 2475 3091 572 2932 27250 1786 9353 1869 2272 4609 1021 3231 5962 387 5053 999 9839 6935 6502 PMC3882527__F5 Ingenuity pathway analysis (IPA)-identified top networks affected by Cd-induced oxidation of proteins 389 7167 476 1072 10487 11034 7431 1674 6282 824 2934 2317 6010 PMC3882864__F1 The variety of stimuli that can up-regulate NKG2D and DNAM-1 ligands 545 472 4277 100507436 5817 PMC3883350__F1 VIP tunes immune and inflammatory response by regulating multiple signaling pathways 7432 7099 3716 3717 6772 3726 3659 7124 6908 3725 4513 958 942 1493 940 5894 50943 3558 3458 3586 PMC3884200__F5 Effects of CYP2S1 depletion on mTOR signaling 2475 3479 3667 5728 5295 5578 5170 207 253260 3091 7422 84335 7248 6194 6009 7249 1978 1977 57521 54541 8408 9706 100034700 3551 7124 6794 92335 673 51719 PMC3887911__F2 Activation mechanism of Orai1 and STIM1 84876 27040 7535 7409 5879 998 6786 PMC3888473__F3 Top genes from SNP comparative analysis 4778 4609 3553 10599 10257 9429 4363 368 1565 10057 598 7124 1576 1555 1543 1548 1571 4780 5467 1579 4582 2308 9619 1244 3569 4843 1581 7498 5243 356 5743 1573 405 4318 7412 3082 664 1588 596 5111 7422 581 PMC3889250__F1 The BDNF signaling network 4803 4916 6868 5791 2890 399694 6714 53358 3717 4905 4688 140885 324 4792 3725 1938 2475 5970 4776 249 PMC3889256__F7 Rsu1 is a critical component for regulation of p38 Map kinase signaling from the IPP complex 6251 3611 998 8440 5058 1950 PMC3894150__F1 Central Role of the PPARG Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition 6517 6319 2194 79602 948 84649 9370 3953 5105 79071 2167 47 57104 3952 650 4086 23090 9611 51085 5468 23462 7480 1051 1052 1050 9612 7026 3638 7069 6720 8788 58526 PMC3895605__F2 Possible signalling pathways involved in enteric neurogenesis by a 5-hydroxytryptamine 4 receptor (5-HT4R) agonist mosapride citrate (MOS) 2668 4342 1908 2674 5979 1910 79002 2885 2549 10253 26153 5728 998 6010 PMC3898101__F8 Separate PI3K and Wnt signaling pathways 1499 8312 324 PMC3898811__F7 Schematic diagram as summary of the present investigation 3939 230 5230 4318 4313 6935 7431 79923 3550 PMC3903278__F8 Cofilin regulating actin dynamics and initiating HSV-1 entry 1956 6010 3984 6093 PMC3905281__F5 Wnt signalling pathway in developing muscle-less humeri 6423 27123 340419 84870 8532 79412 1499 2249 786 5309 5308 10216 23043 85417 6258 57611 3750 960 6299 57633 3714 333929 6939 9076 2043 64388 1993 PMC3906328__F1 IL-17 signaling and A20 3553 51433 64127 8887 26994 83737 7189 PMC3907060__F4 Analyses of differentially expressed genes regulated by fasting in all three tissues revealing an involvement of p53 and Srebp signaling pathway 22937 47 6256 31 355 1390 4827 23175 83667 39 4598 10654 4597 3422 2224 4047 55902 6647 6648 PMC3907121__F1 Cardiovascular Effects of Erythropoietin: An Update 2057 2056 613 3717 2885 6774 572 PMC3912166__F1 Establishment of HeLa Cell Mutants Deficient in Sphingolipid-Related Genes Using TALENs 7357 9334 9331 53947 8869 PMC3913761__F2 Emerging roles of store-operated Ca2+ entry through STIM and ORAI proteins in immunity, hemostasis and cancer 1950 6423 84876 93129 6786 PMC3913938__F7 Suggested mechanisms of synergistic cytotoxicity of [Gem+Clo+Ed] combination in lymphoma cells based on the previously reported data and our present results 842 8772 1386 836 841 PMC3917352__F1 Major metabolic pathways in tumour cells 3939 47 3417 3418 2744 PMC3919531__F1 The Intertwined Roles of Transcription and Repair Proteins 6996 472 7508 1069 5887 3014 7507 2177 84464 2067 55215 545 80198 146956 5111 7515 5888 675 PMC3922035__F5 Protein interaction network analysis of the up-regulated proteins in M 10492 2317 25874 813 1519 1191 7077 7431 4860 8039 PMC3923659__F2 Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer 9261 2002 4155 10454 3654 3656 23118 3552 3554 4615 7189 257397 3553 51135 54472 3665 3569 3458 4513 595 PMC3923659__F3 Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer 9261 2002 4155 3654 3656 3586 3554 10454 4615 7189 3553 51135 23118 54472 257397 3665 3556 PMC3928023__F3 Wiring and firing neuronal networks: Endocannabinoids take center stage 387 998 747 222236 221955 PMC3929010__F12 Reactive Oxygen Species in Inflammation and Tissue Injury 355 8717 7186 8772 581 3727 3725 842 836 PMC3930365__F5 Top ranked network of genes altered in the newborn lung at 24h post-O3 exposure 10797 324 9833 8318 1062 10926 898 29128 672 9918 899 10460 2177 10403 4288 23397 157313 9787 55215 6491 56992 PMC3931013__F3 Wnt signaling pathway represented by KEGG analysis 9350 7976 2535 8324 5881 8323 5330 11197 5601 7157 144165 4040 4041 5331 5332 57680 595 6907 6423 10725 2932 22943 6925 10297 4089 1499 324 83439 2033 59343 4776 4773 6093 51701 4316 6422 1387 PMC3931400__F3 Signaling by leptin, Wnt, and Beta-catenin in the regulation of Beta-cell proliferation 999 1499 5728 9021 2932 324 595 5308 6934 894 3667 8660 PMC3936406__F1 Molecular signaling pathways mediated by MET receptor tyrosine kinase in neurons 3082 2885 6714 6774 1399 5879 6010 998 2475 960 2549 558 PMC3937154__F5 IPA graphic representation of the network “Cell death and survival, DNA replication, recombination, and repair, cellular response to therapeutics”. Nodes represent genes and lines show the relationship between genes 6696 3481 9636 10234 8743 3486 8795 8797 64065 843 55034 3551 637 4892 836 58484 27113 5728 2232 367 8805 3661 898 5970 7157 10499 7528 7161 7832 6591 9988 672 7298 1643 5111 675 1434 26471 4292 5591 51065 55827 1647 5378 PMC3938256__F1 Genetics of lymphatic anomalies 7424 3082 147372 3680 3832 5784 5728 2475 5894 8517 2624 2303 54345 5629 2324 PMC3940357__F1 Frizzled homolog proteins, microRNAs and Wnt Signaling in Cancer 1499 11197 4040 4041 4920 6259 6010 324 51701 PMC3941591__F4 Top Ingenuity networks of genes whose expression was significantly altered in the hippocampus upon FST exposure 8737 7347 9135 23185 6233 50618 26986 9451 203068 8825 29993 124540 26994 51455 5929 5884 10923 5932 2237 86 4828 6010 9241 333 784 9501 56963 10825 134957 11343 9455 5864 6812 4090 4086 6845 8411 9810 7879 4087 4088 6657 7572 116986 5763 26036 4968 23641 55007 PMC3945331__F4 Modules identified by functional and gene expression enrichment analysis 6010 2353 2033 6622 4791 390 1387 7314 6804 4638 2670 161 3921 7052 7431 1674 5062 63908 9138 23164 10458 3337 920 2782 3064 7430 5590 23365 6667 8874 50964 5296 5216 8503 10915 9693 27338 1742 2778 23647 7454 3486 324 4628 4619 9459 7414 2934 3275 5962 8976 3611 1832 208 4627 4609 2932 2317 4666 PMC3945331__F5 Additional functional modules identified by ingenuity pathway analysis 1616 50964 3064 9459 1432 28996 4193 2534 2033 7791 5296 4149 8874 208 3691 5923 7414 8976 1855 324 4638 2017 2353 10000 5062 2934 10580 2475 134218 3337 3643 3301 1975 55735 6222 8189 273 5728 338 51726 1211 9146 7314 3329 573 7251 1173 5713 3093 9978 567 1387 2512 7295 PMC3950678__F6 Causal gene network inferred from top discriminative modules at a significance level of 0.005 471 275 2731 441024 1610 1757 2628 189 6470 1738 1629 36 27232 335 2875 6257 55902 1737 5468 4191 58498 8833 3398 93408 91734 50940 5584 151531 8867 PMC3950821__F3 Leveraging melanocortin pathways to treat glomerular diseases 6714 998 6010 2932 3553 PMC3952073__F4 TAK1 Regulates Hepatic Cell Survival and Carcinogenesis 10716 4087 4088 619501 4089 10413 1499 581 PMC3954580__F2 MEK5 regulation and downstream targets 627 4803 1950 3569 3976 6714 2353 6935 9839 6591 572 2309 PMC3954580__F5 MEK5/ERK5 Pathway: The first fifteen years 1950 3569 3976 6714 6774 6935 6591 999 1000 1499 4208 572 2309 PMC3959765__F3 RANKL-perturbed network and master regulators 6657 4149 3170 5970 4609 7076 7042 858 1000 1462 7431 7040 6925 3688 7043 5747 5054 7474 3091 6935 7291 10000 9020 2274 2335 6850 9846 3624 7048 3200 3213 7071 3219 3209 2627 7473 5451 867 6885 998 6714 7187 7189 1432 2113 5468 5080 3397 3569 7424 8829 7422 2026 6790 4221 6662 PMC3966557__F1 RGS proteins in the regulation of GPCR, PTH, and Wnt signaling pathways during bone remodeling 5741 846 64407 6002 8313 5997 6001 8490 1499 4772 PMC3969565__F1 Emergence and Evolutionary Analysis of the Human DDR Network: Implications in Comparative Genomics and Downstream Analyses 2074 5887 7508 11201 7520 2547 4929 142 10038 1161 1642 5591 7515 8451 2073 23411 84148 7507 2067 7518 79840 3981 23137 7014 80198 1763 146956 548593 80010 84464 7156 4361 116028 55775 51567 2177 641 57697 63967 5347 4437 4436 7465 2956 5111 1111 8454 8945 993 9978 6500 57551 50485 995 545 54962 7531 84126 8914 51366 10524 22976 4193 472 10155 11200 9656 6659 5595 9025 56852 8924 7334 6741 8554 51720 580 5932 8237 672 29086 55120 29089 11270 PMC3969803__F2 Summary of key changes in cancer metabolic reprogramming 3099 4199 2194 47 6319 3939 3417 7351 7352 581 PMC3969803__F3 Summary of the mechanism of several important drug candidates for anti-cancer metabolism therapies 3099 2194 47 6319 3939 7351 7352 PMC3974425__F5 Ezrin expression and cell survival regulation in colorectal cancer 1950 4318 4313 4323 7042 1630 7132 5879 7430 999 6714 598 581 5743 391 387 3725 1499 7157 2353 PMC3974997__F2 Interference with the host NFKB signaling pathways by STPKs of pathogenic bacteria: LegK1, OspG, and NleH1 1399 5971 6188 PMC3976587__F7 Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements 7124 7048 10673 7046 7133 7189 8717 7188 4615 54472 8837 10454 10010 3656 3654 8737 11035 8767 596 23118 92610 835 998 6789 841 5599 10370 9021 861 864 6667 1051 8743 3725 2002 PMC3976810__F2 Molecular pathways are altered due to modulation of signaling pathway in skin cancer 5111 4353 4842 3586 581 836 841 PMC3977192__F8 LTP pathway components and interacting proteins: response in hippocampus 1859 572 207 351 2353 63928 11261 5535 1827 2066 818 596 2905 369 5894 7054 1958 2475 6622 2534 1499 PMC3977809__F2 EGAN analysis showing all the differentially expressed enriched pathway genes 8688 80184 10592 80321 55031 8481 55125 7004 1058 2562 57697 2178 546 9126 641 79677 10224 7486 9559 348235 11102 887 5910 6373 64328 7015 84966 1440 5047 5443 23612 2247 51194 5783 23624 3861 5228 7412 10232 6441 10850 5657 2261 2056 1280 2520 9244 10763 6382 1271 2304 51214 6750 7177 2911 11081 392255 6406 90070 338386 4236 5550 63827 6342 440138 3998 259230 2820 91869 6905 84920 PMC3977945__F2 Simplified phosphorylation-mediated regulation of the core Wnt/Beta-catenin pathway components 4040 4041 2869 2870 54101 324 1499 28996 51701 23043 PMC3978512__F3 Canonical WNT/Beta-catenin signaling genes marked in green are hypermethylated in parous women (suggesting down-regulation of the gene in parous women) 11197 6714 3611 10454 5300 1499 324 4193 51701 3065 6925 4316 960 6422 22943 PMC3978517__F2 The replication checkpoint pathway activated following DNA damage 3014 11073 84126 545 993 PMC3978582__F3 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs 8837 2745 5311 6038 4082 7430 960 3162 633 1876 1958 150094 3672 4084 1385 1647 54206 55329 PMC3978582__F4 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs 10253 2934 867 4323 3099 1879 140885 3717 5782 7167 22936 9124 5121 4008 10549 64116 55501 5236 1396 26355 5214 PMC3980263__F3 The LNG1 data set 596 54205 1813 1950 4843 8503 2272 842 1030 2778 1956 203068 112 2885 1147 330 5566 4792 1871 6502 3845 6714 2776 6522 3156 9429 5598 8431 7157 387 27101 64840 51701 4040 59343 80319 26190 2932 57216 1387 4089 PMC3983448__F2 Molecular pathway for microsatellite instability+ gastric cancer 4292 3066 57510 6895 581 8289 5290 PMC3988961__F3 Pathway analysis 2520 4018 7216 1958 3727 467 55022 4094 7157 2633 22891 3725 949 PMC3989634__F2 Myeloid differentiation primary-response protein 88 (MyD88)-dependent and MyD88-independent TLR-4 signaling pathway 3146 7189 3654 29110 4615 51135 3661 PMC3991635__F6 Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells 2033 699 7040 9700 4193 545 5591 9184 2932 472 219972 4088 10744 6502 4089 9232 701 324 8379 325 1027 1028 7532 5111 896 894 994 902 85417 5347 999 25 5315 7465 5933 8556 8555 7027 11138 140739 PMC3994404__F2 KIT signaling pathways 3815 695 2885 5335 2886 8651 6772 6774 PMC4000238__F1 Wnt pathway and its interactions with other pathways in bone 5741 5745 4920 4919 324 3725 860 PMC4002842__F2 Network analysis of expression profiles of 10 μmol/L AA in HK-2 cells 4671 4350 2879 10365 268 5478 4050 5270 6689 4049 4055 5230 5106 3953 6364 4060 213 7351 2120 3038 3667 972 1508 6667 3718 5327 10544 7037 2920 5551 7170 4015 7157 10133 3665 6929 6289 3934 10148 3604 968 4215 50848 4520 PMC4005386__F2 Signaling networks for brain, lung, and bone metastases of breast cancer 3791 2534 84612 5879 5979 998 4690 9919 7203 7456 10694 4215 6124 71 3551 26227 2885 7431 4214 6228 2316 6208 6232 7529 7534 10788 4194 26993 2033 8517 4193 994 993 10657 5970 3065 4152 4793 2091 7157 6839 1869 3066 5966 4790 PMC4008712__F1 Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood 8651 2885 867 369 3101 5605 5594 2872 6720 PMC4012154__F1 Signaling pathways involved in microglial phagocytosis 54209 4615 6850 51135 998 PMC4014913__F2 Metabolic pathways of fatty acid (FA) and triacylglycerol (TAG) synthesis, and mechanisms by which lipid intermediates affect hepatic insulin sensitivity 3667 8660 2475 4018 355 79071 PMC4015186__F1 MiRNA Regulation of the Human Glycome 79868 29929 440138 84920 23193 56052 7841 10195 1798 4248 5589 25834 11253 79158 84572 4247 51172 PMC4016715__F3 Model depicting ciliary cargo trafficking pathways 27031 403 6102 84100 90410 9094 5108 80184 585 378 6103 PMC4019002__F1 Omega-3 fatty acids and dementia 3416 3479 3643 5163 5164 572 2002 PMC4019579__F8 NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages 10135 7099 998 387 6010 3985 PMC4020801__F3 Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration 7276 23109 213 79051 5265 2243 3273 462 5730 2878 PMC4022194__F2 Signalling pathways that were altered in the high serum group 24137 9133 9748 9787 57405 324 56475 10403 144455 991 5426 6790 PMC4022581__F4 Transcriptome Profiling of the Theca Interna in Transition from Small to Large Antral Ovarian Follicles 7373 7148 4053 4052 3486 2487 4072 960 1001 5791 857 4915 290 1316 9388 84898 55801 7124 5010 53832 10099 483 3588 80381 6542 3383 219736 7316 596 54518 51070 2052 54997 316 10 57705 9915 PMC4026009__F3 Network-Based Kernel Machine Test for the Identification of Risk Pathways in Genome-Wide Association Studies 6927 3174 5080 2645 50674 3170 3651 3172 5313 6514 5078 3175 6928 389692 3630 3171 4760 3375 3280 2494 4893 673 595 7157 1026 5925 572 1019 4193 PMC4026869__F6 Gene network of 32 genes with pathway level expression change and mutation via GeneMANIA 6502 1962 5291 1947 1308 26060 1832 208 10000 1956 673 2885 27085 6135 5609 4193 7430 6416 5328 3265 7249 6197 3551 5155 3710 4478 7057 117154 PMC4034385__F1 Chromatin modifications as therapeutic targets in MLL-rearranged Leukemia 84444 80237 22936 23476 404715 PMC4039002__F9 Aggregate-Prone R120GCRYAB Triggers Multifaceted Modifications of the Thioredoxin System 3630 1410 8841 9531 PMC4039991__F1 Upregulation of a Steroid Synthesis Pathway in Th2 Cells In Vitro(A) Schematic representation of integrated steroid biosynthesis pathway with abbreviated metabolites (black) and protein factors (blue) 3157 50814 51478 3156 4598 7108 1718 10654 10682 4597 4047 6309 2224 6713 1717 2222 3949 6770 134429 706 1583 1586 6908 PMC4040584__F1 Expansion of the SDF-1/CXCR4 migratory signaling network in breast cancer stem cells 7852 5783 5784 5782 5499 5500 9874 1018 1022 375449 1198 5605 10564 4650 3691 7431 PMC4041745__F6 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome 1956 2241 2534 2886 7074 998 5906 387 9475 3985 6010 10743 5058 PMC4046566__F2 Application of the algorithm to identify TNBC-associated genes 6457 2099 9568 547 149428 596 9862 6091 5469 6624 56144 1104 5347 3159 5914 7088 4862 4036 6362 9722 23532 5915 2625 6496 11113 7431 4678 2064 2175 1062 PMC4049685__F2 Colorectal cancer metastasis signaling pattern 1950 978 1956 2885 408 3845 1855 5900 4087 6010 85451 572 1874 7908 3725 4609 4513 PMC4049860__F3 CCM1 and the second life of proteins in adhesion complexes 1499 4040 4041 324 PMC4049863__F3 Rho-GTPase signaling in leukocyte extravasation 3383 387 1003 PMC4052302__F10 General overview of TLR4 signaling in humans 7099 7189 23118 3661 10010 7187 4118 4615 51135 PMC4053266__F3 Integrative pathway analysis 7006 100124696 399 7852 5175 3385 3383 7412 4286 5077 6663 387 596 1638 PMC4053506__F8 D-PDMP inhibits ox-LDL induced LCS activity and atherosclerosis development 4280 19 1581 3156 4023 6720 948 6721 PMC4055861__F2 Base excision repair (BER) pathway 7374 6996 4968 79661 8930 4350 252969 55247 5423 2237 7515 3978 PMC4060077__F1 Molecular switching from apoptosis to necroptosis 7124 8772 192111 581 197259 PMC4061726__F1 Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease 4920 6259 324 998 387 51176 4041 55366 8549 59352 PMC4063500__F2 Lithium’s autophagy regulation mechanism in various neuropsychiatric diseases 3630 2932 2475 PMC4064254__F2 An atlas of genetic influences on human blood metabolites 130013 3990 348 635 875 10101 189 3992 257 5723 239 26227 6319 4363 6583 1636 56172 49855 196743 1071 1312 8972 1384 5625 10019 2646 2678 410 54716 290 26873 27165 5053 1644 2328 137872 135293 10257 1890 2766 PMC4065631__F2 Ligand bias prevents class equality among beta-blockers 367 383 384 PMC4068945__F4 Nrf2-mediated oxidative stress response pathway is altered at multiple levels by DNA methylation in COPD airways 5728 2932 9817 8452 9978 3727 4097 2495 2944 316 2052 PMC4069163__F6 Correction: De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response 1493 27152 3932 962 867 2534 7535 952 27040 3702 2885 1019 8915 29851 940 PMC4069681__F1 Rho protein GTPases and their interactions with NFKB: crossroads of inflammation and matrix biology 3458 3553 3383 958 940 613 8717 7186 388 998 387 5879 6093 4214 399 5881 PMC4070062__F1 TLRs and autophagy 7097 7099 51284 4615 10392 64127 3665 54106 2241 PMC4071059__F3 Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets? 10716 2885 4087 4088 5163 4091 7249 4092 6009 4089 2932 2475 29904 1977 2002 2626 PMC4071201__F1 Depiction of the systematic procedure to study drug resistance in MM 7039 3479 7099 1956 7189 3667 7186 2885 5163 4214 6885 2475 581 PMC4071401__F11 Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis 8829 4128 3091 7422 999 7291 PMC4076815__F1 Typical PDA cell is depicted showing schematics of representative metabolic pathways that are altered in the disease in response to oncogenic Kras 3098 3099 6120 22934 2673 2744 4199 4190 2805 2806 PMC4081676__F1 Protective role and partial mechanism of peroxisome proliferator-activated receptor A in alcoholic liver disease 5465 7040 847 948 26291 23411 7351 7352 PMC4084493__F2 Non-homologous end joining: emerging themes and unanswered questions 6741 1763 9156 7515 472 675 5888 11284 545 84126 7518 PMC4085347__F4 A mechanism showing tyrosine kinase receptor induced regulation of Nrf2 nuclear–cytoplasmic shuttling under redox homeostasis conditions 2932 6714 4067 PMC4086823__F1 Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage 472 4193 581 331 836 842 PMC4090103__F2 Virulence Strategies of the Dominant USA300 Lineage of Community Associated Methicillin Resistant Staphylococcus aureus (CA-MRSA) 10290 23237 383 PMC4092039__F1 G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin 92359 4485 60485 154796 9113 26524 999 23513 PMC4092857__F3 Activation of the DNA damage response upon CDT exposure 545 472 993 995 1019 1017 983 581 84126 PMC4103158__F3 Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns 7136 4633 4626 4624 1674 7168 7125 7169 7140 4703 4635 8557 4621 4632 88 7139 4634 4606 7170 1756 7171 7135 7431 1636 3155 549 3030 10449 1629 593 3712 4191 1431 50 2271 3418 6389 6390 8802 8803 1738 2110 PMC4107940__F1 General interplay between the canonical TLR signaling pathway, the cytokine-mediated DNA repair feedback loop, and the growth factors-mediated signaling pathway 3146 3717 2885 114609 4118 6772 6774 6775 4615 2067 7507 7515 7520 2547 4968 5888 672 7298 5423 PMC4111923__F2 An example of a CN: the EGF signaling pathway includes > 60 proteins and has several alternative pathways (from http://www.sabiosciences.com/pathwaycentral.php, where many other networks are also shown) 1950 2064 2885 2549 999 4582 1956 6772 2059 3716 3717 5879 9046 6774 5058 6010 5163 5868 1445 2002 PMC4112878__F1 Endoplasmatic reticulum stress caused by saturated free fatty acids 572 638 581 22926 PMC4113076__F7 Comprehensive and High Resolution Genome-wide Response of p53 to Stress 7508 1643 9412 2512 8242 8473 5429 5111 51150 10432 1263 57050 4193 5914 5889 83667 6385 27085 5825 50484 9618 283459 PMC4113681__F1 Representative regulators of the Sprouty cellular content at transcriptional and post-translational level irrespective of the Sprouty isoform and cell type 867 2549 6478 1398 1499 387 5879 998 1431 4609 2885 PMC4115674__F1 Ras/MAPK signal transduction pathway 6654 2885 867 1431 4763 8036 161742 673 PMC4116492__F1 Targeting FANCD2 for therapy sensitization 1019 2177 472 545 PMC4117641__F5 TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in ABeta-Expressing Caenorhabditis elegans 25843 6950 8428 10694 907 60 PMC4120774__F9 ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC 324 1499 4609 595 PMC4123081__F1 Simplified schematic representation of the extrinsic and the intrinsic (mitochondrial) pathways of apoptosis and necroptosis 7186 8717 8772 637 581 2021 PMC4123468__F7 Reactive Oxygen and Nitrogen Species in Steatotic Hepatocytes: A Molecular Perspective on the Pathophysiology of Ischemia-Reperfusion Injury in the Fatty Liver 8717 7186 8772 637 581 PMC4123471__F6 Extracellular Matrix and Liver Disease 8480 596 581 PMC4123572__F6 Putative inhibitory pathway of the Cp-BF-mediated anti-inflammatory response 7099 7098 7189 4615 6850 6714 5163 PMC4125180__F3 Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis 3485 929 6263 2669 51330 384 388 4502 2326 PMC4125356__F7 MicroRNA miR-150 modulates the expression of GAB1 and FOXP1 that are involved in BCR-signaling pathway in CLL B cells 613 933 930 4067 29760 5336 2549 6850 27086 PMC4126105__F1 Proposed integrated model for tissue-type plasminogen activator (tPA)- and plasminogen (Plgn)-mediated modulation of blood–brain barrier (BBB) permeability during thrombolysis in ischemic stroke 23556 3949 5156 729230 PMC4128536__F4 STRING analysis of pathway enrichment and interaction in the altered mRNA in rat ARDS 1879 871 3982 23491 2264 2560 7103 4190 5685 1528 324 3489 3938 50 6275 210 27102 4504 6648 7076 2796 9588 2812 10266 10449 3934 6280 PMC4130149__F4 Schematic overview of TNF-Alpha-induced signaling pathways to activation of NFKB (a), apoptosis (b), and necroptosis (c) 8737 8717 8772 23118 6648 11035 197259 PMC4130844__F1 Signal transduction and immune response in Helicobacter pylori infected gastric epithelial cells 7099 6714 2885 581 10392 5058 3725 2875 27035 2002 3569 3383 PMC4132269__F2 Vascular inflammation, NK cell/monocyte crosstalk and angiotensin II in cardiac ischemic injury 958 7412 729230 962 10743 100507436 3383 PMC4133513__F1 Toll-like receptor signalling 3929 929 7100 4615 4118 7099 54106 51135 7098 3656 7189 7187 3661 3665 PMC4135953__F10 The gene-to-gene networks of TLR3, TLR4, and poly(I·C) in mice immunized with UV-V after SARS-CoV challenge 5329 23645 3659 2920 50506 929 4057 84807 8013 2069 7057 6004 7099 114548 324 6772 9518 133 5996 4283 54210 115361 2634 5054 4001 958 22822 7850 PMC4143352__F5 Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease 718 716 721 720 727 719 1380 1378 730 729 735 3689 3687 PMC4143352__F7 Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease 721 5582 84898 714 10636 3350 10580 3635 3689 712 6556 3398 3693 3687 53822 719 10563 7805 5341 3725 7305 2670 1535 5788 1267 3071 3394 7097 5453 54209 1043 28514 10871 968 441478 1524 3162 567 4478 1520 9308 64236 377 6774 6348 2044 23568 1510 7391 1522 1509 3106 6720 3751 5641 19 5476 1508 7108 9180 445 64130 1200 2799 PMC4146420__F1 Prostaglandin synthesis pathway 246 239 240 4512 5226 PMC4148087__F2 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention 5156 3815 5728 4763 5894 23035 1846 7248 6009 1975 1017 1499 PMC4150215__F7 CREB-dependent cell cycle factor expression signalling network in GBM tumour cells 595 891 5111 PMC4150834__F2 MC1R, the cAMP pathway and the response to solar UV: Extending the horizon beyond pigmentation 156 2870 409 4893 4286 4157 PMC4159787__F3 The relationship between RAGE and neurite outgrowth after spinal cord injury 3146 6285 998 PMC4160336__F4 Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host 998 6010 10392 PMC4160341__F3 Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells 387 983 5058 1894 8874 PMC4163606__F1 LIF signaling and post-translational modifications of some stemness transcription factors 3976 7341 6774 6657 79923 688 22808 9021 PMC4165418__F4 AKT suppresses the HR pathway and activates the NHEJ pathway via many mechanisms 472 9025 9656 672 9156 5888 PMC4166537__F4 CCR-14-0330R1: Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer 84181 23345 287 472 4036 288 79633 7862 10735 3910 85407 2033 114788 7157 10076 5925 1956 8029 5266 23524 8295 2618 1653 7403 55759 6205 79026 PMC4167640__F2 Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment 23513 6010 60485 4485 84962 7791 4771 999 92597 55233 10207 154796 9113 23558 28996 5784 PMC4169022__F3 Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma 1511 6000 90952 5105 1959 55588 2115 5345 7450 5473 5443 2908 8202 187 11213 7305 140885 1191 2778 3635 5729 6605 9612 596 10846 3707 3608 6258 5142 2864 5737 6870 411 10051 991 80152 3660 6672 571 26278 1058 3161 960 55055 PMC4171211__F11 Proposed model of tetrandrine-induced apoptosis in prostate cancer 355 8772 581 637 PMC4171766__F2 Top networks observed in Ingenuity Pathway Analysis (IPA) 5337 6867 8462 10664 23052 1831 22926 55422 10847 978 171023 6205 114625 25831 126669 4664 PMC4172779__F3 Downstream genes chosen from KEGG annotated in Wnt/Beta-catenin pathway 51701 9350 4040 4041 324 4089 4088 25805 50964 6477 6500 8454 2040 387 9475 PMC4172957__F5 Expression of genes in the Th1 response network and interferon signaling pathway 602 3269 4340 10461 3146 5295 3458 3717 7297 8651 100653365 3437 5696 10379 PMC4185881__F1 Formal Modelling of Toll like Receptor 4 and JAK/STAT Signalling Pathways: Insight into the Roles of SOCS-1, InterferonB and Proinflammatory Cytokines in Sepsis 3929 929 4118 4615 3654 29110 3550 7189 10454 23118 3661 7099 PMC4186798__F6 Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression 999 2475 596 581 891 1019 PMC4189729__F1 Synthetic lethality as a therapeutic strategy for the treatment of MMR-deficient cancers 2956 4436 4437 PMC4191269__F1 Controller composed of the KDEL receptor (KDELR) and the Gq and Gs signaling pathways maintains the homeostasis of membrane transport at the Golgi complex 6714 1385 6667 466 467 1386 PMC4192477__F2 Numerous proteins that interact with core components of the NOD2 and MAPK signaling pathways were identified as regulators of IL-8 secretion 682 64127 11214 8569 83737 5338 8767 843 57506 554 22900 7088 5518 84674 790 5595 11221 1432 4642 8030 4638 55072 5519 5747 7323 995 3065 672 122953 1843 5300 8945 5371 5970 7534 6615 653361 1386 7015 57478 23408 472 10856 2000 25942 1999 134728 80279 54951 7332 9325 29099 PMC4193347__F6 Germline PTEN Mutation Cowden Syndrome: An Under-Appreciated Form of Hereditary Kidney Cancer 3082 5728 96459 57600 7249 201163 7248 7942 4286 7030 6009 2271 6391 6390 6392 7428 PMC4194125__F8 Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer 154091 1738 1737 3091 2271 3417 6510 8140 81539 6389 408 PMC4194559__F1 Presents an overview of the Rho/Rho-associated protein kinases signaling pathway 6010 998 6093 9475 4133 PMC4196580__F6 Toll-like receptor signaling pathway showing the annotated and non-annotated proteins 7097 5879 54472 114609 8772 3929 929 23118 51135 8195 7189 958 923 1513 130749 54106 7098 PMC4197041__F1 Getting ready for building: signaling and autophagosome biogenesis 5163 7248 6009 8140 7249 8408 7189 4615 83939 9846 2885 7099 6774 1956 PMC4197875__F1 Hippo signaling pathway in stem cell biology and cancer 122786 4771 10207 154796 6010 7791 4485 2196 120114 79633 9113 26524 55233 150094 23235 23387 4139 4140 2011 57787 166824 9344 51347 57551 3535 23513 5784 5077 999 PMC4198693__F5 Identification of molecular pathways that are altered by Atbf1 inactivation in mouse prostates 55388 478 152831 64375 10062 463 3909 55061 8817 2548 1992 5918 440 79017 255231 23397 84706 6583 2028 2908 4070 26298 196 11057 22926 4099 PMC4202122__F2 Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions 4582 1956 1499 2885 11031 23636 PMC4202272__F1 RANK signaling pathways 126014 4791 867 7187 9846 7186 7188 6850 7189 695 7006 100124696 10454 169200 4772 4286 PMC4208312__F1 B-cell receptor (BCR) and its downstream pathways 613 558 5728 29760 6850 4067 695 5336 10892 8915 2475 930 974 973 PMC4208312__F4 Multiple event model for B-cell lymphomagenesis 613 558 5728 29760 6850 4067 695 5336 10892 84433 8915 2475 930 PMC4208677__F4 Ingenuity canonical pathway analysis 3458 2175 2176 6772 2178 545 472 2189 466 2177 675 580 672 5888 5347 571 4292 641 4361 4436 3929 7189 3716 7297 6774 9021 6667 1230 384 3566 1234 7124 PMC4216471__F4 The molecular cascade downstream of Nodal and Activin A signalling in EpiSCs 4838 83881 93 91 130399 6997 92 90 145258 8928 8320 387 7852 2626 64321 3170 2932 3399 3398 595 1499 999 6591 3475 2335 4313 PMC4216940__F2 Majority of mitochondrial proteins/enzymes undergo reversible lysine acetylation 37 1892 95 1431 3030 10449 2271 2110 7381 PMC4220839__F2 Cytosolic DNA recognition pathway for IL-1B production 64170 10111 9447 3553 PMC4221383__F3 Developmental Pathways Activated in Melanocytes and Melanoma 1906 1910 5894 4117 PMC4221415__F5 Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics 3845 64098 29780 3987 817 92335 1432 8986 55589 818 197259 3985 51135 3984 7525 3815 2444 5753 2049 5564 5562 5571 5747 7145 2241 5563 5565 2011 673 7465 5601 65975 8621 10746 4214 11140 7534 7532 11200 7076 217 10250 9641 7531 7529 9967 216 10606 64087 448834 54474 79026 3849 7276 388697 1667 3858 1633 5471 219 29937 3094 2235 8854 6426 4833 10493 6427 79139 9476 3850 7965 55679 7273 27 5604 816 7006 100124696 6790 11213 1956 6850 4921 2041 25989 1445 10420 120892 3320 3326 1453 9113 23524 10716 2580 10010 64343 11035 4282 4835 132 51540 96626 54749 10923 9669 PMC4222910__F6 In Vitro, In Silico and In Vivo Studies of Ursolic Acid as an Anti-Filarial Agent 948 929 114609 4118 3654 23118 5606 5608 1326 1385 PMC4223653__F2 Neurology of mTOR 1950 3479 627 5728 4763 5163 2932 7249 51256 7248 6009 8408 9776 PMC4224695__F3 Interactions of Acvr1b with other proteins in primary infection 5356 867 4666 2099 405 6774 10490 7275 5935 9641 5683 4193 8533 3297 4099 4976 8678 6642 6643 6462 7011 93 7431 11059 6247 94 4087 10763 5092 9733 PMC4229533__F1 Pancreatic cancer cell survival pathways in 5-fluorouracil resistance 1950 998 2885 2932 324 6714 6774 1499 572 5728 2475 581 PMC4236746__F3 Largest key pathway obtained for the colorectal cancer case study 84966 5782 8328 1822 4753 3725 5747 8148 2130 9935 5295 1179 6002 4887 867 4803 958 4747 1937 22986 4744 5594 10563 PMC4240271__F1 Post-translational regulation of TGFB receptor and Smad signaling 64750 57154 11059 9146 9958 83737 1601 25805 4092 10450 331 1003 7189 4089 5163 11171 960 442912 442917 9475 6497 PMC4240652__F8 Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet 1493 3932 962 867 916 2534 324 27040 10451 3702 2885 5530 3558 3565 7124 1019 8915 1610 940 PMC4246083__F8 NLRP3 regulation by GPSM3 3603 63940 7175 114548 3553 PMC4249087__F8 The UPR-induced HAdV infection boost by GCA 25801 22926 406952 717 727 PMC4251064__F4 Canonical pathway of TP53 signaling: dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) 545 4194 5371 11073 64065 355 2765 5728 4193 54549 57103 PMC4252624__F5 Glutathione peroxidase activity pathway which was significantly altered in the liver of female LMB, obtained from GSEA, featuring GO terms 2879 240 2878 7295 836 847 2882 2876 2952 4259 373156 581 3569 9588 2877 207 PMC4253844__F1 Cholesterol in brain disease: sometimes determinant and frequently implicated 3156 1718 1717 10577 4864 PMC4257089__F1 In silico modeling of a CD4+ T-cell 1956 660 6714 7046 695 1445 2706 2099 360 5770 5781 367 4804 5777 5728 6955 3643 10825 4846 5743 351 858 5338 940 857 3932 2885 27040 998 5894 8915 6464 3702 PMC4258093__F3 Canonical Wnt signaling 324 8312 1499 PMC4259449__F5 Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways 9891 170712 10658 6844 7161 7037 7454 57185 6419 197259 1022 4035 PMC4262241__F3 Network enrichment analysis of point mutations in genome TCGA-02-0014 7409 3417 23345 8639 51643 23037 80835 64881 3939 5728 5598 1441 3689 4892 1832 667 4914 4292 25865 27148 6514 4330 29110 53335 675 1956 5156 10188 5601 5591 4803 7391 5159 5295 5602 114788 PMC4262781__F1 Aberrant miRNA expression in liver cancer promotes cell-cycle progression 4087 4088 4193 4609 4089 5111 1021 1019 1017 983 5925 994 995 993 1869 PMC4262781__F2 Aberrant miRNA expression in liver cancer affects the functionality of apoptosis pathways 1021 1019 1017 4609 5111 983 841 355 637 4193 596 581 842 836 317 4170 545 472 7249 5728 3486 64326 900 PMC4264984__F5 Putative mechanism for EGCG-conducted cardioprotection against H2O2-induced oxidative stress through the Akt/GSK-3B /caveolae pathways in cultured H9c2 cells 2023 8821 10549 6389 217 4942 27067 3190 857 2934 595 PMC4267483__F1 Noonan syndrome 3845 867 3265 6654 5781 2885 673 5894 8036 PMC4270387__F1 Examples of non-stress-related peroxide signaling 4015 1583 1431 1950 6770 1584 3091 57716 4018 PMC4272565__F6 Breast cancer pathway 472 545 3014 9212 1018 27127 672 641 PMC4272576__F2 Candidate genes influenced by Zn2+ or involved in Zn2+signaling and metal ion homeostasis associated with the development of ASDs 22941 85358 150684 4520 PMC4273126__F3 Molecular mechanisms of alcoholic fibrosis 1571 6890 4088 6667 4312 PMC4276042__F1 Targeting the PI3K pathway for cancer therapy 5163 5728 4193 2932 7249 7248 572 581 595 6009 5879 387 1977 PMC4276889__F6 Reduced HIF-1A expression in TRPM2-S-expressing cells determined by proteomic analysis 3091 2597 2026 3308 637 3939 230 4869 7431 7019 7037 PMC4277084__F3 PPAR signalling pathway 3158 5360 4023 4312 7350 3611 7316 364 PMC4278533__F4 Gene set variation analysis of the antigen processing and presentation pathway (APP) and the natural killer (NK) cell gene set 3458 6892 811 821 1508 920 4261 6418 1524 79156 3560 5551 114879 1240 57595 10578 9022 55501 430 4684 PMC4283216__F1 GSK-3 family as therapeutic target for myocardial diseases 3611 4087 4089 4088 4091 387 2931 324 5163 1499 1869 4092 4609 PMC4284697__F1 Summary of the p53 pathway 4193 1647 1643 581 2176 9997 4436 5371 83667 57103 PMC4284744__F1 Fibroblast Low-density lipoprotein (LDL)-related protein-1 (LRP-1) signaling in renal fibrogenesis 4035 3611 572 PMC4286392__F9 Notch and Eph / ephrin signaling pathways of non-myelinating oligodendrocytes relative to corresponding ones of their myelinating counterpart 55959 6387 7852 4756 4851 5979 411 285362 1565 549 10733 51552 57162 6598 429 23493 6595 6604 4830 2959 2963 440 175 8997 PMC4287242__F5 Signaling pathways associated with capacitation-related proteins 84519 5584 49 5862 5162 2597 8548 6667 3382 335 26256 6648 4843 114822 2879 8803 PMC4290680__F1 Structural model of and cell signaling pathways triggered by ManLAM and its biosynthetic precursors LM and PIMs 7096 7097 7099 929 6850 4046 114609 8844 4615 51135 64170 3656 3654 10892 7189 8195 828 3725 3586 4351 PMC4291046__F1 Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway 3551 7124 8835 8651 3569 3586 3565 5728 7249 7248 207 2475 PMC4292165__F3 RLR Signaling pathway 7706 1540 7375 54941 7187 29110 PMC4292778__F4 Gene network analysis of top HHT associated genes 4673 5272 100506742 5074 231 835 55024 4899 81848 85451 8772 1879 875 10935 79966 7188 57379 23409 10228 PMC4298363__F7 Suppression of ghrelin signaling mitigates age-associated thermogenic impairment 2693 3667 7350 4976 9927 4513 PMC4300045__F3 Gene ontology (GO) analysis using the DAVID software 1017 472 545 2242 637 4609 581 842 836 4193 64065 7249 5728 64326 PMC4303254__F3 Gene product interaction network of immune and inflammatory responsive genes associated with smoking in females generated from the information in the Ingenuity knowledge base, version 7.6 2162 201625 51142 3172 5087 26052 10316 5196 4638 9047 4603 11107 51348 1191 57823 2915 5729 5154 7294 5627 1233 2149 23205 650 356 2838 9628 3939 3001 8111 2885 80237 2939 25924 51560 5874 2781 90102 10112 9231 3820 11098 10202 6915 9437 9254 5577 10219 10417 4199 10578 5730 26053 5521 54498 8320 4058 84519 5621 2681 57732 PMC4303322__F4 The mammalian DNA damage checkpoint pathways and/or systems 545 472 3364 5884 84126 11073 672 9656 PMC4304881__F5 Summary of results of RPPA analysis of EGFR signaling in MCF‐10A + EGF, MCF‐10A + AREG and SUM‐149 cells 3678 2335 6714 3688 3611 22943 5728 2932 324 9846 5163 2475 2549 253260 2885 374 1956 7248 6009 6774 7249 10125 3265 4893 4342 2194 PMC4312878__F3 Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond 6774 3182 6352 102659353 4513 3606 3603 PMC4314529__F1 Mechanism of ICL repair in the FA pathway on collision of a replication fork with an ICL 84464 80198 22909 672 7398 PMC4314580__F4 Treatment strategies for inactivating EBV infection or EBV-associated oncogenic pathways 4067 6850 613 4193 PMC4317900__F1 Disease-specific mutations in B-cell lymphoid neoplasms 114609 4615 6850 695 29760 4609 5728 51135 3654 84433 8915 7189 3399 10454 23118 896 4193 2475 673 11319 973 PMC4319431__F1 Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions 999 8772 7186 8452 2591 79623 2525 2528 637 581 331 PMC4320821__F4 Network graph showing interactions between ID2 and ID3 and their MIC-inferred ‘target’ genes regulating cell death 9314 595 5295 1387 5970 1390 4613 4609 3687 11221 4149 2353 6667 5743 3725 4778 3398 2999 5583 7295 5606 596 7057 6477 5515 1845 3399 54205 3482 3002 8717 7157 637 6613 1844 7431 6612 1386 7528 PMC4324359__F2 Differentially expressed gene enrichment of the top scored pathway maps 9451 22926 7494 581 7186 5611 847 468 3725 637 PMC4325931__F6 Overlay of gene expression on the p53 signaling pathway 4193 7157 581 2810 1019 355 94005 64065 637 317 PMC4328972__F1 Metabolic disturbance in the diabetic heart and prospective therapeutic targets 355 7099 114548 5465 PMC4330253__F3 Illustration of molecular pathway for significantly associated single nucleotide polymorphism (SNP) loci in the metabolic syndrome genome-wide association study (GWAS) 6364 8915 348 29775 3619 1062 9212 4255 11130 9183 79003 64946 PMC4333457__F6 Proposed human innate immune signaling pathways activated during V 3605 7099 3466 4615 7297 3716 6773 6772 5008 10379 7189 3934 1667 6279 6280 6774 4353 83481 4843 837 114548 834 10562 3593 PMC4339278__F1 Inflammasome activation and cross-talk between endothelial cells (ECs) and macrophages (MØ) in atherogenesis 3949 834 3553 948 7412 3383 114548 4615 PMC4344782__F10 Alzheimer-related protein association network in AD-iPS26B neurons 1347 1345 1340 1337 4725 4696 1350 4724 4708 7384 4701 1329 4706 4695 4711 4709 1537 4697 1349 4718 4700 7388 4713 4729 7386 4712 6389 6622 2597 351 2932 8883 805 808 488 PMC4344782__F11 Overlapping Alzheimer-related protein association network of AD-iPS5 neurons and of AD-iPS26B neurons 4696 1347 1337 4695 4701 1345 4709 1350 4706 4697 4718 1329 4711 1537 4702 4724 4729 4713 1349 4712 6622 3028 2932 351 6389 2597 808 805 488 PMC4344782__F9 Alzheimer-related protein association network in AD-iPS5 neurons 824 2932 6622 5533 808 351 4709 5532 836 374291 55851 805 348 4712 4713 4729 4697 1349 4708 488 4706 4724 4715 6390 1345 1329 6389 6392 7386 PMC4348071__F1 Exploiting the head and neck cancer oncogenome: Widespread PI3K-mTOR pathway alterations and novel molecular targets 2195 1956 5290 4851 4853 8650 5728 5163 8626 7249 6009 253260 7248 2475 1029 595 6199 PMC4348787__F7 Fungus-induced changes in expression of the wheat jasmonate biosynthesis pathway 4015 1603 6476 PMC4352617__F3 Proposed mechanism for transcription-dependent p73-induced apoptosis 836 581 23151 8772 PMC4352987__F5 Regulatory pathways downstream of BMP, Fgf18, CNP, Ihh or PTHrP signaling control chondrocyte proliferation and hypertrophy 5745 8817 2261 4882 1267 6772 4208 4209 860 595 9759 23387 3549 PMC4355017__F6 Drugging the undruggable Ras: mission possible? 6120 22934 3098 2023 4199 5315 4190 3939 2746 2805 PMC4357331__F1 One-carbon metabolism and methotrexateMTX enters the cell via the reduced folate carrier (RFC) by using an endocytic pathway activated by a folate receptor (FOLR [A, ƴ]) (a) (; ) 5981 635 4548 875 4552 4522 6470 4524 7298 1719 6472 PMC4362638__F4 IPA-inferred Sertoli cell – Sertoli cell junction signalling pathway 2 57530 51678 100506658 8189 998 8898 999 1386 2002 9863 PMC4362780__F3 Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy 1643 11284 7515 54840 3980 7518 672 4361 6741 200558 PMC4364006__F2 The molecular regulation of autophagy 7405 81671 55626 22863 5728 7249 7248 6009 64422 8408 9706 10533 9140 9474 83734 PMC4364530__F1 MITOCHONDRIAL DISEASES PART I: MOUSE MODELS OF OXPHOS DEFICIENCIES CAUSED BY DEFECTS ON RESPIRATORY COMPLEX SUBUNITS OR ASSEMBLY FACTORS 4541 4698 57107 6834 1352 617 57017 4724 9997 1355 4726 10063 6392 7386 4512 PMC4365348__F5 Shared pathway/ GO categories for DEGs from liver and skeletal muscle tissues 7428 7157 6235 6228 6206 6231 5970 6227 1975 2197 5595 1432 1973 1937 PMC4367433__F4 Pathway for estrogen-induced ASC1 ufmylation for ERA transactivation 6668 55325 51569 595 PMC4367691__F1 ROR1 signaling pathway 3084 1950 7474 2065 1956 4919 3716 3717 5728 6774 673 PMC4369322__F1 A model for the integral role of the Rad6 DNA damage tolerance pathway in coordinating the activities of Fanconi anemia (FA) network and homologous recombination repair (HRR) pathway in interstrand DNA crosslink (ICL) repair 55120 672 5111 675 5888 56852 2177 PMC4370254__F1 Schematic depiction of sonic hedgehog (SHH) synthesis, secretion, and signaling 2736 51684 2737 6608 2619 91653 84976 6469 64399 2735 5727 PMC4383754__F1 Cholesterol synthesis and metabolism in the brain 3156 4035 1718 1717 4864 PMC4384293__F2 Paradoxical roles of autophagy induced by the tumor microenvironment during different stages of tumor development 7249 468 83939 664 665 2309 PMC4385444__F1 Disease implications of the Hippo/YAP pathway 6010 5784 60485 4485 9113 26524 4771 9686 7003 8463 7004 7005 154796 PMC4386406__F2 The phosphoproteomics data 940 5163 27040 5335 6464 572 3702 2885 6654 7409 3932 2316 1385 2475 998 5879 8915 1796 4790 6418 PMC4390253__F1 Construction of the Golgi/endosome network (GEN) and of the IR subnetwork (IRGEN) 3875 1158 4282 847 790 1491 7169 10398 7172 3240 7086 2779 2597 1401 204 302 1191 5284 338 1499 471 7316 7531 4012 337 5589 3643 4023 2286 3798 11331 2934 23152 2888 372 5562 7841 7939 83483 32 3920 100188821 PMC4393358__F3 FGF signaling pathways 2885 1399 867 2549 2888 7249 1848 2119 2118 2308 6461 PMC4394890__F2 MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction 4150 51341 1958 7528 5993 4782 2113 6667 3725 596 5728 7422 284349 2101 4149 4609 10664 9978 1051 4089 2353 1050 6774 5970 6908 6925 3976 4878 207 183 PMC4398389__F1 Unraveling the Molecular Signatures of Oxidative Phosphorylation to Cope with the Nutritionally Changing Metabolic Capabilities of Liver and Muscle Tissues in Farmed Fish 4535 4536 4541 4705 4694 4695 4696 56901 4700 4701 4704 126328 55967 51079 4707 4708 4709 4710 4711 4712 4713 4714 4715 4716 54539 4717 4718 4725 4724 374291 4720 4722 4726 4723 4729 4731 91942 6389 6392 6390 6391 7384 7386 29796 1537 7385 7388 7381 27089 54949 644096 4697 1337 1345 1350 1355 6834 4508 4509 127700 91647 PMC4401222__F1 TLR4 signaling pathway and its relation with atherosclerosis 1896 7099 4615 3661 PMC4401249__F5 DIANA miRPath analysis of target genes for miRNAs downregulated in AD blood 2475 6009 7249 5590 9846 5154 7010 3630 5879 613 6850 930 1191 1021 351 3910 8317 5934 5728 356 572 5266 4193 PMC4401777__F7 Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors 23759 2896 1958 4800 6886 2624 6667 4778 3066 2972 PMC4402390__F6 Metabolic network of CcsR-dependent targets and influence on cell regulatory networks 5162 4512 1537 PMC4404183__F2 Natural history of Beta-cell adaptation and failure in type 2 diabetes 3479 3082 3480 5617 5618 8660 3667 3717 5728 5163 121278 7166 604 2308 7248 7249 1255 6009 2305 3172 27022 1977 1499 6934 PMC4410181__F2 Control of regulatory T cell lineage commitment and maintenance 940 5163 8915 10892 50943 1786 6667 4088 PMC4411085__F7 Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis 7415 10533 25978 2521 PMC4412144__F3 IPA Network 79666 6015 4162 1831 1649 9456 65125 55272 54206 9516 1390 6446 1385 8741 23760 1734 7037 149428 23210 PMC4417456__F4 Signaling pathways deregulated in HPV-associated HNSCC 1969 2261 2263 1956 2064 4921 3105 3106 4055 567 5728 8772 329 8626 841 7187 595 1029 1869 5925 4609 7157 PMC4417466__F5 RPPA analysis in HeyA8-MDR treated with ZA 2888 2885 1398 2886 351 581 85451 1499 572 6714 5829 2064 1956 3925 1978 4609 5970 5925 4436 6774 2335 121340 7157 10413 5888 4313 PMC4419202__F4 Upstream analysis focused on transcription factors after Foxa1 knockout in female bladders 4851 5933 8842 5971 6929 8626 3507 3858 2353 6875 4193 PMC4420468__F6 Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells 6455 56904 3656 3976 51176 7477 5155 7043 3569 2329 3092 2580 7037 3685 6925 7514 3839 408 4734 8202 5330 PMC442148__F2 Protein interaction map around some selected baits in the TGFB pathway 9618 2804 79753 7805 821 9611 2752 64750 9580 1937 1499 4092 26994 55914 5493 9802 83595 4152 9631 26508 11124 57154 10401 2114 4090 6233 4089 6767 5501 5499 7052 2335 6497 5670 4087 4088 2202 6667 2316 5518 PMC4423606__F4 Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models 7167 2821 5207 2539 226 5223 PMC4424395__F6 Signaling pathways associated with litter size in boars 4638 5595 5870 5862 1432 131375 2597 3630 5034 2947 7167 3558 54586 4191 3565 3329 25915 7018 4720 10658 29078 PMC4426090__F6 Proteomic Profiling of a Biomimetic Drug Delivery Platform 387 5880 998 5879 7006 100124696 399 3676 3684 3683 7852 57471 7070 7408 83700 58494 4267 PMC4427840__F3 Pathway map of the histamine receptor response in dendritic cell 140805 100188795 1390 1385 3394 PMC4427840__F4 Pathway map of the Prtostaglandin E2 receptor signaling 3265 4512 1390 1385 1234 920 3082 PMC4431773__F1 Anti-HCV drugs targeting viral life cycle 9076 100506658 975 57762 PMC4435677__F2 Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma 4547 7099 10643 10413 9201 9235 4513 1869 3569 10395 7157 7161 5925 1026 259266 1029 57506 7422 3082 3383 619501 PMC4435780__F1 Adipocyte receptors that have been proposed to promote the browning of white fat or maintenance of a brown adipocyte (BA) phenotype 367 655 79054 5346 23411 63976 7350 1386 5465 PMC4438523__F3 “Actin Cytoskeleton Signaling” pathway highlighting differentially expressed genes of birds affected with Wooden Breast myopathy 3929 1950 2335 2149 929 55970 2885 28964 1398 2316 7204 387 1793 5829 6102 10458 10152 7414 2934 PMC4439933__F4 Detailed self-regulation scheme of cancer development in ERG+ well differentiated tumor samples 2247 2885 847 3265 4893 5906 1869 367 8202 23426 1499 652 3091 2078 655 PMC4442140__F3 Results from validation screens for Listeria infection 387 2475 23621 7432 1730 2885 50852 5045 343637 9260 4633 4609 3688 7094 64065 2197 1315 9276 23191 5879 6132 10890 8682 6165 2549 5295 4952 5266 867 11021 1785 1601 4646 121512 998 8660 1213 1211 1759 3984 23229 1072 3985 2017 10788 10787 10096 10109 29127 10006 PMC4442456__F1 Changes in the expression of cell cycle-related genes during MNV-1 infection 2033 699 7040 7045 56890 7808 2932 472 4088 4089 9232 7532 1647 994 1017 999 7465 PMC4443741__F4 CD44 interferes with apoptosis resistance in HSC/LIC 960 3082 1839 4316 11140 2885 3037 3038 3036 572 2066 PMC4446705__F1 The IL-4 and IL-13 receptor signaling pathways 3566 3597 3598 7297 3718 3716 8651 2885 3667 8554 383 6774 6778 PMC4447103__F1 Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy 2475 8717 7124 7186 85451 9021 5443 3952 3953 6774 181 4852 57120 5465 PMC4450051__F4 Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex 7097 8480 54472 3553 8772 114609 3929 929 8178 23118 51135 7189 958 941 942 4615 3665 1513 130749 54106 3661 7187 7098 PMC4450212__F4 Significant signaling pathway networks mined from phosphotyrosine-containing proteins in a glioblastoma tissue 160287 84659 26499 51650 3257 11245 1117 5802 23362 27309 3198 3073 116985 124044 10131 389677 8642 197358 9143 2023 11158 55125 23167 23468 92483 5827 326624 60 3945 64793 345651 548645 148266 23129 PMC4450221__F2 Mechanisms underlying the developmental programming of NAFLD 7099 3553 3569 2194 PMC4451983__F2 Functions of lncRNAs in autoimmune cells, T cells, B cells, macrophages, NK, and dendritic cells 1230 920 6774 102659353 11091 3191 3458 367 PMC4456045__F3 Negative feedback cross talk between PI3KA/Akt and NFKB signaling pathway by a local brief stimulation of TLR9, a potent preconditioning tool for programming the subsequent responses to I/R injuries and stimulation by TLR2, TLR4, or TLR5 ligands 54106 929 10318 4792 7189 7187 10612 29110 3661 1386 PMC4460810__F1 Wnt/Beta-catenin pathway regulates stem cell pluripotency and cell fate decisions during development 324 1499 960 4609 PMC4461014__F1 Dual function of TAK1 7189 10454 23118 257397 PMC4461826__F1 Mammalian cells employ two principal DNA double-strand break (DSB) repair pathways 672 641 472 3981 7518 79728 5888 545 PMC4461888__F2 p38 MAPK signaling in osteoblasts 5741 2245 998 1749 860 PMC4462367__F2 Schematic diagram of the signaling of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway involved in human cancers 1956 5163 253260 5728 8821 7249 7248 2932 572 4193 595 1977 PMC4463189__F1 Targeting cancer with kinase inhibitors 11035 5058 6093 1436 4485 3815 11184 1445 2475 1493 10461 673 595 472 545 PMC4463661__F1 Biochemistry of hydrogen production in Synechocystis PCC 6803 by direct biophotolysis 7054 4519 6476 5091 PMC4464465__F4 Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury 7124 581 8772 8717 7186 PMC4465296__F1 Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer 3845 9118 5091 2118 7074 999 4193 2002 PMC4466627__F1 Ghrelin receptor controls obesity by fat burning 2693 7350 4513 PMC4468904__F6 Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis 51166 3620 1644 8942 438 314 15 8564 11185 6999 PMC4469326__F2 Toll-like receptor signalling pathway coverage 7097 5879 54472 114609 10333 8772 3929 929 23118 7189 958 941 51135 4615 3665 1513 54106 3661 7187 7098 PMC4469326__F3 TNF signalling pathway 7124 843 840 836 8772 83737 355 3569 7054 7185 8717 1906 64127 197259 6401 7186 PMC4470795__F1 Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis 2821 229 7167 2597 5230 2026 2023 5091 3939 3945 PMC4472614__F4 Functional relations of differentially expressed genes with each other and with members of important pathways, as displayed by FunCoup online resource 9590 6693 23016 2012 3070 3728 1605 5467 840 2241 4000 91624 55920 4820 2353 11033 PMC4473797__F4 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses 7097 7099 4118 3654 7189 7098 7187 3661 7124 PMC4477219__F2 Nrf2/ARE pathway and cAMP second messenger system together are the key regulators of cellular antioxidant defence 9817 8452 23411 PMC4478622__F1 Scheme of the engineered metabolic pathway for the production of 1,2-propanediol and 1-propanol in C 50829 79018 5212 PMC4480235__F2 Signaling by myeloid C-type lectin receptors in immunity and homeostasis 5894 3553 64170 114548 10892 108348016 5971 7124 1960 1959 4513 PMC4482759__F3 From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry 84129 10726 9049 8974 79868 4771 64682 5347 5358 4485 23286 160 11113 5584 324 27101 154796 8030 9113 26524 54504 85440 2023 3030 3032 2810 23136 9146 92799 6500 5784 6709 4008 9361 8027 5962 4133 5604 252983 84962 9448 10910 6645 26115 7402 23513 6117 3337 6787 11052 11051 10687 9931 7003 8463 7004 7005 PMC4484611__F6 Cell adhesion molecules (CAMs) pathway 324 4897 8178 100506658 965 914 1000 58494 1493 3684 3384 90952 920 5791 4267 928 4359 4099 940 6402 941 29851 948 23114 214 923 6401 958 10666 3683 5797 6900 5817 1002 933 5788 PMC4484807__F6 Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome 5879 54472 114609 3929 929 23118 51135 7189 958 1513 54106 7097 8772 7099 4615 923 5132 130749 3661 PMC4487054__F1 Signaling of SGK3 and AKT 2303 3397 5728 5163 23678 7852 6667 2314 7249 572 PMC4489880__F4 When pathways collide: collaboration and connivance among signaling proteins in development 79633 4771 4485 9113 26524 PMC4490472__F2 Regulation of CUL5, JAG-NOTCH, TNKS2, and PTEN-PI3K-AKT cell signaling by members of miR-17~92 and miR-106a~363 clusters in cervical cancer 4041 5728 1499 324 407047 8658 182 5163 3952 8065 2475 3717 6502 8454 PMC4490529__F7 Schematic model of DMF-induced neuroprotection in rat NPCs and differentiated neurons 2950 1728 6648 140809 2495 PMC4491686__F3 Intracellular calcium and cell survival: Intracellular calcium activates the intermediate proteins in the signalling pathways in neuroblastoma 4803 627 1950 1956 4613 572 238 846 PMC4491894__F3 Differential expression of a core set of genes whose products comprise a functional interactome is an underlying feature of chronically wounded RPE cells 2628 2731 1763 79623 4094 4254 7298 2273 79695 2633 2175 5600 894 4940 4602 4060 5270 6696 2274 4175 7398 22801 4008 641 1634 63967 23397 1058 7057 8828 7042 6678 64151 2200 7422 114990 10051 4023 2621 7058 7045 3161 7040 221150 347733 5579 10162 4052 25759 3490 2934 9162 3624 100506658 10461 2335 5552 10468 26052 54101 1909 8038 6422 8324 8503 5644 5332 1404 6590 8111 1902 4922 10874 5367 1363 9159 51083 PMC4493455__F2 Schematic overview of ligand-stimulated SR signal transduction 10011 948 2534 4067 PMC4496332__F2 Dendritic spine dysgenesis in Autism Related Disorders 7248 6009 7249 5728 2475 7337 23237 1827 1977 627 PMC4498776__F6 Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs 4781 468 1950 1956 2002 6722 4342 5530 1379 1386 51804 7124 2645 7186 3553 355 1616 929 23118 7189 51295 PMC4502956__F1 TRAIL signaling pathway 841 637 596 4170 839 840 836 842 581 317 331 8772 PMC4505457__F10 Model for DAXX-mediated induction of tumorigenesis 1616 8408 1612 1613 PMC4506514__F1 Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma 2264 10818 2885 6654 2549 5728 5290 4763 472 1029 1019 7157 4193 5925 PMC4506786__F1 Linear ubiquitination signals in adaptive immune responses 7124 8717 7186 7188 1540 23118 90268 81858 PMC4506786__F4 Linear ubiquitination signals in adaptive immune responses 7124 8717 7186 7188 1540 8737 8772 90268 81858 PMC4508517__F4 Uses of CRY2 domains 1408 207 10519 5894 PMC4508759__F1 Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host–pathogen standoff 7097 7098 54106 51284 115004 6772 57506 4615 4599 3661 3665 6041 6035 7018 PMC4508762__F3 Transcripts regulating the Wnt signaling pathway are putatively affected by up-regulated miRNAs expression in the PCOS patients when compared with control 51701 324 4089 4088 9350 3952 6500 6477 8454 9978 2040 9475 23002 387 PMC4509139__F3 Map of the Wnt signaling pathway, which includes at least three Wnt signaling pathways, namely the canonical pathway, the planar cell polarity pathway and the Wnt/Ca2+pathway 51701 9350 1499 324 4089 4088 25805 50964 51147 6500 9475 23002 387 PMC4514086__F3 Cytosolic RNA and DNA-induced type I IFN signaling pathway and its regulators 7706 84282 84166 23586 115004 51428 3428 9960 57506 79671 7187 9140 9474 197358 5094 81844 22954 147945 29110 3661 3665 2932 9111 6737 7186 7189 PMC4514180__F4 Signal transduction pathways drive cancer metastasis 1950 3479 7039 1839 3480 126669 2885 PMC4515859__F3 Biochemical network of arachidonic acid metabolism 8399 5730 4513 5742 10728 1359 2053 124975 242 239 247 257202 4048 PMC4518307__F5 Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst 3101 55276 5209 2821 5211 230 2026 2806 79944 4190 3418 6539 6540 6520 1468 4149 2147 PMC4519426__F5 Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes 100188011 1839 5045 63826 10683 142678 7039 8650 222484 9253 8777 2885 847 64750 1601 3066 3265 4089 4087 1499 4088 5728 6502 100188776 26508 4133 253260 84667 7422 8454 9978 2108 1869 1386 171558 5111 7913 960 6868 8325 28514 4214 2034 8321 6423 PMC4520755__F3 Canonical Wnt signalling pathway and pharmacological inhibitors under investigation in cancer 4040 4041 2011 324 1499 607 4613 595 6927 5468 4316 960 4513 PMC4522390__F1 The Repeat Expansion Diseases: the dark side of DNA repair? 5893 4968 79661 7507 5423 5426 2237 3978 PMC4522610__F1 Main extracellular stimuli and intracellular signaling pathways leading to astrocyte reactivity in ND 6647 1270 3569 3553 9021 6774 4513 7018 2670 PMC4527592__F7 Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation 3091 5236 4277 3099 5214 130013 2023 226 729708 2597 5230 PMC4529006__F1 Genes within the BDNF signaling pathway [adapted with permission from Macmillan Publishers Ltd 627 10818 2885 2549 6853 5170 814 PMC4537170__F1 Mammalian base excision repair and single-strand break repair pathways 4350 79661 5423 11284 5111 7515 5426 3980 2237 3978 PMC4539002__F1 Proteostasis network (PN) 338386 4354 821 51501 4077 9531 10533 9474 PMC4539601__F2 Cluster-guided pathway analysis of the response map 717 999 718 55872 1499 3725 572 596 10682 729 727 6714 5111 6247 545 1956 673 472 4513 637 PMC4543753__F4 Transcriptional gene regulatory network in VBL-treated KB-3 cell 5707 231 5066 4478 5717 8870 4790 967 6385 71 5970 3861 2012 3678 8877 10916 1026 11031 7157 824 5355 3866 3872 PMC4547497__F2 Signaling pathways associated with CLRs on dendritic cells 5132 6850 8915 10892 64170 PMC4547762__F4 Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes 2273 735 55699 10765 57175 7706 5631 11168 5705 3934 4318 57506 10631 10135 5694 1991 4057 1508 4353 PMC4548197__F1 Neuronal apoptosis network 637 572 581 596 4193 842 836 PMC4548949__F3 Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus 3938 9615 7054 2645 1841 2272 2821 56655 5625 1635 1158 2628 7170 26 7139 384 70 5009 151056 4635 4953 5465 7057 9388 2194 84649 31 7058 3371 1737 8525 4023 2318 3725 5337 47 162466 2100 8660 PMC4548949__F4 Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus 1301 5590 60 824 3667 9601 3337 5159 2246 7057 3480 9965 348 4313 1374 154 3725 81490 1634 7097 162466 23761 9388 873 1586 226 1553 9945 3099 2645 635 4881 4830 PMC4557106__F3 Pharmacologic modulators of the Hippo pathway 60485 4485 6010 9113 26524 324 7525 6910 PMC4560668__F1 WNT signaling in adult ovarian folliculogenesis 324 1499 10664 PMC4562270__F4 Proteomic approaches for profiling negative fertility markers in inferior boar spermatozoa 183 1050 554 7040 551 6648 2879 3320 7412 5595 3329 5594 3030 3458 4204 6773 5743 4609 3553 3313 5970 7384 6342 596 60 2597 10376 2947 5862 6774 3569 6389 54205 684 351 5599 836 207 87 2813 49 7124 2932 3630 7157 581 1869 840 5162 6667 133418 2995 84519 PMC4562633__F3 Discovery of Intermediary Genes between Pathways Using Sparse Regression 63901 80223 51762 3717 55181 2829 5599 5055 5743 136 5341 11214 54329 8892 5971 5606 100187907 6348 2107 10890 64083 58489 54545 3383 4880 8676 11021 1977 146850 102723505 2098 339745 4940 114836 6892 50865 197342 5721 5698 5696 5692 8546 10392 693167 100313781 3654 80279 9518 PMC4562884__F1 Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development 4920 4040 4041 57216 324 6010 PMC4564046__F1 Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution 9817 8452 2729 2730 5052 7296 1728 4094 PMC4568025__F2 Interaction network for human CIBLIN transcriptional regulators 9139 2300 579 2303 4824 2637 219409 3280 3399 9242 91133 26013 3397 51450 11281 6663 6939 4613 2120 3199 30812 8543 6943 10660 57798 4610 7019 6662 3212 84662 148979 169792 4862 121536 9575 4609 4299 27125 10474 5326 7705 80306 90390 4335 7392 9441 339324 55090 5469 23036 4772 4776 118738 6239 4780 10725 4773 2354 55588 56252 4775 9603 10025 81857 9862 2353 5252 5993 4899 6007 9095 10745 5201 2101 10943 8521 1389 4481 2553 2103 133522 5971 60468 4778 4791 4520 3423 3110 4790 5325 PMC4569015__F2 Control of cell cycle transcription during G1 and S phases 1017 1869 1870 1871 144455 79733 1876 717 PMC4571319__F1 ERRs are key transcriptional factors that regulate cellular energy metabolism 6513 6514 154091 6517 3945 3939 3099 2597 2023 34 50 1431 4967 6390 29796 1347 1337 PMC4572003__F2 Network integrating gene–metabolite associations and metabolite–metabolite correlations 133688 81537 116519 55304 130013 3990 1577 23042 348 635 875 1558 10101 79143 54898 10599 51555 3992 189 257 127343 5723 35 34 4678 6539 239 57733 6319 26227 196 4363 1373 3712 284111 6591 56172 49855 9057 196743 1071 1312 26001 8972 2639 5625 1559 11234 399671 10019 115584 5832 123876 84795 2646 3818 6999 410 9027 51477 54716 290 3827 26873 27165 2806 2524 117247 1644 5053 54988 374569 28 2328 135293 10257 339896 2766 PMC4572416__F3 Pathways to AT2 cell injury/dysfunction defined by using mutant proSP-C isoforms as prototype substrates 8411 3916 967 468 7186 PMC4580556__F5 The debulking signature 4015 1281 1311 1513 1300 26585 6624 1462 2335 10631 5159 7048 2885 1958 6655 999 1586 6935 5328 6591 648 2626 2735 2934 4086 4088 7130 54829 9547 7078 7045 4313 4060 59 2191 2213 5054 5396 PMC4583600__F2 Cell biology functions and pathways of the genes involved in melanoma susceptibility 595 4193 1019 7013 7014 26277 54386 580 672 221937 7528 3607 171023 55252 8520 8473 65057 25913 7015 PMC4586249__F3 RecQ helicases in base excision repair (BER) and double-strand break repair (DSBR) 7486 79661 4968 4350 7374 142 11284 54840 55775 5423 7515 5111 5426 3978 2237 641 9156 1763 5888 7518 5893 80198 3552 116028 80010 PMC4588066__F1 Regulation of oocyte maturation 2827 4342 4661 7465 983 324 PMC4592906__F2 TNF-induced programmed cell death pathways 7124 1540 197259 8717 8772 PMC4597147__F4 Regulated protein networks in GM-BMMs versus M-BMMs 930 948 2920 972 6517 6542 5330 3579 27040 933 2690 3456 7535 3931 3043 348 7124 307 931 2949 1499 1742 245972 55824 8417 1447 10938 8674 2534 5879 332 4843 6453 847 7019 3157 3055 1445 9844 1796 65985 4067 3315 2353 1794 9588 4597 2879 3925 5371 63924 9479 2885 3422 998 1523 8615 4023 1149 6010 1728 54874 2171 2224 9817 8452 26207 5781 8848 2194 2760 1553 6721 23175 51701 4780 230 2023 55294 867 5214 5836 3945 22934 7316 7538 5931 23054 1994 165 5928 6774 3091 472 7157 7153 1786 55636 10714 9969 7181 10062 3172 2308 5981 6240 3170 7182 5557 7376 4609 468 5111 PMC4600211__F2 Pathway Express analysis of the host response to IBV infection in the trachea of susceptible birds (Line 15I) 3458 6891 821 811 567 1508 1520 920 972 7097 5879 29949 114609 10333 8772 3929 929 4615 23118 7099 51135 7189 958 941 1513 130749 54106 3661 7187 PMC4606174__F2 Crosstalk between signaling pathways that lead to colorectal cancer progression 4040 4041 999 2885 1956 5728 324 1499 572 PMC4606863__F1 Eicosanoid Storm in Infection and Inflammation 4048 4050 4056 4513 4512 5228 6916 8989 7442 PMC4606863__F3 Eicosanoid Storm in Infection and Inflammation 7099 114548 4513 3553 PMC4610626__F2 Multiple activating human natural killer (NK) cell receptors and representative signalling pathways of 2B4, NKG2D, DNAM-1 and NKp46/30 27040 6714 2885 5879 6850 7535 5058 10451 7410 7409 PMC4611218__F3 Effect of oral foreign plasmid pcDNA3 on complement activation classical pathway 6418 5648 718 727 729 5901 735 PMC4613493__F1 Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism 7086 6888 5226 3417 4199 PMC4617137__F1 Anabolic pathway of renal sulfatides 79993 64834 83401 54898 6785 60481 79071 79152 10715 253782 91012 204219 29956 79603 6611 7357 PMC4617749__F4 Kyoto Encyclopaedia of Genes and Genomes (KEGG) annotated the Toll-Like Receptor Signalling Pathway as significantly enriched in the RNA-seq dataset for HC 5879 4615 114609 3553 8772 3929 929 10454 51135 3654 23118 7189 7099 7100 958 941 942 3663 51311 51284 3665 1513 54106 3661 7187 7098 6772 PMC4619615__F7 Structure-Activity Relationship of Synthetic 2-Phenylnaphthalenes with Hydroxyl Groups that Inhibit Proliferation and Induce Apoptosis of MCF-7 Cancer Cells 355 581 595 891 983 1019 1017 PMC4620942__F5 Modeling the calcium-mediated pro-apoptotic action of less toxic natural products 331 468 1649 83939 3643 PMC4621004__F1 RAGE signaling pathways 4018 3146 6714 387 5879 998 6722 1958 PMC4622601__F1 Mechanism that result in aberrant Wnt/Beta-catenin signaling in colon cancer 6422 5728 1499 324 3845 999 PMC4622872__F1 Pathways that play important roles in melanocyte and melanoma development 1956 3815 715 673 5728 2475 3383 7412 6663 4286 7186 7185 7306 1019 1021 PMC4626583__F3 Function of bacterial actin nucleators during infection 445347 9360 150684 6464 PMC4629002__F4 Networks predicted by Ingenuity Pathway Analysis in Cmah-null mice 5465 875 51286 343 1958 2950 57817 4023 10397 9027 8991 8864 6097 7069 30 51129 51 8048 212 65985 23316 8653 3991 9563 1962 3952 79071 2330 80270 84935 10038 9969 5468 6258 6777 6845 7086 440 435 79174 3040 2645 3106 3039 26232 3480 50486 10625 83737 3636 4496 3551 6776 50814 5947 6004 10417 9099 2289 3579 7832 196 348 9049 3312 3298 2779 2328 3320 3326 4907 6010 10808 3485 6647 7157 7296 7037 6446 6786 145264 10963 PMC4629436__F1 Representative HIF-1A regulatory genes and their effects on cancer progression 2056 133 3952 3098 3099 3481 4035 3484 3485 3939 5315 3486 7039 3398 PMC4630370__F8 Proposed mechanism for NFKB signaling inhibition mediated by the antitumor peptide CIGB-552 83737 7189 6885 8945 6500 5608 23474 150684 80854 PMC4631624__F1 Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer 57697 2177 472 80198 22909 2072 84464 580 672 1763 9156 641 675 5888 79728 PMC4631799__F2 ERBB signaling pathway is highly activated in AA PCa specimens 1950 7039 100302114 6772 367 2064 6714 693219 1398 685 3725 85451 1839 4609 2885 2475 2549 2066 572 100126347 4170 3709 126669 PMC4632093__F1 Nodes-and-connections strategy generating an interaction map of signaling molecule network required for the fulvestrant-induced MCF-7 cell apoptosis 1616 23604 468 57118 2908 1612 5074 6093 1613 5590 814 4633 7157 2888 9002 10398 91807 5601 638 2066 4659 5605 801 5609 6714 6774 55824 1445 PMC4633447__F4 Schematic diagram showing the possible consequences of SLC7A3 dysfunction on the mTOR and NO pathways 5728 7249 7248 6009 2475 64798 64223 1977 8408 PMC4636073__F7 T cell receptor signaling pathway showing downstream mediators regulated by DNA methylation, gene/protein expression and/or protein phosphorylation 915 916 917 5800 920 940 1493 5133 919 29851 2534 867 3932 7535 9402 3937 27040 3702 5170 2885 207 6654 5335 4690 7409 8440 1326 3265 4893 2932 3845 5058 387 9020 998 5580 84433 5894 8915 10892 1147 6885 5604 3551 8517 5605 5609 4792 5594 5595 4793 5601 4794 4772 3725 2353 5970 4790 3558 3565 3586 1019 3458 3567 PMC4636767__F5 Schematic presentation of a model highlighting the probable mode of action of AMA on placental development 6347 6348 6352 3627 3569 3603 3559 7124 4282 PMC4637208__F4 Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts 5226 25796 2539 2821 7086 5214 226 2673 2597 2194 23597 5230 1738 1743 47 2023 8803 50 10455 54205 34 10063 5315 5162 2271 4200 3939 10059 5660 4074 950 51449 1508 1509 8878 7942 6352 PMC4637888__F4 Novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway 1537 6469 6608 2735 51684 6491 PMC4638384__F3 Regulation of the Hippo pathway in mammals 154796 4771 5784 4485 60485 9448 6010 6477 6478 9113 26524 23558 23513 983 PMC4638384__F4 Therapeutic targeting of the Hippo pathway 4485 60485 6010 9113 26524 7003 8463 7004 7005 PMC4641522__F4 Paradigm for testing the multiple independent mechanisms that reinforce IDO1-mediated immunosuppression in malignant glioma 9021 169355 3620 405 2308 324 6588 PMC4641948__F2 Thrombin effects in endothelial cells involve S1P signaling 124976 6010 8877 PMC4643957__F9 Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States 652 4040 4041 2821 PMC4644376__F12 Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression 1956 374 7039 60485 9113 26524 PMC4644679__F1 Hippo signaling pathway and main regulators 4771 999 718 9686 6010 8313 374 6657 1499 3398 332 4609 PMC4645172__F5 Glatiramer acetate treatment negatively regulates type I interferon signaling 4049 7099 7097 4615 7098 6772 1386 3661 7124 PMC4645345__F9 Proposed mechanism for SCG2 expression in HSV- and reovirus-infected cells 387 6010 7857 PMC4651655__F1 Mevalonate pathway, NHRs and immunity 38 3157 3156 4598 10654 4597 2224 2222 6713 4047 1718 3930 6095 50814 10682 1717 7421 5241 367 2099 PMC4652152__F8 Comparison of gene networks affected by ozone exposure in males and females 2919 959 2921 6374 1435 3627 958 2353 7100 7097 4050 3606 6351 5743 929 4843 4049 3458 790 6347 PMC4652402__F2 Linear Motifs in T cell receptor signalling pathway hsa04660 3932 920 867 2534 7535 998 6010 27040 3702 2885 3558 3565 3586 10125 3458 8915 29851 PMC4652780__F6 Network overview of the biomarkers in lung cancer and ALL 5426 4322 5603 31 79813 471 3609 2889 4942 811 596 161253 22976 27340 821 780 3938 5471 5328 5690 3486 948 847 2628 11052 974 5828 1462 11040 PMC4654680__F1 Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer 23513 4771 999 10207 8505 26524 474168 374 9686 4853 182 332 51421 6591 6657 6910 PMC4656203__F1 Folate transport and folate mediated 1-carbon metabolism in eukaryotic cells (for gene abbreviations and enzyme commission numbers, see and , respectively) 2356 10797 8836 25902 160428 5981 275 6472 2352 10840 2618 471 10588 10841 4363 6470 PMC4657121__F1 Amino acid metabolic pathways targeted in cancer therapy 6470 7166 26227 435 445 586 27165 PMC4657516__F5 Antioxidants in Translational Medicine 4094 9817 5728 8452 8454 PMC4659591__F10 MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma 1019 1021 983 1017 494327 7157 572 581 4609 664 3480 3481 3479 PMC4661210__F7 JNK1 exerts kinase activity on several transcription factors and BCL2 family proteins through phosphorylation or ubiquitination 596 4170 2353 581 3725 2002 90427 1386 PMC4662454__F5 Targeting cancer by binding iron: Dissecting cellular signaling pathways 4040 999 1499 2932 4088 4087 387 324 4089 1000 6935 PMC4662490__F3 Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma 898 1017 2810 56475 472 10912 545 355 637 4609 581 54205 836 4193 64393 64065 3486 4194 3732 7057 143686 1643 7249 5728 55240 5546 PMC4663793__F3 Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway 595 1017 56475 472 545 637 27113 4609 842 836 94005 64393 149345 317 64065 3732 7249 5728 4193 64326 6477 PMC4665079__F4 Death receptor signaling pathway 7124 355 8717 8772 7186 PMC4669955__F2 Emerging Role of ABL Kinases in Solid Tumors 7852 6714 25 27 1600 7204 595 2475 6010 10006 3516 PMC4670612__F10 Ingenuity Pathway Analysis of the subset of day-one genes that differentiate long-term success or failure, divided into two groups (F and G) following an unsupervised cluster analysis 4146 23034 2005 126393 84897 84515 51200 1029 100506084 2147 63901 7124 57633 85002 2686 254394 29980 5879 5925 154 79707 43847 401285 9143 4609 55907 9938 284129 55435 8747 25829 132 60386 414061 7316 10283 84135 1975 3780 653519 51463 374900 9451 80055 51706 55733 79962 170959 162494 1073 127343 PMC4671004__F1 BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer 1956 1606 2475 253260 5141 596 4170 581 578 1977 PMC4671996__F4 Transcription factors and genes that regulate PDKs regulation 2475 3939 4609 5132 PMC4674750__F3 Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs 3099 5226 5209 2203 5214 2147 2597 8626 5230 2023 3939 5132 PMC4681826__F1 Signaling pathways activated by BCR-ABL 2885 1398 867 1399 9846 4193 572 PMC4681988__F14 Aspirin blocks signaling pathway involved in platelet activation as laid out by our algorithm 5595 5594 4133 8480 5742 9118 5894 23236 3265 2792 9002 2782 2770 2147 2149 PMC4684962__F5 Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer 55638 5873 8773 1207 712 23387 2011 10126 50628 83540 112755 127833 6804 11243 10403 6844 434 23019 11338 51719 85378 5905 4850 10291 9793 80776 4926 6337 23636 9295 79570 10806 476 6507 8844 286183 3183 4928 6426 8775 10844 1479 7307 162 54820 95681 85407 64764 23193 1213 10142 1454 10236 53981 29101 55755 10518 5613 23500 7841 24148 5142 6339 51517 1857 2624 7479 1907 8218 51684 118 2004 718 6938 5893 2060 79718 6548 5106 5516 142680 23649 5518 6422 3398 3660 8289 6599 135 152 8650 5566 4172 9455 6794 8190 79039 2785 1759 6907 55215 54962 7030 8570 1906 6117 83737 93 94 1909 3171 5576 7037 10589 2786 3708 7507 5591 971 6597 23309 253260 4086 55970 5587 2887 1643 659 6829 23764 10000 8395 3709 7043 93624 4089 2771 6382 6372 2548 7528 54840 4726 2475 207 54539 9817 3400 9462 8821 2118 1051 10563 23533 8642 9392 5297 5791 974 2064 7182 8454 5715 5371 8398 6688 3551 23085 818 4707 4728 4780 1951 1952 5100 5467 5335 919 5966 5329 4696 200576 3570 3588 1508 2113 3984 5082 5621 5296 4790 4713 64403 8310 126129 2252 823 3716 55824 9862 23389 6464 10735 8874 9844 163702 3932 926 122809 9969 8784 3693 3908 7402 54472 5583 8853 10274 55742 4804 5154 9402 3560 81857 2822 9459 5228 8822 10025 9441 3913 7791 3485 5306 1958 10945 7016 1113 392 3683 5376 6868 7305 3669 10410 11015 23163 2317 9886 26574 9564 11156 26286 3818 11128 103 1308 3681 7804 4629 7204 9754 637 27 79709 5351 5782 84894 4035 8997 4836 5327 116443 72 84952 51807 9181 55290 322 2872 84790 253314 7100 51306 4642 54106 79784 PMC4686785__F8 PPI human module 7220 5566 260425 5208 9456 2895 5066 9590 83988 54910 4842 320 7141 9419 3706 57554 7142 5997 10755 27165 2036 2893 5592 6674 5579 57113 6274 3709 7225 4900 6010 9311 60312 5336 8525 5581 9228 351 113026 5728 9651 3266 10564 8871 116986 6358 10810 PMC4688235__F1 Recent advances on viral manipulation of NFKB signaling pathway 7097 7099 7098 7096 10333 114609 4615 57506 7189 8772 54106 51311 51284 115004 3428 51428 6352 23118 257397 10454 PMC4693271__F4 Ubiquitination-mediated signaling cascades in canonical and non-canonical NFKB pathways 958 8717 7187 7186 81858 257397 5971 PMC4693901__F2 Protein kinase C (PKC) involvement in cytoplasmic signal transduction pathways in the immune system 613 7099 324 4615 940 114609 5335 5163 7189 29110 8915 10892 3661 3665 3569 3458 PMC4694672__F7 Silk + bLf NPs induced apoptosis in EGFR +ve and EGFR −ve cells.Notes: Internalization of both forms of nanoformulation was facilitated via LRP1 receptors and EGFR in MDA-MB-231 cells and via death receptors in MCF-7 cells 1956 594857 4035 355 581 PMC4697333__F3 Reconstruction of Notch signaling pathway (target instance) 55759 10683 4237 5045 5296 6714 92714 51176 207 5295 864 83737 113878 3932 429 6868 1499 11059 29924 8788 1840 8650 4088 814 322 4193 4086 9253 892 390 5590 4851 1147 351 5664 3955 5663 79094 1272 2033 2099 3714 182 5594 9794 84441 4853 5595 5588 57534 102 22938 54567 2932 55333 3516 6929 7528 6015 23013 23429 2273 7157 9612 6502 6045 3065 4100 8454 51676 3066 54880 8819 3717 5970 6774 3725 2647 9734 4084 23493 3280 25942 55502 10608 4335 PMC4697333__F4 Reconstruction of TGFBsignaling pathway (target instance) 1032 23019 4850 6093 80153 1026 29883 595 993 898 4849 64682 5519 29882 51434 29945 10393 51343 7071 672 8881 996 4609 5934 5515 5829 5925 5933 5594 4790 6500 4204 5747 83737 387 9133 5903 3837 8021 3622 6498 2339 857 5894 8454 7043 2280 55120 5296 9972 2022 9564 4221 6497 6935 3065 3727 57154 79753 1398 409 10755 50855 1855 1499 64750 5604 11059 6678 3688 94 3690 7161 4089 1387 9765 9212 10664 467 7329 64328 9063 163 10131 23339 51176 150094 57559 1601 4092 4087 5575 83657 163126 864 4088 6667 3726 8945 6711 64219 10987 4303 116448 4435 11171 7189 2034 4094 2033 79023 9146 8313 861 83658 2353 51592 2113 3725 7050 22938 6464 8723 6642 6925 5608 5629 6794 1432 8928 5371 114790 4830 2130 7421 4760 3175 2932 1386 7341 8554 2099 5606 6654 5595 6714 1616 8925 5163 26145 10413 4208 367 2885 1959 8648 5063 2290 51586 6879 25 4116 23049 2475 9924 8570 255967 5073 9024 995 3551 PMC4697333__F5 Reconstruction of TNFAsignaling pathway (target instance) 26958 7709 29843 11316 10628 5609 1314 372 5440 5601 904 7295 1535 9276 6416 59343 10398 5434 5432 5441 4528 4163 9462 9055 4638 7430 389493 55312 5371 10155 1387 6601 10128 1796 5515 10293 6597 3838 64332 8567 203 2720 602 9043 70 64320 6605 10914 9908 7050 8237 6598 55512 28512 8439 5519 10808 28511 8726 11186 5977 5971 83737 5970 6655 4794 6850 5966 50964 5579 1654 9099 6500 8454 207 5581 5747 5590 64112 5925 11124 10156 4172 7132 8945 50976 79155 4791 5708 7965 7133 6207 8517 835 4176 8738 51147 4582 843 329 23291 2065 10392 5836 200081 2752 8877 22821 6595 3308 8837 7124 8717 4171 8554 11035 8772 29110 54110 1409 5580 55072 943 841 6599 140823 3551 10454 581 3320 1410 257397 23118 11140 2475 7531 27035 4214 9755 56616 3659 208 5495 4215 124056 5879 637 10856 3921 51071 10010 5178 9516 148022 9641 598 10987 8533 4087 7248 5781 6124 596 7187 7534 10920 6602 6205 7532 5682 2011 5604 51138 5683 6256 9253 3725 5702 7529 7189 353376 26586 249 3306 5607 81566 4751 653361 7533 1432 10514 2091 6142 9670 735 2353 5691 1647 9861 5701 5595 5719 4088 5713 377 3784 4607 1536 26585 1385 22954 3689 5578 9138 8471 1956 3667 9261 6198 PMC4697333__F6 Cross-talks between TGFBsignaling pathway and TNFAsignaling pathway (target instance) 3921 8665 5688 1535 4591 6205 56957 2475 5966 3716 8567 8445 5719 5709 8439 5178 100653365 9618 9253 55504 9821 70 353376 8890 10808 835 81566 4831 8738 7248 25 6093 10010 7189 348995 6643 8723 1432 10392 4175 6655 8892 8812 9134 10072 1410 6955 6642 10755 409 6199 3315 9530 29883 79023 7132 5708 10454 4176 9670 1031 58533 2316 8751 898 2932 7049 2339 3690 9133 7040 6678 55973 2177 836 6464 843 5580 4582 2734 9099 6850 472 8784 9188 1967 11316 51226 1314 9276 9774 675 2287 94 2022 1398 578 26958 7531 596 372 23770 4172 7128 150094 672 4091 3895 57154 4830 8669 5608 9232 5606 7029 1601 7071 1385 26994 64332 10293 55294 28512 2130 5934 11171 9564 10393 6925 29882 83658 11065 677 6714 27141 1536 9462 4607 9043 1870 5308 51529 3665 1871 1874 4092 7534 64750 83657 10914 10920 4435 29945 8697 8881 10413 9055 7529 3306 84231 6233 60436 4609 5987 51176 54778 9146 3646 4089 2074 27044 64320 5441 6595 7533 5437 9314 2065 4760 5467 51147 51138 23095 26586 1387 9839 3842 6497 163126 3622 1616 6794 10664 4303 7004 4087 5971 142 3727 116448 4094 864 84432 2034 6935 5241 8021 2064 4208 1386 3726 377 6597 6598 5435 861 57510 8928 6722 154075 10370 2113 7428 64328 51586 6605 26585 55827 26145 59343 3207 1482 467 7161 7538 815 23077 287 8925 3087 8805 9516 8648 5915 4204 167227 51003 4849 6120 367 8721 7709 29843 26054 80153 11340 3205 4438 57520 4850 23019 3170 6881 54345 23039 65109 11243 22894 4212 6657 4116 661 57617 91662 9138 9887 65082 23049 51560 5578 64601 23293 10105 5699 5073 9924 9024 995 51028 255967 84735 8570 5698 PMC4698384__F3 Downstream gene targets of predicted cytokine and transcriptional regulators 1265 5054 710 4082 7056 920 2014 4613 7358 3133 972 4360 4256 1634 2326 2520 6646 3398 7373 837 7133 3934 4208 11096 1050 3553 10631 6774 1536 3108 1675 6910 3123 10894 54 6688 8863 7465 4851 3458 3586 7124 6778 1520 1628 8418 3489 4792 2212 2634 3486 3667 3117 PMC4698510__F1 Molecular mechanisms of alcohol-related liver pathogenesis and therapeutic targets 1571 23411 3661 7038 3569 51094 PMC4698632__F8 Telomerase reverse transcriptase acts in a feedback loop with NFKB pathway to regulate macrophage polarization in alcoholic liver disease 3654 51135 7189 4615 3550 7015 4843 7124 3553 920 7099 PMC4701060__F1 Signal transduction pathway like mitogen-activated protein kinase/extracellular signal-regulated kinases signaling pathway 2534 2885 6714 324 1499 6774 2353 3725 1019 1017 4193 8772 572 581 7124 6608 PMC4712384__F2 HCV replication cycle 975 1956 3949 1969 9076 100506658 29881 PMC4715579__F6 Top biological network generated by Ingenuity Pathway Analysis for differentially expressed proteins of (A) ALDH+/CD44+CD24−, (B) ALDH+/CD49f-EpCAM+ and (C) CD44+CD24−/CD49f-EpCAM+ 203068 4926 23451 6780 8531 6175 2934 4771 10135 9361 6628 3329 10575 22984 9373 311 1452 10856 25814 826 9589 5629 10987 2739 23435 2521 PMC4716033__F2 p21-activated kinase 4 signaling pathways in gastric cancer 3082 7040 10298 4088 4087 4313 1499 595 1956 1950 PMC4718075__F2 Adipocytokines and Hepatic Fibrosis 3717 26060 9021 6774 PMC4723085__F4 Uncovering New Pathogen–Host Protein–Protein Interactions by Pairwise Structure Similarity 5600 602 4792 23390 5052 7321 136319 387 7334 389 10935 5536 7323 5716 1432 1029 11124 PMC4723140__F1 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone 5315 5586 4190 3939 25874 PMC4723140__F3 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone 3157 1717 3156 4598 6309 50814 10654 3422 4597 4047 2224 6713 2222 PMC4724579__F4 Toll-like receptor 4’s signalling pathways influencing hepatocarcinogenesis 7099 79923 3146 PMC4726671__F1 Hepatitis C virus life cycle 6010 1956 975 3949 9076 100506658 29881 348 PMC4726722__F2 Nrf2 in the metabolism of rapidly proliferating cells 3417 2539 5226 7086 6888 5471 10797 4199 PMC4727203__F1 Regulation of actin cytoskeleton pathway 6237 22800 22808 2147 2261 5156 2149 4342 6654 6655 1950 2259 27006 673 1398 55970 1445 2247 8823 2249 2256 8817 2257 26281 26291 998 10458 55740 7454 324 5880 50649 10297 5881 8874 10152 4478 10163 9475 7414 4638 1073 85464 54961 2934 PMC4727405__F8 Alternative NOTCH pathway representations 8650 9253 171558 54567 9612 23385 5578 26524 4869 5074 PMC4732299__F5 Alterations in the levels of metabolites and mRNA transcripts that are crucial to energy metabolism in NAF-1(−) MCF-7 cells 4199 47 32 2194 92345 2805 10873 6319 5106 4191 50 5236 10455 2695 37 1384 2752 7086 669 100653365 6888 3939 PMC4732610__F6 Transcriptional Analysis of T Cells Resident in Human Skin 5602 1432 7018 4780 4784 3726 1535 4790 2353 7498 6667 1543 4128 2936 847 3162 2953 25828 2876 4257 7296 2878 6647 10587 6648 2729 54578 6649 4501 50507 PMC4736120__F1 Approaches for xylose-based fatty alcohol production and improvement 355 11113 7498 4118 PMC4736761__F4 Changes in genes associated with epithelial-to-mesenchymal transition after radiation 654 407035 5329 1464 9788 1000 1437 718 4072 3976 8412 1601 3714 9518 8614 3265 6648 2194 7077 3399 3037 5328 79002 3934 3418 4314 7498 7189 1462 1012 4311 9536 51341 7078 4893 3569 1316 253260 100188776 84951 7039 2191 4318 648 6418 57761 154 161882 PMC4739739__F3 Connectivity of differentially expressed genes in the important signaling pathway following mixed PCBs exposure in human PBMC in vitro depicting the connectivity between genes expressed (with ≥1.5 fold change, t-test, p <0.05) 5937 1356 4802 5318 127933 84875 5931 79720 8726 6138 2744 23077 137492 55048 23512 100885774 9015 10553 4661 3728 51160 2618 4000 7764 30000 54556 2987 116986 6651 613 5971 5601 5970 3455 5605 26136 4791 5591 22880 8683 2885 28951 3043 558 2778 2014 488 890 7083 6794 2551 9589 1601 2782 1725 5256 10971 6000 8773 249 26278 9817 6810 10857 1583 4209 10072 PMC4740183__F3 Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease 29958 55349 501 1373 635 23743 5009 435 383 PMC4740301__F3 Monocyte genes associated with the ML ratio are enriched for genes in the interferon signalling pathway 3458 3716 3717 7297 8554 6722 581 10379 PMC4741699__F1 Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors 3845 4193 960 5159 2475 2931 5728 5062 2002 1956 126669 5058 4087 4086 4090 4093 7297 PMC4747727__F3 Proteomics analysis of exosomes from EBV-driven LCLs compared with exosomes from CD40L-stimulated B cells shows “immune system process” as the most represented pathway, and an enrichment in “integrin-mediated signaling” and “cell adhesion” terms 5786 2319 1832 3122 6693 10581 962 2534 3860 3055 4082 2268 388325 3535 6714 2208 3683 3932 5788 5724 56172 2147 57153 928 914 4939 3105 1536 821 23043 3857 51599 151888 471 6185 23654 34 PMC4750502__F5 Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism 2222 6713 4047 1595 7108 10826 50814 51478 10682 6309 1717 1718 8648 9575 5629 4862 1407 2645 60481 1582 PMC4750533__F1 The Akt pathway and downstream effectors 613 930 3716 6850 3611 5728 5163 27250 7249 9776 331 4193 5208 6476 572 581 4661 51083 64798 2549 9846 3667 PMC4751379__F8 Ingenuity pathway analysis of GH signaling after hepatectomy 3481 3479 3667 8651 6774 8835 5163 9021 122809 6772 30837 6722 2002 1050 2 3717 PMC4751407__F1 Disc in Flames: Roles of TNFA and IL-1B in Intervertebral Disc Degeneration 1636 7186 8717 7187 7185 8772 PMC4754024__F1 Transcriptional regulation of IL-12p40 (IL12b) in antigen-presenting cells 207 4615 3394 3661 3663 2114 54106 7097 7099 PMC4754414__F1 Pathways for molecular targeting in prostate cancer radiotherapy 367 1586 3091 2475 472 545 4361 5888 9656 5728 675 5892 7517 7518 PMC4755014__F5 KEGG pathway map (cin04310) of the WNT Signaling Pathway with DE genes indicated 51701 9350 4040 4041 1499 4089 4088 64321 324 50964 25805 6500 8454 9978 6477 23002 387 9475 27130 85451 PMC4755889__F1 Regulation of transcription by YAP/TAZ transcriptional co-factors and the regulation of YAP/TAZ activity in mammalian cells 1956 4771 5163 6469 387 4485 60485 154796 9113 26524 324 1499 332 374 4175 860 4087 4088 6910 5077 25 PMC4758681__F6 The mechanism of Wnt-mediated suppression of osteoclast differentiation 4041 4040 324 1499 4772 PMC4760220__F7 AAV backbone alone has no effect on interferon activation 3458 7297 3716 8554 10379 581 3437 3434 5696 3659 6890 4047 PMC4761106__F2 Hereditary Melanoma: Update on Syndromes and Management - Emerging melanoma cancer complexes and genetic counseling 7018 8314 7015 65057 25913 4286 PMC4761208__F5 Pathway network of the 22 TSGs based on GeneMANIA 100188776 5978 324 8772 5728 10769 581 6789 PMC4765060__F5 Canonical pathway analysis 3265 3845 355 22808 7132 6237 5596 8784 1147 846 6955 7216 54205 5970 27429 56616 2021 790 PMC4765374__F1 Molecular mechanisms of ethanol-associated OESCC 619501 1571 929 217 7099 6469 PMC4768675__F7 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity 114548 10910 7205 8767 PMC4770165__F1 Aryl hydrocarbon receptor signaling pathway is depicted with 3,3′-diindolylmethane as a model agonist 405 196 1543 1544 1545 57491 PMC4770749__F9 BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling 1017 890 581 8772 PMC4770763__F3 Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies 217 4513 150763 4023 493869 5406 55750 9536 5730 5226 874 8527 9162 2539 5315 2821 2026 2027 2203 574473 5224 574461 226 669 7086 PMC4772274__F2 Ingenuity pathway analysis of miR-221 and miR-483 target genes 2332 22849 2353 7832 2554 6310 2911 2885 107 3815 8844 4185 5534 3084 1384 161742 22941 5048 51247 7078 2099 58524 2259 1977 785 6772 11101 4609 6722 2113 28996 25946 5602 5090 4775 4857 PMC4773219__F6 Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy 1497 1472 25973 4595 717 7054 6712 55700 5898 26136 60678 81532 7316 25974 4548 4234 25870 65084 7549 114788 149076 PMC4776098__F1 Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina 5156 4282 7422 10451 920 7253 2324 1232 1000 1956 7852 7301 6622 5979 9590 5062 3921 10540 7052 7204 5330 4627 3326 2885 6004 5480 6624 226 5605 1600 5880 1147 6714 7431 1654 5594 3717 5578 4846 8879 5580 5063 5335 5058 2194 673 7001 5894 6197 8407 5587 5730 4628 5604 6772 3091 5590 7157 3329 25 4092 10013 2475 2113 5290 3927 5080 860 4602 5013 207 10657 6097 4869 983 4609 6774 2309 4172 7428 1410 1072 4171 4306 3397 3399 868 2308 3181 6935 2146 8320 9112 1499 5764 6387 3791 2902 5803 5052 6773 83737 PMC4776098__F2 Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina 4323 6352 6387 2335 2019 4282 5803 1232 2534 3685 1956 558 1000 7852 1233 1147 1445 5052 6464 6004 5058 3717 331 6093 3921 3551 5584 6624 5580 1654 2495 5894 596 7431 5595 3667 2194 3309 4846 5594 3064 226 8877 6777 6774 2034 3091 7428 4609 7157 25 4869 10013 2475 1499 595 1027 3181 10413 2309 PMC4777532__F3 Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance 51060 5649 2534 25864 2571 653689 383 4942 224 2752 2744 27092 384 2572 790 440 88 8464 443 290 6881 10797 56954 275 471 4843 4842 57571 55753 4763 6342 7298 162417 1719 4548 1738 5539 5469 2628 25902 6907 6472 3170 51083 100187761 2731 875 92345 3630 51268 10993 189 1757 1610 9517 6616 210 27232 6844 219970 92292 5864 81888 10249 348158 116285 PMC4778564__F4 Hepatitis C Virus and Autophagy 9474 9140 57506 PMC4779427__F6 DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States 348 347 4688 653361 6416 7043 4973 54897 84665 659 112399 657 10060 26353 3091 2934 3670 1026 3488 1499 1003 6934 PMC4779661__F3 Relationship between cellular fatty acid (FA) metabolic pathways and observed associations of FAs and enzyme acitivity estimates (EAEs) with colorectal adenomas 6319 79071 355 PMC4779832__F4 Cross talk between ROS and Keap1-Nrf2-ARE signaling pathway 8452 4738 2937 57716 2534 PMC4780413__F6 Reduced PARP1 as a Serum Biomarker for Graft Rejection in Kidney Transplantation 6420 27040 5803 8772 3916 1536 50511 3690 5082 367 4762 4046 5705 1356 3551 4170 5909 10243 5594 4145 3925 142 5928 9229 1028 25 134957 6729 1434 4830 23090 7257 4752 8936 898 4067 5595 355 3558 3458 7124 3569 3553 3002 3565 4306 472 2932 356 4843 3162 467 5660 3383 43 3082 183 7040 5664 4092 2033 5743 1843 7033 7157 5170 3479 1649 596 6403 1499 326 PMC4783934__F4 Six miRNAs and their target genes that are involved in milk fat metabolism in bovine mammary gland 5742 5740 6850 246 10630 1906 3248 4023 972 53632 79071 5743 3032 9444 9370 7352 PMC4786553__F5 Top networks activated in the CPu during CIE and acute withdrawal 1356 6507 4209 57451 5345 835 841 627 2913 462 6622 781 5595 567 3064 54205 4282 355 3265 2878 10636 4609 3925 7157 2017 391 9423 5080 747 2668 23129 3956 367 9455 3791 2549 5295 207 57787 2912 5501 6506 92140 5291 PMC4789572__F7 Circadian-disruption-induced gene expression changes in rodent mammary tissues 1017 472 1039 545 355 637 4609 613 836 2353 64065 4193 5728 7249 PMC4790538__F3 Gene–gene networks generated by pathway analysis.Notes: The networks were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA®, QIAGEN Redwood City, www.qiagen.com/ingenuity) 573 6241 81624 1058 596 4605 332 5241 2064 9833 891 4320 10403 2886 84440 4350 23164 57630 7280 10010 26037 29127 11098 9212 84823 9055 23595 5000 2043 9493 51061 4998 5529 79801 4173 56942 81620 8318 8317 2116 85451 6714 4288 2099 80031 57758 PMC4791269__F5 Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network 3551 1431 10000 2309 5111 2475 4609 3265 5863 5898 4193 890 1869 387 1021 1019 997 55294 PMC4792590__F4 Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner 4087 324 4089 387569 572 836 842 4436 581 PMC4794670__F4 Network of type I interferon response- and UPR-related genes 11016 9586 3437 1386 3434 1052 3725 1050 3433 467 2355 1958 440 2354 1051 1053 2353 55509 1054 3669 1649 9636 9111 1628 10538 3131 57761 PMC4795462__F1 New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease 3099 355 29072 8314 55193 47 PMC4796280__F2 Store-dependent and -independent Ca2+ entry pathways in smooth muscle 84876 2475 1977 93129 4056 4827 6786 PMC4803814__F1 Ras MAP kinase pathway 6464 399694 53358 25759 6655 2885 6654 2889 9693 10125 10235 25780 115727 5923 4893 64926 3845 8437 9462 5921 22821 5922 3265 369 673 5894 5900 5294 5293 5290 57139 5863 8844 283455 5604 5603 5594 6196 6197 6195 3725 2353 2113 2114 2002 80824 23463 9986 PMC4804493__F3 Death receptor signaling in SIVA 355 8717 8772 7186 7188 637 PMC4807882__F3 A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer 3577 1950 1493 2885 6714 2475 367 7421 PMC4810129__F2 Effects of virus mediated targeting of PDZ proteins often converge on the PI3K/AKT signal transduction pathway 4018 9368 23513 5728 1739 64236 PMC4811486__F5 NF-Y activates genes of metabolic pathways altered in cancer cells 26227 29968 2673 6470 790 25902 5471 10797 441024 2744 4524 1719 6570 81034 2618 471 2653 5723 1738 2731 275 6472 6510 6520 2638 5198 2746 23530 2805 2806 2875 4199 4200 PMC4811921__F3 Latency-associated nuclear antigen-mediated deregulation of cell cycle 545 472 4193 994 995 993 3397 983 1019 1017 23476 1869 6046 PMC4815185__F7 Visualization of all differentially expressed proteins mapped to the TCA cycle pathway in the development of RAW 264.7 cells into osteoclasts in low serum culture system 5163 5164 5160 5165 5161 5166 5162 8050 100187761 1431 50 4191 4190 3419 3420 3421 3418 6389 6390 4967 6392 8803 PMC4816652__F8 Long-term ERK Inhibition in KRAS-mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression 23005 64781 613 5599 5063 4133 5583 92 4090 4086 3611 50488 PMC4817727__F4 Role of RGS proteins in selected GPCR signaling in bone 846 5745 5997 4772 64407 6002 6001 8490 PMC4818578__F1 NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? 3479 3480 5300 4193 2309 3162 PMC4821826__F4 BCR signaling pathway is the top-ranked network with increasing association with HuR in response to NS3/4A overexpression 930 2885 5728 6850 4067 1445 998 5163 54518 695 29760 25 2185 572 2475 84433 2308 6929 4208 3725 2002 1958 861 613 864 3059 974 973 3932 1879 23090 2534 PMC4822134__F1 Main signaling pathways of PRRs 7097 10333 7100 7099 7096 114609 4615 51284 51311 54106 51135 3656 3654 7098 7189 64127 7187 23118 257397 10454 7186 7188 57506 29110 115004 3661 PMC4822134__F2 Ubiquitin regulation of TLR signaling 7096 7099 7097 4615 7187 51135 7098 57162 3654 7189 23118 10454 257397 29110 7186 3663 5970 3661 PMC4823938__F1 Schematic overview of necroptotic pathway 7098 7099 8717 8772 1540 6774 197259 3659 10379 3661 3665 PMC4823983__F5 Interaction between the genes differentially expressed in response to HDM 374 7293 50943 3559 7292 59067 3605 3596 3606 29851 1233 3586 64806 6356 6369 8288 6036 90865 6367 6347 1232 6351 6361 1237 5553 154 PMC4824563__F3 Network analysis 8651 28951 330 7133 3659 4071 3162 3397 602 1052 326 9960 388 2633 1942 7012 6891 27 29966 2618 6651 2181 7157 2936 2022 8407 7204 10150 92140 10769 1854 PMC4824625__F3 A-to-I editing of coding and non-coding RNAs by ADARs 283131 103 284131 57506 3661 6839 PMC4825606__F1 Diagram of the roles and its signaling pathway of Cyclin B3 in oocyte meiosis 9184 85417 891 324 PMC4826209__F6 WWOX modulates the ATR-mediated DNA damage checkpoint response 6741 545 472 83737 51741 PMC4828918__F1 Figure demonstrates the wide array of interactions present in the Wnt signaling cascade 4040 4041 1499 2475 1956 6009 2932 8312 324 5178 5326 8313 3280 6469 6608 PMC4829974__F3 Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes 8289 3090 3205 1029 595 6195 896 5925 983 1019 891 1017 898 4609 1026 995 545 993 994 7157 472 1111 11200 1387 1820 2033 2152 2153 2885 6654 7535 3932 5335 3937 5777 3702 5781 84433 8915 10892 3708 3710 5880 998 5588 80122 3551 5599 1386 27040 920 5788 5133 1493 940 29851 PMC4830430__F4 Functional interplay between PPM1G and the transcription elongation machinery 472 1025 5496 51574 56257 PMC4833639__F1 Many oncogenic mutations drive nutrient transporter gene expression 948 382 275 8408 5266 5058 5879 PMC4835209__F8 Conceptual schematic of the miRNA signal pathway regulated by TGFB2-OT1 in autophagy and inflammation 2280 2475 26471 7072 103611157 7042 100616470 100616250 23367 10715 339983 9776 64422 10533 8878 834 5970 3553 3569 PMC4836208__F1 Key components of the mammalian HH signalling pathway 6608 51684 8650 83737 2932 2736 2737 8452 8405 64399 1869 3280 5156 3486 3489 2305 596 79923 648 6657 4208 PMC4837572__F3 Synaptic transmission: lipid-protein interactions 23413 4082 857 6714 2932 998 PMC4837658__F1 Mouse T cell development 4602 861 2672 2625 6932 51176 3280 64919 2113 2114 3399 4066 2078 53335 4005 3815 3575 2322 PMC4841025__F5 Insulin signaling pathway 1398 9322 391 885 8789 3991 5566 355 867 10891 9021 128385370 5834 7249 11122 2645 5105 5792 3349 50964 286204 PMC4841705__F3 Regulation of Macrophage NO Production by H 3162 384 4843 6542 PMC4841706__F5 Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases 595 896 1019 4899 891 983 PMC4846903__F5 ErbB4 signal pathway 1950 3084 2066 1956 2065 6464 6868 11059 83737 141 6654 4734 11319 23118 51741 5266 5241 2670 6285 1447 PMC4851838__F1 Recurrent genetic alterations and targeted therapies under investigation in iCCA 6098 2263 1950 1956 3417 3418 2475 4216 5774 1021 7157 595 8289 8314 PMC4853752__F1 MicroRNA network that is involved in regulating myogenesis 2475 7528 4087 4088 4086 4089 23429 595 7913 5081 2146 9759 4617 6722 6667 2260 PMC4853852__F5 Genes under multiple regulatory controls in the PTEN pathway 10000 572 596 659 658 836 867 1026 154043 356 5728 4099 80243 2260 2263 2261 2264 53834 2931 3482 8517 3643 3673 3675 3676 260425 23139 79917 4915 5293 5295 5590 5747 5894 6237 8867 7046 7048 7049 8792 PMC4854959__F1 Androgen signal pathways 6462 6714 367 4088 6736 PMC4855686__F2 CAMs can activate neurite outgrowth through different mechanisms 3897 5879 998 1499 5099 324 6872 1951 1952 PMC4856261__F4 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes 3458 7297 3716 5771 8651 6772 6773 596 581 5696 4938 10581 8519 3659 6890 10410 PMC4859220__F4 Scientific rationales of potential therapeutic combinations with PD pathway blockade 958 6387 7852 1233 6367 1493 201633 3902 7124 324 PMC4859290__F7 Analysis of signaling pathways specific to base:apex comparison 2475 26986 4553 1998 1999 6194 2000 6228 6188 6217 6218 6232 6230 6227 6231 6390 4694 6392 1349 27089 126328 4720 4725 PMC4859809__F2 MicroRNA biogenesis pathways in cancer 29102 3552 54487 466 7514 468 1386 467 23405 PMC4859980__F1 HSV modulates apoptosis signaling 7124 8772 27040 637 841 842 836 840 8717 PMC4862604__F3 Repair Pathway Choices and Consequences at the Double-Strand Break 79728 672 675 5888 5426 118027463 9400 641 84893 5893 51750 57697 PMC4862604__F4 Repair Pathway Choices and Consequences at the Double-Strand Break 196 672 79728 675 5426 5888 PMC4865099__F6 Cluster analysis indicates a potential pathway for MWCNT-induced fibrosis based on two distinct phases 6347 6348 6358 2919 7124 4615 1234 383 718 2207 6361 2213 4321 6696 5321 3479 5739 PMC4866030__F1 NFKB signaling pathway with genes associated with objective PNMS 1950 4803 7039 958 10010 114609 4615 57162 5336 23118 257397 84433 5971 5970 2932 PMC4867327__F9 Schematic diagram illustrating lipid droplet formation, VLDL secretion, and pathways involving hepatic inflammation 10400 4547 7038 348 6611 123 5091 338 471 114548 4513 834 3553 PMC4867367__F4 GR cross talk with the TLR signaling pathway 7187 4118 4615 10010 51135 3656 3654 7189 29110 3661 23426 3066 PMC4868719__F7 Notch and Wnt/Beta-catenin signaling pathway play important roles in activating liver cancer stem cells 89780 324 3280 595 23462 PMC4875603__F6 Expression of genes that function in leukocyte activation in uninfected fetuses 30835 339390 671 1363 7038 26762 6696 3624 4318 6288 4359 5950 4878 5375 5354 PMC4877093__F2 IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling 5328 5327 5340 7422 7448 11197 5329 4691 4041 331 4087 4088 3611 1398 10454 847 6667 1793 2932 51701 7409 387 1499 2885 998 4193 5879 4316 3984 3265 1356 5058 1977 2475 PMC4880142__F6 Exposure of MCF-7 cells to 10 nM E2 (A) and 1 μM G-1 (B) induced phosphorylation of proteins involved in cellular processes associated with cell cycle although the specific phosphorylation profiles varied 1983 10298 7163 64426 57447 5130 5037 23513 238 9531 3190 7112 4904 4139 4609 9101 22872 90780 6732 3925 7764 7374 55837 4082 1676 3838 4869 11054 9908 9166 4836 84612 790 7706 100506658 84335 5894 5605 26003 PMC4880707__F1 Suggested positive feedback loop in SOD3 signal transduction 2534 6714 4067 3055 673 6649 7422 PMC4881570__F3 MiRNAs in cardiomyocyte apoptosis pathway 7124 3716 5728 5581 90550 6774 387 22926 2932 596 85451 6093 842 2475 6722 595 4609 664 836 3091 317 PMC4884045__F1 Mammalian Hippo signaling 4771 5163 387 4485 60485 9113 26524 999 6910 PMC4887024__F5 Feed Efficiency within a Pedigree Male Broiler Line: I. Highlight on Mitochondria 3643 3416 2167 6263 5908 1491 253260 58 213 5053 11155 5213 1158 9448 6722 2876 5708 27068 4780 5689 375 5707 5479 6156 6136 1982 6647 PMC4888492__F1 Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle 867 2534 5163 5164 8471 3667 2885 5728 10000 207 2308 7249 7248 572 3484 6194 PMC4888492__F2 Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle 3667 5163 2885 5728 10000 207 7039 2475 3484 PMC4891409__F1 MiRs and their targets in signaling pathway of LSCC 864 1499 324 595 331 842 5728 23411 10769 5163 5164 3480 2305 6774 3716 6772 10379 3082 2113 4089 7046 4087 4088 3065 6502 51809 4149 PMC4892113__F4 Role of Spermidine-TCPTP in the complex dynamics of pro- and anti-autophagic factors 7808 1956 472 2033 7249 8408 PMC4896923__F1 Involvement of Notch in the regulation of myelination and axonal growth 4803 3516 1848 1950 7975 1616 102 4099 8650 4853 4851 2152 PMC4900422__F1 Constitutive CBM signaling in B- and T-cell malignancies 29851 613 940 973 974 10892 51474 8915 PMC4900611__F7 HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis 4803 1616 8717 8772 7186 8738 8837 572 835 843 596 578 637 56616 4170 638 581 27429 666 10075 331 54205 837 2620 6709 351 1676 2021 142 PMC4905055__F2 Tumor metabolism provides precursors for biomacromolecule synthesis 2539 2597 8877 5224 3939 1636 5160 6648 47 3418 6389 1962 PMC4905314__F1 ER stress induced by oncogenic BRAF and modulation of basal autophagy in melanoma 1977 7186 83939 468 8678 2475 PMC4905454__F3 Cancer stem cells and signaling pathways in radioresistance 4851 4853 960 1499 581 7039 79923 2475 PMC4906788__F2 TGFB signaling pathway 25805 4089 3458 7124 8454 7057 6500 4052 1874 387 10468 4838 PMC4907392__F4 Paths used to facilitate literature validation 5618 3717 5594 5595 6667 2932 3725 2353 3091 PMC4908728__F8 Schematic showing the effects of RBE on LPS-activated microglia 7099 3553 3586 4615 PMC4917669__F1 MyD88-dependent pathway 7099 3929 929 51135 3656 3654 7189 3663 23118 PMC4917669__F2 The MyD88-independent pathway 7099 3929 929 4118 7187 29110 7189 3654 3661 3665 PMC4920181__F5 An illustration showing roles or functions of analyzed retinal disease-related genes 6121 6295 3000 343035 6101 65217 94137 124590 4117 7399 57096 4867 57545 169522 7275 7098 145226 23418 4693 8322 5015 1406 10002 PMC4925815__F1 Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation 3929 7099 7096 10333 7097 929 3606 4513 3661 3394 PMC4925820__F6 Genes involved in circadian rhythm pathway constructed in the IPA program colored according their correlation with circulating levels of tumor necrosis factor alpha (TNFA) 468 3064 3725 54962 23281 7068 2034 3952 5468 6095 9575 3479 6097 4775 56729 8864 31 467 1649 9788 3930 161497 7008 10538 9967 4887 10131 5617 8648 6256 694 5465 1054 9946 7067 2194 1053 PMC4926186__F2 Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses 3716 7297 83939 1999 6772 6773 3454 PMC4929427__F2 Cross-talk of mammalian Hippo signalling with the MAPK, PI3K and intrinsic and extrinsic apoptotic pathways 545 472 3845 369 5894 581 4193 9131 154796 1499 23558 11228 860 5371 983 596 4092 1958 PMC4929790__F2a Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy 7124 4280 5054 3934 4015 5645 285 7057 1439 3579 54209 301 3689 2152 7412 2634 4842 1520 23237 397 9595 4259 2167 4792 4353 3921 10628 3659 3164 2353 9612 1052 3096 3665 PMC4935219__F1 Cellular and molecular targets of MTX, 5FU and irinotecan in the small intestine of the AT 1045 2626 6476 3082 PMC4935811__F3 Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards 1524 383 3394 PMC4936004__F4 LumA-R2 samples overexpress genes in the T cell receptor signaling pathway 1493 962 3932 867 2534 952 27040 3702 2885 8915 29851 940 PMC4936987__F2 Pathway diagram of the glycolysis pathway 4351 3098 3099 2821 5213 229 230 2023 5313 4190 5091 4191 3939 25874 1737 1738 PMC4936987__F4 Pathway diagram of the genes in the tricarboxylic acid cycle 48 1737 50 2271 3418 3421 4967 1743 1738 PMC4937204__F1 cGMP-PKG signalling in the cardiomyocyte 7225 5225 5997 5999 2626 4087 4088 PMC4937511__F9 Candidate SCI biomarker input for Systems Biology and pathway network analysis 301 2194 5236 302 1938 4830 2806 8682 7167 3925 PMC4940079__F7 Differentially expressed gene distribution in rno03320 pathway 335 5360 324 4023 4312 7350 3611 7316 364 PMC4940190__F1 Adipose tissue dysfunction and its effects on tumor metabolism 3939 3099 2597 406992 2475 7494 PMC4941269__F4 Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer 387 1398 100653365 572 3397 6615 PMC4942776__F6 Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification 10055 6613 267 1080 PMC4946323__F7 Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy 4193 1017 1021 1019 595 545 581 PMC4946912__F7 Network of transcriptional regulation and ligand receptor signaling 3239 92703 1994 79754 51230 6774 1385 580 847 1647 1869 6004 627 10614 29984 2935 29889 2026 929 56033 8208 29760 124961 1958 3659 7538 10962 4256 4440 2589 140545 55161 2099 1959 22955 79094 23671 64207 2919 51573 10618 PMC4947211__F1 Schematic presentation of gene network implicated in TLR signaling pathway 7096 4615 7097 10454 51135 100187907 23118 7189 7099 3654 3665 54106 7098 7187 3661 29110 PMC4948278__F2 Cancer stem cells supporting activities of CD44v6 960 920 4179 4323 4313 4318 387 3082 55872 10487 10486 PMC4948278__F4 CXCR4, a marker of migrating cancer stem cells 960 7103 7852 6714 572 1398 PMC4948992__F3a Regulation of biomechanical signals by NFKB transcription factors in chondrocytes 3553 4843 4513 PMC4951290__F1 Nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells 4023 2539 5236 26227 55304 5223 2023 2194 3939 4190 4199 3156 10873 1718 7108 6307 5106 3030 5096 4191 2875 3418 PMC4951400__F4 Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters 2249 2250 2248 2253 2056 1392 7473 885 10718 3084 627 2668 1815 1813 1816 107 108 196883 651 6608 4041 3717 2885 6714 2475 PMC4955670__F4 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer 3484 5590 8837 7033 5879 6237 4790 7103 5595 9181 2719 2353 598 10018 3725 581 596 174 4609 999 3934 1030 7157 5781 6925 595 7048 840 4193 672 6790 1870 896 PMC4955670__F5 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer 51741 5971 2355 3726 3725 7975 55859 1936 2353 4804 351 3920 5728 174 283120 2114 27433 4609 10955 2619 2719 89780 1499 648 PMC4957230__F4 Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand 26018 6372 7127 10673 6346 629 9636 64091 79931 3601 6385 11274 7706 29126 4814 415116 4939 25805 9021 10758 6401 79132 3656 5698 25816 3134 64167 114548 11213 6890 64135 59269 23764 10318 5265 6696 3690 1435 3976 1437 6376 6373 3627 6347 PMC4963951__F2 The roles of monocytes and polarized macrophages in HTS formation 7852 4843 383 6774 PMC4967197__F5 Peroxisome proliferator-activated receptor (PPAR)-related fasting response in heart 7086 1362 3939 6647 1675 10891 7169 1737 5468 5162 847 3032 3030 23474 5465 3033 7295 PMC4974115__F1 Complement in disease: a defence system turning offensive 718 728 1378 721 1356 716 613 975 930 5806 966 1380 7448 1191 4179 1604 2271 PMC4974116__F3 HCV dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy 4283 3576 1942 3627 2633 1520 6364 27113 26227 29978 4071 5698 6662 6241 6648 5271 581 3934 PMC4975578__F2 Immunopathogenesis and Therapeutic Approaches in Pediatric Celiac Disease 100507436 3458 3600 7054 3718 PMC4975672__F1 Xenobiotic Receptor Activation: Direct vs. Indirect 1950 1956 10399 23426 PMC4979452__F2 Mitogen-activated protein kinase (MAPK) signaling pathway 1950 2247 2322 1956 5979 2263 4690 9138 2059 22821 5922 2888 2885 2886 2887 2549 9462 5906 6654 6655 5616 5595 7186 5605 5606 9261 466 2114 467 8202 6722 6670 6667 572 PMC4979452__F4 PI3K-AKT (phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT) signaling pathway 7124 3480 4804 3481 1956 2263 8717 5728 9138 51074 PMC4979452__F6 Protein kinase A (PKA) signaling pathway 2797 1909 2691 5998 5999 5922 186 5906 5837 1644 624 623 4193 3356 PMC4979452__F7 Cell adhesion 7076 5327 960 4897 5728 7204 1398 4685 1499 2534 5062 5058 2241 4162 2670 58494 PMC4979452__F8 Cytoskeleton remodeling and axonal transport 9353 348 7852 84894 84628 4976 4741 9138 3265 4744 23380 4082 998 85021 1639 10540 9855 5879 2670 PMC4982039__F1 Hypoxia‐induced changes in mitochondrial metabolism 158 4118 5163 5091 11113 48 50 3417 3418 PMC4985183__F3 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer 1499 4609 3845 1956 472 324 1756 7248 207 1786 1432 25836 5591 7084 1616 5747 5426 4605 11335 51592 10036 9656 2146 5925 4752 6621 142 55596 8805 1108 7508 7486 7520 367 5966 1788 5371 10155 11198 5885 6839 4176 22938 5610 150696 1387 8021 27043 6117 4171 9113 983 8986 6184 5563 5926 8031 3297 595 2289 5781 27347 5451 8554 4175 PMC4985183__F5 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer 7018 4609 7157 1956 324 11200 5747 1756 472 9612 1616 5426 5591 4605 7248 1499 5925 4217 2146 7520 5371 5451 22938 5883 1387 5934 5563 7027 4176 6117 983 1017 5926 10155 8021 PMC4986275__F4 Representation of the top Canonical Pathways, Functional Annotations and Upstream Regulators detected upon analysis of target genes and their co-regulated genes 3596 7124 3586 6774 7040 3458 2099 5788 3398 3399 3487 5698 1956 355 3600 6352 3937 59 3587 1439 3115 2335 1234 4261 834 719 51311 7076 10673 940 3111 7098 55970 64581 PMC4988688__F3 Activation and molecular crosstalk amongst signaling pathways 6608 1956 5728 51684 8313 1499 1950 673 4040 4041 PMC4989157__F7 HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling 994 995 7465 8289 PMC4992261__F4 5 nM PhIP activates STAT3-mediated transcriptional regulation 23452 3952 10631 10628 249 6774 6288 6446 1958 PMC4993794__F1 Tarp protein mediated signaling pathways implicated in chlamydial entry and development 445347 6714 6850 6654 7410 2059 10006 PMC4994014__F3 Immunoglobulin (Ig) production 942 29851 604 3718 3716 958 695 613 PMC4994463__F4 “Inhibition of MMPs” signaling pathway at 1, 4, 7, and 14 days after nerve crush injury.Differentially expressed genes are shown in red (up-regulated) and green (downregulated) 2 7078 4313 7077 7965 7980 7079 8434 PMC4994475__F1 Network of reported candidate genes associated with GTS 114781 57502 266553 58512 29119 219927 9378 83992 8452 6507 114798 9992 1815 26468 7529 26047 5664 5663 3172 3753 4609 11222 5465 148 1812 152 1814 1827 3067 PMC4997298__F6 Upstream regulatory analysis of weight-loss–associated genes identified strong C/EBPA activation 10555 5274 6319 8829 2052 5493 1050 3952 5226 7414 31 187 7280 47 PMC4999498__F2 Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells 7852 960 972 25 4067 6850 79930 29760 387 260425 5728 695 2475 5336 1794 998 572 5911 2922 7015 9590 847 324 54518 2099 4208 3066 6672 25942 2885 930 PMC4999690__F1 GM-CSF and IL-6 signaling 3717 3716 6774 1025 4318 PMC4999974__F7 PAC-1 enhances the apoptotic signal as induced by cytotoxins such as doxorubicin 581 718 790 PMC5007556__F1 SPATA2 – Keeping the TNF signal short and sweet 7124 81858 1540 8717 9825 7186 207 10000 29110 8737 197259 29766 80309 55749 6198 22998 60412 5971 6774 PMC5013308__F4 Pathway map of quantitative comparisons of metabolic proteins in DLD-1 cell lines 6513 2539 3099 3101 25796 10606 471 435 2618 6120 2821 5198 5471 5631 51071 7086 5211 5213 6470 6472 6888 226 229 5723 3417 2746 2744 2194 29968 2597 2747 2806 3418 5230 5232 47 26227 1743 1738 3421 5223 50 8801 2023 3939 3945 1431 6390 1737 2271 4191 4190 5226 48 PMC5013308__F5 Pathway map of quantitative comparisons of metabolic proteins in RKO cell lines 3098 10606 471 435 2618 6120 2821 5471 51071 7086 5213 6470 6472 229 226 5723 2194 2806 48 3418 5230 5232 47 1743 1738 50 8801 2023 1431 5162 1737 4190 6513 6476 3101 5226 5198 5211 2597 2747 3421 6390 2271 PMC5014091__F1 Wnt/Beta-catenin upregulation in CRC and PDAC 55959 1856 324 2932 8312 2736 1499 999 PMC5017307__F1 Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy 374654 51684 6608 5727 156 56623 23432 2121 132884 8500 5144 PMC5021578__F2 Genetic Alterations of D-Catenin/NPRAP/Neurojungin (CTNND2): Functional Implications in Complex Human Diseases 999 1499 367 2932 324 998 6010 PMC5021733__F1 Negative regulators of Toll-like receptor signaling 7099 7097 4049 7096 10333 7100 54106 7098 8651 54472 7189 1843 7187 3661 4615 4118 PMC5028860__F1 Red nodes indicate the query proteins and the proteins present in the dotted circles, VTN, PRKACA, RELA, EP300, AKT1, EIF2C1, are the common proteins associated with the query proteins 434 4852 181 5443 5566 5970 7448 23493 9474 2033 10533 8828 5228 7157 23378 10524 4904 2048 7422 23326 3791 7423 6678 3490 7148 PMC5029635__F14 NFKB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression 355 3661 6352 6347 8717 841 842 836 8772 PMC5031419__F4 Non-overlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi 7157 3815 999 6714 5728 673 572 4193 4286 1019 1869 5925 PMC5036404__F1 Schematic overview of the intrinsic and extrinsic arms of apoptotic signaling 7124 8717 7186 1540 581 572 637 596 4976 8772 355 PMC5036404__F2 Schematic overview of the molecular pathways involved in necroptosis 7124 8717 7186 197259 1540 3466 7098 8772 PMC5037386__F5 Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light 1956 196 9817 6714 405 1545 1543 218 1544 7361 2938 1027 57491 8717 PMC5037530__F1 The gSkM transcriptome for the comparison of HFD-ED and HFD-corn oil fed mice 95 1374 1376 37 34 33 10449 4709 27068 1349 4711 6390 6391 4726 4713 4716 1737 5160 3421 3417 4967 8803 PMC5038066__F7 Proposed model for Leishmania donovani-mediated host TLR2 downstream signaling 7096 7097 4513 4773 PMC5039377__F4 DNA-damage response pathway-network 545 472 4683 4609 466 7374 4436 7508 5111 1643 6117 7507 PMC5039670__F3 Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research 25805 4090 4089 3458 4091 4092 9978 7057 64750 57154 6500 4087 4088 1874 6667 1616 387 6093 10468 5308 4838 PMC5039670__F4 Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research 1021 1019 472 1017 545 1869 4609 355 841 637 581 4193 842 836 94005 64065 7249 3486 5728 2475 6477 64326 PMC5040593__F3 Four pathways for double-stranded break (DSB) repair.Nascent DSBs are first recognized by ATM and the MRN complex that initiate a series of DNA damage response events that aim at arresting cell cycle and recruiting DSB repair proteins 55183 672 142 9156 10038 7486 5893 675 7515 7518 PMC5041020__F1 Leptin and jak-stat in cancer 3952 3082 7422 1950 8743 6420 7124 4313 3479 7040 2691 4318 7042 857 3717 6774 6772 6776 2078 4609 7157 5925 1958 2033 581 5728 5291 2475 914 596 5747 PMC5041099__F3 Integrative transcriptomic meta-analysis of Parkinson’s disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson’s disease 90273 4646 2246 3344 3984 10410 10135 1072 25797 26228 6583 136 1902 9966 6013 6283 597 366 4828 6648 23178 8718 1073 54434 4054 3142 8807 3554 1071 1803 7850 3606 8809 100 57134 4123 23295 2641 6934 6374 8743 1499 83937 353514 8772 841 10681 3579 8462 355 4332 7538 5552 8837 1958 64581 1959 3726 2354 1616 25942 9592 197135 2353 4790 219931 PMC5041313__F2 CB1 cannabinoid receptor signaling and regulation of neural stem/progenitor cell proliferation 6714 6774 5909 2932 5080 PMC5041887__F7 Cell polarity signaling in the plasticity of cancer cell invasiveness 998 387 5728 389 57216 57154 114793 PMC5045062__F2 Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism 2632 2997 5236 3099 226 7038 26227 5223 3939 5163 47 48 50 3418 3417 PMC5047222__F1 Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression 930 2549 3716 3611 6247 3667 9846 8473 10724 5163 2305 4193 PMC5051268__F2 Multiple Faces of FGF-23 5251 1758 5167 286 5741 56975 2260 8074 1594 59272 PMC5054603__F4 Gene expression changes in the elements of postsynaptic signaling cascades 5894 5594 4905 5579 5170 9495 2893 2892 9463 2890 83988 1175 2906 5578 2902 2900 2562 2899 94235 2783 9568 5330 54331 2792 1145 2793 2787 1144 1146 2774 55970 2771 2773 2770 2788 2790 PMC5056151__F2 Transport proteins in Alzheimer’s disease 4363 9429 10347 5243 4035 348 19 PMC5056381__F8 The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus 2695 2932 1499 6934 PMC5061729__F1 EGFR signaling pathway modified from MetaCore® 1956 3480 5335 5747 4690 867 3717 2885 6714 6464 PMC5061805__F1 Fast action antidepressants activate mTOR 627 2475 5163 29904 PMC5064021__F9 Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals 3566 6778 55004 3662 383 3586 PMC5064863__F5 Endocrine related Hippo Signaling Pathway 10207 154796 64398 23513 60485 4485 9113 26524 166824 374 3689 174 4092 2246 268 3398 3397 8313 85407 4609 1499 324 6657 329 332 PMC5069771__F2 Genes upregulated after RSV infection 10673 219285 3447 6355 1991 1116 3240 50604 12 7124 4317 6352 4283 4318 669 6354 710 10068 3576 4057 3586 7018 3934 1669 10562 718 7356 2920 3458 3569 6351 3600 7032 9636 6373 2209 929 3824 3106 10410 3965 11006 4680 7103 3820 9180 8519 4615 24138 1088 8727 64108 2205 3135 27074 9289 64231 9381 306 10578 3312 57126 4939 4353 5551 2766 246 5698 4938 3002 51191 79838 91543 5696 51327 129607 4940 759 6283 1667 847 345611 9111 5610 2634 11274 4792 6252 8638 212 4586 2633 4843 115361 9447 79132 4599 3045 100187828 51056 3434 94240 1616 85441 51316 7421 83666 3669 6773 199 10537 10189 3665 7520 4000 5204 4600 467 3725 116071 PMC5070717__F1 GSK3B in TLR4 responses 7099 114609 4615 7187 7189 29110 10454 23118 2932 3661 PMC5072448__F1 Molecular mechanisms and signaling pathways of ferroptosis 23657 3315 3658 2512 2495 2879 7417 7419 80221 1431 10162 2322 2182 6520 PMC5078078__F6 NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling 4088 1437 5894 1440 5971 8740 183 4055 3551 2353 7189 4791 8795 8772 7535 54472 2002 1958 4049 8517 1956 5610 1435 3458 29110 5595 7124 207 29775 9641 10392 939 8743 3725 3654 7133 6574 7187 4214 6955 84433 2475 5649 PMC5078657__F2 Cancer pathway targets affected by curcumin 7422 2735 5727 6469 2067 9429 595 891 2475 7852 6774 3383 995 996 581 1958 1956 PMC5079533__F4 Ingenuity pathway analysis of endocrine networks depicted in through 9049 6696 5251 6569 9365 846 5972 632 6258 796 7421 2263 2260 1591 1636 2776 59272 3643 154 8862 3630 408 9370 2778 7352 3952 7200 3953 PMC5085687__F5 Molecular mechanisms of osteoporosis in ACTH-secreting pituitary adenomas 1392 284 6696 5654 84890 2885 85451 4772 3725 100187907 PMC5085707__F1 Stages of cancer cell colonisation of the bone 7412 7448 846 3589 7852 6387 2621 999 1000 PMC5087126__F2 Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways 3455 7297 3716 7098 51284 4615 51135 7189 7187 3654 8717 6773 5971 6774 257397 29110 3665 3663 10379 3661 1440 PMC5088563__F1 Signaling cascades implicated in developmental cell death and tissue homeostasis 596 2879 7099 7098 6774 8737 11035 999 PMC5088662__F4 MAPKs, TGF-beta and TNFA dependent pathways involved in GFNs toxicity 7124 4092 4089 4087 4088 581 PMC5091087__F5 DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HIPPOCAMPUS PROTEOME AND METABOLOME PROFILES IN ADULT OFFSPRING 1892 2026 908 1808 2023 5223 5315 5230 4905 4191 63908 PMC5095918__F2 The Fanconi anaemia pathway 2159 675 51455 PMC5095918__F5 LUBAC and UBE2L3 regulate NFKB response 7332 7124 3553 81858 PMC5101451__F1 Signaling pathways of TLRs 7099 54106 51284 7098 114609 4615 51135 7189 7187 3656 3654 29110 23118 257397 3665 3661 PMC5103369__F6 Regulatory roles of the Arg/N-end rule pathway in autophagic flux and protein aggregate clearance 4137 3064 8878 11101 PMC5108086__F3 Toll-like receptor signaling pathway color-tagged by co-morbidity findings 7096 7097 54472 100187907 8772 3929 3565 929 114609 7099 1356 958 5132 51311 51284 1513 7187 2885 126669 51083 7074 998 3702 387 1398 10235 PMC5108628__F1 Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity 6611 57506 11274 103 8772 29110 3661 PMC5110160__F10 Acute Simian Varicella Virus Infection Causes Robust and Sustained Changes in Gene Expression in the Sensory Ganglia 2316 11047 396 333 4155 79641 9625 4097 29924 8861 7392 5589 2783 79885 5119 7376 6663 6657 23492 84687 5168 11240 5986 84445 6909 6721 2670 2286 3297 220296 28964 5881 126669 5170 29904 9770 2260 PMC5118094__F3 Environmental enrichment regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) 2885 6908 2002 147 146 148 185 553 1131 552 3269 2790 55970 2791 2782 2783 3358 3357 54331 2784 59345 10681 3356 2787 2785 2788 1445 2767 9630 2769 695 PMC5119498__F1 Factors Implicated in Insulin/Growth Factor-Induced Regulation of Mammalian or Mechanistic Target of Rapamycin (mTOR) Complex-1 (mTORC1) 7248 7249 6009 2475 8408 7942 64223 PMC5122694__F1 IPA Canonical Pathway analysis showing the interferon signaling pathway across the NC vs 3458 3716 3717 7297 8651 6773 10379 581 5696 4599 PMC5127022__F3 A diagram of host factors involved in MeV inducible stress granule formation and autophagy 57120 83939 57506 345611 9140 581 7072 1999 PMC5127598__F5 Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model 1017 472 545 355 637 4609 836 94005 842 4193 7249 3486 5728 6477 64326 PMC5129526__F1 Transcriptional regulation of glucose metabolism during active TB disease and in PBMCs stimulated with Mtb 226 2026 2027 2597 2821 3098 3099 3945 5211 5213 5223 5230 7167 47 48 1431 1737 1743 2271 3417 3418 3420 3419 4190 5162 6389 6390 6392 8803 8802 8801 3606 8649 2475 3667 54681 6888 5209 5166 5163 5165 3939 4191 2182 2181 2180 51703 644096 4707 57097 84875 54625 83666 64761 PMC5129950__F1 miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1 55003 472 545 4193 648 4089 4088 4149 993 1017 3084 6839 25942 PMC5130074__F1 Scheme depicting the possible mechanism of VEGFR-2-mediated vascular effects (cell proliferation, survival, migration, and enhanced permeability) related to vascular formation 6714 998 6461 572 PMC5131988__F2 Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy 6432 64854 100132406 6154 8536 4116 6188 6144 8527 6894 55884 6136 2289 10857 8490 4493 2052 8301 5534 1793 1356 PMC5133374__F4 Immune response_IL-17 signaling pathway 4312 112744 84818 3716 7189 3383 3717 847 1431 6667 6354 PMC5133678__F7 RBM5 targets in the EGFR Signaling pathway 3164 7249 23239 2309 2308 4303 842 1026 2931 5170 5136 5582 572 57761 5137 801 23035 814 5578 1385 117145 5580 5153 5568 5566 5573 163 160 161 1211 8027 6868 10252 6464 10253 6654 286204 7529 4893 3265 5894 3845 998 983 5604 102 2549 5781 1445 3716 8038 4117 5595 5594 PMC5133788__F10 11-epi-SA-induced apoptotic pathway in HA22T cancer cells 581 637 572 7186 83939 468 3725 PMC5133817__F1 Argon’s molecular mechanism 7097 7099 4615 581 51135 2475 6774 PMC5137220__F1 Summary of genetic and pharmacological evidence implicating Wnt signaling in developmental cognitive disorders 4040 4041 5728 324 2475 1499 PMC5143325__F1 Reactions induced by oxytocin 5020 5021 2776 4012 51393 5747 4878 1147 2353 249 5728 5970 2475 54414 5581 9373 PMC5146691__F1 Implications of cell biological processes on innate immune signaling 929 7099 9447 3661 3659 PMC5148031__F5 Developmental Stage, Muscle and Genetic Type Modify Muscle Transcriptome in Pigs: Effects on Gene Expression and Regulatory Factors Involved in Growth and Metabolism 9242 1499 650 6932 4088 7494 406947 6662 1959 51274 55294 1487 1488 1879 4331 9869 2303 5947 3091 406 9575 23175 4776 26580 2167 3952 5346 4023 9474 10628 10533 PMC514912__F7 Model showing the cooperation of the BLM and the FA pathways in the response to replication arrest induced by either DNA crosslinks or UVC and HU exposure 641 4361 2177 PMC5149546__F7 Putative triterpenoid saponins biosynthesis pathway in A 431708 3422 3652 PMC5153335__F1 KRAS pathway biology 673 2475 23463 9986 PMC5159445__F2 MetaCore Immune response_IL-17 signaling pathway 4312 112744 84818 7189 3717 847 6667 6364 6354 6347 PMC5161407__F4 Nuclear DNA damage signalling to mitochondria in ageing 60673 9776 8408 65018 355 8772 841 572 637 581 836 317 842 472 55332 23411 7249 PMC5161695__F7 Glucose metabolism reprogrammed by overexpression of IKK-epsilon promotes pancreatic tumor growth 2932 5105 3099 5313 5211 7167 7086 5230 2645 3939 PMC5166530__F2 CTHRC1 in multi-signaling pathways 7474 7481 89780 7471 652 115908 4920 4040 4041 4086 4087 387 1499 4318 1798 6657 PMC5167032__F2 Dysregulated Toll‐like receptor signalling associated with advanced age 7099 7096 7097 4118 3569 51135 3654 3656 7189 4615 PMC5173167__F1 Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy 3553 5091 4609 6347 6374 6387 383 4318 PMC5179328__F3 TLR signaling pathway and ENU-induced mutations that impair TLR-dependent TNF or type I IFN secretion 11234 84062 121260 81622 29915 1445 5066 7097 7099 4049 7100 51284 54106 7098 7096 10333 948 929 3663 3665 114609 4615 51135 440275 7187 3654 6850 7189 29110 23118 10454 3661 197259 10379 7124 79651 3659 PMC5182153__F1 Insulin Receptor Signaling Pathway Targeted by Surgery-Responsive microRNAs 6810 3643 6844 867 2549 1398 5728 9021 2885 5163 2534 7248 572 2475 5140 2887 47 1977 3991 8178 PMC5201051__F7 Schematic depiction of aspects of adult olfactory GBC regulation 4087 6657 3280 429 4762 10381 648 4975 PMC5204211__F1 The status of Nrf2-based therapeutics: current perspectives and future prospects 9978 4094 571 8452 9817 PMC5204325__F1 Cross talk between the transforming growth factor B (TGFB) family and Wnt signaling at multiple points 4088 324 4092 64750 57154 1499 4089 PMC5204344__F4 let-7c and miR-10b target multiple genes in regulatory networks 401541 7204 84930 51773 4212 1612 1108 1875 4091 993 9149 9252 4173 51053 131405 5950 220 1382 10763 3815 9611 6382 5310 53615 1488 3383 171023 PMC5207552__F1 Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin–Beck disease 8321 2192 11140 2953 3487 51655 3320 3479 578 1612 10631 596 7157 3485 598 8678 581 4170 638 839 10018 28996 572 PMC5209629__F8 Inflammatory players implicated in lipopolysaccharide- (LPS-) induced M1 polarization of N9 microglial cells and of exosome upregulated microRNAs 7099 7097 3146 114548 834 3553 383 1524 PMC5210527__F4 Insulin signaling pathway is significantly enriched in human cycling genes (the hypergeometric test, p-value = 9.70E-7, E-ratio = 2.26) 3630 3643 867 2885 5163 5164 2475 2308 2002 1977 435 355 PMC5214845__F3 Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors 4118 4615 7189 3661 PMC5215973__F2 Deubiquitinases in breast cancer 7874 9100 4193 9958 4087 4089 10533 83734 581 1643 1647 4292 8239 9099 2176 355 51426 1540 29761 2932 324 1499 5970 51592 84196 PMC5216741__F6 MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis 10961 445 10551 5053 3856 3880 1509 1397 4942 1072 10135 29968 1892 6624 4116 5106 7167 7358 1382 3569 196 3172 3420 5111 2475 10935 10549 6648 1737 PMC5220089__F4 IPA-mapped CVD pathway for the 1890 compounds distributed in the top 10 herbs 63923 1800 9344 1611 171392 6714 338442 5743 10316 PMC5220431__F2 HH signaling pathway during development 6608 2736 2737 51684 91653 PMC5220678__F2 Loss of Axin2 can cause MVD by shifting TGFB/SMAD3 pathway toward WNT/Beta-catenin and BMP signaling 7043 650 7040 652 7048 659 7049 324 4090 4086 4088 1499 4091 4089 4092 PMC5222515__F5 Methodology for Cancer Therapeutics by Systems Pharmacology-Based Analysis: A Case Study on Breast Cancer-Related Traditional Chinese Medicines 1132 3791 1131 4843 1129 4846 1128 2908 367 5241 5292 1956 54115 6256 PMC5224520__F7 Bridging topological and functional information in protein interaction networks by short loops profiling 57122 1029 7040 1387 10592 9126 5933 4087 4193 5591 472 10274 1874 4089 5885 147841 7027 6502 2932 9700 6500 7272 7157 5925 4609 10744 7709 10459 701 10393 991 29882 699 9184 10912 2810 10971 993 1017 85417 1019 902 595 1022 51343 990 8318 25 494551 23594 8555 1869 10926 4172 4171 4999 4173 23595 5000 8317 4175 1107 6873 5424 5557 5928 5983 6118 23212 2068 4683 2316 1639 6119 6117 4627 4628 5901 1104 4436 8766 5898 5707 5701 7277 9861 5709 5682 5684 5683 4200 5500 3054 6651 10713 7514 11319 9525 7298 PMC5228426__F2 Most highly-rated network of microRNA-1297 target genes in Ingenuity Pathway Analysis 4671 1009 4916 1356 3479 5728 80263 9627 1540 5925 4603 4208 10795 1997 4211 6310 80314 11244 PMC5228603__F3 Reparative inflammation takes charge of tissue regeneration 7474 89780 3589 4040 4041 4920 4919 6010 9113 26524 324 1499 6774 PMC5228698__F1 Diagram of genes in the PI3K/AKT signaling pathway 7248 7249 1977 64223 2475 57521 6009 5563 5562 6194 6198 6794 5578 5585 5586 29941 4846 2885 6655 6654 672 7097 7099 2997 2998 3667 5879 6850 5106 5105 2538 117145 2932 3492 4609 5170 930 118788 595 1026 1027 51074 1017 1021 1019 5934 11140 5728 5747 200186 356 10018 23035 23239 598 596 572 842 4170 6256 3164 4602 4193 9965 8074 8817 2253 2258 27006 2252 2251 2249 2255 2250 2256 2248 26291 2246 2247 2254 26281 2259 2257 4803 8823 1950 1944 285 1435 5154 56034 1942 51378 284 3630 80310 3082 1943 3479 5155 4254 1945 3443 3440 1442 3452 3448 3558 3451 3444 3442 3447 2688 3565 3449 3441 2056 3445 3562 1443 3446 3456 2689 1440 1946 1284 1280 1297 1278 1292 1298 1286 1291 131873 3574 5008 1277 5617 3909 7058 10319 3914 3918 7059 2335 284217 7057 3915 5649 3911 3913 22798 1101 1311 3912 3908 7060 2260 2263 1969 3381 6696 7448 3643 63923 4804 3371 5156 3815 7450 2264 3791 2321 7143 2324 2261 7148 1436 3561 3560 3676 5618 3674 3678 3570 3566 3455 3559 3563 3675 3454 3575 2690 5159 3673 2057 3672 7010 9180 9170 1902 8515 2149 3679 3680 22801 3685 1129 3655 1128 8516 2783 2785 10681 57121 2788 2846 55970 2791 2782 59345 2790 54331 2786 51764 94235 2784 2792 2787 10161 2793 5516 253314 5529 55012 5528 5518 5523 5522 5527 5519 5520 5526 5521 55844 28227 5525 894 9134 7531 7534 9623 898 7533 10971 3326 896 7532 7184 1388 468 PMC5234110__F7 Schematic representation of the suggested dynamic effects of PGE2 on naïve and primed microglia 7099 7124 4513 2539 PMC5239434__F1 NADPH: new oxygen for the ROS theory of aging 3417 10840 4199 160428 3418 10873 25902 57716 PMC5240660__F1 Phylogenetic and conserved synteny analysis of PTH related proteins 8544 79961 11329 5741 25778 113091 221476 9911 5744 6428 285848 401258 51513 23787 PMC5241894__F7 Insulin-like growth factor receptor 1 (IGF-1R)– and mammalian target of rapamycin (mTOR)–induced alterations upon the canonical IGF-1R signaling cascade, mitogen-activated protein kinase (MAPK) and receptor tyrosine kinase RTKs in Ewing sarcoma (ES) 3481 3485 3479 8544 2885 3667 5728 7248 253260 2475 7249 6009 4088 1977 1938 PMC5247608__F7 Model depicting roles of Sufu in chaperoning Gli functions during Shh signaling 374654 51684 2736 6608 2735 2737 6469 25942 10284 5727 PMC5249073__F4 First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms 7097 5879 54472 114609 10333 8772 3929 929 23118 7189 7099 958 923 5132 51135 3665 130749 1513 54106 3661 7187 7098 8027 10379 2670 2475 PMC5253683__F8 GA13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3Beta-NFATc1 signalling pathway 7189 10672 718 387 4772 1513 PMC5256122__F1 Representation showing the mutations associated with the RAS/RAF/MEK/ERK pathway observed in melanoma 2776 2767 5728 673 4893 2475 4286 1021 1019 4193 PMC5259907__F2 The network of cell apoptosis regulation induced by DNA damage 472 545 581 PMC5260790__F3 Differential methylation network of schizophrenia 63978 9228 60678 55758 4880 2971 8802 11216 10533 4881 102 3192 80728 4335 92667 8821 2521 7091 391 55509 27067 2861 2356 340419 3229 79577 25825 641 10672 63891 6932 29079 1181 129563 79802 55754 57674 10267 91603 4705 4700 9815 57794 5579 3207 5799 27252 9759 3198 2194 29123 64207 3660 5437 54468 126626 79692 826 6885 90427 122830 79269 6155 9127 2783 440 10489 6908 26098 23431 2004 178 818 2355 51202 4628 8895 100526737 6608 84872 1978 29766 203068 6469 3708 10200 283571 196743 261734 26574 11315 10963 51293 PMC5273810__F6 Network analysis using key molecules in VL pathogenesis 5777 23512 23476 4609 2932 10818 8754 5604 7186 7189 1870 3611 2263 6452 6850 6657 84733 5331 4067 1871 79923 1786 23118 1385 1956 6667 5728 3725 3479 3716 2249 2885 8651 847 331 3659 3394 2254 3082 1017 860 3976 3458 6774 8772 6772 3265 3717 3091 8717 3598 7535 3667 6778 3566 5580 PMC5278824__F1 Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives 210 7390 7389 10058 1371 5498 2235 PMC5283822__F3 Ubiquitylation events during TC-NER 57654 7874 8451 9978 1642 5947 4734 54617 7353 PMC5286794__F1 Regulation of key cancer stem cell signaling pathways by epigenetic mechanisms 4040 4041 324 1499 3065 22943 8726 2146 11171 23512 3280 PMC5286880__F5 Interferon signaling pathway as differentially regulated by ZIKV and HCMV in maternal-decidual and fetus-derived chorionic villus tissues 3458 3717 7297 10581 3430 3437 581 8519 PMC5287080__F2 Transforming growth factor B (TGFB)-induced activation of c-Jun amino terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling, and the IKB kinase (IKK) pathway 64750 4092 7189 4087 4088 4091 4089 PMC5290526__F7 A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs 1000 999 100653366 PMC5291233__F6 Impact of pridopidine treatment on BDNF signalling, AKT activation, and the glucocorticoid pathway 627 4915 8660 1051 1026 3164 4193 54541 2819 1958 9456 1843 1959 23237 5166 4792 2353 PMC5294827__F4 Sexual dimorphism in the axonal signaling pathway 4099 4803 5364 2064 3688 4804 387 27289 998 PMC5312537__F6 Changes in upper glycolysis, glycerolipid metabolism and pentose phosphate pathway during aging 3099 2539 2203 5214 6888 226 2819 2820 7086 2597 PMC5314727__F4 Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma 4311 57669 6566 64423 5357 1525 54443 81624 9133 29127 10112 51512 9522 306 5836 9493 147841 445 9737 11057 79801 586 6474 11231 5412 5121 144455 54101 24137 10771 1058 259266 55839 1062 2491 83540 29899 9022 163183 147372 3082 4052 10653 4118 858 387914 290 8502 5329 9180 9833 9319 1033 8991 3925 5493 79695 5898 9649 51154 6790 699 4288 6491 57139 7371 1503 6241 5037 6624 55215 4739 5189 PMC5315629__F3 Post-excision Events in Human Nucleotide Excision Repair 5111 7515 51426 56852 3980 PMC5320748__F1 Similar signaling cascades involved with neuroprotection for insulin-like peptides and sex hormones 3479 3480 367 3667 2475 2002 572 PMC5323396__F3 Proposed molecular talking points between TLRs, Wnt, and nuclear factorKB (NFKB) 4615 51701 4040 4041 1499 2932 5879 5966 5970 8554 PMC5326620__F1 Dual functions of IRF3 in antiviral defense 3661 29110 7187 7186 7189 581 PMC5327616__F9 BM-MSC modulates inflammation response through mTORC1-p70S6K/mTORC2-Akt Signal Pathway 7099 9242 6774 64223 2475 253260 836 3553 PMC5331729__F2 LncRNAs network in malignant transformation of HCC stem cells 3569 3606 27343 11201 3717 10664 728655 25859 5728 6932 7012 7015 283120 1017 894 1869 100124700 29072 5111 6502 PMC5335506__F2a Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage 51692 9184 4841 10135 6727 7175 8086 3930 6708 5223 1829 2319 51199 23607 5709 7171 140465 9491 8726 2010 9817 103 5825 847 9044 100187761 8663 8665 100 PMC5336341__F2 Proteomics and tracing experiments reveal the presence of previously unappreciated metabolic pathways in mature RBC.(A) An overview of the central metabolic pathways that are reasonably active in RBC in the light of proteomics evidence 27040 3263 84890 2805 47 3417 4118 4190 2752 2271 1491 6573 27430 4144 435 6611 383 5723 4522 6470 PMC5336551__F2 Chronic lymphocytic leukaemia 613 973 974 933 51311 930 4041 929 4615 8737 4067 6850 330 3707 84433 1499 55294 1654 7187 3845 7186 8880 23269 25939 5781 673 2782 5604 4609 54880 1959 3662 9968 25913 472 2130 23451 10482 9203 1859 64328 2000 7514 171023 22806 79184 1106 6209 PMC5336655__F4 Example of a visualisation of a significant pathway using the SetRank package 945 1050 5914 5371 861 865 6688 4629 7490 929 290 3815 4353 4893 3845 PMC5337147__F2a Post-transcriptional regulation of cytokine and growth factor signaling in cancer 3082 7422 7040 7042 1950 1994 7048 7046 1956 2885 2549 10818 572 57154 51527 387 2475 2113 10658 6498 6935 6774 8091 117581 3398 1000 999 717 718 PMC5337359__F1 Interactions between the canonical Wnt/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in colon cancer 4040 4041 3939 1499 595 1362 324 PMC5340232__F7 Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer 1499 324 11259 2932 999 4040 4041 PMC5341015__F6 Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis 4191 5009 445 1373 50 6390 435 383 3419 229 2597 2023 5313 PMC5342415__F3 Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer 4259 2882 2686 4772 5575 6611 5567 9918 920 4257 2953 7516 641 2946 891 10270 5424 6117 675 50484 123099 166929 1380 3566 4720 545 11200 7161 6622 7249 64781 8879 427 6609 5788 642502 894 2812 7143 961 2962 5925 919 3689 1280 3914 11037 3693 2335 2963 2968 6875 7027 6908 1032 5295 5340 6881 9962 2155 64600 5321 5294 351 23647 2243 51 8936 30814 7409 4688 2159 2244 2149 2266 3818 PMC5342554__F8 NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma 4922 6010 1499 999 324 2885 PMC5343325__F4 TGFB signaling pathway 25805 4089 4086 3458 9978 8454 7057 6500 4052 387 10468 4838 PMC5343780__F1 Molecular mechanisms associated with inflammatory and oxidative stress in response to chronic exposure to PM0.1 9817 196 6647 367 5743 405 PMC5346358__F7 Mechanism of action of BNP inhibitory effect on LPS/ATP-induced IL-1B secretion in human THP-1 monocyte 3603 4881 3553 PMC5349926__F2 Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling 887 9077 286262 1786 29110 9314 1789 2353 9759 3845 5347 9055 2861 6300 1844 3915 4170 6648 90427 1021 10018 596 6667 2309 27113 4312 4193 5728 23401 5295 1401 PMC5350732__F3 Gene transcripts associated with sensitivity to gefitinib and EGFR and/or head and neck cancer, identified from the genome‐wide statistical analysis, followed by pathway analysis 9915 3918 5771 4322 2886 6318 2950 2534 3732 1475 5777 7046 154 57018 7039 7431 374 999 6273 5337 1956 3860 3868 8581 2247 6317 1948 2017 1999 11186 2200 7155 4089 5916 5970 7077 1997 1500 7078 PMC5351692__F1 Advances in sarcoma diagnostics and treatment 1950 6469 6608 5728 572 324 2735 2736 2931 1499 3091 4193 2475 PMC5354844__F5 The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis 3718 383 6778 8205 729230 PMC5354998__F10 Integrated genomic and molecular characterization of cervical cancer 3169 211 335 229 3033 7351 3170 5241 8313 21 9687 4731 354 2645 3091 6441 5045 338 2235 3689 7494 3099 3398 80781 6469 5054 6775 409 4609 9261 203068 2495 7078 7442 1981 7812 1311 2064 596 572 4436 5599 5914 6256 5328 1399 558 3458 2697 132671 91768 5580 11059 3084 100 79568 252983 2810 64065 182 3486 83439 3861 7421 2355 23682 6604 7022 64782 2877 2125 10971 3691 PMC5355173__F2 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells 2885 3667 5728 5163 7249 7248 64798 2475 64223 6009 1499 595 8313 PMC5355173__F3 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells 324 1499 4040 5728 581 1017 7157 2737 PMC5356793__F4 Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma 149461 192683 58473 5298 90 10686 10272 84316 9482 93 29 10443 3242 51412 644186 51361 64924 10112 93426 51550 201501 55502 79960 415117 10743 23059 54997 3382 PMC5357492__F1 Interactions of the AKT signaling pathway with the GSK3B signaling pathways 5163 2932 324 1499 5164 5728 6955 PMC5358695__F6 Layered network between sunitinib and myasthenia gravis (MG) 406937 7422 693122 7045 4149 3815 5728 4049 154 1604 4893 1271 2322 3791 367 1380 4609 2324 581 3458 5156 355 1233 5159 3265 2066 3845 673 596 PMC5359278__F1 Schematic diagram showing the mechanism of action of NSAIDs like aspirin in inhibiting the metabolism of arachidonic acid by blockade of the cyclooxygenases (COX) pathway and the prostaglandins (PG) synthase pathway, thus suppressing PGs synthesis 4015 5226 5228 4513 4512 PMC5359687__F6 Heterogeneity in Cancer Metabolism: New Concepts in an Old Field 857 6387 8205 920 2475 50943 PMC5359927__F1 Main signaling pathways involved in vasculogenic mimicry 4838 6997 238 7474 1969 4513 7291 664 4323 4313 PMC5360281__F2 Visualization of selected miRNA targeting events on the insulin signaling pathway (from WikiPathways) 3643 3667 6464 8660 25759 6236 8471 53358 7248 7249 208 6009 10211 10580 2319 867 6812 868 6813 6722 23624 1398 252983 2353 2889 6844 3725 8773 6616 4641 5213 5578 5791 5211 9882 5580 5728 2998 5584 5781 10938 4878 3550 7494 PMC5360883__F1 Diagram summarizing the effects of effector proteins on inflammatory signaling pathways in host cells 3553 7099 8717 4615 7189 23118 257397 2932 2597 6188 7186 114548 PMC5364922__F7 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population 3643 3667 9021 6464 8660 5604 5563 6198 5140 5562 2308 10891 PMC5369312__F4 Pediatric Ependymoma: A Proteomics Perspective 2023 4830 3726 6892 2923 11315 3146 8061 7157 847 7431 811 8626 3043 821 6667 598 4353 9518 6596 4170 7534 10971 PMC5369955__F9 Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway 7942 4758 3920 1508 1514 3916 PMC5370075__F4a Biomechanical relationships between the corneal endothelium and Descemet’s membrane 4485 9113 26524 6010 4018 PMC5372489__F3a Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus 7124 775 3643 6517 3667 5580 5581 8660 5602 5296 3630 1398 31 5801 3845 PMC5372523__F1 Nerve growth factor (NGF) and its Tyrosine Kinase A receptor (TRKA) are involved in several signaling pathways in epithelial ovarian cancer (EOC) 4803 4513 6868 PMC5372562__F2 Interaction and localization of proteins belonging to the integrin signaling pathway and found in samples 2 and/or 3 824 5899 54509 5335 7791 823 55742 5829 7094 378 1399 22808 5908 7414 382 22800 3265 208 472 5747 83660 391 5906 7273 673 9564 5599 5898 5879 5217 4893 5881 998 2885 7408 2934 25 5594 60 10094 2932 5595 8976 10298 375 10096 10097 10093 5880 10109 387 59 5912 4690 389 6237 5063 89941 5062 3845 4638 5216 388 PMC5372562__F3 Interaction and localization of proteins, belonging to the angiopoietin signaling pathway and found in samples 2 and/or 3 6237 8517 5062 3551 4690 22808 10298 5063 5921 332 1147 2885 5747 5781 3845 5296 4791 3265 207 4790 208 5289 22800 55003 472 30849 PMC5373463__F1 Regulatory networks that control intrarenal RAS activity 8074 7421 1499 PMC5375627__F5c Induction of glycolytic and tricarboxylic acid cycle enzymes by M-CSF and GM-CSF 5208 5209 5210 5160 5162 1737 226 230 1431 7167 5230 3418 3419 3420 3421 4967 1738 8801 3939 50 4191 6390 6391 6392 3098 5211 3099 3101 2821 2023 5214 2026 2027 PMC5376429__F2 Emerging signaling pathways in HCC: chromatin remodeling: restricting transcriptional and DNA condensation occurs as a result of histone deacetylation catalyzed by HDACs in nucleosome 7099 196528 9113 26524 4485 4771 PMC5378187__F2 Plant-parasitic nematodes: towards understanding molecular players in stress responses 407043 4881 57716 847 PMC5379981__F6 Model whereby both uracil glycosylases and the Pms2/Mlh1 complex enable A-T base pair mutagenesis with a distinct strand bias 4436 2956 5395 6996 23583 4292 7374 353497 9156 PMC5380038__F2 DHS and PHS metabolic pathways 427 56624 340485 125981 55331 130367 81537 56848 8877 253782 29956 204219 10715 79603 91012 7357 8879 8560 224 6610 6609 55512 55627 392275 PMC5380511__F7 A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance 3716 3845 1021 5898 7046 5290 1871 5899 5879 842 6772 9459 8503 5291 5294 1019 5602 5601 5594 5925 7157 4790 7048 1147 5888 675 5604 998 4087 4088 4089 10928 5599 5295 6774 5062 817 6416 6655 2549 8440 5578 6654 5894 4690 7039 2885 2932 867 4342 PMC5380946__F1 TRIM38-mediated negative regulation of TLR3/4-mediated and TNF/IL-1-triggered signaling 7124 3553 7189 4615 57590 23118 257397 10475 7187 10010 29110 3661 3383 3569 7099 7098 84206 3654 PMC5381727__F2 Roles of Caspases in Necrotic Cell Death 114548 58484 9447 3553 3146 3603 PMC5383785__F5 Depiction of RAS-ERK signaling pathway and primary and secondary connections to substrates identified by time-resolved phosphoproteome profiling 1950 1956 26058 2064 6194 6010 6654 8660 64599 3667 11078 7204 2316 2017 2887 5894 2317 5829 5605 10256 27250 57521 9882 572 5058 79026 4008 6774 8021 23511 7159 5903 4848 9612 116113 10413 3727 2117 7175 3297 9972 57122 10762 7158 4850 3607 8202 6938 7005 6878 2077 6722 27349 PMC5384027__F1 Schematic of the DNA repair pathway 2177 672 5888 9025 165918 9656 472 55183 PMC5384128__F1 Adaptive resistance and innate resistance 2475 6774 1956 5728 238 5311 PMC5384738__F4 Top networks and gene connections.Notes: Literature-based clustering of differentially expressed genes using Ingenuity Pathway Analysis (IPA) after 78 hours of 100 µM corilagin stimulation in SKOV3 cells 5566 7529 4067 1956 351 3122 PMC5385041__F4 Diagram of glycolysis is shown, including enzymes whose transcripts were more highly expressed in GRMD (red) or wild type dogs (green) 3098 2147 55276 5236 2203 5834 8789 2539 669 5230 5226 7086 2023 26503 3417 7378 51660 25874 8402 8604 2805 3418 197257 2806 PMC5386972__F2 MYC promotes anabolic metabolism 3099 3939 4609 PMC5389954__F1 Schema of interactions between the canonical WNT/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in cancer 4151 4040 4041 3939 1499 4609 324 PMC5389954__F2 Synthetic diagram of opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in cancer 1499 2932 4609 3939 PMC5390468__F2 KEGG TGF-beta signalling pathway 10140 9241 9765 7709 220134 25805 4052 4088 1616 387 10468 3623 10392 PMC5391973__F4 The immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity 3553 54472 100187907 10454 7939 23118 929 114609 3725 958 942 4615 3661 3603 3929 5891 3665 PMC5392205__F10 Atorvastatin inhibits the immediate-early response gene EGR1 and improves the functional pro of CD4+T-lymphocytes in acute coronary syndromes 3586 7099 729230 4615 920 2353 1958 PMC5392381__F2 Central BCR signaling network constructed from literature 613 6850 4067 930 29760 5163 695 5728 5336 84433 8915 10892 PMC5393394__F5 Network analysis for the RS fraction proteins with increased secretion upon intracellular LPS stimulation 1893 3514 462 567 2214 929 3123 581 2167 9588 2950 2764 PMC5393410__F3 Cancer Transcriptome Dataset Analysis: Comparing Methods of Pathway and Gene Regulatory Network-Based Cluster Identification 2259 30837 2246 2321 8817 2252 2247 3572 2353 3595 2257 3581 2256 3454 5154 3588 7423 27006 8027 1956 5156 3717 3725 3559 3575 2254 3718 2253 7297 50615 3630 3566 2255 3560 8835 3082 3716 3590 1441 3791 2776 5788 2534 894 919 6934 8322 4316 5467 27040 51176 3977 8660 4215 10254 149233 6517 5293 5290 5598 5584 6772 8399 9846 81579 5170 1759 57580 3702 255189 50487 896 1271 9180 3643 6774 3561 468 1437 26279 3953 5292 6775 399694 27330 6777 391013 8398 6464 5792 1019 PMC5397778__F2 Simplified schematic depiction of the canonical hedgehog (HH) signal transduction pathway within the primary cilium 51684 2736 2737 6608 23432 2932 64399 2619 91653 PMC5398309__F2 Visible model is an excerpt of the KEGG (Kyoto Encyclopedia of Genes and Genomes) FoxO signaling pathway in humans as appears after importing in bStyle 4089 4088 4485 51701 6502 4193 5728 3480 3479 3630 3643 3276 6774 1017 PMC5403593__F2 Cell cycle phases and two examples of independent core pathways in the G1 stage 10413 1499 2695 PMC5405564__F6 Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions 5339 4017 3909 2194 3339 1778 10694 2335 718 7018 PMC5406702__F3 EGFR family members regulate autophagy affecting cancer cell survival and death 1956 7249 7248 8408 55626 22863 7405 9140 55353 PMC5409000__F6 Epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), and Src-YES-associated protein 1 (YAP1) crosstalk 1956 7186 3717 6714 5829 5970 7003 6774 PMC5409774__F5 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) 355 8772 8717 7186 637 2021 4615 317 4803 572 3562 472 581 759 PMC5411428__F1 Proteostasis network and ALS 6647 9217 7494 468 22926 7415 2521 203228 54664 25978 9896 29110 PMC5412052__F6 IPA generated pathway prediction for the NRF2-mediated oxidative stress response in the small intestine 571 3725 468 7415 2512 7314 847 2495 10963 10574 2877 10961 8192 5479 2936 7295 2052 316 4792 PMC5412308__F4 DEGs protein–protein interaction (PIP) network complex and modular analysis 6286 3854 11226 23305 57761 4585 1179 255738 9388 7804 9245 23657 23382 83879 51659 157570 54831 6533 6423 6424 9060 1836 5050 10635 26040 144455 10926 57405 157313 7472 8671 2049 54443 55872 8318 9201 387103 3624 83540 2146 2048 4085 1033 10112 9518 6558 150468 113130 890 6241 634 1062 81930 1058 4211 259266 6662 891 699 9787 343 995 22974 3070 4751 54821 64151 861 1300 284217 7272 9480 1063 3161 1288 8507 56992 3778 221150 3662 332 5450 3815 3002 5579 5742 3170 8038 9156 4493 55722 84823 6947 9211 54959 4319 4320 253012 3673 675 2908 4316 4151 29089 9760 5105 3291 2786 84057 55215 2641 50507 590 64388 5196 5028 6523 4312 4129 6387 2690 5473 6338 2919 2191 4306 5328 185 27199 1902 3977 6373 10874 1116 6920 5268 51082 2770 6363 5831 6372 6335 80131 2920 26031 1674 55600 63928 285195 5354 3294 28234 9590 9499 6820 9076 2172 7366 5284 54997 25890 9075 653808 1164 983 6364 56477 2921 PMC5412370__F1 Specific elements of the canonical pathway for modulation of gene expression that are activated after 15 min of exposure of U118MG cells to 25 µM of PK 11195, as uncovered by “Regulator Effects” analytic (IPA®) 1950 4803 3976 1956 65125 6714 9047 2549 572 2309 207 4609 PMC5414760__F6 Potential role of CBX2 in the regulation of sex development 6662 6658 84733 8321 23270 54361 54881 7536 6736 668 3640 2247 5087 9156 6909 4534 546 7257 PMC5415376__F3 Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma 389941 669 5224 5106 5166 4191 5105 2203 1431 2026 3099 5163 6888 3417 2539 5165 2931 PMC5415789__F6 CeRNA network modulates the PI3K/Akt signaling pathway 5970 1956 6446 2885 3845 5879 468 1977 1975 7422 4609 7157 6009 2335 3667 1019 5728 9180 PMC5415836__F2 Following TLR2-ligand interaction a signaling pathway is started using MYD88 as an adaptor molecule 7097 4615 51135 3654 3656 10454 7189 PMC5418219__F2 Roles and modulations of toll-interacting protein (Tollip) in acute and chronic inflammation 7099 54472 3656 51135 PMC5419568__F5 Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNFA 4087 4088 1021 1019 1017 8772 PMC5421515__F1 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis 4047 7040 3479 2549 3383 7412 7124 114548 10365 2475 3553 1386 PMC5421515__F2 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis 8878 2475 8408 9776 7249 7248 6009 23192 7442 80830 60673 PMC5421515__F3 Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis 4090 4086 4047 2309 57103 2475 664 8408 PMC5423198__F5 Visual representation of the network generated by Ingenuity Pathway Analysis (IPA) 9365 4236 64109 2911 923 7430 4915 1910 2798 5625 23213 5163 1663 2023 6470 5468 3091 5925 4609 3299 10553 7298 10217 4000 2104 10075 2972 10856 84656 PMC5423221__F5 Metastatic niches in the bone marrow 1000 6387 7852 6714 999 2475 PMC5423227__F1 Alterations in DNA methylation patterns as a source of cancer progression traits 4286 7428 596 3417 3418 5156 10664 7422 9595 PMC5424241__F5 Leukocyte extravasation signaling pathway 9524 7006 100124696 4316 5579 10125 3702 4318 960 399 653361 3683 8972 3676 7852 5581 695 5880 7414 7408 3689 7294 1499 4689 58494 27035 2241 85451 4688 4322 4267 5829 4320 9961 4325 1398 4313 5010 PMC5425374__F2 Hsp70 in signal transduction pathways 7189 4087 4088 4092 4089 PMC5431431__F2 DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer 7040 3569 3572 367 5468 1950 10891 4088 3725 9314 79191 284217 4878 8651 214 5087 894 9687 168667 59 6926 3681 3371 6657 4488 2626 4087 9421 5076 51363 6500 4609 1499 9497 4212 1747 8320 1316 6648 5327 64321 1969 3624 5493 3791 1382 2202 3880 3855 4846 3576 4624 154 PMC5432387__F1 Type II Transmembrane Serine Protease Mediated Signaling in Cancer 7113 56649 3082 3678 6714 5879 5880 2475 PMC5432641__F2 Nucleotide excision repair and the ATR-CHK1-mediated DNA damage checkpoint 7508 7507 545 11073 84126 54962 8914 PMC5433721__F6 An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice 4694 7386 6389 4705 4706 7385 4715 10975 10063 7350 PMC5434854__F1 Top ranking gene network by P‐value from the gene list uploaded from the NRI versus Control analysis 10488 466 9191 1385 6872 1024 3400 847 6188 PMC5434854__F2 Top ranking gene network by gScore from the gene list uploaded from the NRI versus control analysis 3383 8811 8620 4923 4886 10454 4118 10803 4615 23620 7099 7189 22906 66008 7316 51135 PMC5434854__F4 Top ranking gene network by P‐value from the gene list uploaded from SSRI versus control group analysis 324 991 1371 6141 6137 9382 4664 93643 7175 200734 23225 23521 1385 344838 29964 1603 10493 6135 9818 9883 PMC5434854__F5 Top ranking gene network by gScore from the gene list uploaded from the SSRI versus control analysis 3091 6667 3082 2885 9436 7074 2534 5879 2886 847 998 5998 PMC5434854__F6 Most significant canonical pathway from the gene list obtained from the esciptalpram versus control analysis 4092 200734 1636 51304 21 1603 4236 221662 6224 1775 4753 6662 344838 151613 9156 84937 983 5119 22834 6257 6204 672 4661 3014 7398 545 84126 PMC5435901__F3 Curcumin plays a protective role at the priming and the activation stage of renal fibrosis 999 3725 4734 847 3383 1236 8877 1499 857 PMC5436301__F1 DNA repair pathways in mammalian cells 672 545 472 9156 1763 55183 142 675 5888 5893 7518 2067 7515 5426 7508 7507 6741 5423 PMC5436301__F2 Interstrand crosslinks can be repaired by replication-independent (left) and replication-dependent (right) mechanisms 672 57697 91442 545 55215 84464 51426 51455 PMC5436728__F1 Deconstructing the Complexity of TGFB Signaling in Hematopoietic Stem Cells: Quiescence and Beyond 7046 6010 4087 4088 4089 7018 4092 PMC5438742__F2 MYCN down-regulation by didymin and based on network analyses of our proteomic studies that focused on cancer-related pathways active in NB cells 4312 571 1950 1956 3091 10928 156 1386 4609 4193 998 6010 2932 PMC5439269__F3 Eukaryotic DNA mismatch repair (MMR) 4436 2956 5111 5426 4292 5395 9156 PMC5441531__F2 The circadian transcription/translation loop is comprised of rhythmically expressed “clock genes” 26224 150465 406 9575 4862 PMC5443707__F1 Coordination of DNA Single Strand Break Repair 4968 142 5423 7515 5111 2237 3978 PMC5443811__F8 Illustration of the chondroprotective effects of sUA and the mechanisms underlying these effects 4312 3553 9507 PMC5445208__F6 Genes involved in B-cell receptor signaling which converges to mitogen-activated protein (MAP) kinase pathway, nuclear factor KB (NFKB) pathway, and phosphoinositide 3-kinase (PI3K) pathway are the therapeutic targets of B-cell lymphomas 6850 695 84433 10892 8915 2475 5266 974 973 3492 PMC5445378__F2 E5 immune evasion mechanisms 325 4513 1956 581 PMC5445378__F3 Interferon synthesis and signaling pathways 1386 3661 6772 6773 7297 3454 3459 3460 PMC5445660__F2 Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras 6472 10797 1431 2821 6513 8861 4005 3099 4194 4193 8493 6520 2475 3480 8660 253260 64223 79109 5045 8131 4899 10641 55768 84301 2176 2175 83990 2189 55215 55120 29089 2178 6683 2188 PMC5446740__F5 Disease module predicted by GLADIATOR for hyperinsulinism 3118 3651 3119 3479 3630 1508 5663 3490 3643 5925 9709 4036 6670 2547 1050 10094 6667 338 335 1071 4023 7025 65264 3172 3990 5465 811 5347 PMC5450035__F1 Neuroimmune interface and the role of glia in the pain response 3146 7124 6347 3458 2475 3554 729230 PMC5452017__F5 Brain metabolism in health, aging, and neurodegeneration 627 23410 4899 7019 PMC5456285__F5 HCoV viral proteins on innate immunity 4615 3716 7297 6772 6773 57506 3661 3659 PMC5461634__F3 Sub-network of cell cycle pathway regulated by C1orf132 and TMPO-AS1 1031 2932 1875 7027 1030 1874 1029 595 5111 896 1028 5934 4609 4172 5933 1021 4174 1019 7029 1032 894 1026 9134 4175 6502 8900 4999 1027 1869 1017 8318 990 5001 898 1871 545 890 4171 5925 994 10926 494551 1870 23595 993 1111 8317 4173 100128191 902 11200 85417 8243 1022 991 10274 9133 10744 7465 27127 7272 29882 2810 9700 8379 10735 1647 5885 64682 891 9126 246184 4616 4085 10393 10912 PMC5462452__F1 ROS in Cancer: The Burning Question 6649 57716 6648 2539 4199 4522 5226 6647 847 3417 PMC5468003__F5 Network analysis obtained from IPA of differentially regulated proteins (p ≤ 0.05) between recurrence (R) and recurrence-free (RF) patients 103 6772 5371 57674 7919 4650 6892 5861 8615 PMC5468628__F1 GRN and SBN circuits 6657 6658 5015 9355 9638 6496 5629 8820 2637 551 7432 2290 4990 2019 7471 7479 652 8543 6469 PMC5469704__F1 Stress-induced EGF Receptor Signaling Through STAT3 and Tumor Progression in Triple-Negative Breast Cancer 1956 999 4318 4316 6774 PMC5470086__F1 Intestinal FXR and TGR5 signaling in metabolic regulation 2264 1593 1581 9420 1582 4280 PMC5470107__F2 Interconnected processes of (i) S1P synthesis and degradation within the sphingomyelin/salvage pathway, (ii) S1P export and (iii) signaling through binding to five specific G-protein-coupled receptors, S1PR1-5 124976 53637 1901 1903 8698 9294 6010 6696 6694 56848 8877 PMC5471512__F8 Insulin resistance in LMC metabolism, inflammation, and contractility 3667 5728 207 208 85451 PMC5482192__F5 Ten differentially expressed genes between human bizarre parosteal osteochondromatous proliferation and osteochondroma enriched in the TGFB signaling pathway 25805 4086 4089 3458 4092 9978 64750 57154 8454 7057 6500 1487 1874 7046 4087 4088 6667 1616 6093 387 10468 4091 4838 PMC5482641__F3 Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder 4090 4086 1282 1082 1520 3248 6768 80781 5645 26872 7374 1356 2707 8519 1675 3665 1777 1992 1050 1001 633 8942 1373 283120 PMC5482974__F3 Protein traffic steps mediated by PACS-1 and PACS-2 382 6868 5045 55690 6850 PMC5484415__F4 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy 2744 4553 8473 83939 468 PMC5485083__F2 Top Left: Gene expression networks activated whilst differentiating cells are treated with varying doses of escitalopram 26586 8871 389 10808 8110 667 1742 230 5423 287 8139 29 1791 27242 5798 6161 5822 29889 9790 25879 PMC5488012__F1 Role of ROS in VEGF-mediated angiogenesis 3091 1003 6714 50507 27035 6774 PMC5489426__F2 Dual role of cellular prion protein in normal host and Alzheimer’s disease 581 2534 6714 PMC5490640__F3 Ubiquitin enzymes in the TCR signaling pathway 920 940 5335 3932 7535 83737 8239 56957 5091 8915 11274 1540 23118 10454 142678 9958 4193 5970 57162 PMC5490640__F5 Ubiquitination in B cell activation 958 7187 7186 7189 56957 PMC5490640__F6 Ubiquitin chains and ubiquitin enzymes in the TNF-induced NFKB and apoptosis pathways 7124 7186 8717 8737 8772 1540 23118 81858 90268 9825 5970 PMC5491788__F9 Intestinal FXR and TGR5 cross-talk in the regulation of GLP-1 secretion, hepatic bile aid synthesis, glucose and lipid metabolism, and insulin and glucose sensitivity 1593 1581 1582 9420 2264 PMC5492169__F9 Schematic model describing the CD99 peptide-induced signal transduction pathway 4267 3265 2549 5300 5894 5782 PMC5494974__F3 Haploinsufficient tumor suppressor genes 1017 1021 1019 4609 3725 1958 472 PMC5498655__F1 Metabolic and transport pathway for irinotecan (CPT-11) 324 1066 8824 1576 1577 54658 PMC5499908__F1 Force transmission and mechanotransduction from the extracellular matrix (ECM) to the nucleus 2444 5916 1499 57591 25777 23353 3930 6010 PMC5504108__F2 Therapeutic targets that regulate YAP/Hippo activity in mesothelioma 6010 4771 6093 9475 9113 1025 983 PMC5504126__F2 Cholesterol synthesis and metabolism in astrocytes and neurons 348 4035 3949 10858 PMC5506042__F6 Number of genes including those downstream of HIF-1 signaling pathway were up-regulated in the pancreas in response to HFD 55364 2246 718 1893 694 596 51129 7077 7079 7078 5270 2060 2202 3791 857 664 7045 7049 5740 8829 9370 1026 1027 7048 7490 25976 PMC5506222__F4 Schematic model showing AA sensing signaling pathways that might modulate neuronal activity of central olfactory areas 8140 6520 6510 55117 54407 57468 4553 846 29850 PMC5508596__F1 Wnt signaling pathways.(A) The canonical pathway is activated once Wnt binds to the frizzled (FZD) receptor and LRP-5/6 co-receptor, thus recruiting disheveled (DVL) protein that inhibits the Beta-catenin destruction complex 6010 1499 3725 324 4040 4041 6259 PMC5509684__F7 Statistically differentially expressed genes 5966 5970 3458 550625 9245 2517 2590 11320 2650 8473 2591 4248 PMC5509726__F3 Protein-protein interaction networks of metabolism related pathway enriched genes 1622 10580 2169 6342 9415 2170 768 324 5468 335 9370 1374 55902 5106 1373 2752 130 5313 5315 8789 93010 3611 2203 3945 64065 8702 10331 3099 3098 226 8704 8703 10402 8707 80201 2527 10317 55276 8126 6484 23474 2530 130589 6482 PMC5516276__F4 Genes uniquely modulated in Fam13a−/− mice are involved in carbohydrate, lipid metabolism, and molecular transport network 26136 148867 56649 7818 3693 6182 1808 57126 5175 65005 1435 5159 4221 1513 25925 89780 4211 84168 PMC5516800__F1 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? 3099 2645 3098 2821 5209 5210 5207 5208 2147 226 229 2597 355 5230 3939 3945 PMC5516800__F5 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? 3845 673 4609 6714 3099 3098 2821 5209 5210 2147 226 229 2597 355 5230 5223 3939 3945 PMC5516800__F6 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? 3099 2821 5210 5209 5207 5208 2147 2203 229 226 355 3939 3945 PMC5522276__F2 HABP2 p.G534E variant in patients with family history of thyroid and breast cancer 3957 9922 10168 9706 5595 80117 26873 55226 400 1800 4162 3308 128674 10202 54843 7145 79147 89848 55699 8291 1649 55183 163732 140862 7515 5986 5315 79776 4436 4692 5789 255631 4750 11011 9919 55157 23654 7272 6929 5105 11099 5796 2780 8532 996 4638 2803 1789 10595 2317 8502 340706 4620 269 57504 4593 1482 1431 9388 8805 6498 1244 4689 4942 PMC5527948__F1 Scheme depicting the major compartments of the endocytic pathway and selected endocytic proteins participating in the transmission of signaling to the nucleus, by affecting the transcription machinery and/or the chromatin‐remodeling factors 1601 2060 274 3092 8650 137492 7251 6642 1499 10370 2002 8178 6749 PMC5528331__F4 MAPK signalling pathway with unstable and stable (copy number and expression) genes represented 9020 4790 8517 3551 140738 759 1843 5566 4137 5580 3925 1849 5582 5924 1846 11221 115727 4914 5590 10125 5583 6197 5594 673 3845 2002 5595 1950 2885 6655 6722 2353 5894 5605 5533 5530 22808 4763 2249 4342 4609 5155 5159 5532 5534 2768 5535 2316 3303 1399 85451 8491 4214 6416 9448 3725 5602 11184 4296 5609 998 5601 5062 1386 839 5494 835 9175 207 208 10000 6788 7786 840 842 836 834 7124 7186 2645 5603 6300 1432 1649 355 1616 4149 7043 7040 7042 6885 4208 7048 9261 929 3316 7189 3315 4216 468 9344 51701 5598 PMC5528934__F2 Genes associated with paclitaxel (A) and gemcitabine (B) mechanism of action (direct targets, metabolizing enzymes), genes previously associated with resistance, and stable genes in the biological pathways targets 28234 90427 581 718 1558 598 572 596 81027 10383 4137 4134 4133 10382 4363 5243 89845 8647 55973 1261 2247 2633 4986 79161 332 102723547 2335 4791 10333 7291 2030 30833 3177 9154 1633 1635 64078 978 7298 51727 203 6240 6241 4830 50484 1503 PMC5529905__F1 Signaling pathway resulting in TNFAlpha-mediated necroptosis, and specific necroptotic inhibitors targeting RIP1 and MLKL 8717 7186 8772 197259 PMC5530465__F1 Metabolism of chemotherapeutic drugs-related gene polymorphisms 5981 2944 4524 PMC5530905__F1 Action of PPARG ligands and p38 MAPK on transforming growth factor (TGF)B1–induced Beta-catenin signaling in corneal fibroblasts 2932 324 999 PMC5538844__F10 Cell mechanisms by which MPLA prevents inhibition of absorption by LPS in the MTAL 7099 7097 4615 51135 3654 7189 PMC5541251__F6 Illustration of AHR activity in pituitary cells 196 9049 405 1543 57491 1026 1027 7018 PMC5541427__F1 Snapshot of PiiL in group-wise view mode, showing the “cell cycle” pathway 7124 472 7027 6668 4609 991 5111 5347 PMC5541427__F2 “cytokine-cytokine receptor interaction” subsection of the “pathways in cancer” pathway, with (a) DNA methylation data, and (b) gene expression data 6774 1956 1950 11186 10125 595 5156 3725 4312 2353 4254 3815 286204 3265 369 5604 4609 2322 5979 2113 3082 1019 2246 2260 10928 5898 10342 5578 5337 5900 5335 387 3716 7039 6789 3479 2885 3576 2323 PMC5542187__F5 Simplified diagrams of putative signaling pathways responsible for the different migration patterns (i.e 4193 2475 387 998 28755 PMC5542201__F3 Effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS) 5163 5728 572 7249 7248 6009 PMC5542661__F1 Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge 126306 142679 5906 5213 54870 6477 64419 1154 85451 8445 9821 104 3265 79134 84548 23545 10969 81563 11183 6002 306 7016 PMC5543726__F2 REV1 and DNA polymerase zeta in DNA interstrand crosslink repair 7508 22909 2177 55215 80198 146956 84464 199990 51455 4436 5111 56852 51426 PMC5545609__F1 Normal endothelial cell metabolismA schematic of the principal pathways in healthy EC metabolism and the rate-limiting enzymes, carriers, and transporters (shown in blue) 2539 5209 2147 7086 355 2167 2744 PMC5546018__F1 NDRG1 inhibits oncogenic signaling pathways by down-regulating the ErbB family of receptors 1950 7039 10397 5879 5058 6774 1956 PMC5547476__F9 Cartoon depicts the role of MYBL2 and FoxM1 in glioma progression 2305 4605 999 1000 1017 595 4313 581 5728 PMC5549626__F2 PLCG1 deficiency perturbs phosphorylation on canonical TCR signaling proteins 5336 5335 3932 3702 7409 8915 998 5966 2353 3725 27040 948 920 940 PMC5549772__F2 Salmonella enterica serovar-specific transcriptional reprogramming of infected cells 23433 613 1154 8835 1316 10135 3359 1942 5971 8651 9021 9180 3437 3872 5743 3726 2697 2633 8519 3669 8638 2034 2353 9935 602 6354 4502 10379 5210 3434 5209 3659 1958 6513 3929 9636 3433 3098 43 2244 2266 9945 3091 6347 10397 3484 2243 2920 1052 133 183 3627 664 6364 85441 7448 347148 51129 3269 338442 3690 27242 6288 10085 5997 6774 3310 3371 3673 6303 7128 330 7185 1907 4792 6367 2921 64135 3656 11221 1906 3976 3552 3725 388 3553 597 3589 5329 6352 467 7436 6373 6385 PMC5552707__F8 Network analysis of the gene pathways* catalogued in the Panther database, which - directly or indirectly - are connected with AD upon activation with Hp(2-20) 9641 8554 2870 5531 3516 348 1981 5664 6868 8754 5966 5537 1977 408 3725 4851 23385 323 2872 4790 5970 6416 351 2358 5728 84918 1495 6934 6199 4214 9306 55615 2932 100462981 6714 5603 7855 2065 1499 2357 5586 5595 5170 7480 2776 5584 868 389 5566 4893 4040 5291 3454 5613 5336 5321 391 7533 2549 5921 10818 5338 5922 6655 81569 81848 10094 10109 10097 10095 10093 4750 673 5588 5516 5599 2359 PMC5553784__F3 Reactome functional interaction network corresponding to 520 genes showing differential expression in the T0 (fasting) vs T2 (7 h after eating) comparisons 8013 10105 64207 23764 55636 54205 9603 9586 9997 8726 6662 7073 6165 5087 23414 6120 117581 54460 3383 1390 6224 6227 8538 10018 22794 10014 2625 9734 7290 7091 1628 5478 6502 8871 7314 70 4628 10010 3150 8864 64386 4620 10450 148523 2246 7139 8651 2048 23072 79094 114609 5596 7097 89 57520 7058 7481 10628 27134 27289 6401 4756 688 1230 4363 1052 1366 6385 114548 467 91653 27123 10999 368 PMC5555610__F2 RAS Proteins and Their Regulators in Human Disease 867 2889 9693 6654 10125 25780 10235 115727 153090 22808 8831 4893 64926 3845 8437 9462 6237 22800 22821 5921 5922 5900 369 673 5894 57139 5863 5294 5293 5290 8844 283455 5604 5603 5594 6196 6197 6195 3725 2353 2113 2114 2002 80824 PMC5561186__F8 Schematic overview of effects of metformin on gene expression and metabolism in human adrenal H295R cells, focused on mitochondria and steroidogenesis 19 2027 2026 230 5106 84532 3418 1586 7351 125965 6770 54332 PMC5561723__F2 To identify coherent networks of genes influenced directly by smoking, we examined the potential interconnections of the 310 genes identified in the genome wide methylation analysis using PPI information in the STRING database 7764 2114 3705 55970 8535 7253 57521 5916 3945 115 10873 5976 5914 23293 11251 55770 5898 4780 10803 396 7204 6497 4739 9938 2625 4088 55920 5724 675 2027 408 7535 6904 919 960 3185 6294 4026 8863 PMC5562757__F9 Mechanistic model for ATF3-mediated negative regulation of antiviral and autophagy pathways in the absence of type I IFN 467 6772 6773 10379 9636 9474 PMC5564444__F1 DNA damage and its links to neurodegeneration 142 54840 55775 11284 5111 3980 2237 7515 3978 PMC5567140__F4 NCL expression affects cholesterol synthesis 4199 3157 31 3156 3992 79071 4597 6319 10654 3422 91734 9453 2224 4047 1718 1595 10682 6309 1717 50814 51478 6307 4691 PMC5569752__F1 ER stress-mediated apoptosis and inflammation in cardiovascular disease 22926 10628 83939 468 114548 581 PMC5571780__F1 Small GTPases in endothelial barrier regulation 387 9411 54922 55698 1499 1003 PMC5572374__F2 Prior knowledge network (PKN) derived from public resources, including interactions connecting nodes which are measured (in blue) or perturbed (stimulated in green and inhibited in red) in the experimental data 3479 3569 1950 1956 3480 367 6774 2475 6194 4609 PMC5572386__F2 Apoptotic and necroptotic mechanisms 7186 8717 1540 637 8772 581 596 197259 790 PMC5573869__F6 Regulation of DNA damage response and repair by Pontin/Reptin 472 10419 672 7528 54617 545 55215 2177 PMC5574901__F2 Most significantly relevant pathways and highly linked molecules (identified molecules from 17 preclinical studies which to explore the potential mechanisms of TLs for pancreatic cancer) relevant to the merged bionetwork 2114 3280 54407 54541 4087 4088 7422 3399 2475 6667 22943 4133 5604 7050 7124 126393 1111 PMC5576886__F1 Impact of Base Excision DNA Repair in Age-Related Neurodegenerative Diseases 7374 4968 252969 79661 55247 4595 6996 5111 8930 3980 2237 7515 3978 5426 PMC5578419__F2 Experimental models of hepatitis B and C — new insights and progress 975 9076 100506658 29881 PMC5580472__F1 Extrinsic and intrinsic apoptotic pathways 7186 253868 637 317 7504 9973 8772 PMC5582379__F3 Five enriched pathways and their contributing DEGs are shown 10592 10051 2491 1058 151246 64105 83540 55839 55920 1062 57405 79172 991 91687 1063 348235 550 7112 10213 7316 7298 7084 5426 286826 4609 1019 1719 1017 6502 4176 6118 4173 5934 5111 23649 1871 64785 5983 84296 5982 51659 5984 PMC5589605__F4 Systematic analysis of coronary artery disease datasets revealed the potential biomarker and treatment target 6929 435 383 6778 1050 2352 23569 3952 PMC5592202__F5 Schematic drawing of the efferent signaling pathway of the inflammatory reflex in the context of the cholinergic system in immune cells 57152 3383 3384 4615 920 1103 762 759 978 PMC5595348__F11 HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection 51284 4615 7189 7187 10454 3661 8411 3553 3439 3916 PMC5595906__F4 Results of PPI network analyis 6595 1915 59 6597 26610 5687 7178 10432 3172 27316 4149 6418 6002 64928 64061 8829 3156 5936 2783 2737 5189 118 81605 6147 51081 249 7024 5531 467 9184 7431 4800 1107 3183 2521 7026 3070 4602 5111 905 1602 7528 5601 23314 54880 7112 9531 8535 1019 7027 10869 4059 4214 7021 892 9921 51729 5347 5595 1641 581 11215 598 6310 29101 4842 27430 6651 10919 6628 10946 11157 5682 5706 26121 9129 5713 51377 6880 9519 PMC5597599__F1 Model Signaling Network 9021 3717 406952 1432 1869 5728 1386 3091 PMC5597736__F1 Interactions between DNA tumour viruses and the DNA damage response 3014 8081 165918 7518 3981 472 9025 545 100188830 6774 84126 PMC5600417__F1 GO biological process and KEGG pathway enrichment analyses of the differentially modulated proteins at 6 and/ or 12 h of treatment with A233 peptide 9100 64859 79035 10856 9521 7415 3329 581 3099 3945 231 3948 4190 3098 6647 5516 5106 5211 10549 9588 9181 1737 1892 2167 4697 4695 3032 3030 38 2207 57506 PMC5601256__F3 Natural killer (NK) cell activating receptor signaling 8480 7535 7409 6850 2534 3932 2885 PMC5606034__F5 GPR and HDAC co-regulation network related to epithelium metabolism 151556 53836 5288 4539 4259 4697 427 5168 4536 6342 29954 92935 56848 669 5335 4541 4128 4123 64132 5986 PMC5618570__F2 Glycans and insulin/IGF system in cancer: an integrated mechanism 3091 8473 4248 3484 3480 207 3479 847 PMC5622428__F4 Network based on a restricted number of genes after selection of topological parameters 7472 266710 596 835 355 7422 8837 5328 58505 PMC5624538__F1 Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis 7124 3934 6347 2920 PMC5625838__F2a Innate and Adaptive Immune Responses in Chronic HCV infection 7186 7189 8717 7188 3661 7187 29110 57506 PMC5627884__F9 Kyoto Encyclopedia of Genes and Genomes and TGFB signaling pathway with changes between adult facial fibroblasts and neonate fibroblasts denoted by color code 25805 4089 3458 8454 6500 4052 387 4087 4088 10468 4838 PMC5629438__F3 Intracellular and Extracellular mode of Toll‐like receptor (TLR) signalling pathways: signalling heterogeneity in TLR pathways arises from the differential recognition of pathogen‐associated molecular patterns (PAMPs) by different TLRs 7099 7097 10333 7100 929 114609 4118 4615 3654 3656 7098 51135 51311 51284 7189 54106 7187 23118 257397 10454 29110 2002 3661 PMC5632457__F1 Predicted target genes of miRNA-34a in renal cell carcinoma pathway [KEGG hsa05211] 2033 6513 1387 7422 7043 7039 112399 7428 5781 5294 208 2549 1398 3082 2885 6655 369 3725 10298 50947 PMC5635482__F1 DNA interstrand crosslink (ICL) repair: Crosstalk between the Fanconi Anemia (FA) pathway, translesion synthesis (TLS) and homologous recombination (HR) 5111 8318 4172 4174 4173 4176 4175 4171 2187 2175 80233 545 7398 2177 57697 55215 199990 80198 5888 PMC5638116__F2 Mechanism of synergistic action of VCN-2 and docetaxel (DTL) 1956 3480 983 581 5111 891 595 1019 6469 1576 PMC5640164__F2 Metabolic regulation of the immune humoral response 2638 613 920 940 930 3566 50615 958 29851 942 941 5728 5163 6009 572 4193 PMC5641881__F1 Metabolic reprogramming in cancer cells under hypoxia 5236 2997 2203 55902 2194 3939 3417 5163 3418 2744 6510 79944 PMC5642700__F1 Systems biology analysis of longitudinal functional response of endothelial cells to shear stress 3066 2355 1869 902 4331 1022 1019 1017 894 1032 4790 2876 2879 493869 50507 6648 5629 7001 10935 7412 3091 847 10549 9588 PMC5642700__F4 Higher-resolution version of with gene target names visible 7004 4286 3725 230 5744 203068 100188776 6256 28987 10365 5360 5916 4150 642 5915 133 2671 338 6722 70 2353 1958 4157 2315 1513 3091 2767 2308 2534 4846 847 2919 2006 1514 1869 27040 7408 1734 9314 1119 467 9212 1959 7018 7422 7012 4585 1437 4050 3481 1846 4613 7124 1462 2022 10135 639 638 6774 637 3918 50507 2068 9510 91543 875 115426 7507 1050 PMC5642705__F5 Macrophage response to cpsA deletion 3456 64135 4600 3434 10561 4599 8717 8772 1763 100187907 4199 7097 913 6347 2919 6351 6354 6367 2920 2921 3552 PMC5644195__F13 Agents that affect the Hippo pathway (Nat Rev Cancer 7204 5728 9113 26524 6010 324 23513 4485 154796 23405 10521 PMC5645395__F6 Illustration of the cooperative regulation of a miRNA module that contains four miRNAs: miR-18a-3p, -320a, -193b-3p, and -92b-3p (pink diamonds) 387 3912 23396 5500 81 2316 2317 5728 7094 5578 7410 64098 595 8503 5062 10298 5058 2534 2889 1398 5594 25759 3265 572 PMC5645534__F2 Overall survival mechanism used by the Apicomplexan parasites in different host cells 3082 7038 1356 8651 2475 572 581 596 3586 4318 6714 7186 6774 5728 1956 PMC5655367__F4 Modulations of adaptable responsive genes in acclimation 2693 4158 2642 2862 7201 2692 2492 4018 6344 7442 1241 978 5021 2690 3952 3953 6865 5618 3630 3643 3667 389692 1950 867 367 6714 1398 685 3725 1839 4609 2885 126669 3084 9542 2475 572 10718 PMC5656035__F3 Proximal components of the TNF signaling pathway 8717 7186 8772 7185 PMC5659737__F1 Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells 6469 7040 6608 5727 324 387 1601 1499 847 51176 7018 1585 PMC5660607__F7 Crosstalk of KDG molecular and network pathways 7099 79930 2885 6654 4615 1794 199 114548 63940 3071 10011 PMC5661609__F1 Dysregulation of KRAS signaling pathway in PDAC tumors compared with that in the paired adjacent non-malignant tissues 3845 5058 5921 5922 387 2770 2771 5290 5294 2773 2475 6714 5728 5747 2885 6654 369 5604 8569 6464 673 5605 2872 5894 5578 5900 5898 10928 PMC5662719__F6 Schematic working hypothesis 59272 10252 114548 3553 3603 PMC5663837__F4 ErbB signaling pathway and its circRNA-related genes 1956 1950 7039 367 2064 6714 5747 1399 27 3725 685 1839 126669 2885 673 3084 9542 2475 2549 2066 10718 572 8503 5291 145957 10905 10956 4397 10277 29979 100187907 55666 581 7466 100506742 267 7326 7327 468 6400 9978 6500 PMC5663846__F1 Kynurenine pathway 8564 23498 2859 5163 196 PMC5666889__F2 A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review 25824 7001 10549 5052 10935 9588 8991 6649 6647 6648 847 2879 2878 2876 PMC5667541__F2 Protein O-GlcNAcylation: emerging mechanisms and functions 7175 914 8473 10724 25942 64841 5238 2582 PMC5668198__F1 Neural Stem Cell-based Regenerative Approaches for the Treatment of Multiple Sclerosis 54209 3082 1524 54106 3479 5091 PMC5672329__F3 Outside-in signaling through class I PI3Ks 6850 6714 22821 695 7006 100124696 5163 PMC5673678__F4 iCOS pathway associated with HIV-1 TAR target genesiCOS signaling in T helper cells 958 324 942 941 29851 940 5879 3932 2885 7409 1445 9846 5728 5163 572 PMC5676072__F1 Sirtuin roles in Hedgehog, Wnt/B‐catenin, and Notch stem cell signaling pathways 1499 324 2932 22933 51339 23411 6423 604 54880 51548 PMC5677022__F3 10-miRNA-score predicts defects in the HR pathway in ovarian cancer 5728 56946 672 472 545 2177 675 5888 1029 4763 2305 5347 11200 7157 898 595 894 891 207 673 9212 5925 208 994 332 PMC5682418__F4 Selected miRNA-mRNA interaction networks involved in T cell receptor signaling pathway 1493 920 3932 867 2534 7535 10298 27040 3702 2885 3458 10125 1019 8915 29851 940 5163 PMC5683946__F2 NMD degrades mRNAs encoding UPR components 83939 22926 468 467 7494 7186 83856 81572 581 PMC5684252__F1 An overview of signaling nexus of autophagy pathways 7942 8408 9776 9140 9474 10533 3920 596 100170220 664 55062 PMC5691655__F1 DNA damage repair (DDR) factors regulate cccDNA formation, expression, and degradation 79677 23137 51567 51426 5429 PMC5693908__F1 Inflammatory signaling pathways in hematopoietic cells and potential therapeutic targets for myeloid malignancies 3569 3458 3455 3460 114609 8717 4615 6774 7189 6773 10379 1386 7186 PMC5695117__F8 Proposed model for the autophagy process during E 22863 2107 5728 7942 7249 7248 3916 6009 PMC5695813__F5 Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells 2073 1022 5886 5887 7508 4350 7374 1069 7515 6117 10038 5426 3980 2956 5981 9156 5983 PMC5700831__F8 Depicting the possible molecular mechansims by which MitoQ prevents alcoholic liver disease through modulating ALDH2 posttranslational modifications 7099 217 50507 PMC5700962__F13 Wnt signaling pathway pathway(red, up-regulated) 51701 324 4089 4088 25805 50964 6477 6500 8454 387 9475 27130 PMC5703970__F4 Neuroinflammation pathway and therapeutic modules 351 4137 5350 107 3356 572 836 2798 4313 5580 6714 4843 4846 998 3315 4015 5743 5742 PMC5706744__F1 Mammalian biogenic polyamines and metabolic pathways 51582 4946 4953 6723 6611 6608 196743 6303 1984 1725 83475 PMC5706779__F3 Novel Mechanisms and Functions of Complement 718 1499 1356 7124 6120 PMC5709276__F1 Pathway alterations in glioblastoma multiforme 1956 5728 4763 673 2475 4193 1029 1030 4194 1019 1021 PMC5709591__F5 Interactome of negatively and positively changed genes comparing differentiated NIKS with differentiated NIKS16 cells 3340 4986 10461 3087 10253 85004 6670 5159 7422 213 4791 54829 25 4602 3630 10457 4763 5465 10309 7076 1445 1039 9021 7037 1520 3662 3660 56254 6590 9332 7293 196 5741 83666 6317 51561 6097 2572 2913 64332 695 3958 100506658 6428 7040 3297 596 2796 55486 4313 4017 8850 8600 2520 7078 3265 6720 83855 8553 627 7048 7428 11009 5598 1432 2222 5595 225689 5784 PMC5711019__F9 Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling 5308 2028 3782 23051 7481 847 6648 9118 463 PMC5711528__F2 Interactome of lupus susceptibility genes, constructed using Strings software (version 9.0; http://string-db.org) via evidence‐based protein–protein interactions 55332 89849 4299 1717 3385 721 6932 5338 9887 9474 5515 2213 1380 3586 200424 5579 4688 1445 2475 920 25780 23607 4067 3684 51284 7037 7297 5867 64135 57705 3592 640 7292 26191 2104 1773 3665 221895 4439 6775 639 1997 55024 10019 10320 7332 7128 2842 10318 22807 5634 286046 11277 11127 2280 57521 55054 9140 253260 2212 5578 3394 23057 22806 121260 PMC5711888__F2 A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis 27302 7045 2022 161742 10365 9780 4089 2534 6714 4763 7189 59341 4091 558 5728 6259 7249 7248 8323 5155 2475 7481 23002 998 324 8312 57396 8313 23462 441478 2263 7471 595 4851 4855 182 6422 7424 2277 102 6868 5281 7422 PMC5713364__F6 Network analysis by Ingenuity®Pathway Analysis (IPA) indicated molecules associated with rheumatic disease and inflammation of joint 623 9590 81792 5340 9586 143686 8490 5468 2817 4853 407975 222658 3818 PMC5724804__F5 SIRT6 histone deacetylase functions as a potential oncogene in human melanoma 598 1508 207 3320 7124 1520 83734 578 4864 10533 1201 9140 8878 64422 PMC5729411__F7 Summary of the main findings 8726 324 999 7098 1499 4318 PMC5730046__F3 Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming 114134 6513 2645 3101 5226 2539 2821 6120 22934 7086 7167 2597 5230 5224 5562 5313 5091 4191 4199 2271 4967 PMC5730494__F6 Integration of signaling changes after the induction of BP1 9982 2246 2247 367 5782 5879 5062 11113 5894 7157 PMC5732764__F1 Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model 6303 196743 54498 4953 6611 6723 262 4507 7298 PMC5733947__F4 miR-155-5p and miR-200a-3p greatly influence TLR4 signaling pathways 4615 7187 7189 29110 9641 2033 4087 8517 6688 4790 1326 5604 10112 8726 5605 5595 51170 2146 3725 5970 1021 3661 2353 3439 3440 3553 3551 23118 51135 114609 353376 PMC5737637__F6 NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism 2539 4199 10873 6576 3418 3417 8402 23530 PMC5738879__F9 Signaling pathway in the adhesion of stem cells to bone biomaterials 1101 7448 6714 5058 PMC5741248__F10 Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system 1733 2746 7086 290 2184 7052 10135 3418 55357 4696 57834 9111 7045 972 114793 54518 50807 9208 9397 6774 1646 57016 1645 8644 2729 54578 PMC5741702__F2 Localization of the polycystic kidney disease (PKD) proteins, the pathways implicated in its pathogenesis, and putative therapeutic targets 2717 23193 5589 11231 5091 2475 23411 PMC5742019__F1 Metabolic Strategies of Melanoma Cells: Mechanisms, Interactions with the Tumor Microenvironment, and Therapeutic Implications 4893 5728 4609 673 2194 3099 4522 47 2475 3417 6470 26227 3418 2744 3091 4286 PMC5743771__F1 Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease 2874 6772 6613 7341 8554 3659 19 9619 114548 6850 PMC5746547__F1 PFKFB3-driven glycolysis and the central role of FAO via CPT1a function in ECs (a) Schematic of PFKFB3 as a key regulator of the glycolytic activity in ECs and the angiogenic switch 5209 2147 5629 PMC5747948__F6 Comprehensive molecular biomarker identification in breast cancer brain metastases 338324 79682 80004 54443 10769 3993 9253 5923 55876 1755 286097 6714 81848 58528 23741 54512 2849 1652 5214 4613 5909 27338 6181 6187 57082 900 6788 7272 50937 400506 51203 153241 55722 9249 57631 6594 641 PMC5747948__F7 Merged network based on eight upstream regulators, of which E2f, ERBB2, IL6, HGF, and RABL6 were in a predicted activation state (z-score > 2) and let-7, TP53, and CDKN2A were in a predicted inhibition state (z-score < - 2) 54443 347240 8082 55322 1843 55332 10769 51203 5888 900 55684 7421 5919 7272 79968 9134 664 4254 9768 993 56992 1051 3717 4613 1869 6278 5984 4998 7804 1841 2064 1029 51129 2908 10810 79027 3005 641 9450 2697 64866 1164 83990 84265 8496 PMC5747948__F9 Comprehensive molecular biomarker identification in breast cancer brain metastases 51506 26834 56122 822 8815 6157 6147 25873 27258 5037 51085 64951 103910 6146 1359 51503 23521 55142 23035 6160 51566 4670 7283 115106 7357 10560 2287 64784 1459 10939 4697 5356 5411 1329 6936 333 4724 79101 25915 84419 65991 293 728340 8812 64976 11098 79064 54460 PMC5749411__F5 Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development 4089 652 3458 4091 4092 9978 64750 57154 8454 6476 4087 4088 7045 387 10468 5308 4838 PMC5749725__F2 Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression 23440 4008 29119 1496 387 2241 3480 3643 5594 4088 4089 51701 2695 2064 PMC5751231__F7 Regulation of miRNA expression in response to maternal disease and stress 574492 1870 51592 6722 5592 4625 9759 2353 894 148 PMC5751948__F1 Activation of NFKB (nuclear factorKB) by canonical and atypical pathways 7124 4049 5971 5970 940 5091 8915 10892 23118 10454 PMC5752874__F3 HMGB1 receptor and possible signaling pathways 3146 6503 998 PMC5753009__F3 ATX-LPA axis promotes cancer-related inflammation 4018 6714 387 6774 2475 3725 1386 3091 3603 7015 4318 PMC5754510__F1 Important growth factors and cellular signalling pathways involved in tumourigenesis and angiogenesis of NETs 2619 6608 3667 5728 2735 5163 572 7249 1021 1977 1499 4193 472 983 1017 1018 PMC5757446__F2 Current and proposed molecular mechanisms augmenting myogenic reactivity in subarachnoid hemorrhage 7124 1080 8877 6696 387 PMC5761662__F8 Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase 468 3845 83939 440 467 57761 27163 PMC5764779__F4 Pathway affected commonly in liver metastases irrespective of cancer types 7124 84249 5341 79875 929 4513 PMC5765504__F5 PPARG signaling 58 51129 7421 7098 7471 4023 283927 10555 51085 1536 2820 11343 149685 56667 1375 2170 79071 1622 7169 788 3032 5972 7069 3488 9965 4803 37 34 761 3827 10449 2819 5166 84649 1376 PMC5768349__F4 Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics 8927 220202 782 785 1082 1634 144455 89780 1994 29802 595 11013 2695 7045 8609 150094 6664 54861 1000 51559 23657 5914 5324 5979 1958 100616447 6659 8842 6925 6656 5480 5023 1356 693230 PMC5770079__F6 Apoptosis signaling pathway 355 8717 7186 1616 8772 9451 1649 468 1965 596 581 823 637 7157 317 842 841 4193 331 839 840 836 PMC5770609__F3 Crosstalk between the Hh and Wnt pathways forms regulatory loops 6608 51684 324 1499 2737 2735 2736 PMC5772637__F6 Pathway studio analysis of genes analyzed in the study by the gene array analysis and qPCR 230 10972 84419 5236 8517 4501 51129 842 4794 5970 5209 4790 4792 1537 302 841 2353 54541 836 301 581 7157 133 596 4318 10397 72 664 858 5210 PMC5772637__F7 Pathway studio analysis of proteins whose genes were analysed in the study by the gene array analysis and qPCR 4318 133 7076 10972 72 836 230 596 4082 4794 4792 841 842 54541 5209 5210 5236 142 2353 5970 11018 3162 8517 84419 PMC5774508__F5 DEGs enriched KEGG map of the NFKB signaling pathway in myocardial infarction 3932 142 27040 472 29760 613 6850 4067 331 10892 8717 3929 4781 929 114609 1270 1950 4803 7412 4049 4050 5971 PMC5777890__F7 Reactive Oxygen Species Damage Drives Cardiac and Mitochondrial Dysfunction Following Acute Nano-Titanium Dioxide Inhalation Exposure 4696 4722 4700 4712 4704 4710 7384 6622 4705 54205 1743 4528 3313 27180 10449 11315 50 7316 4967 5163 2180 3032 3688 1742 6389 10131 8802 3767 1345 3316 3712 27089 4719 PMC5779878__F6 The potential signaling pathways used by bufalin to induce apoptosis in SCC-4 human tongue cancer cells 22926 581 2021 PMC5780129__F7 Co-expression network constructed for the signature genes 4745 11247 6658 90634 2220 202018 4004 259 8403 25896 2521 5409 54929 6344 54800 29969 570 55311 6296 4287 4076 63940 7057 23531 7251 6794 1489 9440 53358 55105 30844 335 5105 6169 689 29927 2819 337 10959 51319 79635 PMC5780146__F5 Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the TNF signaling pathway 7124 840 8772 377677 836 1470 83737 182 3569 64127 6401 197259 7186 7187 PMC5784915__F6 Inferring hidden causal relations between cancer and normal networks 5594 1848 5591 1612 208 5595 5052 9978 7532 6197 6794 23291 596 5571 8678 7398 2932 6885 10645 5562 5563 7529 836 80824 6009 23770 7534 5564 2475 207 57521 253260 8945 6199 27250 1975 598 572 54205 27429 6196 6195 5597 664 3320 PMC5784953__F7 Critical comparison of topology-based pathway analysis methods 5640 2885 7039 1950 5915 2064 1956 6256 3845 5290 5336 5335 6257 6654 6655 6258 238 5578 5582 5579 369 673 5170 6789 208 572 3265 11186 207 PMC5788649__F1 Gene master regulators of papillary and anaplastic thyroid cancers 5979 8030 10342 8031 3265 3845 673 5594 5604 7170 7175 5605 5595 10912 1026 581 578 1643 51426 51176 4609 999 1499 6932 6934 5133 54619 645784 286042 283120 493812 207 208 10000 572 596 329 330 11132 824 843 836 839 840 842 8837 1147 1676 1677 3551 8517 9020 4790 4792 5290 5291 5296 5530 5532 5533 5566 167227 5567 5575 5576 5970 7132 7186 331 PMC5788694__F4 Role of ginsenosides in reactive oxygen species-mediated anticancer therapy 2100 653361 1536 2475 9474 10533 64422 PMC5789329__F5a Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach 644 6648 60675 6888 PMC5789353__F2 Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells 6566 55902 2805 4190 4199 3417 6576 23152 2744 2746 PMC5793173__F2 Transcription complexes induced by physiological and aberrant Wnt pathway activation 10413 324 1499 6910 PMC5793173__F3 Crosstalk between canonical and alternative Wnt signalling and the Hippo pathway 60485 4485 92597 55233 6010 9113 26524 10413 652 22943 4040 4041 PMC5793761__F1 Bone morphogenetic protein (BMP) signaling pathway 4256 168667 4035 25805 4090 4086 4091 4092 64750 57154 4089 PMC5794649__F2 FoxOs related signaling pathway in cancer progression and metastasis 7852 5063 4087 4088 5728 6446 999 6935 9839 993 22933 1017 10533 572 693207 PMC5794698__F1 Major communication pathways of the microbiota–gut–brain axis 4852 885 5697 PMC5797066__F3 Decorin and downstream signaling cascades in tumor cells 1956 387 55872 7078 4609 7422 10399 2475 5178 PMC5797330__F3 Endothelial Progenitor Cells for the Vascularization of Engineered Tissues 5091 51162 998 5879 1499 6010 PMC5797779__F1 Biochemical function and regulation of indolamine-2,3-dioxygenase 1 (IDO1) 169355 1690 7453 10352 3620 8205 3458 196 941 942 1493 79923 6777 3169 3170 10664 PMC5798144__F4 TGFB signaling pathway and the differentially expressed genes in both the bare and the TiN-coated NiTi alloy groups 25805 4089 2444 3458 9978 8454 6500 4052 1874 7046 4087 4088 6667 387 10468 4092 5308 4838 PMC5802164__F6 Kyoto Encyclopedia of Genes and Genomes pathway of hsa04622: RIG-I-like receptor signaling pathway 7706 9636 1654 80143 5300 9474 1540 79671 54941 9140 9641 29110 3661 10010 8517 64343 7187 3665 9755 57506 8717 8772 1147 26007 4792 841 79132 843 4790 7186 6885 64135 1432 7189 4214 5599 PMC5802197__F3 CAD backbone network 7057 133 2670 4843 5008 1991 1401 958 7067 3481 7350 5196 51738 2100 3630 7039 1270 56729 2033 8431 4314 4313 5443 3091 8829 3569 1634 7068 1950 4852 10254 7040 5468 6667 2353 7025 1051 367 8440 3976 3082 9672 4353 5328 960 8828 3084 26018 8204 5914 834 5617 4846 7181 2101 6642 5921 7314 2069 7157 8231 8295 50964 84458 23321 3265 867 9612 5970 3952 7316 6247 6464 3845 140885 2060 3606 2022 3716 6597 7410 3717 6647 6294 10253 51561 8660 5295 10188 7031 1437 7494 2324 7424 920 1398 1399 2885 5781 85480 3728 3791 847 3977 285 1907 196 2817 3725 6886 4323 7448 3375 4609 685 2335 7422 6004 1956 29924 8805 2475 56667 868 3055 5290 23624 2260 PMC5805631__F5 Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target 2475 5817 3596 6401 85480 2022 3458 7077 4804 355 999 22943 207 57521 253260 3484 3569 6770 PMC5805998__F3 Functional enrichment of combined differentially expressed gene list in severe asthma across all tissues 100187761 5597 9314 6688 2628 5898 5970 3725 929 7097 6622 5743 6351 3687 6347 6009 4057 7018 1431 PMC5811474__F3 Regulation of Intrinsic pathway by E3 ligases and DUBs 9616 572 56658 324 23321 51366 581 10346 331 22954 150365 PMC5811474__F6 Pictorial representation of p53 pathway regulated by E3 ligases and DUBs 55743 10206 9099 4193 28996 10155 472 5252 51230 10277 55159 54894 7706 7375 581 355 10009 23358 84132 6668 10210 8237 PMC5814187__F8 Dock derived compound against laminin receptor (37 LR) exhibits anti-cancer properties in a prostate cancer cell line model 4172 3838 4173 440 7157 4175 11169 11065 2495 27338 PMC5814839__F8 P53 signaling pathway targeted by hsa-mir-34a in liver cancer 836 317 637 4193 56475 54205 7249 55367 27113 6241 6477 3732 581 4194 7157 1643 7161 8231 143686 64065 1021 9538 1019 355 472 5728 896 64393 545 3479 PMC5817805__F1 The BCR-ABL1 signaling pathways targeted by non ABL-directed inhibitors 613 3717 2885 9846 2475 6608 23411 2735 596 PMC5818881__F9 SYK and downstream kinases are essential to drive inflammation and blistering in experimental epidermolysis bullosa acquisita (EBA) 6850 5329 2357 653361 PMC5820622__F2 Depiction of classical and nonclassical pathway to NF-kB (p65-p50 or RelBp52) translocation activation 2885 958 114609 5894 7187 7186 7189 51135 5971 8717 7091 4615 3550 PMC5821407__F4 Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases 3099 2878 226 230 2539 6888 5223 847 5315 3945 3948 9588 10549 5052 6647 1431 50 9377 4728 4713 6390 1340 7384 4701 4729 1329 PMC5822808__F1 Overview of Hippo-Yap signaling pathway 4771 60485 4485 9113 26524 PMC5823598__F1 Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis 25989 57617 85451 27072 253260 10670 7841 64121 58528 10325 79577 705 201163 57521 9894 25983 11329 6198 6009 9140 5563 2872 10533 2689 5562 2976 7145 80243 1756 5164 84232 4210 5341 93986 4893 6778 3481 29984 79109 10243 114907 638 3791 PMC5824365__F6 String pathway to show the node of PD effects 10018 9451 1387 9314 3065 4192 2033 595 3066 53615 5970 3725 7852 9112 3586 5594 3091 6667 5595 1499 7173 4005 947 4097 2353 2100 6886 7182 6775 4602 354 PMC5824384__F1 Role and mechanism of Twist1 in renal, pulmonary and skin fibrosis 7038 1499 23476 648 2920 999 6387 PMC5824490__F6 Emerging Roles for SIRT5 in Metabolism and Cancer 55364 2539 2936 6647 PMC5827181__F2 Toward novel ways of MALT1 activation? 7186 7188 7187 10892 613 8915 7189 9618 PMC5827530__F7 Gemcitabine/birinapant effects on upstream regulatory proteins 1191 891 1382 1969 2125 22974 26586 3861 118 1854 5328 5493 7454 29108 2194 5825 355 5371 3162 5074 9241 51466 581 3851 5054 2950 PMC5828294__F6 The metabolic changes in the liver of fed and fasted HrasG12S/+ mice.(a and b) Changes in gene expression in the liver of HrasG12S/+ mice under fed (a) and fasted (b) conditions 2539 4199 34 3032 3945 3939 2805 2806 2746 2744 3033 PMC5828413__F2 Coexpression network of CAD genes and metabolic pathway genes 23551 6120 191 5126 471 1607 23057 55759 266722 158 108 2917 56776 107 10606 23205 127833 2572 5522 259232 23305 9348 4134 79966 2618 10690 1719 57026 56895 3706 9833 7372 5427 6241 8836 183 7298 8833 2720 6240 1786 1611 1650 4247 1158 1339 3284 9956 81616 27231 5837 5232 1586 133491 2027 4625 8789 92483 1589 5224 1160 761 51196 1591 119548 4524 119391 1588 4846 8639 60676 4629 23544 52 114805 5860 11164 4397 PMC5828413__F3 PPI network of CAD genes 89797 27185 55622 1072 7844 9904 9570 55137 23345 55759 83943 85479 204801 5522 84790 4836 22808 7092 8190 143872 23551 4482 9833 6597 9956 5793 6311 259232 22834 1445 2122 64759 54622 4842 4524 140733 162963 56776 54331 183 6927 3091 238 1586 3077 105 57521 2917 55691 1591 9223 119391 4046 4774 1611 5069 80312 2242 8672 119548 4134 9811 4642 51061 3839 375056 5126 51196 4846 1012 PMC5831762__F2 Simple diagrammatic representation of the (known) key events in Shh signaling at the primary cilium 51684 2736 5727 91653 6469 2619 2121 23432 6608 374654 2932 2737 PMC5831770__F1 Sonic hedgehog signaling pathway 6469 2736 51684 2737 6608 5727 PMC5831796__F1 Hedgehog signaling pathway 2121 6608 2932 2737 2735 51684 2736 2619 91653 PMC5832419__F5 Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors 5091 2878 7086 2876 2730 PMC5832558__F1 Urinary excretion of citric acid (TCA) cycle metabolites and the renal expression of genes that regulate these metabolites were significantly reduced among participants with versus without non-diabetic CKD 50 1431 3417 3418 48 3419 3420 3421 4967 55753 8803 2271 8802 8801 6389 6390 6392 6391 4190 PMC5833426__F7 Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization 3586 4360 383 6774 PMC5833450__F6 Melatonin-induced signaling pathway 653361 857 2548 5879 581 9474 5091 596 PMC5834268__F3 Identification of prefrontal cortex protein alterations in Alzheimer’s disease 2041 1649 2512 1113 3958 6752 331 3851 563 695 727 796 923 351 250 259 948 4153 285220 146433 7535 3902 5267 4137 5599 4277 2263 2495 5045 PMC5835320__F6 Network pharmacology for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis 10449 1353 306 51253 5558 64359 6263 84986 25803 595 7029 4609 60468 6452 11064 1362 4790 3397 3660 10320 6934 6941 146223 3484 80347 9212 3925 3983 10097 10579 10403 10291 1043 80742 4634 11187 25801 5357 5928 2886 PMC5835320__F7 Canonical pathway analysis for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis 1356 306 51253 5928 10449 79969 64359 6382 6263 2036 84986 25803 22826 6452 4609 11064 60468 1362 10320 4790 3397 3660 80347 11120 6941 146223 6934 3484 1244 3983 9212 10403 51454 8853 10097 11187 8760 1956 10291 80742 25801 6010 4199 595 8612 PMC5838215__F1 Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 5663 5567 51701 27123 1387 1856 1499 2932 8312 1459 1457 1460 8324 4040 4041 4089 1487 1488 6477 27101 9978 387 23002 9475 5880 27130 5879 23236 PMC5838215__F2 Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 5663 5566 5567 51701 22943 1387 8324 1499 8312 1459 1460 4040 4041 4089 896 9978 8454 6477 23002 144165 166336 9475 387 5879 27130 5880 818 5530 5330 5534 5579 2932 PMC5838326__F4 Changes in the hepatic expression levels of genes for gluconeogenesis pathway following castration of bulls 3099 2203 5211 2819 2820 5105 5313 3939 3945 5160 5106 1737 5091 1738 79611 5095 5096 84693 PMC5839385__F4 TAM pathway signaling in innate immune cells 4118 4615 7189 6772 2885 5894 3661 7187 8651 9021 2621 2353 3725 6868 PMC5839951__F1 IGF-1 signaling mediated cell-specific skeletal mechano-transduction 3479 50964 3480 8313 9242 2475 PMC5842190__F5 Proposed pathway for regulation of endothelial cell signaling by breast cancer cell-derived EVs and a function-blocking CD47 antibody 140885 961 6935 PMC5842623__F1 Mammalian target of rapamycin (mTOR) signaling pathway 2475 220441 6502 10641 6396 6520 51719 6794 201163 6249 54541 2887 64798 2932 57521 23175 64223 7124 3551 6009 9894 84335 1977 1975 6194 1147 673 5170 4893 387 5728 2885 253260 3479 3667 3643 55615 6446 4842 9675 PMC5846366__F2 Molecular targets of natural compounds in breast cancer pathway 4512 4513 355 8772 PMC5848464__F1 Regulation of canonical and noncanonical pathways of NFKB activation by cylindromatosis (CYLD) 958 4055 7186 7187 1540 23118 5971 602 5970 595 PMC5850516__F1 Transforming growth factor B activated kinase 1: a potential therapeutic target for rheumatic diseases 3654 51135 4615 7097 10333 7100 7099 7186 7188 7189 23118 10454 8195 3569 PMC5852611__F1 Key players and stimuli in DRP1-mediated mitochondrial fission, both in physiologic and tumor conditions 7341 26168 205564 6612 983 7351 64423 56947 54332 PMC5858571__F4 Schematic of the predicted signalling pathways for HagB-induced MMP production in dendritic cells 929 958 1235 7189 4615 4087 4088 6464 3716 3717 3654 5894 3667 8660 23236 4067 6850 5335 5336 4790 6667 2002 1386 1385 1499 3091 6772 1051 4322 4319 4316 4321 4312 4313 4314 4318 PMC5859169__F4 Alzheimer’s disease pathway and enriched gene ontology with Down-regulated genes 23025 8775 6647 51164 5440 6857 57030 7416 6616 26052 6416 291 5601 7419 998 4712 4729 4711 7326 5879 4722 6622 2774 4701 54205 5530 4706 801 4697 1346 5532 2475 8883 10313 5534 5594 246213 341359 1349 PMC5859335__F6 Relationship between cell cycle and common up-regulated genes identified between cancers 9126 5933 10274 7040 1874 1387 5885 5591 7027 472 2932 4193 7272 4087 6500 9700 4089 6502 4609 5925 7157 10744 7709 10459 10393 1026 1030 1029 2810 1111 699 9184 10971 5111 993 994 898 902 595 890 1019 5347 1017 494551 25 9088 8318 51343 3065 23594 4171 8555 1869 8317 10926 4999 4172 4998 23595 5000 4173 4174 4175 701 1032 1031 1022 983 PMC5859524__F1 Regulation of the cell cycle 545 472 995 581 993 PMC5859839__F7 Pathway o of DXP-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) 7124 5468 3156 695 998 331 3815 5566 4846 3791 7010 805 6401 6300 3480 4843 673 8644 5328 6714 25 3098 5894 5880 3558 1432 55086 3718 8399 6256 3643 204 2100 2885 208 9261 4313 5604 412 5747 2263 7535 1977 6850 387 2475 3932 3326 4318 5781 PMC5859839__F11 Pathway of compound-known target-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) 1129 7124 2353 5530 3569 31 5602 581 4313 2099 6347 3486 6256 2920 4314 5728 3659 596 3099 6401 1950 3643 3586 6696 1147 3553 3725 2475 4846 3791 4792 3565 3558 148 5743 3326 2100 847 983 2002 23411 5328 5579 3320 5894 6476 4843 5578 5970 3458 4609 598 959 3551 PMC5860060__F4 Association network of linc-RPIA identified in co-module 1 4897 6092 6710 1956 1785 1173 7408 8650 10048 51466 6196 613 5962 7430 7204 4478 9612 57522 1387 6714 6655 8828 4089 2033 5465 1879 8648 55740 57521 3133 5778 375790 56963 PMC5861430__F8 Working model of the molecular mechanism of APE2-mediated ATR–Chk1 DDR pathway from a defined SSB structure 6741 5111 545 11073 84126 PMC5861661__F1 p53-dependent cell death pathway 472 581 4193 PMC5863447__F2 Hierarchical clustering analysis of all differentially expressed proteins (DEPs) (812 proteins at p ≤ 0.05 with ≥ 2 unique peptides) 31 3991 2998 399694 2885 5573 2194 56729 347 3083 5265 350 PMC5863732__F3 Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, Metabolic and Disease Implications 23410 1373 5009 383 435 PMC5864729__F6 Schematic summary of mechanisms underlying VRCZ-induced skin cancer 196 405 1543 PMC5866782__F2 Free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines 1000 999 1003 PMC5867295__F3 Canonical Ihh/PTHrP and Notch signaling pathways 23387 3549 5727 6608 2146 2736 2737 2735 468 1300 3280 4322 7422 860 1280 11096 PMC5867295__F4 MAP kinase and inflammatory signaling pathways 3603 948 23411 6667 860 1300 1280 249 4322 11096 2919 PMC5867295__F5 Processes of hypoxia and angiogenesis and the canonical fibroblast growth factor (FGF) signaling pathway and newly acquired insights into their relation to the development of the osteoarthritic (OA) chondrocyte hypertrophic phenotype 4803 4921 1734 3717 3091 860 4322 6662 1280 PMC5868815__F3 In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases 5579 1950 367 6714 5747 2069 1398 27 3725 8440 5062 6416 5602 3845 4609 399694 6654 673 2885 3084 9542 2549 2475 10718 145957 572 5266 2932 1026 867 685 5290 PMC5869526__F1 Interferon-like antiviral response 3466 7297 4615 115004 57506 6007 103 PMC5870609__F5 Differential network of cancer pathway between BRCA tumor samples and controls 28958 2263 10000 23604 54331 5154 2788 9915 7043 7048 3908 3551 5159 7475 196883 1950 7423 4436 1488 112399 7704 1909 2064 6258 3909 5728 1029 5290 5566 650 2768 1910 3675 842 3066 6387 1050 PMC5872597__F5 Celtis choseniana eethanol extract-mediated anti-inflammatory activity 7097 7098 7099 4615 6714 207 208 3603 3569 4513 3553 PMC5874277__F3 Phospholipase D1 and neurogenesis of neural stem cells 3208 998 5337 6774 5091 PMC5874430__F10 Ingenuity Pathway Analysis (IPA) diagram of the cell cycle control pathway 55003 545 4193 648 4089 4088 4149 993 1017 3084 25942 6839 PMC5874668__F4 Angiotensin peptides are derived from the precursor protein angiotensinogen through several enzymatic conversion pathways 59272 1636 367 545 3082 PMC5877599__F4 Wnt and other signaling pathways regulating pluripotency of stem cells 79923 6657 3976 3977 6774 7008 4838 1852 7044 6498 652 6929 9350 5447 25805 50964 9475 387 27130 101180900 3280 7054 5978 51701 847 PMC5877599__F5 Hippo signaling pathway 10207 154796 23513 166824 374 3689 174 4092 2246 4087 4088 4089 4086 3398 8313 85407 9113 26524 PMC5882306__F3 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells 22937 22926 7186 3728 7494 468 2695 821 811 10808 596 267 7415 10682 PMC5891886__F3 Epithelial proteomic networks for TRIM28 high (a) and low (b) ratio cases 10155 581 861 1956 3932 8877 999 2475 PMC5893801__F1 Therapeutic strategies to enhance immune checkpoint inhibitors by targeting tumor-associated macrophages (TAM) 8205 941 942 8685 1436 383 PMC5896702__F2 Biomarkers of resistance to immunotherapy 324 941 942 3902 3716 3717 4193 PMC5900062__F1 Canonical and non-canonical NFKB signaling pathways 613 3952 5336 7186 4615 7187 1540 51135 10892 8915 84433 23118 257397 10454 7189 4790 90268 5971 PMC5901475__F2 Therapeutic approaches for Treg enrichment in vivo 6761 50943 90865 2475 1233 6367 7421 PMC5901897__F2 MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy 6774 2353 3091 5371 2309 PMC5902451__F3 Downstream interactors affected by deleterious SAPs in CTNNB1 and KRAS 3845 8313 10297 5797 8036 1003 56998 1001 5894 5900 1499 1000 51176 999 6934 10928 324 83439 8312 998 5879 2002 PMC5904076__F6 HSPs and double strand break repair 3315 672 675 5888 3297 5111 27343 11201 7518 3981 3978 PMC5908807__F2 YAP is at the epicenter of a signaling network 7039 1839 2870 3673 1956 53836 3845 79026 4582 699 84962 54443 374 6790 595 55165 6374 22943 1907 1021 7430 8061 2305 3485 4853 11004 9493 182 10232 6241 27230 1950 PMC5908807__F4 YAP signaling is associated with unfavorable prognosis for PDAC 1839 2870 7039 3673 1956 53836 3845 79026 4582 84962 6790 374 54443 699 595 55165 6374 2305 22943 1907 3485 1021 7430 8061 10232 4853 11004 9493 182 6241 27230 PMC5908886__F3 Peroxisome proliferator-activated receptor gamma (PPARG) activation 1499 5728 572 581 7124 4513 PMC5909795__F1 Regulation of the core components of the Hippo signaling pathway.Abbreviation: ER, estrogen receptor 4485 60485 9113 26524 6010 9686 7003 8463 7004 7005 PMC5915337__F4 Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer 3845 5728 3667 4089 898 4851 6714 7249 7248 1019 3485 1977 5111 29904 6776 8821 367 2956 57103 891 5888 PMC5917448__F12 1-Deoxynojirimycin on gastric ulcer by affecting NFKB pathway 847 7124 4512 4513 PMC5919979__F4 Proliferation-associated lncRNAs act on at specific functional sites of the Wnt signaling pathway 7939 643911 1499 100270680 3190 100507246 652995 4316 595 PMC5923345__F1 NF2/merlin-Hippo signaling cascade dysregulation 960 154796 389421 4485 4771 4609 60485 84962 9113 26524 10413 9686 595 2305 5332 PMC5923345__F2 Signaling cascades and molecules that affect Hippo pathway signaling and YAP1/TAZ activation in MM cells 2475 4485 6010 9113 26524 10413 1499 PMC5923349__F2 Hippo signaling pathway and the anti-neoplastic immune response 6374 3579 6347 8205 1435 60485 4485 3586 2919 PMC5923349__F3 Hippo signaling immunomodulatory functions 3654 51135 4615 60485 4485 3661 80854 58484 2920 2919 3570 PMC5923349__F4 Leukocyte-intrinsic Hippo pathway functions 387 4485 5872 4023 60485 9113 50943 1236 920 613 930 325 PMC5926502__F4 BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells 7099 929 4615 1386 7083 203 PMC5927619__F1 Enhanced high-level diagram (EHLD) for signaling by interleukins 6464 6654 3717 3718 2885 7297 6774 5781 7189 6772 3586 3606 8195 PMC5938286__F1 Illustration of cross-communication network of BCR, PI3K, apoptosis, and NFKB signaling pathways 613 958 7124 4615 8772 978 8717 6850 4609 84433 8915 10892 637 596 5971 581 4193 5970 2475 604 5728 695 PMC5942524__F2 Organismal Injury and Abnormalities, Cardiovascular Disease, Nutritional Disease Ingenuity Pathway Analysis (IPA) Network 5743 627 4915 6531 4133 5604 1813 1268 1815 613 4049 5243 4988 PMC5943339__F3 Top networks of differentially expressed genes in PTvs.N as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders 9245 79695 2152 29760 1048 51458 634 6707 3860 1087 8470 51316 6947 5645 4314 6678 4925 10631 871 727897 23213 4015 6779 4589 26298 PMC5943339__F4 Top networks of differentially expressed genes in Mvs.PT as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders 10365 6776 4133 5604 3394 11151 915 124 125 7174 2077 2125 1050 1825 4609 23474 151126 1039 57178 7157 51512 5373 64411 27132 93624 58190 10602 57111 PMC5946470__F4 CD44-mediated downstream signaling pathways 3082 6714 4323 4318 3939 3091 1499 5879 PMC5951756__F4 Insulin/IGF-1 signalling map 3479 3480 3643 2549 10818 857 10486 867 858 10487 6464 3667 1398 2885 10603 5728 9846 2889 10938 23301 998 5163 23265 8471 2475 6654 208 10000 572 7248 7249 2931 2932 6009 47 6198 1977 1975 2308 4303 PMC5951947__F4 An illustration of the PI3K mutant, ER+ breast cancer network 5728 2099 3480 2309 4609 1021 1019 1017 572 596 4170 PMC5955995__F4 MAPK Signaling pathway showing expression pattern of DEGs in Ladakhi and Sahiwal cows 4284 5566 4137 5924 5590 4909 5583 673 3845 6655 2353 22808 4763 2768 1398 3725 5600 6300 208 50488 5580 1616 4117 1432 4208 929 23118 51295 51701 1950 10133 355 PMC5961063__F1 Summary of ROS modulation during ECM detachment 960 2730 2729 355 7295 6647 6648 3417 5625 3418 PMC5962649__F4 Historic and updated model of IRS signaling 3717 6247 8660 3667 2242 9846 2885 5640 9021 2887 9820 2549 5163 253260 196 PMC5963710__F7 Nonhuman primate kidney transcriptome in fetal development 5663 51701 4609 324 2932 1855 4089 4088 11197 9350 8945 6500 8454 9978 6477 23002 9475 387 5468 4040 4041 3952 PMC5964874__F4 MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs 4803 627 3240 4351 1950 1956 2885 5894 6722 4342 2316 717 3727 7124 7186 355 1616 4149 4208 929 23118 7189 51295 51701 PMC5965688__F8 Nm23-H1 in cell cycle regulation and apoptosis 595 1021 1019 581 PMC5968197__F6 Dual-lock for G1-phase arrest in unfertilized mature starfish eggs 4342 8318 983 PMC5973372__F1 Hippo信号通路。A：果蝇中的Hippo信号通路；B：哺乳动物中的Hippo信号通路。Hippo signaling pathway 25 27 154796 60485 960 8451 4485 2776 122786 3156 9113 26524 79633 83737 4771 5784 83593 6010 6497 6657 6935 PMC5973839__F1 Hyperglycemia enriches metabolic flux to glycolysis and five principal branches including the polyol pathway, pentose phosphate pathway (PPP), hexosamine pathway, protein kinase C (PKC) pathway, and advanced glycation end-products (AGE) pathway 367 2739 7167 2597 5236 2023 3029 6652 PMC5974435__F2 MTOR and MAPK pathways affect the translatome by modulating the expression of specific subsets of mRNAs 1938 29904 896 23367 7072 1975 1998 27250 468 6502 4361 672 PMC5977110__F2 Main proteins and pathways that influence YAP and TAZ in lung development and tumorigenesis 1950 4018 1956 11186 92359 154796 4485 9113 26524 25 27 PMC5977110__F5 Pathways that influence YAP and TAZ in lung cancer 1950 1956 4018 11186 4485 9113 26524 1499 25 27 PMC5981095__F3 General schematic diagram of molecular events that regulate proliferation, differentiation and the initiation of migration in the SVZ 2534 1020 6656 2043 3280 6657 1499 998 5080 PMC5981095__F5 General schematic of terminal translocation and differentiation in the CP during development 1356 1600 7436 2043 6304 5818 10716 23316 1499 2290 6714 1398 9693 23314 1000 25945 6091 PMC5982750__F1 Fluoropyrimidines pathway 1806 7298 4524 PMC5987911__F1 Logical regulatory network graphs for a mammalian cell cycle network (PN1) and a melanoma-related pathway network (PN2), modified from and 1 in Qian and Dougherty, respectively 991 999 8614 6286 7474 3032 PMC5989870__F1 Schematic diagram 2932 324 1499 130497 6662 595 4316 PMC5991907__F3 PARP1 contributes to regulation of redox-related signaling pathways 6446 2475 4804 3551 572 7018 5608 847 4615 4170 5879 5295 PMC5991907__F4 PARP1 regulates repair of oxidative DNA damages 142 672 3981 4968 5111 7515 2237 3978 PMC5992185__F4 Molecular structure, posttranslational modifications, and protein–protein interactions of the Ski and SnoN proteins 207 208 6497 6790 8841 23411 3065 10419 4763 4087 4088 3725 2623 6495 2140 2274 4204 28996 2737 2736 4089 5371 23314 8463 7003 7005 7004 9821 26524 8554 64750 3622 9113 PMC5992512__F2 Dynamic response of tumor cells to fluid shear stress 4047 658 657 4090 4086 983 PMC5994557__F1 Specific microRNAs (miRNAs) in T helper 17 (Th17) cell differentiation and targets for current treatments 920 149233 50615 3717 4092 4087 4088 10401 3662 8473 998 10294 4089 6774 2308 10140 5728 2672 196 43 7189 PMC5996891__F5 Homology modeling of Staphylococcus aureus phenol-soluble modulins (PSMs) 5682 5683 5684 5685 5689 5690 PMC6003041__F3 Regulation of SREBP1 and lipid metabolism by oncogenic signaling in CSCs 37 1892 35 1339 79923 1355 PMC6006192__F1 The intramitochondrial iron–sulfur cluster biosynthesis pathway (see text for details) 22 81894 2232 100302692 51218 3313 23479 27247 81689 11019 122961 388962 9054 PMC6007953__F1 XIAP regulates apoptotic and inflammatory signaling pathways 7124 8717 7186 64127 8772 331 PMC6008067__F5 Proximity of Bcl-xl to p38, MK2, and RTN4 in platelet function 57142 396 2534 387 6772 225689 5608 6777 7534 3315 2115 6776 6773 9446 4860 6647 10092 7249 207 6778 351 6648 5447 208 3984 10000 6774 9532 27161 3842 10949 PMC6011341__F3 The Base Excision Repair Pathway 5423 5426 5111 2237 3978 PMC6014489__F1 The Wnt signaling pathway 51701 4609 3725 8061 7480 1855 8313 896 4040 11197 6656 5467 50964 10297 25805 22943 4088 4089 6500 27101 8454 85409 144165 387 23500 7471 4772 5578 10023 8607 9978 2239 PMC6021530__F1 Regulatory functions of oncogenic and tumor suppressor miRNAs on canonical Wnt signaling pathways in HCC 100302177 693195 6423 22943 100126320 1499 324 51741 100302142 607 960 864 51701 494333 648 PMC6021760__F5 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer 5587 5170 4067 9891 207 1445 2475 545 472 5347 8408 4751 6790 1019 PMC6021929__F2 Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants 5139 5924 63826 6624 1742 23043 5997 4905 1462 374897 51705 288 PMC6022559__F6 Subnetworks of breast cancer subtypes 4060 5187 4609 3381 8405 2956 25 23236 5797 207 3717 3636 3845 5747 7094 1956 91 84433 4613 7157 5290 999 PMC6024579__F2 Hepatic cell death pathway and liver injury in response to high fat diet exposure 355 7124 8772 836 3553 841 PMC6025071__F1 IDH pathway and targets in acute leukemia 3417 3418 596 581 PMC6026538__F2 Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense 9619 7099 19 948 114548 348 3661 3606 3569 PMC6027159__F8 IL-1BR1 signaling pathway 3553 4615 114609 81858 3654 7189 10454 23118 257397 PMC6027299__F2 Global view and function analysis of the ceRNA network in GC 8767 9156 55215 10592 637 23178 5591 79682 55355 100128191 51514 9493 286190 10797 6502 7298 54443 55839 4976 100873941 4040 7153 3925 5111 63967 7112 7272 64105 6241 80209 4796 2919 63922 7037 57122 9824 79572 5933 PMC6028526__F2 Insulin biosynthesis and secretion 3630 4760 389692 3651 100170220 6750 PMC6029485__F1 IGF signaling pathway 3479 3480 3667 2885 8660 5163 572 387 7249 7248 2475 2002 1977 6722 PMC6031772__F1 Arsenic Trioxide and Thalidomide on Angiogenesis and VEGF in Leukemia 2475 331 5728 PMC6033972__F2 Canonical and non-canonical signaling of interferon-gamma 5894 1399 5879 6778 6774 864 3458 PMC6034754__F4 MicroRNA molecular profiling identifies potential signaling pathways conferring resistance to chemoradiation in locally-advanced rectal adenocarcinoma 100313892 4087 4088 574031 4117 4092 4091 100302142 367 6525 604 22808 613 9839 9313 5789 63916 8544 406905 PMC6034857__F5 Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) 9341 811 7099 929 7097 10333 948 83547 8417 203068 4353 4074 53407 4015 105378220 PMC6035197__F2 Signaling for apoptosis and carcinogenesis pathway differentiation 3566 3558 4090 4092 7042 4087 4088 324 4609 367 2475 4089 7421 581 999 840 839 836 108348016 PMC6037039__F4 Functional mechanisms of lncRNAs in vascular disease 103611157 100874363 83657 100616250 3223 139760 339983 23367 10365 100507392 3552 283120 4193 105375734 6352 6376 3037 728655 55000 693215 440823 2146 1869 7422 999 8877 PMC6039250__F5 NRF2 and the hallmarks of cancer 2539 5226 5471 7086 6470 5723 6472 10797 2194 4199 2730 2729 2744 7295 7352 PMC6039341__F3 RAS signaling cascade and EMT: Growth factors including EGF, FGF, HGF, VEGF, PDGF, IGF act through RTKs and activate PI3K–AKT, RAS-RAF-MEK-ERK MAPK and SRC signaling cascade 1950 5728 6714 5163 2932 9839 6935 64398 10207 6678 PMC6039344__F1 IL-33 signaling 90865 4615 54620 5747 51135 11018 2475 5595 3725 5970 2353 4790 7040 2312 5328 3596 383 4314 85480 374 6367 7124 9619 1030 3569 9173 5111 8600 6361 6356 6347 6401 6364 1437 59307 3565 84666 6369 4843 PMC6040253__F1 Schematic model of the regulation of the Nrf2 signaling pathway 8452 9978 4094 9817 1728 PMC6042724__F3 Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1 2022 92140 7046 5997 4763 3265 7223 2810 PMC6044387__F6 MAPK heat diffusion sub-network: pathway extracted from the TieDIE subnetwork using heat diffusion analysis from the MAPK1 network node 695 5921 1956 6654 2353 1950 3725 2099 867 467 1386 2885 6464 6456 5594 5605 1432 6197 4914 9252 6195 8841 2036 4792 116986 5970 3718 4790 930 9261 3561 5580 4214 5608 7157 PMC6045948__F2 Signal transduction pathways involving c-fos 2002 5594 5595 5923 6722 PMC6046102__F1 TNBC: The current and upcoming therapeutic strategies targeting the mutant proteins or pathways to enable tailored-therapeutics 1956 5728 8821 5266 3845 4763 1846 2475 7157 545 472 672 993 994 995 675 PMC6050292__F7 Dynamics of S1P- and ceramide-synthesis pathway 94101 29095 94103 55331 56848 8877 29956 204219 10715 130367 81537 253782 79603 91012 8560 123099 7357 8879 57704 340485 125981 427 56624 64781 8611 8612 8613 5595 5594 3569 6774 166929 6610 55512 55627 4363 124976 9429 6696 PMC6053314__F5 NFKB Activation in primary CNS lymphoma 10563 613 643 6850 3716 3717 4615 695 6774 6778 3654 2475 84433 10892 8915 5292 11040 597 596 6003 3662 974 973 7189 PMC6054262__F1 O-GlcNAcylation regulates oxidative stress signaling pathways 8452 9817 10724 5970 4303 2308 2730 3162 1728 2729 2495 8878 4199 23657 7296 57016 2941 5690 8644 7428 2539 4193 PMC6056002__F1 Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression 6010 10298 2932 1499 10135 PMC6056651__F7 Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development 8320 51043 23414 64866 27005 146802 58525 114818 10919 6582 90865 2625 79823 29072 3344 3566 7752 84146 2354 54973 8189 864 5079 2113 153090 10943 5926 10428 285 860 9079 5930 29101 23309 57649 51742 55339 64895 5100 861 1559 2138 23583 5076 1380 943 23008 6830 6651 22992 23029 113622 8878 23404 486 9070 5316 3211 55733 25998 23764 10644 169026 5073 22976 8761 80336 55342 22907 54901 4091 10664 57680 5087 58508 1876 8085 1649 1975 10605 468 4780 5610 81501 22926 440275 27102 4297 25926 125476 81887 5393 1654 57418 22809 4772 1960 11016 10044 317649 140886 255967 124944 9464 23269 51230 122953 25894 10466 55129 288 4552 57511 2801 5786 83547 81693 326625 6947 25974 79611 8029 132158 97 134526 284541 6712 114876 6710 166785 64850 4548 2804 9826 160428 4524 441024 10588 83548 23114 25814 137872 501 54988 286 10721 57571 54498 314 4897 PMC6057448__F7 Death receptor signaling 8772 8717 7186 29110 1616 331 637 56616 27429 1676 4000 1677 3984 6093 6709 2620 397 355 PMC6062380__F4 Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD) †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6tx00166a 1652 6648 9615 2950 6449 2624 5478 2597 7274 2923 213 5053 2168 635 5265 1938 5947 5444 5445 30845 2593 3240 3827 84836 51011 2224 396 7263 140805 PMC6063820__F2 Maintenance of a quiescent primordial follicle is regulated by Hippo and Akt signaling 5728 5163 6010 26524 9113 4485 60485 2309 PMC6063820__F3 Activation of a primordial follicle is regulated by Hippo and Akt signaling 5728 5163 2309 6010 26524 9113 4485 60485 PMC6069177__F7 Phosphorylation of the HPV E6 PBM links cellular stress response signaling to E6 inhibition of p53 transcriptional activity 472 545 4193 PMC6070353__F2 Oncogenic Signaling Pathways in The Cancer Genome Atlas 5728 9817 8452 1956 2064 2065 2066 5156 2260 2261 2263 2264 3815 3480 8821 4915 4914 4916 5979 6098 238 2322 3717 5518 207 6654 25 5921 867 54206 4763 7249 7248 6794 6009 5781 6016 253260 2475 57521 7048 7046 91 92 673 369 2077 5894 4087 4088 7157 5879 5594 5604 5605 4089 4193 4194 1029 472 4609 11197 11200 4613 4610 6197 4149 54894 27121 22943 27123 27122 4040 4041 84133 23269 2932 8313 8312 1499 324 83463 10608 4084 4601 4335 139285 1028 1026 1027 6932 7089 7090 7091 7088 5925 83439 6945 898 1869 22877 1017 1021 1019 9344 51347 57551 8642 54798 2195 92714 55294 8454 3714 60485 6788 6789 4771 9113 55233 23286 55534 2033 1387 27255 5784 10413 23418 286204 1454 1453 92737 5664 9611 9612 23013 5927 8463 6423 6422 6425 6424 PMC6070710__F9 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response 54205 355 472 4361 545 891 9133 914 5925 367 PMC6072433__F4 APAP-sensitive proteins related to protein synthesis 1938 27101 6500 6188 1499 4553 8662 55832 6205 6124 3192 6136 2752 182 5595 9076 10576 51014 6396 PMC6073339__F1a Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells 355 5465 595 126129 1374 6714 3158 4953 10365 9572 PMC6073339__F2a Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells 355 5465 1499 5166 7351 5163 PMC6078129__F1 Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment 355 8717 8772 581 637 54623 PMC6078129__F2 Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment 7097 355 637 8772 581 197259 PMC6079365__F2 Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance 7099 4615 3553 355 338386 PMC6085621__F7 Gold nanoparticles and Wnt/Beta-catenin signaling pathway 324 1499 595 4609 4040 4041 PMC6089198__F8 Mutation frequency of selected pathways 920 3127 567 65125 1499 6891 6890 8312 581 841 324 54894 836 840 1488 57680 5728 5290 PMC6089393__F9 PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations 7422 1910 624 340481 51070 4836 6667 847 9397 405 2002 10365 2100 2113 2626 2114 2034 5139 6670 4208 1385 3091 4656 2624 9472 775 PMC6090955__F3 Regulation, function, and targeting of IDO1 in cancer 1493 4615 942 941 3815 3620 324 2475 196 PMC6094051__F6 Models for Golgi fragmentation induced by truncated APC 324 10297 387 6010 PMC6094638__F3 Anti-inflammatory function of tumor necrosis factor receptor-associated factor (TRAF)2 and TRAF3 in toll-like receptor (TLR) signaling pathway 4615 7189 7187 57162 10454 23118 257397 3663 5970 7186 PMC6095079__F3 Findings of network and pathway analysis 7111 3805 3002 10578 3458 3804 5551 598 3848 7049 613 212 9289 4603 2209 3822 PMC6095456__F1 Regulation of innate immune cell function by mTOR 2475 253260 4218 5170 5728 207 208 10000 6446 7249 7248 2308 6009 3099 PMC6096065__F6 Protein-protein interaction network of predicted target genes of hsa-miR-1 7594 100187761 114826 154796 7561 23041 55364 57645 9227 6014 10152 4969 160851 3845 11185 10090 2922 23369 27349 8139 22941 58500 261729 6876 5915 147463 56132 7402 23429 1496 344022 23531 5793 57631 PMC6097464__F6 MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set 2263 27092 26281 4351 5578 10 8517 6237 11221 5971 7124 4149 2316 11072 1956 7040 4773 7042 5728 4208 4117 PMC6097464__F11 TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set 7046 5594 7058 9978 4609 10468 3458 4088 7124 4092 6500 6667 4087 3625 7048 7059 9475 90 64750 3624 7057 PMC6097464__F5 Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set 22798 5578 896 55742 9564 3915 88 5604 3685 3611 7410 5829 894 3673 5728 2534 2316 3910 80310 7057 3918 399694 1956 4633 572 858 2335 83660 3908 330 857 PMC6097681__F4 TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts 7097 5879 3606 54472 114609 8772 3929 929 23118 51135 7099 2444 7189 958 256933 51284 130749 54106 338376 7124 4284 100187907 1513 PMC6098952__F1 Schematic representation for the possible interaction of viral oncogene proteins with various levels of Wnt/Beta-catenin cell signaling cascade 999 324 1499 2932 6714 595 4609 4040 4041 6477 4827 PMC6098968__F1 Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums 5728 5163 8660 3667 253260 2885 4193 572 842 6009 7249 2475 2932 4609 2353 1499 3725 351 PMC6099186__F2 The role played by TCL1 in multiple signaling pathways 2475 613 4067 6850 7249 7248 695 472 7157 8626 7494 2033 PMC6099292__F5 Ubiquitylated sites in proteins revealed by diGly proteomics in PC9/GR cells 107966124 6809 415117 5337 100170220 996 8452 8773 7046 5371 11060 55850 27339 7037 6845 9341 137492 27243 1211 22954 5579 1956 1213 2778 5567 6891 3688 3107 4363 26154 60 1244 1201 20 9230 7251 PMC6099423__F1 Model about the effect of indoleamine 2,3-dioxygenase 1 (IDO1) on the utilization of the main energy sources by activated CD4+ T-cells 3620 324 196 920 1374 126129 1375 PMC6100577__F3 Double strand break chromatin stability mechanisms 142 10038 472 9656 9025 580 165918 641 993 9156 995 983 3980 3978 4193 PMC6102400__F1 Interactions of Lactobacillus rhamnosus GG or LRY (green) with Helicobacter pylori (red) and damaged epithelial cells at the gastric mucosal surface 7124 1950 4588 4512 PMC6103439__F5 Homeostasis, regeneration and tumour formation in the mammalian epidermis 999 1499 2932 4313 3569 PMC6105016__F7 Investigating genetic-and-epigenetic networks, and the cellular mechanisms occurring in Epstein–Barr virus-infected human B lymphocytes via big data mining and genome-wide two-sided NGS data identification 5970 4179 10193 100616180 26575 407054 9575 387066 6047 100302285 293 406961 2353 3717 581 2885 25959 10197 6208 7187 3725 11030 6717 367 407012 406984 100126318 100616348 9474 51510 5660 5881 2147 9997 2896 7042 PMC6106745__F2 Viral carcinogenesis pathway and differentially expressed genes in primary NSCLC tumors 998 1234 3249 387 1232 1233 81 1237 PMC6108862__F4 Functional analysis of transcription factors and genes in dysregulated miR-FFLs 351 1489 3977 5879 387 6774 2626 2353 4609 PMC6112260__F9 Protein-protein interaction networks of DEGs involved in the staphylococcus aureus infection signaling pathway 6209 6217 5813 6132 3105 4478 6130 6125 7531 90268 6713 84617 5140 9815 284996 4621 83460 64838 6955 347688 6418 1457 3108 6191 254827 1675 3125 728689 6160 25873 6230 2316 6136 6203 10521 56604 9477 6208 11269 6234 100653365 9439 11224 718 PMC6113562__F3 Regulation of inflammatory arachidonic acid (AA) derivatives after Leishmania infantum or Leishmania donovani infections 55711 7097 10 PMC6114234__F1 Synthesis, metabolism and anticancer mechanism of vitamin D 1628 1591 1594 1593 7421 759 1499 4512 2475 PMC6115007__F2 Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery 7018 654 3077 PMC6115613__F3 p75NTR and TrkB pathways 627 4313 4318 7204 7074 5879 375 6774 387 7291 3725 57498 PMC6115613__F5 Summary of the signaling pathways involved in cell migration and invasion through p75NTR 627 4313 4318 57498 7204 7074 5879 375 6774 387 7291 3725 4803 1499 6714 51176 6925 PMC6117282__F2 Gene networks involved in a) 'developmental disorder, ophthalmic disease, organismal injury and abnormalities' (score = 41) and b) 'cell-to-cell signaling and interaction, nervous system development and function, inflammatory disease' (score = 21) 367 3725 85451 57335 7419 100132406 116151 6645 3652 283578 57062 55737 84513 83464 139760 2353 836 351 6263 2308 146225 64849 200765 3080 83893 64718 3458 5879 PMC6120815__F1 Innate Immune Signaling and Alcohol Use Disorders 3146 3458 7099 729230 7189 51284 3665 PMC6121264__F5 Putative targets of up-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer, (B) PI3K-Akt pathway, and (C) protein processing in endoplasmic reticulum 9618 1147 5296 2260 595 5594 5894 3688 54541 5747 5595 7533 5518 55970 5516 7184 10961 8720 51726 2923 7415 6500 10277 267 821 23193 29979 29927 55666 6746 51128 6747 81567 PMC6122073__F4 Single-strand break signaling 6741 5111 545 472 11073 84126 51199 3014 PMC6122270__F4 Multiple pathways of CD44/CD44v6-promoted CIC motility: CD44/CD44v6 drive CIC motility by activation of signaling cascades as well as protease activation 4040 1956 7852 1499 6774 6868 102 2669 847 387 PMC6122627__F5 The pathways being affected by MDD and by treatments 4615 1844 9817 PMC6123652__F3 Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments 4361 1763 9156 5888 142 50485 84083 6596 80198 1108 5893 55086 84893 9400 546 2177 675 672 5889 7516 7486 10714 2187 7517 PMC6123662__F2 Brown adipocyte glucose metabolism: a heated subject 155 3099 5226 2194 2819 2997 2998 84803 10555 84649 5105 366 5315 7038 364 360 51660 2180 1431 5091 7350 65057 PMC6127670__F7 Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry 4967 8050 1738 92259 1431 50 5162 8521 116835 6389 10049 85451 3313 PMC6131564__F4 Sub-pathway of the HIF-1 signaling pathway identified on the basis of sub-pathway strategy 9020 388561 55823 1956 5604 2033 3091 112399 3480 5594 81571 284185 405 1978 PMC6135699__F2 Modulating Inflammation through the Negative Regulation of NFKB Signaling 7099 4118 4615 3654 7189 23118 257397 5970 7124 PMC6135699__F5 Modulating Inflammation through the Negative Regulation of NFKB Signaling 7099 4118 4615 3654 7189 1540 23118 257397 5970 7124 7185 PMC6137199__F6 Predicted target genes of miR-125a-5p and let-7e-5p in the Inflammatory response molecular network 3558 3586 85480 7422 729230 1401 10563 7124 5008 9180 3587 3977 80329 29851 5737 3384 1493 55959 5800 923 4363 3684 353376 3815 3687 126014 2358 3683 2155 122809 5724 2588 2242 3704 11213 6300 7185 1432 3718 54476 100187907 5743 1540 51274 9314 4089 2353 5468 9429 6850 PMC6139073__F1 Wingless/integrated (Wnt) signaling pathway 2535 4040 4041 6010 324 1499 PMC6139250__F1 NFKB signal transduction pathway 958 613 3552 5971 5970 4313 3383 7412 4513 4318 595 1017 4609 2919 331 7186 7185 PMC6143528__F8 Action of OR2AT4 activation by Sandalore® and (unknown) endogenous ligand(s) in human hair follicle epithelium 3487 3479 1839 5069 3480 1956 341152 2268 4193 572 581 596 PMC6147150__F2 Pathway and network analyses showing major cellular processes associated with persistence of BD 998 3605 940 3720 142679 1356 3858 4293 85458 55771 5347 51512 84790 22974 920 10403 5275 11130 90381 7295 9055 6790 3692 128239 83540 80896 5732 259266 3833 55075 29767 55504 55635 146909 150468 8631 54210 1606 6513 5650 11187 3574 1830 55872 282616 55620 3861 5753 3851 56649 8777 360 3852 3954 252983 5317 1825 3850 25984 6707 7008 1832 PMC6147766__F2 Role of Helicobacter pylori in the reprograming of cellular and molecular programs related to invasive behavior 5340 6667 999 1499 960 PMC6148320__F2 Helicobacter pylori infection and inflammatory bowel disease 3240 64127 8408 10533 4615 7189 114548 1045 3553 4583 PMC6152083__F10 Part of the PPAR signal pathway 30 1962 4023 948 4973 4312 364 PMC6154708__F5 Epigenetic mechanisms of nanotopography-guided osteogenic differentiation of mesenchymal stem cells via high-throughput transcriptome sequencing 4494 202333 4490 4606 440738 8291 4036 4210 1960 7292 3270 11330 114548 212 4267 5266 10272 3034 4087 4088 7462 3479 1805 364 56937 4320 2796 7226 358 9622 363 1082 57158 25823 10279 PMC6156139__F2 Smad-dependent and Smad-independent pathways of TGFB signaling associated with EndMT 4087 4088 64750 57154 2932 PMC6159944__F9 Schematic pathway representing findings of this study 948 1066 4015 19 355 9619 1593 PMC6163197__F2 Main metabolic pathways triggered by chronic brain hypoperfusion (CBH) 472 664 596 7249 6009 2475 7038 PMC6163247__F1 Metabolic implications associated to ceramide synthesis 948 5163 1674 PMC6163343__F1 HH-GLI signaling pathway 51684 156 6608 132884 2121 5727 91653 2619 2736 23432 64399 596 2737 PMC6163961__F1 Apoptosis extrinsic and intrinsic (mitochondrial) pathways 1630 355 8772 27068 637 581 572 790 PMC6163961__F2 Apoptosis intrinsic (endoplasmic reticulum (ER)) pathway 581 7494 468 7186 83939 22926 PMC6163961__F4 Apoptosis inhibition in cancer 7046 7048 581 572 PMC6167191__F7 Dendritic Spine Elimination: Molecular Mechanisms and Implications 627 572 581 23237 PMC6169995__F3 Differential targeting of genes in the drug metabolism pathway 4259 4258 2329 125 2941 2952 79799 2953 220 128 2947 10763 5813 2328 7366 373156 9446 2949 126 316 1576 4257 218 2938 1555 54578 1562 2954 119391 221 222 1565 2948 2950 1577 4129 4128 2946 2944 PMC6174659__F1 P53 transcriptional pathway 338340 472 5111 3486 4193 1956 7039 581 1950 467 2765 4134 596 PMC6174665__F2 IFNG/STAT1 and IL-6/STAT3 or IL-6/NF-IL6 signaling pathway 3458 6774 6772 PMC6174755__F3 Exosomes can regenerate stem cell phenotypes and convert them to CSCs by regulating the Wnt pathway 11197 2932 324 5879 387 9475 4513 4316 595 8507 9076 4897 PMC6174781__F4 Colon Epithelial MicroRNA Network in Fatty Liver 6209 208 1981 1994 2056 100126303 4313 5590 5624 10961 4314 4323 4312 5499 5515 PMC6176282__F9 KEGG pathway suggested that various targets in p53 signaling were tightly associated with ADQ pharmacological action 1017 472 545 4609 572 581 836 842 7249 5728 64326 4193 1019 637 30062 64065 PMC6178121__F2 Pathway analysis shows apolipoprotein E along with its respective interactions in Parkinson’s disease and schizophrenia pathway 2316 6622 6505 293 718 836 5728 1639 834 351 4640 10755 4741 10105 6733 4087 4036 2 596 7804 1537 7436 3949 4035 5663 PMC6191506__F4 Hemoglobin production and redox homeostasis in erythrocytes 212 210 7390 7389 1371 6647 2235 PMC6192166__F3 Proteomics and phosphoproteomics driven identification of the aberrant regulation of signalling pathways leading to poor patient survival 5159 6464 2885 5335 6654 3716 3717 5921 5579 5578 6772 6774 3265 5894 6778 6722 2353 2002 3725 5602 1398 10580 1793 7791 7145 6714 7408 8874 1445 9815 7414 7094 5829 3611 7410 5880 826 5747 5881 207 208 10000 53358 85366 6010 PMC6193498__F1 Homology-directed repair (HDR) and other pathways for the repair of double-strand breaks (DSBs) 672 79728 5888 675 PMC6195642__F1 AKT/mTOR Signalling Pathway 613 973 974 3667 8660 5728 4067 5163 6850 695 29760 2932 2475 7249 7248 6009 2308 2309 2152 27250 1977 PMC6199354__F1 Ubiquitin modifications in the TGFB pathway 998 7189 387 6497 9314 23327 324 57154 344658 389432 90378 154075 64750 55294 9958 9099 1540 PMC6199354__F2 Ubiquitin modifications in the WNT/Beta-catenin pathway 79971 54894 84133 9101 1540 1499 324 64750 57154 9097 81847 9958 79960 PMC6199573__F1 Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A 1843 4137 5580 5801 5583 3845 673 1956 10763 2353 8243 9184 2033 7040 545 701 472 6502 9232 7531 7532 7533 5111 9134 891 894 9133 1019 324 4171 4172 55388 1869 1870 1875 3066 1876 1871 1874 4134 847 5566 4088 10744 7529 85417 8318 PMC6199630__F12 MAPK and PI3K signaling pathways 3480 2064 2065 6714 3667 6010 998 5728 5163 2475 208 2932 4208 PMC6199630__F6 Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis 472 4361 10111 672 9656 637 4193 581 PMC6200414__F3 Phospholipid-binding tumor suppressor ANXA7 linked to the interrelated FGF8 and cyclin E pathways through Ca/phospholipid signaling in prostate cancer 2002 2246 867 1356 3479 2253 898 2922 3082 5879 2885 3265 2549 624 50964 3708 310 6774 3958 9261 5728 367 6717 2185 1956 335 2520 1543 6697 1384 PMC6209915__F8 Ras pathway was hyperactivated in Sorafenib-resistant SKOV-3 cells 2668 2776 27040 7535 6850 1399 613 2885 2534 22821 5922 5900 9610 5898 998 5879 5906 387 2005 3725 595 1386 1019 3932 PMC6210148__F1 Topoisomerase 1 reaction and inhibitors 7150 55775 142 6741 7515 PMC6212468__F8 Main effects on pathways in the metabolic syndrome hearts (DKO) versus WT hearts and for both mouse models the effect of ACE-I 2309 1387 5465 6722 2353 1958 4205 10725 1385 1386 5970 8626 1050 PMC6213163__F5 Gene transcription pattern related to the TLR signaling pathway in white adipose tissue 4280 54472 114609 3569 929 23118 7189 130749 54106 3661 7098 5879 7124 10333 7097 8772 3929 958 51135 1513 114034 5132 100187907 PMC6213163__F7 Luteolin and Toll-like receptor signaling pathway 6354 7100 968 1436 PMC6213994__F6 Anti-oxidative signaling and anti-apoptosis signaling pathways 581 6648 9817 PMC6214980__F7 Sex-associated function of epithelial STAT3 signaling in K-ras mutant lung cancer 6774 2919 6347 383 6346 PMC6216001__F6 Network generation of CDK1, YWHAZ and PRKDC based on significantly differential genes found between cells with PAX2 over-expression and those that lack that over-expression 3717 132 8573 11183 55930 6850 26130 4649 84896 9353 3070 1195 54464 55589 9833 10592 5710 6197 6790 5591 5925 10558 53944 3480 3646 5836 7277 983 472 27330 29766 5954 22931 2697 5504 6282 7534 347240 55048 121457 857 5318 25814 PMC6216037__F8 Oxidative stress-induced autophagy and endothelial dysfunction 581 10013 596 PMC6220322__F8 Metabolic enzymes that characterize the progression from a normal liver to cirrhosis, which culminates in HCC 2203 3099 5211 5160 229 226 3418 6390 3939 3945 4698 2539 7381 25796 9377 5226 PMC6222792__F5 Pathway networks related to estrogen receptor alpha 7414 83667 3822 64399 1440 440 83729 9002 26227 1491 1431 4137 2475 54541 80319 3624 3399 1717 3400 2222 50814 23643 9415 2353 326625 4312 5865 1843 10164 PMC6224120__F2 Breast cancer signaling pathway 7534 57521 2475 1432 7529 3479 3082 5595 2246 1950 1956 3084 3791 5241 3667 5295 4893 6774 5290 56616 7158 842 329 836 840 8682 142 4137 6850 572 1938 1977 598 4088 2625 4089 367 5266 PMC6230569__F4 miRNAs modulating dendrite morphogenesis converge 387 5879 391 3984 23369 6657 4204 627 57534 406948 100302166 PMC6230982__F1 Metabolic pathways associated with cancer 3099 2147 26227 2729 5223 3939 5163 2194 3418 3417 2806 2744 2271 PMC6230982__F2 Metabolic pathways involved in anticancer drug resistance 3099 2475 6648 26227 3939 2729 2744 673 3945 2194 26136 PMC6231577__F1 Effect of radiotherapy on DNA repair, mitochondrial function, cellular ROS, and EMT 6741 142 472 3014 595 891 2475 57716 999 6935 PMC6232116__F2 Communality network analysis for k-clique 9 596 2247 2353 5970 3952 3630 2033 545 10370 5932 998 6714 5599 4683 5881 1000 7157 1386 6119 7045 10499 4313 1387 1019 8850 5465 4318 472 23054 1017 7156 1950 2885 641 1956 3932 2065 PMC6232116__F4 Significant correlation of degree centrality between the OncoPPi BC network and our BC integrated network (p < 0.05), (r2 = 0.23688) 367 867 2099 3320 4089 3551 2549 4790 2249 3717 405 3561 6654 1021 6774 3082 1499 3716 1956 5599 3630 1432 2308 2534 3725 5894 3655 2353 4609 5290 3685 207 5970 7157 2475 3691 64223 998 1019 5879 2065 2932 6464 595 6714 1147 3558 3667 6198 6794 PMC6232796__F3 mTORC2 in cell metabolism 47 5226 355 2308 3939 5163 2539 54407 2744 8140 PMC6234444__F1 Induction of oxidative stress by a virus infection and genome replication 9817 8452 1728 2539 847 4094 PMC6235178__F1 Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor 4485 60485 9113 26524 PMC6236434__F4 Mechanisms mostly deemed to contribute to the development of APAs 342538 4040 4041 7054 387 324 1499 51176 1585 8645 PMC6245348__F6 Molecular network and proposed mechanism of activity.Notes: (A) The predicted mechanism for the reversal of cell survival, angiogenesis, and inhibition of apoptosis 1956 5728 2475 7422 572 841 999 581 PMC6245571__F2 Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages 6541 6520 383 384 80231 6697 5805 445 5009 4942 2643 435 PMC6245662__F6 Monoamine Oxidase Isoenzymes: Genes, Functions and Targets for Behavior and Cancer Therapy 8829 4128 7422 999 7291 PMC6247401__F6 Proposed role of macrophage LRP1 depicted in diet-induced inflammatory conditions 4040 4041 4035 1499 324 6425 7054 PMC6252330__F3 Regulators of glioma cancer stem-like quiescence in the niche 6387 3082 1950 7852 8205 7474 PMC6253933__F5 Roles of SIRT7 in cancer 100187761 51547 999 10444 983 100420631 4089 6935 PMC6255967__F4 Canonical IRF5 signaling pathway and its negative regulation 51311 51284 4615 51135 7189 6737 3663 3662 23235 4067 64784 1843 7124 3586 PMC6257326__F2 Network view of associated proteins created within Ingenuity Pathway Analysis software for visualizing molecular interrelationships 3276 2745 11331 6772 5599 2936 9636 8942 7157 5886 8517 7124 5696 8631 2670 351 2885 481 8935 624 PMC6258166__F6 Brain hyperserotonemia and Sert knockouts 3725 7015 55128 147040 5595 84203 340351 5594 113220 64064 10195 1361 1956 7035 3479 84236 860 368 9463 6667 162282 50853 7429 124044 1356 1385 8074 284297 26261 6363 154043 651 4350 23418 79961 3351 3355 3990 6777 PMC6260831__F2 Deregulated Signaling Networks in Pancreatic Cancer 5728 2475 3845 4763 673 6009 7249 7248 595 1021 1019 1499 6774 2002 324 4485 60485 9113 55233 7003 8463 7004 7005 PMC6263089__F4 MTOR/S6K intracellular signal transduction pathways in the osteoclast 7124 998 5879 7186 7189 5163 6714 7249 7248 10783 140609 2475 572 1977 4485 PMC6266917__F2 Contributions of activated/recruited stromal cells in endometrial cancer (EC) progression 3082 7852 595 2013 2335 3553 8205 6352 PMC6273666__F6 The possible inhibitory mechanism of ethyl acetate fraction of M 7099 4513 3569 3553 PMC6274312__F5 Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules 50604 50802 85480 5266 27346 3460 960 6300 1543 22872 91543 4790 5970 7157 51295 2099 1263 55922 83933 3014 27244 84289 PMC6274719__F1 Three apoptotic pathways (Extrinsic, intrinsic and granzyme pathways) 3002 3001 6418 1616 8772 PMC6274736__F2 Targeting HGF/c-MET pathway in digestive system cancers by microRNAs 3082 4313 7422 6774 2475 2113 PMC6274739__F2 Basic TGFB signaling diagram along with a program of TGFBeta-regulated genes that contribute to the EMT 57154 387 7189 9618 9839 6935 7291 80004 54845 999 6010 3037 1000 PMC6276890__F1 Canonical and non-canonical signaling pathways of the AhR 405 196 1545 1544 1543 7361 PMC6279925__F4 Network visualization of top primary hits 8643 55124 7422 252983 8497 4967 6643 10810 5499 1196 5467 6865 4922 79068 91442 246778 2650 93183 6423 4794 10243 642 6457 23373 57113 814 3671 997 3759 1432 6403 10750 1808 291 23764 1848 191 7341 109 1616 8837 7976 1588 83594 3490 3560 56474 29945 9518 10645 5315 4336 4350 5288 10941 150696 4720 2829 5810 4920 9975 3489 84444 6608 8553 4174 10766 2274 1733 10312 26281 PMC6281221__F5 Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress 10257 7074 5058 7410 64411 387 7432 759 2695 5894 627 2353 3725 2735 2737 4852 51738 3092 268 6662 5465 572 6010 6262 1080 610 10021 PMC6281605__F2 Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions 3855 7170 6242 4188 4582 4312 54538 595 675 9314 1977 4781 114990 2316 79026 4193 596 4609 865 50848 9685 3643 58527 PMC6283264__F7 The TLR pathway and let-7e target mRNAs 7096 7097 10333 7099 929 114609 4615 54472 841 54106 7189 51135 7187 23118 10454 29110 5465 3663 3665 3661 3553 4843 4513 941 942 958 8772 3654 PMC6284331__F1 Effect of changes in ECM‐mediated signalling pathways 6714 4921 6010 960 85451 PMC6284860__F1 p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1 613 4067 29760 5728 695 5336 2549 6850 27086 933 4602 4609 930 PMC6288292__F2 Effect of different preconditioning stimuli in the MSCs response 3082 2668 9242 7039 7852 3553 PMC6288349__F7 Signaling in HIV-1-mediated inflammation 3107 3553 1234 7852 920 114548 PMC6289210__F1 MALAT1 in cancer pathways.Notes: MALAT1 promotes generation of the six phenotypes of cancer 378938 581 6850 999 1000 1994 114548 22943 1499 3569 109136578 2305 PMC6291014__F1 Signaling pathways linking EphA and RhoA in regulation of cell adhesion/repulsion 6714 5058 387 6010 998 PMC6292558__F2 Bioinformatic analysis of differentially expressed proteins (DEPs) identified in this study 7070 5873 7057 2026 7114 1917 2922 5799 7078 5126 389434 4023 6513 7058 4133 7253 3315 728378 54332 6678 7038 57016 6622 5346 7076 10135 796 7430 948 6447 2673 5979 5179 2191 5493 23336 1363 3490 4017 1113 3880 4318 2167 1462 2335 3371 9201 7857 493856 10631 7448 10381 5908 4312 4313 4314 1101 3918 4319 4317 1301 1311 5649 10319 4322 4320 1302 6696 1280 1281 284217 7148 1282 7059 9313 3909 7060 4316 1284 4323 1286 56547 4324 7143 4325 3912 4326 3913 7450 10893 7077 3914 4321 7079 6853 1956 6854 3316 6844 23025 5594 4893 673 10814 3845 5894 22999 22808 4342 6761 6809 3248 7425 947 1644 1114 5864 63923 5566 53407 6762 PMC6292965__F9 DT-13 promoted mitochondrial apoptosis and inhibited metastasis via suppressing PI3K/Akt pathway 5163 572 581 842 836 PMC6294171__F2 Canonical and non-canonical inflammasome signaling pathways.Notes: The figure describes both the canonical and non-canonical signaling pathways involved in the activation of different inflammasome components including NLRP1, NLRP3, NLRC4, and AIM2 58484 9447 114548 22861 834 79792 3553 PMC6295143__F2 TREM2 molecular signaling in microglia, initiating phagocytosis and microglial survival or modulating proinflammatory response, is not well characterized so only validated components are displayed 54209 7099 6850 PMC6295338__F3 TPS EGF Response Pathway Model 1950 6311 868 9774 29924 9590 1956 10040 9146 5604 57674 5566 476 10006 5595 5747 861 5594 1457 26469 55824 3636 23607 5058 9732 10252 2077 5635 8471 2885 8874 867 4261 147179 7846 1969 6464 5601 5335 2268 8976 1399 60 5786 25828 PMC6296478__F1 Post-transcriptional regulation of cytokine expression and signaling 4615 54472 51295 7189 23118 10454 6789 9021 864 861 6667 8743 PMC6299112__F2 Overview of the canonical miRNA pathway, from synthesis to degradation 29102 54487 4343 22803 PMC6299112__F3 Neuronal signaling events that influence miRNA biogenesis, activity, and degradation 627 29102 1714 107966124 4343 27161 22803 PMC6299112__F4 Proposed roles for miR-137 at the glutamatergic synapse 10815 6857 4905 8224 627 5728 57534 5163 2932 208 2475 253260 3084 PMC6299275__F3 Canonical pathway analysis using MetaCore identified EGFR, PDGFR, and mTOR signalling as the top 3 canonical pathways modulated in FCD type II patients 1950 7099 2690 1956 185 5763 7189 5170 9261 23770 64798 2475 9894 9675 PMC6299398__F2 Affected pathways in SHH-activated medulloblastoma 7157 5727 6608 8454 51684 2735 2737 2736 9978 6500 1778 PMC6304355__F5 Distribution of target proteins of SBD on the compressed ‘NSCLC-pathway.’ Four pathways form the tubular NSCLC pathway 1950 1956 998 6774 7124 3550 545 4193 4513 836 842 150365 581 PMC6304934__F7 FSIP1 regulates autophagy in breast cancer 161835 9776 8408 324 1499 7249 7248 2475 PMC6309361__F2 Effects of hemolysis on the monocyte/macrophage compartment 998 81704 571 121599 PMC6311083__F4 Qualitative Biological Regulatory Network (BRN) of Hexosamine Biosynthetic Pathway (HBP) intersection with PI3K-mTOR-Myc signaling and P53-MDM2 signalling axis 2305 8473 10724 4193 PMC6311798__F1 Red arrowhead represents inhibition 4089 4088 4485 5728 3479 5163 5164 3630 3643 PMC6315117__F4 Pathway analysis graph of G1/S checkpoint 55003 545 4193 4089 4088 4149 993 25942 6839 472 648 25 PMC6315659__F2 Regulation of the Hippo/YAP signaling pathway in malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) 1950 1956 4771 4485 9113 26524 60485 PMC6315991__F1 Links between Lipid and Iron Metabolic Pathways 6309 10682 50814 7108 57817 95 3156 31 47 57678 2242 3931 4015 9843 55240 8031 5093 6101 PMC6317740__F1 Dishevelled: a masterful conductor of complex Wnt signals 4040 4041 1499 6010 998 PMC6320606__F3 Schematic model depicting the proposed signaling pathway in LH/hCG-induced the resumption of meiosis 2492 4880 9210 2661 1950 4882 1956 1311 4661 7465 PMC6322364__F7 TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress 545 983 5111 246243 7072 2177 672 PMC6326181__F7 Integrative Modeling of Cancer-Type-Specific Hippo Regulatory Networks 10413 7003 8463 7004 7005 9344 51347 57551 9113 55233 26524 92597 4771 6788 6789 23286 122786 60485 1029 546 23152 1956 4613 3480 3417 472 324 4089 4170 2064 22807 54894 5728 3845 5925 8289 7764 6657 7157 PMC6326667__F5 Environmental enrichment largely prevented age-SNCA-dependent disturbances and activated topologically relevant genes in the SNCA interactome with respect to both disturbance modes 7038 57128 4706 51103 5224 95 51079 6602 1137 3028 710 84465 1271 4712 57580 4700 219699 928 4925 156 633 27089 3754 84446 712 721 11315 6571 8625 3691 22895 4323 208 684 397 28996 6622 4616 1958 57470 4128 2934 2670 7431 10461 5894 7347 28985 199 472 4929 10397 6256 80781 4862 4638 29760 6678 894 8553 8863 9343 1520 3399 1633 3096 25777 2905 1514 7178 2207 26227 1408 8864 79365 836 3689 1407 5176 3646 3708 3630 3956 713 23152 8099 23373 PMC6328617__F4 CD44v6 engages in colorectal cancer progression 960 2549 4193 9817 3162 2495 1728 PMC6328866__F3 Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma 6241 55388 55635 29125 201305 9837 80342 326624 59348 339390 6491 4629 10926 51514 55143 7913 7884 10635 221150 10021 610 4605 6168 9928 10660 11130 54443 79733 257240 84930 9787 83540 5730 151230 701 11004 56992 220134 84891 991 55789 57524 9493 9833 9319 81610 5111 84460 55872 90226 91392 7272 7965 367 1395 1235 6343 10721 4880 7411 3097 2597 6595 7173 6628 1815 678 285601 11010 7402 2788 10457 2444 11123 705 3344 11278 92304 147138 10135 4236 5832 23355 2208 5464 85453 51184 401 3939 5223 6675 158 202309 29088 26289 57659 7704 84275 53 100131187 3028 56995 55552 4085 8911 376940 PMC6330595__F1 Graphical representation of glutamine/2-HG pathway and therapeutics options in renal cancer based on Shelar et al 3417 3418 728294 79944 7403 PMC6332659__F3 Tissue-specific gene regulatory network of the top KDs in psoriasis 2549 867 1956 2885 1147 5966 572 4791 4170 3932 4792 4067 60 7128 7076 3587 4609 26354 1212 1520 29087 54205 7431 718 3134 3133 972 3105 10320 3123 585 8743 4904 3600 83693 5641 6362 6404 8764 6892 7185 1436 975 3135 80301 5720 3606 5552 355 3107 929 962 3001 1536 330 1512 3119 916 919 3553 8718 7535 9524 2149 4050 923 939 717 7422 8717 28755 5707 945 11031 914 3603 128486 10437 729 PMC6334985__F7 Retinal phosphoproteome 5947 3915 3913 1356 133584 339302 23418 6094 6010 5791 3000 2551 112724 7275 1121 6102 6000 10763 26059 25794 5015 23746 4209 7507 1398 348 5961 24 54714 6007 847 8754 2779 2782 57605 3064 5147 8213 2103 718 6247 7399 57010 4308 2792 4724 6101 4942 145226 1406 128408 10243 5792 9094 2973 367 4628 26121 5925 2879 583 PMC6335102__F7 ANG II signaling and vascular fibrosis 1956 1839 6868 367 4087 4088 383 PMC6336830__F3 Summary of the mechanisms involved in the stimulation of brown adipogenesis, mitochondrial biogenesis and energy expenditure by some dietary molecules 7442 79054 155 1312 5465 63976 7350 PMC6337329__F6 Proposed model of molecular interactions and clustering analysis 2475 55742 3611 6251 387 998 6093 PMC6340995__F7 SNO profile of cell death network in Chagas disease (ChD) 2243 2316 301 7528 7414 3329 7170 7057 4860 5691 9588 1431 2934 2950 136319 3043 PMC6342007__F2 Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases 11035 29110 8737 8717 8772 57162 10133 257397 23118 9825 1540 PMC6343200__F5 Current Strategies for Elimination of HIV-1 Latent Reservoirs Using Chemical Compounds Targeting Host and Viral Factors 920 5970 56257 1025 23476 2146 6839 6667 26013 56950 51574 10919 PMC6347283__F2 Effectors downstream of MTORC1 10891 5468 468 790 10797 29904 27250 1975 6194 596 4170 1938 1977 1386 23409 5091 440 26227 2746 2744 3091 6774 4609 7528 PMC6347501__F3 ‘Stemness’ maintenance pathways in CSCs 4040 4041 9429 6608 2932 2735 324 3091 1499 3939 5163 5165 5164 7008 PMC6348202__F2 Proteomic and Functional Analysis Reveals an Increased Chk1 Activity in Lung Cells that Contributes to Cisplatin Resistance(A) Identification of genes involved in differential cisplatin response 7173 50616 867 1950 6010 5728 545 472 PMC6348405__F6 Cooperative gene regulation for mitochondrial quality control by Nrf2 and ATF4 57761 440 6472 29968 10797 468 7296 65018 PMC6356072__F4 Protein-protein interaction networks among differentially expressed proteins 103 124454 55157 56901 2762 729956 23557 55699 6582 8504 219402 2628 8425 10645 10056 10157 11031 157869 83451 114902 170954 27247 18 4924 80155 79672 84908 23474 6059 1374 10531 26266 2677 1891 22 34 4329 35 8669 4836 4976 8801 4712 152002 4726 8665 1737 3646 6573 4942 4723 4729 10449 6139 83543 27163 9927 4716 6154 210 91408 9444 171425 2108 205 2192 2271 50 55847 4900 100272147 176 5802 5213 2286 7419 26060 6540 8895 57129 54205 51062 292 80700 291 10423 10630 80781 1282 9601 3958 55968 4128 213 9716 10529 4763 23450 2934 2244 1 8404 4811 55234 3912 3910 1464 81 2266 3306 9529 2535 6627 3265 350 2243 28988 2781 832 90411 388 56252 1803 60 10097 7175 80331 22824 79443 8815 11346 6742 51499 126298 10694 9898 1471 26355 55326 29929 79068 4008 10092 1778 283742 3954 26136 6515 8655 113829 84303 3054 85456 9040 55740 80173 178 51399 65059 2202 10614 23028 2635 84299 51474 55915 55275 64710 5764 PMC6357151__F5 Differential Transcriptome Responses to Aflatoxin B1 in the Cecal Tonsil of Susceptible and Resistant Turkeys 116 2695 4828 2922 2696 1129 7432 2925 886 6750 6755 51083 5697 4887 9340 885 PMC6358305__F2 Incorporation of arachidonic acid into membrane-bound phospholipids by the Lands pathway () 4513 4512 717 4015 26136 38 39 8694 84649 PMC6361956__F5 Cerebellum (CB)-specific biological processes in Alzheimer’s disease (AD) brain 258010 5121 4974 4135 7415 8721 961 3029 7086 5954 51031 7414 388 10204 1312 348 4155 8724 8976 2790 4685 351 593 127833 2778 7070 832 2319 35 1975 6620 1311 4756 4827 4710 23092 4519 4692 PMC6362586__F4 Associative gene network describing interactions between three central genes/proteins of the extrinsic apoptotic signaling pathway biological process 7185 367 2534 80196 5728 672 9531 435 2029 56616 4803 7040 4170 596 356 6591 2019 7078 355 3574 64374 652 3958 7124 PMC6363022__F1 Summary of interactions between ECM remodelling and kinase activity 4015 960 4921 5159 6714 6010 6774 7048 1956 7046 1950 5654 PMC6363035__F3 Schematic Representation of DDR1-collagen signaling pathway in cancer 4071 6714 6194 3280 6774 4513 1000 PMC6363635__F1 Pathways to DHT synthesis (modified from Ref 6715 1646 8630 5959 10170 8608 8644 3292 1586 3294 3293 PMC6369349__F1 Molecular signaling pathway of TNFR2 7124 8772 7185 8717 7186 7187 23118 257397 10454 PMC6370010__F3 Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain 5879 1020 5924 5058 3984 PMC6370048__F2 Downstream effectors and upstream regulatory pathways of RKIP 6774 673 1000 7528 5728 4851 2146 2932 571 156 1499 8091 3383 4312 7412 7852 PMC6370335__F2 Intercellular and intracellular signals that initiate liver regeneration 8309 3553 3082 1839 1950 7039 6774 PMC6371191__F5 Role of PAK signaling in response to inflammation, altered microbiota and hyperglycemia 7099 5058 2932 324 1499 5970 3725 PMC6375072__F1 Molecular signaling mechanisms of nicotine mediated anti-inflammatory effects 3717 6774 3146 PMC6376270__F5 Interleukin‐1B (IL‐1B) was up‐regulated in nerve regeneration 8792 929 5743 958 638 4616 2920 3932 27040 472 29760 695 613 6850 4067 331 8717 7706 3553 3929 114609 4513 4615 7099 1950 4803 5805 4049 4050 114034 PMC6377309__F2 SAMHD1 prevents the activation of NFKB signaling 7124 5971 25939 3659 PMC6378226__F1 Cell death pathways currently implicated in motor neuron cell death in ALS and related miRNAs 355 8772 841 197259 836 842 581 PMC6380503__F1 Metabolites as regulators of insulin sensitivity and metabolism 7099 10454 4615 3667 3661 5091 PMC6381758__F7 Modified KEGG map of the JNK and p38 MAP kinase signaling pathway showing transcriptional changes 7040 7042 356 7124 7043 7132 7046 7048 355 8717 7186 1616 11184 4217 5494 6416 5609 5608 5606 1843 1847 1846 1848 3305 3306 3312 1845 84867 5801 5778 9261 994 7867 9252 8986 4772 3725 2005 1649 4208 1386 4149 4775 2002 3315 7157 9448 8491 4214 4296 PMC6382076__F1 Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells 3454 7099 3455 3654 3656 7189 51135 7187 10010 6773 6772 29110 10379 3661 7124 7048 4089 5970 3394 2634 3433 3437 10581 10410 4600 8638 6347 4502 4609 1437 467 4318 8772 8717 3135 3105 7045 7157 2167 7205 64127 7867 4118 4615 7297 3716 PMC6386537__F3 Immunologic Pathways in Protective versus Maladaptive Host Responses 7124 2920 2921 6370 3624 3625 83729 5008 3791 1233 3977 1236 3976 6366 1950 1271 268 2833 729230 2323 4049 4055 650 4050 1230 356 3952 7536 59067 29949 6846 11009 1896 2689 10913 2690 5617 149233 3606 7173 4352 55801 627 4351 5447 2002 2353 2885 4342 2316 3725 1537 7186 2645 355 1616 4149 929 23118 257397 7189 3563 3558 6347 1270 56832 85480 7216 1610 10487 4609 51295 51701 PMC6391339__F1 Biogenesis of miRNAs 54487 29102 5901 26523 1977 1233 167227 PMC6393772__F2 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways 27035 5170 6010 124056 3984 PMC6393772__F7 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways 6649 6714 2932 673 1499 PMC6399501__F3 Disorders resulting from mutational defects in the lysosomal SL degradation pathway 2720 3073 3074 2760 2717 2581 2629 6609 427 410 5660 PMC6400837__F1 Notch pathway promotes drug resistance by regulating cancer cell survival, glycolytic switch and cancer stem cells 596 226 5164 3099 4363 3939 4609 182 5213 2023 3714 3479 28514 3280 6774 100188776 3073 54567 3516 PMC6402958__F7 Models of TGFB superfamily signaling and Harmine-TGFB superfamily actions on human beta cell proliferation 10220 1859 4087 4088 4091 4089 4092 993 2305 983 1017 7403 4609 1869 5929 4221 1870 PMC6404322__F1 Challenges of driving CD30-directed CAR-T cells to the clinic 6361 1233 6367 PMC6405305__F1 Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition 7046 7048 2885 571 6935 4609 999 1000 8091 PMC6406849__F3 LRRFIP1/GCF2 binds to exogenous and endogenous nucleic acids and activates type 1 interferon and pro-inflammatory cytokine responses 9208 4615 1499 3661 PMC6407245__F1 Nongenomic and Genomic actions of Thyroid hormone and thyroid hormone receptor 6714 7068 6774 7067 2475 9611 10873 PMC6407289__F11 Model for Pyk2 action in AD risk 28 5662 2534 387 9475 PMC6409969__F7 Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21WAF1/CIP1 and p27KIP1 in Cancer Cells 9212 995 983 581 4193 PMC6410037__F2 Telomere length maintenance mechanisms 7015 7012 100134934 80169 79991 5893 5888 10714 5111 PMC6411824__F1 Overview of the Nrf2 pathway activation 5881 9817 6256 100420631 9978 8452 4094 PMC6412382__F1 Mammalian target of rapamycin (mTOR) regulatory network 3630 7132 8140 2885 2887 3551 5563 6198 3667 153129 7249 7248 51256 5163 5290 96459 5728 6009 201163 1147 10670 10325 64121 58528 64798 64223 351 84335 253260 2475 51513 4553 652968 9675 6446 29984 112476 1978 8408 23175 6249 6194 1977 1975 PMC6423516__F3 Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss 9575 1407 8864 6794 8408 23411 5225 23410 23409 23408 65018 7942 4485 1385 8087 7157 4286 7030 PMC6425566__F3 Mitonuclear communication 6023 142 2926 23411 1958 2056 PMC6425710__F1 Pericytes contribute in homeostasis of the BBB through different mechanisms 4089 1000 54567 4854 7075 2260 6714 3091 5159 50507 4803 PMC6425710__F2 Under pathologic circumstances, pericytes present stemness or trans-differentiation potential 6657 4133 2670 10215 5159 960 947 7412 1003 PMC6425834__F2 Models for potential interaction between Toll-like receptor 4 (TLR4) and protease-activated receptor 2 (PAR2).(A) Direct interaction at the plasma membrane model 7099 929 3661 4615 7189 7187 29110 PMC6428271__F5 Comparative proteomic study reveals the enhanced immune response with the blockade of interleukin 10 with anti-IL-10 and anti-IL-10 receptor antibodies in human U937 cells 355 7124 29110 8772 8717 1616 7186 331 56616 27429 54205 1676 4000 1677 3984 6709 2620 397 3611 5163 11140 4170 572 4193 6009 79923 2475 1977 22985 PMC6429193__F1 JAK2-STAT5-SOCS pathway and domain structure of STAT5 2056 6714 3717 5062 5058 8473 2475 10724 1024 8161 3055 6010 PMC6429383__F7 Compound-target network of 3DC2ME 7442 5914 3039 4791 5465 6608 6557 5468 1636 2798 2322 5142 2263 5602 2555 3791 154 1910 1815 1132 3690 786 4792 6870 782 1950 10988 54205 1719 283383 55799 2568 1520 5467 785 5644 5915 5443 351 2235 213 6095 6462 3815 783 5347 3501 7422 847 10499 81027 32 1432 5578 4069 2159 6714 5742 6256 2104 1513 2778 11251 596 784 5916 5447 3503 4843 6122 779 5579 5972 3269 2100 1080 3932 8913 1135 5243 773 5743 2172 1066 3040 1559 5328 4311 7054 PMC6433789__F3 P53-HSF1-PGC1A integrated responses in HD 6874 3064 6742 3297 55294 10202 4193 PMC6433939__F1 Schematic diagram shows the regulatory non-coding RNAs in NAFLD disease development and progression 100124700 1316 5728 55384 100316868 59 100505854 4547 283120 8864 4087 5465 5355 3172 PMC6434238__F2 Network for abnormal sub-pathway 6654 3845 9020 894 7993 1027 29931 5934 2309 595 5820 10000 2932 5527 8847 5728 2998 84809 64595 5534 4659 5530 5502 163688 815 5501 2903 8629 56252 6195 2263 2247 7869 2885 3728 5914 3480 23533 1017 5925 1869 5296 10991 4089 PMC6435658__F7 Illustration summarizes the molecular mechanism and signaling pathways underlying the effect of Dis on HCT-116 cells 7124 355 8772 29072 3065 10014 3066 581 3397 3398 PMC6437556__F1 Vitamin D metabolism and signaling 1593 1594 2638 7421 1591 387 6010 1026 999 22943 27121 2305 4040 471 PMC6437992__F1 ABT cell receptor (TCR) signaling pathway 324 920 27040 3932 5335 399 7535 2885 6654 7409 10125 387357 5311 5312 9840 80342 PMC6438423__F4 Analysis of the PI3K/AKT signaling pathway based on the KEGG database 11140 5106 5934 3164 5894 208 4193 4170 5604 5728 2475 7529 7249 6194 1975 5163 595 4609 PMC6441621__F1 miR-223 regulates the canonical NFKB pathway and other pathways related to cancer 5921 5316 10725 4615 3654 51135 7189 10454 6772 3925 3480 8454 2308 114548 4208 6776 6774 9935 5966 PMC6442448__F2 Target-pathway network 4312 5467 5468 890 5465 6256 5733 3356 2891 2932 154 1956 3643 5139 3586 7157 1129 5054 4846 5294 7422 5970 3458 4843 150 3791 7124 2475 6347 3320 836 5743 4318 5742 5328 959 6401 4314 653361 PMC6442489__F7 Schematic illustration of SAA attenuating kidney oxidative stress in 5/6Nx rats 9817 847 3383 50507 PMC6442705__F7 Mechanistic illustration of the effect of alcohol on the dysregulation of genes involving several metabolic pathways leading to alterations in serum metabolomic profiles 644 6783 6822 26291 1581 1582 3172 4143 1593 4548 4524 635 9420 875 1491 25801 51380 8213 9965 PMC6444160__F6 Networks of Ingenuity Canonical Pathways results of mRNA of APP/PS1 and SAMP8 mice brain tissues 23242 29119 253152 10468 79682 1869 1058 144501 3595 963 4023 960 858 1871 116372 3983 5914 114569 144203 7629 5764 5179 7161 4982 6279 7057 5915 51655 7054 5979 6696 126626 56137 23224 5649 85358 10579 221037 4661 56475 2258 3736 10769 2016 84034 3663 5801 83468 158471 54913 993 3214 3216 3218 3215 91653 9960 3217 1789 PMC6445055__F6 Gene networks and canonical pathways generated by Ingenuity Pathway Analysis 1356 51154 7428 9789 2146 114569 4736 100124700 3431 6156 7419 PMC6445872__F2 In monocytes/macrophages and adipocytes, SIRT1 deacetylates NFKB(p65), resulting in reduced expression of inflammatory mediators such as TNFA and MCP-1 2475 23411 3667 759 PMC6446225__F1 Proposed overview of the vascular immunopathology of sickle cell disease (SCD) 948 7035 301 7097 2357 2358 7099 PMC6448793__F3 Ciliary signaling systems within tumors 51684 2737 2736 6608 5727 596 2735 4609 3280 5156 4040 4041 387 1499 23002 5754 8313 23236 PMC6450927__F10 Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A 10628 114548 7099 4615 PMC6452163__F3 Classical neurotransmitters of clozapine neighborhood in A auto-layout format and B a gamut of multifunctional molecules identified by IPA core and functional analyses (see table 2) 59340 11255 2890 5021 3952 3355 7422 7349 4922 1392 434 2907 181 7200 PMC6452569__F8 Parturition-specific signaling networks constructed using shortest paths and differential expression data 5241 5613 6256 7186 3275 836 5594 5970 367 5914 5008 55509 4609 32 51226 1973 8870 6648 3708 1050 10135 4502 64005 5764 8877 4860 4489 5329 51619 3033 5209 5292 947 57659 5601 5566 1601 3265 7534 5908 5747 4651 5037 7428 4802 8030 55827 1429 79026 5217 7421 6714 572 2033 2810 4193 415116 9775 290 PMC6456212__F8 A carnosine analog with therapeutic potentials in the treatment of disorders related to oxidative stress 6648 847 23410 4513 PMC6462412__F2 DNA repair pathways—a toolkit for viral replication 672 9156 641 1763 7518 3981 675 5888 79728 2177 348654 84464 80198 146956 545 PMC6462501__F2 Signaling network of the MSC components related to protein synthesis and cancer 355 1616 1019 2475 7422 7186 64750 545 472 PMC6462501__F5 Systematic association of the MSC components with mTOR and DNA repair pathways 7132 3643 5295 8503 472 3551 2885 5563 10000 5894 2932 5594 64083 7965 2475 6009 529 9296 58528 5371 9255 6446 1981 1974 25 6117 6118 6119 545 7157 5888 1653 7517 PMC6463300__F1 HGF/MET signaling pathway 3082 6420 2549 2885 1398 5879 6010 PMC6466304__F2 Diagram of major H4K20-related proteins and their proposed role in DNA double stranded break (DSB) repair 51111 387893 2177 23133 5253 84787 7468 9656 9025 165918 PMC6468297__F3 MDM2’s switch from a negative to a positive regulator of p53 following DNA damage is dependent on the p53 mRNA 4193 472 6125 6135 PMC6468621__F3 Lung adenocarcinoma treatment and emerging therapeutic potential of targeting macrophages 6387 6347 8685 8205 PMC6470739__F2 Antioxidant signaling pathway regulated by quercetin 847 581 9817 1958 4094 PMC6470985__F3 Regulation of the mucus production by MAPK signalling 7039 1956 4615 6714 3727 6667 3170 4585 PMC6471725__F6 Cinobufagin-induced effects on hepatocellular carcinoma Huh-7 cells with mutant p53 983 5111 891 6790 3190 581 PMC6473131__F1 Possible mechanisms of cancers caused by Porphyromonas gingivalis 9021 3716 6774 4321 4312 3553 PMC6475670__F5 Tumor necrosis factorA signaling in gastric cancer 7124 8717 7185 8772 7186 PMC6477778__F1 Proposed sources of NOD1 activation and corresponding physiologic, endocrine, and cell tissue communication events leading to insulin resistance in different tissues 10392 8767 5091 PMC6477784__F1 The inflammasome as a gear or cogwheel that couples purinergic signaling with the complement cascade (ComC) in the process of HSPC mobilization 847 3146 3553 PMC6478618__F2 Nonalcoholic fatty liver disease-Kyoto Encyclopedia of Genes and Genomes pathway and mechanisms of disease pathogenesis 9021 3667 3630 3643 3952 10682 619501 7494 5879 64718 7186 83737 468 581 637 PMC6480119__F9 Schematic diagram of EGCG anti-tumor mechanisms based on reverse docking 51135 3656 3654 7124 7465 1022 6416 3845 1017 25 4217 4915 4914 317 3551 207 5292 10039 6850 613 10769 1263 5588 4843 699 3718 208 PMC6480472__F1 Diagram of microRNAs and their involved pathways to cancer hallmarks 574467 6098 1956 2885 355 2475 1493 941 5728 6774 406974 1163 9839 6935 3939 3068 442917 4193 100302132 PMC64811__F2 Failure of endogenous regulation of wound-healing in idiopathic pulmonary fibrosis (IPF) 5228 4513 5640 PMC6483058__F4 Visualization of resulting networks from Min-cut on the pathway of AD 351 836 4842 10313 57142 3028 7384 8883 3416 5534 4035 824 5331 808 637 823 842 6868 7124 3710 5595 22926 4512 317 840 2776 23236 8772 355 5330 2902 2906 572 6622 348 163688 4023 4137 801 5530 322 54205 2932 23621 8851 2597 9451 9377 841 5664 1020 7132 23385 2081 54623 2904 3708 PMC6483058__F5 Illustration for cut-edges and the CTGs in AD pathway from KEGG 351 322 54205 842 317 348 4035 5664 6622 5663 355 637 8772 840 22926 9451 823 8851 1020 2597 2932 2081 PMC6487669__F16 De Novo Pyrimidine Biosynthetic Pathway Diagram 790 1723 7372 129607 56474 PMC6491842__F4 Enriched genes from the ANOVA statistically significant disease status gene list (p-value < 0.05) found in the KEGG Alzheimer's disease pathway (hsa05010) [Kanehisa and Goto, ; Kanehisa et al., , ] 10020 351 1379 130749 23385 3416 4023 572 836 8772 637 6622 6259 22926 7124 2932 842 317 PMC6492270__F1 In response to injury, there are significant and dynamic changes to the OGlcNAc sub-proteome 7494 10724 8473 2932 2539 6667 PMC6492897__F2 Ingenuity pathways analysis (IPA) of ASS234 (5 μM) treatment 85451 9817 3725 571 4094 468 7415 9097 7314 847 10963 2877 9709 10574 7295 8192 2936 2052 2729 5479 2730 10961 873 PMC6496459__F2 Cellular metabolism networks 2194 3939 51660 5166 5163 5165 5164 717 718 PMC6496801__F2 Multiple pathways that mediate pyroptosis 8772 79184 91662 140609 114548 7189 10628 4615 9447 79792 7099 387 3665 7297 10379 PMC6498733__F1 Beta-adrenergic signaling pathway in prostatic cancer 572 10298 387 3066 596 2026 157 PMC6499694__F7 Working model of how the spatial distribution of nuclear DNA damage and extracellular neurotrophic factor signaling coordinates AKT-mTORC1 activation 4803 5163 23239 6009 472 51567 7155 PMC6500618__F7 A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis 4170 4846 3725 7124 51561 5970 1432 836 5294 5321 PMC6505497__F4 Sprouty2—a Novel Therapeutic Target in the Nervous System? 5894 7016 1859 6714 10818 2885 6478 PMC6505517__F4 Interaction mapping of overlapping proteome changes in astrocytes treated with GBM a -stem and b -diff EVs 23521 4134 6218 10644 3921 3032 10128 5660 4613 2335 353 7001 7157 7514 9588 26135 10989 4609 6950 2316 6230 5052 351 7531 121457 2521 253260 7040 3845 6500 11315 6520 8974 7415 4780 5631 3998 811 3295 10961 84823 406906 3703 3848 3858 11333 11171 1956 5053 7170 1500 4924 10093 2064 7168 1073 6836 4942 6134 5704 8572 4478 5976 9343 800 1508 1021 1019 87 372 5202 2632 10398 6888 1340 4830 5034 PMC6506535__F4 Role of macrophage, fibroblast and endothelial cell pathways in MAIT cells 7124 4055 23765 84818 8651 3717 9021 5970 6774 3383 4615 PMC6508100__F2 MCD genes and cytoskeletal regulatory pathways 1020 1600 81565 4133 4131 1641 6010 3796 3800 2009 9693 7436 PMC6509750__F3 Influence of TGFB1 on the balance between the canonical WNT/Beta-catenin signaling and PPARG 22943 4040 4041 5728 324 1499 PMC6513836__F7 Brief summary of the possible mechanisms of KSHV-mediated pathogenesis at the cellular level 355 4086 1021 3586 3569 3606 182 3280 23462 4851 5548 PMC6514096__F4 Interconnection of the pathways studied, the genes in which we have measured expression and connection to mitochondrial respiration 23410 6648 5728 1977 2475 23411 65018 9927 3091 7351 100 PMC6514310__F2 Upstream and downstream of mTORC1 and mTORC2 5728 81929 6396 54468 9681 8131 10641 7248 7249 51256 153129 790 6009 10797 23334 84219 8408 PMC6514318__F1 Molecular genetic pathways in long-term epilepsy-associated tumors (LEATs) and pediatric type diffuse low-grade glioma (DLGG) 2260 3667 5728 5163 4763 673 64798 7249 7248 6009 6446 2002 6722 9776 8408 60673 1975 1977 PMC6518697__F6 Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease 3371 222663 3955 5156 23493 51705 7422 6774 9021 4915 6690 9049 7092 284 4883 63827 4316 1356 6289 146754 1763 80206 27147 2146 285943 285958 10365 3965 1943 PMC6518927__F6 Network of genes targeted by miR-21, based on miRTarBase predictions and analysed by String 10252 81848 7145 867 10251 10253 27250 2885 5925 5728 1870 8434 2146 8772 4318 841 4092 57154 7046 64795 79018 317649 23191 PMC6518944__F4 Aberrant BCR signaling in GC‐derived B‐cell lymphomas 727 718 930 84329 613 6850 29760 695 3492 5728 6929 54106 407975 5163 84433 3399 4615 8915 3654 51135 10892 7189 7128 4794 4792 2475 8517 3551 973 974 PMC6520835__F3 Therapeutic targeting of oncogenic HH/GLI signaling in cancer cells resistant to SMOi 51684 6608 3569 1950 9149 2475 324 23432 3280 6774 3725 23476 PMC6523766__F2 Metabolic reprogramming in RCC 2539 2821 355 2597 5230 2271 3939 2744 6390 6510 PMC6524659__F2 Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets 8743 7124 91543 572 8717 7186 6041 6035 3716 3717 7297 83939 637 7706 7098 840 836 114548 5971 834 57506 842 3437 3433 10379 10616 581 7249 7248 6737 2475 3659 5371 6672 3627 6373 3429 9636 3665 103 4843 6773 51284 3661 2537 PMC6527808__F1 Molecular pathogenesis of Epstein-Barr virus-positive NK/T-cell lymphoma 4609 1654 51295 2309 57531 5796 PMC6533689__F2 Telomerase regulation and telomere elongation pathway 7012 6774 11201 7015 7011 PMC6537414__F6 Functional analyses of five core clusters 3561 3560 5618 3572 3566 2690 1441 3716 3717 5771 8027 5777 5781 5295 6774 2885 207 2033 8554 2475 3265 1154 2670 596 1026 598 4609 5894 4170 9021 5292 PMC6538740__F1 Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment 5447 5970 5300 1387 7421 6774 2475 3190 4904 7150 2335 1499 351 5925 367 10273 5894 203068 7726 7157 759 2547 1956 6714 4609 1147 11140 11200 3308 5591 7415 7153 10128 7514 1937 3791 545 409 4792 7428 2810 5371 7316 1432 1994 23411 5518 595 60 142 7529 3320 PMC6539482__F3 Interaction between TNFA and the Hippo signalling pathway 64112 7186 8717 4485 9113 581 PMC6540047__F3a Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices 8772 8737 7187 57506 10379 10010 2994 3661 1386 3458 3441 3442 3443 3440 9636 64782 29 473 338376 PMC6540604__F1 The deregulated metabolic pathways in AML 2167 355 948 8877 1786 54790 4170 2539 581 3939 1431 445 PMC6541264__F2 Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs 2908 3107 801 3725 3958 3106 6256 7514 7157 6714 154 10075 1080 1398 4914 409 5591 7186 10987 2547 8453 648 7532 6464 4163 408 3326 6780 5684 3308 8945 5111 7415 808 2033 7529 23291 3676 3315 4734 6790 2885 7874 5566 6774 9657 2316 4691 805 7520 857 5970 2521 2353 2597 6134 4087 4171 5595 9641 1017 57154 351 203068 51547 1956 7132 7534 7428 7531 1386 2335 3065 5518 1213 6045 60 1432 10856 1387 7013 4869 10399 7412 8726 6657 23363 1499 1460 7316 672 7431 7374 5315 4214 8517 83987 25 4088 PMC6547588__F1 Spatial regulation of non-amyloidogenic and amyloidogenic processing of APP 5663 102 23621 23163 382 351 9784 8301 23607 5664 26088 274 6844 9341 PMC6548290__F1 MAPK and MST2/Hippo signaling, energy and glucose metabolism 2023 369 283455 PMC6548759__F3 Results of Pancancer Pathway Panel analysis 25805 4089 3458 9978 8454 6500 4052 1874 7046 6667 387 10468 5308 4838 7057 PMC6551999__F5 A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? 1537 595 6774 PMC6553502__F2 Parallel Molecular Evolution in Pathways, Genes, and Sites in High-Elevation Hummingbirds Revealed by Comparative Transcriptomics 5162 4190 6389 4716 4535 4728 4710 4512 27089 51382 2109 7381 PMC6556902__F1 Examples of representations for contextualizing disease associated genes 59344 5406 4688 2876 2877 2879 3109 3055 9392 29108 22806 695 4056 328 3295 PMC6556902__F3 Significant pathways identified using Tied Diffusion through Interacting Events method, an approach that can extract the most likely set of interconnectors between two sets of nodes 4319 7078 4852 4318 3115 1080 8914 3135 2068 3119 154 7422 6356 11127 10111 1906 23607 6347 108 1786 7040 142 817 5144 847 3123 3383 8651 3452 7124 3444 6647 22806 3443 3718 5142 4843 929 3458 596 5008 7297 30009 3460 59067 59307 4615 5515 11213 5618 4791 3596 3559 11141 2688 3592 9180 3606 3654 1443 54472 4352 50615 3590 5617 841 84174 51561 3558 3977 1439 3574 3554 3552 8809 3586 3562 50604 8808 1440 3600 8807 149233 7066 3603 3578 1437 834 7850 282617 90865 3557 3556 3572 11009 PMC6558796__F3 Gene network analysis of RNA-Seq data from MDA-MB-231 and OVCAR3 cells 54625 24138 3437 3434 3433 6773 4599 3660 7297 3716 3717 161742 4940 54739 9473 11235 286 54892 10051 23397 55635 23424 324 259266 55143 51203 6502 10112 348235 595 51659 5111 9883 100101267 91543 1164 PMC6562791__F1 Interconnected pathways of non-essential amino acids (NEAA) metabolism 5053 2744 440 445 435 100653366 586 6472 6470 5625 29968 26227 5723 PMC6562905__F2 Role for fibroblast-derived metabolites in tumor-stroma interactions 3945 2752 64782 PMC6565468__F1 Convergence of Developmental Origins and Oncogenic Pathways in Malignant Brain Tumors 324 5091 3082 1950 1956 4763 3418 3417 2475 1021 1019 4193 10215 80312 54790 1017 983 4613 PMC6565995__F2 Gene coexpression network for trans-1,4-polyisoprene biosynthesis involving mevalonate and methylerythritol phosphate pathways in Eucommia ulmoides Oliver 38 39 3157 3158 3156 4598 4597 2224 PMC6566851__F8 Crosstalk of signaling pathways under butyrate influence 6774 5879 355 4881 581 PMC6566886__F3 Leptin-induced signaling pathway 3667 3717 2932 2885 6774 6935 4513 9112 847 9941 595 9049 PMC6567807__F1 Curcumin modulates cancer progression by controlling diverse signal transduction pathways 6774 2932 637 1499 331 2475 572 581 85451 PMC6570467__F6 Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining 5409 10135 4507 2539 10380 5236 5230 10549 3422 7358 2947 2180 3939 9415 5033 2673 PMC6571165__F1 Signaling pathways that modulate cardioprotection in CMs 3491 4485 387 581 60485 163732 5728 6722 PMC6580171__F4 Human intermuscular adipose tissue (IMAT) revealed a downregulation of key pathways associated with insulin resistance 1154 8651 8027 596 4170 5771 51588 1437 5292 598 6772 894 3718 1271 4609 1270 316 10379 2273 1387 1950 2670 5781 6654 3265 5894 2885 5293 2475 207 4519 8190 1537 6389 479 4536 4535 4719 4720 4729 4537 4538 4541 55967 4705 51079 4694 4706 4707 4708 6391 4512 1349 10063 PMC6580952__F1 Salient features of EBV latent transcripts during B-cell transformation, followed by B-cell lymphoma development 958 5079 596 8717 545 613 4193 1869 1876 5292 995 604 3662 64422 9474 10533 894 595 1021 1017 407006 PMC6581552__F2 Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets 2264 5465 1582 9420 1593 26291 9965 1734 PMC6584619__F8 mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGFB1––induced collagen biosynthesis 468 4088 6472 5723 29968 26227 PMC6585737__F1 Receptors and signaling pathways mainly contributing to anti‐inflammatory polarization of microglia 50507 6774 6955 3566 8651 9021 4803 558 PMC6590191__F3 Interaction network formed by the encoded proteins of genes showing P values of potential relevance in our study (P < 1 × 10−4), according to the presence/absence of carotid plaques 115098 123624 121256 30010 221079 1889 26751 166336 130940 6695 57576 57512 6196 3801 11086 132204 51390 51059 7287 58495 27131 1826 7007 5578 142891 84570 52 2047 8398 10392 10257 4117 1289 9697 56776 2515 9922 9508 29933 257062 7005 682 81853 221078 80115 3993 PMC6591730__F3 Causes and Consequences of Enzyme-Induced Cytosine Deamination 545 5423 7374 4436 2956 9156 353497 PMC6594147__F1 Dysregulated immune response in the primary mediastinal B‐cell lymphoma (PMBCL) tumour microenvironment 3565 3596 3566 7124 3717 4261 6778 5971 5966 965 1233 920 50943 914 8651 6361 PMC6594283__F7 Possible signaling transduction pathways induced by SIRT7 in LPS-treated DCMECs 7099 10454 51547 3603 581 PMC6600375__F1 TGFB/SMAD and non-SMAD signaling 4089 4087 4088 998 9618 4092 2885 57154 64750 5062 2475 387 PMC6600571__F1 Skeletal muscle insulin signalling 3667 208 2475 PMC6607389__F3 Protein-protein interaction network complex and modular analysis 10562 358 6558 1953 1671 94031 83998 5652 4239 8404 11117 4052 5493 23475 60681 5068 1670 5270 6563 1830 5967 115557 5754 1289 5654 5968 94234 2192 4054 8639 2920 4237 7077 8722 8416 4320 1311 1300 4256 6275 3127 115361 474 8792 2919 6370 4323 2817 2633 4923 158326 3122 972 4283 22943 1299 3814 23491 3553 3620 59352 10763 7481 2006 8797 81617 6351 7076 2922 389816 633 7060 7432 834 54829 6424 4105 10267 1906 84624 1066 2786 6352 655 9560 5549 85407 85409 7345 3627 2921 6373 10272 355 100423062 10232 6513 54587 5265 2348 3671 3872 10578 5284 2353 5350 9066 5950 63928 6590 794 1831 3002 4843 94274 3001 1410 25802 1029 727897 79758 80777 10537 10398 4638 6857 3315 55326 8644 72 3303 7298 346606 55808 2936 200958 6876 1674 157313 9415 192134 7169 1917 7145 1028 2170 1264 59 55872 2316 6820 28984 4629 2686 3169 2273 10808 8572 22924 1382 7134 55600 51085 26353 1470 3651 23336 27129 7125 2036 1469 828 29113 27092 1295 3549 PMC6608000__F8 EtOH metabolism pathway regulates KLF4 expression and function 1571 9314 3553 383 4360 PMC6608049__F2 Molecular pathways involved in the maintenance of the MDSC suppressive function.A wide variety of proinflammatory factors are involved in the induction of the suppressive function in MDSCs 3558 3565 3569 3562 3567 3574 4513 6774 4282 972 6772 6778 PMC6610579__F3 Schematic summary of molecular pathways induced by HBx-B genes 10319 3481 3918 6696 6714 239 2308 6822 56924 5058 1576 PMC6611005__F9 Anti-pancreatic cancer pathway of Wumei Pill 3091 1950 1956 2885 4609 3791 1017 4193 7157 842 836 596 572 598 4615 3725 7189 8517 4790 7124 4792 1147 5970 8717 3551 5743 7186 8772 PMC6613878__F1 Therapeutic strategies targeting NAMPT against stroke 10135 952 93100 203447 23411 142 22933 51548 7249 2475 581 PMC6614175__F4 Antioxidant mechanism of the NRF2 pathway 8452 9817 4843 3162 140809 PMC6616367__F1 Tumor necrosis factor (TNF) receptor, IkappaB kinase/nuclear factor kappa B (IKK/NFKB), c-Jun N-terminal kinase (JNK), and apoptosis in hepatocellular carcinoma (HCC) development 7124 7186 8772 8737 11035 23118 257397 619501 4280 7038 8717 PMC6617733__F1 Distinct molecular and morphologic features of apoptotic, necroptotic, and necrotic cell death 1540 7186 10486 64326 8772 8717 197259 PMC6620384__F1 Regulatory mechanisms of Robo4 and their effects on angiogenesis 9353 54538 28964 6091 6714 382 7422 PMC6627192__F4a Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAs 4139 79801 85440 9493 55165 144455 55388 79733 51203 55771 990 9134 890 1831 9837 51053 5933 1033 4502 196 3726 3725 2122 6095 51659 11065 85451 PMC6627634__F1 Diagram showing the different molecular mechanisms of canonical nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation 114548 7124 197259 4615 8772 PMC6627634__F2 Diagram showing the different molecular mechanisms of non-canonical NLRP3 inflammasome activations 114548 7099 8772 6850 4615 10892 3603 3661 3146 PMC6629926__F1 The role of ARG1 and IDO1 in neoplasia and autoimmunity 6714 383 196 3620 PMC6631185__F4 Signaling pathway nodes effected by loss of CDK11 in A375 melanoma cells following PanCancer Reactome pathways analysis 2810 9088 672 2187 9656 8317 1643 83990 891 2176 4176 29089 4174 4171 7465 5983 4436 1017 2189 5984 1031 675 5427 2956 5111 1869 890 4255 2175 595 10459 4609 9134 7518 994 PMC6633870__F7 Genes were clustered in the PPI network according to string database (genes from top 10 predicted pathways in BQG-treated group versus BLM group) 56475 5914 8437 666 2242 581 4851 246744 2885 83667 8440 5863 9020 5603 9612 1030 4133 8325 10298 PMC6637043__F9 Schematic diagram showing the proposed signalling pathways for inflammatory and autoimmunity‐associated gene expression via Ca2+ and Ca2+‐dependent/‐binding proteins 4615 10333 3550 3953 2255 2064 958 831 11146 6774 4775 7124 PMC6647277__F6 Beneficial role of curcumin in cancer 6774 7124 581 2932 324 PMC6647482__F3 The interplay between purinergic signaling and ComC activation during sterile brain inflammation 3146 727 6280 PMC6650088__F2 Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference 5266 5728 207 5295 4352 6418 1118 5290 8490 65986 3776 861 128367 4314 PMC6650964__F5a Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment 55207 506 6804 3002 491 3181 5515 2936 56262 7913 8125 4137 9900 10963 161 4204 5908 PMC6656753__F4 Significant dysregulation of genes involved in Colorectal Cancer Signaling Pathway in urothelial cells 324 387569 572 842 1950 6010 836 1630 4436 4089 581 595 4437 PMC6656753__F5 Significant dysregulation of P53 pathway in urothelial cells exposed to either S 899 1017 472 545 355 637 1869 4609 581 836 842 94005 4193 5371 2241 5728 7249 64326 6477 PMC6657303__F4 Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury 9817 468 83939 581 22926 596 114548 PMC6657977__F7 Circular RNA profile in liver tissue of EpCAM knockout mice 10198 3680 51528 79923 3434 4671 120114 5914 7128 3725 5728 26505 3460 4023 26136 2182 831 140460 253260 6927 55627 130367 3433 288 PMC6658087__F9 Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice 9817 2170 2167 376497 6517 55089 95 51660 25874 3099 401505 100287932 9927 51537 29103 5250 9093 92609 253512 92014 1537 54205 83733 79751 1431 9973 PMC6660363__F2 Serum Proteomics Based Discovery Of Predictive Biomarkers Of Response To Androgen Deprivation Therapy In Advanced Prostate Cancer 3240 197 3043 51478 6774 3848 23592 174 4018 7040 10653 5284 727897 3872 3699 1311 337 6185 10608 1893 PMC6660835__F1 Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS 1843 100873408 1283 29074 7263 57506 29110 PMC6661542__F2 Mechanisms involved in the regulation of glycometabolism in T2DM by RC 2695 7351 3643 3630 3667 406906 5950 PMC6663587__F7 Signaling cascade in RANKL-RANK induced osteoclastogenesis: A model of IRF8-mediated regulation of osteoclast differentiation 7189 23118 3726 4772 1788 4773 3394 9935 604 4286 54 1513 799 81501 126014 PMC6667643__F2 Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis 1435 8205 2571 11201 4282 6774 5340 978 7124 PMC6669485__F9 Summary diagram of signaling pathway of this study 545 9817 581 PMC6676786__F3 The TGFB superfamily in cardiac dysfunction 7046 6010 4087 4088 4089 6722 50507 10631 6943 PMC6678315__F2 Activation of c-Rel signaling by the canonical NFKB pathway in B cells 613 958 5336 695 8915 10892 PMC6678402__F2 Illustration of proposed mechanisms of stem cell therapy in rescuing ischemia-reperfusion induced acute kidney injury 4094 7124 355 7006 100124696 8178 PMC6678865__F4 Altered metabolism as the source of nadph biosynthesis 5226 2539 29968 5723 3417 4199 23530 3418 2805 2806 PMC6678879__F8 miR526b and miR655 overexpressing cells showing significant down regulation of tumour suppressor gene phosphatase and tensin homolog (PTEN) mRNA expression 5728 4513 574468 724025 PMC6679009__F5 Beneficial role of NSAIDs in cancer process 6774 7124 581 2932 324 PMC6679375__F3 Wnt-EarlyEx tumors show expression of Wnt-associated pathway signatures 64840 11197 9350 27123 6423 6424 6425 22943 27121 50964 4041 4040 25805 1454 1855 1856 8321 80319 59343 1857 85409 85407 2535 1460 1459 7976 23401 2932 8322 8312 324 7855 8313 10297 6714 5663 5566 8323 5568 1499 5664 5567 5613 8324 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pathway 572 688 10928 5900 2475 7039 1950 1956 3716 6774 1869 1870 1871 51426 581 4087 4088 675 5888 4089 5337 PMC6682706__F1 Natural plant compounds and epithelial-to-mesenchymal transition 655 3082 7040 4087 4088 6774 4090 4086 387 3611 1000 4092 999 1499 2475 2932 4314 4739 4018 7054 7045 PMC6682839__F3 Cell death and survival in the contrast of susceptible vs 116254 3475 6310 8460 6307 8125 138151 8829 5629 2059 3248 4899 7027 3925 2355 23001 7204 PMC6682991__F1 Representation of the various selenium metabolic pathways leading to selenoprotein synthesis 1733 1734 1735 2876 2877 2878 2879 257202 9403 280636 85465 58515 140606 57190 83642 6414 55829 51714 348303 6415 22928 7296 10587 114112 PMC6683007__F7 Molecular mechanisms associated with acylcarnitine expression in substantia nigra 3 days post-TBI 7099 57512 3146 PMC6689252__F6 Extinction-dependent network of genes in morphine-treated rats 2596 29801 2317 8864 6009 4099 117 7222 9331 8505 56624 5966 10850 245928 23531 152831 51705 54795 115727 1103 2675 9535 2526 1390 4908 79679 10858 7781 2893 157310 4915 126669 1268 5592 1813 4985 PMC6689986__F1 Autophagy in the differentiation/function of osteoclast, osteoblast and osteocyte 650 4090 4086 9474 10533 847 PMC6691526__F2 Impact of ovarian cancer-exosomes on target cells during pre-metastatic niche formation 1499 1386 9112 960 4318 4312 6774 8205 PMC6691912__F1 EV production procedure.Exosomes, 50–150 nm, are initially formed by a process of inward budding in early endosomes to form multivesicular bodies 967 928 975 PMC6691931__F3 CD40 signalling pathway 958 6774 3718 7185 10010 7188 7186 7189 7187 9261 466 4049 3383 2208 PMC6694821__F6 Protein interactome of genes downregulated upon productive HPV16 infection of epithelial tissue types 4319 6947 5270 1491 5646 7263 1081 5744 4692 10135 9118 50863 6016 2525 7164 2524 3553 50848 353134 23764 59277 5583 2877 353135 1839 5228 4791 6288 3918 239 130576 137797 5473 5467 2919 10170 3417 7108 7941 6095 4953 6482 124976 23600 57447 2534 9846 4646 2934 5753 255488 2041 354 3934 1326 7077 5650 8522 7316 2312 57530 133746 7039 267 9076 2065 27134 6275 55432 9931 9948 10457 5106 5166 3434 2520 27242 26525 4599 9407 55655 8638 3437 55601 7358 9636 10964 440 142 2354 6590 9536 5997 10346 8743 56300 3105 91543 4939 8809 4940 80381 7436 3134 10581 7832 4600 10379 3431 5336 126638 4938 54739 794 64135 3665 2081 10451 6890 684 3135 6672 6364 51083 80781 567 54498 1890 3077 30061 PMC6695603__F4 Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC) 1950 1956 2065 2066 1025 983 374 PMC6696086__F5 Signaling pathway regulating pluripotency of stem cells is modified during neural differentiation 8326 442898 407033 5603 54361 650 9314 10297 79923 PMC6696851__F8 Schematic diagram depicting possible mechanisms involved in the anti-fibrotic effect of melatonin and PAA 7471 4088 4087 1499 4092 4040 4041 7045 PMC6709804__F2 Mechanism of response mediated by M1, M2, and M4 macrophages 3716 6772 3717 6773 7099 3663 3661 3565 3603 6778 3718 383 6774 4316 4321 7808 PMC6711114__F1 The main enzyme pathways involved in mitochondrial pyrimidine dNTPs metabolism 780896 7083 7084 1635 1633 978 PMC6712457__F3 Linc00152 promotes the proliferation of gastric cancer cells by regulating the PI3K/AKT signaling pathway 1950 5728 5163 5164 2475 572 1956 PMC6714139__F2 LPS/TLR4 signalling pathway 929 7099 4615 114609 7187 7189 29110 3661 3665 2475 3569 PMC6718311__F1 Pro-apoptotic JNK pathway is strictly restricted in neurons 1843 80824 8739 90427 572 PMC6720185__F1 Stress and depression drive an increase in corticotropin releasing factor (CRF) that activates mucosal mast cells and leads to an increase in gut permeability, coupled to gut dysbiosis and decreased butyrate production 15 196 1545 438 26136 627 5028 1557 3418 PMC6721072__F1 Pro-angiogenic Ca2+ toolkit in vascular endothelial cells 5335 5331 5332 5330 23236 7225 7222 3643 84876 6786 7223 7220 PMC6721072__F2 Ca2+-dependent activation of the extracellular signal-regulated kinase (ERK) pathway and of the Nuclear Factor of Activated T-cells (NFAT) 5335 3643 7223 7222 84876 PMC6721072__F5 Ca2+ toolkit in endothelial colony forming cells (ECFC) 7222 3481 7220 84876 6786 5330 7442 59341 PMC6722120__F4 BC subtype-specific EV protein kinase networks 2932 5747 208 6476 3551 2475 5894 5595 5605 2264 2261 369 10298 1969 PMC6722208__F1 Circadian regulation of hepatic gluconeogenesis illustrates an example of bi-directional regulation between clock genes and metabolism 10135 23411 9575 406 2308 5105 PMC6727029__F2 Pre-synaptic and post-synaptic mechanisms regulated by PPT1 5538 1400 2596 6844 6616 2534 PMC6727143__F3 Ingenuity pathway analysis representation of the most significant pathway in ICH versus CTRL – T cell receptor signaling 940 920 3932 1493 7006 100124696 6461 3702 2885 2534 1445 2922 5778 2002 PMC6735914__F3 DAXX in cell death 7048 7046 355 2495 1616 7186 8737 11035 207 1612 8408 1613 6737 5371 596 28996 546 1786 8554 8772 PMC6737422__F1 SCD-associated oxidative stress pathways and antioxidant systems 6649 50507 6647 79400 847 6648 7099 2242 PMC6745137__F6 Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis 23275 1981 7052 2194 5575 7029 9266 6258 3725 2353 3949 4201 9632 23774 23303 53615 823 1846 5087 84708 3482 91039 412 6497 1453 84749 331 1059 392 6362 7709 4985 54620 2335 3297 140809 7066 23381 9146 5905 3624 6348 5768 54209 84844 1843 6047 8673 3633 4952 7043 3678 7862 1856 1559 2220 5970 3553 1263 7124 3439 5252 6606 5977 PMC6747522__F2 Canonical and non-canonical signaling of FGF23 8074 2264 2263 PMC6747549__F1 Schematic summary of the molecular pathways of F 201633 999 1499 4615 3553 PMC6750278__F1 Diagram illustrating damage processes and pathways thought to contribute to HC loss due to acoustic overexposure 6714 3845 998 387 3725 PMC6750865__F1 Possible integrated mechanism of cell injury and its relationship with microcephaly ZIKV-induced and cell death 2475 207 9447 114548 90865 81030 8737 11035 22926 3659 581 PMC6751629__F8 The role of Asc1 in translation initiation 1998 8661 3921 1999 PMC6752729__F1 Summary of molecular basis on which epigallocatechin-3-gallate (EGCG) prevents chronic kidney disease (CKD) and renal fibrosis based on preclinical evidence 8452 4353 1728 1499 114548 999 1000 PMC6755139__F3 STRING connectivity network demonstrating a protein–protein interaction network of predicted functional partners for differentially expressed genes in the brown module 28984 285381 10169 998 153527 3300 4094 219333 7381 6156 9604 11337 25941 54997 10133 8780 6622 6642 25853 4953 259266 8991 22934 9928 3029 10257 8818 4354 55907 129642 83547 1763 2935 11163 6154 84148 66008 7036 2038 2235 9429 10587 10644 PMC6755252__F5 Signaling pathway regulation network of the three validated differentially expressed tRFs 3667 122809 2817 2872 9575 2254 7048 7039 10718 85301 2247 6416 5495 1870 23365 26060 5293 3480 4193 5337 5604 23566 2549 867 2932 80310 53358 9462 7189 27123 57680 3763 27330 894 51422 6332 1500 2260 7157 6502 2773 3915 7170 8945 85407 23439 4087 109 8324 857 2885 683 59343 64764 6714 3356 340156 6869 2775 3362 11261 3707 108 1128 1956 5499 7169 4040 3269 2977 4846 1857 2774 5481 5170 91807 5261 488 29904 5724 PMC6755339__F2 Main synthesis pathway of n-3 long-chain PUFA-derived lipid mediators 2861 2358 2854 PMC6756575__F3 Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis 157506 162073 1842 1571 30836 4653 3851 11185 54829 4129 3868 4969 54552 4485 51715 64788 590 4092 56928 7257 5479 79442 4053 5168 3855 1311 4613 2304 10631 7247 2266 199953 80271 6696 7026 59 9956 157869 6382 3199 64146 4312 27289 22834 79056 3976 472 1440 608 6092 9590 9353 5078 5350 260436 112476 84824 6659 136647 7341 10010 177 1153 8473 7262 1910 1395 9945 2346 10278 6683 3357 9002 9079 5209 339745 387758 9452 6428 83872 9412 667 57037 23092 140689 155465 81846 6575 4921 2810 72 54205 79191 5727 8988 10563 5806 8836 1524 128866 6330 27123 100652824 124935 10559 57129 PMC6761967__F5 Whole driver PC3-represented PCa signaling pathway 2475 7124 8643 6638 6625 113 6477 6627 51176 4087 9002 783 4998 2907 53358 7029 8911 867 5366 3329 3675 7184 919 5971 29760 29780 1445 9863 7280 147 4018 PMC6765066__F13 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases 3146 23411 3576 3553 4353 4318 3569 7097 7099 54106 PMC6767494__F1 Management of cancer by fecal microbiota transplant 999 1499 7124 6774 PMC6769118__F9 Anti-autophagic and anti-apoptotic pathway activated in human DCs by P 7096 7097 8408 9776 PMC6769516__F5 Pathway of the investigated genes involved in apoptosis 7124 355 8772 84231 6772 5728 841 207 572 840 836 8835 581 842 7157 PMC6770832__F1 Map of potential pathways and their potential interactions activated by a soluble factor- radiation-induced bystander effect (RIBE) signal 7186 7188 8717 3569 4513 23118 257397 10454 3727 1017 1616 1021 1019 4193 7046 5111 PMC6771146__F6 String network of proteins (encoded by the differentially expressed genes (DEGs)) involved in signalling pathways 2487 6934 2079 10494 5617 3815 4254 PMC6785648__F1 Important factors involved in the pathogenicity of septic shock caused by LPS from gram-negative bacteria 3929 5360 3949 3661 3146 7018 7099 PMC6792082__F7 Targeting NRF2 antioxidant pathway for IDH1-mutated cancers 9817 8454 2729 2730 7296 5052 2539 4199 4094 6651 PMC6794554__F1 Wnt signaling with two intersecting networks: Canonical Wnt (or Beta-catenin-dependent) and non-canonical Wnt (or Beta-catenin-independent) pathways 4920 4919 4040 4041 5879 5218 387 1499 998 324 2932 1386 999 PMC6801420__F5 Pathway signaling network generated from the genes located within the top 100 most differentially methylated CpG islands 4909 6608 10818 9350 2322 238 5108 1838 6464 25970 2549 4137 9846 6714 53358 8658 9743 3667 867 868 7409 5777 2778 1859 5499 80351 324 8525 23237 10298 5578 6794 1981 54778 6883 4255 7030 6497 4298 3725 83855 10413 1386 2033 8463 940 84630 2932 PMC6804657__F1 Autophagy induced via cGAS-STING and its signaling pathway 9632 115004 26100 81693 PMC6804710__F1 Canonical and non-canonical Wnt signalling pathways known or needed to be proven to participate in rat tooth germ development.,,,,,,,,,,,,,,,,,,,, 51701 9350 1499 4088 4089 324 50964 25805 6477 6500 8454 9978 23002 9475 27130 387 PMC6810723__F4 Network structure of the 66 genes (left figure) and the top 12 selected genes listed in (right figure) from KEGG “Drug metabolism-cytochrome P450” pathway, extracted using the R package KEGGgraph 4259 54600 4258 2327 54579 1557 1576 54658 2330 4129 1565 1571 1555 1548 316 1544 PMC6811524__F3 Canonical Wnt signaling manipulation during bacterial infection of epithelial cells 324 1499 3569 595 4316 999 2932 10562 596 PMC6811524__F4 Canonical Wnt signaling manipulation during Rickettsia spp 22943 324 2932 1499 999 847 PMC6811524__F5 Canonical and non-canonical Wnt signaling manipulation during E 23002 324 387 2932 2475 998 1499 359948 9802 57492 23135 PMC6812767__F8 Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions 7097 51311 10333 7100 81793 54106 7099 7098 51284 929 4615 353376 114609 54472 23118 148022 10454 7189 5465 PMC6815304__F3 The principal signaling events occurring during fluid shear stress in bone cells 6714 6010 1000 1499 2475 2932 860 4322 50964 PMC6818007__F1 Telomere biology and damage signaling 472 1200 545 25913 7157 983 1017 PMC6818007__F3 VEGF (vascular endothelial growth factor)‐angiogenesis signaling and cell cycle regulation pathways 7422 3791 1956 25913 6714 5335 9542 4609 3685 7157 2475 472 983 1017 545 253260 PMC6821383__F1 Complement system and therapeutic targets in bacterial meningitis 718 727 729 717 1356 730 721 735 720 PMC6822144__F6 Schematic diagram showing role of Tbx15 on adipocyte browning and obesity 367 6913 63976 1386 7350 PMC6823706__F3 Molecular mechanism of inflammatory adipokines involved in the pathogenesis of diabetic associated fatty liver disorders via suppression of insulin signaling resulting in insulin resistance 3553 8660 5163 2475 2308 5091 PMC6824464__F1 Glycolysis and pentose phosphate pathway 2539 5213 2597 3939 PMC6826306__F6 Pathway enrichment analysis of genes with eQTL associations with identified disease-associated SNPs 6891 3932 84876 925 7535 326 920 5897 8625 100 3561 8178 29851 29760 930 958 7374 948 5994 695 PMC6826584__F3 Wnt signaling pathway and its regulation by ubiquitination The canonical Wnt signaling pathway is triggered by Wnt ligand binding to the complex of its receptor, Frizzled, and co-receptors LRP5/6 55366 8549 4041 84133 54894 324 1499 6477 6478 59349 64750 57154 23327 81847 6500 595 8817 4609 83737 PMC6826584__F4 TGFB signaling pathway and its regulation by ubiqutination TGFB released from the LTBP1 complex binds to TGFB receptor II (TGFBRII) and initiates transphosphorylation and activation of the associated TGFB receptor I (TGFBRI) 4052 7939 11124 9146 23327 4089 4087 4088 23077 11059 51592 64750 57154 6502 83737 4092 83881 145258 23462 PMC6826584__F5 Notch signaling pathway by ubiqutination upon binding of Jagged/Delta (JAG/DLL) ligands to the Notch receptor (N1); the endocytic system is activated in the ligand-bearing cell 57534 142678 182 28514 10683 102 6868 4734 4193 222484 4851 9794 1950 8650 55294 9025 3280 23462 83737 PMC6826683__F10 Strategies for therapeutic intervention of cancer involving FADD 3845 8772 6790 699 5347 891 595 331 PMC6826838__F7 Complement and coagulation cascades signaling pathway and RT-qPCR verification 2271 2161 718 2160 7450 2159 2153 5091 727 1431 66037 1380 1361 735 717 730 966 3689 3687 7035 PMC6829368__F9 Network of the glutathione metabolism pathway 4953 79017 26873 6723 2729 2937 6240 PMC6830116__F4 Signaling pathways involved in Epithelial-to-Mesenchymal Transition 3082 1950 1956 6608 4087 4088 6774 2735 9113 26524 4485 8091 6615 6935 6010 998 1000 999 51684 PMC6830349__F3 Diagram that illustrates the in situ flow of downregulated proteins (mark in green) in early development as a consequence of cAMP stimulation 313 6319 47 114294 23560 9575 23761 83743 85476 5188 10531 PMC6831194__F5 Discovery of metabolic pathway identified in both optimal cutting temperature-embedded and formalin-fixed paraffin-embedded samples 4842 7498 5471 384 8833 84706 9615 353 100 27165 440 2744 132 25973 2056 2987 56953 83549 7371 93034 57379 403314 790 51733 978 10873 1737 1723 7372 1738 5313 5091 PMC6831453__F1 Multiple immunosuppressive mechanisms coexist in tumor microenvironment 196 941 940 942 8205 6999 2919 3577 383 1234 920 6387 729230 6347 7852 4513 7422 3146 7099 51311 54106 51284 7098 2475 PMC6831489__F5 Schematic summary of the responses on energy metabolic pathway reprogramming by genotoxic or non-genotoxic hepatocarcinogens in rat liver cells 2539 7157 25874 93974 2744 6510 PMC6838415__F8 Gut microbiota from colorectal cancer patients enhanced the progression of intestinal adenoma in Apcmin/+ mice 4280 324 114548 1499 3553 PMC6848764__F2 Working model for CILK1 signalling 22858 6608 90410 8481 51684 2932 2735 2737 2736 64223 10533 64798 PMC6851227__F1 Metabolic alterations in AML blasts 2744 3417 3099 2539 2475 3939 1431 PMC6851227__F2 Enhanced tryptophan-turnover in AML blasts 196 2475 3620 8564 PMC6857109__F1 The E-cadherin (E-cad) interactions and signaling pathway 1956 1499 2064 2065 5879 324 607 595 PMC6857915__F6 Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease 51701 84133 147111 9350 1499 324 4089 25805 50964 6477 6500 8454 387 27130 6259 7551 PMC6861914__F6 p53 signaling pathway in LNCaP cells treated with LEP (1 × 10−6 M) 1019 1017 472 914 545 637 4609 842 836 317 4193 64065 84883 7249 5728 64326 3486 6477 PMC6862548__F1 Pathways activated by several dysregulated hormones in central obesity 51094 79602 2534 9021 3717 2885 6654 572 6774 5728 6722 4852 5966 5970 4790 581 1147 2475 PMC6873206__F4 YAP regulation by focal adhesion signaling 6714 5163 9113 26524 4771 6010 PMC6873535__F1 RAS-ERK signaling pathway and associated disorders 2885 4763 6654 1431 673 5894 PMC6874879__F2 LKB1 loss alters cancer cell biology 27035 7249 2475 55669 56947 355 8408 9817 PMC6875203__F3 Cross talk between induction of mitochondrial oxidative/nitrosative stress and autophagy 8678 472 3146 857 126669 7942 83636 4281 PMC6879357__F6 Long non-coding RNA TCONS_00000200 as a non-invasive biomarker in patients with intracranial aneurysm 324 4897 100506658 914 941 942 3683 58494 3384 3689 6900 23308 29851 90952 26047 7054 920 958 84628 5817 201633 4267 3680 4359 4099 3685 1000 940 6402 3655 3684 947 23114 214 923 6404 6403 10666 6401 5797 1002 933 5788 9075 6693 3676 3695 PMC6879915__F1 Apoptosis pathway 8772 581 637 317 54623 PMC6881706__F1 Circular RNAs Regulate Cancer Onset and Progression via Wnt/Beta-Catenin Signaling Pathway 22943 693192 100302212 324 10297 1499 100302161 607 595 847 PMC6883319__F3 MetaCore-generated pathway of differentially expressed genes involved in protein kinase A (PKA) signaling 4088 10566 4089 5170 4793 11215 4792 10270 9590 5139 324 5144 5257 1385 3350 572 PMC6883319__F4 MetaCore-generated pathway showing differentially expressed genes involved in sirtuin 6 regulation and function 4899 5932 100187761 10146 9100 22937 468 5741 3383 6648 31 230 2194 5213 3939 3945 1374 3157 948 6319 3949 79071 PMC6883319__F6 MetaCore-generated pathway showing differentially expressed genes involved in mammalian target of rapamycin complex 1 (mTORC1) regulation 1950 2690 1956 7099 185 5763 5338 7189 5170 6885 9053 5598 2932 4133 5879 1431 23770 51256 64798 2475 9894 9675 PMC6883319__F8 MetaCore-generated pathway differentially expressed genes involved in antigen presentation by major histocompatibility complex (MHC) class I: cross-presentation 10525 160364 4481 4065 958 30835 4973 7415 283420 8673 5873 5880 51135 7098 9554 7099 972 7097 4615 51284 54106 23682 115827 8766 10938 382 5867 10981 9363 10890 83871 11021 PMC6883319__F9 Pathway analysis by Ingenuity Pathway Analysis (IPA) 60436 8836 23509 55275 10564 10005 6780 7706 5139 10481 84336 23536 23314 4609 23169 1356 57140 3172 839 80339 9371 3600 7125 355 5326 100133941 5203 4758 PMC6883365__F1 Network visualization of pathways enriched with genes influencing platinum-based treatment response in oral cancer.Hexagon shapes are genes 11197 54331 5336 8787 79971 402 2534 2781 1374 8295 2782 2786 4773 2770 9070 6714 55970 83752 6905 2793 8786 6000 4067 63971 59345 2788 2783 3845 8724 9628 5894 5467 51176 6950 64840 6850 3033 26108 5058 10574 2791 8841 3265 203068 5062 2790 6903 9973 7015 123169 5202 10575 9440 9559 8454 6659 6500 219541 9439 6837 7089 6259 324 8945 5689 1488 9580 23389 51003 22943 5709 9477 27121 23401 55588 10025 84870 9969 5702 892 5465 7534 9968 1387 5707 6095 7334 2535 2932 7088 4041 23097 207 112950 9412 1147 85441 4802 196 9861 8322 84133 5970 55366 6657 57491 1857 59349 6736 4520 8452 5713 8658 10499 25776 405 64750 8323 7314 6423 81847 5716 55553 4862 10454 50964 80306 7514 2101 5708 4800 8463 4801 9915 7316 8325 257397 6667 9101 23054 6658 3551 7003 2779 2784 140805 5996 6468 10681 22803 6904 60 6902 2785 112714 10576 51764 1155 7203 400569 55090 6656 343637 8321 10213 6907 1855 5690 5701 208 4792 6422 23118 5698 25942 5714 PMC6883365__F2 Network visualization of pathways enriched with genes influencing non-platinum-based treatment response in oral cancer.Hexagon shapes are genes 2771 11197 54331 5480 8787 5336 801 898 402 2534 2781 2792 7157 1374 8295 2786 84261 9070 6714 8786 59345 22803 55970 9134 2788 2783 2791 3845 83752 8724 8237 4067 5894 3801 2780 2785 5467 6850 3033 5058 6950 26108 8841 51764 64840 3265 5062 4221 33 2790 6903 1155 54361 7015 55737 123169 7473 5202 51699 7411 6656 7472 83595 203068 9440 219541 9439 6837 84246 7089 6259 23198 324 1488 8454 7091 5709 2033 5684 84870 10309 5465 1387 8321 5715 10213 2535 6095 27123 7088 5696 2932 8322 5701 4520 7855 1857 5682 7314 4802 196 55366 59349 6657 6736 405 23309 8452 5713 6423 208 284654 8658 5468 23118 4792 5708 4862 5698 7316 7514 9915 257397 8517 8463 79412 6658 4801 7003 4899 5170 10238 26330 4773 50999 6904 60 6932 8317 51176 3032 90780 907 58508 5695 9559 9580 22943 54894 5690 85441 3551 4040 134526 84433 PMC6883692__F5 Tobacco-smoking associated genes map to interconnected interferon and stress response signaling networks 710 23328 3454 317 3437 9314 9447 6890 4938 4939 6772 83666 6672 3430 PMC6885086__F4 Effects of sulforaphane on Nrf2 and NFKB pathways 2810 8452 2932 4094 9817 PMC6885354__F4 Analysis of miRNA expression profiles in the liver of Clock-delta19 mutant mice 8850 8467 4204 64105 4617 10735 578 8863 1647 80205 9575 79723 23047 388 9975 5931 4209 6667 11130 9441 29072 5583 29028 6416 5728 2033 8864 5885 6670 50618 9969 5926 23411 5468 5048 5580 5595 867 1408 57551 4783 3091 56670 107 2783 3643 2625 23097 6196 9370 6929 1903 23236 1778 2308 2353 4091 2776 2925 5996 2624 6446 10320 10382 4088 64407 2846 114791 5601 3725 92 147 467 285704 9290 5724 84109 11221 1026 857 5770 5898 5604 4214 2113 8322 4893 2114 3161 7420 10746 5894 5908 3689 8324 8314 10733 128239 10298 6422 9519 7855 2280 4605 10538 22836 27289 253260 3360 8945 23291 133 3082 23049 5515 57826 10000 8312 5592 351 796 650 894 785 4851 7124 1429 8553 5187 658 7532 7525 846 783 6615 390 9475 10059 84549 776 5608 285590 1655 10498 8493 10521 2091 2043 4645 55272 4772 5879 51176 9572 4283 8535 8826 7455 5525 1843 2120 2048 PMC6885770__F1 Nrf2/HO-1 pathway 9817 8452 9978 4094 PMC6886551__F4 Protein–protein interaction network of the differentially expressed proteins between IH-exposed HUVECs treated with or without estradiol (E2) 221927 10907 1477 9736 5781 472 440 10250 8019 2475 84706 3066 64769 1786 57017 51499 80232 5635 6195 84311 6455 29078 7155 64216 1605 57129 79813 23248 390916 114294 79050 58490 400 203 55131 25813 PMC6887802__F4 Infectious lung disease and autophagy pathway 3458 1612 2475 55626 8408 9776 7189 22863 PMC6889432__F5 Notch, PI3K, TGFB, Wnt/B-catenin, and EGFR/Ras signaling pathways are interacting with each other 5728 4092 1956 4087 4088 4089 182 2885 2475 3845 324 2932 PMC6892198__F1 Retinoic acid (RA)-signaling pathway 5950 64220 5959 131 8854 216 220 1592 56603 340665 157506 PMC6892980__F2 Macrophage exposure to Magnéli phases activates gene expression profiles associated with apoptosis and mitochondria dysfunction 4170 581 317 9474 596 7132 598 7124 1540 PMC6893874__F1 Diphthamide biosynthetic pathway 92715 51611 1802 89978 PMC6895828__F4 The cancer signaling pathway and protein network analysis of these up-regulated targets and the prognostic model of the ten-hub gene signature 8740 5900 56477 7039 1236 60401 5778 8844 3718 83593 6376 330 5801 1956 8398 4214 10673 285 4804 100137047 115727 11221 1439 7128 3481 84957 3310 50615 3604 84433 1233 25759 8718 1435 7535 2321 3932 8764 958 7040 3625 7043 6373 4283 773 2829 64926 920 3791 9180 355 3594 3588 3455 3643 5332 7422 53833 10235 627 1380 356 7133 782 51363 970 166012 332 3560 25780 729230 959 11009 3937 50515 79888 151056 6513 3574 5027 8807 27113 952 9619 637 653361 5028 80310 1909 3274 8717 6464 9235 5163 1536 9002 4854 10636 3099 581 54567 112399 9844 1080 146433 PMC6895844__F6 Network and pathway analysis of shared networks between AD and T2D 8726 23429 9782 1974 8452 988 9774 8743 7532 26054 975 6637 10987 6426 8772 27258 8454 23710 2099 4193 51386 6635 84557 11335 1457 55832 3434 6139 7157 55082 409 6160 142 7913 2113 4691 23435 672 7128 8453 3676 11345 23363 6210 7337 10808 51547 3646 351 10250 1994 3106 2885 1956 9636 29760 23643 2335 6133 8976 4609 801 9924 7534 7412 7531 1499 1026 1653 10075 2066 6418 4690 25 5706 9126 PMC6895844__F7 Network and pathway analysis of shared networks between advanced AD and T2D 8467 351 54726 1994 51366 83987 7532 6657 23363 23279 3106 10051 23435 5564 9958 4609 27101 7072 23499 1642 7415 10987 983 79718 6117 6426 51547 22938 5518 8452 7189 5894 6421 2932 1499 9643 5499 6720 2100 805 10971 5295 9774 5599 1956 5515 60 5469 2019 672 5610 11215 5501 55832 3065 2099 892 7531 10013 6256 23122 3164 2064 7412 3320 7534 4343 2885 11140 1432 3676 122809 2263 3326 2648 7529 6613 5747 5879 4067 11051 6259 6850 6622 PMC6895929__F2 Molecular networks enriched by miRNAs differentially expressed in H1299/mutant p53R273H cells 693210 4085 4916 53 7157 407022 3914 25805 391 1462 2051 51684 6209 6442 54468 442898 119504 94121 724027 389692 8774 81539 7227 51809 PMC6895966__F4 Functional interactions network analysis of co-occurring mutations in pre-NAC samples 7531 3845 3326 5970 998 3265 387 2079 2335 5879 5516 2932 6464 5515 867 22938 8650 7046 3516 3065 2033 5901 2146 1616 6118 6117 5925 5984 5981 PMC6896028__F1 Nrf2, through its targeted genes, has an anti-carcinogenic role in the case of normal cells and a pro-carcinogenic effect in the case of transformed malignant cells 9817 468 6647 847 2539 5226 7086 6888 2632 22949 7296 6390 2729 29968 6472 387 4318 2950 2939 1576 10061 55038 3576 7422 4513 9429 2730 3868 PMC6900372__F4 The results of pathway enrichment analysis 387 5880 5879 7006 100124696 399 3676 3684 7852 3689 7070 7408 83700 3683 58494 4267 PMC6900666__F6 CAM signalling pathway identified by KEGG analysis of the target genes of the DElncRNA 324 4897 914 100506658 1000 940 58494 6900 3684 3689 923 1493 29851 90952 920 958 5791 10666 4267 3680 4359 4099 6886 978 3655 3688 6402 948 947 23114 6403 5817 6401 201633 5797 1001 1002 5788 933 9075 6693 PMC6901278__F3 Regulatory network hubs are related to neurogenesis 1002 3955 91584 4851 10716 5048 7476 4853 57534 5649 5728 2572 6586 102 348 793 2173 1956 92737 2735 10371 3398 7477 4861 64067 PMC6901991__F1 Schematic diagram of a cell with insulin/IGF signaling cascades depicted 3490 3486 3479 3485 3481 4074 3480 2475 572 PMC6905465__F2 DNA damage response pathway 472 545 581 5888 993 2178 PMC6907743__F1 Autophagy during viral infection — a double-edged sword 51284 3667 8660 54106 57506 6772 3661 29110 4615 9140 6773 7284 7098 115004 10379 8408 22954 8887 59343 2309 83939 PMC6907743__F3 Autophagy during viral infection — a double-edged sword 7249 8408 9695 9140 7405 3667 9474 64422 8729 345611 55014 9342 29110 5478 7284 83939 PMC6912474__F2 Organelle homeostasis imbalance signaling pathways 83939 6945 7494 468 22926 PMC6912721__F6 Urea cycle and nitric oxide pathway 383 1373 435 4842 5009 384 445 PMC6918076__F6 Schematic illustration of AHR activation modulating HIV-1 transcription 196 1283 405 1025 PMC6918121__F1 Molecular composition, biogenesis, secretion, and uptake of the exosomes 928 967 975 3732 7251 PMC6921965__F1 DSB repair pathways in mammalian cells 672 9156 5426 2237 5888 5893 PMC6927459__F5 Multifaceted activities of CD44v6 in PaCIC 4318 4313 4040 4041 4323 960 1499 387 7852 3611 3091 3082 2885 11140 861 2624 595 572 5467 3481 22943 10413 7046 PMC6927459__F7 EpCAM, claudin7 and their cooperation in PaCa 4040 27123 5587 2274 1499 4072 324 7103 3596 3466 3458 387 3611 5728 3725 PMC6927459__F10 The crosstalk between PSC and pancreatic cancer cells 1950 7040 5270 3480 2744 3091 6510 6566 4190 309 4035 7057 960 19 6506 948 PMC6927459__F12 The impact of PSC and tumor cells on immune cells in the pancreatic cancer stroma 8205 100653366 3565 3586 3596 7046 3569 6774 4089 4087 4088 6362 6367 6356 5111 596 2475 3939 4277 100507436 3558 942 1493 941 3458 201633 102 6868 6678 4513 6387 7039 3500 10631 5270 54106 PMC6928143__F3 PI3K-AKT signaling pathway was involved in NFPA 2885 3611 5728 5478 11140 572 7249 6009 79923 2475 1977 PMC6928941__F2 Ca2+ is mostly involved in mTOR-independent autophagy induction 5212 7942 2475 120892 9776 55626 22863 759 PMC6930256__F6 The networks of the PI3K-AKT signaling pathway related genes, representing the level of regulation of PI3K-AKT signaling pathway related genes compared with the blank control group in haemocytes, at various times when the HdAKT was inhibited by dsRNA 3551 6198 1979 29780 30851 1978 253260 7529 84335 55742 64223 1977 64400 356 1975 3611 6009 2475 7249 7248 PMC6931156__F2 Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTD/ALS) and Parkinson’s disease (PD)-Associated Genes Converge on the Lysosome 120892 6622 2896 203228 84286 23208 54664 51142 400916 65018 25978 29058 10133 29110 2521 5216 6647 PMC6935755__F2 Ragulator complex in SEGAs 55004 28956 3667 8649 389541 7249 7248 153129 6009 10542 6198 5605 84292 673 64121 10670 1978 369 7529 5894 1977 84335 525 528 245973 64223 9821 9776 51382 127124 5571 523 8408 526 5565 90423 9296 51422 51606 5562 842 529 53632 9550 332 5564 PMC6937862__F2 The graphical user interface and output of ZDOG 2885 1435 6654 3265 7097 3492 6850 117145 2932 5290 5170 930 1440 1441 10000 1027 4397 22801 2309 10319 5747 146850 3688 5728 200186 10971 9223 23035 572 4515 10161 842 7248 64223 7249 6009 3667 2475 1978 57521 5894 1977 5578 100533105 6198 29941 6194 1975 672 1017 4846 4193 1147 10488 3164 595 598 596 2997 4609 7157 4790 4170 6256 4602 10018 5934 5105 356 PMC6942807__F2 NRF2-mediated pathway of glutathione synthesis 6520 23657 2937 2936 57716 2730 7295 PMC6942823__F6 Inhibitory effect of Tt-ME in RAW264.7 macrophages 7099 4615 6850 6714 3654 3717 6774 PMC6946788__F2 Decorin and biglycan participate in multiple signaling pathways of innate and adaptive immune responses 7040 7097 406991 27035 114548 4615 2056 3553 PMC6947814__F3 Regulatory roles of cellular IRES trans-acting factors (ITAFs) in EV-A71 translation 3178 2203 8789 PMC6948348__F4 The integrated NSCLC pathway for compound Liuju formula 3553 8717 10682 4513 613 930 3082 4199 2885 4318 10818 4313 7422 10855 PMC6951973__F5 ClueGO pathway enrichment analysis of genes in the yellow module 653247 59272 1470 1803 1824 771 3773 1101 1080 56475 5275 3914 4583 857 1154 10544 717 3081 5327 7374 3868 80328 3872 PMC6952436__F1 Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment 941 942 3932 7535 2475 10538 1017 993 PMC6958407__F4 Proposed model for modulations of Hippo pathway by PDEF 4485 26524 9113 10413 PMC6966193__F2 S1PC induces the degradation of MyD88 and Pax5 by activating autophagy 4615 51135 7494 5079 6347 PMC6966427__F1 B-cell receptor pathway 613 6850 29760 695 54106 2475 5336 4615 3654 3656 7189 7514 PMC6966574__F4 Summary of deregulated genes within different glucose metabolism related pathways and the potential use of certain genes as independent predictors for OS and /or RFS 6514 6518 56606 3101 414328 7086 64080 2539 132158 9104 51071 2632 2998 7360 5167 5834 5836 178 57733 5236 2821 5105 5091 5106 2147 5209 5210 5214 355 229 226 2597 3418 669 47 55753 219 217 223 2023 2027 6392 5166 197257 9122 6567 PMC6970952__F3 Pathview analysis of the EGFR tyrosine kinase inhibitor resistance signaling pathway 1956 3716 6774 1950 7039 2475 6194 1977 5728 5290 572 207 2932 2549 2309 3082 5578 3480 6464 3265 369 673 7422 581 5156 598 2247 2261 596 558 2621 PMC6978517__F7 TGFB2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells 948 4088 4087 2180 8694 6935 123 1000 7431 PMC6981291__F1 Crosstalk between Nrf2 signaling and Mitochondrial function in Parkinson’s Disease 7018 2730 2597 3099 5226 2539 7086 6888 2023 4199 2242 3162 5163 57716 847 6647 22 6648 PMC6981958__F1 Interaction of p53 with different E3 ligases 5548 131405 64326 4193 PMC6985539__F1 Targeting molecules common to pathways promoting angiogenesis and neuroendocrine phenotype in prostate cancer 1113 3170 6790 5925 9480 1385 3066 5979 157 2026 PMC6986204__F2 Molecular mechanism(s) regulating human Beta-cell proliferation 3479 3667 3480 2932 4088 1992 1859 5577 PMC6988017__F3 PPI network analysis 26275 6711 23301 58191 217 64094 6363 9314 55268 5329 7070 6696 1902 115908 5328 3381 7450 2934 56833 3689 7305 929 7412 7454 388 2153 58480 963 4689 1535 5352 5265 5880 257106 2308 4976 972 3983 3122 3109 51196 3108 4318 PMC6996149__F3 Regulatory factors of the acidic pathway of bile acid synthesis 1593 9420 4097 PMC6996360__F2 Genes involved in Wnt, PI3K‐Akt, MAPK, TGF‐B, microsatellite instability, and p53 signaling pathways were differentially expressed during developmental BA 324 1499 572 842 5900 6010 836 4436 1630 4087 4088 4089 2956 596 PMC7010798__F7 Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway 7484 1499 6422 6425 22943 5754 5747 4041 8322 7124 998 51701 864 5468 861 3725 1386 PMC7015151__F1 Outline of T-cell development and T-cell gene regulatory network 3205 4211 4005 4208 8328 3087 53335 6688 3815 4613 4066 2078 3280 6932 2625 64919 51176 2113 5897 5896 4602 2672 861 6938 10320 6097 PMC7016612__F5 Molecular relationship between phosphoinositide 3-kinase/protein kinase (PTEN/Akt) activation, DNA damage and decreased ovarian reserve 5163 3014 5728 472 581 268 PMC7016617__F2 Signaling pathways modulated by SCD1 activity and levels 693185 50507 572 22926 581 468 324 2932 1499 367 PMC7016856__F3 Fibrotic signaling pathways by PKA and AKAPs 11214 9590 387 6098 PMC7017144__F10 Pathway signaling network generated from the genes located within the top 100 DM tiling regions 6356 3084 26291 2668 5786 2066 2065 122953 2064 6714 2908 4067 8728 5901 5580 3745 2289 7443 51684 1499 10298 3693 83478 472 64839 5829 1501 998 6093 5426 5581 1459 1457 6453 55914 3248 4842 421 1263 6591 5327 667 26145 359948 1386 7291 3660 9586 4088 4089 595 6772 PMC7017485__F4 Ingenuity Pathway Analysis showing the plasma membrane and extracellular proteins directly related to YAP1 2246 650 1906 7057 5155 63895 2335 3490 374 7205 9948 3481 4878 6339 1671 5639 9780 10232 11228 4040 9899 999 3480 1756 8239 351 154796 5621 1630 100506658 5727 143098 658 1496 7412 9414 2066 948 317762 1605 8777 3977 1956 4771 56288 7791 257194 375790 1001 10207 PMC7017938__F1 Opioid activity in cancer 6010 4318 4313 7076 1956 4513 5159 6774 PMC7018500__F1 Signaling pathways involved in the recognition of HSV 7097 4615 115004 54106 7098 6772 6773 7187 3661 3665 10379 3716 7297 PMC7020766__F3 Pathway of diabetic cardiomyopathy network (Blue circle stands for breast cancer gene 1906 3816 847 3383 1994 7124 6648 10392 7376 3156 9370 948 817 627 818 51129 7157 9021 1440 4023 2776 2308 22801 1909 3553 6794 3952 8651 2475 5579 10971 2335 3480 3479 23411 6517 1573 6696 4846 1029 7099 185 3630 5054 10062 4316 387 4842 488 489 6347 1636 1647 183 PMC7022273__F2 : Ca2+-calpain, cAMP- exchange protein directly activated by cAMP (Epac)- phosphoinositide-specific phospholipase CE (PLCE)-inositol phosphate 3 (IP3), and inositol signaling pathways of autophagy regulation 5912 9474 7942 2308 2309 23192 10533 664 9140 406991 22863 3725 2353 3146 PMC7022273__F3 Binding of tumor necrosis factor A (TNFA) with TNF receptor activates the receptor, which recruits TNFR1-associated death domain protein (TRADD) 7186 8717 8737 1540 8772 197259 11035 64422 PMC7026421__F1 Rho-ROCK signaling mediates entotic cell death in tumor 999 6010 2271 1611 PMC7027144__F3 Expression profiling of proteome reveals co-expression clusters and functional modules in HCC 64151 10926 3925 9837 4176 4255 8682 1519 11130 34 35 33 PMC7037688__F2 NF-E2 p45-related factor 2 (NRF2) transcription pathway and evaluation of potential biomarkers in Friedreich’s ataxia 8452 2879 9124 4688 2395 PMC7039202__F1 Modular composition of the SGOCP 5230 5232 26227 29968 5723 6472 6470 94081 10797 4522 4524 4548 635 25902 191 1719 PMC7039202__F2 Sources of one-carbon units 157739 6472 6470 23464 8639 314 2731 4522 10797 10841 25902 144193 5860 131669 3034 9 125061 128 6999 PMC7039202__F3 Products of the SGOCP 6472 6470 10797 25902 4143 27232 4837 10400 262 1719 383 10558 6723 6611 100187761 PMC7039994__F7 Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation 2255 112 109 135 2263 2768 2778 2885 5922 10411 6654 5566 5908 22800 5894 673 5605 1852 1850 1845 PMC7045974__F2 Differential dependency network focused on the KEGG apoptosis pathway () 839 355 8772 8717 7186 637 2021 4615 4803 572 472 581 PMC7047088__F3 HIF-mediated gene expression in metabolic reprogramming 768 3098 3099 3939 4601 664 665 5210 5209 5207 5208 5211 5163 226 9361 230 7086 7167 2597 84076 5230 2023 2113 10370 3398 PMC7047281__F3 Interaction network of differentially expressed miRNAs (DERs) and genes 5934 1521 7123 1019 8756 983 894 7124 5595 2353 3726 4922 3481 3643 3727 3725 2885 3667 2069 1956 3845 6464 3265 PMC7048745__F2 Ubiquitination in tumor metabolism regulation 3667 5163 54850 6502 7186 64223 56957 10155 253260 2475 64798 9100 51256 7249 55294 84861 7375 220441 5066 8925 6009 5728 331 7189 11060 11059 1540 7874 8975 7267 23252 8554 29843 4193 8805 57695 57602 57337 7428 9101 10641 PMC7049507__F4 Analysis of miRNA‐mRNA regulatory network concerning Phospholipase D signaling pathway 11069 7054 4254 PMC7053056__F1 Kynurenine pathway represents one of three routes for NAD+ production or recycling 169355 3620 3398 51166 2806 125061 8942 23498 93100 10135 23475 116969 419 420 54956 143 79668 83666 56965 10039 57097 84875 54625 165631 64761 8505 23098 23410 23408 22933 23411 51548 23409 51547 130013 64802 349565 23057 55191 65220 133686 54981 27231 PMC7053436__F5 Central role for Ras-MAPK signaling in habituation learning 673 2736 23126 132 5631 3265 3845 4126 79813 8913 10535 9378 170302 55690 9839 8905 284217 3908 51322 1174 9451 9459 57545 1741 2898 1760 8573 85358 91949 5781 5900 5728 1352 2068 546 7248 4763 PMC7057837__F1 Role of RUNX Family Transcription Factors in DNA Damage Response 545 472 4193 55215 2177 1026 1647 581 PMC7057932__F2 Cellular signaling pathways associated with the mutated genes of the biliary tract cancer (BTC) cases 1956 2064 2066 4763 3845 3265 5266 5296 5728 369 673 2475 4609 1029 1030 472 4193 545 1019 1021 993 595 11200 1111 1869 5925 PMC7057977__F5 COAD “cyan” module APOL6 subnetwork 3434 1890 10964 57674 6376 5610 5371 11274 4600 4599 3433 4939 6737 129607 3665 6373 3620 54739 3431 6672 8542 3437 55008 64135 9636 116071 151636 4940 51667 51056 3627 80830 2634 3430 9246 51513 6772 3659 27074 10538 3717 2633 684 23780 115361 94240 6890 5721 5698 3601 5696 5699 5720 10537 3136 3134 3133 3107 3106 3105 6891 3423 PMC7061741__F2 Hippo pathway in mammals 4088 4087 4086 7003 8463 7004 7005 9113 60485 4485 790 PMC7061741__F5 Schematic diagram showing the proposed mechanism by which the Hippo signaling pathway regulates ovarian cancer 4018 1956 374 9113 60485 4485 652995 154796 2260 2261 2263 2264 PMC7061741__F6 Schematic diagram showing the proposed mechanism by which the Hippo signaling pathway regulates endometrial cancer 1950 4018 3479 79633 9846 51599 158880 9113 26524 595 23499 1000 PMC7062300__F2 MS identification, quantification and analysis of protein meK modifications in human platelets 5550 4397 22837 11011 7171 2937 4082 8499 1072 1832 27072 10487 3702 801 28988 7840 2109 83481 3856 3932 29986 23345 23304 28937 148581 6772 56163 80184 4644 5630 10844 309 10236 5529 79902 9169 1968 3418 4591 5534 1981 1964 10517 5140 7159 29123 10921 6433 7706 8411 124995 4200 1938 10576 6314 3482 64983 100271695 4659 84074 55605 8621 26958 3913 1629 23049 152926 196441 22976 5929 9650 23394 84319 1503 81704 57731 9897 60681 10592 54810 64423 11128 55848 51332 64759 7707 10890 55811 10799 150709 PMC7067536__F7 Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications 7173 64077 741 55647 79803 9249 9665 2304 9931 57082 7939 285527 7392 1435 1649 23762 PMC7067901__F2 Top three molecular networks identified by Ingenuity Pathway Analysis: (A) Network 1 29116 9202 7203 8295 7227 8089 667 7871 6433 PMC7068675__F5 Candidate drug repurposing based on dysregulated lnc-FFLs associated with GDM 4893 6955 2056 2099 100187907 7068 595 481 1499 4351 4609 117247 5295 572 5208 406952 2908 442900 407008 2353 2101 406982 PMC7068866__F6 Metastasis prediction: optimum centered Bayesian network found 7879 7626 8726 27303 144165 29800 80144 4283 30813 85003 11119 285590 5371 130535 8780 51201 3092 355 352909 162972 7086 23210 162073 56981 10824 4093 6696 89796 5648 266553 51752 126299 7528 85478 23072 146434 136259 55038 400238 3788 9355 50944 10584 8974 PMC7072214__F5 Phosphatidylinositol 3-kinase (PI3K) signaling pathway and signaling outputs 6446 572 596 595 1021 1019 PMC7072286__F6 Venn diagram illustrating differential molecular pathways in recGB vs 1493 941 942 3702 3932 919 7518 4437 4436 8930 4255 3364 10111 4361 11219 11277 580 672 545 472 5426 51315 2956 5423 1119 4193 7507 5888 7515 5111 2067 PMC7072361__F1 Potential role of podocalyxin (PODXL) in mature B-cell non-Hodgkin lymphoma (B-NHL) progression 5420 2194 9368 6387 PMC7072578__F2 Autoimmune response signatures for ovarian cancer 7295 378 5004 8614 6288 5284 83719 3959 5310 5054 27244 710 152006 3315 1499 367 4776 823 1519 27346 2099 56950 23543 5728 7114 9168 4609 302 105369343 672 347240 117584 345651 1877 5347 7341 3872 9859 5688 10551 153769 5052 2539 59342 573 5163 51230 7764 4192 7161 10765 64105 10528 4627 8797 10955 55165 813 2936 10642 5451 57521 5725 7405 7157 4666 10294 8079 6426 1981 3856 7167 2023 8880 55544 7431 3306 4194 972 2950 1808 5034 PMC7072649__F1 Pre-B cell leukemia (PBX3) is a target and a regulator of multiple signaling pathways 2322 4318 5728 324 28951 3569 4609 8091 6657 5090 6297 PMC7075017__F1 Fanconi anemia pathway of DNA repair 5893 2175 3398 10293 199990 5888 2177 51455 55215 3980 142 5426 22909 641 1763 9156 4361 3981 7518 PMC7075910__F7 Protein interactions for ECM and summary of regulators 5034 283208 8974 5806 121506 23704 57628 27302 7049 1012 7018 94 51226 51661 54480 1009 7048 7472 5069 2633 5649 3490 654 6678 2321 6401 79586 7045 7078 5817 3479 6354 4060 4015 6347 1604 3426 3082 1129 7276 5648 7035 3486 3732 7052 1508 1052 90865 54538 196883 6586 27286 969 9180 3572 956 4055 3357 85480 8038 3725 9759 6667 5970 3212 40 83716 1641 9464 1268 5087 4915 27253 2847 4212 55083 1306 1277 81578 1281 1278 1284 2200 128553 84620 1282 114815 8633 6909 60482 PMC7076845__F7 Modulating NF-kappa B signaling pathway of DHI against UA 3932 27040 472 29760 695 5336 613 6850 4067 4615 7189 331 8717 7186 7188 4616 1540 7185 128178 10913 7187 7706 3553 3929 929 114609 4513 1270 1950 4803 4049 4050 4055 PMC7080318__F7 LINE-1-induced replication stress 5111 7486 641 55086 55159 55215 2177 545 84126 5810 3364 PMC7082880__F2 Wnt signaling pathways 2932 54894 324 1499 7008 6259 5754 4593 2534 6010 10006 6774 1386 9113 3725 26524 998 PMC7082882__F3 How PHB1 exerts tumor suppression in the liver 5245 10664 283120 3481 4149 4094 PMC7083089__F4 Secondary structures at CFSs can impede replication, resulting in fork stalling and cleavage to cause fragility 545 84464 80198 PMC7086007__F1 Pathogenic mechanisms of CRP causing inflammation and renal fibrosis in diabetic nephropathyCRP binds to FcGRII and activates the NFKB signal pathway to induce inflammation 1401 4088 2475 PMC7086350__F1 DDR core gene amplification across pan-cancer 6996 7374 55775 142 121642 328 27301 221120 545 2237 4255 54107 5423 10721 5426 29089 2175 2187 27434 57697 2176 55120 2072 4683 2177 55215 5395 672 5932 4292 4436 27030 4437 10111 580 7158 2956 5378 9156 3981 83990 7508 2068 2547 7520 79728 675 5591 5893 2067 2074 2073 5888 7516 7517 27343 146956 348654 7518 641 51455 5980 80198 548593 257218 353497 79840 472 84126 8731 11277 11200 1111 9656 PMC7086359__F6 Concerted effects of iAs-induced Nrf2 and HIF1A on glycolytic metabolism 6513 3099 1506 2821 5214 7086 226 2597 619501 5230 5223 2023 2027 3091 5315 5163 PMC7090043__F2 Context is everything: extrinsic signalling and gain-of-function p53 mutants 387 3297 4193 10013 PMC7092503__F7 Differentially expressed interactors of APE1 in colorectal cancer 217 2271 3417 4967 5160 6390 10449 11332 219 1891 1892 1267 11331 10452 1629 4350 6472 7284 471 10134 1152 2109 3033 7416 1192 25932 1656 1854 54927 23203 6188 3420 5250 293 10469 7385 2194 2237 2288 3028 3329 3958 3609 8942 51056 3978 4595 133686 60491 51095 2108 11021 6208 23411 2040 7157 3303 7533 7295 7384 PMC7092629__F2 Predicted protein-protein interactions in aSyn pathology: hypothesis and bioinformatic analysis 6616 9570 2029 6811 5864 1984 6812 162 23020 160 1173 5868 4536 6208 9343 6853 8402 3064 127833 220988 498 7381 509 6188 1653 56993 1965 3920 11315 5250 7386 6855 6804 1915 79751 6228 29796 65018 9627 23001 120892 7384 515 27089 7385 2288 3309 10165 535 8604 6622 523 3148 5441 526 3146 6595 26353 29115 5479 53938 4209 5437 6477 4734 3329 9921 2287 3312 6879 23327 2002 10576 27339 7019 64175 8535 64714 3304 51191 55294 9114 7316 7314 10273 5071 3337 6478 PMC7094289__F1 TLR signalling - TLR1, TLR2, TLR4, TLR5, TLR6 and TLR10 are expressed on the surface of the cell whereas TLR3, TLR7, TLR8 and TLR9 in intracellular vesicles like endosome and lysosomes 4615 114609 51135 7189 7187 3661 3665 PMC7098175__F2 Antitumor mechanism of Tan IIA 4851 1499 22926 572 6502 581 1493 83939 4318 6774 2475 2305 PMC7098175__F5 Antitumor mechanism of Tan I 2002 637 3845 1017 581 2475 6774 PMC7102672__F6 Enriched DGEs in the p53 signaling pathway The DGSs included in the CG vs HS groups, and CG vs HR groups are shown 1017 472 545 637 572 842 836 64065 5728 7249 4193 6477 PMC7103649__F9 Significant correlations between HSD17B4, ACAA1, and PXMP4 expressions and immunomodulator gene expressions 978 8995 608 940 3604 9966 939 3821 80329 8740 3134 7040 8741 3105 8764 3559 126259 6387 4049 8784 22914 30 958 7852 3620 7293 151888 8718 3965 3295 3791 3133 3586 11264 6891 3106 84868 29126 3802 84890 11126 201633 914 920 11148 5817 6892 4277 5133 970 3109 1493 4064 567 PMC7105297__F1 Genome-wide CRISPR/Cas9 screen for positive regulators of SL biosynthesis 9517 171546 10558 53947 2531 7357 64083 9375 10094 10097 196 29956 10096 10093 7360 55275 55858 10787 PMC7105474__F3 Life, death, and autophagy in cancer: NFKB turns up everywhere 7186 857 5970 5971 PMC7106732__F2 Histone chaperone landscape of breast cancer metastasis 999 3169 546 898 1616 55355 81611 4869 7913 6502 5266 PMC7108389__F2 Viral genome induced IFN production pathway via RIG-I and interacting DUBs 9958 29761 27005 9960 1540 7375 5355 57506 115004 10868 11274 7187 29110 3661 3665 PMC7108389__F3 TLRs, IFNARI and IFNARII induced IFN production pathway 29761 1540 11274 7297 3716 8772 8737 7186 8717 7189 10379 10454 23118 257397 6772 6773 PMC7108389__F4 TNFR and TLRs induced TNF signaling pathway 7375 4615 8737 8772 7186 8717 84196 90268 7189 10454 23118 257397 PMC7115196__F6 Pathway network associated with PCOS 3593 6696 2149 3952 5950 PMC7118243__F2 Activation and inhibition pathways for ILC2s 7124 64806 10874 7432 154 367 6772 PMC7118498__F1 TGFB 1 acts as a double-edged sword 3569 1950 3082 2638 324 3611 2932 6773 4087 4088 4090 4086 847 2475 4089 7018 2113 9776 8408 4609 4149 4316 9839 6935 8091 3553 7124 PMC7125019__F1 MTOR signaling pathway 64223 3091 7528 8408 9776 6010 6446 64798 PMC7127985__F1 Molecular pathways involved in PKD, autophagy and apoptosis 572 581 2475 55615 8408 9140 64422 PMC7136098__F1 Canonical and noncanonical signaling options initiated via wnt3a and the concluded outcome 89780 4040 4041 23002 324 6010 1499 4772 9242 PMC7139883__F12 Sphingosine kinase 1/S1P signaling contributes to pulmonary fibrosis by activating Hippo/YAP pathway and mtROS 124976 8877 10413 PMC7140647__F5 Different potential contributing players and their pathways activated in proposed antibody-dependent NK cell-mediated cytotoxicity in the thyroid gland of AITD patients 3107 100507436 4277 7173 6850 5058 PMC7142218__F1 FGF2 functions through FGFR dependent or independent pathways 2261 2260 2263 2264 2247 10818 2885 57506 3661 3665 PMC7142266__F3 Functional domains of BRCA1/2 protein with pathogenic mutations 672 6319 580 5889 83990 472 675 PMC7142847__F1 Metabolic reprogramming in triple-negative breast cancer (TNBC) 2539 5238 2147 7086 2597 29968 26227 5315 4199 440 2744 2875 PMC7145703__F5 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics 142 3932 27040 5335 472 29760 5336 613 4067 10892 331 7132 8717 114609 3929 929 4513 7099 3553 1270 1950 4803 7412 2019 4055 4049 4050 PMC7146986__F9 Mechanism investigation of miR-195 in different stroke mediators, with a particular emphasis on the KLF5/ JNK axis 10371 1524 998 581 688 PMC7154126__F1 Interplay of glycolysis pathway with EMT factors 6935 3101 3099 3082 226 999 2023 PMC7160537__F7 Mechanism of TP-induced lung cancer cell inhibition via ribosomal stress initiation 9349 4193 4691 PMC7166496__F5 Regional signaling pathway analysis of the genes associated with heart diseases 1431 2597 223 1737 226 1738 6389 84532 3417 3030 3032 PMC7166547__F2 Innate immune response and adaptive immune responses of Coronaviruses (CoV) infection during an infection 920 51135 4615 114609 7099 3665 3661 7098 PMC7166610__F2 Illustration of virus activation of IFN‐I synthesis and its inhibition by the MERS‐CoV M, 4a, 4b and PLP proteins 7187 10010 3661 9636 PMC7168569__F1 Regulatory roles and underlying mechanisms of ELA-APJ axis in heart failure 1636 2626 7040 4318 581 PMC7171331__F7 LGR6 KEGG pathway 51701 147111 324 4089 50964 6477 6500 8454 2040 23002 387 27130 6259 PMC7173926__F5 Computational analysis for identification of the extracellular matrix molecules involved in endometrial cancer progression 1303 1300 1305 1310 1306 91522 169044 340267 255631 85301 136227 84570 1280 1282 1401 102 27040 29970 2534 695 4067 5336 391 5747 10235 27035 3690 3674 PMC7174042__F1 Primary motor neuron components and lipidome pathways in MND/HSP 1593 1581 9023 9420 51302 55500 10858 1119 5833 129642 5091 80821 81490 9791 10908 80270 23761 1583 1576 PMC7175140__F6 TGFB non-SMAD signaling pathways 64750 4091 7189 9618 4092 2885 7018 57154 998 387 5879 5062 6774 PMC7175458__F4 Classic AHR signaling pathway 5053 196 405 57491 PMC7176878__F2 NFKBIA is involved in the NF‐KB signalling pathway 3932 142 27040 5335 472 29760 695 613 6850 4067 5336 4615 7189 7185 331 8717 7706 4513 3929 929 114609 3654 51135 7412 4803 1950 7186 7188 4049 4050 4055 7187 PMC7177584__F1 PRDM proteins contribution in the mechanisms related to invasiveness and metastasis 2064 5971 639 653 999 5058 7799 63978 11108 59336 3689 7076 7077 4312 4313 2534 257106 PMC7181582__F6 HIF signaling pathway and upregulated DEGs in HIF pathway from KEGG enrichment analysis of R 6774 3569 7428 2056 7018 7037 100306940 2160 2475 81553 5163 5211 2597 226 3939 PMC7181582__F7 NFKB signaling pathway and upregulated DEGs in NFKB signaling pathway from KEGG enrichment analysis of R 1610 114034 27040 472 29760 6850 613 4067 7189 8717 7706 3929 929 100187907 4513 695 1270 4803 1950 958 7187 4049 4050 4055 PMC7182350__F1 Rac GTPase activity is regulated by synaptic activation through synaptic receptors that are known to be involved in memory formation such as NMDA, Trk, and Eph receptors 2043 2048 7074 10152 23191 627 PMC7187988__F2 Hormonal control of adipocyte lipolysis 3667 8660 2638 116236 5140 2191 51099 5346 57104 4099 PMC7189569__F4 TNF signalling pathway 7124 8772 8717 7187 7186 8567 637 2002 317 5743 PMC7189706__F5 Hyperglycaemia may influence ten-eleven translocation (TET)-dependent O-GlcNAcylation of the histone methyltransferase SET1/COMPASS complex 8473 54790 200424 PMC7190874__F10 Liver analysis 2328 2099 3304 3320 7316 PMC7190874__F4 Heart analysis 148523 941 1628 1813 6122 29765 1407 4783 467 930 9499 3312 3304 2247 718 3725 3320 4318 4828 6155 6139 6152 2268 474382 10412 6136 PMC7190874__F7 Kidney analysis 5166 2167 1149 4852 3484 7350 4023 6678 1277 2194 3687 5105 2200 1278 7316 2335 PMC7191095__F3 Main signal pathways of YTHDF2 in human cancers 51441 999 1000 1956 619501 56339 100187761 6416 8835 3553 828 PMC7192886__F1 Immune responses induced by radiotherapy 8205 3146 7099 472 545 115004 3659 1956 3458 PMC7192953__F4 Pathways of DNA double-strand break repair 142 3981 672 5426 675 5888 PMC7196551__F1 Natural products targeting different cell signaling pathway 6098 260431 1956 3479 238 4088 4087 3845 1080 2625 6778 PMC7196612__F2 Virulence factors of Fusobacterium (F.) nucleatum 201633 4615 8408 10533 PMC7201093__F1 Summary of the mechanisms that myocardial protection mediated by melatonin through receptor and non-receptor pathways 4851 9927 23411 627 581 572 355 4170 23410 2932 6095 6262 3717 PMC7204005__F4 miRNA-28-3p promotes cell proliferation and migration through the IGF signaling pathway and participates in the regulation of diabetes 3480 3479 3481 5728 2885 1398 5163 572 2475 2932 1977 2002 PMC7204879__F4 HCoV-host interaction 468 22926 83939 596 581 5355 PMC7210457__F5 BT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells 947 26869 26864 9311 26834 26832 387914 83667 5228 55620 493829 2043 26835 26827 79924 8614 6854 64084 7483 214 2494 64359 29968 78990 8718 3912 8975 PMC7211317__F8 Schematic model for the ability of RTR-1 to induce cell cycle arrest and apoptosis 6774 581 472 PMC7212029__F6 Wnt negative regulation in ligand-dependent (LD) and ligand-independent (LI) tumours 147111 55366 8549 54894 4040 4041 324 85407 847 PMC7216265__F1 Canonical glutaminolysis pathway 2875 4199 27165 2752 4190 2744 4191 440 3418 50 5625 468 47 84889 48 2194 3417 PMC7216814__F7 Network regulation map of downregulated miRNAs, SOX2, and other genes in the platinum drug resistance pathway 472 317 5170 54205 4437 596 581 10000 331 356 7153 8772 842 PMC7218232__F5 Metabolite and miRNA changes associated with 3R4F CS-induced immune response 48 50 3418 3417 219972 2628 4843 383 384 4942 4953 5009 112483 6303 6723 6611 474168 PMC7218999__F7 Protein-protein interaction analysis based on STRING with an interaction confidence score (0.400) 56922 8802 374291 4513 5315 7086 5164 231 2739 6188 7341 7311 4691 5814 PMC7219856__F1 Interactions between the renin–angiotensin–aldosterone system and coronavirus Disease-2019 1636 59272 6868 7113 PMC7223178__F1 Mammalian TLR signaling pathway 4049 81793 7099 7097 10333 7096 114609 4615 51311 51284 7189 1896 7187 29110 7098 3661 3665 PMC7226088__F2 Regulatory signaling pathways in MDSC development and functions 3569 3603 3716 3717 4615 11035 6772 6774 383 4513 6279 595 PMC7226520__F3 Adipocytokine signaling pathway in humans (KEGG hsa04920) 2475 8717 7124 7186 9021 3952 3953 6774 181 4852 5465 PMC7230488__F2 MAPK signaling pathway with nodes color-coded based on the z-value obtained from the meta-analysis of the GSE53987, GSE12649 and GSE21138 datasets 9020 4790 1147 5566 10368 4137 759 9693 5923 10125 2872 468 369 5604 1435 2885 6654 673 6722 2353 5605 2005 5894 4609 4763 2768 1845 11221 5921 2316 408 1398 4775 6416 3727 5609 5058 1386 5494 2002 7124 6788 10000 7157 8717 7186 5606 356 355 1616 7040 7046 4149 5608 10454 4208 929 23118 7189 3315 51295 51347 51701 PMC7232598__F4 Ingenuity Pathway Analysis (IPA) network diagram of differentially expressed genes in patient vs 5230 4853 196883 55872 1601 414325 55894 8493 134510 4751 6283 9101 2189 1033 4860 51247 55610 10600 84233 PMC7243914__F4 Immune signaling pathways in bovine monocytes 3458 54106 6772 7297 4615 3654 51135 7189 126669 PMC7244458__F2 Mast cells (MCs) respond to a wide range of pathologic and environmental stimuli owing to the expression of toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs) 2534 6850 4067 9846 2885 7098 51284 1232 1233 1234 1236 3383 3577 3579 2833 10663 PMC7247338__F3 Proposed miRNA–mRNA interaction network of the 10 most abundant differentially expressed miRNAs (DEMs) with their potential target mRNAs 11124 10643 4208 9314 203238 8087 4478 1871 4661 4641 11278 22863 659 4628 124808 6935 9706 4627 79577 8491 1810 23531 7042 4154 23040 8621 1983 84441 5530 1998 5033 389058 26153 6093 27295 1977 3313 54207 2353 8445 PMC7253212__F5 Interaction of FXR signaling and pathways relevant for zileuton-induced hepatotoxicity 1555 1577 6416 3557 5360 5164 3030 4609 10257 6584 33 37 1374 51 2168 6927 3990 6720 123264 8647 1244 7364 5468 5465 2877 3988 7365 6928 948 376497 11001 3479 9429 10478 255189 1066 PMC7254050__F5 Proteins co-associated with hyaluronidase (HYAL)-2 have roles in actin organization and contraction function 139741 71 7414 728378 3927 387 8692 PMC7266824__F2 Ibrutinib in Chronic Lymphocytic Leukemia: Clinical Applications, Drug Resistance, and Prospects 3570 3566 613 4067 6850 3716 3717 695 5336 6774 6778 8915 10892 8517 3551 2475 4792 5970 7514 PMC7267026__F3 Positive and negative regulation of MAVS activity antiviral immunity 57506 54726 8473 11074 6737 57154 11124 5879 51701 5494 23170 204801 51035 7186 7187 7189 7188 PMC7268632__F2 Endoplasmic Reticulum (ER) Proteostasis Network 22926 7494 7186 51493 83939 468 PMC7270498__F2 ncRNAs Regulate Cell Death Pathways to Influence HCC ChemoresistanceMultiple miRNAs and lncRNAs act as mediators of the autophagic process in HCC cells by regulating the PI3K/Akt signaling pathway 356 355 255082 8772 94241 100885779 60674 100507246 102723932 5728 637 23642 283131 581 2475 171423 8408 84971 55054 9140 9474 728655 378938 PMC7272282__F2 Cell cycle checkpoints 1021 1019 472 898 993 1017 6741 545 7465 995 983 PMC7275976__F1 SARS-CoV2 replication cycle and potential targets of CQ/HCQ 1636 59272 51284 PMC7276052__F7 Main components of RAAS pathway active in small bowel (SB) Crohn’s disease (left) compared to non-IBD (right) 59272 1636 340024 PMC7277336__F1 Signaling cascade of insulin-like growth factor 1 (IGF-1) and its potential impacts in metabolism, its interactions with transforming growth factor B3 (TGFB3) and the biological functions of the IGF1, IGFBP2 and TGFß3 genes 3479 3480 7043 7046 3667 2475 2309 2932 572 PMC7277693__F5 Schematic view of genes downregulated (green) and upregulated (red) in the biosynthesis and degradation pathway of cholesterol 3157 3156 6307 4598 3422 1718 2222 1717 4047 9023 PMC7277712__F6 Bisphenol A-induced synthesis of steroids: The bisphenol A (BPA) spreads out through the membrane and binds the cytosolic multi-protein aryl hydrocarbon receptor (AhR), allowing its release in the cytoplasm by the heat shock protein (hsp)-90 196 405 6770 706 PMC7279704__F1 Simplified representation of mechanisms of DDR and DNA repair 3479 6741 545 1362 4968 7508 2071 2072 7520 5888 79728 672 675 7015 PMC7286357__F8 Proposed mechanism by which Xbp1s promotes inflammation and injury in renal tubular cells during AKI in sepsis 7099 929 3929 7494 6928 9021 PMC7287266__F1 Retinal Degeneration Caused by Rod-Specific Dhdds Ablation Occurs without Concomitant Inhibition of Protein N-Glycosylation 38 39 3157 3156 3652 4598 10654 8813 4597 1798 29880 116150 79947 2224 22845 79644 2222 1718 1717 PMC7288469__F4 CFTR Proteostasis Interactors 6850 3315 54788 80331 3337 84447 3301 1080 9919 79139 91445 117584 9100 10228 8678 1601 25942 PMC7288655__F9 TGFB signaling pathway 148738 4089 25805 2444 3458 8454 6500 7046 2331 387 10468 5308 4838 PMC7288943__F8 Schematic diagram showing the mechanisms by which S58 promotes antioxidant defense of HConFs against fibrosis 7048 847 2876 PMC7288973__F8 Schematic diagram depicting the anti-PCa mechanism of C10 596 581 841 836 3569 PMC7290906__F1 Polyplex internalization pathways, driven by mediators, cytoskeleton movements, and GTPase signaling 387 998 5058 PMC7291227__F3 Ingenuity Pathway Analysis (IPA) gene network analysis 3816 9589 7113 84619 81603 354 10713 55178 4017 5083 8887 10868 200916 8031 6662 27349 7942 389136 6122 254827 27348 5711 4650 253461 10611 405 6950 8607 221895 222194 5820 50628 100287932 4609 54801 440 23315 55275 2644 11056 115752 6203 3201 80742 79954 PMC7291227__F4 Ingenuity Pathway Analysis (IPA) upstream regulatory analysis 3817 1280 354 2705 11074 80352 1513 2644 3065 430 6899 4609 6910 7015 405 6662 7091 4172 4824 PMC7293352__F3 Inositol phosphate and phosphatidylinositol signaling pathways in metazoans 3630 3612 3613 3628 5266 253430 5728 PMC7294576__F9 Beta-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NFKB Signaling Pathways 581 1000 999 79923 960 PMC7298716__F9 DINO regulation in HPV-positive cervical cancer cells 472 4193 7157 1026 PMC7299160__F11 Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis 7124 10454 23118 8717 7186 8737 8772 841 11035 4193 197259 581 23657 836 5037 2879 6520 2638 10162 2182 PMC7299830__F3 Eribulin combined with irinotecan inhibits DNA replication and induces TP53 pathway genes 7124 613 958 1386 1869 133746 9734 355 64065 581 2765 10274 9997 5111 8554 5728 2932 7490 672 3091 4193 1499 4194 5371 PMC7300250__F1 Signaling pathways regulated by Shp1 6714 5879 6774 1017 1021 1019 596 999 PMC7300384__F2 Epigenetic and epitranscriptomic pathways depend on metabolism 54790 1786 23409 3065 23410 51564 55902 2874 5132 47 3417 3418 10135 23057 PMC7300552__F1 ACE2 function and its regulation in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection 59272 1636 545 7113 PMC7303083__F7 LPS-TLR4 MAPK pathway stimulated by 1% ECVE treatment of LPS-matured MoDCs 3146 4615 51135 3654 3656 7189 23118 257397 6647 PMC7305909__F1 Virus-based and host-based targets against the coronavirus replication cycle 7113 59272 1803 5045 5478 PMC7306500__F2 Protein-protein interaction network (STRING database) generated by combining all biomarkers of different omic types, reviewed earlier in the report 27130 146 23077 112724 1044 394263 7472 1628 11182 6611 5714 5682 10063 64111 467 5707 9956 4791 10935 1583 283571 847 1392 3336 3623 2730 2167 29995 9024 7431 10272 2259 7037 5265 3240 490 113026 345 8553 8863 10761 7078 6513 1444 971 7276 54414 8038 259 2053 3860 824 4232 214 29952 60676 8764 PMC7310212__F1 Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma 2475 3480 3479 5728 6009 7249 7248 1977 5163 4485 9113 7003 6010 PMC7312293__F2 Key negative and positive regulators for NLRP3 inflammasome 2167 29933 5091 7351 50507 1374 10558 114548 PMC7312739__F1 Transcriptional and posttranslational regulation of programmed-death ligand 1 (PD-L1) by Nuclear factorKB (NFKB) 3458 4582 1956 602 PMC7312739__F2 Combinatorial treatment approach of Nuclear factorKB (NFKB) inhibition and immune checkpoint blockade 3458 1956 4582 602 PMC7316979__F3 Interaction networks from significantly upregulated serum cytokines from cancer survivors 6361 1803 2022 959 9173 6374 7412 1116 5155 5154 6387 335 7033 1950 6696 4318 2638 5175 1401 5054 5950 627 9965 5329 9518 682 7036 PMC7318773__F3 Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers 3586 3466 10333 7186 7189 6772 51701 6773 3661 29110 7187 10454 28512 55922 79589 581 149428 598 79370 84851 3097 284340 58191 374383 PMC7319280__F7 Systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics 472 4193 5008 PMC7319585__F2 Molecular steps of FEME carrier formation 1020 274 2932 998 5266 23616 4983 PMC7322824__F1 STRING connectivity network analysis identified protein–protein interactions between CUL2, EGLN1, RBX1, LDHA, TFRC, and PFKL 8453 9978 54583 8569 5605 3939 7012 5211 PMC7324848__F10 P-TEFb complex activation following activation of the A1-AR or ETR 1025 23476 27125 7018 1283 PMC7327052__F2 Centrosome aberration-associated molecular pathways in cellular senescence 121441 55125 5108 PMC7330943__F8 Estrogen signalling pathway (a) is solid active instead, prolactin pathway (b) results are not in the group of the strongest expression level 108 162605 3861 4313 5894 4893 6654 1386 7054 6655 3866 2592 8835 3306 342574 5618 2353 3845 3265 4170 1147 390792 5603 PMC7333287__F9 PI3K-Akt signaling pathway influenced by XLGB 6009 2885 4846 1956 1950 2932 4609 1017 3717 572 596 6256 4193 7157 PMC7338604__F2 Natural products targeting the Beta-catenin signaling pathway for cancer therapy 999 5493 1499 6134 PMC7338975__F1 Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease 2937 23657 9817 2729 2730 2512 3315 2879 55240 3658 2936 2495 10533 9474 8031 10162 100 PMC7339600__F5 Protein-protein interaction network for the DEGs in the brown, blue and red modules 81615 56925 51480 116843 23632 973 140679 81027 952 2251 57571 8829 22918 2805 2705 1003 3815 5213 1160 440279 245973 3791 5315 1956 4162 4190 8789 2274 5624 292 22795 8554 3910 5224 367 1543 125 6357 267 5577 2791 2660 7171 5143 6720 5358 127294 2053 4892 85366 163259 219537 340156 10286 1260 253559 135228 PMC7340521__F7 Dual RNA-seq provides novel insight into the roles of dksA from Pseudomonas plecoglossicida in pathogen-host interactions with large yellow croakers (Larimichthys crocea) 7124 4049 8772 8717 7186 7187 843 841 23118 257397 10454 840 197259 83737 2921 2920 2919 3627 6376 7128 7185 9021 3569 3600 3976 1906 3383 355 4314 4318 4323 1435 6401 8809 64127 1437 182 PMC7343183__F8 JNK pathway plays a key role in the immune system of the pea aphid and is regulated by microRNA-184 3725 2353 847 57716 10652 PMC7343490__F2 Network analysis including the 125 differentially expressed proteins at 24 h after SARS-CoV-2 in Caco-2 cells 11113 6790 25879 7448 9643 5435 1050 387 335 334 336 10274 7276 6667 5903 9212 57405 3918 10600 6385 2719 348 11065 4036 174 4052 5660 2159 3861 4734 183 PMC7346436__F8 Pathway signalling network of the common gene regulators associated with the top-ranking 100 CpG sites 9353 3566 54538 2066 1956 7175 5311 50937 5310 3745 5580 8945 4067 5007 5613 9901 9212 5305 25 10458 9043 5909 8936 814 9759 2706 27236 1785 23164 55183 2017 1499 23370 472 4217 63035 5595 94274 6093 5566 3717 695 817 51651 23139 335 10014 54434 5793 5298 10395 23002 5728 572 84441 5335 1487 57492 6418 26040 5970 4205 8648 6615 3516 3718 4208 2908 6776 9612 50943 4209 860 79365 PMC7348946__F1 Simplified overview of NK cell activation by the NKG2D pathway 80329 80328 79465 4277 100507436 2885 7409 PMC7348946__F2 Simplified overview of the TCR and CD28 signaling pathways in T cells 942 941 920 940 3932 PMC7348946__F3 Simplified overview of the CD28, PD-1, and TCR signaling pathways in T cells 941 942 940 3902 30009 PMC7349681__F2 Types of extrusion 999 6010 9294 PMC7350257__F4 PI3K-AKT-mTOR and WNT signaling crosstalk 4040 4041 7249 2932 324 1499 5728 9675 64798 9113 26524 4609 6659 1956 367 3939 1019 999 PMC7351433__F1 Simplified scheme of cellular pathway and the targets of MTX 5981 9429 2356 8836 4397 1719 4524 4522 7298 471 PMC7352479__F1 Glucose metabolism 3091 2719 3099 3098 2539 5211 2203 2597 5183 3939 PMC7352604__F4 Wt TP53 LUAD females are enriched in antigen processing and presentation pathways with links to longevity 3458 811 6892 821 567 1512 920 3123 7124 203328 7157 PMC7352732__F4 K-ras transcription regulation roadmap 5324 468 150094 23387 26824 26871 10645 2023 5230 2597 3939 2879 200186 2475 467 1373 3226 9817 79728 571 134 154 23657 6520 PMC7355739__F2 Modeling of the multiple functions of Reelin during migration, dendritic growth and synaptic development and the corresponding signaling pathways: (A,A’) 5818 25945 1600 1398 200933 1356 6453 30837 998 2475 6845 6616 23426 7436 PMC7359798__F2 Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids 7098 1665 170506 8635 51311 6036 54505 51284 7186 57506 8772 7189 29110 80231 3663 3665 4615 3661 1660 171389 338321 439996 3434 3433 24138 10521 56919 6041 6035 114548 54464 167227 81030 11035 197259 PMC7359798__F3 Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids 1777 54106 23646 122618 57506 25939 4615 9447 7189 80231 11277 3665 3663 10146 3603 85364 115004 3146 4841 200316 327 7019 3428 114548 29110 10111 3661 64170 8915 PMC7362612__F1 Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target 7124 8717 7186 7185 8737 331 10133 9825 81858 1540 29110 9755 23118 257397 90268 11035 8772 841 57162 PMC7366109__F5 KEGG signaling pathway enrichment network of Pre-No 2475 5728 5468 6256 4193 2920 959 1733 3565 5925 5581 3643 572 1950 7422 5465 4609 5328 4846 2100 5292 3791 598 7157 5596 2353 6347 5578 847 3725 5970 PMC7367602__F1 Microarray-based Analysis of Genes, Transcription Factors, and Epigenetic Modifications in Lung Cancer Exposed to Nitric Oxide 29953 10750 3297 9625 9365 131566 5350 6427 5640 5355 PMC7367812__F2 Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions 56832 3466 59272 7097 7113 7098 8717 7187 51311 51284 7706 843 840 7189 7186 836 4615 637 51295 6773 29110 10379 3665 3661 3627 9636 10581 3669 PMC7368967__F10 Mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation 3065 659 4090 4086 3066 2475 3398 1616 PMC7369905__F3 NRF2 regulates metabolism 5226 2203 2147 7086 6888 5471 10797 3992 79993 2023 387712 5105 4199 5315 3417 27165 6510 2730 2729 2512 23657 2937 847 6647 84706 PMC7374090__F3 Development and implementation of the SUM breast cancer cell line functional genomics knowledge base 29945 9978 8697 8243 29882 7975 4118 545 9126 4176 4171 5347 8881 701 5111 5885 9184 85417 8555 1875 10393 7709 246184 991 PMC7378646__F2 Crosstalk between the Hippo-YAP1/TAZ pathway and Wnt signaling 1499 4040 4041 4485 324 10413 1856 9113 26524 387 PMC7378646__F4 Crosstalk between the Hippo-YAP1/TAZ pathway and GPCR signaling 4485 7204 387 9113 26524 10413 PMC7379631__F3 UPR disease biomarkers and therapeutic targets 10130 10954 22926 84699 83939 7186 6721 51493 468 2735 7528 2308 3091 6722 PMC7381294__F5 Differentially methylated genes enriched in the insulin signaling pathway 3630 7248 6009 2475 5163 7249 355 1977 5183 5164 2308 PMC7381748__F2 TPL2 signaling 958 671 4513 2919 3553 2932 3725 6774 6935 4772 7852 1956 4318 4313 PMC7384693__F1 Merged Networks (Core of #1 Overlapping Networks) 3558 7077 3976 56034 2250 1008 91419 1244 3791 2907 6513 51447 6955 330 3162 79026 2744 10010 837 638 25961 440 7114 54541 9829 10370 6927 6667 4772 2099 6720 55294 7465 2078 1649 4609 4913 3399 468 23028 694 5111 672 11335 1874 10155 51592 2074 6907 140462 1791 3149 84441 PMC7391449__F1 Cellular Oxygen Sensors 3091 2056 3099 664 7037 PMC7393197__F3 Antitumour peptide based on a protein derived from the horseshoe crab: CIGB‐552 a promising candidate for cancer therapy 150684 5868 581 6647 842 841 836 PMC7395594__F2 Nrf2-ARE and Wnt/Beta-catenin/GSK-3B intertwined signaling cascades 324 9817 4094 PMC7397164__F1 Canonical and non-canonical Wnt signaling pathways 4040 4041 6259 23002 324 5879 998 387 847 51701 PMC7399097__F3 Interleukin-17A signaling transduction pathway 84818 7186 572 790 9618 7189 10865 1654 23118 257397 PMC7399876__F1 Tax activation of canonical and noncanonical NFKB signaling 23705 7189 9025 8887 23118 10454 1540 9100 64236 PMC7400736__F3 Interaction network of the let-7 family targeting the IGF family members generated from HMDD version 3 596 58 6648 3479 1406 1906 4352 2043 4194 4607 4193 900 384 3596 836 595 1026 22806 3480 3481 8289 1174 3845 1848 26136 2395 2019 598 2149 694 PMC7400772__F1 Immune evasion in EC 6890 6367 3586 94025 84166 100188864 PMC7402324__F3 Proposed model of the crosstalk between canonical and non-canonical WNT-signaling in melanoma 1000 1499 382 6478 960 4286 607 4040 4041 4920 PMC7403443__F1 Crosstalk between intestine and liver in the pathophysiology of NAFLD 8213 9965 5465 9294 7099 2695 PMC7403780__F6 Recombination salvage pathway regulation 5111 118027463 5893 5888 PMC7403894__F1 Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies 7096 7097 10333 7099 114548 3297 23411 2932 338386 PMC7404091__F1 This figure summarizes the regulatory core of ferroptosis, approximately divided into three axes 2879 9817 6303 246 121549 10162 7018 8031 10533 9474 PMC7404843__F1 Immune responses and immunotherapy strategy in SARS‐CoV‐2 infection 59272 3455 3454 920 59272 920 3455 3454 PMC7407626__F4 Summary of intrinsic apoptotic pathway 54623 717 581 PMC7408838__F2 SRC-mediated molecular pathways formally assessed in malignant mesothelioma (MM) 6714 1021 1019 595 6774 10631 999 PMC7409324__F2 NFkB-induced expression of MHC-I 7186 7189 5970 5971 PMC7409324__F4 Therapeutic interference to boost MHC-I antigen presentation of tumors 3458 5311 5770 5771 83737 5781 3716 1540 3717 10318 6045 100288687 6774 6773 6772 9683 10379 1956 57154 3659 3661 5300 5970 PMC7409586__F1 Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency 60678 118672 79048 22928 51091 54952 9775 4691 6156 PMC7410257__F7 Kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media 1956 2885 3718 3265 3932 2475 7462 7124 3725 2353 6722 PMC7411231__F1 Regulatory interactions of the HSC model 7173 472 1499 2932 1026 4193 1027 2672 1028 648 7157 898 1032 54205 1029 595 PMC7412871__F3 Transcriptional Regulators of Ca2+ Homeostasis 613 5971 2002 1958 6007 6668 10763 8760 6670 1040 6667 PMC7415495__F6 Molecular mechanisms underlying Beta-cryptoxanthin inhibits A7-nAChR, thereby leading to the inhibition of lung cancer progression and metastasis 572 581 4513 4318 4313 4321 PMC7419604__F2 Communication between the GI tract and the brain 5697 3553 885 196 PMC7423166__F9 Mechanism for hepatocyte PPARA activation on BA synthesis and transport regulation 1581 1593 4945 80270 9420 1582 64240 64241 570 5465 PMC7423983__F3 Function of SIK1 in tumorigenesis 150094 759 1499 3397 8841 3569 7291 999 6935 9839 51176 6925 PMC7425198__F6 Effective Method for Accurate and Sensitive Quantitation of Rapid Changes of Newly Synthesized Proteins 6364 6352 3553 7124 3383 5743 10270 1959 6018 7991 201595 2683 56052 5589 3159 4904 84656 5970 171017 54927 6175 23521 6138 6230 6128 6164 10294 10427 3301 51726 6400 5356 10772 3183 1655 27316 11231 6238 3192 10992 6432 55696 10250 9972 4928 57122 5901 23279 PMC7432012__F3 Tumor necrosis factor beta (TNFA), interleukin 1 beta (IL-1B), bone morphogenetic protein (BMP), and transforming growth factor beta (TGFB) are stiffness-dependent signaling pathways 3553 4090 4086 10454 4087 4088 4089 1386 860 249 1300 4322 PMC7433558__F4 IVF-ET对胎盘绒毛FAK信号通路基因表达的影响Effect of IVF-ET on gene expression of FAK signaling pathway in placental villi 7408 6714 3611 1499 998 5728 1398 673 2885 572 596 PMC7436103__F5 Signaling transduction and pathway network of co-expressed lncRNAs and mRNAs in AGPS-silenced U251 cells 780904 2475 23327 285 3383 2247 4832 2069 53358 5829 7057 83660 79077 205 6696 58494 3480 1956 6385 22801 10135 7098 6347 79646 5580 9547 3554 5167 1278 7358 5290 3553 2335 6513 2113 1230 5563 3725 10000 960 2997 5507 3576 9586 8826 2632 7184 PMC7436330__F1 Red arrow shows the classical pathway of LPS-mediated activation of TLR4 that further leads to pyroptosis and releases of IL-1B and IL-18 7099 3603 10533 79792 PMC7436979__F6 Components-Targets-pathway network 1956 4846 3569 836 6352 4843 5970 596 5743 4318 3162 1906 1950 7124 5595 7422 3458 3553 7099 5594 3725 PMC7438569__F5 Cardioprotection from NAD+ repletion 10135 142 952 23411 5337 51547 847 2626 PMC7438927__F6 Canonical Pathway of ‘Actin Cytoskeleton Signaling’ in IPA with AA-specific/enhanced genes in 2147 2335 1950 6714 2885 55970 28964 2316 7204 1398 387 1793 5829 324 10458 10152 7414 2934 PMC7439917__F1 ACE2 downregulation by SARS-CoV-2 induces pericyte damage and microvascular dysfunction 1636 59272 6868 7113 PMC7443001__F4 Interactions among 38 DEGs involved in the MAPK signaling pathway 6788 2318 10125 5922 4208 2264 10912 5154 6197 4790 2260 4609 355 7157 1848 8517 208 2872 7186 1147 5532 673 8717 2005 409 PMC7443474__F2 Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential 4040 4041 324 1499 2932 23401 5970 8651 3654 7189 22992 7704 26994 PMC7444072__F5 Interaction networks of DMCs according to severe features of PE 471 136332 202374 6139 10537 9228 283455 1807 26577 4045 2520 3134 84107 7726 26047 5799 11122 3115 29102 253738 53335 723961 6788 23114 8650 1462 3481 6256 7472 6694 577 4782 8030 2261 6092 54971 197259 3880 222389 140685 353376 PMC7445810__F4 Interactions between the hypoxia inducible factor (HIF) and circadian pathways 9575 8864 1407 PMC7448569__F4 Gene expression profiles of the NF-kB signaling pathway in breast cancer 142 27040 472 29760 1610 8178 613 6850 695 8717 7186 7189 4513 3929 929 114609 1270 4803 958 4049 4050 7187 5971 114034 PMC7452966__F1 Amino acid metabolism in pluripotency regulation 10419 157739 4144 83939 29968 468 100653366 2731 PMC7456566__F3 Rhabdomyosarcoma 5154 2264 3480 5155 2064 2475 1029 5347 595 4193 4613 1019 4654 2308 PMC7457511__F9 Network analysis of DCAF subfamily genes 8816 55884 80067 26259 55070 1161 25853 80344 79016 54876 64326 1642 90379 55023 8451 1643 9410 50717 80232 7089 51514 5929 7090 79968 7088 55759 83743 54554 55234 79726 54475 170692 125061 23499 9759 10014 55600 26118 11137 64925 5931 85320 57657 163590 2932 10300 955 10238 51185 100147744 5161 55626 54014 25942 8726 55182 140801 84056 9730 79269 124801 348995 25879 2783 387103 1446 80152 8731 26263 26094 8945 23341 56 139170 340578 PMC7460598__F4 Proposed mechanism by which LOXL2 causes fibrosis and cardiac dysfunction 4017 4087 4088 2475 PMC7461028__F6 PI3K-Akt signaling pathway is downregulated in U87 glioblastoma cells overexpressing ZNF554 2475 1977 7248 7249 6009 1975 2885 672 3667 4609 5879 613 6850 5163 930 595 5728 11140 5934 572 6256 4193 9180 896 9134 7534 627 284 6199 3643 56034 4908 3909 5527 5525 7057 284217 PMC7461110__F1 Cellular Responses to Platinum-Based Anticancer Drugs and UVC: Role of p53 and Implications for Cancer Therapy 545 472 581 4193 57103 27165 PMC7464343__F2 The mechanisms and cell fate decisions’ crosstalk underlying necroptosis induction 7124 8717 7186 7188 1540 8737 23118 10454 11035 8772 197259 85451 PMC7464402__F8 Apoptosis signalling pathway and cell cycle arrest in response to Moringa extract and 3-HBI 572 637 54623 581 PMC7464644__F2 Role of Tumor-Associated Myeloid Cells in Breast Cancer 6774 6362 133 10507 383 1435 1950 8205 2919 1956 2043 PMC7465013__F5 Gene networks analysis of quercetin–resveratrol modulated genes suggest IGF1 and BCL2 as key signaling nodes associated with anti-PCa effects 4487 8204 7113 9049 858 2115 3486 3490 203068 PMC7465096__F8 “cooperativity model of MIP-1A amplification” in THP-1 monocytic cells 7099 4615 3654 7189 7186 3661 6648 PMC7465132__F2 Cell death receptor-associated signaling pathway 8772 8717 1540 7186 23118 197259 PMC7465134__F1 miRNA modulators of the p53 signaling pathway in Adrenocortical Carcinoma 4193 581 9133 842 836 PMC7465272__F1 STAT activation pathway with opportunities for inhibition 50943 920 6868 3976 2056 1956 2885 6714 2475 50507 8835 1431 9021 8651 5008 581 PMC7468867__F9 The regulatory effects of foxtail millet on the progression of colitis-associated colorectal cancer (CRC) 4280 196 50943 5111 6774 PMC7471342__F1 Top 25 mRNA-hub genes in baseline analysis 6194 6187 6175 7531 6124 5747 1445 6208 3725 3190 208 6188 3611 6224 2534 6464 6203 142 5468 83737 11059 6122 5710 10537 997 6500 6217 1956 7251 1499 2064 351 6955 7157 3320 PMC7471342__F2 Top 25 mRNA-hub genes in delta analysis 116986 1398 3717 729230 2597 1938 2243 7251 1937 1410 351 10575 348 6622 3320 3315 PMC7471511__F11 Dichotomy in gene regulatory associations during the activated B-cell to plasmablast transition 3558 59067 958 613 3662 10664 10538 6689 7494 PMC7472444__F4 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase 3099 2821 5214 230 2026 5105 3939 3945 PMC7472859__F8 The key proteins related to the PPI-PD network obtained as common proteins with the highest score through five ranking methods 7054 2099 5728 4318 2247 5290 1432 3576 7422 6622 102 3569 351 5594 213 6233 4790 7314 5599 3162 7099 551 2597 7316 154 836 6648 6647 60 2580 998 5879 7157 627 355 3630 3586 PMC7473936__F12 Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure 389 388 847 387 171177 6548 57381 1760 998 4478 5058 28964 5879 3984 5880 5881 6010 PMC7474398__F6 Distribution of target proteins of the QX1 formula on the integrated “cardiac disease-related pathway.” The cardiac disease-related pathway contained calcium, MAPK, PI3K/AKT, and Toll-like receptor signaling pathways 2778 10020 5350 4843 1129 4846 7124 3725 3553 7186 1950 1956 2885 4351 6722 3569 4609 572 596 5728 5066 6256 7097 4193 1147 3929 929 114609 7099 4615 7189 8178 23118 10454 PMC7475009__F1 Based on WGCNA, we explored the correlations among gene modules and all possible variables, with particular interest in those related to age 933 971 930 2638 10196 4067 613 6774 4485 3479 3630 PMC7476096__F3 Effects of miR-135a on cancer progression and relevant targets and signaling pathways 3206 7436 648 6093 9475 6778 11279 9788 2308 324 23035 6477 1499 3479 3717 6774 1956 57786 5789 595 PMC7479251__F6 Hippo pathway including targets and drugs that could be employed to inhibit it 4771 4485 60485 9113 26524 PMC7479313__F15 Signaling Pathways of E2Fs in Gastric Cancer (TGFB Signaling Pathway) 4583 1045 7015 2064 324 6469 51426 5914 545 596 3082 60485 PMC7479660__F4 Proposed mechanism by which losartan through Hsp70 inhibits the epithelial to mesenchymal transition (EMT) induced by angiotensin II in proximal tubule cells derived from SHR 999 367 1003 1499 387 4087 4088 PMC7481593__F1 Ferroptosis 7018 100 55240 2182 3658 2937 3156 10162 8031 2879 6520 PMC7483256__F2 Small-molecule drug repurposing to target DNA damage repair and response pathways 4436 2956 4292 5395 3978 9156 5111 7508 1643 1642 2067 7507 5426 3980 57697 91442 22909 55215 5888 80198 PMC7483256__F3 Small-molecule drug repurposing to target DNA damage repair and response pathways 7518 3981 7486 4361 3980 5426 7515 472 675 672 9156 5888 641 7517 7516 80010 PMC7484674__F6 Top 3 modules with relatively high scores from the protein-protein interaction network 3833 353189 5795 29089 9133 683 8438 9725 259266 948 55872 160364 6515 53831 719 991 4973 983 2358 3689 5337 10288 1536 199675 55355 79733 55789 2204 2207 2237 383 2919 8972 6372 4318 4057 196883 5199 5806 5368 6387 56729 126014 10874 8993 6352 3577 6590 4317 6947 7076 5004 3579 5873 2352 259287 2215 10321 1116 3934 187 PMC7484982__F4 Reign in the membrane: How common lipids govern mitochondrial function 10087 1674 56947 7417 581 PMC7486457__F8 Proposed model for the relationship between NRF2-FOCAD-FAK signaling and cysteine deprivation-induced ferroptosis 2879 231 2495 2512 54914 6117 PMC7487264__F3 Activation of the PI3-kinase/Akt pathway by VacA 5266 324 1499 595 PMC7487603__F1 Endothelial cell migration during sprouting angiogenesis 7422 91010 998 6722 2308 4920 4485 7474 7414 1495 1499 5879 PMC7492639__F1 Ozone-mediated effects on intracellular pathways involved in cell injury and inflammation 115004 9817 90865 64806 114548 6387 6347 4282 260431 PMC7497309__F2 FOXO regulation by phosphorylation 4485 5058 983 1017 PMC7498011__F5 Rps27a might act as a controller of microglia activation in triggering neurodegenerative diseases 3447 386653 4055 2208 25 3588 5553 7433 5133 54209 5724 3606 1535 1113 54472 3134 7187 3702 6714 51348 6233 3608 708 5359 7293 829 51728 5293 7314 6737 3688 3133 3716 5581 11151 245936 3604 6725 11009 9641 1813 3572 246778 2244 PMC7499294__F1 ER stress-induced apoptosis in lesional macrophages and ECs 22926 7186 83939 468 847 355 PMC7500440__F1 Pro-tumour activities of neutrophils.a) Neutrophils can express ligands of immune checkpoints expressed on T cells, such as PD-L1 4318 383 920 1950 3577 3667 3579 PMC7500861__F5 Metabolic pathway differences between LLO118 and LLO56 and identification of mGPD2 as a candidate gene 2820 56261 2618 3099 5631 5471 5214 7372 254531 55326 7371 10423 23646 375775 223 29968 5335 5277 6675 26227 132158 5230 5223 9487 5293 84532 3073 6303 138050 2027 33 31 8520 5538 2194 5315 54187 4200 55907 2678 790 5352 158 2806 6390 10402 10606 2739 1738 3419 55157 211 210 PMC7501262__F4 NLRP3 inflammasome in endothelial dysfunction 114548 3146 3553 7097 3554 3383 7412 4615 3654 51135 7189 1003 PMC7501700__F6 AD-integrated pathway and functional modules 7099 80201 3939 2023 2597 1977 2064 1950 2475 5579 759 7422 5578 1956 2885 6722 8717 5778 1843 1147 7124 3725 7186 7157 331 4513 958 7189 5970 627 126669 2549 3667 5580 801 998 581 5879 PMC7503523__F2 Polyomavirus JC: one virus, two stories 5371 3480 472 9656 545 3479 4193 4771 3667 5888 324 1499 4609 PMC7504726__F2 Antioxidant effect of quercetin on enzyme activity, signal transduction pathways and reactive oxygen species (ROS) 581 847 1958 4094 PMC7505114__F5 PAK1 cross regulate multiple signal pathways.RAS activation directly initiates PAK1, MAPK and PI3K/Akt pathway 5058 5163 1499 2475 PMC7505161__F3 Toll-like receptor 4 (TLR4) activation in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection 7099 3569 59272 PMC7506081__F4 In tumor cells, the glucose uptake is significantly increased 5209 8473 9817 2475 2308 6774 2194 6576 47 3949 PMC7507121__F2 TGFB signaling pathway 7939 5045 7048 7046 4092 4087 4088 4089 1024 1025 142 51592 PMC7511812__F7 Major molecular pathways 3553 3603 1025 PMC7517358__F3 Genetic networks associated with genes differentially expressed between radiosensitive and radioresistant gastric cancer (GC) cell lines 894 9466 3236 3046 23624 6422 9823 8507 79844 10562 51761 6285 5127 102 367 10392 9076 4110 1030 2274 3091 2273 3589 5054 8926 6286 5366 4303 7078 4015 64127 57575 55647 4193 1363 4922 3661 9235 9945 9246 972 54476 3934 943 629 2555 3399 10630 4665 1398 818 3694 1466 26191 3562 6236 5553 2051 2354 4601 2146 118429 7980 11013 3398 4354 84419 2214 3146 900 2181 3295 944 687 5796 2995 3237 10397 3172 9589 638 7090 22873 6224 4617 8942 216 10484 4084 PMC7518592__F5 Global gene expression profile under low-temperature conditions in the brain of the grass carp (Ctenopharyngodon idellus) 4597 4598 3156 3157 2222 6713 39 4047 50814 10682 1717 PMC7522539__F4 Mood stabilizers and mt protein or pathway targets, as well as the schematic of precision psychiatry medicine 23551 1432 3098 2782 1610 4958 2475 267012 4846 7124 4719 2166 203068 7384 3612 120892 2011 7431 3190 5468 8678 6204 3952 3308 1191 2931 6576 7534 5578 3725 7334 6389 2744 6135 5530 2932 1622 5211 3720 4790 638 3329 374291 836 7808 3613 3066 596 7132 2534 PMC7522543__F6 The prostate cancer pathway 1027 5925 9134 1869 4824 1870 7113 2078 7018 1871 5328 5327 4318 6935 5728 1956 2064 2260 572 5154 5266 2263 2308 5155 56034 468 80310 5156 1385 7039 5159 4193 10488 208 2885 90993 2033 2932 10000 595 1499 1147 6932 6655 4792 369 3551 5604 673 5605 6716 83439 3265 8517 4790 6934 596 3845 5970 2475 367 354 3320 3326 7184 898 842 5290 5291 2119 5293 1026 1387 64764 6654 PMC7522985__F1 Biosynthesis and Metabolism of n-6 PUFAs and LC-PUFAs 95 11343 4099 9415 2717 3992 2182 2180 51703 79143 10162 100 4513 4512 717 5730 4056 9536 26136 4048 246 5740 6916 PMC7523373__F1 Structure of Bruton’s tyrosine kinase (BTK) and associated cross-linking signaling pathways 7054 613 695 6850 4067 29760 10892 PMC7526653__F1 2HG metabolic pathway 3939 3418 3417 PMC7530268__F1 Ferroptotic cascade 2937 875 2879 8031 9817 2495 2512 23657 4015 2182 55847 PMC7530326__F2 Dysregulation of TGFB/BMP signaling in CCM 7099 929 4089 654 10365 9314 960 PMC7531772__F5 Genome of the Softshell Clam Mya arenaria and the Evolution of Apoptosis 8772 7186 100506742 3002 355 841 1616 83939 843 790 8717 468 637 835 842 581 9049 56616 27429 2021 572 472 4803 5163 3265 8739 PMC7532093__F8 Protein-protein interaction network of hsa-miR-30a-5p-related DEGs 167227 58495 9749 2139 79977 1119 51804 91694 144455 9134 1837 1756 3131 7431 54790 1073 4684 9545 2628 4094 2731 57605 7077 2535 2534 8434 3716 596 6095 7780 10942 2241 79102 1909 80315 10659 PMC7532093__F9 Protein-protein interaction network 10228 10652 2069 288 4905 4300 90411 70 55588 8243 6426 2288 342184 9117 55737 4297 5981 7414 1164 11201 2241 9219 836 8626 23057 5073 55167 6387 83464 3939 26984 85464 5324 PMC7533893__F2 Classical KEAP1/NRF2 signaling pathway 8452 2729 2730 2877 140809 7296 5226 3417 4199 9817 3162 PMC7533893__F6 NRF2 in regulation of cancer cell metabolism 1036 26227 7358 4199 4118 355 11113 3417 4144 PMC7537941__F2 Activation of the coagulation cascade and endogenous anticoagulants 7035 7124 7018 5340 324 PMC7538181__F1 Transcriptional regulation of memory B cell differentiation 3566 50615 958 613 4067 6850 6774 6778 3394 100271849 4208 3399 3662 604 4609 1869 894 896 6929 6925 2146 6504 1026 1029 1027 PMC7539814__F6 Schematic diagram for blockade of autophagy in stable MED12-mut UtSM clone 9968 2475 847 PMC7541099__F2 Therapeutics under clinical trials targeting the cytokine storm in SARS-CoV-2 infection 6868 59272 4615 9242 9021 4117 6774 4318 999 1401 7173 718 PMC7541127__F4 Landscape of major pathway alterations in primary GBM 1956 5156 5728 4763 673 4193 1029 1030 1031 4194 7157 1019 1021 5925 PMC7541823__F1 Receptors implicated in the internalisation of Mycobacterium sp 7097 948 8685 1378 929 8178 7098 54106 324 114548 64127 9447 3428 PMC7542157__F2 Molecular mechanisms of NADPH homeostasis in cancer 2539 1719 5226 10840 4522 4199 10797 4190 441024 10873 4200 2805 3417 3418 2806 23530 27165 PMC7545020__F4 An aberrant STAT pathway is central to COVID-19 7099 6774 1401 10401 3037 7939 6772 PMC7545792__F8 Map of Th17 cell signature cytokines and the IL-17 signaling transduction pathway 84818 7187 132014 55540 29110 29761 7186 8717 23118 8772 2919 2920 2921 3627 6347 6354 6364 3458 6361 100289462 6356 6280 3934 4312 4322 PMC7547615__F1 Pathogenesis and immunomodulation of COVID -19: 1 59272 3661 9973 90865 3627 PMC7547615__F3 Mode of action of MSC's for treating COVID-19: 1.Ifusion of MSC's 2 9242 3082 1950 59272 664 PMC7550684__F1 Signaling pathway of Interleukin-17A (IL-17A) 7186 7188 10865 7189 PMC7551201__F2 RAGE signaling pathway 7099 4087 4088 4615 4089 998 5879 2475 1499 688 6275 6662 4193 3569 3552 6354 57181 80149 3934 5168 1950 383 596 8434 23411 4313 6667 4318 PMC7551201__F5 S100A8/A9 provides a premetastatic environment 6279 6280 7099 4087 4088 2919 4089 6354 57181 3934 80149 5168 383 3586 PMC7553088__F4 Chemokine-like factor 1: A promising therapeutic target in human diseases 1233 7412 3383 207 581 PMC7554303__F3 Immunometabolic and bioenergetic changes in a macrophage infected with Mycobacterium tuberculosis 56947 790 717 7097 4615 948 4513 6778 2625 3716 3718 3565 3596 4283 3627 PMC7554583__F1 Mitochondrial stress responses in cystic fibrosis 65018 22809 596 581 8192 54623 PMC7555177__F4 Protein–protein interaction networks of the encoded proteins of the consistent DEGs that participate in sphingolipid signaling pathway (hsa04071) and sphingolipid metabolism (hsa00600) 10558 9517 55331 5600 2581 81537 8503 5337 5581 5578 57704 207 5293 208 9294 2768 5338 9475 6609 8439 8877 1509 5295 6093 5590 23236 5728 5594 5296 637 55012 6610 7157 2534 427 5170 10000 624 5604 7357 64781 5527 5526 2720 5520 5522 2717 5881 2206 8879 5291 5290 259230 123099 596 5894 55627 3265 581 5516 PMC7555177__F5 Sphingolipid signaling pathway and sphingolipid metabolism 1903 8698 624 1901 2534 7124 5295 2771 9846 5296 2768 2767 8439 2720 6010 57704 7357 9475 8877 81537 5728 5578 5604 208 64781 55331 9350 5590 1509 637 2581 581 PMC7555769__F3 SMO in cancer 6608 4313 4318 652 10983 6010 920 596 PMC7555774__F3 Inhibitory signaling events against AngII/AT1R-mediated senescence in VSMC 9474 23410 23411 PMC7556532__F8 HER2-mediated enhancement of Ebola virus entry 7301 8205 207 2621 558 10461 PMC7559203__F1 an overview of virus-deregulated NFKB signaling pathway in oncogenesis 9365 596 3397 5971 PMC7559203__F2 EBV-deregulated NFKB signaling pathway in oncogenesis 6850 4067 2638 4089 27040 637 PMC7559222__F7 SNORA71A/mRNA/pathway interaction network constructed and visualized by Cytoscape software 3952 3929 64102 56246 8836 3043 6227 2038 212 6208 6626 276 PMC7559280__F3 Epigenetic modifications in the livers of male young adult IUGR-N mice 2158 26524 5105 126374 5045 10155 2906 229 4783 149111 90249 22887 9575 163589 4756 10472 51466 2781 1977 213 55740 9568 7423 59345 79799 8570 2788 5962 81029 51592 207 7976 133688 84133 4041 4087 1869 5291 9846 55775 1459 7291 3482 6416 23429 85440 10818 91 5879 5925 10188 6929 121536 613 28964 10787 91584 1788 8289 391 84708 6478 376267 64283 10477 6996 51560 10501 51465 57520 135293 PMC7562735__F10 Distribution of targets of KGEC on the comprehensive signaling pathway 2885 2475 10110 6446 572 6850 7124 596 3558 1019 27040 613 638 7412 7099 4513 3934 4314 7186 4318 8717 8772 PMC7563548__F11 Partial of the NRF2-mediated Oxidative Stress Response pathway in Fayoumi birds with acute heat stress 3725 152831 2729 5291 5293 23317 54431 873 60 2936 2260 4189 23551 9097 7314 72 2353 5447 55466 PMC7563597__F2 Molecular mechanism of extrinsic and intrinsic pathway involved in apoptosis 7124 572 637 90427 8772 8717 150365 581 331 PMC7564943__F3 AhR activation contributes to alterations in mitochondrial metabolism as does suppressed pineal melatonin 15 438 5132 196 406 7808 6648 4513 PMC7564943__F6 AhR-induced cyclooxygenase (COX) 2/PGE2/EP4 has differential effects in anti-viral cells vs 196 406 5132 4513 PMC7565308__F5 Systems biology analysis 26136 226 2887 847 217 1312 2934 301 58477 23011 4072 1072 5901 27434 7431 4843 311 4000 836 2194 5315 26509 7037 10971 4627 7052 7414 9349 3303 7163 27044 2224 5471 10963 7157 PMC7565308__F6 Global subnetwork analyses 7124 973 6850 4067 7187 5336 695 407975 5728 27250 8915 5579 84433 7189 2475 6194 7128 11124 4792 4609 8837 1977 596 331 8772 332 843 598 841 581 637 367 3320 2289 2908 5594 3569 PMC7565380__F3 Most important ncRNAs that regulate ER and HER2 receptors, drug efflux, apoptosis, DDR, cell cycle arrest, EMT, and CSCs features in BC drug resistance 257000 693215 283131 400500 100124700 960 2064 3480 1956 5728 693223 652995 6117 672 2475 898 693198 51755 595 999 100126316 1018 79923 100126348 1869 1499 572 104472715 101805488 6935 9839 664 7565 100302155 100507632 PMC7565446__F3 Thyroid hormone synthesis pathway (modified from hsa04918) 107 8458 7276 109 196883 7054 112 5566 2778 113 5567 7253 115 7252 2776 23236 1385 5330 5579 5332 7038 468 3309 821 1388 3709 7184 9601 3710 433 5172 7173 389434 50506 405753 213 2936 2879 4036 PMC7565554__F2 Transcription factors downstream of TORC1, input linked to their action and cellular processes affected 4553 64798 2475 64223 468 7942 PMC7565722__F6 TRAIL of oncogenes to apoptosis 140823 581 6098 PMC7565831__F3 Amino acid sensing by mTORC1 652968 6009 153129 375 PMC7566900__F2 BMAs-derived adipocytokines regulate behavior of metastatic breast cancer cells in the bone marrow 3603 387 7099 10487 1240 2167 PMC7572679__F2 Metformin modulates lipid metabolism in the intestine, liver, and adipose tissue 2932 1499 6932 4099 7038 355 56947 PMC7573103__F3 Signaling pathways in TNBC targeted by multiple components of the MD oils 4040 4041 2932 324 2475 4513 847 595 PMC7577645__F2 TNFA and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis 7124 8717 7186 27035 5879 55312 10811 8411 PMC7581770__F1a Systems analysis of avascular necrosis of femoral head using integrative data analysis and literature mining delineates pathways associated with disease 3486 654 4524 847 4133 4318 338 7422 7048 3791 7049 8600 7018 1380 302 353 7424 4313 PMC7581770__F2 Pathway annotation analysis of AVNFH patient cartilage transcriptomics and RANKL induced osteoclastogenesis transcriptomics 867 8029 4522 5644 27249 4524 113235 81693 5826 25974 166785 55788 200895 1719 4363 55163 440387 25902 10797 6948 11330 81034 316 84245 4837 1491 875 7172 1312 84890 23446 9446 2730 58478 51504 55256 4397 5609 7185 998 23118 4286 5879 2353 5747 7037 5604 208 5608 8600 57192 7186 4067 2475 9060 4792 10312 799 1513 2274 5296 5971 PMC7582185__F4 Transcription factor CREB1 exhibits an opposite regulation in the downstream genes between WT and VCP TG mice in response to 2W TAC 7415 7038 130574 257068 5972 386618 797 3491 5617 3952 340419 407738 3623 4583 51083 3553 255631 2915 2669 84879 6870 4826 9381 2898 1134 3122 3105 57084 1008 1496 3358 5409 3248 57221 2571 6611 23237 1264 9592 2572 114786 118027463 1843 25976 124961 22986 50943 340533 2353 23635 4609 9314 1052 90007 1959 3725 4288 81575 PMC7582192__F5 Targeting N-myristoylation for therapy of B-cell lymphomas 613 973 974 375 6850 PMC7585053__F3 Graphical representation of the five candidate pathways and their significantly contributing genes 5160 586 9451 57176 5499 23395 161 5162 2932 587 55699 1983 1759 6456 160 1211 1175 1173 8636 1213 7532 7283 4803 5518 5347 1639 8655 80321 5566 22919 9329 54820 2976 6420 4957 55814 2972 1069 5437 80254 5116 203068 4751 6908 5434 10733 7531 55703 9330 PMC7585454__F3 Myocardial Phosphodiesterases and their Role in cGMP Regulation 8654 7248 7249 25801 5152 5997 7222 7225 PMC7586293__F2 |Central metabolic pathways are driven not only by post-transcriptional changes but also by the adaptation of protein concentration upon the induction of insulin resistance 10580 10603 5770 355 31 6009 50 2932 2271 2297 2475 57521 4967 PMC7586489__F4 Crosstalk between BER and MMR promotes TNR expansions and suppresses TNR deletions 5423 7143 2237 4968 PMC7587305__F3 XRCC1 participates in BER by facilitating transfer of DNA damage 7515 3980 5423 142 PMC7587305__F5 XRCC1-APLF – an interaction between two DNA scaffolds 11284 54840 5423 7515 3980 200558 7518 3981 PMC7590567__F1 Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors 8772 637 3550 572 90427 8739 638 4170 5728 8717 7186 PMC7590591__F7 Pathway of anti-tumor activity of plumbagin in bladder cancer 1499 4318 4193 2932 2475 595 1017 1019 898 1021 581 PMC7590703__F1 Functional and cell number defects in NK cells caused by different PIDs 7454 2624 51750 3394 3561 100 5873 2274 1130 5551 PMC7592369__F4 Role of HIFA on fatty acids metabolism during cancer progression via epigenetic regulation 355 5728 1431 3418 PMC7593653__F5 Diabetes-induced cardiac UPS dysfunction 3667 5465 2626 64326 8452 2308 4094 9817 PMC7593681__F9 Potential mechanism of HBO treatment on intestinal barrier after SCI 6010 6093 999 PMC7594557__F11 Simplified overview of signaling from common types of DNA damage to the DDR and cell cycle checkpoint pathways 6741 4361 10111 3014 11073 672 84126 675 5888 472 545 993 1869 1021 1019 1017 983 PMC7596222__F4 Molecular pathways triggered by eCSF-derived factors 1499 4090 4086 2549 324 10818 4040 5727 6608 6469 2247 1950 627 PMC7598617__F4 IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis 50943 2475 6774 7421 3569 5212 114548 PMC7600397__F4 DNA damage response pathway (DDR) 10111 3014 672 7515 5423 472 545 7465 PMC7601265__F7 Illustration of hypothetical antioxidant mechanism for peptide MS15 against oxidative stress 9817 6647 6648 847 2876 4094 PMC7601352__F2 Screening of key genes related to the prognosis of mouse sepsis 7040 83706 3674 3676 824 29780 7041 1495 71 7170 57580 5585 7532 5788 81 7791 8844 221178 1265 4194 3932 1794 9047 3551 8440 9046 10133 7535 29924 10477 3702 6233 3725 919 2113 2353 56957 6688 4778 84196 6772 5371 2623 6886 3459 161882 PMC7601745__F4a Indoxyl Sulfate-Mediated Metabolic Alteration of Transcriptome Signatures in Monocytes of Patients with End-Stage Renal Disease (ESRD) 2153 56975 11326 55884 3685 199675 718 9306 5226 5724 1230 2936 2539 7706 3576 2268 80270 5447 7408 7124 2203 51099 6868 3340 5694 2239 10162 64131 PMC7602422__F1 Aryl-hydrocarbon Receptor (AhR) Signaling Pathway in Osteoclasts 196 405 1544 6850 4772 PMC7603127__F2 NRF2 directs numerous metabolic processes that impact cancer cell survival and proliferation, including NADPH production and the metabolism of lipids, amino acids, nucleotides, and iron/heme (a) 4199 3417 2539 26227 355 5226 29968 6888 7086 5471 10797 6472 6470 2235 3162 7295 7296 2729 2730 2879 2936 2744 440 PMC7603577__F7 IL-17 signaling pathway of plantain in the treatment of gout and hyperuricemia 8717 8772 7189 55540 23118 257397 4513 84818 4318 2932 10763 132014 PMC7604390__F1 Model showing intracellular lipid metabolism and AA metabolism in ovarian cancer 4018 3949 948 2194 47 4513 23152 2171 PMC7604396__F1 KRAS4B domain organization and RAS signaling pathway at the cell membrane 3845 7431 6654 2885 1950 1956 PMC7605384__F6 Network of the tRF-mRNA-pathway constructed with 7 selected tRFs (5 were upregulated and, 2 were downregulated) and their target gene 10803 5778 6722 59283 23500 107 782 2261 2317 57551 1848 1524 1845 1857 5058 6375 5606 56998 5578 10681 81839 10297 4776 6789 6774 7976 1849 22808 81579 4208 2260 10454 818 10368 7046 5331 5528 5970 51764 2870 23236 111 2782 64840 777 6654 5159 5568 93589 5567 5566 1844 59284 5530 5923 627 643 8649 6376 23002 1387 5590 57216 10451 2239 166336 2833 6367 5829 5062 PMC7605689__F2 netboxr: Automated discovery of biological process modules by network analysis in R 1029 10576 6872 1030 908 1019 4193 4194 1031 5789 894 6908 3303 6619 5791 5925 57122 54796 10762 1316 6635 2042 5292 10677 116986 5728 10540 5787 7010 1398 5290 3791 1793 5295 8777 2549 10818 3815 246329 2 5781 4069 1956 867 10253 3717 5287 5465 2064 3458 3122 3454 3467 6456 6900 8074 3456 4684 3439 3440 PMC7606733__F5 Enrichment of the Hippo signaling pathway in CCA 10207 154796 23513 166824 374 174 3689 4092 3397 3398 8313 1499 4609 324 PMC7609422__F1 Core proteins involved in the autophagy pathway and its regulation in zebrafish, knockout (KO) zebrafish lines highlighted in red, and boxes show commonly used drugs which can activate (green) or inhibit (red) autophagy activity 57724 83985 2475 8408 3920 60673 9776 55626 9140 55332 9474 10533 64422 10133 PMC7641543__F1 EMT transcription factors by Wnt/GSK3B/Beta-catenin/Snail and PI3K/AKT/GSK3B/Snail signaling 1950 1956 3667 2932 324 1499 PMC7641965__F3 Integrating immunotherapy and targeted therapy in cancer treatment: mechanistic insights and clinical implications 8205 4609 961 5728 6774 6955 2921 3845 6351 1499 3579 1956 6352 6354 6346 3627 PMC7642822__F8 Regulator effect networks generated by Ingenuity Pathway Analysis (IPA) in MCF7 over-expressed mitochondrial fission factor (MFF) 595 3880 3688 890 5925 6117 6840 118 5604 4582 5829 55742 9475 7514 27250 4792 581 387 929 7298 1191 2194 PMC7642974__F1 Action and classification of E3 ubiquitin ligases causing neurological diseases in human 10075 83737 57531 23327 57520 8925 9320 8924 89910 81790 90678 54476 7187 4281 84231 11043 23321 9978 8454 6500 5192 22954 899 79791 55521 23194 54941 55823 165918 25793 23291 6921 8452 80311 136371 55975 23221 6015 1642 51185 5903 8450 10210 50717 PMC7642974__F9 The autophagy pathway by E3 ubiquitin ligases 51185 7189 55823 54476 9140 55626 9474 26100 10133 8408 60673 9776 10075 22954 23327 8924 65018 8031 64798 23291 7942 90678 PMC7643020__F3 Crosstalk between autophagy and apoptosis 8717 64422 56616 27429 9474 PMC7643190__F1 Biomarkers, molecular pathways, existing and emerging therapeutic targets in colorectal cancer 1950 1956 3845 1499 673 324 2475 PMC7645337__F7 Core molecular net words identified by IPA 2056 3099 5476 3172 3162 405 3725 3091 PMC7647673__F2 Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics 4553 27161 6117 3714 192670 192669 PMC7647682__F3 Putative molecular mechanisms and signaling pathways that may regulate the endothelial-to-mesenchymal transition (EndoMT) process in systemic sclerosis 4089 4087 4088 1499 1003 PMC7648344__F1 Activation of MET pathway: pleiotropic effects on cancers through activation of a number of signaling pathways 3082 2885 2549 6774 6714 2475 572 4193 PMC7653260__F4 Signalling pathway of programmed necrosis in hearing loss 7124 8717 8772 197259 PMC7653868__F1 Reactome FI network 6392 10131 47 5210 9590 29072 4306 8994 2033 9113 58484 5610 6586 2273 990 5914 7074 6478 2099 23365 8841 9886 4804 26575 4485 5335 1523 27436 6801 238 7316 54882 3837 4904 9768 57448 1655 26994 7416 2118 4836 3725 6667 3265 2534 4478 6464 6281 387 5747 55193 23604 5580 405 672 8648 2520 10642 7058 4291 64132 4134 8314 PMC7653868__F2 Yellow nodes represent genes enriched in Infiltrating Ductal carcinoma of breast identified by Pathway enrichment 26575 7058 6586 8314 23604 23365 6717 6478 8841 6801 9886 607 27125 6281 5210 9590 47 990 27436 238 6774 4804 23092 9768 26994 7416 4836 8821 4478 387 25937 55193 84687 55558 2520 8030 64132 10131 6392 10642 PMC7653868__F3 Pathway in FI sub-network 23092 23365 4478 387 4804 6464 5580 6478 58484 5610 6774 8841 8994 5914 25937 9113 672 8648 29072 8314 2118 405 PMC7654218__F6 Effects of extracellular antagonists in the Wnt/Beta-cat signaling pathway during the proliferation and differentiation in human osteoblast 27121 6423 27122 4040 4041 324 PMC7655645__F3 Protein interactions associated with signaling pathways enriched in diabetes mellitus-associated coronary heart disease 8722 8320 2744 23386 196513 23203 6242 1521 1605 55929 1844 10980 23704 4818 57595 83759 84336 5116 84058 2793 55038 27087 2999 138428 79156 4931 64708 79683 114904 7629 26056 808 8871 25814 283989 79037 25839 9254 114836 203260 7535 9118 2778 637 PMC7656123__F3 Identification of an important regulatory role for miR-574-3p-mediated signaling pathways (especially the EGFR/RAC1 pathway) in spinal chordoma by integrated analysis of both the miRNA-mRNA and protein-protein interaction networks data 23608 8453 4734 408 5029 84251 7421 338 1213 4089 1956 6256 3662 3092 1759 8976 5879 604 1003 7145 5599 8829 9075 255324 102 1839 PMC7656585__F2 CP-25 on cells and possible mechanisms 941 958 9308 942 930 939 3553 7054 383 780904 10563 6387 7852 643 156 7186 4397 65057 PMC7657662__F4 Schematic depicting the complex III assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded subunits underlined and assembly factors in italics 7385 7384 2242 90624 7386 717 617 7381 7388 29796 10975 54902 27089 55245 84300 790955 1537 PMC7657662__F5 Schematic depicting the complex IV assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded proteins underlined and assembly factors in italics 10063 388753 51241 9997 1350 1351 1352 1353 90639 1355 192286 9377 1329 4512 4513 1349 4514 51204 55744 28958 152100 116228 25994 84987 285521 6834 1345 4697 100131801 100303755 80775 PMC7658242__F8 IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling 468 140805 10533 PMC7658690__F7 Relationship between target and pathway network 8517 207 7097 5970 5743 7124 2353 4318 3725 1956 2932 4312 PMC7659517__F1 Warburg effect likely supports replication of SARS CoV2 in airway cells.Enhanced aerobic glycolysis sustains the replication of many viruses in a similar way to the Warburg effect 59272 47 5163 3939 2717 PMC7660678__F1 Pathway for the endogenous synthesis of arginine 162417 1356 4942 384 383 PMC7663720__F1 Wnt signaling pathway 4040 4041 4920 4919 324 1499 6010 998 607 3725 1386 PMC7668240__F3 Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation 31 3991 6605 3326 5422 7052 5864 5933 196 1356 5567 22843 216 6597 11200 4176 5208 1027 1019 1719 1017 135112 781 6622 4129 6812 2643 2194 5058 1191 2638 22800 816 10814 2243 9066 4023 348 7200 5865 23705 335 1947 57586 5140 6813 6844 3312 5313 PMC7674124__F1 Expression of PROK1 (A) and PROK2 (B) 3091 84432 9575 60675 57057 PMC7674641__F1 Metabolic pathways connected to protein prenylation 55902 47 4397 3417 3156 191 23463 3652 9986 387 PMC7686704__F1 Canonical Wnt signaling pathway in mammals 147111 50964 999 3487 54894 4040 4041 84133 8549 1499 324 8658 5879 6477 607 PMC7689298__F10 Proposed model of the involvement of TREM2 in the IL-4-induced anti-inflammatory response 54209 3718 7099 4615 6778 162 383 1436 712 3479 199 64581 3687 7124 PMC7689704__F8 Pipoxolan suppresses the inflammatory factors of NF‐KB, AP‐1, and STATs, but activates the antioxidative factor Nrf2 in LPS‐stimulated RAW 264.7 murine macrophage cells 3929 929 7099 114609 4615 3716 3717 6772 6774 2353 847 PMC7690754__F17 Pathways involved in BCC pathogenesis 6608 5727 51684 64399 1950 4851 55872 9113 26524 847 PMC7692234__F4 Hypothetical host-cell signaling pathways linking Cryptosporidium parvum infection and tumorigenesis 324 8826 1499 PMC7693003__F2 Role of FDFT1 in the biosynthesis of cholesterol, structure and roles of lipid rafts and regulation of FDFT1 by SREBP2 2821 3156 22937 2222 PMC7693799__F7 Molecular enrichment networks of genes associated with diabesity and the cluster 3 network enrichment analysis 5286 7012 1520 1956 567 6233 4317 4318 6464 3567 3636 7077 5590 3667 3630 3643 3949 PMC7693814__F5 Illustration describing inflammation and apoptosis mechanisms in SARS-CoV-2 infection, suggesting similarity with those in Parkinson’s disease under oxidative stress 59272 7297 6774 637 6772 54625 7113 8772 PMC7693908__F1 Oxygen sensing mechanisms 7428 5999 5927 7403 84890 PMC7694276__F2 NcRNA involvement in thyroid cancer-related signaling pathways 7503 101805492 10000 2064 7428 2475 8754 8420 3099 58191 2247 1499 595 1112 1000 286205 100886964 PMC7695361__F7 Mechanism diagram of the KEGG pathway 25805 4040 4041 894 154075 331 5970 4616 7185 4803 3553 4513 7412 5933 1874 4089 4088 1021 1019 3065 1869 PMC7697104__F1 Coupling of glucose metabolism with insulin secretion in pancreatic Beta-cell 948 2864 5163 10166 5164 5106 25874 51660 8604 10165 2747 4967 7351 83733 6576 4191 79751 2271 6391 123096 284439 PMC7697260__F3 Differences between the ECM− and ID+ fibroblast clusters are largely replicated in PDF and JDF spheroids, with distinct features present in PDF fibroblasts 64146 4792 5159 8767 5970 7184 1281 3910 3569 3688 1291 4712 4513 4697 4728 60 4311 3576 960 4708 10975 1634 3624 3552 3976 1440 4725 4726 4718 4709 4537 516 3397 3399 3400 292 PMC7697665__F4 Role of RNF11 in the NFKB signaling pathway 8772 8717 7187 7706 26994 3661 29110 257397 23118 8887 7189 7186 3656 3654 51135 4615 PMC7697684__F5 Major steps of glycolysis and direct and indirect regulation of glycolytic enzymes (in light blue) via Akt 7086 3099 65220 5208 2597 5230 55276 5223 2023 3939 PMC7697684__F8 New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance 47 142 10038 55658 472 27338 545 9097 5927 672 5888 7515 PMC7697769__F4a Gene Expression Signatures in AML-12 Hepatocyte Cells upon Dengue virus Infection and Acetaminophen Treatment 6895 7098 3458 7097 7099 114609 7297 7189 23118 7186 7187 847 4793 3661 3725 3659 1386 PMC7699575__F2 Glutathione (GSH) biosynthesis pathway 2879 23657 6520 PMC7702235__F2 miR regulatory mechanisms in experimental VCID 23621 1020 406971 2932 6326 6804 6857 6616 6844 PMC7704135__F5 Neuroactive ligand-receptor interaction signaling pathway 2896 51738 10911 799 545 174 5724 140805 5367 7054 8620 4852 3972 5741 100506013 1611 6343 7432 2690 3952 6865 51083 6870 5617 PMC7706002__F2 DEGs PPI network complex 81493 55740 115908 26973 4257 2318 4920 10276 22795 10769 81792 10393 391059 337876 83604 2247 9447 3082 54498 3075 2152 7422 8728 51062 2635 5723 2150 1368 4935 9760 26191 6498 255928 22808 3778 8935 633 860 5592 1277 1634 10631 2353 1906 PMC7706141__F8 PPI network of all DKKs and their similar genes 9754 9411 2152 57381 9079 11093 2 358 55742 351 1012 161198 813 11098 6935 7200 3912 2701 187 3909 27123 27121 4323 649 977 5741 27120 7010 51705 22943 55646 10516 26281 374 27122 79090 64840 51330 PMC7706714__F3 Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities 6774 182 860 999 1000 4318 4323 PMC7709111__F5 Three top-scoring interaction networks of highly abundant aqueous humor proteins 3700 2243 5005 3827 2161 3273 197 5265 7448 5549 710 5004 3263 2638 5444 5345 3240 3026 259 718 5176 3053 336 347 3426 732 324 337 462 717 183 5950 350 1 731 727 735 2147 3075 730 733 2153 729 3339 721 720 26998 5649 686 7316 116844 7045 2202 2335 26254 2192 4313 3488 5118 5340 629 6678 7857 3698 6696 7425 1114 7123 10577 2 1471 4060 173 29106 10418 8404 50863 1605 5621 4045 351 375790 1113 257194 334 4653 1508 3538 3489 3934 3485 3490 2878 3514 4069 1675 7076 5949 5660 8857 2934 3039 3040 563 4036 567 3501 933 4924 3043 3849 218 3858 3848 5730 60 3857 1509 51596 2950 PMC7710892__F3 The CoQ10 biosynthesis pathway 23590 57107 51805 27235 10229 51004 57017 56997 84274 79934 PMC7716795__F1 Host genetics and infectious disease: new tools, insights and translational opportunities 7097 7096 10333 114609 4615 1283 3661 3665 3656 3654 29110 7706 7189 57506 3454 3455 3716 7297 23118 10454 10379 6772 6773 11035 3717 3459 920 5994 8625 5993 4261 84888 6891 6890 PMC7717626__F1 Identity and the heterogeneity of extracellular vesicles and exosomes 4827 9156 967 928 975 PMC7718081__F8 Chronic ethanol exposure on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats 847 627 23237 3146 PMC7718646__F1 miRNA-23a can enhance the metastasis and invasion of OS cells by upregulating the signal expression of PTEN signaling pathway 1950 1956 5728 90826 2475 572 84133 PMC7725584__F2 Active compound-potential target network 2752 210 3938 2475 5595 208 2355 6648 50507 3481 177 596 4988 2194 5328 1129 1132 2159 2147 6401 1021 4313 3569 43 5468 3550 1154 649024 367 7422 279 2353 5970 5580 3725 4843 5743 4069 5581 638 4129 6256 2670 5241 890 4128 6403 8648 4306 10499 PMC7725656__F2 Diverse ubiquitin codes in the regulation of inflammatory signaling 7124 7186 8717 8737 1540 23118 81858 90268 9825 5970 1386 PMC7725906__F6 Action mechanism diagram of MXSG 23065 59272 7249 7248 5163 6009 2475 1975 7097 7099 4615 7098 51284 51135 3654 8772 6772 7189 841 3661 3659 3665 3553 PMC7726415__F1 Major metabolism pathways by Nrf2 2539 7086 6888 2194 4199 5226 645 644 948 3162 2235 2512 3417 2495 2729 2730 2879 PMC7729585__F2 Fatty acid metabolism, glycolysis, and tricarboxylic acid cycle (TCA) cycle 6513 5538 81616 2542 1376 229 5166 5163 5165 5164 5132 4200 27349 3417 6391 PMC7730291__F1 Wnt–FAK signaling crosstalks and inhibitors 324 6714 2885 64840 4040 4041 PMC7730500__F1 Schematic diagram illustrating the steps and enzymes involved in the base excision repair (BER) pathway 7536 4350 6996 23583 4968 8930 4595 79661 252969 55247 7515 11284 641 5111 2237 10038 142 8505 55775 7486 3978 PMC7736467__F6 Cannabinoid signaling pathways affecting neuronal extension length 387 6774 6714 672 5080 PMC7737552__F1 Huaier induces apoptosis by upregulating p53 expression 5728 92140 5163 2932 2475 1499 2146 PMC7748976__F1 Interaction of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus with the renin-angiotensin system and phagocyte activation cascade 7124 1636 59272 PMC7751760__F5 Cellular pathways regulated by H2S in renal diseases 4118 4615 4087 4088 7187 7189 4089 2308 23118 257397 8195 3661 2534 PMC7753217__F2 IFITM3’s mode of action in cancer 10410 6774 6773 6772 1499 4087 4088 5163 4089 2475 9314 10320 407021 PMC7753287__F2 Diverse roles of long non‐coding RNAs in viral diseases 7099 51284 5970 7097 51311 4615 4513 3454 7297 10018 3455 23512 2146 8726 7124 102659353 1435 3627 7099 51284 7097 51311 7124 3455 3454 7297 4513 23512 102659353 2146 8726 10018 1435 3627 5970 PMC7753942__F2 Summary of immunopathogenesis in early and late SARS-CoV-2 infections 59272 920 3716 3717 7297 6773 10379 57506 3661 PMC7755949__F3 Ubiquitin System and A20: Implications in Health and Disease 8717 7186 23118 10454 1540 257397 8915 7189 PMC7756113__F3 Mechanism of autophagy 2475 8678 9474 8878 PMC7757025__F3 Signal transduction of BII spectrin in tumor 3569 7099 4040 4041 4088 406937 2932 1499 324 10643 79923 10413 4092 6774 4089 4087 2177 4072 3280 1019 999 PMC7758413__F5 Gene function network revealed a core role of the AP-1 linked signaling pathways during the recovery of COVID-19 7124 114034 6418 5295 3725 3458 3320 6095 7852 2920 3579 3576 1230 3577 9021 3091 8651 5159 PMC7759095__F4 SARS-CoV-2 infection and signaling pathways as potential targets for treatment 1636 7113 59272 PMC7759159__F1 NFKB activation is central to the acute respiratory RNA virus-induced cytokine storm 59272 7099 4615 7113 8717 51135 695 7098 51311 51284 3665 7412 PMC7759481__F1 Induction of IFNs and the antiviral state they exhibit in bat (P 7297 3716 57506 4615 6772 6773 7187 4938 29110 9636 3665 3661 6041 6035 1386 3725 PMC7761891__F3 Effects of extracellular nutrients on mitochondria could activate the integrated stress response (ISR) pathway in cancer 83939 115209 468 9812 PMC7763461__F1 Toll-like receptor (TLR) signaling pathways 7096 7097 10333 7100 7099 51311 51284 7098 54106 51135 3654 3656 7189 4615 23118 7187 10454 3665 3661 3553 PMC7764417__F2 Putative model for the development of (cardiac) lipid-induced insulin resistance 948 208 3667 PMC7765227__F2 Role of the inflammation-associated transcription factor signaling pathway (NFKB) and mitogen-activated protein kinase (MAPK) pathways in the inflammatory response 4615 3553 7189 7412 3383 PMC7766288__F2 Mechanisms of several lncRNAs in CC 378938 55384 285987 100642175 2475 6935 100124700 5820 2146 643911 1499 101669762 283120 7503 5728 5111 PMC7766597__F1 Four different types of regulated cell death 8717 197259 355 637 23118 581 22861 114548 5548 9447 2879 PMC7766727__F3 PI3K/AKT signaling pathway with plant-based inhibitors (created by BioRender.com) 355 4040 4041 8772 5728 324 1499 572 7249 7248 6009 PMC7766831__F5 Proposed model of the molecular and cellular responses to new replication stress inhibitors 6741 545 142 PMC7767525__F2 Major mechanisms of double-strand break repair 142 78996 9156 56941 55215 2177 5426 5888 PMC7767993__F4 Key connectors of (A) T1D-bacterial infection in Wnt signaling pathway and (B) T2D-obesity in appendage morphogenesis 5693 5686 6500 5688 3066 5701 5970 5692 7311 5689 65125 5694 5717 7314 10213 7532 5707 6386 5216 5706 5710 5687 351 3312 604 5690 3725 4343 1654 5714 4790 5499 1213 408 7533 5494 7415 5660 7534 7316 5708 8724 11047 5713 5685 7277 9861 1956 5682 3303 1173 5709 5684 5691 5595 7088 51176 3146 4609 2908 23650 6722 2335 1958 1616 805 5566 1499 6925 4654 207 808 4760 8543 PMC7769460__F6 The MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer 4149 7099 81697 868 1839 1398 23097 4322 6868 659 960 147372 3918 4072 3157 3638 6319 8763 991 64105 9928 90417 10403 3815 375033 374 5329 26648 638 7029 4975 7054 PMC7770493__F1 Plasma membrane and primary cilium cAMP signalosomes 23432 9118 9368 1080 5108 152110 3784 5143 9495 10142 PMC7770493__F2 Mitochondrial cAMP signalosomes 572 8165 6770 54927 6714 706 5141 10651 10981 PMC7770493__F3 cAMP signalosomes at the endoplasmic reticulum, nucleus, and centrosome 11214 5140 10270 5144 5141 5350 10142 9472 9465 PMC7775286__F1 Diagram of NK cell receptor signaling: 27040 3805 6850 7535 2534 7409 PMC7778457__F2 FA signaling in the DNA ICL repair pathway 29128 29089 55215 2177 57697 545 55159 91442 84464 5300 51455 5888 79728 672 675 83990 5889 7516 PMC7778590__F5 Targeting YAP for PDAC therapy 60485 4485 9113 26524 6010 PMC7783806__F8 Pathway signalling network generated from the 1000 most differentially methylated genes 374 5367 170589 3589 7976 2049 2047 9321 2690 4041 7067 1956 2322 11211 7253 7132 2064 1849 1947 3590 2847 1432 6714 9475 863 2706 3861 1850 8717 5587 1241 1785 22834 23468 7159 5602 1459 2870 5347 5771 1326 5728 6416 5566 613 3927 4656 5579 5595 3418 5592 8812 5793 9759 23410 4831 5598 5770 8621 171023 1487 3783 5915 5916 6257 8648 2033 4790 9612 10499 4773 50943 6615 6256 5914 5449 79365 1958 5307 PMC7786923__F8 Lnc-GAN1 repressed cell proliferation through cell cycle signaling pathway 5728 1019 2597 595 PMC7787797__F8 PTP1B in IFN-Gamma-induced neuroinflammation and 6-OHDA-induced neuronal death 1998 1997 10209 627 PMC7790818__F3 Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore 355 581 637 7150 596 PMC7791134__F3 Distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells 6869 1133 84624 6870 3358 50940 7201 551 10268 7200 116 170261 139728 2786 2618 9427 401498 259236 80332 6241 55872 983 259266 11065 3832 891 1277 701 699 9212 157570 10403 3161 332 4117 11004 57405 83540 55165 23627 80152 9833 54821 1894 157313 PMC7795579__F1 Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria 90550 4149 22926 9927 PMC7797150__F4 Prediction of target genes and circRNA-miRNA-mRNA network 256051 28985 9440 2734 51316 84516 4604 22806 26130 9145 5502 147166 92 91 10272 54915 2521 6789 123041 57532 7837 6428 2870 1654 6241 85464 3400 9552 55161 10463 3638 54851 257019 84102 23234 5999 79933 4302 64795 5991 79035 22877 6780 7039 79912 64108 7050 10776 777 8202 51341 7049 55140 11031 3845 124961 55187 4297 81035 463 124590 6655 51199 10209 9117 1843 90316 9686 10454 23394 9392 7046 90655 2043 23118 10802 94101 7048 257397 7412 6422 9928 54676 11276 11135 57584 5515 134266 7326 119504 8723 375519 112858 29982 54910 PMC7798015__F4 Direct and indirect intracellular effects of CCN proteins in chronic myeloid leukemia (CML) 3491 4856 4851 207 4790 1490 8840 581 PMC7804410__F4 The selected miRNAs target genes in KF-Tx cells 5578 3643 4893 5879 613 6850 5163 930 5934 5728 7534 572 842 5266 6256 5970 PMC7804500__F4 PPI network of the 37 enriched genes from KEGG pathway analysis by Cytoscape 4312 7098 3952 4313 4318 3458 4843 5468 7040 3553 857 1432 7422 3586 3091 207 5595 6347 5594 2353 4790 7099 4846 3082 998 7157 929 596 472 627 355 PMC7807182__F6 LPS affecting glucose metabolism in cervical cancer cells through FRA1: LPS inhibits p53 by inhibiting the expression of FRA1, which regulates the levels of glycolysis and aerobic oxidation by affecting downstream GLUT1, G6PD and SCO2 4193 2539 4513 9997 3939 PMC7812220__F9 Protein-protein interaction network 22974 2525 8639 5420 23213 83540 54443 51705 6401 10365 3672 1301 2191 10894 7010 4322 5352 3161 5473 4319 54115 2274 3977 467 56992 701 83879 891 9928 9833 6943 81575 64151 PMC7814589__F6 Signaling pathways regulating short stature in the Debao pony 2691 7200 2690 3479 7253 3643 5163 1280 1297 1298 6662 6660 6657 6664 7474 7097 3549 64386 5330 7043 4318 4615 59341 8740 249 PMC7816272__F3 Dysregulation of NCC and TRPM6 common regulatory pathways 54822 140803 1638 130497 PMC7816290__F7 PPI network and Path-Act-Network analyses 7272 10051 983 3832 10403 1062 64151 9126 79682 83540 6476 PMC7816290__F10 Schematic summary demonstrating the molecular mechanism of anti-ALR McAb inhibiting the proliferation of U266 cells 595 6774 983 PMC7817532__F2 Toxoplasma and Eimeria co-opt the host cFos expression for intracellular development in mammalian cells 7124 387 8503 5295 5291 154 22800 6010 51738 808 9586 817 2033 2737 3725 627 2353 3092 1080 490 476 2893 2892 PMC7818012__F2 Mass spectrometry-based protein‒protein interaction techniques and their applications in studies of DNA damage repair 23649 57654 7515 2067 4968 1069 5557 3980 2074 5422 6119 5558 29935 2072 5893 5887 11284 5423 7874 328 142 5428 1161 4738 7518 546 6117 3981 7520 1643 7508 2068 2073 10714 6118 7158 1642 56949 4331 2547 2071 4438 4361 3014 56941 84309 5888 9978 5425 4439 1022 10036 57646 7486 51720 472 672 902 25 8208 2033 3150 83990 57804 4683 10111 1763 9656 5111 5424 7328 4292 9156 5932 580 675 7334 27030 2956 3978 79728 5395 4436 5430 5984 51426 7153 5981 56655 4437 5378 79184 7155 5982 84142 5427 5426 5983 641 54107 PMC7823834__F2 Agents acting on hormone signaling to revert drug resistance in CRC 2308 861 324 572 581 PMC7823885__F3 Pathways of lipid metabolism modulation in hepatic tissue by the Gl-2 extract of a Mexican strain of Ganoderma lucidum, under a high-cholesterol diet (HCD) given to C57BL/6 mice 467 3304 3303 3337 150094 55902 47 2194 50814 7832 4199 1958 1959 31 2224 2353 60481 3171 5209 26002 471 6722 3725 3164 PMC7824065__F6 Metabolic reprogramming to form metastatic tumors 440 5625 26227 55902 PMC7825801__F2 Cholesterol synthesis pathway 3157 3156 4598 10654 4597 3422 4047 1717 1718 PMC7826839__F1 Role of the adenosinergic pathway in the Glioblastoma microenvironment 8205 145258 1956 351 196 7431 84890 1499 7124 1493 3902 50943 3558 3569 6361 140885 100 PMC7828596__F1 Canonical aryl-hydrocarbon receptor (AhR) pathway 9049 405 196 2938 57491 2052 PMC7830359__F1 Network of differentially expressed genes prior to initiation of anti-TNF therapy based on interactions using Ingenuity Pathway Analysis 94240 10410 3107 3824 8638 3099 4133 5604 10578 PMC7830727__F1 Ferroptotic cell death pathway 8031 2495 2512 2879 PMC7830727__F2 Necroptotic cell death pathway 8717 7186 7185 8772 197259 PMC7831039__F1 mut-p53 alters the communication of tumor cells with their microenvironment 3627 100302142 1606 26060 29110 PMC7831445__F3 The innate immune response to human coronavirus infection 59272 6772 6773 51311 7098 51284 5640 7113 4615 10379 29110 57506 3665 4843 9636 3661 115004 7297 3716 PMC7834960__F3 These pathways play an important role in cell growth, proliferation, and homeostasis, thus, a mutation in anyone may cause cancer cell survival, division and metastasis 1956 6469 6608 2885 5728 2737 51684 324 1499 5163 2736 4087 4088 2735 2475 4089 PMC7834960__F4 Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review) 9817 4485 8772 8452 9113 4193 PMC7835797__F1 Epigenetic Alterations in Renal Cell Cancer With TKIs Resistance: From Mechanisms to Clinical Applications 2621 3082 558 5728 2475 1499 6660 56950 25797 9839 999 2146 PMC7835977__F6 Proposed mechanism by which GAT107 restores bacterial clearance in the lungs by reducing oxidative stress, due to hyperoxia 7808 6647 9817 PMC7836322__F2 Replication cycle of HCoV 59272 1803 5478 PMC7838829__F2 Going, Toll-like receptors in skin inflammation and inflammatory diseases 929 7097 10333 3929 7099 114609 4615 7189 3654 3663 51284 51311 7098 23118 257397 7187 3661 PMC7838852__F3 Diversity and versatility of p38 kinase signalling in health and disease 29102 993 1647 1026 595 8408 3920 10179 7936 8737 3454 10949 3458 3553 7124 3479 861 6663 2670 5081 2146 84872 860 1749 7350 26291 PMC7839487__F1 Intermediate filaments cross talk with different signaling pathways 7046 4087 4088 4089 4485 1499 324 2670 9242 PMC7843579__F8 Schematic diagram illustrating the global view of transcriptional changes in MPTP/p-induced progressive PD mice model 133 3053 2019 717 7054 2006 1813 5580 2475 PMC7844295__F2 Biosynthetic pathways of glycerophospholipids in rat hippocampus 5091 254531 1636 10162 56894 84532 23205 23305 4018 8611 80221 55750 4015 2876 2053 5226 4049 873 4050 874 5228 PMC7844295__F3 Glutathione metabolism 55748 178 5236 2937 4259 2940 2953 373156 2950 2944 2949 3417 3418 2876 2879 23530 PMC7845582__F2 Vaccine Therapies for Cancer: Then and Now 958 920 940 6891 6890 PMC7846844__F8 LincRNAs involvement in muscle fiber hypertrophy signaling by regulating its target genes 3481 3479 3480 90550 6722 5091 5337 PMC7846853__F1 PI3K pathway in the context of BCR signaling along with various targets 613 930 973 974 6850 4615 4067 6774 4772 695 5728 PMC7847386__F1 Nucleic acid-sensing pathways and their evasion by SARS-CoV-2 during COVID-19 infection 59272 114548 8909 51311 7098 51284 23586 115004 4615 57506 29110 3553 3661 3665 79792 PMC7848207__F2 Mechanisms of action and signaling pathways of SIRT1 in diabetic nephropathy 60674 347689 9817 50507 1499 23411 2308 9076 3090 1786 2146 PMC7851145__F1 LPA intra- and extracellular biosynthesis and degradation 4099 4018 5338 5337 5091 3931 PMC7851265__F3 rTSMS regulates functional protein synthesis and pathways 4397 81551 4280 1465 391 10409 23154 60 7070 7345 4340 4155 5879 388 998 5122 6390 291 811 11315 6648 2944 10963 4831 5478 10935 6647 302 7001 PMC7855700__F1 Main IDO1 and ARG1-mediated pathways that regulate autoimmunity, cytotoxicity, and neuroprotection 6714 383 196 3620 PMC7856101__F2 Gut Microbiota in Epigenetic Regulation of Colorectal Cancer 999 1499 7099 6774 PMC7857022__F1 Class I PI3K signaling pathway simplified 613 3845 5163 5728 6009 7249 7248 PMC7859916__F2 Role of Eps8 in the regulation of the malignant phenotype of a tumour 1950 1956 2059 2885 6714 2475 6774 2932 2305 595 PMC7862225__F2 Build-UPS and break-downs: metabolism impacts on proteostasis and aging 338386 7494 51019 83939 8408 7942 1938 3297 PMC7865468__F1 TGFB in Cancer: Metabolic Driver of the Tolerogenic Crosstalk in the Tumor Microenvironment 2885 4087 387 4088 857 3939 5209 11001 2475 2203 3417 2729 PMC7867633__F4 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes 1977 3479 5728 9776 8408 3717 5617 5618 4827 27343 11201 6606 PMC7870784__F5 Model illustrating the miRSNP → miRNA → risk gene → pathway effect PSD 406941 627 3716 3479 5662 PMC7872968__F7 Phagosome maturation pathway, (B) RIP1 and ECSIT signaling pathway, (C) arachidonic acid metabolism pathway, and (D) cytotoxic T cells signaling pathway using CD226 and PVR axis 7124 7186 8772 8411 10379 51295 7189 23118 10454 5817 PMC7874138__F3 HCC cells by SIRT4 9314 23409 619501 383 6774 8205 8443 38 2194 6737 2475 PMC7875919__F2 Lipid metabolism by the unfolded protein response 255738 1376 3949 6785 55825 355 47 3156 4547 7038 3630 84649 23175 1119 1120 4018 PMC7876385__F3 Major mechanisms of drug resistance in BCSCs 9429 5728 6774 2735 2475 1499 324 2736 2932 4040 5727 PMC7876405__F1 p38MAPK-MK2 axis is activated in response to diverse inflammatory stimuli 4615 7189 90865 7186 8717 7124 7098 10454 23118 7099 257397 PMC7877185__F3 Competing endogenous RNAs (ceRNAs) and the signaling pathways involved in lung cancer cell invasion and migration 7503 9839 2308 442912 8091 100499467 23642 6935 7422 1950 100287569 2146 1956 7046 7048 7049 26579 860 4087 4088 8567 23476 5728 4089 51527 57291 2475 8751 10397 2932 1499 6611 57468 79776 406939 999 1000 4313 4316 4318 4320 PMC7878365__F3 Sestrin modulates cell signaling networks in physiological responses to environmental stresses 83939 22926 468 7494 83667 8408 9817 27244 143686 4092 4087 4088 4089 PMC7878386__F1 Leptin receptor isoforms and intracellular signaling 3717 2885 3667 8660 9021 6774 PMC7880612__F1 Molecular tracing of prostate cancer lethality 595 999 7490 3964 7031 6696 6659 4602 5728 4089 960 6662 79923 53635 367 2146 429 PMC7881277__F1 Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology 3845 56848 4513 842 572 PMC7881277__F4 Neurodegenerative disorders signaling pathway and the predicted gene targets of miR-19a (SOD1) and miR-126, which are involved in the insulin signaling pathway 5072 6622 65018 7345 170534 120892 11315 4929 351 572 4744 57679 6647 320 348 834 598 840 836 581 4804 2670 333 3309 596 2885 841 839 1387 PMC7881399__F1 Cluster-1 including 24 nodes and 176 edges 7432 595 5697 7422 5743 999 1029 3952 2922 3576 7099 1956 6356 2875 PMC7883590__F2 Myd88- and TRIF-Dependent Toll Like-Receptor 4 Inflammatory Signaling 7099 3656 4118 7189 929 10454 3929 7187 7124 4513 3553 29110 3661 PMC7884075__F4 GWAS hits in the IGF-1 pathway 3479 2693 2688 2689 2690 6774 8835 25970 7067 3486 3483 3630 3641 3481 11172 723961 3480 3482 3667 6464 22808 5728 5922 51050 5266 54453 25837 9545 5866 79874 PMC7884645__F2 NLR in eXile: Emerging roles of NLRX1 in immunity and human disease 7939 55054 9140 9474 79671 7284 57506 7187 7189 3661 3665 115004 PMC7887427__F7 Differential gene expression of EGFR pathway proteins in TPC1-deficient MEF cells compared with wild-type cellsColor code indicates gradual changes in expression 6464 2885 4582 6654 867 1499 999 1956 7409 4690 6772 3716 3717 5894 5879 6714 5058 5163 4214 998 6010 6774 207 208 331 2475 4193 6198 6416 5609 9641 2002 4893 3265 3845 22808 5287 8536 817 818 5295 23533 PMC7888617__F2 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone 5728 2932 595 7249 7248 6009 2064 5290 3084 2065 2475 2885 572 596 5170 6198 51384 7481 1499 324 5879 3667 6722 2002 1839 2353 3725 1956 2005 1950 6774 6667 4088 4087 PMC7888617__F3 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone 2064 3084 324 595 5879 1499 5728 4609 7249 6009 2475 3667 572 596 2885 1839 6667 1956 6774 1950 PMC7888617__F4 Targeting oncogenic mutations in colorectal cancer using cryptotanshinone 2064 324 595 5879 1499 4609 6009 2475 572 596 2885 1839 2065 6667 1956 1950 PMC7890031__F1 IL-17A on osteoclasts 7187 7124 4843 PMC7890422__F1 Caveolin-1, a master regulator of cellular senescence 6667 857 1956 4193 23411 3146 3479 6010 PMC7892431__F2 Viral manipulation of DNA-sensing and directly antiviral signaling pathways 115004 9447 54106 7706 3428 81844 834 57506 29110 4615 3661 3665 114548 3553 83939 103 6041 PMC7895883__F1 Negative (blue) or positive (pink) regulation of TET2 in the inflammatory immune responses and related diseases 54790 9021 383 3665 5132 51523 27343 11201 4023 920 50943 PMC7896717__F3 Gene networks showing signatures of pervasive positive selection in Han Chinese and/or Japanese populations according to signet analysis performed on whole genome distribution of nSL scores and aimed at testing for polygenic adaptation 57678 10365 8526 847 50508 5331 1386 5581 5590 PMC7897342__F2 Role of the ATF/CREB family in the pathway involved in hepatic lipid metabolism 22926 355 83939 23411 468 7038 1374 26291 5465 336 337 58487 56848 PMC7898179__F6 Input-output signal processing plasticity of vagal motor neurons in response to cardiac ischemic injury 2922 2925 4883 10682 7054 5998 1621 7225 6750 885 7432 PMC7898466__F1 TLS pathways for replication through UV lesions 353497 5426 11201 51426 5428 51455 PMC7898466__F7 TLS pathways for replication through Tg and EdA lesions 7038 51426 5426 51455 PMC7898953__F1 Extra-cellular and intra-cellular signalling regulating cardiomyocyte proliferation and cardiac regeneration 1499 3084 60485 4485 9113 26524 3976 983 1017 1019 PMC7899014__F10 Cell signal transduction pathways of 7 central hub genes in CMs infected with SARS-CoV-2 7099 59272 3576 3554 4615 5606 7189 2534 5340 5054 3661 3665 3725 2353 6772 3456 729230 6347 PMC7900187__F2 Immune cell amino acid metabolism following mycobacterial infection 383 384 435 445 PMC7900570__F1 Growth Hormone Signaling Pathway with highlighted Glucose Uptake micropathway 5777 2690 3717 3667 6774 3480 6772 2002 6722 5163 3479 3481 PMC7900570__F2 Node activation of Growth Hormone Signaling Pathway for gastric cancer sample GC.11_S19_R1_001 from 5777 2690 3717 3667 3480 6772 2002 6722 5163 3481 3479 PMC7902134__F3 Yixin-Shu Capsules Ameliorated Ischemia-Induced Heart Failure by Restoring Trx2 and Inhibiting JNK/p38 Activation 5465 108 2767 5167 200539 57104 27302 859 5979 4016 9722 121340 8074 5728 7168 4625 7137 1264 148 4615 5468 7018 1674 2281 2668 1832 64135 1277 11155 930 4604 4634 3303 4089 8517 85366 914 7249 2717 10736 779 51316 3728 4939 4747 1756 718 8516 5176 1356 7273 2006 1278 283208 7139 140823 7169 9118 4632 1297 6181 7200 10232 846 59 1300 9510 3032 2026 1268 PMC7902504__F1 Kinase pathways mediate dendritic morphogenesis and maturation 150094 27 10152 9344 22848 1859 2475 4485 1020 57551 3984 627 387 989 4082 PMC7903350__F6 Compound-target network of EIF 5604 27043 2309 3480 5618 1956 1026 6654 598 1950 2770 2885 4193 9564 7422 3643 7157 3791 207 2033 5728 1586 1387 2475 1588 6714 5770 2778 2185 8648 10499 2932 4846 2099 472 3630 5295 367 5294 5290 2796 3814 6865 1543 6863 6870 3667 2691 54331 6866 5515 25 7414 PMC7904555__F1 Pro-inflammatory signaling pathways of TLR4 7099 3929 929 7189 7187 3553 3665 3661 114548 114609 4615 PMC7905024__F1 CGAS-STING and TLR9 signaling in response to the recognition of host-derived self-DNA as a DAMP 115004 7189 54106 3146 3661 114609 4615 51135 23118 257397 PMC7906182__F3 MetaCore pathway analysis of coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer patient databases 25859 847 5347 983 8556 324 11186 1017 6950 993 991 1431 699 9184 6502 PMC7907897__F2 NRF2 regulatory mechanisms.A) three reported negative regulatory mechanisms of NRF2 7494 8452 8454 9817 1645 2879 2877 4363 10057 10257 1244 8714 9429 2495 51 200879 3417 2539 2936 2730 9474 5693 5682 5888 196 4851 4094 672 675 10072 PMC7910492__F8 Mechanism for the synergistic effects of BKM120 and olaparib on the death of MDA-MB-231 cells 142 10038 6741 2308 9156 675 672 5888 5893 PMC7911352__F2 Cyst(e)ine-glutathione-GPX4 axis regulates ferroptosis 8678 8314 55611 23657 3417 2937 2879 3309 468 22928 PMC7912581__F2 New paradigm in the mechanism of GSIS in the context of the regulation of insulin secretion 6616 7220 6786 50507 4199 3417 5091 6750 3418 2740 29850 54795 7432 2695 5697 339855 7226 100170220 84876 PMC7912581__F8 Complex mechanism of FASIS and (B) GPR40 receptor part 7222 7220 6786 50507 23410 4099 139760 29850 54795 2695 5697 7432 339855 7226 7038 100170220 84876 PMC7912842__F1 Fibroblast growth factor-FGF receptor (FGF-FGFR) and cyclin D-cyclin-dependent kinase (CDK)4/6 pathways in breast cancer 5806 367 10818 2885 1499 729 2475 7249 595 1021 1019 1017 PMC7913382__F6 PI3K/AKT/mTOR pathway in pancreatic cancer is central for cancer cell growth, survival, migration, invasion, angiogenesis, and modulation of the anti-cancer immune response 5728 2885 5163 6774 7249 7248 57761 6009 8205 920 PMC7915224__F6a Ins and Outs of RAS Effector Complexes 5900 2475 4609 472 545 355 2932 1017 1021 1019 8772 1874 1871 144455 1875 1869 1870 1876 85451 23085 6010 PMC7915278__F4 Functional networks of proteins involved in the following pathways: (A) B-cell receptor (BCR) signaling pathway (hsa04662), (B) cellular adhesion molecules (CAMs) pathway (hsa04514), (C) PPAR signaling pathway (hsa03320) 7410 6654 6655 3676 3385 5894 3635 3688 5175 8517 4893 29760 3551 973 9019 930 5777 1365 3683 5880 10451 3684 6385 914 8174 3845 2734 5788 4772 974 7412 4684 8915 4792 5970 6614 3897 5296 6402 942 975 25780 7409 27071 3655 5604 971 3695 50848 2885 4790 5533 3113 4067 1147 3115 6693 3383 3689 4773 940 23114 207 5293 958 5295 999 695 933 965 3685 1272 5290 5879 1380 208 3119 4267 3122 6850 5532 3109 3133 10892 5294 920 4793 2932 3111 3105 5530 11261 3112 5792 1593 30 1622 5360 2180 2181 5106 51703 335 6342 1962 2182 51 376497 8310 79966 23305 11001 345 34 1376 2171 10999 1374 PMC7915278__F5 Selected network of 138 proteins that were found in a functional screen for proteins involved in the pathway in cancer (KEGG: hsa05200) 2271 6789 7185 4149 9063 330 405 2956 1147 3551 4437 6513 4791 8517 54205 4436 8554 1387 5371 3066 7186 598 4087 637 9978 4292 7048 208 6688 2033 7175 7042 4318 2475 836 596 6257 10342 1856 7046 1487 1857 5578 5296 5290 7040 8030 867 5335 3845 5295 54361 5294 387 10928 7184 3815 2885 5336 5747 613 5880 998 5898 3728 1399 1398 5899 3655 369 1495 3915 6655 3914 3909 207 3320 3480 5595 2335 1499 5879 5599 4089 3685 999 3688 842 5604 PMC7915460__F2 EphA2 signaling in normal (A) and cancer (B) cells 1969 1956 999 6714 6010 998 867 PMC7915726__F5 MERTK in Yes-associated protein (YAP)-mediated EGFR-TKI resistance 1956 1950 5163 4485 55233 92597 2305 PMC7915848__F4a Increased Tenascin C, Osteopontin and HSP90 Levels in Plasmatic Small Extracellular Vesicles of Pediatric ALK-Positive Anaplastic Large Cell Lymphoma: New Prognostic Biomarkers? 8828 5806 735 7130 7422 1462 2192 4958 7448 7157 54757 8704 3320 857 3371 351 5747 3688 7184 4684 23193 6696 6210 1956 6233 3725 3326 725 3178 3929 6774 1401 4673 6288 PMC7916307__F2 IAP-p53 axis is an essential regulator of a multitude of cellular pathways 688 331 29102 7018 332 4671 3313 3066 4513 54739 6774 1956 8554 4193 PMC7916426__F1 BA synthesis and transport pathway 5091 2264 1581 9414 4945 9965 5205 PMC7916440__F2 Simplified overview of major protective signaling pathways involved in RIPC, the reperfusion injury salvage (RISK) pathway, and the survivor activating factor enhancement (SAFE) pathway 6774 5163 2932 572 581 PMC7917312__F2 Armed oHSVs for GBM treatment 3458 79465 83939 10219 999 PMC7918168__F6 Action mechanism by gallic acid and rutin on mitochondrial functions in C2C12 myotubes 55669 9927 51024 4976 4899 9474 10533 79594 7019 4709 6390 PMC7918665__F2 Major groups of micro RNAs (miRNAs) and their related pathways by which they act on endothelial cells 5728 2885 2475 581 213 192 406913 693175 100126343 406992 407010 494331 100313781 406947 PMC7919044__F2 G protein-coupled receptor (GPCR) kinase 5 (GRK5) activities within cardiomyocytes, cancer, and neuronal cells 1950 1956 1839 6714 10013 4775 596 PMC7919457__F3 Gene fusions in pancreatic cancer 8030 8031 7373 9908 27436 23189 481 9578 8671 999 1004 3084 2065 5979 2263 4914 4916 238 6098 2885 23024 5210 10125 6238 1523 27044 8805 3845 5894 3337 673 5566 5908 5906 369 PMC7920173__F1 Autoimmunity in Acute Poststreptococcal GN: A Neglected Aspect of the Disease 717 718 729 735 730 PMC7920303__F3 Metabolism of small, neutral amino acids including serine (Ser), glycine (Gly), and alanine (Ala) 84706 6509 6510 26227 51660 25874 81539 54407 29968 54977 5723 5212 94081 81855 PMC7921686__F7 Target-pathway network, constructed in Cytoscape3.7.2 (https://cytoscape.org/), was built by the candidate targets and a pathway if the pathway was lighted at the target 3815 4313 3718 3320 3558 1017 836 5599 5781 4314 3791 2066 4193 5914 5241 650 PMC7923093__F5 Regulatory pathway of differently expressed miRNAs 187 1139 7184 55593 1389 10618 1665 9942 55754 5504 5906 6059 5552 9135 79083 145482 6000 64641 150280 1581 2895 56302 6291 7456 9217 785 54107 10096 6584 474354 130733 221191 836 4152 4857 3487 22808 183 84779 6751 9022 402415 91445 23609 51320 2692 57446 64976 PMC7923165__F2 B-cell receptor signaling pathway is enriched in SYK targets in the DG75 Burkitt lymphoma cell line 933 971 6850 613 4067 29760 695 2885 25780 2638 8915 930 PMC7926651__F4 Main mechanisms of Kupffer cell activation during chronic ethanol exposure 114548 3553 7099 834 PMC7930427__F2 Molecular Profiling of Exceptional Responders to Cancer Therapy 5801 8399 64399 6927 4331 2932 23451 673 2967 79009 2885 5566 1786 25 79089 2778 139285 994 27040 5880 7043 1436 8324 5577 3560 929 2619 7044 7060 3371 PMC7930745__F3 TMEM16A regulates cancer cell proliferation 387 4087 4088 4089 1000 999 PMC7934812__F1 Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation 7099 114609 4615 7187 7189 3661 PMC7936154__F1 Examples of potential miRNA-mediated regulation of metabolic pathways in chickens 3479 574033 574032 406968 574455 407008 407040 572 5465 6256 100302170 PMC7936661__F3 Short loop commonality and a landscape of short loop commonality among proteins with mutations in the AML PPIN 613 3815 4486 3643 2322 4352 5795 5787 5793 2213 5310 6464 867 84951 868 2268 6654 PMC7937931__F3 Relationship between genes and their genetic functions 4313 5595 5243 9353 29108 7422 1950 5328 4609 7494 2064 2886 11186 367 5925 7161 3725 3169 5728 5447 2625 100188835 2100 7033 3480 5266 2096 596 595 324 1956 4255 472 4582 572 3397 6714 5743 PMC7938465__F3 Protein-protein interaction (PPI) network of DEGs 2823 115908 1894 55872 4751 3161 54443 259266 6241 3556 701 1033 51514 9055 891 7153 983 6718 6716 2099 10486 148 1306 6091 51302 1549 1634 6783 6387 9547 6696 1555 590 3082 2920 1544 3479 2719 64399 57817 83875 1592 1548 10 3483 2690 28234 6690 127 169355 8564 3083 1559 6580 51179 6296 735 4018 10249 5067 8547 27165 4494 143941 3931 319 8406 229 4499 2220 84735 8876 51266 2998 1393 339390 29127 PMC7938465__F5 Re-analysis of 15 selected genes via KEGG pathway enrichment analysis 472 545 637 581 1869 4609 842 836 10572 64065 84883 7249 5728 PMC7940873__F7 LncRNA-mRNA co-expression network analysis 2246 10488 3659 1385 7448 7132 60674 5295 468 1051 11035 330 1435 7133 3627 3725 5934 2919 6364 5609 9252 57761 1943 6347 355 6199 10971 5585 9021 2920 1437 5970 7058 6300 8823 4318 2921 3383 6416 1906 8737 PMC7946937__F4 Rewired signal pathways by deregulated Myc in cancer and its related components available for synthetic lethality 7494 983 5591 8896 PMC7947364__F1 Summary of the cellular metabolic effects of hyperglycemia in cancer 9712 1956 3480 999 3099 2194 2885 PMC7947625__F1 Mevalonate (MVA) pathway and its connection with the intracellular energy metabolism signaling 3418 3417 3652 PMC7952134__F4 Bioinformatic pathway analysis of proteins with altered phosphorylation site occupancy in PPP2R5D E420K-variant cells.A, proteins associated with enriched KEGG pathways identified in F 5728 7249 1022 4173 7465 5591 868 208 54434 6464 6502 2033 1902 6249 10152 2475 983 545 324 8660 6237 10297 9475 9133 4171 10163 1398 8315 4638 4619 6476 7405 8440 9839 55696 154796 1741 7175 10921 116985 23513 9688 5371 80230 7408 8777 8449 3725 6643 27316 7456 5631 8853 22916 6426 64798 1147 387 PMC7952883__F3 General mechanisms of sildenafil in different types of cancer 2475 3845 383 9429 4363 5243 1499 5311 PMC7956519__F2 Main non-canonical signaling pathways activated by JAK2V617F in Ph-negative MPNs 4059 2057 3717 114609 4615 7189 10419 1386 PMC7957553__F3 ROS-dependent transduction signaling 9817 2353 3725 6648 1728 57716 PMC7957592__F7 Influence of TP53 on FAM72 paralogs directly regulates the cell cycle in cancer 56616 207 5294 839 7157 5728 836 842 54205 4193 840 598 596 581 11200 1111 4170 545 472 4605 1017 578 5925 5934 637 5933 729533 1869 7027 1870 23380 653820 728833 3622 PMC7958144__F1 Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation 2641 2740 6750 3630 PMC7959785__F2 Biosynthetic pathway of selenoprotein translation 22928 51091 118672 79048 2876 2879 1734 7296 PMC7960772__F1 Immune environment surrounding a transplanted organ 920 324 3902 201633 941 942 8178 383 PMC7960940__F7 IPA network analysis of differentially expressed proteins in G6PC3 deficiencyIngenuity Pathway Analysis (IPA)-based network 1 of the 148 differentially expressed protein panel 100423062 7980 717 1606 2353 940 2626 2625 916 8600 59067 2022 3596 5176 5743 6778 713 23236 604 5294 2878 PMC7961896__F1 Molecular mechanisms regulating skeletal muscle mass 655 10220 3479 7186 3480 4091 5728 4087 4088 7249 6009 253260 2475 1386 4094 1998 664 117154 PMC7962393__F7 Functional Prediction of the Key Genes Involved in HBV Associated HCC 259266 10051 83461 7153 4288 8717 11130 10403 55635 983 1017 4751 51203 6908 6790 3161 1063 9493 890 891 9055 1062 899 3832 10112 24137 9837 995 1021 6502 5885 10274 9126 699 2810 472 5111 5591 902 4609 25 4087 4089 7040 3065 5925 6500 4999 4171 4172 8317 10926 PMC7962738__F1 Glycolysis, gluconeogenesis, glycogen metabolism, the hexosamine pathway, oxidative phosphorylation, and the TCA cycle 5236 2821 5211 2203 8473 226 7167 2597 5230 5223 5105 51660 25874 5091 5166 1431 4967 2271 619501 PMC7962738__F2 Glutamine synthesis, nucleotide biosynthesis, and the pentose-phosphate pathway 2539 6888 7086 6120 5631 5471 790 2618 5198 7372 4975 7808 51727 83549 7371 10606 6240 7378 158 1841 56474 1503 7298 7083 1890 8833 204 2987 619501 4860 6241 PMC7962892__F1 TNFAlpha-induced signaling pathway of cell survival, apoptosis and necroptosis 7186 7188 8717 8772 197259 PMC7969115__F3 Biomarkers play role in pathology of OA by multiple signaling pathways including NFKB pathway, MAPK pathway, Wnt-signaling pathway, and TLR pathway 7099 4040 4041 324 7412 3383 4318 4322 3569 1386 PMC7970116__F1 Mechanisms influencing immunotherapy response in the TIME in ccRCC 100 3902 383 942 PMC7970116__F3 Genomic characteristics of ccRCC for manipulating the TIME 11201 7428 383 3458 3627 5728 6347 PMC7973006__F1 In stationary state, the aryl hydrocarbon receptor (AHR) is part of a complex composed by the 90kDa heat shock protein (HSP90), the co-chaperone p23 (p23) and the hepatitis B virus X-associated protein (XAP2/AIP/ARA9) 196 405 57491 100188857 1545 25976 PMC7977493__F8 Stiffness of Nanoparticulate Mineralized Collagen Scaffolds Triggers Osteogenesis via Mechanotransduction and Canonical Wnt Signaling 4090 4086 324 1283 860 6010 PMC7978298__F1 Primary generation and elimination mechanisms of intracellular ROS 50508 50507 5879 124056 10811 27035 847 57716 2539 4199 4118 3417 2242 3418 4522 10873 PMC7978298__F3 ROS induce cell death, mainly including apoptosis, necroptosis and ferroptosis 355 7124 8717 8772 23657 6520 57103 5836 2752 2746 842 PMC7979820__F2 Epigenetic mechanisms in breast cancer therapy and resistance 27122 6469 5727 999 1499 2735 2932 PMC7981598__F2 Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs 59272 1636 545 PMC7982415__F2 TLR-mediated signaling pathway 7099 4615 51284 7189 7187 3656 3654 51135 23118 257397 10454 8772 836 197259 114548 PMC7982415__F4 NLR-mediated signaling pathway in mammals 10392 3428 9447 114548 3606 23118 10454 79792 834 837 838 PMC7982634__F4 Natural extracts block NF‐KB signaling pathway 7124 54472 7186 8717 4615 51295 PMC7982634__F1 Natural extracts can induce apoptosis through ERS pathway and mitochondrial pathway 581 637 100506742 2021 468 1158 PMC7985179__F2 Key proteins and interactions in coronavirus disease-related pulmonary fibrosis (COVID-PF) 840 64127 11213 1058 701 959 59272 1803 5045 1059 5806 3553 93659 7124 3958 1081 7045 5468 7490 1435 5617 7422 1191 3156 2261 5578 2069 2263 5582 627 2932 2255 4915 2990 3084 1312 4524 9043 4593 2581 4914 4137 351 348 213 7448 1356 942 941 4982 6532 1588 968 7040 6647 1636 3479 3569 PMC7991918__F7 Targeted molecular and biological pathways’ interaction map analysis performed on the genes from the red module 7531 5621 8514 2280 10381 6616 10540 1759 8452 10938 226 5911 5770 9146 55748 10097 10529 9218 811 5217 6642 5471 PMC7997185__F1 NEK1 and NEK2 play key roles in the DDR pathway 338340 6741 9874 4750 472 545 84126 2956 2175 7428 4361 4751 4869 993 983 PMC7997185__F3 Possible involvement of NEK6 and NEK7 in DDR 472 140609 545 10783 PMC7997185__F5 Signaling pathway of NEK10 and NEK11 upon DNA damage 472 545 152110 5894 79858 993 983 PMC7998595__F1 Autophagy pathway in podocyte 9776 2308 8408 2309 10645 8878 55054 9474 7249 9140 8678 2475 7942 133746 596 123720 PMC7999074__F2 Activity of YAP/TAZ is influenced by various metabolic cues 6010 5163 2475 8473 1499 2805 29968 3099 3098 5210 5214 6510 5230 3156 81539 3939 355 8140 6507 PMC7999163__F2 Possible mechanisms through which the gut microbiota could affect the homeostatic and hedonic pathways 23237 4852 5091 181 5697 PMC7999169__F6 mRNA-lncRNA co-expression network of the blue module 2920 144453 374 3280 2069 4005 2184 100126791 3097 29028 9415 2633 8741 7227 10253 9636 133 467 100130476 8743 8519 PMC7999907__F3 Metabolic reprogramming is mediated by HPV 16 E6 variants through c-Myc, hypoxia-inducible factor (HIF)-1A, WNT, and miR-21 324 1499 7428 3418 3939 6774 948 133522 2194 PMC8000236__F6 Top predictive features for not mutated IGHV CLL patients 8626 5548 998 3479 3577 5465 PMC8001769__F2 Schematic view of controlling cancer hallmarks and associated signaling pathway by lncRNAs 60674 728655 283120 400550 652995 378938 104797537 55384 440823 100124700 109245082 105416157 100642175 100750225 7808 647979 64002 2475 472 3480 PMC8001868__F5 Summary of some of the effects of allicin on eukaryotic cells 55364 9817 10413 PMC8001935__F3 PPI-specific gene-regulatory networks of top 5 KDs in IGF-I and IR (eQTL mapping) 2066 8766 5604 4691 405 1460 6188 3265 23236 808 23533 7532 5515 5530 208 64837 5590 3643 2885 1000 2241 83737 5792 2242 613 57530 3566 5789 3667 5015 489 487 PMC8001967__F3 Mitochondrial regulation of ferroptosis 2395 9054 3418 118980 6132 1431 2271 80221 637 9361 2805 PMC8002185__F3 Serine/glycine biosynthesis pathway activation in tumor treatment resistance 1956 3845 673 26227 468 29968 4609 5723 6472 6470 PMC8005985__F4 Regulatory effect of H19-LncRNA in cardiomyocyte maturation 2932 100033819 7416 54997 283120 55553 PMC8006752__F1 BAP1 nuclear and cytoplasmic physiologic activities 5888 171023 54617 8314 55252 580 80816 221937 3607 8473 23657 90550 672 PMC8007973__F4 The Wnt pathway in normal tissue (A) and in our two pancreoblastoma cases (B) 324 1499 4040 4041 PMC8007978__F2 Metabolism of macrophages is beneficial to host defense or pathogen survival of during Mtb infection 3099 3098 2147 5209 5132 383 445 3418 PMC8010076__F2 Clustering and pathway analyses of proteins quantified in EAE and CPZ 12 2266 2244 5265 348 197 9636 6447 1211 682 1356 2170 811 158931 223 7163 6647 3162 6280 572 5468 639 10049 2335 23657 3689 3684 29927 2052 1508 4942 5052 2539 1509 9446 5696 5226 2670 29968 444 230 50650 1992 6141 2876 5479 4780 6774 5947 64218 301 1601 10808 9588 2316 3032 7171 5725 7332 1859 1192 29855 11335 PMC8010701__F3 Cholesterol homeostatic processes governing the vertebrate retina 338 4035 3949 948 19 6120 38 1593 3156 4598 6713 1718 10858 PMC8012461__F2 Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation 4485 6010 4771 9113 26524 154796 1495 2932 1454 8945 2066 7161 1958 6910 374 3689 4609 7431 2736 PMC8012550__F4 Genome-Wide Association Identifies Risk Pathways for SAPHO Syndrome 8685 10990 1520 2213 30835 29119 4688 5533 8631 83593 3684 2206 5321 5530 6300 1435 3673 1540 3567 6464 5608 1793 5879 3459 3551 56848 1513 2335 5590 55616 5293 50807 9965 2256 26291 5578 5170 2902 2253 3630 273 1398 200576 83547 84617 528 245973 5878 PMC8012850__F6 Schematic representations of the gene regulatory pathway controlled by Oc factors in the chordate retina 5629 10814 10590 57709 160335 55799 2559 2555 64211 5081 5077 4117 5147 5080 121643 7068 4901 6258 PMC8013908__F1 COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options 1514 51284 4615 51135 7189 7187 3665 7113 59272 5045 7098 29110 3661 8829 7099 3654 3066 8829 7099 4615 51135 3654 7189 7113 59272 5045 1514 51284 7098 7187 29110 3665 3661 3553 3066 PMC8016646__F2 Promotion, composition and intracellular activation of the VEGF‐VEGFR signalling pathway 7424 7423 7422 2277 6461 2549 572 2534 6714 2475 PMC8020906__F4 AMPK pathway activation and energy homeostasis 10645 10628 3156 8408 2997 PMC8021683__F1 Summary of signaling pathways regulating cardiomyocyte proliferation 3084 2064 2066 5163 2932 324 4485 26524 1499 595 7018 1028 PMC8021790__F2 Regulatory network model for alanine, aspartic acid and glutamate metabolism pathway(enzyme, posttranslational modification, activate, inhibition, catalysis, reaction, and combine 2911 1740 2915 6654 9771 5266 3084 3265 6714 2048 6464 160 2773 2778 183 3055 1759 5335 718 2771 10681 1604 123745 5894 2767 5567 23236 2147 5146 2776 23327 5568 5592 6844 2571 9482 5142 468 6616 2572 5144 440 PMC8025348__F2 Main mechanism of F 201633 7099 1499 3553 1958 7124 341567 999 PMC8026307__F2 FOXO1 activity by periodontal microbiota in gingival epithelial cells 23118 51701 2308 9839 6648 847 10935 7097 8717 637 PMC8027777__F9 Graphical illustration of proposed DEX-mediated preservation of mitochondrial fusion and fission involved in regulating HIF-1a/HO-1 pathway 55669 4976 51024 9927 PMC8032655__F6 Cell cycle at high altitudes (The purple boxes represent enzymes or genes, green box represent down-regulated) 4089 4088 3643 5728 3630 5163 1950 2885 PMC8033157__F3 Immune evasion by coronaviruses 7099 59272 6868 7297 6773 7187 10379 7189 29110 6041 6035 9636 115004 4827 3661 3665 57506 4771 PMC8036620__F4 Apoptotic pathways involved in CIAKI 8717 468 8772 PMC8036964__F7 Target-enriched KEGG pathway network for UR alkaloids against AD 1137 1141 5027 1131 8622 2558 43 3643 3363 4843 4313 983 2260 1129 5144 3356 3362 2261 5159 2534 4846 6532 3358 1436 2064 1812 1565 3360 595 3815 2475 1813 3350 3579 207 154 240 4842 4915 6571 4128 4318 1234 4914 2932 836 5602 1814 5743 25 1815 6531 2904 4916 1020 5663 834 142 4314 5664 823 9451 55851 83464 23385 6868 4311 PMC8038842__F2 Human mitochondrial fatty acid biosynthesis (mtFAS) pathway 197322 27349 54995 387787 11019 51601 109703458 1743 1737 1629 51102 8050 PMC8039208__F4 Effects of circRNAs on the Warburg effect-associated signaling pathways 3099 2821 6774 2319 2597 5230 207 2023 3939 PMC8040296__F7 PI3K-AKT Signaling Pathway 3667 4609 5008 3371 7054 PMC8042171__F2 Genetic glycoengineering in mammalian cells 9488 80235 8869 6487 6482 10402 6483 6484 55650 93183 5277 8708 7368 2583 8705 9334 27090 10610 81849 55808 30815 256435 283358 53947 7357 338596 6489 51046 7903 29906 8128 84002 4247 2530 124872 3703 201595 2683 8703 8702 85365 56052 10195 79868 4248 84920 79053 55757 56886 4245 152586 28 9245 51301 7054 10678 10331 79369 192134 84752 93010 374907 140805 26290 2591 55568 63917 11226 374378 8693 2590 51809 11227 79695 114805 50614 57452 2589 2650 27087 56913 4242 3955 5986 23509 2527 2525 2651 140687 23275 145173 2529 2526 2528 8473 146664 2523 148789 51083 9215 120071 2218 10329 79147 84899 160418 83857 160335 286148 23333 147991 283417 152002 727936 283464 56983 143888 79070 2131 2137 2134 2135 11285 26229 64131 64132 79586 54480 22856 337876 55790 55454 7173 8985 23127 79709 717 PMC8042688__F1 Biological interactions among the formaldehyde-related genes, a hematological malignancies, and b cell processes 2057 4353 3265 2149 4193 847 3565 836 3553 2952 3558 7124 472 7422 6347 3458 142 3586 3562 5551 7040 2950 7412 7157 5743 596 2056 4953 5728 3606 3014 3605 8600 3569 355 581 567 7099 958 3162 1026 PMC8045781__F2 Oncogenic RAS-dependent control of cellular metabolism 3099 3098 2023 2673 9945 6120 22934 6510 2744 2806 2194 2879 4199 2805 3845 4513 PMC8046019__F1 Ghrelin-induced effector pathways and unavowed signaling hotspots 116842 2690 4087 4088 23411 4092 6648 3717 6714 6009 4089 2475 8408 9776 PMC8046170__F3 Human complement cascades 1401 1195 716 717 721 727 735 730 729 7448 720 PMC8046396__F2 PPI network of HT consists of 43 nodes, 234 edges, an average node degree of 17, and a high-confidence interaction (0.7; ) 5111 5934 898 5933 10419 1028 894 1027 1026 3685 1030 1874 595 3280 5925 367 7157 1029 4088 2099 8650 3479 4609 1499 1588 5617 5468 3630 3486 3569 3952 6868 6256 348 51094 335 79602 51129 7124 PMC8047194__F1 Hippo signaling pathways in Drosophila and mammals 4771 2196 120114 79633 4485 60485 4478 9113 1022 9686 PMC8053610__F7 The underlying mechanism of calycosin effects on signaling pathways and the induction of apoptosis in GC cells 1017 999 1021 1019 572 1499 PMC8057295__F1 SHH pathway in the (A) absence or (B) presence of the SHH ligand 6469 23432 5727 374654 8454 51684 2932 2736 2737 6608 11127 8405 8452 64399 156 25989 2735 64750 57154 PMC8057295__F2 Schematic presentation of upstream regulation of the SHH signaling pathway and its associations with other cancer-related cellular pathways 100302142 3170 3091 6469 7546 6095 4212 1875 79577 2475 1499 1950 PMC8062726__F5 Protein-protein interaction underlines genes from virus response as network-hubs 6672 54464 4499 3959 55802 85441 4493 4494 684 7706 4501 219988 6773 6737 9111 51056 1230 6373 4502 962 4495 5721 23347 10379 56259 5341 3431 5720 3627 81030 64108 3433 4283 6351 3665 4088 8638 3429 57169 5684 11274 6741 5698 2633 6348 6497 64761 1657 4600 5743 5696 29126 10346 129607 6890 3937 6648 2634 3553 54625 8519 151636 57674 114769 117289 3600 2635 63875 11262 837 10616 6347 10581 3552 93349 10410 834 355 7098 64976 3601 843 PMC8062726__F7 Summary of the regulated pathways during DCs-T 4772 5954 624 3827 2767 5330 2770 11211 1855 7124 3592 7098 148022 3659 54106 7096 51284 7097 3663 948 10616 958 64127 8767 941 6714 6850 7706 3456 10010 3439 57506 7187 9641 338376 9636 3665 8717 56832 8772 56919 8737 4938 6041 4283 3586 3458 3459 4843 6373 1535 25828 79792 3627 3134 10135 1536 10628 5371 340061 4940 834 115361 684 3606 2634 4939 9447 107181291 90865 2635 114769 91543 7158 10399 103 54115 6772 3716 10379 7297 6773 100129543 3572 3717 6774 4599 8638 1965 3434 PMC8063300__F1 Aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications 196 9049 5970 5971 405 3550 1543 1728 PMC8063416__F2 Still’ disease interactome a considering all disease effectors and their direct interactors and b focusing on disease effectors and their interaction to drug targets, and comparison to c pathway enrichment results of sJIA gene expression data 54106 9021 51284 3624 8809 59067 3162 51561 3440 3606 5468 1431 3593 3569 10068 4684 3596 3565 3559 140 3146 4790 5970 3459 3605 356 1435 3553 355 3576 6376 4615 4314 8878 4068 3627 6373 720 717 713 712 3500 6280 9474 6283 6279 4284 201294 5873 9436 9437 PMC8063501__F2 DSB repair pathway choice 286257 55183 149840 112441434 54537 7518 3981 142 5426 5893 3978 9156 672 675 5888 PMC8064355__F7 Schematic illustrating the suppressive effect of 6M3HSC (compound 3) against the RAGE-RAGE ligand signaling pathway 3146 717 1729 114609 85440 4615 3654 6010 998 5879 PMC8064692__F2 NRG/ErbB signaling and downstream signaling pathway 7039 1950 1839 10718 145957 9542 126669 2885 867 572 2475 2064 2065 2066 PMC8065646__F4 Redox targets within insulin secretory pathway and proteins involved in extracellular redox signaling 100170220 57716 339855 50507 7220 727 7224 59272 6868 29843 PMC8065873__F1 Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery 7422 7424 7852 6714 8942 998 3014 6774 5111 2475 581 407040 6667 1017 1786 6935 999 PMC8065873__F5 Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery 3553 1956 8205 1636 857 999 1236 1000 6774 983 1431 5340 2833 3383 7412 6120 PMC8066025__F2 Indirect antiviral activities of PARPs through immunomodulation 3458 84875 10010 54625 64761 3661 6778 83666 151636 57097 PMC8066746__F3 Schematic model of “Common Pathways Underlying Drug dependence” is an output (FDR p < 0.01) of the Wikipathway functional pathway analysis 5566 5894 107 5906 5567 369 5568 2890 2891 2892 2893 60 5499 2911 5579 5582 814 1385 1815 1812 1813 PMC8067602__F4 Necroptopic signaling pathway 7186 8717 8772 197259 PMC8067938__F1 Hippo signaling: bridging the gap between cancer and neurodegenerative disorders 23513 7791 84962 166824 83593 83937 11186 9770 4485 26524 9686 4771 60485 80014 23286 122786 4609 1869 374 PMC8068079__F2 Base excision repair, nucleotide excision repair and mismatch repair pathway 142 5423 5426 5428 7508 5111 PMC8068766__F4 Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells 2475 1854 1577 2799 8914 10714 10670 3558 84296 51514 11001 64121 23595 4999 79019 83461 2113 6678 6418 2353 PMC8070209__F10 Pathway involved in the synthetic lethality of PARPi with combination of cisplatin on Twist knockdown CisR OC cells 22926 581 7515 836 842 PMC8071398__F2 Classic signaling pathways activated by GnRH 1950 2798 1956 6714 5894 2002 2488 PMC8072122__F1 Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways 5728 2475 1499 283120 100885779 4040 4041 324 100302142 4193 PMC8072665__F4 Identification of the Key Role of NFKB Signaling Pathway in the Treatment of Osteoarthritis With Bushen Zhuangjin Decoction, a Verification Based on Network Pharmacology Approach 1432 7422 860 3757 4353 6517 7056 2920 2353 929 6696 4312 1277 4129 1870 5742 3929 890 4319 9332 4313 3162 5118 5327 6401 4953 239 1504 4609 79400 6651 8972 2946 847 2891 9429 1147 4772 4133 2805 598 3091 154 2936 595 3659 581 18 5468 2194 1017 6373 3627 5579 8626 347 6590 213 10598 2152 PMC8072665__F5 Identification of the Key Role of NFKB Signaling Pathway in the Treatment of Osteoarthritis With Bushen Zhuangjin Decoction, a Verification Based on Network Pharmacology Approach 51182 7532 2885 203068 9349 10598 1387 6223 6189 6128 713 7531 1938 6119 2091 6188 7316 4691 6169 7415 6667 3091 1213 367 3725 6137 6205 6201 6208 6187 3608 2597 6202 4904 1660 6117 4627 11140 2335 672 10528 9584 6160 6203 7284 10856 2521 4193 9924 7157 5970 4609 6232 3609 2099 9188 2033 207 60 8726 4869 983 4116 51547 5315 7428 22938 6627 2147 10576 5371 51474 5111 4000 351 5591 2316 2146 3068 1017 10155 5594 6418 8850 648 5925 1616 5058 4171 2648 PMC8072960__F3 Androgens and Androgen Receptor in Human Bladder Cancer 1977 4314 367 3579 3577 3717 6716 4322 4312 PMC8073701__F5 Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer 5105 5430 56954 1081 49854 3131 1390 1385 466 4800 7097 10333 7096 283629 7018 1386 8538 11016 4783 9757 2033 84699 1051 1387 200186 7157 7187 3066 3725 1956 6662 PMC8074203__F3 Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights 7099 3795 114548 22926 355 3606 29949 PMC8076345__F3 Differentially Expressed Protein Interaction Network 10810 394 1012 37 51726 9601 192111 18 8936 5058 501 9844 56947 5095 1008 4129 1892 23193 51024 51116 2776 5198 1630 221 6714 28988 1627 90480 5589 10130 1471 27034 51382 140885 2787 3704 64928 471 3417 9495 427 375056 9550 336 2550 10657 5816 816 10989 1272 271 4048 30011 25813 230 4897 5297 6237 954 6430 54205 7086 64856 25977 274 8867 5226 5728 55749 3337 793 87178 783 5211 781 1537 5878 9892 29924 79837 118 5718 9610 3306 784 143187 6628 51762 374291 6426 4712 4728 9341 120 3313 7249 6843 8775 7112 6196 4695 10469 4713 51560 51164 63908 10613 55066 3151 4001 6637 25782 8615 7415 11240 6710 3150 1020 10419 10652 5792 6917 2729 832 23395 84364 9867 142686 8499 5160 286 5036 2936 23376 4200 287 10873 10616 6223 9588 114088 8924 25831 3945 1540 92935 8662 23438 7965 6207 1977 57176 8666 1975 PMC8076903__F1 TRP Channels in Brain Tumors 2670 7442 467 59341 5879 145258 7220 79054 6010 1950 3082 6420 51393 7225 64781 995 355 54822 3717 6774 3479 8989 90550 7416 80036 5908 7226 PMC8077955__F2 Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease 7099 3569 7124 3603 3479 10461 PMC8080614__F1 Glutamine metabolic pathways 2806 440 3418 27165 2746 84706 5471 1356 3417 PMC8080978__F3 GO and Pathway enrichments of the PPI network 4609 5228 4053 405 351 64399 6885 285704 27160 27063 23768 796 5743 79633 81848 867 1756 1399 2066 7422 602 10938 9076 7124 9630 977 7128 10404 8527 9586 8356 10672 23186 3569 4097 1051 50808 330 904 942 6757 5728 2115 3552 3021 2202 PMC8082541__F1 Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue 7442 23411 63976 5465 79054 1386 1734 7350 PMC8083443__F1 Immunohistochemical analysis of Nuclear Factor-kappa B (NFKB) between follicular and plexiform ameloblastomas: A pilot study 3952 5447 4049 4050 613 6850 4067 929 7187 4055 27040 29760 4609 8717 114609 1540 1610 331 4351 PMC8083961__F3 Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration 23411 7465 983 3480 3479 1977 5163 2475 207 2066 2064 6722 PMC8085490__F5 Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma 8975 6888 3418 8802 4609 5211 4191 54602 8343 257000 102288414 55206 581 6794 23410 2309 2806 4704 55902 3158 5224 5160 47 7351 1002 5209 33 23417 2744 1373 5009 1356 5106 23409 2539 6647 23408 PMC8085809__F2 Microbiota signalling to the host circadian and metabolic systems occurs via both contact-dependent mechanisms and contact-independent mechanisms 50616 4771 355 5697 PMC8087647__F1 Machinery of canonical and non-canonical autophagy 8408 9776 60673 22863 55626 7405 10533 64422 26100 9140 PMC8087647__F3 autophagy in immune cells in the tumour microenvironment 8205 9776 8408 596 27161 383 7939 60673 384 23152 4609 50943 PMC8087671__F2 Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes 1101 23600 1628 570 5264 9409 8504 30 5830 5190 5189 55670 11264 4358 5827 7448 80144 341640 158326 283927 83594 1610 390916 183 55825 8528 54677 1384 23417 5828 5192 5193 4598 10654 51268 3155 196743 8540 5805 5191 7450 1758 1832 5195 5194 847 5052 25824 2053 373156 7498 10901 960 948 961 PMC8087671__F3 Proteomic and phosphoproteomic profiling of shammah induced signaling in oral keratinocytes 7124 8737 220 7186 9825 8772 1540 355 7099 7098 142 3014 2821 5315 128 27005 11035 7167 596 81030 5214 2597 5230 581 54822 197259 2752 5836 5008 3939 3945 2746 114548 834 4015 90865 3146 PMC8088752__F7 Integrated stress response-mediated activation of mammalian RNA-dependent mRNA amplification 468 22809 1998 9812 115209 PMC8093191__F1 miRNAs affect animal behavior related to MDD and BD by regulating the expression of genes involved in serotonergic neurotransmission and signaling pathways activated by glucocorticoids, BDNF, Wnt, and guidance cues 6804 3350 2932 2289 324 1499 23411 6446 5728 627 1843 1630 387 PMC8093449__F5 In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention 3736 3760 3762 3763 3770 51393 7442 2550 2770 6714 673 5595 43 9568 774 1385 140679 6616 2571 6571 814 PMC8096095__F5 SRI-21979 alters the expression of transcripts involved in cAMP signaling and apoptosis 7124 10257 109 134 355 2778 2768 1616 8772 6101 801 808 1508 1514 7186 5566 472 598 596 843 7410 64411 5605 836 840 835 5879 2021 387 5595 10488 6662 5058 6010 572 268 4000 7157 581 8739 PMC8099789__F1 ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients 59272 367 6868 1636 545 5340 PMC8101191__F2 Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression 6774 5971 102 6925 960 5579 942 6657 PMC8102340__F1 Project flow chart summarizing analyses and key results 339855 84232 10610 54549 28962 51332 161835 2045 169044 4854 6718 23331 55166 11116 2124 10924 2719 9 390442 387263 6118 5591 2073 1161 PMC8102595__F1 Effect of plane of nutrition in early life on the transcriptome of visceral adipose tissue in Angus heifer calves 22933 10533 650 4086 9575 2303 1959 59343 5947 23175 9242 10682 1050 1499 2146 1879 3952 2167 4023 51274 1487 1488 9869 55294 26580 PMC8104092__F7 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication 5894 2002 695 5091 156 1445 2932 PMC8105340__F9 Endovascular progenitors cell fate 5727 2735 5156 6662 3516 1003 947 3280 23462 PMC8105803__F6 Map of PI3K/AKT/mTOR signaling pathway regulated by the LEP gene drawn through the KEGG database 759 472 545 637 4609 842 4193 64065 84883 5728 7249 PMC8109088__F8 Proposed model illustrated the role of hsa_circ_0110102/miR-580-5p/PPARA/CCL2 signaling in regulating HCC metastasis 619501 729230 5465 6347 PMC8111986__F5a Identification of an immune classification for cervical cancer and integrative analysis of multiomics data 7531 7170 4117 5328 6935 8323 1591 2335 PMC8113651__F1 HIV-1 modulation of autophagy during early infection and viral non-productive bystander cell contact, and in persistent infected cells/tissues 382 57521 920 2475 664 9474 10533 100187761 8678 5195 847 PMC8113849__F1 Estrogen and estrogen receptor-mediated pathways in thyroid cancer 7471 1956 8660 5266 5894 1499 8826 5728 50507 2475 10626 PMC8117355__F1 Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer 60674 1874 121838 1356 142 6772 112597 154860 100124700 101927597 283131 5820 652995 4232 2821 230 226 55384 100874054 648 2146 7428 102723099 9055 867 355 1026 7832 171022 7077 728978 57447 4690 PMC8120650__F3 Autophagy-related signaling pathways are involved in cancer (Review) 6446 5355 5163 5728 253260 2475 64223 64798 4609 2309 6009 388228 664 7248 7249 PMC8122967__F1 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks 2885 54956 5156 5163 23411 7465 5728 81847 367 4097 8717 7424 595 7186 7296 2877 329 330 331 596 598 5934 637 8772 2002 8505 5608 5595 317 4282 PMC8122967__F2 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks 6741 10039 200558 472 55183 2237 7515 7507 1643 3980 672 7508 55505 4361 7012 8505 675 5888 25913 PMC8122967__F3 PARP Enzyme Family and the Hallmarks of Cancer Part 1. Cell Intrinsic Hallmarks 2194 8658 8505 5728 23411 142 10038 80351 84875 5163 5226 2539 3417 4097 4199 7249 7248 54625 3098 253260 6009 2475 7428 8408 3099 3939 2597 3418 2744 PMC8123490__F4 Metabolic Spectrum of Liver Failure in Type 2 Diabetes and Obesity: From NAFLD to NASH to HCC 7038 5465 7054 4017 729230 1234 PMC8125073__F5 Oral Epithelial Cells Distinguish between Candida Species with High or Low Pathogenic Potential through MicroRNA Regulation 1978 286 287 50943 8648 7431 2821 1977 3091 405 2475 6194 6303 10399 8453 6921 9978 6923 5315 4843 147 3162 1490 133 4193 23028 1356 3481 7039 PMC8125483__F1 Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models 5894 5971 6850 64170 10892 3732 3603 114548 3606 7097 51338 3458 PMC8126328__F1 G-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma 9513 9100 5528 1982 5580 253260 10298 7248 7414 4691 7054 1981 6194 5562 2475 6418 7249 84335 5584 5515 1969 301 5578 857 7094 1386 27044 2317 4627 6181 26058 9584 91624 57521 3725 51552 2887 9209 1956 5605 3320 200186 5581 858 25 2060 6714 5894 3326 5209 81 2316 5062 2318 4638 5058 5829 4690 10627 2909 29924 1435 4659 PMC8126563__F2 Protein kinase CK2: a potential therapeutic target for diverse human diseases 23237 4193 637 83939 11140 5371 2735 9429 PMC8129117__F6 Proposed model of ROS generation and regulation of survival signals in CLL cells 613 4067 558 695 2475 6648 PMC8129546__F2 Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway 4609 1800 5970 6352 6347 3717 2688 3569 3480 3606 7056 5468 4314 2475 7124 847 836 2784 5444 5465 23411 4306 367 4128 5595 3586 9429 841 3356 2169 7498 51094 3037 PMC8130833__F1 Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma 472 7157 545 PMC8131834__F2 Targeting Parthanatos in Ischemic Stroke 23411 5091 64853 PMC8134690__F1 HIV Nef-mediated Ubiquitination of BCL2: Implications in Autophagy and Apoptosis 10155 596 8678 7189 286827 51127 4591 684 55626 PMC8137523__F1 Inhibition of the mevalonate pathway by statins affects several outputs and lipid-regulating transcription factors 29914 3652 57107 23590 6010 9453 47 4553 55902 3157 3156 4598 10654 4597 2224 3422 2222 3638 22937 3949 116150 PMC8138124__F1 New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response 472 9656 1153 2521 142 9025 55135 672 165918 3065 6419 27339 9782 27316 10432 4841 6421 100187761 641 1763 9156 675 79728 8487 5888 PMC8138161__F4 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway 9474 10533 894 581 PMC8138161__F5 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway 2475 9474 10533 581 596 PMC8139654__F11 Microfilaments and Microtubules Alternately Coordinate the Multistep Endosomal Trafficking of Classical Swine Fever Virus 387 1956 998 5879 6093 3984 5058 3916 PMC8144889__F2 Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension 10125 5741 6446 1848 65125 65266 26249 8452 130497 PMC8145311__F7 Distinguishing Alzheimer’s Disease Patients and Biochemical Phenotype Analysis Using a Novel Serum Profiling Platform: Potential Involvement of the VWF/ADAMTS13 Axis 51008 9640 55689 54815 143 3514 91653 1540 6645 476 682 9181 8570 23524 1378 55183 825 128553 56144 4038 102724631 7128 3339 7450 4052 2896 3689 100996331 3687 4035 1958 10664 11093 116986 26019 5459 64478 2138 9644 27163 4053 PMC8146344__F1 Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts 2335 3569 4087 4088 59 5136 3091 4313 7076 4318 1277 1281 7804 4485 9113 26524 4015 PMC8147076__F1 Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events 9049 196 405 PMC8147372__F6 Transcriptomic and metabolomic characterization of post-hatch metabolic reprogramming during hepatic development in the chicken 5214 3101 2645 5213 5211 2821 2597 3945 3939 5230 669 5223 92579 2539 57818 5091 5132 8277 6888 2271 6390 6389 6391 6392 4118 25796 1737 5160 5162 1738 1431 11113 729020 22934 5631 5634 3419 4967 PMC8147889__F3 Mechanisms of HBV-Induced Hepatocellular Carcinoma 1499 4040 4041 2885 324 6774 595 2549 9846 3667 5163 9817 2308 4094 5728 PMC8150330__F1 Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics 8829 59272 5045 7113 22848 2580 PMC8150642__F2 KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism 355 95 2181 3939 3418 2744 2806 47 84164 3417 4190 PMC8156203__F3 Targeting Reactive Oxygen Species Metabolism to Induce Myeloma Cell Death 2539 3099 5723 29968 26227 2026 2020 3939 2744 PMC8156237__F4 Do Autism Spectrum and Autoimmune Disorders Share Predisposition Gene Signature Due to mTOR Signaling Pathway Controlling Expression? 551 2353 367 929 6891 4214 8741 3667 1432 4790 3479 4792 3133 8021 6955 2638 3112 6256 7284 6938 8829 861 2321 3416 3952 9846 7157 27040 5728 2475 1535 3953 7422 3630 847 1401 PMC8159759__F1 Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases 7099 10392 948 10011 114548 4088 7097 64127 PMC8160027__F2 Vital role for nitric oxide in intraocular pressure homeostasis 115677 51070 857 5335 PMC8160894__F6 TAK1/AP-1-Targeted Anti-Inflammatory Effects of Barringtonia augusta Methanol Extract 7099 4615 5595 6347 PMC8161379__F1 Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy 9350 1674 56848 8877 6611 64781 95 PMC8161962__F5 Persistent Newcastle disease virus infection in bladder cancer cells is associated with putative pro-survival and anti-viral transcriptomic changes 5653 8313 1947 8190 51176 9076 3625 389058 999 1160 1000 6513 5587 2034 85407 384 1001 6659 2744 2697 55959 57214 9965 10253 10553 PMC8164819__F5 Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance 2735 2736 3065 4041 324 1499 22943 11171 23512 3280 PMC8170311__F1 Metabolism in the Development of Personalized Therapies in Acute Myeloid Leukemia 948 2322 4869 6510 2146 8140 PMC8170620__F2 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection 100124700 128338 581 6774 10783 55384 406915 100302237 2309 84708 PMC8170976__F9 Parkinson mice show functional and molecular changes in the gut long before motoric disease onset 4747 8774 475 6863 10590 7335 794 10093 23336 7168 310 1264 6844 5798 10540 PMC8171373__F1 Hijacking the Pathway: Perspectives in the Treatment of Mature T-cell Leukemias 4193 472 4170 1043 596 581 3702 PMC8171374__F1 Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments 7173 50615 958 29851 1378 940 941 942 PMC8185863__F2 Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma 29128 4088 4087 4089 4092 27161 22943 1499 324 100126306 6651 8453 PMC8192181__F5 Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NFKB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways 3717 6774 7124 3603 6348 6352 3627 PMC8192774__F3 Differential methylation of G-protein coupled receptor signaling genes in gastrointestinal neuroendocrine tumors 319100 55303 9038 613211 245939 169522 140881 7881 134860 9287 613210 8875 8876 9254 339403 5368 1893 5345 2770 6750 5473 5816 2993 2147 319101 2626 58 57105 112802 4060 2875 7201 1281 3854 1084 140885 634 2562 403314 10622 8309 55825 5435 8725 PMC8196557__F6 miRNAs and Genes Involved in the Interplay between Ocular Hypertension and Primary Open-Angle Glaucoma. Oxidative Stress, Inflammation, and Apoptosis Networks 4650 8997 7040 1634 10395 3569 11214 2059 998 7049 7045 2200 717 718 2668 462 2147 2817 1284 7422 858 5747 719 1630 3685 3371 51378 1285 1287 1290 3913 3690 3673 1289 1277 22801 3694 1301 1583 7867 6867 26060 7057 7010 23424 1409 23770 842 836 596 56616 1296 1302 317 598 840 835 1278 4323 2620 948 4313 27113 63970 7157 4193 207 4194 355 5925 3659 9962 1611 60312 1690 7187 4976 2296 80173 54739 9774 4016 8626 6495 28981 55616 729 8636 5076 2199 81794 6678 118856 11016 1415 2301 4653 7837 2006 10133 1545 2922 583 5737 220202 57728 56912 253827 7148 5080 23786 55764 10585 57096 4326 23237 26146 7173 134430 3092 4990 4320 2202 2201 646960 4053 2879 4133 9479 7042 PMC8197470__F1 Advantages and Disadvantages of Different Treatment Methods in Achondroplasia: A Review 5741 2261 1267 PMC8197596__F1 Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again? 5970 4323 1499 54585 348 4312 23411 4851 59272 PMC8198029__F1 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer 3606 3845 3458 2956 30009 4282 4851 2113 50616 2064 207 29126 2146 6929 5716 9370 6197 10397 6935 2069 1045 3958 4072 1950 110806272 3516 3084 1044 9536 5290 2697 8607 7039 2303 225689 79923 324 467 55818 23028 57521 10980 208 7057 23463 5291 8817 407975 5916 3485 5329 1630 374 PMC8198029__F3 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer 3659 673 3605 5579 1029 3592 9314 5371 6774 56616 3558 7422 2950 4582 4773 2305 960 6850 7048 595 9021 6662 5743 8743 6714 1499 6095 3553 6778 7442 3565 3091 1386 3596 50848 3146 4638 4615 3578 5580 5584 3569 5747 11315 PMC8201163__F1 Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications 2876 847 31 2194 3156 5465 3667 335 7099 7124 PMC8202022__F5 Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease 3606 4583 5970 7097 7099 3689 3684 3459 4513 3315 201633 920 3553 3569 836 3586 3588 1499 4843 3726 2353 PMC8202879__F7 LncRNAs induce oxidative stress and spermatogenesis by regulating endoplasmic reticulum genes and pathways 7018 6667 847 7296 2729 1536 2876 2878 54578 5447 7498 4784 1543 PMC8203646__F8 Meta-analysis of gene signatures and key pathways indicates suppression of JNK pathway as a regulator of chemo-resistance in AML 57161 114548 3553 3606 5163 64411 PMC8204249__F3 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms 7124 8717 8772 841 11035 197259 PMC8206782__F3 Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 Patients 59272 7099 51311 51284 2475 3661 3665 3458 4117 81030 79792 PMC8207832__F2 Ubiquitin-dependent protein assembly at DSBs and their roles in DSB repair pathway choice 55183 672 83746 9656 9817 79728 9025 472 675 51444 9156 55159 5888 1763 8237 29128 PMC8218506__F4 Cornuside I promoted osteogenic differentiation of bone mesenchymal stem cells through PI3K/Akt signaling pathway 29127 55355 9133 11004 332 2305 10403 991 701 983 699 1063 891 55143 79682 55839 113130 64105 152 54908 91687 220134 57007 79019 55055 11130 83540 2921 2920 6372 6352 1901 1058 718 9833 2861 9568 9735 57405 5660 81930 24137 1062 3576 259266 7272 51203 3832 6790 25906 55872 10112 7153 10615 22974 9787 890 64151 9493 55165 27338 9055 4751 56992 26118 55819 29116 6241 899 51191 221687 64750 90293 PMC8221295__F6 Mechanistic insights into the anti-depressant effect of emodin: an integrated systems pharmacology study and experimental validation 1890 1559 5604 1557 5605 2263 7422 6647 2260 3553 3586 207 7124 3558 1385 2932 3479 5728 5594 3569 3845 3630 PMC8222109__F1 Inflammatory Profile in a Canine Model of Hypothermic Circulatory Arrest 2002 7189 3716 10454 7133 7186 3315 4791 5606 9261 22800 3265 6722 2885 3717 6774 1401 2 8651 9021 4170 5288 5289 PMC8222490__F2 Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue 1277 10319 1101 5649 1311 2335 6696 3672 3688 3673 3675 3676 3678 3655 3679 7448 3371 255743 80144 158326 8516 3680 8515 22801 3685 3695 7450 3381 1758 1832 3690 3674 3693 3694 3691 375790 3339 960 6382 22987 948 2814 2811 2812 2815 51206 1605 961 3161 PMC8222783__F1 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway 2534 6850 8915 84433 974 973 4067 640 613 10892 54106 29760 5336 4615 695 51135 7189 3707 930 4893 3845 673 2782 2475 PMC8222783__F3 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway 2534 8915 6850 84433 613 974 973 4067 640 10892 54106 29760 5336 4615 695 51135 7189 3707 930 4893 3845 673 2782 2475 PMC8222901__F2 Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity 64127 114548 8717 7186 7188 8767 11074 135644 5987 56658 7099 58509 4615 7189 23118 10475 7726 7098 7187 29110 3661 57506 80352 PMC8224166__F1 Microbial dysbiosis in carcinogenesis & cancer therapies 3569 3596 999 1499 PMC8225085__F4 Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2 5243 9429 8745 596 672 675 8900 894 898 1017 1435 1474 1509 1956 2625 3090 3397 3486 3725 3875 3880 4255 4292 4313 4318 4609 4830 2908 29108 5915 11186 5054 2810 7033 9575 1101 PMC8226258__F5 X-Inactive-Specific Transcript: Review of Its Functions in the Carcinogenesis 960 9314 9429 999 9839 7471 1499 7503 100187761 80312 4322 4318 PMC8228183__F17 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology 7040 2247 50507 27035 PMC8228183__F20 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology 50508 27035 79400 50507 53905 50506 PMC8228183__F22 NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology 50507 4313 1977 27035 5465 5058 5163 3566 3565 6774 3717 79400 PMC8229353__F1 Opposed Interplay between IDH1 Mutations and the WNT/Beta-Catenin Pathway: Added Information for Glioma Classification 2932 4040 4041 324 1499 595 3939 6774 PMC8231117__F3 Irisin in Cancer Disease 999 6774 1000 2475 PMC8231510__F3 CUT Domain Proteins in DNA Repair and Cancer 252969 5423 3980 4350 3978 PMC8234227__F4 Natural Phytochemicals Derived from Gymnosperms in the Prevention and Treatment of Cancers 355 8772 22926 7494 7186 2475 8408 637 581 PMC8234271__F2 MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma 1956 2260 5979 867 5781 5879 2064 2263 6098 54206 2065 2261 238 3845 5594 2066 2264 2322 6654 3265 369 5604 3815 4914 4763 673 5156 3480 4915 5921 6016 PMC8234490__F8 Ergosta-7, 9 (11), 22-trien-3Beta-ol Interferes with LPS Docking to LBP, CD14, and TLR4/MD-2 Co-Receptors to Attenuate the NFKB Inflammatory Pathway In Vitro and Drosophila 3929 929 7099 4615 114609 3553 PMC8235304__F1 Opportunities for Ferroptosis in Cancer Therapy 2182 6520 23657 2937 2730 2729 2879 3156 3652 PMC8235534__F1 Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update 2147 2597 3939 5091 47 5105 355 5106 PMC8236109__F2 Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net 1956 675 672 2305 990 993 595 PMC8238150__F1 (Pro)renin receptor in the kidney: function and significance 359 551 183 4040 4513 219972 PMC8238154__F8 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells 1052 5154 4853 4086 2305 4087 5155 23286 9159 6760 10013 7157 196 7832 23082 2919 4851 467 3399 6095 10379 1513 2146 468 3576 4791 2308 4792 3661 1054 8848 6376 55922 4193 1029 4899 2274 4312 25825 10370 26471 6347 5468 4316 1031 9935 6367 1803 2113 8085 3621 PMC8242058__F6 Endoplasmic reticulum stress, chondrocyte apoptosis and oxidative stress in cartilage of broilers affected by spontaneous femoral head necrosis 9817 468 847 83939 22926 7494 596 9474 30001 836 842 841 637 PMC8249877__F1 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development 6714 9780 6010 5784 7424 4485 9113 4771 154796 PMC8250230__F5 An Integrative in silico Drug Repurposing Approach for Identification of Potential Inhibitors of SARS‐CoV‐2 Main Protease 3569 6347 3576 6348 3553 5199 59272 367 PMC8252888__F9 GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway 998 2475 581 PMC8253910__F5 Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis 79837 25874 11283 112817 55347 2109 5467 50 1543 57704 80150 4259 1666 3081 5465 55471 1376 131474 23576 81693 79641 151393 6257 6256 2539 8761 6144 6432 6727 8607 387775 259282 259217 6519 51110 5682 5468 3026 2017 2060 84898 64122 7353 6258 2547 6189 3988 3241 100287171 9100 55230 54825 4311 525 113230 80006 10891 23136 PMC8254604__F2 Key Signaling Pathways in Psoriasis: Recent Insights from Antipsoriatic Therapeutics 9817 466 7186 7189 10682 6774 149233 196 405 PMC8255141__F4 Age-Dependent Sensitivity to the Neurotoxic Environmental Metabolite, 1,2-Diacetylbenzene 54210 834 838 3553 7099 4615 7124 340205 PMC8255319__F2 Molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives 3949 3939 3099 3098 2194 3156 6120 22934 6646 4199 2673 47 4190 7157 3845 8140 8501 PMC8258627__F1 Advances in the role of autophagy in the development of retinoblastoma 2475 8408 9140 9474 7942 PMC8261167__F1 Emerging mechanisms and targeted therapy of ferroptosis in cancer 8314 467 23657 6520 875 1491 2744 2937 6510 81539 2879 PMC8261167__F2 Emerging mechanisms and targeted therapy of ferroptosis in cancer 2879 3156 5447 2643 4015 100 10162 9817 8031 2182 3658 7018 3315 PMC8261167__F4 Emerging mechanisms and targeted therapy of ferroptosis in cancer 27198 3458 3716 2879 23657 6520 3845 3146 177 6774 383 7040 PMC8263635__F11 ELOVL2: a novel tumor suppressor attenuating tamoxifen resistance in breast cancer 79068 2078 7040 90427 5163 54898 117145 64223 60481 8205 PMC8264285__F2 Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment 5728 2885 5539 1950 1380 2475 1499 572 2932 2308 596 842 6010 6667 PMC8267469__F7 Systems Pharmacology–Based Dissection of Anti-Cancer Mechanism of Traditional Chinese Herb Saussurea involucrata 7124 3569 4049 3570 6714 6774 7186 7187 2475 572 842 6256 4193 4513 6194 1950 PMC8267928__F3 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction 83666 358 5538 6493 2242 11274 4600 948 19 3431 717 57506 10965 13 1491 6773 6497 11035 5329 5967 791229 1408 6652 PMC8267928__F5 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction 81788 6772 3918 56241 2980 56954 6241 2526 2938 10249 84951 7520 7031 4129 5329 339221 7104 26499 951 4585 308 6890 4258 57214 56848 1535 163786 1043 1908 57549 7378 55601 274 10553 91663 11262 2122 54739 54517 26040 388403 55512 56034 5465 4199 130120 11035 4257 6652 13 6689 5698 145957 948 5166 7048 10673 6720 19 2695 963 4843 4600 6610 10930 134285 2889 PMC8267928__F6 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction 5817 7052 5538 57506 837 6773 9450 358 4939 80149 6498 79132 11274 1491 6890 3627 4600 4843 963 30835 3431 6689 19 5019 6648 4929 23410 7849 8741 145957 5329 4199 191 2122 5465 6652 7378 81030 4153 116071 22949 5328 54546 1408 134526 641371 PMC8267928__F7 Immunity Depletion, Telomere Imbalance, and Cancer-Associated Metabolism Pathway Aberrations in Intestinal Mucosa upon Short-Term Caloric Restriction 6241 2937 2948 2877 2947 7486 373156 6839 10397 7520 2946 5209 2938 2941 4257 1728 2944 2939 4843 4258 2940 5465 6720 19 5105 5597 10891 5932 2052 23410 PMC8268514__F1 Review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations 2885 6714 5879 998 5728 4193 2475 572 PMC8268744__F1 Structural and Drug Targeting Insights on Mutant p53 545 472 581 596 598 332 317 355 1647 1026 2810 983 891 995 4193 5371 5054 2176 4436 1643 7508 57103 27165 6513 6517 2876 9997 5209 9131 407040 780 7852 7422 10533 8678 55332 PMC8269088__F1 Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets 613 6850 4067 2534 29760 695 2475 6774 2885 7096 7097 10333 7100 7189 4615 51135 3656 3654 4118 3663 3661 7187 PMC8281348__F9 Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells 9242 387 4163 9113 26524 22943 558 27063 9344 51347 57551 4485 60485 9049 PMC8283010__F3 Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation 6955 7186 999 7124 4314 5340 3553 1051 PMC8283767__F2 Non-coding RNAs in Alzheimer’s Disease: From Regulated Mechanism to Therapeutic Targets and Diagnostic Biomarkers 283131 100379571 494333 351 105751187 4170 406928 3479 465 55384 8877 693198 627 1956 56852 PMC8284093__F10 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney 1869 4609 472 545 581 10572 94005 84883 1017 914 64065 7249 5728 637 4193 64326 842 836 5054 PMC8284093__F11 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney 8295 5458 133746 3066 4193 6597 7159 57060 2033 1387 604 6890 581 665 2232 892 9448 22943 10983 25946 3663 1434 5925 3276 2876 7306 3732 79370 93624 8793 317 5457 5111 5054 80781 5564 50484 3090 2810 639 27244 4313 599 2648 467 597 6880 7161 3304 596 5366 1843 5371 10153 54541 7157 25898 28984 3064 27113 4292 1956 3303 4436 3725 84883 1847 174 6667 1969 3169 7832 1655 3311 637 355 8795 4802 94241 3486 834 55367 4170 7039 5395 578 839 3082 324 4801 7421 54487 29102 1869 10397 1820 891 857 1263 4800 57103 8626 255488 1643 1509 51499 64065 55800 7027 843 8797 7249 5728 6696 4068 1907 333926 3976 1870 1871 PMC8285010__F1 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARG in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol 5465 3158 335 4199 1581 1582 4023 4973 5360 7350 3611 7316 4312 5163 364 PMC8286839__F6 Canonical and non-canonical NFKB signalling pathways 8717 7186 7099 598 10487 10486 5971 PMC8290830__F2 Autophagy in hepatic fibrosis 1788 79065 3146 2475 8408 79868 10533 9474 9140 PMC8292968__F2 Non approved pharmacological targets and interaction of selected profibrotic pathways in SSc myofibroblasts that are currently being evaluated in clinical trials 3716 3597 7297 3717 6778 4018 6010 6722 57591 57496 6774 6714 50507 4157 PMC8295173__F1 T cell metabolism drives T cell fate and function in to eliminate tumors 940 383 1493 324 941 942 PMC8297972__F1 Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease 4512 2358 90865 PMC8298499__F6 Untargeted Metabolomic Profiling of Liver in a Chronic Intermittent Hypoxia Mouse Model 7018 1356 6520 5621 5094 55240 2879 8031 100 PMC8301451__F1 Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer 4091 4090 4086 4089 4087 4088 5494 3725 7124 85451 PMC8301816__F2 Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers 999 1499 857 1950 1956 8556 6935 3479 3480 6774 6714 PMC8304173__F2 Therapies Targeting Metabolic Pathways in Cancer Stem Cells 4211 4609 2821 226 2023 3845 2539 PMC8304173__F4 Therapies Targeting Metabolic Pathways in Cancer Stem Cells 2194 95 11000 1375 1376 6774 47 240 PMC8304747__F5 Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration 64802 349565 23057 50943 PMC8304872__F7 Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis 84876 6786 7494 3146 8737 11035 8772 841 3014 790 842 836 PMC8305424__F3a Genomic Approach to Delineating the Occurrence of Scoliosis in Arthrogryposis Multiplex Congenita 28964 5829 7414 3929 2316 387 324 2335 7204 1398 2934 2885 1950 55970 998 10458 PMC8306340__F5 Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC 602 11331 5970 4791 9770 3606 23198 5701 6885 23118 7187 5688 9516 1896 5685 5713 6188 3551 9020 1147 4790 2033 9641 8517 8877 7186 5715 4049 10913 8205 1540 7054 7412 4513 PMC8306599__F2 Advanced Glycation End Products: New Clinical and Molecular Perspectives 3717 6772 3716 7412 PMC8306787__F4 Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance 283120 378938 55384 440823 200186 3172 468 355 5091 4017 PMC8306901__F5 Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma 1493 5728 4193 5163 5164 2475 867 3815 4893 3845 4763 PMC8306961__F3 Arginine Signaling and Cancer Metabolism 2932 2475 2000 9927 7004 468 1998 440 PMC8312441__F7 Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma 64403 1015 56129 1014 8642 1012 92211 983 1163 1164 1005 9134 54798 993 9088 1869 9133 5933 64072 54825 7465 7027 891 26025 5934 1874 1017 1027 8900 1026 898 5962 60437 56131 65217 1870 7029 4771 PMC8313979__F3 Systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis 1386 10905 4245 122953 84002 639 8703 1106 148327 3340 4204 92126 9469 50515 10090 55790 4208 3662 3663 864 7903 2313 6489 8128 6934 2526 2529 7054 23394 4261 6480 4782 4249 7018 PMC8316858__F8 Investigating the Pharmacological Mechanisms of SheXiang XinTongNing Against Coronary Heart Disease Based on Network Pharmacology and Experimental Evaluation 5163 572 842 836 581 PMC8317057__F4 Pathogenic Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Possible Mechanisms for Immune Evasion? 3661 7098 4615 7706 3383 6347 6774 7297 3717 595 4928 6773 367 6667 PMC8319838__F4 Temozolomide resistance in glioblastoma - a comprehensive review 4041 324 6925 51701 1499 PMC8324677__F1 Stress kinases in the development of liver steatosis and hepatocellular carcinoma 3667 9611 5465 5879 581 26291 51 1962 2171 PMC8326121__F6 Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives 1956 100507098 324 100303491 102800310 647979 103352670 100507246 5820 106144538 PMC8326261__F3 Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility 7392 7391 7097 54106 7124 2919 6348 1386 4615 PMC8326438__F10 Exploring effects of DNA methylation and gene expression on pan-cancer drug response by mathematical models 84330 91768 9886 54664 25798 8899 7057 84532 1645 196528 1601 166012 5089 90 155382 6009 5587 387 7022 1605 11019 5792 7049 55023 26353 3321 27079 10882 5411 29015 337876 1500 51421 80210 394 10664 29933 53335 11030 4035 7466 5640 10691 54972 6850 5880 8714 80255 51199 84978 166614 2495 2059 2271 85358 9535 3183 51232 57522 7220 64285 9341 83593 5742 57475 8996 8773 91526 29995 967 25987 2817 6282 374 6189 51435 8568 5238 113146 1191 149345 10486 1737 5901 9770 3146 80305 9411 57584 1656 51335 10972 874 914 200407 23336 1522 7456 3909 1508 11078 1956 7494 10206 9950 55450 824 55920 5393 6875 85360 169841 4175 64284 3856 92797 64114 831 3609 34 282679 79716 10884 51184 10922 11273 79444 4678 7424 51706 3082 3815 2322 613 930 5879 5728 951 PMC8326758__F1 Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms 208 581 2534 26291 5444 PMC8329443__F2 Vital Roles of LINC00662 in Human Cancers 148189 998 6010 50616 9073 1386 6722 PMC8329528__F1 Branched-chain Amino Acids: Catabolism in Skeletal Muscle and Implications for Muscle and Whole-body Metabolism 3667 9776 8408 5728 5163 7249 7248 6009 153129 PMC8332857__F5 ZNF217: the cerberus who fails to guard the gateway to lethal malignancy 2078 7764 572 581 4193 2065 PMC8335161__F1 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer 79804 51352 728655 5820 84848 284080 80307 641638 493812 100750225 55384 836 572 693193 331 842 8772 100303491 637 27429 355 4170 581 90427 2021 100885775 55000 8739 472 545 22933 3622 494333 693178 PMC8336336__F6 Diet-derived transmission of MicroRNAs from host plant into honey bee Midgut 9350 50964 4040 4041 25805 2040 6259 27130 23002 324 6477 387 6500 9475 8454 25776 4089 4088 51701 PMC8341163__F3 Cas-induced nick processing and strand replacement 142 7515 9156 3978 5111 1763 2237 5423 3980 PMC8346999__F8 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases 8737 7185 637 672 4739 3984 660 197131 23304 PMC8346999__F10 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases 22861 23304 23352 54734 197131 51366 3553 PMC8347150__F2 Impact of Hypoxia over Human Viral Infections and Key Cellular Processes 2147 2597 3939 5163 4035 2170 2173 10555 2194 3417 PMC8348617__F2 Senescence-Associated Glycine max (Gm)NAC Genes: Integration of Natural and Stress-Induced Leaf Senescence 4149 8828 8829 6295 PMC8351122__F2 Fibroblast Growth Factor 19 in Hepatocellular Carcinoma 7249 1977 6774 9965 2264 2549 10818 2885 4088 4087 9093 6016 5900 4804 4914 5781 53358 7069 6464 5770 7314 9077 5921 1398 64236 25 1956 PMC8351522__F5 Biomarkers and targets of mitochondrial dynamics 260431 6472 1716 9447 10413 114548 3458 PMC8351522__F2 Biomarkers and targets of mitochondrial dynamics 115209 64423 4976 10075 581 983 324 11331 9024 55486 192111 10013 65018 29110 55626 PMC8351522__F1 Biomarkers and targets of mitochondrial dynamics 115209 55486 10013 10075 9447 581 65018 55669 9927 56947 4976 983 324 64423 56907 PMC8354203__F3 Downregulation of miR-142a Contributes to the Enhanced Anti-Apoptotic Ability of Murine Chronic Myelogenous Leukemia Cells 4280 9350 1050 1870 329 331 4602 8544 3394 57103 1021 114609 8317 57019 5884 5366 PMC8359944__F1 Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat 790 2056 7422 5163 3939 226 285 PMC8366957__F7 Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis 9817 1728 2878 847 PMC8369426__F2 Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders 65018 664 55486 4976 139341 9927 8408 192111 PMC8370908__F3 Alteration of protein expression and spliceosome pathway activity during Barrett’s carcinogenesis 4118 29894 1665 3184 23450 51340 1660 27339 7054 51593 22826 4670 22827 56259 8189 3178 10236 PMC8372480__F1 SARS-CoV-2 infection of islet B cells: Evidence and implications 8829 59272 7113 PMC8372757__F5 Differential regulation of cerebral microvascular transcription by single and repetitive hypoxic conditioning 6850 7054 3458 324 114548 942 941 613 5163 920 940 2002 2885 2475 975 1026 5728 572 930 7157 239 933 1803 27035 PMC8379419__F2 Arginine metabolism and its functions in growth, nutrient utilization, and immunonutrition of fish 384 383 153129 3630 3479 PMC8381650__F4 NFKB: At the Borders of Autoimmunity and Inflammation 7186 7188 8717 7189 613 7535 6850 4067 3932 10892 84433 8915 90268 4615 51135 717 331 3654 64127 PMC8382834__F1 Impact of severe hypoglycemia on the heat shock and related protein response 3315 3375 3312 8550 3337 7327 10963 5530 10273 1191 PMC8383754__F3 Identification of HIF-1A/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis 3725 4313 4318 2475 3553 4843 3458 3315 6696 7157 60 348 351 2309 367 54205 1385 960 836 595 847 842 PMC8384663__F1 Multifactorial pathogenesis of psoriatic disease 5653 7124 6364 5447 10318 79092 7128 3594 7297 6775 3717 149233 861 2530 8727 PMC8384902__F5 ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer 5629 429 7080 1621 1644 3642 7042 9627 7018 1999 3280 3516 3714 4904 28514 10683 54567 3955 22903 5362 51704 6925 1749 3170 7357 7534 3398 7832 56006 9139 84002 84879 85416 5810 6093 6860 54549 890 6418 891 7027 9133 7443 983 991 9232 1062 10403 3161 10926 5501 81930 PMC8385445__F1 Leigh Syndrome: A Tale of Two Genomes 4704 4694 4695 4705 4719 55967 4722 4714 4720 4724 374291 4728 4729 4723 29078 91942 79133 137682 80224 55572 6389 644096 54902 617 27089 4514 4697 6834 9997 1355 1352 51204 100131801 10128 PMC8387394__F2 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer 3861 5081 3716 1870 650 652 1950 3198 8313 2247 6774 3976 2049 6469 3280 94234 6935 4316 4322 51176 4488 4487 6662 9464 57332 3211 3037 5156 4087 1499 89780 4838 5806 27022 860 8091 3159 5077 10631 2625 54822 3480 3481 2885 3667 1956 5728 23328 5879 6010 2475 2064 7046 4088 5159 4092 9839 7048 960 4193 9898 29904 4313 4318 25805 PMC8387394__F3 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer 6608 5727 332 999 7852 1000 2736 2737 27022 535 374946 6662 6657 6663 822 102 8754 4318 4313 6497 6935 4041 4322 83737 22943 2064 11113 2535 324 9113 26524 1499 6714 2067 6387 6774 4854 23286 1655 2309 387 2002 338557 PMC8387394__F4 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer 4312 27022 79923 6662 6657 4089 4093 5118 7040 1758 4921 6678 1832 7043 468 5655 1499 3690 4313 4325 387 3688 2495 4322 8650 6868 596 375033 9531 23312 1072 10013 3397 2113 6935 9794 3159 8076 4318 6774 648 PMC8387394__F5 Conservation of epithelial-to-mesenchymal transition process in neural crest cells and metastatic cancer 355 11124 6469 1280 27022 894 6608 253782 2736 2737 2301 5080 7416 648 3091 3956 1019 6304 6286 2932 8852 3280 1395 729230 6657 2735 6774 139628 9839 PMC8388033__F4 Multi-layered network-based pathway activity inference using directed random walks: application to predicting clinical outcomes in urologic cancer 355 3992 36 35 8310 54995 1375 2182 92421 3119 5834 5836 3108 3695 7040 801 55970 5595 51764 148327 54331 4915 246 3425 10060 411 6778 2752 5837 5825 24 3034 6773 8714 64241 8881 8697 997 27339 326 PMC8388923__F7 Nepetoidin B from Salvia plebeia R. Br. Inhibits Inflammation by Modulating the NFKB and Nrf2/HO-1 Signaling Pathways in Macrophage Cells 4703 9817 7124 PMC8389681__F4 Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context 5911 1540 23512 5306 55031 3265 7157 1312 150274 26580 719 6472 8027 1491 2859 11201 4598 22872 996 230 10488 7415 79608 11236 4597 2936 7316 54187 10135 PMC8391894__F2 DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity 1763 9156 672 5888 5426 PMC8393955__F6 Implications of a ‘Third Signal’ in NK Cells 23118 10454 4615 51135 7189 3595 3717 6775 3594 7297 7124 1232 1233 1234 149233 10148 6097 6095 3716 4283 3627 PMC8395015__F1 Altered L-Arginine Metabolic Pathways in Gastric Cancer: Potential Therapeutic Targets and Biomarkers 23564 23576 4843 383 384 435 445 4953 PMC8395241__F7 Analysis of PPARG Signaling Activity in Psoriasis 353376 148022 7189 2353 3725 4214 6885 59067 4615 5604 6774 112744 6794 3605 3845 6714 6097 5468 1956 5747 5170 207 7249 PMC8396208__F2 GDF15 and Cardiac Cells: Current Concepts and New Insights 9518 650 1385 238 389400 4976 9242 26291 PMC8396448__F3 Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina 6668 6667 79792 22926 7186 468 834 842 8717 637 581 8772 836 790 572 PMC8396448__F4 Pathogenesis and Therapeutic Approaches of Diabetic Neuropathy in the Retina 6446 5728 1977 5163 7249 7248 2932 627 4929 9021 3976 3977 6774 6772 PMC8397987__F3 Fructose and Mannose in Inborn Errors of Metabolism and Cancer 2203 4351 3795 229 619501 PMC8405290__F5 Exploring the Mechanism of Action of Herbal Medicine (Gan-Mai-Da-Zao Decoction) for Poststroke Depression Based on Network Pharmacology and Molecular Docking 5328 43 1135 9429 1869 5970 1956 18 1815 891 6373 100188835 3037 351 5578 4314 1129 4319 3757 2944 572 7422 5467 5465 6696 3099 151056 7124 6720 5054 50506 581 860 1543 1576 1277 2353 1281 595 598 3486 9536 3315 3551 54658 1019 3949 31 847 890 196 4318 2194 5468 2155 2920 4313 5743 5447 5662 2002 153 2936 25825 5837 4846 4193 4353 5530 3359 3627 8644 3725 6347 2152 1017 3606 1509 331 1147 6095 840 367 1128 4953 6590 6401 4306 3481 6774 3156 596 4133 4547 11200 2950 653361 4609 3297 1544 842 5925 PMC8406474__F2 NRF2 signalling pathway: New insights and progress in the field of wound healing 1728 9978 8452 4094 9817 847 PMC8406911__F8 CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/Beta-catenin signaling via CTNNB1 5725 83939 1977 1499 51176 595 4316 960 7422 PMC8412110__F5 Cdc42 signalling in cell migration 387 55619 5062 998 6774 5879 3717 PMC8413067__F1 The Wound Healing through Noncoding RNA Interplay and GSK-3B/NFKB Signaling Interaction 285943 105416157 7124 8915 3551 6387 7852 4513 177 PMC8413680__AF1 LINC00941 promotes glycolysis in pancreatic cancer by modulating the Hippo pathway 4485 100287314 3099 5209 10413 3939 2023 PMC8414903__F2 Ferroptosis Pathway by Ubiquitination 6520 23657 2242 4891 2937 55240 2512 7037 PMC8416736__F4 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations 3479 19 7099 3553 114548 PMC8417734__F2 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases 4041 5218 55294 84133 54894 8549 324 4040 1499 4920 4919 1152 387 1386 3725 998 PMC8418449__F4 Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease 57103 2147 2597 3939 3945 132949 27040 2539 26227 7086 4199 3418 3417 387 3156 2937 6510 PMC8418613__F4 STRING pathway analysis of LM and LuM CD11b+ druggable proteomic targets 2799 4669 3965 5713 490 6774 4067 5770 8804 3959 5701 1666 4353 1991 4257 140885 1536 8993 3240 23385 10376 5836 240 87 1278 3920 4318 348 10383 102 4624 5837 246 1282 811 6184 3146 3688 10130 3913 7184 3329 7273 10549 8971 4811 6059 3911 9601 2923 3339 10061 PMC8419687__F2 IL‐4‐induced changes in metabolism and their effects on gene expression 6778 3662 948 383 1984 PMC8421919__F2 Bioinformatical identification of key genes regulated by IGF2BP2-mediated RNA N6-methyladenosine and prediction of prognosis in hepatocellular carcinoma 4176 203068 55831 3159 10417 1476 51659 8972 4485 389 890 55355 22974 9021 5595 10763 3339 147841 8836 83461 995 3148 1869 2305 113130 5159 3265 7534 55651 10036 10460 4172 3481 PMC8423996__F2 GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism 8651 9021 6868 59272 PMC8425214__F4 Regulatory networks of the Hippo signaling pathway in cancer development 60485 4485 9113 26524 6010 761 PMC8425390__F1 Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling 3265 572 596 1956 2885 7529 5894 10125 PMC8425390__F3 Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling 3265 673 7529 5894 6395 4140 PMC8427320__F3 Potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine 5728 2475 6714 3091 999 1000 581 PMC8428079__F2 Targeting Beta-cell dedifferentiation and transdifferentiation: opportunities and challenges 100187761 5156 3098 4942 4638 5970 5971 5879 7124 998 7186 3630 8717 8772 389692 PMC8428233__F2 Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors 4087 4088 4089 6957 860 3716 6772 3717 6774 581 999 79923 100133941 4609 PMC8430761__F1 Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends? 6774 25970 3717 9021 8471 2885 4852 181 23373 3643 5163 5728 2475 3814 9607 5443 PMC8432812__F5 Proteogenomic analysis of pancreatic cancer subtypes 54894 759 324 11316 7090 27122 27121 23013 6794 2033 253260 5728 208 441478 7248 7249 7006 100124696 2475 6009 10000 57521 PMC8434408__F5 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells 6741 9156 5395 4436 2956 4292 4437 27030 5111 PMC8436408__F1 Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NFKB Modulators 51311 51284 4513 PMC8438590__F1 Antibody dependent enhancement: Unavoidable problems in vaccine development 3661 7187 3665 9474 9140 29110 7098 10010 6850 4615 2932 3586 6774 3717 10379 PMC8450475__F1 Manifestations and Management of Hepatic Dysfunction in Congenital Disorders of Glycosylation 5236 4351 5373 55532 147007 84317 10159 29880 79796 79087 55858 10195 PMC8450533__F5 RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells 2331 79875 3458 7124 4838 148738 285704 25805 126669 1616 64750 57154 387 4091 4092 4087 4088 8454 6500 4089 3611 7408 1874 572 PMC8454558__F5 Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors 3082 1399 2305 2885 9212 6790 5347 1950 2549 6714 5728 2475 2621 1019 1029 PMC8458546__F3 Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement 284 8829 7026 7422 51070 4851 4846 857 1785 836 841 115677 2113 3672 4318 3685 84432 2885 2982 10161 5899 2977 196883 107 2846 5336 1145 113 5911 23551 5320 5817 PMC8458655__F9 Research Progress on the Functions and Mechanism of circRNA in Cisplatin Resistance in Tumors 79872 664614 205 693141 8087 3205 4363 6774 724024 5980 PMC8458965__F2 MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis 5094 5093 79671 29110 54941 6048 5494 5496 51701 57506 80196 220213 6737 7706 11074 11124 8473 PMC8463275__F2 Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy 1021 1019 1022 355 2475 672 983 1017 1025 6741 2232 3815 4609 51755 PMC8464970__F7 Ergosta-7,9(11),22-trien-3Beta-ol Attenuates Inflammatory Responses via Inhibiting MAPK/AP-1 Induced IL-6/JAK/STAT Pathways and Activating Nrf2/HO-1 Signaling in LPS-Stimulated Macrophage-like Cells 847 8452 9817 7099 4615 114609 8195 8737 8717 3569 PMC8465124__F1 Splice and Dice: Intronic microRNAs, Splicing and Cancer 29102 54487 51163 PMC8465210__F15 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity 3082 1398 2549 6714 PMC8465904__F2 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells 60485 4485 9113 26524 1499 2932 4318 4313 4316 960 1956 324 4092 7124 11201 1440 1435 1437 5163 5164 331 666 637 1950 999 5111 3082 182 PMC8466551__F3 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis 7291 9839 6935 6615 1000 4314 4318 999 7422 8828 2250 6662 4323 4313 596 9429 5243 581 595 894 6352 6347 4286 PMC8466551__F7 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis 3480 2735 6662 6500 8405 9968 PMC8468289__F1 Influencing Factors and Molecular Pathogenesis of Sarcopenia and Osteosarcopenia in Chronic Liver Disease 6009 5163 7249 7248 64798 4087 5728 1977 1998 4089 8408 9776 4654 4656 6446 387 10397 PMC8468661__F7 Mitochondrial Disruption by Amyloid Beta 42 Identified by Proteomics and Pathway Mapping 51393 1830 196527 8904 5569 2035 2280 10627 4627 7533 8604 10165 29957 3954 10939 50487 213 5478 7416 7417 6748 79784 93664 2195 5048 PMC8468691__F6 4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells 2475 1019 595 983 891 581 317 PMC8469440__F1 Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies 3620 169355 8564 130013 23475 PMC8469852__F3 Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders 196 9049 405 PMC8470786__F2 Interaction between microRNAs and the Wnt/Beta-Catenin Signaling Pathway in Osteoarthritis 51701 6662 1499 100187761 2296 2932 324 PMC8471358__F1 Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives 3479 3480 2475 4087 4088 4089 6774 7099 PMC8472231__F7 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells 7291 1969 2149 301 3383 29108 834 6347 6382 1535 6696 7099 2353 7097 960 3592 929 10346 2690 9180 5371 9636 4599 3433 684 6672 2633 4684 54739 4067 3119 3665 3659 4938 4939 PMC8473087__F5 COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NFKB Pathway 7113 7098 51311 51284 59272 3665 3586 3596 3565 7099 3627 7412 3383 PMC8476624__F5 Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study 183 3263 1 3043 5004 3827 116844 5265 1356 3039 5005 213 197 3240 7018 336 8455 7276 350 563 173 259 5950 1063 51279 686 114770 PMC8476624__F6 Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study 345 51279 259 338 350 3039 174 336 335 3240 3043 563 1356 1636 116844 2147 183 462 197 5004 3827 213 5972 624 5005 2158 2159 173 1 710 7276 114770 8455 5950 686 PMC8476809__F2 Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers 4976 9927 51024 65018 83939 468 581 7124 9140 9474 10533 8408 5081 4087 4088 3479 7248 7249 2475 PMC8478533__F3 Crosstalk between Heart Failure and Cognitive Impairment via hsa-miR-933/RELB/CCL21 Pathway 9575 7392 10155 7702 57506 6790 4255 7431 1508 5813 79068 1408 7030 239 488 6366 5187 1991 55872 671 31 10398 100188776 2778 998 2521 8409 10628 6648 8189 1622 8082 572 6319 790 2069 1362 6402 7077 81 7182 6770 54106 4520 360 2117 6782 929 6720 PMC8478550__F1 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases 3718 3597 7297 4087 4088 4089 1386 114548 7124 PMC8484370__F3 Distinct TLR signaling in the salamander response to tissue damage 7098 7187 29110 3661 3665 7097 4615 10333 23118 257397 3654 51135 7189 7096 7100 51284 1386 54106 PMC8484567__F6 Dramatic transcriptomic differences in Macaca mulatta and Macaca fascicularis with Plasmodium knowlesi infections 3661 4283 3606 958 57506 3665 3627 3437 9636 3669 8638 4599 11274 7099 7186 3458 3586 3551 7187 684 6773 8651 10379 151636 9447 3717 3394 9021 3383 3659 7297 2919 151176 PMC8486873__F2 ER stress regulate the secretion of EVs which contained immunomodulatory factors 3146 7099 324 5728 3586 PMC8487456__F4 Quality control and recycling of peptidyl-tRNAs on stalled ribosomes 9147 26046 847 55520 90806 4553 51095 55139 3297 PMC8489191__F1 Post-translational modification control of viral DNA sensors and innate immune signaling 9447 3661 9208 1499 115004 3428 4361 29110 3312 51428 57506 3181 54106 4615 170506 1660 PMC8489222__F4 Targeting smooth muscle cell phenotypic switching in vascular disease 4485 9113 26524 60485 6010 595 894 PMC8490516__F8 Kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis 5163 4280 7037 50943 29851 PMC8491037__F1 Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint 95 5091 4018 1605 PMC8491218__F3 Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors 5045 8324 25865 2638 8521 2920 861 3976 5340 2913 3480 581 5243 1021 3562 2308 1576 3084 10718 1244 2886 558 598 4790 3643 6615 4921 5979 2641 4602 7135 8503 116535 25769 5159 6469 4916 1026 9362 83697 781 1385 5579 1435 25759 5393 60 5078 2534 2300 5580 284323 1308 6520 2006 7373 55128 10482 7163 2064 596 208 8936 4067 6654 3164 6927 6929 3932 7431 7248 2244 7424 5168 3002 22801 10810 1969 1869 5743 6844 4318 1559 1557 28232 2785 140609 55691 6935 2867 94027 8607 3294 1586 51176 9532 5327 5971 6783 7161 3159 196 2492 2255 5064 5367 1836 27340 7043 5076 8322 659 11211 6364 4211 54414 PMC8496081__F5 Genetic and epigenetic associations of ANRIL with coronary artery disease and risk factors 6908 6872 6873 6880 6878 PMC8499523__F6 Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide 5329 1848 890 5311 56241 5447 6355 3921 8912 3627 4283 123 5563 6929 22918 4792 1958 5270 3105 6366 196 1499 2149 84417 1437 3688 1959 2624 10758 80760 3429 5025 1033 8517 3458 3620 3663 1668 8516 2200 1901 3161 120406 PMC8499812__F6 DeepDRIM: a deep neural network to reconstruct cell-type-specific gene regulatory network using single-cell RNA-seq data 378 4208 6503 8724 1973 1870 83658 7150 1854 7756 7415 3148 51065 22806 100187761 6672 103 78988 57169 5691 100 5062 2879 5725 836 11262 9404 3192 1385 7171 7018 80709 4773 257101 4149 PMC8505617__F5 The Hedgehog signaling pathway and the interactions between lncRNAs and the pathway 6608 51684 23432 5727 100124700 PMC8505885__F1 Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations 613 22800 6774 958 5163 3939 3099 2308 7187 5079 3662 2147 2539 25874 PMC8506063__F7 Bioinformatics analysis reveals the roles of cytoskeleton protein transgelin in occurrence and development of proteinuria 7097 613 6850 930 5879 2885 3667 5728 5163 11140 7248 7249 572 4193 672 4609 5934 3158 335 4199 4023 7350 3611 7316 5360 4973 4312 364 1977 PMC8507033__F2 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining 10533 5728 2475 2308 60674 581 1938 57616 3236 PMC8507163__F5 Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis 4999 27436 238 6500 6502 4609 4171 10278 619410 5291 5293 208 10000 572 7150 581 51426 472 545 30062 1956 5578 5579 3064 3265 3845 369 673 5894 5295 5290 5447 8503 64065 5728 2033 5925 1869 1870 1871 64326 1029 7272 699 7529 7531 54205 1382 5915 6095 6257 6258 835 2272 637 266710 836 10393 996 PMC8508046__F3 Targeted Sequencing Revealed Distinct Mutational Profiles of Ocular and Extraocular Sebaceous Carcinomas 4297 6601 6597 6598 6233 2033 5925 2956 7157 55294 4763 472 6500 54894 5290 673 5295 8503 5296 1387 4436 9794 4193 4194 PMC8508942__F2 Vascular Smooth Muscle Cell Phenotype Switching in Arteriogenesis 4088 4087 57591 57496 93649 6722 6010 2002 1950 9314 PMC8509327__SF1 Non-Canonical Wnt Signalling Pathways in Bone Biology 4040 4041 324 1499 607 4920 PMC8509779__F1 Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways 59272 7124 6774 3383 7412 324 941 940 7054 PMC8511224__F2 WNT4 signaling pathway 324 1499 4920 85451 3725 23500 23002 387 1386 PMC8514763__F3 Non-Coding RNAs Inducing Drug Resistance in Ovarian Cancer: A New Perspective for Understanding Drug Resistance 693215 7124 578 6774 406988 5728 3717 80036 1499 5163 6422 51701 4485 9113 26524 23152 2118 PMC8520942__F1 Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 Mutations 7465 983 1017 4553 2879 3301 9961 PMC8523993__F8 Performance Assessment of the Network Reconstruction Approaches on Various Interactomes 5295 5290 5291 5296 5293 472 5170 7157 2033 675 672 4303 2309 2308 2956 2549 6714 7248 7249 5294 1021 1019 5925 5159 1956 2263 2064 3480 2065 1869 1017 898 2885 867 5608 4893 3265 5609 5604 3845 6416 5607 5605 5286 5287 10253 5595 5594 4018 5578 5583 5584 5582 5588 5579 5590 5580 4763 350 10516 351 4321 PMC8525106__F4 Key radioresistance regulation models and marker genes identified by integrated transcriptome analysis in nasopharyngeal carcinoma 3725 835 5111 7157 57504 7532 10193 10383 1111 1386 6500 472 993 672 673 5903 7045 4303 1017 917 1647 9491 7067 1981 5291 7529 PMC8526348__F2 Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction 3075 114548 3606 7018 7450 7099 3383 7412 718 6714 6010 PMC8527296__F1 Putative type I interferonopathy genotypes 79621 10535 84153 5422 25939 1777 641 472 5718 5692 5684 5696 56984 5698 5699 51371 714 712 713 11277 115004 219285 8651 5167 51816 134353 4938 8635 1314 3454 55210 3716 6772 3455 87178 55768 11274 9636 6773 PMC8530779__F7 Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing 1636 57506 7098 4615 51284 3553 7187 3665 3661 7124 PMC8532910__F1 Preclinical Evidence for the Interplay between Oxidative Stress and RIP1-Dependent Cell Death in Neurodegeneration: State of the Art and Possible Therapeutic Implications 8717 1540 8772 7124 355 197259 PMC8533075__F10 Salvianolic Acid C Protects against Cisplatin-Induced Acute Kidney Injury through Attenuation of Inflammation, Oxidative Stress and Apoptotic Effects and Activation of the CaMKK–AMPK–Sirt1-Associated Signaling Pathway in Mouse Models 2878 85451 7099 23411 581 PMC8533696__F3 Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives 596 4170 3280 54567 999 23462 6774 8650 PMC8533760__F1 ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer 1848 1849 3799 1844 1843 1847 1852 23022 3831 6667 2002 6772 PMC8533944__F2 Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance 9113 374 2353 256297 4609 1956 2885 PMC8534037__F2 Microenvironmental Reactive Oxygen Species in Colorectal Cancer: Involved Processes and Therapeutic Opportunities 4089 4087 4088 3082 2932 999 1499 PMC8535226__F2 Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could Distinguish between Ulcerative Colitis and Crohn’s Disease 7057 10468 3458 4052 25805 4838 7046 4090 4086 4091 4092 64750 57154 4087 4088 387 1616 4089 9978 8454 6500 6093 1874 6667 5308 PMC8535311__F2 Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis 1499 2932 324 595 6935 999 PMC8535591__F2 Insulin-like Growth Factor 1 Signaling in Mammalian Hearing 1843 3479 2885 3480 595 5163 2932 2305 993 7249 7248 6009 1017 572 8408 9776 60673 PMC8536186__F6 Fractionated Seminal Plasma of Boar Ejaculates Analyzed by LC–MS/MS: Its Effects on Post-Thaw Semen Quality 7808 2774 472 6118 213 6767 4208 1398 9261 57122 8086 8021 6396 1762 5226 1475 351 972 1785 10484 PMC8538427__F11 Polar Oxy-metabolome Reveals the 4-Hydroxymandelate CoQ10 Synthesis Pathway 51805 84842 3242 10229 728294 197257 84274 2184 51004 27235 PMC8539333__F1 Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence 5728 4942 196 1544 1543 1576 1017 1019 595 898 2876 1786 6774 10131 581 114548 PMC8541835__F1 RNases H1 and H2: guardians of the stability of the nuclear genome when supply of dNTPs is limiting for DNA synthesis 7150 4549 6052 PMC8544255__F2 Deregulation of the canonical PI3K signalling pathway during CRC treatment 3845 1956 1977 6194 54433 9846 5728 5163 4193 100616133 572 3716 PMC8544255__F3 Deregulation of the canonical Wnt/Beta-catenin signalling pathway during CRC treatment 324 4040 4041 23326 607 1499 643911 596 PMC8544255__F4 Deregulation of the canonical Notch signalling pathway during CRC treatment 9429 596 3280 896 PMC8545927__F2 Elucidate multidimensionality of type 1 diabetes mellitus heterogeneity by multifaceted information 345611 9580 1636 1511 55907 5799 3122 4012 5669 3120 186 5972 2774 4052 2776 5981 9748 2934 26191 2022 5829 57818 660 4137 5782 3569 1674 8471 685 835 3630 117289 1363 8428 5702 2169 50943 326 5715 2646 5798 3458 3710 5640 100507436 3135 PMC8548344__F1 Paracrine Hh signalling in the mammalian intestine 64399 6608 51684 2736 2932 27148 2619 2735 PMC8551152__F6 Schematic diagram 3417 3091 7040 1874 4088 960 1116 602 7076 131540 PMC8551477__F5 Insulin action at a molecular level – 100 years of progress 5266 5163 150677 3643 2308 8660 200186 3651 3170 3630 2645 6928 PMC8552790__F9 Schematic diagram of GTF2F2 related functions 4149 581 4609 596 1025 983 PMC8553038__F2 Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases 977 928 967 975 7105 7103 7852 2597 7251 1499 7474 54361 7481 6774 4313 4318 407006 23411 5728 4087 PMC8554507__F1 Modular map of Bradykinin-mediated inflammatory signaling network 1674 3265 5922 126014 1147 5970 7422 5478 5747 54331 2782 2776 2778 4137 2767 23209 5290 2475 22802 5829 5742 831 581 PMC8555654__F6 Semaphorin3F Drives Dendritic Spine Pruning through Rho-GTPase Signaling 7074 5879 4897 5063 5062 5058 3984 3985 6405 387 6093 9475 PMC8557192__F1 New biological triangle in cancer: intestinal microbiota, immune checkpoint inhibitors and antibiotics 1020 940 3716 3717 7535 3932 5728 325 942 941 PMC8560708__F1 Targeting DNA Damage Response Pathway in Ovarian Clear Cell Carcinoma 7508 5111 545 472 5888 3981 7518 PMC8560752__F7 There might exist a constrained workflow model among ERA, ARSD, and Hippo/YAP pathway 4485 60485 9113 7003 8463 7004 7005 414 PMC8560953__F7 Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells 56852 353497 51455 5111 PMC8569372__F6 Alternative splicing in human cancer progression 641638 404266 3178 4751 5725 101805488 6510 PMC8570279__F1 Transcriptional Control of Metastasis by Integrated Stress Response Signaling 9817 83939 90993 468 100126333 467 378938 PMC8570289__F1 Key Activating and Inhibitory Ligands Involved in the Mobilization of Natural Killer Cells for Cancer Immunotherapies 2885 2475 3133 962 7535 3107 3105 3106 3932 201633 6850 7409 2534 PMC8570409__F5 Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn 114548 59341 115004 59272 6868 1636 PMC8572421__F3 Contradictory roles of lipid metabolism in immune response within the tumor microenvironment 6774 948 2194 383 50943 4481 7046 3579 2475 5465 PMC8572460__F1 Ferroptosis in lung cancer 3934 57558 4057 7037 8031 30061 7018 3658 48 3309 5447 468 4780 55611 6520 23657 2729 2937 875 2879 2936 7157 467 494331 100302228 8678 84883 1723 100 2182 10162 PMC8572597__F7 Exploring the Effect of Jiawei Buguzhi Pills on TGF-Beta-Smad Pathway in Postmenopausal Osteoporosis Based on Integrated Pharmacological Strategy 2331 10468 7124 79875 4838 25805 64750 57154 6010 4087 4088 8454 4089 PMC8573099__F6 Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule 23193 55209 2548 8972 1103 3613 2717 5338 29124 43 2595 55586 3101 130589 6476 3938 2645 60496 1119 3099 1120 443 1178 51380 2572 1359 790 11001 57094 150465 175 440 10965 3032 7173 4353 57176 570 4025 10993 587 3033 10449 5091 1962 10667 126669 2193 8288 197257 5053 2875 10056 84706 1738 1491 7054 10994 1644 189 1610 4357 3945 3948 10873 5313 3939 1737 PMC8574228__F2 Fibrotic–inflammatory remodelling in heart failure with preserved ejection fraction 7412 6774 4087 4088 4089 7220 7225 7222 1281 1277 4322 4312 4317 4318 4313 4314 4015 6761 6678 PMC8577020__F1 P53 family member p73 in the regulation of cell stress response 581 545 472 1869 10413 1327 1647 5888 675 891 PMC8579187__F4 Interactions between the renin–angiotensin, complement and kallikrein–kinin systems on the vascular wall 5648 10747 716 59272 1636 730 729 735 PMC8579641__F2 Regulatory mechanism of neutrophil extracellular traps in cancer biological behavior 6774 2972 3146 54106 7099 4318 PMC8580341__F3 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors 102724122 126669 2885 5728 643911 55384 100885775 3217 4883 255082 4193 100885779 PMC8580341__F4 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors 8195 5894 6774 7297 993 3717 5292 9314 596 PMC8580341__F6 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors 572 5728 6657 5163 4193 581 7248 7249 6009 PMC8580782__F0 Erythrocytosis: genes and pathways involved in disease development 2056 7428 54583 1387 405 10168 3939 4318 5230 PMC8584061__F4 Emerging Importance of Tyrosine Kinase Inhibitors against Cancer: Quo Vadis to Cure? 1956 2260 5979 867 5781 5879 2064 2263 6098 54206 2065 3717 2261 238 3845 5594 5728 2066 2264 2322 6654 3265 369 5604 5921 5290 3815 4914 4763 673 5295 5156 3480 4915 6016 PMC8589435__F4 Crosstalk between canonical and non-canonical Wnt, Hippo and Notch signalling pathways 89780 8324 4040 6010 8549 8313 4485 10413 9113 652 22943 3280 474 PMC8590100__F3 Innate immune remodeling by short‐term intensive fasting 5894 9706 9776 9140 10533 60673 83734 7249 64422 2597 207 208 6009 55014 572 3916 2475 64798 64223 3146 9474 9342 29110 10010 81671 55255 1509 1514 1508 7189 7405 9711 PMC8591115__F2 KRAS mutation: from undruggable to druggable in cancer 5900 998 29110 7074 3845 1950 2475 572 PMC8592284__F4 Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application 47 2744 4482 2309 2033 468 5599 406982 406900 8140 PMC8595937__F1 Bruton’s Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures 6387 7852 847 1398 5829 1445 2534 4690 9564 64857 3702 998 5062 71 6010 5879 5058 1073 7535 7409 6093 3718 3717 7094 5337 5906 7414 83593 695 3383 PMC8602059__F1 Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma 8717 7186 7188 56957 79155 1540 255082 105416157 4615 7189 23118 257397 10454 100506930 7415 283131 100507246 171423 4055 7187 5971 574461 PMC8602339__F1 Searching for DNA Damage: Insights From Single Molecule Analysis 7507 2067 7508 5887 27343 11201 PMC8602690__F2 Mechanism Actions of Astragaloside IV Prevents the Progression of Hypertensive Heart Disease Based on Network Pharmacology and Experimental Pharmacology 7124 5970 6648 7422 4353 1147 PMC8608616__F4 Redox regulation of DUBs and its therapeutic implications in cancer 1540 3553 8237 8975 7398 5728 23239 10869 57646 7039 3481 7249 6774 PMC8610166__F2 Targeting myeloid-derived suppressor cells for cancer therapy 10507 383 3579 6347 729230 3067 PMC8611092__F2 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression 5163 2475 572 6247 5728 613 PMC8611496__F9 Noni on cellular viability and osteogenic differentiation of gingiva-derived stem cells demonstrated by RNA sequencing and quantitative PCR 7057 2331 10468 650 652 79875 3458 7124 4838 4756 25805 7046 387 1616 4087 4088 9978 8454 6500 4089 1874 5308 PMC8612621__F3 Crosstalk Between Parkinson's Disease and Energy Metabolism 7351 22944 596 581 PMC8614257__F8 Equine Endometrosis Pathological Features: Are They Dependent on NFKB Signaling Pathway? 3550 5970 8205 3569 3037 PMC8614808__F4 TRAP1 in Oxidative Stress and Neurodegeneration 6774 10131 1869 1000 83939 1998 468 PMC8615614__F1 Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma 5728 4193 7249 7248 6009 2931 2932 PMC8615627__F1 LncRNAs: Novel Biomarkers for Pancreatic Cancer 7503 6010 7018 7189 100129597 4089 4838 4092 4087 4088 4090 4086 860 3984 100287879 PMC8615762__F1 Chemokine Pathways in Cutaneous Melanoma: Their Modulation by Cancer and Exploitation by the Clinician 8205 3579 3577 729230 1235 2920 2919 2921 3576 6372 6374 6351 6352 6348 6347 6364 6367 6361 1233 1237 6346 4283 3627 2833 2826 10850 1236 3082 1950 6366 1234 7852 10803 6387 6370 PMC8616071__F1 Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors 5209 4199 2067 472 983 896 1021 1019 672 5888 100187761 6241 PMC8616147__F6 RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERA)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2 2305 4485 10413 PMC8616288__F2 FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance 7248 2932 597 595 596 6774 7297 PMC8616477__F2 Melanoma Targeted Therapies beyond BRAF-Mutant Melanoma: Potential Druggable Mutations and Novel Treatment Approaches 4193 1019 369 673 2475 572 2146 581 596 3418 54790 PMC8617565__F4 Proteome Analysis of the Hypothalamic Arcuate Nucleus in Chronic High-Fat Diet-Induced Obesity 4803 1398 10818 627 1432 2885 53358 2549 572 2932 PMC8618802__F7 Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy 8772 2475 637 4170 472 545 581 331 55332 317 PMC8620049__F1 Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers 3815 4893 581 PMC8620858__F1 Hypoxia: The Cornerstone of Glioblastoma 3939 5163 5728 2475 664 2056 6923 6921 7428 8453 9978 26043 4851 6657 PMC8623546__F10 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease 4485 60485 27040 7462 7018 6010 PMC8623825__F1 Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections 9817 6647 6648 847 PMC8624829__F4 Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway 1991 5335 5290 1909 4638 154 775 10398 5595 1432 5468 4843 1080 1129 776 6651 6714 5966 5578 5579 773 816 5566 43 5747 5294 5580 PMC8625880__F2 Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair 9156 5888 675 79728 672 5893 142 5426 3978 3980 286257 PMC8625880__F3 Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair 1642 1643 7508 1069 2067 5111 7507 57654 7874 PMC8626127__F8 Ovalbumin antigen-specific activation of human T cell receptor closely resembles soluble antibody stimulation as revealed by BOOST phosphotyrosine proteomics 940 5788 7535 3932 917 916 6300 915 2885 3702 27040 5335 4690 2353 PMC8628126__F2 SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases 6772 1385 4135 5606 4134 466 7936 3558 3569 3315 387 998 6010 6093 9475 5058 3925 5062 7431 1460 1495 3066 3159 3150 PMC8628461__F5 Comprehensive analysis of miRNA–mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse 836 637 3106 3107 3384 4277 100507436 962 355 4118 6850 27040 2885 8213 759 373073 8480 7124 PMC8630816__F3 MCP-1 targeting: Shutting off an engine for tumor development 8205 90865 7124 2932 6774 2475 9966 6714 PMC8632547__F5 Hippo Signaling Pathway: The Trader of Tumor Microenvironment 9113 26524 4920 4919 6010 324 1499 PMC8635032__F1 Recent Progress of Ferroptosis in Lung Diseases 8314 2879 6774 1728 2495 6303 2182 10162 PMC8636012__F1 Importance of Cellular Metabolic Pathways in Pathogenesis and Selective Treatments of Hematological Malignancies 3099 2744 2539 3418 2194 PMC8636732__F2 Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors 999 1499 2932 324 4087 4088 4089 1956 5058 10400 6935 9839 3082 3091 1000 PMC8638098__F6 Gene regulatory networks analysis of muscle-invasive bladder cancer subtypes using differential graphical model 6754 2743 5734 2358 2846 718 2555 887 255061 3062 1081 200959 4159 7068 1132 3001 2914 1816 6750 9248 5179 6751 133 1909 27334 154 51052 1142 2742 6343 22953 339403 3356 2692 55879 5029 57105 135 2359 90226 1908 799 1146 51738 1813 7432 886 1906 7201 4160 1269 1145 3640 57053 5024 2859 9002 6870 6755 5367 5618 2906 2893 2566 151 5026 283869 183 1241 2150 165829 4829 3358 5739 1143 2696 5025 6344 9340 8001 2563 8862 1131 117579 114131 2641 9568 2642 2645 3357 2908 2690 6915 6866 6019 2895 3952 2834 2891 3362 1135 8973 1136 PMC8638120__F3 Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases 53407 4905 23545 535 8775 2054 9550 1213 1785 773 161 1211 1212 26052 1759 PMC8639021__F3 Neurobiology of COVID-19: how can the virus affect the brain? 7113 59272 3661 51284 7098 51135 7189 10379 7099 4615 114609 PMC8640960__F3 Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension 3458 8651 29126 3002 5698 10581 6403 3569 6774 4495 4496 4504 340024 6568 246213 6584 29986 55532 60482 4319 1441 7130 3553 3845 8744 1293 7424 1440 7070 4283 3627 90865 5008 4017 3552 7045 4493 4060 51330 326343 55503 113235 1811 57282 55117 283375 85413 169026 6583 159963 6512 6347 7474 9227 79799 54658 54579 2938 124 1576 3203 3669 3283 3293 3225 91464 5271 8942 6890 3201 3235 3238 3223 9021 5169 51561 4821 27294 64711 4128 389396 1580 6817 7365 1593 6822 6799 344191 5308 3237 3236 PMC8641993__F1 Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation 4512 5226 5228 PMC8645963__F1 Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer 65220 2539 3417 3418 10873 4199 4200 PMC8645963__F2 Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer 2597 65220 2539 3417 3418 10873 4199 4200 PMC8649443__F6 Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension 383 5832 2744 PMC8649520__F1 Bioinformatic analysis of transcriptome data sets for aortae obtained from aged ApoE −/− mice fed a high‐fat diet revealed 50 overlapping genes that are enriched for ER stress‐ and UPR‐related pathways 3309 55161 5295 5771 9217 5610 581 666 348 4280 7494 PMC8652015__F2 Molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy 154 3939 4513 6347 729230 5728 5617 4609 6774 57646 2475 79923 7054 PMC8652134__F3 Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease 5105 4851 7038 9588 182 PMC8656491__F1 Impact of DNA Damage Response—Targeted Therapies on the Immune Response to Tumours 6741 142 10038 7465 472 PMC8656934__F3 Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy 3099 3939 355 383 948 PMC8657754__F7 Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy 10038 472 7057 841 637 836 581 842 PMC8658031__F4 Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19 59272 114548 6868 7187 1636 3606 PMC8658611__F5 Impact of Cigarette Smoking on the Expression of Oxidative Stress-Related Genes in Cumulus Cells Retrieved from Healthy Women Undergoing IVF 9097 7314 10574 10961 2729 873 9817 2932 5629 2512 2495 847 2877 2936 PMC8660617__F12 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 324 2099 1019 5901 9817 545 472 619501 2100 1021 8202 1874 10498 993 6502 PMC8660704__F7 DCZ0014, a novel compound in the therapy of diffuse large B-cell lymphoma via the B cell receptor signaling pathway 930 2475 613 6850 4067 6774 993 1021 1019 595 PMC8669293__F6 Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus 5009 6822 1356 6667 8202 7707 PMC8670134__F2 gcMECM: graph clustering of mutual exclusivity of cancer mutations 675 144455 699 2175 868 1956 2263 673 23513 672 9770 8844 3845 2064 5781 53358 6654 5156 5159 2264 6476 5894 4118 5327 841 50964 8139 5970 PMC8671582__F2 Pathway network analysis of the significantly differentially expressed lncRNAs and mRNAs 2475 51719 2319 5209 6583 56034 7124 5226 5836 6391 5608 26873 249 79623 1432 58484 4671 84674 2153 79621 27250 PMC8672524__F7 Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction 80152 1058 891 3619 11130 55055 9735 PMC8672651__F1 Complement as driver of and therapeutic target in COVID-19 5648 10747 2271 716 715 59272 5970 4179 PMC8678479__F2 Pyroptosis: A New Insight Into Eye Disease Therapy 114548 23118 257397 339855 4615 PMC8685420__F8 Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer 5268 387 6010 5054 4035 5340 PMC8687399__F7 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy 100506742 842 836 317 22926 581 7186 596 PMC8688647__F2 Network map of Elabela signaling pathway in physiological and pathological conditions 4879 4878 4625 1636 7042 4053 10631 2305 5594 5595 836 581 596 187 5290 207 2475 7827 11346 23410 6347 3383 1277 1490 7124 1385 5972 3934 26762 59272 7040 2335 5054 7076 3606 3558 3569 3605 3458 466 PMC8688647__F6 Network map of Elabela signaling pathway in physiological and pathological conditions 5595 4318 7431 187 5290 207 1281 581 836 1277 54205 596 4846 4313 2309 7124 6347 23410 6648 4280 PMC8698499__F12 Novel Insights into the Prognosis and Immunological Value of the SLC35A (Solute Carrier 35A) Family Genes in Human Breast Cancer 324 545 472 7494 11186 991 9184 8567 5347 6502 8556 25859 993 990 PMC8698607__F6 Comparative Proteomic Analysis of tPVAT during Ang II Infusion 7350 2475 6774 PMC8698620__F8 Murine Neonatal Oxidant Lung Injury: NRF2-Dependent Predisposition to Adulthood Respiratory Viral Infection and Protection by Maternal Antioxidant 22924 669 150946 1959 2892 10205 4752 27 2315 81610 6750 23052 80274 2810 3726 8521 10636 23764 4097 57679 27113 7808 6237 3638 6236 1431 7454 4050 3592 958 6948 5925 157313 130502 58504 729440 1820 2300 23515 10147 9242 64837 57822 7124 64151 5691 442213 6369 64405 11215 55605 8496 6793 3934 83605 3002 92610 4598 128209 51540 57050 4683 53828 4118 8731 283078 4599 123169 PMC8699626__F2 Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective 5347 9113 84962 4485 983 60485 1017 4771 1021 1019 4172 4174 4173 4176 4175 4171 26524 PMC8699889__F11 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 324 545 472 2099 2100 3565 11186 983 991 9184 5347 6502 25859 1017 PMC8702962__F4 Osteosarcoma and Metastasis 2932 3479 7852 860 6678 2247 1002 51741 2260 PMC8704013__F2 Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression 367 384 6347 729230 2475 4942 3565 7124 1950 PMC8704271__F1 Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model 7168 6387 7318 5055 23223 5729 130271 22915 8844 84623 10964 2674 2621 55619 11004 3834 2661 1871 91392 55351 6446 6328 114821 8549 58494 54360 63967 26586 834 55859 545 125 3861 367 5132 2475 PMC8705144__F1 Hippo Pathway in Regulating Drug Resistance of Glioblastoma 4771 60485 4485 9113 26524 4827 PMC8705144__F3 Hippo Pathway in Regulating Drug Resistance of Glioblastoma 60485 4485 9113 26524 4827 4771 5546 PMC8705244__F2 Alterations in Kynurenine and NAD+ Salvage Pathways during the Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3 and NNMT as Potential Drug Targets 2859 8843 4128 4129 83666 1644 952 11185 54625 55191 125061 196 23408 84875 25976 10039 419 79668 54956 883 51166 56267 2806 121278 7166 8564 64802 23057 349565 10135 3620 8942 130013 23475 93100 54981 27231 4837 285242 170572 3355 3360 15 23498 438 23428 8140 4553 PMC8708027__F3 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review 4193 5163 572 581 7248 7249 2475 PMC8708225__F1 Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia 4485 6657 9113 26524 PMC8708448__F3 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective 4485 60485 10413 2735 5727 595 898 9113 26524 648 PMC8709313__F1 TKI Era in Chronic Leukemias 613 25 3717 2885 4193 3725 5894 PMC8709963__F9 Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway 5162 5230 5238 5164 3488 5211 56729 5166 5631 5255 7038 PMC8710575__F1 Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer 999 5053 6774 1499 7045 PMC8710701__F8 Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of Systemic Juvenile Idiopathic Arthritis 1050 6774 9021 1017 6772 3716 1051 3717 5292 4318 PMC8712645__F1 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy 7518 57506 3661 3428 29110 672 115004 64170 10111 4361 PMC8713748__F2 Systems biology analysis of human genomes points to key pathways conferring spina bifida risk 115004 9021 7297 3716 3717 6093 1998 6772 6773 10379 6010 5371 684 PMC8714130__F9 Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation 4353 3553 7124 4088 999 PMC8715940__F7 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes 4311 22943 7471 7124 3630 2535 4040 177 7132 3643 6868 2904 23621 1131 55851 5663 23385 51107 83464 801 823 5530 54205 572 5595 1855 6263 3708 2932 8851 5664 9451 5610 1147 5599 3667 5293 5290 4842 468 1965 1457 10023 8312 1454 840 836 3265 5594 5604 369 2475 7186 324 842 4790 1499 1452 4843 5743 PMC8718269__F4 Functions of PARP5a/b, PARP7, and PARP9 in viral infection 6772 151636 83666 142 29110 3661 56915 10000 3665 PMC8721007__F2 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy 3099 3098 3939 2744 948 3030 1374 34 95 PMC8721007__F3 Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy 8205 5163 5230 2645 3099 2023 2752 948 95 PMC8721139__F1 Potential of Ferroptosis-Targeting Therapies for Alzheimer’s Disease: From Mechanism to Transcriptomic Analysis 7018 55240 8031 6520 23657 4015 4780 2879 5212 PMC8727820__F3 Interaction between gut microbiome and anti-tumor drug therapy 1499 3855 3654 595 4615 6774 6009 2475 581 596 4049 PMC8727908__F5 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling 6597 23476 4318 9945 5970 1025 27343 11201 PMC8727908__F6 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling 23476 5970 29079 8289 4318 PMC8728107__F2 Neural regulations of the tumor microenvironment 6714 10267 10203 PMC8728107__F1 Neural regulations of the tumor microenvironment 2623 6714 6774 PMC8732267__F1 Signaling pathways regulated by GA12/13 in solid tumors 2932 9113 26524 6010 4018 998 6774 3716 PMC8739918__F4 Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis 727 1632 7099 5054 3929 3627 3458 25979 219743 100187907 PMC8741374__F4 Huanglian Jiedu Decoction Exerts Antipyretic Effect by Inhibiting MAPK Signaling Pathway 1565 1576 4314 4312 5733 5327 5742 6401 4353 7056 1956 581 5444 1401 1432 3627 7157 596 5970 959 2353 6347 1950 4609 4843 5925 3600 PMC8742403__F9 ROS/PI3K/Akt and Wnt/Beta-catenin signalings activate HIF-1Alpha-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer 1499 3099 2023 5163 3939 PMC8744613__F6 Energy Sensor AMPKA1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory 3091 2308 8320 8408 10533 PMC8745051__F2 ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors 581 3014 1017 10111 993 4361 672 995 983 PMC8745058__F4 High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling 2919 6364 383 4318 3725 5743 3627 4684 4609 2305 699 9133 1033 4084 7153 PMC8745127__F2 Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment 4485 64423 9927 65018 2886 581 51024 55669 4976 PMC8745344__F8a Multi-Omics Approach Profiling Metabolic Remodeling in Early Systolic Dysfunction and in Overt Systolic Heart Failure 7416 376497 2170 95 1375 1376 23410 51083 111 9590 11214 113026 3954 8165 845 5350 6262 811 PMC8745604__F3 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises 26524 9113 8473 8322 57608 6010 PMC8748174__F1 Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases 596 5111 1017 1019 581 999 3383 7412 PMC8750246__F1 AGEs-Induced and Endoplasmic Reticulum Stress/Inflammation-Mediated Regulation of GLUT4 Expression and Atherogenesis in Diabetes Mellitus 7494 22926 4205 177 1050 7186 1649 PMC8750386__F8 Peroxiredoxin 6 Applied after Exposure Attenuates Damaging Effects of X-ray Radiation in 3T3 Mouse Fibroblasts 9588 1017 6741 5925 472 7099 4615 7189 PMC8752857__F4 P38 MAPK pathway in Bactrocera dorsalis 658 1386 4217 6885 5606 4293 PMC8753885__F3 Identification of cardiomyopathy-related core genes through human metabolic networks and expression data 4860 318 159 122622 2766 51292 1311 4975 5313 50484 6241 6240 4832 4830 10201 29922 4831 26289 2987 3416 7054 2717 351 PMC8754411__F8 Schematic drawing showing that MSC-exo eye drops alleviate GVHD-associated dry eye disease by reprogramming M1 macrophages to M2 via miR-204–mediated targeting of IL-6R/Stat3 pathway 967 928 975 6774 383 PMC8759917__F9 Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARA Signaling Pathway 6555 1581 54898 3304 1962 7374 641371 10965 343 PMC8761570__F2 Poly (I:C) induces an immune response by macrophages 4973 2734 3988 4843 5315 PMC8763889__F2 Carcinogenic mechanism of TFF3 100169750 158038 7033 581 596 7015 572 1956 6774 3579 369 2932 2475 7852 1000 999 4512 5241 6010 PMC8764205__F8 Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts 25942 4772 1499 4920 4919 81029 1857 1856 5879 998 9475 1020 7018 PMC8767067__F4 Aberrant Expression of miR-1301 in Human Cancer 6009 1017 4638 171022 6774 1983 999 1000 9474 2932 100652772 607 8313 79923 6657 960 7422 1499 4313 9314 6422 5420 861 2146 10277 581 5111 PMC8771101__F1 Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage 942 7099 383 9332 338773 9592 735 472 6696 4023 1960 1471 3627 3433 PMC8772744__F1 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease 4615 3654 51135 637 581 8772 8717 7186 8737 717 PMC8775450__F2 Sirtuins Modulation: A Promising Strategy for HIV-Associated Neurocognitive Impairments 23411 22933 2309 4899 100 7019 65018 468 23410 4968 PMC8776968__F4 P21-activated kinases in neural cytoskeletal remodeling and related neurological disorders 998 28964 2823 5879 1000 6608 23191 11151 7074 207 847 5163 PMC8779519__F2 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis 6363 6348 6355 6368 6357 10803 1236 729230 1232 1235 58191 284340 3579 2833 7852 10663 85480 1437 3596 2056 7173 3952 2057 4352 3953 3569 3589 246778 1270 5008 3586 149233 9466 9180 1271 53832 3588 56832 3460 6761 84818 55540 132014 920 7124 4049 4050 1896 355 10913 4804 939 958 84957 PMC8779729__F1 Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential 2879 6303 10162 2182 246 9817 3315 3658 10533 9474 8031 PMC8781199__F2 Abnormal mTOR Activity in Pediatric Autoimmune Neuropsychiatric and MIA-Associated Autism Spectrum Disorders 6426 3945 10963 26986 2932 3939 1400 3091 10574 3308 22948 7157 10575 908 6950 7203 10576 3320 7248 10694 PMC8781713__F6 LRG1: an emerging player in disease pathogenesis 116844 4090 4086 4089 2022 4087 4088 6093 7018 861 1956 1950 3717 6774 1499 PMC8783446__F10 Novel Gamma-sarcoglycan interactors in murine muscle membranes 23585 113246 757 64097 137868 10579 2100 6051 7706 7402 1756 10606 23371 4666 6444 8910 6693 4691 1605 63874 5500 6445 2318 7157 6840 2064 353324 2060 5813 4137 10935 673 PMC8784222__F2 COVID-19-diabetes mellitus molecular tetrahedron 1636 4117 59272 5163 2475 948 95 4018 7097 7099 3569 1803 2695 PMC8784222__F3 COVID-19-diabetes mellitus molecular tetrahedron 8660 59272 1636 7351 7350 PMC8784548__F1 Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/Beta-Catenin Signaling 4040 55366 284654 324 1499 2274 4041 4094 150094 4313 1401 2932 1080 9732 4316 PMC8785230__F1 ERRG, a new player in the type I IFN arena 7018 3665 3661 3454 3455 PMC8786804__F5 Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer’s Disease Across Two Brain Regions 3202 3212 4846 3312 7266 6010 9378 3297 6696 3685 3694 3688 PMC8789654__F4 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway 3169 6667 2078 5800 114548 8205 619501 331 836 1544 1576 9021 1312 2475 834 847 2934 PMC8796122__F2 Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification 6714 4627 324 1499 5970 5966 2885 PMC8798411__F5 Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma 56106 56140 56142 79019 57717 56113 65125 56123 5903 613 25937 10011 10762 2114 3875 400713 57615 90827 23019 26986 5042 100506742 840 199777 51351 197320 9846 PMC8799426__F3 Trend of CRISPR-Based Technologies in COVID-19 Disease: Beyond Genome Editing 100187761 59272 4280 PMC8799702__F5 Protein tyrosine phosphatases in skeletal development and diseases 10818 2885 5728 650 659 4086 4087 4088 4090 860 6774 1499 2932 5741 4256 PMC8801426__F2 G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases 156 6772 3455 3659 551 PMC8804062__F1 Neurobiological Opportunities in Diabetic Polyneuropathy 1021 1019 5925 10371 5728 2475 387 572 581 PMC8804219__F1 Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products 6772 3156 3652 7040 4087 4088 4089 10162 2182 7417 7419 2936 6303 999 23657 6520 2937 2879 9817 1728 2495 8031 2512 55240 26234 3658 48 6510 27165 PMC8804219__F2 Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products 4094 6117 30061 23657 54914 27165 6303 2182 7037 2729 2012 51129 2495 2937 PMC8805398__F1 Rapamycin, Acarbose and 17Alpha-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation 3569 4280 7124 1977 PMC8807567__F2 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance 9978 9817 8452 406 2877 7296 2632 2539 3553 PMC8814392__F2 Restoration of miR-223-3p expression in aged mouse uteri with Samul-tang administration 1521 9476 8120 2769 5737 1509 1075 914 924 4311 246 2526 2921 3373 2946 8854 8789 283208 622 56603 9945 64768 5277 26227 84002 9388 8877 10993 3290 9060 3034 144193 3067 100 PMC8814461__F2 Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer 8091 6774 648 57804 672 5295 5728 2475 6662 79923 6657 581 5163 3068 596 11278 6935 1499 999 2305 PMC8814915__F1 A9-Containing Nicotinic Receptors in Cancer 55584 331 9647 581 7291 3958 6774 PMC8815087__F4 Phosphodiesterase 1 (PDE1) regulated cAMP and cGMP signaling pathway in cancer and neurological disorders 5153 627 342538 1267 29128 PMC8822596__F3 Ferroptosis in cancer and cancer immunotherapy 8678 23657 2879 2937 27198 6647 2182 50507 9817 5728 10162 4771 7037 PMC8827382__F1 p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets 7124 8772 4193 596 581 2475 PMC8830536__F2 Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease 1499 4018 729230 3383 650 5209 860 7097 7099 PMC8832510__F2 Forkhead Box Family in Bone Metabolism and Diseases 6714 6648 2308 7189 9242 302 94234 2296 27086 1499 2303 650 652 27022 4086 4488 468 2294 3170 860 PMC8833225__F4 Cathepsin family target genes in phagosomes 8417 9341 83547 203068 200576 4074 4353 811 53407 7097 7099 10333 8685 948 718 929 PMC8833570__F1 KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative Disorders 2475 4193 930 4067 974 973 6850 4763 613 695 29760 2885 5336 PMC8835757__F6 Transcriptomic Profile of Canine DH82 Macrophages Infected by Leishmania infantum Promastigotes with Different Virulence Behavior 1435 4254 2255 3679 3676 613 6850 930 5879 27159 5728 951 7249 5810 572 4193 6009 672 5934 150365 1977 PMC8835790__F1 Epigenetics in the Diagnosis and Therapy of Malignant Melanoma 4524 4548 4552 635 875 191 2593 1312 27232 262 29128 4255 6723 6611 383 4953 54498 PMC8835863__F1 Apoptosis during ZIKA Virus Infection: Too Soon or Too Late? 8772 331 637 468 22926 7494 PMC8835992__F8 Thyroid Hormone Receptor A Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis 1499 54567 79800 9209 441478 1956 221937 3148 6469 2305 6925 6955 56950 331 6659 2932 8454 9978 2274 27086 6664 6996 10856 23426 7015 8538 PMC8836182__F1 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC 1499 3480 572 7249 7248 1956 5728 9429 5066 PMC8836812__F3 Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis 367 1839 7040 7076 7039 2247 3603 3574 1356 5155 3458 6356 3576 653 4254 1956 1440 6351 6348 3586 4803 3593 3605 1437 2249 3592 3600 4804 7422 3589 7124 5154 3082 2252 4049 2324 5281 84432 652 6369 7077 655 4909 2688 3606 4283 6347 6346 4908 3558 3630 1950 4055 3596 3815 3565 1435 3479 4982 3383 2277 627 1436 3552 PMC8836812__F4 Unraveling the Signaling Secretome of Platelet-Rich Plasma: Towards a Better Understanding of Its Therapeutic Potential in Knee Osteoarthritis 1356 7076 4982 3603 367 7040 3586 3574 3600 7132 10563 3576 3383 3487 7043 6351 9518 1956 3486 4804 7124 653 1437 4055 4049 3489 84432 6369 652 5281 3485 6346 2324 3484 6359 4283 655 6347 3569 3596 7077 6352 3815 2688 3565 3589 3146 PMC8838174__F5 In Vitro Anti-Cancer Activities and Mechanisms of Action of 9-Methoxycanthin-6-one from Eurycoma longifolia in Selected Cancer Cell Lines 57448 637 4170 355 302 27429 7124 581 2620 790 6093 3958 56616 54205 317 2021 572 3178 2597 PMC8838622__F1 An Emerging Role of Defective Copper Metabolism in Heart Disease 4015 1356 6647 475 538 540 PMC8838632__F2 Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest 2475 8408 581 596 317 983 1017 1021 1019 PMC8840228__F2 Muscle stem cell adaptations to cellular and environmental stress 468 1998 2147 PMC8841363__F2 Network based systems biology approach to identify diseasome and comorbidity associations of Systemic Sclerosis with cancers 6525 1910 714 712 9332 2919 11326 7056 2920 2921 4481 929 50486 4360 22918 3569 51338 713 122953 54498 217 4953 196743 55256 6611 79814 4507 113451 8515 7204 1307 1290 4320 1293 1303 1300 5569 2805 6723 8639 55328 6303 1292 1297 29894 84795 89795 51074 5570 55599 262 112483 11142 PMC8841737__F2 Noncoding RNAs in Drug Resistance of Gastrointestinal Stromal Tumor 6774 55102 2475 100124700 26469 5163 5728 137196 3480 4485 9113 26524 4193 581 3815 PMC8842010__F4 Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data 7410 7074 5879 5880 7409 5881 5058 10451 3265 3845 5894 5605 5604 5595 5594 5159 5156 2264 2261 2260 2263 5291 5296 3562 6655 6654 3563 1439 8503 23533 5577 5567 1956 4803 4914 5290 5294 5576 3645 5566 5568 369 10000 207 208 5898 5899 572 5609 6416 1147 3725 4792 3551 10928 5337 4790 5970 5535 5534 5533 5532 998 598 PMC8842579__F3 Battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies 7097 7189 7099 7098 7187 29110 3661 57506 64170 8915 10892 6850 163702 3588 3454 3455 7297 3716 6773 6772 8519 10410 9023 3433 3434 6041 10379 4061 2194 9829 26010 81030 9334 1997 PMC8844485__F3 Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting 3146 142 5970 613 84875 472 3553 3383 PMC8850260__F8 Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NFKB/HPSE1 Signaling Pathway During Inflammation 7099 7412 6382 PMC8851529__F2 Alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents 183 59272 5476 4295 1359 4311 5972 1215 1511 1636 5547 5550 116512 PMC8851529__F5 Alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents 7099 2475 6774 5163 1977 7428 8453 2056 7018 7037 1950 1906 3162 5211 2597 226 PMC8851862__F3 Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat 84309 472 7157 6741 983 1021 1017 1019 545 79858 993 5888 1763 PMC8856834__F3 Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis 7077 693168 406952 406961 8945 57214 331 6662 407040 406958 574038 693201 PMC8859461__F1 Type-I Interferon Signaling in Fanconi Anemia 22909 57697 3398 55215 2177 2176 2178 2175 2187 55120 2189 80233 199990 91442 100187761 PMC8863963__F14 Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer 8417 9341 83547 203068 200576 4353 811 7097 7099 10333 4015 8685 948 929 PMC8864109__F6 lncRNA Mirt1: A Critical Regulatory Factor in Chronic Intermittent Hypoxia Exaggerated Post-MI Cardiac Remodeling 143187 23440 847 8819 367 9839 1262 6310 27161 651 6010 5079 64388 3624 285 284217 249 248 5962 10382 PMC8864228__F2 Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases 2668 361 3553 718 6098 366 PMC8864631__F7 Therapeutic siRNAs Targeting the JAK/STAT Signalling Pathway in Inflammatory Bowel Diseases 3716 3718 100187761 3458 PMC8866866__F1 Nerve Dependence in Colorectal Cancer 4312 4316 1956 4513 2668 4318 627 4803 1000 PMC8867096__F2 Unraveling Muscle Impairment Associated With COVID-19 and the Role of 3D Culture in Its Investigation 59272 3479 1401 PMC8869601__F6 Potential Citrate Shunt in Erythrocytes of PKAN Patients Caused by Mutations in Pantothenate Kinase 2 2821 2539 3417 48 2805 47 79944 80025 PMC8873123__F3 Autophagy plays a double-edged sword role in liver diseases 2475 3146 9776 1788 10533 7045 79065 9474 9140 PMC8875462__F4 Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice 9350 147111 50964 59352 8549 55366 25805 6259 27130 324 6477 6500 387 9978 25776 4089 4088 51701 4316 PMC8882872__F3 Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease 4088 405 196 4312 3620 59272 7045 1636 10135 PMC8883456__F6 Main repair pathways for trapped topoisomerases in humans 6047 90933 7150 8940 55775 4361 93953 83932 63901 51567 26036 142 PMC8888700__F5 Environment-dependent oncogenic activities of PcG proteins 6256 351 2624 55840 9055 6347 4277 100507436 729230 PMC8888851__F1 Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity 7808 9518 260431 59272 3458 4855 7054 PMC8891342__F1 Impact of intracellular innate immune receptors on immunometabolism 3101 3099 3098 2821 229 226 5209 2597 1376 PMC8891559__F1 Necroptosis in alcoholic liver disease and hepatic pathogenesis 3146 3454 8772 23118 10454 8737 197259 2919 2920 8717 7186 1540 11035 7098 7099 1612 114548 81030 5495 PMC8891559__F2 Necroptosis in alcoholic liver disease and hepatic pathogenesis 8737 1571 11035 197259 3146 5700 8473 5683 2717 PMC8891817__F18 Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling 11074 114548 3553 3627 1728 2730 2729 4087 4088 1277 PMC8892134__F1 Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer 6774 3479 3481 3480 2885 6009 3643 7249 7248 5728 5163 4485 9113 26524 6010 2621 27 558 PMC8894702__F2 miR-1269a and miR-1269b: Emerging Carcinogenic Genes of the miR-1269 Family 3064 7157 842 51362 836 4092 6659 100302177 100616494 3236 79987 9182 5728 PMC8897452__F7 Colorectal liver metastasis: molecular mechanism and interventional therapy 7852 4087 4088 4089 6935 6774 PMC8898094__F4 Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling 1629 10469 3310 10134 7266 3998 10493 10618 23481 51116 5538 283742 80142 23112 8661 27250 6157 8666 8662 4478 51663 8894 5936 207 3313 79026 7415 5931 1387 5036 11331 51631 5518 2597 1666 9318 11128 8021 5434 4175 3329 6118 10921 9532 51010 3848 1374 1956 8665 2040 493 60412 3842 10916 23223 3956 10111 160 960 5091 9219 5130 8140 4363 9782 92140 9382 2495 2222 9373 81627 54888 23155 10318 23196 6510 8879 490 3105 5706 11047 5704 6400 8050 9218 6286 1656 114793 5160 5315 5093 6727 7001 2521 6184 5230 3190 8833 1373 1603 3344 27044 4172 1982 6188 23451 9053 4176 4926 821 9208 79733 10155 10915 57805 55832 6596 60 90268 2033 50814 1312 1108 23420 9554 8801 22872 3611 9524 8301 79577 10294 3688 1654 71 1665 29927 26993 57003 51614 10946 24148 23435 51593 79869 6626 8106 988 5411 8540 2956 10066 55705 10952 23011 5870 10672 4976 26130 1743 84263 6277 5095 2821 113146 372 6838 7163 80230 5355 9521 54913 PMC8899708__F5 New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology 958 1326 4314 4312 PMC8903693__F4 Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them? 317 4193 355 581 983 1869 1017 1019 PMC8905560__F4 Prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis 7097 23118 51135 114609 4118 929 4615 7189 3656 3654 10454 257397 1431 7099 847 941 969 3383 942 958 9308 PMC8908322__F3 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? 367 3084 1950 685 4804 8301 3297 8633 2638 9140 2624 1956 PMC8908994__F2 Noncoding RNAs in Cardiac Hypertrophy and Heart Failure 406990 2626 4205 112597 9641 9927 3205 4615 406996 104564225 9842 PMC8909699__F2 Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy 6736 693230 11063 6659 94234 6662 112869 6666 581 6387 9982 6657 6664 6651 693223 55384 55553 2475 283120 1540 1499 9580 503638 30812 83595 64321 54345 27086 9429 8324 595 10818 2264 2324 PMC8914285__F3 New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases 1236 7099 4615 51135 3654 7189 3656 6363 7409 PMC8917703__F2 Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation 324 5970 3383 7412 29110 940 115004 146223 3627 811 2146 5027 5029 2833 7099 3454 PMC8919059__F5 Genomic And Tumor Microenvironment Differences Between Cell Cycle Progression Pathway Altered/Non-Altered Patients With Lung Adenocarcinoma 3273 1361 5053 2638 816 11075 6694 1141 3952 796 51156 51083 1401 29114 1995 6616 4852 1103 6441 3852 479 213 4744 9900 887 495 653509 6439 6524 3158 229 7356 2297 6703 6705 6704 6700 6706 23581 3263 259 4922 2290 4915 6456 132204 5320 PMC8923340__F3 COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines 7113 59272 11213 7189 5045 4615 8829 51311 51284 23118 10454 7098 7187 3661 3665 23586 29110 3576 4283 920 PMC8924072__F6 Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy 6139 1537 498 5829 253260 6192 8192 506 5684 513 3419 2597 9370 226 PMC8924130__F4 Glioma: molecular signature and crossroads with tumor microenvironment 546 4763 5728 4015 4255 5925 1019 1021 3417 1956 10413 2475 4117 6347 729230 7124 PMC8924581__F2 Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators 1022 1025 948 1020 10011 9619 19 23411 63976 7341 383 PMC8926903__F1 Genomic and transcriptomic landscapes of clock genes reveal the significance of circadian rhythm in the progression and immune microenvironment of metastatic colorectal cancer 6097 6096 8863 5187 9975 9572 4862 1408 9575 23746 1407 367 PMC8927697__F4 Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic Strategies 4513 4512 3146 PMC8927970__F1 Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity 114609 4615 51135 3656 3654 7189 23118 257397 7100 7099 7187 29110 3661 3665 7098 51284 7186 51311 54106 PMC8928114__F4 Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics 7124 8717 7186 6774 3566 3575 3718 3716 50615 149233 7297 3717 PMC8931289__F9 Tear miRNAs Identified in a Murine Model of Sjögren’s Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism 10673 2531 3304 3303 10903 9993 3120 8862 2247 4860 5257 5713 55037 90809 10180 9931 55273 55602 27111 85451 402 29842 9045 3929 367 993 8556 899 929 1534 5595 958 4975 134353 84144 27351 161742 1111 595 898 894 10912 55038 7189 54443 100272147 10621 22926 57088 382 3643 10000 2260 7186 57167 255488 205 55869 4602 6096 9261 51527 838 26017 7037 1033 4697 2029 117143 596 4883 57379 23261 2904 157807 284613 1401 143384 152110 4170 2885 3717 6774 2 8651 9021 PMC8931761__F1 Traditional Chinese Medicines as Effective Reversals of Epithelial-Mesenchymal Transition Induced-Metastasis of Colorectal Cancer: Molecular Targets and Mechanisms 5741 4089 4087 4088 2475 9839 6935 1499 2932 999 1000 PMC8940216__F5 Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis 4615 3553 7124 729230 PMC8942208__F3 Differentially expressed components of four of interesting pathways involved in immune response and drug metabolism in F. gigantica-infected hLNs and pBLs 2941 4129 130 221 2940 8061 27306 2327 2326 5743 4353 5063 112744 3593 629 6372 913 3929 7124 2921 3606 3569 255189 4312 3552 1232 2243 566 3596 3565 9437 2814 51561 3625 3627 6300 3976 6361 4318 PMC8944478__F6 Identification and Molecular Analysis of m6A-circRNAs from Cashmere Goat Reveal Their Integrated Regulatory Network and Putative Functions in Secondary Hair Follicle during Anagen Stage 23365 1634 3688 2033 8453 367 54331 324 2261 3673 3949 4090 5728 51176 4093 196 100653366 10645 7534 673 5332 122786 4756 5054 25937 595 817 1740 3236 6383 10000 5978 6498 1869 5308 25805 6934 650 6387 23236 1948 5533 7048 7422 1386 659 1385 7473 PMC8944741__F7 Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases 23621 3553 581 627 590 847 4025 43 PMC8945049__F4 Differential Transcriptome Profiling Unveils Novel Deregulated Gene Signatures Involved in Pathogenesis of Alzheimer’s Disease 2596 9135 7059 780 10677 91807 7532 3693 7170 55845 801 51719 22895 70 60 4057 488 6855 1373 6622 4293 23028 334 8440 5579 3945 51592 2033 175 171568 5829 4190 8655 284391 2664 3761 2892 9001 7327 25821 1175 8732 51606 5440 6391 6390 1432 998 5451 2561 7328 8454 324 8473 9616 6872 2847 2776 5999 PMC8945446__F2 Therapeutic Approaches Targeting Proteins in Tumor-Associated Macrophages and Their Applications in Cancers 5170 5230 3717 6774 4313 8205 388796 2475 6362 4015 6696 5728 5281 10384 10457 1499 57761 6657 4316 4318 1000 90865 9173 3479 6347 7099 PMC8946235__F1 Targeting the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Colorectal Cancer 4436 2956 4292 5395 9156 5111 4149 142 5423 6741 2067 675 79728 5888 672 PMC8946535__F1 From Biology to Treatment of Monoclonal Gammopathies of Neurological Significance 695 51135 3656 613 4067 6850 29760 5336 5728 PMC8946552__F2 Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications 3082 5728 7248 7249 6009 7942 7030 4286 3162 96459 57600 201163 2056 9978 8453 9817 1956 2271 6391 6389 6392 6390 2242 8314 55193 6598 1029 1030 1019 1021 PMC8946661__F5 Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer 6839 2737 2735 6469 8900 595 80854 898 7422 4313 7291 7161 PMC8946769__F2 NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation 9817 8452 2730 2936 2729 23657 2539 7295 7296 1728 3162 PMC8949786__F6 Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning 999 468 4628 1499 4791 5602 6300 55742 595 253260 7431 5881 58480 5594 4609 7132 5520 60 2317 3688 9586 8440 4651 54751 4627 2353 3875 51176 10398 30849 87 1832 3694 390 5295 3696 81 5747 5296 4637 1072 7424 89941 PMC8950196__F6 CDH1 Germline Variants in a Tunisian Cohort with Hereditary Diffuse Gastric Carcinoma 999 324 2932 1499 PMC8950345__F1 Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy 57697 80233 2178 79728 91442 199990 675 55215 2177 3398 4361 142 PMC8954493__F7 Gene Expression over Time during Cell Transformation Due to Non-Genotoxic Carcinogen Treatment of Bhas 42 Cells 5723 1719 7298 39 3652 3422 29968 6470 3158 4597 2222 4522 10797 26227 6713 PMC8955777__F8 Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial–Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells 7248 7249 2064 1950 3725 2353 PMC8956559__F4 Adipose tissue: a neglected organ in the response to severe trauma? 1675 7097 3146 7124 3553 7018 7350 PMC8960167__F1 Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy 317 355 581 1687 79792 7124 1540 197259 PMC8961331__F4 Interplay Between TGFB Signaling and Cell Metabolism 262 4953 383 PMC8961445__F2 Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators? 7099 613 6774 3091 6850 54106 4615 PMC8962344__F2 Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery 7428 790 3939 50808 5230 2056 596 PMC8966870__F2 ILC2s can contribute to tumour rejection or tumour growth 2920 3576 90865 10219 6352 999 383 PMC8971914__F1 Interactions of circRNAs with methylation: An important aspect of circRNA biogenesis and function 56339 54915 51441 79068 91746 23060 253943 1982 10482 PMC8974835__F1 Pharmacological Rationale for Targeting IL-17 in Asthma 7189 729 3717 2247 1956 4851 PMC8979719__F7 Comparison of Three Species of Rhubarb in Inhibiting Vascular Endothelial Injury via Regulation of PI3K/AKT/NFKB Signaling Pathway 7015 5447 2475 4193 7157 2247 3320 7124 4313 6790 5743 5290 6714 3569 3815 4353 4318 1956 6774 6868 596 4846 367 1636 239 2064 6403 4324 2099 4843 5468 213 5328 7422 PMC8981989__F2 Glucose, Fatty Acid and Amino Acid Metabolism by Ubiquitination and SUMOylation for Cancer Progression 6613 29843 3091 10054 10055 3939 226 2597 2023 7189 5209 6737 10273 56254 9810 81559 23326 78990 324 999 7428 128439 PMC8982327__F1 Targeting transforming growth factor‐B signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin 331 4089 4087 4088 2475 PMC8983667__F1 Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway 2798 2778 107 9985 PMC8983758__F2 Feedlot diets containing different starch levels and additives change the cecal proteome involved in cattle’s energy metabolism and inflammatory response 3098 3099 3101 2645 5213 5211 5214 26330 2597 5224 5223 3939 3945 3948 7167 5105 6513 6514 6515 6517 6518 2821 2203 8789 226 229 230 5230 5232 2023 2027 2026 4190 51660 25874 5091 5160 5161 5162 1737 1738 8050 2806 4191 PMC8984190__F1 Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer 6714 4058 9052 5331 PMC8988234__F2 Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance 2936 2879 10162 4015 3652 55240 7018 7037 1723 PMC8990771__F3 Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer 2475 1950 1956 6774 581 PMC8990993__F5 Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus 8717 8772 637 3579 PMC8992553__F2 Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications 56616 581 331 637 8772 PMC8993538__F12 Optophysiology: Illuminating cell physiology with optogenetics 1408 10519 4827 581 1956 6774 10413 PMC8995746__F1 Targeting NLRP3 Inflammasome With Nrf2 Inducers in Central Nervous System Disorders 114548 10628 4513 4094 9817 PMC8996682__F6 Blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments 1524 942 1235 9332 4035 6376 7099 4615 1499 114548 581 140609 58157 3383 7412 PMC8996999__F1 Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment 7422 3091 7040 160728 7078 1612 7173 7253 4485 2309 PMC8998738__F8 Dual Anti-Inflammatory and Anti-Proliferative 3-Styrylchromone Derivative Synergistically Enhances the Anti-Cancer Effects of DNA-Damaging Agents on Colon Cancer Cells by Targeting HMGB1-RAGE-ERK1/2 Signaling 3146 729 983 581 331 PMC8998814__F3 Metastasis and MAPK Pathways 1956 1950 2885 2475 2303 10716 4087 4088 4089 7189 6010 998 PMC8998991__F4 Mammary Gland: Basic Structure and Molecular Signaling during Development 6010 5618 2690 3479 3480 5617 6772 6774 3082 51199 2625 2932 759 6926 374 1956 6868 3397 10718 780 5741 652 PMC8999734__F4 Anti-Inflammatory Activities of an Anti-Histamine Drug, Loratadine, by Suppressing TAK1 in AP-1 Pathway 7099 4615 4314 4318 4312 PMC9001149__F10 Signaling pathway and molecular mechanisms underlying TLR/zVAD-induced autophagic cell necroptosis 7099 4615 7098 29110 3661 3716 7297 6772 PMC9004513__F1 MTORC1 Activity by Amino Acids and Growth Factors 4864 153129 652968 201163 64223 2475 10445 6009 7249 7248 51256 PMC9006080__F5 Molecular Signatures of Mitochondrial Complexes Involved in Alzheimer's Disease via Oxidative Phosphorylation and Retrograde Endocannabinoid Signaling Pathways 9861 91860 10888 8326 7280 7277 7132 6622 6263 107 57142 113 196883 5707 5701 5690 5684 5534 6389 5530 6390 3708 1345 7386 4706 25825 1131 203068 10313 10213 1020 51606 526 528 529 245973 8992 537 5464 PMC9009033__F3 ARID1A variations in colorectal cancer: a collaborative review 3845 196528 2002 55294 5926 8289 57492 5290 2475 6790 5347 324 PMC9010872__F1 O-GlcNAcylation and Its Role in Cancer-Associated Inflammation 2821 2673 5238 6675 8473 10724 PMC9017388__F6 SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells 6198 207 572 5515 5295 5170 208 5595 2475 5578 1978 84335 5564 5562 7249 1981 1977 PMC9019162__F3 Genome-Wide Association Study for Tolerance to Paratuberculosis Identifies Candidate Genes Involved in DNA Packaging, DNA Damage Repair, Innate Immunity, and Pathogen Persistence 5620 58531 5619 7142 7124 840 9586 7188 1147 8651 4261 7042 2067 PMC9020266__F1 Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair 11284 7518 286257 5893 472 672 675 79728 641 5888 PMC9021207__F2 Associated immune metabolism in the tumor microenvironment 3845 383 8205 PMC9025063__F4 Genome Integrity and Neurological Disease 5423 7515 142 5111 2237 3978 PMC9025063__F6 Genome Integrity and Neurological Disease 9156 5932 472 675 5888 641 1763 80198 146956 7518 3981 286257 PMC9027775__F5 Human RelA Transgene on Murine Macrophage Inflammatory Responses 11314 6307 6713 4283 149628 3683 6382 3383 163351 3627 9497 92369 80176 390 11326 3437 6361 2669 23013 629 3434 3433 221656 7128 9246 2635 2167 10892 10392 8767 6737 10062 196 7431 2634 9935 867 6714 952 80223 5468 3554 3552 4094 201163 4085 115362 7280 1050 8440 2353 1052 857 858 5743 1026 7422 3717 3659 5008 7006 100124696 1910 9265 30061 23150 5430 23645 23498 1478 7046 6401 598 57530 84868 9414 79132 PMC9028769__F6 Human Papillomavirus 16 E6 Suppresses Transporter Associated with Antigen-Processing Complex in Human Tongue Keratinocyte Cells by Activating Lymphotoxin Pathway 7018 4055 6890 6891 PMC9031331__F4 Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in HIV-Associated Neurocognitive Disorder 238 27040 6387 100126327 22854 84890 1948 2534 1942 6469 655 1630 8829 5747 5770 5058 6237 27289 3265 387 55740 5590 7975 PMC9031497__F4 Impact of Maternal Feed Restriction at Different Stages of Gestation on the Proteomic Profile of the Newborn Skeletal Muscle 5226 5213 178 2597 2026 5315 5160 1737 1738 5132 3419 4967 1743 1892 48 3417 2752 PMC9035666__F4 Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension via STAT3/HIF-1A/VEGF and FAK/AKT Signaling Pathways 7157 5595 5594 7124 3725 4609 5290 6774 5295 1432 2099 6714 207 5970 PMC9037064__F3 Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells 1499 6925 4088 4087 25805 4089 650 2195 100750225 1432 406991 3716 6774 6772 4853 PMC9037237__F5 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction 2475 7124 3479 1855 2885 3551 673 3265 7248 57600 6009 5728 6502 1147 6396 64798 9894 83667 2887 387 6446 PMC9037237__F6 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction 7124 355 8717 3265 6654 998 7186 23118 51295 3240 1616 369 5894 5604 351 57136 1147 1844 2872 5530 4790 468 2002 4609 3727 1386 7157 4149 4208 3315 3164 2353 PMC9039039__F7 Research Progress of Exosomes in Bone Diseases: Mechanism, Diagnosis and Therapy 5858 10140 867 53366 PMC9040700__F2 High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons 114548 6772 7097 59272 PMC9043558__F1 Ror-Family Receptors in Development, Tissue Regeneration and Age-Related Disease 4919 4920 2316 7474 5548 6964 PMC9043600__F1 Long Non Coding RNA Based Regulation of Cerebrovascular Endothelium 440823 55384 100124700 7503 55000 283131 285908 596 100507246 581 378938 9706 5820 5058 10533 6774 8420 7422 23642 285958 79104 3091 PMC9043895__F3 Corrigendum: The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation 9055 6886 580 672 165918 9025 4199 4200 10873 3065 3066 22992 6419 54799 9682 79728 26013 7415 5888 PMC9046588__F6 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy 324 2932 1499 2885 10419 55170 6654 5894 5728 5163 4609 3091 468 PMC9061764__F3 Mechanism identified for ketamine and/or (2 R, 6 R)-hydroxynorketamine (HNK) 2475 3399 3400 3397 3398 9294 10135 PMC9065266__F2 Inflammasomes in Cancer Progression and Anti-Tumor Immunity 6476 114548 8205 85480 22861 171389 58484 9447 3579 619501 PMC9066101__F2 Smad3 Signatures in Renal Inflammation and Fibrosis 1401 940 4089 50943 4087 4088 920 PMC9072026__F1 Intertwined Relation between the Endoplasmic Reticulum and Mitochondria in Ischemic Stroke 581 100506742 468 842 22926 PMC9081902__F2 Processing of dietary lipids for chylomicrons synthesis 7038 4547 337 5311 948 335 10139 4018 64853 160518 PMC9084550__F2 Signaling pathways and therapeutic approaches in glioblastoma multiforme (Review) 1950 1956 2885 8826 324 595 1499 51176 6929 PMC9086853__F12 Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells 3098 2821 5213 230 226 2597 2539 25796 5226 5230 2023 2936 5723 5315 PMC9092946__F1 Endoplasmic Reticulum Stress and Its Role in Homeostasis and Immunity of Central and Peripheral Neurons 22926 114548 83939 468 3553 847 79792 4609 3091 3661 PMC9096207__F4 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination 729230 948 2167 3577 6774 PMC9098327__F4 Cross-Talk between Polyphenols and the Target Enzymes Related to Oxidative Stress-Induced Thyroid Cancer 1728 847 4094 9978 8452 196 PMC9100302__F1 An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19) 59272 7808 51199 PMC9102675__F2 Endothelin and RAS/ERK signaling in immunopathogenesis-related fibrosis in patients with systemic sclerosis: an updated review with therapeutic implications 2475 3265 3717 PMC9104295__F3 Procyanidins and Their Therapeutic Potential against Oral Diseases 2475 572 4087 999 4851 PMC9104818__F5 Bone Progenitors Pull the Strings on the Early Metabolic Rewiring Occurring in Prostate Cancer Cells 5725 5798 6815 80727 8985 55593 7127 10978 80146 1073 3329 3630 80208 3956 53366 948 8741 1200 637 1311 64112 10451 1490 6678 7498 9697 2053 10631 51780 1962 7422 1387 50944 9877 9228 5294 3684 7045 64857 27175 83658 9920 8831 57186 4599 8412 22873 781 5567 5566 2335 5576 100506392 6385 57605 55754 4089 4087 4088 2876 665 56975 1471 1842 8904 9236 6717 9863 4677 718 4113 54910 4060 80319 410 8139 84623 9902 25900 9507 7421 1629 10799 8924 5465 57419 3099 1147 4803 861 9770 206358 5901 399909 602 468 4783 81537 197 25839 83715 9681 720 2056 6648 202915 415116 6464 60681 57537 PMC9104939__F6 Recent Advancements in Antifibrotic Therapies for Regression of Liver Fibrosis 3479 3480 407021 10000 1490 7099 54106 7046 596 7048 4087 4088 PMC9108976__F2 Cellular and Developmental Roles of Cullins, Neddylation, and the COP9 Signalosome in Dictyostelium discoideum 4738 123228 7345 7347 55832 9978 9040 8883 140739 54165 8453 8454 8451 8452 8450 8065 23113 9820 1447 1448 729 PMC9110871__F3 Viral and cellular translation during SARS‐CoV‐2 infection 7098 7187 29110 3661 10482 29107 3665 6772 6773 3716 10379 3454 3455 100187761 PMC9112566__F1 Endomembrane remodeling in SARS-CoV-2 infection 7113 59272 1514 1508 PMC9113089__F2 Glioma and the gut–brain axis: opportunities and future perspectives 3553 5697 885 PMC9116428__F1 Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NFKB Signaling Pathway 627 7186 7187 8717 7189 8772 7099 4615 5052 51295 942 941 3576 6347 2475 PMC9118284__F3 An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways 8772 836 842 581 10533 PMC9120235__F4 OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization 7124 8772 958 8567 8600 959 6714 8717 10454 23118 54472 4615 5606 5608 114609 6416 5609 PMC9121642__F2 Compound Kushen injection inhibits EMT of gastric cancer cells via the PI3K/AKT pathway 10855 4133 847 5468 2100 5447 1869 31 5328 367 83540 3725 9961 6720 43 351 3099 5327 100187761 1147 4609 5569 4350 2920 6401 1509 581 7422 5111 3606 1576 2475 3627 PMC9122124__F2 Macrophage: A Cell With Many Faces and Functions in Tuberculosis 7099 6772 572 4283 3627 2919 9314 6778 6774 384 95 PMC9127837__F5 Mitochondrial DNA Instability in Mammalian Cells 9941 3980 4595 4968 252969 4913 79661 1763 2237 5426 672 4361 5888 PMC9129976__F3 Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway 367 4353 4313 4350 2100 4363 1565 5836 1612 1956 9133 847 4170 6714 6462 5294 7153 5743 2859 4638 5742 2170 6097 1509 1588 5747 5581 2101 6850 2167 873 2147 377677 23632 9212 196 80351 4322 3791 23621 239 771 590 3643 5802 238 351 4137 558 5467 10054 10062 4751 6046 PMC9129976__F4 Fructus Mume Pills Underlying Their Protective Effects in Rats with Acetic Acid-Inducedulcerative Colitis via the Regulation of Inflammatory Cytokines and the VEGF-PI3K/Akt-eNOS Signaling Pathway 196 5742 4313 4318 4314 5743 4843 2147 5465 759 3643 5468 873 6097 5243 2099 9429 4353 5802 2859 1956 PMC9130585__F2 Pathophysiology of Primary Cilia: Signaling and Proteostasis Regulation 80184 22994 9971 5108 11004 8481 585 4627 6469 51684 11020 79848 152110 5727 1956 PMC9130956__F1 Atypical Cadherin FAT1 Limits Mitochondrial Respiration and Proliferation of Vascular Smooth Muscle Cells 2195 11319 1950 PMC9134136__F2 Ductular reaction in non-alcoholic steatohepatitis 4485 60485 9113 26524 1499 6608 2737 2736 3082 PMC9134593__F1 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases 4615 51284 51311 54106 7097 10333 7100 4118 51135 3656 3654 7189 23118 257397 10454 7099 81793 3553 7187 7098 3665 29110 PMC9134690__F3 Effect of berberine on global modulation of lncRNAs and mRNAs expression profiles in patients with stable coronary heart disease 5901 8731 6197 79813 54797 6638 26121 1655 10594 1051 1649 5440 23020 23426 5436 8726 27343 11201 7391 5434 2099 57167 1822 5700 1108 6636 9040 6635 51585 5683 4738 5716 64714 8312 10949 9734 5087 5696 PMC9138253__F3 Cross-Talk between Wnt Signaling and Src Tyrosine Kinase 324 1499 2932 4040 4041 6714 387 4920 4919 7204 998 7431 PMC9138619__F3a Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids 4049 695 9020 29760 7292 8742 8995 51330 602 1896 10913 5971 4791 7124 650 3725 2353 2920 3627 6373 2921 6387 2833 7852 10850 6356 6364 729230 1236 10379 3665 6401 7424 2277 3569 9021 2324 80310 4067 1440 1435 4314 5743 2056 5008 2057 3716 3717 1325 344901 5328 3977 5340 3606 79792 834 PMC9138696__F1 Stressing the Regulatory Role of Long Non-Coding RNA in the Cellular Stress Response during Cancer Progression and Therapy 7518 283104 6935 472 1958 108570035 3190 1869 729177 4609 378938 100124700 6117 PMC9138746__F3 Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer 2 1012 2821 2932 6997 5163 5347 8772 PMC9139581__F5 Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors 6295 570 1508 3066 3606 3091 292 6584 2026 6658 5213 3939 5465 PMC9144222__F10 Crassolide Induces G2/M Cell Cycle Arrest, Apoptosis, and Autophagy in Human Lung Cancer Cells via ROS-Mediated ER Stress Pathways 83939 468 891 581 836 PMC9146752__F1 Research Progress on Transorgan Regulation of the Cardiovascular and Motor System through Cardiogenic Exosomes 8470 10611 2066 3654 406992 406921 27250 7251 29965 PMC9156618__F2 Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome 929 4210 7099 4780 4353 3115 7128 3146 1508 29108 836 51284 114548 834 1514 3456 3106 9636 3119 3458 3627 29126 3586 3105 5133 920 6348 1440 2324 2056 7422 1437 3516 3559 3576 695 51517 930 5594 59272 340024 5707 183 3630 4311 2475 185 1636 1506 5563 958 682 3575 5045 5562 5972 868 2147 9146 1576 11093 3574 2215 1431 2159 186 2152 412 2214 9509 5327 7450 5340 PMC9156734__F2 PI3K/AKT signalling pathway in CECs 7442 6194 6714 1950 7249 1984 5111 4609 5728 3486 8660 572 581 3479 3480 3643 5829 PMC9156734__F3 Roles of different molecules related to the PI3K/AKT pathway in CECs in diseases and therapeutic strategies 8660 3479 3480 23411 6714 7873 1950 3082 581 3603 3146 8091 4827 7942 PMC9159374__F3 Amelioratory Effect of Resistant Starch on Non-alcoholic Fatty Liver Disease via the Gut-Liver Axis 7038 5697 7099 8213 PMC9162455__F1 Down-regulation of MHC-I antigen processing pathway by tumour cells and possible therapeutic targets 4609 3458 84166 6772 3659 100288687 567 6890 2146 1956 2695 3466 121665 27044 114569 23192 PMC9164040__F3 Glance at the Molecules That Regulate Oligodendrocyte Myelination 3084 5728 627 2861 6009 7248 7249 11021 2695 2260 2247 6657 387 PMC9164068__F6 Luteolin on Human Breast Cancer Using Gene Expression Array: Inferring Novel Genes 891 208 1743 90673 4731 376267 57537 3126 1183 3123 171177 54741 9896 3111 255738 158062 10457 3127 7756 7148 151887 7422 3122 3115 5792 5021 22871 351 7097 3491 7042 5534 57214 50964 7060 4018 2246 3075 7057 PMC9164338__F5 Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses 3162 2730 7296 4835 2936 873 3320 3093 5286 6648 PMC9166526__F5 Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape 6714 2621 558 100133941 23613 3091 405 1499 PMC9168780__F12 Emerging roles of cystathionine Beta-synthase in various forms of cancer 999 47 1499 6670 7291 875 4087 4088 PMC9170601__F3 Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy 466 1386 22926 22809 467 11016 PMC9170863__F4 TEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping systematic review) 999 100124700 11230 1499 51083 22943 558 23471 5163 2475 1644 406989 1956 79923 8195 27035 4088 6657 9314 6774 2335 PMC9173662__F1 Complement pathways 1401 715 716 717 4179 720 721 1604 3078 718 727 7448 1191 1361 1369 1370 3075 PMC9178660__F2 Advances in Immunosuppressive Agents Based on Signal Pathway 7124 8717 7186 7188 7189 3654 51135 4615 54472 5971 7187 4055 4513 PMC9178660__F6 Advances in Immunosuppressive Agents Based on Signal Pathway 5058 5062 998 3727 1616 355 8717 7186 PMC9179306__F5 Identification of the Key Genes Associated with Different Hair Types in the Inner Mongolia Cashmere Goat 49860 11072 7053 54764 116179 7062 7851 51056 435 3162 3713 10105 23645 121391 342574 147183 390792 337880 3857 83896 27006 26291 5333 574414 170680 646480 55507 78990 131578 PMC9179868__F1 Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis 3098 1956 3939 3099 2597 5315 857 3101 91319 11257 55840 9817 22937 PMC9180634__F1 Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide 6772 2261 2885 1267 6662 5225 595 PMC9180951__F5 Review on the Role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals 84329 1811 367 6521 PMC9181511__F2 Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity 2167 7097 3553 3458 6352 6351 6355 6348 6347 6354 4283 3627 3558 PMC9182524__F7 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer 4193 545 2098 1017 1021 596 581 PMC9185696__F1 Interplay of retinol binding protein 4 with obesity and associated chronic alterations 3717 5950 9021 7097 7099 7189 5595 5597 7412 51024 3383 50507 PMC9187795__F3 CD30 Expression in Oral and Oropharyngeal Diffuse Large B Cell Lymphoma, not Otherwise Specified 6722 8717 7186 7188 23118 257397 PMC9192598__F3 Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter 3934 3976 3557 3858 7039 4842 1437 3162 1543 4312 11009 5055 3371 2069 3606 5329 1634 8743 5328 4318 2353 3725 PMC9194156__F2 Neurodevelopmental disorders, immunity, and cancer are connected 4615 114609 51135 3654 3656 7189 7124 6774 PMC9194868__F2 Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity 64802 93100 4860 23057 203447 349565 952 23098 2539 2597 3418 3033 PMC9198488__F2 Key Role of RNA Modification in Breast Cancer 51441 728 6790 9589 29102 10644 8243 2023 999 57721 1499 1000 6781 56339 10642 3855 79068 54915 54890 2697 81849 10643 253943 PMC9199231__F1 Interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms 51701 84962 86 9686 60485 4485 6010 PMC9200435__F3 Metabolic reprogramming in pancreatic adenocarcinoma (PDAC) 3949 3156 6646 4199 47 7157 3845 8140 8501 PMC9201217__F2 Toll-Like Receptors in Radiotherapy- and Chemotherapy-Induced Oral Mucositis: A Concise Review 958 941 942 7097 4615 3146 7099 54106 100187761 7100 6648 PMC9203969__F1 NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches 9817 10763 8452 PMC9204954__F2 Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia 438 15 7166 2328 2326 8942 8564 25801 PMC9206313__F2 RCAN1-mediated calcineurin inhibition as a target for cancer therapy 3480 3479 3576 3579 10887 7422 3589 1827 9603 2638 4117 PMC9207356__F2 Physiological and pathological roles of the Hippo‐YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis 9686 4485 9113 26524 60485 55233 92597 6010 PMC9208207__F5 Transcriptional changes in the peripheral blood leukocytes from Brangus cattle before and after tick challenge with Rhipicephalus australis 920 23765 84818 55540 7187 9618 132014 8717 29110 9641 29761 7189 7188 7186 8772 23118 257397 841 5970 2353 6426 1994 5594 2932 4792 1051 3565 6361 6356 3596 6364 6354 6347 3569 1440 1437 5743 7124 3553 3934 4314 4318 4322 4312 3606 3458 PMC9208818__F3 Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment 1300 7057 54918 8205 90865 1950 1956 PMC9209555__F3 Targeted Sequencing Identifies the Genetic Variants Associated with High-altitude Polycythemia in the Tibetan Population 2056 3717 2057 5649 5747 8115 PMC9218441__F2 Intestinal strictures in Crohn’s disease: a 2021 update 6010 6093 3164 26959 2932 324 1499 3596 4088 64127 6774 9180 PMC9218565__F1 Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy 6774 6935 672 51755 4837 6667 4313 10135 2475 960 PMC9219453__F5 Relationship between Plasma Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Level and Proteome Profile of Cows 83758 8824 5948 5950 7276 7037 64220 5947 7018 2778 7433 5199 718 3075 54331 116 629 1675 117 PMC9220264__F3 Focus on the Contribution of Oxidative Stress in Skin Aging 2876 847 1728 PMC9221006__F3 Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers 2735 2736 1499 595 2475 3091 6662 5230 3939 4313 4318 3716 3458 6774 6667 3659 PMC9221433__F7 Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling 2475 5578 5091 9776 8408 8525 2280 57521 64223 84335 1977 54541 1978 3091 3643 7249 7248 6009 1975 5170 6794 253260 79109 5879 6010 PMC9221436__F4 Targeting Breast Cancer-Derived Stem Cells by Dietary Phytochemicals: A Strategy for Cancer Prevention and Treatment 9314 6657 960 7291 1499 5728 2475 648 PMC9222172__F3 Good and the Bad: Monocytes’ and Macrophages’ Diverse Functions in Inflammation 3586 6774 602 7099 114609 4615 3661 PMC9223566__F6 Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex 8772 572 596 2885 2549 5894 PMC9224161__F2 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain 6513 4199 3939 3099 51660 4190 5091 5166 2806 1376 3418 5465 2744 PMC9224161__F4 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain 6513 4199 3939 3099 51660 4190 5091 5166 2806 3418 1376 5465 PMC9224458__F2 MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal Transition 7939 7046 4088 4087 847 1499 406907 324 PMC9229059__F1 Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach 4878 4624 10672 6722 7408 4846 10000 23439 5894 146850 153 3643 4882 7225 387 5997 23236 3827 2767 5139 3708 5604 79922 6543 2626 4881 5581 572 4879 3667 107 5530 4985 775 4659 6093 163688 490 960 10398 10105 3630 5138 340156 4880 5350 10488 PMC9231436__F2 Next-Generation Anti-Angiogenic Therapies as a Future Prospect for Glioma Immunotherapy; From Bench to Bedside 1499 4041 4040 2147 1956 1950 4254 2322 2323 3082 5300 6010 2932 324 4193 842 572 51083 595 5292 4513 1019 3091 100188776 7039 PMC9234177__F7 Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment 6774 581 920 999 PMC9237413__F5 Proteomic Analysis of Hypothalamus and Pituitary Gland in Pre and Postpubertal Brahman Heifers 1839 2798 4313 1956 2776 2885 3845 998 815 7939 3972 2488 PMC9241288__F2 Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update 9242 4513 627 7422 361 960 2668 PMC9247875__F6 Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells 5591 51129 207 2475 6125 6144 PMC9249764__F4 Effect of VEN incubation on gene expression of apoptotic signaling cascades in SEM (upper panel) and RS4;11 cells (lower panel) 4049 8718 8717 329 1147 3551 8517 4794 4792 4790 5970 27242 7186 8743 8784 4214 6416 3070 7124 598 4170 4193 599 596 581 7157 572 4609 8837 10018 8772 637 54205 5366 666 91653 56616 355 835 3660 3661 3662 3480 3481 3665 PMC9251345__F5 Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19 4976 51024 65018 10533 9049 79087 84920 9474 581 199857 317 56616 27429 2021 PMC9251540__F1 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review 4040 4041 367 324 1499 595 860 4087 2247 6422 80326 2932 PMC9257764__F4 Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) 3630 2308 5163 PMC9257764__F5 Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) 6774 3717 3952 3953 355 PMC9258689__F4 Interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data 3418 3417 5226 2876 2879 6723 5182 51056 5184 2623 PMC9259665__F2 Trends in insulin resistance: insights into mechanisms and therapeutic strategy 2308 5105 47 2645 5163 7249 7248 5140 116236 PMC9259972__F2 Long Non-coding RNA HOTAIR in Central Nervous System Disorders: New Insights in Pathogenesis, Diagnosis, and Therapeutic Potential 83734 114548 117177 120892 100124700 581 2146 8851 3553 627 4615 PMC9263135__F9 Bioinformatics-Driven Identification of p62 as A Crucial Oncogene in Liver Cancer 90268 7157 6932 1311 139285 472 8027 1871 7091 595 5979 4133 9817 4193 4780 8452 55294 5584 5590 PMC9264937__F3 p53 Isoforms as Cancer Biomarkers and Therapeutic Targets 7157 581 5888 3981 PMC9265283__F5a Tissue-Based Proteomic Profiling in Patients with Hyperplasia and Endometrial Cancer 1915 10575 10327 5230 7086 71 1674 5315 3858 PMC9265893__F1 Ferroptosis and Its Role in Chronic Diseases 7018 55240 8031 23657 6520 2879 468 246 1803 7163 100 2182 PMC9266763__F4 Revisiting Regulated Cell Death Responses in Viral Infections 59272 1401 7113 3929 64386 10394 22861 637 11035 197259 581 79792 7297 3716 6773 8717 8772 PMC9268799__F2 Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway 2053 1520 5578 5747 5159 3932 7015 5515 6714 5770 1021 1020 5604 5599 5602 890 1019 983 1017 595 598 367 PMC9270134__F6 Investigation of Molecular Mechanism of Banxia Xiexin Decoction in Colon Cancer via Network Pharmacology and In Vivo Studies 5728 5743 5970 3162 6233 5578 6256 3586 3553 5328 3135 3106 6714 5290 3630 7040 7124 3091 7099 6247 4846 3725 4843 4792 2932 7157 2353 6347 4780 595 2099 9370 7422 2475 1956 1232 183 1910 4318 207 4313 1906 983 1234 367 4312 1571 5599 567 3576 1565 7852 5595 1432 54205 581 596 1277 5594 811 842 841 836 PMC9271168__F2 C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways 54583 7428 9817 8452 4780 4691 3091 2034 7296 405 51421 7157 3298 3297 54541 2081 7494 55054 83734 9709 7873 5611 84447 9474 7975 9140 60673 10533 1998 27102 9451 64422 440275 83939 84919 57551 3725 10985 468 440 1054 79924 9361 54407 472 11200 1026 7158 5496 8493 4193 4194 PMC9271868__F2 Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology 4056 84876 4049 9373 7124 6786 4512 54947 PMC9271914__F1 Gut Microbiota-Bile Acids Axis in the Progression of Non-alcoholic Fatty Liver Disease 1593 9420 9965 2264 1581 8213 PMC9273851__F2 Ferroptosis and Emerging Links to the Pathology of Neurodegenerative Diseases 1723 9817 2879 7037 2512 1719 23657 2643 3652 PMC9275048__F2 Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis 782 784 1282 3371 5747 51196 5335 3685 5330 22801 3672 3566 3675 1311 3679 3561 4893 1399 7059 6696 1292 7094 3845 7450 1284 5331 113026 3688 10672 7148 1278 6714 5333 3691 3680 3587 207 9899 1441 28227 208 23239 10000 1291 7060 3909 1101 3912 960 3690 83660 3908 5196 3455 3590 3570 9180 3588 3460 3597 3454 71 3913 2335 7058 60 3265 83706 7057 5336 1277 1293 8515 1439 3977 3459 3563 1398 7481 9564 6256 79602 9370 51094 4853 6423 6257 4854 4855 1374 10580 2181 2180 376497 5468 2167 5106 10062 948 84335 5770 5290 3643 3551 5601 23533 9021 4040 6422 5296 8322 4067 50964 3055 5792 2064 1855 1856 1857 4915 8660 2885 2475 81029 6424 1147 3717 25759 5295 57521 5159 23411 8517 5293 5291 4804 7010 6850 6655 5879 2182 1593 6319 10999 4023 2247 1435 998 2321 2260 1956 25791 7046 1942 4052 7422 7423 56034 2252 5228 80310 5880 4087 387 5155 7042 6464 5921 4254 7048 4088 4091 PMC9277259__F1 EMT in the DNA damage response, double‐strand break repair pathway choice and its implications in cancer treatment 149840 112441434 54537 10039 55183 200558 286257 7518 142 9025 545 5893 10038 9156 2067 472 672 641 2177 6935 1854 7874 580 675 79728 5888 7291 8505 7515 PMC9279298__F1 Plasmacytoid dendritic cells during COVID-19: Ally or adversary? 59272 7113 57506 3661 5132 3569 941 7097 51135 4615 3665 51284 PMC9280173__F9 Antiproliferative and apoptotic potential of Glycyrrhizin against HPV16+ Caski cervical cancer cells: A plausible association with downreguation of HPV E6 and E7 oncogenes and Notch signaling pathway 595 1019 572 581 PMC9280276__F1 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer 7037 6774 8678 23657 9054 6520 2879 2936 375 2181 2182 25801 PMC9281132__F2 Wnt signaling in colorectal cancer: pathogenic role and therapeutic target 7551 54894 4040 22943 324 1499 343637 PMC9281521__F5 Preliminary Study on Gene Regulation and its Pathways in Chinese Holstein Cows with Clinical Mastitis Caused by Staphylococcus Aureus 51091 7054 5331 4534 3673 4144 3074 57678 10157 28 2778 471 4942 7408 440138 1491 130589 55163 23382 2744 138050 8560 2581 2717 410 9942 3099 1432 18 4659 4638 2218 84890 PMC9283897__F3 Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis 343099 8795 10461 331 23411 26136 83540 55704 5111 11215 27229 9169 84131 84132 10403 6045 3149 2237 23527 9493 3832 29899 9055 5781 5873 2305 4085 7153 2317 51592 10112 11200 79031 890 83990 55681 57182 672 4734 5255 6868 1062 92521 540 9156 1063 51735 3308 29766 9738 6936 2065 25814 55729 60684 6240 4751 1871 2799 23443 130507 5954 23376 60560 55754 22944 51008 79612 PMC9284233__F2 Glycolysis in Innate Immune Cells Contributes to Autoimmunity 6774 383 999 3939 2597 3099 3662 1436 941 958 942 29110 1236 PMC9284696__F2 Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration 3726 4060 23636 25798 5310 727957 7637 60677 91683 2197 56901 55544 285641 5376 1278 5654 1668 7286 124872 3039 10073 54870 28984 5549 8195 57182 84458 4267 4818 25879 12 10645 10613 2108 7431 10861 6235 9415 100187761 10020 1893 1051 55719 63905 56850 9604 7071 26585 65980 728741 1605 64840 54823 10209 9856 5516 6494 55638 5830 PMC9286923__F4 Metabolic Landscape in Osteoarthritis 4314 4322 9507 23411 51547 142 952 22933 4321 10135 11096 4318 5091 657 2475 5230 2539 5728 6662 4312 4843 4609 PMC9291299__F4 Translation initiation and its relevance in colorectal cancer 4040 4041 2932 324 1997 10209 83939 1999 2001 1983 468 1977 137735 1956 2885 1975 27250 5728 5163 7248 7249 6009 PMC9291723__F1 Ferroptosis in Acute Kidney Injury 8314 1728 2495 2879 2182 10162 6303 246 1803 7018 PMC9293517__F5 Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis 6401 1544 5241 5566 2147 2950 43 1129 1017 3778 1128 1131 3643 5294 4846 5770 4312 5644 367 2944 2555 5742 1111 6256 3725 2554 7054 PMC9294232__F1 Research Progress on the Anticancer Activities and Mechanisms of Polysaccharides From Ganoderma 55170 1017 4089 4087 4088 7189 1950 1956 5111 581 999 1000 718 472 4513 5243 PMC9295051__F3 High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential 1499 6662 3159 6667 8312 201292 101928607 595 3643 4513 PMC9297570__F2 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states 2064 1956 3717 55364 PMC9297570__F4 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states 3082 2064 6777 55364 PMC9301043__F1 Pathogenesis of HCC Driven by NASH and the Preventive and Therapeutic Effects of Natural Products 7038 8205 2475 619501 PMC9302595__F1 ET-1 signaling in OPCs 1910 219409 6285 10090 1956 PMC9304296__F2 DNA damage response proteins in canine cancer as potential research targets in comparative oncology 672 79728 675 5888 545 11073 PMC9304635__F2 Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis 3949 1581 1066 64241 64240 23411 255738 3931 7038 29881 19 4023 948 PMC9308931__F8 Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii 7189 7099 114609 695 4615 59307 6761 3661 10010 3394 7098 51311 3665 4513 7124 54106 7096 7097 51135 PMC9311918__F1 mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases 468 581 7942 7249 7248 6009 22863 9776 665 65018 PMC9314012__F2 Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis 3667 7099 4615 3553 7048 4088 PMC9315126__F5 Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target 6101 9531 6102 840 81030 2752 29108 4280 841 1676 1677 836 355 2620 22985 8717 4000 8772 9419 6885 9641 5609 9448 9131 596 7048 PMC9315629__F4 Circular RNA in Brain Tumor Development 8318 5991 57089 2316 4928 9833 8714 5641 2309 7422 4313 2305 221150 PMC9315664__F4 Advances in Crosstalk between Porcine Circoviruses and Host 6774 7266 83939 4615 7186 9021 3553 5066 59307 6667 6773 115004 10146 1081 3661 3665 10013 3839 57506 PMC9316001__F2 Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review 6256 1499 6343 1019 1000 999 7155 1956 6774 2475 PMC9317057__F1 Transcriptional Regulation of the Hippo Pathway: Current Understanding and Insights from Single-Cell Technologies 6010 4771 60485 4485 9113 26524 154796 9344 51347 57551 PMC9318003__F2 Will We Unlock the Benefit of Metformin for Patients with Lung Cancer? Lessons from Current Evidence and New Hypotheses 23411 7249 7248 2064 1950 6009 2475 3091 PMC9319258__F5 Possible Cause for the Differential Expression of a Subset of miRNAs in Mesenchymal Stem Cells Derived from Myometrium and Leiomyoma 1457 64750 1387 4052 387 6667 4609 6885 4838 1874 10163 5933 3371 7448 5591 8515 2335 1301 4193 3693 891 8697 1287 1278 3339 993 6696 1282 1281 1026 7532 256076 10971 960 6385 PMC9319879__F1 Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications 2475 2885 3845 2695 5900 7074 PMC9319879__F2 Crucial Role of Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation: Therapeutic Implications 11186 4485 572 3845 2695 7074 PMC9321586__F3 Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation 9021 3656 7189 23118 257397 10454 3667 8660 7249 7248 2475 10682 595 5879 8195 50488 9261 6773 10379 718 PMC9322890__F6 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) 8717 7186 8737 23411 3654 51135 4615 23118 7189 8195 10892 8915 6774 331 2475 581 9817 842 836 PMC9322890__F14 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) 1956 1950 3717 2475 5728 387 581 317 842 836 4088 6935 PMC9322955__F3 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts 472 545 4193 1021 1019 3627 PMC9325148__F2 Succinate as a New Actor in Pluripotency and Early Development? 4513 4512 717 56670 56947 PMC9326066__F2 Single-Cell Metabolomics in Hematopoiesis and Hematological Malignancies 440 3099 3939 2539 847 445 948 355 3417 3418 4023 6510 2744 PMC9327212__F1 Small biomarkers with massive impacts: PI3K/AKT/mTOR signalling and microRNA crosstalk regulate nasopharyngeal carcinoma 6009 6194 5728 572 581 PMC9335103__F4 Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS 3714 6920 54700 256126 5092 55225 91624 6829 54737 2182 8499 4760 2811 3681 8728 130367 5730 51339 2006 392 4477 23390 58155 3295 3283 55030 1528 838 50511 2531 10537 2317 2627 4254 3693 5684 7421 64116 342184 308 6834 330 5168 64066 2249 152519 3481 10906 26030 3732 1540 6837 2065 3485 5069 1259 6035 956 27044 22890 4967 7436 80149 1191 7941 340152 643 123606 55365 6041 6507 79961 23547 4790 1116 1520 939 51311 91937 3604 220002 7321 9487 914 7164 84064 84516 653361 925 4946 10053 3120 50852 117157 6892 1475 7018 915 8671 89790 23557 387357 1439 917 55217 9760 6120 28959 4000 2745 130589 523 353189 154 3566 5908 1755 79924 83551 153 200879 79949 5284 PMC9335290__F2 CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases 1499 1000 999 83737 27250 10481 5091 595 581 2475 3607 5728 PMC9335447__F6a MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study 650 6464 3791 3815 4915 7422 3458 25805 6651 4117 246751 220134 387 5966 6198 5516 1690 5295 PMC9338659__F4 Frontier progress of the combination of modern medicine and traditional Chinese medicine in the treatment of hepatocellular carcinoma 595 1950 1956 6774 2475 331 619501 9474 581 PMC9343597__F1 Present and Future: Crosstalks Between Polycystic Ovary Syndrome and Gut Metabolites Relating to Gut Microbiota 8213 5697 6462 PMC9352673__F5 Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies 5597 941 948 942 9332 6774 6662 7124 3553 383 2521 PMC9352753__F3 Identification of differentially expressed microRNAs as potential biomarkers for carcinoma ex pleomorphic adenoma 4193 7422 3915 8503 7046 9261 6654 103 27113 10401 8323 6241 7976 5925 5595 2885 8643 6789 7161 8772 1978 1871 2254 894 2113 836 4313 8030 9915 5054 545 405 898 7048 2335 650 7175 5534 2033 2259 2549 7170 6010 1399 5747 4790 3480 25 5914 2260 26060 4149 5062 1050 3845 1956 3688 3091 81 5970 861 5295 4312 596 9618 8324 463 472 7057 3815 83667 900 3326 331 5063 2247 8091 891 2736 64393 595 5743 95 7184 3725 5578 7157 1284 2353 2308 1387 6774 6934 1869 4089 10298 3914 3486 2263 1398 581 3913 27 818 367 64399 5291 1029 5879 6608 323 5594 143686 50484 6198 7189 4609 5728 2475 83593 867 1499 8322 3551 3685 1019 2535 1870 1282 399694 3479 598 5467 6513 PMC9353186__F7 Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway 3565 383 920 PMC9354322__F3 Pleiotropic roles of cGAS–STING signaling in the tumor microenvironment 11201 338376 3661 4485 PMC9355329__F3 Copy Number Variation of Circulating Tumor DNA (ctDNA) Detected Using NIPT in Neoadjuvant Chemotherapy-Treated Ovarian Cancer Patients 472 3297 388 389 23440 5880 29 653689 283820 340393 PMC9356572__F2 Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion 55364 107966124 7098 7187 57506 3661 7454 3665 6773 PMC9358627__F4 Association of ABCC2 haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients 5243 1244 54577 54576 54575 7364 54600 3615 3614 8824 1576 1577 1558 PMC9358975__F1 Correlation Between MicroRNAs and Diabetic Retinopathy 4703 4851 8900 468 1537 118856 PMC9359488__F2 Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination 58191 7297 10379 6773 3665 3661 3458 7098 51284 1628 729230 4615 7099 729 735 10410 3123 PMC9364625__F5 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity 196 3939 51311 2475 2194 22937 50943 8205 948 PMC9367163__F7 Combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway 9776 4854 2475 64422 10533 PMC9367204__F1 Of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis 7113 59272 84876 6786 100170220 200576 3916 5266 PMC9367541__F1 Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma 5163 2475 940 2885 3702 3932 10892 387 84433 8915 6654 5335 2534 7409 920 998 7535 PMC9368002__F1 Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells 7422 6720 165679 347735 54361 1903 7474 2181 5997 5730 116285 80339 958 5255 6387 3627 5228 4987 9420 10062 4804 1601 4340 54898 688 2572 3791 2678 64388 2915 351 3485 PMC9369123__F4 PKC-MAPK Signalling Pathways in the Development of Hyperglycemia-Induced Cardiovascular Complications 7412 3383 581 847 PMC9369298__F3 diaPASEF Proteomics and Feature Selection for the Description of Sputum Proteome Profiles in a Cohort of Different Subtypes of Lung Cancer Patients and Controls 2152 2155 2159 2161 2147 2160 7450 2157 1361 2 5340 2271 718 1431 966 1378 717 1380 PMC9371342__F1 Summary of the major components of the extrinsic and intrinsic pathways of apoptosis induction following viral infection 468 7098 22926 7124 581 115004 3661 PMC9371512__F6 The Bushen Huoxue formula in the treatment of osteoarthritis based on network pharmacology-molecular targets 5979 10855 960 673 4322 7056 1514 3486 4321 1147 2353 5468 7421 4313 3725 7276 1509 952 5465 4353 3576 6714 5743 4318 54205 7124 154 4609 7010 596 7157 3627 836 5970 2064 3586 5328 3791 4314 6401 3320 6347 PMC9374094__F2 Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges 3620 196 5091 PMC9374593__F8 Working model that PFKFB3 inhibition plays an important role of deregulating cancer stemness, EMT and chemosensitivity in small cell lung cancer 5209 2147 4485 4771 9113 960 6657 9429 999 PMC9375325__F1 PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers 1386 64798 64223 2475 5728 7248 7249 6009 1000 4313 999 5163 2932 4193 581 PMC9375325__F2 PI3K/AKT pathway in squamous cell carcinoma with an especial focus on head and neck cancers 3691 4053 3918 55294 1000 2308 999 940 1944 5728 2932 55750 5170 572 581 27250 PMC9379405__F6 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways 79971 4040 4041 8549 59352 2932 5879 607 324 1499 1540 54894 84133 51701 10454 23118 4609 595 5467 2475 3725 PMC9379893__F3 Integration of mechanotransduction pathways and innate immune cell activation 9780 759 1906 59341 57591 6722 1843 3606 3569 7124 6347 PMC9386506__F6 Microsatellite DNA-derived oligodeoxynucleotide attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting the HMGB1-TLR4-NFKB signaling pathway 3146 3663 7189 51135 4615 7099 23118 257397 10454 3654 PMC9387421__F3 Zinc delays the progression of lung disease by affecting a variety of signaling pathways 581 572 3553 2475 PMC9392297__F2 Toll-like receptors and their role in neuropathic pain and migraine 51284 54106 23118 10454 51135 7189 4615 5970 10333 7097 114609 4118 7099 7187 3661 7098 81793 PMC9392712__F4 Targeting autophagy as a therapeutic strategy against pancreatic cancer 3099 3098 22934 6120 2805 4190 4118 4199 6510 2806 11113 2744 54407 84706 100653366 PMC9393259__F1 Underlying pathological mechanism of ferroptosis in the development of cardiovascular disease 2936 2879 23657 PMC9394413__F3 Normal and Pathological NRF2 Signalling in the Central Nervous System 9817 10072 79728 672 60468 571 2729 2730 2877 493869 847 2936 596 2512 3162 2495 1728 5226 2539 PMC9394511__F9 Schematic model illustrating the PI3K/AKT pathway associated with CCRL25/CCR9-induced malignant biological behavior in SACC 6370 10803 596 581 595 999 PMC9395317__F4 Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy 3082 1950 6714 387 6387 6347 2932 8205 2885 3586 324 1499 5163 5164 3606 10454 23118 4087 4088 4089 7852 4318 6774 999 1000 PMC9395634__F4 MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes 6866 25805 10247 114897 7124 6217 7157 4502 8490 51232 7849 2099 100302692 56892 148189 104472715 347689 149775 PMC9405053__F1 Celastrol: A Promising Agent Fighting against Cardiovascular Diseases 51083 7098 114548 3297 19 PMC9405349__F7 GLUT3 Promotes Epithelial–Mesenchymal Transition via TGFB/JNK/ATF2 Signaling Pathway in Colorectal Cancer Cells 1386 999 1000 6935 PMC9406168__F6 Integrative, In Silico and Comparative Analysis of Breast Cancer Secretome Highlights Invasive-Ductal-Carcinoma-Grade Progression Biomarkers 2200 3915 3914 3959 3912 3913 375790 3688 3486 1294 3918 4090 4086 4609 2002 4149 4089 6667 3339 1514 1515 4017 4200 5163 2475 1499 595 430 2353 6774 4052 6385 1956 7045 71 3949 7057 1605 2335 7422 3911 2817 255738 8324 PMC9407007__F2 Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease (NAFLD): A Concise Review 6347 3627 58191 54567 920 6387 7852 3569 3553 PMC9407616__F9 Transcriptome Analysis Identifies Key Metabolic Changes in the Brain of Takifugu rubripes in Response to Chronic Hypoxia 273 8612 3032 635 5136 23236 226 80150 8659 5210 5315 4852 3146 2026 966 127281 22885 PMC9409144__F1 Oxidised Low-Density Lipoprotein-Induced Platelet Hyperactivity—Receptors and Signalling Mechanisms 85451 10011 387 6850 2534 4067 948 51135 4615 3654 5139 PMC9412206__F1 Left ventricular noncompaction: a disorder with genotypic and phenotypic heterogeneity—a narrative review 3720 2280 3084 9510 4853 27302 2066 2064 57534 8650 9253 4878 2115 6910 9353 10371 79191 23493 57057 63976 7528 54617 1306 2057 5914 2056 PMC9412801__F2 Clinical Utility of the Sivelestat for the Treatment of ALI/ARDS: Moving on in the Controversy? 7096 7097 4615 7189 929 2002 7099 5163 PMC9420296__F2 Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells 545 472 1200 54386 25913 4613 7015 546 1616 7012 PMC9420733__F4 Signaling pathways in obesity: mechanisms and therapeutic interventions 4040 4041 9885 1499 118 6774 51523 147111 7350 6259 387 PMC9420733__F5 Signaling pathways in obesity: mechanisms and therapeutic interventions 2194 2167 652 7350 5443 4852 181 PMC9423707__F2 Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future 1956 26524 79188 6774 3485 572 1499 6935 999 PMC9424577__F6 An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products 7099 3146 83939 472 8737 11035 197259 317 324 PMC9428205__F7 Potential regulatory mechanism of inhibiting autophagy to enhance the cytotoxicity of FIIN-2 on A549 and A549/DDP cells 581 10818 2475 PMC9428582__F2 Targeting O-GlcNAcylation to overcome resistance to anti-cancer therapies 2091 8473 7037 2495 3162 2030 100170220 5238 1956 1191 PMC9433080__F1 Treating non-small cell lung cancer by targeting the PI3K signaling pathway 5728 572 842 4193 6010 5163 7248 2308 2309 7249 6009 5888 1111 PMC9433407__F9 Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response 5209 5226 2539 2147 8402 3417 3418 6576 2242 PMC9433414__F3 Interaction between the circadian clock and mTOR-related signaling transduction pathways 150094 8864 2885 7432 5187 3667 1977 7249 7248 51256 6009 64223 5728 5163 64798 PMC9433570__F9 Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism 3553 4803 57826 5796 55958 6372 26298 218 1116 7148 7123 6241 10112 11065 991 9133 7980 2921 891 PMC9433876__F2 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response 4485 3458 7097 7099 6696 2919 1435 383 9332 6387 PMC9436900__F2 PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities 197259 8737 11035 8772 8717 581 8408 9706 9776 PMC9436908__F2 Modulatory effect of high salt on immune cells and related diseases 7124 10725 114548 58484 6778 3662 2475 383 PMC9437549__F2 Microbial lectome versus host glycolipidome: How pathogens exploit glycosphingolipids to invade, dupe or kill 53947 9334 8869 2583 84002 6489 29906 10317 2524 2525 8705 6482 PMC9438316__F2 Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma 30968 3939 2597 3945 26227 2539 5163 378938 4751 PMC9452894__F3 Chemistry and efficacy benefits of polysaccharides from Atractylodes macrocephala Koidz 581 2932 1499 PMC9455009__F1 Programmed Necrosis in Colorectal Cancer 7124 8717 7186 8772 3002 3001 2879 PMC9457753__F2 Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use 7099 114609 4118 7189 23118 10454 929 3929 148022 3661 7187 4513 3665 8989 7442 59341 80036 114548 PMC9458733__F4 Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer’s disease (from the Nakayama Study) 51582 113451 4946 4947 51686 383 384 6723 6611 162417 5009 54498 435 1373 4942 PMC9461661__F3 Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer 142678 7726 80128 2879 9817 8452 9978 4193 2181 6737 6502 26267 116138 2182 10162 154214 23327 4057 11236 8924 8031 7417 7018 7419 4734 PMC9461661__F4 Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer 8314 7874 9100 9097 9958 29761 51377 23657 2879 8237 9817 8452 9978 57558 2182 10162 7018 7012 8031 PMC9462548__F1 The JNK Pathway in Bladder Cancer 6714 581 572 2475 9474 PMC9463442__F7 Regulation and role of RNAPII-generated nascent RNA to guide DNA end resection and DSB repair by HR 4361 672 246243 5893 29102 PMC9463773__F2 Diversification of PAR signaling through receptor crosstalk 771 6714 4512 1950 4513 6010 7099 7939 7046 4087 4088 3661 PMC9463785__F1 Weipiling decoction alleviates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric precancerous lesions via NFKB signalling pathway inhibition 2520 3135 2693 2936 6750 4524 5328 2152 1543 1244 2353 5111 1803 2767 7097 581 5447 4780 6347 1956 948 2922 4609 7316 3725 5970 1387 4353 7298 7150 5925 3630 367 847 7422 3952 3105 2033 627 2950 3643 1080 1991 5243 596 54205 3479 983 4922 2719 567 217 2194 1508 887 1576 6868 5743 7124 836 207 3569 7157 3091 6774 PMC9463785__F3 Weipiling decoction alleviates N-methyl-N-nitro-N′-nitrosoguanidine-induced gastric precancerous lesions via NFKB signalling pathway inhibition 2194 581 4353 2353 3458 7150 2936 2922 5594 7153 4313 5290 3383 4609 5728 3643 4790 6714 2767 596 5970 1387 10413 2520 847 6750 387 2919 1080 217 4314 1244 7048 1509 1277 3135 5468 6697 6347 7298 1017 4322 2944 367 6513 7097 3558 5243 1519 2100 2099 1543 7124 1026 983 948 887 3586 5879 3606 2033 2719 142 8544 5328 1576 3725 2152 6233 7852 1499 6648 4843 2693 1958 7157 3479 2475 23411 3952 1956 1571 1508 7422 4922 5467 2241 PMC9465182__F1 Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice 4099 8915 64170 10892 5346 PMC9465647__F1 Resveratrol on rheumatoid arthritis: From bench to bedside 2353 23411 9817 5970 8452 PMC9467317__F1 TNFR1 signal transduction pathway 7124 8717 7186 717 1540 331 8772 197259 PMC9470853__F7 Fatty acid export (FAX) proteins contribute to oil production in the green microalga Chlamydomonas reinhardtii 20 355 2195 PMC9471064__F1 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets 8717 7186 8772 545 581 983 2475 8737 11035 197259 2879 PMC9476726__F10 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 4615 3929 929 54472 7189 4049 23118 10454 PMC9476726__F2 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 7124 8772 7186 8717 54472 4615 51295 331 4513 PMC9476726__F5 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 2056 2057 3717 7297 6773 4513 2475 2885 PMC9476726__F7 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 4485 60485 9113 6010 4018 PMC9476775__F5 Brusatol: A potential anti-tumor quassinoid from Brucea javanica 2475 999 1000 8878 581 PMC9482771__F6 Target genes implicate in inflammation process potentially altered by miR-378 5608 5908 1845 2005 3304 8569 8649 55970 6197 2316 51719 1850 775 207 9965 27330 59283 64750 9706 10637 4763 23118 6196 6194 4838 656 6789 7042 673 7048 3479 7027 4609 5170 1875 2002 353500 9455 659 3398 23678 392255 100533105 9140 5747 472 2290 53358 27 901 3276 4690 2549 3084 867 5063 PMC9484955__F1 Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy 6262 581 114548 3606 PMC9487140__F1 Review of potential medical treatments for middle ear cholesteatoma 3146 1540 3570 695 3397 7099 4282 PMC9496100__F3 Ginsenoside and Its Therapeutic Potential for Cognitive Impairment 3480 3479 5925 2247 5728 5163 572 581 2932 2475 PMC9496369__F1 Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives 847 7412 3383 1956 PMC9496846__F4a Systematic Analysis of Genetic and Pathway Determinants of Eribulin Sensitivity across 100 Human Cancer Cell Lines from the Cancer Cell Line Encyclopedia (CCLE) 4149 9218 1080 2100 5111 408 8452 1950 2033 5606 6938 9126 203068 3858 1879 6850 867 351 3191 10664 4609 7531 7534 11260 1956 PMC9497173__F1 Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment 3099 3098 6120 22934 2673 4118 2805 4190 4199 6510 2806 11113 2744 2746 84706 54407 100653366 PMC9497187__F9 Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells 10715 204219 8560 29956 253782 123099 6610 55627 8877 125981 55331 56624 64781 2629 2720 PMC9498168__F6a MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway 84651 10060 4118 10143 167838 7074 3552 5137 22865 64240 23336 284254 3782 1830 55026 50804 5350 11045 125 9590 2353 143098 493 846 285704 5602 1837 367 2895 5999 253559 6422 339967 100507203 4057 389015 7957 157753 2752 10365 11034 639 142679 11040 2891 2899 55553 8013 121214 26508 9172 22873 51050 255928 144455 4810 23314 7652 121506 84467 440145 1515 23269 3559 8618 51804 1758 3817 84296 84696 63967 2842 27085 8767 705 5897 6334 6659 54443 4158 5933 57471 6657 149483 8788 PMC9499417__F1 IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy 6772 6774 3716 3718 2932 596 572 581 2475 PMC9500712__F8 Molecular Mechanisms of Cassia fistula against Epithelial Ovarian Cancer Using Network Pharmacology and Molecular Docking Approaches 5294 5132 2203 1636 2159 4353 5644 412 7124 3486 6790 213 7015 47 1230 2149 1586 4137 9833 7376 5241 983 4312 7153 7298 5243 5290 1017 768 3606 367 1499 3815 126669 7010 3643 5970 3320 5781 4314 4318 596 3791 2100 5743 4313 PMC9502833__F2 Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture 4040 4041 324 1499 7018 51592 PMC9503107__F8 Cleistocalyx nervosum var. paniala Berry Promotes Antioxidant Response and Suppresses Glutamate-Induced Cell Death via SIRT1/Nrf2 Survival Pathway in Hippocampal HT22 Neuronal Cells 1267 23411 847 2876 PMC9503909__F8 Fractionated Proton Irradiation Does Not Impair Hippocampal-Dependent Short-Term or Spatial Memory in Female Mice 537 527 535 9114 91663 10651 11160 55766 641371 9555 3014 1329 1340 3020 PMC9515456__F4 Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories 22926 7494 196513 55802 5073 23644 27161 10146 5494 83939 PMC9515494__F8 Systemic tryptophan homeostasis 350383 59272 340024 6564 6520 8140 23428 117247 2475 6565 9776 8408 7166 121278 3620 PMC9522619__F2 Properties of flavonoids in the treatment of bladder cancer (Review) 7124 355 8717 8772 581 2475 60673 22863 2879 55240 PMC9523377__F3 Multifunctionality of Calebin A in inflammation, chronic diseases and cancer 7124 7852 6774 PMC9523540__F3 Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction 581 2475 8408 23411 4899 7019 6648 57716 90550 PMC9526582__F13 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer 5105 948 693221 PMC9539803__F1 Frontline workers: Mediators of mucosal immunity in community acquired pneumonia and COVID-19 59272 7113 54209 1950 2920 2919 6347 6354 3569 3553 3576 3627 920 90865 3716 1636 PMC9540245__F6 Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis 3099 3091 3939 5230 7296 PMC9547753__F3 Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options 355 9140 3146 2879 79792 PMC9550190__F1 Conducive target range of breast cancer: Hypoxic tumor microenvironment 383 6387 3603 6774 5163 664 3939 1956 2475 140885 961 6347 6352 PMC9550700__F7 Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model 50943 3595 3459 100187761 50615 324 3606 7040 3586 8807 7097 3569 149233 6774 64127 30009 3552 6095 115209 283131 2625 11009 3553 59067 3458 8809 7054 6886 7124 PMC9553089__F2 Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study 3146 4597 3652 2224 6010 2339 5876 1352 9453 5229 920 5914 22937 10280 975 25939 PMC9553959__F2 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways 1869 4609 545 4193 84883 3486 5728 1021 1019 64065 899 914 637 64326 842 836 3479 2475 PMC9553959__F4 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways 821 3458 7124 811 1508 6892 1514 1520 920 PMC9556788__F7 Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs 720 712 735 5199 713 343413 608 388364 81788 122809 9966 30846 2664 4641 7514 1174 10483 8775 51028 64083 6730 2288 6836 708 722 55667 55605 5576 23120 6451 646627 9209 9026 11074 6737 9246 7336 27101 5720 6194 4141 6201 55699 23589 1974 23095 127833 1213 23200 91683 1356 100170220 718 727 717 10747 50808 27010 5834 2271 6390 47 8802 3418 5447 33 PMC9559307__F1 Biomarkers in the Management of Colorectal Liver Metastases 1950 572 581 5728 3479 5163 3480 2932 324 1499 PMC9561135__F10 Gut-lung axis: Gut microbiota changes associated with pulmonary fibrosis in mouse models induced by bleomycin 641 999 7124 581 7046 7048 4087 4088 1277 1281 PMC9562648__F2 Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities 581 54106 29110 115004 3661 7416 114548 3553 9447 PMC9563036__F3 Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health 407019 8826 5879 1003 PMC9563287__F1 Richter Syndrome: From Molecular Pathogenesis to Druggable Targets 4851 613 695 7157 5336 7514 PMC9563430__F9 PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression 3725 27148 51684 10125 6790 5591 472 3240 3516 2033 10411 1387 324 2177 5925 4683 8649 4035 1499 2353 4090 4086 10928 6885 23118 6714 998 1031 5933 4609 5747 2549 867 4193 7157 572 27113 56616 54205 836 637 10018 581 8837 8772 1616 356 PMC9563506__F9 PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages 255738 4282 999 1000 4318 942 3553 4283 383 9332 PMC9569554__F2 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair 54567 860 6662 8828 8829 117581 4318 4314 4312 4843 9507 4322 5743 PMC9569554__F5 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair 4040 4041 1499 9242 7124 650 4090 4086 PMC9569894__F8 Transcriptome Analysis Reveals the Complex Regulatory Pathway of Background Color in Juvenile Plectropomus leopardus Skin Color Variation 4157 50964 1499 4286 7306 1638 3667 PMC9570224__F5 Targeting Phospholipase D Pharmacologically Prevents Phagocytic Function Loss of Retinal Pigment Epithelium Cells Exposed to High Glucose Levels 5337 5091 5338 6120 PMC9571692__F1 New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects 8452 847 1728 PMC9572851__F9 Torularhodin Alleviates Hepatic Dyslipidemia and Inflammations in High-Fat Diet-Induced Obese Mice via PPARA Signaling Pathway 10133 11124 79792 581 8772 836 6093 355 2052 10413 328 2185 2950 6774 10580 3383 4282 3643 4035 51599 5244 7276 435 5105 337 336 3158 335 2169 2168 1374 1581 8647 11001 10455 4199 1632 2171 10998 38 123 10999 729359 622 PMC9573421__F5 Phytochemicals in Skeletal Muscle Health: Effects of Curcumin (from Curcuma longa Linn) and Sulforaphane (from Brassicaceae) on Muscle Function, Recovery and Therapy of Muscle Atrophy 8452 9978 9817 3553 PMC9577795__F4 Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis 4012 22849 27069 80303 3630 344 9926 3217 153768 362 3171 83605 5179 7857 222962 79027 51450 3635 10981 2353 142684 47 4884 268 100 4935 1907 5192 4804 28513 27075 79170 284293 9833 1136 10439 81794 9422 9263 10342 2873 128611 5641 972 4761 200634 9058 4140 54970 146691 2526 83706 317781 84662 23012 9420 6588 375061 654429 91522 79026 5106 57761 4135 4915 55655 2295 11010 894 400629 655 4885 6990 8269 55762 54760 5603 360 6598 3218 9363 338773 9853 23555 3880 6512 6837 7481 2002 8811 58528 2810 358 3856 54557 127435 3872 9625 64210 5645 388394 7547 357 2670 131578 432 5648 54659 6753 122553 63973 7737 7450 11091 5528 7343 4852 3780 8525 140576 1525 79930 27345 57165 2121 54860 23483 54854 6447 79734 PMC9578007__F1 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis 31 7494 6720 6347 79026 6513 3146 1869 7124 23411 2194 1956 9775 5468 7099 6647 5465 3605 3991 6517 9971 2247 9370 26291 3952 1374 3630 6369 3606 10891 PMC9578007__F3 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis 1029 197 7351 847 7099 7124 3630 6517 6647 5468 10891 10468 9370 1956 5465 PMC9578258__F2 Synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment 472 1017 983 993 54465 11073 545 7465 994 995 6741 142 1643 1642 7507 7515 79728 5888 672 10721 675 50485 PMC9578583__F3 Diagram representing the enzymes involved in the 11 steps of the glycolytic and methylglyoxal pathway and tricarboxylic cycle found in the rumen epithelium of sheep 3939 2821 226 2597 5230 2739 3029 197257 11315 1738 1737 8050 4199 1431 2271 1743 4967 PMC9581055__F10 Identification of Biomarkers Controlling Cell Fate In Blood Cell Development 2625 4613 4772 1028 2078 2697 1499 6667 1030 4088 3725 6886 2313 860 4286 10673 4091 581 6662 PMC9584359__F2 EBV-driven 1C pathway drives nucleotide and glutathione synthesis 26227 29968 5723 4522 94081 81034 6472 10797 25902 PMC9587781__F2 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease 966 7124 3603 728 PMC9588367__F3 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis 2159 3620 43 1559 1565 5473 3329 952 6097 9212 5591 3818 1557 5742 2153 2260 5291 3791 4358 3717 840 1269 1432 983 5327 142 5894 114548 6401 26986 3815 2475 2056 3569 120892 213 1956 6774 847 1890 2064 50484 427 1111 6850 2321 3586 5027 5290 3458 6347 5294 1019 55215 5293 240 2322 5599 5888 291 1017 834 5428 1991 1716 1576 29110 6790 PMC9588367__F5 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis 55215 56652 1716 5473 50484 4569 4566 5888 840 1557 4556 120892 4575 3815 5286 3791 847 952 2159 5294 1890 2056 3586 4513 213 5428 6401 6097 3458 1576 2153 2321 6347 2475 5291 6850 5293 6790 5027 3717 5290 2322 3569 27163 2064 3620 7535 1991 4541 1019 1017 6774 1956 1432 43 4514 1269 114548 4519 5327 1565 1559 PMC9588367__F8 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis 4358 56652 5473 983 6347 3586 55215 4566 4558 5286 3791 213 847 3815 1890 2056 4513 4575 2159 952 5428 1576 6401 6850 2475 6790 27163 3717 3569 3620 5027 43 2064 1956 1017 4514 4541 834 5327 5290 4519 240 1269 PMC9595130__F3 Ferroptosis and musculoskeletal diseases: “Iron Maiden” cell death may be a promising therapeutic target 2495 8031 8678 8314 23657 3309 2643 2937 2879 6520 467 23410 7163 5447 2181 2182 10162 PMC9598597__F3 Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties 929 7099 4615 7189 PMC9599057__F3 Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer 7124 8772 581 637 1021 1019 983 4193 5728 1017 207 PMC9600485__F1 TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems 8772 637 581 317 PMC9600888__F1 Iron Oxide Nanoparticles Combined with Static Magnetic Fields in Bone Remodeling 4041 1499 860 650 4090 4086 1540 4772 7189 54 1513 PMC9600942__F5 Tumor-Infiltrating Dendritic Cells: Decisive Roles in Cancer Immunosurveillance, Immunoediting, and Tumor T Cell Tolerance 8205 6347 1435 50943 3620 PMC9601130__F1 Novel Approaches in Non-Melanoma Skin Cancers—A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC) 6608 51684 374654 2737 2736 PMC9602726__F5 GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway 8940 55677 22836 56655 5337 55022 23054 8760 9462 51184 5298 1915 1969 22808 5432 6667 7277 2026 2697 7027 567 23369 7251 5290 1027 9337 4221 208 7994 64708 1471 204 29922 4351 5311 80184 55764 57728 PMC9603382__F1 Pathogenesis of Port-Wine Stains: Directions for Future Therapies 2776 5331 285 5163 2475 7422 PMC9606688__F2 mTORC1 beyond anabolic metabolism: Regulation of cell death 5728 83667 23657 8408 9817 2729 2730 2937 26524 9113 4771 999 PMC9606818__F2 Effect of narcotics on ferroptosis-related molecular mechanisms and signalling pathways 2182 10162 55240 8031 23657 6520 2879 4025 2744 2937 2936 4193 5465 PMC9608511__F4 Current insights into the regulation of programmed cell death by TP53 mutation in cancer 6303 100 2879 23657 6520 2936 PMC9608867__F2 Immune regulation and emerging roles of noncoding RNAs in Mycobacterium tuberculosis infection 406907 7189 6774 6772 9306 6093 4615 406888 9532 PMC9609565__F7 Morinda officinalis Polysaccharides Ameliorates Bone Growth by Attenuating Oxidative Stress and Regulating the Gut Microbiota in Thiram-Induced Tibial Dyschondroplasia Chickens 2876 860 650 PMC9613808__F2 Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics 7808 59272 57506 7187 9641 3661 7113 3665 7098 51135 7189 7097 10333 7099 695 54106 114548 3454 51284 PMC9616754__F1 Amyloid B in the pathological mechanism of GNE myopathy 7415 7494 468 351 10020 8408 3480 5728 581 PMC9617479__F3 Metabolic features of innate lymphoid cells 383 8694 2475 8011 355 PMC9956228__F2 New Insights into the Genetics and Epigenetics of Aging Plasticity 9575 4199 5927 4200 10765 55870 7994 56978 63976 23411 2145 22933 2146 51548 3065 3066 7468 10873 PMC9999652__F3 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 3691 4601 4609 665 2548 6472 3418 6510 47 PMC10030587__F2 Key events in cancer: Dysregulation of SREBPs 7124 2475 3417 2232 PMC10031116__F6 Extracellular matrix stiffness—The central cue for skin fibrosis 7049 4091 4092 4088 7189 9618 998 4087 4089 387 PMC10033548__F7 SFRP1 induces a stem cell phenotype in prostate cancer cells 6422 1499 324 79923 PMC10036758__F1 The complosome in health and disease 716 10747 718 717 2271 721 4179 1380 727 729 730 7448 PMC10037992__F4 Fasting: From Physiology to Pathology 2475 3651 4760 5081 PMC10040775__F5 Low-protein maternal diet during gestation affects the expression of key pancreatic Beta-cell genes and the methylation status of the regulatory region of the MafA gene in the offspring of Wistar rats 3725 467 5468 847 6513 2033 3630 2247 PMC10041518__F4 Supraphysiological GTP abundance promotes metastasis through the activation of RHO-family GTPases 3615 3614 2766 6010 998 8833 PMC10041595__F5 NRF1 Regulates the Epithelial Mesenchymal Transition of Breast Cancer by Modulating ROS Homeostasis 6657 999 1000 7082 7431 PMC1069621__F5 Two models for coupling of circadian and cell cycles 7465 545 84126 8914 1408 PMC108819__F8 Signalling pathways for EGF activation of c-jun 1950 2885 466 4209 PMC1133850__F10 Vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication 2002 6722 466 1958 PMC1174965__F4 Regulation of lipopolysaccharide (LPS) signaling by suppressor of cytokine signaling 1 (SOCS1) 3458 8651 4615 3661 7189 6772 PMC1176468__F9 Crosstalk model of ATF3 and c-myc in serum induction 5900 6714 1386 467 PMC1183194__F4 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin 7124 841 1445 3315 836 6774 317 1537 6772 5894 596 572 PMC1183194__F5 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin 1537 317 3002 842 837 840 329 836 834 835 839 1677 1676 351 4000 4001 PMC1183194__F6 Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin 11124 8772 1610 6885 6416 3725 839 397 367 1676 5925 4001 PMC1183479__F8 Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) 7249 7248 2475 1977 PMC1235815__F7 Possible ATM pathways contributing to polyomavirus replication (see Discussion) 472 4193 717 672 993 995 1017 PMC1236692__F3 Caspase signaling and its modulation 637 331 2620 PMC125566__F7 Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 474168 324 1499 26959 PMC1312313__F8 NO• regulation of the cell cycle 991 994 1017 983 1021 1019 990 1869 999 PMC1326326__F3 Proposed regulation of Cdc25A at the G1 and intra-S-phase checkpoints 472 545 993 1017 PMC139100__F8 Gelsolin-induced epithelial cell invasion is dependent on Ras–Rac signaling 6654 5879 8394 382 5338 5337 PMC1395315__F5 Elevated Homocysteine is associated with atherosclerosis 4023 3156 4318 1636 948 PMC1397816__F1 Inhibition of canonical Wnt signalling pathway in the absence of Wnt signals 4040 4041 324 1499 PMC1397816__F2 Activation of canonical Wnt signalling pathway in the presence of Wnt signals 4040 4041 324 1499 PMC1410746__F3 Genmapp view of the epidermal growth factor (EGF) signaling pathway 1950 3265 2064 1956 4893 2885 50964 4155 4133 2002 PMC1421301__F1 Interferon Regulatory Factor Expression in Human Breast Cancer 6772 3717 6890 4261 3660 PMC1440308__F7 Alternative Th network 920 3702 3566 7189 6778 2625 1386 6775 PMC1440856__F1 Omega-6 and -3 fatty acids & Prostate Cancer 2717 246 717 4513 247 PMC1447421__F10 Hypothetical model describing the roles of Rad18 and PolK in the BPDE-induced S-phase checkpoint 472 545 56852 5111 51426 PMC1475580__F1 Sequence of events in ATM→ ATR dependent signaling of DSBs in S/G2 cells 472 84126 545 PMC1479345__F6 Pathway analysis 948 816 341 7069 9253 351 2261 6774 212 3170 3171 3265 7781 652 56033 PMC1501125__F1 WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability 999 1499 2932 7157 5728 324 6925 PMC1502396__F1 The interaction between the AR and the ErbB/MAPK pathway 126669 367 2885 3725 2064 2065 572 2932 4193 1499 PMC1508148__F1 Pathway diagram of genes tested for association 1594 120227 1591 2638 7421 6256 3593 3594 3566 3586 6696 154 PMC151358__F5 JNK-dependent apoptosis signaling pathway 412 10395 90427 581 2021 27429 PMC153613__F4 Highlights of key changes in cell cycle, differentiation, and metabolism-related transcripts 604 894 1019 1845 6197 5601 4775 PMC1559676__F1 The unfolded protein response 1998 468 22926 7494 PMC1560089__F7 Proposed LITAF signaling pathway 4615 9516 7097 7099 PMC1601946__F1 E3 ubiquitin ligases regulating the TGFB signaling pathway 57154 64750 11059 83737 4089 324 PMC1664647__F1 Schematic representation of the Fas pathway used in the mechanistic model 355 841 836 331 839 PMC1682009__F1 Activation of the Akt pathway through binding of a ligand to a receptor, tyrosine kinase 5163 7249 6009 2475 1977 7248 PMC1761701__F10 Proposed model of lacritin mitogenic signaling pathway lacritin signaling suggested by data outlined in the text 6382 90070 4018 2475 6786 PMC1764624__F1 Synthesis and breakdown of proteins by amino acids 3667 2475 1977 PMC1768457__F1 CD14/toll-like receptor 4 (TLR4) intracellular signalling complex 7099 3929 929 2821 4615 7189 PMC1774275__F2 Intrinsic, or mitochondrial, pathway (after Danial and Korsmeyer) 572 581 637 56616 PMC1779657__F2 Recent observations on the regulation of fetal metabolism by glucose 207 208 7249 7248 6009 1977 PMC1782267__F2 TGF–TAK1 pathway 1386 4088 4089 4087 PMC1782589__F2 Signalling cascades of the LPS pathway and reported sites of IL-10 intervention 929 4067 5894 2932 9261 PMC1817809__F1 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues 181 95 2475 PMC1817809__F2 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance 1270 2475 95 PMC1828403__F1 Representation of TLR4-signaling through the MyD88-dependent and MyD88-independent pathways 7099 29110 7189 6773 10379 3661 7297 3455 3454 3716 4615 3654 PMC1838573__F1 Mitochondrial pathway through Bcl-2 family members 7124 3603 8772 7186 8717 7185 637 581 572 PMC1851974__F2 Regulation of cyclin D1 degradation 595 26259 1021 1019 7018 9149 2932 PMC1852210__F1 Diagram of folate and one-carbon metabolism in mammalian organisms 8836 2356 6573 6947 6948 4522 2618 6470 10588 1719 10797 7298 4548 4552 275 6472 191 4524 875 1491 PMC1852551__F4 Multiple estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid are implicated in estrogen-dependent growth of human uterine fibroids 301 4512 4513 1382 216 8854 3164 PMC1854955__F7 Schematic depiction of the molecular mechanism for the progression from HPS to chronic active disease or T-cell lymphoma in EBV-infected T cells 7188 7186 8717 8772 PMC1856765__F3 Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications 355 8772 637 581 PMC1857308__F9 The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones 5376 2475 10533 PMC1877091__F15 PDCD10/MST4 signaling pathway and CCM protein function 83605 11235 2002 PMC1894940__F5 Inhibition of COX-2 modulates multiple functional pathways during acute inflammation and pain 6648 242 247 59344 9021 3569 3248 PMC1899901__F6 A schematic model depicting the role of Artemis in the cellular response to IR 472 5347 983 7465 PMC1899931__F8 Theoretical model depicting potential interactions in the intra-S checkpoint signaling pathway 11073 545 84126 8914 54962 PMC1899986__F8 A model for cyclin E degradation regulated by two E3 ligases 1017 9978 8454 6500 8452 997 PMC1913583__F1 The methionine and folic acid cycles and the metabolic pathway of arsenic 9446 57412 4524 PMC1924866__F6 Striped view of multiple data types 3269 148 147 3274 150 151 152 153 154 155 2203 8694 3156 3949 949 4035 3990 4023 348 344 1071 341 324 5445 5446 PMC1933372__F3 RAN regulation pathway constituents exhibiting abundance changes, with a figure adapted from the GeneGo MetaCore database 7341 5905 5901 5902 5903 23440 8498 1104 PMC1936363__F1 Epidermal growth factor receptor pathway 5728 5163 5164 2932 2475 572 595 PMC1951772__F8 PI3K activation by eIF2A kinases 5163 2475 83939 253260 1977 PMC1959234__F1 Schematic model for the "error-free" BRCA double strand break repair pathway Brief overview of components within the BRCA pathway used here as a working model that was tested here 4361 10111 11200 472 672 675 PMC1974879__F1 Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src 5328 6714 10468 7035 7043 7045 1734 2273 79026 240 PMC1978064__F4 MiR-103/107 and PANKs may constitute coordinated transcription units with synergistic cellular effects concerning cellular acetyl-CoA levels and other metabolic pathway elements 4040 84918 2180 47 79646 51 80864 2194 23761 55066 5166 27165 PMC199174__F9 Models for the function of Ser307 phosphorylation 3479 3553 2885 PMC1994616__F1 New molecularly targeted therapies for lung cancer 1950 1956 3265 673 5163 5728 PMC2040891__F5 UVB acts at both the switch and the switched pathway to trigger UV-induced apoptosis 581 4193 1869 PMC2064799__F9 New calpain-dependent switch that controls cell spreading and retraction 6714 387 6010 998 PMC2077852__F3 Dmp1 links the Rb and p53 pathways 1019 595 4609 648 6909 6926 1758 3726 4193 PMC2094129__F2 Respective balance between Gi- and Gs-dependent signalling pathways and their roles in the modification of FcARI-mediated mast cell degranulation 4018 695 4067 6850 2534 PMC2096753__F1 Summary of purinergic pathways involved in microglial response 4803 5228 3553 5340 PMC2100342__F3 Activation of NFKB via the classical and the alternative pathway 4055 5970 5966 5971 7412 PMC2136409__F7 Genetic and epigenetic mechanisms of gene regulation during lens development 2246 2247 2253 2885 2549 4094 PMC2147675__F1 Antimalarial therapy prevents Myc-induced lymphoma 4609 2597 9140 664 PMC2150790__F9 The signaling pathways activated by N 3383 960 2064 6714 2885 6010 998 PMC2171731__F9 Invadopodium formation 1950 998 4690 PMC2173691__F7 Mechanisms of E-cadherin regulation in sparse and dense cultures of colon cancer cells 2064 1499 790 999 PMC2193446__F7 The hypothesized biochemical pathway responsible for the hyperproliferative phenotype of Nf1 +/− mast cells in response to SCF 5266 5880 5058 PMC2211634__F3 Models for the dual roles of KLF4 and KLF5 in tumor suppression and oncogenesis 9314 581 688 PMC2214701__F3 Building bone to reverse osteoporosis and repair fractures 6422 22943 4040 4041 324 2932 1499 6932 PMC2219551__F7 Signaling Pathway Involved in Neutrophil Elastase–Stimulated MUC1 Transcription 7039 1956 53905 6667 4586 PMC2247392__F2 Growth factors trigger local and long distance signalling 5595 8314 4803 1956 PMC2254585__F5 In silico knockout of PLCG1 in the HGF stimulated signalling network 6714 2885 6654 5728 5163 6774 1386 PMC2262896__F6 Interferon signaling 3716 6773 6772 10379 3434 8519 3659 5696 PMC2268054__F1 Role of glycoprotein 130 (gp130) downstream signalling in the heart 5008 3589 3976 3716 2549 2885 6772 6774 PMC2268064__F3 Regulation of the transcriptional co-regulator Beta-catenin 324 1499 51176 PMC2268956__F3 The major pathways leading to apoptosis 581 637 2021 27429 317 2597 PMC2268988__F3 Life and death decisions by the E2F transcription factors 11073 4193 23411 572 581 317 PMC2277413__F4 Gene Network A 1908 5867 5728 10682 1316 10370 4605 7089 6790 8819 9611 6601 23450 10155 PMC2277413__F5 Gene Network B 3872 1152 10947 7071 1030 6667 1316 3397 3054 3065 5925 5077 8804 55814 PMC2287285__F7 Comparison models summarizing how eIF4E is not only downstream of the PI3K–AKT pathway (left) but can modulate this PI3K–Akt axis through NBS1 (right) 5371 1977 890 891 595 898 4193 PMC23119__F3 Roles of INH-induced genes in the context of a proposed pathway for mycolic acid biosynthesis 1431 3623 1215 PMC2358943__F1 Metabolism of PtdIns(4,5)P2 by PLCG and PI3K 5728 5266 5163 7006 100124696 7249 7248 8915 2475 10892 PMC2383880__F1 Manual layout of Type II interferon signalling (IFNG) taken from the integrated pathway diagram (Figure 2) 3458 2619 3606 5580 PMC2391069__F1 Overindulgence and metabolic syndrome: is FoxO1 a missing link? 8694 84649 7038 5163 5164 2308 338 PMC2396493__F1 P53 on the IGF-1 signaling pathway 3479 3486 5728 2475 253260 5163 207 PMC239898__F6 Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer 2798 2492 2002 PMC2409614__F3 Development of tamoxifen (TAM)-resistant breast cancer and the changing role of oestradiol (E2) in the life and death of ER-positive cancer cells 1956 8205 355 8772 PMC2423292__F6 Musashi1 signaling in mammary progenitor cell proliferation 8650 27122 1499 3280 595 894 4440 PMC2423434__F5 Dynamically asserted instances of interactions 84301 414301 1576 324 PMC2427358__F8 Summary of GRTH impact in apoptotic pathways in germ cells 7186 8717 8772 637 572 PMC2438299__F6 Regulation of G1/S transition by the Cdh1/APC-Skp2-p27 cascade in colon cancer Cdh1/APC is critical in regulating Skp2-p27-cyclin E/CDK2 axis, resulting in averting abnormal entry of S phase 6502 1017 983 PMC2440410__F3 Regulation of post-cushion valve maturation to thin fibrous leaflets also includes EGF receptor signalling in addition to differential signalling of the pathways in c 4827 4091 4089 4087 4088 4086 4090 2066 2064 2065 1956 1950 650 652 1839 PMC2441985__F3 The regulation of the insulin signaling pathway by miRNA cluster mmu–mir-183–96–182 6464 2885 3667 5921 PMC2442829__F1 Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations 5728 5266 5163 7249 6009 2475 PMC2455793__F1 Interaction between two known Egr1 target genes, PTEN and fibronectin achieves a delicate balance between attachment and apoptosis of detached cells (anoikis) 1499 355 572 5728 1958 PMC2469272__F2 LPS signaling [modified from O’Neill and Bowie () with permission] 3661 3665 4615 4118 7187 7189 7099 929 PMC2474812__F1 Classical and back-door pathways of androgen biosynthesis 1583 412 3293 1586 8644 3294 1588 6715 1646 1645 7366 9420 7367 PMC2474943__F7 Points of action of flavonoids within PI3K/Akt signalling pathway 5164 5163 572 2475 PMC2474948__F1 Integration of the TGFB1 apoptotic signal by the lipid oxidation end-product 4-hydroxynonenal 7040 4092 4089 1386 PMC2491640__F5 Regulatory network of important genes involved in EBV-dependent NPC 2014 928 3718 5757 1647 3726 1956 6667 7086 6774 2353 1026 8564 1017 4318 5089 3205 7913 1045 4211 3615 1616 5723 4217 PMC2491722__F6 Gdnf signaling pathways within the mammalian spermatogonial stem cell niche 2668 2674 5979 2885 466 1017 PMC2492871__F4 Networks top-ranked by Ingenuity Pathway analysis after knockdown of TP53 (A) and LSR1+TP53 (B) 6690 664 7127 6275 50484 PMC2515553__F1 Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective 857 859 5728 26136 3716 4015 3932 4193 6714 6774 6772 6776 2932 PMC2518073__F8 Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer 5163 3667 5894 7249 7248 6009 PMC2527618__F4 Graphic illustrating the roles of 8 genes implicated in the present study in lithium-sensitive signaling pathways 64359 160851 2932 1499 83439 PMC2530034__F1 Transcriptional regulation and the pathway of RNA polymerase II transcription 1025 27343 11201 1283 1022 PMC2536868__F7 Pathways for major lipid metabolism 47 65985 50814 10654 4047 2224 6713 5091 1384 3992 9415 355 1636 57678 56894 8694 PMC2537559__F3 Glycolysis pathway 2023 2027 2026 5223 1431 5224 3939 3945 3948 PMC2537559__F4 Alterations in extraceullular matrix and secreted proteins associated with metastatic cancer 7078 7077 4319 5327 4312 5340 5328 3479 3481 5270 4325 960 1956 1950 5329 PMC2553712__F1 Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP 7124 331 8772 317 PMC2556568__F2 Molecular processes that handle — and mishandle — dietary lipids 39 84649 29881 7038 64241 64240 338 19 5091 339 51128 PMC2559887__F2 Ingenuity pathway analysis on AP-1 related gene network 3385 23268 55288 4282 85451 3817 10020 3569 354 3875 25803 3727 1350 50650 4170 6648 3398 7832 1351 10611 PMC2561962__F1 Ischemia induces cell death by several distinct pathways, and Hsp70 reduces all of these 355 581 317 842 PMC2563957__F1 Phospholipase A2 (PLA2) catalyzes phosphatidylcholine into AA in response to agonist stimulation of a G-protein–coupled cell surface receptor 4513 4512 717 PMC2575530__F2 Insulin-like growth factor-I signaling pathway involved in breast cancer 3479 3667 6654 2885 5728 2475 572 2932 PMC2575825__F4 Glutathionine (GSH) redox network 124975 2678 2687 1080 10539 51022 84264 5730 9536 5947 3265 1956 PMC2575845__F1 RLR signaling pathway and its negative regulatory molecules 54941 7706 9636 1540 7189 8772 79671 7187 29110 3661 PMC2577715__F15 Notch, Wnt, and SHH signaling pathways 6469 6608 1499 324 2736 2737 2735 PMC2582196__F2 Classic renin-angiotensin-aldosterone system (RAAS) pathway and angiotensin II (Ang II)/insulin signaling in the vascular smooth muscle cell 1636 27035 3479 3667 PMC2584013__F25 ER stress and ROS in NAFLD/NASH 22926 468 6957 7186 581 PMC2593077__F2 Hepatitis C and Innate Immunity – Recent Advances 7098 51311 51284 7189 51135 7187 3654 29110 3661 3665 929 PMC2594010__F2 Regulation of metastasis in colorectal adenocarcinoma: A collision between development and tumor biology 7471 999 1499 2932 324 4609 595 PMC2597184__F2 Nuclear Factor-kappa B Signaling in Skeletal Muscle Atrophy 7124 4055 958 5970 5971 PMC2597811__F1 Molecular Genetics of Colorectal Cancer: An Overview 1499 4089 324 387569 4436 4292 5395 PMC2597859__F1 Role of Programmed Cell Death in the Immunopathogenesis of Sepsis 355 8772 637 8717 4170 572 581 PMC2603135__F5 Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data 9328 6241 8522 3065 8027 9622 29945 92140 7728 54541 10911 1312 2618 9015 8570 PMC2603471__F1 Ageing, oxidative stress and cancer: paradigms in parallax 3934 6649 9536 3488 3872 8743 7124 5178 7040 5744 4318 596 8714 10563 7852 4036 51083 1601 5350 374 6876 3371 3918 PMC2605486__F3 Progressive changes in progenitor cells during motor neuron development 6656 6657 6658 6469 5080 10215 11166 3670 64843 282552 9580 6662 30812 6663 PMC2605486__F4 Olig2 and the transcription factor network controlling motor neuron differentiation 79191 3670 64843 282552 10215 6656 6657 6658 11166 PMC2612524__F7 A potential model for contributions of F-BAR-containing adaptor proteins and PTKs in regulating FcɛRI signaling during internalization 2241 2242 6850 4067 PMC2613484__F3 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways 4055 5971 7412 PMC2628394__F16 Biological network representing the bipolar disorder p-value ranking 9589 2690 4852 466 1386 468 3726 3727 972 3651 1390 3115 3796 PMC2631033__F1 Tumor necrosis factor and cancer, buddies or foes? 7124 8717 637 842 836 7186 8772 PMC2633398__F9 An epistatic pathway and genetic model for replication slowing in fission yeast 11144 1040 80198 119392 375757 5888 PMC2634987__F1 The GEP100-Arf6 pathway to invasion 1950 1956 382 PMC2640319__F1 Insulin and amino acid signaling pathway leading to the stimulation of translation initiation 3667 5163 7248 7249 2475 5728 6194 1977 PMC2640456__F1a Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes 51247 10988 2935 1982 1973 4744 1977 5594 4736 1654 3320 3146 7857 8496 3312 3837 2923 6143 3301 PMC2642591__F1 Retinoic acid dependent regulation of immune responses by dendritic cells and macrophages 127 128 324 216 10803 50943 PMC2649302__F3 Conversations between Wnt/Beta-catenin and MAPK signaling pathways 4040 387 5879 998 2932 1499 324 5894 PMC2649968__F4 Participation of DNA repair in the response to 5-fluorouracil 4436 2956 23583 4292 5395 545 PMC2651172__F7 Possible site for alcohol-induced inhibition of muscle protein synthesis 7249 7248 5163 6009 2475 1977 PMC2651433__F4 The Importance of NAD in Multiple Sclerosis 3458 952 8505 23410 23408 22933 23411 51548 23409 51547 54956 143 79668 83666 56965 10039 10038 57097 84875 54625 165631 142 64761 7226 PMC2652403__F1 Signalling through the phosphatidylinositol 3-kinase (PI3K) affects cell growth, apoptosis and cell cycle regulation 5728 7248 7249 6009 4193 1499 572 2475 PMC2652645__F1a Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning 929 7099 4118 4615 51135 6101 3654 7189 7124 PMC2652867__F1 PML regulon model is used to explain the effects of the PML protein and PML nuclear bodies on survival signaling as described in the text 5371 1977 2932 6502 4193 2475 595 898 PMC2655244__F8 Proposed model for the signaling pathway of Cao-induced keratinocyte differentiation 8394 1499 999 PMC2657945__F2 Regulation of the mTORC1 pathway by two distinct small GTPases 7248 7249 6009 PMC2661789__F1 In endothelial cells, after activation, VEGFR2 is able to stimulate the AKT/mTOR signalling pathway through PI3K 7422 5163 5164 6009 5728 1999 PMC2662567__F2 Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders 5340 5054 3082 5329 960 2475 6009 4763 PMC2662567__F3 Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders 5329 5054 5728 4763 6009 2475 PMC2662580__F1 Wnt therapy for bone loss: golden goose or Trojan horse? 11197 7471 324 1499 595 PMC2663399__F2 DNA Damage Tolerance: When It’s OK to Make Mistakes 5111 5064 56852 PMC2667705__F7 Regulation of hepatic HNF4A expression by insulin: involvement of SREBPs and proposed liver impairments 471 355 3949 3156 PMC2667750__F8 Proposed pathway for polyoxin biosynthesis 5429 27343 11201 51426 4810 5426 5428 27434 PMC2667897__F1 TGFB superfamily signaling: notes from the desert 1950 6714 2885 57154 8021 6497 5494 2735 2736 PMC2667983__F4 Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia 57103 9997 3976 4193 PMC2668232__F5 Principles in TLR signaling 7099 7187 4615 51135 3656 3654 10010 7189 23118 257397 29110 3661 4118 PMC2670521__F9 New Microbicidal Functions of Tracheal Glands: Defective Anti-Infectious Response to Pseudomonas aeruginosa in Cystic Fibrosis 29881 5580 6439 5961 6667 6609 6670 56624 598 5175 5581 8877 56848 6714 4067 26750 3932 4892 7186 2273 2274 2275 22938 1500 95 PMC2671642__F5 Comprehensive genomic characterization defines human glioblastoma genes and core pathways 1956 2064 5156 4763 5728 1029 1030 1031 1019 894 1021 4193 4194 5925 PMC2673422__F6 Hypoxia-invoked response of the glycolysis gene network 2821 3099 2645 2203 8789 5211 5213 5214 5209 226 229 230 7167 2597 97 98 5230 5232 5224 5223 2023 2026 5313 PMC2675653__F1 CART analysis of NER pathway and esophageal cancer risk 7507 2074 2067 PMC2678599__F7 Filia's role in ensuring euploidy of early cleavage embryos 387 5347 6790 PMC2679989__F1 Function of Nod-like Receptors in Microbial Recognition and Host Defense 64127 64170 257397 23118 717 3725 PMC2681001__F1 Biosynthetic Pathway of Coenzyme Q10 23590 57107 27235 51805 65260 493753 51004 93058 57017 80219 PMC2683723__F6 Insulin–EGF signal integration 1956 6714 2549 8544 PMC2686679__F12 Signaling pathway leading to Egr-1 biosynthesis in thrombin or carbachol-stimulated 39M1-81 cells 1950 5978 6722 2002 1958 PMC2688381__F4 Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia 9415 31 134429 55902 10682 230 PMC2688657__F1 Antigrowth signaling pathway and cluster around SMAD proteins 7046 7048 4193 4088 4087 4089 1017 1021 1019 4609 4093 29984 3172 10914 9863 10992 2192 5717 10457 PMC2688657__F3 Apoptosis pathway 842 839 596 840 836 572 637 841 8772 5728 581 8717 355 472 3875 PMC2694580__F2 Biological actions of isoprenoids 650 387 5879 998 PMC2696318__F4 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE 2885 545 472 6714 4193 581 572 1839 PMC2697824__F3 Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: A review 472 545 1956 993 5888 PMC2698645__F1 Simplified schematic representation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway driven by muscle contraction, insulin, essential amino acids (leucine), and/or energy 7248 7249 6009 5066 8491 29904 6194 1938 PMC2699281__F2 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease 581 4193 4194 PMC270001__F2 Chemoresistance in Human Ovarian Cancer Cells 1021 1019 4193 581 4937 331 355 PMC2702150__F3 FIBROTIC DISEASE AND THE TH1/TH2 PARADIGM 920 4318 5340 7939 948 3597 7054 4942 4843 PMC2703816__F3 Identification of neuronal target genes for CCAAT/Enhancer Binding Proteins 7314 672 23048 79629 1956 4436 998 961 2692 2917 1050 PMC2704234__F3 Immune activation induced by Beta-glucans 7097 10333 7099 6850 4615 7189 64170 PMC2704251__F1 Porphyromonas gingivalis-Host Interactions: Open War or Intelligent Guerilla Tactics? 7097 7096 7852 114609 4615 PMC2704571__F2 Diagrammatic representation of hormone therapy-induced changes in gene expression in the dorsal raphe block 140805 8564 2263 1950 4803 627 5607 7316 51283 7049 7046 8717 8772 1616 355 6416 27242 7124 27250 7130 11124 4090 317 PMC2708714__F2 Direct targets of WT1 identified in the Wnt signaling pathway 51339 1499 324 6907 51701 PMC2712099__F2 The aryl hydrocarbon receptor (AHR) signalling pathway 57491 196 405 PMC2715000__F8 Summary of caspase 2-mediated signaling cascades in heat-induced germ cell apoptosis 1432 4843 581 596 2669 PMC2715501__F1 Study background 367 1583 3293 3294 1584 1585 3292 3291 PMC2716493__F1 Two main pathways involved in apoptosis regulation 355 572 637 PMC2717887__F2 Clusterin as a critical signaling node 3952 64386 2547 7448 335 5444 4605 1499 3727 7048 3725 1191 8425 PMC2720262__F1 Summary of consequences on signal transduction and brain architecture of conditional Pten or Pdk1 deletion, alone or in combination 2475 4280 5728 5163 6009 7249 7248 2932 1977 6247 2931 PMC2720726__F1 IFNB activated pathway 3454 3455 6773 6772 10379 3659 6890 PMC2724029__F4 Signaling networks upregulated in migrating neuroblasts 27345 8936 10411 1462 9419 8925 PMC2726781__F1 Retromer sorting pathway is made up of a coat complex that binds and transports transmembrane receptors between the endosome and the trans-Golgi network (TGN) 351 5284 4074 55737 51699 PMC2727431__F1 Various states of pluripotency 6657 9314 3976 999 PMC2727910__F1 Map of arachidonic acid (AA) cascade 4512 4049 4050 5226 PMC2729380__F6 Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes 4088 1053 638 1977 1958 6497 5371 6672 6892 1831 5829 7345 PMC2729995__F1 Apoptosis and the main anti-apoptotic molecules: Binding of death receptors (Fas, TNF-R, TRAIL-R) to their ligands (Fas-L, TNF, TRAIL) initiates the extrinsic apoptotic pathway 7124 637 8772 8717 596 PMC2734563__F2 Possible mechanisms of UbcH7 regulation of Chk1 levels sand S phase 5728 4176 580 672 PMC2737093__F6 Schematic view of PPARG activation in VSMCs 1958 4087 4088 10893 PMC2739389__F2 Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape 3082 3479 3481 3480 5728 5163 673 2475 595 4286 5595 5594 1021 1019 2308 2002 PMC2739756__F4 FXR-independent and bile acid-activated cell signaling pathways in regulation of CYP7A1 transcription 7099 7040 3553 3082 1956 7421 1581 1810 PMC2743144__F1 mTORC1 signaling governs hematopoietic stem cell quiescence 5728 6009 55294 5371 PMC2745384__F6 RCAN1 mediated regulation of cell proliferation and apoptosis: Schematic shows that GC-dependent GR activation and subsequent MAP kinase-dependent phosphorylation enables GR binding to GRE sequences on target genes 2638 11123 10231 1827 PMC2746747__F1 Molecular ablation of TGFB signaling pathways by tyrosine kinase inhibition: The coming of a promising new era in the treatment of tissue fibrosis 7046 4088 4086 4089 4087 5062 PMC2747008__F12 Induction of IFNB and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7 7297 3716 7189 7187 3661 6773 6772 29110 3725 1386 3454 3455 PMC2749862__F5 Most prominently affected gene network in response to DEX in TM 86 cells 4820 80829 9128 10250 9774 25852 PMC2749862__F6 Most prominently affected gene network in response to FA in TM 93 cells 22998 8544 4496 83461 57730 28978 9184 55148 4494 4493 4501 11004 11339 PMC2752022__F2 FoxO factors in endothelial cells 7412 5087 595 PMC2752373__F1 Selected transformation pathways of tamoxifen and the main CYP enzymes involved 1565 1559 1555 1557 8205 PMC2752832__F7 Scheme for up-regulation of the PAI-1 gene by EGF in glioblastoma 1950 1956 64866 8877 6714 1386 PMC2757135__F1 Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states 1583 706 6770 4864 10577 PMC2758290__F1 The SIAE (sialic acid acetylesterase)-Siglec pathway for inhibitory signaling 613 933 4067 54414 PMC2758293__F2 An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective 2932 3611 92359 64398 10207 6714 1499 2241 1000 PMC2761106__F8 BMP7 signaling in the NZ 655 4090 4086 3397 1386 PMC2762943__F3 P53 pathway 1869 4609 4193 581 355 595 PMC2766677__F7 Proposed scheme of the signaling pathway leading to immature dendritic cell chemotaxis upon exposure to M-tropic gp120 1234 920 4046 PMC2766922__F2 Signaling pathways downstream of HVEM, LIGHT, and their binding partners are shown 613 151888 2885 11126 7187 7186 4703 PMC2770326__F2 Mammalian sialic acid metabolism 9365 4758 10825 4759 129807 6482 256435 6483 6487 6480 81849 6484 84620 8128 10402 51046 10610 7903 6489 338596 29906 27090 64841 5238 6675 10020 55907 140838 54187 PMC2772702__F6 The PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV 5163 2475 717 PMC2772826__F1 Apoptosis in animal models of virus-induced disease 8772 581 56616 PMC2775119__F3 Ciliary functions of cystoproteins: mechanosensation and cell cycle control 8100 5091 983 1021 1020 1019 3398 1017 PMC2775236__F1 The effect of neuronal activity on the function of the miR379-410 cluster member miR-134 23369 627 3984 PMC2776288__F3 Crosstalk between apoptosis and NFKB signaling by IAP-antagonist 7186 10454 331 PMC2777383__F1 Predictive Phosphorylation Signature of Lung Cancer 1956 5829 2697 5159 6714 2885 6774 2549 1398 2059 842 572 2475 4609 3725 PMC2777399__F1 Regulatory mechanism of the Rho/ROCK pathway activated by angiotensin II (ANG II) in vascular smooth muscles cells (VSMCs, see text) 1956 387 9748 PMC2778342__F2 Roles of the selected genes in the DSBR pathway 472 11200 7157 83990 672 59348 10111 2547 7520 675 7518 7517 8438 5888 3981 7516 5893 3014 5885 PMC2778737__F4 Nephron development and cell lineages 2297 10736 5979 7481 4435 54361 7091 PMC2779044__F4 Model describing the regulation of protein synthesis by AMPK, Ca++ and Akt -signaling pathways 7249 7248 6009 29904 1977 1938 PMC2784121__F6 NPM-ALK oncogenic tyrosine kinase controls T cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells 920 3932 7535 27040 6774 10451 7409 998 5879 387 1786 PMC2785342__F8 A proposed model for HA-CD44-mediated PKCE activation and Nanog signaling in the regulation of miRNA-21 production, oncogenesis, and chemoresistance in breast tumor cells 960 79923 29102 27250 331 PMC2785619__F2 Up-regulation of TGFB signaling in Timp3−/−-AB hearts 3624 10468 9241 652 2022 7048 6696 860 2280 25805 4087 4088 864 4086 3976 3725 3458 5595 1387 5054 6498 2353 6497 PMC2785637__F1 Schematic overview of hepatic lipid biosynthetic pathways 907 100379198 7038 10400 5662 PMC2785932__F3 Four pathways by which the EBV latent membrane protein 1 (LMP1) is thought to signal inside cells 7187 7185 7186 3718 8717 2646 1386 PMC2787631__F7 Working model of PKA’s role in trastuzumab resistance 5728 5164 5163 1956 PMC2787898__F1 TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice 7099 3661 7189 4615 114609 PMC2788154__F1 Signaling pathways that lead from activated KIT and aggregated FcERI to mast cell responses 3815 27040 7462 6714 2885 4067 6850 9846 7409 695 3717 6772 6774 PMC2789784__F2 Signaling pathway downstream of PI3K affect cell death and cell survival 5164 5266 2475 5163 PMC2790539__F1 Apoptosis in cerebral ischemia and reperfusion 355 581 572 637 2021 790 PMC2791157__F3 Decomposition of Gene Expression State Space Trajectories 952 6256 5914 1017 PMC2797318__F2 Promising bone-related targets for rheumatoid arthritis therapy 22943 4041 4040 324 1499 4086 51176 4089 PMC2797439__F1 Class IA PI3K signalling pathway 5728 5163 5266 7249 7248 6009 96459 201163 2475 PMC2801177__F4 Identification of candidate molecular network for miRNAs most highly changed in response to DEP 2104 5728 650 2059 4306 3309 1080 5308 8648 93 29068 659 2625 6616 7220 10294 2494 1051 57619 8451 10769 3842 PMC2801866__F4 NO/cGMP pathway is a signaling node for pro- and anti-angiogenic signaling 948 961 2534 6714 PMC2804818__F5 A summary of the ligand-mediated control of TRP53 expression via the PI3 kinase/AKT/MDM2 pathway 5724 5266 5163 PMC2807379__F4 Nephronophthisis: Disease Mechanisms of a Ciliopathy 4867 27031 261734 6469 55690 57560 PMC2807379__F8 Nephronophthisis: Disease Mechanisms of a Ciliopathy 6608 2737 5727 2735 2736 51684 PMC2810291__F6 Endonuclein functions 387 6774 6741 1636 PMC2810509__F2 BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN 1003 83605 3688 6010 PMC2811176__F2 Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction 64900 51773 1659 29964 5465 90362 64318 1407 8896 54680 7040 3172 27443 6683 55032 2247 56897 10559 4215 51154 23164 10856 3827 25987 54891 7512 1369 PMC2811231__F7 Gene program of neutrophil recruitment and tissue injury based on gene expression and in vitro data 3654 4615 960 3553 3554 2683 5743 2529 7097 3383 7130 3340 1241 1588 5329 2204 1437 2357 240 9536 5733 5739 PMC2814769__F5 Primary Cilium as a Complex Signaling Center 387 1499 4040 4041 2932 324 PMC2815088__F6 Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine 2475 8473 10724 11201 PMC2818223__F2 GSK3 regulation of STATs, Smads, Beta-catenin, and NFAT 6774 4040 4041 1499 940 PMC2818233__F2 Nuclear phosphoinositide-mediated stress response pathway 9978 8405 1616 3651 PMC2819585__F7 MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis 406921 4204 9055 2146 PMC2819730__F1 Urine-based assays for the detection of bladder cancer 348 7804 64399 50848 1495 57404 467 2321 7097 2782 183 8877 7037 5294 267 2549 2280 7046 2064 3953 655 2128 PMC2819802__F1 Activation of apoptotic and survival pathways by TNF 7124 8717 7186 637 4616 8772 PMC2820199__F3 Network of proteins, functional classes and cell processes modulated in prostate cancer cells after curcumin treatment 4792 581 596 1956 5728 PMC2821201__F6 A diagrammatic model to summarize the role and subcellular localization of survivin and its splice variants in the regulation of apoptosis and control of mitosis in cancer cells 991 3619 331 PMC2823977__F1 REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS 8717 7186 8772 581 2021 355 PMC2825553__F1 Interplay of cellular stress signals with apoptosis pathways 8772 637 581 331 PMC2828280__F2 Canonical Wnt pathway 7939 4040 4041 1499 324 607 4314 4316 102 7074 595 PMC2829627__F3 PPARG agonists inhibit Stat3-mediated IL-6 gene expression in myeloma cells 6774 7216 10682 PMC2831042__F7 Proposed model of neurite outgrowth pathway in postnatal SVZ/RMS-derived neurons 207 5879 998 PMC2832691__F3 Binding of Herpes Simplex Virus Type-1 Virions Leads to the Induction of Intracellular Signalling in the Absence of Virus Entry 6714 5970 3661 3665 4319 4316 4609 330 4790 5966 PMC2833108__F6 Sonic Hedgehog, Wnt and TGFB signaling pathway gene expression in CpG late treated macrophages [; ; ; ], see discussion 6469 655 6608 324 2932 4087 1499 4088 4685 PMC2836046__F7 Proposal of the regulatory loop of miR-24, miR-34a, and HNF4A in bile acid synthesis 1581 1582 1593 PMC2837270__F8 Seoul virus suppresses NFKB-mediated inflammatory responses of antigen presenting cells from Norway rats 649024 1440 6347 3586 4049 3439 356 8743 7096 7133 4615 3656 958 8837 9641 3659 841 4791 PMC2837572__F2 An overview of the signalling pathways mediated by TNFA in metastasis 7124 1447 1499 PMC2838378__F1 Simplified schematic of the IgE receptor (FcERI) signaling pathway 7462 27040 2534 4067 6850 2885 PMC2839281__F4 Pigmentation Pathway Evolution after Whole-Genome Duplication in Fish 1908 434 3815 4286 5077 6663 51176 1638 7306 PMC2841246__F4 COX-2 inhibitors on apoptosis 572 581 637 56616 842 836 1499 8772 PMC2842081__F1 Telomeres: protecting chromosomes against genome instability 1200 25913 641 7486 472 545 7015 1736 PMC2844056__F7 Genes involved in cell-cell signaling significantly associated with ERbreast cancer cells in response to AA 7124 22900 843 1473 842 8406 57099 581 572 22861 1302 PMC2844310__F3 Relationship of NFKB to genes identified as “linearly” changing with age on the basis of cocitation analysis (Genomatix BibliosphereTM) is shown as a Bibliosphere image 11319 1674 10266 4790 7077 4868 4846 PMC2849646__F3 Frequent amplification and overexpression of multiple EGFR-family-signaling components in non-small cell lung cancer (NSCLC) 2885 6464 1020 207 1956 PMC2855642__F2 Glycosylation of Alpha-dystroglycan 10585 29954 55624 79147 2592 PMC2857176__F3 Map of selected p53 pathway-associated genes that harbor known or potential functional SNPs (octagon-shaped boxes) and their closely interacting genes (rectangular boxes) 840 355 7161 472 7157 4193 4194 1017 1019 4609 PMC2860895__F1 TOM1L2 and genes associated with Alzheimer's disease in the human interactome 5663 351 85021 7781 348 284111 5664 5870 51560 64849 169026 2952 6812 9230 54677 30846 23673 25827 9353 9444 3929 421 146691 23558 10589 3801 23327 23416 816 8722 25824 152831 54805 30845 PMC2861543__F6 Differential role for endocytosis in receptor-dependent Nox1 generation of ROS and activation of cellular signalling 1956 27035 466 PMC2864389__F1 PI3K/AKT signaling pathway 5266 572 7249 4193 4303 PMC2864813__F4a Substance P in Polymicrobial Sepsis: Molecular Fingerprint of Lung Injury in Preprotachykinin-A−/− Mice 3557 6280 4317 3934 4318 6279 6357 6289 3553 5328 2357 1230 5781 9021 PMC2869094__F1 Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia 11197 1499 1855 2932 324 1856 5515 83737 607 595 51176 894 896 4609 7089 7088 8061 3725 4040 4041 999 PMC2871738__F2 Molecular determinants of mitochondrial quality-control networks 4221 9927 550 51024 11337 4077 4976 PMC2871799__F6 Human endometrial receptivity 8646 4151 1634 10468 5627 5624 654 5648 5345 2147 717 718 5340 2244 4088 5880 3683 3689 83700 7046 624 PMC2872667__F3 Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling 2263 2260 8324 200958 4684 860 1000 632 7852 2335 1956 8038 858 51199 1793 5764 PMC2872667__F4 Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling 5796 5764 1634 6678 4313 3486 1191 10631 1958 7078 3339 6662 5350 54360 PMC2872883__F2 TIF scores for genes in the KEGG colorectal cancer pathway 6418 351 3845 23533 5290 5291 5293 5294 5295 10000 207 208 572 5900 5594 5595 5599 6934 83439 5604 51176 5879 6010 3725 2353 4609 332 673 595 PMC2873428__F8 Sequencing, Analysis, and Annotation of Expressed Sequence Tags for Camelus dromedarius 8195 2932 9817 PMC2873801__F4 Relationships between differentially expressed miRNAs, putative target genes, and functions 23530 4335 10252 65986 4063 54726 4319 445 284217 1512 100049579 3949 4693 140597 9659 115701 397 10538 2731 1192 467 10769 272 9111 1999 10243 596 3543 133 51316 PMC2885101__F2 PI3K/Akt signaling pathway 3479 5163 572 PMC2888472__F2 Simplified scheme of signaling pathways required for maintenance of pluripotency of mESC (top panel) and hESC (bottom panel) 3976 6774 4090 4086 79923 4087 4088 PMC2888474__F2 Genetic Alterations in Glioblastoma Occur Frequently in 3 Cellular Signaling Pathways 1956 2064 5156 5728 4763 1029 1030 1031 894 1019 1021 4193 4194 5925 PMC2888634__F4 Drug-induced DNA damage may be repaired by various DNA repair pathways, or apoptosis may be triggered as a result of attempted repair of platinum-induced damage by the Mismatch Repair pathway 7508 7507 2067 5886 10013 7515 2177 7516 5888 672 2272 146956 10641 6240 1719 PMC2889681__F1 Neurotrophic and neuroprotective pathways targeted by lithium 627 2932 4082 572 1499 PMC2901551__F1 mTOR signal pathway 3667 5728 5163 79899 55615 64798 2475 253260 64223 7249 7248 6009 PMC2903433__F4 Chloride Regulation in the Pain Pathway 65267 130497 65125 65266 9341 6844 1121 PMC2904682__F1 Schematic model of regulatory pathways involved in Mycn stabilization 238 3480 5163 253260 2475 5164 2931 983 4613 5300 PMC2904914__F2 Glial cell line-derived neurotrophic factor can signal through a Ras-induced pathway in SSCs 2668 2674 5979 2885 466 1017 PMC2907574__F4 Inhibition of host signalling pathways by VACV members of A46 and related families 7096 7097 10333 7099 4615 114609 7098 54106 51311 51284 51135 3656 3654 7189 10454 7187 23118 1326 3665 29110 3661 PMC2907875__F8 Estrogen and Xenoestrogens in Breast Cancer 3084 29091 654 10252 5915 PMC2908393__F4 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy 4035 3949 7436 3416 PMC2908393__F5 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy 348 4035 3949 19 PMC2908475__F2 The intracellular signaling network regulating T-cell trafficking and differentiation 3558 3600 59067 50615 5728 5163 8320 604 6402 1236 PMC2909548__F4 Protein-protein interaction maps comprising the transforming growth factor B signaling pathway of transcription factors associated with liver cell proliferation 5977 55422 7551 2783 199777 79797 4849 3399 468 2274 7988 4792 1445 467 7803 64764 2664 2794 PMC2909662__F1 Signaling pathways of TLR4 7099 7097 7096 4118 4615 7098 7189 7187 5970 3661 PMC2910728__F6 Absence of Inhibin Alpha and Retinoblastoma Protein Leads to Early Sertoli Cell Dysfunction 2492 90 595 894 1019 4088 1869 317 1029 27113 PMC2914056__F6 Pathway packaging of the 'biopolymer metabolic process' module 6117 6118 2956 7158 993 4683 995 83990 595 3725 1263 2175 1869 4436 PMC2916406__F7 New model for a novel role of p38 MAPK in the DNA damage response in cancer cells 545 472 983 PMC2916838__F8 NPRL2 Sensitizes Human Non-Small Cell Lung Cancer (NSCLC) Cells to Cisplatin Treatment by Regulating Key Components in the DNA Repair Pathway 10641 472 993 995 PMC2917029__F8 Molecular pathway initiated by P4 signaling in BPBC cells 1950 857 1956 5728 PMC2919655__F3 Diversity in Post-Transcriptional Control of Neutrophil Chemoattractant Cytokine Gene Expression 3554 3556 84818 4615 51135 7189 PMC2921082__F4 Dual regulation of fuel metabolism and cell viability by adenosine monophosphate-activated protein kinase 3667 8660 7248 2475 2932 PMC2921274__F2 Eph receptors and ephrins in cancer: bidirectional signaling and beyond 1969 2048 3265 6714 999 PMC2921605__F1 PIK3/Akt/mTOR Pathway 2475 5163 5728 1977 PMC2922222__F1 Conserved ATR→CHK1 checkpoint signaling pathway in eukaryotes (, ) 545 11073 84126 PMC2922518__F1 Schematic illustration depicting the cellular pathways that lead to eIF4E activation and phosphorylation by Mnk1/2 5728 7249 7248 6009 1999 1977 6354 4170 4318 6347 4314 PMC2927346__F1 Irinotecan pharmacogenomics 1066 8824 590 55775 4790 7515 7150 54658 54659 54600 1244 5243 9429 PMC2929667__F6 Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation 2690 3667 8660 3717 5163 6777 3479 3483 3175 2308 2645 3170 10891 3484 5105 PMC2930673__F2 Transport of heme synthesis intermediates and heme in metazoans 54977 10058 1371 5498 2235 9429 571 PMC2930807__F4 Gene pathway analysis 9370 5465 2180 5563 5105 5577 3991 5836 5140 31 5837 10580 4023 2932 2321 22885 8322 487 2934 88 2770 7125 1387 3707 200734 4158 PMC2933544__F3 Proposed model of epidermal growth factor receptor (EGFR) aberrant activation and trafficking in the setting of cigarette smoke (CS) 1950 1956 2885 1431 PMC2933688__F3 EGFR signaling and NHEJ 1950 7039 1956 5728 5163 PMC2935989__F3 GRK2 interactome involved in the modulation of cell cycle progression 1017 6608 156 5300 983 2305 PMC2937064__F1 Leptin, IGFBP3, and rapamycin suppress the IGF-1 signaling pathway to preserve naïve T cells and promote longevity 3717 3486 939 3479 6774 5163 2475 PMC2939362__F1 Domain organization of proteins in the Hh signaling pathway 91653 64399 100188011 1950 2619 2335 6608 2821 PMC2940266__F1 Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles 5728 5163 572 2475 4193 2931 2932 PMC2944409__F7 Gene interaction sub-network of shortest connections to common targets for the 36 candidate regulatory genes obtained by global literature analysis (Pathway Studio 7.0, Ariadne Genomics Inc., Rockville MD) 3275 7072 7124 57187 4734 7070 183 7852 5743 1956 6352 5618 8899 7412 999 595 2335 7076 72 4323 7422 596 4313 4318 2697 3383 PMC2945950__F1 BCR signaling pathway 933 6850 613 4067 29760 695 2885 66037 1610 8915 930 PMC2945950__F5 Moral graph Dm obtained from BCR pathway 933 6850 971 4067 29760 695 5336 25780 2885 8915 975 2932 930 PMC2947178__F8 Model for the Coordinated Action of the Mating Types to Regulate Different Stages of Pathogenic Development of U 5551 10978 10519 PMC2948497__F6 cDNA Microarray Gene Expression Profiling of Hedgehog Signaling Pathway Inhibition in Human Colon Cancer Cells 1026 1030 990 993 9212 991 9134 7298 7153 7083 5427 1870 5426 890 1649 54541 1017 995 983 891 9133 PMC2949127__F3 HMGB1 signaling events mediated by RAGE and TLR2/4 and therapeutic strategies for cerebral ischemia 3146 7097 7099 4615 998 5879 7189 PMC2951628__F1 Inflammation Joins the “Niche” 6279 6280 7099 100187761 PMC2952128__F4 Functional gene networks identified using IPA from differentially expressed genes between control and 300 nM reversine-treated annulus fibrosus cells 3655 7832 1604 8995 22974 26586 5005 5081 151613 648 7157 65082 54474 23397 822 255082 24137 11080 79026 9918 7092 1264 PMC2952980__F1 Multifactorial pathway leading to gastric carcinoma 3553 6492 7099 PMC2954288__F10 Hypothetical model for SWAP-70 function in mast cell FcERI signaling 27040 3565 3566 847 PMC2955614__F5 Novel molecular regulation of Wnt/Beta-catenin pathway 999 1956 1499 2932 9839 6935 324 6774 207 6477 1869 23043 9314 8841 3065 2637 2296 27287 PMC2956014__F2 Neutrophil apoptosis 7124 8717 8772 637 581 4170 317 2021 331 7186 PMC2957472__F3 Helicobacter pylori: gastric cancer and beyond 4041 4040 999 1499 2932 324 PMC2957893__F3 Genes in one pathway have complex “net” interactions, which should be taken into consideration when analyzing proteomics/genomic data 472 4193 983 999 5111 1021 1019 PMC2958130__F5 Intertwining Threshold Settings, Biological Data and Database Knowledge to Optimize the Selection of Differentially Expressed Genes from Microarray 3929 7099 929 23643 7189 3383 7412 4318 PMC2958340__F3 Canonical Wnt/Beta-catenin signaling 7045 51701 1499 PMC2964046__F1 Currently-known relationships among genes analyzed based on manually curated examination of the published literature within the Ingenuity Pathway Analysis® Knowledge Base 6281 1459 7046 6303 51604 3240 9429 2170 7040 2475 5468 8694 696 207 948 7498 1915 123 3488 1075 2180 3486 2149 3638 182 22937 6721 84649 4609 6319 4582 6648 47 4057 4313 2194 4069 1447 31 7124 6513 826 7069 718 10272 3992 1448 3906 2876 PMC2966484__F3 Activation of the NFKB signaling pathway 100420631 6500 9978 8454 PMC2966895__F2 Complement-targeted therapeutics 718 717 1356 721 720 716 4184 1378 966 PMC2974943__F2 Intracellular signaling pathway within cranial neural crest cells mediated by endothelin-1 (Edn1) 5045 1906 9718 1889 PMC2978721__F8 Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells 95 2182 706 1622 10965 PMC2983087__F2 Mechanisms of double-strand break repair in somatic mammalian cells 580 672 79728 5888 675 PMC2983445__F3 Growth factor signaling pathways mediating survival in multipotential stromal cells 1950 3082 1956 2308 331 596 572 PMC2984446__F10 PI 3 Kinase Related Kinases-Independent Proteolysis of BRCA1 Regulates Rad51 Recruitment during Genotoxic Stress in Human Cells 338340 580 672 5888 PMC2984500__F2 Selection of miRNA implicated in the TLR4 signalling pathway 7099 10043 8651 54472 51135 3654 7189 4615 114609 4118 PMC2987346__F2 RSK signaling pathway 3897 2885 572 1975 1938 6722 468 PMC2989631__F1 DNA damage response (DDR) pathway 472 9025 8924 165918 9656 672 PMC2990406__F8 A previously unknown miR-290–dependent pathway controls DNA methylation via Rbl2 and affects telomere integrity and telomere-length homeostasis 100187761 5934 1788 1789 PMC2993607__F1 RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? 4609 1499 990 983 1021 1019 648 PMC2999098__F3 CKI members in canonical Wnt signaling 324 6929 2353 3725 PMC3001129__F2 NOD-like receptor signaling beyond the inflammasome 4615 79671 23586 3654 64127 10392 91662 3458 PMC3005738__F1 Metabolic pathway of tamoxifen 6817 1565 1559 1555 8205 1557 9 PMC3012004__F1 PI3 kinase signaling pathway in glioma 3480 1956 5728 5163 2932 572 7249 7248 595 2475 253260 PMC3013243__F9 Myeloid-specific GPCR kinase-2 negatively regulates NFKB1p105-ERK pathway and limits endotoxemic shock in mice 7099 156 3553 PMC3021368__F5 Foxo3 controls DCs functions 2309 596 6648 1493 PMC3021995__F3 Post-transcriptional control of mammalian clock genes 8864 1407 3184 PMC3022001__F12 Schematic representation of effect of depletion of the syntaxin-5 complex on the autophagic pathway 27131 100170220 9554 PMC3022823__F9 FBPA clustering on gene expression in the bystander response 64332 718 1050 3725 5971 4609 9518 1053 10912 8626 2539 4780 6667 8794 3589 1026 9611 4223 5970 1869 1387 10365 668 3661 53344 3592 8850 7538 3217 4493 1051 5743 7409 1052 2033 PMC3023296__F3 Cell cycle, cellular growth and proliferation pathways detected by ingenuity pathways analysis 6547 201163 85455 4801 7531 10043 27072 23089 1029 3172 4849 6233 8872 27130 29933 54788 3767 PMC3023615__F2 In fibroblasts, Nod2 senses bacteria at the plasma membrane and recruits the autophagic machinery through direct interaction with ATG16L1 64127 9140 29880 PMC3026990__F5 Signaling networks associated with PPARD and inflammatory and invasive gene expression 5467 4322 177 836 1956 6402 2006 4321 4313 2247 4318 842 2920 4137 4353 3551 6372 998 3055 PMC3037032__F4 The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes 4152 22992 729 PMC3037747__F2 Cyclin D1, at the center of MCL pathogenesis 595 472 2475 81620 2932 1021 1019 1017 PMC3037747__F4 BCR, NFKB, and PI3K/AKT/mTOR deregulation in MCL 613 5728 29760 7249 11124 5970 5971 331 PMC3039924__F1 Insulin-like growth factor receptor 1 (IGF1R) signaling pathway and potential mechanisms of resistance to IGF1R blockade (red asterisks) 1956 3643 3482 3667 5728 7248 5163 572 6009 2475 253260 1977 PMC3039931__F2 Tyrosine kinase pathways leading to CARD9 and TLR signaling responses 6850 64170 10892 4615 7006 100124696 PMC3044157__F6 The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage 10276 1894 388 PMC3045450__F4 NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs 5296 11315 6009 2308 1977 6198 5728 7157 5163 207 7249 5290 7248 1978 PMC3045531__F9 Snail repressor is required for PMC ingression in the sea urchin embryo 8092 2113 4151 PMC3046427__F2 Beta-Catenin is at the hub of multiple signaling pathways 4041 4040 324 6500 6477 1956 2064 3611 2146 2932 5300 6714 2241 1499 90780 51701 595 64321 PMC3048826__F8 Hsp72 regulates oxidative stress-induced HMGB1 cytoplasmic translocation and release 3920 3146 3065 PMC3049961__F8 Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR 6383 1956 8502 2549 2697 5335 5829 5578 64759 9564 5594 6461 6714 5747 1018 54206 1022 4739 6777 PMC3051001__F1 RIP1 COMES BACK TO LIFE AS A CELL DEATH REGULATOR IN TNFR1 SIGALING 7124 958 7186 PMC3051184__F9 Proposed model explaining upregulation of CREB expression by RA in NHTBE cells 6667 6668 108348018 108348016 PMC3057579__F9 Hypothetical diaphragm of HS7 induced apoptosis and inhibition of Wnt/Beta-catenin signaling pathway in HT-29 colon cancer cells 581 1499 7008 4316 PMC3059896__F2 Genetics and molecular pathology of Stargardt-like macular degeneration 2176 8749 5199 84839 PMC3060774__F3 Chromatin remodelling during development 2186 1105 53615 6657 79923 PMC3061066__F7 Model demonstrating the possible mode of action of hSSB1 10111 472 9656 PMC3061571__F2 Two different ubiquitin ligases control the stability of the Aurora-A and Polo-like kinases 324 55743 991 999 5347 246184 PMC3062054__F2 Roles for Growth Factors in Cancer Progression 4087 4088 4092 4091 4089 5728 572 2077 4609 2353 PMC3063577__F2 Simplified diagram showing some of the identified BCR pathway members 3932 2534 79930 638 3055 4067 6850 2475 29760 695 5336 971 PMC3064222__F9 Proposed signal transduction pathways in NG following receptor activation with leptin and CCK-8 886 3717 387 718 6774 466 PMC3064559__F3 Interconnectivity of signaling pathways emanating from TLRs and TACI 4615 3654 51135 7189 57379 7186 7188 PMC3064890__F5 BRCA2/RAD51 pathway in the response to stalled forks 675 5111 84126 545 472 56946 PMC3069496__F1 miRNA biogenesis pathway 29102 54487 26523 192670 27161 192669 1233 PMC3069685__F2 An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy 10818 5058 64764 22809 4170 PMC3075510__F9 Phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3 (GSK3) signalling is required for expression of a subset of interleukin-10 (IL-10) inducible genes 6774 9021 9915 PMC3077649__F7 Model of Egr-1/GGPPS/Erk1/2 pathway regulating insulin resistance in hyperinsulinism 2885 126669 6654 1958 PMC3081180__F7 The participation of MCP-1, TNFA, MMP-9, E-cadherin, and Beta-catenin in macrophage fusion 3566 999 729230 7124 4318 PMC3082499__F2 Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling 355 7124 8717 8772 1616 637 PMC3083942__F3 Proposed model for Syk in mediating oxidative stress-induced calcium release 4067 6850 29760 695 PMC3085878__F3 TLR-induced microbial resistance 7096 7099 7097 10333 7100 929 51135 7098 51284 51311 54106 3656 3654 7189 7187 23118 10454 10010 29110 3659 3663 3661 PMC3087899__F6 NFKB pathway activation via death receptor signaling 8772 8717 7186 108348016 7185 331 7124 PMC3090458__F3 BAFF and APRIL signaling pathways in B cells 7099 7188 7189 4615 7186 7187 54106 51284 51311 10454 PMC3091595__F2 Bcl-2 as an attractive target for modulating different modes of cell death in cancer therapy due to close communications with mediators of apoptosis, programmed necrosis, and autophagy 8717 8772 637 581 2021 PMC3091695__F3 Stress-induced pathways in the PVN of the hypothalamus of DBA/2J (A) and C57BL/6 (B) mice 4772 5062 2771 108 7124 1950 4830 10253 5997 2775 351 PMC3092200__F9 Hypothetic scheme of cell death induction pathway triggered roscovitine and CR8 in human neuroblastoma (NB) cells 1025 1022 902 PMC3093193__F2 Update on the regulation of mammalian melanocyte function and skin pigmentation 5443 4803 4804 3082 3815 1906 1908 1910 4157 2934 6662 4286 7306 1638 3084 PMC3093880__F8 miR-122 and liver-related functions and diseases 392 25932 5770 6541 27183 226 4134 4316 7431 2530 587 2539 2997 7052 2355 1431 5829 978 10007 4131 6508 PMC3093880__F9 Associations among miR-122-identified targets 5630 10298 7205 7431 9341 5411 5879 6513 6597 5604 8061 10988 1385 3725 2355 28964 4316 5770 5829 4638 1051 392 2539 6844 4282 1465 978 6515 PMC3096194__F1 Cell cycle is controlled by the Rb pathway and p53 pathway 1029 4193 1017 1019 7018 PMC3099033__F9 Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling 7248 7249 6009 6194 PMC3107442__F5 Transcripts (p < 0.05) involved in cell signaling 5582 2914 2912 2571 2572 PMC3108097__F1 Iron Homeostasis and the Inflammatory Response 57045 9518 7018 148738 3077 7036 10682 7494 PMC3110626__F1 Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome 5290 5295 5291 5296 5728 5294 8503 30849 5293 207 2475 208 5163 10000 572 7015 4193 595 5934 PMC3110643__F7 Cartoon representing CsA-mediated activation of TGF B1-dependent signaling leading to epithelial-mesenchymal transition in epidermoid carcinoma cells 4087 4088 4092 4089 999 6667 1000 PMC3110895__F4 Modeled miRNA mediated pathways in the pathogenesis of lung fibrosis 7124 355 324 581 PMC3115901__F4 The core biochemical network of the ceramide/sphingosine-1-phosphate rheostat 2729 1066 91012 55304 2864 PMC3116244__F1 Signaling Pathways Altered in Hepatic Cancer Stem Cells 1499 6868 1045 2932 2274 324 51176 595 2475 4072 572 5728 619501 7015 6774 3481 3482 PMC3121188__F7 ERK-dependent signalling during conditioning and extinction of fear 122953 3727 2191 PMC3126159__F4 Temporal regulation of apoptosis in SeV-infected cells by PI3K 23586 3661 29110 581 317 331 PMC3129504__F2 Ras/Raf/mitogen-activated protein kinase pathway 1950 2885 673 5900 1956 PMC3132567__F8 Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1A Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression 1950 1956 7428 PMC3133224__F9 Molecular interplay between FBXL2, its substrate CCTA, and CaM controls phosphatidylcholine (PC) synthesis 25827 6500 7316 907 PMC3135646__F1 P53 pathway in development, cancer, and reprogramming 4609 648 472 545 4193 581 406985 PMC3136937__F4 Identification and Analysis of Signaling Networks Potentially Involved in Breast Carcinoma Metastasis to the Brain 7157 64393 7431 6533 4151 3181 6188 7428 2547 2022 55664 6204 140462 4678 51499 3304 3281 8993 PMC3137145__F3 Cigarette smoke exposure induces autophagy and apoptosis 9474 9140 1958 23192 10533 64422 PMC3137710__F2 Chemical ‘Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways 324 1499 2932 8312 80351 8313 PMC3139189__F3 Common pathway of anoikis induction 6714 836 572 90427 56616 842 PMC3141233__F7 A model for the role of FANCD2 in Ad replication-dependent recombination 2177 641 545 PMC3141988__F6 An E-cadherin–mediated Hippo signaling pathway 999 4485 9113 26524 PMC3143653__F6 Ingenuity pathway analysis of PKCAlpha-CT regulated, MEF2-targetted cardiac mRNAs 6850 7462 7042 7157 3565 221458 7124 5468 2026 9049 3596 467 1051 7145 6698 PMC3143906__F3 Multiple factors and pathways affect insulin-like growth factor 1 (IGF1)-Akt signaling 3479 7124 3611 5728 5163 5337 PMC3144045__F1 Signal pathway activation by different surface PRRs 6714 4615 4118 6850 3656 3654 51135 64170 10892 7189 8915 3077 PMC3145765__F9 Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes 581 836 840 4134 7018 PMC3146054__F2 Regulation of microsomal triglyceride transfer protein 3643 5163 5164 4547 PMC3148591__F2 Major signaling pathways of IPC- and Ipost-mediated protection against cardiac cell death 3717 5163 6774 PMC3150418__F9 NFKB signaling participates in both Receptor Activator of NFKB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NFKB pathways 5970 5971 81501 960 999 PMC3151145__F1 Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling 929 3949 948 9619 7099 4864 10577 3156 38 PMC3151419__F6 Regulation of the mTOR signaling pathway by insulin and growth factors 3479 5163 3667 5728 7249 7248 6009 64798 2475 64223 253260 PMC3151419__F7 Regulation of mTOR pathway by Sestrins 7248 27244 83667 6009 7249 PMC3153113__F7 Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth 1938 7249 7248 6009 2475 83939 1998 6194 PMC3154612__F1 Simplified diagram illustrating the mTOR signaling pathway 5163 2475 1977 1975 PMC3156642__F1 Crosstalk between the canonical and non-canonical transforming growth factor-beta1 (TGFB1) and myostatin pathways 4092 4087 4088 4089 PMC3157296__F8 Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth 2146 1958 367 5728 3725 2289 2475 PMC3158739__F1 Ingenuity pathway analysis (IPA) of CDF driven pathway changes in BxPC-3 cells 858 9429 1281 369 6678 5782 1677 10553 1499 4609 406887 131405 PMC3159046__F6 Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood 1001 27253 1006 1012 7476 659 7048 7046 8324 1499 23002 2932 4776 1387 PMC3159114__F1 Modulation of cellular reactive oxygen species (ROS) 50507 2876 57716 PMC3159580__F3 Not(ch) just development: Notch signalling in the adult brain 6469 92737 2152 51162 8650 627 2475 1499 6774 6657 595 1017 3516 3091 PMC3159974__F4 Predicted synthetic lethal gene pairs in TCA cycle (A), phosphatidylserine biosynthesis (B) and pentose-phosphate pathway (C) 2539 5091 25796 5226 6120 22934 5833 10390 81490 9791 56994 PMC3160745__F1 PI-3K/Akt signaling pathway 5163 5728 3667 4193 2475 2932 572 PMC3161675__F3 Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer 1019 595 4609 648 6909 6926 1758 3726 4193 PMC3166203__F13 Redoxosome formation in IL-1 signaling 6647 3654 7189 5879 4615 PMC3171365__F2 Bayesian network fits for mutation data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1); (b) Bayesian Information Criterion (maximum indegree of 2) 5932 2189 7157 9134 545 997 5925 901 1029 PMC3171365__F3 Bayesian network fits for wildtype data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1) 901 7157 997 1029 2189 5932 9134 5925 545 PMC3171706__F1 G1/S transition and G1/S checkpoint induction 472 4193 1019 1017 4173 4176 4172 4171 4174 4175 81620 4998 990 8318 PMC3171706__F3 G2/M transition and G2/M checkpoint induction 472 545 4193 5347 79866 983 4661 7465 PMC3175613__F3 Proposed in vivo innate and adaptive immune responses to AAV vectors 1378 6352 54106 920 PMC3175639__F2 Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2 54809 7424 27033 5366 2633 10628 3458 23304 3569 1048 634 4680 3556 PMC3178084__F2 Runx2-deficient cells exhibit suppression of genes by insulin at multiple stages of the signaling pathway 3480 3949 2885 6654 6720 10682 860 PMC3179879__F5 Abrin (ABR)-triggered apoptosis 137735 6098 581 PMC3180046__F2 NFKB signaling pathways 613 4055 958 7187 3654 51135 7186 7189 8915 1540 23118 10454 5971 5970 64236 PMC3180107__F2 Molecular mechanism of autophagy and its role in cell death and survival 7405 572 9776 2475 PMC3181269__F1 Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis and Signaling 137964 84803 150763 4018 10554 56894 10555 4245 4247 5091 8694 84649 PMC3184252__F6 Pathways of androgen biosynthesis 412 3293 1586 8644 3294 6715 3028 5959 1646 PMC3185579__F3 TLR-dependent and independent IFN-I induction, signaling and action 54106 51284 7098 4615 3663 29110 3665 1386 3661 4599 6041 135892 3669 9636 10379 6772 7297 3716 6773 PMC3185611__F1 PRRs involved in detecting flaviviruses 3439 7098 7189 7187 3661 PMC3187934__F2 Phosphorylation pathways adapted from KEGG (50)(51) 3480 3667 2885 7248 2475 7249 PMC3193279__F1 VEGF Signaling Pathway within endothelial cells 2321 7423 2247 7078 5281 3791 3685 1398 1445 10818 2885 5770 6654 5894 4846 PMC3193402__F1 Classical and alternative NFKB pathways in skeletal cells 7124 108348016 5971 PMC3193406__F2 Positive and negative domains regulating p100 processing 6007 9978 5966 8454 6500 PMC3193436__F1 Model describing the proposed role of Rap1GAP in the control of GDNF-induced Ret signaling 2668 5979 2674 55715 5909 7074 7410 998 5879 PMC3193496__F2 HIPK2 and NLK/LIT-1 in Wnt signaling 28996 51701 6925 6929 10940 7473 7471 PMC3196718__F4 Network of upregulated genes in C2C12 cells treated with rhBMP2 and rhBMP7 using the STRING 9.0 pathway analyzer 572 23411 81621 4846 4303 148979 5654 3399 207 1385 10428 85409 8312 5351 1499 51295 23002 4086 169792 22943 4040 57216 3398 89780 2896 3397 10631 PMC3197858__F1 Fatty acid synthase as a potential therapeutic target in cancer 47 31 2194 95 PMC3199545__F1 Schematic diagram illustrating some of the major abnormalities related to sensitized D1R-signaling and associated to LID 627 5173 23237 PMC3200079__F3 Homeostatic and leukemic expression of receptors, signaling proteins, and transcription factors along the B cell pathway 10113 3575 1879 5079 930 3716 3717 PMC3200456__F1 Toxoplasma gondii effectors are master regulators of the inflammatory response 3458 3553 834 PMC3202104__F2 EBV infection impacts on cell death and survival pathways in GC B cells 613 958 355 8772 4089 4087 638 581 PMC3205612__F1 Interplay between autophagy and intracellular pathogens 2475 8408 9706 22863 7408 9961 3458 PMC3206016__F9 Putting into Practice Domain-Linear Motif Interaction Predictions for Exploration of Protein Networks 387 395 10276 9223 PMC3206266__F3 Androgen biosynthesis in the prostate 1583 1586 3283 6715 1646 8644 1645 8630 PMC3207219__F1 ROCK signaling pathway with focus on survival and regeneration 4018 1270 4099 387 5728 7248 7249 6009 84894 PMC3209802__F1 Assembly of checkpoint and repair machineries at DNA damage sites 9656 472 9025 3014 PMC3214273__F1 Pathogenic microbes and community service through manipulation of innate immunity 727 7852 7099 7097 7096 761 2932 PMC3215886__F2 The “inhibitory” pathway of WNK4 65266 65125 65267 PMC3218055__F3 Proteomic Signatures of Human Oral Epithelial Cells in HIV-Infected Subjects 4905 811 5037 1382 51474 7431 6623 2934 7430 197 7266 10419 5052 136319 PMC3219052__F1 SRC-3Δ4 isoform acts a signaling adaptor for EGF-dependent cancer cell migration and invasion 1950 2885 4690 1956 PMC3221387__F1 Impact of miR-215 on cell proliferation, cell cycle, chemoresistance, and EMT 9839 51514 1719 8317 4172 PMC3222593__F2 Pathway Studio® (Ariadne Genomics) was used to identify known relationships among human homologues of the genes identified as differentially regulated by ANOVA 4609 2353 7054 367 2597 55163 3065 8470 2099 5465 2875 1637 60 335 3630 PMC3226036__F5 A schematic representation of the two classical apoptotic pathways in mammalian cells 355 8772 8213 637 56616 PMC3230512__F1 Model showing the various molecular components associated with the store-operated calcium entry pathway 7220 84876 857 6786 PMC3234240__F2 Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays 55847 72 5164 3567 5165 351 4624 7124 1385 4697 4716 6622 1160 1346 PMC3239343__F2 Intracellular signalling during inflammation-induced osteoclastogenesis 7124 126014 3554 8717 4615 51135 6850 7189 7006 100124696 695 7186 7188 4772 100187907 PMC3240715__F3 Molecular mechanisms of FGFR3 signaling in cartilage 3976 3569 1267 3977 2261 10818 2885 6654 2549 8651 9021 6772 6774 3549 PMC3241001__F1 Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry 4040 4041 5728 5163 324 7249 2932 7248 1499 6009 2475 1977 PMC3241604__F7 Proposed MAPK pathways and their inhibitors involved in EVT dysfunction during an inflammatory state 3654 51135 7189 7099 4615 PMC3241725__F2 Bacterial manipulation of mitochondrial cell death pathways 1956 572 581 6389 596 2885 1398 664 842 836 PMC3242749__F4 Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice 27429 468 596 637 581 PMC3243033__F1 Regulation of epidermal homeostasis by PCP signaling 57216 81839 7481 115908 80199 3535 2239 5754 10399 9620 1952 1951 22881 4920 57822 23002 5879 998 387 PMC3243091__F2 Molecular control of palatal shelf growth and patterning 1947 2255 2048 6474 657 652 6469 4487 4330 50945 4223 56033 116039 130497 2252 PMC3246369__F2 Small RNAs in transcriptional gene silencing and genome defence 26523 23237 11261 63928 PMC3247990__F8 Post-induction repression of IFNB expression by YY1 in TLR3 signaling pathway 7098 5971 29110 7528 3661 3665 5548 PMC3251560__F8 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes 7703 8535 7283 11047 6505 10381 9223 7851 PMC3253915__F2 Innovative Therapy for Classic Galactosemia - Tale of Two HTS 1950 1956 5728 2592 PMC3255316__F1 Factors affecting the viability of dopamine neurons 4129 2668 627 1814 793 56922 1813 84660 PMC3256223__F1 Modeling of miRNA and Drug Action in the EGFR Signaling Pathway 1950 1956 572 7157 PMC3256849__F6 A model for Kv1.3-mediated signaling pathway in human T effector memory cell differentiation 4087 4088 4089 891 983 PMC3257556__F2 Known components of the PCP signalling pathway and related cellular functions 79633 8323 7976 1855 1856 166336 9620 81839 57216 144165 80199 27152 387 5580 388 2487 5754 7474 5879 7481 998 6093 PMC3259275__F2 ATM interaction with metabolic signaling pathways 2876 472 3480 2539 3479 PMC3260552__F4 Melanoma signaling networks, progression, and influences by the BCL-2 family 5728 4286 4170 90427 572 581 PMC3265021__F2 Signal transduction events that link ER stress to inflammation 22926 1998 7186 468 PMC3265661__F1 Putative role of the mTOR pathway in pathogenesis and epileptogenesis of focal cortical malformations 92335 7248 7249 6009 2475 1977 PMC3265777__F2 Context-dependent regulation of Rho GTPase signaling 1894 388 836 389 3985 PMC3269658__F5 Differentiation pathways of CSCs 650 652 1270 2475 658 657 3280 3399 3397 3726 9021 6657 2670 PMC3270058__F9 Endothelial adaptive response to moderate hypothermia (25°C/72 h) 3615 9601 6240 7054 284355 10135 2023 4678 3146 9987 83746 7767 8815 PMC3271045__F4 Schematic summary of striatal gene expression changes in response to SNCA overexpression 4280 9607 7276 1718 627 6854 7052 4208 1813 2911 PMC3272823__F3 Involvement of the ERK pathway in the TGF-Beta-induced epithelial-mesenchymal transition 3082 2885 4087 4088 4089 999 1958 PMC3275810__F2 Schematic display of the molecular interactions of apoptosis related molecules in dental apoptosis indicating the central position of the mitochondria pathway, which has been shown to be essential 1896 10913 8772 331 581 PMC3276974__F2 Hypothetical model of LRRK2-mediated regulation of the miRNA pathway 120892 1977 83876 PMC3278889__F4 TLR4 signaling to NFKB 7099 4118 4615 3661 7189 23118 10454 PMC3278889__F5 T-cell receptor (TCR) signaling to NFKB 940 5091 84433 5163 8915 10892 PMC3282989__F2 Recapitulation of heart development can provide useful insight for optimizing differentiation protocols 4838 1386 2626 PMC3286973__F2 Cell-line subtypes have unique SuperPathway network features 824 661 1973 860 586 7538 7157 9112 1871 4149 4609 8886 4088 4436 5604 6502 1019 2305 5601 814 6469 23761 8498 3170 6647 1499 338 2641 7031 7494 1462 7448 894 354 PMC3286973__F3 Pathway diagrams can be used to predict response to therapies 8626 839 355 604 11200 1263 7157 472 1111 1647 2064 2066 2069 2065 PMC3291810__F8 PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling 2549 5058 6774 5894 PMC3292304__F4 Gene functional association networks for selected pathways in p53 dataset 355 317 356 7124 10971 596 842 694 836 54205 1616 7832 3315 3316 10200 10198 6732 6693 9261 10199 2810 208 572 207 604 638 4170 573 581 598 3479 3562 22916 60 PMC3292751__F3 Regulation of mammalian mitophagy 55669 9927 55486 7416 4976 PMC3293036__F1 The Wnt signaling pathway in cancer cells 4040 4041 7249 6009 2932 7248 324 2475 PMC3293992__F11 Suppression of the NFKB Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity 54106 51311 51284 51135 7189 23118 10454 3661 3569 5743 7097 4615 7099 PMC3294420__F2 Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links 208 3667 8660 1431 4018 7099 22926 948 4023 PMC3296080__F1 Interactions between insulin-like growth factor-1 receptor (IGF-1R), insulin receptor (IR), and epidermal growth factor receptor (EGFR) signaling pathways 1956 3480 3482 2885 5728 5163 5164 999 2002 572 2475 PMC3297025__F1 IL-1 signaling leads to actin stress fiber formation 6010 7189 4615 3656 3654 51135 PMC3297025__F2 BTB restructuring and spermiation are coordinated by IL-1A during spermatogenesis 3586 2059 3654 51135 4615 PMC3298518__F2 Pathogenesis of neurodegenerative diseases is significantly associated with oxidative stress 9817 6651 4094 847 1728 PMC3298572__F7 Model for HuR NEDDylation 6240 6241 4738 4193 PMC3299342__F3 Signaling by PERK, IRE1, and ATF6 22926 468 83939 7494 7186 PMC3302314__F1 Signaling cascade following TLR2/TLR4, TLR7/TLR8, and TLR3 activation with envelope glycoprotein, ssRNA, and dsRNA, respectively 7097 7099 10333 7098 4615 114609 7187 7189 51135 51311 51284 23118 257397 5132 3665 3661 PMC3303591__F1 Stimulation of PI-3K/Akt signaling pathway after activation of IR/IGF-1R mediates insulin neuroprotection against damaging conditions 2932 2876 84890 PMC3308137__F2 miRNAs that promote or inhibit tumorigenesis provide diverse functions within oncogenic and tumor suppressor signaling pathways 4609 29775 996 3845 10252 10253 389421 894 9134 5728 PMC3308892__F4 ER stress-associated miR-346 induction 7494 100187761 6890 PMC3311515__F1 Scheme for the intracellular renal RAS on the nuclear membrane 1636 59272 367 PMC3316974__F1 AKT-mTOR signaling pathway showing rapamycin inhibition sites in astrocytomas 5728 7249 7248 2475 PMC3317641__F7 Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes 2935 4616 2280 5329 6662 23406 7292 11072 9180 4613 6891 2296 267 440 2810 PMC3318588__F8 Subnetwork of functional interactions of ESRP-target networks 493 9815 392 4646 10919 2050 9693 2990 10413 11146 PMC3318612__F8 Summary model of rAdV-sensing cascades in RAW 264.7 cell line 3661 9447 51428 11201 3665 54106 4615 PMC3321808__F4 Differential regulation of genes in the IL-10 pathway in neonates and school-age children with septic shock versus age-matched controls 3929 7297 9021 6774 2002 6667 7124 7189 1152 PMC3322146__F8 Role of miR-148a in Hepatitis B Associated Hepatocellular Carcinoma 406940 5728 1499 PMC3322338__F1 Hypothetical model for neuroimmune-related actions of miRNAs in brain of human alcoholics (e.g., in microglia) 7099 7852 4615 51135 3656 3654 9021 7189 407047 PMC3323898__F5 Graphical representation of the known connections between the Wnt/Beta-catenin pathway and the Notch1 signaling pathways, according to the knowledge of the current literature 4851 85409 6446 4734 8650 4193 324 1499 3265 2272 595 23493 51176 4316 441478 4323 4609 PMC3324906__F1 Pivotal role of E-cadherin, Beta-catenin, and transforming growth factor B (TGFB) and Wnt signaling pathways in an epithelial-mesenchymal transition (EMT) program 4087 4088 2932 4089 324 999 PMC3324922__F3 ALDH1A1 pathway 8326 10023 999 51176 1499 3728 2932 9627 1856 367 4929 7054 4091 2353 3745 6531 6571 5309 1813 PMC3324922__F4 NOS3 pathway 90952 6578 81 88 10365 3320 1785 7057 4846 80781 2022 3991 857 3551 1997 8743 551 2624 2932 7054 PMC3325426__F1 The miRNA biosynthesis pathway from the nucleus to the cytosol 29102 57510 23405 PMC3328674__F1 Exercise-stimulated glucose uptake in skeletal muscle 2475 5163 5879 23216 5468 4712 4899 PMC3328790__F1 TGFB signaling pathway and its integration with other major pathways that is likely to be involved in the pathogenesis of cardiovascular diseases in elderly patients 4087 4088 4089 7048 7046 860 7049 PMC3328827__F2 Beyond inactivation of the MEN1 gene, additional mutations in other genes may be responsible for acceleration of tumor growth, thus involving a process of multistep tumorigenesis 5728 5894 2475 1499 2353 3725 595 4609 PMC3334867__F5 Inborn Errors of Human JAKs and STATs 3976 5008 1270 1178 6774 8651 6772 9021 3458 PMC3335800__F8 MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells 3553 2353 3725 6908 5999 PMC3335841__F2 Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation 7699 990 140 8320 26762 399 PMC3335841__F3 Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation 8904 25825 409 29116 23062 57817 9146 81618 6653 650 351 4074 523 374868 3558 51744 5425 23308 7073 10714 4968 58528 5069 4093 PMC3336023__F3 Chronic alcohol exposure alters gene expression in HepG2 cells 9180 8717 3717 7186 2475 2157 7276 197 350 183 3263 53918 325 1401 1356 2243 259 7939 2019 7450 2147 3273 PMC3337844__F1 Autophagic proteins 857 355 8772 PMC3341446__F1 Illustration of the PI3K pathway signaling pathway 5728 5163 2309 7249 7248 PMC3343040__F6 Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease 2280 3043 376497 2180 6507 84660 6942 51 57104 8204 50848 6609 206358 3146 134429 3991 6648 2690 5660 2241 3280 1545 6770 4023 6382 3931 3156 1509 1593 3638 2100 9516 2099 6778 22937 2 712 2149 4313 25800 7076 53827 1595 6721 6890 3263 10682 6387 6775 3109 2212 7108 81 309 3417 27314 3108 5118 10519 7263 10553 4199 10135 80824 2806 5699 5159 PMC3344210__F4 The effects of curcumin on the TNFA receptor and its downstream signaling pathway 7124 6654 79629 7186 3606 PMC3346695__F2 Cell signaling pathways involved in ischemic postconditioning 5728 5163 572 581 2932 355 PMC3347452__F7 Proposed model of SubAB-induced PERK-mediated apoptosis signaling pathway in HeLa cells 581 83939 468 PMC3349255__F7 Schematic diagram of a cross-regulation network between FOXA1 and the ErbB2 signaling pathway in ER-negative breast cancer 2064 5058 5971 2353 1385 3169 7090 PMC3351290__F10 TRPC1 channel is a major regulator of EGFR signaling 1950 1956 5163 7220 6786 595 896 PMC3353386__F5 NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways 3133 6891 3105 5699 1520 3437 3659 4778 978 PMC3354586__F3 Ingenuity pathway analysis (IPA) identified critical expression networks containing genes that are significantly correlated with the extent of necrosis in The Cancer Genome Atlas (TCGA) glioblastoma (GBM) samples from all subclasses (A and B) 6774 6036 6035 23210 5329 7538 9332 1051 7128 6515 283455 4864 6279 3684 5971 PMC3355968__F2 Regulation of Mcl-1 and Snail by AKT, ERK, and IKK signaling pathway 2932 5300 1447 PMC3356061__F2 Molecular pathway of activation of autophagy 2475 8408 9776 60673 7405 55626 PMC3356354__F8 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes 3929 929 114609 4615 10454 6101 2475 7124 958 7099 PMC3356574__F3 The signaling pathways regulating radiation-induced bystander effects through expression and secretion of soluble biologically active factors 7124 90865 3569 472 3486 3479 6761 3480 51176 3717 6774 4513 PMC3356707__F1 Canonical WNT signaling pathway 9350 81839 4040 4041 324 1499 57680 64321 51701 PMC3357464__F3 Scaffolds can organize pleiotropic kinases into stimulus-specific signaling modules to direct them to one specific pathway 7186 23118 257397 6416 PMC3358533__F5 PPARA signaling canonical pathway in chronic arsenic-exposed lung epithelial cells 5465 7189 7186 3326 5467 54788 10049 3064 10370 8431 4513 PMC3361678__F1 Many host factors are involved at each step of the HCV life cycle, which starts with virus binding to its specific receptors (CD81, CLDN1, OCLN, and SR-BI) 975 1956 1969 8694 5007 348 5297 8729 9218 9217 PMC3361682__F2 UCB interaction with neural plasma membrane (A) and pathways by which UCB may affect neuronal function (B) 735 581 7186 637 PMC3364461__F4 PI3K/mTOR signaling at the FSHR 2492 5728 2932 7249 6009 2475 6194 PMC3367558__F1 Wnt signaling pathways 22943 4131 324 2932 1499 387 5879 PMC3367558__F2 Wnt signaling at vertebrate neuromuscular junctions 7473 5879 324 1499 6010 5058 4593 PMC3367714__F1 ATM/ATR DNA-damage response pathway 84126 472 545 7465 1869 PMC3376493__F4 A Human Homeotic Transformation Resulting from Mutations in PLCB4 and GNAI3 Causes Auriculocondylar Syndrome 1906 1909 2773 5332 5331 1750 1749 PMC3376640__F6 Proposed Model of Psoriasis Pathogenesis in the Presence of Psoriasis-Specific CARD14 AlterationsAfter an inflammatory trigger, alterations in CARD14 induce activation of NF-kB 79092 7186 7187 10318 50616 6364 7124 26525 PMC3376961__F1 Annexin A2 pathway in pancreatic cancer invasion and metastasis 302 6010 999 PMC3381956__F1 Signaling pathways and their targeted therapies in NSCLC 3082 1950 1956 3815 5728 8772 6714 7249 7248 2475 6794 3091 PMC3382265__F1 Molecular network of protein degradation, amino acid metabolism, and behavior for NC-treated cells in comparison with TC extract-treated cells 1356 79890 357 7533 274 2549 9846 10376 2885 57175 7532 2641 203068 1399 91179 1794 60 3433 7184 811 PMC3383335__F1 SnoN Signaling in Proliferating Cells and Postmitotic Neurons 3622 8554 999 PMC3386543__F7 Schematic of C/EBP A/B functions in GCs 635 5724 8829 1950 1583 860 6770 PMC3387006__F8 miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes 7048 7046 4087 4089 4088 1875 1030 1026 983 1019 PMC3387019__F7 Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss 1636 59272 4314 PMC3387494__F3 The regulatory network of EZH2 898 1017 2146 6418 PMC3387579__F1 De novo DAG/TAG synthesis (Kennedy pathway) 1605 4018 355 PMC3388509__F2 Inflammasomes and Intestinal Tumorigenesis 6772 6774 4513 PMC3392028__F1 Transcription factors and signaling involved in the osteoblast differentiation pathway 4488 3206 4208 3199 57154 4091 324 10682 3280 2113 4090 4086 23314 51176 4088 6772 23462 860 468 9242 1499 3549 PMC3393821__F2 Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: Preliminary findings 3600 7124 7132 3455 59067 50615 3454 3716 3718 7186 8737 6774 4794 5971 4791 596 PMC3394947__F1 The proteins involved in the different pathways related to eicosanoid biosynthesis 5465 8309 5468 8310 7055 9536 4056 4259 196 64174 PMC3397898__F6 Signaling pathways that regulate cAMP-mediated WPB exocytosis 5900 5898 5337 PMC3402799__F2 Networks generated by Ingenuity Pathway Analysis of the expression signature 10814 80331 9810 9899 5605 6529 10060 3772 3064 6843 51046 3569 9217 6536 84258 1182 290 432 7124 65010 6568 5174 10004 9748 6583 10158 6755 5732 5734 656 6752 91 25 1325 1588 6753 3304 4087 268 55577 200186 11245 1602 3656 9414 10971 4093 8065 1612 8878 2570 51676 PMC3403008__F3 Regulation of TLS in replication-associated ICL repair 22909 199990 51455 5111 56852 PMC3405917__F4 EMT in fibrosis 6935 9839 999 1000 PMC3407377__F3 TGFB signaling via TAK1 pathway: Role in kidney fibrosis 4087 4088 10454 4089 1386 PMC3407651__F1 STAT3 signalling pathway in ALK+ ALCL 3718 150365 27040 9021 29851 3091 3559 238 6774 PMC3407651__F3 PI3K/Akt signalling pathway in ALK+ ALCL 6469 6608 6194 5728 2475 993 894 238 PMC3410437__F2 KEGG pathway of the renin-angiotensin system 1636 4311 59272 5476 57486 1359 186 183 5972 1511 2028 290 4012 PMC3410583__F3 Pathways of autophagy induction by hypoxia and mutant RAS 3091 664 665 9474 10533 2475 468 PMC3414724__F4 Alterations in the PI3K pathway in malignant B cells 613 930 5266 5728 6850 PMC3414811__F2 Two branches of the unfolded protein response 22926 7494 7186 468 83939 596 PMC3415084__F2 Impact of placental insufficiency on endocrine responsiveness in fetal myoblasts and myofibers 8660 3667 207 208 PMC3415277__F6 Identification of multiple disrupted components in a biological pathway 1950 7038 7039 4582 6464 2885 3845 5335 6655 83593 11186 6237 4485 3708 5163 208 5578 5894 5604 842 572 1846 5594 595 4609 1956 2064 PMC3417337__F1 Platinum drug action pathway 1244 1317 5243 9429 1728 538 4353 540 2950 5887 7157 2073 7508 7507 595 902 2074 2067 4193 6240 2072 PMC3418550__F1 Pathways of SMX metabolism, bio-activation and detoxification, and pathway of GSH biosynthesis 2937 9 10 4353 PMC3419137__F3 Targets of the tumor suppressor gene miR-200 in regulation of the epithelial-mesenchymal transition in cancer 26998 8038 652 3959 8751 5054 54749 170689 1471 4811 5476 1000 1512 871 10417 1514 1893 1522 2192 8836 2335 6678 64129 PMC3419258__F6 Proposed model of FGF23 signaling in proximal tubular cells 6446 8074 5741 2260 PMC3420349__F1 P53 signaling pathway: In normal conditions (black arrows), p53 is maintained at very low levels 472 545 4193 581 5111 PMC3421049__F1 Genomic Variation and Neurohormonal Intervention in Heart Failure 2784 1636 1585 PMC3421232__F5 Network of 25 target genes and their interactive genes involved in regulating apoptosis and autophagy 2475 2194 8772 843 100506742 572 841 836 8717 637 22863 3656 842 30849 5289 5290 PMC3422444__F2 AIDing antibody diversity by error-prone mismatch repair 4436 2956 4292 5395 9156 9025 3014 PMC3423475__F9 Animal oral and veg1 ectodermal GRN for sea urchin embryogenesis 4838 145258 7474 PMC3424007__F1 Biological association network (BAN) of differentially expressed genes in common between CA and ICC 7124 56655 27020 2690 2057 9612 2056 5898 3717 9361 7066 3630 4352 85480 PMC3425429__F1 Working model depicting some of the multiple signaling pathways that have been reported to modulate cell-cycle activation and/or proliferation in rodent Beta-cells 3082 5728 5618 3667 5163 121278 7166 6009 2308 PMC3425523__F4 Genes known to cause kidney cancer and their relationship with the mammalian target of rapamycin signaling pathway 3082 96459 57600 7249 201163 7248 6009 2271 7428 PMC3426484__F1 Asparagine N-Glycosylation pathway 79868 85365 440138 56052 1798 22845 57171 29926 5372 29925 5373 6675 5238 4351 91869 8818 54344 84920 79796 79087 29929 10195 51046 4122 4247 11282 4121 79694 338596 10905 23193 4124 8128 4245 4248 80267 57134 6484 10956 PMC3427792__F1 Akt isoforms and glucose homeostasis - the leptin connection 3479 5163 7249 7248 143686 6009 1977 PMC3428775__F3 Model depicting effects of Wnt-stabilized Beta-catenin through Tcf proteins in mESCs 6657 6929 79923 PMC3429047__F5 Simplified illustration of the canonical Wnt signaling pathway 324 847 4040 4041 PMC3429540__F1 Emerging role of autophagy in kidney function, diseases and aging 5594 5595 207 10670 64121 7249 7248 6009 2280 1978 PMC3429544__F8 Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition 26284 7157 55332 PMC3430207__F3 Molecular relational network of genes modulated by BaP in lung tissues enriched for cancer function using IPA for all three doses with p53 at the central node 58480 1675 3309 4855 94241 900 9518 6369 1026 581 595 3934 4050 9590 3914 9173 3553 5054 6240 5366 4254 6288 3672 4193 5156 3485 598 1969 1264 10516 72 1410 5329 9448 80310 3150 7168 4314 8743 961 51196 64065 6469 4609 8288 4345 1634 5970 10769 2152 29760 51330 627 4005 285 5583 3488 1030 4056 3630 PMC3431075__F1 NFKB members and NFKB signaling 613 958 5970 5971 PMC3432834__F2 Two NFKB activation pathways induced by RANK, CD40, and LtB R signaling 958 4055 7189 7187 7186 5970 5971 PMC3434350__F1 Translational impact of the mTOR signaling pathway 6194 1981 1977 960 7431 9112 PMC3438665__F1 p53-dependent and -independent therapeutic strategies for cancer cells 145270 331 2475 4193 PMC3439829__F4 Diverse cohesinopathy phenotypes 114799 157570 23047 23244 23063 25836 55869 23383 PMC3444692__F2 ATF-2 is a nuclear target of p38/Jun N-terminal protein kinase (JNK) 472 1386 3553 4089 4086 4088 PMC3454471__F5 Redox regulation of the Nrf2–ARE pathway 9817 8452 571 4094 PMC3457170__F4 JAK/STAT signaling pathway is targeted by RVFV NSs protein at different levels 50616 23162 10379 9282 3448 6041 6035 1965 440275 3455 PMC3458271__F2 Two proposed models of ephrin-B reverse signaling in palatal EMT based on current evidence 7043 2475 6774 PMC3458425__F6 Docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and 16O/18O labeling 7528 9899 1958 1385 1020 PMC3458933__F7 Schematic overview of the results from the present study indicating WNT-5A secretion from astrocytes and the WNT-5A-induced signaling pathway towards ERK1/2 regulating distinct aspects of the proinflammatory transformation of microglia 7474 4322 4318 PMC3460211__F3 Formaldehyde-responsive miRNAs predicted to modulate MAM-associated genes in the brains of Mgmt−/− mice 2043 10628 817 5981 132789 2915 4922 PMC3460412__F1 Activation of p38 MAPK downstrem of TNFR1 7124 8717 7186 7188 PMC3460930__F1 Lovastatin Induces Multiple Stress Pathways 1956 467 83939 595 7249 468 2475 PMC3463457__F1 Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells 207 1026 1021 5594 1027 2002 2308 5542 1869 2475 PMC3466241__F7 Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway 9817 8452 4094 PMC3466981__F3 The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis 10763 672 472 675 5888 PMC3469060__F6 Putative mechanisms responsible for UPR activation by CD147 in human HCC cells 3091 7018 7528 22926 PMC3474186__F3 Apoptotic signaling through tumor necrosis factor superfamily receptor 6 (Fas) and tumor necrosis factor receptor (TNFR) 7186 8717 355 8772 637 836 842 317 3553 PMC3474235__F2 Scheme of the various interactions between GSTs and MAPK implicated in stress-signaling pathway (adapted from ) 7186 367 2938 2941 PMC3478886__F1 Prognostic Value of Cell-Cycle Regulation Biomarkers in Bladder Cancer 1029 595 1017 1019 4193 2064 1956 PMC3484421__F2 The PI3K/Akt/mTOR pathway: Ligands binds to the receptor tyrosine kinases like EGFR, IGF1R, Her2, and Ras leads to conformational changes and activates PI3K 1956 3480 5728 4193 6009 2932 2475 572 1977 PMC3484588__F4 Cellular affects of TNFA.Tumour Necrosis Factor alpha (TNFA) is produced by macrophages, lymphocytes, fibroblasts and keratinocyte 7124 7186 637 8717 8772 958 PMC3492937__F5 Stem cell pathways analysis for label-retaining cancer cell (LRCC) 7471 7475 2246 2249 650 652 655 649 2260 1855 1457 2932 4090 4086 1499 6932 51176 79923 6657 9314 8433 894 5925 6387 8549 1840 113878 4311 8456 63973 1558 64321 3866 PMC3492958__F1 Distinct roles for AlphaB hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling 4018 4099 5346 5091 3667 5170 5465 PMC3494185__F7 Hypothetical schematic of the roles of KPNA2 and E2F1 in NSCLC 3838 1869 10926 23210 55388 5422 23649 5395 7358 PMC3499531__F6 Transcriptome Sequencing and Annotation for the Jamaican Fruit Bat (Artibeus jamaicensis) 3621 1470 5595 5881 6395 4133 5880 PMC3499814__F2 RIG-I signaling pathway and inhibition by influenza A viruses (Figure adapted from ) 7706 57506 7189 29110 10010 7187 1386 3661 PMC3500439__F1 Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor Alpha as a Therapeutic Target in Cancer 3479 7248 2475 7528 3565 7481 PMC3506908__F4 Pathway analysis derived by comparison of the relative abundance of metabolites from sera derived from patients with locoregional CRC and liver-only metastases, as determined by GC-MS 1356 225689 55450 5596 11181 165 283455 10913 171392 54756 7032 5375 57118 50639 80381 10462 10981 671 6695 4902 3036 50486 4953 55600 58191 551 27190 PMC3508169__F2 Known relationships between the candidate genes 684 7099 3655 2194 135228 5579 5747 6714 5582 6546 5578 3685 3611 102 5791 3643 8660 8471 PMC3510027__F2 Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease 2168 10068 54840 920 3081 5519 4288 2908 9282 824 4055 55647 2063 4306 56616 1616 3164 3973 3064 836 23621 2904 351 26119 8754 5251 PMC3510027__F3 Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease 10232 5290 207 5063 6237 5347 596 5300 5894 2342 2339 5519 5528 PMC3512574__F5 TGFB in Cancer 2290 1874 4609 4089 4088 1017 1019 4086 3397 467 PMC3514635__F4 Intracellular trafficking proteins involved in CMT neuropathy 10397 1959 5376 79628 8898 1785 121512 9896 54332 9927 4359 PMC3514907__F3 GeneGo “Cell Adhesion_ECM remodeling” pathway map 7076 7077 7078 4312 5327 5340 4316 5270 5328 1950 3481 3910 3479 4324 4325 5329 960 1956 PMC3515668__F1 Schematic representation of the potential disruption of the hepatic GHR-JAK2-STAT5b signal transduction pathway by TCDD 2690 196 3717 9021 PMC3516764__F9 Model for the involvement of the RA in neuronal differentiation 2171 5915 5163 84962 23411 PMC3517549__F1 The Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses 54472 4615 7097 114609 51135 23118 7189 10333 7099 7100 51311 51284 3665 54106 3661 7187 7098 29110 PMC3518132__F8 Alkylphospholipid (ODPC)-induced raft-based inhibition of cell signaling 7462 2885 5728 5163 27040 PMC3518628__F1 Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS 324 84720 1499 PMC3519901__F7 Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection 338376 8772 8737 10379 10010 2994 3661 3725 PMC3520616__F1 Upstream events in BCR signaling 613 6850 4067 5336 695 PMC3520888__F1 Escorting Ras 9610 27183 79643 1956 PMC3521387__F9 ILOCi detected genes from T1D and their maps in 'type I diabetes mellitus' pathway 3118 3119 3122 3630 5799 940 1363 920 3458 5551 7124 PMC3526895__F9 Schematic model of the signaling pathway activated by redox/metabolic imbalance and its possible positive impact on human lifespan 10891 4780 2729 6648 PMC3527322__F1 Amniotic fluid stem cells to study mTOR signaling in differentiation 3667 5163 64223 2475 64798 253260 7248 7249 6446 6009 8408 9776 3091 2887 PMC3527976__F2 Two rapamycin-sensitive myogenic mTOR signaling pathways 2475 3667 5337 9759 PMC3529568__F1 TGFB latency, activation and signal transduction 7939 4087 4088 387 5045 4089 PMC3529804__F3 Novel Directions for Diabetes Mellitus Drug Discovery 2056 23411 2475 PMC3531707__F3 PERK signaling under virus attack 1998 468 7494 PMC3531794__F1 Impact of IL-27 on lymphocyte signaling pathways 10148 3716 3717 7297 2625 6772 6774 196 2833 PMC3535427__F1 Targeting 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) for colorectal cancer prevention and treatment 4015 4512 4049 4050 PMC3536145__F7 GXM-mediated inhibition of LPS-induced signal 7099 4615 3603 PMC3539736__F3 PI3K Signaling in B and T Lymphocytes: New Developments and Therapeutic Advances 920 1235 29851 5163 6009 10365 50943 3586 PMC3539739__F1 Oncogenic Transcription Factors: Cornerstones of Inflammation-Linked Pancreatic Carcinogenesis 7124 6608 1950 1956 51684 6774 595 896 1021 1019 3383 7852 7412 3082 331 6469 81671 PMC3539824__F2 Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders 8829 2534 2932 1020 PMC3539910__F2 Carcinogenesis of colorectal cancer cells and role of different miRNAs in cancer pathways 1499 324 1630 4087 4089 581 5728 595 572 1956 5900 842 836 PMC3540089__F1 PORPHOBILINOGEN DEAMINASE Deficiency Alters Vegetative and Reproductive Development and Causes Lesions in Arabidopsis 2973 210 7390 7389 130749 PMC3543845__F2 Top network, “DNA Replication, Recombination, and Repair, Gene Expression, Cancer”, formed by genes exhibiting altered expression in MLT-pretreated MCF-7 cells upon MMS exposure relative to untreated MMS-exposed cells 9133 5423 7486 9588 389524 395 58485 57097 10615 80254 80344 1380 284486 57508 140735 25966 9422 390980 PMC3553295__F3 Cocaine and Withdrawal on the Mouse Nucleus Accumbens Transcriptome 5909 5908 1387 PMC3553975__F6 Subnetworks identified from (a) Wang et al 7046 7048 960 9133 7327 9459 596 64750 7337 7161 1026 51053 367 5371 1017 890 5425 5241 991 1616 5111 7157 4176 8841 5933 26135 9055 PMC3557433__F1 Effector intercrossing network under physiological condition 23411 7351 7038 8660 581 57447 389692 7345 PMC3560328__F4 DNA interstrand crosslink repair and cancer 80198 146956 22909 PMC3561376__F5 Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways 4318 133 1435 3456 8743 3600 3558 4070 6916 3559 836 9698 581 8772 64112 596 4616 7357 1460 6772 841 1026 7015 50943 2113 4609 6777 6304 10912 6621 PMC3561517__F8 Overview of the recruitment and modification of PCNA and Pol D by RNF8 involving different DNA damage pathways 9025 5111 56852 PMC3561798__F6 Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis 55744 6778 196 3566 3716 3718 5770 405 10344 388697 2312 3713 PMC3563505__F6 Functional partners of RB1 protein through STRING database 5928 3065 1871 7027 1870 1869 5925 1019 4193 595 1017 PMC3572738__F4 Cellular iron balance 8556 26234 212 6500 8454 PMC3574814__F1 MYC target genes in the polyamine pathway 4609 262 56648 6723 PMC3575850__F8 Hypothetical model for functional redundancy of Rad18 and NHEJ in responding to oxidative DNA damage during G1 6741 56852 353497 5111 PMC3577828__F6 Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance 3667 7249 7248 6009 PMC3577986__F1 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy 3065 4067 80274 596 6403 3172 867 3710 5133 5966 717 6775 1773 7292 10666 5468 2064 7297 2214 26191 7184 11277 8576 3558 3586 640 7045 PMC3578734__F1 Scheme of CML hematopoietic stem cell signaling pathways in which predicted targets of microRNAs associated with CML are involved 572 4193 9846 2885 4609 7046 4089 867 693149 PMC3579404__F1 Conserved Wnt pathway branches and components 4040 4041 4920 6259 324 28996 998 6010 6929 51176 PMC3580541__F5 TRAF6 and TRAF2/5 signaling pathways 367 7189 7186 7188 6955 3550 PMC3581799__F5 Cell-to-cell signaling network generated by ingenuity pathway analysis of differentially expressed genes: Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line) 51083 2162 6349 414062 6354 3553 2921 1230 6382 3579 948 6556 54210 5788 2212 3687 290 3689 2207 26253 6402 2209 7133 2204 338442 1441 4792 4843 6280 597 23601 PMC3585436__F2 Simplified scheme showing the critical role of Class IA PI3Ks in multiple cellular functions 5163 5728 6009 2932 572 7249 7248 PMC3585436__F3 p110D PI3K pathway in B cells 613 3565 7099 929 930 958 4067 6850 695 5336 10563 643 PMC3589091__F1 Pathways of PI5P synthesis and turnover 5289 200576 9896 5266 PMC3589124__F7 FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage 2309 472 28996 581 PMC3589762__F2 Pathways regulating intestinal sterol absorption and homeostasis 64240 948 29881 39 4547 335 19 PMC3590129__F7 Differential Expression of miR-145 in Children with Kawasaki Disease 7046 7048 4087 4088 4089 3845 387 PMC3591455__F5 Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 Cells 930 4067 29760 2885 6850 695 PMC3592471__F8 Functionally related pathways of aberrantly methylated and differentially expressed genes in immortalized MEFs 25928 2005 161253 5600 55090 1356 6667 27075 401 PMC3593299__F1 Ghrelin neuroprotective pathways in Parkinson’s disease 7351 2693 7019 65018 120892 2475 8408 10533 PMC3593794__F3 PAFAH1B1 (platelet-activating factor acetylhydrolase 1 regulatory subnuit 1, formerly known as LIS1)-binding partners 81565 54820 1641 10726 5048 5049 5050 6249 1600 8826 998 5879 PMC3593794__F6 CDK5 phosphorylation substrates during neuronal migration 81565 5747 1641 1020 8851 1027 387 3984 1072 PMC3594247__F1 Hippo on the move 60485 4485 9113 26524 PMC3594312__F5 Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines 9572 3659 8767 196 3652 7186 330 10758 7189 658 5054 8795 54205 8651 5329 1959 6507 9314 351 3727 7422 468 PMC3594520__F1 TLR3 immunity to infection in mice and humans 7098 9865 7187 23118 8717 29110 10010 255520 2549 1654 6737 3661 PMC3594740__F1 TLR signaling 7099 114609 4118 4615 3656 51135 7189 23118 257397 10454 7187 3661 PMC3596529__F1 Intrinsic control of axon regeneration 5163 5164 5728 2475 7249 PMC3601079__F3 Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin/+ Mice through Transcriptomic and Metabolomic Reprogramming 1630 4087 324 4089 2932 1499 387569 572 842 3725 2353 5900 836 4088 7046 581 PMC3601164__F2 Links between Toll-like receptor 4 and breast cancer 7099 4615 3654 7189 PMC3603280__F1 SLC41 family of MgtE-like magnesium transporters 84061 254428 54822 23269 5335 57380 84102 PMC3607076__F3 ATM controls cellular survival in response to DNA damage through multiple pathways 472 4193 637 PMC3607103__F3 Recognition of nucleic acids by innate immune cells triggers cytokine production 613 9447 57506 54106 51284 51428 4615 3665 3663 PMC3607621__F1 Dark face of AMPK as an essential tumor promoter 10645 2539 47 3417 4199 355 PMC3608206__F4 Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate 3976 6469 1950 6774 6657 79923 55636 6658 6664 PMC3612022__F6 Proposed synergistic pathway to mitotic cell death in cells treated with a combination of paclitaxel and gefitinib or the PLK1 inhibitor BI2536 7465 995 3925 5347 PMC3612035__F7 Non-Canonical CRL4A/4BCDT2 Interacts with RAD18 to Modulate Post Replication Repair and Cell Survival 56852 6596 81620 472 545 5111 PMC3612515__F3 Graphical representation of Ingenuity Pathway Analysis results showing considerable overlap of the significantpredictor genes in the significant biologic pathways 57584 10413 7004 9149 51375 7532 1874 7534 2176 673 7476 3845 23281 1051 2908 5530 54518 4312 8996 2247 7157 8451 3685 2308 10135 3339 301 7042 53354 7298 PMC3613593__F1 Hedgehog pathway 6608 51715 2736 2737 11127 2619 91653 2735 PMC3613856__F7 Association of Luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies 1977 55802 167227 PMC3615463__F1 Phosphoinositide 3-Kinase Inhibition in Chronic Lymphocytic Leukemia 613 695 4067 6850 2475 6722 5728 PMC3615616__F1 Self-renewal and differentiation of gastric stem cells 6469 6648 5744 375 3992 53841 3485 805 56287 4586 7031 94234 7032 5225 4588 1950 PMC3617098__F1 Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 6741 142 5423 PMC3618249__F3 combination drug simulation result on T2D model 5468 8660 3643 181 5781 3265 2885 2888 50964 PMC3618522__F1 Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment 2171 5163 5914 5915 595 PMC3618522__F2 Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment 5914 5915 142 PMC3622753__F1 Intracellular S100B on cell proliferation, differentiation, survival and motility 6285 595 1019 1950 6714 7204 5163 5164 387 998 PMC3624298__F1 Downregulation of human NK cell-mediated cytotoxicity pathway genes in response to Gal-9 3811 3106 3812 3133 3384 3383 4277 100507436 80328 80329 79465 962 PMC3628025__F7 Proposed model suggesting that TGFB increases COX-2 levels and PGE2 secretion in prostate cancer cells and both TGFB and PGE2 activate PI3K/AKT/mTOR signaling pathway 1950 1956 4087 4088 2475 PMC3630242__F1 Leptin and adiponectin activate signaling components that integrate PI3K/Akt, RAS/MAPK, and pAMPK/mTor pathways 1401 79602 51094 26060 3717 3667 8660 9021 5728 5465 7157 595 7249 3725 2353 27068 PMC3630382__F10 "Cell Death and Survival, Cell Cycle, Cell-to-Cell Signaling and Interaction, Cellular Movement" Network 785 84920 546 3418 55325 801 9782 3857 25940 3850 8735 253650 51121 57644 25980 28974 84295 57693 196463 PMC3631253__F4 A Protein Prioritization Approach Tailored for the FA/BRCA Pathway 8317 7531 10734 10926 23626 23397 7514 898 899 11144 4193 10592 220296 6794 3832 3400 23310 11130 699 4999 9055 11190 55743 9735 4752 PMC3632609__F1 Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain 169355 125061 8564 8942 130013 23475 PMC3632646__F2 Regulation of GLI1 the isoforms by the canonical and noncanonical pathways 6469 2735 6608 4089 4088 51684 2932 5156 4193 10284 PMC3632731__F1 Network 1 (antigen presentation, cell-mediated immune response, and humoral immune response) generated by pathway analysis of the hot list 114990 2026 173 80781 5340 4151 334 2 9746 351 3502 545 4026 721 720 729 717 PMC3633528__F1 Cytokine signaling cascades that influence tropoelastin transcription 7040 1839 1950 7039 1017 1019 10682 3725 6667 PMC3636885__F8 STAT3-mediated coincidence detection regulates a noncanonical pathway of IEG induction 1950 1956 5163 5164 2931 2932 6774 1958 PMC3637951__F7 FOXM1’s role in thyroid cancer 2305 891 9212 6502 5347 5328 PMC3638063__F1 MTOR signaling pathway 2475 5728 64223 253260 5163 64798 6446 7249 7248 6009 2887 1977 PMC3638125__F2 Intracellular signaling pathways of GLP-1R in the pancreatic Beta-cell 1956 468 2308 595 PMC3638621__F11 The pathway map of urea cycle 2593 384 367 162417 5009 PMC3641131__F6 Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains Beta-Cell Phenotype in Human Islets 3479 3667 8660 25874 51660 7249 7248 1499 2475 PMC3642686__F4 Schematic description of the MSR 7186 83939 7494 3661 3665 3663 468 PMC3645738__F4 Hypothetical time course of the unfolded protein response in mammals 7186 22926 4924 7466 83939 468 PMC3648157__F7 Dysregulation of cellular networks in the presence of PAN RNA expression 7031 91947 5739 5027 4854 4907 54210 7262 4758 1959 1030 1847 467 5087 5624 6367 6351 3784 8771 80328 8809 4804 7133 23495 613 64127 3872 114548 64170 9531 1999 10537 2354 8013 3665 6775 PMC3648520__F1 Roles of DNA Helicases in the Mediation and Regulation of Homologous Recombination 5888 641 675 5893 84893 118027463 3552 80010 PMC3649699__F2 Cerebral ischemia-reperfusion activates two major signaling pathways which exert an effect on NOD 596 2155 3603 PMC3651307__F1 Toll-like Receptor (TLR) Signaling Pathways 7096 7097 10333 51284 7099 51311 54106 7100 54472 114609 4615 7098 51135 353376 3654 148022 7189 7187 9641 3661 3665 PMC3652374__F1 Insulin signalling attenuates cAMP-mediated lipolysis at multiple steps in adipocytes 4099 7038 3643 3667 2887 5346 8654 5140 PMC3652374__F4 PPARG as a key regulator of lipogenesis in adipocytes and hypothetical major target for inhibitors of insulin-stimulated lipogenesis in obesity 3458 3553 355 PMC3653416__F2 Autophagy in alcohol-induced liver diseases 1571 2475 8408 3916 10533 PMC3655322__F3 Diagram showing some of the upstream elements of the proposed Hippo pathway 999 1499 4485 558 9113 26524 PMC3657316__F3 Ciliary signaling pathways implicated in control of cell proliferation 3717 5156 1017 3398 PMC3657461__F3 PI3K/AKT signaling in prostate cancer 1000 5728 6347 367 2289 PMC3661940__F1 Intrinsic somatodendritic and presynaptic modulation of action potential (AP) firing and transmitter release in 5-HT neurons 8484 4987 885 8811 1524 PMC3662247__F6 PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity 3146 7189 3661 7099 4615 114609 929 PMC3663490__F6 Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer 4361 2175 2189 57697 2176 2178 2177 4436 3014 595 472 641 675 5925 PMC3663800__F7 New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer 5156 5159 1956 2261 5335 5336 6464 53358 399694 25759 5578 5581 5579 5588 5582 5590 5580 5584 5583 2885 6654 6655 8877 56848 11186 5894 1612 5604 5605 23604 1613 5594 23530 PMC3663800__F8 New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer 2261 1612 595 4193 1019 1871 1870 1869 2064 1956 1950 PMC3666377__F3 Functional Beta-cells respond to increasing glucose levels by increasing insulin secretion 847 2645 6928 6927 4760 50943 9451 8462 3832 5078 3651 169792 256297 222546 PMC3666388__F5 Adult haemangioblast genetic regulatory network 2120 7422 2313 2624 2116 2324 2004 51162 2321 83595 PMC3668831__F1 Iron regulation by hepcidin 654 148738 3077 4089 6774 3717 4086 PMC3670240__F1 Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells 3976 3977 2885 6774 81603 2932 6926 79923 117854 4609 PMC3670858__F1 Acetylsalicylic acid metabolic pathway 348158 95 6295 1559 PMC3673784__F1 Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition 9350 7482 11197 7976 6104 1857 2932 8658 80351 1457 4087 4088 6925 332 3725 PMC3673972__F10 Antioxidant and Anti-Inflammatory Effects in RAW264.7 Macrophages of Malvidin, a Major Red Wine Polyphenol 929 7099 4615 29110 7189 5728 2932 114609 PMC3674189__F7 Estrogen receptor B ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis 3479 627 5728 PMC3674720__F1 The insulin-signaling pathway 3667 57761 2534 1398 2475 572 PMC3675677__F1 Insulin-like growth factor type I (IGF-1R) signaling axis 5163 3667 3480 5728 7249 7248 2887 6009 2475 PMC3675900__F2 Eicosanoids in Metabolic Syndrome 948 9415 60481 3992 5226 4050 260431 PMC3676112__F7 Translation regulation of the mTOR signaling pathway and translation process 2475 253260 3091 1975 7248 6009 7249 1977 673 6233 1938 6122 2107 6207 7458 6193 8666 1937 8669 6139 6133 6208 6175 9669 PMC3678929__F2 Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway 3479 3481 5728 3667 2885 7249 7248 572 8178 2475 PMC3679268__F7 GSK-3A Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1-TAB Stabilization and Regulation of Non-Canonical NFKB 10454 2931 5971 PMC3679380__F5 Extranuclear and nontranscriptional effects of RA and vitamin A 5914 64220 6714 3717 PMC3679382__F8 Working model of the FGF21 regulatory pathway under leucine deprivation 83939 468 26291 7350 1734 355 PMC3679547__F1 Canonical pathway analysis 6387 84639 335 7852 64240 949 4481 3949 8740 64241 5340 3156 22808 4322 5781 3569 6774 4018 348 PMC3682694__F1 Roles of molecules explained in this review in signal transduction 2885 5728 545 472 5310 4763 6418 27068 2932 7428 7249 7248 6009 1499 324 2475 PMC3689254__F6 Several flavonoid compounds also target the Fyn/Src signaling pathway 2534 6714 4513 5111 1386 6772 PMC3689841__F1 Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation 126669 2885 2549 9846 5728 5163 PMC3690116__F1 Schematic model of FGF-2 and FGF-18 signaling pathways in articular cartilage and IVD 860 2002 85451 1300 2260 2261 PMC3691915__F8 Regulators of mitochondrial biogenesis and function 7038 4023 948 3667 208 4712 2308 PMC3692130__F1 Graphical representation of Wnt pathway as described in the KEGG repository () 59343 5566 4609 64840 3725 9350 22943 51701 1855 6907 27101 6477 11197 80319 8178 56998 5467 9978 23291 7157 64321 85407 1487 4316 387 11211 57216 23236 PMC3693188__F1 TP53-centered network in CLL: A novel pathogenetic model for chronic lymphocytic leukemia (CLL) showing a pathway of microRNAs and cytogenics that are involved in the development of CLL 4193 472 4170 596 7535 PMC3696549__F10 Reciprocal regulation by TLR4 and TGFB in tumor-initiating stem-like cells 4088 2475 4092 10413 79923 10643 7099 7046 7048 PMC3696796__F5 Schematic depiction of LB-205 effects on NGF stimulated pathways 4803 317 581 PMC3697618__F7 Diagram illustrating the phagocytic signaling pathway initiated by TLR4-linked JAK2 activation during the internalization of B 7099 3929 929 998 3717 PMC3701121__F3 Angiogenesis signaling pathways in epilepsy 7422 7075 6010 6714 842 PMC3702279__F5 Schematic diagram illustrating miR-185 and ATR function in radiation response 5884 11073 84126 545 PMC3702291__F7 Schematic model of signaling pathways in salinomycin-induced cell growth inhibition and apoptosis 1017 324 999 6774 6502 572 595 PMC3706840__F8 PRL-Dependent Tyrosyl Phosphorylated PAK1 and 3D Collagen IV Regulate MMP-1 and MMP-3 Production and Invasion via MAPK Pathways Schematic representation of the proposed working model 3717 5058 4312 4314 4313 PMC3707373__F1 Regulation of Th9-Type Pulmonary Immune Responses. A New Role for COX-2 920 64806 55540 PMC3707951__F4 S100A8 induction in macrophages 6279 7099 4615 7189 7098 7187 3661 10682 6774 PMC3708280__F3 Molecular background of major signaling pathways responsible for proper development of muscles and muscle stem cells in normal tissues and tissues affected by laminopathy 1499 4617 324 2932 4008 3280 23462 652 2475 1950 27068 983 4827 PMC3708595__F4 Mutational Landscape of Adenoid Cystic Carcinoma 6595 8289 6605 546 10847 1387 472 5591 29072 2033 10933 8243 672 7157 64324 23774 7994 284058 29128 7403 23135 51742 9874 63035 54880 221037 4609 4602 27255 54756 4603 4781 2264 3645 23220 93986 55294 5728 3265 4613 26292 55534 9223 23269 4149 9863 5605 PMC3708799__F2 PTEN in Beta-Cell Growth 572 4193 7249 7248 2475 5728 2932 355 PMC3709966__F4 HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis 30968 3028 3030 811 6876 3609 71 6010 4619 230 PMC3712008__F2 Subnetwork representation of protein interactions based on 78 mutated genes in 602 breast cancers - 5728 2898 868 9611 88 9439 1756 3908 546 PMC3712043__F1 Activation of the IRS signaling cascade pathways 100187761 3479 126669 5163 2475 7249 7248 253260 6009 572 331 2002 1977 8408 9706 PMC3712543__F4 Somatic variations in genes encoding proteins of the KEGG “Melanoma” signaling pathway 5154 1950 2260 1956 3845 3265 5447 369 572 PMC3712731__F4 Display of wild-type and disease pathway diagrams 1950 1956 26018 11140 5335 PMC3713536__F2 Anticoagulant and cytoprotective actions of the protein C pathway 100187907 324 387 5879 PMC3716752__F1 Toward understanding the genetics of regulatory T cells in ovarian cancer 5996 50943 941 324 1493 7124 PMC3717793__F1 Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 999 9978 2308 10140 8454 6500 6502 PMC3717794__F2 Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway 57103 27165 581 PMC3720640__F3 Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance 5802 6714 5728 595 PMC3722958__F1 P38 MAPK in the induction of pemphigus vulgaris (PV) 9261 7867 1830 1828 PMC3724215__F1 IGF pathway 3479 3481 3482 3480 3643 6464 2885 5728 572 2475 1978 1977 1975 PMC3724356__F2 Molecular events in cholangiocarcinogenesis 1950 2064 1956 4193 596 PMC3724785__F7 Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1) 1499 22943 324 2932 999 79412 83999 4040 4041 6104 PMC3725690__F6 Working model for the NOX dependence of TNFA production by the liver following I/R injury 5879 27035 5880 PMC3725758__F2 Neurofibromatosis Type 2 Protein, NF2: An uncoventional cell cycle regulator 4771 2475 998 5879 1977 2353 595 PMC3725781__F1 Genetic and molecular control of Osterix in skeletal formation 6662 860 1277 650 3479 7494 PMC3727904__F2 PATHWAYS IN MICROBE-INDUCED OBESITY 834 7100 929 3458 3553 7099 54106 5697 4615 4055 PMC3729906__F1 Molecules examined by immunohistochemistry 4118 3932 3702 5335 2534 55272 6850 4773 896 2623 3726 27086 85451 29851 1043 PMC3731808__F6 Comparison of gene expression changes in human bladder cancer and our mouse model based on KEGG pathway analysis 3845 2261 3265 5605 4609 1030 1029 595 4193 1019 1026 5925 7422 2069 4314 4320 1950 7057 1832 999 9073 PMC3731936__F5 Sequestration-induced loss of protein C receptors links coagulation, inflammation, and endothelial permeability 324 5091 7018 7124 3569 7450 4318 PMC3732459__F2 Innate Immune Responses in Hepatitis C Virus Infection 7706 51311 51284 7098 1283 57506 7187 7189 10010 29110 3661 3665 51135 3654 4615 PMC3733265__F1 Mimicking the BH3 domain to kill cancer cells 572 90427 637 581 PMC3734370__F1 Regulated secretory pathway of a model neuroendocrine cell 627 181 1113 5443 3643 4160 4803 4852 1081 1363 535 1114 107966124 7857 29106 6272 PMC3734592__F5 Ingenuity analysis of representative accumulated proteins in response to inactivation of CRL/SCF system 896 2309 1019 2194 5925 1027 1026 6670 898 6774 6720 7465 993 7069 7296 4780 23764 8714 4097 2729 3162 140809 4193 4089 4088 4149 3084 25 10006 6839 25942 PMC3734825__F7 Upregulation of HSP70 and the phosphorylation of STAT1 induced by bortezomib (BTZ) decrease the cytotoxic activity against ovarian cancer cells 6772 3297 637 572 PMC3735083__F1 HIF-1A regulation in cancer 2475 5371 5300 983 27252 8452 PMC3735707__F6 Maternal factors required for oocyte developmental competence in mice 3948 150763 2820 5209 PMC3736724__F1 Tyrosine kinase (TYK) targeting growth factor and proliferation pathways 2321 2247 7423 5281 8829 3791 3685 1398 1445 5894 4846 PMC3737169__F2 MTX cellular pathway 270 158 8836 2356 132 2618 471 7298 1719 4548 PMC3737553__F6 Our proposed model for two distinct pathways in ICL-induced ATR signaling 5884 84126 11073 545 PMC3739348__F6 Expression of some genes related to the cell cycle and apoptosis were significantly changed after LM23 knockdown, as shown by microarray analysis 1019 4193 1021 1017 355 839 983 324 PMC3741135__F9 Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction 23411 208 2932 355 PMC3741506__F1 ASC-mediated switch between pyroptosis and apoptosis: intracellular pathogens and their products lead to activation of the ASC-dependent inflammasome 114548 9447 841 834 637 836 581 3553 842 PMC3744028__F9 Summary of the proposed role of Pak1 in mediating stretch-induced CTGF upregulation 7046 1956 5879 5058 387 PMC3744446__F1 Past Visits Present: TCF/LEFs Partner with ATFs for Beta-Catenin–Independent Activity 6925 1386 1499 51176 PMC3745214__F1 Targeting TGFB signaling in cancer 4087 4088 4091 4092 7189 6010 4089 7018 PMC3745259__F1 The hexosamine biosynthetic pathway provides the donor substrate for O-GlcNAcylation and other types of protein glycosylation 8473 5238 6675 PMC3745317__F1 Eicosanoid biosynthetic pathway and its activation by RTK/GFR → ERK1/2 signaling 1956 4513 4512 717 4015 8644 5730 PMC3745370__F8 High expression of the ppGalNAc-T13 gene enhances cancer metastasis by formation of trimeric Tn antigen 7273 6382 3678 3688 PMC3746560__F7 TG2-containing adhesive/signaling complexes on the cell surface 4035 4040 4041 207 6714 1499 387 PMC3747497__F1 FGF signalling: diverse roles during early vertebrate embryogenesis 2549 9846 6714 10818 2885 PMC3749718__F7 The putative steps in the redox signaling pathway leading to adaptive activation of transcription factors and upregulation of the expression of cytoprotective proteins following contractile activity in skeletal muscle 57716 3297 7018 PMC3749885__F2 Pim kinase targets and their roles in inflammation and cancer 572 8651 993 2000 995 9021 PMC3750319__F5 Crosstalk of the canonical NFKB pathway with other signaling processes 1540 331 5970 407009 6774 2078 3569 3383 7412 PMC3751673__F3 Ingenuity pathway analysis of the top-ranked network 55540 64109 4783 1233 3598 6367 910 8564 909 6368 8727 131450 PMC3753504__F39 Activation of different death receptor signaling pathways depending on the culture conditions of hepatocytes 8772 581 637 56616 27429 331 PMC3753831__F1 ERK1/2-mediated regulation of the G1-S phase transition 673 894 4609 595 3725 PMC3758473__F2 Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease 406 9575 8864 1408 1407 26224 PMC3759196__F6 RTK/PI3K/Akt signaling 5728 5163 7249 7248 PMC3759196__F7 P53 pathway and retinoblastoma (RB) tumor suppressor protein signaling are shown 472 4193 595 1019 4194 5925 PMC3759360__F2 When Ubiquitin Meets NFKB: A trove for anti-cancer drug development 4050 7187 5971 11201 7189 472 142 PMC3763548__F8 Role of the eIF2A/ATF4 signaling pathway in the transcriptional activation of autophagy genes 83939 468 83734 11337 9474 81631 9140 64422 8678 4077 10533 11345 PMC3766771__F1 Transcriptional regulation of effector and memory CD8+ T cell fates 50615 6774 6775 7249 7248 2475 8178 8320 10365 2308 8842 9021 6932 PMC3766771__F2 Transcriptional regulation of effector and memory CD8+ T cell fates 941 8320 60485 639 PMC3769370__F8 Radioactive 125I Seed Inhibits the Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Triggering DNA Damage and Inactivating VEGF-A/ERK Signaling 7422 545 472 891 PMC3774704__F1 Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets 3958 4280 7099 114548 3586 PMC3775648__F3 Major elements of the noncanonical Wnt/Ca2+signaling pathway 7474 7481 2535 9630 10672 2775 2767 2773 2774 2768 2769 2770 2771 2776 2784 2778 346562 2780 2782 59345 10681 2783 2779 2781 2793 2790 2791 55970 51764 2785 2792 2787 2788 94235 5331 5332 5333 113026 51196 5336 5335 5578 5579 5581 5533 5532 5530 817 5580 818 815 816 5582 5583 5584 5535 5534 5590 5587 23683 4776 10725 4775 4773 PMC3775863__F3 MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention 23114 4215 112 10640 11278 1385 3717 835 596 10413 9839 6654 5567 51655 894 1488 1021 302 3479 136319 627 3927 5921 3915 4684 10487 9788 25932 9575 2099 8301 79602 595 8407 23214 1025 83440 22862 7786 900 5756 22843 604 5290 1356 PMC3776022__F1 GABAA receptor subunit regulation after status epilepticus (SE) 627 3717 6774 1960 PMC3784161__F1 AKT-mammalian target of rapapmycin (mTOR) signalling pathway 3667 5728 6714 7249 7248 6009 2308 2932 PMC3784205__F6 Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans 57104 1375 5164 1376 7019 PMC3785124__F7 Simplified network controlling the fate decisions between osteogenic and adipogenic lineages in huAFMSCs 324 860 2167 PMC3785471__F2 Host Response to Respiratory Bacterial Pathogens as Identified by Integrated Analysis of Human Gene Expression Data 1431 10055 10477 9063 7341 5903 4193 4792 5905 6670 7536 1616 3298 6672 PMC3785791__F1 Abbreviated pathway to illustrate cGMP production and its role in oocyte meiotic arrest 4880 4882 5139 PMC3788099__F7 Association between Inflammatory Infiltrates and Isolated Monosomy 22/del(22q) in Meningiomas 3553 920 3587 3590 972 3482 966 929 3117 3123 23765 3112 965 3108 3122 960 1230 3109 2214 7412 4615 51284 10507 22918 2209 54209 942 7100 2212 969 5788 7305 4481 7097 958 963 4067 1536 5580 596 7454 5578 9846 637 324 3663 3394 3091 PMC3789231__F7 Mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3) 999 8945 2932 6774 55250 1956 PMC3789782__F1 Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling 11073 545 5884 84126 PMC3797434__F7 IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis 9235 4615 51135 7189 29110 3661 3665 PMC3798952__F1 EpCAM and WNT signalling pathways 4072 999 1499 2274 324 1950 6868 PMC3799998__F1 Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila 2475 8408 9706 60673 9776 22863 30849 7405 55626 9140 9474 64422 10533 83734 PMC3805541__F3 MicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214 7494 2104 11009 3815 5469 3624 10580 2475 5581 2099 6401 7157 3215 7422 3383 10725 2180 5458 5606 2353 8743 54541 664 90427 2146 7078 PMC3805993__F2 Novel KP/KISS1R signaling pathways in breast cancer cells lacking the estrogen receptor, ERA 1956 8826 1000 387 4318 PMC3810296__F2 NLRP6 in Infection and Inflammation 7097 7099 9447 4615 10392 64127 171389 5970 3553 PMC3814599__F1 The nuclear pore complex (NPC) and classical nuclear import pathway 23636 79902 4928 57122 55746 23279 9631 23225 8021 9972 10762 7175 5901 5902 PMC3815562__F1 Outline of steps mediating androgen synthesis and metabolism in prostate cancer cells 6770 6715 1646 3283 1586 1645 8644 8630 1588 7367 PMC3817019__F1 How the VEGF-A signaling pathway is linked to its main biological functions.Notes: VEGF-A can bind VEGFR-2 dimer 7422 8829 8828 5335 207 PMC3820944__F6 Representative Tyr phosphorylation sites affected by erlotinib in the EGFR and ErbB2 canonical pathways 1956 2064 2065 6714 7410 2886 5335 5296 6464 5295 2885 8503 3636 2549 5594 5595 5781 399694 5580 5829 2931 983 PMC3821580__F2 Schematic representation of the functional/physical relationship between Dystrophin-Syntrophins-nNOS pathway and miRNAs involved in such signaling, both in a WT and a DMD context 1756 6641 3066 1277 2539 2006 PMC3822800__F5 Diagram represents the molecular cross-talk between TLR2 heterodimers with TLR6/TLR1 and GR through the participation of PI3K 10333 7096 7097 114609 4615 PMC3823115__F1 TGFa/EGFR signal pathway may directly or indirectly lead to c-Met, while HGF/c-Met does not affect the phosphorylation of EGFR 3082 7039 1956 301 2549 PMC3823134__F2 Schematic pathway of different steps of autophagy 10533 2475 596 8408 9140 3916 PMC3823507__F1 Post-translational regulation of iron homeostasis 3077 55240 4089 57817 PMC3823580__F8 Synergistic Effect of Everolimus and Chloroquine on Endothelial Cell Number Reduction Is Paralleled by Increased Apoptosis and Reduced Autophagy Occurrence 1178 2475 596 1977 581 PMC3823960__F6 Summary of retinoid pathway 7276 64220 9227 1592 56603 7052 PMC3824005__F1 Core components of the apoptotic machinery 1630 581 7124 PMC3824073__F2 Outline of the Crosstalk between p53 Family Members and the mTORC1 Pathwayp53 and p63 act upstream of mTORC1 and inhibit mTORC1 activity via multiple transcriptional targets 10769 5728 3486 7249 7248 3479 6009 PMC3826118__F1 Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in carinogenesis 846 1499 7421 4513 6925 999 1591 PMC3827622__F5 Proposed genetic networks of osseointegration 650 860 1499 6662 2056 8864 4862 PMC3828201__F1 ERK and PI3K signaling networks are shown, with illustrations of feedback loops and cross talk 3667 2309 5163 23678 1977 PMC3828559__F1 RAS-RAF pathway and immunohistochemical staining of colorectal cancer specimens with BRAF V600E mutation specific monoclonal antibody 1956 3845 673 PMC3828604__F1 Interactions of stress proteins and cell surface TLR signaling pathways 7099 7494 22926 4615 468 3654 472 7187 7189 29110 8195 3297 3661 PMC3828604__F3 Stress proteins in crosstalk with cytoplasmic PRR signaling 10392 64127 7187 8195 29110 468 3661 3665 PMC3829115__F1 Schematic overview of TF signaling complexes 324 7018 7035 PMC3832239__F2 Mitochondrial Retrograde Signaling at the crossroads of tumor bioenergetics, genetics and epigenetics 10682 6261 207 3480 PMC3832598__F7 CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth 4193 355 2736 PMC3833078__F3 In addition to apoptosis, AR may also regulate other kinds of cell death 367 6010 65057 PMC3833184__F3 Lineage-specific positive selection in the naked mole rat BRCA1/FANC pathway 672 2175 675 2189 2188 5888 2176 2178 2177 PMC3834244__F1 MiRNA biogenesis and function 29102 54487 23405 26523 192670 27161 192669 PMC3836831__F2 Model of PfEMP1 head structure divergence 948 324 5091 PMC3837249__F1 Toll-like receptor signaling in liver cells 7096 7099 7097 10333 114609 4118 4615 51284 7098 51311 3654 54106 7189 3663 3665 3661 PMC3840259__F9 A summary schematic overview highlights the signaling pathway proposed in the present study 367 4512 759 PMC3845396__F1 Regulation of AKT signalling activation 842 572 5728 4193 2475 PMC3847504__F5 Schematic illustration of the correlation in mechanisms among detected parameters 3146 51284 4615 7098 PMC3852103__F2 Most significant GeneGO pathway map 1950 3479 1956 2064 3667 2885 3265 847 5170 5894 8202 5595 5594 8648 595 10499 2100 7031 PMC3852967__F3 Interaction network of genes differentially expressed in response to glatiramer acetate (GA) 1565 6375 246778 1759 4855 1557 3627 3685 3561 5967 5473 3384 4283 947 10870 7412 59067 3606 5788 7186 7075 952 8740 5790 2691 5020 5443 6528 1587 112 181 1669 5066 199 3484 2006 8788 PMC3855473__F1 Canonical NFKB activation by TCR/CD28 and HTLV1 Tax 940 10892 5300 23118 10454 5966 PMC3855668__F1 Model of the signaling pathway mediated by ATM in response to DSBs induced by IR, as proposed by Kitagawa et al 472 10111 4361 672 1869 3014 4193 PMC3856862__F10 Therapeutic Strategies to Increase Human Beta-Cell Growth and Proliferation by Regulating mTOR and GSK-3/Beta-Catenin Pathways 3479 3667 7248 6009 1499 2475 1977 PMC3864542__F1a What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-kinase Pathway 5728 3667 1977 PMC3864900__F3 Ubiquitylation in immune defence and pathogen evasion 7706 64127 81844 373 29110 10010 57534 142678 3661 PMC3865857__F1 Conversion of ω6 and ω3 series PUFA by metabolic enzymes and interaction with de novo fatty acid synthesis 9415 9524 60481 23417 2194 3992 4513 4512 54898 6319 PMC3868844__F6 Proposed signaling network involving mTORC2 and the p38 pathway 64798 2475 2998 29904 6772 7494 147 286410 5348 466 PMC3868999__F1 The Hippo pathway signaling cascade results in the phosphorylation and cytoplasmic retention of effector molecules YAP and TAZ 4485 60485 26524 9113 PMC3871231__F2 New and emerging HDAC inhibitors for cancer treatment 10993 10284 2874 8819 79718 6907 3065 3066 8841 55869 10013 83933 PMC3872270__F2 Many ways to inactivate the p53 pathway in cancer 472 7157 4193 5728 PMC3874981__F3 Beta-catenin dependent and independent Wnt signaling pathways 1499 6010 324 51176 6932 4041 4920 PMC3875397__F1 FOXO transcription factors throughout T cell biology 940 472 5728 7248 7249 6009 10365 1493 50943 604 8320 PMC3875464__F3 PKG regulation of TRPC current and signaling 718 729 5999 5997 7220 PMC3876023__F1 Suppression of regulatory B cells identified in human and animal 613 940 941 920 958 3586 50943 PMC3877903__F9 Fumigaclavine C-induced apoptosis in MCF-7 breast cancer cells through the mitochondrial pathway 572 581 596 891 1017 PMC3878444__F3 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro 3596 6249 572 1438 3659 PMC3878444__F4 Upstream regulators and their target molecules in datasets as identified by Ingenuity Pathway Analysis (IPA) 1236 958 1234 1021 1027 6352 6364 834 8837 10950 6249 330 329 549 2353 214 959 3586 7128 3553 7124 8723 3659 6504 4082 6402 4790 64092 4843 5996 5698 5699 5782 3456 3596 2920 3565 PMC3879613__F7 Biological functions regulated by miR-378 and miR-378* 29926 3939 5478 PMC3880284__F4 Human Mammospheres Secrete Hormone-Regulated Active Extracellular Vesicles 3028 578 290 8842 847 4057 302 4240 57471 213 191 3326 2597 3652 83715 230 10296 474383 PMC3880546__F1 Physiological regulation of the mTOR pathway 92335 5728 7248 7249 6009 1977 PMC3881294__F2 Regulating intestinal function to reduce atherogenic lipoproteins 4018 4099 4245 4248 4247 8694 84649 5091 PMC3881972__F1 Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals: a review of recent research 7100 7097 7099 929 948 7098 10392 64127 114609 4615 7189 7187 64170 3661 4513 PMC3882141__F1 Regulatory Networks and Complex Interactions between the Insulin and Angiotensin II Signalling Systems: Models and Implications for Hypertension and Diabetes 5728 5163 5164 6009 7249 7248 2475 PMC3882755__F8 A Receptor-Specific Function for Notch2 in Mediating Vascular Smooth Muscle Cell Growth Arrest Through p27kip1 6502 4853 1017 PMC3884931__F1 Mammalian target of rapamycin (mTOR) signaling pathway regulation 4803 1950 5163 7249 6009 PMC3887408__F5 Novel approaches of targeting signaling pathways in leukemia 23411 1499 595 2475 22809 6774 PMC3887612__F5 Tau signaling cascade in LPA induced neurite retraction in differentiated Neuro2a cells 4018 387 6010 PMC3887856__F1 Two branches of pathway upstream of mTORC1 3479 6520 8140 6510 3667 64798 5728 7249 7248 23677 8491 6009 PMC3887939__F1 Signaling mechanisms proposed for the mammalian autophagy pathway 55054 100170220 10533 83734 9474 7405 8673 PMC3888942__F6 Axon navigation pathway targeting by miRNAs that differentially associate with Ago2 in an activity-dependent manner 9475 387 2534 25791 2047 2048 3845 1947 5998 7852 6092 9353 6091 64221 1020 2242 5362 3985 5879 27289 6010 3897 23654 8482 PMC3889255__F1 CRH signaling pathway - This map represents the NetPath reactions of CRH signaling pathway 1392 1395 1889 2782 2767 2781 409 2771 2775 5335 4792 5336 4846 408 5970 673 5604 5578 5581 5595 387 142 4790 7020 6925 3725 2353 400629 3164 6770 596 5443 PMC3889649__F5 GLI1 target genes converge on a regulatory pathway that suggests roles in cell proliferation, survival and genomic stability 3172 3169 2534 214 4255 4915 1874 2735 5142 1499 6004 1869 5635 4609 4149 6872 4869 5621 1385 7528 2885 PMC3895871__F1 TWEAK/Fn14 Signaling 7186 7188 7185 7187 5971 PMC3896626__F2 Interaction among differentially modulated genes in the apoptosis biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments 839 355 8772 8717 7124 637 596 4803 572 3562 472 581 PMC3899118__F5 Genome Wide Expression Analysis Suggests Perturbation of Vascular Homeostasis during High Altitude Pulmonary Edema 6369 8326 4775 34 1376 147409 3717 5063 2252 10235 51422 5605 1909 7253 6752 10911 PMC3899800__F2 BRCA1 and its toolbox for the maintenance of genome integrity 3014 9025 165918 PMC3899800__F3 BRCA1 and its toolbox for the maintenance of genome integrity 2177 55215 5888 PMC3899946__F2 Radiation-Induced Bystander Response: Mechanism and Clinical Implications 3014 472 1040 9656 993 1017 995 672 PMC3900493__F1 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms 90952 920 8178 4055 644076 4049 4050 PMC3900881__F3 Sugar for the brain: the role of glucose in physiological and pathological brain function 8682 57103 2597 PMC3901350__F1 Noncoding RNAs in DNA Repair and Genome Integrity 4361 3014 142 10111 9656 165918 9025 672 472 545 993 PMC3901886__F1 Schematic representation of ligand-activated AHR signaling 196 57491 405 PMC3901996__F2 Transmembrane signaling of IL-6, which is a major growth factor for MM 2885 6654 6772 3055 6774 PMC3902172__F7 In vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis 4851 9242 182 4853 54567 3280 28514 PMC3902304__F1 TWEAK/Fn14 signaling cascade 5045 7186 7188 8195 7189 23118 5970 5971 PMC3904431__F3 Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges 1786 9759 6667 1788 3815 1021 27250 998 4170 596 4313 3198 3236 5728 1051 6659 PMC3904668__F1 CD180 is a close relative of TLR4 and together with BCR signaling can promote B-cell activation and differentiation 4064 7409 4615 7099 613 PMC3905285__F4 Possible pathways for lipoic acid attachment to mitochondrial Alpha-ketodehydrogenase apoenzymes 51601 11019 27247 388962 200205 387787 PMC3906322__F2 STAT2 and IRF9 3455 3454 7297 23586 57506 3716 85451 29110 6773 6772 10379 1386 3661 50506 405753 7189 PMC3908275__F5 Interaction of MSCs and HSCs 3280 3815 7852 1000 6608 6469 9242 PMC3909253__F9 Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism 7124 7099 7097 7096 10333 7189 114609 4118 4615 PMC3911500__F7 Schematic model for how S6K1 inhibits TLR2- or TLR4-mediated signaling pathways 7097 7099 7189 10454 23118 PMC3911663__F5 Summary model for rAdV DNA sensing 9447 3661 51428 115004 3665 54106 4615 3663 PMC3913970__F1 BCR/BTK signaling pathway 613 4067 695 6850 2475 PMC3914352__F10 Flow diagram representing the molecular interactions in the Toll-like receptor signaling pathway (from KEGG database) 7097 5879 10333 4615 114609 929 23118 7189 942 5132 51311 51284 54106 7098 PMC3917351__F2 Ca2+ transport remodelling in conferring apoptosis resistance in cancer cells 7220 7223 6786 55503 7442 84876 PMC3918130__F5 Adenovirus elicits IFNAB production by a novel viral induction pathway 7098 51284 54106 4615 3661 3665 PMC3924201__F4 Two mechanisms for growth-factor-mediated regulation of the Hippo pathway: activation of Ras-MAPK signaling and activation of PI3K-PDK1 signaling 4018 1950 5163 4485 60485 84962 PMC3924780__F1 Scaffolding Proteins: Not Such Innocent Bystanders 983 4040 5347 2932 1499 PMC3924851__F2 New Function of Type I IFN: Induction of Autophagy 56832 3454 3455 7084 3716 3667 8660 6772 9140 6773 83734 10533 55054 64422 1977 6194 1975 10379 PMC3925422__F3 Breaking bad: Manipulation of the host response by Porphyromonas gingivalis 718 929 7097 7096 7099 5879 3659 2932 3458 PMC3926505__F1 Key organelles and proteins involved in cellular Cu homeostasis 538 351 10063 627 9973 6647 475 5066 6649 PMC3928074__F1 Phase II Trials of Single Agent Anti-VEGF Therapy for Patients with Chronic Lymphocytic Leukemia (CLL) 6774 405 331 PMC3928130__F1 AMP-activated protein kinase (AMPK) beyond metabolism 100034703 404281 7249 PMC3928130__F2 AMP-activated protein kinase (AMPK) beyond metabolism 4361 10111 472 3014 995 993 1017 PMC3928478__F2 Inositol phosphates and Akt/PKB inhibition, a potential Akt/PKB feedback mechanism.Note: Adapted from Cell, 143(6), Manning BD, Insulin signaling: inositol phosphates get into the Akt, 861–863 3667 5163 9807 PMC3929669__F4 PPARG signaling pathway during high-altitude vs sea-level pregnancy 7124 7186 7189 2885 5894 5468 4513 PMC3931400__F2 Signaling by EGF and PDGF in the regulation of Beta-cell proliferation 1839 7039 1950 685 1956 2064 2065 2066 5163 2146 5728 7248 7249 6009 1977 PMC3932967__F2 Role of Notch signaling in the mammalian heart 650 4313 3084 27302 1003 6909 PMC3940310__F4 Endogenous fatty acid metabolism in the control of hepatic gene transcription 253260 9415 3992 54898 60481 2194 5105 5465 PMC3941218__F1 Insulin- and IGF-1-signaling pathways 3479 3480 3667 5163 23216 9882 7249 572 842 4193 PMC3941591__F5 ‘Ephrin Receptor Signaling’ was the second canonical IPA pathway induced in LR rats upon FST exposure 6464 5921 2885 5894 PMC3943763__F1 Toll-like receptors in antiviral innate immunity 7097 7096 10333 7099 7098 51284 54106 4118 51311 4615 51135 3654 7189 7187 10010 29110 3665 3661 PMC3943797__F1 Coagulation, Protease Activated Receptors and Viral Myocarditis 4322 7018 7098 PMC3943799__F2 Cytosolic DNA sensing pathways 170506 4615 1660 51428 3428 9447 57506 3665 3661 1499 PMC3944211__F1 Bone morphogenetic protein signaling in nephron progenitor cells 331 10454 1386 3725 2353 PMC3945033__F2 Computational simulation of eicosanoid profile in ATP-stimulated BMDM 246 9536 5742 5743 240 5730 6916 4049 3248 4048 1506 PMC3945521__F7 TRIMmunity: The roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity 51428 51295 23118 7187 257397 29110 3394 3439 7098 PMC3946634__F1 Tumor suppressive signatures of miR-200 6657 84441 55534 9839 6935 23512 999 1021 390 595 2626 331 PMC3947657__F4 H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity 104 2331 2258 4060 3751 1634 91975 948 50507 4922 5570 59272 PMC3949429__F2 Two major signaling pathways activated by HBV and HCV in hepatocarcinogenesis 3479 6714 324 3667 2885 1499 572 PMC3951797__F6 Postsqualene cholesterol biosynthetic pathway 4047 1718 10682 6309 1717 PMC3953959__F6 Regulation of TFs activity by degradation modulated by H2O2 7018 472 7157 9817 4193 PMC3954160__F1 Insulin signaling pathway 1398 6517 23624 31 2194 5584 5313 122809 2645 3630 3643 7249 3991 572 2475 2872 2885 3265 369 2997 2932 5499 163688 5834 PMC3955735__F5 Glucose and glutamine metabolism is altered by oncogenic K-Ras 22934 6120 3099 3098 2673 2746 4199 2023 2806 5315 2805 2744 3939 PMC3956536__F5 Heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway 891 983 545 472 3014 5888 PMC3957914__F5 IFN-Beta-mediated regulation of PI3K/Akt/mTOR signaling and pharmacological agents active in this pathway 3454 3455 5163 3716 7297 3667 8660 7249 7248 6009 2475 64223 PMC3959159__F1 Major components of the TGF-ß signaling pathway 4092 4087 4088 4089 85451 PMC395917__F5 BMP4 and LIF signaling in pluripotency 652 3976 10454 4086 4089 6774 331 79923 PMC3959213__F10 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway 875 5209 3276 2147 PMC3962547__F14 Integration of metabolic control, cell growth and proliferation, and their regulation by phosphoinositides 5163 7249 6009 5337 PMC3962777__F2 NEW STRATEGIES FOR TRIPLE NEGATIVE BREAST CANCER – DECIPHERING THE HETEROGENEITY 1956 5728 8821 5782 2475 494551 7465 545 472 367 675 672 PMC3964483__F1 Outside the Box Signaling: Secreted Factors Modulate GnRH Receptor-Mediated Gonadotropin Regulation 2798 6714 2002 3725 7536 2353 1958 7018 1081 3972 2488 PMC3966314__F3 Impact of miR-215 on cell proliferation, cell cycle, chemoresistance and EMT 9839 51514 1719 8317 4172 PMC3966329__F1 Regulation of autophagy by ARV 5728 83939 7942 PMC3970925__F1 Activation of PPRs in cardiomyocytes by DAMPs during myocardial I/R injury 3146 7099 7097 54106 PMC3973006__F8 Schematic model of TGFB signaling pathways for CRP2 induction in VSMCs 4087 4088 387 4089 1386 1466 PMC3973444__F7 Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders 7251 51510 9636 27243 79643 PMC3973656__F1 Curbing autophagy and histone deacetylases to kill cancer cells 8408 64422 10533 PMC3974825__F1 Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer 472 545 5888 PMC3974856__F2 Tolerogenic plasmacytoid DC 7412 7852 5132 54106 1235 920 PMC3977151__F1 GOLGI IN COPPER HOMEOSTASIS: A VIEW FROM THE MEMBRANE TRAFFICKING FIELD 540 538 475 9973 10063 PMC3977945__F1 Simplified Wnt/Beta-catenin pathway 4040 4041 324 1499 PMC3977945__F3 Ubiquitination-mediated regulation of the core Wnt/Beta-catenin pathway components 4040 4041 84133 54894 324 1499 9097 1540 25831 378925 64750 9958 57154 79960 PMC3978476__F4 Major metabolites and genes contributing to the choline metabolism pathway 81544 10908 375775 1119 23646 8398 6582 30814 1120 5321 113026 8399 PMC3978582__F5 Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and experimental discs 4133 165 4060 5970 4790 3240 613 149233 1536 10392 10010 2268 PMC3978875__F6 Proposed signalling interactions between C-type natriuretic peptide (CNP) and mechanical loading in chondrocytes 3553 1267 4882 4883 1445 1893 PMC3979117__F1 Schematic illustration summarizing apoptotic signaling through the death receptor pathway and the mitochondrial pathway 355 572 637 4193 4194 23411 PMC3979852__F8 Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages 6346 1237 7099 PMC3983488__F1 Matricellular TSP1 via CD47 restricts NO-sGC-cGMP signaling 961 140885 948 875 6714 PMC3984774__F4 RB/E2F pathway 4609 1019 898 4149 6502 PMC3984876__F1 Cilia in the nervous system: linking cilia function and neurodevelopmental disorders 6608 6469 4040 4041 PMC3985519__F3 Down-regulation of the clotting cascade by the protein C pathway 324 100187907 387 5879 PMC3985661__F8 Schematic representation of PARP1–TDP1 coupling for the repair of Top1–DNA covalent complexes 142 55775 7150 4361 PMC3989668__F2 Ubiquitin-proteasome system maintains the balance between quiescence, self-renewal, and differentiation of HSCs.(A) The E3 ligases Itch, SCFFbxw7,CBL and SCFSkp2 maintain the quiescence of the HSC by targeting Notch, c-Myc, and STAT5, among others 83737 55294 867 6502 7428 2177 7398 4193 PMC3990910__F1 Mammal Notch receptors, ligands, and canonical activation pathway 4851 4853 4854 4855 1950 441478 102 PMC3991209__F1 Diagram showing activation of Notch signalling 4855 4853 4851 4854 5045 3280 23493 23462 PMC3991635__F4 Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells 2033 699 7040 9700 545 4193 5591 9184 2932 472 219972 4088 10744 4089 6502 7157 5925 9232 701 1111 10297 8379 324 11200 4085 1030 1027 1647 7532 991 10459 1028 5111 995 993 595 896 894 994 9134 8900 891 890 898 9133 902 1019 1017 85417 1021 5347 990 999 25 7465 9088 5933 8556 8555 8317 7027 11138 6418 140739 PMC3993568__F10 PI3K/Akt1 pathway is a downstream effector of Jak2/Stat5 signaling in luminal mammary epithelial cells 5617 5618 6714 3717 5163 207 5728 PMC3995050__F1 The PI3K/Akt/mTOR pathway 5728 5163 5164 7249 7248 4193 2475 6009 572 253260 PMC3995058__F4 Mechanism of rejection of MHCIINEG myeloma cells by Id-specific CD4+ T cells 920 914 939 960 969 324 4345 4283 3627 958 941 942 29126 940 1236 PMC3996470__F1 Receptor-mediated endocytic pathway in nonpolarized mammalian cells 10577 4864 3949 PMC3996849__F3 Intestinal cholesterol absorption is a multistep process regulated by multiple genes 39 29881 3156 4547 64241 64240 95 7038 PMC3998185__F7 Metastatic Stem Cells: Sources, Niches, and Vital Pathways 5352 4015 3371 6387 7412 7852 6714 8549 847 23493 6774 4086 1956 1950 3589 1435 6279 4283 2919 1436 3579 8205 PMC3998839__F1 mTORC1 is a component of mTOR that is directly inhibited by rapamycin and rapamycin derivatives like everolimus 3479 1950 5163 5728 7249 7248 6009 596 572 595 29904 1975 27250 1977 PMC3999940__F3 Case study of the RegPhos-discovered phosphorylation networks involved in BCR signaling pathway 867 933 914 4067 6850 613 29760 695 2885 8915 1040 930 PMC4002322__F1 AMPK-p53-mTOR pathway in metabolic adaptation 6009 55332 2593 PMC4002322__F2 p53 regulation of energy metabolism 3099 57103 27165 9997 PMC4002662__F1 Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling 1956 4050 7186 7189 7188 7185 5728 7187 2475 5970 5971 PMC4002811__F2 Peli1 mediates IKK activation by the TRIF-dependent TLR pathway 7098 7099 4615 57162 51135 57161 3656 3654 246330 7187 7189 3661 PMC4002915__F2 Signal pathways of IL-17 84818 23765 3605 3716 7189 7187 2932 PMC4003231__F1 Immune pathogenesis of gastric mucosa damage in H 6364 8772 637 PMC4003375__F1 Nck proteins as the newly identified adaptors between the BCR complex and BCAP/PI3K/Akt pathway 930 4067 6850 695 2885 5163 2308 572 PMC4003867__F1 Emerging role of Interleukin-22 in autoimmune diseases 3716 7297 6772 6774 PMC4007207__F9 Model of the role of an epidermal barrier defect in tumour protection 3265 85480 8480 PMC4007997__F4 Molecular pathway analysis of regulated membrane protein changes in RLSCs as they undergo hepatocytic differentiation 3957 312 50814 3960 1015 3728 7430 2023 54751 26136 7431 3921 PMC4007997__F5 Upstream regulator analysis of membrane protein changes in differently regulated proteins involved in cell-to-cell signaling and interaction 3728 7431 10449 3691 87 3675 23603 999 6591 7171 9563 5742 3183 5162 3958 4128 PMC4008004__F1 Hyperglycemia alters the expression of multiple genes of the transforming growth factor‐B (TGF‐B) pathway through the polyol pathway in retinal vessels 7046 657 4851 3224 3460 960 7076 4512 10628 6646 8202 2004 4601 PMC4008642__F1 Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation 1950 1956 5728 673 2475 5163 4286 9049 PMC4009948__F1 Cap-dependent and elongation translational control by GNRH 2475 29904 1938 1977 1958 2488 3972 2002 6722 PMC4010328__F5 TOB1 was involved in regulation of tumor growth and metastasis via the PI3K/PTEN signaling pathway 1950 10140 5728 999 595 1499 PMC4016907__F5 Both images were created using IPA 10000 2931 6198 310 3958 2932 367 3551 9212 1147 7157 11200 5591 5578 4751 9261 5579 814 5576 5728 5166 6446 6009 4193 PMC4017039__F1 Intracellular signal propagation of human toll-like receptors and corresponding ligands in innate immunity 929 7098 7096 10333 7097 54106 7099 51284 7100 4615 54472 114609 7189 3654 51135 PMC4019000__F1 Dietary Fatty Acids and the Aging Brain 627 28 3643 5728 5163 5164 3416 4015 26136 2932 2931 6256 PMC4019937__F2 Phylogenomic reconstruction of archaeal fatty acid metabolism 65057 1380 95 PMC4022607__F1 Angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development 60485 4485 9113 8463 7003 7005 7004 26524 8161 154810 51421 PMC4024059__F1 STAT3 and epithelial–mesenchymal transitions in carcinomas 1956 3977 9180 5008 1950 6774 9021 PMC4026543__F2 EPH receptors crosstalk with EMT-related signaling pathways 2049 1969 5879 1499 2002 999 2050 PMC4030844__F2 AR-independent promotion of prostate cancer (PCa) cell proliferation and angiogenesis by the SUMO pathway 595 29843 26168 6670 7341 PMC4030989__F1 Sphingolipid pathway and basic structural units of sphingolipid biosynthesis 8877 56848 253782 29956 204219 10715 79603 91012 64781 8560 123099 130367 81537 PMC4031445__F2 Signal transduction by prostaglandin receptor EP2 6714 2932 5216 1499 1956 PMC4031539__F5 Summary figure of the switch from Pu.1 interaction with coactivators to corepressors caused by Runx1 deficiency 6304 1788 648 25942 9055 6839 55929 8520 23314 284695 23411 1786 8607 55257 3276 5928 5931 10856 10419 11331 23468 3930 8841 80314 10951 10498 10284 8819 2874 7464 861 57727 3065 3066 23118 5978 6594 6599 6595 86 9188 10155 6601 1108 1107 8932 6598 6604 9112 142 6597 7089 7088 55193 11177 6605 7090 23028 53615 6603 7091 387569 PMC4032983__F6 CK1 in Wnt-signaling 4040 4041 1499 387 324 6010 26037 PMC4032983__F8 CK1 in Hippo signaling in vertebrates 999 4771 4485 9113 26524 1499 PMC4034039__F5 Proposed lignin degradation pathway in C 3010 717 7054 PMC4037312__F3 PI3K/AKT/PTEN signaling, which modulate NOXs-derived ROS 5728 7249 7248 2475 1499 PMC4037811__F1 An Inside View: VEGF Receptor Trafficking and Signaling 1003 8829 961 6714 PMC4037835__F1 The MDC–MMSET–UBC9–53BP1–BRCA1 pathway 9656 8554 51588 672 PMC4038461__F6 Finding Novel Molecular Connections between Developmental Processes and Disease 6714 3091 2475 4846 PMC4040351__F2 From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling 54567 28514 10683 3714 182 4855 4851 4854 4853 55294 2932 3280 23462 4609 595 596 1236 PMC4046121__F5a Differential Transcription of Fathead Minnow Immune-related Genes Following Infection with Frog virus 3, an Emerging Pathogen of Ectothermic Vertebrates 6497 4091 2885 7189 4092 64750 10454 7030 7421 3224 860 8928 3065 3196 145258 4838 5308 PMC4047762__F6 ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway 54567 4089 4090 4086 3397 23462 23493 3516 182 PMC4048572__F8 Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy 3479 5728 2309 9140 9474 23411 3065 3066 8408 PMC4050971__F4 Ingenuity Pathway Analyses: Details are as in 1356 6010 6242 203259 79608 5727 55293 55854 7138 56927 79142 26022 6191 57863 9191 199731 57561 PMC4051169__F8 Mitotic roles of Polo-like kinase pathway 5426 9748 7465 4661 991 324 51343 9232 PMC4053166__F1 Meet the terminator: the phosphatase PP2A puts brakes on IRF-3 activation 29110 3661 581 10399 10013 PMC4053348__F1 Role of MALT1 in signaling to NFKB in ABC DLBCL 613 4615 973 974 5697 6850 51135 3654 695 84433 8915 10892 1540 PMC4058004__F1 Simplified biotransformation scheme of tamoxifen in man. Tamoxifen is mainly N-demethylated to NDM-TAM and subsequently 4-hydroxylated to endoxifen 1576 54657 8205 1565 1559 PMC4060531__F3 Genetic Basis of Diffuse Large B Cell Lymphoma 613 958 973 974 84433 8915 10892 4615 3662 604 PMC4062707__F2 Signalling pathways activated by chemokine receptors 998 5879 387 6714 5058 6093 207 2475 3725 PMC4062840__F2 Regulation of Akt phosphorylation 5163 5728 23035 23239 PMC4063414__F3 Phosphoglycerate mutase 1 (PGAM1) controls the levels of allosteric regulators 3-phosphoglycerate and 2-phosphoglycerate 2539 25796 5226 22934 5723 29968 5223 PMC4064060__F4 Molecular interactions between Wnt/Beta-catenin and PPARG signaling in colorectal cancer cells 2932 324 1499 999 5728 595 PMC4065097__F1 Simulation of Swanson's Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico 4695 8814 23604 1032 5967 5594 9402 929 1576 2697 2353 5743 6774 3315 9338 10598 51561 PMC4074489__F4 p58IPK and UPR-associated inflammatory signaling pathways 22926 7186 83939 468 PMC4075065__F1 Insulin/mTOR signaling pathway and also the extrinsic modifiers that are present in diabetes 8471 3667 8660 2475 10000 207 208 PMC4076091__F7 GW1516 intervention inhibits progression of hepatic steatosis in mice 1374 22937 3638 2194 5105 PMC4081080__F3 miR-143/145 modulate signaling through the Ras-MAPK pathway 1956 5921 2002 6239 PMC4084431__F1 Genes directly related to dopamine functioning 1312 4129 4128 1812 1816 1644 1813 7054 1814 1815 PMC4084917__F7 Fatostatin Displays High Anti-Tumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling 2194 3156 3157 3949 4597 4598 367 PMC4085993__F4 Iron Homeostasis in Peripheral Nervous System, Still a Black Box? 3084 4359 4155 PMC4087218__F4 Resveratrol on protein phosphorylation in the insulin signaling pathway and the mTOR pathway of obese mice 3667 5163 5728 2475 1977 PMC4091179__F10 Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells 2280 2475 7072 7042 9776 PMC4091760__F2 Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1A signaling node 196 405 6908 PMC4094593__F9 Diagram of the roles of miR-206 in hepatocellular carcinoma (HCC) HepG2 cells 581 4854 3280 PMC4100437__F1 Hypothetical model of chemoresistance in human ovarian cancer cells 1021 1019 4193 581 331 355 PMC4102553__F5 Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment 4513 4512 4015 PMC4102832__F2 Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities 4040 2932 3014 1499 PMC4106164__F1 PD-L1 expression and tumor-infiltrating lymphocytes 50943 920 6367 3460 3459 1233 5728 PMC4107035__F2 PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA 2885 10617 4763 5163 92335 7248 6009 2475 1977 PMC4107064__F1 Progress in Central Nervous System Lymphomas 3565 6387 10563 3586 7099 613 4615 695 596 3716 3717 3654 51135 6774 6778 5292 4609 PMC4107230__F6 Different mechanisms of signaling for EMT which might be induced by FGF10 2255 2932 2475 324 1000 1017 7076 PMC4107774__F1 The Hippo signalling core cassette in mammals 4485 9113 26524 PMC4110182__F1 SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease 50628 79833 54960 79760 25929 8487 23658 11157 51691 51690 27258 25804 57819 27257 10236 PMC4114568__F4 PleiotRHOpic 58480 7204 5058 5754 387 5879 60626 7852 65979 998 1910 5979 2668 PMC4117527__F5 Genome-Wide Analysis in Human Colorectal Cancer Cells Reveals Ischemia-Mediated Expression of Motility Genes via DNA Hypomethylation 1116 25907 3914 3308 55818 9518 133 341 7124 3949 3479 8570 8450 5329 214 2099 5284 54554 3565 6195 5094 2358 10252 5214 80314 9314 7323 55294 1457 324 5728 4087 80318 5930 4088 23327 10579 164 4893 1407 PMC4117608__F6 Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health 2597 2932 650 3725 408 2752 790 3248 533 10300 10960 55082 51586 4726 290 87 5243 55872 8875 7386 8993 7046 55718 7846 5437 6733 55234 9861 5702 6749 5447 6636 5710 113402 5770 6207 PMC4120759__F1 ER stress and UPR 22926 83939 440 468 PMC4121105__F1 KEAP1/CUL3/RBX1 E3-ligase protein complex 9817 9978 8452 PMC4122637__F3 PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics 116085 56606 6568 10786 9429 9356 9376 55867 9390 3965 5174 10257 PMC4123127__F1 Hippo in the Path to Heart Repair 4485 60485 9113 26524 PMC4123209__F2 Tale of two cytokines: IL-17 and IL-22 in asthma and infection 7188 7186 7189 7297 3716 10682 6774 84818 PMC4124246__F1 Signaling pathway induced by malarial ligand during liver-stage infection 57506 3661 3665 2821 4615 545 29110 3458 7097 10333 PMC4124648__F2 Possible therapeutic interventions on molecular mechanism inducing necrotizing enterocolitis 1950 3146 7099 PMC4125208__F4 Ingenuity pathway analysis (IPA) revealed TGF-beta signaling as the top “connected” network of differentially methylated candidates in HDM-exposed group 8604 6497 651 4088 81622 9607 4087 7226 23228 9514 7042 4481 10846 27177 8974 58487 5593 PMC4127596__F1 Autophagic process and some of its major regulators 5163 3667 7249 7248 6009 8408 9140 9474 PMC4127596__F2 Beclin 1, its protein interactions and its role in autophagy 23118 10454 55626 65018 7405 81671 3146 7189 8975 PMC4127946__F9 Proposed model for the role of CD28, CTLA-4, CD80, and the PD-1/PD-L pathway in mice after ischemic stroke 4280 324 941 PMC4128878__F1 Alpha-catenin 999 1499 324 PMC4133502__F1 Step forward back to (induced) fetal 472 2002 3725 PMC4133905__F2 Normal, physiological insulin signaling transduction (left) and an altered pathway following insulin withdrawal (right) in adult hippocampal neural stem cells 7248 7249 2475 PMC4133953__F8 Cell cycle regulation by miRNA and their targets dysregulated in cervical cancer 995 993 1017 983 1021 1019 595 442917 2308 PMC4134018__F1 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii 7792 8411 1509 81876 6010 PMC4136196__F5 Coinfection of Filifactor alocis with P 10131 5479 5763 3190 26986 79026 PMC4136419__F1 Targeting the B cell receptor signaling pathway in B lymphoid malignancies 4067 695 6850 5336 84433 8915 10892 4609 930 PMC4138699__F7 GAi-mediated activation of the PI3K-Akt-mTORC1 pathway in response to EGF 1950 5163 2549 2932 PMC4139969__F3 Role and targeting of Aurora kinases in head and neck cancer 23332 9183 10607 57122 2305 1062 11243 55139 23424 8452 4792 79866 90293 53615 55958 5921 23397 22974 5528 6790 9212 9918 4691 7157 54888 84962 10592 672 5499 51199 10051 207 4638 5058 PMC4142057__F2 NFKB and p53 antagonises each others activity 4193 100420631 545 PMC4142280__F4 Signaling crosstalk between the TGF-Beta-activated pathway and other pathways during EMT (according to Xu et al 4087 4088 4089 1499 999 1003 23462 PMC4147692__F1 Involvement of HIV proteins in intrinsic apoptotic pathways: The viral proteins are marked in yellow 355 5894 572 317 637 5728 472 581 545 PMC4147692__F3 Apoptosis induction by the HIV-1 envelope protein at the cell surface 7852 983 920 2475 581 PMC4148086__F1 Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands 57650 8161 1869 5518 207 4193 1499 1977 2308 PMC4148087__F3 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention 5728 100133941 960 23152 3480 PMC4149926__F1 Cytomegalovirus microRNAs 9134 947 79184 23741 10982 8773 9341 4277 998 527 8766 5878 PMC4151153__F2 Toll-like receptor 4 (TLR4) signaling pathway by Lactobacillus casei OLL2768, Bifidobacterium adolescentis MCC-75, and Bifidobacterium adolescentis ATCC15705 in bovine intestinal epithelial epitheliocytes (BIE cells) 7099 929 59307 3656 54472 3725 2353 3565 PMC4151374__F2 Interaction network using Pathway studio 3909 3818 7124 5340 51542 348 23627 5621 503542 PMC4152843__F5 Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries 6402 6401 80833 10125 7184 1606 6678 633 3543 3872 929 972 2517 3600 4283 7412 3598 660 3109 4261 5743 3587 3134 2921 25865 29108 26298 4018 5999 7318 PMC4155268__F5 The cytoprotective signaling of EPCR-APC 324 857 387 5879 PMC4155324__F4 Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma 2099 595 6667 1869 PMC4156155__F1 INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE 7099 6714 4015 PMC4156761__F8 Schematic model shows the downstream signaling pathway of PIP5K1A and the effect of ISA-2011B inhibition 8394 5728 367 983 6502 PMC4157363__F1 Determinants of Breast Cancer Progression 3977 8975 999 3976 3236 5728 717 718 PMC4160334__F1 Receptors and signaling pathways involved in proliferation and differentiation of Sertoli cells 1839 2100 6714 2099 595 1761 596 581 1027 PMC4163377__F1 MicroRNA and their involvement in oncologenic signaling cascades in pancreatic cancer 1956 1499 4089 3845 673 1021 1019 595 4609 596 675 5888 4193 2475 PMC4163898__F1 Stress-induced premature senescence (SIPS) signaling pathway 1021 1019 472 545 4193 PMC4166715__F4 mTOR transcriptional activity 3480 3667 8503 5728 5582 5170 2475 253260 3091 1975 7248 6009 6194 7249 5563 10670 10325 58528 64121 673 6418 5291 PMC4166762__F1 Glucagon-like peptide 2 receptor (Glp2r)-induced intracellular signaling in hypothalamic proopiomelanocortin (POMC) neurons 9340 3953 5443 3643 PMC4167640__F1 Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment 4485 60485 55233 92597 26524 9113 PMC4169465__F1 The Role of Iron in Prion Disease and Other Neurodegenerative Diseases 7018 1356 55240 PMC4169706__F2 Genome-wide association analysis of anti-TNF drug response in rheumatoid arthritis patients 3908 8601 84894 6095 653 7456 1136 3741 5592 22926 10165 729 1305 1600 PMC4171549__F2 Computational gene interaction predictions: network of E12 telencephalon-specific miRNA involved in the Neurotransmitters and other nervous system signalling pathways 801 627 10487 8829 6863 4205 3190 1956 9759 2643 3717 998 6667 3759 3551 10094 7402 23621 3977 3337 7280 2861 115 3915 PMC4172484__F7 Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling 182 100188776 3280 PMC4174315__F7 Mechanistic model depicting the factor association of DDB2 and XPC with ATR and ATM, influencing the DDR pathway in response to UV damage 472 545 7507 PMC4176051__F2 Pathway analysis 91860 92359 4607 27173 8804 6442 2673 26509 1297 7157 79733 57447 PMC4178212__F2 Activation of p53 is predicted to increase the flux through gluconeogenesis 5106 5091 5105 2805 PMC4183535__F4 Maternal Obesity and Tobacco Use Modify the Impact of Genetic Variants on the Occurrence of Conotruncal Heart Defects 23743 1788 29947 635 6948 10588 23382 875 2729 5981 4255 2940 2938 2939 2941 2946 27306 4846 PMC4183996__F4 Involvement of microRNAs (miRNAs) in epithelial-mesenchymal transition (EMT)-related metastasis 3082 1950 387 4087 4088 5728 2932 1499 999 1000 9839 6935 PMC4184083__F1 Addition of RASAL1 to the canonical scheme of the RAS-coupled MAPK and PI3K pathways 8437 5728 673 5163 2475 PMC4184842__F6 Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFKB Inhibitor 3566 7535 3718 3716 8651 3667 2885 3265 4792 6778 PMC4186703__F9 Non-Classical Renin-Angiotensin System and Renal Function 59272 1636 367 PMC4194224__F7 Expression of Suppressor of Cytokine Signaling-3 (SOCS3) and its role in neuronal death after complete spinal cord injury 581 9021 6774 PMC4196646__F1 Signalling pathways connected to autophagy 27185 2932 1499 2475 PMC4197205__F1 An IL-1-induced signaling pathway is mediated by K63-linked polyubiquitination of IRF1 8877 7189 6352 PMC4197207__F3 PRR signaling in testicular cells 7097 10333 7100 7099 7098 4615 PMC419721__F7 Schematic model of signaling events to MEKs and Erks induced by threshold concentrations of Epo 2056 2057 2931 2932 PMC4197875__F3 Hippo signaling pathway in stem cell biology and cancer 4485 4771 9113 26524 PMC4198363__F5 A role of autophagy in PTP4A3-driven cancer progression 2475 8878 8678 5289 11156 9474 PMC4200329__F4 Schematic representation of the amniotic fluid eicosanoid profile 5228 5226 4050 PMC4205566__F1 A Signaling Network Induced by B2 Integrin Controls the Polarization of Lytic Granulesin Cytotoxic Cells 3383 472 5594 5795 6654 2316 840 2268 10451 3937 9402 4690 868 8874 5921 1213 79834 64098 5829 3611 7531 4739 3987 10044 2185 9404 10483 6595 27128 57091 116985 1124 2214 7402 3820 6434 8239 7006 100124696 4643 8808 51752 PMC4211615__F1 EMT-associated signaling molecules in glioma cell 3082 1950 3371 1956 7852 960 6774 6935 PMC4211625__F1 Tyrosine phosphatase SHP2 is required for the proper timing of neurogenesis and gliogenesis and the balance between them during CNS development 3976 1270 2549 2885 6772 6774 4609 PMC4214431__F1 Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut 6935 9839 7291 PMC4216607__F1 Management of Pediatric and Adult Patients with Medulloblastoma 6469 6608 2736 324 4609 1019 4149 PMC4219921__F1 Steroid hormone synthesis pathways in the adrenal gland and testis 6770 1583 412 1586 4519 3284 1584 1585 PMC4222074__F4 Network links between 23 genes in pathway of mismatch repair and three driver genes 4008 26018 3983 10714 121227 10397 9616 4292 1499 6119 10128 4437 6742 5395 9156 6117 27030 5378 PMC4222351__F4 P-21 activated kinase (PAK)1 in canonical and non-canonical NFKB signalling 5879 998 5058 5970 5971 7099 PMC4223653__F3 Neurology of mTOR 4763 5728 7249 7248 8408 9706 2475 PMC4226052__F6 Up-regulation of the type I IFN canonical pathway by IFNB treatment 7297 3716 6773 6772 10379 3434 5696 3437 PMC4230700__F3 Disseminated cancer cell dormancy: an awakening field 7040 7042 1956 652 655 7046 7049 7048 558 659 4086 4088 4087 1019 10397 896 PMC4231066__F6 Ethanol Negatively Regulates Hepatic Differentiation of hESC by Inhibition of the MAPK/ERK Signaling Pathway In Vitro 2249 3082 595 PMC4231374__F1 Hypothetical representation of PI3K/AKT/PTEN signaling in pancreatic Beta-cells is shown, which modulate NOXs-derived reactive oxygen species (ROS) generation 5728 7249 7248 2475 2932 3091 1499 PMC4232400__F5 E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice 55224 1119 5833 5130 56994 10162 23761 10400 9791 81490 PMC4245043__F1 Model of the Fanconi functional pathway and protein components 675 2191 545 22909 PMC4248710__F13 KLF4-dependent miRs cooperatively promote RAS-ERK pathway activity by cotargeting of pathway inhibitors 10252 2885 161742 4763 5921 PMC4249256__F5 Illustration of the proposed crosstalk between insulin/IGF1 and IL-17 signaling pathways 3479 84818 2919 6364 7189 PMC4249809__F1 Role of TGF-beta in healthy and OA cartilage 7048 4090 4086 4087 4088 4322 6662 PMC4250230__F4 Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond 3082 3480 5159 4893 PMC4251421__F2 Simplified diagram of the mammalian target of rapamycin (mTOR) signaling pathway and its relationship with autophagy and apoptosis 7248 7249 6009 6010 PMC4252580__F2 Aldosterone on insulin sensitivity and secretion 81 3667 3480 51552 5163 6714 5879 6446 PMC4253844__F2 Cholesterol in brain disease: sometimes determinant and frequently implicated 19 4035 348 PMC4254928__F3 Insights into Molecular Features of Venerupis decussata Oocytes: A Microarray-Based Study 54361 8325 1857 1499 4040 324 PMC4258093__F1 PI3K signaling 2475 3667 253260 5163 5728 7248 23678 7249 6009 PMC4258159__F5 The PI3K/mTOR signaling pathway upon stimulation with growth factors, with an emphasis on the phosphoregulation of PRAS40 3667 5163 7249 7248 6009 2475 64798 1977 1975 PMC4259288__F4 A.Genes with altered expression upon miR-224 stimulation are involved in the cell cycle control 472 545 4149 4089 4088 2932 1017 3084 25942 PMC4259948__F1 Schematic summary of the molecular mechanisms of HLJ1 in suppressing lung cancer tumourigenesis 7528 3727 6772 901 4869 1992 7020 83667 10628 8091 586 960 1026 4313 999 800 PMC4260983__F1 Sex hormone biosynthesis and degradation pathway 3283 6716 1543 1545 6715 54658 1312 367 PMC4262066__F3 Schematic presentation of mechanisms leading to cell cycle deregulation in growth plate dtd chondrocytes 4088 1499 1021 1019 993 PMC4263397__F9 Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra 9628 216 5309 2255 627 7054 4841 PMC4263456__F8 Myosin II accumulation and contractility are governed by a mechanosensitive control system 6022 10788 8826 PMC4265312__F2 TLX: A Master Regulator for Neural Stem Cell Maintenance and Neurogenesis 3603 6657 53335 429 7476 652 5460 5728 5076 PMC4265676__F7 Schematic model of WRAP53B function in the DDR pathway 9025 3014 7275 9656 472 165918 672 5888 PMC4272446__F2 NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease 64127 8767 331 83737 329 330 7128 23118 257397 8517 90268 5599 1432 4792 5970 3725 3576 1672 PMC4275311__F1 Cellular and metabolic functions for autophagy in cancer cells 673 83939 468 4609 8408 9474 PMC4276934__F2 Reactome mapping of differentially-expressed genes 3717 3458 3716 3459 11099 5371 6672 5724 4502 3662 3394 10379 3663 3665 3660 3659 3664 3661 10437 PMC4277124__F12 Proposed underlying mechanism for the effect of SCE on drug metabolizing enzymes and drug transporters via Nrf2-mediated signaling pathway 9817 8452 2941 1728 2730 4094 PMC4278306__F2 SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types 64321 6659 1499 6469 2735 6657 2736 2737 3280 6656 8463 PMC4281841__F2 Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases 9575 355 5465 84649 1066 PMC4283622__F1 Capecitabine activation and subsequent 5-FU activation, action, transport and catabolism 8824 978 7378 1890 151531 4524 7083 7298 7372 5471 1806 7371 1807 6240 6241 PMC4284388__F3 Platelet signaling induced by GPIb-IX-V and required for AIIbB3 activation 7450 6850 6714 4067 5266 5879 5336 PMC4285539__F9 Signaling model for IP-10 production induced by MRP8/MRP14 7099 4615 29110 3661 PMC4292165__F1 Signaling pathway of cell surface TLRs 948 929 7096 7097 10333 7099 4615 114609 51135 3656 10010 406943 51014 23118 7187 257397 29110 79671 406938 3552 3553 PMC4292994__F3 Host genes with reproducible microbiome associations across cohorts 5771 7334 8517 6774 1432 10454 64127 8767 7294 3592 1611 51561 3593 133396 PMC4302648__F4 Schematic plot of lncRNAs expressed in NSCLCs and their functions 101805488 100124700 6934 85409 4609 100885775 55384 999 1000 2621 PMC4307112__F6 Differentially expressed genes in digestion and metabolism pathway between grass carp before and after food habit transition from transcriptome analysis 355 2308 3630 367 1506 5327 8544 1080 PMC4307326__F4 Protein–protein interaction pathways are illustrated 5290 2475 8289 207 7157 22985 7316 983 57448 9133 11190 PMC4307326__F5 Some possible signaling pathways activated by SF-CSNPs which may regulate metabolism of proliferating cells through Ubiquitin C (UBC) 1956 958 7187 8737 23118 4193 207 2475 1977 PMC4309684__F8 Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization 4738 6500 3845 55294 PMC4312878__F1 Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond 3394 7099 467 PMC4313578__F3 Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease 3479 7249 7248 6009 2308 2309 2152 64798 64223 PMC4315039__F2 Functional components of the GDR pathway 545 472 1869 PMC4315049__F2 Secretion of FABP4 in association with lipolysis 364 3667 2638 5140 2167 4099 PMC4315929__F7 Cilia assembly and disassembly cycle 146057 10013 79598 80184 5347 1856 PMC4317307__F7 Proposed models of adiponectin metabolic pathway and associated genes 9370 79602 51094 26060 4513 3565 3606 PMC4320441__F3 49 genes whose functional domains were changed by DAS exons 57634 1839 116985 1950 7039 23365 1956 4254 6464 3815 2885 1029 207 7248 4193 7249 7157 2475 6009 PMC4320984__F8 Activation of Beta-catenin Signaling by TFF1 Loss Promotes Cell Proliferation and Gastric Tumorigenesis 7031 2932 1499 595 PMC4320988__F1 Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis 3569 3570 960 3716 3717 4921 4088 6774 7291 4089 4015 9839 6935 PMC4322534__F3 Signalling networks in mouse and human iPS cells 3976 2885 6774 2475 9314 79923 6657 3977 PMC4323104__F7 Clinical Proteomics Identifies Urinary CD14 as a Potential Biomarker for Diagnosis of Stable Coronary Artery Disease 5265 152007 114990 152189 427 563 2720 3964 2147 999 350 1785 929 6548 3038 5294 2517 5586 1434 966 PMC4327859__F1 TLR4/NFKB signalling pathway and TLR4/ MAPK signalling pathway in gastrointestinal epithelium 7099 4615 51135 3654 7189 23118 10454 8195 PMC4332439__F7 Interplay model of Wnt/Beta-catenin, LPS/TLR4, and growth factors in ENS 3929 7099 114609 4615 51135 3654 7189 2932 324 PMC4332478__F3 Integrative Multi-omics Module Network Inference with Lemon-Tree 2261 3643 1956 5156 889 5728 1019 1030 1029 5925 4613 4193 7157 898 4194 100144748 PMC4333106__F2 Canonical and alternative androgen biosynthesis pathways 1586 1583 6715 6822 412 PMC4333386__F8 The functional interaction between RecQ helicases and the FA pathway 4361 5888 9400 641 PMC4335252__F10 Molecular mechanism of attenuation of the PI3K/Akt signaling pathway by gingipains 5163 572 2475 PMC4338943__F1 Retinoid signaling (RA) signaling pathway 5950 1592 9227 83875 56603 340665 216 8854 220 1381 1382 64577 127 157506 10170 10901 PMC4339951__F1 TGFB pathway in muscular dystrophy 6696 7048 8425 PMC4340667__F4 Targeting mitochondria metabolism for cancer therapy 4522 6647 10797 6648 PMC4342515__F1 ncRNAs affect Akt pathway in cell cycle 8829 2064 57799 723778 4193 51147 472 1869 5948 693223 6668 1017 6667 1019 1021 894 PMC4342515__F2 ncRNAs affect CDKIs and Myc pathway in cell cycle 894 1017 1788 1789 554213 1021 1019 595 1977 10401 10642 4084 2475 PMC4342984__F6 The figure shows a scheme illustrating the ASARM-model and the pharmacological effects of SPR4-peptide (bimodal) in HYP and wild type mice 1758 8074 5251 PMC4344557__F2 Proposed mechanism of action of yerba maté on the modulation of the PI3K-AKT signaling pathway 1499 5163 3667 8660 208 PMC4344844__F3 Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development 4040 4041 999 1499 324 PMC4346874__F1 Apoptosis pathways in cancer 355 8717 7186 7188 8772 85451 637 718 572 581 735 331 317 PMC4348149__F1 Signaling-mediated Regulation of MicroRNA Processing 29102 10521 1655 54487 4204 79753 57510 672 27161 23318 79670 1956 PMC4349428__F2 The relationship between genotypes and phenotypes of the nucleotide excision repair pathway and risk of SCCHN 2067 7507 7508 PMC4349561__F3 Pathway analyses of A) tumor protein p53 (TP53) B) E2F transcription factor 1 (E2F1), and C) miRNA 124-1 5310 1029 9618 3475 1869 7157 2237 4174 11201 4602 4605 7153 PMC4349622__F2 Schematic diagram showing the signaling regulation network of LRRC4/NGL-2 in glioma 7852 6774 1017 595 1019 PMC4349729__F2 Simplified view of insulin/IGF1 signaling 3481 3479 3643 2549 5163 2885 2475 PMC4352295__F3 Co-regulation analysis among 6 potential internal control genes (ICGs) 3458 3565 7124 4137 5663 351 203068 6175 5478 60 3251 2353 4613 4609 6722 2959 7157 4204 8932 PMC4352987__F4 Different combinations of transcription factors drive tissue-specific gene expression in immature versus hypertrophic chondrocytes 3091 579 6662 1499 860 4208 3170 864 4209 3171 4086 4090 6660 4087 4088 55553 2626 140628 2627 176 1280 1300 6696 7422 4322 PMC4354890__F1 Causes and Consequences of Replication Stress 84126 545 4173 4176 4175 4174 4172 4171 1652 5111 PMC4360475__F6 Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa 2879 4691 6667 2597 3190 4204 2688 1950 25824 6390 PMC4362528__F8 Human splicing code reveals new insights into the genetic determinants of disease 9743 8120 57447 23416 3908 5536 11188 158067 54825 993 8318 1305 11190 1464 5116 5706 1755 2736 26523 8665 3975 23395 23178 6143 27339 22930 6202 79048 PMC4362832__F1 Endocrine resistance in breast cancer cells 8205 2099 2260 1956 PMC4367189__F2 Signal transduction pathways from the cell membrane to the nucleus discussed in this article 4088 1601 6667 6670 7030 2475 6497 8928 3622 860 PMC4367559__F1 MET/HGF signaling and functional cross-talk with other pathways 3082 1950 7422 1956 2549 2885 126669 6714 238 1499 2475 572 PMC4369647__F2 Signaling pathway associated with CD37 ligation by SMIP-016 4067 6850 951 2932 1499 PMC4369815__F6 Schematic diagram of the signalling pathways involved in DEHP-induced Beta-cell dysfunction 759 83939 468 PMC4370290__F3 Pathways involved to block cell cycle progression 472 545 1021 1019 993 995 994 595 983 1017 PMC4371960__F6 E2-induced signal transduction pathways in the uterine epithelium leading to DNA and protein synthesis 2099 3479 3480 2475 2932 6194 PMC4372648__F1 Three core signaling pathways altered in malignant gliomas 1029 1956 5156 1030 1031 4763 5728 4194 4193 1021 894 1019 PMC4374766__F5 Macrophage Gene Expression Associated with Remodeling of the Prepartum Rat Cervix: Microarray and Pathway Analyses 84329 624 51284 3437 115677 5576 5099 5284 9641 6712 1236 729230 5241 3158 4145 9575 1326 695 100316904 1961 2322 2354 6715 6503 3037 5579 123920 5788 43 4360 5228 4326 79890 1747 8626 3315 115761 4137 23136 3690 5582 388 5341 4147 5054 3059 83706 3695 23650 PMC4375782__F8 Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons 5443 6774 3717 4852 181 PMC4375971__F1 Obesity genetics in mouse and human: back and forth, and back again 3953 7275 4852 181 5443 25970 1363 6774 112609 6492 4160 4159 627 PMC4377021__F10 Relevant crosstalk of altered signaling pathways involved in cell death for PTC and ATC 7076 4312 8828 302 6275 6281 7052 2627 8554 4150 PMC4377021__F5 Pathway for a network related to cell to cell signaling process in the anaplastic thyroid carcinoma 5328 6696 5329 9902 6383 3693 7046 3037 1454 79966 11213 2673 221656 10553 5965 9156 PMC4377327__F6 Regulation of microRNA function in somatic stem cell proliferation and differentiation 5978 4152 388585 55553 5156 22887 6662 10106 5725 PMC4380839__F1 ROCK and Rho 4018 331 6722 PMC4382988__F4 Ingenuity pathway analysis (IPA) of differentially expressed proteins 3240 83483 5630 5004 3866 3848 5054 7498 3497 64167 3872 3851 6242 4146 1520 1404 2331 4060 1634 59 6876 1805 10346 684 6892 3669 5371 9636 51056 4940 51517 1509 25939 51237 3306 29108 8975 5721 5270 51297 92747 PMC4387288__F2 BCL6 targets Tfh genes mainly involved in T cell signaling, differentiation, and migration pathways to drive the GC Tfh phenotype 920 3554 7046 3559 3560 149233 7048 3459 6774 5163 639 6775 2475 6772 6095 30009 3458 2625 6778 50943 1235 604 10365 1236 PMC4388554__F11 Role of Notch Signalling in CD34+ Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL 3280 2932 5728 1499 613 2475 PMC4390087__F5 Beyond Mitophagy: Cytosolic PINK1 as a Messenger of Mitochondrial Health 664 139341 10133 65018 PMC4391119__F6 Schematic summary of findings 3170 2660 2308 PMC4393798__F3 Overcoming T cell exhaustion in infection and cancer 324 3932 7535 10538 PMC4394695__F1 Nuclear distribution of the PI3K pathway 208 10000 207 5163 253430 5728 PMC4394890__F5 MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction 7422 7046 5728 5894 4087 4088 596 4089 4170 4609 1958 6667 3725 1277 717 2624 1278 7528 PMC4396493__F2 No quiet surrender: molecular guardians in multiple sclerosis brain 9817 8452 4094 PMC4397019__F7 Atypical Protein Kinase C Zeta: Potential Player in Cell Survival and Cell Migration of Ovarian Cancer 5590 3690 5578 PMC4398256__F1 MTOR signaling and metabolic regulation 3932 2534 7535 7248 7249 6009 253260 2475 64223 64798 940 PMC4399027__F2 Activation of the MAPK pathway in thyroid cancer 5979 673 10142 55750 7175 4914 2120 4916 PMC4401249__F4 DIANA miRPath analysis of target genes for miRNAs upregulated in AD blood 2891 5567 2907 3845 1387 5579 PMC4401268__F1a Dual role of Cav-1 Y14 phosphorylation: phosphorylat-ed caveolin (pYCav-1) is involved in the control of integrin-mediated signal transduction and caveolae-mediated cholesterol-enriched membrane microdomains (CEMM) endocy-tosis 1445 857 6010 6714 PMC4402595__F2 Relationship between the genes in each module from the GBM dataset 7157 1029 1019 5925 5728 5290 1956 1030 4193 4194 9444 1594 PMC4402634__F4 KEGG pathway map for complement and coagulation pathway 2149 7035 1361 2152 2155 2159 2147 2160 2158 2157 7450 7056 5624 5627 2 5327 5328 5329 2161 5340 3818 5345 718 730 735 729 1431 717 1380 PMC4403492__F1 HPV carcinogenesis 7337 7015 5925 7157 23135 1019 4193 PMC4407294__F1 PI3K/AKT/mTOR and the RAS/RAF/MEK/MAPK pathways 5728 2308 7249 7248 2932 2931 6009 PMC4407294__F2 Molecular pathways regulating breast cancer stem cells (CSCs) 1956 6608 3579 3577 6714 5728 6774 5970 1499 PMC4415581__F7 TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway 57103 1020 472 2539 PMC4417610__F2 Summary of the HGF/c-Met signaling pathway 3082 6714 6774 2549 2885 PMC4419472__F9 Schematic diagram describing the effect of oroxylin A on the inhibition of p53 degradation through the suppression of PTEN-regulated MDM2 expression 23410 5728 4193 PMC4420735__F3 A model of telomerase RNP biogenesis 7015 54433 55651 55505 PMC4422082__F4 CD44- and CD44v-induced RTK for apoptosis resistance 2549 11140 2885 7410 3082 2064 6714 4513 PMC4422099__F2 Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms 7187 4163 11331 142 5245 PMC4422447__F1 Angiotensin II, transforming growth factorB, and Smad signaling pathways 7939 4087 4088 4089 4092 PMC4422811__F2 Survival signaling vs 1956 331 2308 572 596 2309 4303 1950 PMC4424147__F1 Receptor-mediated activation of PI3K-Akt pathway and signaling 613 5728 6850 4067 23035 572 7248 581 6009 2475 2932 2309 PMC4424324__F7 Integrin-mediated signaling pathway that regulates actin polymerization, actin cytoskeleton remodeling, and microcluster formation 3383 3611 998 PMC4425275__F3 Original and reduced EGFR models 1950 4803 1956 4804 5894 PMC4429241__F2 Signal transduction pathways activated by DNA to stimulate type I IFN expression 54106 4615 57506 7706 51135 7189 3654 3665 7186 7188 29110 3661 581 115004 29800 267 PMC4429241__F4 Signal transduction pathways activated by DNA to stimulate activation of inflammasomes and the NFKB pathway 4361 10111 3553 3606 9447 64170 PMC4429241__F5 Endogenous and microbial mechanisms to downmodulate and evade DNA-driven innate immune responses 197358 29110 115004 8408 11277 79065 1777 57506 7706 9447 3428 PMC4431617__F1 Schema of the PI3K pathway 5728 5163 7249 2475 595 PMC4432002__F2 Role of the BM niche in MM pathogenesis 7039 3565 6347 671 11201 6387 PMC4435778__F5 Meiotic recombination 23626 5888 11144 PMC4437509__F5 Downstream components of ERK in SCN neurons 2475 2002 5187 9575 406 PMC4437509__F6 P38 MAPK in the circadian clock 406 9575 8864 1407 5187 1408 8863 PMC4437509__F7 JNK MAPK in the circadian clock 406 9575 5187 1407 8864 1408 8863 PMC4440618__F5 Chlamydia pneumoniae Inclusion Membrane Protein Cpn1027 Interacts with Host Cell Wnt Signaling Pathway Regulator Cytoplasmic Activation/Proliferation-Associated Protein 2 (Caprin2) 65981 324 1499 999 4040 4041 PMC4440819__F7 DA-Raf-Mediated Suppression of the Ras—ERK Pathway Is Essential for TGFB1-Induced Epithelial—Mesenchymal Transition in Alveolar Epithelial Type 2 Cells 2247 4087 59 2335 PMC4441295__F5 Fangchinoline inhibits the growth and invasive potential of gastric cancer cells by inhibiting the PI3K/Akt pathway 2932 4318 4313 1017 581 PMC4445861__F2 Slit/Robo interactions and their roles in carcinogenesis 3082 2932 1499 1630 2885 7852 5266 4318 4313 998 6585 9353 999 PMC4446875__F10 Schematic diagram depicting the conceivable cellular events by which MIOX disrupts mitochondrial integrity under HG ambience, which results in renal tubular cell injury 55586 65018 9927 51024 PMC4449428__F1 TGFB signaling in gliomagenesis and its targeting 7046 4089 6657 3976 5155 6659 3399 3397 1540 5728 3490 PMC4449706__F5 Simultaneous Inference of Cancer Pathways and Tumor Progression from Cross-Sectional Mutation Data 673 3417 1031 1956 55294 324 4763 5156 5288 92 1019 472 2261 1029 5925 5290 7157 6934 1021 5291 5294 5295 3845 5296 5728 4193 5286 6662 4087 4194 4089 2263 5287 546 2260 PMC4451963__F1 Wnt/Beta-catenin signaling pathway 4040 4041 324 607 PMC4452181__F4 Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing 3175 3280 6928 4760 389692 5080 4821 3110 3087 3170 3375 2645 3172 4825 3630 5313 3174 3171 836 50674 4137 3651 348 5078 5663 25825 351 7124 6622 55851 4311 23385 23621 PMC4453439__F1 The signalling pathways implicated in fusion-positive ARMS progression 3481 2264 3480 5728 5077 5081 2308 PMC4454159__F2 Concept map of the cancer metabolic rewiring 26227 3939 6472 10797 11113 4118 27165 2717 PMC4454399__F2 Top Ingenuity Pathway Analysis (IPA) interactome derived from transcriptional regulators found in the Vesiclepedia database 10856 694 283248 8607 2521 6427 55832 10987 4904 3664 5814 10189 4666 4869 9318 4332 PMC4459531__F1 Serrated Pathway to Colorectal Cancer 3845 7157 324 673 1029 4292 PMC4460146__F10 The role of Sag in regulation of KrasG12D-induced papillomagenesis 6295 6500 8454 3845 55914 PMC4461888__F1 p38 MAPK signaling in chondrocytes 627 1386 4208 9759 860 PMC4465084__F1 Investigational approaches targeting the factors contributing to celiac disease pathogenesis 3133 4277 100507436 7124 324 PMC4466442__F2 Pathologic role of TCR, BCR and TH17-induced MALT-1 in demyelination and the inhibition of this signaling pathway by A20 613 8915 5971 10892 1540 PMC4467156__F12 New chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras 2260 2263 2885 PMC4470863__F2 Commitment and maintenance of gonadal cell fate 2254 6736 6662 2099 284654 847 54361 668 399823 PMC4473797__F1 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses 929 4615 51135 3654 3661 3665 PMC4473797__F6 E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses 7098 3661 3665 PMC4475396__F1 REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination 10459 353497 55183 672 324 999 991 PMC4477307__F10 Cooperative disruption of signaling network downstream of mutated KRAS 3845 7074 5879 5900 5058 6654 999 572 1398 PMC4478577__F1 Gut-brain axis for the actions of glucagon-like peptide-1 4201 4922 2922 1803 PMC4478945__F8 Folate- and vitamin B-12–mediated one-carbon metabolism 10797 6472 1757 4524 7298 4548 1719 PMC4480235__F5 Signaling by myeloid C-type lectin receptors in immunity and homeostasis 8844 4046 5894 387 7124 PMC4484411__F1 Genetic/molecular alterations of meningiomas and the signaling pathways targeted 1950 4771 5728 5335 2475 6774 7157 55384 5925 1019 1021 1030 1031 PMC4486424__F6 Ingenuity Pathways Analysis summary 7157 1950 7040 7076 4212 598 9049 841 892 1030 7161 4211 7490 PMC4487780__F1 NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus 23475 130013 952 10135 64802 349565 23057 93100 PMC4489259__F2 Output of a fictitious combination of gene expression and mutations in version of the Calcium signaling pathway modified for illustrating the examples 1128 2774 5566 107 5350 487 7220 773 1139 4638 683 5255 4842 163688 814 23236 2767 5335 1956 113026 51196 89869 PMC4489419__F1 Speculative model of FGF23 gene transcriptional regulation 286 5741 89780 5251 1499 7421 2260 PMC4489880__F5 When pathways collide: collaboration and connivance among signaling proteins in development 122786 4771 4485 9113 26524 1956 6469 PMC4490154__F1 What do we know about the cardiac benefits of exercise? 3084 3479 5728 163732 6418 PMC4490472__F1 Regulation of MAPK, PI3K-AKT, and G2-M checkpoint by members of the family miR-125 and members of miR-let-7c~99a, miR-125a~let-7e~99b, miR-100~let-7a-2, and miR-206~133b clusters in cervical cancer 545 472 79866 6790 998 387 407047 4193 5347 983 5163 2475 28951 PMC4490472__F3 Regulation of JAG1-NOTCH1-uPA, Cyclin D-CDK4/6-p21-p27, and PI3K-PDK1-AKT1 cell signaling by members of the miR-23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR17~92, miR183~96~182, and miR-302s clusters 182 407047 5728 1021 1019 5163 5340 1869 7528 2308 6502 8454 PMC4491123__F2 Targets of miRNAs in different cell types of developing mouse lungs 4851 442912 5934 1026 7074 6469 2002 7171 688 627 4854 57522 85464 120 324 6608 2736 PMC4495315__F1 Signaling via the IGF-1R begins with binding of its ligands, IGF-1, IGF-2, or insulin, to the extracellular Alpha-subunit, and this in turn leads to phosphorylation of the intracellular Beta-subunits 3480 3485 3489 3488 3486 3484 3487 3479 3481 3667 2885 5728 5163 572 7249 3725 2353 PMC4496222__F7 Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development 1956 2885 2549 PMC4502937__F8 Schematic representation of the molecular interactions following macrophage and cancer cell activation 1436 729230 7291 7099 PMC4504428__F2 MDM2-p53 Pathway in Hepatocellular Carcinoma 619501 6722 1316 4193 23410 3621 PMC4511109__F3 Live to die another way: modes of programmed cell death and the signals emanating from dying cells 197259 7186 8717 8737 1540 8772 11035 841 836 840 7187 PMC4511781__F1 Insulin and IGF-1 signaling in gray mouse lemursIR and IGF-IR share a similar signaling pathway which invokes downstream changes in two main branches – the mitogenic pathway (Ras/Raf/MEK/ERK) and the metabolic pathway (PI3K/Akt) 3479 3480 3667 5163 5728 2932 7248 7249 2475 6194 PMC4511863__F1 Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease 3929 3458 23643 4615 7189 10454 3659 PMC4512830__F6 Examples of IPA software outcome: hsa-let-7 and their target genes in Human Embryonic Stem Cell Pluripotency Pathway 1386 2353 3725 100188835 6667 1356 PMC4514171__F1 TLR diversity, ligands, and signaling 7097 10333 7096 7099 114609 4615 3654 51284 54106 7098 7189 29110 PMC4514860__F1 Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway 2335 324 4089 4088 25805 50964 6500 8454 387 9475 PMC4516432__F5 Models for pre-miRNA uridylation by TUT7 Pre-miRNA uridylation by TUT7/4/2 in microRNA biogenesis pathway 27161 79670 23318 PMC4516463__F1 Signalling pathways involved in skeletal muscle remodelling and atrophy following disuse 3479 3667 4087 4088 2475 2021 581 717 PMC4516482__F7 The hypothetical mechanisms involved in fibronectin-induced P2X4R up-regulation in microglia 4067 1977 4193 PMC4519954__F12 Lysosome signaling pathway 3425 2548 2990 4669 4668 2581 2588 2799 3423 175 20 51172 PMC4520755__F1 Canonical Notch signalling pathway and relevant pharmacological inhibitors under development in cancer 10683 28514 54567 3714 182 9794 4609 1026 896 441478 PMC4521272__F1 Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response 3466 3454 7098 51284 3665 3661 3441 PMC4521418__F3 Brca1 pathway is involved in microglia from hSOD1G93A mice 545 472 5932 4800 891 1869 2099 6772 466 7015 25859 7508 1643 5111 3479 7422 3458 672 675 4436 595 PMC4523214__F1 Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma 613 930 5728 4067 6850 695 5336 4193 2932 2475 PMC4523434__F1 Endoplasmic reticulum quality control in cancer: friend or foe 10956 6400 7494 PMC4524513__F1 Tendon Mechanobiology: Current Knowledge and Future Research Opportunities 9049 23440 1003 1674 1311 847 PMC4527420__F1 A simplified representation of endocannabinoid synthesis and degradation pathway 5091 747 221955 2166 4513 PMC4528065__F7 Model of CC-122 costimulation of T cells and tumoricidal activity through degradation of Aiolos and Ikaros 51185 1642 3665 3558 PMC4530213__F5 Functional connections brought by the active clusters between T2D and obesity 8503 8651 5578 1956 2057 1438 5781 1399 3718 5747 867 5618 8660 7297 2885 1147 10818 3953 4916 5590 7529 4089 3977 1271 5595 3569 3643 2353 6932 3725 7329 6934 PMC4530250__F2 GDF-15 regulates signaling pathways essential for cardioprotection 238 1956 4091 4092 1499 572 PMC4530463__F1 Basic biology and role of interleukin-17 in immunity and inflammation 7124 84818 7189 7188 7186 23118 257397 10682 PMC4537205__F5 Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway 5228 3479 6009 5728 3667 10670 51719 5594 6794 5170 2475 5562 54541 208 3091 7249 7248 7422 6195 6199 5579 5515 1975 6194 8661 1973 1981 1982 1978 9470 PMC4538325__F3 Signaling pathways modulated by electrophilic lipids 4094 3297 9817 8452 PMC4539294__F2 Schematic of the itch spinal cord circuit.The initial stages of the itch-circuit in the spinal cord are characterized by the expression of neuropeptides and the post-synaptic expression of their cognate receptors 2922 4879 4881 83737 6750 PMC4540474__F6 HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation 9025 23118 257397 10454 PMC4541793__F1 ANTI-TGF-ß THERAPY IN FIBROSIS: RECENT PROGRESS AND IMPLICATIONS FOR SYSTEMIC SCLEROSIS 4092 4087 4088 85451 PMC4545213__F4 Mammalian molecular clock and oscillation of mRNA and protein in peripheral tissues 1408 26224 406 9575 8864 8863 1407 PMC4546439__F2 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened 6657 79923 355 596 472 4318 4313 999 6935 PMC4546755__F2 Overview of ROS-mediated NRF2 activities 9817 8452 7295 407024 1728 PMC4546937__F3 COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING 3718 3716 8651 6778 5163 7249 7248 6009 64223 64798 9655 9021 PMC4547013__F1 Network of miRNAs and target genes in OS 3480 1956 387 5728 6093 6774 51514 406988 1869 23314 860 4609 1871 PMC4547750__F4 Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases 2475 1843 1845 11072 1849 993 994 7124 56940 995 PMC4548922__F2 Decreased fatty acid oxidation contributes to CKD progression 948 7040 4088 PMC4550852__F7 FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes 2167 2475 316 PMC4552638__F8 Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway 7249 7248 1977 PMC4554190__F3 Illustration of data-enhanced Bayesian network inference 6654 4893 5604 5594 367 354 PMC4555477__F1 Some sphingolipid fundamentals 95 64781 4026 PMC4562633__F4 Discovery of Intermediary Genes between Pathways Using Sparse Regression 10577 2896 51246 2745 3934 629 3959 10544 567 57097 23011 9636 128866 8460 79751 6631 5686 9961 5721 91147 6238 91543 841 9111 3433 3431 6891 8546 57194 8914 22875 55002 10948 6373 5525 6892 5698 10392 3964 4332 4343 388646 84888 4524 129531 64761 1633 6890 64127 837 7419 10890 7408 10981 3720 64386 5597 7142 3383 5001 80228 83931 11021 474382 117178 10363 51100 PMC4563160__F8 FASN inhibition blocks metabolic and signal transduction pathways vital to cancer cell growth, proliferation, and survival 2475 1499 2194 6194 4609 4040 PMC4563985__F4 Mechanisms of NFKB-mediated diseases 64127 331 79092 8915 8767 10892 57506 23118 257397 3661 PMC4564160__F3 SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells 272 3857 26278 2109 9729 2521 811 8925 6311 8505 7184 3329 3313 PMC4568771__F1 The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper 4040 4041 324 607 PMC4568949__F5 Non-invasive prognostic protein biomarker signatures associated with colorectal cancer 5284 920 9902 3105 3075 2335 23705 1356 116844 7448 2266 2153 PMC4571436__F2 CXCR3 Isoforms play functional roles in seemingly opposing directions 4283 6714 9021 3717 571 6774 4170 PMC4571863__F11 Model showing that KLF17 suppresses cancer metastasis via a p53-dependent pathway (a) and showing that a novel positive feedback loop exists between p53 and KLF17 (b) 128209 999 7431 PMC4577049__F1 Up-regulation of the inflammatory response biofunction in Rwandan adults during mild malaria compared with day 30 of convalescence 712 713 11006 29126 4318 8542 30009 10859 133 959 7096 3240 2207 3868 7052 29121 1178 1869 3578 4603 133746 6272 9935 353514 51338 26278 3717 PMC4579870__F2 Core UPR pathway and its modulation on autophagy 468 83939 9474 7249 6009 2308 8408 9776 7186 22926 1612 9706 PMC4580256__F1 PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma 5163 5728 2475 PMC4580488__F10 A schematic diagram showing the proposed signaling pathway underlying the regulation of ovarian cancer progression by HBEGF/EGFR/YAP/HBEGF and NRG1/ERBB3/YAP/NRG1positive feedback autocrine loops 10413 1956 2065 1839 3084 9542 PMC4580722__F1 Autophagic machinery 8408 60673 9776 5289 55626 22863 30849 55062 26100 53917 3920 PMC4581028__F1 Regulation of cell metabolism by proto-oncogenes and tumour suppressors 5728 6009 7249 4193 4609 7157 PMC4582117__F8 Schematic of the VEGF-A/NRP1 signaling pathway to promote cancer cell proliferation 8829 10755 387 PMC4585638__F3 ‘Obesity’ is healthy for cetaceans? Evidence from pervasive positive selection in genes related to triacylglycerol metabolism 31 948 2169 23305 51703 2167 2806 2172 1149 150763 8443 51085 4018 6721 4099 11343 80168 5091 5140 23007 5330 84812 51196 5332 9651 5336 89869 84649 9792 PMC4586096__F1 G2E3 attenuating replicative stress 55632 545 5111 56852 PMC4589488__F3 Schematic view of bench-to-bedside aspects of colorectal cancer epigenetics 7431 652 3676 1029 999 6596 7078 3400 3394 6422 160728 6423 1012 4292 407009 PMC4590647__F7 rLGALS9 internalization and signaling in CRC 5604 9474 5894 8678 PMC4590661__F3 Regulation of autophagy by the MTORC1 signaling pathway in cancer cells 8140 6510 2744 2752 472 2746 7249 7248 7942 10670 10325 64121 58528 9821 60673 8408 8878 9776 PMC4590996__F2 Biomarkers of primary open-angle glaucoma 3929 7189 29110 3661 960 7099 4615 929 PMC4591923__F1 Peptide vaccines and peptidomimetics targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy 7422 7039 100187907 3791 1956 2885 2475 PMC4591983__F5 Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula 150353 9020 10537 4883 4072 9421 332 4317 3641 7124 3603 PMC4591983__F6 Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula 2035 26280 407020 2902 5617 9971 7857 7020 6772 6774 4513 PMC4594952__F3 Concise review on the current understanding of pancreatic cancer stem cells 6469 22943 324 2932 1499 960 4072 3280 79923 2305 6657 2737 2736 PMC4595210__F4 Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice 5605 57561 1356 3280 1959 1960 84706 136 PMC4599194__F1 Schematic model of MIF pathways in breast cancer cells (BCC) 4282 972 7852 PMC4606200__F1 Programmed death-1 causes T cell exhaustion 7535 7297 3716 6773 6772 10379 PMC4608686__F6 Equivalent Gene Expression Profiles between Glatopa™ and Copaxone® 6778 324 3593 3109 23308 3606 8809 2833 3559 1232 1233 8807 3566 3561 1380 3627 6281 3458 4615 6775 2625 7124 246778 PMC4609742__F9 Model depicting the functional interplay between PPM1G, the 7SK snRNP, and ATM kinase during the activation of the NFKB transcriptional program in response to DNA damage 472 11201 5496 56257 51574 PMC4612381__F6 Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging 22926 83939 7494 2923 9695 468 3569 PMC4613246__F1 PI3K/AKT signaling pathway 5163 5728 7249 572 PMC4613246__F2 AKT-independent PI3K signaling in cancer 5163 695 5728 23678 PMC4613493__F2 Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism 4190 4199 2194 PMC4613848__F1 RASSF1A/LATS1/CDK2 pathway upon fork stalling 545 84126 675 9113 1017 5888 7486 641 PMC4613848__F2 RASSF1A regulation of the Hippo pathway in response to DNA damage 472 545 4485 5894 9113 10413 1017 PMC4614341__F1 Schematic of signaling pathways involving the DNA damage response (DDR) pathway in apical and basal cells in the developing neuroepithelium 545 472 4193 PMC4614629__F1 Schematic illustration of the targets of actions by spermidine in different pathways 2475 10533 100187761 PMC4614871__F3 Different regulation of DSB repair pathways in somatic cells and XY body 472 3014 545 165918 9656 11073 9025 672 56852 5888 51199 PMC4615895__F6 The model for effect of miR-214 on osteoclastogenesis 5163 5164 5728 PMC4620423__F1 Core signaling pathways in embryonic stem cells and cancer stem cells 4838 3976 4087 4088 4090 4086 2549 6774 4089 1499 324 983 2353 6608 5727 51684 2735 2736 648 3977 PMC4621122__F8 Hypothesized model for E4-ORF1-induced constitutive Myc protein expression mediated by EGFR, InsR/IGF1R, and PI3K 1739 2475 4609 3480 3643 1956 PMC4621609__F10 Schematic of a proposed model for GLP1-mediated signaling pathway protecting cardiomyocytes from PA-induced lipotoxicity 948 1499 596 PMC4621888__F1 Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder 3815 9846 5879 387 5058 6093 6772 6774 171023 1788 54790 PMC4621929__F3 STRING network analysis reveals a database of known and predicted protein interactions 390 6093 84465 4175 92737 81624 8153 1954 29128 10460 1729 202559 11194 11153 163126 58504 2004 4094 51176 9325 84174 1952 2975 4087 2033 1953 2 57658 54971 7157 3937 207 8445 6714 2783 57663 1950 5294 10153 868 5243 9855 1793 1956 3716 1955 2059 23636 1244 5332 85015 4650 PMC4622872__F3 Epigenetic regulators as central components in melanoma signaling 673 1021 1019 1029 1788 1789 9055 3065 2475 PMC4626744__F4 PGE2 synthesis, action, transport and metabolism in granulosa cells 6578 9536 3248 5743 5321 PMC4628872__F1 The canonical and noncanonical regulatory pathways of Nrf2 signaling 9817 4094 2730 10533 9474 PMC4629125__F1 Intrahepatic interplays among hepatocytes, non-parenchymal cells (NPC) and lymphocytes and illustration of antiviral and immunotherapeutic strategies 7098 4615 114609 29110 3661 1386 3458 3460 3459 3454 3455 3716 3717 7297 10379 PMC4631973__F1 PI3K/PTEN/Akt/mTOR-cascade (Modified according to Cingarlini et al and McCubrey et al) 3479 3667 5728 7249 7248 6009 64798 64223 PMC4633914__F1 Functions and interactions of CIP2A and the “oncogenic nexus” of CIP2A are presented in a schematic representation of the major interacting partners of “oncogenic nexus” of CIP2A protein 57650 5518 2308 207 4193 PMC4636403__F5 Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells 1356 3827 2266 5054 1718 2948 4599 2161 5340 5345 2152 2158 2153 7450 2157 7035 2159 2147 2 PMC4637293__F1 Anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients 10538 6774 2308 2475 PMC4638384__F1 Inhibition of YAP/TAZ transcriptional coactivators by LATS1/2 4485 60485 9113 9686 7003 8463 7004 7005 PMC4641524__F4 Differential Somatostatin Receptor (SSTR) 1-5 Expression and Downstream Effectors in Histologic Subtypes of Growth Hormone Pituitary Tumors3.1 6752 6714 9049 2002 PMC4641903__F2 Summary of the roles of alpha-synuclein and other PD-associated proteins in the secretory pathway and the resulting stress responses 5861 81876 5864 120892 22926 7494 9529 2580 378 1020 8766 65018 PMC4643662__F3 The role of S100 proteins and their receptor RAGE in pancreatic cancer 6275 6277 6469 2735 6273 PMC4644426__F9 Syncytin-1 alterations triggered placental trophoblast cell cycle changes 1019 1869 983 PMC4644734__F1 Steps in the macroautophagy pathway 22863 8408 2475 55054 10533 PMC4649380__F5 CTGF Signaling Network ModelWe compiled a list of molecules known to be associated with hematopoiesis () and reported to interact directly or indirectly with CTGF and each other using EXERBT text mining and Pathway Commons, respectively ( and ) 6502 2033 4087 4088 4089 7040 7042 7043 7048 7157 1869 1026 1027 1956 2308 898 9134 1017 3482 3685 3690 595 5728 1021 1019 1499 2353 7976 8323 8322 7855 8324 2535 8321 11211 8325 4041 4609 2932 PMC4650429__F1 During normal cellular conditions, BRD4 recognizes acetylated lysine residues on histones and recruits positive transcription elongation factor b (P-TEFb) to promote transcriptional elongation by RNA polymerase II of key oncogenic drivers such as MYC 23476 4609 1499 PMC4651023__F4 Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation 5970 3725 2353 4089 PMC4651738__F8 Schematic diagram illustrating the proposed signaling pathway 9896 7124 4353 PMC4654378__F2 NOX system is central to host defense 50507 27035 3550 64127 50506 4693 7412 3383 114548 3553 PMC4654680__F4 Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer 4771 4485 1499 9113 26524 PMC4655250__F2 Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment 4157 5728 673 467 4286 468 2475 PMC4657734__F2 Smad complexes can cooperate with transcription pathways in the control of gene expression in epithelial-mesenchymal transition 6469 6608 2932 4087 4088 2735 27040 4089 1499 3516 9839 6935 2303 3169 3170 PMC4661210__F3 Activation mechanism of NRF2 and downstream transcription events 9817 140809 2052 2729 2730 3162 1066 1728 4835 8714 368 1244 10257 9429 PMC4661210__F6 Activation mechanisms of the ASK1 signaling pathway leading to JNK and p38MAPK phosphorylation 7124 2353 7186 7188 7189 PMC4661875__F2 Intrinsic and extrinsic apoptotic pathways: The intrinsic, or mitochondrial, pathway is initiated from within the cell in response to DNA damage, loss of cell-survival factors and severe cell stress 56616 8837 8717 355 8772 PMC4663505__F7 Drug target prioritization by perturbed gene expression and network information 27076 54361 7490 9314 8660 1385 602 5328 5728 4088 133 10252 1956 4790 5468 4609 9536 5743 3725 7032 7124 7042 3714 123 388 581 54509 PMC4665079__F6 Autophagic signaling pathway 9140 596 10533 83734 9474 8408 9776 64422 55014 9342 8673 3920 3916 PMC4666507__F1 Described mechanisms involved in steroid hormone regulation of cancer stem cell populations 367 9314 1956 2625 2254 604 4853 182 6926 PMC4667854__F2 Molecular events involving IRFs in immune responses 7099 6772 10379 7098 54106 51284 3662 4615 3394 7189 3663 3659 3665 3660 51135 PMC4669118__F9 Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway 8826 998 23229 PMC4669123__F1 Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish 84649 2194 51 PMC4669196__F3 Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms 55601 51428 115004 3428 3661 57506 3553 54106 170506 1660 9447 4615 PMC4671844__F1 Molecular pathways leading to CRC 4292 673 4436 2956 5395 3845 324 PMC4673119__F1 Regulation of T follicular helper cells by ICOS 29851 2308 1901 6402 6404 1236 30009 PMC4673190__F1 The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer 545 472 4193 581 PMC4676710__F3 And B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) response in C3(1)-T TNBC mouse model samples collected before palpable tumor compared with baseline, based on Ingenuity Pathway Analysis 6427 6282 7012 7157 23321 4800 5702 10763 2101 6814 PMC4681408__F6 Patient-specific Immune States before Surgery are Strong Correlates of Surgical Recovery 3146 929 6194 9261 5970 7099 PMC4685484__F6 HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction 3146 114609 4615 51135 PMC4689162__F1 Beclin-1 interaction complexes Atg14L and UVRAG/Bif-1 activate the Beclin-1 complexes and induce the formation of autophagosomes in a mutually exclusive manner 23118 10454 3146 55626 81671 7405 7189 8975 PMC4689162__F3 Autophagy and some of its regulatory pathways Binding of insulin or growth factors to the insulin receptor triggers the PI3K pathway, converting PIP2 into PIP3 that recruits PDK1 and Akt to the plasma membrane 5163 3667 7249 7248 6009 9140 9474 PMC4695870__F2 Melanoma cells develop resistance to MAPK inhibitors by mutating (mut) or altering expression of a number of proteins which reactivate MAPK signaling and/or activate alternative survival pathways such as the PI3K pathway 9682 27022 4763 673 2186 2146 1956 558 3082 3084 PMC4700483__F5 MYC splicing connections in cancer 2002 4609 4149 5725 6426 3178 4193 595 PMC4700624__F2 Changes in the representation of IGF-Akt pathway 3479 3480 5163 7248 7249 6009 6198 PMC4701050__F3 Origin and in vitro generation of eCPCs 4838 3671 3670 90525 55897 3791 5154 22943 2626 4208 PMC4702319__F1 CagA mediates dysregulation of the Wnt/Beta-catenin signaling pathway 999 4040 1499 324 7008 2932 PMC4705549__F5 Multiple functional linear model for association analysis of RNA-seq with imaging 64925 4724 100423042 8858 11162 6433 746 9553 PMC4706689__F1 IL-10 and integrin signaling pathways are associated with head and neck cancer progression 3684 3696 7057 3674 2243 3687 83700 2335 7448 2266 3689 3693 6696 3690 3681 2244 80781 3685 1311 375790 3679 PMC4707207__F1 PI3K/Akt pathway 5163 5164 3667 5728 2932 7249 6009 2475 10018 1027 PMC4709767__F6 Proposed pathways by which NRG-1 stimulates GSH synthesis and Cbl metabolism 3084 867 5266 PMC4712384__F4 Evasion of innate immunity by HCV viral proteins 7297 7098 6772 6773 9021 57506 4615 29110 3661 83939 7187 PMC4713888__F1 Immune evasion mechanisms seen in acute leukemia.Multiple immune pathways and functions are targeted by acute leukemia 6774 920 3902 100507436 PMC4715161__F2 Transforming growth factorB (TGFB)-activated kinase 1 (TAK1) activation by TGFB in mesangial cells 7189 23118 4087 4088 4091 4092 10454 4089 1386 PMC4716037__F1 Deregulation of Hippo pathway in gastric cancer 4485 9113 26524 10413 9686 7003 8463 7004 7005 PMC4716086__F1 Homeostasis and epidermal growth factor receptor downstream signaling pathway in keratinocyte 7039 2069 374 1839 1956 2885 PMC4718179__F4 Activation of EGC and induction of a reactive EGC phenotype 2670 6285 6662 30812 6663 941 942 2668 5465 PMC4721243__F3 DDN, (b) GDNMES, and (c) GDNnon-MES of Integrin AIIb B3 signaling (M760) pathway 6464 10411 10125 10235 2244 1398 1445 2885 11069 5747 54518 3690 5170 6654 6850 2243 5906 5770 6714 9564 2266 7094 23109 PMC4721243__F4 DDN, (b) GDNPN, and (c) GDNnon-PN of PI3K events in ERBB2 signaling (M570) pathway 1385 10000 3084 2065 9542 2885 117145 842 1027 1839 1950 1956 1147 2549 4303 5728 2309 2069 253260 7249 572 3164 2064 6199 1026 4193 2931 5290 2066 23109 PMC4724176__F2 Molecular signaling and the advantages of Warburg 3082 1950 5728 3099 5170 7249 7248 6009 5163 3091 1977 PMC4725600__F1 Mdm network and its regulation of p53 activities: a rheostat of cancer risk 10111 4361 4193 4194 4609 PMC4726088__F9 Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1 2066 627 3084 5662 PMC4726449__F5 Identification of Symptomatic Fetuses Infected with Cytomegalovirus Using Amniotic Fluid Peptide Biomarkers 3045 100187828 23513 7249 4175 4118 759 567 761 9370 PMC4726471__F2 Interplay Between Centrosomes and the Hippo Tumor Suppressor Pathway 60485 4485 9113 26524 4193 PMC4727405__F4 Screenshot of CNV and splicing representation 207 2475 572 PMC4730127__F3 Targeting of the genes and pathways for stem cell maintenance by miR-200 family miRNAs 1499 182 648 9839 6935 84441 55534 999 PMC4731262__F1 Wnt/Beta-catenin signaling in kidney injury and repair: a double-edged sword 4040 4041 23002 2932 324 6010 1499 998 PMC4731439__F2 Interaction of proteins involved in signal transduction via the TNFAlpha-related signal transduction pathway (based on http://string-db.org, simplified) 5045 10454 1896 23118 7316 7189 1540 60401 PMC4733614__F4 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies 324 940 941 3458 5009 PMC4734073__F4 Strategies evolved by Staphylococcus aureus to counteract innate immune response 2921 3579 2358 7097 102 3383 718 85477 727 PMC4734217__F1 Pim-1 kinase as cancer drug target: An update 8651 9021 1977 6774 7249 572 4609 4772 5292 5970 11335 596 995 993 PMC4736325__F2 Synaptic binding partners and signaling pathways of BAI adhesion-GPCRs 389941 338761 10882 165257 3045 100187828 4193 7074 6010 5879 PMC4737482__F1 Network mapping of genes with >5-fold expression change using IPA 4665 4751 2022 1874 1634 638 597 2118 5970 3627 PMC4739352__F9 Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90 8567 8737 8717 3479 572 637 317 PMC4741479__F4 Radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas 8243 472 1019 595 1021 6667 4193 4602 2321 7157 7422 4170 596 3791 1026 959 7490 1788 27250 1789 PMC4741750__F3 Down-regulation of IKKB expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma 5601 6416 6351 1432 10454 4790 3627 6885 4792 958 7100 51135 2920 7189 51284 4615 941 7187 5293 5291 5290 PMC4742192__F10 Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer 83939 581 468 842 836 PMC4742785__F4 Working model of an integrated axon degeneration signaling cascade 84937 207 23098 23057 PMC4743122__F1 Schematic illustration of the mechanisms impairing VEGF-A/VEGFR-2 angiogenic signal in SSc 2313 8829 4035 7422 PMC4745409__F2 Pathways involved in internalization and sensing of dsDNA 3146 613 54106 4615 9447 7189 7187 29110 57506 3665 3661 3603 PMC4746893__F1 Cyclin D/cyclin-dependent kinase (CDK)4/6/retinoblastoma (Rb) Pathway and the cell cycle 595 1017 1021 1019 983 PMC4747358__F3 Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine 553 4543 85451 6707 4609 1499 8484 5626 122042 7107 PMC4748038__F2 Shigella exploits Ca2+signaling to delay cell death and to dampen inflammation 581 1647 664 10392 331 836 837 PMC4754448__F1 Actin associated proteins regulate YAP activity 4018 4771 4485 6010 1499 9113 26524 10207 154796 5728 7003 8463 7004 7005 PMC4755325__F1 CGAS-STING Defense Pathway and Its Counteraction by Viruses 115004 9447 4615 57506 3661 PMC4755889__F3 Interconnections between the Hippo and RB/E2F pathways 4172 4175 983 5422 9113 26524 993 91750 990 4173 860 5928 PMC4762423__F1 Metabolism reprogramming in PDAC 2805 4199 6120 22934 3845 2673 4609 3939 3098 PMC4762514__F4 Metabolic pathway alterations in PCT 10135 1757 27232 4860 4548 875 191 55349 3099 55217 132949 64841 55577 501 10157 5238 8473 PMC4762924__F1 Key pathways of glycogen synthesis and metabolism 2998 2997 5834 5836 5837 256281 178 5236 PMC4763866__F1 Schematic pathway of SOCE in neutrophils, leading to activation of the NAPDH oxidase 84876 80228 93129 6786 57620 PMC4766172__F1 Lysine degradation pathways in mammals 10157 51268 55526 51166 1892 2639 10449 3033 PMC4766464__F9 Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis 581 468 83939 PMC4766714__F9 Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice 1356 874 57491 26298 1999 6364 7124 718 8842 3934 5196 2920 929 6374 6367 56477 284340 PMC4767244__F2 NFKB activation pathways 958 4055 5971 472 545 PMC4767244__F3 NFKB signaling by oncogenic pathways in GBM 1956 9253 2549 4763 1540 5728 472 51147 PMC4767381__F2 The canonical pathway of miRNA biogenesis and the mechanisms of miRNA controlled posttranscriptional gene regulation 27161 29102 7054 PMC4768070__F2 BST‐2 in viral infection: BST‐2 tethers viruses to the cell membrane and to each other (1) and (2) 5132 6955 10454 23118 684 920 PMC4771656__F7 Signaling pathway of SFN in U251MG cells 2810 999 572 596 581 PMC4772163__F5 Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm) 10268 5020 8877 1644 85358 5603 4638 4208 PMC4773745__F1 Inhibition of components of the Shh Pathway in cancer 6469 51684 55733 5727 4609 6657 79923 PMC4777597__F1 The 5S RNP complex (RPL5, RPL11 and 5S rRNA) regulates MDM2-p53 in response to cellular stress 6125 6135 4193 PMC4778065__F9 Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases 367 2869 10014 PMC4779708__F1 Schematic model of signaling pathways implicated in tumor cell vascular mimicry (VM) 4838 1003 4855 6714 960 4087 4088 1969 7291 6657 4323 7018 PMC4783232__F1 MicroRNA deregulation in cancer cells and the tumor microenvironment 2002 2113 4609 29102 54487 7403 23135 1956 27161 PMC4783980__F2 Inhibition of Calcium-induced T Lymphocyte Apoptosis pathway 920 5335 824 23523 4209 PMC4786834__F1 Linkage between the mechanisms of thrombocytopenia and thrombopoiesis 7173 4352 4351 2313 10661 PMC4788539__F7 Schematic model recapitulating the role Shoc2 plays in controlling ERK1/2 activity 1950 8036 3959 PMC4788585__F8 The EGF Receptor Ligand Amphiregulin Controls Cell Division via FoxM1 374 1956 595 2305 PMC4790586__F5 Signaling cascades through Twist and their roles in carcinogenesis 6774 1000 999 100133941 2303 6935 PMC4793894__F3 PPAR signaling pathway 3158 2167 948 335 10998 116519 336 5360 345 5465 6256 4199 9415 6319 1581 10062 1582 1593 2168 1622 2170 10999 4023 5467 4973 2180 1376 6342 33 34 51 5346 51129 5468 9370 7350 3611 5170 7316 5105 364 PMC4794722__F2 Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia 10891 3988 1579 37 51141 3030 34 440503 5465 3033 8431 2101 9992 338 1376 2108 35 2109 2110 5660 5019 55670 PMC4797117__F2 ML-hGRN for putative pluripotency renewal pathway in human embryonic stem cells 5015 2521 5978 7546 5168 7547 10346 63978 55211 6774 6498 4801 5090 6418 51157 10389 23528 4976 10153 2963 PMC4798945__F7 A model of the tumor suppressive functions of TGM2 in HMECTERT/ST/ER-RasV12 cells 7157 1026 7052 8678 8878 9474 9140 PMC4800799__F7 Model depicting the proposed effect of starvation on microRNA in cancer cells 5337 5338 5091 406958 100500828 100126347 PMC4800996__F2 Serine biosynthesis and utilization 2731 29968 26227 5723 6472 6470 PMC4801467__F1 Mechanisms and immunotherapeutic targets for glioblastoma (GBM) 3586 196 405 3620 29110 3661 3665 920 50943 PMC4802755__F1 Schematic depiction on exogenous LIF mediated intra-cellular signaling pathways for robust self-renewal in mESCs 3976 3977 6774 79923 6657 PMC4803136__F1 The biologically relevant candidate genes selected in this pharmacogenomic study 6573 2356 8836 3558 1719 7298 471 4522 4524 6470 7361 1915 135 PMC4803799__F3 mTOR in sensing autophagy signals : mTOR inhibition integrates amino acid starvation, growth factor deprivation, decreased ATP or oxygen levels, enhanced reactive oxygen species (ROS) to activate autophagy 7249 7248 3091 6009 664 8408 7942 PMC4803799__F7 Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches 51024 55669 55349 55486 9958 84749 65018 9101 9530 55626 23098 3305 7189 25793 54543 57154 664 139341 PMC4805534__F7 Schematic illustration of GSK3B/eIF2BE and mTORC1 signaling in AKT-induced CNS axon regeneration 5163 5728 7248 7249 2932 1998 1977 PMC4808028__F9 Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism 2335 7939 4052 PMC4808242__F1 Obesity-linked metabolic pathways susceptible to diet induced epigenetic perturbation 1788 7054 6531 1028 5443 7903 8932 1786 4204 3952 4837 1050 5468 2194 9869 PMC4808796__F1 ATM, ATR and DNA-PK signalling pathways 545 472 9656 4361 7518 84126 9025 165918 672 11073 PMC4809369__F2 LIF/JAK/STAT3 signaling pathway in mouse ESC self-renewal 3976 2885 6774 2637 5292 6926 9021 79923 6657 PMC4809369__F3 Canonical Wnt/Beta-catenin signaling pathway in mouse, rat and human ESC self-renewal 4040 4041 324 1499 999 1044 6929 51176 79923 2103 10365 1045 PMC4809369__F4 FGF signaling pathway in mouse, rat and human ESC self-renewal 2249 2885 2549 2932 79923 10818 PMC4809875__F1 Reelin signaling pathway in adult synaptic plasticity 7436 1600 2534 2475 2932 PMC4810982__F1 Proposed scheme for the protective effects of linagliptin against ABeta-induced neuronal insulin signaling blockade.GLP-1 is synthesized and secreted by neuronal cells 1803 23411 2932 PMC4811021__F1 Diagrams of the Hippo signaling pathway in (A) Drosophila melanogaster and (B) mammals highlight the core kinase cascade and upstream regulatory signals 60485 4485 9113 PMC4813427__F6 Summary of NOP receptor signaling 156 157 407 PMC4814460__F1 Autism spectrum disorders (ASD) candidate genes cluster into functional networks, and the two most prominent are synapse structure/function and protein translational control 1600 7249 7248 6009 2475 PMC4816186__F6 Notch 1 signaling pathway and proposed mechanism of action of CJ 102 4609 4791 30001 581 PMC4816188__F1 TP53 pathway in CLL 25913 6209 472 545 330 4193 7157 PMC4819564__F2 Signaling cascades of Cripto-1, Notch/CSL, and Wnt/Beta-catenin 1499 6997 1950 4838 8650 324 64840 4087 4088 6714 4089 607 5045 PMC4822708__F4 Functional crosstalk between CD36 and CD47 signaling 961 948 6714 PMC4822708__F7 CD47 regulation of autophagy 961 10533 9474 PMC4823950__F1 NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells 4803 4170 8772 637 331 836 842 PMC4824625__F4 A-to-I editing of coding and non-coding RNAs by ADARs 103 29102 5631 PMC4826512__F4 Targeting of the axonal guidance signaling by Tat altered miRNA 5829 100187761 7852 29984 2534 157313 6383 2242 9855 27289 1977 1398 PMC4833475__F1 Insulin Signaling and Heart Failure 3479 3667 8660 5170 596 207 208 7249 7248 948 2475 2932 8408 1977 PMC4833964__F1 Cancer-relevant pathway map 1499 2475 207 PMC4834478__F8 microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling 6772 6774 581 PMC4835495__F2 Control of the FA pathway by SUMO and SUMO-like modifications 6047 51455 84126 545 55215 2177 26054 7398 84464 8554 165918 2067 5111 672 PMC4835942__F1 Ca2+-mediated regulation of autophagy in the heart 9474 8408 2475 7942 3479 846 PMC4835965__F4 ER stress and autophagy in AD 7276 1191 3309 4137 2081 9451 22926 1965 643246 2932 619537 1476 1508 3553 8678 114548 PMC4836034__F1 Autophagy pathway and its interaction with HSV-1 8408 9706 8678 8878 29110 83939 9711 5499 5610 7405 PMC4838159__F1 Five significant subnetworks of the N-group, associated with (A) glutathione metabolism (B) leucine and isoleucine metabolism (C) pancreatic cancer (D) calcium signaling pathway and (E) the mitogen-activated protein kinase pathway 2946 3030 2950 4790 7422 51060 3028 4258 3033 6774 4257 5228 65985 2878 5879 9459 9446 3155 1892 2941 3309 5597 5532 805 1398 1843 5530 801 6197 1848 808 PMC4838297__F6 Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells 2539 7186 8717 4513 PMC4841296__F1 Main molecular mechanisms affected in malignant megakaryopoiesis and platelet function defects 7173 4352 2623 4602 2313 2815 861 4778 10398 4627 4628 81027 595 3717 PMC4846185__F7 ARF1 in mediating gefitinib sensitivity in breast cancer cells 1956 558 375 6714 PMC4848008__F3 The HA/CD44 signaling pathway leading to the malignant phenotype of cancer cells 960 79923 6774 6657 595 27250 PMC4849794__F7 Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson’s Disease 4942 6772 3725 1874 6878 1674 PMC4850137__F1 Reactions induced by IL-10 914 100187761 1147 31 4792 5970 2475 4846 389692 PMC4850140__F1 Tested Wnt-related genes and proteins and their functions in the canonical Wnt signaling pathway are shown here 4040 4041 324 PMC4854877__F2 Dynamic angiogenic signaling balance and angiogenic switch 948 5335 2534 5310 4018 PMC4855676__F5 Regulation of the apoptosis signaling pathway by NFAT proteins 627 51127 637 581 56616 790 220042 PMC4856760__F8 Working model of the regulation of the type I interferon and NFKB signaling pathway by TRIM9s 115004 57506 29110 3661 PMC4858538__F4 Role of p38 MAPK in Wnt signaling 4041 4040 1855 2932 1499 6925 PMC4861305__F1 Decorin induces autophagy in endothelial cells 1634 2475 5178 PMC4861419__F6 Schematic illustration represents the potential signaling transduction mechanism by which cancer cell-derived exosomes prevent monocyte apoptosis 843 841 836 PMC4862604__F2 Repair Pathway Choices and Consequences at the Double-Strand Break 55183 472 672 PMC4862632__F1 Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro 1950 8717 7099 4615 7186 841 5970 108348016 836 6774 1956 1401 4318 PMC4863537__F1 Pharmacology and rationale for imatinib in the treatment of scleroderma 6714 4087 4088 4089 PMC4866972__F1 Intrinsic and extrinsic pathways of apoptosis 8772 8717 7186 637 56616 581 PMC4866972__F3 Principal cell death pathways involved in intervertebral disc (IVD) degeneration 637 8772 664 7249 7248 6009 56616 2475 PMC4867322__F1 The Hippo signal transduction network and its links to exercise-associated signals and signalling modules 5728 207 7248 9531 4485 4133 60485 6788 9113 9686 7003 8463 7004 7005 27349 PMC4869873__F4 Schematics of the inside-out signaling of integrin activation 2268 3718 3717 6850 7409 695 387 5880 5331 5330 5337 23396 2931 4485 PMC4871587__F3 Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis 2248 6240 100188776 79023 2885 5336 3955 51118 3037 1891 56940 64343 4609 PMC4872787__F6 IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer 9235 6774 6935 648 6657 999 79923 PMC4879891__F1 Canonical Wnt signaling pathway 4041 4040 1499 324 7008 PMC4882019__F3 Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification 9332 22918 5473 6772 3827 330 80830 836 51316 6648 54504 2353 PMC4884942__F1 Targeting Notch to overcome radiation resistance 3714 182 102 4855 4853 4851 4854 5045 1950 3067 PMC4886063__F7 P2-dependent activation of the IRK/PI3K/Akt pathway 3479 5163 207 2932 PMC4887533__F1 Overview of the ferroptosis pathway 2937 27165 140805 6510 7037 PMC4889278__F6 Upon tumor progression E-cadherin downregulation leads to an increase of the proportion of CSCs and acquisition of the ability to form secondary foci of tumor growth 6657 1499 999 PMC4890337__F10 MWCNTg promote the EMT through the TGF-Beta-mediated Akt/GSK-3B/SNAIL-1 pathway 7039 999 1499 PMC4890621__F2 BIOPROSTHETIC HEART VALVES OF THE FUTURE 1401 94005 3384 3383 947 960 PMC4890990__F1 Molecular mechanisms of long noncoding RNAs on gastric cancer 6667 257000 6780 10365 378938 596 1021 2475 1869 1786 102723099 55384 10642 1871 283120 6935 100033819 285194 83698 861 PMC4891133__F7 Sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met 6469 6608 51684 2735 PMC4898408__F3 Hub-pathway network of GSZD 3725 7124 4049 2312 5624 1147 5468 2212 2908 142 PMC4898593__F5 Signal transduction from G-protein-coupled receptors and integrins 399 6714 6850 5336 1794 387 998 PMC4900151__F1 The role of REDD1 in the regulating muscle protein balance in response to acute alcohol 7249 6009 7248 8408 6194 PMC4900586__F5 Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations 2305 5329 4651 4430 3624 5328 5754 10630 4318 4312 4314 1288 4319 4322 9447 3371 3655 7045 6696 3918 6591 1001 9636 5744 2537 9805 3430 PMC4901515__F1 Cilia-mediated signaling pathways whose proper regulation is dependent on the proteasome and the structure of the proteasome 6469 5156 51684 6608 4087 4089 324 PMC4904147__F1 Antigen processing through MHC I molecules 6890 6891 567 7247 PMC4905223__F1 OGT links cancer cell metabolism and cell survival via regulation of HIF-1A 8473 10724 3939 5209 PMC4905361__F2 TNFR1 signaling 7124 1540 8717 10487 10486 81858 257397 8737 PMC4905575__F4 PP2A negatively regulates the mTOR signaling pathway 3667 5879 5163 64223 2475 253260 7248 7249 324 51256 2932 6009 8408 2887 PMC4905711__F1 Role of Nrf2 and Autophagy in Acute Lung Injury 9817 2730 8452 9978 4094 PMC4909545__F1 Nutrient-sensing mTORC1: integration of metabolic and autophagic signals 7249 7248 6009 64798 23604 9675 55626 7942 60673 9776 PMC4911360__F14 Gene-network of not isolated genes selected by Net-Cox in the GSE7390 breast dataset 1233 2263 4436 596 3578 2005 PMC4911365__F3 Tumor-supportive effects of BMAT 3569 6774 3479 3600 PMC4914279__F8 Epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells 1956 998 5879 387 9475 6093 PMC4915362__F3 Converging roles of caspases in inflammasome activation, cell death and innate immunity 355 4615 6850 64127 64170 114548 10892 8915 11035 8772 8737 3553 7124 PMC4916901__F1 Link between DNA damage and transcription, and pathway of DSB-induced transcriptional repression 472 9025 165918 9055 404715 PMC4917669__F4 Graphical abstract 7099 4615 3663 3661 3665 PMC4918128__F7 Networks of candidate cancer genes predicted by MUFFINN and their direct neighbors on HumanNet 3191 8833 1642 9219 4763 23013 54881 2033 1108 4893 7157 3845 8726 23512 1019 5036 5728 1457 8736 8454 54880 10594 29929 5097 10128 5062 26276 84056 5753 7428 23213 5903 165 5156 1436 5328 2335 5609 120892 1462 7204 775 7273 5494 8997 2047 1740 2199 4313 773 9863 2200 2192 53904 6098 4288 2324 7057 7450 65125 7075 1499 PMC4921457__F1 Mechanisms responsible for aldosterone synthesis in zona glomerulosa cells under normal physiological conditions and excess production in primary aldosteronism 3762 4666 4158 492 1499 1585 79798 PMC4923650__F1 Integration of RDGN with TGFB to regulate EMT 1602 6495 2139 7046 4090 4086 4087 4088 6935 9839 8091 999 PMC4924722__F1 The essential role of methylthioadenosine phosphorylase in prostate cancer 6303 4953 4507 262 4144 7298 7083 PMC4926123__F7 Anti-tumor effect of Beta-glucan from Lentinus edodes and the underlying mechanism 842 6774 581 142 PMC4926181__F2 HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ 9025 23118 10454 PMC4926301__F8 Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts 7099 4615 29110 3606 3565 PMC4928587__F5 Proposed model for the role of PALB2 in linking BRCA1 with BRCA2 and RAD51 in a pathway of HR 672 79728 675 5888 PMC4930117__F1 DNA end resection dictates the pathway choice for both DNA repair and checkpoint response DSBs can be repaired by NHEJ or by HR that requires 3′ ssDNA generated by end resection 472 545 84126 5888 PMC4933276__F10 The proposed T835M-UNC5C- and V642I-APP-induced neuronal death-signaling pathways 8633 351 998 5879 1612 3717 6774 9467 1271 PMC4935551__F2 Role of chaperone-mediated autophagy in metabolism 2203 5315 2820 84649 216 635 1431 4190 10226 3417 123 341 2271 3419 139322 PMC4935775__F1 Na+-Cl− cotransporter (NCC) regulation by the cullin-3 (CUL3)/kelch-like 3 (KLHL3)-with no lysine (WNK)-STE20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress response kinase (OSR1) pathway 130497 26249 8452 PMC4939383__F1 NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation 55054 7494 7186 64127 10392 PMC4940627__F6 Schematic diagram of the mechanism of THs regulating gallstone formation in vivoFXR/RXR heterodimers which mediate phosphatidylcholine and bile salt transporters (ABC-B4 and ABC-B11) are down-regulated by THs 3949 5244 8647 64240 64241 5091 PMC4942281__F2 Oncogenic survival signaling components in PCNSL 3565 6387 3586 10563 7099 613 4615 695 596 3716 3717 3654 6774 6778 5292 4609 PMC4946416__F1 PI3K/PKB/mTOR signaling pathway regulates cancer cell metabolism 7249 7248 6009 2475 4193 2194 1499 6925 4609 PMC4951304__F1 Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint 1017 8317 27122 4609 595 1021 1019 PMC4951461__F2 Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls 3620 7166 1384 PMC4955670__F6 Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer 891 4085 5347 890 4175 990 389 6790 9475 3484 595 5595 9133 7039 7157 6778 1030 1019 4790 5781 7033 1021 1958 1499 7103 4088 7050 7048 4193 PMC4956564__F2 NFKB-mediated regulation of inflammatory and immunosuppressive CD4+ T-cell lineages 4615 8717 7186 7187 64170 84433 8915 10454 23118 7189 5971 4791 2672 3558 3458 3569 6774 6775 10538 50943 6097 30009 3574 8320 3586 PMC4957033__F5 Top network of THC-regulated miRNAs 11218 627 406932 8742 8835 406992 834 406934 4773 6741 1019 9314 898 3662 672 4087 4088 693122 1029 PMC4959106__F1 De novo SL biosynthesis and S1P metabolism 55937 8877 56848 1901 124976 1674 PMC4961994__F2 Summary of TGFB signaling during EMT 6935 7291 117581 9839 3726 2354 8091 378938 7046 PMC4964175__F1 Pharmacological targets of ibuprofen 387 4099 718 56963 PMC4964437__F2 Lipid mediators and HIF1A signaling in hypoxic prostate cancer (PCa) cells 8877 4513 6714 2932 PMC4964491__F3 Flii involvement in inflammation 2314 7099 4615 9209 7189 PMC4967146__F1 Regulation of mRNA translation initiation by the mechanistic target of rapamycin complex 1(mTORC1) signaling pathway 3479 7249 7248 6009 1998 1977 6194 PMC4967210__F13 Schematic summary of novel TXNIP-NFYA-SREBP2/miR-33a-AMPKA/CROT/CPT1/HADHB signaling pathway conferring TXNIP regulation of myocardial fatty acid oxidation 10628 4800 54677 3032 PMC4971811__F7 Proposed model for increased IL-6 and leptin production caused by global Zip14 deletion 3569 7099 3717 6774 7189 4615 114609 PMC4972113__F1 Mechanisms of tumor responsiveness to statins 9961 382 57669 3156 PMC4972972__F1 Dual regulation of GSK3 by the PI3K/Akt/GSK3 pathway and PLIN2 4040 4041 123 1499 595 3667 324 PMC4973073__F4 Downregulation of PPAR pathway and bile acid biosynthesis and secretion pathway 2167 5465 5468 5467 948 1376 8309 336 51703 2180 1962 345 2182 1593 5360 9415 1581 949 7108 8714 6646 2052 343 10858 9420 80270 8647 10998 PMC4975621__F5 CAR targeted miRNA and mRNA in liver cancer 4363 5465 2244 2194 8714 3479 8720 6675 2063 1548 6774 116519 3988 79602 1244 3638 710 8473 PMC4977063__F7 Model deciphering the signalling pathway hijacked by EspT leading to induction of inflammatory responses in macrophages 3553 998 5879 3603 PMC4979424__F8 Proposed model of VacA effects on Cx43 and autophagy, followed by apoptosis 4035 5879 8411 55054 3916 PMC4979452__F5 JAK-STAT (Janus kinase/signal transducers and activators of transcription) pathway 7039 1950 3458 1956 2064 1234 5008 9111 2178 6778 6774 6772 186 1431 3558 6722 3595 PMC4979518__F6a mTORC2 controls cancer cell survival by modulating gluconeogenesis 2168 6774 3276 6256 2475 5106 5105 253260 7248 7249 84335 5594 1017 1147 6446 6009 2821 2203 8789 226 229 2597 5230 5232 5223 5224 2023 2026 2027 PMC4980330__F1 The core of the Hippo signaling pathway 4485 60485 9113 PMC4981742__F1 Mitochondrial dysfunction in gliomas- Evasion of Apoptosis: Impaired mitochondrial function due to the genomic mutations in mtDNA leads to impaired function of electron transport chain thus enhancing generation of ROS 1950 2475 4193 581 317 PMC4982433__F3 Signalling pathway and targeted therapy in gastric cancer 3082 2263 6608 5727 5163 5894 2475 58508 2146 4297 PMC4982440__F6 Proposed Model of PI3KA Resistance in SGK1-Expressing CellsPIK3CA-mutant breast tumors depend on the PI3K pathway, which mainly signals through AKT 6446 5163 7249 6009 PMC4984448__F2 Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children 9927 4976 10533 9474 65018 PMC4985055__F1 TGFB signaling in bone 7939 10454 4087 4088 4092 4089 64750 PMC4985183__F6 Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer 5934 472 1616 5925 7018 5591 7027 9612 4176 1499 51592 9611 2146 5371 6117 4609 1017 5926 22938 10155 1387 142 7157 983 6188 10036 10612 8021 324 1108 PMC4991447__F9 Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1A via the PI3K/AKT/mTOR pathway 2475 999 1000 PMC4995061__F1 Plasticity of Arterial and Venous Endothelial Cell Identity – Some Nerve! 8829 1948 2050 PMC4999430__F1 Interplay between EPEC/EHEC and inflammasome 58484 8772 114548 PMC4999628__F5 A model for a role for AIISp in the repair of DNA ICLs 55215 2177 2189 2067 PMC5002062__F1 ClC-Kb/2 expression and function in the distal nephron 83959 65125 65266 PMC5002468__F1 Calcineurin/NFAT signaling pathway 6262 6261 6263 3480 4803 627 PMC5002480__F1 Cross talk between multiple signaling pathways involved in tumor progression and resistance 6010 675 7018 545 472 PMC5008685__F2 Mechanisms of initiation of translation 83939 468 2001 1983 1997 10209 1999 PMC5015042__F1 The mTORC1 amino acid–sensing pathway 652968 375 6009 153129 PMC5016207__F2 Factors involved in the ontogeny of fetal Leydig cells 7490 50846 268 3815 269 3082 3479 170302 7049 7536 2626 3164 1394 6476 PMC5019081__F3 Wnt signaling pathways regulate gene expression and cell movements 4040 4041 4920 387 998 5879 324 PMC5023675__F1 TNF-Alpha-activated canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) signaling pathway 8717 7186 23118 PMC5029616__F1 Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters 387 2932 4318 4313 PMC5031078__F1 RAF/MEK dependence of KRAS mutant pancreatic ductal adenocarcinomas 3667 4763 5163 3845 5900 5728 7157 PMC5031543__F3 HGF signaling pathways; A) Representative structures, cMET binding affinities (KD) and dimerization of HGF, NK1 (cMET agonists) and NK2 (cMET antagonists 3082 5894 2549 PMC5033243__F2 Emerging role of mTOR in the response to cancer therapeutics 4763 5728 7249 7248 51256 324 6009 3643 3815 2064 2065 1956 558 PMC5034715__F4 Metabolomics analysis of hormone-responsive and triple-negative breast cancer cell responses to paclitaxel identify key metabolic differences 1545 1576 4134 4137 4133 1244 9429 PMC5035901__F4 KEGG pathway analysis of the validated miRNAs 1499 5925 1869 7039 51176 595 2932 9586 5728 4193 7157 5154 3480 5266 4790 596 2885 1026 6654 842 5594 PMC5036051__F3 Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer 2305 4605 1876 2146 2188 641 55215 2175 146956 5427 84108 83463 7161 10153 1869 7018 PMC5037279__F6 Proposed model for how mTORC1 activity controls pro-IL-1B expression 7099 4615 7189 7248 3553 PMC5039587__F1 Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells 7099 54472 929 4118 51135 4615 3656 59307 7189 257397 3725 23118 2353 PMC5039587__F2 Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells by acidic (APS) and neutral (NPS) exopolysaccharides produced by Lactobacillus plantarum N14 and Lactobacillus delbrueckii TUA4408L 594857 7097 7099 59307 54472 929 3656 51135 7189 4118 257397 23118 3725 2353 PMC5040984__F1 Patents and clinical trials involving the Wnt signaling pathway 8549 324 8658 1499 PMC5041197__F7 CD95-mediated cell migration occurs through a Bcl-2/BclxL/VDAC1/MCU-driven mitochondrial calcium loading 1956 84876 8772 6786 572 637 581 27429 90550 PMC5048206__F2 Schematic depicting the major proinflammatory glial-mediated changes to inhibitory synapses within the spinal dorsal horn that facilitate central sensitization 3553 6347 7124 3458 PMC5051518__F1 Simplified diagram of the adaptive and apoptotic pathways of ERS 468 83939 581 22926 7494 PMC5052620__F10 Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGFB pathway in precancerous Oral Submucous Fibrosis 4087 4088 655 1386 3725 7057 PMC5054603__F3 Gene expression changes in neurotransmitter signaling pathways 94235 2791 2771 2775 2568 2557 55970 2773 2784 2786 5567 2561 107 2565 196883 112 55879 2787 9568 2564 113 9001 10681 2793 2559 776 4905 3763 66008 2556 5566 11337 773 51764 2562 5334 2782 2783 10243 54331 2567 2554 2790 59345 2785 2555 2566 2788 2792 2563 815 816 8973 2534 2770 3717 2767 2776 8503 10000 23533 5594 5595 596 2353 5330 1386 1814 1815 2774 5516 2890 2891 5529 5500 3798 5518 5603 5599 5601 5602 3800 2932 2931 PMC5055575__F9 The signalling pathways mediating PTH and BMP-2 induced regulation of Phospho1, Smpd3 and Alpl in osteoblast cells 650 5741 5745 55512 162466 249 248 657 PMC5056494__F1 Signal transduction pathway mediated through CLEC-2 27040 695 6714 6850 PMC5059336__F3 miRNAs modulation in direct cardiac reprogramming 2626 9464 6910 PMC5061804__F1 Cellular signalling upstream and downstream of mammalian target of rapamycin (mTOR) complexes 2475 3480 5728 2932 64798 2308 2309 2152 7249 7248 6009 6194 1975 8408 60673 9776 PMC5063343__F5 Heat Stress and Lipopolysaccharide Stimulation of Chicken Macrophage-Like Cell Line Activates Expression of Distinct Sets of Genes 7099 3593 9821 9516 51182 3606 7189 3458 55466 958 3306 3298 6351 842 3725 10049 836 10808 PMC5064167__F1 Upstream and downstream mechanisms of the ERK5 signaling cascade in DRG neuronsDashed lines indicate the need for further examination of possible signaling or the mechanism, which is complicated and abbreviated in this text 4803 6714 627 4205 4208 PMC5067255__F7 Proposed model for the profibrotic regulation of GLUT1 expression by TGFB 4087 4088 5062 PMC5067484__F1 Reelin signaling pathway in the developing cortex 1000 7436 1600 1398 1399 2932 2475 PMC5068743__F5 Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis 92140 28988 2017 261729 200081 10016 468 2922 9793 115817 10961 3336 8754 5694 78990 7336 51366 2346 983 80124 PMC5069610__F2 NMI influences cancer initiation 9111 472 4609 2932 4193 55332 PMC506992__F7 MUC20 suppression 200958 3082 2549 2885 PMC5070717__F2 GSK3B in TLR3 signaling 7098 2932 7189 10454 23118 3661 29110 7187 PMC5074868__F8 MYELOID HSF1-Beta-CATENIN AXIS REGULATES NLRP3 INFLAMMASOME ACTIVATION IN MOUSE LIVER ISCHEMIA/REPERFUSION INJURY 7099 4615 7189 3297 114548 1499 3553 PMC5076476__F2 Pathogenic viruses target RLR regulation for immune evasion 5763 7706 57506 1283 9474 29110 PMC5076853__F1 More to life than NFKB in TNFR1 signaling 7124 7186 8737 8717 23118 257397 81858 PMC5078608__F7 Ca2+Signaling Pathway Proteins that Are Regulated by Homeostatic ScalingIntracellular signaling pathways 9254 6786 5530 5566 490 55799 57620 5567 5532 816 785 10105 3241 2778 1128 51440 488 115 8428 4638 1910 2767 5747 1956 2066 4790 5332 5579 5595 2353 5581 613 51741 5599 25791 7074 94134 57584 5921 23092 22843 8491 23162 9743 9448 57460 PMC5080657__F2 Genetics of immune-mediated disorders 10019 6281 1316 117289 83888 3678 2353 387882 2999 6352 23645 3423 91662 91663 1396 9112 7378 8767 9246 9050 6772 2633 83666 6890 2634 115361 PMC5082287__F3 Pathway depicting Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes identified in the present analysis, which could directly or indirectly affect skeletal muscle cell functions 6288 2149 80829 29114 6840 4617 7042 4205 4208 26548 9200 3908 1756 3911 3992 PMC5082287__F5 Relevance network over-viewing discussed relationships between Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes and cell processes (Pathway Studio Web Mammalian) 2101 4843 51099 7042 1756 PMC5082879__F2 Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models 7739 1063 8497 399687 1382 3047 5251 55193 1545 23532 4237 9244 4605 6662 2273 64151 6772 1846 7038 1062 828 6542 2258 4065 3783 10253 25984 2030 7802 10252 6653 7025 81848 6228 54769 4739 PMC5082879__F3 Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models 26747 5378 3690 900 672 4869 4609 1796 4292 7157 80144 27030 2064 6774 1111 1356 6382 8945 5984 7534 996 7049 6383 8454 4605 857 712 10575 1869 9507 7186 1791 5111 PMC5085112__F7 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease 355 3156 64240 5244 3949 8647 PMC5085669__F1 MTOR signaling network in mammalian cells 3479 64798 7248 7249 6009 8408 1977 3667 PMC5086093__F7 Models depicting consequences of PNH-related mutations on NEDD4L stability and PI3K/Akt/mTOR and TGFB/Smad pathways 23327 717 1600 5163 4087 4088 7249 7248 6009 PMC5089941__F1 Mechanism of appetite regulation by the hypothalamus and peripheral tissues 1392 7200 4160 5443 4852 181 5697 885 PMC5093979__F3 Genes and interaction relationship in the module 31 (a) and 35 (b) 27122 22944 9447 2170 3659 5111 9156 2634 3980 2633 5425 10714 3660 PMC5094708__F6 Mesenchymal Stem/Stromal Cells under Stress Increase Osteosarcoma Migration and Apoptosis Resistance via Extracellular Vesicle Mediated Communication 2194 6566 4312 5747 PMC5095034__F7 Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification 100653366 7852 3479 6774 PMC5101203__F1 Putative pathological production of AB and NFKB signaling in neurons 23621 1958 627 4852 1959 PMC5101236__F1 Schematic signaling pathways elicited by VEGF 3791 8829 6654 2475 3725 2353 4609 PMC5104320__F4 MinePath: Mining for Phenotype Differential Sub-paths in Molecular Pathways 685 1956 2885 1839 2475 2549 1978 3084 10000 23533 2065 9542 1027 PMC5104508__F1 Classical view of progressive linear cascades in the asymmetry-determining pathway 6469 4086 4089 4838 2253 4087 5308 PMC5107592__F1 Toll-like receptor signalling pathway 27250 7097 7099 7098 54106 7189 29110 3661 3665 114609 929 4615 51135 3654 PMC5108321__F9 The working model of AMDE-1-induced canonical and noncanonical LC3 lipidation 25801 8408 26100 10533 9140 9474 83734 PMC5113305__F1 Molecular mechanisms supporting the proliferation of HCC cells despite serum withdrawal 207 6667 622 3155 5019 3157 3158 PMC5117516__F1 Viral sensing pathways that trigger host immune responses 3569 7297 3716 4615 64127 6773 3654 7189 7187 23118 57506 10379 114548 29110 3665 3661 3606 6772 PMC5120123__F2 Positive regulatory signaling for Tfh differentiation 29110 6774 2308 83737 10365 604 643 29851 3458 430 7409 PMC5123561__F3 Heterotrimeric G Proteins: Breaking the rules of engagement, space and time 7099 3643 1956 6714 1020 4087 6774 5335 4313 596 4318 2308 2475 PMC5126841__F9 Schematic representation of the study 3553 3458 4513 PMC5131788__F2 Molecular mechanisms underlying alcohol-drinking behaviours 627 2668 5979 4763 5187 8864 3265 9575 4852 1814 5173 PMC5134922__F4 Ingenuity Pathway Analysis of the top overlapping networks in chronic beryllium disease and sarcoidosis 1154 3559 3659 3726 598 8554 7124 5732 9021 4092 8835 PMC5136547__F4 Beneficial effects of immunobiotic bifidobacteria on the innate immune response against rotavirus in intestinal epithelial cells (IECs) 7297 3716 6772 6773 7098 7187 7189 57506 3661 3725 2353 6041 6035 3627 PMC5137279__F4 Pictorial representation of altered GABA receptor signaling due to PCP-SI treatment 18 223 140679 4329 1356 10243 11337 1759 29979 4905 PMC5137819__F1 Phosphatidylinositol‐3 kinase (PI3K)–AKT PI3K‐AKT pathway is activated upstream by ligand binding to a growth factor receptor, in this case a receptor tyrosine kinase (RTK) 5728 5163 5164 572 2475 4193 2308 4303 PMC5138252__F4 Examples of genes (in red) within the HIF pathway in which positive selection has been identified in high-altitude populations 112398 54583 112399 4842 4843 2034 3091 405 9915 2056 5465 3163 PMC5138592__F5 Identification of critical paralog groups with indispensable roles in the regulation of signaling flow 4087 85451 2932 4851 4855 4088 54567 10683 182 3714 4192 1840 3955 4242 83737 23220 6868 102 51176 PMC5146691__F5 Biosynthetic pathway: nucleic acid detection from within the cytosol 23321 9447 115004 7186 7189 7188 29110 57506 3428 PMC514817__F4 Interaction of stress and inflammatory responses 3297 3725 2002 2353 3569 PMC5149556__F1 Molecular events that connect inflammation to insulin resistance in obesity 7124 7186 8717 7097 7099 4615 7187 5163 29110 3661 3603 PMC5155150__F6 Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells 10637 652 9350 6422 22943 PMC5157014__F3 Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice 345930 56171 135892 388561 55824 9002 118471 54859 9337 389549 9118 200008 150696 7273 1463 10262 PMC5159651__F7 Suggested model for modulation of Wnt pathway by OCC-1 splice variants 324 55198 10297 1499 PMC5165248__F1 Simplified schematic depiction of a hypothetic PrPc-induced signaling cross-talk between PI3K/Akt and Wnt/Beta-catenin pathway under hypoxic conditions 2932 1499 1958 5621 5163 3939 PMC5179106__F3 A) Protein-protein interaction analysis of 524 AD-related proteins revealed two large protein clusters: the APP network (14 yellow nodes) and the CAD network (11 red nodes) 790 2571 2572 9945 2673 PMC5184782__F1 Context-dependent TGFB signaling pathway 1601 2885 3690 6714 79834 6935 4087 4088 4089 2736 4092 6495 10413 PMC5187886__F2 Possible mechanisms of estrogen or EED action 5728 6651 1832 4899 6667 2353 3725 PMC5187887__F1 Schematic diagram representing chromosomal DNA and the major components of the DDR signaling pathway (top) 3014 693122 472 545 993 596 672 1017 100126303 675 693215 407047 27250 5893 PMC5190062__F8 ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis 5888 4255 468 PMC5190133__F1 Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment 2146 860 51147 2308 581 637 1499 5728 8091 3479 8772 PMC5192062__F2 IL-17 and IL-17 receptor family 64806 55540 84818 132014 7189 10682 PMC5193490__F2 Nrf2 affects mitochondrial function at multiple levels 4199 2539 3417 355 PMC5197954__F1 Intronic microRNAs (miRNAs) and the miRNA-488/ZIP8/MTF1 pathway are critically involved in the pathogenesis of osteoarthritis (OA) 4520 4322 4087 PMC5198184__F1 Metabolic stress-mediated induction of an inflammatory response via ER stress signaling pathways 22926 2932 7494 83939 6347 834 3553 PMC5203884__F1 p53 suppresses the cell proliferation mediated by the Rb-E2F pathway 1021 1019 1017 4193 545 472 PMC5206730__F6 Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial 3082 4803 1950 929 998 5879 6714 5058 10006 83871 382 PMC5216469__F3 Regulatory feedback mechanisms govern Etv2 expression 1827 1385 2116 2624 PMC5216784__F10 Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1A and PERK pathways 22926 468 7494 PMC5219787__F6 Ezrin pathway 3383 960 6010 PMC5226613__F1 Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases 2263 7249 150365 2475 9140 664 5879 2252 PMC5233484__F1 The canonical and non-canonical autophagy pathways 7939 9474 10533 8408 PMC5233495__F1 Canonical and non-canonical hippo pathway in ischemic heart disease 4485 60485 9113 4771 PMC5240660__F9 Evolutionary history of the PTH family in vertebrates 113091 5744 162466 1431 5251 8074 957 PMC5240838__F8 Proteostasis network via the HSF1-SQSTM1 axis 3297 29110 8878 PMC5242448__F1 Cell signaling transduction pathways controlled by WISP-1 in different cancer cells 4851 6714 1956 4313 4318 3383 7422 PMC5242532__F1 Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1 79633 960 23418 56288 9414 154796 166824 60485 84962 9113 26524 7159 PMC5253631__F8 Exome and genome sequencing of nasopharynx cancer identifies NFKB pathway activating mutations 3105 3106 7189 5290 4763 4893 3845 7187 5728 84166 2475 1540 1029 595 4792 2033 2956 9641 116931 55294 7157 4292 PMC5259907__F4 Network constructed based on 1956 472 2308 4609 8772 841 637 581 842 836 PMC5260500__F3 DAB2IP in TNFA signaling: activation of ASK1/JNK 7124 8717 7186 153090 3550 PMC5260505__F6 Proposed function of CDK1 in regulating pluripotency 983 4087 5163 2932 PMC5274667__F6 Cross talk between lipid/glucidic metabolism and cancer 4023 27329 51129 3479 PMC5278183__F2 Regulatory Roles of the Cytoskeleton at the Base of the Cilia 10013 6790 3983 22885 387 6714 3985 7016 5347 585 PMC5278183__F3 Relationships Between Cellular Proteostasis and Ciliogenesis 6790 54820 7248 7249 6103 6009 2932 585 8481 9474 22863 90410 8100 10013 PMC5279903__F1 Molecular mechanisms of JNK1 and JNK2 in obesity-driven insulin resistance 1386 2002 3725 3667 8660 3569 9611 1734 26291 7252 PMC5282877__F2 Signaling involved in CSCs that mediates melanoma progression 3488 6608 4851 3480 4893 673 387 2735 2736 8650 4609 4435 1869 3091 PMC5283822__F2 Ubiquitin signaling during lesion recognition in the GG-NER pathway 23358 54726 7874 158880 8450 1643 9978 7508 1642 8451 54778 7353 PMC5285348__F3 Canonical Wnt signaling pathway 324 1499 51176 PMC5285348__F5 Mycobacterium tuberculosis (M 7124 8321 7099 7475 4615 7473 1499 PMC5285348__F7 Nucleotide-binding oligomerization domain 2 (NOD2) and the activation of the Wnt pathway in response to Mycobacterium tuberculosis infection 130574 64127 324 1499 331 3603 51176 PMC5285348__F8 Mutual regulation between miRNAs and the Wnt pathway determine the survival of Mycobacterium tuberculosis (M 7097 115201 4615 26959 324 639 22943 2309 7124 8322 PMC5286373__F3 Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype 5723 26227 29968 25902 6472 10797 PMC5287080__F3 Transforming growth factor B (TGFB)-induced activation of the PI3K-Akt pathway 4088 4089 7291 PMC5288170__F1 Molecular mechanisms of OLIG2 transcription factor in brain cancer 6469 6608 5727 4193 2247 116448 10215 2263 8643 6929 1021 1019 3092 387 PMC5288713__F6 Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage 3603 834 58484 4843 PMC5290251__F1 Nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) pro‐inflammatory signalling pathway 114548 10392 5688 64127 7128 5987 55914 331 23118 257397 790 22900 PMC5290952__F10 Proposed mechanism whereby RET/PTC3 regulates IDO1 expression in thyroid cancer cells 5979 6714 3659 3620 6772 PMC5292006__F4 Ingenuity pathway analysis of uniquely hypomethylated promoters 7124 3581 3716 3718 9021 8835 602 941 942 940 27040 2885 3932 3717 2534 1493 3558 PMC5293538__F1 Abbreviated polyamine synthesis pathway 6611 6723 79814 6303 PMC5295433__F8 G-protein-coupled receptors mediate omega-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway 4485 9113 374 4671 4170 7018 329 PMC5297719__F1 Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat? 3480 6714 5728 2932 2931 PMC5301133__F2 Mechanistic basis of secretory regulation in a neuroendocrine cell 1812 885 117 135 1813 PMC5301133__F4 Protein interactome involved in neuroendocrine neoplasm proliferation.Proliferative signaling includes a tightly regulated signaling interactome (including RAS/RAF, MAPK, and PI3K/Akt) 64400 10916 253260 10000 546 7248 4194 6237 1616 11186 5900 7249 2475 22800 5290 673 4193 1029 3845 7048 5728 7046 3265 4092 4763 5605 5594 4613 5604 7434 1956 2353 9112 4296 3727 3726 PMC5306369__F1 Complement activation and evasion by NS1 protein of flavivirus 735 716 721 720 718 730 729 55329 PMC5308739__F3 Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network 2056 10000 572 3845 2444 5898 7039 1950 3716 7157 PMC5308909__F7 Schematic diagram illustrating the possible interplay between the EGFR and CK2 signaling pathways that regulate GBM cell proliferation 1956 11140 5728 1499 2735 PMC5311241__F9 A positive feedback loop from Snail to Cat L to CUX1 and back to Snail drives EMT and can be inhibited by Cat L inhibitor 847 1523 999 PMC5313050__F3 Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol 1376 122970 355 1559 5226 PMC5314358__F8 Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGFB1 7189 4087 4092 4091 10365 9314 6401 3576 3383 6347 7412 6876 PMC5314913__F2 Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases 940 920 3932 5867 7040 3458 7124 2271 PMC5315281__F5 De novo assembly of the sea trout (Salmo trutta m. trutta) skin transcriptome to identify putative genes involved in the immune response and epidermal mucus secretion 192134 29071 9334 PMC5316308__F2 DREAM as a novel therapeutic target for anti-thrombotic agents 7006 100124696 695 27040 2534 4067 5336 6850 6714 PMC5316486__F3 Transposon mutagenesis identifies candidate genes that cooperate with loss of Transforming Growth Factor-beta signaling in mouse intestinal neoplasms 92 91 659 657 1739 960 1453 9113 7529 7531 4092 4087 4088 10971 7534 4089 5170 8454 10413 6497 2033 1387 999 3655 4041 4040 3688 2885 5287 5295 8313 22800 5879 4739 5728 2932 324 5894 5518 80895 5062 1452 6929 6932 PMC5319818__F1 Gasotransmitters in cancer: from pathophysiology to experimental therapy 4513 3091 2247 7076 PMC5322275__F3 Schematic model summarizing the findings of the proteomic and metabonomic profiling analyses 2892 2890 2891 1742 1740 816 6010 54487 2475 818 406961 6844 2932 8927 6899 7290 1312 10587 PMC5322732__F6 Summary and pathway schematic 1956 2064 999 2782 54206 5290 4763 5921 5295 4216 4893 3265 3845 200734 5728 5606 4135 161742 207 673 4214 1432 7249 7248 6009 5604 6416 55749 2475 4771 57646 5594 5595 4616 8452 9817 124245 1654 23152 1027 5074 595 1026 1021 1019 4609 7048 92 4149 4089 2115 5925 472 84295 9439 55193 8289 57492 6598 196528 7403 8242 3169 6256 3725 PMC5323396__F1 TLR molecular cascade 4615 51701 2932 PMC5323854__F7 Putative mechanism of necroptosis in the development of intestinal injury following intestinal I/R 7099 197259 3146 PMC5324334__F7 TSPC induces cell cycle G1 arrest probably mediated by CDKN1A and CDKN1B CKIs in a TP53-independent manner, while CDDP induces S and G2/M arrest via TP53/CDKN1A pathway in SK-MEL-5, and preventing dephosphorylation of CDK1 in both cell lines 1017 1026 7157 9134 983 PMC5325762__F3 The DNA Damage Response During the Life Cycle of Human Papillomaviruses 472 10111 9656 165918 4361 672 PMC5325762__F4 The DNA Damage Response During the Life Cycle of Human Papillomaviruses 84126 545 11073 5884 PMC5329966__F3 Heterogeneous responses of normal and malignant B cells upon CpG ODNs stimulation 355 54106 6772 4615 51135 3654 7189 581 941 942 PMC5330146__F2 The SOLLI model predicts targets of therapy 6319 619501 5465 729230 PMC5333035__F5 Fibroblast growth factor-4 (FGF4) signal transduction pathway governs trophoblast proliferation and differentiation 51053 2249 324 207 983 PMC5336271__F4 Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology 5396 7088 4609 1601 2200 7422 3646 8320 5008 3487 6794 3084 6774 7157 8877 7124 7052 5594 3209 1499 650 6608 6615 1270 23476 85453 5728 94103 3665 9020 8651 2322 1326 2064 5054 284 93649 PMC5336494__F1 Diagram of Notch signaling 595 100188776 4318 PMC5337960__F7 Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells 6929 80310 5894 26281 8714 3516 5552 1439 9794 6876 1499 1855 928 4478 7852 8817 5294 3488 7474 5291 6868 6774 2534 8321 2524 6515 2932 83700 3398 5159 2113 8322 2549 5781 50848 4921 3091 1462 1958 6608 3587 5293 2885 3280 4851 4609 3934 324 7846 1956 7145 4893 6385 10818 5290 6615 8312 1832 2791 4087 4088 6591 5295 207 5296 6925 23336 3875 7048 607 3728 3082 4638 7431 5788 1000 1950 7494 4089 2162 10140 2273 4318 6678 30008 999 57154 7430 9839 3371 387 4015 145258 23220 4179 8091 6935 7046 10398 84617 2303 4313 PMC5338934__F1 Transport pathway of irinotecan.Notes: A prodrug, irinotecan, is moved into hepatic cells by passive effusion 324 1066 8824 5243 54658 1244 PMC5341142__F2 Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders 4035 5156 1958 6667 PMC5342330__F9 Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells 28514 84708 6714 8650 4851 6774 6657 79923 3480 PMC5342493__F5 Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma 8829 7040 4087 1003 PMC5342520__F2 Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies 2774 10105 55384 439931 487 859 23236 113026 100287569 8847 5501 6093 440823 81 7791 100505641 8525 341567 5747 894 5728 6464 80271 3706 284836 810 PMC5342665__F1 Steps in the LDLR metabolic pathway 255738 3949 4035 10802 PMC5343002__F2 Cellular NAD+ biosynthesis and consumption processes 93100 64802 349565 23057 10135 PMC5343002__F3 Adipose tissue pathways regulated by sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) based on current literature in mouse models, adipocyte cell lines and human studies 22933 23410 23409 51548 51547 10135 23411 142 PMC5343835__F3 Proposed interaction of AQP1 with Wnt/ Beta-catenin signalling and cadherin-catenin complex 4040 4041 999 1499 358 2932 324 595 PMC5343846__F1 Wnt/Beta-catenin pathway is potentially deregulated in PCas 22943 324 1499 8313 7490 79577 3090 4040 PMC5343846__F2 Effects of the loss of cell division cycle 73 (CDC73)/parafibromin on epigenetic regulatory mechanisms in PCas 1499 79577 9810 56254 2146 PMC5343902__F2 Mammalian target of rapamycin (mTOR) pathway 1950 1956 2885 5728 5163 7249 7248 6009 8408 PMC5344939__F1 Molecular mechanisms of PI3K-AKT-mTOR signaling cascade related neurodevelopmental diseases 5728 5163 2290 PMC5345933__F2a Cell cycle proteins as promising targets in cancer therapy 2308 2309 2152 472 4089 2931 4609 1499 729 1017 1019 1719 890 PMC5346293__F2 Signal pathway integration that regulates Hsp90 expression 6772 6774 11171 3297 PMC5348352__F5 miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival 619501 5728 7534 1000 4318 999 PMC5348361__F9 Components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model 581 2539 4094 PMC5348722__F1 Translating genomic profiling to gastrointestinal cancer treatment 999 1956 7422 5728 4089 2475 4087 4088 2146 595 898 4193 7157 PMC5348722__F2 Translating genomic profiling to gastrointestinal cancer treatment 3481 1956 4893 3845 324 5728 673 4089 1499 4087 4088 2475 4609 55294 545 472 7157 PMC5350105__F1 M1 macrophage metabolism 10157 355 47 23152 4199 3939 790 8011 PMC5350610__F3 The consequences of perturbation of CUL4CRBN E3 ligase function 51185 1642 4212 2935 PMC5351668__F5 Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets 2167 335 336 5360 6095 9415 10999 4023 1374 1376 30 33 6342 34 10580 3611 7316 PMC5354443__F11 Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway 983 995 545 PMC5354895__F14 Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGFB signaling 999 1000 6667 PMC5354927__F1 Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication 100124700 5978 407046 378938 6366 400500 2736 PMC5354927__F2 Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication 406991 60674 8841 7503 105416157 PMC5355173__F8 Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells 7157 8313 7473 7471 4040 1021 23411 999 1499 1000 PMC5355523__F7 Putative mechanism for the interaction between miRNA and the Ago2, Pum2, and REST proteins 3065 3066 27161 4343 2332 5978 23369 200424 175 PMC5357196__F3 Biosynthesis of the methylthioxylose capping motif of lipoarabinomannan in Mycobacterium tuberculosis 828 4693 4860 PMC5357279__F2 Intracellular trafficking path for SORLA 81609 26088 23062 55690 23163 PMC5357489__F3 Cross talk of the Wnt/Beta-catenin pathway with the epidermal growth factor receptor (EGFR) and fibroblast growth factor (FGF) pathways in hepatitis C virus (HCV)-related hepatocellular carcinoma 999 85409 2932 595 1956 4040 4041 PMC5357538__F2 Wnt, Hedgehog, and Notch canonical signaling pathways 6469 6608 3549 51684 324 7008 PMC5359577__F10 Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells 7226 8505 759 PMC5359747__F1 Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction 382 4615 1003 6714 54538 5879 387 PMC5360511__F5 PPARG targeted oral cancer treatment and additional utility of genomics analytic techniques 3916 1071 2815 858 948 2313 100133941 8567 3178 PMC5360546__F4 Hippo pathway 4485 60485 9113 PMC5362437__F5 Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3Beta-involved Wnt/Beta-catenin pathway 2932 1499 51176 6657 PMC5362546__F2 Long non-coding RNAs in nasopharyngeal carcinoma: As systemic review 100124700 60312 5880 8766 387 10890 5216 389 84740 9230 3927 1871 7503 2146 283120 693215 378938 6935 283131 999 PMC5363240__F5 Proposed role of RUNDC3B in the MAPK signalling pathway 1384 4342 154661 4149 4609 2002 4089 PMC5364265__F8 Putative transcription factor network for estrogen signaling 1869 1874 144455 1876 6657 2305 7022 PMC5366901__F4 Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients 367 2099 5241 3169 2932 PMC5367651__F4 Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells 100302167 100422883 100616143 100422905 367 5728 1027 693188 572 2308 5159 5154 10000 100422921 100423038 1387 2885 2932 595 100500913 6654 8517 3845 5894 100616487 4790 596 2475 PMC5368188__F5 LIN28A/ZCCHC11 regulation of let-7 microRNA biogenesis, promoting cellular proliferation and modifying bioenergetics 4609 3643 3098 10644 3099 890 8660 1431 1408 8091 891 1719 595 7083 896 894 204 64756 5471 993 79727 1021 389421 10606 113791 208 7248 253260 PMC5371185__F1 Schematic representation of the DNA damage response (DDR) pathway 472 545 7465 PMC5373538__F2 Proteomic characterization of epicardial-myocardial signaling reveals novel regulatory networks including a role for NFKB in epicardial EMT 5796 7837 5802 5368 5806 9255 7042 4267 10135 7045 671 PMC5376330__F9 Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway 2358 7408 5879 PMC5377416__F11 Regulatory network construction for the overlapped genes 3075 5743 4893 7189 3605 3184 2066 56957 26508 4089 4507 5187 10920 83660 7707 4853 253559 5791 PMC5380038__F6 PHS metabolic pathway 56848 8879 224 26061 PMC5380038__F5 Predicted PHS degradation pathway 130367 81537 56848 8879 224 253782 29956 204219 10715 79603 91012 7357 26061 PMC5380330__F4 MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells 356 8743 5008 7124 5551 3002 27040 3550 PMC5380548__F2 Wnt signaling and cellular metabolism in osteoblasts 4041 4040 2744 83939 468 PMC5382109__F2 Activation modes of NFKB in the pathogenesis of B cell lymphoma 930 6850 4067 5728 29760 10892 8915 84433 973 PMC5384838__F1 Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome 1103 43 4038 4593 8292 285489 6329 2673 1798 85365 199857 PMC5385611__F1 Cell migration induced by EGF via regulated alternative splicing of the Rho GTPase Rac1 1950 1956 80176 5879 PMC5388800__F1 Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging 920 355 947 940 5209 90427 970 1788 3458 PMC5388917__F5 Regulation of Akt signaling pathways after (A) vehicle, and (B) melatonin treatments following ischemic-stroke 5728 5163 2475 572 2931 2932 PMC5389977__F3 Release of growth hormone (GH), Wnt, or RANKL, as stimulated by progesterone (P4), promotes interaction with various signal transduction pathways 2690 3717 1499 6776 2475 51176 1956 1950 7018 5728 PMC5389977__F4 Interaction of HER-activated pathways with canonical Wnt signaling 1950 4582 3082 6714 1499 2932 324 5728 7018 PMC5390339__F1 Canonical Wnt signaling pathway 324 1499 4040 4041 PMC5391303__F1 Pharmacokinetic and pharmacodynamic evaluation of ibrutinib for the treatment of chronic lymphocytic leukemia: rationale for lower doses 7852 613 6850 4067 695 5336 PMC5392015__F4 GHRP mechanism of action 948 1636 59272 7040 3479 2475 PMC5393166__F1 Schematic overview of the Nrf2 pathway 9817 8452 9978 4094 PMC5393594__F4 Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells 11055 114327 51533 10734 26330 54558 6954 4956 3948 10881 6691 51087 PMC5393957__F2 Molecular genetics of osteosarcoma 2885 4763 5728 5163 7248 7249 2475 6009 2932 4771 7942 47 2194 1977 PMC5396079__F10 Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway 5163 7248 7249 6009 2308 9140 PMC5396097__F1 Autophagy-mediated regulation of macrophages and its applications for cancer 2475 9776 8408 5266 30849 7405 51100 8678 22863 55626 PMC5396384__F3 Inositol polyphosphates synthetic pathway 253430 80271 3706 3707 3705 9807 9677 PMC5397677__F1 Signaling pathways relevant to glial neoplasms in adults and children 2260 1956 5156 5728 5290 4763 3417 4602 4603 546 1029 7015 4255 673 7157 5894 3845 PMC5399913__F3 Anti-recombination and anti-crossover activities of Srs2 during replication and HR mediated DSB repair 5111 118027463 5888 5893 PMC540032__F1 CellDesigner () diagram of the insulin/IGF receptor signaling pathway 4803 3643 8471 3667 8660 5728 5163 5164 2475 PMC5403405__F7 Proposed mechanism for oridonin-induced G2/M arrest and apoptosis in prostate cancer cells 4193 581 983 PMC5403593__F3 Cartoon illustrating two independent parallel pathways in the post-mitosis G1 phase (G1-pm) in cell proliferation: MAPK and the Hippo pathways 4485 1956 9113 26524 10413 2002 PMC5404975__F1 Overview of the core components of canonical Hippo signaling 60485 4485 9113 26524 PMC5405080__F9 Functional p53 control of cell growth and oxidative metabolism 4193 2475 57103 2539 PMC5406529__F1 T cell immune checkpoints for anti‐tumor immunity 941 942 940 1493 7535 PMC5406854__F2 Ways of targeting MYC and its transcriptional output using specific signaling pathway, BET bromodomain, and complex inhibitors in MYC-dependent malignancies 2932 55294 4609 6790 4149 23476 7008 11201 PMC5411440__F1 Cellular and molecular pathogenesis of Helicobacter pylori infection in gastric carcinogenesis 1015 960 7099 2932 4089 4615 324 1499 4513 3091 56287 4149 596 6774 11186 PMC5412475__F1 Schematic presentation of the postsynaptic structure and function on the basis of acetylcholine receptor clustering centered on agrin- and Wnt-signalings, trans-synaptic communication and synaptic stabilization 1499 43 4593 55914 5879 6010 285489 1399 1398 8470 10580 3084 4038 PMC5412772__F1 TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different 8772 8717 5624 841 23118 197259 PMC5413580__F1 Generalized schematic of checkpoint molecule structure and expression, and the balance between stimulatory and inhibitory signaling 942 940 324 941 325 140885 961 4345 131450 3902 339390 634 3146 PMC5413598__F1 Hippo signaling pathway 4771 4485 60485 4478 9113 26524 9686 PMC5414755__F1 Signaling pathway regulating the initiation of autophagy and the formation of autophagosomes 9140 9776 60673 55626 55054 PMC5414836__F3 Cytokine Decoy and Scavenger Receptors as Key Regulators of Immunity and Inflammation 90865 3553 6761 3554 4615 6774 5728 2475 PMC5415203__F6 Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency 100187761 10111 4361 64170 115004 29110 3661 PMC5416822__F3 Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases 3454 3455 51284 7099 4615 6772 6773 57506 10379 9447 115004 2634 11035 8772 841 114548 115362 81030 PMC5416953__F5 Working model of the role of LXR in Fgf21 gene regulation in mouse liver during fasting 8841 27343 11201 26584 6095 PMC5417301__F11 Model summarizing the regulation of GR by TTC5 91875 4193 133746 PMC5418463__F1 Regulatory T (Treg) cells modulate CD8 T‐cell exhaustion, but the programmed cell death protein 1 (PD‐1) pathway determines viral control 920 940 7124 PMC5419167__F7 Genomic and nongenomic cross talk of the GnRHR and GR signaling pathways on the GnRHR promoter in LBT2 cells 23426 3725 2798 PMC5422478__F4 Autoantibodies in the pathogenesis of Graves’ orbitopathy 3479 3480 7253 958 7124 3667 2475 PMC5422712__F8 CD40-mediated apoptosis in carcinoma cells 958 7185 7187 581 PMC5424863__F2 Pathway hyperactivation defined by alterations of the PI3K/AKT/mTOR pathway 5728 5163 207 7248 7249 6009 PMC5426948__F2 Proposed signalling pathway showing that genetic loci deregulated through altered methylation in Beckwith-Wiedeman syndrome are upstream of pheochromocytoma-paraganglioma susceptibility genes 126669 4803 4763 5979 4221 2475 7428 4609 4117 PMC5432227__F6 Metabolic heterogeneity signature of primary treatment-naïve prostate cancer 29920 5831 5625 4942 8659 5832 2744 2752 3939 PMC5434854__F3 Association between the gene list and known processes pathways reveals a role for Glucocorticoids 7341 4088 2288 4792 10499 23426 PMC5435615__F5 Diagram of heme effect 9697 23471 4615 51135 3654 7189 51295 7186 23118 257397 10454 5606 9053 6416 10628 114548 3569 7124 941 325 114609 7099 7187 PMC5436279__F5 Several roles of scrapie responsive gene 1 (SCRG1) suggested in this study and our previous reports 9242 11341 683 7099 929 6367 PMC5436301__F6 Repression of or mutation in several upstream regulators of homologous recombination (HR) can be synthetically lethal with PARP1 inhibition because they can cause a variety of HR repair defects that prevent fork restart 142 5728 8237 3014 4361 5888 641 7486 5426 PMC5442293__F1 Role of WIP1 phosphatase in termination of DNA damage response 545 472 994 993 995 4193 1026 PMC5442653__F3 Potential usage of nanoparticles for splenic targeting 4218 5728 10000 207 208 2475 PMC5445662__F1 Intracellular signaling pathways associated with IR-induced cell death modalities 11035 355 472 5728 9706 7249 581 2475 836 842 PMC5449256__F1 Oncogenic growth factor signaling mediating tumor escape from cellular immunity 1950 1956 238 3717 6774 5728 6772 6347 6352 PMC5450331__F1 Signaling pathways of TLRs include MYD-88 independent and MYD-88 dependent pathways 7098 4615 51284 8772 51135 5879 3654 3656 7187 7189 3665 3661 7099 54106 7097 7100 10333 PMC5450629__F8 Tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas 3479 6778 3480 8205 3566 3565 PMC5450843__F10 A model for transcriptional regulation of RGC differentiation 1746 1745 3670 338917 PMC5454045__F2 FGF signaling pathway 2549 1848 1843 2118 2353 2115 3725 2119 PMC5454339__F3 Suppression of BCR signaling is detrimental to growth and sensitizes B-ALL to dex 3575 5296 6850 1445 695 6237 4893 208 2475 5605 1432 5594 4208 6929 PMC5457776__F1 Insulin resistance in obesity 207 3667 8660 7097 7099 PMC5458740__F1 ECM–cell communication is dictated by focal-adhesion players 1499 2932 6714 2475 PMC5460804__F7 Schematic drawing that illustrates the likely signaling pathway by which laminin A2 at the basement membrane regulates Sertoli cell BTB dynamics in the seminiferous epithelium of rat testes 207 208 6194 PMC5462861__F1 Nrf2 activation by misfolded proteins 9817 8452 7523 2539 PMC5463089__F2 Ubiquitination mediates the NF‐KB activation and nuclear translocation 673 8975 4286 7341 6613 4308 3091 6502 26272 595 4193 PMC5464927__F4 Regulation of Beta-catenin activity and function in cancer: therapeutic opportunities 4040 4041 2932 1499 8313 324 8711 10188 51176 607 PMC5464971__F7 “Tissue Development, Cardiovascular System Development and Function, Organismal Development.” This was the top most associated network according to IPA core analysis of the TM gene input set which included the microarray study by Fan et al 9049 7045 6695 1462 4256 652 26585 7057 650 2697 1305 857 858 6423 6422 59 4090 4086 10105 3710 4493 4494 PMC5465238__F1 Schematic outline of intracellular Ras signaling pathways in the suprachiasmatic nucleus (SCN) regulating circadian clockwork 2932 406 8864 1408 3726 5187 1958 2002 PMC5472795__F8 Anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites 999 8555 324 7398 545 9025 165918 55183 672 5888 PMC5473031__F6 Gestational exposure to sidestream (secondhand) cigarette smoke promotes transgenerational epigenetic transmission of exacerbated allergic asthma and bronchopulmonary dysplasia 596 406950 864 PMC5473728__F1 Schematic Overview of the Norrin-Beta-Catenin PathwayMutations in the genes encoding the ligand Norrin, the receptors FZD4, LRP5, and TSPAN12, and now the transcriptional activator Beta-catenin all cause FEVR 4041 8322 23554 324 PMC5474292__F3 Nodes linking the enriched KEGG pathway by hub genes 5054 1956 2185 4193 3164 4616 5617 6196 3565 4791 5608 4609 3725 2353 3667 4843 5468 1910 4000 3643 7083 4627 637 5347 1017 8945 PMC5475222__F2 Secreted T 7189 819 2920 100 53615 9112 1958 6772 4193 PMC5479446__F1 Schematic view of UPR response in mammals 22926 83939 7186 331 468 7494 PMC5479827__F3 Regulation network of the lectin genes related to immune activities 23274 394 55040 3654 4174 5627 4287 23624 161 1509 84971 3993 2319 4627 55718 993 4792 991 26253 10960 PMC5484415__F6 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy 6510 2744 375 2475 153129 PMC5485420__F10 Graphical representation for Mel regulation in DRG neurons 4199 5594 777 774 2903 2911 6095 4842 3553 PMC5486373__F1 MiRNAs involved in the regulation of autophagy-related signaling pathways 406979 57103 406936 406892 406987 1026 6794 7157 5728 406991 55332 80036 406958 407006 406994 3146 7249 7248 1027 3148 23411 406933 10645 353 6009 1017 407004 6199 406947 2475 1846 1847 253260 57521 406948 406921 8408 2309 7351 7020 693223 406996 139341 665 6774 406928 7048 3480 PMC5492985__F2 Canonical Notch Signaling Pathway: Structural And Biochemical Insights Into Shape, Sugar, And Force 3516 5927 8085 2146 221656 PMC5493710__F3 Improvement of the reprogramming process and replacement of c-Myc by small molecules and chemical compounds 652 7046 89780 PMC5493774__F9 SUMO pathway plays a crucial role in IBD: model representation of importance of SUMOylation in intestinal health and disease 4843 7128 85480 PMC5495050__F3 BRD4 pathway in acute myeloid leukemia (AML) cells 57680 54904 23476 7008 2313 2078 4609 1021 PMC5495965__F2 Predicted interactions among proteins encoded by genes expressed differentially in late proestrus 2893 18 6571 140679 2042 57084 5241 4929 7054 2099 367 6863 3814 1268 885 51083 135 552 7351 4922 2693 4988 6272 PMC5496044__F1 Schematic diagram of domain structure for LRP1 and LDLR 4035 1950 5045 3949 PMC5497057__F2 Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer 1956 5156 3643 10235 4763 5728 4193 1021 1019 472 7249 7248 1499 5925 7157 324 2475 6794 578 PMC5501999__F2 Abnormal kynurenine pathway and atherogenesis 7412 968 7038 4280 3949 348 PMC5503208__F2 Molecular mechanisms of dietary fat absorption within enterocytes 355 4099 2181 51703 54947 123 10226 27141 PMC5503214__F7 Dgat1 and Dgat2 regulate enterocyte triacylglycerol distribution and alter proteins associated with cytoplasmic lipid droplets in response to dietary fat 84649 8694 27141 338 PMC5503659__F1 Roles of long noncoding RNAs in colorectal cancer metastasis 441951 581 100885775 100316868 84740 5820 60674 652995 101867536 PMC5504949__F2 IL-6/soluble IL-6 receptor signaling at the nexus of endocrine function: illustrative examples 6774 6781 7054 7082 4280 6772 PMC5510573__F2 Overview of the human androgen biosynthesis pathways 412 4519 100187761 1588 PMC5514720__F2 Transcriptomic analysis of HBCs reveals that the Notch pathway is differentially regulated during activation from dormancy 28514 3714 4854 4853 10683 4851 4855 54567 8650 9253 4099 PMC5514964__F6 Regulatory functional territory of PLK-1 and their substrates beyond mitosis 79866 5347 983 5888 4661 7465 51512 10210 672 675 PMC5514966__F4 Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target 6774 5894 4851 1499 2146 6418 658 999 PMC5515553__F1 Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells 3976 5617 5618 3977 5163 207 3717 3716 6774 PMC5515859__F8 Proposed metabolic pathway of F18 in vitro 2328 2326 2330 1576 874 PMC5516276__F3 Genes uniquely modulated in Hhip+/− mice are involved in the connective tissue development and function network 54810 1101 4879 4883 4880 245812 26031 2264 5125 176 5594 9992 2012 3290 7122 79365 51705 4070 247 PMC5520455__F2 Schematic depiction of reported effects of mammalian caspases in autophagy-related effectors 55054 9774 9474 84971 10533 64422 PMC5520506__F1 PI3K/Akt signalling and its activation in cancer 3479 10000 207 208 5163 5728 PMC5520851__F1 mTORC1 controls cell growth and is regulated by the lncRNA-encoded polypeptide SPAR 3667 5163 5728 1977 8408 7248 23440 7249 6009 PMC5522257__F3 Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer 2932 26052 7409 5879 PMC5523465__F1a Checks and Balances: the Glucocorticoid Receptor and NFKB in Good Times and Bad 2288 2289 1325 2908 PMC5526580__F1 Impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer 3082 3479 3480 1956 2885 6774 2475 PMC5526991__F5 Extended Kegg Pathway for PI3K-Akt signaling 572 5728 1101 10319 1299 1298 1297 1311 2335 284217 22798 3381 3909 3908 3371 3913 3914 3918 3912 7058 7057 63923 5649 7059 6696 4193 7060 7143 7148 7450 7448 PMC5528323__F6 Pathways of steroid hormone synthesis, metabolism and tissue sensitivity to HRT (Kelemen et al., 2008; Pasqualini and Chetrite, 2005; Masson et al., 2010) MiRNA's predicted to target steroidogenic or metabolizing enzymes are encased in blue 2064 1956 23213 1429 1586 1588 1544 1312 1576 3292 1545 2938 991 898 5241 367 2099 1509 9134 PMC5538425__F1 Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy 5066 1445 929 7099 7096 7097 6850 54106 PMC5540801__F4 Shh pathway targets and regulatory networks 6926 639 9464 60529 91653 2520 57167 652 650 5727 6608 2114 2113 6469 2735 64399 2119 2118 PMC5541427__F5 Effect of selecting different subsets of CpG sites in the “TNF signaling pathway” 8837 6955 4137 3725 1208 574 83737 100187761 1363 175 PMC5541669__F3 Recurrent architecture of tumour initiation, progression and drug sensitivity 613 4615 51135 974 973 6850 7297 3716 84433 3654 695 6772 6774 7189 10892 8915 3662 2475 PMC5543893__F8 Involvement of KRT23 in the cell cycle: G1/S check point pathway 4088 4089 1051 1602 1026 25984 PMC5545069__F2 Iron Overload and Altered Iron Metabolism in Ovarian Cancer 55240 5093 8031 PMC5545727__F3 List of 24 CMMDh genes (left), genes enriched to the top canonical signaling pathways (middle) and the network of these genes with mood disorders and the CMD-Rs (right) 627 2778 5443 4524 776 3700 783 3952 3479 5978 348 150 6934 1463 1408 2932 153 79068 4544 7099 6570 3350 1385 PMC5546320__F5 Oxygen Availability and Metabolic Adaptations 8408 149428 664 665 468 64422 9474 10533 9140 PMC5547213__F1 Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy 10533 468 22926 1612 55626 9776 8408 PMC5551552__F5 Schematic summarizing findings and proposed mechanism of placental lipid metabolism in obese women 1628 8694 123 7038 5465 4519 PMC5553087__F1 Toll-like receptor (TLR) stimulation, signaling, and immunological outcomes 7096 7097 7099 114609 4615 10333 7189 7187 3654 29110 23118 3661 3665 51135 PMC5556034__F6 Simplified scheme of the enzymes and transcription factors involved in de novo lipogenesis pathway 31 2194 79071 PMC5557384__F5 Insulin-induced PI3K-Akt and MAPK network in hepatocytes 6464 6654 8660 2885 3667 572 2997 7249 6009 2998 7248 2475 1977 84335 47 221937 23367 10397 2887 PMC5559637__F5 H. pylori cag-T4SS-dependent, NFKB-driven innate immune response in gastric epithelial cells 80216 92610 10392 7189 PMC5562846__F1 Simplified scheme of chromatin changes in response to double-strand break (DSB) occurrence highlighting a central role of the ATM kinase 9025 165918 472 9656 4361 10111 PMC5564566__F6 Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC) 1950 3716 3717 3280 4854 PMC5564786__F6 MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3B/E-cadherin pathway 208 723778 2932 1499 PMC5566524__F9 TF-FVIIa-dependent PAR2-activated signaling pathway that accounts for Beta-catenin accumulation and expression of metastatic proteins leading to enhanced migration and invasion of human breast cancer cells 7018 324 2932 1499 PMC5566872__F8 Microglial responses to ischemia/reperfusion based on our in vitro and in vivo datasets 3627 7099 10379 6772 3454 6773 4940 11274 4600 6352 6360 PMC5567867__F1 Major steps in the HR pathway in budding yeast 545 5888 5893 PMC5569752__F2 Chronic effect of exercise on the ER stress-associated apoptosis and inflammation 22926 10628 114548 3553 581 PMC5569910__F1 The aryl hydrocarbon receptor (AHR) signaling pathway (A) is best known for the induction of xenobiotic metabolizing genes via activation by environmental toxicants 196 405 9049 PMC5570234__F2 MinePath viewer for BM20 region normal versus high Alzheimer's disease based on the CERAD classification 6772 3717 25759 2885 6654 3265 5894 5604 6418 5566 5590 107 2309 10000 1147 4792 4790 57580 2268 2770 23533 2931 5879 10681 408 9844 5058 56288 3702 10451 2185 998 407035 5747 7454 7018 387 6093 5829 5906 9564 1398 10235 23236 5579 653361 PMC5570578__F7 Illustration describing the role of HPV E6/E7 oncogenes and HPV E6/E7 siRNA with cisplatin (CDDP) plus paclitaxel (PTX) therapy on HPV-infected cervical cancer cell fates 7157 1017 545 472 PMC5571864__F1 Daily Rhythm in Plasma N-Acetyltryptamine 121278 7166 1644 15 9 10 438 PMC5573869__F5 Regulation of transcription factors by Pontin/Reptin 4609 2114 7015 1869 367 595 3091 10551 3553 79657 23118 1499 602 3094 26060 55198 PMC5573869__F7 Role of Pontin/Reptin in the EMT pathway 1950 1956 2475 6935 7448 1499 1000 9839 3091 6774 999 PMC5573916__F3 Simplified mTOR signaling network with interactions inferred from modeling approaches 1950 1956 3667 2549 7249 7248 PMC5575491__F5 Model of melatonin regulation of bone mass 438 15 7166 PMC5576859__F7 Distinct Functions of Argonaute Slicer in siRNA Maturation and Heterochromatin Formation 26523 11261 23237 PMC5578165__F1 The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts 472 1869 11073 5888 675 672 PMC5579704__F3 Proposed mechanisms by which dietary polyphenols inhibit EMT and cancer metastasis 3082 1950 999 5727 6608 1499 2735 PMC5580270__F4 Changes in hepatic gene expression associated with the PPARA signalling pathway and fatty acid metabolism between broilers (n = 6) and layers (n = 6) 335 31 4190 948 4199 57678 283985 5465 6256 6319 2194 2180 47 2168 4023 33 30 PMC5580928__F1 Post-translational Modifications (PTMs) that Modulate the Retinoic Acid-Inducible Gene I (RIG-I)-like receptor (RLR)–Mitochondrial Antiviral Signaling Protein (MAVS) Signaling Pathway 717 8780 1283 54941 9958 7706 6048 9960 27005 1540 10013 89122 51320 57506 7375 79845 29110 3661 PMC5581678__F2 Entanglement of GSK-3B, Beta-catenin and TGFB1 signaling network to regulate myocardial fibrosis 4087 4089 4088 4092 324 4091 5163 1499 PMC5581966__F1 The auto-immune attack to the beta-cells in Type 1 diabetes mellitus 324 920 3458 3654 7189 637 6772 3716 54472 4615 7186 8717 8772 355 PMC5582828__F2 Mechanisms by which fusion genes promote kinase activation and cell survival and opportunities for therapeutic intervention 613 25 64109 3717 581 PMC5584153__F4 Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis 2247 1950 3576 5728 572 595 PMC5584748__F3 Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information 1543 1544 1548 1559 1555 1562 1558 1577 9227 1576 100861540 1551 10170 PMC5587057__F2 Connectivity analysis of gene products differentially expressed by tissue type and menstrual phase 65243 23370 8797 8204 30011 974 6202 80150 3880 7704 6136 3932 11184 5087 8900 917 2099 6422 3560 31 919 5241 915 29904 6424 3003 328 923 3755 2203 5551 3820 80342 28999 3488 2078 3426 2215 3824 10882 2791 10578 6943 1230 51513 1848 2999 3957 3706 54810 7450 54345 6368 1003 5799 11142 64344 3397 57575 6358 2823 55638 23554 1906 55008 6804 55901 10203 4685 80323 79605 3399 79698 3977 10846 7102 10268 10800 50650 10267 10266 PMC5588408__F1 Canonical and noncanonical inflammasomes 3454 22861 9447 114548 140609 4671 58484 3553 3603 PMC5589626__F7 Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRA/AKT cascade restrains tuberous sclerosis complex-associated tumor development 5156 3667 5728 5163 7249 7248 64223 2475 64798 PMC5591558__F3 EGFR cell signaling and lncRNAs relationship in lung cancer therapy resistance 1956 3480 2885 3667 2549 5728 60674 2475 554202 PMC5593690__F1 PI3K/Akt pathway: a critical player in intervertebral disc degeneration 5728 2932 6009 64798 572 581 595 1977 PMC5595144__F2 Dendritic cells (DC) can either activate adaptive immunity or tolerize T cells depending on their state of maturation 6774 3902 920 151888 PMC5595802__F1 Melanoma (Skin) tumorigenesis pathway, collected from KEGG 673 595 1019 572 5728 4286 PMC5596442__F2 Two strategies for photoactivation of cell signaling pathways 1408 4827 5266 PMC5597216__F1 Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages 1356 7422 5617 51083 2488 3558 2099 7200 284217 5443 2691 1081 8022 1404 3972 1363 7432 1958 8648 3481 5578 PMC5597599__F2 Model Signaling Network 3717 9021 5728 4170 3091 PMC5597640__F9 Model for replication stress and its aftermath in the absence of BRCA2 675 5888 4361 PMC5599801__F1 Modulating NAD + metabolism, from bench to bedside 142 952 93100 203447 4837 23475 130013 PMC5599913__F1 The SMC1 participating in DNA damage repair signaling pathway 4361 10111 672 472 56852 9656 PMC5601168__F2 Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy 5318 1832 1499 4771 847 2932 595 PMC5601664__F7 SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells 29843 26168 205564 59343 6774 998 5879 2002 6613 26054 57337 PMC5601978__F4 Physiological functions of ataxin-2 6311 1981 1977 26523 1999 3708 6095 3632 2475 6194 PMC5606034__F4 GPR and HDAC co-regulation network related to epithelium growth 427 83933 56848 57568 10013 5467 9759 653519 8649 5335 151556 4296 23683 10014 2002 5986 PMC5606335__F6 Oxygen-dependent regulation of antioxidant production by HIF1 2539 26227 29968 5723 6470 6472 10797 4522 25902 PMC5607088__F1 AT1 receptor signaling pathways in the cardiovascular system 6868 1950 1839 1956 5894 2475 1977 PMC5610219__F2 Multiple miRNA biogenesis pathways 4922 29102 51808 7514 57510 27161 26523 192670 192669 PMC5613059__F1 Frequent genetic alterations of PI3K/mTOR signaling pathway in HNSCC 1956 5290 5291 5163 5294 5728 5293 7249 7248 6009 5563 5562 253260 1978 1977 PMC5614474__F2 Multiple and bidirectional connections between actin dynamics and endocytosis 3082 7074 382 857 57111 PMC5617400__F4 Autophagy-related gene expression is an independent prognostic indicator of glioma 2624 93986 2099 57630 10664 4296 3660 50943 51100 6929 1879 9474 5468 6239 7405 5599 1874 5601 3659 2475 9776 8678 22863 9140 83734 10533 64422 100170220 PMC5618535__F2 PALB2 in the DNA damage repair 472 79728 672 1763 9156 545 675 5888 PMC5620223__F7 EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer 1950 4838 1956 4087 4088 4089 PMC5620326__F4 Roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis 50507 6774 5879 602 3383 PMC5620554__F2 TRIMs in cytokine signaling 3717 3716 4615 3654 8717 7186 117854 3093 81603 6772 6773 6774 10475 5987 10401 8805 10155 7297 23118 257397 PMC5621151__F1 TLR-signaling pathways 7099 7097 51135 7187 3654 7098 7189 929 23118 29110 3661 7124 6352 3627 4615 4118 PMC5622528__F9 Hexokinases link DJ-1 to the PINK1/parkin pathway 3480 3667 5163 5728 2932 3099 3098 PMC5628821__F6 Design and validation of a 90K SNP genotyping assay for the water buffalo (Bubalus bubalis) 9378 90523 5371 375444 57586 4000 29095 9777 22838 7673 54807 10873 79086 56948 55762 55214 284129 29942 3172 54834 29100 84138 152756 27283 60526 60625 84910 79922 PMC5636111__F5 Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia 9455 5290 2259 3552 10000 5600 5880 5923 6196 7189 3265 100137049 111 2773 80854 2308 5568 998 11345 2775 1398 2904 2916 5567 PMC5638382__F1 Different endothelial responses to different patterns of flow 387 10365 9314 1386 1958 PMC5641361__F4 Cell signaling pathway scheme of metabolic alterations due to Zika virus infection 59272 5476 1359 1636 4311 4142 200576 5163 2475 PMC5643752__F2 Hinge-latch model of Nrf2 8452 9817 4094 3725 1728 PMC5646121__F3 Direct and indirect targeting of the B cell receptor signaling pathway 613 930 974 6850 695 29760 5336 2475 PMC5646997__F2 Schematic representation of the effects of glutamate excitotoxicity, energy metabolism deficiency and axonopathy in ALS pathogenesis 10371 627 6405 PMC5647180__F4 Identification of differentially regulated genes within the cellular assembly and organization, cellular function and maintenance and cell death and survival network 375790 55684 10598 5170 23336 10383 8406 29078 22822 4208 PMC5650369__F8 Fasting inhibits colorectal cancer growth by reducing M2 polarization of tumor-associated macrophages 6774 3716 9474 PMC5653411__F1 Apoptosis and necroptosis as host defense strategies to prevent viral infection 8717 8737 7098 115004 11035 3661 581 57506 8772 197259 PMC5653760__F6 Resveratrol has multiple biological functions that are relevant for AD 2475 4281 23621 102 351 PMC5657403__F1 Regulation of the intrinsic pathway to apoptosis by B‐cell‐lymphoma‐2 (BCL2) family members 8739 637 572 90427 638 596 4170 581 PMC5659283__F2 PTEN controls the G2-M transition to prevent bypass of the G2 checkpoints and premature entry into mitosis (M) 545 5728 7153 891 983 55743 PMC5660598__F4 Dexamethasone (Dex) and monphosphoryl lipid A (MPLA) treatment leads to changes in the expression of genes involved in biological processes associated with immune response regulation 246 140 5360 8771 2212 6280 6279 2357 6648 6374 6352 929 2205 7057 6362 4360 1043 4502 199 9636 1880 114897 2114 100133941 3575 4609 481 3669 653361 247 PMC5662062__F4 Replication Stress Response in Mammals and Trypanosomatids 3364 5810 84126 545 11073 PMC5662721__F4 Type I interferon pathway gene network predicted by IPA analysis 3929 3156 145264 2167 10631 4254 1385 1149 91543 4826 10153 9321 9497 5266 9128 10553 546 4151 5728 64129 2744 5586 5584 3845 PMC5663315__F1 Schematic representation of the mTOR signaling pathway before discovery of TSC function 2475 3630 3667 201163 2887 7249 7248 6009 3091 6774 PMC5664079__F1 Major signaling pathways in chemoresistance and PDK1 implication 5163 10645 1301 92140 PMC5665066__F1 PolyI:C induces tumor necroptosis via the TLR3 -TICAM1 pathway 7098 148022 57506 29110 3661 197259 PMC5666810__F2 Thrombin cleaves the amino-terminal domain of PAR1 and triggers intracellular signaling 4318 3553 2475 387 PMC5667900__F4 Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway 23657 6520 2182 6935 10162 2879 3077 PMC5668145__F5 Steady-state levels of TCA intermediates in control and KO livers and tumors and the expression of key enzymes in the glutaminolysis pathway 1506 27165 2597 1431 PMC5669051__F4 Endocannabinoid System in Neurodegenerative Disorders 2548 275 4018 2695 26191 PMC5669621__F1 Development of POMC neurons 5443 6774 627 3280 6469 7080 6496 30062 4852 6657 1270 PMC5670149__F1 Wnt/Beta-Catenin Signaling 4041 4040 4087 324 1499 3611 4089 4088 PMC5670164__F1 Sonic hedgehog (Shh) signaling pathway in a mammalian system 6469 3549 50846 57758 6608 64399 11127 PMC5670164__F3 Regulation of thyroid cancer stem cell (CSC) self-renewal by the sonic hedgehog (Shh) pathway 6469 6608 2475 2735 648 1435 79923 9314 79727 PMC5674931__F4 The interactions between microRNAs (miRNAs) and cell death-related proteins in drug resistant cells 355 596 9474 578 84971 PMC5676564__F1 Representative signalling pathway of human TLRs in the cell membrane (TLR1/2, TLR2/6, TLR4, TLR5, and TLR10) and endosome (TLR3, TLR4, TLR7, and TLR9) 7097 7099 10333 81793 54106 4615 4118 51284 7098 51135 3656 29110 23118 257397 3661 3665 PMC5676684__F6 Network of miR-93 and miR-21 with putative target genes of important signaling pathways from KEGG enrichment analysis 22800 7057 6667 245711 1956 5154 55970 166336 4208 4763 5781 5295 1399 79718 5921 4915 9765 9021 1499 5578 1386 4089 81839 1398 7027 6195 7534 8454 656 5791 10000 6654 6789 387 324 57154 5577 3643 9475 5532 5567 5494 6422 10019 23291 9693 22808 5495 5256 6907 5933 10971 3624 775 4776 5515 2997 2033 3845 4775 572 51347 659 1488 5608 4217 PMC5679221__F1 Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia 998 5879 3611 387 2534 PMC5679221__F2 Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia 2534 2885 3479 3611 5879 998 2475 PMC5680920__F8 Schematic representation of the regulatory mechanism about PLOD2 was summarized 7039 1950 1956 3169 5352 PMC5681735__F1 Kynurenine pathway (KP) 169355 3620 23475 PMC5681992__F3 Schematic overview of the bile acid signaling pathways to the central nervous system 2261 2260 2263 2264 4922 9965 PMC5682418__F5 Selected miRNA-mRNA interaction networks involved in Jak-STAT signaling pathway 1271 1439 4170 596 6774 3717 10379 5292 3977 9049 2475 PMC5682923__F1 Complex Roles of mTOR in Adipocytes and Beyond 2887 5163 7942 5728 201163 6009 153129 PMC5683946__F6 NMD and apoptosis have a complex regulatory relationship I 1647 60674 5976 6446 85451 4149 1386 PMC5685659__F7 Diagram showing LMP1 signaling transduction to IRF4 activation 3662 5163 8837 PMC5685850__F4 Wnt receptor signaling pathway and regulation of Rab GTPase activity involved in miRNA expression 1499 4089 6422 5601 5467 56998 23401 1387 8945 5568 1857 81839 5880 4773 57216 5578 79735 254272 9905 125058 PMC5686191__F8 Possible mechanisms underlying how YAP regulated LRP1 by promoting proliferation and metastasis of melanoma cells and also reducing apoptosis 4035 4318 4313 PMC5687841__F6 Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis 1950 7124 4803 4049 7039 4055 114609 4615 3932 7535 23118 257397 5970 5971 5966 7415 5055 8877 6385 11343 PMC5693226__F1 Rationale for mTOR inhibitor + NOTCH inhibitor combination 54567 3280 5728 10247 2475 PMC5694782__F1 Critical DDR Pathways for UV induced DNA Damage: (1) UV induces an intrastrand lesion, causing the replication fork to stall in S-pase 545 84126 11073 353497 5426 5111 5888 675 672 472 PMC5696061__F2 Rethinking HSF1 in stress, development and organismal health 2475 23411 3297 23644 55294 3479 PMC5697340__F1 Stages of innate lymphoid cell (ILC) development 8320 2625 3398 6932 9760 4783 7704 10663 3559 PMC5697417__F2 IFITM proteins are involved in various cellular processes with direct and indirect impacts on immunity 3479 3630 857 9531 128486 6714 55626 2475 3661 PMC5698505__F3 mTOR signaling 5728 5163 7249 6009 3091 PMC5701999__F3 Two arms of the insulin signaling pathway in skeletal muscle cells 6844 6810 5163 23216 5879 5058 PMC5702629__F5 Enriched canonical pathway for toll-like receptor signaling at 48 hps with dsRNA 7097 7124 114609 3929 929 51135 7099 7189 130749 54106 3661 7098 PMC5703693__F3 Molecular mechanisms of the attenuation of PI3K and Akt, and the dysregulation of PI3K/Akt signaling pathway by gingipains 5163 3431 572 2475 PMC5703744__F1 Two major pathways in the cellular folate cycle 1719 6470 4524 471 5471 2618 635 4548 4552 100 PMC5703970__F3 C-T-P network 5742 5743 4846 7124 4137 4843 351 4318 2147 2890 3356 2904 107 4313 3315 801 4923 186 706 5580 PMC5705614__F1 The core elements of the mammalian Hippo signaling pathway 8491 9448 11184 5871 4485 60485 9113 26524 55233 92597 983 9686 PMC5706558__F1 Strategy for analysis of ERBB2-driven gastric cancer 6418 10993 2064 2885 1956 4609 PMC5707523__F1 Viral modulation of death-receptor mediated apoptosis 7124 355 8772 8717 7186 581 PMC5710110__F3 Transforming growth factor B (TGFB)-induced transcriptional program and its alterations in cancer 4089 4088 2290 983 1874 4609 467 PMC5711888__F3 A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis 10365 7422 6774 8829 6714 7474 7424 7476 441478 23462 4087 2277 4091 4086 1499 27302 7040 PMC5712254__F1 Metabolic Advantages and Vulnerabilities in Brain Metastases 3099 5226 2539 5214 6888 22934 5163 2744 PMC5713154__F4 Cell signaling pathway scheme of metabolic alterations due to Zika virus infection 59272 5476 1359 1636 4311 4142 200576 5163 2475 PMC5715835__F3 Molecular interactions and outside versus inside cell identity 1045 7004 8320 2625 999 1499 79923 PMC5717492__F8 EMT signaling induced during P 999 2932 4313 6935 1499 PMC5721467__F4 Upstream regulators and downstream biological effects predicted by Ingenuity Pathway Analysis on the proteome level 7040 5997 4088 633 3598 3486 5592 8644 1440 50507 4067 6648 7185 PMC5721467__F9 Regulatory network elicited by nuclear translocation of syndecan-1 leading to inhibition of proliferation and survival 5077 6667 81704 PMC5721733__F8 Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway 6648 23410 114548 PMC5727308__F1 WNT signalling pathways 1499 324 2932 4920 4919 23002 387 5879 PMC5727324__F1 ‘Two endocytic routes and two outputs model’ in the Wnt signalling pathways 89780 4040 7474 22943 4920 857 324 1499 6925 PMC5727324__F4 DKK1 and CKAP4 signalling axis 22943 5548 10970 PMC5728441__F1 Found in translation: how preclinical research is guiding the clinical development of the BCL-2-selective inhibitor venetoclax 572 581 8739 638 637 PMC5729527__F1 Simplified version of the key factors within the Hippo signaling pathway 4485 26524 9113 7018 PMC5729908__F9 m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway 3575 3716 3718 56339 3574 PMC5731985__F2 Mesenchymal stem cells in idiopathic pulmonary fibrosis 9242 3576 7852 1499 PMC5732723__F4 Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome 2149 7035 2152 1361 2155 2159 2147 2160 2158 2157 7450 7056 2 5624 5327 5329 5328 2161 928 718 730 735 729 1431 717 720 1380 PMC5733215__F4 STAT3/S1P/S1PR1/SPHK1/SPL-positive feed-forward loop promoting CAC 124976 8877 6774 1540 5728 1901 PMC5733726__F1 Inborn errors of immunity underlying fungal diseases in otherwise healthy individuals 64170 84818 149233 3466 3265 5923 8915 10892 6774 6772 10682 3553 2919 4312 3716 3717 PMC5735743__F3 MTG16, and other MTG family members, may play a role in the constitutive repression of both Wnt and Notch signaling pathways 1499 6925 4609 441478 PMC5735915__F8 The c-Myc/miR-200b-3p/PRDX2 regulatory loop 2932 1499 208 7001 PMC5736922__F1 Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications 222545 27035 50507 79054 PMC5740609__F2 Cellular processes altered by colonization by a heterologous symbiont: (A) oxidative stress response; (B) molecular signaling pathways; (C) sugar storage, transport, and signaling; and (D) lipid and protein metabolism and transport 225 5826 2180 2182 747 8694 2937 2729 2917 6608 6865 23432 2632 10892 162417 117247 PMC5740757__F4 Interaction pathway of miR-1270 and target genes 64764 23216 2550 5170 9706 157 8844 1398 3643 55534 408 11140 83737 2355 6654 4067 5062 1857 9586 9846 6789 6667 2771 3394 83593 6773 57580 64098 6907 5613 PMC5742588__F3 The folate cycle is fueled by the serine synthesis pathway (SSP) and extracellular serine 5723 29968 6472 6470 4522 160428 PMC5742799__F2 Hypothetical model for the proposed anti-inflammatory role of MUC1 in response to P 7124 7039 4615 3654 51135 7189 6667 4582 7100 1956 PMC5744163__F1 Three types of autophagy and regulatory mechanisms 2475 8408 9776 7405 22863 55626 596 9474 9140 64422 PMC5745276__F3 Cross-Talk between the Wnt, Notch and Sonic Hedgehog Pathways- Beta-catenin can drive activation of Notch signaling by increasing expression of the JAG1 gene, which encodes the Notch ligand Jagged1 6469 6608 182 2713 2735 6422 1499 PMC5747488__F13 Parapoxviral virion protein targets the retinoblastoma protein to inhibit NFKB signaling 8717 7186 10454 23118 257397 PMC5749411__F4 Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development 355 8772 8717 637 7186 2021 9049 4615 6955 572 472 581 717 PMC5751361__F12 TGFB signaling pathway 2885 4087 4088 4092 4089 PMC5751940__F1 TumorMap framework and application to the analysis of the TCGA Pan-Cancer-12 Dataset 140821 3815 2114 3725 3091 2113 1959 4772 2353 5579 3932 5788 1523 7157 PMC5755720__F1 ERBB signaling in CTCs of ovarian cancer and glioblastoma 1950 5728 3717 2885 6774 5163 2475 4609 3725 2064 2065 2066 PMC5757216__F1 Circadian clocks: from stem cells to tissue homeostasis and regeneration 64065 26224 8863 8864 1407 1408 6096 7008 1628 9575 3131 PMC5758399__F2 Top section: Mechanisms responsible for the cytoprotective and anti‐inflammatory effects of PARP inhibitors on non‐oncological diseases 81847 8505 3725 2353 6352 6347 6741 200558 11284 3980 2932 1499 7088 1643 7518 PMC5764254__F7 Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src 6714 2932 1869 1499 468 PMC5768349__F7 Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics 84962 1356 2044 55022 1942 81792 10371 3569 121512 5166 958 942 117177 85451 28737 10659 PMC5770609__F2 Wnt signaling pathway leads to the accumulation of Beta-catenin in nucleus 2932 1499 324 PMC5770878__F6 The hypothesized protective effect of CR on retinal degeneration by ONVT: the pivotal role of elevated endogenous 3HB via ketolysis 1431 622 38 1728 PMC5773178__F2 Signalling pathway impact analysis of gene expression data from H226 MM cells expressing C91A-mutant (mt BAP1) or wild-type BAP1 (wt BAP1) 2242 8772 8717 7186 637 4615 572 472 7939 4803 PMC5773610__F7 Mechanism of anti-allergic and inflammatory effect of quail egg on the food allergy induced EoE like disease alergic reaction 85480 3600 920 3569 PMC5777758__F5 Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors 983 1019 1021 1029 1017 1030 PMC5779870__F1 The PDGF signaling pathway 387 5163 3716 5728 100033819 1051 6772 PMC5783486__F4 Network of differentially expressed proteins in KD with CAD and CAA 4018 338 1071 5360 348 3931 335 3493 3263 336 213 3250 721 4153 1893 2147 629 5624 718 3075 2161 3483 1191 350 7448 735 3827 26998 6418 5552 462 2 720 2243 2266 710 3053 5340 727 2244 5265 2165 3273 2335 PMC5783597__F7 Schematic diagram of the CCL2/CCR2 axis activating Hh signaling 6469 6347 729230 5727 6608 2735 PMC5784573__F2 Radiation effects on antitumor immune responses: current perspectives and challenges 355 115004 472 718 3146 728 719 7099 941 942 940 58191 6347 3383 7412 PMC5784915__F7 Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks 9833 994 1031 5111 890 983 4171 55872 6241 10926 9700 2335 2237 2305 1894 29127 55165 9212 641 29899 6790 10403 11004 26586 7443 83461 83879 891 51514 55143 10615 100379198 PMC5788639__F6 Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement 3479 2099 207 673 595 PMC5790278__F7 Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma 3717 9021 2475 6774 4035 PMC5801557__F1 Parathyroid tumorigenesis mechanisms via the cyclins pathway 595 79577 4221 1027 PMC5803173__F1 Striated sarcomere structure and TTN-mediated signaling pathway 2273 2274 4077 8878 PMC5806108__F1 NSAIDs significantly induce autophagy 3082 9140 9474 10533 2475 PMC5807041__F11 Top deregulated networks in NL-20 cells: Hematological system development and function, immunological disease, lymphoid tissue structure and development network induced by Caki-2 cells defined by Ingenuity Pathway Analysis 144203 4311 2690 9743 83478 8945 8672 2241 159296 140691 5435 7013 11107 PMC5807041__F17 Deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder, developmental disorder networks induced by ACHN cells defined by Ingenuity Pathway Analysis 5046 5284 6609 26086 8473 5469 3516 27125 4297 56949 29915 3607 PMC5809511__F4 Non-canonical Wnt signaling at the primary cilium 27130 57216 7976 54903 387 PMC5810588__F1 Reciprocity in ROS and autophagic signaling 10628 10533 5728 64422 9140 55054 83734 9474 8408 10133 5266 10645 3146 472 7942 5289 PMC5811474__F5 Illustration of E3 ligases and DUBs that regulate TNF induced NFKB pathway 27005 10869 23118 7189 1540 81858 84231 64236 51147 7874 8717 8772 7186 7188 90268 5987 PMC5812366__F1 Major mechanisms of therapeutic resistance to androgen axis-targeting therapies in prostate cancer 1950 3479 7046 367 581 4087 4088 596 5728 4089 4193 2475 8805 PMC5814228__F6 Deciphering microRNA targets in pancreatic cancer using miRComb R package 8650 2033 151636 23220 3280 388585 23385 6868 PMC5814270__F5 Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas 3977 3572 3976 1489 207 1956 983 28984 PMC5815915__F8 Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis 50507 637 572 596 6648 2002 2729 PMC5817863__F1 Schematic view of the circadian pathway 8914 9575 1407 4862 5187 6096 6095 9572 1454 PMC5817867__F2 RTK-regulated signaling in breast cancer progression 2064 1956 4609 7291 4838 90627 6657 PMC5818153__F1 Sphingolipid metabolism in cancer signalling and therapy 10558 253782 29956 204219 10715 79603 91012 6609 1674 6611 5091 64781 8877 56848 PMC5818417__F2 Anti-fibrotic effect of selected polyphenols 50507 4087 4088 4089 6722 PMC5818912__F4 The ADAM17/EGFR axis 4851 6868 374 1956 PMC5818965__F1 Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines 7124 6347 6346 2920 6352 2921 6846 PMC5821264__F2 Regulation of Signal Transduction by DJ-1 6714 7249 7248 6009 2002 6647 7054 1843 PMC5821468__F5 Severe congenital neutropenias 7852 1130 5873 8546 84522 92579 157680 204 10456 51119 2624 2672 7454 PMC5823660__F3 An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice 22926 7186 468 7494 811 821 596 PMC5824027__F1 Hippo Pathway in Cancer Stem Cell Biology 4485 9113 26524 22943 7474 7042 374 9686 PMC5824910__F1 G-alpha signaling pathway in uveal melanoma 2776 5728 7204 6010 154796 2475 PMC5825896__F9 Schema of the anti-HIV mechanism of toll-like receptor 3 (TLR3) signaling of intestinal epithelial cells (IECs) 3661 9636 3665 4284 1234 920 7098 PMC5826840__F8 Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway And Aggravates Hepatocellular Damage In Mouse Ischemic Livers 7099 4615 4851 5728 7189 6093 836 3280 85451 PMC5831768__F2 Non-canonical Shh signaling in commissural axon guidance 2817 6469 64399 6608 91653 PMC5831775__F2 Simplified scheme of the cilia-mediated HH signal transduction pathway in vertebrates 374654 2932 6608 PMC5832136__F6 Anti-liver cancer mechanism of TF 7018 5728 581 572 PMC5832166__F7 TGFB1 signaling in hMSC differentiation 2247 6655 3845 2934 4478 1959 4209 5327 PMC5833788__F7 NIT1 and TGFBeta-Smad2/3 signalling pathway in colorectal cancer 7040 4817 4089 4087 4088 7018 PMC5835092__F3 Ingenuity Pathway Analysis (IPA) for Jab1/COPS5 regulation network in cancer 4089 4092 3725 7295 10987 1499 4792 3569 1956 9611 6774 7157 602 5728 3091 4790 596 4282 PMC5835092__F4 Ingenuity Pathway Analysis for the interaction between Jab1/COPS5 and PD-L1 100423009 100500819 836 10987 142 7124 6279 7297 6772 5970 3725 6774 2932 3091 PMC5835092__F5 Ingenuity Pathway Analysis to predict the effect of chemical drugs on level of Jab1/COPS5 4790 1499 7157 142 4092 4089 10987 7295 6774 3725 PMC5835698__F2 Antitumor mechanisms of ivermectin 324 8313 9474 3669 3434 8549 10379 3433 84164 8638 11259 3146 5058 1499 2475 9416 960 79923 6657 100133941 PMC5836077__F4 Agrin stimulates integrin-FAK-ILK-PAK1 mechanosignalling pathway to antagonize the Hippo pathway and activate YAP/TAZ mediated gene transcription 3611 5058 387 4771 4485 9113 26524 PMC5836465__F3 Unfolded protein response 22926 7186 83939 581 596 468 PMC5839790__F1 Classic autophagy compared with related trafficking pathways 8408 9706 9776 22863 10533 64422 55014 9474 9342 8673 3603 3146 6809 6810 8773 9711 7405 9554 PMC5840209__F3 Apoptosis signaling pathways 2492 654 638 581 4170 572 PMC5840987__F1 Canonical and non-canonical Wnt signaling pathways.(Left) Unstimulated Wnt pathway results in constitutive Beta-catenin degradation 1499 4041 4040 6259 4920 2932 5879 387 324 3725 PMC5841164__F1 PTEN signaling in Treg cells 324 920 8829 5163 5728 50943 2308 7908 PMC5841291__F8 Sotetsuflavone inhibits non-small-cell lung cancer cell invasion and metastasis 2475 999 1000 PMC5843510__F8 Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity 8660 8471 2549 PMC5843704__F8 Proposed model for the role of DAPK1‐mediated Beclin‐1 phosphorylation and TTP‐mediated Bcl‐2 mRNA destabilization in autophagy leading to the suppression of inflammatory responses by gAcrp in macrophages 51094 1612 7189 4615 PMC5844144__F1 Ferroptosis-associated metabolic networks 875 4199 3652 2539 5226 2879 2182 31 10162 PMC5845557__F2 Invariant NKT (iNKT) cell activity within the tumor microenvironment (TME) 912 8205 3002 324 3458 PMC5847475__F2 Mechanism of PD-1 and PDL-1 pathway in tumor environment and the complex crosstalk between cancer, tumor, T-cell, APC and macrophage and tumor stroma 324 8205 285704 3082 PMC5854489__F3 Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma 64802 349565 23057 55191 10135 PMC5854644__F9 MicroRNAs (miRNAs) related to the epigenetic control of genes involved in demyelination, epithelial–mesenchymal transition (EMT), inflammation, pain, and loss of sensation were differentially expressed in leprosy patient (LP) 960 7040 6591 999 7042 4087 4088 3217 6663 7046 55914 5894 1432 6662 207 5879 3845 998 6093 387 9839 6935 3725 476 4208 358 2064 10280 7442 3215 3218 3224 PMC5854649__F1 TLR4 signaling pathway 7099 54472 7189 51295 23118 3553 929 695 4118 4615 10454 51135 3656 PMC5855642__F1 Sphingolipid signaling pathway 8877 1903 5640 PMC5855681__F2 MicroRNAs regulate gene transcription 26523 2146 23512 7528 29102 54487 PMC5858164__F7 Working model of endothelial specific elevated miRNA302-367 attenuating embryonic hindbrain developmental angiogenesis by targeting CDC42 and CCND1 multiple pathways 998 595 1021 1019 2885 5058 1869 PMC5858703__F1 Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease 38 3157 3156 2222 6713 4047 1595 7108 10826 50814 51478 10682 6309 1718 1717 PMC5858916__F7 Rotavirus infection 3454 3455 7297 3716 6772 57506 10379 6773 29110 3661 8945 PMC5859839__F3 Pathway of ER-positive breast cancer target PPI network (blue circle stands for breast cancer gene; red diamond stands for pathway) 595 1956 1950 3479 5290 2475 4602 4609 2736 6714 10413 6777 7157 3717 5743 2001 3791 23411 1977 5347 5058 2099 5520 2100 596 PMC5859976__F1 Screenshot of PathwayMapper 3480 8821 1956 5728 5295 3717 5266 572 6016 6195 9451 208 207 5604 10000 PMC5860940__F2 Simplified overview of the intracellular signaling mechanisms governing CCA cell motility and invasiveness 2932 55294 2475 6275 57167 648 5728 6935 6662 PMC5863305__F1 Role of miR-146a in diabetic microvascular complications 7189 4851 2066 6774 3656 3654 1356 PMC5864190__F1 Models of RIPK1 regulation by IKKA/B and MK2 phosphorylation 8737 7124 7099 PMC5864197__F7 Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection 93129 6446 4193 1878 8178 PMC5866970__F1 Components of the Hippo/YAP pathway 4485 9113 26524 PMC5866970__F3 Regulation of the Hippo pathway in smooth muscle cells 595 6010 3491 7042 4609 4485 PMC5867295__F2 Wnt- and TGFB superfamily signaling pathways 26585 2487 4148 7473 6422 22943 4090 4086 10454 8313 2932 324 64750 4089 1499 2146 4041 6925 51176 1386 56955 249 1300 860 6662 3397 4040 PMC5867880__F3 CD99wt and CD99sh in tumor cells 4267 857 9475 4318 PMC5868594__F1 Nuclear factor kappa B and its activation mechanisms 6007 5970 5971 PMC5868815__F4 In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases 324 8313 10000 595 572 387569 842 3725 673 5604 3845 2353 5594 836 5900 5879 7042 4088 4089 7048 4397 2956 596 54205 367 5728 2950 1017 5925 5765 1871 1026 5163 5290 1950 4193 1387 2885 6654 1499 6716 51176 3551 4790 2475 7184 PMC5869054__F5 ABeta-driven Wnt-PCP pathway activation 2931 1499 4040 4665 22943 1958 7071 57216 23002 387 PMC5869671__F1 NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival 958 4055 5971 8729 79176 PMC5869932__F2 Roles of ZBTB proteins in B-cell development, differentiation, and function 27033 5091 26137 604 51341 7709 22890 9841 10113 3575 7157 1879 596 5079 639 3662 PMC5871897__F8 KYA1797K as a potential strategy to overcome resistance to EGFR targeting drugs in CRC 4040 4041 2885 1956 324 2932 8658 1499 2695 PMC5872768__F1 Possible routes of lipid oversupply-induced insulin resistances associated with mitochondrial and endoplasmic reticulum (ER) stress 9927 10936 55669 3667 PMC5873813__F2 Broad overview of the genetic architecture of inflammatory bowel disease giving examples of confirmed and candidate genes implicated in each pathway 7494 11132 94103 64167 64127 55054 345611 7099 120892 8897 149233 4485 1235 6774 8771 246778 3717 23308 7297 4088 117289 2524 PMC5876636__F2 TGFB1 signaling via SMAD-dependent/independent pathways 7040 5352 7070 1462 PMC5876639__F1 Involvement of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) in DNA damage response pathway 238 472 545 4193 PMC5876722__F1 Oncogenic signaling networks by Kaposi’s sarcoma-associated herpesvirus 5335 7249 7248 6850 1977 1975 PMC5877395__F1 Annexin A2 (ANXA2) in cancer progression 5340 1000 302 6281 6657 84299 79923 PMC5882306__F7 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells 83939 100506742 2021 468 56616 596 842 331 836 PMC5882318__F1 Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway 5163 5164 2475 PMC5882332__F3 Signaling lymphocytic activation molecules Slam and cancers: friends or foes? 619501 1950 2475 5347 PMC5883416__F2 Calcium in cell cycle G1/S transitioning via the MAPK pathway 5925 595 1019 PMC5884027__F1 Schematics of the metabolic pathways and their cellular localization affected in branched-chain organic acidurias and homocystinuria disorders mentioned in this work 6948 51293 4524 5826 23624 867 27249 4552 875 1629 593 326625 868 594 1738 10295 5095 5096 5091 PMC5885760__F2 Microbiome series 2328 51076 4088 PMC5887227__F9 ScRNA-seq profiling on progenitor cells and hPSCs 79923 9573 2353 3397 4838 7546 100133941 9421 5080 6591 63876 6926 5077 84159 3198 1044 6299 7020 4208 54897 4212 5396 947 70 4060 174 3791 10630 5015 2244 641700 7022 5764 5350 PMC5888808__F1 Programmed death-ligand 1 (PD-L1) is the ligand of programmed death 1 (PD-1) receptor 3458 238 1956 3716 6714 6774 6772 10413 1020 2475 3660 359948 5696 5698 1786 PMC5890336__F1 Canonical PI3K/AKT/mTOR signaling pathway 2064 2065 3667 5728 64798 7249 7248 6009 9776 1977 PMC5891947__F1 Potential LMTK2-related neurodegenerative mechanisms in Alzheimer’s disease 22853 2932 4087 PMC5897151__F3 Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease 6720 7942 65018 23400 120892 216 2597 217 4118 PMC5897502__F1 Antigen receptor signaling in naïve and anergic B cells 5728 4067 6850 1445 26191 PMC5897904__F2 Genes mapped to the IL-6 pathway by IPA Software 7186 10454 9261 2353 6722 1401 PMC5903677__F3 Therapeutic targets for brain injury for nanoparticle mediated drug delivery 594857 627 2056 PMC5904076__F2 HSPs and the DNA damage response (DDR) 84126 3014 545 3315 472 3297 PMC5904274__F3 Molecular mechanisms of ZIKV underlying the neuropathogenesis 10410 5728 7297 7706 6773 6772 10379 7249 2475 6009 2152 3716 PMC5905132__F2 Adversarial functional module (AFM) pairs 6010 85415 30851 6242 1175 5516 160 1759 1212 163 1173 867 PMC5907833__F3 Regulation of KLFs in ECs 4047 8462 10365 9314 PMC5908625__F2 Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis 1062 641 7298 147179 2963 5725 6453 10109 24148 51585 80335 5217 1949 2051 29894 10097 2050 1947 8976 10914 11065 10291 PMC5909795__F2 The Hippo pathway regulates organ metastases by controlling cell proliferation, EMT, and immune evasion.Abbreviation: EMT, epithelial–mesenchymal transition 60485 4485 9113 26524 PMC5910322__F6 Pro-apoptotic mechanisms of miR-217-5p regulating the ERK-MAPK pathway at different sites 3685 2885 3845 5584 9531 673 5879 581 572 6657 2002 596 5594 PMC5913620__F2 Regulation of Beta-cell autophagy 5897 5896 23411 9474 10533 8408 9706 3458 3553 468 83939 PMC5913738__F3 Intermittent metabolic switching, neuroplasticity and brain health 2247 627 23410 23411 2475 PMC5915042__F1 Scheme describing the mechanism of lethal autophagy induced by DDA 7376 10682 3164 7942 PMC5915168__F1 MIF signaling pathway and its role in tumorigenesis 4282 960 972 6714 PMC5916970__F1 NFKB/Rel and MAPK pathways activation 8717 7186 7185 7187 6774 PMC5919979__F5 Proliferation-associated lncRNAs act as MYC regulators or effectors by activating or inhibiting the MYC signaling pathway 102723099 100507056 10642 4609 1499 100270680 5820 283120 2475 PMC5922346__F6 Tumor cell death after electrotransfer of plasmid DNA is associated with cytosolic DNA sensor upregulation 55601 29110 3661 197259 7297 PMC5927619__F2 Pathway diagram for IL-2 family signaling showing the increase in detail level as zoom level increases 6714 58480 4145 6850 PMC5927707__F2 Involvement of ZMYND8 and demethylases in the DDR and cancer 5927 23613 8242 54815 4199 PMC5932347__F1 RIG-I-like receptors and toll-like receptor (TLR) 3 signaling pathway 57506 10010 3661 3665 7189 7187 29110 PMC5932548__F3 Signalling pathways initiated by miRNAs and TGFB in diabetic nephropathy 5058 1278 5728 PMC5934344__F1 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy 2932 324 23002 1499 387 6093 PMC5935233__F3 Oncogene-induced genomic instability 675 672 79728 10111 7486 641 9401 100188773 PMC5935908__F8 NRP-1/TNC/Integrin B3/FAK/Akt/NFKB schematic signaling pathway 3690 8829 9429 999 2932 3371 PMC5938062__F6 TAK-733 under an Ang II-induced signaling pathway in vascular remodeling 595 3383 7412 PMC5940532__F2 Signal-transduction events in necroptosis 5495 197259 3458 192111 7098 PMC5940789__F6 MiRNA-gene-pathway network between sixteen intersection genes, and their corresponding pathways and differentially expressed miRNAs 1545 3284 839 840 100423038 9568 4313 6502 4087 4999 4638 5565 PMC5954027__F1 Selective and non-selective autophagy in CD4 T cells upon T cell receptor (TCR) activation 920 2475 5289 9776 8408 60673 83734 PMC5955615__F1 Inhibition of the dysregulated NF-kB/YY1/Snail loop 7528 999 1000 PMC5957449__F3 Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage 23764 196 4780 1544 2944 10257 2938 2939 4363 2947 2948 2949 5447 PMC5959262__F8 The protective mechanism of curcumin by the UPR-Nrf2 pathway after DAI 9817 1998 2932 581 468 PMC5962651__F2 Schematic presentation of autophagy pathway and core autophagy-related proteins targeted by various miRNAs 10533 9140 9474 83734 7405 55626 22863 3920 64422 8417 9341 26100 55062 8408 9706 PMC5963742__F5 BPA increases downstream survival proteins and GPER while attenuating the growth inhibitory effects of EGFR inhibition 4827 6647 2597 1956 PMC5964648__F3 UPRmt and stem cell regulation 23411 468 11331 PMC5964982__F2 Notch signaling pathway 102 5045 100188776 5159 4854 406935 406937 1264 3516 182 4851 4853 7048 7046 PMC5966770__F2 Biosynthesis and consumption of NAD+ 23475 4860 54981 27231 10135 PMC5967272__F1 Aberrant signaling in systemic lupus erythematosus (SLE) T cells 920 960 3932 5728 6426 6774 3662 6850 PMC5968197__F9 MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes 983 10776 2029 4661 7465 PMC5971008__F6 Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma 4004 1362 3987 6251 6019 3611 PMC5974030__F7 Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice 6469 63973 5080 23462 2735 23493 4762 2670 6657 1641 5727 PMC5974170__F3 Lipid droplets and the immune response during protozoan infection 3466 79664 2638 345611 PMC5976231__F5 Vascular wall resident Sca-1+ progenitor cell migration in response to chemokines and lipoproteins 2919 3579 6347 729230 998 5879 6774 4318 PMC5977110__F1 Hippo pathway core components and their upstream regulators 4018 4485 6010 9113 26524 1499 PMC5979464__F3 Beta2-adrenergic receptor signal transduction 367 6011 156 2869 2870 7054 PMC5979540__F6 Hippo signalling pathway identified as the most regulated by detected differentially expressed miRNAs depends on muscle mass 84962 154796 1742 5266 122786 374 174 7048 652 85407 4609 7483 1856 324 23513 4811 2932 7534 PMC5980750__F1 Hippo-Yap signaling in ocular development and disease 4485 9113 10207 154796 861 860 PMC5981260__F2 Tumor suppressor molecules signaling 5728 4193 2932 545 472 672 4094 PMC5982750__F4 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand 1066 8824 7361 5243 324 PMC5983188__F1 Cytokine/long noncoding RNA (lncRNA) interplay in controlling immune cell development and function 7124 684 6352 3576 100506668 102659353 5743 641373 106128901 6023 283120 7503 PMC5985159__F1 Acquired Resistance to Drugs Targeting Tyrosine Kinases 1950 3082 3479 3481 3480 2885 5728 3667 2475 842 7249 7248 6009 64798 PMC5985418__F1 Fibroblast growth factor-23 (FGF23) pathways 8074 1638 1594 6446 9368 65266 2260 2261 56302 PMC5986855__F3 Downregulation of VRK1 by DRAM1 in the autophagic pathway induced by p53 and deactivation of p53 by phosphatases and ubiquitin ligases the proteasome in DNA damage response 472 55332 7443 4193 1846 PMC5993212__F7 Commonalities in epileptogenic processes from different acute brain insults. Does it translate? 627 3146 4615 7248 7249 3654 51135 5335 2475 7189 PMC5993623__F2 Recycling endosome and bacterial pathogens 960 25924 7099 PMC5994257__F11 Schema of signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production 7099 3553 3554 114548 PMC5994595__F3 Excitatory toxicity model of methamphetamine 22926 468 26471 PMC5997132__F4 Main pathway targeted using siRNA delivery systems in oral cancer.Notes: Examples of siRNA therapeutics alter multiple hallmarks applied for oral cancer 3037 1508 55691 7852 57650 6659 51129 961 9531 PMC5997144__F2 P-Rex1 acts as a convergence point for pro-oncogenic/metastatic pathways 3273 7852 57580 3091 PMC5997167__F5 Networks involved in the analyses involving males with nPFOS exposure 85417 9459 914 22866 5412 60385 57471 257415 26281 6872 27086 2596 9399 23151 6046 9185 5925 80018 PMC5997832__F2 IRE1A regulates the immune function through various mechanisms including both its kinase (A) and RNase (B) functions 7097 7099 51284 7186 8737 10392 8767 6892 57506 10628 114548 3603 3569 3600 3606 2932 PMC5998384__F3 Metabolic PathwaysCell-cycle effect on the stability of protein components of the pentose phosphate pathway (PPP) 6888 7086 95 PMC5998602__F10 The schematic illustrates a model of Long noncoding RNA HULC promotes liver cancer cell growth by inhibition of PTEN via autophagy cooperation to miR15a 728655 406948 64422 5728 3265 23411 PMC6001373__F12 Working model for the actions of HDAC1/2 in the regulation of nephrogenesis 3065 3066 130497 7490 6299 10736 5076 3975 6927 PMC6003041__F4 Interaction between oncogenic signaling and lipid desaturation in CSCs 1950 3845 983 47 2194 2261 1956 PMC6003401__F6 Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming 7098 7099 7189 114609 4615 7187 PMC6004768__F1 Defective identified pathways in immunodeficiencies predisposing to high susceptility to Epstein–Barr virus (EBV)-driven B-cell lymphoproliferative diseases 11151 114836 962 3702 970 939 10125 1503 84061 100507436 PMC6005571__F10 Neurogenesis and mediators of neuroendocrine stress responses 1770 10135 814 10085 5270 10664 5885 2561 4914 9607 5179 2554 1958 4760 5074 1020 222008 1600 7442 51100 10983 8941 PMC6014302__F4 GO enrichment of the highest score sub-modules 23478 6745 8666 6208 2107 6193 10952 6175 6233 51121 6188 6155 6133 9086 6210 6223 1915 6166 55173 4809 6203 65003 PMC6015598__F2 Dysfunctional cellular mechanisms in PD 23317 9829 6622 2580 10533 5861 23400 7942 55737 120892 PMC6018527__F1 Sema4D/Plexin-B1 signaling 10507 2064 6237 27289 5879 5335 3984 387 6093 9475 2932 PMC6019481__F9 Regulation of the synaptic vesicle cycle pathway by SE in OVX with (CES)/without (COS) E2-replacement with respect to their non-SE counterparts (CEN and CON) 6844 161 6857 1175 23025 6804 10815 4905 6616 5864 6812 8775 22999 1759 57084 57030 1173 773 774 PMC6019481__F10 Estrogen signaling pathway 2099 3320 2288 2852 4313 6714 2778 1839 3725 6667 2353 1385 108 5566 468 3265 5594 5603 2885 6464 5604 1956 6654 5894 3845 5290 207 5295 810 2770 2775 2550 4988 5580 3708 2776 23236 2911 801 4846 3760 PMC6023743__F1 A well-studied example of modulation of phospholipid signal transduction cascade in the nucleus is turnover of inositol phospholipids, especially phosphatidylinositol-4,5-bisphosphate (PIP2) 5091 23236 5335 5338 5337 4018 PMC6024750__F3 Outline of the three main pathways of colon carcinogenesis 3845 324 4436 2956 5378 4292 673 4255 PMC6027159__F12 TCR signaling pathway 940 81858 9099 10454 7189 23118 257397 8915 PMC6027159__F13 Genotoxic stress signaling pathway 7189 8737 331 472 10454 23118 257397 81858 PMC6028640__F1 Schematic overview of the pathway linking IMMP2L to senescence 83943 6318 2820 PMC6032173__F3 Regulatory mechanisms of selected modifications in PPARG 1796 1020 23411 5495 1022 1025 8864 9967 63976 PMC6032286__F1 Neuromuscular junction and congenital myasthenic syndromes 1103 9581 127833 6843 8292 43 4038 1305 4593 285489 1798 2673 199857 85365 PMC6032434__F6 Summary and model for the potential function of the chIL-34 signaling pathway 3717 10454 8651 6774 6772 PMC6033950__F6 EE2 and LNG affected the phosphorylation of proteins involved in brain development, synaptic plasticity, neurogenesis, synaptic transmission, and calcium ion homeostasis although the specific phosphorylation profiles varied 25942 19 7249 1786 57492 23013 10636 10409 7157 7857 54806 1387 4288 5933 5743 1464 4644 11336 9869 4297 288 324 6334 706 84898 4208 4137 3925 22999 6261 7431 1808 51804 2906 157570 4155 7442 4130 9381 7273 10675 57549 2023 7784 5310 729330 287 774 PMC6038710__F3 Hypothetical model for the role of lncRNAs in rheumatoid diseases 283131 115004 3661 378938 6775 59067 6774 3466 367 4283 836 842 727 1469 406991 3627 PMC6039250__F2 NRF2 and the hallmarks of cancer 8452 9978 2931 8454 9817 6500 2932 PMC6041131__F5 Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors 2867 6422 27122 8651 PMC6041767__F2 Example module (L1) more densely connected in ER- group with red nodes indicate genes belonging to the immune response pathway 1805 716 5348 10261 60468 5699 7462 9353 8404 3108 2212 9770 969 9046 10516 7431 55273 9308 9452 301 240 2669 8631 6422 5777 80833 10252 23179 90865 7409 916 10462 5627 64092 3683 3075 10563 PMC6042636__F2 Sox2: regulation of expression and contribution to brain tumors 6469 10716 6608 51684 5728 324 4089 1499 4087 4088 6657 79923 PMC6045671__F1 Hippo pathway 122786 6788 6789 60485 4771 25937 10413 26524 9113 5784 9686 PMC6046065__F1 Pharmacological modulation of mitochondrial calcium homeostasis 10367 221154 55013 90550 1738 4827 PMC6046302__F1 MAPK and PI3K/AKT/mTOR pathway interactions in melanocytic tumors 2767 2776 5728 5163 673 PMC6047270__F1 Cell cycle arrest induced fibrosis 1021 1019 545 472 7040 1017 PMC6048758__F4 Regulation of SREBP1 and lipid metabolism by oncogenic signaling 1950 3845 983 47 2194 2261 1956 PMC6054450__F3 Merkel cell carcinoma 5925 7157 4851 4853 4297 58508 8085 171023 8289 6597 57492 472 4436 675 54880 672 2475 4163 PMC6057036__F7 RASAL2-mediated hippo signaling pathway 9113 26524 10413 9462 595 PMC6058053__F3 Altered B cell receptor (BCR) and co-receptor signaling promotes increased autoreactivity within the naive B cell repertoire 613 4280 958 26191 7454 PMC6059364__F2 Crosstalk of Notch with p53 and p63 in cancer growth control 4616 4193 7157 572 9314 604 5728 9997 PMC6059371__F1 Function of Hsp70 in suppressing apoptosis after ischemic stroke 581 8772 842 841 836 PMC6059739__F3 Regulation of the Wnt pathway via YAP/TAZ 1856 1499 6925 PMC6059757__F15 PPI networks for key KEGG pathways 7482 3683 3133 23705 89780 22854 3399 947 2263 6693 1003 51208 659 2264 4093 6614 83700 83692 23533 6926 3977 9127 554 2690 7068 3952 1137 10319 5734 115727 117 1128 9002 1135 5155 1441 10316 862 1285 2894 23604 6387 6258 2034 1030 115 PMC6060714__F6 Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway 672 675 5888 5893 PMC6061679__F1 Parkinson’s disease genes reveal an association of multiple variants that converge on deficiencies in cellular clearance 55737 54832 116442 2580 2629 2581 6609 427 1508 84286 1509 120892 4864 23400 535 27074 65018 56922 26503 84148 10229 211 PMC6066750__F7 Role of Slfn2 in type I IFN signaling 7297 3716 108348016 3455 3454 10278 PMC6068284__F3 Fumarase functions in the human and yeast DNA damage response (DDR) to double-strand breaks (DSBs) 2271 9156 84678 6419 PMC6070710__F10 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response 699 8243 375 9184 2033 9700 4193 545 5591 2932 472 4088 10744 4089 6502 9232 7529 7531 324 7533 5111 7534 9134 8900 891 890 894 9133 902 5347 990 8318 4171 4172 254394 4175 4173 55388 3065 4999 23594 1875 1876 1869 3066 1870 1871 8841 51564 5933 140739 7040 701 991 983 4174 PMC6070710__F11 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response 355 356 7124 8837 3002 8718 8795 8772 8738 7185 329 7186 7187 149428 317 572 8739 1147 598 835 596 5602 56616 54205 4793 4794 4790 5970 5366 4609 3725 637 4214 4792 4193 666 PMC6071487__F3 Arid5a stabilizes interleukin 6 (IL-6) and Stat3 messenger RNAs (mRNAs) 7099 4615 10865 5697 6774 PMC6071520__F5 MiRnome circulating in plasma after injury is predicted to be controlled by miRNA processing enzymes and to affect different signalling pathways 4133 5604 4087 4088 1000 3672 894 1022 23405 29102 1870 54487 PMC6073120__F4 Endocytic trafficking of PAR1 9230 6642 57561 11060 8766 PMC6073901__F2 Proposed model for a signaling network between Notch, HIF-1A, and GPER in cancer epithelial-mesenchymal-transition (EMT) 4851 4015 999 PMC6076394__F7 Network obtained from genes sharing different pathways 5781 2215 3937 9846 940 3398 4772 1875 7124 29984 5532 2534 1072 7043 9353 2535 1398 1950 1438 87 10297 5170 PMC6078990__F1 YAP regulates innate antiviral immunity via a transcription-independent mechanism 4485 115004 57506 9113 26524 3661 7003 8463 7004 7005 29110 PMC6080105__F1 Short and Long Noncoding RNAs Regulate the Epigenetic Status of Cells 999 2146 26523 661 4854 27254 PMC6080523__F4 Graphic scheme of pathways shared by genes found in network analysis for progressive motility 5321 27306 5228 PMC6081565__F1 Two classic pathways of necroptosis 7124 197259 8717 PMC6082822__F1 Autoimmune Responses in Severe Asthma 8288 4353 6361 3603 324 8178 6366 PMC6083633__F2 Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC 382 999 1839 1950 1956 120892 640 3481 10457 PMC6085908__F1 Synaptic signaling pathways associated with autism spectrum disorder (ASD) 627 775 9456 8831 23237 4763 7337 5728 2932 7248 7249 6009 2475 1977 PMC6087706__F2 Signaling cascades for YAP/TAZ regulation 60485 999 4485 1499 55233 92597 9113 26524 6714 8994 7003 8463 7004 7005 PMC6088103__F4 AD genes selected by cross metrics analysis and their relation with other diseases 6347 5663 6647 351 7099 627 7040 4803 7422 7157 2932 3569 177 5743 PMC6088189__F1 Tetraspanin roles during HIV-1 infection 975 7102 967 7852 928 102 920 25939 PMC6089764__F3 Interaction network of paeonol and known gastric cancer genes 8797 55359 5222 1634 1829 843 5166 1015 3937 999 2064 3558 7048 836 3576 4804 3605 3553 7248 841 3383 4074 6530 5743 7412 1080 7132 2101 65078 4050 PMC6089967__F2 Gene network of the susceptibility pathways/GO terms 1910 1143 55515 148 10369 1144 2492 773 2895 6326 3761 5340 2550 6262 7442 100653373 6327 1136 3704 783 9992 5617 1080 PMC6090437__F7 Kyoto Encyclopedia of Genes and Genomes pathway analysis of the hub gene secreted LY6/PLAUR domain and its connected genes 23594 132660 5885 1509 637 699 1434 1026 1647 10142 1022 10657 PMC6092430__F1 The mismatch repair pathway 4437 4436 2956 5111 4292 5395 PMC6093783__F31 The biosynthetic pathway of polyoxin 292 5429 27343 11201 51426 5426 5428 27434 5423 PMC6094638__F1 Function and regulation of tumor necrosis factor receptor-associated factor (TRAF)6 in MyD88 signaling pathway 4615 1540 7189 56957 7375 10454 23118 257397 10868 114803 PMC6095600__F3 Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes 7124 5925 6670 3458 3606 6774 5465 7076 972 4094 5698 3430 51129 22937 1717 79071 2180 4597 6721 PMC6096407__F3 LncRNAs activate (e.g 407040 6932 729177 11331 1499 1788 3065 22943 PMC6097257__F7 Merged network analysis from Ingenuity Pathway Analysis (IPA) software for associations among molecules related to rheumatoid arthritis, inflammation of joint, cell cycle and apoptosis 10383 140766 5730 7280 4616 5743 5740 170689 6781 3484 2670 6382 79689 8483 8309 5734 9536 5468 6473 55790 958 397 9232 811 408 5806 639 51053 348 6387 51085 10659 2074 7099 8013 154 91607 4288 4052 2069 221150 6790 4773 890 1356 1839 51203 9099 699 11130 22974 11065 929 1301 4148 152 627 6372 2619 PMC6097464__F7 TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set 1875 25805 3624 9241 8454 4052 4088 57154 90 4092 399 659 7124 64750 7057 10468 7042 7054 759 PMC6098163__F6 Crosstalk between RAAS and FGF-23 pathways 8074 2260 59272 1636 6497 7225 6908 PMC6100584__F2 Crosstalk of the Hedgehog pathway with other protumorigenic pathways 3481 3280 6608 596 1950 1499 2475 79923 6657 PMC6101557__F1 Inflammatory caspases (caspase-1 and caspase-4/5/11) are activated through canonical or non-canonical inflammasomes, triggered by microorganism infection 9447 3553 3606 367 PMC6102867__F2 Regulation network of circRNAs in cancer 367 2146 898 1956 83737 1499 1017 2309 998 7422 114793 693143 1875 1021 6774 3716 9113 330 PMC6103720__F4 Autophagy contributes to integrin recycling and degradation 2335 5747 6714 7314 8408 57533 57111 PMC6104680__F6 Mechanisms of interaction between IL-6 and TGFB leading to fibrosis in SSc 3569 3570 3717 6774 3716 7297 6714 PMC6109047__F7 Pictorial Abstract 4318 7077 4313 999 1499 1856 595 2932 79923 6657 PMC6109711__F3 cAMP/PKA network 269 56666 6623 5778 3248 5499 3146 6597 1020 5514 1390 2033 28996 3172 1499 4286 6496 7417 9934 6660 PMC6109778__F3 Simplified ketone body metabolic pathway 3158 3155 38 84532 35 622 80221 1892 3033 PMC6111708__F2 Hippo-YAP signaling and the pathogenesis of gastric cancer 3248 5803 131 5967 5067 115111 7366 218 1559 2938 1562 496 5222 643834 643847 140690 495 81792 6751 1301 6750 1300 7058 4057 6424 6947 84624 7070 633 7031 2191 7060 4237 54829 23213 7032 200504 5005 56287 10753 5004 166824 57016 1277 PMC6115613__F4 In some cases, migration and invasion are stimulated through NGF or proNGF upon activation of p75NTR and TrkA 4803 4313 4318 57498 1499 6714 387 7291 3725 51176 6925 PMC6115946__F8 miRNA regulatory pathway in the control of the protein synthesis through SIRT1—TSC:mTOR 3479 3480 7248 23411 7249 6009 2475 PMC6116402__F2 Highly connected networks built using reperfusion-upregulated mRNAs coding for proteins known to interact with human proteins 2321 1316 9021 3726 7538 3303 2353 23645 3725 9451 467 5329 3690 2624 1649 PMC6119098__F2 Regulation of the Hippo signaling pathway 999 4771 64398 1499 84962 6714 4485 374 10207 92359 PMC6121269__F2 Pathogenicity and factors associated with the disruption of the normal cellular activity 7157 999 387 1499 324 PMC6121276__F2 Catabolic and pro-inflammatory signaling in osteoarthritis 1490 2247 2260 4322 4313 4318 4087 4090 4086 4089 1280 176 4312 3553 PMC6122069__F1 Two major signaling axes in IGF-1-mediated EMTs in human breast, lung, and gastric cancers 3479 3480 7104 780 6714 302 868 3667 51072 2885 10581 1499 6774 7291 6935 9839 4582 PMC6122270__F3 CD44/CD44v6 and CIC apoptosis resistance 355 11140 836 440514 3082 27040 1839 4316 4318 2885 2549 5091 79923 331 27250 2066 PMC6122736__F7 Mechanism of XWL-1-48 inhibits growth of breast cancer cells 4193 581 472 3014 PMC6126184__F6 Pathway diagram presenting chaetominine mode of action associated with cell cycle regulation in SW1116 and K562 cells 545 472 993 1017 1019 PMC6127659__F1 Long non-coding RNAs affect epithelial-mesenchymal transition in gastric cancer cells 100124700 641638 8726 23512 2146 441951 7503 407040 6935 4087 999 221883 3082 4318 140828 378938 5976 1499 100642175 10413 728655 652995 11091 2932 PMC6129528__F6 Overview of KDM2B mediated molecular mechanisms in cancer development 4609 84678 100187761 5927 51617 PMC6130320__F4 MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics 4282 972 960 PMC6136097__F1 Current putative prognostic biomarkers in glioblastoma 5728 4255 3417 3418 PMC6136992__F2 Sending mixed signals: Cilia-dependent signaling during development and disease 6469 56623 51684 23432 6608 132884 PMC6139039__F1 Stabilizing and destabilizing signals for Tregs 3458 7908 50943 1493 64218 8829 5728 PMC6142582__F2 Targetable molecular features of primary mediastinal large B-cell lymphoma and mediastinal gray zone lymphoma 7124 8651 5770 5966 930 PMC6148305__F12 Hypothetical pathway of MIF-2/D-DT-dependent mechanisms in proximal tubule cell regeneration 972 960 83939 6590 468 595 PMC6149912__F1 Inhibition of DDR1-BCR signaling by nilotinib 780 613 1499 3725 4609 960 595 8549 2353 PMC6152442__F1 SRSF1 regulates SUMO conjugation to different spliceosomal proteins 6626 6625 6627 6629 9879 1665 23020 10594 9128 9129 26121 23451 7307 9343 23450 10262 11338 22827 24148 9416 84991 10421 9410 23350 10523 84844 51639 10291 8175 10946 6426 6608 PMC6154840__F1 PKCι drives both common and lineage-specific oncogenic pathways in lung cancer 3845 6469 6608 5727 55733 6657 51684 1999 1894 5879 5058 2735 4319 100188776 PMC6156430__F2 Schematic diagram of the molecular mechanisms underlying K63‐linked polyubiquitination and cardiac hypertrophy 7186 8717 23118 257397 7189 PMC6160385__F5 Βeta-TRCP in regulating the Wnt signaling 55366 8549 84133 1499 324 100420631 6500 4609 960 51176 6929 4040 4041 PMC6161371__F3 Cooperation between c-Myc and YAP/TAZ or HSF1 cofactor (a) Phosphorilation of YAP/TAZ by Hippo signaling pathway promotes cytoplasmic localization and ubiquitin-mediated degradation 4485 60485 9113 26524 3297 PMC6162743__F2 Overexpressed Prx II regulates stemness-associated properties of HCC cells 6657 4072 57716 595 2305 619501 PMC6162743__F7 Prx II regulates CSC properties of colorectal cancers via PI3K/AKT, Hedgehog and Wnt/Beta-Catenin signaling 57716 6608 2932 1499 324 PMC6163247__F2 Endoplasmic reticulum (ER) and mitochondria interactions 9049 572 596 253782 10715 90550 4397 338340 581 PMC6164133__F1 Intracellular signalling pathways of vitamin A 5950 7276 64220 2171 6714 5914 3717 PMC6165502__F1 The BMPR2 signaling pathway illustrating the potential canonical (green) and noncanonical (grey, blue) targets that can be activated 658 10121 650 659 2280 25932 64750 57154 4090 4086 3397 3398 3399 387 5879 PMC6165581__F2 Illustration of miRNA biogenesis pathway and mode of gene regulation 27161 29102 54487 5901 PMC6166529__F1 Cancer Genome Atlas of glioblastoma multiforme 2064 1956 5156 5728 4763 1031 1019 894 1021 4193 4194 7157 5925 PMC6166714__F7 IRAK4 and MyD88-dependent TLR signaling 4615 51135 3654 7189 3663 23118 257397 PMC6167191__F5 Dendritic Spine Elimination: Molecular Mechanisms and Implications 2043 1020 84466 10461 387 3577 PMC6168336__F6 In this illustration, potential mechanisms of tumor cell survival via crosstalk between components of the MET pathway, glycolysis, and autophagy are depicted 558 3082 2475 64422 PMC6168629__F3 Regulatory mechanisms that control the switch from PKM1 to PKM2 4609 2475 3178 4751 6428 5936 PMC6168666__F3 CARD14/CARMA2 variants in keratinocytes 9706 7186 91614 9616 8915 10892 7189 PMC6168922__F5 Signaling via the ALX/FPR2 receptor 2358 2357 351 PMC6172149__F1 Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity 7018 7035 7124 367 3569 4283 3627 6373 6376 57506 PMC6174864__F8 A working model illustrating HHcy-induced ER oxidative stress and inflammation in endothelial cells 30001 7412 3383 2882 PMC6175639__F8 Schematic Illustrating Potential Pathways for Glucose Utilization and Energy Production by Tendon Cells 1950 6513 3091 4087 4088 5163 3939 PMC6178360__F5 Metastatic adrenocortical carcinoma 367 100187761 472 2040 2066 5916 5949 9611 9612 6595 8648 2033 1387 25 109 115 5610 6774 79923 PMC6180304__F2 Three key innate immune pathways for the most common retinal degenerative diseases 718 3454 3455 7297 3716 10379 6772 6773 8651 9021 706 114132 8205 PMC6188668__F7 Arid5a in the IL-17R signaling pathway 84818 10865 7186 1051 64332 PMC6188698__F1 Regulation of Neurogenesis by DISC1 81565 2932 27185 5142 9638 1499 8313 PMC6189061__F5 Proposed model of irisin effects on pancreatic cancer 595 999 2475 5091 PMC6193900__F1 Signaling pathways and regulatory nodes that indicate novel therapeutic approaches for KRAS mutant NSCLC 2065 2260 10818 7514 9817 64866 7465 3845 6774 6714 29110 56884 10413 1894 5879 3280 5058 PMC6194107__F2 Origins of centromeric breaks 641 7153 5728 55183 1788 1789 5888 23137 545 4437 4438 2956 4436 4439 7150 PMC6199328__F8 TEdeff-induced immunotherapy resistance 1616 8772 3716 3717 841 6772 6774 PMC6201690__F1 Overview scheme of the PD risk factor genes and the molecular pathway where they are involved 683 3128 3117 65018 25793 56922 120892 10229 211 6622 2580 55737 6609 950 84286 1508 535 2581 84148 1509 26503 427 PMC6202076__F0 Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NFKB signaling pathway 54115 5765 1017 207 4609 7157 2033 1387 5970 4790 4792 3551 PMC6203150__F1 Regulation and downstream effects of the Akt signaling pathway 5728 5163 572 7249 7248 2475 PMC6204373__F2 TRAFs in canonical and non-canonical NFKB signaling pathways 5971 7186 7187 7189 7188 7185 PMC6205963__F1 Fibroblast of Growth Factor (FGF) signaling activation and regulation 2255 2248 2256 2249 2253 2252 2257 8822 26291 2247 2251 8817 26281 8074 27006 2259 260431 2268 2885 9846 10818 23677 3280 6469 406952 407035 5640 PMC6206165__F9 Model showing possible mechanism for regulation of ovarian development by four key miRNA/gene pairs 6424 8322 4092 1499 64750 57154 4088 4089 1588 2516 324 PMC6207557__F1 Mechanisms by which rLrp inhibits the production of LPS-induced cytokines 7189 2932 9021 7097 7099 4615 PMC6208163__F6 The Roles of NRF2 in Modulating Cellular Iron Homeostasis 23657 2879 4495 3162 2512 2495 4094 PMC6209965__F3 Natural compounds as anticancer agents in TNBCs: Mode(s) of Action 2475 1499 6608 1956 324 2735 3725 2353 4609 2932 PMC6211389__F2 Schematic view of Toll-like receptor (TLR)-mediated type I interferon (IFN) gene induction by IFN regulatory factors (IRFs) 7099 4615 114609 54106 51284 7098 7187 3654 51135 7189 3665 3659 3663 29110 3661 3394 PMC6212953__F1 Hepatitis C Virus (HCV)-induced oncogenic signaling 1956 9021 6774 4089 4087 4088 324 10847 PMC6214025__F9 Combined nano-therapy strategy of MSN containing DOX and AgNPs in cancerous cell 594857 4478 7498 4846 7153 4436 4292 2068 7157 PMC6214858__F7 Schematic flow diagram of signal transmission from regulatory factors secreted by TM4 cells to ADSCs 1950 7040 4193 79923 6657 1878 8178 PMC6215570__F6 Akt/mTOR pathway and regulatory effects of galangin and pinocembrin on the phosphorylation of key proteins 5728 7249 2475 6194 PMC6215878__F6 Diminished inhibin B (INHBB) expression activates the transforming growth factor‐B (TGF‐B) pathway to promote anoikis resistance and migration 3625 999 4087 4088 4089 PMC6217754__F1 IL-32-induced signaling pathway activation in macrophages 9235 6774 4513 2920 3603 2919 PMC6219034__F10 PRRSV-induced G2/M cell cycle arrest in MARC-145 cells 995 4661 891 7465 PMC6219450__F3 DSB-free recombination-dependent replication.A 4361 9156 1763 5888 5893 675 7486 PMC6220113__F4 Illustration of lipoprotein alterations in chemotherapy recipients after 6 months 4023 7038 335 PMC6226306__F1 New Therapies in Head and Neck Cancer 6774 2475 5163 1956 PMC6230580__F2 Snail and cell-cycle progression 5111 6935 1499 894 999 595 PMC6233178__F1 Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury 83939 22926 468 22809 6098 114548 3553 PMC6246015__F2 Signaling pathways subverted in T-cell oncogenesis 940 29851 3932 27040 2534 5163 3716 2885 7535 56940 84433 8915 6774 5777 10892 7409 387 5879 2475 5970 4609 596 PMC6251060__F1 Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease 7405 8408 9776 64798 60673 55626 596 9140 83734 9474 10533 23192 64422 55014 PMC6252103__F1 Transcriptional regulation of aspartate Beta-hydroxylase (ASPH) 3479 3480 3667 5163 1499 444 PMC6252330__F1 Molecular mechanisms underlying cell cycle by cancer stem-like cells 983 1017 1021 1019 5728 7248 7249 1018 3280 PMC6255979__F2 Non-canonical mechanisms whereby betaine inhibits IL-1B production 64170 10892 114548 8772 3553 PMC6260778__F6 Hypoxia induces differentiation of T-cells to Tregs 2475 4088 4089 50943 PMC6261981__F2 Potential mechanisms involved in propagation of Alpha-syn 7097 2475 4353 3458 114548 7054 26994 PMC6265572__F6 MiRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults 3480 4485 9113 26524 324 2932 1499 PMC6273223__F2 Genistein (0.01–10 μM) stimulates breast cancer cell proliferation acting through the classical genomic ER pathway and/or through the fast, non-genomic GPER1-mediated pathway 1839 1956 2852 427 PMC6275018__F3 Representative model of leptin-induced EMT signaling 3717 207 2885 6774 PMC6276815__F3 Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience 5978 429 4760 23040 4929 3170 5309 54738 2624 4010 3670 8022 1745 1746 2290 6657 1749 26468 7018 3630 238 2932 7054 PMC6278198__F5 Schematic summary of the possible mechanism for GLCCI1 in glucocorticoids pathway 2638 113263 2642 3553 PMC6278419__F5 PPI network and module analysis 197 338 5340 324 259 350 213 2243 7276 3263 PMC6279860__F1 Targeted therapy for recurrent/metastatic head and neck cancers 324 1493 7186 7185 7187 940 7188 7422 7423 7424 7039 1950 1956 6774 2885 6714 7249 7248 6009 2475 5728 PMC6282071__F3 Increased P2X4R expression after nerve injury via the actions of fibronectin in activated microglia 6347 1380 4067 1977 3663 4193 3394 729230 PMC6285187__F8 Illustration of the working mechanisms for FGF21 prevention of spontaneous and diabetes-induced germ cell apoptosis 26291 207 208 2932 23411 4193 PMC6287101__F7 Overview of complement cascade activation and targets of inhibitors 1604 4179 2271 720 718 717 5648 10747 727 966 730 3596 3553 PMC6289335__F1 Molecular actions of CTLA-4 and PD-1 on inhibiting T cell function 2475 5728 27068 940 941 942 PMC6290138__F2 Hypusine–polyamine pathway in human neuroblastoma 4613 4143 196743 6303 6723 1725 6611 54498 83475 PMC6290461__F2 Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases 142 5111 5888 2547 PMC6293111__F6 Model depicting the molecular function of Lsm12 5111 124801 353497 PMC6293255__F5 Top two networks (A and B) identified by Ingenuity Pathway Analysis as overrepresented within the list of 245 genes (P < 0.005) dysregulated in human IAPP transgenic (HIP) vs 4060 5055 10268 2099 2353 5329 79603 5468 6347 8626 467 2550 5270 4862 PMC6294046__F4 Druggable proteome across five classic cancer pathways 3815 1956 238 4893 3265 3845 5290 3417 3418 5728 673 207 2475 2099 367 1950 PMC6294998__F2 New therapeutics based on emerging concepts in pulmonary fibrosis 1956 3586 3596 7039 6347 6387 PMC6295076__F7 Hypothesied pathway showing the inhibitory mechanism of cyclin G2 on Wnt/Beta-catenin signaling through Dpr1 901 324 2932 1499 PMC6295421__F5 Proposed mechanisms of nitrergic neurotransmission in the SIP syncytium 4842 7432 5156 55107 PMC6300493__F4 Inactivation of the Hippo pathway induces breast cancer metastasis 3993 57787 221078 60485 6497 4485 9113 55233 25 10006 27 10152 PMC6301827__F7 Schematic representation of the relationship between Rab1a and the HIF-1a/miR-212-3p/Rab1a regulatory pathway in HCC proliferation and migration 3091 1019 5861 1017 999 PMC6302140__F11 Schematic depicting the proposed molecular mechanism by which citrate regulates cellular redox signaling pathways in BMSCs 6448 51382 51026 103910 10381 5873 6648 8721 5050 51181 1349 PMC6306051__F7 Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway 4869 999 6502 PMC6307204__F5 NFKB signalling pathway is involved in endogenous DcR3 expression in HUVECs stimulated by LPS, LTA and zymosan 4049 7097 7099 4615 51135 3656 7189 PMC6309125__F1 Hippo Pathway and its canonical upstream regulators 2195 83593 2196 120114 79633 83937 9770 11186 166824 24147 122786 84962 55233 60485 92597 4485 7003 8463 7004 7005 PMC6310611__F2 Metabolomics reveals the limitations for the in vivo application of GNF-351 due to poor absorption and high metabolism 196 1576 1543 1565 4827 2147 2152 2153 PMC6311524__F1 The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA 10797 7298 6472 29958 1757 4524 4548 1719 PMC6314075__F2 Nuclear factor of activated T cell (NFAT)c1-centered osteoclastogenic signaling network 10371 80031 126014 10326 8829 7189 8205 6850 7006 100124696 695 100187907 4772 81501 PMC6314240__F2 TGFB signaling as well as the role of TGFB signaling pathway in cancer onset and progression 4092 6010 4087 4088 4089 2475 PMC6316616__F2 HSV-1 deregulates host miRNAs 27250 407010 406921 2926 3659 57584 693234 998 3075 3458 10892 PMC6316701__F1 SUMO cycle 29843 59343 26168 205564 5903 10055 26036 10346 9063 8554 10401 51588 10210 PMC6316710__F1 NCOA4-mediated ferritinophagy pathway is regulated by intracellular iron 8924 8161 2495 8031 PMC6317074__F1 Proposed cholesterol-lowering mechanisms of PS 64241 64240 19 3949 39 29881 PMC6317189__F4 Targets molecules of bta-mir-182 involved in the apoptosis signaling pathway 9448 835 5581 54205 842 6093 596 10018 22808 983 726 PMC6317572__F2 Common downstream targets for cancers of the breast (blue dots), colon (green dots), lung (red dots), and prostate (brown dots) 472 545 4088 4089 1027 1026 1030 1029 2932 993 6502 1021 1019 1017 PMC6317881__F6 Interactions of genes involved in tumor progression and EMT 176 2706 7157 7431 2202 999 64236 2597 7076 4326 4322 54 2526 1522 5111 596 10763 6935 836 1000 PMC6320836__F6 Status of proteins that participate in the autophagy pathway in glioblastoma 8878 1956 8408 1499 3091 7405 9474 84938 PMC6321520__F1 Expression of Insulin/IGF signaling components is modulated by miRNAs 3479 3481 5728 8660 3667 5770 5163 554210 2885 23239 3845 2475 572 PMC6321920__F1 HPV induces, yet tolerates, replication stress (RS) to promote viral replication through the ATR-dependent RS response 23135 6241 1869 5111 7403 1017 PMC6323178__F5 Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway 7099 6714 207 208 29110 3661 PMC6323488__F3 Different signaling pathways related to EGFR activation induced by CTGF/EGFR interaction 1956 5111 27035 983 1017 891 PMC6326689__F3 Molecular pathways modulating lifespan via control of the translation machinery 1998 7248 6009 7249 29904 23367 468 1938 1977 1975 6194 PMC6331329__F5 InterferonG regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells 3066 595 1019 PMC6332791__F9 A proposed model underlying the OTUB2/U2AF2 axis as an activator of the Warburg effect and tumorigenesis in NSCLC cells 78990 11338 5230 2475 PMC6332805__F3 Selective Autophagy degrades cell cycle proteins 983 595 10013 1111 390 5888 10273 7428 1017 PMC6333895__F6 Cell migration elicited by chemotactic GPCRs via the GBG–P-REX1–Rac pathway is mainly mediated by Gi over Gq or G13 because of the tight control that GAq and GA13 subunits exert on GBG 4018 7852 5997 5879 PMC6335102__F8 ANG II induces cardiac hypertrophy by multiple means involving direct actions on cardiac myocytes (cm) or the release of paracrine factors from other cell types, such as endothelial cells and fibroblasts/myofibroblasts 545 6714 6868 1956 50507 140885 387 2475 10135 7220 7223 PMC6335683__F1 Crosstalk between hepatocytes, hepatic nonparenchymal cells, and ncRNA during the pathology of NAFLD 7038 6774 9021 442918 3569 4015 378938 7471 948 PMC6335974__F1 Network displaying key genes involved in apoptosis, DSB repair, Fanconi anemia pathway and homologous recombination 55120 545 836 2177 2073 842 675 2074 472 7157 7158 596 5888 7015 PMC6337248__F1 Intracellular signaling pathways that regulate Nrf2 8452 9817 8454 4094 PMC6340995__F8 SNO profile of inflammation and immune responses network in Chagas disease 7414 301 7408 2934 4353 60 6279 7528 3329 6925 4860 57620 1431 2316 302 7057 1019 2885 2950 3043 PMC6341270__F1 Mechanism of Nrf2 activation and Nrf2-mediated antioxidant responses in the lungs 9817 9978 4094 PMC6343613__F1 Mechanism of IL-22, IL-22receptor as well as IL-22BP and signaling pathway 7297 3716 6772 6774 PMC6346071__F1 Cysteine anabolism and catabolism pathways 2937 875 4357 2805 51380 2806 7263 PMC6346557__F7 1A,25(OH)2D3 attenuates Il-6 and IL-1Beta-mediated inflammatory responses in MacCM-stimulated human white preadipocytes 5970 3603 3569 PMC6348405__F3 ATF4 is activated by the perturbation of mitochondrial function 1352 10533 217 2395 55669 9927 468 83667 26291 PMC6348405__F4 ATF4 regulates the serine synthetic and mitochondrial Folate-mediated 1C metabolism pathway 1491 875 5723 29968 6472 26227 10797 PMC6348405__F5 Growth signal activates ATF4 and mitochondrial metabolism 2932 7249 7248 83939 1977 468 PMC6349383__F3 Summary of the oncogenic pathways genetically disrupted in the UM-SCC oral cavity cell line panel 1956 2064 2260 2261 3480 4851 4055 9817 5728 841 8626 4780 4609 1499 595 1029 1021 5925 1869 2195 7157 PMC6349473__F2 Developmental processes regulate craniofacial variation in disease and evolution 4089 6469 6608 4091 23314 51684 6938 7291 860 PMC6351482__F4 Mutation enrichment of Nectin adhesion pathway 5908 5906 5817 5155 5159 50848 999 1495 1499 5797 9076 5290 23396 7094 3690 3685 5747 6714 7410 1398 9855 5879 2889 8826 998 PMC6352210__F4 Internalization and cellular trafficking of FGFRs 2261 2264 999 2260 2263 5058 6714 PMC6352225__F6 Schematic illustration of the role of human papilloma virus (HPV) oncoproteins in the production of macrophage migration inhibitory factor (MIF) 8205 4282 2475 3939 PMC6353800__F4 Hepatic gluconeogenesis is modulated by histone deacetylases (HDACs) 2642 10013 200186 8841 2308 3172 6095 PMC6353984__F5 Downregulation of G2/mitotic-specific cyclinB1 triggers autophagy via AMPK-ULK1-dependent signal pathway in nasopharyngeal carcinoma cells 891 8408 9776 22863 115201 PMC6355473__F4 New targeted therapies in advanced primary cutaneous anaplastic large cell lymphoma 4851 204 50808 203 914 6774 238 7084 1636 PMC6355689__F3 Pathway representation for dopamine metabolism 7054 217 1644 4128 4129 6571 216 1312 6531 1813 1814 1816 1812 PMC6358904__F4 Graphical model of IL-1B activation of signaling pathways leading to acquisition of resistance to cisplatin in breast cancer cells 3553 1956 1499 8626 472 PMC6359168__F3 Apoptosis induced by Endoplasmic Reticulum (ER) stress 7186 468 596 PMC6361534__F3 Mechanisms through which complement modulates T cell-mediated rejection 324 728 719 718 27202 50943 PMC6364748__F2 Oncogenic and tumor suppressive signaling involving Dmp1 and Arf 1019 595 4609 7291 648 6909 6926 2146 5728 3725 7124 7528 4193 472 PMC6368065__F7 Hematopoietic deletion of COX-2 increases adiposity and AT inflammation in obesity 4513 1857 8312 8322 4321 2167 PMC6371813__F1 Protein synthesis and degradation pathways in skeletal muscle 3667 2308 1977 PMC6374451__F7 Schematic overview of DNA demethylation during glioma progression 898 1019 1029 5295 5290 10643 5266 PMC6374752__F1 Tryptophan-kynurenine pathway and major functional consequences in the context of GBM growth 3620 169355 130013 PMC6375548__F6 Alternative (backdoor) androgen production and masculinization in the human fetus 6715 1583 1646 3283 1586 3284 3293 100187761 6716 PMC6379038__F2 Cholinergic signaling via nAChRs and muscarinic acetylcholine receptors (mAChRs) regulates striatal function 3717 6774 7054 PMC6379985__F9 Schematic diagram shows the mechanism underlying cTFRC as a ceRNA for miR-107 7037 999 2475 1499 PMC6383680__F6 Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 signaling cascades 10392 64127 637 55054 9140 9474 331 7186 7188 7189 23118 257397 10454 85451 PMC6385756__F7 Diagram depicting the prostanoid synthesis pathway and the effects of PGE2 on its receptor subtypes 5743 5742 9536 22949 5226 5228 3248 5733 5732 5731 5734 11251 5737 5739 6915 PMC6386093__F5 Metabolic profiling of intracellular metabolites involved in branched-chain amino acid catabolism 35 727 718 5728 PMC6386897__F4 MiRNA-gene-pathway interactive map 5578 5595 5566 1432 207 5598 10000 2308 3725 208 5728 4303 22800 4893 2309 3845 5290 3265 5881 22808 5562 5880 8399 25780 5293 PMC6387402__F1 Activation of signaling pathways in respiratory epithelial cells upon viral infection 7099 3454 3455 7097 4615 7297 3716 7098 51311 51284 57506 6772 6773 7189 7187 3661 10379 PMC6387609__F7 Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3B/Beta-catenin signal pathway 2932 1499 4286 PMC6387630__F1 Representative pathway featuring multiple enzyme-/non-enzyme-assisted post-translational modifications (PTMs) that control cell-decision making 9817 9978 8452 2534 PMC6388767__F1 Bromouridine sequencing (Bru-seq) of MI-503 treated Ewing sarcoma cells identifies the SSP as a key oncogenic target 26227 29968 5723 6472 10797 PMC6395693__F5 Transcription factor regulatory effect network identified using Ingenuity Pathway Analysis (IPA) 5927 23493 3428 6525 2316 2626 3339 4627 7139 8557 11155 1482 1158 4625 1760 2876 7791 4624 PMC6396666__F3 Protein–protein interaction networks.Notes: Upexpression genes were analyzed and constructed a network 10615 54892 6491 641 4638 5567 1104 9212 7203 56992 11130 991 4174 259266 11065 995 23194 9232 51659 10460 1894 3070 3479 10721 891 2247 8317 27306 5427 2353 4171 10036 6866 PMC6397564__F6 Critical roles of B3GalT5 and the globo-series GSLs in regulating the apoptosis and survival of breast carcinoma cells 10317 1956 960 6761 2524 355 857 8772 1499 836 6483 PMC6397982__F8 HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells 3949 4513 3603 PMC6399501__F2 Mechanisms of pathogenesis of inborn errors of SL metabolism 8879 2629 3074 7357 204219 2531 10558 9517 PMC6400990__F2 Schematic overview of glycine metabolism and six genetic loci for glycine in/near genes encoding enzymes related to glycine metabolism 2731 2653 5723 26227 1373 PMC6401655__F1 Subcellular localization and function of the eukaryotic LSM complexes 57819 25804 27258 51690 11157 27257 23658 51691 PMC6406504__F2 Differentiated insulin-producing cells (IPCs) for transplantation 389692 5078 3651 7018 3240 3082 6469 PMC6406579__F3 Current model of Cln3 function in Dictyostelium 1200 1509 1201 PMC6406801__F6 Kinetochore PP2A-B56 and PP1 promote the stability of microtubule attachments and efficient Spindle Assembly Checkpoint silencing in animal cells 147841 83540 57405 57082 9184 699 5347 983 10403 79003 PMC6412338__F3 mTOR signaling network 5163 64798 7249 2308 2309 2152 7248 6009 6446 29904 5728 8408 PMC6412627__F1 Synthesis of triacylglycerol (TAG) 150763 84803 137964 4018 10554 10555 56894 56895 55326 8694 84649 4245 4247 4248 4099 PMC6413120__F1 The MRN complex and the DNA-damage response 10111 4361 472 142 9656 672 PMC6414158__F4 ceRNA regulatory network associated with the MAPK signaling pathway 23642 284835 1386 5908 5495 PMC6416708__F1 Triglyceride-rich lipoprotein metabolism and mechanism of atherosclerosis 4023 27329 51129 3949 4035 PMC6433978__F2 Complement activation pathways and examples of complement-targeting therapeutics for IgAN 2271 1378 10877 81494 10878 3078 3080 717 720 721 718 727 729 730 966 735 PMC6436660__F3 Bioinformatics and miR-135a-3p gene profiling predicts p38 as a targeted signaling pathway 8904 3992 337972 79050 54939 28952 54932 83878 26086 8638 84292 79843 256586 55739 2232 65095 7593 79724 29926 9374 7775 7727 1939 221785 29925 80221 65982 1723 PMC6437095__F4 Interaction between miRNAs and apoptosis pathway in GC 4803 7124 355 8772 7186 8717 3479 23411 4214 572 2638 4087 PMC6441206__F3 Regulatory network of ferroptosis 23657 9817 8314 3658 5261 55847 8678 54583 4495 1036 3652 7417 7419 2879 4015 PMC6442448__F1 Compound-target network 2891 5139 5970 2932 4843 3356 9536 3643 154 5578 6331 3565 890 3320 150 5467 5733 10499 4313 2155 5294 5743 3569 1803 3586 1956 4048 4846 1129 7124 596 7157 6401 3458 1401 4318 7422 959 4314 9429 6256 5327 2159 6347 7056 5465 4353 2152 PMC6443597__F8 miR-4739/BMP-7/Smad1/5/9 pathway induces pleural fibrosis 655 4087 4088 4089 4086 4090 4093 1277 999 PMC6444804__F2 Hypothalamic Lipids and the Regulation of Energy Homeostasis 1270 355 7351 181 5443 PMC6445045__F1 Schematic representation of the unfolded protein response (UPR) 22926 6667 468 7494 6668 PMC6446698__F1 PI3K signaling pathway: growth factors such as insulin stimulate tyrosine kinase receptors resulting in their autophosphorylation 3643 5163 5728 3667 7248 6009 4193 10628 572 PMC6446705__F2 Pathways modulating NAD+ levels in mammals 203447 4837 93100 952 142 PMC6448148__F1 Biosynthesis of all known wyosine bases 129450 4553 127253 55253 PMC6450419__F4 Watch what you (self-) eat: Autophagic mechanisms that modulate metabolism 26747 8924 8031 5071 65018 10133 8878 PMC6451240__F1 Phagocytic pathway in glial cells 558 945 54209 7099 84466 1378 2829 1524 10890 55737 120892 23208 23400 PMC6451295__F3 Different sources of EVs in the cancer-to-stroma communication network 9965 967 94025 140885 1956 100124700 PMC6452301__F4 Interplay of well-known germline and somatic mutations in atherogenesis 27329 255738 4023 3949 324 116519 3553 6272 PMC6452649__F7 Schematic model depicting RARA’s involvement in regulation of intracellular signaling, protein synthesis, and synaptic plasticity in postsynaptic neurons 5914 7248 7249 6009 PMC6458279__F5 Overview of the ferroptosis pathway and potential targets for pharmacological inhibition 2937 2936 2879 4015 PMC6458768__F1 CD22 structure and signaling pathway 613 933 619537 PMC6459338__F3 Classical and “back-door” pathways of androgen biosynthesis 1583 412 3293 8644 1586 3294 1588 6715 1645 1646 7366 7367 9420 PMC6462321__F7 General summary of the NBP-involved cellular signal pathway in (a) cancer cell proliferation, migration, and apoptosis and in (b) stem cell differentiation 4318 596 581 PMC6463562__F6 Proposed scheme for PAHSA synthesis 2194 47 84830 51390 570 9588 4257 4259 PMC6463794__F6 Summary of the proposed inhibitory mechanisms exhibited by WG-391D in ovarian cancer 7046 1031 1021 1019 1874 6667 994 PMC6464042__F6 mTORC pathway regulation 261726 7248 7249 51451 79726 54468 84219 81929 56898 54541 9817 5170 51699 9559 28956 8546 253260 79109 55737 2475 8649 23557 57617 64601 64223 207 27072 55207 5291 2783 201163 65082 23339 55004 PMC6467501__F1 Xs and Y of immune responses to viral vaccines 6375 3600 9636 1471 3105 960 51284 9447 2537 6714 23321 7706 4939 100 4599 3669 472 10625 11262 3665 58487 PMC6476918__F1 Canonical and alternative Wnt signaling pathways 1499 324 387 5879 9113 26524 51176 22943 1386 3725 PMC6477167__F1 Interplay between HPV-infected keratinocytes and the local immune microenvironment critically influences cervical carcinogenesis.HPV suppresses inflammatory signaling in the host keratinocyte 6364 3553 6347 920 1236 3606 PMC6477797__F6 Biological pathways associated with non-synonymously mutated genes in TCL1 mice 958 1956 613 2152 5465 7187 399 3845 5728 3679 5295 5266 9968 2475 4869 256646 2000 3551 PMC6477904__F1 Blnc1 assembles ribonucleoprotein transcriptional complexes with hnRNPU to form a positive regulatory loop with EBF2 and Zbtb7b 3192 10658 64641 51043 PMC6478619__F1 Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif is a point of convergence in signaling pathways 3479 3845 3667 8660 6010 253260 4485 9113 26524 1956 374 332 6374 PMC6484299__F7 Schematic representation showing that B‐arrestin2 (ARRB2) negatively regulated NOD2 signalling pathway through the association with TRAF6 in cerebral ischaemia/reperfusion injury 409 7189 4318 64127 PMC6487091__F3 Mechanisms involved in the prooncogenic activation of the NRF2/KEAP1 pathway 3845 673 3725 4609 9817 100859927 PMC6487484__F1 Mechanisms Linking Mechanotransduction and Cell Metabolism 387 999 1499 PMC6487484__F2 Mechanisms Linking Mechanotransduction and Cell Metabolism 1499 387 999 PMC6491460__F2 Modes of MUC1 control of cellular inflammatory signaling pathways 4582 7099 4615 7098 51284 57506 114548 PMC6491463__F3 Schematic depiction of the CD38/CD203a/CD73 adenosinergic pathway as a major mechanism of the acquired resistance to anti-PD-1/PD-L1 blockade within the BM niche 100187907 952 5914 PMC6491942__F10 Schematic depicting the sensitization mechanism of CsA to crizotinib 6774 283455 54106 4772 695 PMC6492276__F2 Biosynthesis of O-GlcNAc and UDP-GlcNAc 2821 2673 64841 6675 8473 10724 PMC6492362__F7 Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition via the Hippo signaling pathway in human bladder cancer 4485 60485 9113 26524 822 PMC6496459__F3 Differential regulation and effects of glycolysis induction in GM-DCs upon stimulation over time 958 941 942 355 1236 2475 3091 PMC6496801__F1 Caspase‐1–dependent and independent pyroptotic pathway 79792 140609 9447 114548 6010 PMC6497965__F6 Proposed signaling cascade for phosphorylated PCNA-promoted EMT 5111 472 2932 PMC6498051__F7 IFNG pathway associated with differentially expressed genes between SRHIC and WRHIC purified CD8 T cells 204 7297 3716 8651 10379 581 3659 3458 PMC6499473__F1 A Developing Therapeutic Decision Tree for Ductal Breast Cancer with Emphasis on the TNBC Subtype 1029 5266 1019 1021 PMC6500875__F3 Mechanisms of Annexin A1 in tumorigenesis 999 4089 4087 4088 PMC6500972__F8 Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents 142 29117 81847 PMC6504273__F1 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway network for Kashin-Beck disease (KBD)-related genes 2243 5624 2162 5328 2149 5265 2160 2244 735 4153 3949 2161 629 1675 196883 3075 3674 10747 6262 5340 7143 3688 3908 7171 3690 3655 581 3107 8740 317 1075 2158 5321 8605 115 2157 717 PMC6506819__F3 Disease-Associated Genetic Variation in Human Mitochondrial Protein Import 4716 10730 183 115209 PMC6507272__F3 Role and expression of proteins identified by proteomic analysis within NAD+ metabolism and signaling pathway 952 65220 10135 133686 23530 54981 27231 23057 349565 4837 4860 83666 83594 93100 554235 22978 PMC6509151__F4 The role of FcμR in central deletion and B cell repertoire selection 9214 4280 2308 5896 3512 PMC6511648__F1 LSD1–NOTCH–ASCL1 Axis in Small Cell Lung Cancer (SCLC) 429 4851 3280 5978 PMC6520733__F6 Proposed model for ANXA2 regulation of AKT activation 1950 1956 5728 302 7001 PMC6520855__F1 Hedgehog pathway in absence (a) and in presence (b) of HH ligand 374654 6608 156 51684 25989 2737 2736 2932 8445 5347 1859 PMC6521797__F2 Siglec-7 mediated inhibition of NK cell cytotoxicity towards tumor cells 6714 6850 4277 100507436 PMC6522820__F1 The PI3K/AKT signaling pathway 1950 5163 5728 PMC6522855__F2 Complement pathway 716 717 720 721 1604 4179 1380 966 PMC6522898__F10 Schematic illustrating the mechanism in which elevated HP induces apoptosis in RGCs through the regulation of the NGF signalling pathway 3240 4803 2308 PMC6522942__F3 Polyphenols modulating upstream (TLR activation) and downstream (different kinase and transcription factors) pathway of surface and endogenous TLR to reduce or demolish pro-inflammatory cytokines and type I interferon generation 4615 114609 51135 7189 PMC6523349__F3 YAP regulation in early stages of prostate cancer 122786 4771 9113 4485 2115 2078 PMC6523349__F4 Hippo pathway regulation of advanced prostate cancer 387 367 5728 4089 2146 2119 2118 2115 26524 4485 PMC6523349__F5 YAP/TAZ regulate prostate cancer stem cells (PCSCs) 8654 26524 4485 367 9113 6657 79923 PMC6523616__F8 A transcriptional and post-transcriptional regulatory system mediating the hepatic metabolic switch in chickens 2309 407040 9448 768216 574032 3066 6720 84706 2194 6307 PMC6527025__F1 The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections 57506 3661 9140 9474 PMC6527583__F4 Acute phase response network: The acute phase response was the most-significantly represented pathway common to all CAPN5-NIV stages 716 721 715 720 727 3572 3263 735 2244 64423 259 2266 350 5004 5950 2335 2243 335 7276 3273 7018 2147 PMC6528874__F1 Anti‐tumour effect of TNFA and IFNG alone and in combination 100187761 3458 355 6950 PMC6528901__F4 Implications of 15‐LOX‐1 in angiogenesis in different models 3383 961 1386 PMC6530577__F3 Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis 468 3667 1066 27329 PMC6532024__F3 Inflammatory loops in the EIME of psoriasis 79092 7189 8915 10892 11009 2920 2919 6364 6288 PMC6532024__F6 Regulatory mechanisms of the IL-17–TRAF6 pathway 79092 7186 7188 8915 10892 29110 1540 7189 29761 9618 23118 257397 10454 7187 57162 10682 PMC6534064__F1 Drugs targeting Wnt/beta-catenin signaling in Desmoid-Type Fibromatosis 324 1499 8038 6664 4040 4041 PMC6534496__F6 Outline of the main altered pathways in SiNETs 1026 7157 1027 7345 4595 1956 6405 4968 340419 7855 4040 4038 4041 6714 4255 5728 1616 5605 4292 2956 324 253430 5395 4436 4437 4438 7249 7248 2475 1499 4089 7428 PMC6534778__F2 TLR4 signalling in hypertension and potential therapeutic targets 7099 3654 51135 3656 4615 7189 23118 257397 7187 29110 3661 3553 PMC6535783__F1 RNF8 involves in DSB signaling pathway 3014 472 1108 9025 9656 8445 83746 221037 165918 5888 79728 10537 PMC6538222__F3 The Keap1-Nrf2-ARE pathway 9978 8452 4094 9817 PMC6538889__F1 Switch-on and switch-off of canonical and noncanonical Wnt signal pathway 4040 4041 324 1499 5879 3725 PMC6538920__F1 Wnt signaling pathways 1499 2932 324 3725 1356 4040 4041 PMC6539048__F5 Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study 3398 9124 7320 4214 51129 9451 10628 3397 4323 3549 7415 1958 3308 4089 7422 3490 10468 1889 1909 367 7049 2099 894 4170 1959 7071 2353 3643 55023 5337 871 6870 7832 91851 PMC6539482__F1 The core components of the mammalian Hippo signalling pathway 4485 60485 9113 26524 PMC6540047__F6 BRO priming of NFkB target gene expression in the absence of virus 3976 1437 6347 10135 3627 51752 2920 6351 3600 650 7124 3569 8743 715 4283 3456 6385 3105 7097 3601 3383 958 969 7412 4843 2634 91543 4792 5698 6890 6891 3659 1616 3665 22797 64332 1958 6352 7128 PMC6540157__F1 RNA granules and caprin-1-associated tumorigenesis 83939 961 4609 167227 4076 27161 PMC6541695__F2 IGF-2 bioactivity at the surface of an ovarian granulosa cell 3481 6781 3485 3643 3482 3667 PMC6543669__F2 LncRNA/pseudogene–miRNA–mRNA ceRNA network in CRC 10090 1902 6844 79739 79980 5308 6894 7145 10085 4638 3084 4211 79027 2263 8556 100505881 57188 324 389114 9750 23642 5099 55885 693122 51050 9770 91526 8470 9915 10439 5341 284406 9510 114876 23492 55131 699 10468 4684 128272 10984 25937 6804 158222 1612 115207 6636 3070 145864 64699 80728 654434 256236 63924 6322 389849 285958 55022 79017 1734 51092 56603 962 596 8613 10058 6666 2247 10000 6623 10444 407975 283120 2260 154661 113157 79987 132864 8061 9456 1435 2252 116988 7782 8406 51435 23111 55084 54941 154810 2774 79586 6781 2050 391634 90139 23250 57520 6935 23314 84918 1809 54796 56937 57198 9423 3897 9783 284252 PMC6545921__F5 Type I IFN plays an integral role in macrophage regulation of Mmp28 following stimulation with PAMP 929 79148 6351 3627 3716 114609 7297 6772 6773 3665 7098 7099 4615 PMC6547527__F8 a The Spearman correlation coefficient revealed the association between the changes of fermentation parameters and the expression of these eight growth-related genes (SCC > 0.85 and p < 0.01) 6591 5594 5291 60485 572 3655 8743 1739 PMC6547757__F10 Impact of flight condition on expression of crystallins in the network of proteins associated with ophthalmic disease as defined by Ingenuity Pathway Analysis (IPA, https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis) 11334 55544 1977 6300 64795 5036 11102 7157 2033 84295 816 7343 10923 1410 6015 4094 4152 84365 5437 5073 1411 1413 PMC6547810__F8 Schematic drawing of the suggested intracellular signaling pathways of LIF and OSM receptors in osteoblasts mediating expression of osteoclastogenic factors, osteoclast formation and bone resorption 3977 9180 3976 5008 3716 3717 6774 6464 2885 PMC6548160__F3 CSC signaling pathways which are regulated by BRCA proteins 2735 50846 4851 672 6469 3549 182 3717 3716 PMC6548416__F2 Impact of diet-derived signaling molecules on human cognition 1950 2475 7157 3265 572 3725 112476 5894 5604 PMC6549028__F1 Emerging roles of inflammasome‐dependent cytokines in cancer development 6010 9447 8161 3553 3146 PMC6549073__F9 Cisplatin-induced apoptosis in p53-intact and p53-disrupted signaling pathway conditions 545 7465 983 PMC6554677__F1 A model for the regulation of T cell-mediated adaptive immune responses to apoptotic cells 940 942 941 324 100187761 PMC6556902__F2 Analysis of severe asthma differential expression gene signature in the context of STRING protein association network 641 54962 1111 63967 23129 545 9064 3176 4171 3783 9575 57586 1408 653 4086 29109 93 55620 652 805 801 5753 9241 202559 10657 2534 3553 654 7402 65266 5913 29949 53833 375790 50604 7827 56265 58985 3611 2322 5728 7529 4145 7534 10971 7532 2810 7531 9723 319101 3606 345275 7850 28234 PMC6557692__F1 Pro-Inflammatory Cytokine Activation of NFKB in Synovial Fibroblasts 7124 8772 5970 331 PMC6557761__F5 Evaluations on Substrates of FBXL Family E3s(A and B) Known (red edge) and predicted (gray edge) ESIs for FBXLs 4175 1874 7029 55336 7157 8881 51343 983 1017 898 890 7529 4193 2033 5934 1387 1026 51434 1793 9451 79365 10436 3313 26259 8536 23291 3329 1408 8148 26224 1457 26233 54850 1407 54431 7417 55215 3320 7520 5440 1163 11060 975 4792 55850 6520 10940 1786 4683 2962 29089 1642 153090 23163 64839 5901 11186 57154 5520 11051 5879 3190 5590 4794 6626 1499 5430 51684 836 2960 51588 3295 6606 11073 8554 6629 7867 207 10140 3305 1488 1655 8021 79176 5066 PMC6563036__F2 mTOR Signaling pathway 5163 7248 7249 5728 64223 253260 64798 PMC6566886__F4 Adiponectin-induced signaling pathway 51094 79602 26060 581 3667 3717 6774 2475 7249 5728 847 PMC6568224__F1 Necroptosis signaling pathwayNecroptosis can be caused by a variety of stimuli, including the ligands of the death receptor, TLRs, IFN receptors, and certain pathogens 7124 7099 8717 7186 8737 1540 7098 841 197259 836 840 11035 PMC6580174__F9 Ingenuity Pathway Analysis Molecule Activity Predictor algorithm indicated that loss of nuclear matrix protein 4 (Nmp4) elevates protein folding and attenuates endoplasmic reticulum (ER) stress-induced apoptosis 258010 596 3313 5887 9373 22937 3638 22926 10808 1649 10277 7415 51182 5599 468 3320 56886 2923 7186 5609 84447 811 79139 9695 11253 55432 23471 29927 10131 7494 55666 51035 821 5589 3306 55768 27248 10956 4217 267 6400 PMC6580320__F1 unctions and subsequent pathways of eukaryotic initiation factor 5A2 in human digestive system neoplasms 6010 56648 55902 2194 9112 PMC6580575__F4 Mechanistic diagram of NGF and ILM-mediated proliferation promotion by regulating cell cycle of Müller cells 4803 595 1019 1017 PMC6580702__F8 Negative regulators of NRF2 are found in autophagy 64422 5870 23637 9140 79065 10533 83734 9474 9776 60673 8408 9706 9821 9817 440026 5861 PMC6581583__F3 Inflammatory response due to the signaling cascade when HMGB-1 interacts with surface receptors TLR2/TLR4, TREM1, and RAGE 3146 54210 7097 7099 4615 2885 51135 3654 3656 7189 998 6714 5879 5163 3661 PMC6581679__F3 Non-canonical activation of HH-GLI signaling by oncogenic pathways 1956 2932 2475 2735 2736 8650 1859 8445 6662 23476 9149 4088 PMC6584407__F7 Signaling mechanism of MUS81 and CyclinB 545 472 10111 4361 995 5888 641 80198 983 146956 PMC6584411__F7 Mechanism diagram 26777 1021 1019 898 595 1017 1000 4313 4318 PMC6584916__F4 Downstream targets of Slit/Robo 999 6585 9353 6091 6092 64221 1000 4650 PMC6584916__F6 Roles of Slit/Robo in neurocyte navigation 1630 23767 6091 4753 64221 6092 6714 PMC6590462__F6 Japanese encephalitis virus (JEV) intracellular effect mechanism 10298 7494 22926 PMC6591114__F1 Ze brafish as a model system to delineate the role of heme and iron metabolism during erythropoiesis 1371 5498 55240 7389 7390 8031 2235 51218 2242 212 5093 PMC6591147__F3 Mechanisms promoting regulatory T cell (Treg) development and immunosuppression in the tumor microenvironment 6367 4088 1233 4089 1017 942 50943 PMC6591840__F5 Potential mechanisms underlying EOC chemoresistance and the sensitizing effect of PI3K inhibition 1431 2475 999 1000 216 PMC6592230__F7 ATM/Chk/Greatwall/PP2A signaling model for normal mitotic exit (A) and for abnormal mitotic exit during recovery from mitotic DNA damage (B) 472 995 983 2029 5347 PMC6592994__GA Biological role of MALAT1 in cyclin D1, miR-363-3p and Mcl1 gene regulations 4170 1499 378938 595 324 PMC6594015__F6 Schematic depiction 5163 5164 3664 2475 PMC6594866__F2 Key cytokines and transcription factors involved in the regulation of megakaryocyte maturation 7173 4352 3553 2623 2313 2120 2624 4778 4855 6352 3479 PMC6595388__F7 Signaling pathway 8772 8717 7186 8737 51295 581 PMC6596190__F1 APP can be cleaved through amyloidogenic or non-amyloidogenic pathways 351 7908 2752 PMC6596841__F1 Gpr17 signaling pathway following lysolecithin insult 2840 10215 54739 PMC6600375__F2 TGF-Beta-induced growth inhibition and apoptosis 4089 331 4087 4088 7189 638 1612 993 PMC6601327__F6 Proposed model of OLFM4‐induced STAT3 activation mediated by the LGR5‐Wnt signaling pathway in HCC 8549 324 10562 6774 619501 847 PMC6601390__F3 Molecular characteristics of steroid hormone receptors in endometriotic tissue 7124 85004 2100 2516 5241 2099 6770 PMC6603234__F3 Outline of potential mechanism of sEH inhibition-stabilized EETs in inhibiting colonic adenoma—carcinoma sequence via targeting inflammation and its activated Wnt/mutant p53 signals 1733 4513 324 3845 PMC6604281__F1 Fanconi anemia curated map, based in the KEGG FA pathway 57697 91442 9894 55159 84126 675 5888 545 2177 55215 4292 57599 5395 7516 79728 5889 51426 5980 PMC6605495__F1 Nutrient flux through the HBP modulates protein O-GlcNAcylation 8255 8473 10724 PMC6608078__F2 PI3K/PTEN/AKT pathway dysregulation in prostate tumor cells 5728 3309 22926 7494 3572 PMC6609813__F2 Suppressive mechanism of regulatory T (Treg) cells 324 84890 50943 355 3902 941 942 5132 940 29851 PMC6613384__F3 Protective effects of fibroblast growth factor 21 in cardiovascular disease 59272 19 26291 PMC6613841__F8 Proposed mechanisms underlying the regulation of innate immune response by influenza virus H5N1/HM M2 protein 9474 57506 3665 3661 PMC6614380__F1 Pathways to B cell memory 920 958 29851 613 51284 8178 PMC6615902__F4 WNT signaling and regionalization of the GI tract epithelium 6657 1045 3549 6925 56033 6476 1499 22943 PMC6616108__F1 Processing of CD8 ppCT T-cell epitopes 567 6891 6890 PMC6616656__F2 Long non-coding RNA acting within the NODAL signalling pathway 10637 7044 199699 4838 60674 4092 110231149 4087 4088 4089 8928 55384 5308 400550 PMC6618030__F5 A suggested relationship between the defatting cocktail and intracellular lipolytic metabolic pathways 355 95 338 51 PMC6620619__F4 Platelets involvement in the pathogenesis of AAVs 7450 958 3383 7412 PMC6621562__F1 Ubiquitin regulations on mTOR signaling components 5728 253260 23239 3667 2475 64798 6446 23677 201163 9681 10641 6009 8131 11133 55846 652968 23334 9776 8408 7942 5163 5879 51256 7249 7248 PMC6623974__F2 Functional interaction network analysis 3383 6469 5727 2736 5159 5329 7412 6347 7186 PMC6627153__F2 PCOS–disease subnetwork 1 6230 6193 6194 6217 6207 6222 6203 6231 7412 6189 6187 PMC6627153__F3 PCOS–disease subnetwork 8 8648 10499 6502 1027 1387 861 7421 672 5499 8725 79980 57082 25936 10403 11130 79657 83540 147841 57405 PMC6627153__F6 PCOS–disease subnetwork 28 3303 3337 10273 5514 9878 3308 4170 3184 5500 5725 10075 1869 4627 4193 3725 5601 582 92482 583 9586 55212 11016 123016 4773 51592 PMC6627192__F5 Ingenuity Pathway Analysis integrating differentially expressed genes and microRNAs between imatinib-naïve (IM-n) and imatinib-resistant (IM-r) gastrointestinal stromal tumor (GIST) samples 9837 51203 51659 51053 324 11065 79733 990 7044 144455 4502 5933 55872 947 1734 80243 55388 PMC6627878__F2 Kinase signalling pathway 3575 3718 5728 5163 3716 2475 596 PMC6628043__F7 Biofunction analysis of differentially expressed genes from eWAT (A) Biofunction-overlay of the disease and function related to lipolysis in eWAT; (B) the disease and function in response to CLE in eWAT 3952 3988 338557 301 1950 5008 32 960 261729 7421 208 7422 7124 136 338442 9370 6778 79602 153 5563 85329 57104 23228 467 9663 50486 23175 5209 PMC6631643__F9 Schematic representation of macrophage-derived exosomal miR-501-3p in PDAC and the involvement of TGFBR3-mediated TGFB signaling pathway 7049 124540 999 PMC6641538__F2 In eukaryotes, iron acquisition is mediated through metal or metal-siderophore transport 2235 2395 51218 PMC6641558__F3 The proposed pathway for constitutive AhR signaling and crosstalk with Src 57491 196 405 367 6714 PMC6650613__F1 Schematic representation of the steroidogenesis pathway 1325 1584 1586 255324 PMC6658087__F5 Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice 7157 3458 7124 672 4792 5966 6774 6615 6667 5451 4609 8061 3091 7490 3605 22918 1906 2213 2624 2697 8517 284 155 11213 27 10152 3717 7424 3976 64332 6850 4843 5294 710 8626 4904 719 480 23765 6915 PMC6659691__F3 Interferon-gamma (IFNG) pathway and its modeled representation to demonstrate the step-by-step calculations for protein-protein interactions at each node in this pathway and as an annexure section of other pathways 3458 3459 3460 3717 2534 6247 9846 6772 3667 8660 355 759 22944 3551 1147 4790 6347 948 3592 3579 7852 2919 6351 958 2920 3600 4170 595 4283 959 3605 4609 894 941 7422 3716 942 PMC6659998__F3 FA/TAG metabolism in hepatocytes 3990 948 2194 32 31 2180 2168 47 2167 1149 63924 8694 1579 84649 10226 5346 123 1374 788 34 338 37 PMC6660578__F4 Genetic risk factors and synapse dysfunction in AD pathogenesis 8301 1191 348 28 54209 5336 274 2185 5663 5664 102 6653 23607 9507 5747 10979 PMC6664293__F4 Network visualization of the calcium signaling pathway with expression and GWAS information 3707 5137 5331 6543 51196 810 5534 6863 6547 147 23236 6866 814 5532 9630 146 91807 5530 6869 2911 5136 6865 85366 1131 5582 7220 817 56413 4842 1129 2925 886 5261 4843 2906 3356 885 5579 9127 5731 776 3362 5023 5566 6262 887 490 2774 952 779 22953 777 5567 3360 3274 107 488 185 113 10452 5613 7417 5159 293 7419 2065 5481 7416 291 6546 5153 775 2890 5026 773 1816 PMC6665304__F6 DISC1 at the synapse 23043 27185 5879 5058 PMC6667250__F3 Feed efficiency and the autophagy pathway 2475 9140 22863 115201 9776 25989 596 83734 64422 9474 8408 55054 10533 9711 7405 10400 4077 440738 PMC6667378__F1 Graph representation of the Signaling by NOTCH2 pathway as extracted from the Reactome database 102 23385 4192 4853 55851 51107 55534 5664 83464 10046 3516 54567 3714 28514 84441 182 1272 57534 54492 9148 9794 142678 7314 2033 6233 7316 7311 PMC6671870__F6 The role of IDO/kynurenine in cancer immunoediting 8205 3620 50943 PMC6674869__F8 Intracellular signaling pathways downstream of p75NTR and TrkA in sensory neurons 4803 7442 8989 PMC6674889__F9 The promotion of neuronal development by CD47 961 6714 7410 998 PMC6675034__F4 Full candidate pathway that represents molecular drivers of tumorigenesis in the sarcoma of patient 1 2130 57630 6505 7153 9915 796 797 5743 3569 4312 6790 3570 4914 238 5728 5296 207 10000 3716 2475 595 1978 64919 332 2114 466 PMC6675248__F3 Role of mTOR signalling pathway during protein translation 1999 1977 2475 PMC6678135__F7 Compounds that inhibit and activate autophagy 9474 10533 83734 64422 9140 22863 7405 9776 2475 8408 9706 PMC6679138__F3 Proposed model for the cellular response to complex DNA damage (CDD) induced by proton beam therapy (PBT) in chromatin 56254 9810 55167 PMC6682688__F5 ErbB/PI3K pathway regulation by miR-326 2064 2065 207 10000 208 4193 572 2475 2932 894 4609 7422 PMC6682711__F2 Autophagy signaling in HCC 5728 1499 7249 7248 6009 8408 PMC6682745__F1 WNT/Beta-catenin signaling and the potential role of heterotrimeric G proteins 1499 4040 4041 PMC6684519__F7 Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma 9618 999 619501 6935 PMC6692187__F1 IRE1A structure, activation and potential roles in cancer 7494 7186 3397 6678 5159 7422 PMC6693242__F1 The autophagy pathways in endothelial cells 8678 9776 199857 PMC6695454__F3 Therapies targeting p53 functions 4193 145270 581 PMC6697777__F7 CaSR-mediated signaling and mesenteric artery relaxation 846 594857 156 1573 PMC6698799__F4 Proposed molecular mechanism of regulation of the pyrin inflammasome 6010 5586 5585 718 3606 PMC6698931__F1 The Function and Therapeutic Potential of Epstein-Barr Virus-Encoded MicroRNAs in Cancer 7124 355 8717 8772 7186 56993 8887 843 841 637 581 572 842 836 PMC6701246__F1 Mechanisms promoting macrophage phagocytosis of AC by lipid mediators 301 2358 2854 2841 6010 6774 3553 PMC6701373__F2 Transforming growth factor-Beta- (TGF-Beta-) induced EndoMT 4092 4087 4088 208 2475 4089 1019 PMC6702832__F7 The NFE2L2 pathway in fibroblasts 2810 4780 1432 4094 PMC6704288__F5 Proposed model of the combined effect of ROR1 inhibition and erlotinib treatment in non-small cell lung cancer cell lines via inhibition of the AKT/mTOR signaling pathway 3667 4919 5728 2475 1956 PMC6705128__F2 DUBs regulating TCR signaling 940 920 27040 102724566 8239 10892 7535 56957 1540 11274 9958 4193 PMC6705574__F8 The mechanisms underlying contributions of YAP/TAZ/Beta-catenin to the spinal central sensitization after nerve injury and regulation of dCTB on YAP/TAZ/Beta-catenin and Hippo signaling pathways 4018 4485 324 1499 2932 9113 26524 60 PMC6710175__F3 Hepatocellular carcinoma development in the Mat1a knockout mouse 1571 5245 596 PMC6714585__F1 Hedgehog signaling pathway 6469 6608 5727 51684 2736 2737 2735 4609 PMC6714585__F21 Most potent small molecules capable of inhibiting Hh pathway with their mode of action 6469 6608 5727 2735 2736 51684 PMC6717912__F1 Immune cell development and trafficking to the heart 2833 3383 729230 6352 3553 2919 3576 2920 4283 7412 8178 1878 PMC6718713__F1 Microglial signaling pathways determining development of cells with divergent abilities 4282 7124 3716 9021 5728 51135 6366 4792 50507 2668 1270 594857 9641 PMC6721652__F4 Drugs developed against canonical WNT pathway components 22943 50964 1499 8658 324 64840 4040 PMC6721815__F2 MAPK signalling in the context of wild type BRAF and mutant BRAFV600E 2885 4763 4893 673 57646 PMC6721815__F3 Adaptive response-mediated resistance to BRAF inhibitors in melanoma 2885 673 1956 2065 57646 101927152 4286 6663 7942 PMC6724557__F3 Model of TNFR2-mediated regulation of NFKB transcriptions factors in Tregs 7186 108348016 5970 5971 PMC6731300__F9 The proposed model 23612 2876 140809 PMC6733035__F1 Lineage of Cytotoxic Innate Lymphocyte Differentiation 8483 4566 999 3601 PMC6735542__F1 SLC3A2 in regulation of autophagy activation and cell radiosensitivity 6520 1690 23657 8140 2475 PMC6738915__F6 Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae 9817 8452 9978 4094 PMC6741997__F8 Model of the neuronal death pathway involving Cdks 6647 1020 1019 1021 1017 PMC6743980__F2 Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics 5340 1003 7436 7046 3383 6010 1956 PMC6744711__F2 Cross-talk between DNA damage and immune response 115004 3661 545 472 3659 PMC6748048__F4 Hippo Pathway Mutations in Human Diseases 4485 60485 5784 9113 26524 4771 2776 2767 PMC6749995__F4 Lung microenvironment: an important regulator of tumour growth and metastasis 1378 5281 3553 7124 6374 6348 6351 6352 3579 240 7099 6279 6280 729230 4318 6347 PMC6750724__F5 Proposed biosynthetic pathway of pepticinnamin E 717 5108 4504 718 727 PMC6754810__F1 Activators and suppressors of OCT4 in cancer stem cells 324 2296 10533 1499 7424 29843 PMC6756575__F4 Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis 930 4886 6363 1440 942 3569 728 4312 10563 51764 284 3576 4318 6696 10631 9934 3162 7057 PMC6757020__F10 Illustration of pathway signalling where phosphorylation signalling PTMs have been sequenced and annotated in melanoma tumours from patients 5163 1019 2475 596 4286 5077 6663 1029 4157 PMC6761106__F2 Suggestive model for receptor-mediated pathway involved in CD biology 4340 7189 7099 10537 23 4615 7124 6608 PMC6762067__F1 Ten simple rules to create biological network figures for communication 1950 2147 108348018 4893 7314 5590 3630 369 3068 351 23237 1956 10253 4692 PMC6765066__F12 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases 3146 7099 3576 4318 4353 PMC6766640__F3 Convergence of the TGFB and collateral signaling pathways regulates transcription of the profibrotic PAI-1 and CTGF genes 10207 154796 9113 26524 166824 374 174 2246 3398 113451 4609 1499 324 6657 PMC6767550__F2 Canonical and noncanonical signaling pathways of NOD1 and NOD2 637 331 10392 64127 8767 55054 10454 3661 57506 29110 PMC6769439__F8 Possible mechanism of action underlying the protective effects of maltol against APAP-induced hepatic injury through inhibition of oxidative stress-mediated activation of the NFKB pathway and apoptosis and regulation of the PI3K/Akt pathway 8717 8772 842 841 836 351 PMC6769697__F1 Schematic depiction of copper and platinum distribution in tumor cell 540 538 4015 475 9973 10063 6647 PMC6770144__F1 HER2 signaling pathway 5728 2475 4193 3725 2353 4609 595 898 1021 1019 1017 PMC6770144__F2 Mechanism of TRA/GO action 6955 7186 8717 108348016 8772 197259 7188 PMC6770264__F1 Bone metastasis physiopathology: implication of cancer cell-microenvironment interactions and therapeutic targets 7852 652 6387 920 PMC6770832__F6 Hypothetical signalling pathway that illustrates how the various pathways in this review may be connected, which is partially informed by preliminary research 7040 7046 355 1616 581 2309 PMC6770863__F1 TLR4–p38B MAPK–C/EBPB signaling pathway mediates the coordinate activation of UPP and ALP in cancer-induced muscle catabolism 4615 114609 7189 8408 23304 23710 7099 PMC6770886__F2 Rac3-mediated mechanisms in cancer 5881 7410 10519 28964 56961 382 PMC6771146__F4 Co-expression analysis of genes overexpressed in Puławska pigs, characterized by high feed conversion values 4538 4541 4535 4537 4513 10875 4508 4539 4540 4060 4519 4512 4509 302 6281 PMC6771392__F7 Model of HROB function in homologous recombination 84515 254394 78995 5888 113510 PMC6778255__F8 Schematic view of the role of AvB3-int in PD-L1 expression and antitumor immunity 3716 3717 6772 6773 920 3466 PMC6779857__F1 The core components of the Hippo signaling pathway 4485 60485 9113 26524 7003 PMC6780401__F3 Impacts of mutations in the TGFB signaling transduction components contribute to PDAC development 3845 4280 133 4086 7454 7071 7045 659 7046 PMC6785638__F5 Calcium signaling pathway is overrepresented in the specific differentially expressed genes altered by alfalfa intervention during the preweaning period 56975 3270 6769 5579 4843 10891 6095 PMC6788945__F3 Sex-differential regulatory network 643866 23351 56948 8796 1520 55857 4303 7173 PMC6791355__F2 Cdc37 controls a network of intracellular protein kinases 11140 367 8408 PMC6796064__F1 Conceptualized overview of the association between inflammation and angiogenesis 3082 3458 3479 1381 1499 57674 PMC6798812__F11 Cell Therapeutic Strategies for Spinal Cord Injury 4803 627 1270 2668 122769 717 5979 2674 PMC6803282__F3 Mechanistic network analysis predicted by Ingenuity Pathway Analysis 1634 2335 6934 1499 1385 285 3624 2263 5327 7124 3091 2034 4323 6385 1437 8743 6387 729 4318 5744 629 22926 7184 7001 6513 811 7494 3309 3576 3161 2597 3486 6696 11065 PMC6803376__F5 In the presence of the Ter mutation in Dnd1, members of mTOR, Hippo and Bmp/Nodal pathways have altered expression, with some transcripts indicated as direct targets of DND1 4838 2475 253260 4086 5728 154796 10000 7249 7248 4089 6009 57521 6446 7532 6997 PMC6803553__F3 Signal transduction of GDF11 10220 25805 238 7189 PMC6804972__F3 Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance 1869 1158 335 1490 488 23493 7421 3759 845 1827 59272 3762 4879 6548 4883 2305 4634 604 7060 217 PMC6812026__F2 Important metabolism-related cellular signaling cascades where FKBP51 was shown to play a decisive role (see main text for further details) 1325 3667 208 7350 PMC6813799__F1 Key Steps of Reverse Cholesterol Transport 3949 3931 53369 8647 5360 9619 PMC6815035__F5 The miRNA–mRNA interaction networks containing eleven lipid metabolism or deposition related pathways 847 51422 9415 84254 64834 122618 5563 51 3931 6476 PMC6817822__F9 PR55A regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells 4485 9113 26524 PMC6819196__F8 HIPPO SIGNALING CONTROLS NLRP3 ACTIVATION AND GOVERNS IMMUNOREGULATION OF MESENCHYMAL STEM CELLS IN MOUSE LIVER INJURY 9242 4485 9113 26524 1499 7494 114548 PMC6819784__F2 Macrophage infection affects host metabolic state and can induce an M1 profile 3458 3459 7099 2147 3091 7351 PMC6820534__F6 Supposed mechanism 2925 2869 998 2316 2317 5328 961 PMC6828744__F1 Long noncoding RNA: TRIMming the viral load 7098 54106 51284 51311 1283 57506 9447 3428 7706 10010 115004 7187 3661 3665 PMC6835611__F7 Inflammatory signaling pathway and the resulting downstream responses 3596 7412 3383 4318 PMC6836431__F1 mTORC1 and its signaling networks 4855 4853 4851 4854 5728 5163 2932 2887 6009 7248 7249 64798 2475 64223 9675 8408 468 3091 PMC6839211__F8 MicroRNA-182 in ovarian cancer 51514 990 4176 9055 79892 1026 1021 4175 4999 51659 9918 23397 4998 8317 1019 64785 1894 84296 675 23594 29127 1499 7153 5888 332 3845 10051 4172 4171 595 4173 10592 3161 64151 4174 9837 23595 8318 5001 9493 2534 6119 5000 7525 55388 11004 PMC6843074__F4 IL-22 signaling pathway for expression of acute phase response proteins 50616 1019 6347 6280 6278 6279 4314 4312 6374 PMC6843238__F2 ALDH1A1-retinoic acid-HIF-1Alpha-VEGF pathway is activated in breast cancer MCF-7 cells (A) 216 6657 4609 5915 7852 6387 6714 2064 54790 6256 PMC6843654__F4 Top three molecular networks identified by Ingenuity Pathway Analysis (IPA): (a) Network 1 54557 84033 9700 54476 80168 161742 4820 4638 4204 1399 4771 10579 55915 11214 23314 5791 23064 11200 4086 10021 1512 5627 1520 6678 284217 8702 1833 56254 7273 4685 7068 6801 PMC6849407__F8 Schematic diagram of the potential mechanisms for CDDO-Me–mediated Nrf2 activation in CHF 2729 1728 4513 9870 9817 PMC6854373__F8 Graphical abstract of how EGFR signaling pathway and downstream effector inhibit the miR-124a expression and the role of ETS2 in insulin production in pancreatic beta cells 3170 2114 3651 PMC6854496__F1 RIG-I-like receptor (RLR) activation by various RNAs during DNA virus infection 8602 57506 100873408 8446 29110 7263 29074 3661 3665 PMC6854743__F8 Signaling pathway of the Akt + diuron-induced glioma 29128 5111 1786 PMC6858476__F1 Schematic overview of steroidogenesis and corresponding urine steroid metabolites 1583 6770 3284 1589 1585 5447 1586 1584 3291 3290 2056 8644 3293 6715 3294 100187761 6822 9060 PMC6858495__F7 Activation of PC-3 by PAC-1 and its derivatives via chelation of labile inhibitory zinc 7911 673 4827 PMC6859340__F7 Mechanism of Cdc42/Wnt/Beta-catenin signaling pathway in ADSC-derived IPCs 89780 998 324 1499 6934 3651 4760 PMC6862675__F4 IPA® analysis of signalling pathways of the genes differentially expressed upon lysozyme treatment 7316 7431 2006 2534 133 2657 2537 5329 27179 10657 55791 5996 PMC6863093__F4 HVEM behaves as bidirectional switch based on environmental signals: 151888 4049 11126 7186 3550 PMC6863963__F1 Conflicting roles of RASAL2 in different cancers 2475 6657 7249 2113 960 7422 2932 9462 1499 3843 PMC6866135__F1 IRAK1 kinase drives distinct prosurvival responses to microbial infection and ionizing radiation 4615 5300 51135 3654 7189 PMC6873206__F1 YAP regulation by mechanical stimuli 4485 9113 26524 PMC6873406__F13 Non small cell lung cancer pathway logic circuit with miRNA 100616464 2885 1950 407018 2064 406952 442902 5728 PMC6873535__F2 Effect of RAS signaling components on neural stem cell differentiation 4763 5781 5894 673 3265 PMC6877906__F1 MyD88-dependent and TRIF-dependent TLR signaling pathways 7100 7097 10333 7099 114609 4615 3656 3654 51135 7098 695 51284 54106 51311 7189 23118 257397 10454 7187 3665 3661 948 929 7096 PMC6879940__F1 Proposed mechanisms of podocyte susceptibility to lipid-mediated injury 948 19 27293 857 6646 114548 7038 PMC6881749__F4 A proposed model of the impact of elevated levels of circulating IL-6 on skeletal muscle redox balance 1728 3066 847 2539 PMC6883319__F7 MetaCore-generated pathway showing differentially expressed genes involved in ATP metabolism 5168 5169 683 80347 9061 9060 2272 10846 50808 204 26289 5142 5137 5143 27115 5144 PMC6887797__F1 TSC2 mediated crosstalk between the Akt/mTOR pathway and the cyclin D1-CDK4/6 axis.The cyclinD1/CDK4/6 axis is responsible for increased phosphorylation TSC2 and TSC1, and promotes the phosphorylation of the mTOR substrates, 4E-BP1 and S6K1 1956 7249 595 7248 1021 1019 2475 PMC6887802__F3 Lung cancer and autophagy pathway 2475 8408 9776 8678 PMC6887802__F6 Pulmonary arterial hypertension and autophagy pathway 10533 2475 8408 9474 9776 PMC6888001__F8 G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules 3717 7424 1956 PMC6888217__F1 Extracellular and intracellular (canonical and non-canonical) adenosinergic pathways 100 952 84890 367 5167 8544 PMC6888217__F3 Extracellular ADO on subsets of macrophages 942 968 941 9332 84890 PMC6888641__F1 PI3K/mTOR signaling cascade 5163 5728 23678 7249 7248 572 9681 983 596 6009 4193 3725 4609 8408 894 PMC6888825__F7 Proposed transcriptional regulatory system for VA and SA catabolism in Sphingobium sp 23269 3978 5132 PMC6892982__F1 Autophagy regulators and functions associated with anti-aging effects 7249 7248 7942 5071 26747 8887 4077 139341 664 PMC6894087__F7 Schematic drawing that illustrates the signaling pathway involving mTORC1/rpS6/Akt1/2 and Cdc42 utilized by NC1 peptide to induce Sertoli cell BTB remodeling in the testis 6194 207 208 998 2059 PMC6895440__F3 PGK1 involvement in drug resistance 5230 8061 1786 1788 5424 1789 3091 PMC6901542__F6 Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NFKB pathway activation through RPS3 5212 3934 6188 PMC6901970__F1 Regulation of Tfr cell differentiation and function 29851 50943 940 2308 5728 6774 3586 PMC6902583__F6 Target network of bradycardia 183 4878 10911 285 5624 10371 5972 1128 146 152 134 551 147 3736 1132 4988 10021 153 3757 1131 1133 154 150 155 1129 776 3784 2697 5879 50507 811 387 5999 84287 1536 6737 6671 9615 5350 342538 8913 151 366 348980 PMC6903413__F5 NFKB activation in inflammatory cells 3603 4615 7186 8717 3569 3606 3383 7412 114548 834 PMC6904332__F3 Upregulation of SESN2 under ERS and its protective effect on ERS-associated cell death 7038 22926 7186 1998 83939 7494 468 83667 PMC6904929__F2 MicroRNA Mediated Regulation of Immunity against Gram-Negative Bacteria 7097 7099 4615 7189 54106 PMC6905197__F1 Hippo signaling pathway 60485 4485 55233 9113 PMC6908615__F8 Illustration on the possible underlying pharmacological mechanism of neurotrophic activity of SCH in cultured hippocampal neurons 5687 10113 6804 5019 3187 PMC6909948__F4 cAMP can regulate multidrug-resistance in lung cancer through the regulation of plenty of downstream effectors, which is participating in the cAMP signaling pathway such as the classical PKA and CREB or some other useful effectors 2932 1499 472 51548 1080 PMC6912360__F8 Mechanism capable of expressing or inhibiting an effect of Temozolomide (TMZ) 4436 2956 4292 5395 4255 PMC6912580__F3 Molecular pathways regarding neuronal survival on which QC seems to assess their effects within the brain 627 4803 5163 2475 PMC6912814__F1 Summary of the main mentioned markers of the autophagy-lysosomal pathway (ALP) 5071 65018 120892 3916 3920 23400 PMC6913091__F3 Pushing the envelope: LPS modifications and their consequences 7099 4615 55824 405 PMC6913815__F1 An overview of the 3 unfolded protein response pathways 1628 22926 7186 83939 468 7494 467 PMC6914705__F10 Schematic representation of how SteA suppresses the nuclear factor kappa B (NFKB) pathway 8454 55832 4738 6500 PMC6916339__F2 SHIP2 regulates the insulin signalling pathway 5728 23607 5266 PMC6925247__F7 TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2Alpha-ATF4 pathway 261726 83939 10533 4077 468 PMC6929101__F2 TGFB alteration in colorectal cancer (CRC) cells 6010 3458 2919 3579 7422 7424 1499 PMC6929103__F3 KEGG based pathway analysis of 86 genes reveals their significant role in different pathways, as shown in the figure, such as immune response pathways 5350 1909 493 355 1910 3791 4208 10105 858 857 5175 1003 3122 5788 2335 947 948 3910 6696 PMC6933925__F2 Possible rational combination treatments for HH/GLI-associated cancers simultaneously targeting HH/GLI and HH-regulated immunosuppressive and tumor-promoting signals 8205 3586 729230 6469 2736 3569 3589 3553 6774 3458 6368 PMC6934036__F5 Inhibitors used for antitumoral therapy 54894 84133 1499 4040 4041 4609 8549 2932 5218 607 6908 324 PMC6938674__F8 Targeting CDK7 for treating Yap/Taz-driven cancer 4485 1022 27343 11201 PMC6938856__F10 Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis 999 2475 595 1499 PMC6939200__EV5 Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor 1499 999 252983 154796 PMC6941108__F3 Visualization of lncRNAs and mRNAs in enriched pathways 389634 10112 9447 3161 9134 10403 113130 9021 7298 8318 9232 51659 3429 941 5236 10381 4605 983 4261 653361 701 1063 7083 157570 3113 6241 3115 5347 3576 30835 990 1869 891 22974 4751 972 7153 699 991 2760 1870 9493 10875 64151 11065 55388 55355 10866 100499227 PMC6941425__F6 Targeting citrulline-specific B-cells using a CCP-STAL 933 613 1356 PMC6942366__F8 The role of HULC in hLCSCs 728655 100033819 10533 64422 23411 PMC6943912__F1 Immunogenetic effects of low dose (CEM43 30) magnetic nanoparticle hyperthermia and radiation in melanoma cells 6370 10803 6366 6363 729230 1236 6351 1233 6367 2833 1232 6348 7852 6368 6358 6360 58191 10663 6357 284340 6354 6846 6347 6356 6369 1235 PMC6943935__F3 Noncanonical IL-17 signaling 26018 1956 6850 9618 6654 7189 79092 8915 6364 PMC6944116__F5 Protein interaction and functional clustering of identified hits and known UV‐G2 checkpoint components 6597 4841 2547 7508 7415 11178 23513 51588 2237 142 1643 1642 54962 7486 6118 56852 8078 5518 5515 10776 545 6117 5111 7325 5888 5520 84930 2029 114907 23612 6502 3303 4000 1019 7832 1029 6774 3725 9518 PMC6947613__F1 Molecules and pathways involved in the effect of statins on NO production by endothelial cells 1401 6010 5879 857 4846 PMC6952538__F3 Intermediates of the cholesterol biosynthetic pathway function as RORGagonists 38 3157 3156 2222 6713 4047 1595 6309 10682 51478 50814 7108 1718 1717 1581 9023 10858 PMC6952807__F1 TNFR1-mediated survival and cell death pathways 7186 8717 1540 10454 23118 8737 8772 841 11035 197259 PMC6957567__F1 Brief overview of DDR signalling 4361 472 3014 1763 641 11073 545 84126 5888 675 79728 672 PMC6958506__F4 A summary of miR-205-5p expression regulation and direct targets of miR-205-5p and their biological effects 10413 6935 1869 3915 154796 2065 4853 2064 2247 7157 3280 PMC6961892__F7 Liganded T3 receptor B2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production 7200 7252 1081 2624 4487 7536 5307 PMC6962593__F3 Toll like receptor 4 (TLR4)-dependent basal lung transcriptomics 3273 84666 6696 1510 4321 3553 1230 1234 2047 573 374 3569 6774 467 2353 1051 1906 3164 3725 1958 5743 3052 22873 23269 323 23131 23036 51015 57178 677 51199 23331 9698 25831 1783 9937 9520 4651 10553 23645 51611 80228 11010 5372 1677 9330 4351 1521 51649 PMC6966464__F2 Four ErbB receptors 7039 1950 3084 685 1839 367 9542 2885 6714 25759 2064 2065 2066 5728 572 2475 PMC6966492__F1 Cell death pathways triggered by the temozolomide-induced DNA lesion O6-methylguanine 4255 545 472 6477 28996 355 581 PMC6966636__F9 HMGCS2-mediated ketogenesis impacts liver cancer progression and treatment 3158 619501 581 999 595 1000 PMC6966712__F8 Hypothesis of XIST/TSIX/PD-L1 regulation 9383 7503 79923 2475 PMC6978354__F6 Differential methylation of genes in the B-cell receptor signalling pathway 933 971 5777 6850 973 27071 4067 7410 29760 5879 695 5336 5530 2885 6655 3265 5605 2353 1610 10892 5579 1147 8517 3551 4790 8519 4792 5290 930 1380 PMC6985271__F1 Type-I interferon signaling and ISG15 3454 3455 3716 7297 11274 6502 9636 PMC6986448__F3 KISS1 in breast cancer progression and autophagy 4314 4318 4852 10893 5617 4323 79874 4313 2796 3479 6670 6667 2099 5970 7020 2353 4790 9439 27044 PMC6986449__F2 Differentially methylated promoter regions of genes in PI3K-Akt and NFKB signaling pathways during acute malaria 2885 5728 5163 84969 9760 11140 7248 572 7249 4193 6009 1499 79923 595 2475 1977 PMC6990114__F3 Hippo pathway plays vital role in mammalian immune system 115004 5872 81704 29110 5879 2308 2309 3661 50943 PMC6991658__F9 Mechanism diagram 1000 999 472 9833 1017 1869 PMC6994382__F2 Gene-network for genes mapped to 16 variants which replicated in both Hispanics and African Americans 8320 1233 3592 84890 4179 3601 28955 3558 1378 3559 3075 23274 3600 914 1493 10972 965 8218 942 10960 54732 10959 1212 3394 29121 PMC6995521__F7 Differentially expressed proteins in the Cyp27a1−/−Cyp46a1−/−Soat1−/− vs 670 6563 95 2582 8649 2548 PMC6996149__F2 Acidic pathway of bile acid synthesis in metabolic regulations 22937 9420 64241 64240 355 PMC6997465__F1 Immune system and nociceptor activation 7124 7442 8989 89796 4803 2475 PMC6997467__F1 Signaling pathway of ncRNAs in RA 7096 7097 4615 54472 7189 51295 10454 23118 1499 4703 PMC6998289__F1 Small peptides encoded by circRNAs and lncRNAs regulate tumor proliferation 57646 5163 11201 54623 51514 257218 55294 6657 595 5111 PMC6998289__F2 Small peptides encoded by circRNAs and lncRNAs regulate tumor invasion, metastasis, and proliferation 404266 3178 2932 23644 167227 55366 1499 PMC7000168__F1 Summary of myocardial cellular effects and the injury response induced by doxorubicin 675 10725 2626 2475 4312 836 355 7097 7099 PMC7001001__F4 Bioinformatics Analysis of miR-124-3p and Its Downstream Targeted Genes(A) The genetic interaction network of miR-124-3p built by Biovista Vizit 6093 6262 823 2934 2885 259230 307 5970 1500 3688 857 5045 2319 2332 6464 7855 PMC7002027__F2 Phagocytosis checkpoints as new targets for cancer immunotherapy 567 961 140885 4035 10859 51311 51284 115004 54106 3661 PMC7002394__F10 Insulin signaling cascade targeted by WEE in PA treated HepG2 cells 3667 5166 5947 10170 PMC7009407__F7 Schematic and simplified diagram of some salient features of AHR signalling pathways Black solid arrows depict the canonical pathway, dashed arrows alternative pathways, and the red solid arrow an example of their intersection 1499 4513 351 57491 PMC7010080__F1 Compartmentalized NAD+ metabolome in humans 93100 203447 349565 51547 22933 23411 51548 23410 23409 23408 142 952 64802 23057 PMC7010257__F5 miRNA expression in advanced Algerian breast cancer tissues 2335 1956 2065 2064 1978 406985 494337 406991 406959 406958 406911 406892 4193 7157 2146 PMC7010683__F8 Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1 3082 2549 2475 PMC7012489__F1 Canonical and non-canonical nuclear factor kappaB pathways 958 330 596 PMC7013084__F1 CSCs alter the composition and functional properties of immune cell subsets, which results in an impaired CSC recognition and elimination by the immune system 140885 961 6347 6352 50943 920 PMC7014257__F2 Strategies to overcome anti-angiogenic therapy resistance 7422 8205 6362 1601 1969 PMC7014277__F3 Role of protein phosphatases in the DNA damage checkpoint deactivation 3014 545 472 993 5347 PMC7015249__F9 Serum amyloid A 1 (SAA1) induced muscle atrophy 6288 5066 1445 3569 5970 7096 7097 7099 PMC7016469__F6 Cyclooxygenase 2 (COX2) promotes ovarian cancer cell proliferation and invasion via the prostaglandin E2 (PGE2)/ nuclear factor-kappa B (NFKB) signaling pathway 5732 4513 6774 4313 4318 PMC7016612__F2 DNA double-strand breaks (DSBs) response pathway 9656 472 993 983 1017 1019 11144 675 5888 596 PMC7016612__F3 Crosstalk between primordial follicle activation and DDR pathway 9365 3815 5728 5163 672 472 7249 7248 675 5888 6194 2309 PMC7016717__F2 Janus kinase 1 (JAK1)/STAT3 signaling in DLBCL 3716 4615 6774 9021 4791 4792 64332 10538 596 4170 597 208 6446 100271849 3662 1958 3725 4609 PMC7016816__F1 Schematic view of the ferroptosis pathway 2937 2182 2879 6520 23657 7037 PMC7016866__F8 Model for the activation of Notch2 signaling in renal tubular epithelial cells under high glucose conditions and the possible actions of LE or LE/GC-KO in suppressing the Notch2 signaling cascade 9794 100188776 999 PMC7020042__F6 Schematic diagram showing D and DA on adipocyte differentiation through GSK-3B/Beta-catenin signaling in ASCs 1499 2931 324 355 1050 PMC7023504__F5 Mitochondrial redox signaling as essential part of branched-chain keto-acid- stimulated secretion of insulin 3712 4163 6647 6648 PMC7026265__F1 Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities 10330 22926 83939 7186 7494 468 PMC7028010__F1 UPR activation mediates beta-cell survival 83939 22926 7494 10628 468 6774 PMC7029350__F5 Class I PI3Ks activated by receptor tyrosine kinases, such as epidermal growth factor receptor, can phosphorylate PI 4,5-bisphosphate to yield PI 3,4,5-triphosphate in the cell membrane 5163 572 2932 PMC7029350__F6 Wnt signaling is regulated by the cytoplasmic Beta-catenin destruction complex, which consists of the core proteins AXIN, adenomatous polyposis coli, casein kinase 1, and glycogen synthase kinase 3 1499 324 595 4040 4041 PMC7031270__F6 IPA generated networks of transcription factors and differentiation markers 2312 1823 7051 1828 688 1999 3725 29841 8626 3664 2353 8456 4851 595 8538 5307 1030 3713 3848 3858 5080 1602 94234 PMC7037237__F1 Simplified schematic of type-I IFN induction and major IFNAR signaling pathways 7124 7099 3455 3454 7297 7098 4615 54106 51311 51284 51135 10379 3661 6772 115004 3659 3665 PMC7039327__F2 B-cell receptor signaling triggers formation of a multicomponent “signalosome,” which can activate BTK, AKT, PI3K, PLCG2, and BLNK, and CD19, a coreceptor important for PI3K activation 613 695 4067 6850 29760 5336 5880 5879 387 391 973 974 930 PMC7039855__F2 Wnt/Beta-catenin signaling in DCs and tumors in driving immune suppression and immune evasion 1499 941 942 6351 6375 6925 1236 2475 3553 920 50943 4040 4041 2829 PMC7039994__F4 Chromatin accessibility is associated with the changed expression of miRNAs that target members of the Hippo pathway during myoblast differentiation 54361 8322 4771 122786 23286 11186 1856 60485 1453 5515 5520 6789 55844 92597 9113 2932 5516 7529 5501 10297 8312 6932 10413 6591 7003 8463 25937 4656 PMC7040094__F1 C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity 79595 160364 283420 64170 10892 8915 3553 PMC7040165__F2 Controlling pluripotency using small molecule inhibitors and growth factors 7044 6657 9314 64321 79923 2247 652 3976 PMC7046484__F8 Schematic illustration summarizes the epiregulin promoted trophoblast cells invasion by targeting poFUT1 and O‐fucosylation on uPA, which stimulated PI3K/Akt signalling pathway and MMP 9 activity 5340 1956 23509 4318 1000 999 PMC7047199__F1 Radiation-induced effects on pathways related to mitochondria in cardiac cells 2941 581 5465 9817 192111 PMC7048745__F3 Ubiquitination in immunological tumor microenvironment (TME) modulation 84282 6048 7189 83737 54106 51311 51284 7098 57162 4615 57506 54941 10475 7706 10010 373 7187 23118 10454 57534 142678 23220 3661 3665 115004 22954 267 81844 27005 29110 11060 PMC7053300__F5 MiR-17 family miRNAs are predicted to target the p21/CDK/E2F1 pathway to modulate the G1/S transition of the cell cycle under oxidative stress 4088 4089 1021 1019 595 894 5925 5933 5934 1869 PMC7054750__F1 Active integrin internalization and trafficking pathways 5225 9230 6237 23011 9784 5792 PMC7055240__F3 Cholesterol biosynthesis pathway and gene expression identified through RNA-seq 47 65985 3156 4598 10654 4597 2224 1718 1717 4047 51478 50814 PMC7057837__F3 Role of RUNX Family Transcription Factors in DNA Damage Response 545 142 641 861 864 2177 55215 PMC7058935__F11 Wnt5b integrates with Fak1a to mediate cell movements during gastrulation 81029 6714 23002 998 5879 6259 PMC7059188__F2 Soluble factor-activated signaling pathways in fibroblastic cells in CNT-exposed mouse lungs 7076 967 4087 4088 4089 PMC7063117__F3 Regulatory role of miRNAs in OP-associated pathways 860 1956 27250 7189 23118 2932 324 1499 494334 6319 4772 867 2078 4040 4041 PMC7063406__F2 Epithelial and Epidermal barrier dysfunction: Various molecules involved in the signaling pathways shown in figure are maintaining the epithelial and epidermal barrier 1956 2984 4615 57217 847 595 7124 3603 3569 PMC7063815__F1 Relationship between mTOR and tumors 6009 7186 56957 165918 64798 2821 2475 3014 5728 PMC7066027__F5 Roles of miR-30c family members in drug resistance 1956 5756 7534 PMC7066079__F7 Proposed model to illustrate the role of FAM83A in the Wnt and Hippo signaling pathways 84985 4485 60485 324 2932 1499 595 PMC7071425__F9 Elav1 pathway for mRNA stabilization 7534 8125 7514 6418 8021 5578 PMC7071987__F1 Fundamental knowledge on IL-17 biology 84818 7186 7189 10682 55540 920 132014 7124 6347 6374 2919 PMC7072296__F2 Regulatory models of the Nrf2-ARE pathway induced by arsenic 8452 9978 9817 PMC7072634__F1 Ultra-structures, components, and functions of intermitochondrial cement (IMC) and mitochondria-associated ER membranes (MAMs) in male germ cells are summarized 54456 11022 221400 29118 1618 56165 84944 122402 1656 121355 54464 26136 PMC7072717__F1 Store-operated Ca2+ entry pathway (SOCE) 7220 7223 84876 6786 PMC7072849__F9 Visual summary of the main findings of the study 344022 1499 6657 79923 145258 9350 3170 4838 8320 83881 10637 64321 6469 6660 2302 3169 1000 2335 3875 6911 2294 PMC7073129__F1 Interactions between retinoid signaling and the Wnt/Beta-catenin pathway on the cellular level for growth plate chondrocytes during endochondral ossification 4041 860 4322 1300 1499 1280 6662 PMC7073900__F1 Key hallmarks of the ferroptotic pathway of cell death 2182 246 2879 PMC7076373__F1 CDC1 DC development 5132 170482 3394 55509 3398 283420 2829 PMC7081792__F1 Hippo and hyperplasia – TEAD promotes mTORC1 activation post-injury 5728 4485 9113 26524 6009 7003 6510 PMC7084349__F2 Translational control in antidepressant action 2475 1938 627 29904 PMC7092730__F1 Three adipogenic transdifferentiation pathways 4487 10682 63976 64641 650 79813 574455 3479 5081 4617 PMC7093136__F5 Summary of signaling pathways and molecular events induced by Chlamydia to promote inclusion development and EMT induction, leading to complications 7049 1956 6866 4088 4089 999 1012 6935 PMC7096354__F4 Dysfunctional pathways of miR-15a and miR-24-1 1584 3884 862 150094 2315 6425 PMC7097917__F1 L-serine synthesis pathway 26227 29968 5723 6472 6470 PMC7098175__F3 Antitumor mechanism of CT 3479 3099 572 3717 1499 6774 7249 3091 3939 6009 23410 595 PMC7098264__F1 ApoE Isoform Specific Effects in AD 19 348 3949 4035 7436 PMC7098997__F4 Changes in proteins involved in the oxidative stress metabolic pathway 5805 5830 5190 5189 5828 5195 8504 5824 11264 4358 30 PMC7104317__F1 Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy 7098 23118 257397 7187 7189 10010 3661 7124 3569 3606 PMC7104985__F1 Schematic depiction of production and sensing mechanisms for type I interferons (IFNs) 3716 7297 7099 6772 51311 51284 3667 8660 57506 54106 7098 6773 6775 6774 6778 115004 29110 2475 3661 3665 PMC7105880__F1 Outline of the pathway of eicosanoid synthesis from arachidonic acid 4512 4513 4049 PMC7106581__F2 Graphic summary of physiological activities of Fndc5/Irisin that are elicited through pathways other than MAP-kinase signaling 8408 2475 4615 6774 7189 4088 2167 627 7099 2660 PMC7106955__F1 Main mechanisms of ferroptosis 7037 6520 8031 2879 100 PMC7110195__F1 Nucleic acid sensors inducing type I and type III interferons 170506 64127 9188 51428 1660 1653 115004 57506 4615 29110 PMC7112453__F1 NAD+ metabolism pathways in mammals 952 10135 23475 93100 203447 23057 349565 65220 PMC7115204__F2 Signaling pathway of G-CSF in breast cancer 652 3265 2475 5879 7039 4313 79923 8549 4440 PMC7118423__F2 The angiotensin-converting enzyme 2 (ACE2) signalling pathway involved in SARS-CoV-induced CCL2 expression 6347 1636 59272 PMC7118498__F2 TGFB 1 acts as a double-edged sword 7040 4087 4086 PMC7122041__F9 Coagulation profile of endothelial surface during normal (left panel) and activated state (right panel) 7018 324 5340 5091 7035 PMC7133748__F2 Nectin adhesion pathway (positive regulation of JNK cascade) was more active in the nonresponder tumors (upper panel) than in the responder tumors (lower panel) 6714 9855 998 PMC7137347__F1 LncRNA in regulating stem cell pluripotency 51548 79923 6657 100885779 4087 4088 4838 60674 4089 PMC7139528__F6 Nervous system interaction effects of the KEGG enrichment pathway terms and putative target proteins identified in A 4128 23236 3710 847 1128 1139 1129 7220 10681 2912 4842 50632 1812 1816 2353 1814 2774 1813 10000 100137049 239 5742 3360 3350 5594 2778 140805 43 5578 836 5604 3265 369 1312 10488 10411 351 3717 775 596 2534 PMC7139810__F7 Reciprocal link between the serine biosynthesis pathway (SBP) and MYC oncogene 26227 29968 468 2146 PMC7139953__F3 Mucins signaling in the benign and malignant pathologies of the colon 4585 4582 56667 960 2066 2064 2065 6714 7189 5163 1499 2309 4583 6774 4040 PMC7140515__F1 Crucial signaling pathways in CCA metabolism 22933 5728 8841 5160 2308 23411 7351 PMC7141637__F1 Proposed model for SARS-CoV-2-associated diarrhea 59272 7113 2475 PMC7142266__F1 Schematic elucidation of the FA pathway mechanism used during DNA repair 545 79728 7398 22909 2067 84464 PMC7142844__F8 Molecular mechanisms of SNRPG-mediated p53 targeting of TMZ-induced glioblastoma multiforme (GBM) growth inhibition 4292 6637 4255 1017 891 PMC7145703__F4 Evolutionary Basis of High-Frequency Hearing in the Cochleae of Echolocators Revealed by Comparative Genomics 2885 6772 1540 4772 338376 7042 2274 9846 7010 1513 29760 6850 4286 100187907 10379 PMC7145982__F1 Autophagy process and regulation of ATG proteins by PTMs 9474 10533 83734 9140 79087 64422 7405 9776 8408 9706 60673 65018 7416 PMC7147523__F4 CD11c+ microglia as a subset of microglia present through life and across conditions 5066 472 1435 961 140885 PMC7154099__F1 Schematic diagram depicting the regulation of osteoblastic-specific genes expression by lithium through activation of three major signaling pathways, including the canonical Wnt/Beta-catenin, PI3K/Akt and BMP-2 signaling pathways 50964 4040 4041 2932 4090 4086 324 5163 1499 4772 860 PMC7154114__F5 Systems biology is an interdisciplinary field that involves computational and mathematical investigations for modeling a complex biological mechanism 5347 1956 7428 51512 2305 10874 7157 693215 4193 3569 2353 595 2297 2523 1028 PMC7156293__F3 The MyD88‐dependent and MyD88‐independent pathways mediated by TLR4 ligation to induce NF‐KB activation and cytokine gene expression 7099 4615 3654 4118 51135 3656 7189 7124 5743 PMC7156751__F7 A simplified tumor environment model 3566 7097 7099 6773 3665 3606 3569 2919 3627 9021 6774 6772 3553 PMC7157599__F3 Molecular mechanisms used by members of the HECT E3 ubiquitin ligases to regulate Wnt, TGFB and Notch signaling pathways 57154 10075 4092 11059 83737 64750 23327 4087 4088 324 1499 4734 51366 11060 PMC7157668__F1 Mycobacterium evades macrophage apoptosis by induction of anti-apoptotic cytokines and miRNAs expression 355 7297 8772 9618 596 6774 572 581 10148 406991 29997 PMC7163447__F9 Proposed model for the role of mitochondrial biogenesis process in developmental fluoride neurotoxicity and protective action of RSV 23411 7019 4899 PMC7173364__F6 Apoptotic Cell Death Induced by Fractions F2 and F3 of Vitex Rotundifolia in T-47D Cell Line 2152 2147 581 PMC7175209__F1 Induction and initiation of cellular growth control and senescence via p53 or P16INK4A pathways 545 472 1021 1019 PMC7177421__F1 Receptor 4 (TLR4) general signalling transduction pathway 7099 929 4615 51135 3654 7189 3665 3663 PMC7177523__F2 Schematic figures showing various signaling molecules influenced by the CO-HO-1 pathway 5728 5163 347902 2932 7249 51256 7248 23411 6009 2475 PMC7177584__F3 PRDM proteins participation in signal transduction pathways, proliferation, and gene expression regulation 22943 3667 4088 324 2932 4087 56978 1499 4673 2475 11107 56981 63978 2353 3725 63976 639 1053 5055 6497 59336 388324 81792 PMC7178546__F1 Signaling Model from CAR Antigen Binding Through ERK Activation, Incorporating Models from literatureArrows and bars indicate activating and inhibitory interactions, respectively 930 3932 1445 8205 2885 3702 27040 652070 951 PMC7180223__F1 Gene ontology (GO) analysis of LOAD risk factors reveals the enrichment of genes in the trafficking pathway 51225 115701 124152 26047 55063 51741 84148 222950 8820 64231 123041 57091 2041 388325 10979 274 54209 6688 1378 8301 23607 945 3123 348 2185 116449 102 1636 3635 2206 6653 1191 9510 83464 9507 PMC7181720__F1 Proteomic analysis of the OTULIN protein complex 90268 4397 7249 3099 54552 9698 114882 22954 27032 PMC7183876__F2 MiR-21 and miR-17~92 promote cyst growth 27250 5465 2475 5311 5310 PMC7184480__F2 Schematic diagram of the RAS in the lung showing the role of ACE2 as a key element in the counter-regulatory axis of the RAS (elements in green; reviewed in Arendse et al.) 1636 7113 59272 545 6868 PMC7184931__F1 This schematic diagram shows the metabolic pathways controlling activation and lineage specification in the immune system 3716 3717 6774 50943 5867 7436 3949 948 960 6509 6510 196 405 4693 2539 920 PMC7186644__F1 Canonical Wnt/Beta-catenin signaling depends on the control of Beta-catenin degradation and translocation to the nucleus to activate target genes transcription 999 4040 4041 22943 324 1499 4609 595 442917 PMC7188081__F1 Advanced Glycation End Products: Building on the Concept of the “Common Soil” in Metabolic Disease 3667 1729 2932 PMC7189101__F10 Proposed model showing the connecting link between AKT and MASTL signaling during mitosis 84930 2029 983 PMC7190223__F1 Components of canonical hippo signaling pathway 60485 4485 9113 26524 PMC7191280__F1 SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications 59272 3458 545 7113 6868 PMC7192953__F6 Interregulation of the PIKK family members DNA-PKcs and ATM and their downstream substrates in the DDR pathway activated following DSB induction by IR 3091 472 9978 5347 3014 3981 PMC7196371__F9 Functions of HT in AD 9817 3717 6774 PMC7196612__F3 Oncogenic properties of Bacteroides (B.) fragilis 999 6774 1499 PMC7197376__F1 Manipulating a tumour suppressor 1021 1019 1017 6657 8091 PMC7197780__F1 Effect of ovarian stimulation on the expression of piRNA pathway proteins 122402 56165 84944 154197 PMC7198026__F2 Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges 6714 6774 8195 5292 596 993 PMC7198187__F1 Immunomodulation in COVID-19 59272 3662 201633 4513 7099 4615 3383 6347 367 10379 6773 6772 6774 PMC7200761__F7 Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R 673 8520 3480 PMC7202281__F5 Interaction network of differentially expressed proteins between patients with pancreatic cancer and healthy controls, assessed by the Ingenuity Pathway Analysis software 2324 7425 2266 2022 472 7040 7153 367 3543 3930 317 3487 10376 6277 10131 PMC7203449__F4 Visualization of Gene Ontology (GO) enrichment profiles from DEGs using Cytoscape software based on network analysis of ClueGO/CluePedia inferred from MCODE cluster 1 (A) and cluster 2 (B) 219972 5601 1356 7422 324 6241 4689 207 1111 4082 1876 7298 1021 2534 144455 PMC7204005__F5 miRNA promotes signal transduction and glucose protein binding through the TGF-beta signaling pathway and participates in the regulation of diabetes 7939 2885 331 10454 4091 4092 4087 4088 387 4089 999 6497 1386 PMC7204633__F2 Hypoxia driven interaction network that links CHI3L1 and TNFRSF12A to thyroid cancer 1116 51330 213 596 5747 3630 2934 4318 7422 PMC7205878__F2 Autophagy and microbial pathogenesis 102 55054 9140 9474 197259 PMC7206068__F3 TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses 3458 10155 117854 10626 6737 10346 57093 51127 8408 4591 60673 9776 7189 22954 286827 7942 201292 55626 PMC7207242__F1 Complement activation pathways and viral evasion of the complement cascade 717 720 1356 718 1604 7415 727 735 966 PMC7211126__F1 Schematic depiction of PD-related genes associated with different autophagy pathways 65018 5071 6622 120892 11315 25793 55737 54832 PMC7215987__F1 Phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway 5163 5728 3667 6009 7249 7248 2475 64798 253260 1977 PMC7216002__F1 Heme biosynthesis pathway (left) and the principle of HAL mediated PpIX production enhancement with dimethylsulphoxide (DMSO) or deferoxamine mesylate salt (DFO) (right) 2235 3034 23456 54977 210 5498 7390 3145 9429 7389 10058 PMC7216265__F3 lncRNAs affect glutaminolysis pathway in cancer 55000 23410 4967 100316868 2744 652995 100124700 114915 4199 4200 729082 101805488 PMC7216742__F3 Fyn signaling pathway 2534 6774 22863 8408 PMC7224208__F8 Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues 3458 6772 3665 22937 6721 7350 4609 468 3661 PMC7226441__F2 Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors 1000 999 3091 7852 6774 6935 324 PMC7226813__F2 JNK regulation of cell cycle progression, cell adhesion, and cell apoptosis 8717 7186 572 581 3725 2353 637 595 4318 PMC7226813__F4 JNK enhances fibrosis via crosstalk with TGFB, PDGF, STAT3, and WNT signaling pathways 3569 4087 4088 6774 1499 2353 3725 4312 PMC7226813__F5 Differential roles of JNK1 and JNK2 in skin cancers 6469 10892 1540 1386 3725 2353 PMC7226887__F1 Role of PTEN in the control of cell signaling 5728 572 23411 355 PMC7231083__F3 Evasion and inhibition of respiratory virus-induced IFN-I signaling 7099 7297 6773 57762 57506 51311 51284 7098 114609 3661 4615 PMC7232513__F2 Interplay between virus-induced cellular aggregates and inclusions 83939 468 2000 27161 PMC7237878__F1 Possible associations of the renin-angiotensin system with SARS-CoV-2 infection and lung injury caused by SARS-CoV-2 59272 1636 367 7113 6868 PMC7242157__F1 Metabolic, renal and neural health are impacted by a ketogenic diet 114548 2475 84699 5465 26291 59272 PMC7242206__F2 Possible targets of the androgen pathway for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylaxis and adjuvant therapy 367 59272 1636 7113 PMC7243914__F5 Immune signaling responses occurring in chickens infected with Salmonella 7099 8321 1499 114609 10392 7189 4088 64170 10454 5606 6416 PMC7246017__F3 Complement activation and vasculopathy in coronavirus disease 2019 (COVID-19) 727 59272 3383 7450 PMC7246647__F1 Fibroblast Growth Factor Receptor (FGFR) structure, ligand binding and signaling 3535 2885 7083 2549 7084 PMC7248369__F7 Integration of transcriptomic and metabolomic data 3931 23498 6567 252969 340024 4609 51056 57530 5925 3248 2194 1471 2548 1269 2878 6241 107 10606 7298 586 PMC7252450__F4 Advances in circular RNAs and their role in glioma (Review) 4784 4318 664613 1499 3217 494328 1019 3075 494334 4907 5266 6659 4858 10643 724024 10114 6928 6774 8324 1017 724031 1956 146057 693223 PMC7254625__F1 Pathogenesis of non-hereditary brain arteriovenous malformation and therapeutic implications 2050 5921 673 3845 3265 2475 PMC7254954__F7 PLAG-induced TXNIP and MMP-9 expression in breast cancer cells 1950 1956 10628 867 2060 PMC7257216__F8 Schematic diagram illustrating the mechanism by which asiaticoside inhibited MMT and ROS generation 7040 4087 4088 4089 PMC7260686__F5 Herb-target-signaling pathway interaction network 4609 5228 1956 10000 7481 2535 7422 7424 650 3265 3569 7015 8324 3162 2885 652 867 4149 5727 613 2353 7048 5925 7473 367 PMC7261627__F2 New insights into progesterone receptor signaling in the endometrium required for embryo implantation 1956 650 5241 64321 54361 6608 2624 9464 65125 2308 4582 PMC7263055__F2 Establishment of type 2 inflammation in ECRS 11005 85480 64806 90865 4035 3704 6356 PMC7266940__F3 Deeply characterized cellular processes affected by miRNAs in MB 6469 6608 2475 1021 3280 PMC7268158__F2 The JAK/STAT system in graft-versus-host disease 355 6373 920 3146 3717 114548 3458 1438 1439 2833 27022 PMC7272282__F1 PI3K pathway 5163 7249 7248 5728 1977 5266 8821 PMC7272282__F3 Crosstalk between PI3K signaling and DNA damage repair pathways 675 672 2177 472 27338 56946 5888 PMC7273095__F1 Androgen sensitivity gateway to COVID‐19 disease severity 367 7113 59272 1636 367 59272 1636 7113 PMC7276919__F1 DNA Sensing in the Innate Immune Response 54106 9474 7187 4615 3665 7189 3659 3654 51135 PMC7276919__F2 cGAS/STING pathway, a major cytosolic dsDNA sensing pathway mediating type I IFN signalingcGAS is localized close to the plasma membrane 115004 9474 29110 3661 PMC7277693__F6 Upregulated genes (red boxes) related to ER-stress and leading to apoptosis and protein degradation 7184 51726 10956 56605 27102 9709 1965 7186 83939 3310 468 7494 5609 1649 596 PMC7279047__F1 Aryl hydrocarbon receptor (AhR) signaling pathway 196 9049 405 57491 1545 1544 PMC7280757__F3 Complement Membrane Attack Complex 5970 5971 114548 79792 6364 6352 3383 7412 79038 64750 920 3603 PMC7280878__F4 Target genes and pathways of COL-3 and CGP-60474 in treating lung injury in COVID-19 2113 5062 1019 9184 7531 2931 5608 7534 602 3106 3107 2791 3105 6643 3303 387 998 7408 355 7454 3725 598 1981 2316 6347 4314 1108 5880 7124 5216 2353 811 1072 4323 8874 5829 PMC7281705__F3 Ang1 and Ang2 bind to Tie2 with similar affinities; however, whereas Ang1 is an agonist, the ability of Ang2 to activate Tie2 appears to depend on the cell type and context 6319 7075 1950 2885 2886 387 5879 5058 PMC7283464__F2 Enteroviruses regulate apoptosis through the PI3K/AKT pathway 581 4193 572 PMC7289712__F6 KEGG relationship network diagram 4846 3553 6647 3565 6347 3569 PMC7290655__F6 In PI3K-Akt signaling pathway (KEGG ID: hsa04151), various PKs and PPCPs are involved in translating the extracellular stimuli into phosphorylation signals and propagating these signals into downstream pathways 1956 3643 2260 5295 3667 6464 2885 207 5894 2932 1027 9882 572 7249 7534 2810 7529 7532 7531 7533 PMC7290974__F1 Toll-like receptors (TLR) and nucleotide-binding domain and leucine-rich repeat (NLR) receptor signaling in response to L 7097 4615 7189 10392 64127 7098 8767 3454 3455 3661 3665 PMC7291251__F1 Upstream and downstream mTORC1 signaling 7249 7248 51256 6009 64798 2475 64223 8408 PMC7291661__F2 Proinflammatory cytokines regulating keratinocytes or stem cells 9618 1499 6774 PMC7294267__F1 Three mechanisms suggested for the effects of statins and ACEis/ARBs in preventing severe pulmonary disease in COVID-19 59272 284 285 4615 2308 PMC7294406__F6 Cholesterol biosynthesis—a pathway that was up-regulated in OSA subjects treated with CPAP 39 10682 1717 3156 4598 4597 2224 51478 6713 4047 50814 1595 7108 6307 PMC7294914__F7 Proposed mechanism by which melatonin protects human renal proximal tubule epithelial cells against high glucose-induced fibrosis through the upregulation of PrPC 4087 4092 1009 999 PMC7296212__F6 Mechanism of NRF2 activation by oxidative stress 8452 9978 9817 PMC7296543__F1 Canonical signaling pathway of TLRs 929 7096 7097 7099 3929 10333 4615 114609 51284 51311 7098 54106 7189 7187 3665 29110 3661 PMC7297132__F1 Characteristics of astrocyte senescence 2670 3146 4035 3014 3569 4312 4803 3479 PMC7300907__F10 Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection 59272 57506 7098 29110 3661 3455 6772 6773 10379 3716 3454 7297 6774 PMC7306218__F4 Identification of hydatidosis-related modules and key regulatory genes 4570 2100 79923 4838 1191 2099 9573 7366 PMC7307829__F5 Analysis of TLK1 interactome and hypothetical pathway 2534 5829 207 7316 998 5880 1017 6790 9874 891 5347 983 595 PMC7308494__F1 RIPK3 and TGFB1 7099 3553 11035 8737 114548 197259 PMC7311766__F2 DAMP/PAMP PPR pathway manipulation 4118 4615 6850 9815 114548 2932 3659 3663 54472 PMC7311964__F1 Wnt pathway drug targets 6422 23184 324 1499 PMC7311998__F5 Molecular mechanisms of ID1-mediated BMP signaling pathway to control GLP-1 secretion in GLUTag cells 652 659 4086 4090 4093 3397 PMC7312833__F1 Toll-like receptors (TLRs) signaling pathway 3146 3553 7099 3554 7098 7189 7187 29110 3661 7124 PMC7312833__F3 Tumor necrosis factor A (TNFA)/TNFR1 signaling pathway 8737 7186 3553 PMC7313746__F4 Signature genes associated with immunological non-responsiveness to anti-retroviral therapy in HIV-1 subtype-c infection 54962 5965 64105 8914 2932 10949 4193 6124 6189 6304 6170 6210 7316 3688 54543 3676 1832 6229 3655 PMC7314952__F3 Ferroptosis, NRF2/antioxidant response element (ARE)–GPX4 pathway 9817 2879 23657 PMC7316884__F1 De novo ceramide synthesis pathway and its hormonal regulators in adipose tissue 2531 7124 253782 29956 204219 10715 79603 91012 7099 PMC7317062__F1 Neurofibromin is a negative RAS regulator 1956 3716 7297 4771 9113 26524 4763 2475 PMC7321691__F1 RT activates the IFNs-JAK/STAT1 pathway in cancer cells 3458 3716 7297 3717 6772 6773 10379 574031 24138 10561 3434 3659 4599 217 5359 3627 55601 3433 8519 226 11274 3725 4283 4938 2353 4600 2023 2027 2026 2019 2020 3437 3429 PMC7322029__F7 Cartoon comparing canonical Hippo signaling with signaling by Legionella LegK7 4485 9113 10413 PMC7322088__F7 Enhancing tumor growth due to the Hippo pathway being interrupted by LATS2 O-GlcNAcylation 4771 8473 26524 PMC7330112__F1 B-cell receptor (BCR) signaling pathway and BCR inhibitors 930 613 4067 695 2475 6850 5336 29760 596 PMC7330112__F5 Resistance-associated BTK (C481) mutation and possibilities of its overcoming in ibrutinib-treated CLL patients 930 613 4067 695 6850 5336 29760 2475 596 PMC7331746__F3 Essential functions of mitochondrial dynamics in immune cells 3458 9927 958 3566 9332 3659 PMC7331746__F4 Essential functions of mitochondrial dynamics in immune cells 100302155 929 638 5132 9927 2475 7124 11035 PMC7332729__F5 Influence of MCR on critical signaling pathways involved in embryonic myogenesis 994 4854 182 55664 8323 9759 8728 7422 54567 5294 26750 7477 4171 4616 649 3955 269 10209 55534 991 25 1869 144455 168667 221527 8841 113878 1967 8888 113791 1857 1019 3516 1021 9253 4087 51343 3480 3488 1965 9669 10912 7472 5287 659 1871 8453 25906 9775 4172 8408 9706 23533 6196 PMC7333666__F1 Simple overview of the Hippo signaling pathway and YAP 4485 60485 4771 9113 26524 2246 8829 7003 8463 7004 7005 2066 861 860 6910 PMC7333666__F3 Role of YAP in the cytoplasm and nucleus regarding central nervous system disease 5163 4485 2066 4771 7003 8463 6774 8835 6776 PMC7336380__F1 TLR signaling and domain organization of TLR8 81793 122769 7099 7096 7097 10333 7100 4615 114609 54106 51284 51311 7189 7098 7187 3665 3661 PMC7336871__F2 Physical approximation of APP and BACE-1 - a key event in Alzheimer’s disease pathogenesis 81609 29907 8650 274 23557 23163 8723 8678 23607 55690 351 23621 PMC7338604__F1 Wnt/Beta-catenin signaling pathway 999 1499 324 PMC7339600__F6 miRNA-TF-target regulatory network 4190 1543 8829 3815 367 2805 7422 1284 5465 1160 2251 187 1282 PMC7341754__F6 Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets 324 1499 3172 1050 4953 PMC7348939__F2 Possible molecular mechanisms of cellular senescence in skeletal muscle cells 89780 3491 4088 1017 1019 PMC7350257__F2 PI3K-AKT-mTOR and RAS/MAPK pathway crosstalk can contribute to mTORC1 and AKT inhibitor resistance 3667 4193 572 2932 8408 6446 2064 PMC7350758__F1 Vital signaling pathways and important substrates for downstream regulation of USP4 1499 7375 51701 3066 6925 7186 4089 PMC7352439__F2 Metabolic characteristics of M1 and M2 macrophages 3565 3596 6778 3091 355 3569 PMC7352479__F3 Crosstalk among glycolysis, MAPK, and PI3K pathways 5728 572 581 4193 3939 2597 5211 2539 PMC7352732__F2 Ferroptosis is the result of an accumulation of lipid reactive species 10146 23657 6520 444 2879 5625 PMC7352956__F3 Regulation of the Hippo/YAP signaling pathway in non-small-cell lung cancer (NSCLC) 1950 1956 5727 6608 1499 4771 4485 9113 26524 PMC7356240__F1 Macrophage migration inhibitory factor (MIF) mediates immune response crosstalk in dengue pathogenesis 4282 4318 972 960 3579 7852 PMC7363821__F1 High temperature- and cortisol-induced changes in gene expression 140805 5465 3158 5360 4199 7350 PMC7364557__F1 Model for ABeta-induced neurotoxicity and glial response in AD 4035 348 961 846 6850 54209 948 361 2043 2048 2534 7099 10288 351 PMC7364809__F2 Signaling pathway of SGK1 in oncology 367 5163 6667 10397 5902 6446 7249 2625 3726 4255 2932 6009 4193 2308 1499 149233 50943 PMC7366241__F1 Non-coding RNA in GC 999 5728 150209 100302276 85407 8091 57291 1499 2638 51506 389421 PMC7367493__F1 TLR and RLR signaling pathways 3454 7187 29110 3455 3716 51311 7098 51284 3661 8737 3665 51135 3656 3654 7189 4615 3663 7706 85364 201292 57506 PMC7367493__F2 RNA sensing and regulatory roles of NLRs 79671 84166 7284 9474 9140 55054 54941 7706 91662 57506 64127 338323 171389 1665 3661 3553 114548 1660 338321 79792 PMC7368652__F2 GSK3B on myocarditis and dilated cardiomyopathy 6279 6280 114548 3553 3146 1499 4318 PMC7369353__F1 Main mechanisms of Wnt/Beta-catenin and PI3K/AKT/mTORC1 pathway interconnections 7249 4040 4041 324 8312 2932 595 8313 6925 64798 1977 PMC7369811__F7 Scheme of the potential IR-induced EGFR/NFKB–RIP1–Src–STAT3–EMT pathway 1956 6714 6774 PMC7369945__F1 Androgen “backdoor” steroidogenesis pathway 1586 3284 1589 1584 8630 3290 3293 8644 PMC7372134__F3 HO-1 dysregulation in cystic fibrosis (CF) 3091 857 4094 2932 PMC7372205__F1 ACE2/TMPRSS2 pathway and its interaction with SARS-CoV-2 59272 7113 367 6868 PMC7372205__F2 COVID-19 early stage pharmacologic intervention targeting Sars-CoV-2 cell entry through the ACE2/TMPRSS2 pathway 7113 59272 367 6868 PMC7372882__F7 PI3K-AKT signaling pathway plays a central role in anti-TAO system of SP 2885 7422 5595 3630 3643 1950 356 355 843 840 3667 598 5728 572 596 5879 3558 4170 4117 7124 5743 3691 2920 4193 PMC7375892__F5 Affected Local Networks by RB1 and TP53 Inactivation Events 11130 10403 8438 83540 79980 55143 4001 6790 5888 1058 23468 2237 7283 699 9055 7027 9212 641 1111 6789 991 5925 5347 2146 4436 3066 983 701 55723 1786 2177 898 672 1026 1017 1031 8317 4171 1869 2176 8208 79075 5111 3065 9611 115106 4605 595 5429 81620 6714 23397 1789 4172 5422 1029 2956 9522 5984 1643 5777 4193 891 2874 5788 1956 3308 900 51053 355 695 4851 6135 9134 7398 6117 6154 3932 801 4175 6122 5557 6850 5426 7535 5982 3635 PMC7378646__F1 Overview of Hippo-YAP1/TAZ pathway and its role in cardiac biology 4485 9113 26524 10413 PMC7379175__F8 Model depicting the relationship between CIBZ, RB1CC1 and autophagy 9821 9776 8408 60673 PMC7380956__F1 Accessory pathways of glucose metabolism: 79147 1605 2539 26227 PMC7381294__F6 Differentially methylated genes enriched in the adipocytokine signaling pathway 9021 3953 6774 5465 9370 PMC7382369__F4 Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS 7249 7248 790 1723 7372 PMC7382586__F1 Regulatory mechanisms of linc-ROR in breast cancer 100885779 1849 382 6935 9839 4087 PMC7383626__F1 Non–small cell lung cancer tumorigenesis pathways and mutation frequencies are illustrated 1956 238 5979 2261 6098 4914 4763 3845 5290 5728 673 207 PMC7384693__F2 Overlapping Networks and Selection of Network #7 for Further Analysis 3880 3875 2810 51512 10038 7832 3164 9212 11335 6427 10014 699 2067 PMC7387173__F3 Segregation of acute activity and cell transcriptional gene expression in POMC and NPY/AgRP cells 3953 3643 2693 7224 4852 181 5091 5443 PMC7387468__F3 piRNAs related to the epigenetic control of pathways involved in vesicles transport, phagocytosis, demyelination, apoptosis, inflammation, loss of sensation, and pain are differentially expressed in leprosy patient (LP) 1850 2738 6522 2677 775 2621 400506 79800 2120 107048980 134829 6506 7301 9528 56659 841 6549 4842 22987 957 836 2767 2773 388336 7442 50615 149233 3785 3756 PMC7391798__F2 Autophagy PCR chip and KEGG PATHWAY database analysis 468 55669 9927 84749 10133 55626 9101 4077 4286 7030 51024 192111 664 6667 PMC7392137__F1 The original model for Wg signaling in Drosophila, the core of the current model for the canonical Wnt signal transduction (the Wnt/Beta-Catenin pathway) 4041 4040 474168 1499 2932 324 4827 8178 PMC7392137__F2 Two well-known non-canonical Wnt signalling pathways, including Wnt/Ca2+ (right) and Wnt/PCP (left) 4920 6259 4919 5879 23002 3725 387 PMC7393266__F2 Major anti-tumor mechanisms of EGFR monoclonal antibodies 1956 1017 7018 581 3014 PMC7397204__F2 PI3K/Akt/mTOR signaling and its interaction with PTEN 3667 3716 5728 5888 5163 79172 7249 7248 4193 572 1017 PMC7397304__F6 Possible antioxidant signaling pathways regulating dexamethasone-induced muscle apoptosis by quercetin 581 572 2308 4087 PMC7397661__F3 Interrelated regulatory of CircRNA and EMT 1499 693184 8091 55740 208 1000 999 PMC7398577__F2 Viral miR-mediated suppression of host innate immune pathways 3556 7099 10333 7097 7096 7098 7187 51135 6774 54106 3654 3656 29110 7189 51311 51284 57506 23118 257397 3661 3665 9021 4615 114609 929 3570 PMC7398577__F3 Viral miR-mediated evasion of adaptive immune responses 920 4277 100507436 1508 10437 6352 51752 6373 PMC7401609__F3 Fat metabolism in the subcutaneous fat of yaks under long-term energy stress (ES) 7038 364 3569 3952 79993 3991 57104 60481 3992 23305 10005 28976 8310 2181 PMC7401609__F4 Energy balance in yaks under ES by regulating fat metabolism 3952 5209 10005 8310 5210 260402 2475 28976 6720 6517 PMC7403894__F3 Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies 7096 7097 10333 7099 4615 3654 59272 3553 7187 51311 51284 3297 2932 114548 PMC7405053__F3 Possible mechanisms for PGE2 modulation of immune cell functions in COVID‐19 7113 59272 4615 3661 3665 4513 3458 3553 6347 114548 6774 6772 6773 920 50616 7124 PMC7407293__F1 Nuclear factor-kappaB (NF-kappaB) signaling pathway 958 613 5971 PMC7407594__F4 Posttranscriptional mechanisms by RNA-binding proteins (RBPs) regulating mRNA stability 7099 84433 8915 10892 5976 9683 10865 167227 23644 PMC7407660__F2 COP9 signalosome (CSN) partners with ubiquitin-specific protease 15 (USP15) and 48 (USP48) in the NFKB signaling pathway 6500 84196 8454 9958 8651 9978 8453 PMC7407942__F1 Schematic process of the autophagic pathway 1956 5728 4193 7249 7248 6009 7942 8408 9706 83734 664 9140 665 9474 143686 10533 7405 22863 55823 57617 PMC7408018__F1 Autophagy pathway including the convergence of the endocytic pathway 2475 8408 55054 9776 9821 9140 60673 22863 5289 30849 3920 PMC7408280__F3 Transcriptional modulation of the inflammatory response in PD 7054 3553 3569 4513 4094 PMC7409273__F7 Proposed model of signaling pathways involved in HPV16 E7-mediated Pirin upregulation in oral epithelial cells 1956 207 8544 PMC7409344__F3 eIF4B can stimulate eIF4A 1499 1977 1975 PMC7411263__F6 Hypoxia-related signaling pathways enriched by target genes of DE miRNAs in different tissues, including (A) the HIF-1 signaling pathway in heart, and the insulin signaling pathway in (B) muscle and (C) liver 7037 5335 815 5336 818 3098 2321 5105 5106 5266 10000 2308 5170 5291 2203 92579 2998 5257 PMC7411263__F7 Genes targeted by DE miRNAs enriched in the downstream of p53 signaling pathway 50484 894 1021 PMC7412373__F1 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways 5728 10682 7099 1499 847 324 4094 55553 PMC7412373__F3 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways 1875 355 51701 9474 2475 1848 1847 26191 5728 969 PMC7426442__F3 SARS-CoV-mediated evasion of host innate immune response 59272 3661 6773 PMC7427779__F8 Schematic summary of this study 1997 5879 25816 PMC7427806__F5 New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP 2597 7186 643 5971 2146 29851 PMC7429250__F3 Hypoxia-mediated glucose metabolism promotes dynamic O-GlcNAcylation of G6PD facilitating the utilization of PPP to produce NADPH for ROS detoxification 7428 5163 8473 2539 50507 PMC7429716__F1 G2/M checkpoint signaling pathway 545 993 7465 995 1017 983 PMC7432012__F4 Material stiffness-induced Wnt signaling 4040 4041 324 1499 PMC7433817__F6 Schematic chart of drug sensitivity‐related genes in the current study with proposed interaction or regulatory pathway in ccRCC 2475 558 116 5979 1487 2778 26020 898 84519 4193 PMC7435027__F4 Illustration of the effects of acetaminophen on glutathione, antioxidant processes, and metabolic processes 3418 4199 4522 3417 4200 PMC7438472__F2 Activation of the AIM2 inflammasome 9447 115004 79792 3553 834 3659 PMC7438569__F1 NAD+ metabolism in the heart 10135 952 64802 349565 23057 PMC7438931__F1 mTORC1 pathway and regulation 5163 7249 7248 2475 6009 64798 64223 8408 7942 PMC7442051__F1 Mechanism of autophagy 662 8408 2475 9140 9474 PMC7442608__F4 Folate cycle is coupled to the methionine cycle through distinct mechanisms 26227 29968 5723 6509 6472 441024 4397 4524 PMC7443001__F3 Localization of 38 DEGs in the MAPK signaling pathway 1147 4790 8517 2872 6197 5154 2885 2005 4609 673 9965 2264 1848 5922 11221 5532 6788 409 8717 7186 2353 1616 5494 355 208 2122 10912 7157 7189 4208 PMC7445530__F1 Regulatory mechanisms of BLACAT1 on proliferation, invasion, metastasis, tumor cell cycle control, apoptosis, autophagy, and chemoresistance in multiple human cancers 101669762 2146 999 1499 7408 729230 10533 5243 6774 23512 1000 4318 4313 PMC7449905__F4 PAK1 is a key molecular determinant in major cell proliferation pathways 5058 1499 1956 1950 5879 2475 4609 51176 3725 PMC7449905__F7 PAK1 in autophagy pathways 5058 9474 2475 8408 60673 9140 5289 8878 2309 PMC7456827__F1 Circadian regulation of complement immune system 718 717 8863 8864 1407 1408 9575 406 1628 4783 6095 PMC7458397__F6 p85 roles (p110 dependent and independent) in the insulin response 3479 5728 3667 998 2932 PMC7460564__F3 Enzymatic activity of prolidase affects various cellular processes 5184 2475 5625 29920 PMC7460640__F3 Sex-related signaling pathways in aortic valve fibro-calcification 4256 4087 4088 650 6772 860 718 PMC7464279__F7 Synergistic effect of cyclopamine and rapamycin 6608 51684 2735 2736 2737 PMC7465197__F2 Number of transcriptional factors positively or negatively regulate ARF transcription 4609 1870 1869 4087 4088 6909 2146 1956 648 23492 PMC7465203__F1 The Wnt pathway 324 1499 4040 4041 PMC7468432__F1 Development and differentiation of Breg cells 10113 952 930 100133941 960 7852 PMC7468493__F1 The signal transduction pathways associated with epithelial–mesenchymal transition (EMT) 648 132864 999 221937 6935 6597 55203 7124 1499 1000 1950 3082 PMC7468567__F4 Target genes and pathways of COL-3 and CGP-60474 in treating lung injury in COVID-19 3107 3105 3106 6347 5216 6643 11311 3303 7879 3561 598 832 9175 1072 3725 7454 5897 811 998 2353 7408 5829 7124 355 PMC7471374__F2 Upstream and downstream pathways of CARD9 7097 7099 6850 3654 51135 7186 64170 7189 8915 4615 PMC7472741__F2 SREBP-regulated mevalonate pathway and its regulation 3652 4598 10654 387 6713 4047 7108 50814 51478 5978 10682 6309 1717 3949 PMC7477886__F4 Whole network from APOE genotype to AD constructed from KEGG-based Alzheimer’s disease pathway 10313 23621 2776 5331 3709 824 348 4842 775 808 5532 572 54205 842 836 102 7132 8772 841 637 PMC7479251__F7 TLRs pathway including targets and drugs that could be employed to inhibit it 4615 7096 7097 10333 7099 7100 51284 51311 54106 7098 51135 7189 3654 7187 23118 10454 3665 3663 29110 3661 PMC7481593__F2 Ferroptosis modulation in tumor 9817 3658 4495 2495 5261 55847 2879 6520 23657 PMC7481617__F1 Estrogen receptor (ER) and pan-HER signaling inhibition has synergistic activity and leads to gene expression changes associated with good prognosis in non-small cell lung cancer (NSCLC) 374 1950 1956 51523 5241 3725 2353 8190 2886 2296 PMC7482807__F4 LncRNAs-regulated resistance to targeted therapies beyond HER2 5728 101805488 1019 595 1021 378938 338799 11140 1017 23239 11191 8841 7503 23013 2146 1869 PMC7484659__F3 Schematic model illustrates the neuroprotective effects of THSG on STS-induced toxicity by restoring BNDF-TrkB/Akt signaling axis and inhibiting apoptosis 627 412 440514 PMC7488362__F2 Diagram depicting the mechanism of CR involving multiple signaling pathways 1839 9846 6714 6010 4087 4088 324 1499 6093 9475 2475 5728 960 1956 4851 PMC7492390__F2 Immunological basis of TCMR 324 920 2833 4283 3627 3458 PMC7493230__F4 Proposed mechanism for the EGFR/c-Met-mTOR/S6K signaling axis in NSCLC 3082 1950 4041 7249 6009 1499 1977 6194 7465 8061 1956 PMC7494507__F2 Regulatory mechanisms of CD47 expression.Regulators of CD47 expression in cancer cells includes cytokines, oncogenes, microRNAs as well as enzymes 3603 140885 961 4609 54814 6774 PMC7494613__F8 H3K27M mutations are dependent on a critical metabolic pathway also used by mIDH1 to regulate global H3K27me3 levels 2146 7403 23135 3417 3099 PMC7497304__F1 Models for the interactions between tumor cells and the tumor microenvironment in the brain 6774 7124 729230 5728 6347 1435 1493 PMC7499294__F2 ER stress-induced inflammation in macrophages and ECs 22926 7186 83939 468 10628 114548 PMC7501082__F2 Involvement of host and viral proteases in SARS-CoV-2 life cycle 59272 5045 7113 PMC7503882__F2 Molecular pathogenic signaling pathways in ACM 4771 2932 4087 4088 4485 1499 4089 9113 26524 4040 4041 PMC7504526__F4 mtDNA-triggered cGAS-YAP pathway 115004 9113 29110 10413 PMC7505114__F3 IVM-induced PAK1/Akt/mTOR-mediated autophagy.IVM promotes degradation of PAK1 by ubiquitination/proteasome pathway, thereby inhibiting the Akt/mTOR signaling pathway 5058 718 5289 22863 2475 PMC7507029__EV5 Graphical summary of LRP6‐YAP signaling pathway 4040 8473 9113 26524 4485 PMC7512049__F8 Key network of “drug-component-target-biological process- signaling pathway” (P < 0.05) 1636 6774 1956 4353 598 2147 2358 624 836 PMC7513295__F4 PPI network analysis 7711 1512 3108 4049 7638 80778 1147 29108 6095 7006 100124696 7766 114836 57823 10538 634 79465 1880 51561 330 3718 149233 6504 962 64167 7037 84868 29126 7128 5788 54440 6693 9641 941 11006 3109 7099 4938 3119 6772 4939 64092 973 3115 6850 970 81622 55824 6672 7294 PMC7513516__F1 Domain structure and signaling pathway of STAT3 8651 6714 1636 4200 6774 941 942 3627 7124 4313 7291 4170 4609 3091 10401 100302213 100302167 100847014 5820 102800310 388796 503637 PMC7513951__F3 MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment 6925 2932 595 4609 PMC7516134__F1 Zoledronic acid on the bone metastatic niche and the “vicious cycle of bone metastases” 3569 3570 3553 7852 6387 PMC7519203__F2 Proposed mechanisms and time course of SARS-CoV-2 infection when using a ketone-based metabolic therapy 59272 2309 2308 3661 5166 5163 3091 7054 PMC7519203__F8 Proinflammatory signaling that occurs during viral infection and mechanisms through which R-BHB inhibits this signaling 4615 3654 8772 57506 64127 10628 5763 114548 51311 51284 7189 8473 6774 619537 3661 PMC7520283__F1 MiRNAs involved in OA‐FLS inflammation 2475 2309 6667 3553 6347 PMC7520695__F3 Signaling pathway of IL-1B and IL-18 3603 3556 3554 4615 7189 PMC7522204__F5 In silico analysis indicating an inhibitory effect of Ambrisentan on PAR2 signaling pathway 1956 2776 409 6714 100616294 9144 100302177 5241 PMC7522761__F2 Ingenuity Pathway Analysis of candidate genes downstream of interferon-alpha signaling from dermatomyositis skin analysis 282618 3665 3661 3663 6773 3659 6774 10379 6772 4609 80830 4939 9636 3627 91543 48 PMC7526653__F3 Cystathionine metabolic pathway 26227 29968 5723 6472 6470 875 1491 PMC7527410__F1 SARS-CoV-2 viral entry to host cell pathway 59272 6868 7113 PMC7528551__F2 Phosphatidylcholines constitute a major metabolic signature of VAT versus SAT 10400 1119 10390 56994 8540 PMC7528681__F1 WNT Signaling in Lung Repair and Regeneration 54894 84133 4040 4041 324 1499 5879 387 998 3725 51701 PMC7530006__F2 Schematic Indicating Common Pattern Recognition Receptor (PRR) Pathways Used by Immune Cells to Recognize Danger Signals 3553 115004 9447 114548 57506 29110 3661 2357 5879 6850 7100 7096 7097 10333 4615 54106 7099 79595 51311 51284 7098 PMC7538181__F3 Transcriptional regulation of memory B cell differentiation 613 3845 604 958 6497 7090 60468 1026 1029 2308 4609 867 3662 PMC7538784__F1 Current mechanisms proposed for metformin in pathological pain 10645 253430 7249 6009 3458 PMC7540116__F3 Metformin inhibiting cancer invasion and migration 4087 4088 6774 4089 2475 283120 378938 7249 4513 3383 8091 4609 PMC7540151__F3 EMT by miR-187 6659 4907 5753 9839 1601 6275 4087 PMC7541099__F3 Putative mechanisms of SARS-CoV-2 infection 7113 5045 59272 4615 51284 4318 PMC7544648__F1 Mechanisms of alcohol-induced microglial eCIRP in promoting AD pathology 7099 3146 3716 3717 6774 114548 1020 PMC7544739__F2 Interactive roles of SOCS1 and SOCS3 in TLR signaling 2621 7099 8205 4615 4118 8651 7098 7187 29110 7189 9021 6497 3665 3661 PMC7545984__F1 Anti-fibrotic roles of the GSK-3B signaling network in fibrosis 6446 23410 3611 2932 4088 1499 596 8678 999 2335 PMC7545984__F2 Pro-fibrotic roles of the GSK-3B signaling network in fibrosis 409 1499 2335 PMC7547764__F1 c-MET/HGF pathway in gastric cancer pathogenesis 3082 1956 2475 2885 2549 6714 PMC7547786__F2 Signaling pathways of IL-17A, pathological effect, and potential drug targets 84818 3717 7189 4513 3576 6374 2919 4314 4318 PMC7550420__F2 Process and regulation of STING trafficking 79065 8897 9110 81555 29886 29110 3661 PMC7550684__F3 Relationship between IL-17A and astrocytes 3553 574413 6774 9021 PMC7551260__F2 Antiviral immune response and evasion mechanism of coronaviruses 163702 7113 3588 59272 1803 7098 5355 51311 51284 57506 4615 7187 7189 29110 3659 3661 3665 7297 PMC7551521__F1 Immune responses induced by SARS-CoV-2 57506 29110 3661 PMC7552539__F5 Simplified examples of the roles that different classes of ceRNAs play in HCC oncogenesis 728655 442917 5567 6935 23326 23411 50807 387 PMC7553088__F5 Chemokine-like factor 1: A promising therapeutic target in human diseases 1233 595 4609 6774 619501 PMC7553635__F6 Activating Wnt and inhibiting Hippo pathway by cytosolic PWP1 11137 1856 4485 1499 9113 6925 595 4316 PMC7553876__F1 Hypothetical mechanism by which SARS-CoV-2 successfully evade the immune system while maintaining an inflammatory feedback loop 7113 59272 6868 3553 6348 PMC7554191__F9 Mechanism of EMAP II/ S1P signaling and modulation of S1P homeostasis 1958 8877 53637 1901 1903 8698 9294 PMC7554875__F1 NFKB and MAPK pathways 6668 4615 7124 51135 3654 PMC7554980__F2 mRNA in vitro transcription and innate immunity activation 7098 23586 51311 51284 4615 57506 920 3665 83939 6041 PMC7555004__F3 Some proposed mechanisms of aging involving xanthine oxidoreductase (XOR) and its products 23411 2475 983 472 3553 114548 PMC7555140__F1 Small heat shock proteins (sHSPs) regulate apoptosis in the extrinsic and intrinsic apoptotic pathways 8772 836 331 3315 PMC7555423__F7 G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells 2852 595 898 1021 1017 PMC7555571__F1 AHR signaling pathway 196 6714 9049 405 57491 1545 PMC7555743__F7 Schematic diagram showing the signaling pathways involved in anti-inflammatory effects of the combination of ginsenosides Rg2 and Rh1 in macrophages 6772 3553 7099 PMC7555965__F4 Molecular pathways involved in aCML 7054 3717 2782 6774 6418 207 4193 23133 2475 10188 26040 5163 PMC7560597__F5 Complexity of interactions between autophagy machinery and the cGAS–STING pathway 115004 8408 26100 3661 29110 PMC7560826__F1 Janus-like role of proline metabolism in cancer 5831 29920 5625 65263 4942 PMC7560826__F4 Janus-like role of proline metabolism in cancer 581 5625 8772 317 29920 65263 PMC7560959__F7 Proposed metabolic pathway illustrating OTA nephrotoxicity 9817 8452 2950 PMC7563518__F1 Metabolic pathways of l-tryptophan (a) and l-arginine (b) 6999 169355 3620 4843 435 4846 4942 10993 6611 PMC7564143__F4 Simplified overview of the classic Hippo-YAP signaling pathway 4771 60485 4485 9113 26524 154796 1499 PMC7564205__F5 NRP1-ABCB8 pathway: Schematic representation of the NRP1-ABCB8 pathway in regulating iron homeostasis, iron-dependent oxidative stress, mitochondrial function and cellular senescence 11194 3383 7412 2242 8829 PMC7564391__F5 Major lncRNAs involved in taxane resistance 6935 1019 652995 283131 23235 100616180 1982 255812 596 388948 29931 PMC7565467__F2 Key components of the Ca2+signalling machinery in the control of cell proliferation and the cell cycle 23237 6786 5925 4609 3725 2353 84876 PMC7565554__F4 mTORC1 inhibits various steps of autophagy 7942 7030 8408 9776 22863 7405 60673 29982 55626 PMC7565808__F1 Micropeptides encoded by lncRNAs regulate tumor malignant behaviorsa Linc00998 encodes micropeptide SMIM30 promotes HCC development by inducing SRC/YES1 membrane anchoring and MAPK pathway activation 284276 643911 404266 3481 6774 671 6713 6194 440335 6671 PMC7567113__F8 BNip1-mediated apoptosis in photoreceptors 9554 100170220 662 596 581 8100 9371 53407 55850 PMC7568161__F1 Proposed pathway underlying rh-CSF1 provided neuroprotection 1435 5336 7351 PMC7568723__F6 Histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis 9810 3985 6093 10451 5217 6010 PMC7572682__F2 Lysosome and nucleus interaction in signaling and transcription 2309 5465 200186 7942 80317 PMC7573235__F3 Signaling pathways activated by AKT 3479 5728 3611 5292 11040 3667 7189 9188 PMC7573235__F4 Signaling pathways activated by AKT1(E17K) 3479 5728 5163 3611 5292 11040 3667 7189 9188 PMC7578381__F6 Functionally grouped network visualization for epigenetically upregulated and downregulated genes 6504 952 2327 83706 218 7456 5023 7130 196374 5788 3882 2799 125115 126014 51411 3101 11027 3850 51350 3902 3868 79865 151888 11187 1832 146722 9333 10288 3860 5493 PMC7579710__F6 Potential mechanisms of PB2‐induced apoptosis in OS cells 207 581 596 1362 PMC7582160__F4 Details of unfolded protein response activation in the venom gland 7494 2081 468 22937 5468 22926 7415 7186 3638 10130 811 5611 3312 7184 821 6720 84447 10956 10808 6721 51360 1649 8720 3313 596 3732 6400 267 10153 10294 83939 PMC7583738__F1 PTEN in the PI3K/Akt signaling pathway 5163 5728 2932 595 1975 PMC7583882__F1 Schematic summary of Sphingosine 1 Phosphate (S1P)/S1PR (G-protein-coupled receptor) agonist and antagonist signalling 56848 8877 6010 PMC7586277__F7 Pathway leading to phagocytosis of senescent AD-MSCs 929 7099 7097 114548 718 719 10628 834 727 3606 3603 PMC7586430__F2 Regulation and functions of NEDD4 E3 ligases in cardiac disease 2146 64750 7040 23327 11060 83737 4090 4086 10628 11059 890 891 4904 4092 PMC7589139__F5 The proposed molecular mechanism of glucose-6-phosphate dehydrogenase (G6PD) deficiency in human aortic endothelium and monocytes 2539 7124 3383 7412 PMC7590177__F1 Detection of poxviruses by anti-viral pattern recognition receptors (PRRs) leads to the activation of IRFs 2475 115004 54106 7098 51311 51284 57506 10010 9755 4615 7187 7189 7099 29110 3553 3661 PMC7591658__F6 BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes 9531 7415 26353 7917 PMC7594502__F2 Mitophagy pathways in health and disease 11331 10133 29110 139341 664 79671 PMC7595283__F1 Some like it hot: Candida activation of inflammasomes 1956 114548 58484 3553 6850 64170 PMC7596939__F3 MiRNA regulation in signaling processes in obesity, liver and uterine cancers 6850 4775 2324 10000 2783 7533 5519 4214 3455 3326 369 2872 55970 572 409 894 6722 3688 2316 23239 4791 3725 3912 PMC7600282__F4 Target points of the dietary compounds on mitochondrial dynamics and mitogenesis, with a particular focus on mitophagy 2309 2308 23410 2475 4899 7942 51024 7019 139341 57154 23770 10533 64422 55486 65018 PMC7600811__F13 Simplified representation of the Rho/ROCK signaling pathway 6010 5728 29109 PMC7601443__F3 Crosstalk between adipose tissue clock and important signaling targets 2475 28999 9575 10135 23411 PMC7601667__F2 Cross-link between EMT-induced signalling pathways and Autophagy-inducedsignalling pathways 1950 7039 1499 9839 999 PMC7603577__F10 TNF signaling pathway in the treatment of gout and hyperuricemia with plantain 840 8772 3569 7124 23118 257397 10454 7186 7188 8717 4318 4049 PMC7605163__F6 TGFB Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation 468 29968 5723 26227 PMC7609160__F1 Hippo Signal Transduction Mechanisms in T Cell Immunity 4485 9113 26524 81704 387 5872 4040 4041 2932 324 2308 1499 PMC7609400__F2 Extrinsic function of the PD-1/PD-L1 signaling axis in cancer 324 7535 3932 27040 3558 940 941 PMC7610307__F4 Tumor inhibitory role of GSK 3B 4282 5728 2932 595 999 1499 367 PMC7610648__F3 Replication-coupled ICL repair 55247 91442 199990 84464 PMC7611989__F2 TH effects on hepatic autophagy 5469 1374 8408 139341 10020 10645 PMC7641946__F1 DSB Repair Pathways 7518 5888 10721 56941 2237 7515 3980 PMC7641946__F2 Therapeutic Application of MMEJ for Cancer Treatment 10721 7465 545 PMC7646705__F1 Schematic outline of lipid oxidation and impaired lipoprotein metabolism in psoriasis 4015 5444 3931 9619 3949 PMC7649723__F1 SARS-CoV-2 replication 59272 7113 5478 PMC7651136__F4 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer 472 993 1017 545 7465 995 983 2305 PMC7651821__F2 Tumor progression by E3 ligases and DUBs 4193 4194 2194 595 999 673 324 6502 5728 1786 991 7874 23133 7186 7189 1540 2475 55294 9978 6500 8454 367 9097 2308 4092 10987 1869 2064 PMC7652848__F2 Aryl hydrocarbon receptor (AhR) signaling pathway and tryptophan-indoleamine 2,3-dioxygenase (IDO)-AhR axis 9049 196 405 PMC7653260__F3 Signalling pathway of autophagy in HL 2475 8408 9140 PMC7657570__F1 Androgens facilitate SARS-COV2 entry through a TMPRSS2-mediated pathway 367 1636 59272 7113 PMC7657662__F2 Schematic depicting the complex I assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded subunits underlined and assembly factors in italics 4695 4719 4723 4698 4720 4722 374291 4728 54968 55572 55471 2242 4729 55967 79133 284184 80224 4731 4726 4711 4707 4716 4712 54539 4538 91942 4724 25915 29078 4704 4705 4700 90871 4706 4535 4540 4536 4694 4709 4708 4714 4713 4715 4701 4537 4539 4541 4717 4718 4725 4710 4696 4702 51079 126328 137682 51300 28976 55744 51295 51103 55863 25880 PMC7657662__F6 Schematic depicting the complex V (F1F0-ATPase) assembly pathway showing known mitochondrial disease genes in red, mtDNA-encoded proteins underlined and assembly factors in italics 466 317 2147 1386 522 4508 4509 516 PMC7661519__F4 Gene pathway analysis of the co-expression and co-localization of mRNAs in this study 93343 25796 376497 100188949 105221694 3146 684 84705 79575 4553 129607 104326052 91543 9781 10561 142678 1397 4763 4017 2475 84064 6314 84515 257019 222229 80210 PMC7662528__F6 RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson’s Disease 6001 8772 7099 PMC7662933__F3 ErbB receptors and their signaling pathways 3084 9542 10718 145957 2885 2534 6714 5163 2475 2002 2066 2065 2064 PMC7662987__F5 Schematic display of antitumor activity of CUDC-907 hybrid drug against prostate cancer cells 4609 7465 6241 6240 PMC7663720__F2 Pharmacological inhibitors targeting the Wnt pathway that are currently being tested for cancer treatment 4040 4041 324 1499 607 PMC7663815__F11 Crosstalk between androgen and Notch signaling pathways in rodent Sertoli cells 2638 367 3280 23462 4851 PMC7664031__F7 Common altered signature as effect of multiple dose exposure to doxorubicine a Common altered up- and downregulated genes between P12 and P24 in Hs578T and MDA-MB-231 89932 114827 6236 8714 8743 2052 4599 1589 7124 PMC7666984__F1 TLR4 signaling pathway (schematic) 3929 929 7099 114609 4615 7189 3661 3665 8213 PMC7668396__F1 PI3K pathway 3815 5163 5728 7249 93999 595 6194 PMC7671546__F8 G ATA2 mediates the negative regulation of the prepro-thyrotropin-releasing hormone gene by liganded T3 receptor B2 in the rat hypothalamic paraventricular nucleus 3258 7200 3717 2624 6774 108348018 7252 PMC7671657__F1 PI3K signaling pathway 2308 1956 5728 7249 7248 5163 2997 PMC7673844__F1 Sources of serine 29968 5723 26227 6472 6470 PMC7675040__F4 Alteration in DNA repair mechanism in esophageal cells chronically treated with cigarette smoke condensate 5111 472 545 63967 11200 7161 51466 23269 5469 5591 8797 3981 23524 8812 2146 546 1017 PMC7675396__F4 Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation 7018 3553 7124 59272 7035 PMC7677084__F9 Network diagram of two pivotal pathways for muscle development in KEGG enrichment analysis 4208 9978 5581 80326 23236 894 5593 4772 51701 4775 51384 51176 5530 23439 85366 5997 147 25805 1855 4316 4638 PMC7678118__F5 PDGFRA/EGFR signaling activation and effects on RAS/MAPK pathway 2735 1950 7039 2885 6654 6714 PMC7685642__F1 MTOR signaling cascade 5728 253260 7249 7248 388 6010 2475 1977 PMC7686704__F2 Wnt–PCP signaling pathway in mammals 27152 27130 57216 9620 6259 4593 5754 5879 387 998 PMC7687355__F4 Predicted activation of VEGF signaling after both APAP300 and PHX 1579 51053 2289 221395 51129 84525 4175 57007 9212 4085 3158 3161 PMC7689594__F6 Sub-network of hub genes related to the disease phenotype of chronic ITP 3725 5568 9126 4000 PMC7690154__F1 MiRNA biogenesis and regulatory signaling pathways 5728 4092 4087 387 4088 4089 1874 693222 5901 29102 54487 PMC7694686__F1 Summary of MEMO1′s role in a variety of signaling pathways, including the: (A) ERBB-family, (B) FGFR-family, (C) IGF1R-family, (D) estrogen receptor and (E) PDGFR and S1P/S1PR families 3480 51072 6714 387 2932 324 23122 PMC7695248__F6 Sex-dependent metabolic and transcriptional changes after disrupted Cyp51 from cholesterol synthesis align with hepatocarcinogenesis in humans 9420 948 2645 2998 2950 5465 2690 1581 7536 7038 PMC7697260__F4 Differences between the ECM− and ID+ fibroblast clusters are largely replicated in PDF and JDF spheroids with distinct features present in PDF fibroblasts 64146 1278 1291 5159 1634 3397 10952 29927 1281 3309 9789 3624 1282 50509 PMC7697568__F3 Target therapies for ligand-dependent tumors 55366 8549 4040 4041 54894 324 PMC7697684__F7 Fatty acid synthesis and Akt-mediated regulation of lipid metabolism via phosphorylation of its targets and SREBP-dependent expression of various proteins (in light blue) 3949 355 47 PMC7699519__F1 The NRF2 pathway 9817 8452 9978 8454 6500 4094 3162 9588 2730 2729 2877 5052 7295 23657 10628 4199 5226 3417 2938 571 2946 2947 2940 2939 2944 2950 2948 22949 5693 5682 8878 PMC7699590__F2 Platelet-derived growth factorB (PDGFB)-activated pathways mediating vascular smooth muscle cell (VSMC) migration 5155 50507 5163 85451 2475 5058 PMC7699726__F2 KEAP1-NRF2 modulation in cancers such as RCCs 5546 7428 7249 7248 2475 9817 2271 3550 8454 2534 23411 25 673 3845 4609 PMC7701955__F2 Canonical and non‐canonical TGF‐B signaling 4087 4088 7189 9618 387 998 4089 5062 57154 4092 2475 920 50943 355 638 6662 10413 50507 PMC7703541__F2 Targeting the renin−angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges 185 59272 186 4142 116512 PMC7703729__F8 Proposed intracellular mechanism of GRP78 and protein kinase A (PKA) signaling pathway activation by vaspin on basal and IGF-1 and gonadotropin-induced steroid synthesis in ovarian cells 3973 2100 1583 6770 5241 1586 1588 2492 PMC7707960__F2 Putative schematic of the Rac1 signaling pathways involved in different neurodevelopmental disorders 3064 85358 26053 627 2066 3084 8205 63916 5879 PMC7709261__F1 Outline of TGFB signaling pathway regulating HCC initiation and progression 1956 3845 6774 558 4318 1000 7048 4609 619501 7057 7046 5111 960 1499 942 10225 PMC7709275__F5 LncRNAs regulate the tumor characteristics apoptosis (a), invasion and metastasis (b), and metabolism (c) by regulating the UPR 100996301 5954 22926 83939 468 255082 647979 283131 112398 2539 PMC7711884__F1 Graphic scheme of the genes involved in the adsorption, distribution, metabolism and excretion (ADME) of fluoropyrimidines 10864 9429 1066 8824 978 1548 7378 151531 51733 1890 1806 1807 7372 5471 7083 83549 7371 6240 6241 7298 2030 10057 10257 8714 PMC7713372__F4 Functional profile of main vitamin D target genes 366 1591 1593 2203 6280 10501 50486 7057 219972 6369 7045 23166 5008 8437 7056 1839 3122 3123 3914 PMC7714584__F6 Target-pathway network 4312 4314 3553 4318 3284 5328 6373 5743 3627 6696 8644 9429 PMC7718039__F3 Mitochondria-mediated regulated cell death 142 759 637 7124 8772 197259 8737 11035 PMC7718880__F8 Schematic diagram illustrates the mechanism for the effect of the oxalate/LCN2/ERK and p-ERK and the expressions of LCN2, PTGS1, GPX3 and MMD axises on renal epithelial cell damage during kidney stone formation 3934 2878 5742 23531 PMC7719135__F2 Mechanism how MCPIP1 and cytokines mutually regulated in macrophages 7099 729230 4615 7189 2002 9100 10010 57510 PMC7719303__F2 Inflammation and ROS 6649 55312 8737 10628 10811 124056 7186 114548 56616 6387 3553 3603 8717 8772 140823 PMC7720011__F3 Possible relation of prostate cancer to viral pathogenesis 10935 10549 142 2078 1636 6692 59272 6935 9839 5292 PMC7723893__F1 TNFR1 activation pathway 7186 8737 1540 8717 10487 11035 197259 PMC7724447__F1 Role of statins and PCSK9 inhibitors in COVID-19 pathophysiology and complications 255738 59272 3949 4615 PMC7728170__F2 Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis 6364 4513 6279 6280 4312 4318 PMC7729028__F4 MEKK3–MEK5–ERK5–KLF2/4 signalling pathway 889 7099 3553 998 10365 9314 9507 PMC7729279__F2 Illustration of molecular signaling involved in SARS-CoV-2 infection 57506 59272 3454 3455 7113 6773 115004 51311 51284 4615 6772 29110 3661 3665 3553 PMC7729760__F1 Autophagy—A Hidden but Important Actor on Oral Cancer Scene 7249 7248 2475 8408 60673 9776 PMC7729937__F11 Proposed mechanism of the differential actions of arecoline on cell growth among RWPE-1 (A), PC-3 (B), and LNCaP (C) cells 891 896 983 595 1019 PMC7732991__F7 OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression 165140 100187761 10399 PMC7734179__F1 Cytosolic DNA sensing pathways 54106 79792 4615 6778 2475 7189 9447 PMC7736605__F1 Autophagy influence on tumor-associated antigen presentation 1 941 942 940 920 7054 PMC7743012__F4 Activation of cancer‐related signaling pathways 6608 29065 51684 2932 4087 2735 100652772 324 4089 5728 2475 652995 1499 595 7099 84981 23642 3169 347689 100750225 PMC7746343__F8 ATR-CHK1 and ATM-CHK2 in the cell cycle pathway 472 545 993 994 995 1017 983 PMC7746538__F2 Cathepsins in macrophage functions during bacterial infection 7098 1513 1514 1508 1509 4615 3661 8411 1520 107966124 3920 3916 114548 PMC7746877__F2 Therapeutic potential of BMSC-derived exosomes for PF and the potential molecular mechanisms 6010 999 1499 324 PMC7747940__F2 Porphyromonas gingivalis: Immune subversion activities and role in periodontal dysbiosis 7097 7096 7852 114609 4615 PMC7750564__F1 NFKB signaling pathway is involved in the transcription of HIV which can be exploited for HIV cure studies 5037 7186 7187 330 329 5894 5971 PMC7751007__F3 Notch signaling pathway 1950 11319 896 23462 3280 9794 PMC7751369__F10 Protein-protein and gene-gene interaction networks among CCNB2, CCNE2, CDK4, HOMER1, HSP90AA1, NRAS, PPP2CA, PRKAA2 and RAC1 9454 23678 1030 890 1021 1527 5563 3320 9134 23023 1017 1019 9133 9911 1029 5515 9456 1729 10110 5879 4893 57458 25843 2915 85417 2911 5495 10131 PMC7751413__F1 P53 signaling pathway of the large yellow croaker (Larimichthys crocea) responds to acute cold stress: evidence via spatiotemporal expression analysis of p53, p21, MDM2, IGF-1, Gadd45, Fas, and Akt 841 1021 1019 355 2475 5728 7249 4193 64326 6477 PMC7753952__F1 LKB1 in glucose metabolic reprogramming 2539 2147 2597 7249 23235 7248 2023 6009 3939 2475 64784 9759 83933 PMC7757029__F3 Alternations of signal pathway of MYC in breast cancer tumorigenesis 100188776 4040 4041 2353 3845 1499 6667 3725 4609 7157 2099 1019 324 5925 1021 595 51176 1869 PMC7758250__F1 Immune responses elicited by Plasmodium infection 5132 51284 54106 3665 920 57506 3661 115004 2821 9447 3553 114548 PMC7758250__F2 Immune regulators in anti-malaria immunity 7098 51284 54106 958 151888 4615 8651 3383 8061 57506 56244 7189 3902 7187 940 1493 29110 64108 3661 3665 201633 2002 PMC7760327__F1 Cellular copper homeostasis in hepatocytes (A) and fibroblasts (B) 10063 6647 9997 6341 1356 9973 540 1506 475 1431 4015 538 6649 PMC7760557__F9 Melatonin in mitochondria of WT mice during cardiac aging 4280 114548 9927 275 3162 9817 8772 9118 PMC7760557__F10 Melatonin in mitochondria of NLRP3−/− mice during cardiac aging 114548 4280 9927 275 3162 9817 8772 PMC7760867__F1 Relapse-associated genes and pathways interacting with R-CHOP immunochemotherapy 613 930 4609 4193 596 472 545 581 4170 PMC7761947__F2 TRPM1 role in visual pathways 4308 80036 2475 9776 10645 PMC7762932__F1 PC and PE biosynthesis via two branches of the Kennedy pathway 55224 8711 1120 1152 1119 100379198 907 5091 10390 PMC7763279__F2 Wingless and Int-1 (WNT) signaling pathways and their role during the osteochondrogenic transition of synthetic vascular smooth muscle cells (VSMC) 7474 89780 4919 4920 4035 4040 4041 1499 6660 55553 6662 860 176 1280 4322 PMC7763974__F4 Apoptosis induced by high levels of NO is mediated via activation of the extrinsic apoptosis pathway which involves the TNFR and Fas/Death Receptors 355 8717 7186 8772 7189 8195 637 581 PMC7764345__F1 Insulin signaling pathway; Insulin stimulates the insulin receptor (IR), leading to phosphorylation of insulin receptor substrate (IRS) 5163 3667 8660 PMC7764760__F3 Pathway diagram of EGFR post-endocytic fate 1956 5338 382 387 6010 7251 685 1950 7039 PMC7765045__F1 Main pharmacogenetic biomarkers associated with conventional synthetic disease-modifying antirheumatic drug (csDMARD) treatment 6573 5981 4524 1723 1719 7172 471 3704 10 9429 PMC7765557__F2 Leptin-induced signaling pathways 1956 6247 3717 387 6093 6714 2885 5728 2475 1499 6774 4852 181 9021 5443 2308 PMC7767644__F1 Autophagy is mediated by multiple signaling pathways that creating an interaction network system 7249 7248 6009 2475 8408 2309 PMC7767860__F2 Canonical and non-canonical pathways of TGFB signaling 4087 4089 4088 4086 4090 4091 4092 2475 6497 PMC7770133__F2 Summary of reverse MHC-I signaling pathways in various cell types 567 6714 7535 3932 4615 7297 7189 6774 5966 387 6497 4313 572 2475 3553 PMC7772402__F1 Schematic presentation of early steps of SARS-CoV-2 life cycle 59272 7113 6476 PMC7773022__F9 Proposed model of LPS/JNK/Sp1 or Nrf1 signaling pathways in regulation of TRIM59 expression 6667 4899 286827 PMC7774657__F1 Aspirin’s role in colorectal cancer prevention Cyclooxygenase (COX) dependent pathway (Left panel): Inhibition of COX-1 in platelets and COX-2 in epithelial cells 7124 2919 4512 1499 PMC7775424__F5 Hypothetical contribution of exRNA to virus infection and subsequent cardiovascular disease 6035 59272 8829 PMC7778590__F1 Core components of the Hippo pathway in mammalian cells 60485 4485 9113 26524 4771 9686 PMC7779757__F1 WNT pathaway signaling 55366 8549 84133 324 23002 1499 64840 51176 PMC7784512__F4 Schematic proposed mechanism of inflammatory downstream signaling pathway in lung epithelial cells undergoing hypoxia–reperfusion stimulation 7099 4615 3553 PMC7788945__F1 IL-22R downstream signal transduction pathways 3716 7297 6774 6772 PMC7791970__F7 Schema of the signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production 7099 4615 114548 3603 PMC7792222__F5 miRNA-mediated regulation of the BCSCs via targeting the BMI-1 signaling pathway 648 6015 5163 1019 4193 PMC7793297__F13 Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells 7124 958 6295 7099 861 864 8178 PMC7793792__F1 Regulatory mechanisms of ferroptosis 9474 10533 2932 8031 3658 2879 55240 7018 2643 23657 23410 51780 PMC7794007__F1 Diagrams depicting the Sestrins-mediated stress signaling pathways and functional domains of Sestrin2 in the regulation of metabolism and disease 9817 8408 3667 54546 9978 1283 PMC7795265__F6a Proteomic Profiling of the First Human Dental Pulp Mesenchymal Stem/Stromal Cells from Carbonic Anhydrase II Deficiency Osteopetrosis Patients 2773 10979 2720 3033 4904 4151 55818 5118 9049 6275 5352 PMC7796211__F2 BMI1, ARF, MDM2, MDM4, E4F1, and p53 proteins shuttle between different subcellular compartments where they control different metabolic functions 4194 4193 1877 468 648 PMC7797784__F6 Proposed mechanism of action of JC-5411 via activation of Nrf2 pathway against arteriosclerosis 9817 2729 2730 3949 1374 355 114548 3553 PMC7798030__F2 p21 is regulated by multiple pathways 688 9314 84417 55553 5111 8237 PMC7799025__F1 IL-6 receptor and signaling 7187 2549 9846 6774 PMC7799400__F1 COVID-19 pathogenesis and MSCs role in the elimination of SARS-CoV-2 related complications (1) SARS-CoV-2 enters alveolar type II cells through binding ACE2 3082 59272 3479 1080 9242 PMC7803292__F15 Involvement of the Akt and Kras pathway in breast cancer 5782 7163 114569 3845 2475 4193 999 1019 11279 51274 1869 PMC7803748__F1 Muscle atrophy and hypertrophy: implications in health and disease 3479 5163 3667 6009 7249 7248 2475 253260 664 23710 23198 5717 8408 79791 10277 9097 PMC7808154__F2 Interleukin‐17 and ischaemic stroke 339855 2335 7189 23118 257397 10682 2932 7186 7188 7187 9618 PMC7808935__F2 Counteracting CAR T cell dysfunction 10219 472 545 5163 PMC7812690__F4 Cardiotoxic effects of angiogenesis inhibitors 5159 572 581 2475 PMC7813674__F1 NFKB signaling pathway 7097 51311 54106 7099 10333 7100 51284 7098 8717 4615 7186 7188 51135 7189 23118 257397 10454 3654 PMC7814631__F6 Cell signaling pathways in the epigenetic regulation of myogenesis 2146 7528 5081 1499 4617 3479 87 1158 4656 10498 PMC7817929__F3 Molecular Features of the Serrated Pathway to Colorectal Cancer: Current Knowledge and Future Directions 673 3845 3240 54894 84133 4163 8313 4292 4255 7157 PMC7818013__F3 DNA double-strand break repair pathway choice: a new focus on 53BP1 9656 9025 165918 55183 672 5888 PMC7818015__F4 DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy 7737 5889 221120 PMC7822898__F6 Construction of lncRNA-related PPI networks linked to drug responsiveness in DLBCL 9869 2475 1977 596 100124700 6657 4792 7503 208 6774 10533 9274 PMC7824611__F5 Proposed model of Cholix-induced cell death pathways 4035 5045 1938 6093 PMC7826706__F1 Hedgehog (Hh) signaling pathway contributes to hepatic carcinogenesis 6608 4087 4088 5727 51684 79923 960 4089 6935 4363 6890 PMC7826847__F3 C-CAMs involvement in radial migration during neocortical development 5818 1000 25945 7436 1600 6714 1499 1398 1399 1356 1002 2638 PMC7830297__F1 TLR4 signaling pathway 7099 51135 7189 10454 257397 23118 7187 29110 3661 4615 114609 PMC7830527__F3 Proposed CD38-dependent mechanisms of hyperprogression 135 85451 3091 952 3480 3479 3481 285 PMC7830727__F3 Canonical, non-canonical, and caspase-3-dependent pyroptotic cell death pathway 22861 114548 58484 9447 79792 1687 3553 PMC7833179__F1 Could Oral Phosphodiesterase 5 Inhibitors Have a Potential Adjuvant Role in Combating COVID-19 Infection? 596 23411 23410 7124 90865 4284 3603 7494 875 PMC7834777__F8 Predicted mechanism after administering TCN in the liver 5465 7351 4280 PMC7840052__F7 Chinese wolfberry and Astragalus extract on the antioxidant capacity of Tibetan pig liver 5805 5190 5189 9409 55670 5828 5192 5193 5195 5194 5824 4358 5827 11264 PMC7840718__F3 Wnt growth factor triggers macropinocytosis by binding to co-receptors Frizzled (Fz) and LDL receptor-related protein 6 (Lrp6) on the cell surface 4040 5058 3276 1499 324 2932 PMC7840724__F8 Schematic model for radiation induced opposite invasion and migration potential in HCT116 and DLD-1 cells 207 208 302 2932 999 PMC7842751__F9 Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway 10235 9693 2002 1958 6722 PMC7845757__F7 Mechanisms underlying DAC-paracetamol interaction 1571 4513 4015 PMC7847180__F8 Network analysis 1950 3486 4151 2214 7046 5819 100506658 94134 387 394 390 4301 PMC7847503__F7 Summarized molecular mechanisms of the signaling pathway involving the EGFR, TrkB, KRAS HIF-1A and VEGF-A genes; adapted from 1950 627 7422 1956 2885 3845 468 PMC7847688__F3 Roles of Pin1 in virus infection 5300 595 6774 1499 PMC7848457__F9 Proposed model of molecular targets of NSAIDs in enhancing Hsp90 inhibitor cytotoxicity of CD44highK562 cells 6774 2475 3297 960 PMC7855707__F2 In the absence of IFN (left), constitutively internalized IFNAR1 and IFNAR2 subunits may recycle from the sorting endosome to the PM 3455 6642 6643 27131 58533 3454 51699 55737 8724 PMC7855863__F3 Key Metabolic Functions of Beta-Arrestins: Studies with Novel Mouse Models 6256 3667 181 PMC7857091__F1 Deciphering the Intricate Roles of Radiation Therapy and Complement Activation in Cancer 717 727 10747 1378 1604 1369 730 729 735 966 7448 PMC7859115__F3 Cellular and molecular features of autophagy 2475 9776 60673 8408 9474 9140 55054 PMC7859290__F1 Biosynthesis of the molybdenum cofactor (Moco) and metabolic pathway of sulfur amino acids and purine degradation 27304 4338 10243 PMC7859322__F2 EMT-related lncRNA in the process of triple-negative breast cancer metastasis 100302126 4316 9839 5727 2735 57291 101805488 PMC7859355__F8 Schematic depiction of our proposed model of the role of ROS in the regulation of FGF2-induced AKT phosphorylation in hPSCs 2247 5728 2260 PMC7862576__F7 Mdfi overexpression promoted C2C12 cell differentiation and positively modulated fast-to-slow-twitch muscle fibers transformation 4188 816 5166 1431 7135 54331 34 4151 51 54205 2621 2153 226 PMC7862630__F3 Deubiquitylases in developmental ubiquitin signaling and congenital diseases 55593 7874 83844 114803 27005 23326 10600 84101 8314 7398 7375 9958 4089 55611 8239 PMC7864727__F1 Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor 2242 27035 1803 8031 55240 3315 2182 PMC7865493__F1 Aryl hydrocarbon receptor (AhR) signaling pathways: canonical (A) and noncanonical (B) 196 1956 405 8614 1316 3553 50616 3569 PMC7865703__F2 STAT3 pathway activation represents a focal point of tumorigenesis and immune escape 1956 10401 50943 596 920 79923 941 942 6347 PMC7865812__F1 Contribution of transcription factors (TFs) to disease progression 3091 4609 367 3169 7494 2146 7157 6658 6657 30812 55553 6662 6660 6659 83595 7291 5925 429 PMC7867281__F1 Principal functional interactions between lncRNA HOTAIR and different microRNAs 1021 1019 2262 1602 558 6774 3718 6347 2475 2246 100124700 27 57575 6362 3135 4854 PMC7868402__F4 Illustration of SIRT1 signaling pathway in bone remodeling (; ; ; ; ; ; ) 6657 23411 860 PMC7869011__F4 Retinoic acid (RA) synthesis and signaling activation during in vitro cardiac differentiation 5947 5950 157506 9227 5914 5915 6258 PMC7869012__F6 Bioinformatics analysis of sevoflurane altered lncRNA-related pathways based on the dysregulated lncRNA co-expressed dysregulated mRNAs using ingenuity pathway analysis (IPA) software 3952 11280 25948 229 2670 187 1961 2100 140809 1847 116 4982 3725 6430 7903 8013 196500 5295 30061 8698 PMC7870860__F1 Central role of self-nucleic acids in obesity-mediated metaflammation 3146 51284 115004 7098 9447 114548 54106 3569 4615 3661 3665 PMC7874475__F9 Protein-protein interaction network 9839 1009 10797 220965 9508 4094 5396 2200 1462 800 6383 7837 2202 51460 10592 23397 7045 25788 10051 64151 8318 9918 87178 PMC7877185__F1 Competing endogenous RNAs (CeRNAs) and the signaling pathways involved in lung cancer cell proliferation 1950 3481 6502 3667 5728 6241 339290 4609 221883 283120 1870 1871 1540 5111 1017 1021 8900 890 554203 PMC7879635__F9 Signaling pathways affected by exosomal miR-199a-3p/145-5p 928 939 967 867 868 4803 PMC7880438__F8 PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation 4077 57506 6048 29110 3661 PMC7881277__F2 Deregulated MicroRNAs in Age-Related Macular Degeneration Pathology 2149 7035 2152 1361 2155 2159 2147 2153 2160 2158 2157 7450 7056 2 5624 5327 5328 5329 2161 5340 3818 966 718 729 730 735 717 720 1380 PMC7881399__F2 Cluster-2 including 19 nodes and 111 edges 6863 4295 1636 3630 796 885 5539 2641 594857 2520 85480 6279 PMC7881399__F5 Results of biochemical pathway analysis of hub-bottlenecks plus seeds of cluster-1 and 2 via ClueGO+CluePedia analysis 4586 5743 3630 213 3576 7422 1956 9370 PMC7882108__F8 VD3 ameliorated NM‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway 4827 23410 6648 114548 3603 PMC7882971__F6 LETM1 down‐regulation‐induced autophagy in CRC cells 3954 2475 6648 8011 PMC7883293__F8 ESM1 drives PCa metastasis by coordinating with the Wnt/B‐catenin pathway 4040 4041 1499 11082 2932 324 6925 PMC7884239__F1 Role of ACE (angiotensin-converting enzyme)-2 in the pathogenesis of coronavirus disease 2019 (COVID-19) 59272 1636 367 6868 PMC7885861__F1 Expression and function of the insulin/insulin-like growth factor system in glioblastoma cells 3643 3667 5728 2475 3485 3611 1956 6774 PMC7886236__F3 Insulin-like factor-1 (IGF-1) signaling and the multiple pathway axis 3479 3480 1956 3667 PMC7886759__F3 Lipotoxic UPR induces hepatic cell death 7186 83939 467 596 PMC7886759__F4 Modes of cell death in NASH 197259 79792 114548 355 PMC7890213__F1 Physiology of Nrf2 activation in both normal and stress conditions 8452 4094 9817 PMC7894323__F6 Infigratinib and ribociclib in inducing differentiation and preventing dedifferentiation 10818 2885 1017 2475 595 1021 1019 6662 983 PMC7894993__F2 Extrinsic and intrinsic factors that regulate self-renewal in embryonic and adult haematopoiesis 3684 5159 4352 161742 389421 64321 2146 468 1788 54790 2145 2672 PMC7895520__F7 Mechanism of the protective effect of spermine against high glucose-induced diabetic podocyte injury 2475 8878 9474 PMC7896749__F3 LncRNA‐mediated posttranslational modification of other proteins involved in metabolic pathways 1660 378938 2521 23411 4193 PMC7898953__F5 Effect of miRNAs on the Hippo pathway and the actin cytoskeleton 60485 1499 4485 57551 9113 26524 23012 100302183 5217 57553 5756 7114 1073 8048 154810 1000 79633 PMC7900430__F2 Mechanism of the inhibitory role of Wnt/Beta-catenin pathway in preadipocytes during adipogenesis 4040 4041 324 2932 1499 PMC7905525__F2 Signaling pathways associated with AQP5 in cancer 362 1956 4088 4087 1499 PMC7905558__F7 Experimental framework 4485 9113 26524 999 1499 4313 PMC7906148__F4 Analysis of 219 hub genes with degree ≥10 3371 4602 3667 2318 55811 1942 5743 54567 650 10411 8651 64218 1080 7476 1948 1513 4688 7869 653361 2354 57216 PMC7906182__F4 Interacting networks between coiled-coil domain-containing protein 167 (CCDC167) and micro (mi)RNA 100422837 3480 4313 4318 2572 4088 27161 3417 468 650 4087 5310 6422 860 6667 9241 100616250 3199 PMC7911352__F4 Other metabolic pathways that regulate ferroptosis 27165 2805 7417 7419 8878 4734 2305 2879 92745 6510 PMC7913036__F1 Iron cycle in the tumor microenvironment (TME) 7018 6774 3934 920 9332 1356 3553 PMC7915065__F1 Signaling pathways and factors involved in programmed cell death ligand-1(PD-L1)-induced resistance 1956 6774 10413 1786 PMC7915224__F5 RAS regulation by posttranslational modifications 3845 3265 64750 100420631 1499 9610 2932 8216 6714 PMC7916193__F6 Pathways involved in cutaneous squamous cell carcinoma (cSCC) pathogenesis 1956 1021 1019 595 3664 3280 5728 2885 5921 2475 PMC7916550__F5 Ingenuity Pathway Analysis downstream function prediction of the overlapping differentially expressed genes from the liver 3 h heat-control contrast and 4-week to 3 h control time contrast 4017 89932 1300 340554 4161 6445 58513 7048 27231 9380 7286 26519 200576 22873 9563 22849 125988 83758 81892 64105 1030 6241 51388 9837 PMC7916951__F1 Multiple intracellular pathways triggered by Cytomegalovirus (CMV) and Epstein–Barr virus (EBV) infection converge on expression of proinflammatory cytokines and type I Interferon (IFN) response genes 7097 115004 4615 51284 7189 7187 3660 3665 3661 PMC7917704__F5 HMGA2 induces EMT by activation of different signaling transducers 7049 2885 3037 8091 2475 4853 4854 6774 999 PMC7917723__F1 Absorption, and excretion pathway of gut-derived uremic toxins 1571 6817 10249 471 PMC7918312__F7 Schematic illustration showing activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway and how PRKAR1B-AS2 regulates it 101927000 5728 5163 7249 7248 6194 PMC7922523__F4 TGFB/EMT signalling in pSS 7046 7049 4087 4088 4089 999 PMC7922891__F7 Hereditary disorder, metabolic disease, organismal injury and abnormalities network affected in lymphoblastoid cells derived from an SS patient 112487 259295 10242 91010 56986 51181 474344 80018 79958 93349 9130 79706 170959 255394 2491 54014 63935 79712 PMC7922891__F10 Graphical summary of expression profiling of human lymphoblastoid cells derived from an SS patient 3601 6403 51411 51274 2099 PMC7923337__F8 Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer 2626 10885 10413 PMC7923925__F1 The Hippo Pathway in Breast Cancer Carcinogenesis, Prognosis, and Treatment: A Systematic Review 999 84962 4771 4139 8463 7003 7005 7004 595 558 2736 4609 PMC7924631__F1 Overnutrition leads to increased gluconeogenic gene expression by altering gut microbiota and lipopolysaccharide (LPS) production 929 7099 7494 200186 2308 PMC7926484__F3 Dysregulated pathways governing liver hepcidin expression in PAH 654 655 7036 4087 4088 4089 4090 4086 6774 57817 3077 PMC7926708__F8 Brief overview of the autophagy pathway, which is a catabolic process that includes a specific intracellular cargo, such as organelles or endosomal contents that are intended for degradation 55054 10533 64422 8678 30849 5289 5209 8408 PMC7927199__F9 Proposed schematic model summarizing the role of GNL1 as an antiapoptotic protein 581 637 2794 596 10961 PMC7929492__F1 Canonical activation pathway for the NLRP3 inflammasome 114548 7099 4615 5970 3553 PMC7935919__F3 Schematic illustration showing altered coagulation pathway proteins in polycystic ovary syndrome (PCOS) 7018 7035 7450 5340 2224 PMC7936245__F4 Possible proximal tubule epithelial cell signals in glomerulonephritis and renal cell carcinoma 6347 23411 114548 6774 8074 1594 1591 5741 2056 54908 PMC7937931__F4 ERBB2/VEGFA-AKT-PI3K-VEGFR signaling pathway and autocrine VEGFA signaling loop 3486 3480 1956 7422 5728 207 7249 7248 6009 2475 PMC7938710__F3 Network analysis using the Ingenuity®Pathway Analysis (IPA®) software program 229 221395 30817 842 1813 1841 64167 7251 6754 6554 221472 81492 8484 2835 56834 4935 9290 135112 85451 PMC7946814__F1 Sclerostin: an inhibitor of canonical Wnt signaling pathway 324 1499 4040 4041 PMC7946926__F8 Transport mechanism 7077 5594 7006 100124696 3178 PMC7947273__F4 Life Without Thyroid Hormone Receptor 8549 4440 3276 PMC7947867__F4 Model showing plasma membrane NKCC1 and mitochondrial respiration: a link through leucine? Aerobic respiration utilizes the KREBS cycle and the electron transport chain 3667 5611 7494 6648 PMC7951058__F4 Molecular pathway and network analysis of proteomics analysis of differentially expressed proteins in LTLT-Ca mammospheres and LTLT-Ca adherent cells 10776 4931 9805 6729 23256 2935 23589 27043 1476 2193 55313 92344 10469 84749 57153 9804 54543 PMC7952134__F7 PPP2R5D E420K-variant signaling 3479 3480 208 1499 5528 7249 2931 2932 6194 PMC7952444__F4 Aberrant expression of PIWIL1 mediates tumorigenesis and progression 9271 1786 5728 2475 999 648 79923 1000 PMC7955431__F1 Coronavirus Disease 2019–Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management 7113 2040 59272 3606 5340 PMC7956519__F3 Major non-canonical mechanisms derived from CALRMut 3309 3313 3312 10398 6135 124540 324 2313 2923 55074 6892 6891 PMC7956893__F4 PPs inhibit cancer cell proliferation and induce apoptosis in cancer cells through the NF-kB and MAPK pathways 7808 841 581 2146 1786 PMC7958998__F2 From genetics to pharmacological treatment.Notes: Bone morphogenetic protein receptor II, BMPR-II; BMP-responsive element, BRE; Caveolin-1, CAV1; 12-kDa FK506-binding protein, FKBP12 857 659 3777 4090 4086 4089 PMC7960940__F8 IPA networks analysis of differentially expressed proteins in G6PC3 deficiencyIngenuity Pathway Analysis (IPA)-based network 2 of the 148 differentially expressed protein panel 6285 3727 177 100187761 3569 2147 2157 129685 6348 940 3596 7450 3501 2158 6288 3502 958 183 2811 2153 944 4170 3665 6304 3301 3043 PMC7963035__F1 NAD+ metabolism and its roles in cellular processes during ageing 160728 9390 952 84561 8140 120103 93100 64802 349565 23057 10135 8942 65220 23475 92014 22933 23098 23411 51548 51547 23410 23409 23408 PMC7963165__F1 Upstream mediators of TXNIP signaling 7099 4615 7295 22809 10628 114548 5728 79792 PMC7967251__F2 Crosstalk between the p53 and sphingolipid pathways.The complex interplay of p53 with key enzymes of the sphingolipid metabolic pathway in modulating DDR is shown above 253782 472 545 91012 340485 427 8877 PMC7968835__F3 Towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe 10125 5745 4067 93589 148 PMC7969441__F3 Telomere signaling pathway linking DNA damage response (DDR) and activation of ATM/ATR kinase, cycle arrest, and initiation of DNA damage 545 25913 472 PMC7970828__F6 Synthesis Pathway and Protein-Protein Interaction (PPI) Network of the Elevated IGPs Modified by HM Glycans in Tumor 5589 4121 100187761 3916 5660 5954 3371 1509 427 3122 5641 8836 60681 1075 2799 5351 871 PMC7973041__F3 m6A modification participates in innate immunity via regulating the recognitions of unmodified transcribed RNA (tRNA), invading pathogens, exogenous RNAs, and aberrant endogenous double-stranded RNA (dsRNA) 51284 7098 57506 4553 83939 6041 PMC7979776__F7 Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCA and TSC2-mTOR downregulation 5091 26353 9531 11155 10273 3312 7249 PMC7979820__F4 Epigenetic mechanisms in breast cancer therapy and resistance 2146 8085 1786 3169 8289 58508 10765 PMC7980524__F1 Structural and functional understanding of the toll‐like receptors 7097 7098 7099 7100 10333 51284 7096 51311 54106 81793 4118 122769 4615 7189 3665 7187 29110 3661 PMC7981899__F1 Chemokines and their receptors’ roles in acute lymphoblastic leukemia 6363 6387 6370 2833 1236 10803 6714 25 4609 4318 4851 6774 387 389 5879 7535 PMC7982393__F1 Physiological and pathological functions of the RAS 1636 59272 545 PMC7987693__F1 TGFB signaling pathways in EMT 7939 7189 2885 4092 998 5879 387 4087 4089 5062 2475 1499 4318 4313 1000 999 9839 6935 283120 378938 PMC7988727__F6 Prenatal indole-3-carbinol administration activates aryl hydrocarbon receptor-responsive genes and attenuates lung injury in a bronchopulmonary dysplasia model  8717 7186 4317 PMC7989705__F3 Solute carrier (SLC) expression is associated with cell death 6520 23657 55630 1317 11254 54623 145482 2879 PMC7993397__F1 Integration of mechanical- and ECM-based tumor microenvironment-imposed signals 63895 2534 2886 10395 5163 4771 387 3611 154796 4485 9113 26524 960 PMC7993678__F6 Cancer associated fibroblasts (CAFs) from osimertinib-resistant patients promoted osimertinib resistance via HGF/MET signaling and induction of epithelial-to-mesenchymal transition (EMT) and transformed NSCLC cells into TKI resistant stem-like cells 3082 1956 1499 PMC7996181__F8 Hippo pathway and the role of YAP and TAZ in mechanotransduction of SC activity 4018 4771 4485 6010 9113 26524 154796 10207 5728 7003 8463 7004 7005 PMC7996755__F1 Schematic presentation of Nrf2 signaling pathway 9978 8452 9817 2730 2729 PMC7998362__F7 Four identified pathways responsible for P 7389 7390 210 1371 5498 2235 7498 7306 7054 5053 6697 5805 367 PMC7998878__F3 TRIM8, NFKB and JAK-STAT pathways 3458 79931 81603 6774 10401 PMC7998891__F6 Molecular components of BCG-driven inflammation in bladder cancer microenvironment 4513 4283 3576 3620 3627 6367 3577 2833 1233 PMC7999074__F1 Hippo signaling pathway comprises a cascade of phosphorylation and activation of kinases, which ultimately regulate YAP and TAZ subcellular localization 4485 60485 9113 4771 9686 PMC7999260__F4 General principle of the HSV-TK suicide gene system 7124 8772 472 PMC8000424__F5 Effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling 5163 6446 5728 5087 3169 2309 4170 572 596 5544 2099 4609 894 653247 1017 PMC8000459__F3 GP6 Signaling Pathway in HS line of Japanese quail 27040 51206 695 4067 5747 391 10235 29970 5879 PMC8000576__F2 Mechanisms by which MYC induces apoptosis 23476 4149 4609 581 4193 317 PMC8001359__F9 ISL effect on TGFB1 induced epithelial-mesenchymal transition (EMT) in human endometrial cancer 1000 999 7040 4087 4088 4089 6935 PMC8001776__F2 Routes for the in vivo production of glyceraldehyde (GA)/methylglyoxal (MGO) 367 2597 2739 PMC8002185__F1 Serine/glycine biosynthesis pathway activation in cancer 26227 29968 5723 6470 6472 PMC8002185__F4 Linking radiotherapy resistance and serine/glycine metabolism in the tumor and associated tumor microenvironment 26227 3553 29968 5723 6472 PMC8002821__F3 Classical NFKB (Right) and STAT3 (left) activation pathways 6774 3082 7187 7186 2475 85451 5970 PMC8003624__F3 Fungal induction of necroptosis 6850 7186 64170 8737 11035 8915 10892 8772 8717 197259 PMC8004153__F3 Hypothetical scheme illustrating TGFB/EMT signalling in SS 3458 7046 7049 4089 4087 4088 4092 999 PMC8005457__F7 Pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF-7 breast cancer cells 596 581 142 PMC8005482__F1 Inactivation of tumor suppressors in GBM cells that affect GAM biology 6714 5728 10413 4015 4763 1234 1524 1499 6352 6347 6376 7124 7157 729230 2475 6774 PMC8005608__F3 TRIM-mediated regulation of innate immune signaling pathways 7099 10475 89122 10206 9830 7706 201292 81603 135644 81844 22954 7098 64127 51428 115004 56919 4615 51311 54106 51284 114548 57506 11074 7189 373 51295 7187 23118 257397 3603 10010 6737 23650 29110 117854 7726 3661 PMC8005985__F5 Regulatory function of main lncRNAs related to cardiomyocyte maturation 441951 51024 1602 11331 10413 1788 1397 4172 PMC8006187__F1 Network-based virus-host interaction prediction with application to SARS-CoV-2 59272 3661 51083 PMC8010701__F2 Mevalonate pathway 38 39 3157 3156 4598 10654 3652 1431 4597 2224 2222 6713 1718 1717 PMC8013702__F3 MuV infection of testicular somatic cells and downstream effects 8651 9021 9636 4599 7097 2621 3627 3569 PMC8013977__F6 IL-15–PI3K–AKT-mTOR signaling for NK cell development 5728 5163 7248 2625 84969 2113 8320 2308 PMC8015775__F11 Proposed model for a role of BANK1 in tolerant patients 613 355 6850 8772 7189 640 637 56616 55024 PMC8016325__F6 Moringa isothiocyanate-1 regulates Nrf2 and NFKB pathway in response to LPS-driven sepsis and inflammation 9817 3569 4094 PMC8016646__F1 FGF‐FGFR signalling pathway 2549 2885 10818 2475 53834 PMC8017335__F2 IL-1 family cytokines regulate NK-cell responses 90865 6775 1386 PMC8020248__F2 Dysregulated MET activation, signaling pathway, and tumorigenic consequence 3082 1956 3480 2885 1499 5266 PMC8023278__F11 Osteoclast differentiation signaling pathway ranked twenty-first in Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms 2885 6714 1540 7039 23118 10454 2274 7010 695 126014 10129 1513 6850 10326 54209 100187907 4286 8835 8651 10379 PMC8024302__F5 Effect of extracellular vesicles on the regulation of mitochondria under hypoxia 8011 3091 5163 56947 8408 9927 PMC8026578__F2 MicroRNAs in the pathophysiology of addiction 369 107 2891 2778 71 2770 1385 801 5908 5579 5604 100423038 60 5500 5566 100616174 5595 5501 815 100422990 100422914 100422929 2911 5594 5894 805 100302233 100616121 100302228 5567 5906 PMC8027612__F8 Protective effect of SAA on vascular permeability via inhibition of VEGFA-Src-MMP signaling pathway activation during acute ischemic stroke 1499 1003 7422 PMC8027889__F1 AHR and its signaling pathway 196 9049 6714 57491 405 1545 1544 3620 PMC8037620__F1 Spectrum of changes in a senescent cell 6347 6352 6355 1440 2920 355 3146 3383 3458 3485 3487 3659 5069 4318 4321 4322 4790 7412 5054 5055 7124 2475 1437 7422 3624 6354 1435 3486 3552 4314 2626 142 1017 PMC8038136__F1 CK1A and CK2 regulate many cellular processes that sustain the tumor phenotype 1499 2475 5728 2932 324 84433 10892 8915 468 11140 4193 PMC8038462__F2 DNA repair pathway in the prostate epithelium involving hereditary prostate cancer (HPCa) related genes: mismatch repair or MMR (A); homologous recombination or HR (B) 10111 672 11200 79728 675 4436 2956 4292 5395 9156 3978 PMC8039950__F3 Function and underlying mechanisms of sialylated IgG (s-IgG) in myeloid and B cells 1878 8178 613 933 51311 54106 51284 1435 90865 958 941 942 PMC8040296__F8 Protein-protein interaction in the PI3K-AKT signalling pathway and ECM-receptor interactions 9180 6446 56034 2149 59345 3559 1902 3371 5294 8074 1277 5228 10000 5156 2019 7422 7057 5159 2321 3569 7450 2250 3674 22801 1278 10319 3915 1284 3678 7058 7060 7059 PMC8040299__F10 Pattern diagram HHT influence miR-18a-3p and AKT/mTOR signaling pathway 581 596 5163 4318 2475 PMC8041338__F1 Imipridones in targeting mitochondrial metabolism in cancer cells 8192 10845 468 596 581 PMC8044831__F1 Anti-inflammatory mediated effects of phytochemicals along the TLR4 signaling pathway 7099 3654 51135 7189 4513 PMC8047216__F1 Stem cell migration 6373 2833 1232 7852 1233 627 2056 PMC8047423__F1 Complex regulation of HSC – and possibly hibernators – cell cycle entry 5728 3280 3726 2309 2475 8408 1019 1021 1017 PMC8056044__F6 Illustration of neuronal and astrocytic pathways implicated in the disease according to the top scoring genes according to our integrated ranking 351 55740 57522 118424 5216 7841 5062 5589 627 8841 8721 PMC8058565__F5 Sulfation of 25HC as an epigenetic regulatory pathway 1385 572 23411 857 847 858 859 3156 PMC8059835__F8 Hippo signaling pathway in podocytes after GSK3B knockdown 4771 79633 60485 4485 166824 84962 9113 4087 PMC8060460__F1 Process of neddylation modification of proteins 9039 8883 140739 4193 5728 1956 57154 7045 PMC8063606__F2 Pack a STRIPAK with hubs inside a hub 60485 4485 9113 26524 10413 PMC8064146__F5 Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment 10162 23761 1040 5091 259230 6319 339221 PMC8064518__F1 Canonical PI3K-mTOR and GATOR1 signaling pathway and mTORC1-independent pathways 2475 5728 6009 7249 7248 9681 8131 5163 10641 2290 2316 PMC8065873__F2 Anti-metastatic mechanisms of herbal medicine in colorectal cancer: Herbal medicines suppress angiogenesis, migration and invasion via inactivation of diverse HIF-1A pathways 7422 3479 7424 2064 4015 1956 6347 7852 6387 729230 6714 406984 406985 999 2932 1499 983 PMC8065873__F3 Anti-metastatic mechanisms of herbal medicine in gastric cancer: When it comes to ROS, it has double-edged aspects in anti-tumor efficacy and mechanisms 6935 1000 999 4353 998 2879 595 PMC8065873__F4 Anti-metastatic mechanisms of herbal medicine in liver cancer: Herbal medicines interrupt signaling transduction and EMT cascades related with cancer cell migration and metastasis 1746 6935 8490 999 1499 6774 7490 2475 7852 PMC8069355__F3 Speculative model of theta-mediated end joining (TMEJ)/Polθ activity as back-up repair of DSB in homologous recombination (HR) deficient cells 5888 5426 672 PMC8069505__F3 Important molecular mechanisms by which AEG-1 induces chemoresistance 5243 2475 1806 9474 218 PMC8070205__F2 Homologous-directed repair 672 7486 641 9156 1763 675 79728 5888 80198 348654 84464 116028 80010 2638 PMC8070205__F5 Activation of canonical STING Pathway upon replication stress or DNA damage 115004 472 672 5888 11277 25939 80198 3661 29110 PMC8070205__F8 Progerin expression in HGPS leads to DNA repair defect, replicative stress, and inflammation through DNA sensing in the cytosol 115004 6772 5888 5111 4361 672 55183 10111 PMC8073060__F2 Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction 771 11216 9590 9472 5144 3091 8165 4087 4088 PMC8073623__F1 New Insights into YES-Associated Protein Signaling Pathways in Hematological Malignancies: Diagnostic and Therapeutic Challenges 60485 4485 9113 26524 PMC8074086__F1 Mycosis Fungoides and Sézary Syndrome: An Integrative Review of the Pathophysiology, Molecular Drivers, and Targeted Therapy 5335 1233 1236 6363 6366 84433 50943 387 2625 6772 3716 6774 6775 6778 6777 3718 PMC8074097__F6 Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy 3603 22934 581 572 637 PMC8075059__F3 Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis 10913 1896 7042 999 PMC8075259__F2 Anaplasmataceae: Dichotomous Autophagic Interplay for Infection 5728 2107 7942 2932 7249 7248 6009 8878 22863 9474 3916 PMC8077906__F1 Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review 920 3932 2475 7535 940 PMC8079327__F4 Dyslipidemia in breast cancer patients increases the risk of SAR-CoV-2 infection 4015 4049 4050 PMC8080681__F2 Aberrant HNF4Alpha-related cell signaling pathways in cancer 999 1499 6774 6925 3554 3172 4087 4088 2932 PMC8080978__F5 Pathways enrichment of Walktrap modules 6773 6010 2475 2056 2322 7186 7187 2885 9020 330 329 5781 PMC8081528__F9 The mechanism of Txnip-mediated cone rescue 10628 142 3945 PMC8082422__F2 Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets 5163 9965 2549 2885 10818 152831 2932 1499 2264 PMC8082504__F10 Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway 5290 627 4915 3606 4780 2878 3162 PMC8086092__F12 Comparative transcriptomic analysis reveals the regulatory mechanism of the gibberellic acid pathway of Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn.) dwarf mutants 2520 51083 6500 8139 PMC8087647__F2 Impact of tumour autonomous autophagy on immunity 6374 6387 9447 3661 6352 7010 4077 4283 3627 PMC8091781__F10 COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/Beta-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells 1499 324 2932 595 332 4739 PMC8091816__F4 Sulforaphane suppresses lipopolysaccharide‐ and Pam3CysSerLys4‐mediated inflammation in chronic obstructive pulmonary disease via toll‐like receptors 7099 114609 4615 51135 7097 PMC8092973__F1 Simplified schematics of the mechanisms of replication fork restart upon replication stress 201973 353497 11201 51426 51455 4172 4174 4173 4176 4175 4171 8318 50485 84083 6596 84893 5888 55086 672 580 675 79728 5889 7516 2175 2177 5893 55218 5111 25939 1108 4361 9156 142 546 9739 56897 80198 84464 84515 254394 78995 10714 PMC8093976__F4 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases 23129 9723 6010 5879 54567 PMC8093976__F3 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases 64218 23129 7422 10512 1003 8829 382 23616 5879 223117 PMC8100490__F7 Zearalenone exposure affects the Wnt/Beta-catenin signaling pathway and related genes of porcine endometrial epithelial cells in vitro 4040 4041 2932 324 1499 4089 4088 7517 6118 7398 595 PMC8100510__F1 Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies 2735 51684 6608 2736 2737 324 1499 PMC8100607__F1 Reporters of Cancer Stem Cells as a Tool for Drug Discovery 6657 79923 9429 8205 PMC8100607__F3 Reporters of Cancer Stem Cells as a Tool for Drug Discovery 6657 216 79923 1499 2302 PMC8102505__F1 Autophagy pathway 9140 83734 10533 55626 7189 26100 64422 8678 22863 8408 7405 8878 9776 9342 55014 PMC8102695__F1 Use of the Anticoagulant Heparin and Corticosteroid Dexamethasone as Prominent Treatments for COVID-19 54623 324 7035 59272 PMC8104092__F5 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication 5909 857 6714 6774 2885 PMC8105434__F8 Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism 3553 22926 114548 PMC8107278__F1 Using Biosensors to Study Protein–Protein Interaction in the Hippo Pathway 9113 4485 60485 81532 PMC8108028__F1 BRCA mutated pancreatic cancer: A change is coming 472 672 5888 675 79728 PMC8108031__F1 Repurposing metformin for the treatment of gastrointestinal cancer 100187761 2475 3479 3480 PMC8111493__F1 Regulatory T cells in ischemic stroke 4318 6774 1234 6352 1237 1956 374 6346 6364 1235 PMC8113651__F2 Effect of autophagy modulation on HIV-1 infection 920 10013 9474 9140 89849 10533 8678 8408 7805 1201 30849 8394 382 PMC8113812__F3 Role of exosomes derived from serum in sepsis 3553 7124 4353 355 4615 3565 494327 3146 8651 5163 2475 572 PMC8113812__F5 Role of exosomes derived from epithelial and endothelial cells in sepsis 7124 920 3654 6093 7189 5728 3553 PMC8113860__F3 Crosstalk and regulation of innate immune cells in the esophageal cancer tumor microenvironment 140885 3146 999 961 6364 6347 6774 4283 3627 3486 58191 2920 2921 PMC8114929__F3 Rhizopine signalling to control PGPR 6476 283871 65057 PMC8115323__F1 WNK-SPAK-NCC pathway and WNK ubiquitination by the CUL3-KLHL3 E3 ubiquitin ligase complex 130497 65125 65266 907 26249 8452 PMC8116604__F4 Evolving landscape of N6-methyladenosine modification in the tumor microenvironment 619501 2638 5091 4234 56339 57721 79068 54890 23035 4609 468 PMC8120744__F4 Upregulated anti-angiogenic miR-424-5p in type 1 diabetes (model of subclinical cardiovascular disease) correlates with endothelial progenitor cells, CXCR1/2 and other parameters of vascular health 3643 4513 7424 595 3579 7422 958 3577 PMC8122702__F2 NRF2/KEAP1 Signaling Pathway in Cancer Metabolism 9817 8452 9978 PMC8123284__F3 Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis 7018 23657 6520 2879 PMC8123608__F3 Autoinflammatory Features in Gouty Arthritis 7099 929 8651 133522 5229 3638 23452 53942 114548 335 345 149233 PMC8124706__F1 Targeting BRAF and RAS in Colorectal Cancer 1956 2885 6654 4609 3725 PMC8125460__F2 From Channels to Canonical Wnt Signaling: A Pathological Perspective 1499 4609 2932 358 8312 324 PMC8126329__F1 Analysis of the Protein–Protein Interaction Network Identifying c-Met as a Target of Gigantol in the Suppression of Lung Cancer Metastasis 5098 9620 640 8502 56129 2239 56288 1824 11187 64098 9752 79633 421 5318 3688 3915 28513 23499 5361 1826 3913 10178 10232 3912 PMC8126563__F1 Protein kinase CK2: a potential therapeutic target for diverse human diseases 5728 1499 7518 4361 9656 6774 3717 367 PMC8130467__F5 Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis 7450 59272 7113 4615 3383 6651 PMC8132202__F4 Risk prediction model of gene signatures in ovarian cancer through bagging of GA-XGBoost models 10451 94122 54843 6038 1462 55022 80310 1363 5125 203447 4969 55137 79625 84624 4477 2690 4239 64344 55384 3487 3488 3624 8821 PMC8134663__F2 Unraveling the Role of the Apical Papilla During Dental Root Maturation 2260 2263 6657 79923 6469 64399 4782 1834 860 89780 54361 147111 4040 4041 1499 324 PMC8134850__F7 Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NFKB and TGFB1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling 4089 4087 4088 4313 4318 7076 7077 7124 1728 847 9817 PMC8136131__F10 Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway 25975 57758 3490 4920 1809 9871 7351 8817 348 4320 25999 5157 1281 9518 6382 7291 165 4322 7490 1948 7099 1956 3397 7048 5196 5468 185 2264 28964 6926 6909 10395 5607 2878 23218 8406 7466 5295 154 2767 PMC8137523__F6 Rational combinations enhancing the effects of statins at the mitochondria 19 1723 2879 581 596 PMC8138161__F1 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway 2475 8408 9706 55626 7405 10533 64422 9140 9474 3920 3916 PMC8142022__F4 Metabolism and cell signaling in ferroptosis 4771 999 2182 8314 PMC8143539__F3 Using Pharmacogenetics of Direct Oral Anticoagulants to Predict Changes in Their Pharmacokinetics and the Risk of Adverse Drug Reactions 3240 1576 1066 PMC8144021__F1 Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction 64806 90865 85480 PMC8145791__F14 TRPC channel-derived calcium fluxes differentially regulate ATP and flow–induced activation of eNOS 7223 7222 84876 PMC8147992__F2 Fibrotic Events in the Progression of Cholestatic Liver Disease 6608 3714 2735 2736 3280 8321 1499 PMC8148105__F1 IDARE2—Simultaneous Visualisation of Multiomics Data in Cytoscape 57678 5053 55326 1050 717 727 5468 718 729 PMC8150799__F4 Physiological and Pathological Inflammation Induced by Antibodies and Pentraxins 1401 208 7124 6850 29110 3663 3553 PMC8151573__F1 Oncogenesis, Microenvironment Modulation and Clinical Potentiality of FAP in Glioblastoma: Lessons Learned from Other Solid Tumors 7040 2191 6469 6347 5728 6774 PMC8151866__F1 BANK1 in B Cell Signaling and Disease 613 6714 51284 4067 640 4615 55024 7189 3665 1540 3663 57379 PMC8154588__F5 Synthetic lethal interactions in SWI/SNF-mutant cancers with chemical tools for targeted cancer therapy 1021 1019 60 6595 545 6714 6597 2146 2729 6760 6598 84678 10013 57492 65980 11065 4193 4194 PMC8156939__F2 PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders 3479 3667 572 4193 175 5728 5163 7249 7248 4609 PMC8157020__F2 Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer 3569 3717 367 6774 2535 7474 2534 10006 PMC8157545__F1 Efficacy of BRAF and MEK Inhibition in Patients with BRAF-Mutant Advanced Melanoma and Germline CDKN2A Pathogenic Variants 4193 4893 673 1021 1019 PMC8160296__F5 Circular RNAs in Hepatocellular Carcinoma: Emerging Functions to Clinical Significances 637 581 5728 572 PMC8160634__F4 Potential Role for HUWE1 in Modulating Cisplatin Sensitivity 472 150365 3066 10075 PMC8161379__F2 Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy 8408 9706 9776 10715 65018 PMC8162686__F2 Peg3 downstream genes involved in major metabolic pathways 669 47 3417 3420 8803 2194 3156 PMC8165182__F1 An Overview of Lung Cancer in Women and the Impact of Estrogen in Lung Carcinogenesis and Lung Cancer Treatment 6714 1956 7852 999 3480 6387 PMC8165220__F3 Rac1, A Potential Target for Tumor Therapy 11021 998 3931 1499 999 5879 2064 7410 644192 5357 8826 83478 11339 659 3725 9475 6405 10512 8828 5058 5062 4313 PMC8168947__F2 Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target 4485 5163 51684 6608 2735 324 1499 4609 5347 PMC8169545__F2 Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015–2020 updates 102 6868 348 4023 6850 PMC8169786__F1 Recommendations for Vaccination in Children with Atopic Dermatitis Treated with Dupilumab: A Consensus Meeting, 2020 941 942 940 920 6775 6778 2625 613 3566 PMC8170084__F1 Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease 64783 57721 23091 1999 25962 9589 54915 253943 91746 79068 3183 3181 51441 PMC8170620__F1 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection 100302274 9532 4615 7189 9021 6774 PMC8172602__F9 Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet 5550 2194 283871 23411 PMC8172903__F2 STING1 network regulates autophagy and cell death 340061 2475 29110 8408 10533 9474 26100 8878 PMC8175487__F8 Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation 2876 3020 1017 5465 5163 2885 PMC8175905__F5 Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma 2475 1499 999 PMC8176847__F1 Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications 4193 581 836 842 331 27429 PMC8180168__F1 Stem cells and exosomes: promising candidates for necrotizing enterocolitis therapy 4513 1499 7033 4583 PMC8182896__F2 Ang/Tie signalling pathway under physiological and pathophysiological conditions 8826 7075 3383 7412 1003 2885 5879 7072 2308 7422 PMC8184946__F8 Graph indicates the mechanisms of how TRPM2 promote pancreatic cancer proliferation and tumorigenesis 7226 2002 595 4208 PMC8185510__F6 Autophagy inhibition and microRNA-199a-5p upregulation in paclitaxel-resistant A549/T lung cancer cells 2475 29904 9474 PMC8185927__F1 Overcoming the UCB HSCs –Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGFB Signaling Pathways 7535 4087 4088 4089 3479 947 2885 7173 3569 5728 5163 PMC8185945__F9a In Parkinson's patient-derived dopamine neurons, the triplication of Alpha-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition 5599 1813 2770 6714 5879 7410 998 4294 5601 5602 1432 5170 5609 5608 5335 3725 2353 627 6571 5923 10125 3708 6464 5594 7867 5605 9261 2885 6654 2549 5604 5595 PMC8185986__F2 F ig . 2.Mϕ regulation of PMN chemotaxis 3579 156 2869 7099 PMC8187207__F9 Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity 166929 5091 1605 259230 PMC8187562__F13 Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis 3717 6774 2475 5728 2308 3280 596 581 4851 23411 664 PMC8187637__F2 Canonical stress granule assembly pathway 83939 3178 10949 2130 3181 10146 PMC8189631__F6 NRF2 induction via FAM129B in mutant BRAF cells 9817 4097 2729 2730 1728 5682 51371 5888 PMC8189684__F3 MEScan: a powerful statistical framework for genome-scale mutual exclusivity analysis of cancer mutations 4780 9817 5728 1956 5290 3417 1029 4869 8243 2475 4193 7157 4763 672 51755 PMC8194146__F2 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer 4485 9113 26524 60485 55233 92597 PMC8194146__F3 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer 10413 2305 4485 9113 26524 PMC8194146__F5 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer 81029 55272 400500 1499 89780 693198 23558 1956 2736 5163 9611 6497 PMC8196896__F2 Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections 7124 8717 7186 8737 8772 11035 64750 PMC8198029__F4 SARS-CoV-2-Induced Gut Microbiome Dysbiosis: Implications for Colorectal Cancer 7099 3605 7097 3596 201633 4773 3600 10148 3091 3558 3606 3458 4843 3569 3565 3586 2475 5743 6774 4088 5465 7124 4790 5970 1236 50616 3552 8767 23643 7096 6772 7157 54106 3146 4335 4318 4792 7184 2033 2908 3627 5468 3661 142 960 8517 PMC8198482__F2 Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis 3156 19 348 4035 3949 PMC8199207__F1 Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers 920 1499 8205 942 941 940 3586 PMC8200556__F2 Genetic Determinants Highlight the Existence of Shared Etiopathogenetic Mechanisms Characterizing Age-Related Macular Degeneration and Neurodegenerative Disorders 348 387715 149233 4282 102465477 PMC8201612__F2 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand 3479 3667 6009 7249 7248 5163 64798 2475 64223 253260 2932 1998 PMC8203325__F1 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges 4041 1499 2932 324 2316 387 23002 PMC8204019__F4 Radiation Resistance: A Matter of Transcription Factors 1956 9817 1728 2879 2729 4851 3280 PMC8204249__F4 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms 7173 4352 3717 5970 2322 1021 7124 6279 4615 3654 51135 PMC8209385__F5 Identification of Methylation-Regulated Differentially Expressed Genes and Related Pathways in Hepatocellular Carcinoma: A Study Based on TCGA Database and Bioinformatics Analysis 5020 3363 6425 4094 4291 59345 5734 8519 9134 2475 8325 3662 2625 9314 5880 30009 6615 4313 3400 7043 2944 3908 7056 3039 1378 PMC8209548__F8 Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix Compaction 5879 998 5058 2316 PMC8210242__F4 Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer 472 545 675 672 5888 PMC8213731__F8 Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model 780 4921 4087 4088 4089 PMC8214274__F2 Histone dynamics during DNA replication stress 545 84126 23064 6050 1660 55183 9716 648 6045 2177 7150 4172 4174 4173 4176 4175 4171 5888 4361 1763 9156 353497 51426 641 675 PMC8214965__F5 姜黄素通过Wnt/Beta-catenin信号通路诱导人晶状体上皮细胞的凋亡和细胞周期阻滞 324 100187761 1499 4118 891 983 PMC8216017__F1 CXCL12 in Kidney Diseases: A Friend or Foe? 6387 6469 7852 PMC8217106__F4 Direct Targeting of Beta-Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives 51176 999 6925 324 PMC8218021__F3 Cross-Links of Endoplasmic Reticulum Stress, Autophagy, and Neurodegeneration in Parkinson’s Disease 596 9474 83734 11337 64422 468 55054 9140 4077 10533 1612 7186 2308 PMC8219969__F1 Promising Future of Ferroptosis in Tumor Therapy 6520 23657 2879 468 7037 PMC8220134__F6 Early Growth Response Family Members 1–4 in Prognostic Value of Breast Cancer 3212 1961 5243 4775 4664 3726 2353 1960 9592 4773 969 1051 6853 1959 1958 4772 3164 4665 9518 54625 2208 3972 PMC8220211__F3 JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment 3717 3595 652070 6775 PMC8220211__F6 JAK/STAT-Dependent Chimeric Antigen Receptor (CAR) Expression: A Design Benefiting From a Dual AND/OR Gate Aiming to Increase Specificity, Reduce Tumor Escape and Affect Tumor Microenvironment 6775 3595 652070 PMC8221367__F1 Canonical Wnt Signaling Pathway and Tcf1 999 1499 324 2932 8313 4040 4041 PMC8222665__F3 Tumor-Associated Macrophages: A Potential Target for Cancer Therapy 6347 729230 7852 2920 6387 8205 140885 961 958 PMC8222783__F4 Resistance Mutations to BTK Inhibitors Originate From the NFKB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway 6850 8915 2534 640 7441 974 973 4067 84433 10892 29760 5336 4615 51135 695 7189 3707 930 4893 3845 673 2782 2475 PMC8223745__F1 Current Challenges and Future Perspectives of Renal Tubular Dysfunction in Diabetic Kidney Disease 1386 3383 3146 7097 7099 4615 3654 51135 3716 3717 6772 6774 55669 1316 6446 PMC8225795__F3 Comparison of genetic alterations of signaling pathways in AFPGC and TCGA-GC 1956 2260 2263 4609 4763 2065 1021 1019 5925 7422 2064 5604 595 1030 1029 898 5728 4193 7157 7249 472 545 2066 2033 208 2475 675 672 4170 5292 PMC8226175__F1 Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy 22954 8178 8405 51132 51366 10075 6047 146330 4609 57646 57602 8975 7874 57695 23326 29843 PMC8226666__F1 Hippo Pathway: A Master Regulatory Network Important in Cancer 6010 4485 6714 PMC8229527__F1 NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications 7409 5336 1611 3717 PMC8231117__F2 Irisin in Cancer Disease 6774 999 1000 PMC8231866__F1 Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25 64802 51547 23411 51548 142 10039 10038 10135 23057 10478 22933 92014 349565 23410 23409 23408 PMC8232320__F1 Monogenic Autoinflammatory Diseases: State of the Art and Future Perspectives 3553 4598 828 114548 147945 3606 7099 64127 81858 90268 5422 79621 84153 11277 6611 115004 PMC8235734__F4 Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression 729230 6347 7852 6387 8205 51284 1435 961 PMC8236093__F1 Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS 2358 59352 2861 PMC8236857__F2 Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead 6420 4613 4149 5727 8190 4609 PMC8241721__F2 Heme oxygenase 1: a novel oncogene in multiple gynecological cancers 9817 581 6935 PMC8243426__F1 Phase II study of the PI3K inhibitor copanlisib in combination with the anti-CD20 monoclonal antibody rituximab for patients with marginal zone lymphoma: treatment rationale and protocol design of the COUP-1 trial 613 4067 695 6850 2475 PMC8245914__F10 HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial–mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/Beta-catenin signaling activation 999 4040 4041 1499 324 2932 PMC8253500__F4 Comprehensive Analysis of lncRNA and miRNA Regulatory Network Reveals Potential Prognostic Non-coding RNA Involved in Breast Cancer Progression 847 7754 347746 477 6517 284276 401093 83439 23268 1285 57061 79804 650623 PMC8255676__F1 Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs 81539 2744 23657 2937 8031 5212 2879 875 4015 2182 PMC8256367__F3 How Transmembrane Inner Ear (TMIE) plays role in the auditory system: A mystery to us 29899 117532 117531 259236 PMC8257365__F1 Dietary Antioxidants in p53-Mediated Cancer Chemoprevention and Tumor Suppression 637 581 64065 PMC8257864__F7 Comprehensive analysis of DNA methylation and gene expression profiles in gestational diabetes mellitus 51144 5054 8491 84919 4199 1806 2766 594 6648 1847 5352 5062 PMC8259786__F2 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease 28514 54567 10683 182 3516 1948 100188776 1026 PMC8260388__F3 Cellular signaling cross-talk between different cardiac cell populations: an insight into the role of exosomes in the heart diseases and therapy 59272 7248 2475 8651 PMC8261751__F2 Coronavirus disease and the cardiovascular system: a narrative review of the mechanisms of injury and management implications 59272 1636 367 PMC8261853__F2 Host Modulation and Treatment of Periodontal Disease 3716 7124 3570 920 2932 1499 6097 PMC8262738__F3 Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics 2534 864 1462 7351 1380 4939 931 3561 8205 81552 4049 2359 11119 355 6402 962 695 11118 2885 3003 6850 3133 3384 3001 4055 27040 11262 914 8741 4791 6295 916 2841 3820 929 6362 4216 752 3702 5199 7124 2057 915 PMC8262738__F4 Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics 1 1493 641638 2534 3932 1236 3561 25 10333 729230 2597 PMC8263639__F6 Tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy 2885 2549 5728 7249 7248 6009 331 253260 572 596 2932 4170 PMC8263687__F8 Novel mechanism driving poor-prognostic gastric cancer: overexpression of the transcription factor Krüppel-like factor 16 promotes growth and metastasis of gastric cancer through regulating the Notch pathway 83855 8076 1017 1499 1000 999 PMC8268128__F2 Adipose Tissue-Derived Extracellular Vesicles and the Tumor Microenvironment: Revisiting the Hallmarks of Cancer 23127 1499 6774 7874 7428 6662 6347 7015 7124 4314 472 PMC8268320__F1 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? 7939 4089 4087 4088 619501 5045 7018 857 50507 1499 1956 6010 PMC8269279__F6 Roles of Pseudophosphatases in Disease 55294 6815 1000 6935 999 92235 10659 PMC8269281__F1 Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis 85480 83737 4803 90865 2925 6761 PMC8270677__F4 Replication Stress Response on a Narrow Path Between Genomic Instability and Inflammation 11277 5888 80198 4361 PMC8271933__F1 Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products 4193 596 5728 331 5163 7249 7248 6009 PMC8273970__F10 EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway 444 9775 693184 27161 9480 9839 999 7422 PMC8275186__F1 Coordinated Cut and Bypass: Replication of Interstrand Crosslink-Containing DNA 2177 55215 57697 3398 56852 5111 PMC8276205__F3 PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury 2475 5335 7535 6774 50943 PMC8276315__F8 Small-molecule modulators of INAVA cytosolic condensate and cell–cell junction assemblies 55765 7189 64127 2475 PMC8276974__F2 Both calcium channel signaling and ITIM containing receptor signaling are involved in leukemia progression by binding to and activating the Ca2+/calmodulin dependent protein kinase family 91653 6774 1499 PMC8278527__F7 SFRP5 inhibits melanin synthesis of melanocytes in vitiligo by suppressing the Wnt/Beta-catenin signaling 4040 4041 1499 324 2932 4286 6425 PMC8278622__F1 Setting the pick: Can PI3K inhibitors circumvent CDK 4/6 inhibitor resistance? 5925 595 1021 1019 6009 7249 5728 2932 5163 PMC8280825__F1 Mitochondrial apoptosis pathway and opportunities for pharmacological inhibition 581 2021 87178 7417 4976 7416 115004 114548 PMC8282711__F1 One Carbon Metabolism and Early Development: A Diet-Dependent Destiny 27232 635 100188776 875 1491 55349 4548 4552 1103 4524 5091 10400 4522 10797 6470 1719 7298 907 PMC8283805__F2 Comparison of COVID-19 and Lung Cancer via Reactive Oxygen Species Signaling 1950 1956 6868 6774 2475 2000 PMC8288800__F3 Long noncoding RNAs regulate metastasis via various pathways using diverse mechanisms 2475 1499 4609 6934 101805488 283131 999 3720 2146 55384 100124700 400500 9839 6935 100302692 3691 378938 283120 441951 647979 3170 2932 57291 105416157 7503 PMC8289457__F6 Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment 658 10121 64750 57154 4092 4091 2280 3397 3398 3399 659 387 25932 2932 1499 5879 PMC8289790__F1 Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment 2475 6774 4089 4087 4088 3091 5465 50943 3586 PMC8289790__F2 Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment 50943 4088 4089 920 1374 2475 5728 PMC8290582__F3 Alpha- and Beta-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease 572 8139 5894 3725 2353 3486 999 2885 6935 4087 4089 7049 PMC8292865__F2 Epigenetically inactivated RASSF1A as a tumor biomarker 64112 581 4485 1616 890 991 324 PMC8293491__F6 Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease 5162 5160 59345 55970 54331 5507 10663 8569 29108 596 5610 4772 6348 5260 4973 2319 1965 5601 8411 1524 4283 5295 6387 861 1978 3937 4170 23175 4688 1977 4775 3627 5573 4893 4214 10725 8743 6772 4000 5579 9180 7037 6850 3685 3845 5058 2885 7409 30009 5829 4794 3655 3479 7048 2833 3516 8312 3455 6775 7074 71 6774 5209 5155 1385 7070 5170 4478 4853 10163 7529 2932 7046 6464 894 399 3481 4090 PMC8295685__F1 Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases 374654 51684 2737 2736 6608 5727 6469 PMC8300159__F1 Crossroads between Zinc and Steroidal Implant-Induced Growth of Beef Cattle 2852 1839 4318 4313 1956 3479 3480 5163 PMC8301018__F5 3H-1,2-Dithiole-3-Thione Protects Lens Epithelial Cells against Fructose-Induced Epithelial-Mesenchymal Transition via Activation of AMPK to Eliminate AKR1B1-Induced Oxidative Stress in Diabetes Mellitus 999 231 6648 1000 4318 PMC8301761__F1 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer 3579 3577 3791 3082 PMC8301761__F2 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer 5728 100187761 5163 5266 7248 8821 7249 6009 PMC8301761__F4 Molecular Landscape Influencing Prognoses of Epithelial Ovarian Cancer 8658 4040 4041 2932 1499 324 999 PMC8303858__F4 Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2 4879 5972 4313 999 5045 7045 59272 8862 7422 3091 7113 102 3630 4318 3458 8074 6517 1906 PMC8304822__F1 Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer 58525 5163 5728 PMC8305863__F2 Of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy 64127 3606 324 3661 29110 4615 7189 115004 3665 7099 54106 920 613 PMC8306115__F3 Ciliary Signalling and Mechanotransduction in the Pathophysiology of Craniosynostosis 51715 2737 3549 6608 2121 57728 57539 112752 9742 55764 51259 4750 2316 8318 79648 9702 153241 1431 259266 PMC8307416__F5 Identification and Roles of miR-29b-1-3p and miR29a-3p-Regulated and Non-Regulated lncRNAs in Endocrine-Sensitive and Resistant Breast Cancer Cells 3398 3399 6788 652995 6910 1499 4086 4087 4089 1909 4088 79002 6657 25859 860 688 5077 5371 3689 2625 2305 79923 595 PMC8308291__F1 Omega-3 Supplementation and Heart Disease: A Population-Based Diet by Gene Analysis of Clinical Trial Outcomes 2717 100 9415 60481 3992 54898 95 4015 PMC8310438__F1 Corrigendum to “Expression and Gene Regulation Network of Metabolic Enzyme Phosphoglycerate Mutase Enzyme 1 in Breast Cancer Based on Data Mining” 4193 3028 5214 5315 5547 3939 5224 1147 2597 57103 2821 7298 441531 226 669 7167 1173 PMC8310495__F1 Genetic Determinants of Paget’s Disease of Bone 81501 79890 3466 5371 647087 7189 23165 1540 10133 5216 57592 PMC8310949__F3 WNT3A rs752107(C > T) Polymorphism Is Associated With an Increased Risk of Essential Hypertension and Related Cardiovascular Diseases 4040 4041 2487 324 2932 1499 PMC8313795__F1 Chitosan derivatives: A suggestive evaluation for novel inhibitor discovery against wild type and variants of SARS-CoV-2 virus 59272 7113 5045 PMC8316205__F5 Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis 3206 3207 3170 2288 5640 1950 10140 10857 10424 PMC8319838__F5 Temozolomide resistance in glioblastoma - a comprehensive review 6774 2475 472 8408 7494 PMC8320431__F1 Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis 4087 4088 156 1901 3579 PMC8321875__F4 Neuroprotective Potential of Ellagic Acid: A Critical Review 9817 3667 5728 5163 PMC8323716__F1 Aberration of EZH2 signaling in cancer 4851 113791 6095 367 2002 6774 1643 PMC8323830__F2 Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy 7518 672 1763 9156 675 5893 5888 PMC8324678__F3 Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD 80339 123 79143 53345 PMC8326121__F1 Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives 388796 6015 5888 4841 PMC8326125__F8 TNFA augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell 2833 3627 387 PMC8327900__F1a What Are the Clinical and Systemic Results of Periodontitis Treatment in Obese Individuals? 3643 5163 51094 79602 26060 5465 PMC8328821__F3 NUMB/NUMB isoforms in cancer stem cells 2060 102 6868 1024 182 3714 8650 23462 3280 4193 1647 7248 5728 572 PMC8329443__F3 Vital Roles of LINC00662 in Human Cancers 148189 100874185 9113 4485 60485 122786 PMC8329661__F5 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? 3845 5728 4513 PMC8335161__F2 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer 596 101154753 22863 494333 9140 10533 9474 83734 718 735 727 730 729 8408 9776 255082 64798 64223 9675 2475 64422 4077 PMC8335161__F3 Impact of lncRNAs and miRNAs on Apoptosis in Lung Cancer 641518 51352 80307 4088 6659 5728 1950 654434 2932 1956 1499 51176 3371 2146 4040 4041 100126309 339201 PMC8336005__F3 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions 1499 999 2932 4040 4041 324 8161 1283 PMC8346253__F1 Distinct Signaling Pathways Distinguish in vivo From in vitro Growth in Murine Ovarian Follicle Activation and Maturation 4280 5728 5163 2475 PMC8346999__F1 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases 123803 55093 84890 11101 197131 23304 23352 51366 PMC8347170__F2 Autoimmune Responses in Oncology: Causes and Significance 942 941 940 PMC8348198__F3a R-loop modulated epigenetic regulation in T helper cells mechanistically associates coronary artery disease and non-small cell lung cancer 5594 596 5595 3480 5290 5605 2885 578 6175 673 5170 3845 1950 650 6654 207 11186 7157 10344 7422 90865 2597 1956 4282 246778 112744 6374 7039 3587 6387 1234 6364 1232 3600 10135 567 6356 3554 6354 3605 1524 6346 1237 5008 2920 959 1233 729230 2919 1437 1435 3579 6357 59067 3596 6368 2921 3568 10673 3588 7292 3567 7124 3627 3576 6347 6369 1440 3553 6348 8743 3557 3552 6359 3603 1431 6352 6355 27189 6360 PMC8348732__F4 Post-Translational Acetylation and Deacetylation of Signaling Proteins and Transcription Factors after Cerebral Ischemia: Facts and Hypotheses 10013 4193 23411 2932 4149 2002 1869 22933 8841 PMC8350333__F8 Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localization 3280 3642 595 4221 PMC8350857__F2 Promoting Effect of Traumatic Brain Injury on the Incidence and Progression of Glioma: A Review of Clinical and Experimental Research 2056 664 143686 3297 2475 2932 1499 1956 2627 PMC8351231__F2 The Hippo signalling pathway 4609 374 558 64866 6714 4771 60485 4485 9686 5784 PMC8351522__F4 Biomarkers and targets of mitochondrial dynamics 4541 708 4942 4193 5053 64863 260431 PMC8352569__F3 DNA Methylation of PGC-1A Is Associated With Elevated mtDNA Copy Number and Altered Urinary Metabolites in Autism Spectrum Disorder 2551 4899 30968 4976 9927 51024 PMC8353059__F3 Emerging Role of PD-1 in the Central Nervous System and Brain Diseases 3716 3717 6772 3718 6778 PMC8353313__F6 Coeloglossum viride var. bracteatum extract attenuates staurosporine induced neurotoxicity by restoring the FGF2-PI3K/Akt signaling axis and Dnmt3 2247 836 1788 1789 1356 PMC8353397__F9 Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis 7852 3725 4284 27035 9475 PMC8355044__F1 Functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy 960 7099 1956 5178 2475 387 7422 10399 PMC8355560__F2 An Overview of Novel Agents for Cervical Cancer Treatment by Inducing Apoptosis: Emerging Drugs Ongoing Clinical Trials and Preclinical Studies 60674 6476 4851 6774 355 6696 472 1956 3717 4436 2475 3146 PMC8357504__F3 Genome-Wide Expression Difference of MicroRNAs in Basal Cell Carcinoma 7157 581 51426 1499 2737 6608 1643 650 2932 578 1857 PMC8362831__F1 Tumor Growth in the High Frequency Medulloblastoma Mouse Model Ptch1+/−/Tis21KO Has a Specific Activation Signature of the PI3K/AKT/mTOR Pathway and Is Counteracted by the PI3K Inhibitor MEN1611 80310 7852 5159 3579 6714 7076 2475 23049 64798 5728 23235 10670 8661 5727 PMC8365911__F4 Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants 9935 5087 79875 64061 79658 11214 4756 25777 3206 51562 79738 292 55740 23500 388 8850 4792 4736 6206 8780 10810 10365 2487 5757 2113 1647 57447 10000 51422 4172 267 55920 4609 2597 1152 7301 928 978 2022 6541 2686 3074 9536 28984 4322 1486 1471 1271 5037 30845 3909 8038 3490 2934 8614 316 83660 3487 3489 1577 57488 55214 165 8515 10231 PMC8366450__F5 Human CPPED1 belongs to calcineurin‐like metallophosphoesterase superfamily and dephosphorylates PI3K‐AKT pathway component PAK4 55313 10298 5728 5163 207 5164 3611 23035 PMC8367322__F4 LncRNA BANCR in Human Cancers: An Updated Review 7124 6654 2885 387 4312 1000 999 100885775 PMC8368762__F1 Pyroptosis in cardiovascular pathologies: Role of noncoding RNAs 22926 8737 11035 197259 90865 355 7124 8772 8717 114548 3606 2475 2879 PMC8372757__F4 Differential regulation of cerebral microvascular transcription by single and repetitive hypoxic conditioning 3656 7189 9988 285 6850 6714 7157 1026 2885 5163 PMC8375153__F1 Mechanisms of Sevoflurane-Induced Neuroinflammation 8651 9021 6778 PMC8375236__F2 ATM at the crossroads of reactive oxygen species and autophagy 993 995 472 128 5830 PMC8375236__F3 ATM at the crossroads of reactive oxygen species and autophagy 472 7157 128 7249 2475 5830 PMC8375270__F5 When Viruses Cross Developmental Pathways 3549 6469 2736 182 54567 8324 2735 55294 388585 54626 390992 57801 1499 2121 22943 3280 6608 PMC8380002__F6 Glucose metabolic crosstalk and regulation in brain function and diseases 4040 6009 89780 2932 7249 7248 7474 3091 4035 PMC8380478__F2 Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application 6366 355 9242 4088 1636 941 PMC8383365__F1 Pyroptosis at the forefront of anticancer immunity 22861 114548 147945 3553 9447 6010 79792 8737 8772 1687 55876 56169 284110 PMC8383754__F5 Identification of HIF-1A/VEGFA signaling pathway and transcription factors in Kashin-Beck disease by integrated bioinformatics analysis 389692 3727 7975 3726 2597 5579 4843 4846 2475 5970 5595 2353 7076 4780 7422 3725 596 3569 4097 3162 3458 5295 4778 1628 PMC8389199__F8 Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway 581 1728 2729 9817 PMC8389593__F5 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway 142 8081 1585 3283 PMC8391764__F2 Platelets, Not an Insignificant Player in Development of Allergic Asthma 196 90865 5196 627 4318 4313 969 85480 PMC8393346__F2 Risks and Function of Breast Cancer Susceptibility Alleles 10111 472 4683 580 11200 672 545 83990 675 5889 5892 79728 1111 7157 PMC8394995__F2 BRCAness as a Biomarker of Susceptibility to PARP Inhibitors in Glioblastoma Multiforme 50853 7429 1956 23030 9682 4609 5129 2475 545 472 5888 5728 1869 PMC8395232__F1 Mitochondria-Induced Immune Response as a Trigger for Neurodegeneration: A Pathogen from Within 3603 9447 3661 115004 29110 54106 6773 10379 PMC8395432__F6 SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection 7099 54106 7098 51284 51311 7113 59272 142 PMC8395475__F2 Adipose Tissue Dendritic Cells: Critical Regulators of Obesity-Induced Inflammation and Insulin Resistance 920 4321 2335 3596 3569 3458 PMC8395722__F2 Synthetic mRNAs; Their Analogue Caps and Contribution to Disease 4193 940 7248 7249 1612 596 PMC8396993__F1 Perspectives on Precision Medicine in Chronic Lymphocytic Leukemia: Targeting Recurrent Mutations—NOTCH1, SF3B1, MYD88, BIRC3 10683 54567 3714 102 4609 1026 441478 PMC8399750__F1 Nrf2 Pathway in Ischemic Stroke: A Review 9817 1728 8685 948 53342 4094 10241 8408 PMC8401259__F5 Immune Response and Apoptosis-Related Pathways Induced by Aeromonas schubertii Infection of Hybrid Snakehead (Channa maculata♀ × Channa argus♂) 7124 2242 8772 8717 7186 4615 637 572 839 836 840 842 100506742 581 472 PMC8403095__F1 Higher-order assemblies in immune signaling: supramolecular complexes and phase separation 4118 4615 51135 3656 3654 7099 8915 57506 10892 3661 613 3553 355 8772 PMC8405297__F6 Biological Activity, Hepatotoxicity, and Structure-Activity Relationship of Kavalactones and Flavokavins, the Two Main Bioactive Components in Kava (Piper methysticum) 1019 595 197358 2475 4313 4318 581 PMC8405392__F4 Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology 7124 213 5728 5788 5914 1636 7276 4314 4322 5599 26191 5743 7052 240 4792 5970 1991 154 3558 2100 4318 PMC8406474__F3 NRF2 signalling pathway: New insights and progress in the field of wound healing 2729 114548 23410 367 2475 9131 192111 9817 PMC8409023__F1 Targeting the tumor microenvironment in chronic lymphocytic leukemia 613 695 3702 6850 8205 930 PMC8413833__F8 Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas 4282 7078 1017 581 PMC8414384__F2 Hypoxia in inhibiting dendritic cells by VEGF signaling in tumor microenvironments: mechanism and application 7423 7422 8829 7424 4615 387 PMC8416109__F5 Advanced Computational Methodologies Used in the Discovery of New Natural Anticancer Compounds 1956 2885 2549 PMC8416724__F2 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy 4609 1499 6925 54814 6418 961 140885 325 PMC8416736__F2 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations 3553 102 7412 3383 PMC8417734__F4 Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases 6422 6423 6424 8322 8324 6425 4318 4313 2932 7471 7473 4775 1499 8313 89780 649 596 581 6010 5879 1401 51176 790 PMC8418074__F4 Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling 4851 2033 1387 64324 55294 472 1029 1956 2885 5728 1019 2475 4609 3725 7157 6774 5925 9817 8452 940 286887 3854 324 915 920 PMC8418153__F2 Ferroptosis: A Trigger of Proinflammatory State Progression to Immunogenicity in Necroinflammatory Disease 6520 2879 3658 3315 7018 PMC8418611__F4 Several signaling pathways regulated by circRNAs in osteoporosis 1499 4040 4041 324 2932 860 57154 4089 8717 7186 1616 4087 4088 64750 4092 4091 4086 650 PMC8419240__F5 Arsenic: Various species with different effects on cytochrome P450 regulation in humans 196 405 1543 PMC8419281__F2 An Update on Targeted Treatment of IgA Nephropathy: An Autoimmune Perspective 716 718 717 10747 727 729 730 PMC8419495__F4 Gene Expression Analysis Reveals Key Genes and Signalings Associated with the Prognosis of Prostate Cancer 6241 6865 10886 1910 1268 891 890 1909 1813 7272 6752 5733 995 6915 6790 2767 22953 8318 109 111 23236 2771 9630 PMC8422929__F1 Regulators of liver cancer stem cells 6657 79923 6926 9314 3082 23462 8312 6774 94241 100124700 29072 378938 PMC8424196__F4 Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease 56339 1840 151636 102 23220 196403 5867 3627 142 3659 PMC8425214__F3 Regulatory networks of the Hippo signaling pathway in cancer development 9113 4485 860 6714 29110 57506 PMC8425587__F1 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) 3845 6925 1499 3297 PMC8425587__F4 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) 8878 7124 7189 9314 PMC8428888__F2 Preimmune Recognition and Response to Microbial Metabolites 9817 9978 4094 PMC8429149__F1 IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore 7189 10454 23118 27179 27177 4615 7054 PMC8429807__F3 Smoking and the Pathophysiology of Peripheral Artery Disease 23411 23410 4353 3596 114548 83939 PMC8430223__F2 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases 10631 4040 2050 1493 860 PMC8430223__F3 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases 10631 468 83939 PMC8430758__F6 Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease 355 8772 572 596 2475 1977 4609 PMC8430824__F1 Ferroptosis and Synthetic Lethality Strategies 6303 27165 1803 1026 23657 6520 2879 7417 7419 PMC8431517__F4 Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout 3291 10919 1588 1586 1723 10682 10038 5465 1789 2100 5467 5915 2597 5468 6462 7442 56848 11200 367 978 100 7421 4860 5578 5771 5340 7099 1890 6095 5320 PMC8435612__F2 Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases 351 100379571 100862680 4137 7976 2932 100507533 283131 3569 3606 55384 PMC8435728__F4 RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report 1399 1398 23624 596 54205 842 6502 572 1956 2322 5747 10000 4792 5154 5155 2885 1856 4193 2475 6655 4609 4893 3265 3845 673 369 5595 2353 5900 4254 3815 PMC8438241__F7 Sec62 Regulates Endoplasmic Reticulum Stress and Autophagy Balance to Affect Foot-and-Mouth Disease Virus Replication 7095 22926 7494 7405 PMC8440965__F5 Acute Impacts of Different Types of Exercise on Circulating Alpha-Klotho Protein Levels 203 3479 3480 2475 6648 PMC8441355__F6 Protective effect of Salidroside on hypoxia‐related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways 3717 6774 1571 1728 PMC8444356__F2 Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target 2267 2475 999 1000 4321 1950 1956 142 PMC8446626__F2 Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis 2296 2475 999 7852 3091 PMC8446626__F3 Therapeutically Targeting Cancers That Overexpress FOXC1: A Transcriptional Driver of Cell Plasticity, Partial EMT, and Cancer Metastasis 4790 5970 2296 5300 1956 1950 2475 PMC8448888__F3 Clustering analysis of the SNOed proteins in ASD and AD mouse models 10814 4638 3717 10775 351 23394 320 2778 PMC8448888__F5 Suggested scheme of the SNO-dependent mTOR activation in the ASD and AD mouse models 5879 7481 11211 2932 51256 64798 7248 6009 7249 64223 6194 5163 9261 7189 185 PMC8450353__F7 Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19? 3569 7113 5163 6868 9261 7124 7098 4615 59272 PMC8450407__F3 TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease 3665 3661 3717 3659 3716 6772 6737 3663 10379 3660 6773 7297 3394 3662 54106 PMC8450498__F1 Structural Analysis of SARS-CoV-2 ORF8 Protein: Pathogenic and Therapeutic Implications 6388 1786 23765 22926 80267 55757 64374 51661 60681 54480 80213 8754 23071 4758 90161 8836 79586 126789 23646 5817 5327 5046 10577 5352 1291 3688 10525 79070 9510 54850 4015 9512 4884 79666 83729 PMC8452875__F1 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease 1628 1407 4783 406 9575 551 7432 PMC8455403__F7 Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance 367 5245 4899 6696 3484 3207 5241 1839 PMC8458965__F3 MAVS: A Two-Sided CARD Mediating Antiviral Innate Immune Signaling and Regulating Immune Homeostasis 54602 79671 29110 57506 2147 57762 5496 PMC8463184__F3 Idebenone-Activating Autophagic Degradation of Alpha-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson's Disease: A Network Pharmacological Approach 554 5140 6608 5664 5600 3551 2475 5294 5170 5599 890 5601 4193 9261 1269 207 1956 3717 1128 331 238 351 5293 1813 3062 1432 7018 367 208 2147 5290 2241 55851 23385 6850 51083 5591 5291 2194 4914 4889 1129 5515 5663 1017 5243 PMC8463317__F4 lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment 283120 1789 1017 1021 2146 400619 100188776 7472 100507632 5728 2475 400643 4615 104472715 PMC8463536__F4 Enzymatic activity of TIGAR 2539 5209 57103 669 PMC8465847__F1 Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer 1524 643 969 114836 3002 3902 9760 864 5551 PMC8465904__F4 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells 7808 324 2932 1499 355 581 637 4193 8772 PMC8469138__F3a Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis 916 27240 9047 917 10225 6775 5836 56253 10379 64108 3702 940 3932 8638 10666 919 915 7168 89 914 1493 88 7140 4703 7273 8557 7169 1535 960 3270 3663 8832 58191 PMC8469604__F6 Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing 9817 3162 1728 6647 6648 2512 2539 5163 7351 PMC8469693__F3 NFKB and Pancreatic Cancer; Chapter and Verse 3603 3550 613 4055 4050 5971 PMC8469693__F5 NFKB and Pancreatic Cancer; Chapter and Verse 7097 51311 54106 7099 10333 7100 51284 3656 3654 51135 7124 5966 8717 7186 23118 257397 5971 PMC8470960__F2 Effects of Intermittent Fasting on Brain and Cognitive Function 95 2475 627 PMC8471347__F3 NFKB Nucleolar Stress Response Pathway 5970 595 1019 27343 11201 PMC8471715__F2 Oxidative Stress, Testicular Inflammatory Pathways, and Male Reproduction 4615 4899 4025 2099 PMC8472352__F2 New Functions of Vav Family Proteins in Cardiovascular Biology, Skeletal Muscle, and the Nervous System 7410 6714 5879 5058 387 PMC8472588__F9 ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas 56940 3716 3662 4609 7297 6098 6774 9242 7157 3559 965 PMC8476812__F6 Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way 2002 4609 7852 4316 4313 4851 7124 2146 10365 864 1028 638 1027 7157 9687 2309 2296 5888 2354 4261 999 9021 8864 6477 4015 6659 PMC8478908__F2 TNFA/TNFR1 signaling activates necroptosis and triggers apoptosis and inflammation 23118 257397 7186 8717 8737 717 1540 355 8772 11035 197259 7097 7099 PMC8479066__F6 Receptor tyrosine kinase ROR1 ameliorates AB1–42 induced cytoskeletal instability and is regulated by the miR146a-NEAT1 nexus in Alzheimer’s disease 387 9475 4133 7054 PMC8481945__F2 Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy 6104 1499 4286 4609 5077 4781 4851 28514 2146 673 4088 4920 4804 1956 4087 4089 3159 558 PMC8483912__F3 Stingless Bee Propolis: New Insights for Anticancer Drugs 3479 3082 572 1950 5728 2475 983 1017 595 1026 1027 7157 PMC8486678__F1 Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19 59272 1514 7113 PMC8489073__F6 Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges 6790 1956 6654 4893 3265 2475 3667 3480 6615 3845 5979 6016 5728 4763 PMC8489222__F2 Targeting smooth muscle cell phenotypic switching in vascular disease 54790 6722 93649 3667 208 2627 PMC8489683__F1 Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node 2309 10135 7428 3091 7019 2308 4899 PMC8491218__F1 Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors 5979 1244 5078 174 287 84458 7273 7472 2239 7168 27161 PMC8491225__F1 Biological role of metabolic reprogramming in pancreatic cancer 2673 9945 3939 3099 3098 PMC8491225__F2 Biological role of metabolic reprogramming in pancreatic cancer 2806 2746 4190 4199 PMC8492102__F4 Unboxing the molecular modalities of mutagens in cancer 545 115004 29110 3659 PMC8492287__F6 Novel Identified Peptide Hormone “Metabolitin” Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway 355 5465 948 PMC8493254__F5 Proteome Modulation in Peripheral Blood Mononuclear Cells of Peste des Petits Ruminants Vaccinated Goats and Sheep 7706 3661 9636 64108 339390 3664 9618 259197 4803 79132 4599 1747 3434 3437 81030 7098 7099 PMC8496198__F7 PI3KG/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization 960 387 2549 2475 PMC8502484__F1 Parallels Between the Antiviral State and the Irradiated State 6772 6773 10379 57506 54106 4615 51311 51284 7189 3661 3665 7098 9447 115004 PMC8502826__F10 Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers 51266 122622 25898 5091 3242 6288 5950 4837 27329 55908 1050 2646 3263 3083 79783 50508 5004 8840 8714 54346 PMC8502912__F8 LPA1-mediated PKD2 activation promotes LPA-induced tissue factor expression via the p38A and JNK2 MAPK pathways in smooth muscle cells 5312 4018 5310 5311 7018 PMC8503804__F2 Circular RNA regulates the onset and progression of cancer through the mitogen-activated protein kinase signaling pathway 1956 5894 4615 7422 3149 84985 693122 2260 6928 PMC8504117__F2 Advances in the study of emodin: an update on pharmacological properties and mechanistic basis 4088 23411 64750 10716 4089 4087 6935 4851 57504 3280 23462 PMC8505973__F1 Resistance to Hypomethylating Agents in Myelodysplastic Syndrome and Acute Myeloid Leukemia From Clinical Data and Molecular Mechanism 978 1025 63899 1633 100187907 7189 7412 941 958 9242 942 940 PMC8506221__F5 Schematic molecular pathway of LE regarding ICAM-1 dan E-Cadherin expression 196 7099 3383 999 PMC8507033__F3 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining 3654 7189 6934 27250 10533 5728 2475 283120 2308 6774 PMC8507398__F10 Molecular biology of autoinflammatory diseases 8767 1540 64127 23118 10454 7189 114609 4615 51135 3654 90268 81858 8717 7186 7188 8737 PMC8507398__F9 Molecular biology of autoinflammatory diseases 8767 1540 10392 64127 23118 10454 7189 114609 4615 51135 3654 257397 90268 81858 8717 7186 7188 8737 PMC8507548__F1 Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis 114548 6774 7099 7474 6374 3579 PMC8507803__F2 Good Cholesterol Gone Bad? HDL and COVID-19 19 335 5444 55937 3931 1071 7038 9619 338 PMC8508623__F1 Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane 3643 4067 6850 PMC8508636__F1 RNA Modifications and Epigenetics in Modulation of Lung Cancer and Pulmonary Diseases 56339 378938 2539 7078 2305 23269 54890 51441 54915 253943 8661 1999 PMC8509312__F6 Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment 11113 3418 4118 23530 PMC8509327__SF2 Non-Canonical Wnt Signalling Pathways in Bone Biology 22881 4920 5879 998 387 PMC8509383__F2 Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved 596 284 999 1075 4015 10507 5163 5209 PMC8510467__F5 Systematic Review of the Biological Effects of Cordycepin 5163 7249 6009 253260 2475 64798 55615 9776 8408 PMC8511144__F7 Phenylephrine increases tear Cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway 5873 9545 3916 3920 5874 PMC8511446__F5 Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome 140885 387 5879 7409 2621 10461 PMC8511580__F1 Biological signaling networks related to PM10 & PM2.5 exposure inducing skin-related cellular processes and diseases 3728 5228 7057 5970 5154 847 2335 652 3624 6662 3725 1147 6319 6364 7422 5468 7157 650 1385 5624 653 3627 5765 2247 3172 9590 1956 4282 7052 8091 1906 5328 3861 6351 6347 1437 1440 3976 7431 9314 10468 9982 6374 2920 3371 3303 7076 4353 1958 10062 2778 7186 PMC8518101__F2 When to Measure Plasma Homocysteine and how to Place it in Context: The Homocystinurias 867 23624 868 100188776 PMC8525858__F7 Small-molecule Akt-activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2 7100 9817 5163 1728 PMC8531299__F1 FASN and the cell death decision circuitry controlled by the BCL-2 family 47 2194 637 90427 8739 638 572 666 581 PMC8533927__F1 Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers 3845 10413 6935 9817 5163 PMC8534120__F2 Sphingolipids in Hematopoiesis: Exploring Their Role in Lineage Commitment 5091 166929 259230 6610 6609 55512 55627 392275 9517 10558 427 56624 340485 55331 125981 56848 8877 10715 253782 91012 204219 29956 79603 123099 2531 130367 81537 8879 PMC8534127__F5 Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q 1827 940 8451 1642 51185 3559 10320 22806 3662 831 8111 823 PMC8534845__F1 Immunotherapy in Extensive-Stage Small Cell Lung Cancer 4609 472 545 6790 7465 5925 4760 91607 1869 2146 429 10683 6352 3627 PMC8535589__F1 Cell Death and Survival Pathways Involving ATM Protein Kinase 355 581 472 2932 22926 PMC8535999__F1 Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications 59272 8829 64398 PMC8536509__F2 MTORC1 by amino acids in mammalian cells: A general picture of recent advances 3479 55615 253260 64798 3667 2475 64223 5163 9776 8408 7942 6009 5337 PMC8536918__F1 Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy 1956 5728 5163 51684 6608 324 1499 4087 4089 4088 PMC8537037__F2 Abscopal Effect: A Review of Pre-Clinical and Clinical Advances 115004 3146 7099 941 1493 PMC8539140__F3 LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma 100124700 4485 9113 2146 100316868 378938 55000 595 332 PMC8540409__F6a Metabolomics Investigation of the Metabolic Changes of Raji B Lymphoma Cells Undergoing Apoptosis Induced by Zinc Ions 1956 2885 5335 56261 5091 10434 PMC8547127__F1 Tipping the balance: intricate roles of the complement system in disease and therapy 64478 124925 2271 1378 1604 718 2161 27202 5648 717 720 721 730 729 735 715 716 966 PMC8549349__F7 ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway 3688 7094 8515 PMC8549964__F3 Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model 6347 6354 5196 1435 8740 3624 729230 1234 2833 1439 1441 3590 8764 91 409 3717 3718 6714 3702 7409 387 6773 5293 23533 6093 9475 3551 5879 60 4688 4689 PMC8551632__F5 Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3: Potential Functions and Implications for Development and Disease 5970 1499 7422 PMC8555304__F3 Chemoprotective and chemosensitizing effects of apigenin on cancer therapy 572 150365 581 7124 9817 PMC8555376__F1 Race to stymie BTK: zanu zings 4067 613 6850 6774 2475 4615 3654 695 84433 8915 10892 3055 6387 7852 PMC8557215__F7 Schematic drawing of LPS function in PDAC 7099 4615 3929 PMC8557339__F4 Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis 4069 2896 5720 2670 4360 9636 30835 2810 10971 1440 51506 6275 7532 10871 7529 7533 7534 7531 822 54097 5037 721 5223 4151 84868 57823 720 5478 715 761 PMC8558079__F7 Signal Transduction and Molecular Regulation in Fatty Liver Disease 4771 154796 9686 4485 60485 9113 55233 387 PMC8560708__F3 Targeting DNA Damage Response Pathway in Ovarian Clear Cell Carcinoma 5888 545 472 7518 3981 8289 6790 5347 7153 PMC8561765__F7 Tea polyphenols alleviate hydrogen peroxide-induced oxidative stress damage through the Mst/Nrf2 axis and the Keap1/Nrf2/HO-1 pathway in murine RAW264.7 cells 4485 9817 847 4094 PMC8561869__F2 FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases 3479 5163 8471 3667 8660 PMC8568295__F9 Hub gene multi-factor regulatory network 7490 7421 3684 9314 6688 2359 3689 688 6670 719 6668 6667 861 PMC8569340__F3 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy 1950 673 1956 5728 2475 3458 3659 23476 PMC8569351__F2 FOXO1: a pivotal pioneer factor in oral squamous cell carcinoma 2308 4485 55170 4193 22863 64326 23411 6446 PMC8570367__F1 Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment 4199 2744 3417 PMC8573099__F7 Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule 5321 587 10449 64499 1491 2572 3098 51067 3613 2645 8637 3945 1738 10993 5053 3030 PMC8573439__F1 Mechanisms and pharmacological applications of ferroptosis: a narrative review 7018 55240 3315 3658 8031 10533 9474 2879 9817 6303 6541 6520 6510 3652 2643 10162 4015 PMC8574196__F3 ApoE and AB interaction 348 3949 4035 19 54209 PMC8576699__F6 Synergistic effect of chidamide and venetoclax on apoptosis in acute myeloid leukemia cells and its mechanism 3065 1017 9021 3717 6774 581 PMC8577929__F1 Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function 3569 9817 847 7249 8408 PMC8578102__F1 Transforming Growth FactorB and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment 4091 4092 4089 4087 4088 6497 7291 387 PMC8578384__F3 Candidate genes of SARS-CoV-2 gender susceptibility 3146 710 2638 7113 102 6351 6356 367 2028 59272 3661 7099 684 2623 54106 51284 PMC8579148__F4 Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease 9474 9776 8408 6714 3479 6009 7249 7248 1950 PMC8581311__F2 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment 8205 2099 1956 2260 PMC8581319__F1 Epithelial‐Mesenchymal Transition in colorectal cancer: Annexin A2 is caught in the crosshairs 999 1950 3082 6714 1072 302 3479 6774 PMC8583859__F2 Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy 114548 4513 948 920 7099 7097 3553 PMC8584071__F3 Epithelial to Mesenchymal Transition: A Challenging Playground for Translational Research. Current Models and Focus on TWIST1 Relevance and Gastrointestinal Cancers 2932 1499 6774 7291 3091 PMC8585665__F1 Major Ca2+-dependent pathways that could be affected by genes mutated in B-cell lymphomas (Table ) 355 6387 9294 7852 695 6850 933 89857 613 3707 973 974 4615 7099 54106 596 7976 286530 5728 PMC8586701__F5 Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway 1813 3725 836 7054 627 351 2353 5595 3845 1385 3479 1950 7124 4803 207 1432 847 5599 PMC8588021__F3 Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders 9817 1728 2729 3553 PMC8589435__F3 Canonical Wnt signalling is critical for ISC niche maintenance and is potentiated by Lgr5 8549 54894 324 100187761 4040 PMC8590218__F4 Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure 3929 7097 10333 5879 54472 114609 1513 7098 7189 7187 23118 5132 3659 3661 958 948 PMC8590447__F12 SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein 59272 4282 4854 PMC8591135__F1 Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems 7096 7097 4615 114609 10333 51135 22906 3656 7189 23118 257397 7100 81793 7099 7187 3665 29110 3661 51284 51311 54106 PMC8591223__F10 Low Expression of SLC7A11 Confers Drug Resistance and Worse Survival in Ovarian Cancer via Inhibition of Cell Autophagy as a Competing Endogenous RNA 3091 2475 7405 8408 9706 8678 440275 9821 29982 55014 9140 9474 3920 83452 PMC8593415__F8 Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target 8458 7298 10592 2475 4004 22800 207 7436 4092 282996 3908 4625 2192 PMC8599287__F7 USP25 Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Modulating the PI3K/AKT Pathway via Deubiquitinating PTEN 29761 983 5728 1019 PMC8599985__F1 Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function 1950 4803 1956 283131 2885 3667 2353 4609 3725 3579 3577 7297 3716 1399 3575 10365 1977 5163 5728 693218 6714 7248 7249 6009 PMC8602556__F1 Crosstalk Between ER Stress, Autophagy and Inflammation 22926 29110 83939 7186 22809 468 1388 10628 3661 114548 3553 PMC8603304__F1 Fungal cell wall components modulate our immune system 3596 114548 3553 7099 7124 2475 PMC8603450__F1 Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway 23657 6520 3934 4057 2182 55240 10162 7018 23327 9817 8544 10533 9474 8031 2879 587 PMC8603450__F2 Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway 7018 55240 3934 4057 23327 PMC8603464__F1 Regulatory role of the transforming growth factorB signaling pathway in the drug resistance of gastrointestinal cancers 9242 4092 4087 4088 4089 999 100133941 1000 7852 6935 6591 PMC8606660__F6 Intrinsic Mechanical Cues and Their Impact on Stem Cells and Embryogenesis 4771 4485 60485 26524 9113 55233 92597 387 860 27063 PMC8606765__F2 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells 114609 81793 4615 7096 7097 10333 54106 51284 7100 51135 3654 7189 7099 7187 3661 7098 PMC8607427__F3 Post-translational modifications of CDK5 and their biological roles in cancer 1017 274 1956 1020 6774 146956 10630 22974 2146 472 581 3925 3014 PMC8608404__F2 REV7 Controls Pathway Choice at Stalled Replication Forks 9319 51455 5111 353497 201973 PMC8608404__F4 Two models for coordination between TLS and DSB Repair by REV7 112441434 149840 9319 54537 PMC8615124__F3 Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression 3418 4190 3417 PMC8615515__F6 Vitamin-Containing Antioxidant Formulation Reduces Carcinogen-Induced DNA Damage through ATR/Chk1 Signaling in Bronchial Epithelial Cells In Vitro 545 316 672 PMC8615556__F1 miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma 187 5771 23326 3459 3460 3716 3717 6772 3479 3480 467 1499 567 5728 6351 PMC8615627__F2 LncRNAs: Novel Biomarkers for Pancreatic Cancer 283422 5894 2297 729082 7503 1950 2549 2885 6774 1956 652995 2309 56957 6009 7249 7248 60674 5728 55384 3716 3717 100124700 PMC8616136__F1 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy 22943 89780 7480 4040 4041 2932 1499 324 PMC8616169__F4 Oncogenic KRAS: Signaling and Drug Resistance 1950 1956 3845 2475 PMC8616288__F3 FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance 572 581 4193 3082 4088 2475 999 1000 PMC8616420__F3 Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer 355 8772 841 836 1263 5728 3091 2475 PMC8617942__F1 Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus 2308 3643 3630 3717 181 5163 5443 2475 PMC8618147__F6 Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of Disease 6772 6773 59272 7187 10379 7942 3553 114548 PMC8618769__F2 Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases 19 23621 9619 29881 64241 64240 PMC8621388__F1 Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands 1956 8772 7157 581 3099 2475 6774 2885 574461 PMC8621778__F1 Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases 1499 6259 4041 4040 324 2932 81839 57216 387 23002 PMC8623546__F11 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease 284086 84126 545 5888 PMC8624812__F3 Probiotics Regulating Inflammation via NLRP3 Inflammasome Modulation: A Potential Therapeutic Approach for COVID-19 3553 79792 114548 59272 140609 7113 PMC8624911__F1 Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO 7099 4615 3661 3663 6772 6778 6774 3662 3627 4360 PMC8627637__F1 Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration 8452 9817 2932 2534 8454 PMC8629365__F2 Schematic presentation of local translation regulation in dendritic spines of glutamatergic synapses of hippocampal pyramidal cells in response to synapse stimulation 7249 7248 6009 1977 3265 5894 PMC8630372__F1 Clinical Development of AKT Inhibitors and Associated Predictive Biomarkers to Guide Patient Treatment in Cancer Medicine 2885 5295 3845 5290 5728 7248 5163 7249 253260 2475 64798 6009 PMC8631517__F9 EMS1/DLL4-Notch Signaling Axis Augments Cell Cycle-Mediated Tumorigenesis and Progress in Human Adrenocortical Carcinoma 54567 11082 983 PMC8631789__F5 Overt Acute Hepatitis B Deteriorates in Females: Destructive Immunity With an Exaggerated Interleukin-17 Pathway 6965 3458 3565 3466 920 PMC8632547__F1 Hippo Signaling Pathway: The Trader of Tumor Microenvironment 60485 9344 51347 57551 4771 9113 55233 9686 4485 PMC8632547__F2 Hippo Signaling Pathway: The Trader of Tumor Microenvironment 6714 5163 9113 26524 6010 PMC8633417__F1 Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis 4843 7124 6774 3606 4583 PMC8633656__F1 Interleukin-17 family members in health and disease 84818 7189 6850 10682 55540 132014 22918 PMC8634476__F1 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients 7423 7422 7424 54567 5728 5163 8829 4087 4088 7249 7248 2475 572 PMC8634476__F2 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients 4040 4041 1499 324 4920 6259 6010 PMC8634653__F2 Integrins in Gastrointestinal Cancer Metastasis 5340 207 10000 208 2885 7939 4087 4088 1015 1950 1956 2475 PMC8638098__F5 Gene regulatory networks analysis of muscle-invasive bladder cancer subtypes using differential graphical model 2833 4050 1230 8744 7043 6352 7048 3626 3627 84818 3575 7066 659 83729 3586 656 2056 8794 10663 392255 653 2826 3439 3456 3598 2689 27189 6359 651 1440 4049 84957 133396 1441 7040 4838 3623 51561 6354 3953 23529 8741 6368 1270 5008 27177 970 1439 7042 27190 5473 3977 8807 6346 3563 57007 64806 10344 2661 85480 6366 1896 958 353500 652 3581 2690 3467 6364 6367 3560 1438 1435 53833 3594 1237 7292 2660 2829 6846 6370 6351 PMC8640817__F1 Targeting ferroptosis for cancer therapy: iron metabolism and anticancer immunity 2182 10162 2879 PMC8650160__F2 RAD52: Paradigm of Synthetic Lethality and New Developments 5111 5888 79915 6596 50485 5893 80198 84464 55183 2177 55215 PMC8650627__F8 Prediction of the Molecular Mechanisms Underlying Erlong Zuoci Treatment of Age-Related Hearing Loss via Network Pharmacology-Based Analyses Combined with Experimental Validation 4988 1268 2550 2912 351 1431 5733 2913 1815 1269 1814 6752 1813 2099 3569 6772 2064 5468 7124 5781 5091 3725 7422 5743 3558 4314 4843 1956 207 6714 3320 3606 PMC8651602__F2 Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis 11113 5831 29920 5625 65263 54790 2539 3091 PMC8653577__F2 Maturing heart muscle cells: Mechanisms and transcriptomic insights 6722 2475 2066 3091 PMC8656934__F2 Targeting Metabolism to Control Immune Responses in Cancer and Improve Checkpoint Blockade Immunotherapy 2475 7248 3099 3939 940 355 4609 941 324 948 50943 PMC8658259__F4 Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area 2691 6774 467 3479 7249 7248 1950 2475 PMC8658460__F10 Crosstalk between E-Cadherin/Beta-Catenin and NFKB Signaling Pathways: The Regulation of Host-Pathogen Interaction during Leptospirosis 999 1499 4316 PMC8660802__F2 Biogenesis and release of exosomes 3135 3383 928 967 975 7251 PMC8662121__F1 Type I interferon in the treatment of COVID‐19 59272 57506 7099 4615 29110 7098 3661 3665 51284 51311 PMC8662335__F7 REC8 enhances stemness and promotes metastasis of colorectal cancer through BTK/Akt/Beta-catenin signaling pathway 9985 695 1499 PMC8663935__F2 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions 10533 23192 64422 55626 9776 8408 60673 55062 83734 9140 9474 55054 7405 PMC8663935__F4 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions 7248 6009 5728 7942 7030 5163 8408 PMC8663982__F5 Cytokine signaling inhibition on inflammation-driven tissue remodeling 4092 4091 4089 4087 4088 655 2475 10454 PMC8664842__F8 Working model of KDM6B inhibition in neuroblastoma 595 1021 1019 1869 10664 23135 4613 1029 2146 PMC8666006__F7 MLH1−/−-mediated cGAS activation and immunotherapy 5888 9156 115004 PMC8666372__F1 Activated and inactivated canonical Wnt signaling 4040 4041 324 999 PMC8666431__F7 Precise Identification of Recurrent Somatic Mutations in Oral Cancer Through Whole-Exome Sequencing Using Multiple Mutation Calling Pipelines 2260 5290 3482 2033 108 3709 3708 1956 2263 238 5331 23236 5578 5582 2261 6098 PMC8667725__F4 Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities 59272 7018 7450 7099 11093 4018 5340 PMC8669501__F1 SNAIL1: Linking Tumor Metastasis to Immune Evasion 6469 51684 324 1499 10763 4087 4088 4089 2475 PMC8670931__F5 Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound 3306 7088 9261 2139 2118 2018 4778 6382 1009 4155 PMC8674037__F6 Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice 51094 9817 8452 4094 9978 PMC8675329__F3 Novel Insight Into the Fate of Cardiomyocytes in Ischemia-Reperfusion Injury: From Iron Metabolism to Ferroptosis 378 8031 23657 6520 8678 9817 79094 83939 7054 468 PMC8677621__F8 Possible mechanism by which MCPIP1 regulates the EMT process and the Beta-catenin level 6424 83999 80319 1452 84133 1499 6935 6591 6615 PMC8678610__F5 Lactic Acid Transport Mediated by Aquaporin-9: Implications on the Pathophysiology of Preeclampsia 338340 100379198 25874 51660 366 PMC8683177__F1 Tumor-Specificity Growth Factor Combined with Tumor Markers in Nuclear Medicine Imaging to Identify Prostate Cancer Osteonosus 4049 7189 4615 8195 2885 2002 6850 5163 867 914 581 572 637 PMC8684172__F2 Regulated cell death: discovery, features and implications for neurodegenerative diseases 114548 22861 58484 9447 79792 PMC8685420__F3 Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer 7422 7057 7045 285 5329 5155 596 1029 2353 3725 5328 4790 4193 1026 2064 3684 3685 PMC8687399__F6 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy 407020 324 51701 4040 4041 1499 PMC8687399__F8 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy 407020 324 4041 22943 51701 596 PMC8688647__F1 Network map of Elabela signaling pathway in physiological and pathological conditions 4088 114548 834 3606 1277 59 1536 653361 4688 84335 595 5290 207 2475 6198 8320 9573 10468 7040 6862 PMC8688647__F3 Network map of Elabela signaling pathway in physiological and pathological conditions 545 3014 1111 187 3569 3383 7124 7040 6347 26762 836 142 9474 10533 9140 643246 5594 5595 1978 207 2475 6198 PMC8688647__F4 Network map of Elabela signaling pathway in physiological and pathological conditions 2353 551 1392 187 7124 3569 3553 581 596 207 2475 PMC8688805__F2 Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review 6775 3458 10140 894 960 4553 920 2475 54541 1956 6774 652995 100124700 102659353 PMC8689584__F2 The major DNA damage repair pathways impaired in HPV-positive cancers 675 545 7515 7157 5925 9320 595 5888 165918 PMC8692119__F1 Novel contributors to B cell activation during inflammatory CNS demyelination; An oNGOing process 5970 7186 5971 29851 930 613 2475 2932 PMC8692700__F2 Functional role of Pescadillo ribosomal biogenesis factor 1 in cancer 8313 1499 23481 6925 5728 23476 3091 2932 PMC8693183__F5 Gill Transcriptomic Responses to Toxin-producing Alga Prymnesium parvum in Rainbow Trout 3929 2002 10454 7186 9261 6722 2 1401 3717 6774 PMC8694526__F2 Recent Advances in Osteoclast Biological Behavior 2885 50966 6009 7249 7248 4286 54209 6850 7006 100124696 695 29760 126014 PMC8698417__F1 Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation 9817 8452 2932 9978 PMC8698417__F4 Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation 4094 9817 4199 PMC8699551__F3 Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger 65018 9927 4077 9532 7917 717 10133 8887 9531 8408 23410 596 9530 4485 29110 9529 PMC8699595__F2 Abscission Checkpoint: A Guardian of Chromosomal Stability 128866 472 55165 3619 92421 PMC8700067__F2 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease 107966124 100187761 2475 8408 3312 9140 PMC8700067__F4 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease 8408 2475 9140 7942 PMC8700074__F1 Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases 196 405 1543 57491 1316 5966 PMC8700172__F1 Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives 7124 7291 406903 999 3480 652 3491 1490 4856 8840 8839 8838 1950 10397 4312 1000 1499 PMC8701796__F6 Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia–Reperfusion 5582 2784 5566 22941 2773 59345 2913 2782 7220 9456 50944 2787 2771 2752 PMC8702080__F1 Genetic Insights into the Impact of Complement in Alzheimer’s Disease 721 1378 1431 727 718 717 729 730 2271 735 7448 966 PMC8702962__F1 Osteosarcoma and Metastasis 9242 6352 860 2194 3397 PMC8705541__F2 Thyroid Hormone Nuclear Receptor TRA1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer 1499 6925 324 PMC8705881__F1 MicroRNAs Regulate Cell Cycle and Cell Death Pathways in Glioblastoma 8660 2885 2475 1956 5728 6774 4255 4193 1317 4318 1021 1019 PMC8706409__F10 Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage 5894 3717 6774 2626 2002 7124 3551 PMC8706757__F2 Necroptosis in disease and treatment 23118 257397 717 7188 7186 8717 1540 8772 355 8737 197259 11035 7098 7099 PMC8708687__F2 Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers 4609 7019 367 2475 3172 7004 10131 10000 PMC8710012__F1 Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis 4485 9113 26524 60485 4609 22943 374 2625 7042 595 PMC8710012__F4 Hippo signaling pathway in leukemia: function, interaction, and carcinogenesis 4485 9113 26524 60485 718 1025 PMC8714953__F1 Porcine Reproductive and Respiratory Syndrome Virus Evades Antiviral Innate Immunity via MicroRNAs Regulation 57506 3661 3656 7189 7098 51284 51135 66008 4615 3665 3455 7297 6773 10379 9021 PMC8715940__F5 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes 558 572 23385 4311 5170 5663 1141 2915 1524 2904 3725 4217 2475 3643 8851 6774 5743 836 2932 4915 23621 5290 PMC8715940__F6 Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes 7124 8851 572 4843 817 1131 1513 2081 4217 4842 823 1457 5743 5293 5663 1514 5290 836 2932 1075 2904 329 2475 5664 3551 3725 9451 1147 5170 PMC8716518__F11 Extracellular vesicles (EVs) isolated from key time points after burn injury induce differential gene expressions, predicted to significantly impact immune functions in macrophages in vitro 9760 84273 6102 PMC8717053__F1 Antiviral effect of antineoplastic agents inhibiting mTOR/PI3K signaling pathway in SARS-CoV-2 infection in cancer patients 2475 59272 5728 PMC8717598__F1 Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway 3652 355 2242 PMC8720622__F7 LncRNA LINC00460: Function and mechanism in human cancer 2146 901 728192 22992 1499 PMC8721856__F2 Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors 8314 467 23657 23476 6520 55611 9817 83939 468 PMC8724284__F4 Wnt/Beta-catenin signalling: function, biological mechanisms, and therapeutic opportunities 2932 1499 324 23043 1401 4920 4919 PMC8724616__F1 IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity 3479 3480 5163 PMC8724844__F7a Cellular RhoA Functions by the Integrated Application of Gene Set Enrichment Analysis 100170220 8773 6810 2054 6809 6843 6844 9341 8673 10282 8674 8676 9342 8675 10228 55014 6811 10652 10791 53407 55850 6845 8417 9482 PMC8725472__F8 SCUBE3 downregulation modulates hepatocellular carcinoma by inhibiting CCNE1 via TGFB/PI3K/AKT/GSK3B pathway 222663 7046 898 1017 PMC8727779__F3 Strategies to overcome drug resistance using SHP2 inhibitors 3717 2549 1950 1445 6714 2885 PMC8727908__F2 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling 5970 23476 6615 6935 4092 4318 3569 PMC8727908__F8 Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling 4318 999 3569 2335 50507 PMC8730355__F1 Contribution of the cardiomyocyte to tissue inflammation in cardiomyopathies 729230 2919 115004 PMC8732357__F2 DDRugging glioblastoma: understanding and targeting the DNA damage response to improve future therapies 6741 545 472 2191 142 7515 4255 55215 2178 PMC8739177__F4 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF 4318 1588 5159 2064 3791 367 31 2099 196 3486 7157 1576 4313 3569 2100 7124 6462 1543 5054 PMC8744084__F2 Molecular regulation of brain metabolism underlying circadian epilepsy 10135 23411 406 1407 9575 8864 1408 1628 3131 7008 2475 4783 6096 6095 7248 7249 PMC8750478__F9 Adipose-Specific PPARA Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue 23178 5465 355 19 9619 949 6646 PMC8750485__F1 Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases 8564 8942 10135 4837 23098 PMC8750774__F2 Metabolic Implications of Immune Checkpoint Proteins in Cancer 942 941 940 29851 2242 PMC8756109__F7 Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11 619501 3916 83547 1956 PMC8758217__F1 Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients 83939 468 22926 8452 9817 9978 467 PMC8758994__F1 De novo lipogenesis 3418 23152 3417 55902 355 47 PMC8760698__F5 Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension 4088 2475 83939 5159 596 5053 114548 3146 PMC8761767__F1 Interleukin-33/ Suppression of Tumorigenicity 2 in Renal Fibrosis: Emerging Roles in Prognosis and Treatment 59307 6347 90865 4615 51135 4088 7189 59 1386 PMC8763503__F8 STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway 7421 6778 10533 PMC8764032__F4 Proximity ligation strategy for the genomic reconstruction of microbial communities associated with the ectoparasite Caligus rogercresseyi 1738 1629 3712 56922 549 3155 35 27034 26275 3033 3028 PMC8770286__F2 Crosstalk Among YAP, LncRNA, and Tumor-Associated Macrophages in Tumorigenesis Development 102723099 554203 283422 6477 6478 4485 9113 26524 735301 100316868 60674 110599565 PMC8771160__F8 Pyridinium-type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of Beta-catenin 2932 324 6925 595 4609 3725 PMC8772744__F4 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease 2932 9817 847 PMC8772992__F3 Preventive Effects of Beta-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases—A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD) 5950 57016 9227 8694 84649 9249 10901 124 157506 5959 125 126 51109 216 8854 220 1592 56603 1381 1382 5915 6257 PMC8773597__F2 Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders 637 581 114548 596 847 2475 9817 PMC8773742__F1 Recombinant Proteins-Based Strategies in Bone Tissue Engineering 4090 4086 7474 81029 650 659 652 89780 860 100187761 51176 324 121340 1499 4827 PMC8774282__F2 Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished 2475 3845 23440 2261 238 5979 PMC8775994__F3 Photic Entrainment of the Circadian System 150094 5187 2353 3725 8864 PMC8777499__F1 Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer 6470 5723 29968 4522 26227 10797 441024 6472 PMC8780935__F3 Research progress on the hedgehog signalling pathway in regulating bone formation and homeostasis 655 650 652 468 3549 6469 6608 64399 51684 2688 860 2932 1499 7471 PMC8785327__F4 Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain 54413 9369 2741 5121 11337 10243 816 140679 2554 2560 2556 2562 6529 2572 6521 6507 26227 29968 6472 PMC8786487__F3 Pharmacological Effects and Underlying Mechanisms of Licorice-Derived Flavonoids 7099 4615 9817 3725 3553 PMC8786676__F6 Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation 4170 6403 8407 960 406995 PMC8795407__F1 The Hippo pathway signalling cascade and its stimuli 60485 92597 55233 4485 9113 26524 4771 10494 7003 8463 7004 7005 9686 652 857 PMC8797698__F1 Immunotherapy and radiation for high-grade glioma: a narrative review 196 920 405 3620 3586 50943 29110 3661 3665 PMC8799033__F3 Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer 11316 6678 1282 1301 6696 1277 1293 1303 PMC8799118__F5 Discovered differentially expressed lncRNA AC010973.2 can act as a diagnostic and prognostic biomarker for colon adenocarcinoma 387569 1630 1950 7039 2078 374 7046 836 2885 4087 4088 4089 572 324 1499 6010 2475 581 595 51426 PMC8799861__F5 CGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy 115004 3661 79792 26524 9113 4485 3383 7018 PMC8799861__F6 CGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy 115004 5140 7099 7098 3661 PMC8800364__F5 Immunometabolism in biofilm infection: lessons from cancer 7422 942 958 4843 PMC8807479__F4 Functions and Regulation of Translation Elongation Factors 285381 1801 1802 2242 92715 89978 51611 1938 PMC8810793__F8 Overall schematic diagram 983 891 54882 10413 378938 3014 10111 4361 472 PMC8819670__F1 Hippo pathway consists of distinct oncogenic and tumour suppressive modules 60485 55233 9113 26524 7003 8463 7004 7005 4485 4771 4018 29888 10494 387 183 PMC8820467__F2 Canonical Wnt/Beta-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering 4090 4086 22943 1499 4040 4041 324 3549 2146 84444 860 864 6608 PMC8822594__F3 New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer 6774 154860 3691 3918 4026 595 4170 728192 10365 2146 100130776 100188857 4615 8451 PMC8825370__F3 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer 8772 7186 1998 8717 572 637 581 150365 PMC8825714__F5 UHPLC‐QTOF/MS‐based comparative metabolomics in pectoralis major of fast‐ and slow‐growing chickens at market ages 56261 51573 162466 1103 43 PMC8830542__F1 Nevi, dysplastic nevi, and melanoma: Molecular and immune mechanisms involving the progression 673 5728 5443 4157 PMC8831078__F2 Ubiquitination of AMPA receptor subunits 9101 64854 324 999 26001 7321 7334 4193 PMC8831132__F1 NAD+ in COVID-19 and viral infections 130013 142 95 952 203447 10135 23098 PMC8832002__F7 S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3B/Beta-Catenin Signaling 4041 4040 2932 324 1499 6925 6275 999 1277 1000 PMC8832734__F2 Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview 55000 5820 283120 100507246 100885775 4904 100652772 641638 5976 PMC8832753__F2 B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages 6850 29760 695 5336 8915 10892 930 572 5728 5266 2932 7187 7186 5971 PMC8832957__F2 Tumorigenic bacteria in colorectal cancer: mechanisms and treatments 759 7097 7099 84890 4513 4149 8454 165918 5888 PMC8833084__F5 Combined Proteomic and Metabolomic Strategy for Allergens Characterization in Natural and Fermented Brassica napus Bee Pollen 2689 2203 8789 PMC8834116__F7 Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway 7431 59 999 2335 1277 PMC8834120__F3 Landscape of PDK1 in Breast Cancer 6009 572 7249 4193 23678 1958 PMC8834130__F1 Oral Immune-Related Adverse Events Caused by Immune Checkpoint Inhibitors: Salivary Gland Dysfunction and Mucosal Diseases 941 942 2638 29851 940 613 958 5091 920 PMC8835853__F1 Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis 7249 7248 51256 5163 6009 5728 8131 10641 9681 64223 1977 PMC8835994__F2 MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration 596 54700 2972 5879 466 2353 4609 3725 2002 6774 PMC8836041__F2 Autophagy by the Glycogen Synthase Kinase-3 (GSK-3) Signaling Pathway 7942 10763 2932 PMC8836259__F10 Oncogenic Mutation BRAF V600E Changes Phenotypic Behavior of THLE-2 Liver Cells through Alteration of Gene Expression 3434 435 9636 684 91543 2919 115361 5698 3965 90865 6352 6373 8743 3627 9966 3553 3606 4314 170692 4318 4319 PMC8840228__F3 Muscle stem cell adaptations to cellular and environmental stress 1977 7248 7249 PMC8841479__F4 Narrative review for the Hippo-YAP pathway in cancer survival and immunity: the Yin-Yang dynamics 9113 26524 4193 5894 PMC8841529__F6 Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks 55183 165918 149840 112441434 54537 80169 79991 100134934 PMC8842882__F1 Signaling networks orchestrate metabolism for coordination of T cell fate 4609 10538 920 3662 PMC8843871__F3 Paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine 8451 110599565 1499 1975 388685 5820 5520 100124700 10419 4839 302 PMC8843872__F1 Ferroptosis: An emerging therapeutic opportunity for cancer 8031 2182 10162 23657 6520 2879 PMC8846289__F1 Immune Reconstitution Following Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: A Review on Behalf of the EBMT Autoimmune Diseases Working Party 100507436 920 4397 3458 PMC8848474__F1 Antitumor activity of the dual PI3K/mTOR inhibitor gedatolisib and the involvement of ABCB1 in gedatolisib resistance in canine tumor cells 5728 7249 5163 2309 PMC8850363__F1 Immune and Metabolic Alterations in Liver Fibrosis: A Disruption of Oxygen Homeostasis? 4280 348 3091 6387 9575 10869 PMC8855927__F1 Itaconate, Arginine, and Gamma-Aminobutyric Acid: A Host Metabolite Triad Protective Against Mycobacterial Infection 7124 3659 4163 114548 7099 PMC8858079__F1 IGF cascade 3480 3482 3667 2885 596 5163 2475 595 PMC8859437__F3 Aldosterone-Regulated Sodium Transport and Blood Pressure 1956 6714 6770 7536 PMC8864926__F1 Metabolic engineering of Escherichia coli for efficient biosynthesis of butyl acetate 3045 100187828 466 PMC8866688__F1 Hypoglycemia Impairs the Heat Shock Protein Response: A Risk for Heat Shock in Cattle? 3315 8550 3337 7327 10963 10273 PMC8868324__F7 Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling Pathway 2695 27035 2879 PMC8868544__F1 AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis 5053 196 9817 405 PMC8868556__F5 Melatonin as a Smart Protector of Pregnancy in Dairy Cows 27113 3976 27085 4193 581 PMC8869508__F3 Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches 58484 114548 3553 57506 79671 4513 PMC8869699__F3 TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target 7097 8651 54472 11314 79671 1540 467 929 114609 4118 4615 7189 10333 7096 4261 PMC8869775__F1 Assays Used for Discovering Small Molecule Inhibitors of YAP Activity in Cancers 60485 4485 92597 55233 9113 26524 PMC8869954__F1 RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart 5894 4609 4851 6714 3716 6774 1432 2932 156 PMC8870287__F2 Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity 3480 3479 2475 572 PMC8872331__F4 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma 999 8434 4314 4318 7078 406937 6868 PMC8872619__F3 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells 387066 983 94009 618 2305 1956 283120 PMC8872619__F5 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells 5728 4824 618 572 1017 26220 2078 7018 5328 595 596 6935 5327 387590 283120 PMC8872751__F6 Transcriptome analysis reveals transforming growth factorB1 prevents extracellular matrix degradation and cell adhesion during the follicular-luteal transition in cows 7040 9076 999 90952 1950 6382 1277 PMC8874522__F2 Cerebellar and Striatal Implications in Autism Spectrum Disorders: From Clinical Observations to Animal Models 4478 1813 1812 2821 PMC8874739__F6 PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism 23013 154 2902 2149 2260 613 952 114 5351 5335 51196 89869 8877 57620 5266 3270 845 489 10345 6261 444 3708 7416 805 7134 85366 5530 818 4842 5153 3707 PMC8875223__F1 Cellular Metabolism during Candida-Host Interactions 355 2023 5340 114548 50943 4609 2597 PMC8876702__F2 Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies 92737 2475 387 3516 100188776 9780 PMC8881374__F2 10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation 79170 8976 90427 84440 29916 1621 998 10019 7015 1019 1029 8631 3212 50855 90417 10951 5330 1588 54361 7490 1021 4609 3219 6926 595 11182 6836 79365 9440 6256 7157 6790 6837 8028 8082 6835 60678 3218 2033 53335 85409 23493 51187 22893 11094 11093 3214 6130 3213 3216 29989 6727 29889 440275 642968 79888 9719 3217 6206 28 6217 6143 340024 348932 169436 11224 6142 6132 11245 100131244 387640 PMC8883485__F2 FoxO transcription factors regulate mitochondrial biogenesis 7019 4899 23411 1727 2395 7389 3162 5166 PMC8883537__F5 Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma 3717 3718 8161 6774 5788 10019 8651 6777 7038 PMC8884377__F1 Endothelial-Mesenchymal Transition or Functional Tissue Regeneration – Two Outcomes of Heart Remodeling 7045 7939 1003 7450 1000 6774 59272 1636 PMC8888345__F2 Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition 1956 7249 7248 6009 2475 4609 3169 780 6714 23097 2444 6792 PMC8888452__F1 Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies 2475 324 1499 4089 4087 9794 3516 2033 7124 PMC8888544__F5 Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice 3263 213 23476 5008 629 51561 837 1326 6772 4790 3240 4792 10062 5004 196 3569 1437 5970 7099 3553 3726 718 1029 5468 2885 1839 3684 1956 1435 867 3725 PMC8888700__F2 Polycomb recruitment and action on target genes 8726 5931 5928 84733 9055 3720 22893 PMC8889000__F3 Autophagy: a multifaceted player in the fate of sperm 2697 79925 90410 10533 23411 128637 81876 9463 3815 6009 5879 57120 339345 PMC8890943__F13 Potential mechanism of MET alleviating COPD and CSE-induced GC resistance through activating Nrf2/HO-1 signaling pathway, which can promote the function and expression of MRP1 to increase the expression of HDAC2 260431 9817 8168 2642 2638 3066 PMC8891342__F3 Impact of intracellular innate immune receptors on immunometabolism 79671 2475 940 197358 7189 3458 7124 9447 10399 2308 50943 PMC8891382__F2 Tumor Immune Microenvironment and Immunotherapy in Brain Metastasis From Non-Small Cell Lung Cancer 4318 4313 6376 3082 5728 6366 1950 3553 2475 941 942 7124 PMC8891531__F1 Trained Immunity: An Overview and the Impact on COVID-19 7124 3553 9235 7097 7099 2475 64127 11016 PMC8894020__F5 Quantitative Proteomics Analysis Expands the Roles of Lysine Beta-Hydroxybutyrylation Pathway in Response to Environmental Beta-Hydroxybutyrate 7750 3516 7001 2098 23022 1315 4841 7528 1121 7037 8411 23788 6648 7414 2317 25820 824 5781 3054 475 2194 7416 57542 3339 9789 7311 6159 4015 1292 9984 9877 57405 1975 5903 4116 25929 23367 22948 6230 10808 87178 10963 4436 PMC8897452__F6 Colorectal liver metastasis: molecular mechanism and interventional therapy 4851 4440 8650 4854 4853 960 4088 4855 PMC8899159__F5 Sex‐related differential susceptibility to ponatinib cardiotoxicity and differential modulation of the Notch1 signalling pathway in a murine model 4792 5468 6256 3667 2100 4843 3458 3725 3091 2308 4280 7157 4609 7040 4088 6722 6667 1499 PMC8899988__F8 Novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway 6667 81930 7003 10376 PMC8904924__F1 Updated Review on Ozone Therapy in Pain Medicine 847 1728 9817 3558 3574 3569 3565 3586 3596 PMC8905719__F2 RAS pathway regulation in melanoma 4763 6655 6654 5781 2885 2475 4193 4286 2353 4609 PMC8905719__F5 RAS pathway regulation in melanoma 5781 6654 2885 PMC8908406__F1 Dawn of precision medicine in diffuse-type gastric cancer 130749 387 4087 4088 4089 2932 2263 10818 2885 2475 3082 PMC8908968__F2 Genetics and Epigenetics of Parathyroid Carcinoma 27123 2146 3090 7490 4040 4041 8313 1499 324 79577 PMC8909868__F2 Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma 23410 4193 4313 9817 581 4851 999 1000 PMC8910032__F3 Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis 3014 472 1021 1019 581 PMC8910759__F4 Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders 929 4615 7097 7099 51135 3654 7189 3656 6761 3554 90865 3556 6850 PMC8911031__F1 Coenzyme A Restriction as a Factor Underlying Pre-Eclampsia with Polycystic Ovary Syndrome as a Risk Factor 171546 2194 9388 8526 57104 4023 29956 91012 9791 81490 57088 56848 5320 79888 130367 95 PMC8913720__F1 Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease 3717 729230 6347 6608 2735 6354 4087 4090 6355 6360 2932 324 1499 PMC8913720__F2 Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease 3553 729230 6360 6347 619501 6354 8205 PMC8913936__F3 Proteomic Analysis Reveals a Novel Therapeutic Strategy Using Fludarabine for Steroid-Resistant Asthma Exacerbation 821 567 6892 6891 6890 7297 3716 3437 6772 6773 3717 7124 4397 PMC8914279__F1 Association of Viral Infection With the Development and Pathogenesis of Systemic Lupus Erythematosus 7494 60468 613 2146 10873 PMC8914608__F2 Emerging Biomarkers Beyond Leukotrienes for the Management of Nonsteroidal Anti-inflammatory Drug (NSAID)-Exacerbated Respiratory Disease 57628 90865 64806 85480 3565 3596 958 3569 PMC8915915__F2 Centrality of Myeloid-Lineage Phagocytes in Particle-Triggered Inflammation and Autoimmunity 7099 4615 7189 3553 8717 7186 PMC8921549__F7 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury 8772 355 5925 9817 581 PMC8922476__F3 Gut-brain axis of CCM disease 7099 10365 9314 11235 PMC8925223__F1 DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis 6309 1717 1718 3156 PMC8926078__F1 Non-Coding RNAs in Autophagy During Carcinogenesis 7248 7249 9706 8408 60673 9776 5728 3146 664 55626 22863 10533 64422 1956 7405 9140 9474 83734 55014 PMC8926145__F4 Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function 6608 51684 2736 650 860 78990 PMC8927079__F1 Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin 196 405 7018 1956 1543 1545 57491 PMC8927079__F2 Aryl Hydrocarbon Receptor in the Pathogenesis of Environmentally-Induced Squamous Cell Carcinomas of the Skin 5053 196 1545 1543 405 2052 PMC8929449__F9 Smoking-induced changes in buccal mucosal gene expression 6608 5664 650 7078 1452 9252 1401 8767 3075 8517 2115 3643 6789 10217 50944 9229 4915 23035 6198 3738 2042 9020 84271 898 9149 2962 2353 6788 405 6778 PMC8931059__F2 CD95-dependent apoptotic signaling 8772 836 637 PMC8932066__F4 Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments 107966124 942 928 967 3732 975 PMC8941137__F10 Beta-cell fitness comparison in Beta-cell replenishment under stress 5209 4171 3091 PMC8942302__F3 STAT3 pathway in cancers: Past, present, and future 8651 8835 9021 55384 1956 1950 6714 6774 5008 7099 54106 4513 100124700 PMC8942669__F3 Histone Methylation and Oxidative Stress in Cardiovascular Diseases 6839 6649 50507 5927 2146 6667 9817 10628 5080 4513 PMC8943305__F8 Clinical and Apoptotic Factors Defining and Predicting Steroid Resistance in Nephrotic Syndrome in Children 3240 581 596 PMC8945028__F2 Manipulation of Meiotic Recombination to Hasten Crop Improvement 23626 11144 5888 4436 80198 PMC8945338__F3 Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway 4485 60485 4771 5008 55233 92597 10413 2309 4976 4599 1499 PMC8945730__F4 Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age 6102 8408 9776 9140 83734 9474 10533 64422 PMC8946661__F8a Systematic Review to Define the Multi-Faceted Role of Lysine Methyltransferase SETD7 in Cancer 1500 860 8313 8549 6737 80854 595 404281 905 890 PMC8946764__F2 Unravelling the Role of Kinases That Underpin Androgen Signalling in Prostate Cancer 3099 83440 5208 10645 595 5062 80347 983 1021 1019 8536 367 1119 1024 1869 1025 6733 1956 6416 27347 5606 5608 6774 2064 28996 5607 55450 154043 65268 3570 65125 PMC8949405__F1 MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer 2475 3485 54541 3667 5290 5163 7249 6794 92335 5581 253260 6009 3091 64121 673 1975 6194 1977 PMC8950345__F2 Fanconi Anemia Pathway in Colorectal Cancer: A Novel Opportunity for Diagnosis, Prognosis and Therapy 57697 2177 2956 4436 4292 5395 5888 5889 PMC8951629__F2 Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin 7189 57506 7706 4827 4615 3661 7187 29110 3665 PMC8953969__GA STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS) 115004 114548 9447 29110 51428 81030 8737 11035 836 79792 197259 3454 PMC8954173__F1 Genetic Landscape of Peripheral T-Cell Lymphoma 3718 3716 3717 7297 6774 940 7535 920 3932 7409 6010 3702 1499 27040 2885 PMC8961363__F3 Floral Scents and Fruit Aromas: Functions, Compositions, Biosynthesis, and Regulation 735 95 729 PMC8962104__F2 Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications 6093 4653 358 468 7873 54499 10133 7494 627 PMC8965007__F6 Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation 324 1499 4086 PMC8965842__F4 MiR-223 as a Regulator and Therapeutic Target in Liver Diseases 114548 2920 348 6774 51534 5316 3949 3627 PMC8968138__F1 NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance 2885 2549 5163 7249 7248 4803 572 PMC8969450__F2 Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease prognosis? 7099 3553 4615 54106 6774 3717 6850 5336 718 7189 7097 7113 51135 51284 59272 PMC8976706__F4 Decellularized extracellular matrix mediates tissue construction and regeneration 60485 4485 26524 9113 PMC8977320__F1 Edifying the Focal Factors Influencing Mesenchymal Stem Cells by the Microenvironment of Intervertebral Disc Degeneration in Low Back Pain 359 9242 4843 3479 392255 655 344022 8200 2737 2735 2719 9311 55515 40 627 41 4803 PMC8978518__F9 Therapeutic potential of the human endogenous retroviral envelope protein HEMO: a pan‐cancer analysis 4151 1499 7018 324 8313 4040 4041 PMC8979689__F6 Folecitin Isolated from Hypericum oblongifolium Exerts Neuroprotection against Lipopolysaccharide-Induced Neuronal Synapse and Memory Dysfunction via p-AKT/Nrf-2/HO-1 Signalling Pathway 581 23621 6855 PMC8980082__F2 LncRNAs participate in the regulation of the apoptotic pathways in NSCLC 641638 7503 100124700 8717 103021165 103689844 331 85028 400619 84848 101154753 100507316 8772 637 572 55384 581 100506696 596 PMC8980269__F1 PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy 25800 3872 648 5906 55388 57447 2878 216 6386 2475 6657 8826 84944 5987 347252 6348 10049 PMC8980946__F1 JAK‐STAT core cancer pathway: An integrative cancer interactome analysis 2885 6772 9846 1270 3976 5008 1950 5728 5163 2475 7157 675 672 9055 80312 6773 6774 3082 9611 54880 6775 6776 6777 85480 6778 355 1021 PMC8984190__F2 Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer 6714 5311 998 9052 64083 5310 PMC8987494__F3 PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? 2475 1977 6009 5163 5728 PMC8988011__F7 Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions 4485 9113 26524 60485 27063 PMC8990433__F1 Cholesterol metabolism and its implication in glioblastoma therapy 355 3949 3156 10858 51441 1956 6714 19 PMC8990811__F1 Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation 324 941 942 23308 965 958 214 5817 3683 3689 933 914 940 1493 29851 920 5133 923 10666 201633 5788 6693 7054 3123 3106 PMC8992566__F4 Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms 5596 6790 7157 5925 6657 79923 4088 6714 5728 2146 367 9480 958 6774 4050 1499 PMC8992594__F2 Emerging actionable targets to treat therapy-resistant colorectal cancers 1956 673 1950 2064 2065 842 3082 7039 5728 2932 572 1969 PMC8992594__F4 Emerging actionable targets to treat therapy-resistant colorectal cancers 7422 3620 5970 3902 1493 PMC8996963__F2 Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue 5471 4323 355 79400 4313 948 4023 7018 7450 PMC8997587__F11 Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders 5725 5315 627 PMC8998814__F5 Metastasis and MAPK Pathways 466 1386 22926 7157 2296 2260 5515 6659 9580 PMC9000741__F2 Extracellular HSPs: The Potential Target for Human Disease Therapy 7099 3600 929 PMC9010499__F2 Intratumoral cancer immunotherapy exploiting anti-viral immunity 115004 29110 3661 3665 4615 54106 7098 51284 PMC9010822__F4 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances 7991 2627 84314 26123 64399 54585 54985 3845 6469 6608 6794 57758 8643 5727 60485 55733 51684 84976 PMC9010822__F6 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances 2475 596 5159 9429 79923 6657 960 2735 6608 26123 6469 2810 PMC9014242__F8 Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4 3716 8660 6778 3718 5310 399687 PMC9014248__F3 USP13: Multiple Functions and Target Inhibition 11073 1017 8975 4967 545 472 672 47 6449 22863 8266 7917 7415 PMC9018988__F1 Molecular Network of Colorectal Cancer and Current Therapeutic Options 3845 324 4089 673 4255 1029 4292 4397 PMC9019414__F4 Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer 5595 1950 7422 847 3569 5447 3725 338340 5743 31 5327 581 2099 3156 43 23531 3553 6401 5328 196 1509 7157 5468 7124 572 1956 PMC9019486__F3 miR-874: An Important Regulator in Human Diseases 1024 6387 3148 324 1499 7021 360 358 283120 6774 100506211 9113 26524 10413 4485 51684 2735 6608 5727 PMC9019694__F2 Apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review) 105373113 103021165 1000 2146 26524 5912 1019 6662 2064 3949 5829 100124700 693198 9734 100302211 286411 6774 8091 8609 5728 10365 894 400643 1956 5218 4087 890 9775 643911 PMC9019694__F5 Apoptosis, autophagy and ferroptosis by non-coding RNAs in metastatic non-small cell lung cancer (Review) 7134 100124700 1856 2309 128338 25836 3014 11065 261726 10919 3068 2475 8491 64422 PMC9020058__F7 De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet 775 2786 9568 5522 2810 1280 23236 51305 6300 6696 9133 3381 5747 995 1852 5347 7060 3673 991 3685 9232 6714 3859 54474 8202 6657 2719 89780 1499 1496 7015 332 PMC9020237__F1 Emerging role of the itaconate-mediated rescue of cellular metabolic stress 56670 3553 467 PMC9020878__F12 Huangqin Tang Interference With Colitis Associated Colorectal Cancer Through Regulation of Epithelial Mesenchymal Transition and Cell Cycle 999 1499 1019 595 PMC9021242__F1 Hippo signaling pathway 4485 60485 26524 9113 9686 4609 PMC9021355__F2 Pathological features of tissues and cell populations during cancer cachexia 5034 3479 3667 26227 2308 2309 2152 2475 3569 3976 4087 4088 PMC9022973__F2 Gal-8 on cytokine expression and secretion 2475 960 7124 9902 3553 PMC9024590__F3 Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells 472 4193 7503 3065 581 PMC9024672__F2 Oxidative Stress and Ischemia/Reperfusion Injury in Kidney Transplantation: Focus on Ferroptosis, Mitophagy and New Antioxidants 9817 140809 1728 7296 2730 5226 2944 2539 2495 30061 2879 PMC9025063__F5 Genome Integrity and Neurological Disease 7508 5887 3978 7507 5426 7515 PMC9027317__F10 Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway 7099 4615 9817 355 5465 PMC9028333__F1 Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities 468 57761 572 2475 3397 6657 PMC9028356__F1 Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer 23456 2235 1371 5498 10058 54977 9429 210 7389 3145 7390 PMC9028856__F1 Autophagy Process in Cervical Carcinogenesis: Role of Non-Coding-RNAs, Molecular Mechanisms, and Therapeutic Targets 8878 55210 10533 64422 9140 2475 6199 6009 253260 9474 8678 8408 PMC9029738__F2 Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network 2475 1977 7249 7248 4318 4131 2932 23237 PMC9032679__F2 Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer 246751 55669 9927 4976 4977 581 PMC9037237__F4 Supplementation of Specific Collagen Peptides Following High-Load Resistance Exercise Upregulates Gene Expression in Pathways Involved in Skeletal Muscle Signal Transduction 5447 1440 7099 930 2885 5747 5728 3265 11140 6794 5515 4515 7249 5578 4846 6009 2309 572 1147 64223 598 596 7157 5106 92579 4609 27 4170 1537 PMC9038119__F1 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species 10724 8473 367 2821 2597 2539 7360 2632 7086 PMC9038420__F2 Effects of Nrf2 in Exercise Intervention of Neurotoxicity Caused by Methamphetamine Oxidative Stress 8452 9978 9817 PMC9039220__F3 Challenges and Opportunities Associated With Platelets in Pancreatic Cancer 387 999 1000 4851 4318 596 595 100653366 PMC9039735__F3 Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns 10135 203447 142 143 10038 952 64802 349565 23057 93100 PMC9042615__F7 Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway 59352 6648 3603 PMC9046588__F3 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy 4615 7189 3276 23210 PMC9047021__F2 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer 10533 7099 4615 8408 5921 PMC9047021__F3 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer 29843 55054 9474 PMC9047021__F4 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer 6009 2475 6648 54487 84844 2648 PMC9052234__F2 Cytokines in Abdominal Aortic Aneurysm: Master Regulators With Clinical Application 7852 5154 3553 90865 729230 3579 3627 7048 7046 3570 1234 3596 PMC9052535__F1 Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells 6464 2885 4087 4088 10454 4089 4086 4090 6608 51684 11060 6662 860 4040 4041 1280 176 1499 6660 55553 324 3516 100188776 PMC9053805__F4 In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps 4487 2273 3479 9353 653 6750 7432 6387 10370 5764 6363 7124 939 608 4692 2162 64388 7857 2841 6774 27299 6418 3845 PMC9060113__F1 Targeting the PI3K/Akt signaling pathway in pancreatic B‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes 5728 5163 2932 572 23035 23239 PMC9063252__F8 Effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy 22848 3066 59272 PMC9063567__F1 Altered Cholesterol Homeostasis in Huntington’s Disease 9023 1718 10858 1717 1593 PMC9065266__F1 Inflammasomes in Cancer Progression and Anti-Tumor Immunity 4615 3661 114548 4671 22861 3930 58484 55655 199713 171389 338321 91662 9447 79792 3553 100187761 PMC9065266__F3 Inflammasomes in Cancer Progression and Anti-Tumor Immunity 114548 355 171389 58484 9447 3458 8205 79792 6935 56169 7124 PMC9066101__F1 Smad3 Signatures in Renal Inflammation and Fibrosis 1025 1499 23411 4089 1401 4088 4087 4092 PMC9066101__F3 Smad3 Signatures in Renal Inflammation and Fibrosis 1401 4089 4087 4088 1017 1019 PMC9068506__F3 Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response 59272 57506 51311 51284 4615 10379 6773 PMC9076740__F2 Maturation of beta cells: lessons from in vivo and in vitro models 5315 5091 4191 2475 2805 2806 4190 8402 8604 4199 6576 47 2819 2820 3417 3418 PMC9093150__F10 Working hypothesis of the role of the prostanoid pathway in angiogenesis inhibitor-induced hypertension and renal injury 100187907 80312 4512 PMC9095530__F6 Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation 23788 637 581 355 8772 836 8717 8737 331 PMC9096207__F2 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination 10631 6774 8205 6367 920 PMC9099129__F3 Natural killer cells in liver transplantation: Can we harness the power of the immune checkpoint to promote tolerance? 7535 920 3932 PMC9099669__F2 Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective 6622 55737 120892 7345 65018 8867 23400 27429 PMC9101426__F2 Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer 4087 4089 4609 5290 2475 2064 3845 3082 2549 3716 6774 PMC9102468__F1 LINC00665: An Emerging Biomarker for Cancer Diagnostics and Therapeutics 4040 4041 1956 324 11338 6667 1499 51701 57016 57650 4087 PMC9103474__F2 Oral Microbiota-Driven Cell Migration in Carcinogenesis and Metastasis 6935 1950 2932 9839 999 6774 182 100507056 2621 4837 1499 10562 5728 28984 51701 PMC9103477__F1 Comprehensive Investigation of Steroidogenic Signaling in Classical and New Experimental Cell Models of Adrenocortical Carcinoma 367 6770 1586 4158 1589 2798 PMC9108237__F11 MicroRNA-382 Promotes M2-Like Macrophage via the SIRPA/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis 140885 6774 383 PMC9108399__F2 Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRA) in Cancers 2674 6714 2475 6615 9314 9048 PMC9109208__F5 It's about time; divergent circadian clocks in livers of mice and naked mole-rats 5187 9572 9975 8864 1408 6518 1407 8863 1628 2645 406 9575 3795 PMC9112923__F5 Identification of Alzheimer’s Disease Molecular Subtypes Based on Parallel Large-Scale Sequencing 7018 100124700 400931 4609 100507246 652995 1950 1026 1432 5563 1956 2885 5894 23411 5599 PMC9114485__F2 Pathways Linking Nicotinamide Adenine Dinucleotide Phosphate Production to Endoplasmic Reticulum Protein Oxidation and Stress 4199 3418 160428 6472 10797 6470 4522 10840 PMC9114649__F2 Influence of Arginine Methylation in Immunity and Inflammation 3276 4261 4792 3122 7054 324 PMC9114649__F3 Influence of Arginine Methylation in Immunity and Inflammation 3553 7124 10419 7185 4792 3627 6364 6373 PMC9114649__F4 Influence of Arginine Methylation in Immunity and Inflammation 3276 10498 6352 3627 3665 3434 6890 10419 84166 50943 54496 PMC9116921__F2 Ongoing Clinical Trials in Aging-Related Tissue Fibrosis and New Findings Related to AhR Pathways 196 7046 4087 4088 4089 2932 1499 23411 23410 PMC9116923__F3 Autophagy and Renal Fibrosis 7124 7249 7248 2475 51083 8408 9140 8678 9706 665 23710 664 596 10533 PMC9120667__F1 Metabolism and Endocrine Disorders: What Wnt Wrong? 22943 79971 324 1499 4040 4041 3276 64840 PMC9121494__F2 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer 64094 387 1499 9575 406 2932 1408 8864 2475 8914 142 4862 1453 PMC9123149__F2 Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock 952 5167 84890 100 PMC9128097__F1 Rhythm disturbance in osteoarthritis 11096 4322 4323 6662 8864 9572 5187 1628 3553 4087 4086 406 9575 10135 23411 2006 3371 1280 176 1407 1408 9975 PMC9130463__F3 Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases 7442 4089 920 2625 PMC9130478__F3 Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases 4615 3654 51135 1540 23118 257397 7124 6347 3383 7189 29102 7403 23135 4609 2002 2113 27161 1956 PMC9132726__F3 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium 355 6608 57037 23432 158763 5144 PMC9134593__F2 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases 23118 257397 10454 8767 7187 57506 197358 3665 3596 22861 3661 171389 114548 91662 199713 58484 4671 338322 79792 3603 PMC9138536__F2 Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence 7099 1520 3627 7535 2638 7124 1230 3586 5008 113277 11214 10333 284021 2885 115650 1794 29760 2921 10507 5588 399694 644150 2920 302 1017 3075 1282 92241 PMC9138619__F2a Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids 4050 1432 4803 29760 4049 4067 4055 7186 64127 695 7292 8915 8740 1896 5970 602 5966 650 100187761 2833 3659 2920 3627 6373 3579 6347 1325 729230 1232 6364 5008 6401 1437 7424 2324 2057 5328 3977 5340 3976 7054 344901 831 355 PMC9139060__F2 Low-Grade Inflammation in the Pathogenesis of Osteoarthritis: Cellular and Molecular Mechanisms and Strategies for Future Therapeutic Intervention 114548 834 4615 7189 3146 2313 PMC9139349__F2 Alterations of Mitochondrial Network by Cigarette Smoking and E-Cigarette Vaping 7019 4899 7018 55669 9927 4976 51024 PMC9139536__F3 Novel T Follicular Helper-like T-Cell Lymphoma Therapies: From Preclinical Evaluation to Clinical Reality 324 3932 6850 941 942 3702 55620 7409 27040 5335 2885 387 29851 940 PMC9141422__F1 Ganglioside GM3 Synthase Deficiency in Mouse Models and Human Patients 7368 7357 9334 8869 8705 6483 6762 81849 PMC9141761__F1 Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update 2002 3667 2932 5163 2475 PMC9144890__F5 CD44 Mediates Oral Squamous Cell Carcinoma-Promoting Activity of MRE11 via AKT Signaling 4361 960 4151 PMC9147806__F3 Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2 29110 3661 57506 7187 7706 3454 7297 3716 6772 6773 10379 PMC9152203__F3 Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment 12 2267 3263 5950 4133 5604 350 3858 710 629 PMC9157790__F4 Wnt Signaling in the Breast: From Development to Disease 1499 999 4041 22943 4040 8324 6422 27121 8323 340419 59352 343637 8549 6423 11197 6425 27122 PMC9160188__F3 Nonapoptotic Programmed Cell Death — Ferroptosis, Necroptosis, and Pyroptosis — in Pancreatic Ductal Adenocarcinoma Treatment 114548 79792 4485 PMC9160826__F1 Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma 2879 121549 10162 4015 8031 3162 PMC9160826__F2 Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma 27198 2182 2879 4495 1728 2495 3658 9817 55847 1356 2553 8031 7538 25824 PMC9164251__F1 Exploiting Extracellular Vesicles Strategies to Modulate Cell Death and Inflammation in COVID-19 59272 3454 3455 10379 6773 4193 3665 PMC9166417__F1 PIKfyve as a drug target 200576 9896 5266 90809 5728 PMC9168169__F2 Advances in the study of RNA-binding proteins in diabetic complications 9474 5140 114548 3553 3651 9927 3638 3481 2475 3727 1654 3190 PMC9169370__F2 Pyroptosis in inflammatory diseases and cancer 22861 114548 58484 9447 79792 1687 7124 8737 8772 839 81030 11035 841 55876 56169 3001 3002 PMC9170767__F1 FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks 10400 220 218 217 10390 23761 3931 10162 3176 100137049 4128 3067 1644 10908 10434 138199 55748 3034 84735 131669 144193 10841 56261 123745 26279 255189 5321 64600 5322 8399 84647 8605 PMC9177993__F1 Chromosomal synapsis defects can trigger oocyte apoptosis without elevating numbers of persistent DNA breaks above wild-type levels 84072 23626 150280 5591 545 472 PMC9178153__F2 Autophagy in muscle regeneration: potential therapies for myopathies 7942 5081 23411 9474 8408 65018 100187761 4656 PMC9178660__F3 Advances in Immunosuppressive Agents Based on Signal Pathway 2475 1956 5164 6009 5728 8821 5163 3480 3667 1950 7249 7248 PMC9179380__F2 NOTCH1, GATA3, and c-MYC in T Cell Non-Hodgkin Lymphomas 2322 3815 920 5897 5896 960 717 355 718 727 50943 729 PMC9179421__F1 Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells 3099 5209 2744 7006 100124696 355 1374 1003 PMC9187046__F1 GSK-3 regulates PD-1 and LAG3 expression for enhanced T-cell reactivity 920 940 3932 1499 941 942 3902 PMC9188347__F1 Metabolites as drivers and targets in rheumatoid arthritis 3099 2539 3939 730249 PMC9189173__F7 Study on plasma amino acids and piperonamide as potential diagnostic biomarkers of non-small cell lung cancer 6472 29968 8639 4129 PMC9189345__F1 Research progress of endothelial‐mesenchymal transition in diabetic kidney disease 4088 4087 4089 324 1499 PMC9190019__F6 Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation 64285 5936 7039 1499 1956 999 PMC9191825__F4 Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19 629 3845 1675 1431 730 735 7097 7099 3656 7189 23118 3586 3661 57506 338376 22861 114548 6773 6774 59272 3559 7850 PMC9192598__F2 Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter 6789 10397 3428 4494 1958 6662 2919 629 1690 330 3569 3725 51776 11214 7035 4312 5054 3486 19 4318 3673 5328 51129 2633 7058 9590 6280 4628 PMC9192945__F1 Myeloid Cells in GBM Immunosuppression 116071 945 929 967 942 6347 10875 4282 3579 3576 2919 4318 6774 941 3417 3418 PMC9194098__F2 Traditional Chinese Medicine in Bone Regeneration and Osteoporosis 1499 10371 8829 2932 650 PMC9200548__F1 Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy 387 2475 596 664 55384 2885 PMC9201453__F2 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases 6667 7045 4087 4088 1733 5292 1017 4314 619501 PMC9204147__F4 Daily Intake of a Phaseolus vulgaris L. Snack Bar Attenuates Hypertriglyceridemia and Improves Lipid Metabolism-Associated Plasma Proteins in Mexican Women: A Randomized Clinical Trial 2688 651 2152 10194 2255 4023 8788 51129 3383 7412 8764 948 729230 7124 4322 4318 4312 958 64806 56034 PMC9204280__F10 FOXP4-AS1 May be a Potential Prognostic Biomarker in Human Cancers: A Meta−Analysis and Bioinformatics Analysis 8624 91433 5983 5984 84154 51645 10799 8607 6502 5471 6631 6732 6749 5422 79723 54962 5198 84306 10606 10131 9319 10360 4869 9656 54069 136647 4528 101060264 23160 29028 471 4176 55299 705 51690 790 8872 79080 57819 993 10128 8318 51053 51659 9837 2618 2091 55215 9521 79075 1736 51692 201161 55839 PMC9204297__F3 NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression 1431 627 114548 948 7097 7099 79792 59341 PMC9208265__F2 Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy 3001 3002 2879 4025 948 23657 6520 55876 79792 1687 114548 6772 PMC9209730__F3 New Sights Into Long Non-Coding RNA LINC01133 in Cancer 100505633 4087 9242 93986 9518 PMC9209741__F3 Medulloblastoma and the DNA Damage Response 5728 5163 572 545 472 4193 PMC9213320__F1 Scaffold-dependent function of RIPK1 in experimental non-alcoholic steatohepatitis 8717 7186 8737 23118 257397 1540 81858 8772 836 11035 197259 PMC9213747__F2 Malignant Myeloid Leukemia by Mesenchymal Stem Cells 9242 4513 23237 7040 5228 3553 4282 972 3611 7412 2621 558 1499 284 3579 2919 PMC9213771__F7 Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling 9741 9375 7355 55858 64083 7357 53947 9334 29956 81537 8879 196 8613 8877 PMC9214065__F1 Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell 4040 4041 1499 324 2932 9118 PMC9218731__F1 Cardiomyocyte death in sepsis: Mechanisms and regulation 7099 24145 79792 8737 11035 197259 90550 114548 1612 2879 23411 PMC9220138__F4 Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls 1376 6576 47 7019 2194 4771 948 PMC9221189__F1 O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway 4018 4485 60485 26524 9113 PMC9223478__F7 Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish (Siniperca chuatsi) 4553 83939 468 PMC9225571__F1 Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis 4485 355 60485 374 PMC9230675__F6 Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells 672 675 5888 472 142 7515 PMC9230742__F6 Combined Transcriptomic and Proteomic Profiling to Unravel Osimertinib, CARP-1 Functional Mimetic (CFM 4.17) Formulation and Telmisartan Combo Treatment in NSCLC Tumor Xenografts 175 581 5008 6774 6657 4312 1956 PMC9231089__F15 Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis 1950 1956 6714 6774 283871 PMC9231138__F11 Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U−2 OS Cells through CD44 and Chemokine Signaling 3576 2308 960 999 3569 6774 PMC9234285__F3 Biological Characteristics of HLA-G and Its Role in Solid Organ Transplantation 3135 2833 729230 920 PMC9235300__F2 Telocytes in Fibrosis Diseases: From Current Findings to Future Clinical Perspectives 2475 84870 3082 7046 8549 324 4087 4088 1499 4089 64781 581 29965 860 PMC9237101__F7 Model depicts the role of the IDO1-MDM2-p53 pathway in DLBCL growth 3620 4193 581 PMC9237930__F1 New dawn for cancer cell death: Emerging role of lipid metabolism 406961 442909 948 22937 19 3949 38 239 3156 406959 2194 857 6093 8878 1374 1956 10533 54947 PMC9238060__F1 Epigenetic modifications in drug resistance and treatment of breast cancer 4087 4089 4088 1956 324 1499 PMC9238361__F2 Sirtuin Family and Diabetic Kidney Disease 23410 23409 23408 8140 120103 160728 9390 93100 65220 22933 84561 23411 51548 51547 PMC9240200__F2 Vicious Cycle: In Severe and Critically Ill COVID-19 Patients 59272 1636 7099 6774 PMC9240433__F8 Breast Meat Fatty Acid Profiling and Proteomic Analysis of Beijing-You Chicken During the Laying Period 335 7941 836 55825 291 2542 948 338 11332 285848 337 2170 1374 2180 253017 5534 5257 3030 33 1376 11057 2171 7533 225 8877 3033 10449 488 1632 7125 301 38 7134 55862 PMC9242402__F4 Metabolic Regulation of Hematopoietic Stem Cells 586 2744 2805 2806 PMC9243315__F2 Paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine 2064 57646 6655 2069 5784 7422 4884 100188864 864 100422909 8626 5091 2638 694 581 2262 1956 1499 PMC9247709__F9 Schematic diagram illustrating how miR-21/PARP-1 activates the PI3K/AKT signaling pathway to induce EMT and migration of 16HBE cells 999 1000 6935 PMC9247951__F2 Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance 8828 2624 5629 3082 6714 11197 7849 1746 4092 6696 PMC9247951__F3 Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance 11249 5361 836 23344 6405 23129 8828 22858 56104 821 6622 2100 6935 7422 9723 7424 7869 10512 7048 56920 840 1956 10550 5594 51241 4204 10381 4897 8829 55558 6714 1385 2101 7311 5364 10752 3679 3688 7026 596 6774 1499 PMC9250200__F3 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis 3084 10718 652 2475 2668 2247 666 268 PMC9250975__F2 Ubiquitin Binding Protein 2-Like (UBAP2L): is it so NICE After All? 4087 999 1000 1499 6667 9898 891 5728 983 PMC9251307__F1 Molecular Mechanism of Caffeine in Preventing Bronchopulmonary Dysplasia in Premature Infants 22926 468 6647 9817 6648 PMC9254480__F1 VEGF/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment 7424 2277 7422 7423 8829 8828 572 2475 5894 2534 998 9261 PMC9256556__F1 TNF in the liver: targeting a central player in inflammation 581 7124 8737 8717 7186 7188 8772 11035 197259 PMC9258520__F1 Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications 130013 8564 8942 8140 120103 23410 23409 23408 92014 10135 349565 93100 64802 23057 65220 160728 6581 203447 22933 952 23098 4837 84561 51547 23411 51548 PMC9260904__F10 Genome-wide Meta-analysis Reveals New Gene Signatures and Potential Drug Targets of Hypertension 133 1956 1052 9575 7124 1906 PMC9261390__F1 Implications of Sphingolipids on Aging and Age-Related Diseases 1674 79603 253782 29956 91012 10715 204219 56848 8877 PMC9266916__F1 Neuroimmune Mechanisms Underlying Neuropathic Pain: The Potential Role of TNF-Alpha-Necroptosis Pathway 7186 8717 8737 11035 197259 8772 PMC9268799__F5 Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway 1020 8851 7015 3717 823 890 3932 5515 5770 6714 595 5599 25 3716 5602 5604 5578 5747 367 598 5159 PMC9271571__F1 NFKB Inducing Kinase Regulates Intestinal Immunity and Homeostasis 5966 5970 7186 7187 717 5971 PMC9273868__F5 Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform 1616 9934 5788 2908 3098 2539 9312 5609 3790 7186 151 5532 10273 6647 7415 PMC9274608__F3 Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers 283460 29946 8205 6416 PMC9277157__F8 Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-29a Improves Ovarian Function of Mice with Primary Ovarian Insufficiency by Targeting HMG-Box Transcription Factor/Wnt/Beta-Catenin Signaling 324 26959 1499 PMC9277309__F5 Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD 56950 5310 5311 2475 260402 4282 23411 PMC9277406__F1 Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs 1576 324 54658 PMC9277484__F4 Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland 51176 90780 3223 5077 4038 6909 6926 10718 2625 2737 7124 4487 4488 367 4040 8660 PMC9279633__F1 Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles 2475 8408 9706 9776 29982 22863 10533 64422 9140 9474 351 8301 55014 9342 11337 7405 7942 PMC9284064__F2 Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target 4615 2833 1956 PMC9284214__F2 Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections 115004 29110 3661 3665 85364 7189 55593 1445 114088 PMC9284893__F7 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface 27330 5156 5532 2252 1399 27092 5894 6197 57551 2317 5871 3551 5321 6655 4217 1848 2005 5604 5921 776 4893 2260 10000 784 2247 5566 1398 783 23542 9448 2353 2250 51701 7048 5159 5922 7042 777 5494 4296 6789 9693 5908 5530 7189 1846 7043 7157 4215 59283 7046 5536 80824 4214 6722 2254 2246 PMC9287179__F8 Mechanism of the ANKFN1 gene in HCC 387 5111 595 1021 1019 2885 PMC9287895__F3 Emerging strategies to overcome resistance to third-generation EGFR inhibitors 558 2885 1956 6774 6714 4609 5163 4914 5728 2475 238 5979 6098 PMC9297570__F5 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states 1956 2064 55364 PMC9298504__F1 Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease 7249 7248 6009 2696 9340 23400 2740 57521 8867 2475 64223 84335 6622 64798 120892 60673 9776 114548 8408 9706 9140 83734 55737 10533 9474 596 64422 55054 7405 65018 55626 9829 PMC9299441__F8 Neutrophil Survival Signaling During Francisella tularensis Infection 331 5209 7097 2932 581 5163 572 PMC9300166__F1 Mismatch repair and clinical response to immune checkpoint inhibitors in endometrial cancer 4436 2956 5395 5426 5424 4292 PMC9301867__F5 Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation 1956 3576 4313 7422 5925 1029 1356 2776 10014 3265 5295 25942 595 7157 5290 207 10320 1026 2064 2308 4916 2475 5604 3326 1027 3320 PMC9302576__F1 Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment 3466 6772 7099 3656 3566 6774 6778 PMC9302637__F2 Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy 627 3717 6774 2554 1960 2557 PMC9303584__F2 Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics 1021 1019 673 4193 4763 6772 6774 1956 1017 5728 572 PMC9304296__F4 DNA damage response proteins in canine cancer as potential research targets in comparative oncology 11073 9656 84126 545 PMC9304626__F1 Oxidative Stress and Lipid Peroxidation: Prospective Associations Between Ferroptosis and Delayed Wound Healing in Diabetic Ulcers 23657 2937 2879 PMC9307586__F12 MicroRNA expression profiling of endocrine sensitive and resistant breast cancer cell lines 9073 5010 11031 7058 4015 4017 4193 60494 9218 10580 1293 1290 50848 2200 1292 10000 998 858 208 329 1280 894 1281 1301 1282 1289 8038 5799 1286 50509 1284 23362 481 5087 2625 6645 3479 3915 2932 23179 5155 3688 6934 5294 5602 5728 7422 5156 288 5295 7328 54894 PMC9310348__F1 Apoptosis regulation through protein–protein interactions 355 8772 637 317 90427 8739 638 572 666 581 PMC9310369__F1 Main mechanisms of mitochondrial DAMP signalling 7019 581 578 115004 26284 57506 340061 29110 5970 3661 3665 24145 5971 54106 177 912 3456 7124 3553 5027 324 PMC9310501__F3 STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis 3953 3976 6774 5879 9021 6185 1050 407009 1499 54361 PMC9310501__F4 STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis 113218481 10401 3976 6774 100187907 126014 4318 PMC9310545__F1 Signaling pathways producing pro-inflammatory cytokines 6850 57506 3661 3665 7124 114548 9447 79792 834 PMC9311450__F1 Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches 3479 572 5163 637 581 PMC9312706__F2 Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics 2932 581 999 23657 PMC9312812__F1 Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer 201163 96459 57600 6009 7248 7249 PMC9312812__F5 Emerging Link between Tsc1 and FNIP Co-Chaperones of Hsp90 and Cancer 2475 201163 96459 9675 57600 64798 64223 6009 7248 7249 PMC9312989__F6 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies 5728 1956 5295 6794 2064 7248 5290 207 2475 7249 3845 3265 238 673 5604 6016 5979 4763 6098 PMC9314780__F3 Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations 5212 8074 9365 1499 100187761 3480 3479 PMC9315226__F2 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? 10746 4215 5607 5598 4205 100271849 4208 4209 4893 673 2353 PMC9315226__F3 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? 3845 1956 6714 673 3480 5159 2353 PMC9315629__F3 Circular RNA in Brain Tumor Development 3075 23036 4318 4784 10114 55833 143 92799 6659 146057 PMC9315842__F2 Ferroptosis defense pathways 2729 2879 2643 1719 1723 PMC9316611__F2 Indoor Secondary Pollutants Cannot Be Ignored: Third-Hand Smoke 1950 1956 3725 2353 4609 6188 596 PMC9317051__F3 Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia 6418 3717 613 2885 9846 3716 25 6774 1399 2475 6608 2146 1499 PMC9317121__F11 BMP Signaling Pathway in Dentin Development and Diseases 650 653 651 5083 860 4488 4487 1834 1758 PMC9320222__F9 Ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells 672 3364 5810 5884 545 472 675 5888 6117 4361 4683 10111 PMC9322447__F3 Fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2 574506 100302281 7939 4087 4088 7046 7048 4089 4313 PMC9322659__F8 Comparing Transcriptomes Reveals Key Metabolic Mechanisms in Superior Growth Performance Nile Tilapia (Oreochromis niloticus) 39 10682 120227 3422 1717 51144 1582 6718 10858 PMC9323628__F3 Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and Apoptosis 9097 10600 7874 10869 23326 7345 4609 55611 219333 9100 83844 367 8237 8314 10213 1956 2305 PMC9324774__F1 Therapeutic Potential of Carnosine as an Antidote against Drug-Induced Cardiotoxicity and Neurotoxicity: Focus on Nrf2 Pathway 9817 2932 8452 9978 PMC9326561__F4 Integrative Proteomic and Phosphoproteomic Analyses of Hypoxia-Treated Pulmonary Artery Smooth Muscle Cells 8682 1152 10409 808 2026 3099 2022 6510 51129 84572 79921 4199 1284 5091 2919 5954 6513 10398 5534 5096 7042 55856 7168 1303 1277 5537 7171 1278 151987 1281 26608 771 1290 5170 6678 51164 2590 4924 4087 2495 51260 708 79778 5738 3150 5763 25828 48 7037 537 710 54439 7388 6648 5660 6451 55168 54534 116540 7106 9168 10960 10282 2926 56945 10972 2079 4666 3181 284695 9647 5709 25839 23398 6136 81892 4904 1108 22938 11198 51663 57532 4076 55646 23185 392 55226 353 56474 94056 9416 9221 1736 1211 1212 30846 11267 11137 359948 PMC9329277__F4 Integrated genomic sequencing in myeloid blast crisis chronic myeloid leukemia (MBC-CML), identified potentially important findings in the context of leukemogenesis model 2146 171023 84295 2624 7157 1523 7490 10320 10594 5291 25 442263 5781 472 11200 675 PMC9332298__F2 PNPLA1-Mediated Acylceramide Biosynthesis and Autosomal Recessive Congenital Ichthyosis 64834 6785 2531 126410 204219 2180 285848 51099 84649 7038 PMC9334798__F1 Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends? 5447 10162 2182 29923 27165 1723 6520 2879 23657 467 7249 5728 4771 999 PMC9338646__F3 Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment 115004 3627 29110 6352 3661 3659 3458 6772 80312 10135 PMC9340488__F4 Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions 6868 59272 51311 51284 4615 5971 7113 51135 7098 3665 8717 10379 7099 3553 6774 3717 7297 6772 3569 6347 3627 4283 PMC9343696__F1 Crosstalk between the CBM complex/NFKB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment 126669 3845 1021 1019 6774 6478 1874 144455 PMC9344019__F2 Emerging roles of ER-resident selenoproteins in brain physiology and physiopathology 57190 140606 1734 3703 55829 51714 7415 58515 9403 51109 PMC9346324__F2 Retrospective analysis of endocrine disease in sphingosine-1-phosphate lyase insufficiency: case series and literature review 6611 5091 253782 29956 204219 10715 79603 91012 PMC9351103__F8 Astragalus mongholicus Bunge and Curcuma aromatica Salisb. inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8/CXCR2 axis and PI3K/AKT/mTOR signaling pathway 3576 2475 999 3553 3579 1000 PMC9353726__F8 Network of deregulated genes that were differentially expressed upon c-MYC inhibition after lomitapide treatment as determined by Ingenuity Pathway Analysis. Color code: green, downregulation; red, upregulation 332 1649 84875 572 4609 100131390 4792 599 4790 4793 94241 695 381 PMC9355528__F4 Targets and treatments affect oxidative stress in gliomas: An overview of molecular mechanisms 2475 6469 3549 472 PMC9357883__F3 Molecular mechanisms underlying the role of hypoxia-inducible factor-1 A in metabolic reprogramming in renal fibrosis 5728 2475 5163 3939 PMC9359975__F6 Extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells inhibit the tumor environment via the miR-125b/HIF1A signaling pathway 7291 9839 6935 PMC9362849__F1 Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation 90268 81858 3014 472 9825 8717 1540 PMC9362849__F5 Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation 9825 8717 8737 142678 1540 55364 7124 7186 83737 PMC9363567__F3 Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases 929 7097 961 PMC9364625__F3 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity 2645 1236 940 1237 1233 PMC9365986__F2 Immunoregulation effect of tumor microenvironment in pancreatic ductal adenocarcinoma 8205 100133941 960 182 1499 100653366 PMC9367255__F2 Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy 7189 9474 10533 64422 51284 PMC9367715__F1 NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells 9817 8452 9978 PMC9367715__F2 NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells 9817 8452 9978 79728 10072 PMC9376779__F1 Transcriptome changes in stages of non-alcoholic fatty liver disease 948 59272 89780 2252 10221 2354 7069 3479 114789 1316 6319 4199 3164 5313 51655 PMC9377080__F2 Diverse functions of FAT1 in cancer progression: good, bad, or ugly? 4040 4041 2195 10413 1839 9542 3084 1956 1950 2475 3667 PMC9379326__F2 Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets 51 355 1071 1581 3931 4023 PMC9380140__F7 Upregulation of RCAN1.4 by HIF1A alleviates OGD‐induced inflammatory response in astrocytes 3091 4513 3606 3569 PMC9386326__F8 Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFB signalling pathway 9991 7046 7358 9817 619501 PMC9387558__F1 Hormone supply to the pituitary gland: A comprehensive investigation of female-related tumors (Review) 999 2691 6750 3717 2690 3479 PMC9388335__F7 Inhibition of Kruppel-like factor 7 attenuates cell proliferation and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis through nuclear factor KB and mitogen-activated protein kinase signaling pathway 8609 4312 3553 PMC9388724__F5 Neuronal ferroptosis after intracerebral hemorrhage 2879 8237 10365 23657 581 PMC9393484__F1 Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling 1813 2775 10846 111 1812 2774 3208 PMC9394413__F2 Normal and Pathological NRF2 Signalling in the Central Nervous System 9817 8452 9978 PMC9396386__F6 Time-course transcriptome analyses of spleen in rainbow trout (Oncorhynchus mykiss) post-Flavobacterium psychrophilum infection 3929 23643 929 10750 100187907 4609 6955 4615 5132 4790 1147 4792 3593 3627 6373 PMC9399520__F7 Celastrol ameliorates osteoarthritis via regulating TLR2/NFKB signaling pathway 7097 114609 4615 4513 4322 PMC9400419__F1 Targeting the Hippo pathway in heart repair 60485 4485 9113 26524 PMC9403519__F9 Posaconazole inhibits the stemness of cancer stem-like cells by inducing autophagy and suppressing the Wnt/Beta-catenin/survivin signaling pathway in glioblastoma 1499 9474 960 79923 6657 PMC9405571__F3 Multifaceted Roles of Autophagy in Infectious, Obstructive, and Malignant Airway Diseases 114548 9140 51548 2475 5071 100420149 8678 7942 1080 260431 3146 PMC9406972__F2 Tumour Derived Extracellular Vesicles: Challenging Target to Blunt Tumour Immune Evasion 8205 324 1493 355 942 941 3458 3587 3588 PMC9409040__F7 Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer 1737 57107 1877 5536 1111 472 545 9894 PMC9409657__F6 Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis 355 8772 581 23411 PMC9410782__F1 Advances in Research on the Molecular Function and Specific Role of Circular RNA in Cardiovascular Diseases 4615 23411 3162 10000 4205 23237 4040 9444 65018 2308 PMC9410805__F7 Proanthocyanidins Activate Nrf2/ARE Signaling Pathway in Intestinal Epithelial Cells by Inhibiting the Ubiquitinated Degradation of Nrf2 9817 8452 9978 571 5091 4094 PMC9412785__F1 RAS signalling pathway and therapeutic approaches to target this pathway in cancer 6654 2885 6655 5728 6009 5163 7249 7248 7465 3611 1019 6790 PMC9414016__F1 Dual role of fucosidase in cancers and its clinical potential 2523 2524 2525 2526 2527 2528 2529 2530 10690 84750 170384 23509 23275 2762 2517 2519 PMC9414397__F4 Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities 4118 4615 51135 3654 3656 7189 23118 257397 7187 29110 3661 PMC9414803__F4 Portulaca oleracea L. Extract Regulates Hepatic Cholesterol Metabolism via the AMPK/MicroRNA-33/34a Pathway in Rats Fed a High-Cholesterol Diet 7038 64241 3931 19 5444 335 1581 PMC9420447__F7 Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages 929 7099 51135 3654 4615 7189 10454 23118 7187 29110 3663 3665 3661 PMC9420733__F2 Signaling pathways in obesity: mechanisms and therapeutic interventions 3667 4852 181 5443 4925 655 5858 3479 5728 7350 1734 PMC9420733__F6 Signaling pathways in obesity: mechanisms and therapeutic interventions 23237 5697 885 5443 4158 4852 181 4159 4160 PMC9421435__F4 Role and Therapeutic Potential of Macropinocytosis in Cancer 7168 6352 2919 3569 PMC9421970__F2 microRNA expression in acute myeloid leukaemia: New targets for therapy? 23405 3205 894 578 55294 1021 208 54790 355 7534 4170 2623 4211 144455 688 1869 2475 64919 27250 8835 23411 4294 5728 84254 999 3146 5594 2113 161742 5580 5163 4893 2308 2309 2152 5604 10217 54206 PMC9424640__F7 Therapeutic potential of NR4A1 in cancer: Focus on metabolism 4513 947 9242 3164 PMC9424811__F2 RING finger protein family in health and disease 7097 10333 115992 25897 4615 55298 55905 27246 7189 7099 54476 221687 7187 3661 55072 81790 7098 51284 54106 79589 10193 220441 PMC9425222__F3 DNA Repair Pathway Genes Associated With Ataxia 7515 3980 142 10038 11284 55775 54840 3978 2237 5982 5111 5981 5983 5984 10111 4361 472 672 675 5888 PMC9425815__F1 Involvement of host microRNAs in flavivirus-induced neuropathology: An update 442912 442917 693148 693173 724032 23118 257397 10454 4091 729230 4792 29110 3661 91404 PMC9425815__F3 Involvement of host microRNAs in flavivirus-induced neuropathology: An update 1915 57506 55922 7187 7128 51284 26994 6772 4851 54941 51499 6774 5609 9655 3659 5728 PMC9426616__F2 Human immune polymorphisms associated with the risk of cryptococcal disease 5894 6850 64170 10892 8915 7189 7097 10333 7096 51135 3654 4615 7099 3661 51311 54106 51284 7100 29110 81793 7098 7187 PMC9428607__F2 Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression? 1816 1812 1815 1813 1814 2931 2932 PMC9433872__F6 Research progress on RNA−binding proteins in breast cancer 1385 124540 4485 9113 693223 4609 8091 7408 PMC9433876__F1 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response 999 4485 26524 9113 4771 PMC9433876__F4 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response 4485 9113 7189 11078 571 PMC9436901__F8 Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway 64170 8915 9474 PMC9438157__F9 M6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway 54890 110806271 23381 54541 5976 2475 2669 PMC9441498__F6 Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma 5728 999 595 PMC9445132__F3 Mitophagy: A potential therapeutic target for insulin resistance 8878 6714 8408 65018 664 139341 7416 PMC9446437__F3 Systematic review of gastric cancer-associated genetic variants, gene-based meta-analysis, and gene-level functional analysis to identify candidate genes for drug development 7059 5728 7157 2475 1942 4582 1499 100188835 6714 1956 2885 3082 PMC9449579__F3 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy 1591 6713 2932 4193 8435 6646 2475 1499 1788 5728 PMC9450349__F5 ASXL1/2 mutations and myeloid malignancies 23476 8314 2475 PMC9450830__F4 Human arginase 1, a Jack of all trades? 445 3479 5163 PMC9454318__F5 Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway 2260 5663 1509 5295 3480 5591 6319 5423 2932 596 5290 1956 1075 7782 3791 22976 5241 6095 43 836 10858 1017 1277 5664 898 3398 3399 3400 3397 PMC9456329__F8 Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells 4094 9588 114548 834 3146 PMC9457836__F5 Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia 4615 3654 6761 90865 3567 3569 3596 PMC9459699__F7 Different Effects of Low Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Function and Insulin Secretion in Adolescent Male Rats 3667 2876 7124 6414 4036 3934 PMC9466978__F1 Decoding the Role of Familial Parkinson’s Disease-Related Genes in DNA Damage and Repair 6741 120892 672 65018 PMC9468507__F5 Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents 1401 2908 9447 PMC9468923__F1 Key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor 196 405 57491 1545 PMC9469021__F11 Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Carassius auratus Linnaeus) gill disease caused by Myxobolus ampullicapsulatus 596 581 823 8772 836 100506742 572 841 843 637 842 8797 1017 1021 1019 PMC9469619__F2 Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway 6608 374654 51684 2735 2737 2736 6469 5727 7424 4609 3549 50846 91653 50937 PMC9471064__F4 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets 8717 7186 8772 355 637 331 581 PMC9471952__F2 Neuregulin-1, a potential therapeutic target for cardiac repair 2065 2066 2932 1499 374 1956 3084 2064 4485 114548 PMC9475269__F3 Amino acid metabolism in skeletal cells 6662 2744 176 PMC9475360__F1 KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer 2475 3845 2885 6654 PMC9475360__F2 KRAS as a Key Oncogene in the Clinical Precision Diagnosis and Treatment of Pancreatic Cancer 3845 2885 2475 60485 9113 PMC9476644__F3 Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism 999 2932 1499 89780 4040 324 4609 581 PMC9476673__F3 Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis 3099 9619 19 1431 4967 8140 6510 PMC9476726__F3 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 2475 5728 1956 1950 5163 5164 572 PMC9479353__F5 Genetic regulation of RNA splicing in human pancreatic islets 150 26575 10287 7447 2740 111 26086 8622 2773 10480 6132 8663 3646 6142 6206 8664 6143 PMC9480600__F5 Exosomes in Pharyngucutaneous Fistula After Total Laryngectomy 114548 2729 23410 367 2475 9131 192111 9817 PMC9482139__F2 Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets 3099 3939 2539 PMC9482886__F2 AMPK regulation of the mTOR pathway and control of cell growth and autophagy 6009 7249 7248 64798 8408 64223 PMC9483763__F1 Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy 7248 7249 6009 5728 5163 9681 8131 10641 PMC9485555__F8 Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease 355 948 51 572 596 4282 972 PMC9495820__F8 Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells 2358 790 301 2744 PMC9496174__F1 Gut Microbiota Regulation of AHR Signaling in Liver Disease 196 6714 9049 405 57491 7808 PMC9496762__F2 Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis 4591 8805 54765 11074 2475 1956 10155 81559 6774 6657 81603 4102 4105 5970 10346 10206 1499 51592 2735 91107 80263 6737 22954 PMC9497187__F1 Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells 6610 6609 55512 55627 253782 29956 204219 10715 79603 91012 56848 8877 2531 8560 123099 2629 64781 7357 2720 9331 PMC9498168__F8 MiR-942-3p as a Potential Prognostic Marker of Gastric Cancer Associated with AR and MAPK/ERK Signaling Pathway 84515 1763 55055 84296 26586 64478 1996 59283 79075 253559 890 79801 1515 54715 2895 729993 63967 9863 2742 23025 29127 3925 2891 55789 6334 26047 4986 54443 9568 5602 5933 8618 3552 1030 144455 2353 7070 367 3817 1021 8013 6772 639 2296 79727 3852 10365 57510 8091 10637 10643 PMC9499665__F1 Could BMPs Therapy Be Improved if BMPs Were Used in Composition Acting during Bone Formation in Endochondral Ossification? 4089 3224 860 10454 121340 1749 PMC9501954__F2 P16INK4A—More Than a Senescence Marker 1021 1019 4193 1017 PMC9502658__F2 Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic 3661 3665 59272 7113 PMC9503046__F4a Antimicrobial Peptides and Biomarkers Induced by Ultraviolet Irradiation Have the Potential to Reduce Endodontic Inflammation and Facilitate Tissue Healing 7124 6885 6591 2335 1051 7189 4318 9020 7186 5604 1437 1950 1956 3458 5894 5578 7039 406921 1839 4319 2247 406984 4312 5879 2252 2263 PMC9503143__SF1 H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish 9817 6647 2950 6648 1728 PMC9503294__F2 Roles of Skin Langerhans Cells in Immune Tolerance and Cancer Immunity 6774 196 1830 50489 920 PMC9504455__F2 Crosstalk between Glycogen-Selective Autophagy, Autophagy and Apoptosis as a Road towards Modifier Gene Discovery and New Therapeutic Strategies for Glycogen Storage Diseases 2548 581 7248 7249 8408 7942 100124700 PMC9505042__F7 TGFB/SMAD Signaling Pathway Prevents Follicular Atresia by Upregulating MORC2 4087 4088 7046 7048 4089 22880 596 581 PMC9506158__F3 ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle 1975 7874 4193 7249 29110 3665 PMC9506445__F1 Association of Homologous Recombination–DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers 672 11200 580 5888 545 472 79728 2177 675 PMC9511411__F4 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy 7297 3716 6772 6773 3661 29110 PMC9511979__F1 Relationships among microbiota, gastric cancer, and immunotherapy 2932 1499 6469 PMC9511979__F2 Relationships among microbiota, gastric cancer, and immunotherapy 55236 2638 3458 3398 940 1493 324 PMC9513044__F2 Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment 6774 2932 324 1499 PMC9514046__F2 Interleukin 22 and its association with neurodegenerative disease activity 1235 3976 5132 1233 2826 2833 942 940 PMC9515494__F4 Systemic tryptophan homeostasis 3620 23475 23498 8942 8564 PMC9518657__F1 Control of aging by the renin–angiotensin system: a review of C. elegans, Drosophila, and mammals 183 1636 59272 PMC9519816__F2 Exploring the role of Nrf2 signaling in glioblastoma multiforme 9817 2932 4094 3725 1728 PMC9520027__F11 Identification of lysophosphatidic acid in serum as a factor that promotes epithelial apical junctional complex organization 4018 1902 57121 999 1499 6010 5819 PMC9520222__AF1 Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway 998 6662 1291 1277 1281 PMC9520222__F8 Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway 998 6662 1291 1277 1281 PMC9520263__F3 Tumor resistance to immune checkpoint blockade and combination strategies to overcome resistance 7097 7098 7099 51311 51284 6774 PMC9522619__F1 Properties of flavonoids in the treatment of bladder cancer (Review) 472 1017 993 545 983 995 5347 PMC9522619__F3 Properties of flavonoids in the treatment of bladder cancer (Review) 4087 4088 4089 4040 4041 2932 1499 595 6608 2735 2736 6469 5727 6774 6657 PMC9522619__F5 Properties of flavonoids in the treatment of bladder cancer (Review) 2475 6774 3213 6714 5347 4313 2495 468 PMC9523165__F1 Anticancer potential of cryptotanshinone on breast cancer treatment; A narrative review 3479 3480 3667 2308 5728 PMC9524263__F4 Melatonin pretreatment on exosomes: Heterogeneity, therapeutic effects, and usage 23411 3418 6774 PMC9524569__F2 Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway 3146 7099 4615 5970 114548 3717 6774 PMC9524788__F1 CGAS-STING Pathway - Implications for Systemic Lupus Erythematosus 6573 115004 983 29110 3661 PMC9525429__F1 Pattern to Link Adenosine Signaling, Circadian System, and Potential Final Common Pathway in the Pathogenesis of Major Depressive Disorder 406 9575 5187 1407 8864 PMC9526582__F2 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer 5218 140462 57214 54937 1618 1848 250 84842 9961 64648 8618 266740 3081 7431 249 23022 1244 114801 8082 1735 79875 22920 8988 8857 7033 3481 64699 3485 5196 968 5055 4922 7045 323 445582 2534 9369 8573 4638 4345 PMC9526582__F10 Identification of Novel miRNAs, Targeting Genes, Signaling Pathway, and the Small Molecule for Overcoming Oxaliplatin Resistance of Metastatic Colorectal Cancer 2615 5669 715 7422 8483 3566 5105 4067 948 2168 2316 8650 693221 780 PMC9526990__F1 Long non-coding RNAs affecting cell metabolism in cancer 3099 400500 2736 5163 3939 PMC9528626__F2 OxMIF: a druggable isoform of macrophage migration inhibitory factor in cancer and inflammatory diseases 4282 960 100187761 6714 972 3579 7852 4513 PMC9529885__F7 Diesel exhaust particles induce human umbilical vein endothelial cells apoptosis by accumulation of autophagosomes and caspase-8 activation 55014 10652 9342 8673 8417 PMC9533094__F1 Minimal residual disease in EGFR-mutant non-small-cell lung cancer 4485 9113 26524 4771 5163 2475 1956 PMC9539685__F1 Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development 29888 29966 6801 4609 983 1977 836 261726 842 PMC9539821__F2 Epigenetic factors in breast cancer therapy 27122 999 1499 2932 324 PMC9540681__F2 Human–rat integrated microRNAs profiling identified a new neonatal cerebral hypoxic–ischemic pathway melatonin‐sensitive 1950 4803 3479 126669 5728 2885 2475 1021 1019 581 PMC9543876__F5 Pathway analysis using GRB2, a significantly connected and downregulated protein as the focus 2444 7454 83737 6098 27040 5791 79705 64762 5747 9846 2885 6464 3815 25 868 25930 2064 5786 367 PMC9546849__F6 Other functions of WTAP in cancers 1956 4316 4582 79148 999 9589 604 762 2932 324 1499 7490 PMC9549509__F6 Therapeutic hypothermia alleviates myocardial ischaemia–reperfusion injury by inhibiting inflammation and fibrosis via the mediation of the SIRT3/NLRP3 signalling pathway 114548 140609 23410 6648 3553 PMC9549772__F2 Chinese Herbal Medicines for Diabetic Nephropathy Fibrosis Treatment 4853 1499 1121 999 PMC9550168__F6 SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway 3479 3480 6615 9839 PMC9556184__F1 Potential Role of Voltage-Dependent Anion Channel in the Treatment of Parkinson's Disease 7417 7419 65018 581 PMC9556450__F2 Drug transport across the blood-testis barrier 998 6194 207 208 2059 2153 PMC9560885__F2 Race to develop oral SERDs and other novel estrogen receptor inhibitors: recent clinical trial results and impact on treatment options 1956 595 1021 1019 2099 PMC9563021__F7 Baicalin Modulates Inflammatory Response of Macrophages Activated by LPS via Calcium-CHOP Pathway 5743 4843 6772 355 PMC9563266__F2 MARCKS in Metastasis and Treatment Resistance of Solid Tumors 4082 4318 387 2064 5728 6657 5243 PMC9563430__F5 PRELP Regulates Cell–Cell Adhesion and EMT and Inhibits Retinoblastoma Progression 892 51684 27148 6790 5591 472 63923 1855 5925 6714 2353 51701 6885 23118 5747 4149 7157 572 596 27113 637 581 8772 PMC9563553__F1 Impact of the Hippo Pathway and Cell Metabolism on Pathological Complete Response in Locally Advanced Her2+ Breast Cancer: The TRISKELE Multicenter Prospective Study 1499 3156 387 26524 9113 PMC9563963__F3 Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells 5820 100316868 643911 728655 101805488 283131 283120 642934 283460 378938 60674 100124700 652995 100750225 23642 100506696 55000 100885779 100132735 100506797 207 208 10000 100048912 100287616 100642175 84793 100505994 29931 154860 64002 102723932 84740 100129597 29034 554202 55384 441641 PMC9569554__F3 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair 2057 2056 860 8074 PMC9569554__F4 Hypoxia-Inducible Factors Signaling in Osteogenesis and Skeletal Repair 2050 2056 7249 2475 9242 PMC9569742__F1 Antiaging Activities of Phytochemicals in Dark-Colored Plant Foods: Involvement of the Autophagy- and Apoptosis-Associated Pathways 84971 64422 9776 60673 22863 7942 9140 9474 PMC9570087__F1 Protein Acetylation Going Viral: Implications in Antiviral Immunity and Viral Infection 5009 3428 10524 115004 9734 8841 23411 23252 3661 3665 10013 3454 3716 6772 10379 7297 6773 3455 9636 PMC9571513__F7 Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway 9817 2879 847 PMC9573519__F1 Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets 3553 3383 54106 2475 3611 2019 4318 PMC9574713__F7 Temporal Alterations of Sphingolipids in Optic Nerves After Indirect Traumatic Optic Neuropathy 427 410 2581 7368 7357 57704 PMC9576507__F3 Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19 59272 5447 114548 58484 9447 79792 22861 3603 PMC9576592__F7 Schematic model depicting the functions of SNHG5 during the proliferation and cancer stem cell-like properties of HCC 387066 6657 595 5976 1499 6925 619501 7471 80326 89780 79923 960 PMC9577001__F1 Cancer-associated mesothelial cells in the progression and therapy of ovarian cancer 5879 4087 4088 3082 999 1748 55600 960 4018 6366 5163 7474 2268 6374 2885 7410 PMC9577001__F2 Cancer-associated mesothelial cells in the progression and therapy of ovarian cancer 960 79923 6774 6347 7474 1234 100133941 PMC9579336__F1 Synthesis, function, and regulation of sterol and nonsterol isoprenoids 4553 6009 4047 3156 6713 54704 387 5912 57826 PMC9583871__F1 Anti-cancer immune responses to DNA damage response inhibitors: Molecular mechanisms and progress toward clinical translation 983 995 545 7465 993 1017 6772 7124 6778 3659 3665 3663 472 115004 29110 3661 3014 7189 7518 3981 920 PMC9585222__F7 Improvement of gut-vascular barrier by terlipressin reduces bacterial translocation and remote organ injuries in gut-derived sepsis 1003 2932 1499 PMC9585227__F1 Lipids for CD8+ TILs: Beneficial or harmful? 948 7124 3458 3002 5468 6774 1374 3902 3949 PMC9586738__F1 Correlation of Glucose Metabolism with Cancer and Intervention with Traditional Chinese Medicine 3845 2147 3098 5209 2821 3939 3945 226 229 2597 2475 PMC9588203__F1 Triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases 7535 6850 759 4513 PMC9588367__F2 Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis 1269 6790 7535 55215 1890 6097 5327 5428 2159 43 1559 1557 PMC9588904__F5 Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation 112609 351 55577 253012 7024 63892 7357 10628 4609 4149 3265 10797 54505 1869 79665 5728 7316 171483 5624 3481 7750 2335 2200 27231 51684 3684 2 5106 29126 7982 1286 5277 2033 79026 90070 10071 6769 472 2475 PMC9589207__F2 Non-cardiomyocytes in anticancer drug-induced cardiotoxicity: A systematic review 10533 2475 2066 2064 3084 PMC9594080__F1 Redox potential determines NSPCs fate 4015 57716 472 2475 9817 7157 PMC9597979__F7 Transcriptional regulation mechanism of wheat varieties with different nitrogen use efficiencies in response to nitrogen deficiency stress 108348016 1879 64641 7018 PMC9599207__F1 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 10413 60485 4485 9113 26524 PMC9599362__F3 NFKB Mutations in Germinal Center B-Cell Lymphomas: Relation to NFKB Function in Normal B Cells 613 2475 973 974 6850 84433 8915 10892 958 4615 54106 51135 3654 7189 PMC9599649__F2 Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology 940 1622 7410 998 5879 PMC9601273__F3 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer 11254 3717 6774 1950 1956 7422 9021 PMC9604078__F1 Rationale for Combining the BCL2 Inhibitor Venetoclax with the PI3K Inhibitor Bimiralisib in the Treatment of IDH2- and FLT3-Mutated Acute Myeloid Leukemia 3418 54790 5163 2475 648 1026 2322 5781 7157 4170 596 6774 4193 PMC9605425__F5 Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NFKB Pathway 7124 5970 7412 6347 3383 PMC9608318__F2 Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19 3454 3455 91543 3434 9636 PMC9613570__F2 Non-pharmacological interventions for vascular health and the role of the endothelium 1003 6714 9780 59341 10365 9314 PMC9616080__F3 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response 64750 9802 7189 9618 55540 PMC9616080__F4 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response 90865 9173 6761 4615 3654 7189 51135 PMC9616118__F9 Meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy 4615 6469 25805 6608 PMC96649__F4 Stimulation of iNOS production by Pln is dependent on the IFNG signaling pathway 3716 3717 6772 3659 4843 PMC9866016__F10 Alfalfa Xeno-miR168b Target CPT1A to Regulate Milk Fat Synthesis in Bovine Mammary Epithelial Cells 1376 33 37 34 1374 1051 948 PMC9913267__F3 Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis 4512 5228 5225 22949 145482 PMC9925018__F8 KDM4D and Hippo signaling pathway in the regulation of cell cycle activities 10413 4609 2638 9212 55693 1869 2305 PMC9935518__F7 Decision-making workflow for selecting treatment for newly diagnosed ER+/HER2- metastatic breast cancer patients 2475 2309 5163 165 1021 1019 PMC99889__F13 Erk activation following TCR stimulation 27040 7535 2885 PMC9999652__F8 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 64236 5211 8205 283587 PMC10030845__F1 Inflammasome and pyroptosis in autoimmune liver diseases 7099 4615 22861 114548 171389 58484 79792 PMC10035050__F6 Sodium acetate regulates milk fat synthesis through the activation of GPR41/GPR43 signaling pathway 31 2194 8694 PMC10035973__F6 RNA-seq and microRNA association analysis to explore the pathogenic mechanism of DHAV-1 infection with DEHs 7187 9927 23786 4857 PMC10037406__F5 Posttranslational modification in the cGAS-STING pathway 5537 284076 9654 10475 59343 91445 9830 115004 22954 23650 10206 79102 81844 6048 79594 267 27246 29110 3661 PMC10038327__F3 Mitochondria as disease-relevant organelles in rheumatoid arthritis 159963 7124 3606 3553 PMC10040407__F8 Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure 2182 7054 2879 PMC10041518__F1 Biosynthetic pathways for pyrimidine and purine nucleotides, relevant inhibitors and oncogenic regulators 545 1633 790 1723 2618 4860 978 7372 472 1719 83549 7371 1635 7084 8833 3615 3614 100 158 PMC107042__F1 Diagram showing the relationships among the regulatory factors governing srf transcription initiation 1311 266710 6722 10301 PMC1124928__F4 Coagulation, fibrinolysis, and angiogenesis in cancer 7018 7035 5340 2161 5196 PMC1160519__F6 Cardiac glycosides inhibit TNFA/NFKB signaling by blocking recruitment of TRADD to the TNFR 7124 8717 8772 7186 PMC1175050__F1 NFKB pathway regulates inflammation, dendritic cell (DC) development and function, and thymic selection and regulatory T cell production 958 4615 7189 5971 3725 2353 7124 PMC1199368__F5 Candidate genes that are involved with the metabolism of androgen and estrogen 3972 412 1583 6342 3283 7366 367 6462 3292 2100 2950 1312 PMC1216340__F10 Schematic model depicting potential mechanism that might contribute to epithelial-specific regulation of the CFTR gene 6722 1080 7528 10682 PMC1237076__F7 Wnt-NLK pathway inhibits the activity of Myb family of proteins by two different mechanisms 7471 10454 28996 51701 PMC125566__F1a Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 474168 324 1499 PMC1287678__F9 Putative signaling pathway of the evolutionarily conserved Toll/NFKB pathway utilizing the E 3929 54472 51135 51295 7189 PMC1288263__F2 Mammalian sex determination: a molecular view 6662 7490 6736 7536 PMC1351245__F1 Delayed Dark Adaptation in 11-cis-Retinol Dehydrogenase-deficient Mice 51109 5959 6120 PMC1371031__F4 Model on Bcr effects on Beta-catenin 1499 613 2932 4609 PMC139433__F2 Cell cycle arrest by transforming growth factor (TGF)B and their deregulation in cancer 4087 4089 993 1017 595 1019 PMC1397816__F5 Inhibition of Wnt signalling by a Fz-dependent pathway 4040 4041 51701 PMC140507__F1 The PI 3-kinase pathway by RNAi 5728 207 5163 208 PMC1413813__F8 The signaling pathway regulating the expressions of SMAlpha-actin, SM-MHC, and calponin in SMCs on polymerized collagen in response to PDGF-BB/IL-1B costimulation 5159 3554 2475 6722 822 PMC1440398__F2 CDC maturation upon virus infection 8772 57506 3661 PMC1458968__F4 Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin 1000 1499 7008 PMC1501017__F2 Different pathways involved in apoptosis 637 8772 581 836 790 842 317 PMC1502426__F1 Chromophore regeneration in vertebrate and invertebrate photoreceptors 6120 6121 9227 PMC151138__F1 Signaling and transcriptional pathways of Th1 differentiation and the potential role of c-Rel 324 3595 6775 6772 PMC1526596__F1 P38 mitogen-activated protein kinase (MAPK) signaling cascade in T cells 940 4616 1647 7535 PMC154144__F2 Canonic Wnt signaling pathway molecules can induce a similar phenotype 7480 1499 324 PMC1551980__F1 Ubiquitin Signaling in the NFKB Pathway 7186 7188 5966 5971 PMC1553197__F8 Model of CISK-mediated inhibition of CXCR4 sorting and degradation 5266 6387 7852 5163 PMC1557712__F2 Molecular control of alveolar morphogenesis 5241 8835 8651 2001 1983 3481 54361 7018 51286 1499 2066 7040 PMC1557825__F4 Ordering and correlation network diagrams for the significant pathways 5734 5731 5742 23236 6915 5732 6916 5737 5743 9536 5321 5740 2052 5739 1573 2053 5733 50814 223 216 217 57016 1592 501 1591 8854 224 219 1594 PMC1570177__F1 Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability 841 637 581 836 842 317 331 735 718 PMC1573858__F1 AT1 receptor signal transduction pathways that result in transcriptional NA neuromodulation (a) and increased firing rate (b) in neuronal cultures 3725 2353 2444 1621 7054 PMC1592599__F1 TNFA signaling pathway leading to apoptosis or proliferation of the cells 7124 8717 7186 8772 PMC1603434__F6 TSC1/TSC2 in the canonical Beta-catenin signaling pathway 10023 7249 1499 PMC1636849__F8 Schematic summary of the signaling pathway leading to Nanog repression 2885 79923 6657 2627 132625 PMC1705980__F2 Schematic model of autophagic regulation 5163 5728 2475 PMC1766919__F1 Signalling footprints of the TNF/TNF-R superfamily 8717 7186 7188 8772 PMC1769518__F1 Complement system consists of about 30 proteins that can be activated by 3 different cascades 718 717 720 721 PMC1770611__F2 Axin in Wnt signalling 999 1499 324 PMC1774279__F1 Two major intracellular pathways cause apoptosis 596 317 637 PMC1774601__F2 Death receptor mediated (extrinsic) pathway of apoptosis 355 637 8772 8717 PMC1781062__F1 CCM2 as a Scaffold for p38 MAPK Activation 83605 4215 5606 5608 6416 8550 9261 PMC1782125__F2 Signal transduction of TNFRI 7124 8717 7186 8772 4049 4055 5970 PMC1782564__F6 Hypothesized asthma cascade in hapten immune contact sensitized mice, consist of B-1 cell- to immunoglobulin M- (IgM) to complement-driven airway responses 1431 727 196 PMC1782796__F7 Affinity maturation, a turning point between life and death for germinal centre (GC) B cells: a working hypothesis 958 80709 51411 PMC1783813__F3 Physiology and immunology of the cholinergic antiinflammatory pathway 7124 7099 929 3146 PMC1785270__F6 A model illustrating the positive and negative regulation of PanK2 activity 56342 80025 79646 53354 1376 PMC1808970__F3 AIRE expression is controlled by the lymphotoxin pathway 5970 5971 326 PMC1850660__F1 Summary of established Beta-catenin pathways 1499 999 2932 324 PMC1851929__F8 Proposed model for the activation of oligodendrocyte apoptosis by MHV infection 355 8772 637 1616 581 596 PMC1868540__F1 Canonical Wnt Signaling Pathway 4041 1499 324 PMC1869626__F2 Pathway analysis was performed using PathwayStudio software by importing three of the 32–up-regulated genes in our list 6319 196 440 PMC1874671__F2 Genomic organization of the CDKN2A locus and description of involvement of its transcripts (p16INK4a and p14ARF) in the Rb and p53 pathways 1029 4193 1021 1019 PMC1890551__F1 Eumelanin synthesis pathway and gene duplications in vertebrates 4948 1638 7306 PMC1890551__F4 Pteridine synthesis pathway and gene duplications in vertebrates 2644 6697 5805 5066 7498 PMC1891745__F1 Diagram illustrating Functional JAK STAT PathwayThis “JAK STAT” pathway appears to be ubiquitous amongst vertebrates 100187761 2056 2885 PMC1895802__F1 TGFB signaling pathway and mechanisms of inhibition during leukemogenesis 4087 4088 4091 4092 4089 PMC1900132__F1 HCMV MIE promoter/enhancer and its cis-acting elements 100187761 7528 6667 2077 PMC1905066__F5 CRP and mannan-binding lectin (MBL) on complement activation 716 715 717 735 718 4200 1401 PMC1905373__F7 Mechanism of complement-dependent haemolysis via the lectin pathway: role of the complement regulatory proteins 716 717 718 PMC1934518__F2 Ligands identified for EpCAM and possible functions related to them 999 928 4072 PMC1952644__F1 Alternative signaling: cardiomyocyte B1-adrenergic receptors signal through EGFRs 1956 1839 6714 2869 2870 5350 PMC1952649__F2 Two tales concerning skeletal muscle 3479 3481 207 PMC1955177__F3 Cell death in the cardiovascular system 3479 3480 664 85451 2475 PMC1955758__F2 How both apoptotic death and immunity may be triggered by dsRNA 6041 6035 8772 572 581 355 PMC1971124__F4 BDCA2/FcERIG Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells 5132 613 640 4067 2534 3932 6850 7535 29760 27040 64170 PMC1992444__F3 Interaction map of the Notch signaling pathway 5663 145873 3955 3458 3280 84667 PMC2013861__F4 Signalling pathways activated by the RXFPs 59350 122042 51289 339403 1956 6714 PMC2066195__F10 IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice 834 7097 7099 4615 3554 3553 PMC206993__F9 SPARC-mediated regulation of and coupling to the TGFB signaling system 6678 4087 4088 1017 PMC2075035__F2 Scheme of the Leloir pathway 130589 2592 101448070 2582 PMC2080843__F5 Simulation of the Apoptosis pathway under FasL stimulation (black starred line), bacterial only (red circled line) and both (blue triangled line) 841 581 836 842 PMC209410__F1 The EXT proteins and HS biosynthesis 2131 2132 2135 51083 1431 PMC209410__F2 A working model of mammalian bone development 3549 6608 2132 2131 PMC2094118__F1 The HIF1 pathway in normoxia (A) and hypoxia (B) 7428 3091 51147 PMC209479__F1 Corticotroph SOCS-3 as an intracellular suppressor of cytokine signaling 3976 6774 5053 5443 PMC209479__F2 Inhibitory effects of SOCS-3 and SHP-1 on LIF-mediated gene expression 3976 3717 6774 PMC2118421__F7 Proposed model of RasGRP1 in FcɛRI-mediated signaling 2534 6850 4067 2885 387 PMC2151350__F2 Model for renal pathology in Dent's disease (due to a loss of ClC-5) The small peptide PTH (parathyroid hormone) and various forms of vitamin D (VitD; bound to their binding protein) pass the glomerular filter into the early proximal tubule (A) 5741 7421 56302 PMC2168916__F7 Regulation of the AHR-XRE pathway by NRF2 9817 1545 196 405 PMC219066__F1 Tocopherol biosynthesis in plants 9453 100682260 22944 3258 PMC2195651__F1 Fas (death receptor) signaling pathway and its inhibition 355 3265 8772 253868 PMC2195865__F1 Extrinsic and intrinsic cell death signaling pathways 581 637 8772 PMC2228275__F3 A signaling network links genes regulated by GCs in CEM cells 4830 3397 8407 6723 3065 10138 9063 619410 4522 811 PMC2230579__F10 Left, the mechanism, described by , for the proapoptotic function of TSP1 or 2 7422 948 7436 6714 355 PMC2238720__F2 Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions 4615 51135 3654 7189 5971 5970 PMC2242712__F1 Phenolic lipid synthesis in A 367 411 414 410 717 PMC2254485__F5 Tumour growth and metastasis: Role of NPP2-catalyzed reactions 1499 7471 4018 84890 PMC2291100__F1 Proposed biosynthetic pathway of Tcm PKS and a comparison of hypothetical intermediates for two possible folding pathways 2147 1690 8205 PMC2349985__F1 Role of Leukotriene B4 Receptors in Rheumatoid Arthritis 3553 4050 4049 PMC2373983__F1 Human T-Cell Leukemia Virus Type 1 Blunts Signaling by Interferon Alpha 3454 3455 6773 3659 10379 9636 2633 PMC2374452__F5 Molecular pathways of rheumatoid arthritis-related cartilage destruction as reflected by the in vitro model 2920 2919 2921 1311 7058 729230 1380 6611 1235 7852 4319 4321 PMC2374589__F1 Programmed cell death can be executed via extrinsic and intrinsic pathways depending on the stimulus leading to apoptosis 637 56616 27429 2021 PMC2375600__F2 From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy 3952 3630 6774 2308 PMC2383880__F7 A logic-based diagram of signalling pathways central to macrophage activation 9021 3717 5970 4791 7124 355 837 4000 7097 PMC2396219__F2 PPARA and AMPK activities in the cancer cells exposed to energetic stress 3667 5465 4193 7249 7248 6009 572 2475 PMC2413267__F1 Wnt Signaling and Skeletal Development 4041 4040 324 1499 PMC2413330__F3 Working hypothesis on the mechanism by which plasminogen activator inhibitor-1 (PAI-1) causes hepatic steatosis 3082 7124 4547 PMC2424193__F6 Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells 3308 3569 3565 3329 7124 3586 4790 1080 9641 8517 7186 3458 7189 2923 6955 6774 PMC2430694__F2 Inflammatory Pain: The Cellular Basis of Heat Hyperalgesia 7442 4803 3479 PMC2432088__F1 WNT SIGNALING PATHWAY: AGING GRACEFULLY AS A PROTECTIONIST? 2932 6010 1499 PMC2440498__F1 Signaling cascades initiated via TLR2- and TLR4-dependent activation 7096 7097 7099 10333 4615 114609 29110 7189 3661 PMC2492871__F5 Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR1 (A-B) 5270 5329 1999 93649 PMC2493210__F1 Schematic diagrams of small intestine mucosa in normal and infected intestines 64127 671 7099 54472 PMC2517296__F1 The co-ordinated activation of pro-inflammatory signalling pathways by TLR ligands and the pro-inflammatory cytokines TNFA, IL-1 and IFN 3466 8717 4615 7186 7188 7189 5728 PMC2537575__F5 NFKB canonical signaling pathway from IPA 1950 4803 7039 4049 114609 7186 3932 7535 5336 5970 5971 PMC2553363__F1 Extrinsic and intrinsic pathways of hepatocyte apoptosis 581 637 572 PMC2556095__F4 TGFBeta-related signalling pathway controlling Myc activity in keratinocytes 4609 1874 5017 PMC2556095__F6 In the canonical TGFB signalling pathway, ligands signal through type I and II transmembrane protein kinase receptors 7040 4087 4088 4092 4089 7018 3664 5017 PMC2564980__F7 Higher expression of genes involved in O-glycan synthesis in the carcinoma compared to the papillary adenocarcinoma tumors 55568 2590 51809 PMC2572128__F1 Simplified model of translation initiation 1977 1975 7458 10278 1999 2001 1983 9669 PMC2573957__F1 Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination 3929 7099 929 7293 7292 114609 54472 4615 51135 11213 3661 3656 7189 PMC2582809__F1 Role of cytokines in DC and T-cell interactions 324 149233 50943 PMC2593438__F7 AKT reduces the growth-inhibitory function of TGFB1 149951 5970 7127 1952 55363 54954 PMC2593566__F3 JAK/STAT signaling pathway and SARS-CoV 3716 10379 6773 6772 PMC2605641__F2 Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration 2730 2729 57716 2539 1728 PMC2606944__F9 Role of Small GTPases and AvB5 Integrin in Pseudomonas aeruginosa–Induced Increase in Lung Endothelial Permeability 387 1499 1003 PMC2610259__F1 Chronic colon colitis model 2810 9817 4094 1728 PMC2612938__F2 Pathways by which Mgrn1-mediated ubiquitination could modulate melanocortin receptor regulation of pigment production and energy metabolism 181 4159 472 4157 8455 4160 23295 PMC2613033__F1 Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study 9415 1896 3992 54898 PMC2628394__F15 Biological network representing the schizophrenia p-value ranking 2018 6662 1977 8013 1048 3134 6256 3091 9429 290 PMC2631308__F1 Insulin resistance 3643 3667 8660 208 2308 355 7038 PMC2633249__F3 Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases 267 5879 572 PMC2635127__F2 JNK/p38 non-Smad pathway 7189 23118 4088 4089 PMC2637758__F5 Pathways and networks associated with HSPA9, PHB, and ABCB6 7416 6774 7040 3569 7157 5925 6597 954 6595 1869 3065 354 PMC2645904__F3 Schematic representations of potential signaling pathways involved in serum-deprived retinal ganglion cell-5 cells 2113 10891 8463 213 34 5465 2353 6256 3458 1773 1950 3758 7042 80146 PMC2646147__F6 A model for three pathways of TLS in mammalian cells 1362 100187761 353497 51426 PMC2647614__F2 Novel Insights into Lung Transplant Rejection by Microarray Analysis 3566 7448 7057 3932 940 3559 3560 3558 3565 3567 6418 PMC2647860__F7 p53, Cyclin-dependent Kinase and Abnormal Amplification of Centrosomes 5347 995 994 993 PMC2654353__F7 From the extracellular matrix to HIF and from HIF to the extracellular matrix 2475 4017 6651 7852 4015 4312 PMC2654747__F2 Summary of enzyme-catalyzed thyronamine deiodinase reactions 1735 8205 1733 1734 PMC2655379__F8 Potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle 3479 3667 207 5166 5132 PMC2656226__F9 Complement pathway altered in disease 10747 720 721 730 1431 1380 1378 PMC2663056__F4 Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling 7124 1950 3667 841 836 4149 PMC2663399__F5 DNA Damage Tolerance: When It’s OK to Make Mistakes 5111 56852 545 84126 PMC2664743__F4 Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity 627 406921 7472 PMC2665757__F6 EXT/HSPG pathway involved in both peripheral and central chondrosarcomas 2132 2131 3549 PMC2666018__F12 Differential Requirement for MEK/ERK and SMAD Signaling in PAI-1 and CTGF Expression in Response to Microtubule Disruption 1956 6714 387 5494 PMC2666381__F1 TLR signaling and the role of epithelium in corneal innate defense 7100 4049 7099 4118 4615 51135 54106 51284 51311 7189 7098 3550 3661 3665 3383 PMC2666388__F1 DHA, NPD1, and BAPP-derived AB peptide signaling circuits in homeostatic aging and in AD 6653 348 102 95 PMC2666391__F2 Toll-Like Receptors and Corneal Innate Immunity 4049 7099 7100 100187907 51284 51311 54106 7098 3569 3383 4615 929 PMC2666844__F5 Simplified schematic of hepatocyte growth factor (HGF)/MET signaling pathway 3082 2549 2885 PMC266780__F7 Scheme to illustrate the separate functions and regulation of conventional nonsarcomeric myosin IIA and myosin IIB 4018 4803 6010 1356 PMC2670105__F1 IMP impedes Ras mitogenic signaling by limiting KSR1 complexes 1950 673 8844 PMC2672887__F1 Model for the regulation of type 1 interferon signalling by filamin B 5879 9636 3466 PMC2673908__F2 Unifying model of Wnt signaling with regard to cardiomyogenesis 7471 7481 4040 4041 2932 387 1499 PMC2675492__F1 Biochemical schematics: This figure maybe regarded as the biochemical underpinning of our model 6667 7039 4312 PMC2676316__F2 Isoprenoid Metabolism and the Pleiotropic Effects of Statins 387 10493 5879 PMC2677399__F2 Nuclear Factor KB, Airway Epithelium, and Asthma 7124 3603 4050 5970 5971 PMC2677410__F2 Novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell 5728 7248 7249 5371 6009 2475 PMC2677752__F1 Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development 3603 3202 2022 PMC2678718__F1 Conversion of subendothelial macrophages into cholesterol-laden foam cells is believed to constitute the foundation of the atherosclerotic lesion 4067 2534 8685 968 PMC2679052__F7 Diagram summarizing differences in expression of interaction genes enriched within the KEGG p53 signaling pathway, and possible interactions of corresponding proteins with the androgen receptor 5728 207 1026 595 PMC2680180__F1 Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins? 4280 23410 23409 23408 PMC2680672__F2 Regulation mechanisms for Itch-mediated Th2 differentiation.TCR triggering plus CD28-mediated costimulation results in the activation of MEKK1-JNK signaling pathway, which induces the serine/threonine phosphorylation of Itch 940 920 2534 80762 717 83737 3726 PMC2683584__F1 Control of Cell Number in the Sexually Dimorphic Brain and Spinal Cord 367 581 8772 PMC2685460__F7 Induction of Distinct TLR2-Mediated Proinflammatory and Proadhesive Signaling Pathways in Response to Porphyromonas gingivalis Fimbriae 929 5879 114609 4615 PMC2688657__F5 Growth signal pathway 2534 3725 8195 1950 1956 2002 6722 7039 2885 4609 4149 9770 4150 PMC2689134__F4 Pathogenesis of holoprosencephaly 4838 9241 6469 6608 10120 659 4087 4088 4090 4086 4089 8928 2619 PMC2690992__F2 Signaling control of mesenchymal and amoeboid cell phenotypes 4739 1795 6010 5879 58504 PMC2691965__F2 Toll-like receptor (TLR) activation 7097 7096 7099 10333 929 7100 114609 4615 51284 7098 7189 3661 PMC2694443__F8 BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway 4040 4041 50964 PMC2695202__F2 Emerging anti-inflammatory therapy 6347 2919 3066 3579 729230 6590 PMC2695762__F2 Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity 64127 64170 8915 10892 7096 7097 51311 10333 7100 54106 7099 7098 51284 PMC2695927__F4 Bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease 929 671 4975 3929 PMC2698322__F4 Key proteins regulated by PKB that are involved in metabolism (yellow); cell cycle progression (green); cellular growth (red); cell survival and apoptosis (blue); angiogenesis (orange) and neurological processes (purple) 7249 7248 572 4193 PMC26984__F1 Proposed pathway of EGF-induced cell proliferation of ER− breast cancer cells 1950 1956 5266 1021 1019 PMC2699281__F3 Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease 3383 7412 183 718 PMC2701885__F2 Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence 7098 3455 3454 7297 3716 8651 9021 29110 3661 3665 PMC2704469__F8 Scheme indicating expression of Tcf4 proteins and effects of Wnt–Beta-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte 324 6925 5156 10215 116448 PMC2704572__F1 Complement effectors generated during activation contribute to various mechanisms that limit tumor growth 718 720 5648 10747 717 721 PMC2704572__F2 Some complement proteins can accelerate tumor growth 720 2271 5648 10747 717 721 PMC2707271__F5 Proposed mechanism for MAP4K3 cell death signaling 572 1975 8491 581 PMC2709856__F1 It’s all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection 7099 114609 4118 4615 7189 7187 10454 3661 23118 PMC2713571__F1 Proposed cuticle pigmentation and sclerotization metabolic pathway in T 7054 1644 1356 PMC2715971__F2 Interaction between insulin and interferon-alfa signaling pathway 3455 3454 7297 3716 6773 6772 PMC2716541__F6 Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation 8795 1647 5728 355 4616 596 27244 10370 1027 894 PMC2716750__F1 Gene regulatory networks in kidney development 6092 9353 652 2303 2296 717 367 2668 2297 5979 183 10252 7481 5076 PMC2719424__F8 DUOX1 involvement in TLR-mediated IL-8 production in response to bacterial stimuli 7039 6714 6868 1956 53905 3576 PMC2719801__F2 Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways 6517 3643 5295 5290 8660 5894 5293 1977 6009 5596 5599 9448 5170 50488 6300 6722 6844 10580 10938 23624 2889 5781 9021 5578 3991 5211 5588 3551 2997 PMC2721377__F1 Molecular toll-like receptors (TLRs) of the human gastrointestinal (GI) tract which act as sensors and are the first responders in the major pathway by which the immune system detects infection or damaged tissue 7097 4049 929 7099 7100 3725 PMC2723817__F1 Targeting lung inflammation: novel therapies for the treatment of COPD 2919 6347 3066 3579 729230 6590 PMC2724396__F1 Modified Lee-Heinrich model of wnt pathway 1499 2932 324 PMC2724661__F1 Complement system in AD 718 727 730 966 735 PMC2724780__F1 Bile acid modulation of death and survival transduction pathways 8772 637 572 842 836 PMC2727911__F1 Activation pathways of the complement system and complement regulatory proteins 717 718 5648 10747 716 721 729 730 966 PMC2728081__F2 Regulation of B-cell entry into the cell cycle 5266 613 6850 4067 PMC2729321__F3 Is NFKB a good target for cancer therapy? Hopes and pitfalls 7188 7189 7186 7187 1540 4295 5970 5971 PMC2729336__F3 Transcriptional control of HC and amacrine cell development 256297 5629 6496 121643 4760 343472 3670 PMC2730119__F3 Scheme showing the role of different signaling pathways in mediating the effect of high K intake on ROMK and BK channels in the CCD 6446 65266 65125 PMC2731131__F10 Schematic summary of LPS-triggered programmed cell death in human endothelial cells 7099 4615 847 8772 637 PMC2733081__F4 MAPK Signaling Cascade is a Central Hub in the Regulation of Cell Cycle, Apoptosis and Cytoskeleton Remodeling by Tripeptidyl-Peptidase II 83729 3655 5801 6197 1874 2005 6722 4609 PMC2733092__F4 Intersection sets of the differentially expressed miRNAs constitute complex interaction networks.A Venn diagram illustrating the production of intersection sets from three miRNA target prediction algorithms 652 5228 7422 4609 5989 860 5468 5087 6662 4654 55553 406958 PMC2739389__F3 Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape 355 8772 841 637 572 836 581 596 842 790 317 PMC2739756__F3 FXR regulation of enterohepatic circulation of bile acid 9965 2264 100187761 3172 1810 PMC2740411__F8 Transcriptional regulation of cell cycle arrest gene p21 by ZBTB5 9925 54880 6667 PMC2747168__F1 Acp-group transfer catalyzed by PhTYW2 55253 127253 84890 PMC2747759__F1 Monoclonal antibodies in the treatment of pancreatic cancer 8772 637 581 PMC2748726__F1 Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas 958 3662 604 639 545 1111 7157 1026 671 PMC2751538__F7 Proposed VEGF-C/D cell signaling pathway to transduce LAM cell proliferation 7424 7249 2475 PMC2754156__F3 LPS signal transduction via the MyD88-dependent pathway 3929 929 114609 4615 51135 7189 PMC2757047__F3 Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity 1020 223117 885 348 7436 7291 PMC2757227__F1 Regulation of ENaC and CFTR by SGK1/Nedd4-2 1080 6446 5163 5164 PMC2757955__F10 Proposed model of IGFBP-3 modulation of growth factor receptor activation mediated by S1P 6497 1950 1956 3486 8877 PMC2758485__F1 Wnt/PCP signaling and its effects on organogenesis 7481 57216 6395 585 1499 PMC2758708__F2 Diagrammatic representation of non-canonical Wnt signalling in a mammalian cell 6422 6425 6423 115908 7474 9620 81839 57216 5754 1857 1856 1855 22881 387 64750 57154 PMC2765790__F7 Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes 338340 10135 23411 PMC2768486__F10 Possible mechanism by which BMPs and estrogen regulate GNRH production by GT1-7 cells 10097 654 655 652 650 PMC2769052__F9 Schematic representation of a potential mechanism of IFN-Gamma- and STAT3-dependent cell growth modulated by TSC2/mTOR signaling pathway 7249 3458 2475 6774 PMC2769250__F3a Trafficking of Heme and Porphyrins in Metazoa 210 7390 7389 10058 1371 PMC2773646__F1 Nodal signaling pathway 4838 4087 4089 5494 8498 8928 PMC2774738__F3 Specification of cell fate in the mammalian cochlea 652 182 23493 23462 3280 3955 2138 6657 2737 2260 26281 388585 100188776 474 6469 3399 3398 3397 3714 2253 2261 PMC2775047__F1 TLR Mediated Immune Responses in the Urinary Tract 929 114609 4118 4615 7189 PMC2776288__F2 Crosstalk between ionizing radiation-induced apoptosis and NFKB pathway 7186 581 472 637 331 PMC2776723__F6 Integration of activated transcription factors with the upstream signaling network during CB1R-induced neurite outgrowth 1050 6772 6775 7421 4602 6774 4800 5080 1385 7067 5447 3096 6714 860 PMC2776748__F1 A, Schematic diagram showing intra-cellular functions of the Bcl family of proteins 7124 3576 572 637 581 317 PMC2778230__F3 Apoptotic signaling in aging muscles 3398 8717 637 581 8772 317 331 2021 PMC2780838__F1 The complement cascade 721 720 5648 716 717 718 727 1378 729 730 735 PMC2781822__F2 Resolution of immune activation defines nonpathogenic SIV infection 5132 51284 4615 2475 3661 3654 7189 PMC2782488__F3 Cytokine signaling modules in inflammatory responses 9021 6774 7808 6347 2919 PMC2782725__F2 Cell cycle and acute kidney injury 581 637 2021 PMC2783241__F2 Kidney development: from ureteric bud formation to branching morphogenesis 26585 652 7481 2668 5979 2625 847 10252 3082 1950 PMC2783774__F4 miRNA process pathway 22937 54487 79753 5901 23405 6895 27327 PMC2783967__F6 Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin 1384 10554 2194 22944 1545 83401 247 10965 51083 5465 2100 3992 3283 7069 23205 3638 23175 6646 9415 PMC2784766__F3 Complex role of the PLAU-PLAUR pathway in the airways 7040 3552 3553 5270 5340 5328 1956 5329 5159 PMC2785495__F3 Response of heterogeneous ribonuclear proteins (hnRNP) to ionizing radiation and their involvement in DNA damage repair 3190 4193 472 545 PMC2786808__F8 Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice 5728 324 7248 7249 2475 PMC2787666__F2 The complex network of protein–protein interactions of Ape1 5378 11284 842 7422 1111 2178 PMC2788007__F1 Simplified representation of the complement cascade 715 717 727 PMC2790850__F2 Aberrant Myc expression causes mammary cancer 2064 57646 672 4609 PMC2793049__F2 Leptin signaling and leptin resistance 3717 25970 7249 7248 9021 6714 6774 2475 PMC2794560__F1 Metabolic pathways of tamoxifen 8205 1559 1557 PMC2798710__F1 New roles for Notch in tuberous sclerosis 7249 7248 4851 2475 6774 PMC2801866__F3 Thrombospondin-1 (TSP1) binds to two receptors on endothelial cells that inhibit NO signaling 948 961 4827 2534 6714 PMC2804071__F4 Joubert syndrome: insights into brain development, cilium biology and complex disease 6469 200894 5156 585 582 57545 80184 6103 261734 4867 23322 51176 1499 PMC2807212__F3 TGFB superfamily and FGF signaling pathways 4092 10818 2885 4089 4091 PMC2808140__F2 Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host 7189 9053 5598 PMC2810618__F8 Signaling network model for heart valve development and remodeling 1839 4772 2064 2065 1956 3037 PMC2810660__F1 Autophagy and NFKB fight for fate 5966 7186 7187 PMC2811067__F2 Some of the stress response transcription factor pathways with homologs in N 196 3091 405 4094 9817 PMC2811646__F3 Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN 2810 9817 4094 2944 54658 PMC2812788__F1 HDL, ABCA1 and ABCG1 transporters in cholesterol efflux and immune responses 929 7099 3931 4615 9619 19 3553 PMC2818240__F5 Oxidative stress and glutathione in TGF-Beta-mediated fibrogenesis 4087 4088 4089 6667 PMC2820587__F3 AURKA interactions 6790 1499 4193 595 9076 581 PMC2820725__F4 Redox signaling responses in DCs and T cells during T cell activation 940 941 942 3932 27040 2885 PMC2821977__F1 All steroids derive from cholesterol, which can be synthesized within the brain for de novo neurosteroidogenesis () 706 6770 1583 PMC2826040__F5 miR-223 is implicated in the CREB signaling pathway 3479 3480 56927 5516 781 PMC2826212__F2 An intricate gene regulatory network controls OL differentiation 3065 7528 6934 3398 3400 116448 10215 3066 6663 388585 PMC2830120__F3 Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection 2534 3717 6774 PMC2830572__F1 TNF A inhibits erythropoiesis by direct and indirect effects 2056 2624 3091 2057 PMC2832309__F2 WWOX gene and gene product: tumor suppression through specific protein interactions 3082 2066 51741 3725 860 324 PMC2833197__F7 Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway 22926 468 7494 7422 PMC2833311__F6 Signaling pathways involved in Alpha-TEA-induced apoptosis in human ovarian cancer cell lines 2064 2065 355 581 PMC2835492__F4 Regulation of MUC4 expression 3458 6497 4585 PMC2836529__F3 Neurotrophin actions on the endothelial cell 4803 627 7422 4313 PMC2837360__F1 Canonical Wnt/Beta-catenin pathway (modified after ()) 284654 22943 324 2932 PMC2838317__F8 Differences between TRAIL- and AD5-10-induced signaling pathways 353128 64851 780912 114475 450086 8081 8772 637 2021 PMC2839454__F2 Too Old to Fight? Aging and its Toll on Innate Immunity 929 7097 7096 5879 PMC2843003__F3 Epicardial-Myocardial Signaling Directing Coronary Vasculogenesis 1499 2260 7484 6469 6608 2736 2626 PMC2844056__F2 Ingenuity pathway analysis and expression profiles of genes involved in apoptosis that were uniquely up regulated in ER+ cells in response to EPA 5885 6772 5074 55023 25873 PMC2844056__F6 Insulin receptor cascade was uniquely up regulated in ER− cells when treated with AA 2100 4089 6689 1827 9370 7422 3662 9618 4050 3977 3565 4049 1441 3037 2908 4908 10657 4015 7441 PMC2844217__F1 Schematic representation of the biosynthetic pathway of emetine, cephaeline, and related alkaloidal glucosides in P 10873 4199 4200 PMC2844927__F3 Routes of interaction between epoxyeicosanoid and endocannabinoid signaling pathways 59341 7442 2166 PMC2848307__F1 Survival pathways with their cross-talk and immune regulatory mechanisms are shown in this pictorial representation of the Reed-Sternberg (R-S) cell 958 978 5337 3569 2475 6774 4609 6714 PMC2849133__F4 Main targets of RhoA and ROCK, involved in organization of the cytoskeleton 387 3985 2670 PMC2849832__F1 IFNG signaling through the JAK/STAT1 pathway 3458 3716 3717 6772 3383 3659 3660 1026 5696 5698 3460 3459 PMC2850427__F2 Simplified Overview of the Purine Metabolism PathwayThe scheme is derived from KEGG Pathways hsa00230 (purine metabolism) and hsa00240 (pyrimidine metabolism) 7372 5471 100 4860 191 PMC2854298__F8 AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1 83939 7466 26574 6774 207 PMC2855646__F7 Summary of biosynthetic pathway for O-mannosyl glycans on A dystroglycan in mammals 29954 10585 55624 PMC2857179__F1 Mechanisms and pathways targeted by mutations in MPN 7173 2056 2057 4352 4351 2885 3717 867 4763 54790 PMC2857326__F7 TGFB induces apoptosis in human B cells via transcriptional regulation of BIK and BCL-XL 613 355 7049 8772 638 581 PMC2860235__F7 FunCoup subnetwork of candidate cancer gene RPA1 surrounded by functionally coupled known cancer genes 5395 9733 4595 55743 PMC2861866__F3 Hypothetical model linking multiple biological pathways in the development of SS-like disease based on differentially expressed genes identified in lacrimal glands by global microarray analyses 5894 6774 6778 1278 6387 1520 567 1512 347 348 6772 PMC2862880__F3 Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer 1583 3283 1586 8644 6716 6715 8630 1645 1646 PMC2865489__F1 The estradiol-synthetic pathway and nuclear receptors 706 6770 1583 367 PMC2865574__F3 Wnt signaling is a complex pathway, believed to be involved in the regulation of divergent processes, including the maintenance of pluripotency and commitment to differentiation 1499 595 6275 8313 PMC2869521__F1 Role of BCR signaling to NFKB in ABC DLBCL 84433 695 29760 6850 973 7189 23118 2475 974 613 PMC2872497__F4 Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment 4838 4087 4088 4089 PMC2878081__F7 Schematic overview of the pyruvate/isocitrate cycle and OGC, important components of the pathway regulating glucose- and glutamine-stimulated insulin secretion 23152 5091 2746 PMC2881756__F7 Model illustrating the role of WDR3 in mediating cross-talk between ribosome biogenesis and p53-mediated cell cycle regulation 10885 4193 6135 PMC2882531__F1 Retinoids for Treatment of Retinal Diseases 24 145226 50700 6120 9227 5959 6121 PMC2882796__F1 Does Activation of the Blood Coagulation Cascade Play a Role in Malaria Pathogenesis? 2821 7018 3553 7412 3383 PMC2886300__F2 Role of ROS in TNFA induced endothelial dysfunction 9618 3383 6497 PMC2888475__F1 Cellular apoptosis pathways and intervention by both cellular anti-apoptotic proteins and viral proteins encoded by oncolytic Ad, HSV and VV 619537 8772 637 596 842 PMC2893543__F4 Schematic overview of costimulatory receptors and their ligands 958 939 970 940 29851 PMC2894843__F3 Ingenuity Pathway Assist (IPA) analysis of significant genes involved in cell death 1636 2934 3958 2247 3606 4615 1439 1514 1508 58484 6774 472 1634 5800 790953 836 PMC2897145__F7 Molecularly and temporally separable lineages comprise the hindbrain roof plate and contribute differentially to the choroid plexus 27040 151449 1356 PMC2897904__F1 Proposed mechanisms of HDACi-induced apoptosis in colon cancer cells involving the mitochondrial pathway 10013 9759 10014 9734 51564 83933 581 317 PMC2900209__F6 Inflammation Stages in the Acute Lung Injury in Mice 8569 5604 5605 2246 2260 2885 2872 5894 1385 5922 1843 10491 5058 10746 4215 5062 6416 3725 11184 5609 5606 5608 10598 7186 1649 7124 7189 4790 PMC2903975__F1 TLR signalling pathways: All TLRs except TLR3 share a common initial signalling pathway through MyD88 to the IRAK1/2/4TRAF6 complex 114609 4615 51135 3656 7189 23118 7187 3661 3665 7099 7098 7100 7096 7097 10333 51311 51284 54106 PMC2906263__F3 Suppression of IFN-induced Jak-STAT signaling in hepatitis C 11274 9021 3716 7297 10379 3276 3455 3454 163702 PMC2908766__F2 PI3K dependent signal pathway 940 572 5163 2475 2932 PMC2909319__F9 Model: a Src-Tks5-Nck signalling pathway in invadopodia 6714 5266 2885 PMC2909548__F3 Protein-protein interaction comprising the transforming growth factor B signaling pathway 7046 26273 3958 10140 9886 8878 1281 1290 83871 5880 8767 5341 83452 8065 5998 1278 7314 1848 3725 140901 5216 2872 85415 1942 22800 1147 PMC2913337__F2 Cross talk of the Nodal/Cripto-1 signaling pathway with Wnt, hypoxia, Notch, Oct-4, and Nanog signaling pathways 4838 9573 2657 7481 8324 4851 4087 4088 1499 79923 PMC2916219__F5 A model for regulation pathways responsible for RN and AM symbioses 4609 79902 51199 PMC2919275__F3 PD-1 Pathway in Tolerance and Autoimmunity 324 920 50943 PMC2921074__F1 Modulating immune function and controlling inflammation 3717 6774 7124 3146 PMC2923430__F9 Immune Response 718 5648 717 727 729 730 735 PMC2925066__F1 Major Apoptotic pathways 355 8772 27429 581 2021 56616 637 317 PMC2926929__F1 The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin 4018 4026 55750 PMC2929244__F6 Defects in physiologically driven actin signaling at hippocampal synapses in Fmr1-KO mice 5662 6714 387 PMC2932677__F1 Diversity and Plasticity of Th Cell Types Predicted from Regulatory Network Modelling 3558 324 3559 3560 940 59067 PMC2933570__F1 Coordinated upregulation of cytoprotective genes occurs as a result of Nrf2 activation 57716 7296 2729 2730 2539 PMC2933676__F3 The canonical Wnt signaling pathway 4693 4041 367 1499 7008 PMC2935201__F3 Platelets, Petechiae, and Preservation of the Vascular Wall 627 1950 7422 1956 1499 PMC2939298__F1 Schematic diagram of androgen biosynthesis 1583 3284 6715 1646 1586 8644 3293 5959 PMC2940983__F1 Histone GH2AX and Poly(ADP ribose) as Clinical Pharmacodynamic Biomarkers 545 472 3014 9656 672 PMC2943859__F5 Death receptor signaling and its interdigitation with the mitochondrial pathway of apoptosis 8772 637 331 PMC2945208__F3 KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS 79923 6657 993 1021 1017 1871 PMC2945462__F1 Complement cascade is comprised of the Classical, Alternative, and Mannose Binding Lectin pathways 717 716 720 729 730 1431 PMC2956119__F1 This figure shows the two distinct but ultimately converging apoptosis signaling pathways in mammals 355 637 581 842 836 317 8772 PMC2956119__F3 The many roles of FAS receptor signaling in the immune system 355 637 842 836 317 8772 PMC2957845__F6 Scheme of the Wnt signalling pathway including proteins from the RT-PCR array 64840 6424 53944 80319 440193 10023 324 1499 607 56998 2033 5308 7088 51701 26190 8061 894 595 896 4040 PMC2963142__F1 TLR signaling pathway and downstream effector molecules 7100 7099 7098 54106 51311 51284 114609 4615 51135 7189 7187 3661 3665 PMC2964746__F4 Selected signal transduction pathways that affect AS of transcripts of genes important in cancer 355 6426 6732 PMC2965566__F2 Transcriptional control of invariant NKT cell development 920 2534 7535 8915 1796 9046 PMC2967529__F8 Model for vertebrate limb induction and outgrowth 9260 2253 2255 6910 2263 PMC2972700__F1 Wnt Signaling During Fracture Repair 6422 4041 6259 4920 22943 324 1499 6714 51176 PMC2975271__F9 Schematic model for regulation of mTOR pathway signaling through interaction of the p53 target Plk2 with TSC proteins 10769 7248 7249 2475 PMC2975924__F3 Eph/ephrin signaling regulates intestinal cell positioning and proliferation 1856 23002 5266 1947 PMC2978917__F7 Signaling pathway and transcription factors involved in HPR1 gene expression in cancer 1956 2113 6667 121599 1958 PMC2980759__F1 Examples of the inter-relationship between host, tumor, and environmental factors (pharmaco-epi-bio-genomic triad) that determine the response to tamoxifen in an individual patient (phenotype) 1565 6714 6817 1576 PMC2984459__F1 Schematic overview of Toll-like receptor (TLR)4 signaling pathway 3929 7099 4615 6772 7189 929 PMC2984612__F1 Cellular FLICE-inhibitory protein: an attractive therapeutic target? 355 8772 637 790 PMC2994781__F1 Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis 1725 7018 7054 PMC2996483__F3 Oncogenic Notch1 Signalling 5728 3575 2475 PMC2997801__F1 Positioning NFKB in multiple myeloma 3479 3480 4055 958 1540 7187 7186 5266 6774 PMC3000288__F1 Schematic representation of the As cycle in the environment and plants 1244 4363 5091 367 6476 PMC3008185__F1 Two-loop model of iADE 3717 3716 6774 6772 6773 9636 7187 29110 7054 PMC300841__F1 Usurpation of the Ras signaling pathway by reovirus 1956 2064 2885 6714 PMC3021368__F2 PI3K in immune system 930 613 940 29851 PMC3025764__F4 Metabolic regulation by FOXO1 in skeletal muscle 5166 7249 7248 4023 948 2475 6256 PMC3027599__F5 Ingenuity pathway Analysis network 1 depicting relationships among up-regulated genes in SB300 infection group relative to that of SB1117 infection group at 8 hours 23643 6289 5366 3662 2331 255738 PMC3030733__F1 Interventions in nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 signaling pathway 9817 1728 4094 PMC3035679__F3 Human inherited and mouse experimental defects in the cholesterol biosynthesis pathway that cause myelin disorders 1717 19 1593 PMC3036178__F1 Lymphotoxin and the immediate tumor necrosis factor (TNF) family 7124 4055 7186 7187 5971 PMC3038194__F1 Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer 1950 7039 10718 3084 9542 1839 367 1956 2885 572 2475 2002 3725 2353 PMC3039708__F2 T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics 5728 4615 7189 6772 2475 PMC3039708__F3 T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics 940 324 50943 PMC3044944__F6 Hypothetic model for TGF-Beta-regulated KLF4 proteolysis 4087 4088 999 324 9314 PMC3045367__F1 Exploring the Evolutionary Relationship of Insulin Receptor Substrate Family Using Computational Biology 3667 8660 8471 208 PMC3051174__F3 TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock 4615 3661 7099 PMC3057147__F1 Top associated network functions for miR-141 and miR-200c 5069 136319 2628 PMC3059437__F1 Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk 6470 4397 7298 1719 PMC3062538__F5 The regulation of IgA class switching 5284 85480 958 7045 7040 PMC3063194__F1 Elicitation of innate immune response in EBV infection 7097 7098 51284 4615 3663 7187 10010 29110 3661 3665 3569 54106 PMC3066468__F7 Scheme of cross-talk interactions between liver IR and TIM-1 signaling 3553 2919 2920 PMC3068560__F4 Proteome of sickle cell disease: insights from exploratory proteomic profiling 51762 6950 5340 PMC3069071__F7 Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells 6608 637 331 581 PMC307558__F1 TGFB signaling pathway 387 993 4089 1017 PMC3075710__F3 Regulated fatty acid synthesis and metabolism during cell differentiation 5111 51703 2167 2171 2182 29956 7038 717 729 PMC3076281__F2 Sphingolipid effects on intrinsic and extrinsic apoptotic pathways 355 7124 8772 8717 572 581 637 331 PMC3077244__F5 The proposed signalling pathway 5163 5728 1499 PMC3077378__F7 Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling 1956 2322 3717 2582 PMC3077544__F2 Akt regulates numerous biological functions by phosphorylating distinct protein substrates 6502 9744 572 7249 2932 4193 5058 2475 PMC3078022__F1 Tumor heterogeneity and strategies to overcome kinase inhibitor resistance in cancer: Lessons from melanoma 673 369 8315 PMC3078450__F5 Network annotation of genes differentially expressed according to the CD133 status in HT-29 using ingenuity pathway analyses 2261 648 182 1029 3596 2260 324 1499 89780 3371 22976 PMC3080979__F2 Partial hepatectomy stimulates anandamide production through a pathway involving conjugation of arachidonic acid and ethanolamine by FAAH 2305 5163 5728 2166 PMC3081824__F5 Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing 2523 2524 2526 2527 2530 8790 55343 10690 84750 170384 23509 23275 2762 2517 2519 PMC3083340__F3 Top network affected by MAA 2353 572 6774 842 8743 10319 598 5037 841 5925 3909 836 2327 367 8826 3688 6715 3480 3655 10580 1000 4067 3732 9564 PMC3084000__F1 Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003) 64399 5727 84976 6608 8643 85455 100420631 2735 2737 2736 27148 51684 894 2305 PMC3089810__F2 Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy 4067 2885 6714 638 695 PMC3094097__F3 Examples of cellular receptors that sense infection and cell death 3146 54106 7099 7097 3661 PMC3096494__F1 Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells 7099 929 4827 4211 6667 5087 PMC3096496__F6 Model depicting the generation and consequences of ROS-mediated base damage 79661 252969 8930 4913 7374 PMC3096978__F4 Functional network connections between HRneg/Tneg signature genes 3458 7124 10563 5999 5594 6348 3586 1236 207 6667 5600 1404 53405 58 23265 1937 6234 6774 2335 PMC3099707__F10 Dual MC4R signaling model to account for “rescue” of Ay phenotype by alterations in MC4R trafficking 4160 8455 23295 7251 PMC3102606__F4 Pathway context for RME modules found in glioblastoma 2033 2064 4193 1956 7157 4763 1029 445347 5728 12 4288 PMC3104012__F1 Summary of the common pathways underlying neurodegenerative diseases and cancer that are mediated by miRNAs 693122 89795 472 5309 23621 1021 351 1788 1789 4170 599 6624 5728 4609 836 25855 PMC3104248__F2 Genetic mutations of signaling molecules implicated in mTOR pathway (red Xs) 92335 5163 6009 PMC3107984__F3 Genetic analysis of biological pathway data through genomic randomization 5019 3155 622 56898 PMC3113646__F6 TGFBeta-and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR) 2475 5266 1977 7078 7077 PMC3113675__F7 Arginine methylation of G3BP1 regulates both Ctnnb1 mRNA and canonical Wnt/Beta-catenin signaling 89780 10146 1857 1499 3276 PMC3117038__F1 The roles of CARM1 and coactivator methylation in DNA damage signaling pathway 472 672 10498 581 PMC3118418__F1 Which FGF ligands are involved in lens induction? 5015 655 652 6496 2301 5629 PMC3121749__F8 Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions 10637 7044 4838 9350 6997 4087 4088 4091 4092 4089 6497 3725 2353 PMC3124345__F2 Schematic representation of the possible mechanisms leading to ovarian cysts in female patients with ORD 1595 5447 1586 1588 PMC3124513__F6 Integrated Bio-Entity Network: A System for Biological Knowledge Discovery 3558 3497 2357 2185 3777 1050 7170 PMC3124877__F1 Pathway of alcoholic injury resulting in the direct production of oxidative stress and the LPS-TLR pathway that culminates in production of cytokines and other inflammatory processes that result in hepatitis of the liver 1571 7099 4615 PMC3127159__F2 TPO signaling pathway 7173 3717 596 PMC3131061__F1 TIR and NFKB signaling pathways 613 10913 7098 51135 3654 7189 4615 PMC3131135__F1 Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection 7097 7099 51311 51284 54106 7098 4615 51135 3656 3654 7189 7187 3661 3665 PMC3132733__F1 Pathway-Based Association Analyses Identified TRAIL Pathway for Osteoporotic Fractures 7187 8772 8837 PMC3132735__F7 CCN2 Is Required for the TGFB Induced Activation of Smad1 - Erk1/2 Signaling Network 1490 6714 4086 2113 2313 PMC3134295__F1 Apoptotic Process 8772 581 637 317 PMC3134378__F2 Regulation of HIF-1A by the MAPK pathway 5879 3845 673 768 PMC3134378__F3 Regulation of HIF-1A by the PI3K pathway 3845 5728 2475 5371 7249 7248 768 PMC3135880__F5 Survival and proliferative effects of Dilong extract on RSC96 Schwann cell 2668 4803 627 5111 595 3479 3480 3383 5340 759 847 PMC3137974__F1 Signal pathway activation by the main TLR and CLR receptors that detect Candida 7099 7097 4118 4615 6850 7098 51135 3656 54106 7189 10892 64170 3661 3665 3663 PMC3139189__F1 Intrinsic pathway of apoptosis 581 666 56616 572 90427 638 790 PMC3144530__F1 Schematic overview of proposed G protein-coupled oestrogen receptor 1 (GPER1) signalling 1839 2852 1956 6714 PMC3147800__F9 Model showing the cooperative function of LMO7 and Rho in the activation of MRTFs 4018 6010 4008 PMC3149315__F1 Biosynthetic pathway of GSL and the CIRES procedure 51083 8869 84002 53947 9331 338707 8705 PMC3149747__F2 Extensive feedback and feedforward loops between Ras signaling and miRNAs 7832 10252 10253 27250 6239 388 356 317 3667 4609 PMC3154472__F1 Identification and Phylogenetic Analysis of Heme Synthesis Genes in Trypanosomatids and Their Bacterial Endosymbionts 1371 210 5498 7390 2235 7389 PMC3156870__F1 Resistance to RAF inhibitors in melanoma 5159 3480 673 5728 10000 595 90427 PMC3157228__F7 Scheme for changes in the molecular pattern of inflammatory signaling, antigen processing, and presentation in attacked myofibers 3459 3460 6772 5696 4261 PMC3157425__F4 Apoptosis Induced by Piroxicam plus Cisplatin Combined Treatment Is Triggered by p21 in Mesothelioma 2305 699 29127 3959 1033 PMC3157706__F1 Molecular pathways in LSCs of CML 5728 240 2475 1499 PMC3158628__F1 Unlinking of the Golgi ribbon during G2 inhibits the recruitment and activation of Aur-A at the centrosome trough a novel mechanism 5347 84962 994 PMC3158866__F1 Toll-like receptor signaling pathway 3146 7100 7096 7097 10333 7099 7098 54106 114609 4615 7189 51135 7187 3661 3665 PMC3159104__F4 Extrinsic signal pathways for regulating pluripotency during reprogramming 3976 652 4090 4086 4087 4088 4089 6774 1499 59330 3977 659 PMC3159521__F2 Pre-B-cell-receptor signaling is regulated by a feed-back loop via Ikaros and Aiolos 613 25 2322 PMC3161051__F7 Rad6B/Beta-catenin regulation in breast cancer cells with autocrine Wnt activity 324 1499 4040 847 51199 4041 PMC316396__F7 Axial and appendicular cartilage 6469 5075 2626 PMC3166463__F3 Innate immune signalling at the mitochondria 7096 7097 7099 7189 57506 51295 79671 345611 114548 3603 PMC3168677__F2 MicroRNAs in Rheumatoid Arthritis 7099 7097 10333 3654 7189 4615 51135 3553 3569 PMC3169997__F1 Epithelial cell cycle arrest in G2/M and epigenetic changes in fibroblasts coordinately promote kidney fibrosis 8213 8437 100 PMC317073__F7 Regulation of TNF-R1signaling pathways during apoptosis 8717 8772 7186 637 PMC317204__F8 Schematic diagram illustrating a model for the antagonistic roles of Dp110 and DPTEN in Drosophila growth control 8471 3667 8660 PMC3173146__F8 Summary and working model 1956 6714 3431 PMC3173728__F1 In this figure we show the two main pathways to apoptosis, and their interaction through the molecule BID, since death receptors activate the intrinsic pathway by activating BID 596 355 637 581 8772 317 PMC3175103__F4 Dysregulated TRK Signalling is a Therapeutic Target in CYLD Defective Tumours 4908 4915 4916 7189 4914 7332 1540 5597 207 5598 596 PMC3175442__F2 Map of pentose phosphate pathway (Genego Metacore) overlapped with quantile-normalized estimations of protein abundance 2821 22934 6120 7086 PMC3177306__F2 The canonical vertebrate Wnt signaling pathway 22943 4040 4041 324 1499 28996 PMC3177754__F4 RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity 64127 3553 834 3661 64170 8915 PMC3178431__F6 p63 signaling in cancer cells 2932 7249 324 5728 6009 1499 6774 PMC3178610__F5 Determining Signalling Nodes for Apoptosis by a Genetic High-Throughput Screen 4792 7124 6357 1958 2778 476 6513 2542 PMC3180062__F8 Schematic Model of apoptotic signaling induced by targeting EphA2 gene by siRNA in MMC 1969 8772 637 581 842 836 PMC3185234__F1 Enterohepatic circulation of the bile 1581 64240 64241 PMC3185763__F1 Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) pathways that lead to apoptosis of HIV infected helper T cells 920 355 7852 8772 637 581 PMC3185810__F2 Alteration of the IFN-I signaling pathway by HTLV-1 3455 3454 3716 7297 6773 PMC3192251__F2 NPC and CF converge on multiple intracellular trafficking pathways 1080 4864 10577 PMC3192861__F10 A schematic model of GC-mediated acute activation of NHE3 via SGK3 2638 23678 2642 10110 6446 PMC3193407__F1 NFKB activation by the canonical pathway 4018 1950 1956 PMC3199787__F4 Graphical representation of the IL-6 signaling pathway reveals significant gene expression changes following sarin-induced seizure 3929 7186 3717 85451 3725 2 PMC3206202__F9 Expression Profiling Reveals Differential Gene Induction Underlying Specific and Non-Specific Memory for Pheromones in Mice 6955 572 581 PMC3209254__F9 The multiple mechanisms by which Sox2 regulates the osteoblast lineage 6657 1499 648 324 2932 PMC3213687__F2 Appearance frequencies of genes in the mTOR signaling pathway 2475 253260 3091 1975 6009 7249 1977 673 PMC321455__F9 A model depicting the relationship between the p19Arf-p53 tumor suppressor pathway and the Rho GTPase signaling module in the regulation of cell proliferation and transformation 5879 387 998 5266 PMC3218720__F2 Receptors that sense danger signals released from neighboring injured retinal pigment epithelial (RPE) cells 3146 7097 7099 54106 3553 PMC3224136__F7 Schematic pathway showing a possible role for STC2 in affecting the PERK signalling pathway 83939 468 8614 467 PMC3225028__F2 WT1/EGR1-mediated Control of STIM1 Expression and Function in Cancer Cells 1958 7490 6786 PMC3228224__F1 Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA 7249 7248 2475 PMC3236216__F5 Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways 27343 11201 3665 9447 90865 PMC3241725__F3 Bacterial manipulation of host pro-survival pathway 10392 664 596 836 PMC3241928__F8 Beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas 5728 673 5300 4286 1499 4199 PMC3241960__F5 Sarcolemmal actin assembly and nuclear signaling 6010 4118 6722 PMC3243341__F3 Conversion of major constituents in the stem cuticular wax biosynthetic pathway 717 95 1431 718 PMC3245506__F6 Network of differentially expressed genes in transgenics at 12 months (parametric and nonparametric approaches) 914 9134 1380 4151 2208 3159 4026 7037 3839 4605 351 136319 324 22974 1029 6489 3161 11214 22808 890 10451 1903 2889 900 6241 PMC3246786__F2 The role of CYLD in canonical and noncanonical NFKB pathway 958 7186 7187 1540 23118 5971 PMC3247643__F6 Overlay of significant canonical pathway and the connectivity in the molecular mechanism of cancer, with the eight genes in IPA canonical pathway and with the genes in Network (I) that differentially altered in PCB exposure 1356 51330 85451 6876 1875 3074 3845 10018 596 7040 5887 6288 3488 3678 4248 894 4179 3688 3918 51561 948 5683 481 5444 3949 PMC3248020__F9 Schematic representation of S100A7-mediated signaling that inhibits proliferation and motility in ERA+ breast cancer 6278 1499 2932 999 PMC3248149__F1 Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence 4193 595 581 PMC3248879__F1 Network images of FTO and candidates genes 818 23466 3797 8621 4915 57486 2743 79068 4137 9736 23673 5728 6844 5217 23635 1039 9581 5518 9099 84276 PMC3251560__F9 Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes 6835 140458 4149 6722 23198 3681 4656 2844 91833 7227 147011 PMC3252343__F4 Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner 3429 84285 3434 4938 4599 11274 6772 9636 PMC3252742__F4 Apoptotic pathway in cardiac myocytes 842 836 2021 331 56616 572 581 PMC3252833__F1 Fas-induced apoptotic signalling pathway 355 637 596 836 581 331 842 PMC3253886__F4 IRF signaling pathway that was generated from pathway analysis of proteins with significant fold changes across both studies 7098 57506 3661 3441 3586 PMC3257580__F1 Kruppel-like factors in lymphocyte biology 920 10365 51621 9314 7071 51274 PMC3261582__F1 JNK signaling enhances the compensatory proliferation of the neighboring cells, stem cells or cancer stem cells (CSCs) 9314 6657 4609 595 960 PMC3262331__F3 Schematic signaling pathway mediated by the L-CBM complex in NK cells.Notes: The L-CBM complex acts in the canonical NFKB activation pathway through activating NK cell receptors (NKR) such as Ly49H, Ly49D, NK1.1, NKG2D, FcGRIII, etc 4615 7409 5879 8915 10892 PMC3264131__F1 Metabolic pathway of C 2597 5183 5091 PMC3269300__F1 DN Tregs employ multiple mechanisms to exert antigen-specific control over immune responses 942 941 3458 1493 920 PMC3269833__F6 Potential regulatory mechanism of the identified gene switches for breast cancer 4070 51655 2099 2064 84707 595 PMC3270095__F4 Regulatory network for PACAP-responsive genes 3315 9314 468 2353 22936 5817 7832 PMC3274456__F3 Lipopolysaccharide (LPS)-dependent and nuclear factor (NF)KB-mediated activation of proinflammatory cytokines 7099 929 3929 4615 7189 PMC3277529__F1 Proposed model for TIMP-1–mediated suppression of the Wnt/Beta-catenin pathway via let-7f in human mesenchymal stem cells (hMSCs) 4040 4041 324 2932 8313 967 1499 7076 PMC3278592__F3 The pleiotropic effects of erythropoietin in infection and inflammation 2056 2057 613 PMC3279943__F1 PI3K and STAT3: a New Alliance 7249 6009 6774 PMC3281082__F7 ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer 619501 780 2475 406977 PMC3281277__F1 Proteolytic processing of the BACE1 substrates APP and NRG1 3084 1950 102 23621 PMC3281591__F4 Mitochondrial-dependent apoptosis 637 596 2021 842 PMC3284544__F4 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis 3929 7097 929 7099 114609 4615 54472 7189 23118 10454 2002 PMC3285438__F5 Simplified signaling pathway of the effects of resveratrol involved in metabolic control in the skeletal muscle 5950 3667 23411 PMC3285581__F7 Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium 4582 4057 4487 4488 1499 PMC3287363__F7 Working model of ID/anemia-suppressed hippocampal IGF signaling 3091 3480 3667 2002 2308 7249 2475 PMC3293584__F1 Schematic of folate-mediated one-carbon metabolism in the cytoplasm and nucleus 1719 6470 7298 PMC3293632__F1 Control of the EGFR pathway and cell cycle entry by miRNAs 1956 6772 6774 208 5925 PMC3298530__F7 Tentative scheme for luteolin regulation of the IGF-IR signaling pathway in HT-29 human colon cancer cells 3667 995 595 4193 891 PMC3302843__F10 Hypoxia Reduces Arylsulfatase B Activity and Silencing Arylsulfatase B Replicates and Mediates the Effects of Hypoxia 411 3091 1277 3162 5328 PMC3305973__F2 Sixteen genes associated with enzastaurin response were established by pathway analyses and prediction of drug response using an eight-gene signature 3643 4734 79083 6233 PMC3307887__F1 Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells 3952 6774 960 PMC3309495__F2 Pathway analysis of altered metabolites upon paroxetine treatment 7345 2998 2645 183 1803 PMC3311926__F1 Mitochondrial regulation of apoptosis 581 637 331 PMC3312283__F2 This figure shows three novel intracellular signaling pathways involved in the pathogenesis of IBD 3553 3717 207 6774 7412 3383 PMC3314482__F1 Chk’ing p53-deficient breast cancers 545 472 1017 9241 PMC3315682__F1 Serine biosynthetic pathway 26227 29968 5723 PMC3317170__F3 Proposed models for the activation of intracellular TLR9 and TLR3 by Leishmania 7098 3569 54106 7124 6352 3627 3458 PMC3317641__F6 Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes 3852 3861 390 2013 2113 3157 2114 54578 133 4609 3556 7057 4053 6699 1316 29968 7052 27097 9314 10381 PMC3318683__F12 A model of MMP-9 sorting and trafficking in activated macrophages 5873 967 3916 PMC3321152__F4 Non-apoptotic functions of apoptosis-regulatory proteins 8717 8737 8772 11035 PMC3321306__F1 Gene expression network of the heritable transcripts in the nuclear factor kappa B signaling pathway 8717 196 3146 4869 PMC3321461__F1 Proposed mechanism for overcoming HNSCC resistance to EGFR antagonists using PI3kinase/Akt/mTOR and NFKB-IL6-STAT3 pathway inhibitors 3569 1956 6774 PMC3322159__F8 JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells 3099 891 6888 PMC3323831__F1 TLR signalling 7097 7096 7100 10333 7099 4118 929 4615 54106 51284 51311 7098 7189 3661 3665 8772 PMC3325001__F2 Modes of Hh pathway signaling 6608 51684 2735 5727 PMC3328281__F1 Molecular changes of serous carcinogenesis 673 2064 3845 7157 5925 1029 898 208 5290 9732 672 PMC3329985__F4 Top Networks Associated With MK-801 Treatment Identified by Ingenuity Pathway Analysis 4204 5914 7157 2810 3064 6616 4609 7443 6389 PMC3335850__F1 Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology 8741 8837 637 581 596 8772 PMC3338341__F1 Repressed (left) and activated (right) canonical HH signaling pathways 6608 50846 3549 6469 2735 2932 2736 2737 596 894 595 PMC3338341__F2 Mechanisms of activation of HH signaling in hematological cancers 50846 3549 6469 6608 238 2735 2932 596 894 595 9429 PMC3340722__F2 TNF related apoptosis-inducing ligand and its receptors in ocular tumors 8772 637 331 PMC3342043__F1 TLR2 signaling 7097 7096 4615 114609 51135 3654 3656 3660 3659 6772 7189 3661 3665 23118 PMC3342401__F7 Summary diagram of the proposed ADM signaling pathway in retina 133 10266 10268 PMC3344687__F7 Schematic diagram of the Heme/TLR4/MyD88 and/or TRIF hypothesis in ICH 7099 4615 3661 PMC3355898__F2 Somatic alterations in the PI3K pathway in prostate cancer 5295 9863 5290 8503 5728 8821 207 PMC3356304__F6 Personalized Pathway Enrichment Map of Putative Cancer Genes from Next Generation Sequencing Data 1956 5728 7157 8626 PMC3357465__F1 Gene mutations involved in PTC carcinogenesis 2885 673 3240 4914 2002 6722 PMC3360100__F3 Examples of signal transduction pathways in astroglial cells following P2Y1R activation 367 2668 6774 842 836 PMC3360882__F8 Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals 951 2932 1499 PMC3364135__F1 EpCAM and its potential role in tumor-initiating cells 1366 2274 324 1499 51176 4072 79923 6657 4609 PMC3365841__F11 Pituitary cells express GPCRs that engage the cAMP signaling pathway 1392 2691 7432 6750 717 PMC3366009__F8 T cell signaling pathway used by A2 and A9 7535 6850 2625 3458 PMC3366472__F2 TLR-4 signaling in cancer 3146 929 114609 4118 3661 4615 PMC3366822__F7 Schematic diagram showing the role of NDRG1 in inhibiting the EMT via regulation of the TGFB/SMAD and Wnt pathways 999 1499 4087 4088 4089 595 PMC3367549__F2 Canonical (left) and noncanonical (right) WNT signaling pathways 4040 4041 2932 23002 1499 6010 2353 3725 PMC3367549__F4 BMP signaling pathway and regulation of SMAD activity 4090 4086 4091 4092 4089 PMC3367865__F6 Molecular Biology of Lung Cancer: Clinical Implications 6608 2932 324 2735 2736 2737 3280 PMC3368918__F1 Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis 1717 120227 1594 7421 1593 1591 2638 PMC3369606__F2 Role of DCs in the pathogenesis of GVHD 3383 7412 3553 941 942 940 29851 958 355 PMC3369892__F8 Summary diagram of the proposed adrenomedullin (ADM) signaling pathway in the retina 133 10266 10268 PMC3374088__F1 Caspase-8 has a crucial role in the regulation of DRs 7124 8717 8737 11035 8772 PMC3376184__F3 Function network built upon genes selected from the identified genetic component 1356 5522 627 1312 7187 2353 3363 5580 817 1814 2066 815 2316 2557 2904 2567 175 PMC3376408__F1 IL-2 release by DCs stimulation of PRRs triggers the calcineurin/NFAT pathway via PLCG2 and intracellular Ca2+ flux 958 4615 7099 7189 64170 5336 6850 PMC3376735__F1 Logic of TGFB signalling from the membrane to nucleus 1051 467 4089 6497 PMC3376977__F2 NK cells sense tumors, course of disease and treatments 3135 7428 3458 3383 6772 613 PMC3378977__F1 Summary of the suggested mechanism for the regulation of MMPs and TIMPs in the paracrine interplay between SCC-25 cells and fibroblasts 960 4312 7078 PMC3380339__F1 Cross-regulation between the IL-1B/IL-18 processing inflammasome and other inflammatory cytokines 3553 834 9447 57506 64170 8915 3146 54734 6348 6364 3661 PMC3383335__F2 SnoN Signaling in Proliferating Cells and Postmitotic Neurons 324 2308 1641 PMC3388714__F2 Layers of DC-mediated tolerance 940 941 942 3586 7097 7124 PMC3390969__F2 Impact of a negative regulator on pathogenesis and the development of sepsis, secondary to acute insults 9332 929 4615 7189 PMC3394417__F1 Sample gene regulatory network 5900 10928 5337 PMC3394960__F10 A schematic model for the role of ANXA2 in the pathogenesis of adenomyosis 999 302 1499 7422 PMC3397358__F1 Viral genes and the activation of apoptosis 355 637 83939 6041 581 PMC3404158__F2a Ubiquitination and Phosphorylation in the Regulation of NOD2 signaling and NOD2-mediated Disease 64127 331 23118 257397 PMC3404195__F6 Proposed regulatory mechanism of ERB in colitis-associated colon cancer 3458 3570 3716 6774 6772 1499 857 4582 4583 PMC3408141__F8 The molecular pathway required for NOD2-dependent autophagy 5518 64127 8408 55054 PMC3408195__F9 A novel KRAS-initiated pathway leading to the activation of VMP1 in cancer cells 3845 207 2737 81671 PMC3408740__F1 Alarmins: awaiting a clinical response 3146 6279 6280 7097 3553 PMC3409287__F3 ITIM-mediated signaling function of IDO 3620 2534 9021 3654 5971 PMC3409471__F2 Clinical Implications of Cancer Stem Cell Biology in Hepatocellular Carcinoma 1499 51701 4072 6868 2627 1045 2932 2274 324 51176 3091 9429 5728 6774 1956 PMC3410320__F1 Survival and proliferative effects of Dilong extract on RSC96 Schwann cell 2668 627 4803 5111 3479 3383 1950 5340 847 PMC3412720__F3 JAK-STAT signaling pathway 8027 10379 2057 5292 1387 1154 5777 4609 1441 894 896 1439 200734 10252 PMC3412720__F4 AKT signaling pathway 5294 5515 5170 8517 4790 1147 4792 207 3320 7533 PMC3414384__F1 Actin cytoskeleton as a sensor and mediator of apoptosis 8772 90427 8739 572 638 581 637 317 PMC3415586__F2 Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity 942 958 3662 PMC3415708__F4 A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer 4128 351 4967 6392 PMC3417476__F1 Cyclic AMP-mediated induction of Treg cells and suppression of effector T cells 50943 920 3932 1445 PMC3418709__F1 Hepatitis C, Porphyria Cutanea Tarda, and Liver Iron: An Update 1544 7389 2235 3077 148738 PMC3418714__F1 B-cell receptor signaling in CLL 4067 695 6850 2885 29760 2534 5336 PMC3419619__F8 Protein kinase CD (PKCD) activation by proteolytic cleavage downstream of tumor necrosis factor (TNF) signaling in dopaminergic neurons 8717 8772 7186 PMC3428099__F1 FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators 1950 1956 84985 222584 2475 673 2885 572 4170 2002 4609 PMC3429058__F1 HDL promotes regression 19 6363 1236 948 PMC3429121__F2 Metabolic flux through the purine salvage pathway in L 9615 353 84890 435 2766 8833 PMC3429622__F4 TRBP in the exogenous and endogenous RNAi pathways 54487 29102 27161 PMC3430120__F2 Summary of pathways controlling muscle protein synthesis (MPS) and muscle protein breakdown (MPB) 3479 4617 2475 260431 PMC3437743__F1 Glutathione and modulation of cell apoptosis 637 581 2021 7186 8717 8772 PMC3437941__F1 Integration of B cell responses through Toll-like receptors and antigen receptors 613 4615 51135 3654 7189 PMC3437946__F8 Synthesis and degradation of dopamine, norepinephrine, and serotonin 7054 4129 1312 1621 4827 7166 4128 PMC3438185__F9 Novel Levamisole Derivative Induces Extrinsic Pathway of Apoptosis in Cancer Cells and Inhibits Tumor Progression in Mice 8772 355 637 PMC3438932__F7 The role of dimeric TIR platform for the inhibition and activation of MyD88 signaling pathway 4615 51135 3654 3656 PMC3439567__F2 P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation 351 1956 6714 2885 6010 2316 PMC3439854__F2 Transcriptional regulation of PDPN expression 3553 5728 2353 3725 6772 6774 4089 4087 4088 10630 PMC3440872__F4 Model showing a role for Yap in governing cardiac growth and survival by interlinking the Hippo, IGF, and Wnt pathways 4485 9113 26524 3480 324 2932 1499 PMC3442876__F2 Autophagy in immunity 3553 3146 8878 10241 4077 345611 PMC3442893__F1 Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment 407011 5625 2475 22863 5289 30849 PMC3448082__F1 A simplified model of the feeding regulation hypothesis involving the hypothalamic neuropeptide signaling pathway 5443 885 5697 PMC3461903__F2 New molecular insights into peripheral T cell lymphomas 5155 5154 5159 5156 847 7297 3717 3716 100187761 2885 3265 6774 6778 6772 PMC3461933__F1 Looking in the miR-ror: TGFB–mediated activation of NFKB in glioma 1956 6657 3397 3976 5155 1950 4792 PMC3466981__F2 Ubiquitin ligase complexes SCF and APC/C in ubiquitin-mediated proteolysis of regulatory molecules essential for cell cycle control 324 1021 1019 1017 PMC3469658__F5 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes 7431 3313 4001 7157 4609 7846 3553 3936 351 6249 PMC3475803__F7 A model depicting ATM- and NEMO-mediated NFKB activation upon accumulation of prelamin A isoforms 5970 472 2919 PMC3478095__F2 Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease 29102 54487 23405 26523 192670 27161 192669 PMC3478307__F2 Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K 4615 5170 51135 7189 PMC3479191__F5 Multilevel factors cooperatively perturb pathways 3265 11186 1026 369 1029 1870 595 5594 5925 4609 8200 657 1875 4090 4086 2033 4092 64750 57154 3400 5522 3625 3624 1311 83729 PMC3484277__F1 Downstream signaling of the IGF-1R 2885 3667 5728 7249 6009 2475 3481 3479 PMC3493591__F5 Constitutive ß-Catenin Signaling by the Viral Chemokine Receptor US28 387 2932 1499 595 324 PMC3496878__F4 Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling pathway in cell proliferation in solid cancer 5728 7248 7249 2475 1978 1977 PMC3497295__F1 Selected signaling pathways in renal cell carcinoma (RCC) 6009 7428 2056 1950 317 PMC3499814__F3 Type I IFN signaling pathway and inhibition by influenza A viruses (Figure adapted from ) 3716 6772 9636 10379 3665 PMC3501016__F1 Finding a New Regulator of the Blood Coagulation Cascade♦ 5058 7018 7035 PMC3502626__F7 A theoretical model of synergistic interactions between resveratrol and HDAC inhibitors is presented 23411 5970 841 842 836 PMC3504364__F2 Methotrexate (MTX) mechanisms of action in the folate metabolic pathway 5243 1244 4363 9429 6573 4552 4397 1719 3630 2356 8836 4524 4522 PMC3504715__F8 Cytokine-induced CITED2/MYC/E2F3/p21CIP1signaling in lung cancer 7039 1956 7046 4609 10370 3065 1871 6667 PMC3507180__F2 Hypothetic regulation of gene expression by HNF-4A by spherical cell shape in FLC-4 cells 130 217 7130 1244 355 7424 7026 3172 5465 4609 9612 PMC3508273__F4 The role of tumor-associated macrophages (TAMs) during tumor angiogenesis 2247 8205 3586 PMC3508619__F1 MYC proteins and the p53/MDM2/p14ARFpathway 4613 4193 581 PMC3508723__F8 Model of Tat/Beta-catenin interaction in astrocytes 3458 8313 1499 246751 PMC3509680__F3 Functional roles of the arenavirus Z protein in the viral life cycle 5371 1977 3661 PMC3513983__F3 Major signaling pathways regulating RSV-induced NFKB and IRF activation in airway epithelial cells 7098 57506 10010 29110 3661 PMC3515920__F1 Retinoid refractoriness due to phosphorylation of retinoid X receptor alpha (RXR A), and its restoration by acyclic retinoid (ACR) in liver carcinogenesis 49 6256 595 PMC3517178__F2 Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression 6609 54472 8837 3553 6095 4313 5111 5428 1063 8600 7852 PMC3518257__F7 14-3-3 signaling canonical pathway from IPA 867 2885 2670 9049 572 2002 581 PMC3518431__F2 Autophagy modulation as a potential therapeutic target for diverse diseases 8408 5266 23192 4077 PMC3521387__F8 ILOCi detected genes from CAD and their maps in 'cytokine-cytokine receptor interaction' pathway 5008 4049 355 6295 5447 5617 PMC3527539__F7 Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells 1950 1956 406947 857 4087 7157 999 595 1499 6925 PMC3527608__F6 Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms 2695 355 8772 637 596 572 331 581 PMC3527886__F2 Network of biglycan signaling in osteoblast differentiation and stabilizing role of biglycan in skeletal muscle 4090 4086 4089 4087 4088 1499 89780 PMC3531730__F6 Proposed model for the signaling pathway mediating NFKB activation induced by C-type lectin receptors 6850 5336 64170 7189 8915 10892 PMC3531868__F1 Receptors for IL4 and IL13 are comprised of four different subunits, IL4RA (green), gamma chain (Gc; purple), IL13RA1 (red), and IL13RA2 (yellow) 3565 3596 3597 6778 PMC3533556__F7 IL-13–induced airway mucus production is attenuated by MAPK13 inhibition 1179 5603 6778 4586 PMC3534167__F2 Hodgkin lymphoma 958 7128 1540 4792 4794 5971 5966 602 PMC3535349__F1 Iron homeostasis in absorptive enterocytes, macrophages, erythroblasts, and hepatocytes and its routes of circulation in the organism 9843 2242 7036 3077 5093 PMC3536347__F2 Pharamcologic activators and enhancers of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) 50964 22943 4040 4041 324 PMC3539150__F1 Schematic diagram illustrating the specific cascade and signaling pathway in LPS-primed macrophages stimulated with MSU, silica, or alum salt crystals 8544 3553 3603 PMC3539299__F1 The phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt pathway and its relationship to the androgen receptor (AR) based on the results of three papers published recently by the laboratories of Charles Sawyers, Damu Tang and Hong Wu 4123 5728 2475 1958 2146 2289 367 PMC3540985__F1 CYTOKINES, INFLAMMATION AND COLON CANCER 7099 4615 7189 5970 PMC3541667__F5 Hypothetic model explaining how KDM6 may contribute to definitive endoderm differentiation 7403 23135 7473 22943 1499 PMC3542934__F1 TGFB signalling pathway 2200 7046 7048 4087 4088 4089 387 PMC3543090__F8 Model showing the effect of miR-182-5p on the DNA repair pathway 672 11200 7158 466 5884 6604 1027 PMC3544784__F1 Insight into the role of CRMP2 (collapsin response mediator protein 2) in T lymphocyte migration 6387 7852 2932 1020 PMC3546894__F1 Cytokine regulation of immune response cell phases through gender specific pathways 3458 3569 3586 PMC3547110__F3 Amplifying phase 29760 7006 100124696 695 7189 9846 5336 PMC3551464__F1 Control of cell adhesion during neuronal migration 6478 5649 23245 1600 5906 460 1000 PMC3552145__F10 PGN-induced miR-132 and miR-212 in TLR signaling 51135 7096 7097 7100 7099 10333 929 4615 3656 3654 7189 PMC3553670__F3 Signal transduction pathways and activation of the innate immune response 3949 3383 7097 4615 114609 4118 7098 51311 51284 PMC3554339__F1 Actions of Nec-1 and its derivatives in a mouse system 7124 3458 8717 7186 7188 8737 1540 8772 11035 PMC3555201__F3 HMGB1 in the tumor microenvironment and hypothesis of HMGB1 functioning via NF-kB and epigenetic pathways 3146 7099 4615 3845 7189 51135 6774 8205 5970 1786 25855 PMC3558460__F1 Signal activation of human somatostatin receptor subtype-2 by membrane-displayed somatostatin 6752 2821 95 PMC3559342__F3 Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin 57167 6181 8822 27339 322 1791 8626 9101 551 6624 4345 1395 84636 29 PMC3561841__F1 Why stress is BAD for cancer patients 5728 572 4609 PMC3564224__F2 Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 140885 961 6714 664 596 PMC3564914__F1 Transcriptome analysis of bitter acid biosynthesis and precursor pathways in hop (Humulus lupulus) 3652 587 586 PMC3567816__F1 A summary of the newly proposed inflammasome activation pathway including PKRs' recently found role 3553 3146 114548 22861 58484 9447 PMC3567829__F9 miR-486 sustains NFKB activity by disrupting multiple NFKB-negative feedback loops 8717 10454 23118 83737 1540 PMC3571350__F10 Schematic model of IFN-induced apoptosis in WISH cells 7297 3716 8772 841 836 6772 6773 10379 PMC3572677__F1 Scheme of apoptosis pathways 8772 637 331 PMC3573419__F1 Germinal-center B-cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) derived from normal germinal-center centroblasts 596 2475 5728 3621 4193 PMC3573419__F2 Activated B-cell-like (ABC) diffuse large B-cell lymphomas (DLBCLs) are derived from plasmablasts that are characterized by a block in differentiation 596 973 974 613 4772 2475 84433 6774 4615 27086 639 604 6689 695 6850 PMC3576710__F1 Transmembrane protein UNC93B1 (black spring-like shape) associates with various toll-like receptors (horseshoe-like shapes) in the endoplasmic reticulum to help load them into vesicles coated with COPII for transport to the Golgi 54106 51284 7098 PMC3577986__F4 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy 159296 3586 6774 3717 574511 3458 22891 55054 9966 345611 120892 375611 4485 55600 219771 PMC3578363__F1 G1 cell cycle control by the pRB pathway 1017 1021 1019 PMC3580164__F3 Transcriptional integration of mitochondrial biogenesis 23411 5465 7528 8408 23410 PMC3581421__F8 Coupling and S1P signaling in mesenchymal cells 8877 9294 1901 PMC3584306__F3 Obesity Pharmacotherapy: Current Perspectives and Future Directions 23237 4160 1392 7200 6492 PMC3584589__F9 Two mechanisms by which miR-200a regulates the activity of Beta-catenin 999 1499 9839 6935 PMC3585436__F4 p110D PI3K mediates the effects of CSF-1 or EGF via RhoA and PTEN in macrophages and some solid tumor cells 1950 6714 387 5728 PMC3588168__F1 Simplified schematic of signaling pathways driving resistance to BRAF inhibitors 5159 3480 673 369 5728 PMC3589238__F6 Networks wherein various signaling pathways epigenetically affected by MXC exposure intersect and the relationships between affected molecules 3480 1356 3265 3643 3479 5728 5241 4149 4087 PMC3589551__F2 Regulation of LTP induction in the hippocampus by NRG1-ErbB4 signaling through suppressing Src enhancement of NMDARs 3084 2066 6714 PMC3590793__F1 ATR barrier to replication-born DNA damage 5884 84126 11073 545 PMC3592845__F7 Gli1 Deletion Prevents Helicobacter-Induced Gastric Metaplasia and Expansion of Myeloid Cell Subsets 6469 2735 3553 PMC3592971__F3 Four simplified signaling pathways 269 353500 4089 4086 8321 6932 7474 1856 2932 1499 4091 8312 4040 324 1452 7040 7046 4087 4609 22943 6667 1030 2475 5567 3361 2778 114 5601 7186 7133 3667 487 3551 3953 6774 9021 808 3717 818 PMC3594971__F3 c-jun N-terminal kinase (JNK) pathway in postmitotic migrating neurons 5879 4131 1641 PMC3598331__F4 Hindlimb transcriptional regulatory pathway genes suggested to be important in talipes equinovarus pathogenesis 134701 5307 9496 1105 PMC3601265__F2 Hypothetical pathways involved in MHC–self peptide-TCR recognition and PNH clone dominance 7054 3600 3574 3558 3586 7124 PMC3601410__F1 Nrf2 is bound to Keap1 in the cytoplasm 9817 1728 4094 PMC3606489__F3 TGFB/BMP and the Wnt pathway 4092 4089 1499 PMC3606533__F1 Genes in choline/1-carbon metabolism and related pathways influence hepatic lipid balance 4524 23446 55349 635 10400 80339 5244 324 PMC3607163__F2 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential 1499 23002 387 PMC3607745__F2 Cytokine and downstream signalling pathways in liver ischaemia reperfusion injury 3627 7099 3579 367 920 6775 PMC3612991__F2 Harmonies Played by TGFB in Stem Cell Biology 3976 4089 79923 6657 4838 2932 1499 9241 PMC3614012__F2 IGF-1R and EGFR/HER2crosstalk occurs by two main mechanisms 3479 3481 1956 3480 PMC3616974__F6 Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB 10301 3839 283518 220107 257397 PMC3617288__F8 Model for the new PLD2-Fes-Jak3 pathway 5091 2242 5338 3718 PMC3618452__F3 Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats 875 3064 1119 4117 3075 2742 2395 PMC3621569__F6 Planar cell polarity pathway (PCP pathway, non-canonical pathway) cascade 7474 7481 57216 9620 23002 387 PMC3621754__F6 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches 6772 6774 4582 8717 7186 5970 PMC3627353__F2 Genes and signaling pathways involved in ureteric budding 652 2296 2303 2668 6092 5979 9353 2625 6299 2138 6495 5076 PMC3627353__F3 Genes and signaling pathways involved in ureter development 57657 6608 6469 3815 1499 9096 652 57616 1739 185 PMC3628764__F1 Alternate routes of endocytic traffic of activated tyrosine kinase coupled cell surface receptors and the role of Cbl-family protein dependent ubiquitination 1950 867 1956 PMC3630382__F7 Ingenity Pathway Analysis (IPA) from genes with loss of heterozygosity and somatic mutation (sample G05) 29079 10301 220107 3839 5925 7417 23139 2862 2624 3356 10206 57105 27239 84636 83551 317701 10161 PMC3630382__F8 "Cancer, Hematological Disease, Cell Cycle" Network 84432 6195 3645 58157 23139 7093 8804 4869 2688 4332 2624 7732 1050 63940 6434 51705 29855 5885 907 PMC3631463__F8 Combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation 7099 7096 4615 25827 26273 7186 7189 PMC3632385__F2 Schematic overview of estradiol-mediated genomic signaling pathway via ERA/B and rapid nongenomic signaling pathways via GPER, Gq-mER, and membrane subpopulation mERA/B 1950 1956 6714 PMC3637405__F2 Regulation of the p53-MDM2-MDMX pathway by DUBs 7874 7375 55611 4193 84132 57663 9100 PMC3640439__F1 Induction and evasion of type I interferon responses by influenza viruses 51311 7098 51284 4615 3661 57506 PMC3640986__F2 Steroid Receptor Coactivator-3 as a Potential Molecular Target for Cancer Therapy 4282 3667 8660 3479 3480 3553 PMC3648215__F1 Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis 999 1499 387 367 51176 PMC3648340__F1 Iron and Diabetes Risk 9843 3077 7018 148738 7036 2242 PMC3649103__F2 Hepatic ethanol metabolism 3667 471 355 4023 7038 PMC3650722__F3 Network was generated using Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com) 80310 22808 3988 345 6272 PMC3652335__F2 Lin28: Primal Regulator of Growth and Metabolism in Stem Cells 6657 79923 6929 79670 23318 79727 389421 4609 3481 3159 8091 PMC3652659__F3 Marginal zone B cells: virtues of innatelike antibody-producing lymphocytes 3458 643 10563 929 958 2638 920 7054 PMC3657461__F5 ERK and PI3K activation and their crosstalk 2885 5728 3265 572 3725 PMC3657472__F1 Genetic predisposition to peripheral nerve neoplasia: Diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes 960 5979 6598 PMC3658451__F2 Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity 64127 64170 10892 8915 7096 7097 51311 10333 7100 54106 7099 7098 51284 PMC3662029__F4 Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses 3458 1977 9636 PMC3663533__F8 The regulation of TLR signaling by Lgr4 929 7097 7099 4040 4041 114609 4615 1499 7189 PMC3665263__F2 Innate immune system in pneumococcal meningitis infection 7097 7099 54106 4615 51135 114548 9447 7189 PMC3666170__F3 Role of Cx43 and Panx1 hemichannels in paracrine signaling in taste transduction 5330 29850 24145 PMC3668835__F4 Genomic landscape of small intestine neuroendocrine tumors 2322 2263 2064 5290 6714 207 208 2475 PMC3674397__F2 Mechanisms of activity for sirtuins in Alzheimer's disease 351 6093 102 5915 PMC3677135__F7 Wnt signaling pathways 4041 4040 6259 5754 324 2932 6010 1499 PMC3677579__F2 Accessory molecules for Toll-like receptors and their function 7096 7097 7099 81622 54106 51284 7098 PMC3679471__F6 MSP-RON signaling pathway 7099 7097 6347 729230 3458 3717 PMC3680934__F1 Activation of TAZ upon epithelial-to-mesenchymal transition in human breast cancer cells 4771 4485 9113 26524 960 PMC3682211__F7 Aspirin targets multiple components of the AMPK/mTOR signaling pathway in colorectal cancer 7249 7248 2475 PMC3683810__F8 Proposed model of p38 MAPK regulation of mRNA translation 3553 29904 50846 1977 1938 1984 PMC3684061__F4 Genetic Risk Factors for Pancreatic Disorders 9075 5644 6690 11330 1080 846 PMC3684860__F7 Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish 5015 10002 1406 7068 6096 4901 2780 2779 2978 PMC3690158__F1 Wnt signaling pathways 6259 6714 1499 PMC3693579__F5 Signal transduction in MMTV-Pax8PPARG mice 5728 2932 1499 100133941 PMC3695748__F6 Schema of regulatory mechanisms of endothelial atherosusceptibility discussed in the text 406947 3383 7412 9314 10365 406991 PMC3699383__F1 Apoptosis pathways 8772 637 581 331 572 PMC3703549__F8 Ang II activates the Notch1/Snail signaling, which is responsible for the pathogenesis of proteinuria in diabetic nephropathy 367 4851 3280 PMC3707895__F6 NGF-Induced Cell Differentiation and Gene Activation Is Mediated by Integrative Nuclear FGFR1 Signaling (INFS) 4803 2260 2247 1641 7054 PMC3711318__F10 Proposed model for activation of the ATR/Chk1 signaling pathway and G2/M phase cell cycle arrest induced by HNE 891 983 995 PMC3712008__F3 Hypothetical representation of opposite downstream effects of two signaling pathways on the G1 phase of the cell cycle in a breast tumor-initiating cell 2260 2064 3480 3725 4214 6416 5728 5925 2625 595 80139 1021 1019 1017 1028 1031 1032 PMC3712086__F5 Diagram illustrating the signaling mechanism of how CARD9 may be inhibiting apoptosis from TNF-alpha 8717 8772 7186 64170 PMC3713213__F7 Signaling pathways showing mechanisms involved in the protective effects of cardiac-specific CYP2J2 transgenic mice subjected to diabetic stress 1573 545 3667 5166 PMC3714203__F2 DR4 and DR5 Agonistic mAb-induced Apoptosis: Regulation of TRAIL/Apo2L Resistance by HDACi 572 638 637 56616 331 PMC3717758__F3 Structure–activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease 351 348 23163 26088 PMC3718996__F8 Graphs showing the different regulation of glioma cell signaling when cells were cultured on biomatrix, myelin and unmyelinated tissue (retina) 387 9475 3985 3984 PMC3721286__F3 Simplified scheme presenting multiple feedback loops in the EGFR pathway 1956 2885 2002 6722 23764 7538 4609 2353 3725 1958 26018 PMC3721632__F1 Th17 cell based vaccines in mucosal immunity 613 2919 5284 10563 3458 50616 149233 3553 6373 3627 4283 PMC3723114__F1 Canonical and noncanonical TGFB signaling systems activated during mammary tumorigenesis 4015 4088 4087 2885 4089 387 PMC3723562__F7 Polyethyleneimine Mediated DNA Transfection in Schistosome Parasites and Regulation of the WNT Signaling Pathway by a Dominant-Negative SmMef2 9734 9759 7471 7472 PMC3724248__F1 MicroRNA pathway is universal to all mammalian miRNAs 29102 54487 5901 27161 PMC3727840__F2 TGFB in bone metastasis: novel therapeutic perspectives 100187907 4089 4087 4088 387 998 PMC3729625__F3 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling 2539 57103 2597 9140 PMC3730324__F1 HIFs are involved in crucial aspects of tumor progression and metastasis in sarcomas 7428 3481 8788 5243 PMC3730813__F2 Pattern Recognition Receptors in Intestinal Inflammation 7099 7098 7100 4615 10392 64127 7189 3661 PMC3732459__F3 Innate Immune Responses in Hepatitis C Virus Infection 11274 9021 3276 7297 3454 3455 3716 PMC3733450__F2 Kaposi’s Sarcoma-Associated Herpesvirus G Protein Coupled Receptor: Lessons on Dysregulated Angiogenesis from a Viral Oncogene 5728 6794 51422 7249 7248 6009 2475 7428 1977 PMC3735949__F4 Comparison of the gene expression and eicosanoid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the arachidonic acid metabolism pathway 5322 5321 240 8398 100137049 5742 5743 5730 9536 1506 PMC3737722__F7 Model of cell-surface regulation of HH signaling 2619 5727 50937 6608 91653 8643 PMC3737723__F8 Model of the Prdm1a gene regulatory network for NCC specification 2896 256933 7020 27022 6663 PMC3742659__F2 Learning and memory: an emergent property of cell motility 1950 10371 1956 2475 5728 387 PMC3743959__F1 Toll-Like Receptor (TLR)-Associated Sequence Variants and Prostate Cancer Risk among Men of African Descent 4018 929 7124 695 51135 7189 11213 54472 3656 836 4790 7097 10333 114609 4615 PMC3744053__F5 Signaling pathways of anti-permeability factors 7422 1003 6714 PMC3745713__F2 Methionine–homocysteine and aromatase pathways and their involvement in 2-ME synthesis 5212 4552 4548 1312 4524 PMC3746754__F2 Iron metabolism in the eye, a review 5093 3077 7036 1356 PMC3748257__F2 STAT signaling in mammary gland differentiation, cell survival and tumorigenesis 4582 6772 6778 PMC3749870__F10 CD25 and CD69 induction by A4B1 outside-in signalling requires TCR early signalling complex proteins 969 3932 27040 7409 PMC3751776__F2 BTK signaling pathway 6850 4067 29760 6774 PMC3753040__F1 Chromatin Recruitment of DNA repair proteins: Lessons from the Fanconi Anemia and Double Strand Break Repair Pathways 2175 2187 55215 2188 2178 2176 2177 2189 55120 57697 545 672 7398 675 PMC3757391__F1 Maintainance of DNA Methylation 1789 8930 1786 6996 80312 8772 1788 545 472 PMC3757395__F1 Scheme of miRNA processing pathway 22937 100187761 29102 PMC3757426__F1 Epidermal growth factor receptor (EGFR) crosstalk 1956 2064 2066 2065 6714 3480 PMC3759173__F4a Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy 2157 633 1363 1438 9404 1513 122953 8470 3398 3428 PMC3759561__F1 Regulation of Muscle Protein Synthesis and the Effects of Catabolic States 3479 7249 7248 2932 PMC3760419__F4 Cell Death in Disease: Mechanisms and Emerging Therapeutic Concepts 7124 355 581 8772 637 7939 PMC3760732__F8 Pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways 3082 3280 5728 PMC3763042__F1 Working model of renoprotective pathways activated by relaxin 59350 4842 4087 4846 4843 PMC3764474__F1 SIRT1-dependent deacetylation of substrate proteins 64802 349565 23057 10135 23411 PMC3764828__F5 Model depicting mitochondrial generation of H2O2 as a key modulator of TCR-mediated signal transduction 324 920 27040 5335 2885 3932 7535 PMC3770684__F3 SNP (–617C>A) in ARE-Like Loci of the NRF2 Gene: A New Biomarker for Prognosis of Lung Adenocarcinoma in Japanese Non-Smoking Women 9817 4193 4094 9429 PMC3772104__F2 Involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis 3717 3716 6369 10344 29949 PMC3772117__F2 Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway 474168 9055 1445 PMC3773820__F8 Role of Nor-1 in incretin-induced insulin expression and secretion and hypothetical localization of the TCF7L2 and NR4A3 SNP effects 8013 6934 3630 PMC3775402__F1 Alternative splicing regulation of the Ras-MAPK pathway 2872 1977 6426 PMC3775402__F2 Alternative splicing regulation of the PI3K-mTOR pathway 5728 7249 6009 6426 2475 1977 PMC3775648__F2 Major elements of the noncanonical PCP Wnt signaling pathway 7474 54361 7481 81029 57216 81839 4919 1952 1951 8323 4920 166336 144165 22881 1855 5879 23002 23500 6885 4215 4216 4214 10746 9064 387 4296 4293 1326 4294 7786 9175 9020 9475 5609 6416 5601 5602 5599 PMC3776238__F2 Wnt regulation of larval NMJ differentiation 2535 474168 1810 PMC3779382__F2 EBV-mediated oncogenic signaling pathway activation in EBV-positive diffuse large B-cell lymphoma of the elderly 7185 7186 7188 7187 8717 1017 PMC3779571__F1 Chondrocyte gene network of CSGalNAcT-1 was classified as glycan biosynthesis and metabolism and functional pathway 10090 54741 5970 4247 79586 PMC3782519__F1 MicroRNAs as novel immunotherapeutics 1950 1956 6464 7297 6774 5594 5595 10401 PMC3783495__F7 Antagonism of Betulinic Acid on LPS-Mediated Inhibition of ABCA1 and Cholesterol Efflux through Inhibiting Nuclear Factor-kappaB Signaling Pathway and miR-33 Expression 7099 4615 19 PMC3783819__F2 Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction 2885 2475 4827 4286 3725 2353 6722 2002 PMC3783819__F3 Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction 3082 3479 1950 3480 1956 2885 9846 4087 6774 5970 4827 595 960 4609 4313 2919 1499 PMC3785965__F4 p120catenin regulation of Rho-GTPase signalling 7410 387 998 PMC3787240__F2 Selected non-epigenetic effects of sulforaphane and I3C/DIM on prostate cancer cells 5728 2475 2810 581 1021 367 596 PMC3788325__F2 Signaling pathways in RILF 2932 387 2305 999 1499 PMC3788606__F3 TGFB signaling 7048 7046 6010 6497 PMC3789860__F3 Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure 627 387 7204 PMC3792444__F1 Induction of migratory heterogeneity during priming 7430 960 643 2638 942 940 941 10365 958 2308 1236 3458 2833 604 PMC3794709__F1 Steps in the reverse cholesterol transport pathway 4023 5360 1071 3949 3931 19 9619 PMC3795238__F8 A model depicting androgen-AR-miR-29a regulation loop 367 3479 998 407021 PMC3797199__F1 Aryl Hydrocarbon Receptor Promotes RORGt+ ILCs and Controls Intestinal Immunity and Inflammation 196 4055 3553 3815 4853 PMC3797768__F4 An Integrated Approach Based on Multiplexed Protein Array and iTRAQ Labeling for In-Depth Identification of Pathways Associated to IVF Outcome 1401 57817 2243 183 3929 325 5340 3565 350 5054 7054 4153 710 7018 3273 PMC3798724__F2 Wnt signaling pathway in the primary cilia 7976 57216 324 1499 PMC3800061__F2 Basic NOD2/RIP2 pathway of NFKB activation 64127 331 7186 7189 7188 23118 257397 PMC3807004__F2 Mitochondrial biogenesis by HLA20 involves activation of the Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha (PGC-1A) pathway 7019 25886 8205 PMC3808429__F7 Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology 2064 1499 1956 3320 6464 6714 3716 5335 6774 3091 7422 PMC3808753__F1 Coordinated action of glial and neuronal purinergic receptors and purines in the CNS 84890 3976 627 PMC3808934__F2 Interplay of TLR and RLR signaling 7099 7098 51311 51284 54106 4615 7187 7189 29110 3661 3665 PMC3810143__F9 Downregulation of Nuclear-Encoded Genes of Oxidative Metabolism in Dialyzed Chronic Kidney Disease Patients 7019 4899 7528 PMC3814228__F1 Schematic diagram of the adiponectin-AMPK pathway in glomerular cells 51094 79602 4280 50507 7391 PMC3814821__F8 Proposed mechanism for the CD8+-cell-mediated suppression of HIV-1 replication 939 1236 920 3455 6041 6035 3454 PMC3816993__F2 Combined miRNAs and transcription factor regulation of inflammation in wound healing 1649 4790 1385 3659 2113 407046 1387 4908 406938 3654 6347 3586 3725 7124 54106 7189 406947 406885 3569 5966 6667 355 6670 406991 213 2353 51284 857 1869 7099 406915 7046 PMC3817742__F7 ABCB10 and heme synthesis pathway 211 212 23456 PMC3818842__F6 Major apoptotic pathways in SGNs induced by oubain treatment 7124 8772 637 581 PMC3818893__F6 Hypothetical role of the AhR pathway in the development of inflammatory bowel disease after exposure to environmental PAH 5053 196 3553 PMC3820238__F1 Schematic overview of TGFB signaling 4838 4092 6010 4087 4091 3984 7018 PMC3822721__F3 FHL1 isoform KyoT2 and Notch signaling 6015 8554 4855 4853 4851 4854 PMC3823115__F3 Potential mechanism of the HGF/ c-Met signal pathway hallmarks in lung cancer 3082 1956 2475 207 PMC3824101__F1 Mechanisms involved in type I IFN production and its receptor signaling 3716 7297 355 6772 6773 7098 4615 29110 10379 115004 3661 3665 9208 57506 54106 51284 10392 64127 7099 51311 PMC3827841__F6 TGFB and NOTCH activation in AoSMCs stimulated with P 7939 4087 4088 4092 4089 3280 PMC3835153__F2 Cisplatin resistance.Notes: Cisplatin creates DNA adducts and activates the apoptotic pathway, thus killing rapidly dividing cells 2064 540 538 836 PMC3836362__F6 Interaction between dietary protein and mechanical loading on skeletal muscle cell 2475 1938 6194 PMC3837441__F7 The Cdc42-dependent regulation of neural differentiation in P19 cells 2475 998 388585 5080 PMC3837458__F1 Triacylglycerol synthesis and acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes 8694 84649 95 PMC3840254__F8 Summary of proposed pathway leading from TGFB1 receptor binding to ROS generation 7249 50507 7351 23411 2475 6098 PMC3841210__F7 FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer 1637 8772 637 56616 581 2309 1499 864 PMC3842494__F8 The proposed role of high CORT levels on the proinflammatory response triggered by LPS and related to MAP kinase–NFKB pathway in rat brain 7099 2638 3553 3603 PMC3843239__F7 Mechanism of myosin II–mediated release of microparticles from endothelial cells activated by antiB2GPI antibodies 4615 6010 3654 51135 7189 PMC3843886__F2 Schematic of common signalling pathways underlying activity-dependent and leptin-dependent synaptic plasticity 3717 6774 2932 PMC3844829__F4 Metacore™ apoptosis signaling pathway relating to caspase activation 3479 6247 637 790 PMC3845601__F2 Wnt/Beta-catenin signaling pathway 11197 50964 4040 4041 1499 324 PMC3851046__F7 Proposed molecular mechanism for the inhibitory effects of zinc on RANKL-induced osteoclastogenesis 84876 126014 10326 7189 6850 4772 PMC3852078__F6 BDNF-related PPI network 2099 7316 1993 627 1994 PMC3853754__F1 The mitochondrial life cycle 56947 55669 9927 4976 65018 PMC3854132__F1 Systems Modeling of Anti-apoptotic Pathways in Prostate Cancer: Psychological Stress Triggers a Synergism Pattern Switch in Drug Combination Therapy 1950 5728 1956 7432 4170 572 PMC3856398__F3 Ras-dependent versus Ras-independent extracellular signal-regulated kinase (ERK) signaling 27040 3932 10125 5058 PMC3861317__F3 Mechanistic Phenotypes: An Aggregative Phenotyping Strategy to Identify Disease Mechanisms Using GWAS Data 472 545 672 2175 55215 84464 2177 675 PMC3862457__F1 Signaling pathways that modulate amino acid, insulin/IGF-I, and resistance exercise–induced activation of mTORC1 signaling 7248 51256 7249 6009 64223 9681 10641 54468 81929 84219 79726 6396 PMC3863339__F1 RACK1 signaling complexes 6714 10399 581 595 PMC3864579__F1 CD4 T-cell immunotherapy for chronic viral infections and cancer 920 643 5091 958 3466 3565 324 940 613 PMC3867948__F4 Death receptors and the extrinsic pathway of apoptosis 355 8772 8717 637 PMC3871247__F6 TTC7A mutations disrupt intestinal epithelial apicobasal polarity 387 6010 57217 5728 PMC3871884__F8 Schematic diagram illustrating central role for ROS and Src in hypoxia-induced pY654-Beta-catenin/HIF1A formation and tumor EMT 1956 999 7040 1499 6714 3091 PMC3874316__F7 Antcin C-induced upregulation of antioxidative gene expression via the Nrf2/ARE signaling pathway and suppression of AAPH-induced apoptosis in human hepatic HepG2 cells 1728 581 596 9817 317 4094 PMC3874981__F5 NELL-1 signaling pathway 4745 1499 6608 324 51176 6932 4041 PMC3875462__F1 Regulation of the mTOR signaling pathway 92335 5728 7248 7249 6009 1977 PMC3876432__F3 IL-6-STAT3 signaling and premature senescence 6774 3488 4790 5970 3552 3576 PMC3876433__F1 Oxidative metabolism in cancer 6714 9846 6774 4170 5292 7424 PMC387762__F5 CREB pathway and possible positions of proteins whose genes contain CREB1 binding sites 4282 5900 23779 2885 11252 23523 PMC3878444__F2 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro 10771 6385 79931 23085 6504 11213 117854 629 10105 415116 64581 3726 3725 2745 5052 5167 7296 9589 4891 PMC3880796__F2 TRAIL on Trial: Preclinical advances for cancer therapy 637 836 56616 842 331 581 317 8772 PMC3882377__F6 Schema of our hypothesis 948 6469 6608 PMC3883963__F3 HMGB1-TLR4 signaling mediates liver I/R injury 7099 3146 929 7124 PMC3886798__F3 Overview of the treatments in the context of previous results obtained with a test system based on the fluorescent reporter protein H 6-GFP-BD-CVIL in transgenic tobacco BY-2 cells 2353 4893 3265 PMC3887674__F1 Factors influencing the reprogramming of unipotent SSCs into pluripotent stem cells 442917 79923 339345 2668 6657 2674 6875 PMC3887856__F3 SH3BP4 is a potential tumor suppressor functioning in the amino acid-mTORC1 pathway 3479 5728 23677 7249 7248 6009 PMC3887879__F3 Nutrient signaling to mTORC1 6510 6520 8140 2744 23677 8607 10856 2475 64223 6009 PMC3888473__F4 Pathway analysis on SNPs that affect gene expression and drug response 6210 1565 5467 9469 43 1576 2908 7448 6667 7157 406976 406940 57419 353189 66002 10599 3181 7124 3192 3183 9971 26998 PMC3890705__F6 Proangiogenic mechanisms activated in the omentum during transcoelomic EOC metastasis in the presence of anti-VEGF therapy 5196 3082 7422 58191 7076 4318 3490 3485 PMC3890879__F8 Model of mevalonate and Hippo pathways regulating YAP-controlled RHAMM transcription and cancer cell motility 387 4485 9113 26524 PMC3892798__F1 PD-1 in T-cell activation, exhaustion, and effector function 324 941 942 940 PMC3898353__F1 Complement activation pathways 5648 718 629 3075 1675 3426 717 1378 727 729 730 735 966 7448 PMC3901523__F3 Signaling pathways for inner ear proliferation and differentiation 4760 4762 474 3280 1032 1026 1027 PMC3903560__F7 Ingenuity pathways analysis 4214 5641 8832 80833 9603 8542 10068 6504 84868 114769 PMC3904516__F8 LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NFKB and BMP/Smad Signaling 650 7099 4615 4086 4089 860 3553 1277 PMC3904625__F8 Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation 7173 861 2313 22852 PMC3911241__F4 Examples of network refinements and reannotations 8564 8942 23498 PMC3913524__F1 The PI3K/Akt/mTOR pathway substrates and associated cellular functions 7249 6009 5728 2475 253260 1977 PMC3913902__F4 Induction of NLRP3 inflammasome complex by the inorganic crystal HZ 4067 6714 6850 10628 114548 PMC3915736__F2 Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy 324 2475 939 604 8320 639 3398 10365 PMC3918861__F2 Induction of apoptosis 355 8717 8772 581 572 637 PMC3922160__F9 Proposed model integrating viral and host biomarkers for disease severity and the effect of IFNB in HAM/TSP 930 941 920 50943 3050 5966 6772 942 PMC3923671__F1 Impairment of T Cell Function in Parasitic Infections 355 581 637 PMC3924162__F2 Signaling pathways in PCSCs 1950 6469 5727 4853 4851 6608 1499 2736 2737 2735 648 79923 6657 PMC3924811__F10 Mechanosignaling in Bone Health, Trauma and Inflammation 1499 860 1277 650 PMC3925027__F2 Cytokines and their receptors regulating peripheral B-cell survival 3082 10673 4282 613 5803 972 960 115650 6850 11040 PMC3928697__F5 Proposed pathway of CD33 siglec-mediated suppression of cellular function in Leishmania infection 945 8778 9021 3458 PMC3929000__F1 TRAIL signalling induces the extrinsic apoptotic pathway 9242 8772 637 PMC3929246__F1 Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment 4018 929 51135 3654 54472 7189 3656 3661 51284 51311 54106 4615 7100 114609 7096 7097 10333 7099 7098 PMC3929252__F1 Estrogen, HER2 signalling, and the PI3K/Akt pathway in drug-resistant breast cancer.Notes: ER can activate gene transcription by nuclear translocatin following ligand binding (1) or as a result of receptor phosphorylation in the absence of ligand (2) 3480 6714 572 2932 5728 PMC3930365__F6 Second ranked network of genes altered in the newborn lung at 24h post-O3 exposure 55839 7216 126549 705 1611 51280 150356 405 2874 157570 9735 55010 55055 55320 9183 9631 64105 PMC3931394__F2 Transcriptomic analysis of isolated islets from GLU+IL–infused 6-month-old rats 1839 7351 5347 PMC3931462__F8 Proteolytic cleavage of CDCP1 contributes to enhanced tumor cell survival and motility through the FAK and Akt signaling pathways downstream of complex formation between cleaved CDCP1 and B1 integrin 64866 5340 6714 PMC3932023__F2 Exosome secretion in a cancer cell model 5873 5874 84932 9367 5868 5872 PMC3932427__F1 Schematic showing the interference of Hepatitis C virus in the insulin signaling pathway 9021 2475 6009 7249 7248 PMC3932947__F7 En2 modulates IGF1’s pleiotropic effects in GNPs, potentially through altered S6 kinase activation 3479 3480 5163 2020 PMC3934462__F1 Apoptosis signaling and cell death relevant drugs 8717 8772 581 637 317 PMC3935732__F4 Role of ABL Family Kinases in Cancer: from Leukemia to Solid Tumors 7852 6714 1399 6774 4312 PMC3936609__F6 Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment 637 581 2002 PMC3936782__F2 Neuroprotective/apoptotic intracellular cascades at baseline and as mitigated by mood stabilizers in BD 627 790 317 637 572 581 PMC3937043__F5 Ingenuity Pathway Analysis (IPA) of the 39 differentially expressed genes in MFG transcriptome at 18 hpi vs 7538 5265 1522 3553 597 1958 1647 PMC3937510__F2 Canonical Wnt signaling () 2487 22943 4041 4040 324 PMC3938021__F3 Dissecting the Molecular Basis of the Role of the O-Mannosylation Pathway in Disease: Alpha-Dystroglycan and Forms of Muscular Dystrophy 8704 55624 148789 PMC3944322__F1 Parkinson's Disease Gene Therapy: Success by Design Meets Failure by Efficacy 4902 2668 7054 PMC3944966__F1 p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock 5053 2023 100682260 3081 2184 PMC3945866__F6 In addition to the known pathways that activate hepcidin expression, we show that Ras/RAF-triggered signals and the mTOR pathway are involved in hepcidin suppression 2475 3569 7528 2353 6722 1387 PMC3946772__F1 Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes 4018 80339 50486 4099 PMC3947622__F1 Molecular programming of B cell memory 2638 613 920 PMC3947785__F1 What’s the Mtrr with your grandparents? 4552 2147 2152 4524 4548 PMC3951857__F1 Wnt/Beta-catenin signaling pathway 50964 4041 324 PMC3952558__F2 TLR4 Signaling Pathway 929 4615 3663 3661 7099 114609 PMC3955095__F2 Targeting the Bcl-2 Family for Cancer Therapy 572 637 581 56616 PMC3956533__F7 Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells 7249 7248 1975 27250 PMC3956809__F4 Tissue-specific expression within individual functions—a case of insulin signaling pathway 10664 391 5584 5471 2191 808 3265 8789 2319 5563 5260 5565 5792 23433 2475 2194 90673 PMC3960869__F2 Interaction of Neisserial surface molecules with the complement system 717 4827 718 727 735 730 729 PMC3961361__F8 MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection 57506 3661 7187 8717 1540 7189 PMC3961774__F5 Role of Heme Oxygenase-1 in Postnatal Differentiation of Stem Cells: A Possible Cross-Talk with MicroRNAs 9242 1499 650 860 6662 4772 468 339834 PMC3962044__F1 NFKB signaling pathways in osteoclast lineage cells 7189 7187 7186 23118 257397 5971 PMC3963078__F7 HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors 207 10000 208 10682 PMC3965270__F8 Integration of L-R Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2 4838 5308 7474 2719 23500 1000 PMC3972679__F1 The two pathways of apoptosis 581 8772 637 PMC3975402__F2 Apoptosis pathway 8772 572 581 637 317 PMC3976614__F1 Modulation of mitochondrial dysfunction by the PINK1/PARKIN pathway 65018 9927 7416 PMC3976829__F4 Schematic illustrations for potential signaling pathway of IMF deposition in skeletal muscles regulated by GHR and SOCS3 2690 9021 3953 4023 208 80326 4088 10643 PMC3977149__F1 p53 effects multiple areas of cellular metabolism 57103 9997 27165 PMC3980848__F1 MicroRNA Regulation of T Helper Cell Differentiation and Plasticity 1848 1847 7189 26191 8651 2475 29102 7008 54487 5728 27161 3458 3560 639 2308 PMC3981572__F9 Integrative model of the physiogenomic adaptations in adipose and liver tissue induced by energy overfeeding during the last 45 days of pregnancy 51 9612 54677 1384 37 5465 6256 215 1431 3158 6095 26291 51129 338 123 8835 4547 2690 3479 3483 23417 31 8694 PMC3982501__F4 Receptor tyrosine kinase (RTK) signaling pathway is frequently hit by lentiviral vector (LV) integration 2885 673 5921 1326 5728 4193 2475 PMC3983408__F7 Mechanism of immune dysfunction in Huntington’s disease 51135 3569 3654 100187907 PMC3996583__F2 Construction of the FB-iPSC-CM regulatory circuit 100653366 79923 3976 6657 1356 3670 134701 9314 64319 2626 6910 4208 PMC3997714__F1 Autophagy is involved in the initiation of hepatocarcinoma (HCC) 2475 83939 619501 PMC3999155__F6 HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1 57506 7187 55611 29110 3661 PMC4000463__F1 JAK2 receptor signaling and activation of STAT pathway 2056 4352 3717 6774 PMC4002295__F1 Schematic presentation of the rationale of targeting PARPs for cancer therapy 6741 672 675 PMC4002948__F7 Possible molecular mechanisms by which Alpha-TOS overcomes the resistance of erbB2-expressing cells to apoptosis and sensitizes them to hrTRAIL-induced apoptosis 2064 718 735 PMC4007467__F11 Proposed integrin signaling switch model 857 2534 6714 PMC4008387__F2 Molecular mechanisms of hepcidin regulation 2056 5045 164656 9518 654 148738 7036 4090 4086 6774 4089 57817 PMC4012776__F1 Trim21 negatively regulates the DDX41-mediated signaling pathway 51428 6737 29110 3661 3665 PMC4013413__F2 Roles of ALK in the pathogenesis of ALK+ anaplastic large cell lymphoma (ALCL) 6714 3667 3718 3726 6774 2885 2475 4170 572 238 23557 PMC4013649__F7 A20 on LPS signaling pathway 7099 51135 3654 7189 958 PMC4015472__F2 Post-Transcriptional Regulation of Interferons and Their Signaling Pathways 7099 51284 3716 7297 4615 100616245 51135 3654 3454 7189 23118 100302158 10454 3661 3665 4625 57644 PMC4016161__F1 The succinate dehydrogenase complex (SDH), as a member of the tricarboxylic acid cycle (TCA), catalyzes the oxidation of succinate to fumarate 6392 6391 6389 2242 6390 PMC4016833__F1 Signaling events in murine heart development and cardiac ESC differentiation 6910 90525 3670 4838 PMC4016892__F6 Schematic model illustrating the signaling pathway by which ANG suppresses the inflammatory response involving TBK1-mediated NFKB nuclear translocation in HCFs inflamed by TNFA 3606 3586 3565 PMC4017424__F1 NFKB signaling pathways 7124 8772 6955 100187907 PMC4017675__F5 In sum, there is a critical clinical need for better understanding and treatment of inflammatory airway disease in general, and mucous cell metaplasia in particular 6778 4586 727897 283463 PMC4019040__F1 Mutated and wild-type tyrosine kinase activation in cancer 1956 4067 6850 695 2064 2247 2260 613 PMC4020998__F1 Apigenin Modulates Insulin-like Growth Factor Axis: Implications for Prevention and Therapy of Prostate Cancer 3486 3667 126669 6256 PMC4021255__F3 Ingenuity Pathway Analysis of genes negatively regulated by unliganded GR 4969 6610 7067 9049 6387 117581 114898 1942 4320 23187 6480 598 5054 871 3694 1848 55959 6678 5334 PMC4021255__F4 Ingenuity Pathway Analysis of genes positively regulated by unliganded GR 718 3398 5618 57379 6777 6776 5698 894 7114 9168 8638 2908 5031 81035 10379 1356 9023 972 6672 1777 11274 64108 PMC4023029__F7 Proposed pathway for activation/proliferation of alloantigen-specific nTreg and comparison with the non-antigen driven proliferation of nTreg that do not have a TCR specific for the antigen 3595 920 50943 3568 PMC4026397__F2 Role of NADPH Oxidases in Liver Fibrosis 1636 27035 10811 5728 PMC4026919__F1 Wnt signaling pathway 324 1499 2932 4286 2254 6010 6259 PMC4029773__F1 JAK-STAT signaling in adipose tissue function 4280 5617 355 5166 PMC4031942__F13 Anti-inflammatory mechanism of C3G is associated with upregulation of the LXRAlpha-ABCG1 pathway which results in disrupting lipid rafts by depleting cholesterol, thereby suppressing the TLR4-mediated NFKB and IRF3 signaling pathways induced by LPS 9619 4615 7099 3661 PMC4033420__F1 Colorectal cancer MSI and CIN signaling pathways modified from KEGG database 324 1499 387569 3845 5900 836 842 1630 7046 4087 4088 4089 581 596 PMC4033628__F2 Synthesis of representative structures along the Golgi-centric core M1 and M2 glycan synthesis pathways 29954 10585 84892 55624 2592 27087 10690 PMC4034727__F1 LncRNAs associated with the p53 pathway 378938 4193 55384 55135 283120 PMC4036091__F2 Schematic diagram representing the hypothetical mechanisms of the insulin-dependent systemic (I) and insulin-independent direct (II) effects of metformin in the endometrium 3480 3667 5728 7249 7248 2475 PMC4036111__F3 Schematic of the FGFR signaling pathway 2247 2260 10818 PMC4038542__F1 Complement activation and effector functions 721 727 730 729 735 PMC4040351__F4 From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling 5728 2475 182 3280 1499 2932 PMC4040598__F5 Model depicting effect of ADAM17 variant on the canonical TGFB signaling pathway 6868 4087 4089 PMC4040894__F2 Heme biosynthesis 23456 2235 5498 1371 54977 10058 210 3145 7390 7389 PMC4040907__F6 The impact of 5q deletion upon myeloid cell fate 1050 1958 4665 10949 3394 2624 1959 PMC4041713__F2 Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis 5595 657 392255 4089 659 57154 3458 4092 7057 6667 7048 4087 1875 5934 9765 7044 PMC4041713__F4 Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis 166336 387 81839 5663 8324 51701 5613 2033 1499 80319 4089 324 4088 5520 8945 6477 5332 4773 5578 PMC4044299__F4 TG2-mediated adhesion/signaling at the cell surface 6714 1499 207 387 PMC4046186__F1 Intrinsic and extrinsic apoptosis signaling pathways (adapted from ref 8717 8772 835 841 54205 317 842 836 839 840 PMC4046345__F2 dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects 57506 7186 331 7189 29110 7187 581 3661 10013 PMC4046911__F2 PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis 39 131566 4783 3399 4092 4616 2059 154 26471 PMC4051248__F9 LPS up-regulates the PhT2 signaling pathway 929 7099 4615 114609 PMC4052840__F2 Therapeutics in development that target survival pathways activated by LMP1 and LMP2a 2534 6850 2475 PMC4055201__F8 Schematic diagram illustrating the possible mechanisms responsible for CORM-2 effects on LPS-induced VCAM-1 expression in RASFs 4615 7189 7412 2353 3725 PMC4057083__F8 On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio 1236 2833 2260 2263 4804 2261 5159 55558 1129 7852 3718 3717 2885 5062 PMC4057133__F6 Summary of signaling events leading to PRKD2-dependent induction of senescence in p53wt and p53mut GBM cells 25865 1019 1017 595 1869 PMC4057789__F1 Cross-talk between EpCAM signaling and the Wnt pathway 2274 2932 324 1499 79923 6657 4609 4072 PMC4061845__F2 Sphingolipid involvement in ethanol-induced apoptosis in the P7 mouse brain 1901 2932 56848 581 PMC4062953__F2 Classical and non-classical pathways of androgen biosynthesis 1583 412 6820 1586 3293 8644 3294 1588 6715 1646 8630 3028 1645 5959 1733 7364 9420 7366 7367 PMC4063840__F2 In vivo gut transcriptome responses to Lactobacillus rhamnosus GG and Lactobacillus acidophilus in neonatal gnotobiotic piglets 7124 4117 3146 PMC4064721__F1 Scheme of participation of MC1R in regulation of melanogenesis 434 56246 4157 23295 156 2870 408 409 4286 PMC4064721__F2 Scheme of the impact of MC1R on development of melanoma 6383 4157 4893 6714 673 4286 PMC4065342__F2 The biosynthesis pathway of the major terpenoids in plants 4200 4155 3652 10993 PMC4067122__F6 Schematic drawing of the Hippo pathway in human EC 407035 26524 10413 595 PMC4069674__F1 Suppression of metastasis by mirtazapine via restoration of the Lin-7C/Beta-catenin pathway in human cancer cells 1499 8573 320 3358 55327 1742 1741 PMC4070062__F3 Cytosolic nucleic acids sensors and autophagy 115004 80712 3661 PMC4070521__F1 Biosynthetic pathway of n3 and n6 PUFAs highlighting a set of genes known to play key roles in the biosynthesis and metabolism of LC-PUFAs in two parallel and competing pathways 9415 2717 3992 95 PMC4073609__F2 By activating Sirt1, NAD+ conjoins two feedback loops necessary for cross-talk between the circadian clock and metabolite production 9575 64802 23057 349565 10135 23411 406 PMC4077897__F1 Emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections 50863 10013 1080 7939 22863 55626 8678 7052 5266 30849 8878 PMC4080180__F12 Current understanding of LPA/LPA5R stimulation of NHE3 activity and mobility based on current studies and the previous reports from the laboratory of Yun and colleagues (, ) 6010 1956 4018 9351 PMC4080186__F1 Rho GTPase signaling pathway represents a convergent approach to targeting fibrosis 4018 6010 6722 PMC4085491__F1 ELF4 in type I IFN signaling 57506 2000 29110 3661 3665 PMC4086377__F1 TGFB Signaling in Wound Epithelialization 7040 7046 4092 4087 4088 4089 4091 PMC4086823__F3 Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage 581 331 836 842 PMC4087127__F2 Scheme of ErbB dimers related MAPK and PI3K pathway activation 3273 1950 2065 2064 5163 2475 6194 PMC4087737__F1 A: The heme biosynthetic pathway 2242 65057 210 PMC4088925__F3 Summary of expression patterns of complement components in the placenta 1401 718 2271 1356 1378 966 735 PMC4090390__F2 Metabolic fluxes, NLRP3 and IL-1B 7099 114548 3375 PMC4092039__F2 G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin 6010 9113 26524 PMC4096053__F2 Many functions of promyelocytic leukemia nuclear bodies and PML as a negative regulator of the PI3-kinase/Akt/mTOR pathway 5371 5728 6009 7248 2475 7249 PMC4097023__F6 Working model of apigenin-induced DNA damage 571 2237 7516 5429 5810 1870 472 4609 993 3014 PMC409892__F2 Apoptotic and antiapoptotic signaling pathways 472 4193 5728 572 PMC4101819__F1 Key signaling pathways involved in genetic methylation of lymphoid malignancies 324 2932 1499 4193 PMC4101832__F2 Processes and outcomes involving leptin, OB-R, Notch1, Notch4, IL-1R tI, JAG1, DLL4, VEGF, VEGFR2 (KDR), EGFR, AR and Ki67 (MKi67 gene) in the development of breast neoplasms 7423 3952 7422 7424 54567 182 367 4288 PMC4102070__F2 Signal integration following BCR engagement 2885 29760 25780 695 102724566 10892 5336 4067 PMC4102070__F4 Points of inhibition for ibrutinib, idelalisib, fostamatinib, and Lck-i in the BCR signaling pathway 695 29760 3932 4067 5336 PMC4102943__F6 The proposed point at which dFdC metabolism interacts with the Kennedy pathway that converts choline to phosphatidylcholine, resulting in formation of GdPC, and the impact of linoleate on that reaction 907 1633 978 PMC4105198__F8 B3 integrin-KRAS-RalB complex drives tumor stemness and resistance to EGFR inhibition 1956 3845 5899 29110 PMC4106657__F4 Cancer driver genes and pathways 596 387 1387 3845 5728 4952 8471 4914 4916 10782 25970 673 PMC4106758__F6 Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A 2736 2735 4851 2247 6469 2737 3479 7422 56924 10763 5629 6657 PMC4107319__F8 GIV/Girdin is a central hub for pro-fibrogenic signalling networks during liver fibrosis 7099 4088 4087 2308 PMC4107983__F1 Transcriptional programs controlling endocytosis 1956 7157 7942 3091 PMC4108799__F3 HMGB1 binding to receptors and activating signal transduction pathway 3146 4049 6387 7097 7099 114609 7852 4615 54106 PMC4111852__F3 PI3K pathway in different breast cancer subtypes 7097 7099 5728 PMC4113827__F2 TLR4 signaling pathway 929 7099 3929 3654 7189 51135 PMC4115279__F1 Death-Defining Immune Responses After Apoptosis 581 8772 2021 317 637 790 PMC4117634__F9 Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1 7097 10333 695 4118 4615 9817 PMC4118716__F4 M1 and M2 macrophage polarization 6361 3553 6362 6367 3627 6347 PMC4120074__F7 Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor 3084 2064 2065 673 PMC4122293__F8 Fibronectin Stimulates Endothelin-1 Synthesis in Rat Hepatic Myofibroblasts via a Src/ERK Regulated Signaling Pathway 387 6714 2885 PMC4123081__F4 Ingenuity Pathway Analysis of the miRNAs identified as involved in regulation of cardiomyocyte apoptosis (see ) 405753 92304 9609 10761 57572 8821 3458 220963 3645 56262 6707 114881 56649 23411 9068 3479 117145 51393 23201 696 10887 100132074 80031 2528 117283 50856 27283 7083 80146 173 1363 100313892 PMC4127876__F1 Diagram depicting hypothetical mechanisms by which the polycystins directly affect gene transcription and regulate the cell cycle 3717 6772 1499 3398 1017 PMC4130217__F4 Protomural role of tumor-associated macrophages (TAM) 8205 1499 1950 4282 6362 PMC4131183__F3 TRAIL-induced apoptosis 8772 8567 581 637 331 9191 PMC4133945__F1 Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention 22943 1499 2932 324 PMC4133953__F9 Network for miRNAs involved in migration and invasion of cervical cancer cells 5340 494324 6667 27250 4087 387 51809 406988 10507 PMC4135953__F9 Network of genes in mice immunized with UV-V after SARS-CoV challenge 342510 9388 10010 7098 6289 3665 629 5806 4615 4323 133 3624 7127 5327 6590 54106 9641 PMC4136419__F2 Targeting the B cell receptor signaling pathway in B lymphoid malignancies 3574 4067 695 6850 29760 60468 5897 5896 4609 894 PMC4137134__F1 Conceivable transforming growth factor (TGF)B1-initiated cellular events leading to myofibroblast activation and extracellular matrix (ECM) synthesis culminating into renal fibrosis 6010 4088 4091 4092 26073 4089 50507 PMC4137413__F2 Genetics of Pulmonary Arterial Hypertension 659 857 440275 3777 PMC4137950__F1 Human respriatory syncytial virus (hRSV) recognition by airways epithelial cells: upon infection, different hRSV components activate pattern recognition receptors (PRRs) 7097 7099 929 4615 7098 51284 64127 57506 3661 3553 3627 6352 PMC4138085__F2 Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury 4615 51135 114609 3654 7189 6885 5606 6416 5608 5601 1432 5602 5599 2353 3725 2689 7043 8741 4050 4049 3458 3593 1442 2776 1616 9641 29110 148022 4792 7297 3716 3718 5594 PMC4139671__F5 Wnt/Beta-catenin signaling pathway 2932 1499 324 51176 PMC4141507__F1 fHLH: becoming a blended family 5873 6813 1130 8546 5551 8676 PMC4145026__F1 Non-coding RNA regulation of synaptic plasticity and memory: implications for aging 23411 7528 627 PMC4147239__F1 MTOR signaling pathway 3667 5728 7248 7249 6009 1977 PMC4147963__F1 Natural killer cell cytotoxicity (NKCC) 637 355 8772 790 PMC4148120__F7 MAPK pathway as an apoptosis enhancer in melanoma 161742 200734 673 5163 PMC4153031__F2 The hypothetical estrogen-induced signaling pathway in neurons 857 4131 351 PMC4155643__F1 Pathways of sphingolipid degradation and synthesis 2181 51703 2182 23305 2180 427 56624 340485 125981 55331 56848 8877 224 79071 54898 79993 83401 6785 60481 64834 253782 29956 204219 10715 79603 91012 401494 201562 9200 51495 PMC4157144__F3 L-Serine Biosynthesis PathwayDe novo biosynthesis of serine is crucial to provide the organism with sufficient levels of this amino acid 26227 29968 5723 PMC4159649__F6 Identified glycotransferases involved in O-glycosylation and associated biosynthetic pathway 2525 2527 64090 51083 2528 10317 23563 10331 124872 6484 192134 718 9245 8702 PMC4167033__F7 IGF but not the EGF signaling pathway is regulated by the NEDD4-PTEN circuitry 3479 1950 3480 1956 3667 5728 4734 PMC4170615__F6 Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma 1398 3725 759 356 355 4149 PMC4172644__F1 Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism 2346 4552 4548 4522 635 4524 6948 5212 875 6573 PMC4175348__F11 A putative scheme for ATF3-mediated regulation of ER stress-induced cancer chemokine expression 22926 1958 467 PMC4176146__F1 The hexosamine biosynthetic pathway and O-GlcNAcylation are shown 8473 1690 10724 PMC4177046__F1 Aberrant Regulation and Function of MicroRNAs in Cancer 54487 29102 27161 PMC4180468__F10 A model for action of DOX within key signaling pathways necessary for LTF 140805 1385 10682 PMC4183521__F5 Neuroendocrine Humoral and Vascular Components in the Pressor Pathway for Brain Angiotensin II: A New Axis in Long Term Blood Pressure Control 551 7175 7225 PMC4185356__F1 Control of endotoxin tolerance by AhR 196 3620 7099 6999 PMC4185425__F1 Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity 324 941 5091 1493 940 7535 4088 PMC4185425__F3 The Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity 324 941 940 1493 PMC4186342__F1 Trafficking of TLR4 7099 929 51014 338382 10890 8766 PMC4189458__F2 Progesterone functions via intrinsic (mitochondria-centered) and extrinsic (cell membrane-mediated) pathway of apoptosis 355 8772 637 56616 PMC4191651__F3 Schematic illustrating mechanisms of SR-A intracellular signaling 4615 9961 7098 54106 3661 PMC4197875__F2 Hippo signaling pathway in stem cell biology and cancer 154796 4771 9113 26524 1499 79923 9421 1045 8320 2625 PMC4197875__F4 Hippo signaling pathway in stem cell biology and cancer 4485 1499 7038 PMC419935__F8 A working model for the CblSTR signal transduction pathway 1356 868 23624 PMC4203564__F1 KIAA1524/CIP2A promotes cancer growth by coordinating the activities of MTORC1 and MYC 1978 6198 4609 57650 1869 1612 PMC4209037__F3 Gene association network (GAN) 3 in lung 64750 6498 9802 5493 1937 51295 2517 PMC4212313__F1 B cell receptor signalling pathway controls B-cell fate and function 4067 6850 2534 695 5336 PMC4213475__F2 Model of the JAK-STAT pathway in CRC with the corresponding significant changes in the signaling circuit activities 122809 23624 1154 6779 4609 PMC4213475__F4 Signaling changes in the T-Cell receptor signaling pathway of human bone marrow hematopoietic stem cells 23624 2534 919 3932 920 387 5788 3937 3702 27040 2885 286204 2353 3551 959 29851 940 PMC4216117__F2 MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells 4087 2475 3660 3551 84807 3569 1432 4794 121457 1051 59330 PMC4217539__F6 Human pre-BCR-induced signal transduction depicted from the current study 7535 5079 5896 PMC4219921__F2 Classical and non-classical pathways of androgen biosynthesis 6770 412 1583 1586 8644 3283 3294 1588 1645 1646 5959 1733 9420 7366 7367 PMC4221550__F3 smicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma 4803 4351 1950 1956 6722 2268 2885 673 4342 4609 PMC4223335__F10 Concerted regulation of NFATc3 by electrical activity and NGF in sensory neurons 4803 4775 2932 PMC4227160__F4 Proposed model of the roles of CDKN1A and KIF20A in cell cycle control via RB/E2F pathway 545 472 1026 1019 1017 1021 995 10112 1062 PMC4227186__F6 TCDD induced HIF-1A molecular signaling 196 405 7422 5281 7019 7351 PMC4228940__F10 Novel Role of Vascular Endothelial Cadherin in Modulating c-Src Activation and Downstream Signaling of Vascular Endothelial Growth Factor 1003 1445 6714 PMC4234068__F1 COMPLEMENT REGULATION IN RENAL DISEASE MODELS 1378 717 730 729 2271 735 966 PMC4235760__F1 MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS 83939 468 10628 835 100126333 PMC4236175__F1 Examining the Polymorphisms in the Hypoxia Pathway Genes in Relation to Outcome in Colorectal Cancer 3091 6387 4015 4282 64344 PMC4240841__F1 Proposed model of Ostf1 in fishes 2645 554210 6093 652 PMC4245458__F2 Regulatory cross-talk between the estrogen receptor alpha and MTA family members 2885 9112 57504 999 9219 PMC4246949__F9 Scheme of the regulatory interactions connecting PREP1 and PBX1 expression with the TGFB–SMAD3 pathway, cellular invasion, and EMT 5087 4088 3725 PMC4248746__F10 Model depicting the molecular mechanism involved in counterregulation of TLR-induced inflammatory signature by dectin-1 7474 6850 4615 3654 1499 8554 PMC4254673__F8 Proposed model for autophagy and metastasis mediated by mTOR signaling 5539 5728 2475 637 572 581 PMC4261819__F1 Network of noncoding RNAs negatively regulates NFKB signaling 958 4615 51135 3656 7189 23118 10454 257397 406902 29775 406947 8945 10365 9314 PMC4264123__F1 Hypothetical diagram of LPS-triggered inflammation and apoptosis pathways summarized in A 929 3929 4615 7187 8772 7189 29110 718 3661 3665 PMC4267896__F3 Central LepRb expression sites and related neuronal circuits 642658 4922 23237 5443 181 PMC4268999__F1 Wnt/Beta-catenin pathway 999 4040 1499 2932 324 4609 7008 PMC4271245__F7 Proposed model linking TBX2 and TBX3 to the TGFB1 signaling pathway 4087 4088 4089 6926 6909 PMC4274748__F4 Inactivating gene fusions of NF1 in lung cancer 4763 5066 1819 51168 51701 5717 PMC4276460__F7 HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells 8772 6774 637 3717 PMC4276888__F7 Schematic of proposed TXNIP/miR-200/Zeb1/E-cadherin signaling pathway 10628 6935 999 PMC4279797__F1 Pharmacology network-based drug repurposing for CMT1A disease 5179 5173 2316 51083 3479 1959 5376 7442 6714 596 PMC4281955__F1 Telling the story of a gastric cancer through sequencing and functional studies 999 7157 2263 7048 1000 1002 1001 PMC4282831__F3 Seeing through VEGF: Innate and adaptive immunity in pathologic angiogenesis in the eye 718 3553 629 727 10371 1604 8829 PMC4284624__F1 ITCH E3 ligase in ATM network 472 83737 9113 3725 2735 PMC4285772__F7 SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model 6774 9021 5970 5728 PMC4285849__F1 Impact of IBD genetic polymorphisms on dendritic cell function 64127 55054 3586 PMC4294682__F6 Proposed model of hPer2 and hp53 interaction and function 4193 7157 581 2810 PMC4295541__F2 Generation of ceramide and FTY720-P 253782 29956 204219 10715 79603 91012 1674 PMC4303448__F1 The IKB kinase complex in NFKB regulation and beyond 23118 10454 3550 PMC4304915__F6 HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism 6714 11336 387 PMC4306304__F1 Hereditary hemorrhagic telangiectasia is a genetically heterogeneous disorder caused by mutations in several genes in the TGFB/BMP signaling pathway 2022 4090 4086 4089 3397 PMC4310328__F1 Schematic figure of the complement system 1401 718 717 1378 1356 10747 727 966 729 730 735 PMC4312948__F7 Role of TRP channels in the vascular system 59341 7442 7220 8989 7226 54795 759 54822 7225 57113 7222 PMC4314215__F4 MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy 6935 9839 999 8091 6659 3371 5962 387 4609 PMC4314580__F2 Signaling pathways in T/NK-cell proliferation 4067 7186 7185 7187 7188 6850 1499 8717 PMC4314728__F9 Schematic of the signaling pathways activated by the P2Y2R in endothelial cells that are thought to regulate vascular permeability 1003 2548 7410 5879 PMC4316180__F3 Tumor necrosis factor (TNF) induced apoptosis pathway and the Fas-Fas ligand-mediated apoptosis pathway 7124 355 8717 7186 8772 PMC4316815__F2 Regulation by zinc of the ERK1/2 signaling cascade 627 2863 1445 PMC4322971__F3 Role of p53 in the progression of gastric cancer 7157 4193 2638 PMC4322984__F9 Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/Beta-catenin pathway 7474 1499 5243 PMC4323172__F1 Both ligands and receptors are single-pass transmembrane proteins composed of different structural domains 102 5045 3516 1950 100188776 PMC4324046__F2 Metabolic reprogramming in rheumatoid arthritis T cells 2539 5209 2194 PMC4324923__F2 Current model of NLRP3 inflammasome activation in RPE 79184 114548 3603 4615 6120 718 PMC4325629__F1 Hedgehog signaling in cancer stem cells: a focus on hematological cancers 5727 6608 2736 2737 51684 2735 64399 55733 8643 374654 27148 595 PMC4327623__F2 The main signaling pathways involved in the neuroprotective action of GDNF on dopaminergic neurons 2668 2674 5979 596 836 PMC4333762__F3 PRb/E2F pathway regulates cell cycle progression 1017 1019 1869 1870 1871 1874 1875 1876 144455 PMC4335176__F2 Pathways leading to stimulation of extracellular-regulated kinase (ERK) and AKT phosphorylation by fluoxetine in astrocytes 1950 1839 1956 PMC4337036__F2 Schematic overview of intracellular antiviral immune signaling in teleosts 4615 29110 3661 3665 103 9636 7098 51284 51311 PMC4338202__F5 Whole Transcriptome Analysis Using Next-Generation Sequencing of Sterile-Cultured Eisenia andrei for Immune System Research 10333 7097 114609 4615 3654 PMC4338781__F3 Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach 2000 1998 6010 2475 3611 PMC4346366__F1 Consequences of tissue trauma on heme catabolism, reactive oxygen species, and polyunsaturated fatty acid metabolism.Notes: Top panel: following tissue trauma, release of free heme can serve as a signal for proinflammatory events 4015 2936 2242 847 5226 5730 5743 9536 5740 PMC4346946__F4 Regulatory mechanisms of actin dynamics in response to DNA damage 6010 3985 133746 PMC4349561__F2 Pathway analyses of direct interactions among transcripts mediated by P4 in the ovary 966 51429 9618 5058 23013 5241 4627 10857 PMC4350422__F1 Immunologic manifestations of autophagy 3603 54106 51284 8408 8678 57506 3661 29110 PMC4352427__F1 TRAIL-receptor mediated signalling pathways 637 666 581 596 7186 8717 PMC4352987__F3 Multiple signaling pathways regulate the expression and activity of Sox9 during chondrogenesis 3091 6469 6662 2627 2626 140628 6660 579 55553 1280 PMC4353374__F2 SIRT1 in synaptic plasticity 4204 627 7528 23411 2475 3984 PMC4355577__F2 Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? 8205 3565 7422 9242 6387 3569 4319 3371 3082 4318 4313 4314 PMC4357026__F8 Diagram depicting the possible activation of TM detoxification of xenobiotics 5243 929 7099 PMC4357835__F2 KEGG pathway analysis 2149 7035 2152 2159 2147 2157 7450 5624 5327 5328 5329 2161 966 718 729 717 720 PMC4359951__F3 Genomic analysis of metastatic cutaneous squamous cell carcinoma 3082 1956 2066 2261 3815 673 64926 5728 4763 2475 4771 6794 545 7157 4609 1030 1029 472 595 1019 1021 5925 54101 8626 84433 1387 2033 4792 4855 4851 4853 PMC4360066__F6 T-cell activation pathway regulating six key activation genes 940 6504 2534 9046 1796 6772 8915 4790 117289 3458 PMC4364402__F2 Models of peripheral and spinal itch circuitry 83737 2922 2925 PMC4364658__F6 MiRNA targeted upregulated genes of Rho GTPase signaling 387 9826 388 29 10566 23365 54509 23229 50649 257106 7247 6010 89846 1124 23370 64333 26230 57381 8874 221472 9901 394 55635 57449 9886 9411 8997 58480 4168 PMC4364827__F3 Activation of the DNA damage response (DDR) after DNA double-strand breaks (DSB) induction in young and old cells 3014 472 9025 165918 641 7518 PMC4367644__F1 IGF-1R Signaling Pathway 3479 3480 5728 5163 572 2475 PMC4367834__F5 Dopamine biosynthesis and degradation and the genes coding key enzymes 1644 5053 7054 4128 4129 1312 224 1621 5409 231 367 6818 PMC4368090__F3 Interleukin-1B and its interacting proteins in Alzheimer’s disease 27040 613 6850 4067 1956 7054 114609 7124 4208 920 100187907 7939 572 6955 387 3565 717 1431 929 51083 PMC4369723__F5 Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B 1950 7039 2885 6774 6772 335 6667 1956 PMC4370503__F1 Vitamin D Receptor Cdx-2 Polymorphism and Premenopausal Breast Cancer Risk in Southern Pakistani Patients 5212 7421 6256 1045 PMC4370592__F6 Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model 842 4824 572 5728 1026 PMC4373479__F1 TLR4 signalling 7099 4615 114609 7189 51135 7187 3661 PMC4374437__F6 Schematic diagram illustrating intracellular signaling pathways in a macrophage involved in cytokine regulation by adrenergic and cholinergic agonists and receptors following lipopolysaccharide challenge 367 3717 3146 6774 PMC4374755__F7 Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners 54106 7187 7189 6772 51135 4615 PMC4376961__F2 Key events in the apoptotic pathway and regulation of apoptosis by sphingolipids 90427 581 572 637 596 8772 PMC4377327__F5 Regulation of microRNA function in somatic stem cell proliferation and differentiation 6502 124540 10451 PMC4379939__F1 As yet unknown side of DC secretion post-TLR activation, and trafficking molecules currently identified in DC function 4118 4615 6810 7189 8673 9341 8766 8773 9554 6809 PMC4380073__F2 Simplistic overview of the top two mutation-enriched transduction signaling pathways in ATC as according to the Genomatix Pathway System 3265 5602 2475 3845 4771 5894 5879 208 3480 5290 673 PMC4380230__F2 Endothelial cell metabolism in normal and diseased vasculature 367 142 2597 1719 3156 4524 387 64902 PMC4380398__F7 Pik3ip1 Modulates Cardiac Hypertrophy by Inhibiting PI3K Pathway 3479 113791 2475 29904 1938 PMC4380423__F5 Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasis 7054 3567 54210 1440 3586 3553 3574 7124 914 6346 1435 1437 3569 PMC4382495__F2 Signaling pathways involved in thyroid carcinogenesis and tumor progression 572 673 999 1499 2475 595 PMC4383269__F9 Human Papillomavirus 16E6 and NFX1-123 Potentiate Notch Signaling and Differentiation without Activating Cellular Arrest 4851 4014 3280 388585 PMC4384750__F9 Model of SOX2 feedback signaling pathway 1956 90427 100132074 6657 PMC4385926__F9 Simplified model depicting (a) Novel positive feedback loop between TGF-Beta-SMAD3 and KLF17 in cancer cells 128209 4088 6304 23705 6678 92140 PMC4388523__F4 Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells 211 2235 7389 210 3145 212 7390 1371 3046 3039 3040 3050 PMC4388604__F1 WDFY1, a new player in the TLR-TRIF pathwayTLR3-stimulated signaling is fully dependent on TRIF, and TLR4 stimulates two signaling pathways, one of which is dependent on TRIF 7099 7098 57590 PMC4390248__F5 Representative protein-protein interaction networks of key pathways and proteins involved in sperm functions 7417 3939 1191 5479 811 PMC4393792__F2 T Cell Metabolic Fitness in Anti-Tumor Immunity 23411 196 3091 581 3458 3002 4170 PMC4394028__F1 TLR/IL-1R, RLR, cGAS, and inflammasome signaling pathways 3553 7099 7100 115004 4118 4615 58484 114548 4671 51135 3656 3654 57506 51311 9447 3661 7098 PMC4395454__F1 MLK3 Phophorylates AMPK Independently of LKB1 998 9053 6416 5606 4135 4133 5604 PMC4397846__F1 Pathway on the left is that of an active cell 1499 324 999 PMC4397969__F1 (De-) Oiling Inflammasomes 3553 409 4615 114548 10454 PMC4399077__F5 Canonical and noncanonical Sap-induced inflammasome activation 3553 3454 114548 PMC4400645__F1 PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through Beta-Catenin Signaling 7484 79633 1499 PMC4401614__F1 Cbl pathways 867 5640 2621 324 8205 940 PMC4402485__F1 Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors 7097 7096 7100 7099 4615 3661 7098 54106 51311 51284 325 PMC4403904__F1 Signaling pathway mediates hepatic fibrogenesis: (A) the TGFB1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFB1/NFKB pathway 4087 4088 4089 4615 7189 PMC4404917__F1 Synthesis of EPA, DPA and DHA from ALA 9415 51 95 3295 64834 3992 54898 PMC4405319__F2 Toll-like receptor 4 (TLR4) signalling 929 3929 114609 4118 4615 3654 29110 7189 3661 910 7099 PMC4408853__F1 Neuronal Ca2+signalling toolkit 6786 57620 84876 80228 PMC4409298__F7 BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses 6347 10413 4090 4086 PMC4411085__F5 Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis 29978 9217 22926 7415 25978 9896 PMC4411553__F4 Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus 3552 3690 3674 PMC4413635__F1 Cyclin alterations in diverse cancers: outcome and co-amplification network 2064 2475 1019 5925 1021 1030 1029 1017 PMC4415606__F4 Arginine deiminase (ADI) hydrolyzes arginine into citrulline 581 435 2475 PMC4417442__F2 HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy 135892 11052 60489 51311 51284 25939 11277 114548 3428 115004 3014 4600 PMC4419202__F1 Most enriched pathways after Foxa1 knockout in male bladders 8320 5054 8995 1316 5004 PMC4419202__F3 Most enriched pathways after Foxa1 knockout in female bladders 5473 3859 3858 7157 5971 5966 8626 4193 PMC4420923__F10 Molecular mechanism for SGK1 signaling and cell survival 2932 10397 150365 PMC4423042__F6 Cartoon representing LPA-activated signaling cascades that regulate OHC motility, as suggested by our results and previous studies (in black font), as well as potential mediators and interactions that require confirmation (gray font) 4018 387 3984 PMC4424331__F11 The molecular mechanism of iron-induced RPE C3 production involves ERK1/2, SMAD3, and C/EBPD signaling 4088 1052 718 PMC4426976__F1 Can we safely target the WNT pathway? 4040 4041 2932 1499 607 PMC4429297__F4 Network-Based Identification of Smoking-Associated Gene Signature for Lung Cancer 1950 4057 55890 55118 10512 1871 1956 3845 21 1576 23556 1875 PMC4431853__F7 House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4 7099 6279 6280 4067 PMC4434687__F4 Conversion of tabersonine to 3-hydroxy-2,3-dihydrotabersonine by the combined action of T3O and T3R enzymes 375056 8190 1733 PMC4436905__F1 Adipocyte secreted leptin and interleukin-6 has a paracrine effect on nearby breast cancer cells 3717 6774 6657 PMC4440219__F7 MiR-503 mediates constitutive suppression of the IGF-1R pathway leading to a less aggressive glioma phenotype 3480 572 595 898 PMC4441984__F4 Scheme of the IL-11/STAT3/CDX2 pathway 6774 1045 6772 2475 9021 4092 596 7422 PMC4442437__F10 Schematic of proposed mechanism for CpG-induced enhancement of the transepithelial transport of H9N2 WIV in nasal mucosa 54106 941 958 6364 PMC4443295__F4 Schematic overview of the 7TM receptors judged to be either stimulating (in green to the right) or inhibiting (red or orange to the left and top) ghrelin secretion directly on the ghrelin cell 846 2867 338557 10267 2696 2695 6344 6651 PMC4443744__F5 Crosstalk between complement and TLR pathways 7099 4615 4280 7018 3569 PMC4449453__F1 Beyond Adjuvants: Immunomodulation strategies to enhance T cell immunity 920 324 940 PMC4451739__F2 Complement during infection with a pathogen 718 721 730 727 729 735 PMC4452412__F7 Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer 6608 8205 7852 51684 6387 PMC4452916__F3 The effects of hrHPV on NFKB signaling 7096 7097 7099 10333 7100 958 8772 7186 7188 7187 7189 8717 8737 7098 54106 51284 81858 7345 57506 5970 5971 1956 3475 3065 8841 PMC4456143__F2 Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer 1499 2932 324 4040 4041 50964 PMC4456163__F1 Putative Regulatory Factors Associated with Intramuscular Fat Content 2006 7052 5236 4504 PMC4456188__F1 Mechanisms by which Beta-cell failure an apoptosis occur are complex, not completely unraveled and involve the interplay of numerous factors and conditions 3667 8660 7249 7248 2932 2475 3651 467 4094 PMC4457722__F5 Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment 4000 847 5901 PMC4461888__F3 p38 MAPK signaling in osteoclasts 7186 7189 27035 9261 4286 4772 6772 PMC4464707__F4 Integrated regulatory graph was constructed as a prediction for the regulatory pathway of IMP metabolism 5471 471 1053 671 914 5728 6722 3308 2551 3306 1045 6955 7057 4332 2697 51573 2120 PMC4467301__F1 Epithelial–mesenchymal interactions mediated by Sonic Hedgehog pathway in embryonic lung 6469 5727 6608 2736 101154687 100506542 2294 3553 1292 2907 4853 5155 11082 1306 2321 5175 80781 140885 PMC4469332__F2 Intracellular levels of BH4 depend on three production conduits the de novo synthesis pathway, the recycling pathway and the salvage pathway 3976 1270 3458 2643 4803 5805 6697 1719 5860 PMC4470732__F1 Scheme illustrating the ASARM-model and the FAM20C kinase link to the FAP pathway: The numbers highlighted in the circles refer to the explanations in the following text 1758 56975 8074 2591 5045 5251 PMC4478474__F2 Gene co-expression network of the 48 genes in the peroxisome proliferator-activated receptor pathway based on their expression values 1376 51 3611 2182 23305 8309 364 51703 376497 5465 9415 5468 335 5346 6257 5360 PMC4480196__F1 MTOR-mediated T cell activation and lineage specification 920 50943 7249 7248 6009 2597 PMC4480752__F7 miR-93 Promotes Cell Proliferation in Gliomas through Activation of PI3K/Akt Signaling Pathway 5728 23035 2309 595 PMC4483595__F1 Three pathways of complement activation 5648 1378 2271 720 717 718 727 729 730 735 966 PMC4486162__F1 Apoptosis: role in myeloid cell development 355 8772 8717 581 637 PMC4486656__F2 Fueling Immunity: Insights into Metabolism and Lymphocyte Function 26227 3939 2271 2744 PMC4490668__F1 Multifactorial pathogenesis of primary Sjögren’s syndrome: interferons as culprits in the self-amplifying pathogenic loop 6741 51284 5132 6738 7054 PMC4491883__F1 NetworkPainter enables researchers to quickly draw publication quality signaling diagrams 613 695 7535 6850 29760 2475 PMC4495377__F5 The flow of glucose carbons in the presence of added fructose in adipocytes 4522 6472 10797 441024 23530 PMC4496349__F6 MiR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer 6427 23119 5328 84289 4899 4790 3516 7157 4609 4149 PMC449769__F7 A model connecting telomere damage signalling and senescence-associated replicative arrest 545 472 3014 PMC4498148__F1 WNT pathway is significantly upregulated in invasive mutant TP53 cells 85458 894 22943 890 6354 3399 2122 25805 1499 7471 4311 4314 3880 5101 6319 1958 6657 PMC4502956__F2 TRAIL signaling pathway and some points of therapeutic intervention 596 4170 637 PMC4504941__F1 Molecular mechanisms of cardioprotection provoked by netrin-1 and netrin-1-derived small peptides 1630 6477 6478 PMC4509066__F2 Signaling pathway of cell apoptosis under cordycepin stress 8717 8772 637 581 317 PMC4510718__F2 Survivin (SVN) pathways to apoptosis 7124 355 581 790 PMC4511863__F6 Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease 6774 7099 4615 4843 79930 7305 64231 54209 PMC4513088__F8 Proposed signaling pathways of PS1-induced apoptosis 596 581 56616 836 842 8772 5660 PMC4515050__F2 Activation of complement system by the amyloid plaques and its dual role in neuronal death 718 715 716 727 PMC4515393__F1 Ceramide metabolic pathways 79603 253782 29956 91012 10715 204219 1674 6611 PMC4520755__F2 Canonical HH-signalling pathway and pharmacological inhibitors targeting this pathway that are under ongoing development as anticancer therapies 6608 50846 51684 2735 2737 2736 11127 595 898 4609 648 PMC4521049__F8 New working model 10148 7099 7412 PMC4522276__F1 Molecular Insight into Dengue Virus Pathogenesis and its Implications for Disease Control 8205 6772 6773 115004 PMC4523862__F8 USP18 negatively regulates NFKB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms 4615 7189 11274 10454 23118 257397 PMC4527020__F1 Location and signaling pathways of pattern recognition receptors 7100 7099 4118 4615 929 7098 51311 51284 54106 3661 3665 PMC4528072__F2 Model for the mechanisms leading from impaired regulation of the alternative pathway to hemolytic uremic syndrome (HUS) 718 2271 7056 727 7450 PMC4528105__F1 A Protein in the Hippo Signaling Pathway Serves as a Point of Cross-talk to the mTOR Signaling Pathway♦ 4485 9113 26524 51421 253260 2475 PMC4530265__F8 Proposed schematic showing targets of edible bird's nest (EBN) action in the insulin signaling pathway 3643 3767 2645 2475 8660 5590 3551 PMC4530521__F1 Mini but Mighty - microRNAs in the Pathobiology of Periodontal Disease 27161 29102 54487 PMC4533772__F2 Analyses of interactions among SHR-specific genes 1591 2638 2021 6258 350 7704 1636 3683 3672 2668 57085 5101 604 4744 1080 6689 10103 2053 55512 7161 1734 6657 148741 3725 PMC4533772__F3 Analyses of interactions among SHRSP-specific genes 1230 2053 57085 2569 183 7704 6261 1543 10993 7423 350 54971 7157 PMC4535331__F1 Reflex control of immunity 23237 3146 4691 PMC4535882__F7 Multiple Protein Kinases via Activation of Transcription Factors NFKB, AP-1 and C/EBPD Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes 207 10000 208 10682 PMC4536973__F1 Physiopathological actions of periostin activation 650 4087 4088 10125 7473 5266 1956 PMC4538335__F1 Lesser-Known Molecules in Ovarian Carcinogenesis 7124 2064 6714 2475 PMC4538424__F1 MicroRNAs as major players in immune-mediated beta-cell damage in autoimmune diabetes 3603 3654 406991 406938 27250 6844 PMC4538579__F1 BAFF-induced activation of NFKB signaling and increased expression of proinflammatory cytokines as procachectic mediators 5971 7186 7187 7189 7188 3603 PMC4545518__F6 Simplified schematic of the canonical Notch signaling pathway 182 285203 10020 23462 3280 3516 PMC4545641__F1 The Expanding Role of Delta-like 4 Mediated Notch Signaling in Cardiovascular and Metabolic Diseases 4853 4851 4854 4855 PMC4546315__F1 The insulin/IGF1R signalling pathway 3480 2885 3667 8660 PMC4546937__F2 COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING 10273 3566 1499 7042 3597 3598 PMC4550414__F5 Network Topologies Decoding Cervical Cancer 7422 2475 1019 595 PMC4551447__F1 Decade in Review-Kidney Cancer Kidney cancer's decade—discoveries, therapies and opportunities 7428 7249 5728 29072 8314 6597 PMC4552335__F6 Proposed pathways through which ethanol administration elicits alterations in cytokine gene expression 3146 7099 929 PMC4553092__F1 The roles of various key members of the LRP receptor family; LRP4, LRP5, LRP6 and LRP8 in bone related traits and bone mass regulation 22943 4038 79412 83999 4041 4040 7804 PMC4558214__F1 Soluble recombinant molecule consisting of the extracellular domains of CD80 linked to the Fc domain of Ig (soluble CD80 or CD80-Fc) has the potential to maintain and facilitate T cell activation through three independent mechanisms 324 941 940 1493 PMC4559511__F2 Complement and adaptive immunity 613 1380 324 942 941 727 718 3458 920 PMC4566117__F4 Surfactant metabolism 21 6439 7080 6440 3170 1050 10568 5091 7808 PMC4572424__F2 Effect of purple corn anthocyanins (PCA) on CCN2 expression 4089 3383 4092 6772 6774 1490 PMC4573851__F1 FANCM and partner proteins in coping with template lesions during DNA replication 57697 91442 545 84126 641 55215 PMC4575611__F1 An outline of the inhibition of type I IFN signaling pathways by viral proteins of KSHV 7099 54106 7098 4615 115004 7187 7189 3654 3665 3661 3428 PMC4576673__F5 Summary of endogenous pathways of AHR ligand synthesis 196 3569 7422 5743 50616 PMC4577305__F2 The Secretory Pathway Kinases 56975 1758 8074 5045 PMC4583820__F1 Involvement of IAP proteins and IAP antagonists in the apoptosis and NFKB pathways [, ] 8772 8717 8737 7186 7187 331 5971 PMC4584349__F1 Metabolites of the folate cycle, transsulfuration pathway, and methionine (Met)-homocysteine (Hcy) cycle 4397 635 4524 875 5091 1491 PMC4586799__F4a The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis 3549 50846 2023 6608 2932 51684 PMC4589430__F2 Immunosuppressive and tumor-promoting functions of TAMs and MDSCs in HCC 929 968 9332 8205 6774 945 PMC4590606__F13 Model of T3-induced hepatic mitophagy 8408 5562 57521 10645 2475 8878 7068 2308 PMC4590678__F1 Genes involved in Parkinson disease and in the autophagy-lysosome pathway 120892 6622 6609 23400 55737 8934 950 27074 6720 11315 7345 2580 4137 10457 4209 84286 1509 7942 10159 65018 25793 23317 7415 8867 PMC4591813__F5 ErbB3 in RAF-inhibited mutant BRAF melanoma cells 2065 2064 3084 PMC4591954__F1 Therapeutic targeting of the canonical WNT pathway 8658 2932 324 1499 960 8549 PMC4592520__F1 MicroRNAs in placental health and disease 29102 54487 27161 PMC4594483__F2 TGFB signaling 7046 7049 6010 4087 4088 4089 PMC4601492__F5 Coronin-1C-mediated Rac1 trafficking 5879 55920 23603 PMC4605623__F10 The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation 2176 814 3925 983 PMC4605830__F3 Phosphoproteins down-regulated in PCP and PCPPPI compared to Sal and SalPPI, respectively, which were significantly enriched in LTP signaling pathway 2904 2902 5604 5579 5581 815 5582 23237 816 9651 818 4133 3708 1387 2332 PMC4609654__F1 The Wnt signaling pathway with selected inhibitors 7480 7471 7472 54894 324 2932 1499 PMC4613246__F4 PI3K-independent AKT activation in cancer 5163 5728 29110 6714 5753 PMC4615219__F1 Aberrant activation of alveolar epithelial cells (AECs) in lung fibrosis 1499 6469 4280 3652 977 100187761 PMC4621423__F2 Schematic diagram that gintonin-mediated in vitro cellular effects through LPA receptors in neurons and astrocytes is linked to in vivo pharmacological effects 4018 3382 759 43 1103 PMC4622843__F4 Interaction network of differentially methylated diabetic genes 5055 5328 3909 1950 7124 4609 1278 7040 1284 2200 PMC4628569__F3 IL-27-induced modulation of autoimmunity and its therapeutic potential 3383 3716 9021 3717 7297 6772 6774 1959 50943 196 2625 3586 PMC4628649__F2 Proposed model of the role of TOX in innate lymphoid cell development 4566 3398 9760 3575 4783 7018 PMC4628764__F1 Heme biosynthetic pathway in erythroid cells 3145 7390 7389 206358 10058 54977 23456 1371 51522 212 5212 5498 2235 55240 PMC4629217__F2 Roles of FXR in regulating lipid and glucose metabolism 338 5465 717 718 8462 4023 355 PMC4631758__F3 Gene regulatory networks involved in photoreceptor development 256297 121643 6096 338917 6258 639 5015 1406 10002 4901 PMC4631976__F1 Death resistance signaling in cancer cells 8717 8772 11035 197259 8737 637 572 581 PMC4632006__F1 Left: the PI3K/AKT/mTOR pathway is mainly activated by nutrients (not shown) and growth factors, binding to receptor tyrosine kinases and activating PI3K 5728 324 659 1499 7249 7248 6009 4090 4086 2475 64798 1975 1977 4920 PMC4640679__F5 Non-biased molecular screening identifies novel molecular regulators of fibrogenic and proliferative signaling in myxomatous mitral valve disease 8325 340419 652 6423 6624 9308 51284 2335 7098 2254 929 1524 6925 23462 6376 4609 860 940 22918 3082 3574 10766 3725 4325 2353 4313 2209 7088 7042 969 150094 7483 PMC4641492__F1 A lncRNA to repair DNA 11100 672 472 PMC4641790__F8 Mammalian target of rapamycin complex 1 (mTORC1) is required for mouse spermatogonial differentiation in vivo 5916 5914 402381 54937 5170 3815 1978 6198 PMC4643669__F1 Novel role of miR-33 in regulating of mitochondrial function 9619 19 7019 4899 5166 114789 1374 54677 3032 PMC4644296__F3 Androgen receptor activation pathways 3570 1956 3716 1499 6774 367 PMC4645376__F6 Schematic overview of M1 protein-induced IL-8 expression in human keratinocytes 7097 114609 51135 3654 7189 4615 PMC4646251__F12 The signaling pathways involved in GnRH-induced ERK activation (red arrows) and ErbB4 cleavage (blue arrows) 3084 1839 2066 1956 2534 6714 5310 PMC4646252__F1 Interaction between SAMHD1 and deoxyguanosine kinase activities in the regulation of mitochondrial dGTP 25939 1633 4860 PMC4647217__F10 microRNA-31 modulates skeletal patterning 5079 7849 5076 PMC4648799__F2 P2Y receptor (P2YR) signaling in neurons counteracts oxidative stress and Alzheimer’s pathology 102 6868 351 PMC4650856__F4 Wnt signaling pathway involved in SPN 999 1500 23600 1499 51176 6932 4088 PMC4650980__F1 Receptor tyrosine kinases and their targeted therapies in gastroesophageal cancers: EGFR, VEGFR and MET 1950 3082 1956 PMC4650996__F8 TRPV1 antagonist-induced hyperthermia involves BAT-mediated thermogenesis 7442 7350 7038 PMC4652152__F7 Ingenuity Pathway Analysis for inflammatory gene expression in females vs 23643 7097 54106 7098 7099 7096 3458 929 PMC4655423__F1 Development of innate lymphoid cells 3398 4783 9760 6095 2625 196 64806 3553 85480 90865 864 3458 PMC4657846__F1 Normal complement cascade 716 715 717 718 727 730 729 735 PMC4658327__F1 Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation 8473 2582 10020 4582 1956 5973 2638 80896 1690 PMC4659440__F3 HGF-MET signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NFKB) leading to increases in cell survival, motility and proliferation 3082 596 572 2932 4193 2475 PMC4663246__F1 Cyclin D1-cyclin-dependent kinase 4/6-retinoblastoma 1 pathway 5925 1021 1019 PMC4665627__F6 Deletion of SPARC Enhances Retinal Vaso-Obliteration in Mouse Model of Oxygen-Induced Retinopathy 6678 3791 2321 PMC4671996__F2 Illustration of Warburg effect in cancer cells 3939 5132 2271 PMC4672198__F2 MITF function in the nucleus of a melanosome to activate melanin synthesis and secretion and melanocyte growth and survival 1908 4254 1910 4157 3815 1499 6663 5077 4286 PMC4673337__F1 Innate receptor signaling and stefin B influence NFKB activation and caspase-11 expression in macrophages 7099 3929 929 114548 4703 834 3606 6651 114609 4615 PMC4674284__F1 A working model of how the NLRC5 ubiquitination and deubiquitination feedforward loop shapes IKK/NFKB activity 7099 7186 7189 84166 PMC4681751__F1 Biological interaction network revealed by Ingenuity Pathway Analysis 3043 7538 22891 653499 5360 348 3858 7124 721 335 11072 10850 3360 23764 5265 336 54210 5624 8871 7462 213 3700 PMC4682379__F4 Transcription_P53 signaling pathway 7422 545 472 8554 1869 1499 9063 5903 2274 7341 7508 7507 9219 4134 6996 PMC4682646__F1 Complement activation, regulation, and molecular basis for complement‐related diseases 717 720 721 4049 1401 2271 1604 4179 57506 966 7448 PMC4685484__F5 HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction 3146 7099 114609 4615 3661 3458 51135 PMC4685960__F3 Endosomal Toll-like Receptors in Clinically Overt and Silent Autoimmunity 6738 51284 6772 3569 7124 PMC4686057__F4 Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators 54749 4081 81539 3679 22854 22807 8038 22998 1829 8728 114882 54842 83879 84230 57575 3675 11113 9315 23531 100302168 23231 4907 4094 10154 55785 54549 158471 10100 25890 6506 9891 3953 9848 144402 116442 PMC4689171__F2 IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas 4615 51135 3654 695 84433 10892 8915 PMC4689294__F1 Wnt canonical and non-canonical pathways 4040 4041 4920 324 23002 2932 387 PMC4689482__F2 ARID1A mutation and anticancer agents on the PI3K/AKT pathway 3845 5728 673 8289 2475 PMC4691138__F1 Schematic presentation of proposed molecular epigenetic mechanism of sulforaphane’s action including interdependence between histone modification and DNA methylation 5111 1786 2810 5728 894 PMC4694690__F1 Clinical use of cobicistat as a pharmacoenhancer of human immunodeficiency virus therapy 283871 9429 1244 6582 55244 146802 6583 6584 PMC4695008__F6 Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2A/androgen receptor signals 6352 7428 367 6935 7852 PMC4696838__F2 MSCs reduce a central profibrotic factor, TGFB1, using STC1 in bleomycin-induced pulmonary fibrosis 5266 2475 7351 641 PMC4705949__F10 Proposed mechanism utilized by HDACi to inhibit osteoblast-mediated protection of AML cells 5478 9368 5493 PMC4706649__F2 Different apoptotic pathways are modulated by PEDF 355 8772 836 841 637 842 581 596 PMC4709758__F9 Signaling pathways of IL-17A in synovial fibroblasts 7124 3654 4615 8717 7186 7188 7189 5970 PMC4710177__F2 Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications 545 472 4193 PMC4710243__F1 Beta-Catenin participates in cadherin-mediated cell adhesion and is a transcriptional coactivator in the canonical Wnt signaling pathway 2932 324 847 PMC4714141__F3 Pathway of microRNA-7 in colorectal cancer 7528 7516 5080 1956 595 581 4313 4318 PMC4715999__F2 Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: implications for disease pathogenesis and treatment 921 6351 6348 933 930 973 974 4067 6850 695 5336 29760 7018 PMC4716629__F1 NFKB/p65 ubiquitination and degradation signaling 150684 64236 6007 51147 PMC4723140__F2 Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone 1892 31 2194 95 PMC4724343__F3 Because KAT2B is a novel genetic susceptibility factor for drug abuse, we built a GeneMANIA () network centered around KAT2B to find related genes that may have functional links to drug abuse 9015 6929 9013 9014 1387 2033 8202 8850 4086 9794 22938 9790 84441 4854 7391 4193 PMC4727338__F2 Interaction between neurotrophins and VEGF 4803 627 2475 PMC4727420__F2 Global view of biological processes and molecular functions of HDL proteins 344 324 341 346 5444 4061 3931 348 5360 55937 347 5950 718 2822 335 6288 336 337 3549 6402 721 7012 7448 6291 197 567 PMC4729166__F1 The activation of the NFKB transcription factor pathway by liposaccharide (LPS), TNFA, high mobility group (HMG)B1, and polymicrobial sepsis 3146 3929 929 4615 7189 PMC4729166__F2 Schematic illustration of the molecular processes leading to apoptosis in renal proximal tubular epithelial cells 355 581 4615 8772 PMC4729769__F7 Schematic Diagram Depicting the Proposed Role of P-gp in the Formation of Peritoneal Adhesions following an Abdominal Operation 7040 4087 4088 PMC4729952__F3 Peroxisomes, fatty acid beta-oxidation and the human deficiencies of peroxisomal beta-oxidation 51 8309 3929 1628 113091 PMC4731498__F2 Placental mTOR as a nutrient sensing signaling pathway 3479 6194 1977 PMC4731654__F3 Wnt signaling pathway 4040 4041 1499 PMC4732610__F5 Transcriptional Analysis of T Cells Resident in Human Skin 7908 7054 3558 3562 7040 3458 3600 3565 3567 3586 6955 920 6957 3596 1437 2919 3456 7124 3122 1435 1440 2920 3589 PMC4733614__F2 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies 324 3458 940 941 PMC4739416__F1 JAK-STAT signaling contributes to the pathogenesis of MPNs 2056 7173 2475 PMC4741283__F1 IL10/IL10R signaling pathway 3569 3586 3570 929 4615 6774 51135 3654 7189 7124 7099 3588 7297 3716 3718 PMC4741450__F9 Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway 545 472 995 891 PMC4741883__F8 Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma 4208 9734 5598 6495 7091 6689 4487 2624 2625 2138 PMC4744516__F1 Long noncoding RNAs in viral infections 7706 57506 3661 83939 283131 105221694 684 10410 100506668 104326052 8519 9636 PMC4747365__F7 Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells 581 842 836 PMC4747800__F1 PI3K/AKT/mTOR pathway and cellular processes controlled by downstream signaling 253260 5728 2475 23035 23239 2932 7249 595 572 2308 10682 PMC4751708__F2 Gene networks 8767 3845 5170 7157 3458 64170 5290 4193 84674 8650 22938 196403 1387 1856 3280 3516 10683 171558 55851 9612 6868 PMC4753639__F8 Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation 1956 7454 4482 50508 PMC4760086__F2 Inflammation in SCD 7412 3383 5281 2919 3146 3576 7099 4283 3627 PMC4763541__F7 Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation 6469 5727 5091 6608 2735 114928 PMC4765871__F8 Refined subnetwork using reconstructed pseudo time-series data (left) compared with experimental validated network in () (right) 4778 2624 2672 8328 PMC4768116__F2 Activation of nuclear factorKB: Canonical and non-canonical pathways 613 7099 958 8915 10892 5971 5970 PMC4770718__F1 PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response 51347 5606 5605 29110 9261 3551 7189 5294 3611 5604 5595 4615 3661 6772 3394 6773 929 3663 5594 8569 4790 7124 409 10725 54472 9448 3845 5062 PMC4773776__F4 PKD2 and PKD3 support EMT and cell migration 5311 10298 5312 28964 PMC4774549__F4 Ubiquitination in the Antiviral Immune Response 115004 22954 81844 79102 6048 PMC4774567__F1 Target function of MALAT-1 in cancer 4054 6667 595 6421 64321 1021 581 PMC4779714__F4 Identification of compounds that modulate retinol signaling using a cell-based qHTS assay 6850 6714 6774 PMC4780366__F4 Molecular hypothesis of tumor progression in uveal melanoma, highlighting the role of PRAME reported herein 2776 8314 23532 1964 23451 PMC4782221__F5 SYK tyrosine kinase: a crucial player in diverse biological functions 126014 54209 6850 5336 759 PMC4782570__F7 Proposed regulatory mechanism of insulin expression by the Wnt/Beta-catenin/NeuroD1 pathway in the hypothalamus 89780 1499 4760 PMC4783254__F2 Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease 3315 7018 2879 PMC4791320__F2 Energy balance signaling, leptin and insulin interaction with possible ciliary genes 3643 3953 6774 7248 7249 6009 2475 5443 181 6753 PMC4792076__F7 Schematic view of B3 integrin–GSK3B and BMP-2–Smad cooperation 650 3611 6714 4086 PMC4793911__F2 Major cellular mechanisms controlling contraction in gastrointestinal smooth muscle cells 342538 2548 25801 387 PMC4796284__F1 Postulated mechanism of PDGF-C-mediated liver fibrosis and tumor in Smad3-dependent and -independent signaling pathways 5156 4088 5159 PMC4796823__F1 Identification of Potential Drug Targets in Cancer Signaling Pathways using Stochastic Logical Models 4582 6714 6774 2475 4609 3725 2353 1977 572 4170 PMC4800795__F10 FAF1 action on the innate-immunity signaling pathway 57506 29110 3661 11124 3843 4599 3434 9636 PMC4811771__F16 SLE risk haplotype upregulates the antigen presentation pathway (APP) 1810 7702 55937 3662 717 629 81844 313 80776 79004 8878 6195 55905 PMC4816162__F1 Mitochondria-mediated intrinsic (a) and death receptor-mediated extrinsic (b) pathway 8717 8772 581 331 PMC4817799__F4 Regulation of neural precursor plasticity within the classical neurogenic zones 429 5728 2638 324 1950 5225 6469 PMC4818970__F3 Growth factor signaling pathway 5728 7248 7249 6009 4193 4609 7157 PMC4820109__F3 Association of MicroRNA-196a2 Variant with Response to Short-Acting B2-Agonist in COPD: An Egyptian Pilot Study 4838 1278 93 7048 3685 5156 4087 4088 6093 2885 1730 4952 PMC4823096__F7 Novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells 1786 23569 6659 11113 PMC4825669__F6a Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy 6423 2487 4208 58498 7483 6774 2353 4622 187 4620 1827 1051 27122 8323 7157 2819 7316 58496 2775 2628 7579 114990 2784 51282 8896 113 PMC4826167__F2 The role of the oncofetal H19 lncRNA in tumor metastasis 283120 2146 8091 100033819 1499 999 PMC4830852__F1 Proteins encoded by genes analyzed in this study in the inhibition of the Wnt signaling 6422 22943 6423 1499 64321 1602 5521 595 PMC4832107__F2 Genome-wide gene expression analysis for S49 (Neo) and S49 (OS 4–25) cells 637 581 790 PMC4833425__F6 Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGFB Signaling Pathway 7042 7040 7043 7124 3596 3598 2693 7189 PMC4833551__F1 Pathways involved in physiological and in pathological cardiac hypertrophy actuated in calcific aortic valve disease (CAVD) 2247 3479 207 2475 PMC4833573__F2 Pediatric Gliomas as Neurodevelopmental Disorders 2260 5781 4763 673 2475 1029 7157 PMC4835044__F8 Schematic depicting the Arg-auxotrophic response 2621 558 673 2932 445 PMC4836210__F4 Graphic representation of apoptosis signalling pathways 8717 8772 637 581 2021 317 PMC4839461__F1 Schematic overview of de novo and salvage dNTP biosynthetic pathways and the mechanism of action of dCK-dependent nucleoside analog prodrugs 7084 100 1633 4860 PMC4839494__F2 Adenosine receptor-mediated signaling pathways 134 135 136 140 3569 PMC4841025__F7 Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice 2475 7008 7124 7186 1147 5578 5581 9021 6774 3952 3717 5562 5465 32 PMC4841221__F1 Changes to coral health and metabolic activity under oxygen deprivation 729 718 9049 717 PMC4845178__F1 Dormancy programs and their potential use in patient treatment 655 7042 5915 5914 7025 6662 79923 6657 4397 PMC4845199__F1 Possible model to explain the involvement of AATF in mTOR pathway 26574 64798 54541 207 PMC4852538__F2 Pathway association between TH and metabolic process via ABCC8 (Kir6.2) (A) 6670 6833 5568 6935 3170 5566 4150 5595 6469 3725 5600 467 1432 5594 367 2354 466 2353 9261 PMC4853753__F5 Cerebellum Development and Tumorigenesis: a p53-centric Perspective 474 2736 2735 595 6608 5727 6095 6469 PMC4855646__F9 Signaling pathways of TRIAD 3181 3182 3064 5347 PMC4856820__F3 Schematic picture demonstrating the myogenesis pathway and the myogenic regulatory genes (highlight in red color) identified in beltfish muscle transcriptome 5077 5081 4617 PMC4857136__F1 Signaling pathways frequently deregulated in MDS 6772 6773 7018 8772 8717 7185 7186 PMC4859809__F1 MicroRNA biogenesis pathways in cancer 26523 192670 27161 192669 23405 57510 54487 29102 PMC4865041__F7 Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database 6418 3423 596 598 664 1029 595 4170 23532 142 135138 942 PMC4867603__F4 Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet 5160 593 47 55902 31 51099 2194 4099 23205 PMC4868905__F2 Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines 7124 6347 3576 2920 6352 2921 PMC4870087__F7 Dominant-negative GA subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease 5332 1749 1750 PMC4870992__F2 Pathogenesis of Hepatocellular Carcinoma 7015 4609 619501 PMC4872452__F2 Network analysis of blood transcripts 53831 966 4082 9535 3449 161003 3661 109 1606 55907 83590 267 1039 PMC4872639__F8 Gq-dependent signalling by the lysophosphatidic acid receptor LPA3 in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA 4018 387 6010 PMC4881529__F4 GPCR-mediated transactivation of EGFR 1950 8038 102 6868 1956 6714 PMC4887650__F1 TLR4 intracellular signaling pathways 7099 4118 4615 51135 3656 7189 7187 23118 257397 8195 3661 PMC4888568__F1 Model of insulin signalling pathway 6714 3667 2885 5728 5266 7249 7248 PMC4889031__F1 Deletion of ERA in uterine epithelial cells leads to infertility, however, this receptor loss does not prevent estrogen induced epithelial cell proliferation () 3480 4582 3479 4057 6774 650 1950 1956 3977 3976 PMC4889230__F1 The stress-triggered signaling pathway leading to DNA damage and cell death 10800 4258 50507 PMC4890876__F3 All of animal cells may be intrinsically programmed to self-destruct 7124 596 8772 8717 PMC4892997__F1 Antiviral Innate Immunity through the lens of Systems Biology 64127 3428 170506 1660 115004 6041 6035 3433 3434 29110 3454 7297 3661 57506 3665 3455 23586 6773 10379 163702 7097 7099 11274 PMC4895251__F3 Proposed model depicts that canonical Notch signaling augments the expression of Klf4/5, resulting in conjunctival goblet cell differentiation by down-regulating proliferation and up-regulating transcription of Muc 5/ac in conjunctival epithelium 9314 688 4586 PMC4896164__F2 Main pathways regulated by the BCR-ABL1 protein 2885 1399 3717 5894 4193 3550 7157 2624 PMC4896923__F2 NRG/Erb signaling in the control of peripheral myelination and axonal growth 9693 2475 2885 2066 2064 2668 627 55914 84894 5979 PMC4899284__F1 Folate-Mediated One-Carbon Metabolism 4522 10797 441024 6472 7298 6470 1719 PMC4900219__F10 Proposed mechanism of DCLF/cytokine-induced cytotoxic synergy 847 7124 6772 PMC4904902__F1 AMBRA1, a novel mitophagy receptor 55626 8678 65018 596 PMC4905365__F1 Targeting the lncRNA-dependent noncanonical Hedgehog pathway by LNA in combination with classical Hedgehog pathway inhibitors 6608 6469 6366 389 6010 11113 2736 400500 11201 PMC4907392__F5 Network computed by Xtalk for crosstalk from the Hippo signaling pathway (A) to the TGFB signaling pathway (B) 4092 10413 25937 4087 4089 4088 PMC4908334__F5 SBGN representation of the haematopoiesis gene regulatory network generated by ChiBE () based on our BioPAX model 861 4091 2623 2078 2313 161882 3087 2624 PMC4909416__F1 The CDC20-APC/SOX2 pathway in human GSCs 991 324 6657 PMC4909440__F1 Mechanistic consequences of PREX2 truncating mutations 80243 5728 5879 1028 3481 PMC4911124__F8 Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection 3182 712 6439 6449 3669 9590 23564 10631 PMC4915362__F4 Converging roles of caspases in inflammasome activation, cell death and innate immunity 8772 581 11035 8737 1540 57506 197259 317 115004 114548 29110 3661 3553 PMC4918703__F1 The podocyte and the glomerular filtration barrier (GFB) 4643 83478 4627 396 8551 7225 64423 2885 81 23607 3675 PMC4918816__F2 Comprehensive Review of Pacritinib in Myelofibrosis 3717 8651 10419 PMC4918817__F2 Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing, and disease 2309 4851 100188776 5081 2247 4617 PMC4922528__F2 TLR and NLR signaling 7096 10333 7097 7099 7100 929 51284 7098 114548 7189 3553 3661 3656 3654 4615 51135 114609 PMC4922562__F1 YAP/TAZ mechano-sensing signaling pathway network 387 6722 4118 PMC4923112__F3 Classification pathway for primary lymphedema 207 2475 5921 147372 2303 57165 2271 2324 3832 7424 2624 PMC4924662__F6 FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3B/Beta- catenin signaling cascade via FGFR4 activation 9965 2932 1499 1003 999 2264 PMC4925727__F3 Tyrosine kinase receptors and their signalling pathways involved in angiogenesis 1956 2885 6714 5728 572 1499 2475 PMC4926327__F7 Mechanism of stimulated VSMC proliferation through the Wnt4/Dvl-1/Beta-catenin signaling pathway 54361 8321 1499 324 PMC4926486__F12 Mechanism of cell death in murine lung epithelial cells after repeated cycles of hyperoxia, radiation, and double-hit combination challenge 581 596 836 PMC4929323__F2 Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury 3084 3976 3977 6774 6010 2475 2066 2065 PMC4930918__F1 p53 integrates metabolic stress signals to direct cell metabolism 5728 355 4193 7249 7248 6009 PMC4930918__F3 p53 directs lipid and amino acid metabolism during stress 355 83939 47 126129 84129 PMC4931361__F1 Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention 4170 8772 581 637 331 PMC4931622__F1 The Wnt/Beta-catenin signaling pathway in renal cell carcinoma (RCC) 3487 11197 324 2932 1499 7428 595 PMC4933697__F2 Signaling pathways involved in platelet-mediated NET formation 7099 5066 1445 6714 7097 4353 PMC4935211__F1 Schematic diagram of TRAIL-induced apoptotic signaling cascades 8772 637 581 331 PMC4937164__F1 Bile acid metabolism in the liver 3949 8213 1581 2264 1810 9965 PMC4937511__F10 Three pathways identified as altered based on the 12 SCI biomarker candidate proteins as input 2194 213 2821 2806 8178 5465 811 226 PMC4938032__F3 Signals shared after brain injury and in the NSC niche 4087 4088 4089 7039 1950 1956 2475 2247 6469 2670 10215 PMC4938774__F7 Elevated integrin A6B4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer 10971 9635 5376 7525 7529 7431 5296 3265 4486 284217 5578 1956 3911 2534 3912 4316 207 6310 977 4609 3918 4149 7709 239 667 8061 3692 3726 PMC4939511__F2 Signal pathways of migration inhibitory factor (MIF) 4282 972 960 3725 PMC4944657__F6 Antagonizing integrin beta3 increases immune suppression in cancer 8205 3566 7099 6850 6772 6778 PMC4945713__F3 Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease 7054 1103 3977 3976 4803 PMC4949263__F2 Horizontal cell fate and cell type formation 3975 256297 5640 3670 121643 PMC4949713__F3 WNT/B‐catenin signalling pathway 324 2932 1499 PMC4957398__F2 Signaling of pexophagy by ROS, hypoxia and inhibition of PEX5 export from peroxisomes 472 5830 4077 8408 7316 PMC4958247__F10 Ehrlichia chaffeensis TRP120-mediated activation of canonical Notch signaling pathway and inhibition of TLR2/4 expression 6868 4851 7097 7099 PMC4960093__F3 General summary of altered mitochondrial functions in cancer cell life and death 4609 3091 7157 581 596 PMC4970297__F6 Model summarizing the role of the HH signalling pathway and its primary transducer, GLI2, during mES cell cardiomyogenesis 2736 2626 55897 4208 1482 6910 6608 5727 51684 2737 90525 PMC4977549__F1 ‘Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients’ 867 3685 2147 1302 2773 2353 2776 729230 2778 3656 7157 8651 6774 6772 6722 3690 5970 3929 4772 5894 4775 4893 387 9261 1432 4615 8784 4982 3845 7099 2932 596 54205 5045 1147 8915 5598 PMC4979999__F6 Exercise Activates p53 and Negatively Regulates IGF-1 Pathway in Epidermis within a Skin Cancer Model 3486 3479 3480 4193 5728 PMC4980649__F1 Main WNT/Beta-catenin pathway involved in cancer and stem cells 1499 2932 6657 324 79923 6929 2103 595 PMC4981436__F4 The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine 5465 5468 7068 7067 5914 6256 5915 2099 5916 PMC4981669__F4 Possible mechanisms for the synergistic immune stimulation of TLR2 and NOD2 ligands 4026 7096 7097 10333 4615 3569 PMC4981669__F5 Possible mechanism for the antagonistic effect of Lpp and RNA in innate immune stimulation in monocytes and macrophages 4026 7096 7097 10333 4615 3663 51311 51284 3606 7124 PMC4981729__F1 Proposed regulation of HSC quiescence by paternally imprinted DMRs 100033819 283120 3481 2475 PMC4983011__F1 Processes involved in particle-induced pro-IL-1B expression 90865 6761 4827 3146 PMC4986634__F7 Mechanism of hepatocarcinogenesis promotion via HBV-induced ROS accumulation 9021 6774 595 PMC4988307__F1 Sulforaphane regulates Keap1-Nrf2-ARE signaling pathway and induces phase II metabolic enzyme expression 2810 9817 367 PMC4992466__F1 Pathways involved in physiological and in the pathological cardiac hypertrophy of calcific aortic valve disease (CAVD) 2247 3479 207 2475 PMC4992754__F1 Sonic hedgehog (SHH) signaling pathway 5727 6608 894 595 4609 2305 596 PMC4996658__F3 Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development 100188776 4087 4086 4088 PMC4997609__F6 Wedelolactone enhances osteoblastogenesis by regulating Wnt/Beta-catenin signaling pathway but suppresses osteoclastogenesis by NFKB/c-fos/NFATc1 pathway 2932 1499 860 4772 PMC5001910__F3 A guide to immunometabolism for immunologists 2597 3458 114548 3553 PMC5002299__F1 Regulation of TLR4 signalling by the ubiquitin-proteasome system 7099 4118 4615 7187 7189 7375 9100 10868 11274 23118 257397 1540 114803 7874 90268 3661 9958 PMC5003378__F9 Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems 929 4615 54472 51135 3654 7189 5966 PMC5003543__F4 Working model of consequences of PREX2 truncating mutations 80243 5728 5879 1028 3481 PMC5005393__F1 Demonstration of how gene ontology annotations lead to understanding of biological networks 37 6258 33 10999 1376 4023 PMC5006394__F2 Metabolism on Foxp3 expression and the generation of Treg cells 940 5728 2475 2308 2309 2146 50943 23411 PMC5006627__F1 Interaction between the canonical WNT signaling pathway and other signaling pathways implicated in MPNST tumorigenesis 340419 7852 8658 5728 2932 324 1499 4609 595 332 51176 4040 4041 PMC5007850__F7 Diagram summarizing the proposed mechanism by which MACC1 drives resistance to trastuzumab 346389 3099 3939 PMC5008685__F1 PERK-dependent Unfolded Protein Response 83939 468 595 PMC5009750__F1 NFKB pathway genes with correlation to HOXA1 expression in breast cancer 3932 27040 5335 472 7535 29760 5579 613 6850 4067 8837 331 596 7124 8717 4791 7706 4790 3929 929 114609 5743 7189 23643 2920 1270 5328 4803 959 958 7187 7186 8600 4049 4050 4055 8740 6387 PMC5010470__F1 NF-kB signaling pathways 3550 5970 5971 7128 92797 PMC5010489__F2 Molecular mechanisms of innate immune inhibition by non-segmented negative-sense RNA viruses 3454 3455 7297 3716 57762 6773 6772 57506 7187 10010 3661 3665 PMC5010673__F2 Summary of interactions involved in Wnt signaling cascades inferred to regulate NC biological functions 11197 2487 1855 1856 1499 23002 58480 2932 8312 324 4214 4134 8945 2033 26108 607 7088 7089 59343 1487 1488 56998 85407 3725 595 894 896 4609 7424 PMC5010756__F4 Sensing of HMPV by different PRRs and modulation of the IFN response by viral proteins 57506 3661 51284 4615 7297 3716 3665 7098 7099 PMC5014572__F3 Roles of MAS-related G protein coupled receptor-X2 (MRGPRX2) on mast cell-mediated host defense, pseudoallergic drug reactions and chronic inflammatory diseases 2056 4155 594857 117194 84876 80228 PMC5014907__F3 CD4+ T cell activation by antigen presenting cells and the IL-12/STAT4 pathway 3663 8651 7128 7132 324 941 942 3458 1493 940 3575 3932 3594 6775 920 7297 3595 3717 3394 PMC5015539__F2 Restoring immune tolerance in neuromyelitis optica 960 920 930 100133941 10113 PMC5015648__F2 AB-crystallin negatively regulates multiple steps in the intrinsic (mitochondrial) apoptotic pathway 581 842 836 PMC5021219__F1 MOLECULAR PATHWAYS: JAK/STAT PATHWAY: MUTATIONS, INHIBITORS, AND RESISTANCE 8651 3717 10419 PMC5022960__F4 Regulating signal pathway related to gastric lipase (LIPF) and diacylglycerol kinase A (DGKA) in gastric cancer (GC) 8513 4862 1606 9575 405 1051 4654 3065 PMC5023176__F13 Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis 6772 3717 5880 PMC5023837__F2 Ingenuity Pathways Analysis of the identified methylated targets 1356 84504 1499 4314 84231 4137 5565 27129 10142 7503 150483 375056 4741 PMC5024694__F1 Simplified model of the canonical Wnt pathway and inhibitors 6423 4040 4041 2932 324 1499 2475 607 PMC5024698__F8 Mechanism for HKa-induced endothelial apoptosis and inhibition of angiogenesis 55824 3932 1445 PMC5026403__F2 Complement activation and immune regulation 717 1675 629 718 1356 727 PMC5037084__F1 Molecular mechanisms contributing to liver steatosis following hepatitis B virus infection 2168 338 7038 355 6319 9370 PMC5037390__F6 Hypothetical mechanistic network derived from predicted upstream regulators for genes found to be differentially expression in chondrocytes in transition from monolayer to alginate bead cultures (redifferentiation) 7042 348 3725 468 4780 4792 6662 2353 2920 8553 1958 467 1280 3091 10457 PMC5039188__F1 TLR signaling overview 7097 10333 7096 4615 51135 3654 3656 7189 54106 51311 7098 51284 8195 7187 29110 3661 3665 7100 7099 PMC5040224__F2 Major regulatory pathways involved in the regulation of Runx2, a chief transcriptional regulator of osteogenesis 650 652 22943 27123 2932 4090 4086 1499 100188776 51176 860 PMC5040452__F13 Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (Bubalus Bubalis) 7908 7054 7040 1437 3458 7124 1440 765 2920 PMC5046039__F2 Molecular regulation of MSCs during bone formation 3549 6608 1445 860 5741 659 1749 324 1499 1950 PMC5046039__F3 Bone remodeling: (a) in precursor cell stage, the macrophage-colony stimulating factor (M-CSF) binds to its receptor (c-Fms) 860 1749 4488 1277 6678 3549 7006 100124696 695 29760 7189 1611 6850 PMC5053480__F4 Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation 9939 353 1070 4151 477 10631 5816 6902 4831 3927 2244 1277 6434 84316 2335 26135 9406 1381 4191 1311 6428 1303 4632 813 4507 2331 PMC5054901__F2 MiRNA function in the immune system 4615 3654 7189 29851 5728 23035 PMC5056258__F1 PI3K/AKT/mTOR pathway is a critical pro-survival cell signaling pathway within NETs that mediates cell growth and peptide translation 5728 7249 7248 2475 PMC5058662__F3 RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney 7124 3553 3569 7097 207 208 10000 3725 7099 6352 6351 6348 2353 941 942 958 PMC5061805__F2 Mechanisms involved in the delay of therapeutic response to classic antidepressants in MDD patients 627 2475 29904 PMC5065302__F6 Mechanisms through which rolipram (ROL) attenuates pain behavior in bone cancer pain 3553 5142 6347 729230 PMC5068231__F7 Cpb1–C3–C3aR pathway amplifying p38 MAPK signaling downstream of TLR4 and Ifnar activation in macrophages 718 3458 1360 7099 7124 3569 4843 PMC5068240__F10 Model illustrating the mode of action of RLTPR in T cells 940 2885 9402 920 PMC5069291__F2 Schematic model of the Wnt/beta-catenin pathway in Alzheimer disease 4040 4041 324 2932 1499 5465 PMC5069610__F3 NMI inhibits cancer progression 22943 7046 999 89780 1499 4087 4088 4092 2932 4089 9111 9839 51176 6929 6925 PMC5069779__F5 MIIP competing with Rac1-GTP to bind the PAK1-binding domain 5879 60672 5058 PMC5073094__F2 Stimuli for degranulation of mast cells and basophils and interplay/overlap with type II-IV reactions 4056 6916 240 10800 7512 1610 10 83737 PMC5076460__F4 Global gene profiling of aging lungs in Atp8b1 mutant mice 5293 100187761 1387 4151 5925 2152 5611 PMC5076471__F1 Inositol pyrophosphates and their corresponding bisphosphonate analogues 9807 51447 117283 9677 23262 PMC5082570__F1 Mammalian choline degradation pathway with DMGDH as metabolic branch point 27232 29958 572 51268 1757 PMC5082787__F10 Schematic illustration of Ro inhibiting autophagic flux and sensitizing chemoresistant esophageal cancer cells to 5-Fu-induced cell death 2100 1111 653361 1536 PMC5085631__F6 Model showing how decreased expression of SRSF2 affects apoptotic pathways in renal cancer cells 7133 3604 8717 7186 8772 8738 8837 331 599 581 PMC5086000__F1 Inflammasome Activation Mechanisms during Bacterial Sexually Transmitted Infections (STIs) 4615 114548 10392 3553 9447 PMC5086033__F1 Microenvironmental Regulation of Hematopoietic Stem Cells and Its Implications in Leukemogenesis 9242 2296 6387 1000 5783 1499 3953 PMC5086377__F1 TNF signaling pathway anomalies through antiapoptotic signaling by TNFR1 helped by upregulation of TRAF1 and inhibition of proapoptotic TNFR1 signaling by BIRC1/3 caspase inactivation 3558 958 8717 8772 3717 7186 3055 6775 4067 4609 PMC5088527__F7 Linking the circadian clock with the NAD+ salvage pathway 23411 10135 9575 PMC5094186__F1 (1) Nicotine binds to the nicotinic acetylcholine receptor, causing a conformational change that opens the receptor's ion channel and allowing entry of Ca2+ and Na+ 23621 1950 10718 2475 6714 PMC5095301__F7 Schematic diagram illustrating inhibition of HMGB1-TLR4 signaling pathway by dexamethasone in renal ischemia reperfusion injury 3146 7099 1636 3553 PMC5096382__F4 DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HEPATIC PROTEOME PROFILES IN 6 MONTH OLD ADULT OFFSPRING 2746 635 191 217 213 2949 8991 PMC5109916__F1 Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3 5163 5728 2932 PMC5110029__F1 Type I interferon signaling and type I interferonopathies as currently assigned 5422 10535 79621 84153 11277 115004 57506 25939 11274 9636 3661 5692 6773 6772 5696 10379 5684 54 7297 3454 3455 3716 PMC5111721__F3 NAD+ metabolism is compartmentalized 23057 10135 22933 64802 23411 51548 23410 23409 23408 PMC5112273__F2 How autism-risk genes regulate neuronal structure and their sites of action 144165 100170220 85358 9228 5728 2475 9844 8831 4204 1859 83992 26047 4685 23394 23026 627 134957 PMC5112569__F6 Regulation of Sirt1/Nrf2/TNFA signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity 8717 2475 9817 23411 64147 PMC5114407__F7 Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1 1021 1019 595 1017 898 PMC5115734__F5 Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement 7390 727 210 7389 2235 1371 PMC5115901__F10 Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury 10394 5923 4018 387 PMC5117143__F7 ATR is required to maintain G2/M checkpoint integrity and prevent apoptosis induced by proliferation-associated DNA damage 581 718 545 472 PMC5118783__F3 Roles of Nanog in Cancer 6657 79923 6774 1499 PMC5120225__F2 Signaling pathway of liver fibrogenisisThe injured liver produces various cell factors, which can activate transforming growth factor beta (TGFB) and platelet-derived growth factor beta (PDGFB), and bone morphogenetic protein (BMP) 5155 4087 4088 PMC5123688__F6 TLR8 couples SOCS-1 and restrains TLR7-mediated antiviral immunity exacerbating West Nile virus infection in mice 51311 7015 581 PMC5123939__F1 Two-signal model for NLRP3 inflammasome activation 846 222545 64127 10392 57506 79184 8772 140609 3654 114548 3553 PMC5123939__F2 Activation for non-canonical and alternative NLRP3 inflammasomes 114548 7099 4615 8737 8772 140609 PMC5124559__F7 Schematic representation of the peptide generation pathway 3817 1369 3426 8029 367 6927 2033 1499 672 PMC5125891__F3 Sphingolipids in Mitochondria 355 7124 8717 8772 581 637 331 PMC5130286__F3 Working model 6120 3654 7189 7422 PMC5132409__F3 Retinoid transformations and enzymes of the classical and intraretinal visual cycles 6121 9227 5959 6120 50700 57665 PMC5136547__F1 Innate immune response against rotavirus in intestinal epithelial cells (IECs) 7297 3716 6772 6773 7098 7187 7189 57506 3661 3725 2353 6041 6035 3627 PMC5136711__F1 Diagrammatic representation of the extrinsic and intrinsic apoptotic pathways 355 56616 581 842 836 8772 PMC5138060__F1 TNF axis in cancer progression and metastasis 7124 7186 8717 8772 PMC5142168__F11 Inhibition of HCO3− absorption by HMGB1 in the MTAL 3146 6010 6093 PMC5142237__F1 The canonical and noncanonical pathways by which the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is activated and elicits an inflammatory response 3553 7099 114548 834 PMC5143759__F2 PIN1 dysregulation and targets in hepatocellular carcinoma 5300 2475 1499 595 4851 PMC5146200__F1 Priming and activation of the NLRP3 inflammasome 7099 3146 114548 PMC5154833__F1 Therapeutic Relevance of mTOR Inhibition in Murine Succinate Semialdehyde Dehydrogenase Deficiency (SSADHD), a Disorder of GABA Metabolism 50846 7054 570 PMC5160413__F1 RA pathway is differentially regulated in stem cells from VS and SC fat depots 7490 216 8854 220 157506 9249 4256 5918 5327 7025 5915 3201 5742 2152 1030 1004 4211 1513 4311 3371 5168 5308 1410 PMC516236__F1 Simplified representation of molecular mechanism involved in insulin signaling pathway that regulates glucose transporter (GLUT4) translocation to cell membrane 3667 5266 5728 5163 PMC5166550__F9 Signal pathway of IGF-1 by exercise 3479 2475 5163 PMC5167996__F7 A model on how BLM complex promotes FANCM recruitment to stalled forks and replication traverse of ICLs 57697 545 641 PMC5171903__F9 GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment 79623 2260 6659 2247 PMC5173045__F7 Proteinase-activated receptor 2 promotes TGF-Beta-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGFB type I receptor ALK5 4087 4088 4089 PMC5173152__F6 Wnt/Beta-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling 1499 51176 2033 PMC5192357__F1 Action of blockade of inhibitory pathways or activation of costimulatory pathways to promote CD8+T cell priming after vaccination 958 970 1493 942 940 50943 PMC5192396__F2 Inhibition of ribonuclease L (RNase L) activation by picornavirus proteins 6041 57506 3661 3665 9908 10146 PMC5193387__F4 Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example 8473 2582 10020 4582 5973 1956 2638 80896 1690 PMC5206652__F1 Identification of genetic susceptibility loci for intestinal Behçet’s disease 254827 22932 51752 51046 494143 2353 6903 122651 351 6272 29937 PMC5207147__F13 Proposed model on the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1signaling axis in HGF-mediated lamellipodia formation 3082 8877 124976 PMC5209488__F6 Summary of the mechanism of Dicer regulation in osteogenesis 5728 324 1499 406991 860 PMC5209581__F5 Phosphatidylinositol 3-kinase (PI3K) pathway: Activation of class IA/B PI3Ks occurs through the stimulation of receptor tyrosine kinases, which is induced by insulin and the concomitant assembly of receptor–PI3K complexes 5728 4193 2475 2308 572 PMC5216790__F6 Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with Beta-catenin-dependent and Beta-catenin-independent signaling pathways 89780 7474 2535 4919 4920 4040 1499 4609 PMC5217035__F7 Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling 5447 581 7939 PMC5218554__F9 Wnt Signaling Prevents the AB Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons 89780 4040 2932 324 PMC5225396__F1 Possible roles of lncRNAs played in the context of RNA-RNA interactions 51433 659 59345 103 3696 6780 7046 90 PMC5259880__F3 The molecular mechanisms dysregulated in PD and thought to lead to DAergic neuronal cell death 6622 27429 23400 25793 120892 8398 PMC5260050__F2 Pathway map for selected proteins encoded by genes that were upregulated in baseline systemic juvenile idiopathic arthritis (SJIA) samples 4615 3654 7189 3659 6772 3725 PMC5265847__F3 TP53-centered protein–protein interaction network identified based on the Level 2 gene set using Ingenuity Pathway Analysis 6003 694 92421 6659 10346 1602 149628 356 57619 3559 10580 5777 7157 50507 3604 7159 688 4026 50848 4854 8842 5008 PMC5272937__F1 The HCV interactions (both direct and indirect) on the hepatocyte insulin signaling pathway 5266 5310 5311 2475 3667 PMC5275769__F4 miRNAs enriched with OSCC target mRNAs of the neurotrophin signaling pathway 1398 673 3845 627 126669 356 387 11108 581 3725 5970 PMC5278183__F1 Regulation of Ciliogenesis by Inputs from the Cell Cycle 3796 146057 57787 6790 5347 347240 79598 10013 4751 PMC5281575__F1 Metabolic control of macrophage activation 7099 7124 3566 6778 47 3565 PMC5282447__F2 Summary diagram of JAK/STAT and MAPK signal transduction 1270 1271 1950 1839 2246 2247 6464 3716 2670 51286 PMC5282886__F5 Critical factors involved in IGF-IR-mediated EMT process 8838 51072 4582 1499 999 PMC5286959__F1 SCFFBW7 ubiquitin ligase targets SOX9 for proteasomal destruction 1956 3845 2475 6662 PMC5288206__F6 Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas 6557 65125 595 PMC5290741__F5 Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine 5728 10000 7248 7249 6009 2475 7097 7096 4615 PMC5290970__F8 Signaling switch between hyperglycemia and normoglycemia 2885 3667 5266 PMC5292191__F2 Extrinsic and intrinsic pathways of apoptosis 355 8772 637 581 PMC5294251__F7 Proposed model for the CD271 regulation and potential downstream effects mediating drug resistance and metastasis 545 7153 472 5591 9656 3014 4803 2258 10635 4751 PMC5294487__F1 Steroid hormone synthesis and endogenous oestrogen metabolism in humans 1583 1586 1588 1576 1543 1312 PMC5297631__F1 Inflammatory role of phagocyte apoptotic pathways in rheumatic diseases 8772 637 317 PMC5297658__F1 Representative apoptosis pathway and associated factors 355 8772 637 581 PMC5297661__F6 Protein association networks 1889 1636 3416 815 824 816 8754 23621 5664 5594 4137 23385 55851 6300 3308 10972 1432 5728 3320 3326 3306 7314 7337 7321 7319 7324 7323 7325 7336 PMC5301276__F2 Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases 8821 5728 5163 207 208 10000 PMC5302955__F6 IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin 3480 545 3667 5163 PMC5302973__F7 Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells 7291 999 2932 1499 960 PMC5304257__F2 miRNAs control inflammatory response in ECs 10365 2919 6347 PMC5310720__F1 PD genes and autophagy-endolysosomal pathway(s) 55737 8867 2580 11152 65018 23400 23208 25793 6609 PMC5312414__F1 Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway 5728 7249 6009 2475 PMC5312548__F9 The role of NAD+ in the macrophage metabolic switch 3091 10135 23411 PMC5318160__F5 Glucocorticoid-driven network links many of the top-ranked PLSR genes 2475 23500 2638 7704 2322 9575 54541 9975 5187 8864 2289 1843 9510 7294 1051 5599 5594 26253 1432 PMC5329888__F3 Sex determination within individual XY supporting cells depends on the level of Sox9 expression.A 6736 284654 1499 6662 2254 PMC5330314__F7 High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity 718 3553 727 PMC5331729__F4 Roles of LncRNAs in the malignant transformation of breast CSCs 100124700 3236 9869 6774 6657 PMC5336563__F2 Regulatory networks of selected lncRNAs involved in the development of HBx-HCC 1499 728655 619501 1017 652995 1021 595 898 1621 PMC5337876__F10 Schematic diagram depicting proposed mechanism for the Wnt signaling pathway activation during differentiation of ADSCs into insulin-producing cells 4040 4041 1499 PMC5338169__F2 The endothelial cell and monocyte in early stages of atherosclerosis: potential mechanisms of milk derived bioactive peptides 7099 729230 948 PMC5342378__F8 PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer 5077 7545 1647 595 1021 1019 1000 999 PMC5343774__F3 Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway 50943 8205 3553 PMC5346542__F1 Metabolic reprogramming drives: (A) T-cell fate and function and (B) antitumor-immune response 2475 3091 4609 1493 941 PMC534909__F2 Fas receptor pathway of apoptosis 355 8772 637 790 PMC534909__F3 Cell survival signaling pathways 572 355 581 637 PMC5349223__F6 Regulation of Posttranslational Modifications of HMGB1 During Immune Responses 10333 114609 4615 54472 7189 51295 3146 PMC5351668__F6 Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets 9365 3426 718 720 2159 5624 5327 10544 727 4067 7448 PMC5352108__F1 Long non-coding RNAs in anti-cancer drug resistance 5728 6935 60674 283120 1499 PMC5355696__F3 Signaling pathway networks 6714 5228 3791 4772 3845 6300 6009 253260 5829 4773 PMC5357299__F8 Schematic overview of the proposed iOGN:TLR4 signaling pathway 7099 4969 114609 4615 7189 PMC5358695__F4 Layered network between rituximab and myasthenia gravis (MG) 581 3586 717 2209 2212 940 2214 942 3123 2213 3125 9103 7124 3569 693122 PMC5358695__F7 Layered network between muromonab and myasthenia gravis (MG) 940 673 2212 3265 581 1493 942 3586 2213 2214 5133 1380 3558 9103 3566 3559 3002 1432 3565 3125 3107 29851 3569 919 693122 917 3845 7124 3106 915 3105 916 355 3122 PMC5359264__F3 ReactomeFIViz: from disease pathway to PPI network 6667 1871 1869 2077 1870 7027 7316 PMC5359687__F1 Heterogeneity in Cancer Metabolism: New Concepts in an Old Field 2539 5226 7086 29968 3939 2194 4199 2746 2744 PMC5361605__F4 GIST and apoptosis signaling 581 596 572 317 54205 56616 842 839 840 836 332 PMC5362638__F2 MyomiR interaction with Akt-mTORC1 signaling pathway 3667 6194 1977 PMC5363412__F1 Top Network Associated with the DERs Selected by the Criteria of 4-fold Change in Whole BloodThe functions related to this network are defined as cancer, organismal injury and abnormalities, and reproductive system disease 596 5310 1843 57822 1870 1869 898 1871 8742 5465 10309 4609 595 4087 4088 PMC5363613__F6 Integrin A2B1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma 619501 79633 558 595 PMC5367651__F3 Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells 472 637 5366 27113 54205 842 64065 64393 3479 5728 4193 PMC5368188__F6 Transcriptional networks that regulate LIN28B expression 51548 4609 5978 389421 PMC5368692__F2 MYC-dependent metabolic reprograming in immunity As schematically shown here, MYC regulates immune cell metabolic reprogramming in different contexts 4609 4610 613 PMC5369369__F55 Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/Beta-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease 9817 4040 4041 324 55364 1499 PMC5372366__F4 Molecular Therapy for Degenerative Disc Disease: Clues from Secretome Analysis of the Notochordal Cell-Rich Nucleus Pulposus 7045 5660 6678 PMC5372489__F2a Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus 3630 3643 6514 777 8660 3667 5581 8835 122809 PMC5372827__F6 Strategies of enhancement of folate level in plants 1725 1719 2356 8836 PMC5374322__F1 Step-wise tumorigenesis in colorectal cancer 324 1499 3845 4089 7157 673 5290 5728 7048 PMC5374322__F2 Genes frequently mutated in colorectal cancer and their relationships with miRNAs 5728 7048 4089 1499 27250 4609 7157 389421 3845 PMC5374322__F3 Relationships among miRNAs and canonical Wnt signaling, metastasis, and tumor-initiating cells 8549 55366 4041 4040 2932 6934 1499 10642 8650 8091 430 PMC5374731__F2 Schematic summary of genetic abnormalities in ATL cells 940 84433 22807 7161 5335 5336 2625 3181 8915 1880 387 4851 339855 3662 6774 PMC5378051__F3 Homologous mammalian and fungal host-defense pathways that signal through prion conversion 114548 57495 5548 PMC5378054__F4 Regulation of cellular senescence by transforming growth factor B (TGFB) signaling 6667 650 652 655 1874 PMC5378112__F1 Genetic model of the insect melanin biosynthesis pathway () 15 7054 1644 PMC5378188__F2 Animal NLRs provide structural insights into plant NLR function 10392 114548 4671 58484 PMC5380843__F8 Proposed model for activation of IFN by doxorubicin bypassing IFN antagonism by Ebola virus VP35 protein 115004 7153 57506 472 29110 3661 3665 PMC5381110__F6 Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues 26227 6470 2653 2731 10249 27232 1757 29958 PMC5381938__F1 Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy 940 3458 920 324 1493 PMC5382109__F5 Extrinsic and intrinsic signaling of BCR signaling activates NFKB in B-cell malignancies 613 8915 4615 84433 10892 5971 PMC5382109__F6 Therapeutic targets in B cell lymphoma of NFKB activation 4615 613 6850 4067 2353 695 10892 3550 974 PMC5383353__F1 IRS4 signaling in malignant cells and therapy resistance 3667 8660 3084 8471 9542 PMC5383719__F3 Low-avidity signaling of B2-integrin regulates toll-like receptors (TLR) signaling in macrophages 7099 6714 4615 6850 23607 PMC5384497__F1 Schematic view of the anti-inflammatory roles of SLPI in obesity-related atherosclerosis pathway 7099 6590 3550 3383 PMC5385655__F6 Schematic representation of the effect of S3I-201 in obesity-induced extensive mammary hyperplasia 6774 999 4313 PMC5388758__F5 Gene networks associated with intestinal processes and diseases 5728 716 729 721 717 730 718 727 735 5447 177 6095 PMC5390606__F2 A simplified network identified by IPA pathway 891 1027 999 595 7157 PMC5393036__F7 Schematic model of NKILA functions during the invasion-metastasis cascade in NSCLC 4087 4089 105416157 4088 PMC5395201__F3 Inactivation of Retinoblastoma Protein in Uveal Melanoma by Phosphorylation of Sites in the COOH-Terminal Region 1021 1019 1017 PMC5395663__F1 Mesenchymal-­epithelial interactions during digestive tract development and epithelial stem cell regeneration 7474 6423 6422 56033 1045 6662 2625 2294 2295 6469 PMC5396097__F3 Autophagy-mediated regulation of macrophages and its applications for cancer 6347 3569 7097 7099 3570 729230 2475 PMC5396125__F1 Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway 10910 64127 10392 329 331 330 23118 257397 PMC5399014__F6 Metabolic pathway of lipid accumulation in oleaginous microorganisms and related key enzymes 2539 1431 355 PMC5400562__F8 Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2/3 signaling pathway 4087 4088 847 4089 1728 PMC5406893__F7 Summary of the survival and growth phenotypes in breast cancer 1956 3480 3845 5894 572 4170 2475 PMC5407862__F1 Management of EGFR-mutated non-small-cell lung cancer: practical implications from a clinical and pathology perspective 3082 2621 1956 673 5728 2475 5594 PMC5407986__F2 Mitochondrial Control of Innate Immunity and Inflammation 1283 57506 51035 79671 1329 29110 3665 3661 5091 7189 9830 8717 10010 7186 7187 5093 5094 5688 64750 PMC5408584__F4 Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias 355 6256 5465 1376 2166 27163 PMC5409774__F7 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) 7097 5879 54472 114609 8772 3929 929 23118 7189 958 51135 1513 130749 54106 3661 7098 PMC5410960__F4 Rb1 pathway 1029 1019 5925 PMC5412884__F1 Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease 89780 8549 324 5728 1499 28514 54567 8650 1950 1956 PMC5413910__F4 TNF-induced canonical NFKB and apoptosis pathways 7124 8717 8772 1540 9825 7186 81858 7939 90268 PMC5417249__F1 Shared coregulator GRIP1 in the GR and type I IFN signaling networks 3455 7099 3454 4615 7098 7297 3716 3665 23426 3661 10379 PMC5418445__F1 Tumour angiogenesis: molecular pathways and potential interventional strategies 3082 5879 6010 PMC5420432__F1 mTOR signaling pathway in podocyte autophagy 2475 7248 5310 PMC5425951__F2 Ingenuity Pathway Analysis network showing the relationships between several assayed genes (emphasized with black arrows) 1755 1510 3105 10462 7297 1522 11006 PMC5427104__F1 Activation and evasion of lectin pathway (LP) of complement 717 727 718 721 PMC5431893__F1 Pathway of “aryl hydrocarbon receptor signaling”-initiated smoking-related cancer 5053 405 1846 4091 6597 196 57491 PMC5431987__F5 Ingenuity Pathway Analysis cancer network from RNA-Seq breast cancer samples 2331 3084 1956 5621 338442 836 7360 604 9839 4739 PMC5432547__F4 Action network of predicted targets of miRNAs overexpressed in GML mice stomachs 5728 3717 94241 1959 PMC5434646__F6 Proposed mechanism of the interplay between mitochondrial complex II and FH in the stabilization of the HIFA signaling pathway 6389 6390 6391 6392 2271 7054 PMC5436143__F6 Gain of function Beta-catenin in the uterine mesenchyme leads to impaired implantation and decidualization 3976 3977 5241 3549 5727 650 54361 PMC5438978__F1 Regulation of IL-1/18 production and current IL-1/18 antagonists 114548 828 3556 9051 10068 PMC5439543__F1 CHEK2 pathway 472 993 994 995 675 672 10783 2305 PMC5440090__F2 Anti-tumor immune response through CTLA-4 and PD-1 pathway blockade, and T-cell signaling in the treatment of melanoma 23255 940 325 PMC5441763__F5 CD19 is the linchpin between CXCR4, the BCR, and the actin cytoskeleton 930 6387 7852 6850 2308 PMC5445935__F2 Correlates of metastatic melanoma response to checkpoint inhibition 940 1493 567 PMC5447271__F1 Illustration of Wnt signaling cascades 4041 6104 8312 2932 324 1499 51701 PMC5447946__F5 ENOs and 14-3-3 in neurodegeneration 6622 572 5340 120892 2932 114548 PMC5448185__F1 The role of ITSN1 in Reelin signaling in the forebrain 1600 717 7436 348 6453 PMC5448608__F5 Schema of BTB and CNC homology 2 (BACH2) interaction in the nuclear factor‐KB (NFKB) signaling pathway 7189 23118 257397 PMC5451598__F12 Schematic pathway illustrating the inhibitory effects of BMP4 on PDGF-induced calpain-2 activation, cell proliferation, and collagen synthesis in normal and PAH PASMCs 652 5053 7040 PMC5452982__F3 Regulation of muscle growth and regeneration by the immune system 3458 3659 4283 4261 4656 7124 3146 7099 7186 4615 7189 6347 5081 4851 6772 PMC5458189__F7 Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head 2475 2932 1499 PMC5463383__F7 Proposed model showing the mechanism of action of PPARG agonists (TRG and RSG) on TGFB1-induced fibrogenic activation in human primary intestinal myofibroblasts 6965 4087 4089 PMC5466503__F2 Melanocyte activation integrated in the schematic view of the UV-induced pigmentation pathway in the normal skin 3976 3082 4157 6662 4286 7306 1638 PMC5466503__F4 Melanocyte differentiation 7048 5077 51176 6663 4286 4089 6497 1638 PMC5466514__F1 Cancer cells take advantage and manipulate the ROS-Ca2+ interplay in two ways: 1) by inhibiting large ROS-Ca2+ surges that mediate apoptosis (red pathway) 7225 6786 84876 93129 90550 7226 7442 7220 PMC5466966__F1 Major Anti-tumorigenic pharmacological properties of thymoquinone 6714 6774 1019 596 4318 PMC5468686__F2 Protective or pathogenic roles of innate lymphoid cells (ILCs) in liver diseases 4283 90865 6761 50943 6778 3597 324 149233 6774 PMC5469213__F2 Tuberous sclerosis complex and mTOR pathway 7248 7249 6009 PMC5473901__F8 Summary Effect of miR34a 407040 596 1786 PMC5477576__F3 Extrinsic apoptosis pathway 355 8717 8772 23118 257397 637 PMC5483997__F1 Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition 64750 57154 4090 4086 4091 4089 6010 3397 PMC5484415__F3 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy 2744 29968 440 2875 PMC5484492__F5 Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy 5087 1523 55742 253260 3169 3987 406923 5770 2308 6850 442898 6774 3643 6247 100126348 2206 4609 2324 406976 406977 5979 3265 3497 3912 406910 2205 PMC5486401__F2 Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases 8717 8772 581 5970 5971 PMC5486846__F1 The extrinsic and intrinsic apoptotic pathways, as well as the inhibitory effect of various IAPs on pro-apoptotic molecules 7124 8717 8772 637 4671 331 PMC5487013__F7 Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells 147111 9350 4040 4041 25805 50964 PMC5487013__F8 Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells 51176 2113 22943 817 4609 7473 9350 80319 2239 7481 7020 7474 8322 7855 2118 11197 6423 64321 27121 2494 2625 4773 6591 PMC5490158__F4 Upstream regulators identified by Ingenuity Pathway Analysis, predicted to participate in the regulation of gene expression upon A2B-adrenoceptor activation in A7r5A2B vascular smooth muscle cells 6376 6347 196 1301 4879 PMC5494602__F9 Model of TRAF3-dependent regulation of RIG-I signaling pathway by NS1/126-225 1283 57506 7187 29110 3661 7706 84282 PMC5496266__F6 The roles of microRNA families in hepatic fibrosis 3082 898 7046 7048 PMC5496628__F1 mTOR is the essential signaling pathway for nutrient sensing and apoptosis protection in the B cell 3667 8660 7249 7248 10628 PMC5499521__F1 Curious origins of Angioimmunoblastic T-Cell Lymphoma 54790 1788 940 29851 6774 3569 387 6775 604 643 2534 920 PMC5499884__F10 Molecular indices of viral disease development in wild migrating salmon 5610 3565 246778 7099 57506 6773 3605 55008 2064 11274 51588 10379 6347 4599 64135 968 54106 7098 3659 54739 3458 1956 5696 5599 5698 3665 2475 2247 2353 5329 7422 51284 54941 7157 3558 1432 1950 6714 2147 7040 5604 PMC5506270__F1 T cell signaling, activation and antigen recognition 940 920 324 PMC5509726__F6 Protein-protein interaction networks of lipid metabolism related pathway enriched genes 948 4547 23171 57678 19 1606 255189 23646 5320 8526 246 8399 84647 26279 PMC5511151__F7 Mechanisms underlying crosstalk between Wnt/Beta-catenin signaling and insulin signaling via Irs1 during hepatocarcinogenesis 619501 3667 8660 PMC5511157__F6 Mediation by Menin of milk protein synthesis through the PI3K/Akt/mTOR signaling pathway in mammary epithelial cells 5618 2475 1977 6194 PMC5511646__F2 Cardiac hypertrophy (a) and cardiac fibrosis (b) signaling pathways 2932 10014 2626 PMC5512555__F3 Notch signaling in the mammalian ovary 100188776 182 2697 2661 9210 344018 2701 3624 5879 6774 3714 7784 668 3955 135935 346673 399823 28514 54567 2626 1583 3283 1588 6770 PMC5516298__F1 FAM13A regulates the CPT1A–FAO pathway in chronic obstructive pulmonary disease (COPD) 1374 10144 95 847 1376 PMC5516800__F3 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? 26227 6470 29968 4522 PMC5517472__F3 Overview of the metabolism of hepatic methylamine 635 4397 10400 7038 875 PMC5518849__F1 An overview of one-carbon metabolism and the established/future therapeutics that target this pathway 1719 26227 4522 7298 4524 PMC5520463__F1 The serine synthesis pathway (SSP) diverges from glycolysis utilising the intermediate 3P-glycerate, which is converted by PHGDH, PSAT-1, and PSPH into serine and then glycine 3845 26227 29968 5723 PMC5522964__F1 Epithelial to mesenchymal transition (EMT)-inducing transcription factors and the reported E3 ubiquitin ligases that govern their stability 144699 4193 26259 999 PMC5524794__F1 Protoporphyrin IX biosynthetic pathway in the shell gland of brown egg laying hens 54977 210 1371 7390 5498 10058 7389 2235 28982 9429 PMC5527809__F2 Interaction network and subcellular localization of differentially regulated genes by dasatinib in K562 cells 8835 9659 57520 9021 1154 64375 3708 467 2115 969 399 4609 3087 114625 7494 22822 55366 23764 9592 PMC5527897__F5 Ganglio‐series glycosphingolipid synthesis pathway 6489 7357 8705 6482 2583 30815 PMC5527946__F1 Regulation of autophagy 3845 2885 7249 7157 7248 7405 5289 6009 596 PMC5531310__F1 Downregulated sphingolipid metabolism in idiopathic pulmonary fibrosis (IPF) lungs 8560 55331 6609 55627 1901 8698 8877 PMC5532733__F2 Molecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation 3156 1958 9453 PMC5533325__F5 Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) 7097 5879 54472 10333 8772 114609 3929 929 23118 51135 7099 7189 958 1513 54106 3661 100187907 7098 PMC5535871__F5 Functional overview of ANRIL and pathways 9055 3569 472 1869 PMC5537818__F6 Underlying mechanisms of n-3 PUFAs protecting metabolic syndrome 355 7038 338 4023 4615 PMC5538118__F2 Molecular map of pathways that lead ROS to cause OPC dysfunctioning in SZ 5154 2534 7248 7249 2475 6009 5465 5156 PMC5538796__F1 Endothelial cell metabolism in health and disease: impact of hypoxia 5209 355 1374 5629 PMC5539397__F1 Effect of RBBP5 inhibition on glioblastoma 7099 29110 5929 6657 79923 PMC5540209__F1 PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression 3480 10399 2885 3667 PMC5540723__F1 PD-1 pathway signaling and the targeting of the PD-1 pathway during cancer immunotherapy 324 941 942 940 PMC5542228__F5 Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance 57521 1978 9470 6195 253260 1975 6197 6199 2475 8986 6194 208 5563 6198 5290 5170 51719 64223 PMC5543744__F6 Proposed mechanism of hypoxic-conditioned secretome effects on liver regeneration 9021 6774 5163 23411 PMC5547743__F7 Proposed model for I-SMAD-regulated signaling that enhances HSPG expression, cholesterol uptake and HCV entry 654 655 1956 238 3949 975 4092 4091 7436 PMC5549027__F15 Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway 1613 2475 581 PMC5549331__F1 Molecular pathways of macrophage polarization 7099 4615 3662 6778 6774 6772 3661 3663 4360 3627 PMC5557313__F1 Illustration of the complement activation pathway with annotations for quantified glomerular proteins in progressive versus non-progressive IgAN patients 1401 716 1378 717 721 718 10878 3078 3080 81494 729 730 7448 735 966 PMC5558095__F7 Noncanonical GLI1 signaling sustaining LAC growth and CSC maintenance 6608 7422 2735 9429 6469 8828 PMC5562164__F3 Innate Immunity to Intracellular pathogens: balancing microbial elimination and inflammation 3603 8678 51083 8408 9636 55054 718 PMC5562214__F7 Cardioprotective effects of macitentan 1509 335 5740 22933 2934 5444 23395 26060 5506 7466 23417 493829 9370 2335 948 1499 3053 462 6772 7498 5176 2632 1464 1339 6443 PMC5564615__F7 Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway 6667 1869 4193 PMC5566109__F5 CircRNAs and the related signaling pathways in human cancers 83737 55771 1017 898 1021 1956 5293 1499 6928 PMC5570368__F7 Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing 3725 5468 5465 2033 PMC5571156__F7 Mechanism of QE action 4087 4088 4089 PMC5571732__F1 Methionine metabolic pathway 4143 4548 635 191 875 PMC5573869__F3 Regulation of the G1/S cell cycle checkpoint pathway by Pontin/Reptin at multiple levels 2932 1499 4609 595 1869 1019 1021 11319 1017 PMC5576560__F2 Ten Strategies of Interferon Evasion by Viruses 3455 3454 8205 7297 6773 6772 5184 10379 57762 6041 PMC5577170__F7 Schematic representing the key role of IFNA and LPS-activated monocyte-derived exosomes in brain endothelial stimulation 7099 5764 3383 3553 3569 6347 7412 PMC5578007__F2 Notch signaling modulates endothelial cells’ (EC) fate associated with neointimal hyperplasia 4851 4855 1003 PMC5578163__F1 Physiology of the VHL-HIF pathway along with proposed etiopathogenesis that leads to metastatic ccRCC 7428 1956 7852 2056 648 7291 2475 1236 6469 4286 999 PMC5579652__F1 MYD88-mediated TLR4 signaling pathway results in the production of pro-inflammatory cytokines 7099 929 114609 4615 51135 3656 PMC5581716__F2 The ferroptosis pathway and the inducers and inhibitors of ferroptosis 130749 2879 7216 6520 23657 PMC5584166__F4 Signaling pathways that can cross talk with TNT formation 7942 2309 4485 PMC5587602__F7 Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters 1803 4280 3553 3603 PMC5588108__F3 The Hedgehog signaling pathway 6469 6608 5727 51684 648 PMC5591914__F5 5-HT2A receptor antagonist contributing to DM-induced cardiovascular complications 3383 7412 6010 PMC5593568__F7 IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NFKB pathway and reduction of JNK in HNSCC 3577 3579 10392 PMC5593677__F2 Promising landscape for regulating macrophage polarization: epigenetic viewpoint 208 7189 3656 3654 406938 10682 51621 3624 6387 1316 5316 4087 3065 6772 3716 PMC5595801__F2 Regulation and interaction network model of 17 cytokines 3567 3553 3562 3552 3596 3578 3565 3569 3558 3586 PMC5596246__F1 Caspases in extrinsic and intrinsic apoptosis 8717 8772 581 317 PMC5596246__F4 Caspases regulate RLR and TLR antiviral signaling 7706 51311 51284 7098 57506 54106 4615 29110 8717 8772 11035 8737 3661 3665 PMC5596544__F8 Schematic of the AcSDKP/FGFR1/MAP4K4 pathway suppression of TGFB/smad signaling and EndMT 10818 9448 4088 7048 7046 2260 PMC5596586__F6 Diagram showing the mechanisms of CHAC2 494143 22926 468 637 581 PMC5597737__F1 Activation of NFKB and IL6/STAT3 signalling pathways in NPC cells by multiple EBV-encoded latent gene products 3569 7187 7186 6774 7189 1540 7098 602 5971 3661 3570 PMC5598536__F2 Canonical pathway illustrations of CBA classifier 4094 2729 2512 PMC5601305__F1 Mechanisms used by Toxoplasma gondii, type I strain, to modulate mainly immune system at its favor 1950 3458 4843 3620 355 7040 637 6778 PMC5601671__F6 The apoptotic signaling pathway of microRNA-155 in splenic lymphocytes 7133 581 100303716 PMC5602287__F1 Summary of iAs effects on regulators of G1/(S)phase 993 9134 1017 1869 1870 PMC5602684__F1 Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12–CXCR4 associated biological regulatory network 1950 6387 1956 7852 5174 6714 5728 4193 672 PMC5606117__F4 Crosstalk between the genes (in blue) obtained from the systematic review of LR and their biological functions in the dopaminergic neurons 2534 6714 3356 6622 7316 1312 6532 1644 1813 1565 4524 6833 PMC5606204__F4 Regulated Cell Death Pathways 8772 11035 317 842 841 843 840 836 834 837 PMC5607250__F9 Predicted regulation relationships between differentially expressed miRNAs and target genes based on KEGG pathway 7498 693216 5618 PMC5611863__F1 Landscape of new drugs in lymphoma 613 6850 695 973 974 930 4067 29760 4827 84433 7006 100124696 3702 660 7294 1956 2353 3725 2064 2066 640 638 3718 PMC5612430__F1 Choline and methyl group metabolism and its relation to DNA methylation and influence on regulation of gene expression: a simplified diagram 1103 635 55349 4548 4143 4144 PMC5614474__F3 Transcriptional programs controlling endocytosis and genetic reprogramming by endocytosis 1956 7157 7942 55332 92421 857 PMC5615369__F1 Novel aspects of tumor biology and translational approaches using zebrafish models 5897 2625 920 117581 PMC5618525__F3 Signaling events downstream of IL7R (depicted in purple) and the pre-BCR (depicted in black and red) involved in the regulation of RAG1/2 expression and Ig light chain recombination 3575 3718 2308 896 4170 596 5896 3535 PMC5618569__F1 Stages of autophagy 5371 8408 9706 55054 PMC5618570__F1 Insulin/insulin-like growth factor (IGF) system 3479 3481 3482 3480 207 PMC5618627__F3 HSP40 family member, DNAJB6a (MRJ), prevents tumor formation through inhibition of the Wnt pathway 89780 7471 22943 4040 4041 324 2932 1499 10049 4487 PMC5620328__F1 Long non-coding RNAs associated with non-small cell lung cancer 1950 1956 652995 2475 PMC5621755__F2 AhRR with the canonical and non-canonical AhR pathways 196 5971 57491 405 6346 PMC5622153__F3 BACE1-dependent NRG1/ErbB4 signaling pathway involving in the pathogenies of schizophrenia 2066 1950 23621 10718 3084 PMC5623081__F7 TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated with Hyperlipidemia 7097 10333 948 51135 3654 7189 5336 6714 6850 4615 114609 PMC5625807__F2 Genes identified from the enrichment analysis were significantly associated with OSA comorbidities 154 3356 3358 3952 3359 200909 6532 3953 3990 1909 PMC5627579__F3 Proximal tubule (PT) phosphate reabsorption 9213 8074 5741 PMC5629070__F6 Schematic representation of the proposed IR signal diversification by ligand-induced crosstalk with molecular partners 3485 780 857 3489 3481 2475 PMC5635727__F2 Lut alleviates I/R injury by inhibiting apoptosis by up-regulating AKT, increasing BCL-2 protein and decreasing BAX protein 5350 5478 581 9817 PMC5635761__F1 Possible Nucleic acid sensors participation in HBV pattern sensing in the life cycle of HBV 115004 57506 51428 3428 9447 4615 3661 3665 54106 51311 51284 7098 PMC5636111__F4 Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia 5136 109 5533 805 1956 1387 2033 1499 6934 8322 5330 3725 7473 23236 5599 5568 5880 7157 PMC5638134__F6 Chloroformate Derivatization for Tracing the Fate of Amino Acids in Cells and Tissues by Multiple Stable Isotope Resolved Metabolomics (mSIRM) 26227 29968 6470 2731 10797 PMC5640840__F8 Schematic diagram showing the observed changes induced by HCV in endoglin-associated cell signaling pathways 4086 3397 596 79923 3280 595 6657 6659 PMC5641207__F1 Single-cell genomic analysis of head and neck squamous cell carcinoma 4609 7422 6667 1958 4088 4089 5970 PMC5644625__F1 Activation of the complement system 716 718 717 721 727 735 729 730 7448 720 PMC5644891__F1 The leptin/melanocortin pathway 6492 627 4160 181 4852 5443 3953 PMC5645395__F5 MiRNA-mediated gene regulation involved in two functional pathways in the early stage of KIRC and KIRP (miRNAs: pink diamonds; genes: ellipses) 4609 7157 3717 5728 4893 1387 2033 472 10735 PMC5647277__F1 Current view of the mechanisms responsible for activation and modulation of the reproductive axis in birds and mammals 1628 2796 1734 2140 7252 9575 PMC5649128__F1 Role of Platelet-Derived Transforming Growth FactorB1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis 7189 4087 4088 PMC5649368__F3 Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors 355 1674 2146 1956 367 6714 PMC5649420__F2 Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program 25805 7099 1956 4067 387 4615 2534 7189 4089 5728 PMC5650615__F1 Simplified scheme of innate immune recognition mediated by PRRs 3654 7189 114548 58484 9447 10392 64127 3663 7187 3661 114609 4118 7099 3553 PMC5652672__F2 Somatic mutations in salivary duct carcinoma and potential therapeutic targets 140805 5728 367 PMC5661129__F2 Crosstalk between cancer and cancer stem cell-related pathways 1950 182 1956 5624 27022 23242 PMC5661397__F6 Pentose phosphate pathway (dotted lines) and associated metabolic pathways (solid lines) 367 6652 7086 5631 PMC5663620__F1 Novel strategies to prevent the development of multidrug resistance (MDR) in cancer 355 5243 581 PMC5664079__F3 PDK1 and the Salvador/Warts/Hippo (SWH) pathway 5163 60485 27040 PMC5664350__F3 Summary of intracellular TLR4 signalling pathways in nucleated cells 929 114609 4615 51135 3656 3654 7189 7187 3661 7099 PMC5665080__F1 SREBP-driven mevalonate pathway 47 3157 3156 4598 10654 4597 3652 2224 38 23590 PMC5666320__F6 Model of Rho/F-actin pathway repression by EWS-FLI1 via MRTFB/YAP-1/TEAD transcriptional perturbation 6876 57496 7168 800 PMC5666637__F2 Summary of the transforming growth factor B (TGFB) signaling pathway and mutations causing connective tissue disorders 7042 7043 4087 6497 4088 4089 PMC5667541__F4 Protein O-GlcNAcylation: emerging mechanisms and functions 8473 8408 3786 181 10724 PMC5668671__F2 Toll-like receptor signaling 7097 7096 7099 7100 10333 4615 114609 7098 3661 51284 54106 PMC5669850__F1 Role of the inflammasome in chronic obstructive pulmonary disease (COPD) 7100 7097 114609 7098 55183 54106 7189 10392 64127 PMC5671742__F2 Anticancer drugs that induce oxidative stress on endothelial cells 3084 2066 2064 PMC5673544__F1 Tandem repeat variation near the HIC1 promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer 23411 7507 7508 2067 PMC5674651__F2 Homocysteine metabolic pathway 635 4548 4524 875 PMC5674931__F5 The role of metabolism and microRNA (miRNA) in daunorubicin and cytarabine treatment 1576 1633 100126296 PMC5675569__F3 Network of selected factors influencing myofibroblast survival/resistance to apoptosis 7040 1950 7070 5728 331 836 1499 6678 PMC5676473__F1 Schematic diagram of Nrf2 signaling and regulation in the corneal epithelial cells 50507 9817 1728 PMC5679442__F1 Stromal niche for epithelial stem cells: a template for regeneration and a brake on malignancy 6469 7472 652 3082 3479 655 2252 2690 2099 PMC5679744__F7 Fgf10-Hippo epithelial mesenchymal crosstalk maintains and recruits lung basal stem cells 4485 7477 2255 3550 PMC5680590__F7 CAV1 orchestrates the TGFB response in HCC 619501 857 1956 50507 90427 PMC5682227__F2 PID gene defects in the IFNG pathway 9636 3594 7297 1536 3551 4792 2624 3394 6775 6772 3716 3460 3459 958 PMC5682960__F7 Working model of the action of PEDF + DHA in enhancing corneal nerve regeneration 4852 6698 7432 8482 4803 5340 627 2821 PMC5685326__F1 PD-1 in T-cell activation, exhaustion, and effector function 324 941 942 940 PMC5686097__F2 Cellular metabolic pathways driving mononuclear phagocyte inflammatory vs 3099 47 5979 717 718 3553 PMC5686665__F1 Lipogenesis, sphingolipid, and PA synthesis pathways 47 2194 2531 64781 7357 PMC5696504__F7 Osteogenic Wnt/Beta-catenin pathway and its interplay with polyphenols 50964 367 324 1499 607 860 PMC5696728__F2 Oncolytic virus mediated enhanced anti-tumoral immunity, including enhanced CAR T-cell recruitment and effector function 3383 5066 115004 355 3458 4283 3627 6955 6351 958 29851 25981 920 55509 PMC5700013__F2 PCSK9 in neuronal apoptosis 255738 842 836 596 581 PMC5701508__F8 NFKB pathway.Notes: (A) The canonical pathway starts with binding of TNF to its receptor, activating the IKK complex, which phosphorylates IKBA, promoting its polyubiquitination and further proteasome-dependent degradation 7124 4050 4055 5971 51199 PMC5704042__F2 Structure of SCF/c-KIT proteins and downstream signalling pathways 3717 2885 6714 2475 4067 572 896 1017 PMC5704294__F1 Proposed activation pathway and domain structure of Nrf1 55768 4899 4094 84301 1283 PMC5705153__F8 Cisplatin or LA-12 enhance killing effects of TRAIL in prostate cancer cells through Bid-dependent stimulation of mitochondrial apoptotic pathway but not caspase-10 8772 637 331 PMC5705614__F4 Schematic depicting the metabolic regulation of the mammalian Hippo signaling pathway 387 5879 154796 PMC5710110__F2 Transforming growth factor B (TGFB)-induced Smad signaling pathway 100187907 4089 4087 1019 1024 1025 3399 3398 3397 PMC5710380__F1 Mast cells and their receptors 4286 7097 7099 117194 PMC5710802__F1 cGAS-STING pathway senses cytosolic dsDNA 115004 3661 10084 3586 3569 PMC5711528__F1 Metabolic pathways controlling activation and lineage specification in the immune system 3716 3717 6774 50943 5867 7436 3949 948 960 2539 55872 PMC5714221__F9 H1 involvement in the repression of the interferon response 55601 3661 3665 3659 6773 6772 7297 3716 10379 PMC5719258__F5 An integrated model for valve development 1499 10365 9620 2624 57216 7358 2303 5629 2626 6910 4772 2050 1948 3680 6385 5175 PMC5720977__F1 Wnt and Hippo signaling network that either promotes or inhibits Wnt signaling through cytoplasmic and nuclear interactions of the two pathways 1499 10413 9113 26524 2932 324 8945 9686 6910 PMC5722594__F1 Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer 613 940 6850 7535 PMC5723018__F9 FKBP11 affects the formation and progression of AAD 51303 4318 7412 3553 PMC5723907__F1 General induction and receptor signaling pathways of type I and type III IFNs 3454 3455 3717 7297 3716 57506 6772 10379 3661 3659 3665 PMC5727168__F7 Hypoxia/IL-6/lncTCF7/TCF7/Wnt signalling axis in glioma 4282 3570 6932 6774 595 6657 999 PMC5727303__F2 Inhibitors of Wnt signalling 8658 1499 324 607 4040 4041 PMC5729527__F2 Scheme of reported cross-talk between core Hippo pathway components and wt (left) or mutant (right) p53 9113 26524 4193 11186 23411 4485 PMC5729532__F3 P53–p21–DREAM–E2F/CHR pathway 1026 2305 1874 1875 1869 1870 1871 PMC5730868__F1 Self-renewal pathways in CSCs (A) Wnt signaling pathway, (B) SONIC Hedgehog signaling pathway, and (C) Notch signaling pathway 6608 6469 324 1499 5727 51684 79923 6657 8643 PMC5731952__F7 Comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis 84033 387 1499 6010 PMC5732537__F8 Virus-induced endoplasmic reticulum (ER) stress and the consequent downregulation of the stimulator of interferon genes (STING) pathway in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) 22926 115004 6048 29110 3661 PMC5732752__F8 Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle 2932 2597 10818 PMC5733031__F1 Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram-negative bacteria 7099 8651 4118 4615 9021 3661 PMC5737877__F8 Proposed model for the regulation of BATF3 by S1P signalling in HRS cells 8877 81537 1901 9294 PMC5741523__F1 Hepatitis B Virus Persistence 7097 7099 100187761 29110 57506 3661 PMC5742161__F11 The illustration of CGA protecting against liver fibrosis in vitro and in vivo by regulating miR-21-regulated TGFB1/Smad7 signaling pathway 4087 4088 1081 4092 PMC5743619__F1 Schematic presentation of different pathways involved in PCa disparity.1 1950 3569 3586 6774 367 5163 2475 PMC5743757__F2 Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets 3569 6774 3717 4602 5901 114609 3570 PMC5743771__F2 Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease 10113 19 355 3949 9619 1071 4023 29881 64240 7038 64241 PMC5744151__F2 Restriction factors block multiple stages in the influenza virus life cycle 124872 684 896 54453 9375 10269 10581 10410 9636 22954 10346 4343 4940 6041 6035 81844 5318 9188 3669 PMC5745276__F1 Wnt pathway can be classified as canonical and non-canonical 54894 84133 2713 1499 PMC5746461__F5 Serotonin neuron development: shaping molecular and structural identities 3642 2624 4010 2625 6581 6571 6532 121278 1644 2643 4129 5860 4128 2019 3061 3351 2893 1902 3350 147 246213 PMC5748797__F1 Formation of resveratrol metabolites by various UDP-glucuronosyltransferases (UGTs) and cytosolic sulfotransferases (SULTs) in humans 54658 6783 6817 6799 6818 54600 PMC5750128__F7 Schematic drawing showing the effects of IGF-1 and ALC on prepubertal Kp synthesis and release 3479 3480 6247 7249 6009 2475 3667 PMC5751286__F2 Schematic view of (A) the NFKB signaling pathway and (B) the JAK-STAT signaling pathway that contribute to the pathogenesis of psoriasis and its novel targeting molecules 29949 3569 11009 57506 PMC5757132__F7 Proposed mechanisms of miR-146a in alleviating experimental autoimmune anterior uveitis (EAAU) 6772 6775 7189 PMC5761609__F3 Activation signals of inflammasomes 114548 7099 3553 PMC5770815__F2 Kynurenic acid (KYNA)-mediated pathways of inflammatory signaling 2859 1499 6714 196 409 7124 3565 3659 3569 405 PMC5773092__F7 Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers 6469 3845 673 3265 4060 PMC5773247__F1 Wnt Signaling in Cardiovascular Disease: Opportunities and Challenges 4041 4040 6259 998 5879 2475 387 1499 7391 3725 860 4488 688 3565 PMC5777710__F13 CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NFKB/ iNOS pathway in STZ-induced diabetic mice 1017 4087 4088 50507 PMC5778882__F1 The Axl signaling pathway 2621 558 2885 6714 6774 63916 PMC5779007__F7 HIF‐1A strongly associates with differentially expressed genes in rAAA 650 3486 7873 57817 4015 2934 5054 7127 348 51129 7424 353322 4915 29923 1509 2353 10370 4092 2113 4088 10397 PMC5783456__F2 Ingenuity pathway analysis network identified with differential expressed genes 256309 64798 1119 10351 6097 259 1183 57016 10551 3170 1109 3169 359787 3171 4760 8644 3174 8431 5454 7089 26470 83758 5083 2018 10057 PMC5787447__F5 Current research on head and neck cancer-associated long noncoding RNAs 2498 652995 100124700 7855 2146 5728 999 7422 101927703 1499 PMC5787545__F1 Gut microbes on innate immune receptor 594857 7097 7099 10333 64127 58484 4295 3605 1356 4599 PMC5793760__F4 TGFB signaling pathways 4087 4088 4090 4086 4089 PMC5796892__F11 Schematic representations demonstrating the role LdISP2 in the modulation of host response 10747 5648 717 727 716 PMC5797605__F1 mTOR signaling during autophagy 7249 7248 64798 6009 7942 8408 PMC5798330__F2 Transcripts relating to the classical complement pathway are overabundant in subclinical and active TB 3569 718 713 10747 5648 721 720 710 1378 717 727 730 729 735 966 1380 8857 2209 PMC5801575__F5 Proposed biosynthetic pathways of Cat315+, Cat316+ and WFA+ aggrecan 1431 51083 5015 PMC5803867__F6 TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway 114548 9429 5174 7097 PMC5805723__F7 Oncogenic cooperation of BRAF V600E and TERT promoter mutations 2353 4609 7015 PMC5811474__F4 Illustration of E3 ligases and DUBs that regulate extrinsic pathway of Apoptosis 355 10298 9101 7186 83737 84231 331 8772 153769 8717 PMC5814291__F3 FOXC1, the new player in the cancer sandbox 1950 1956 5727 6608 5300 2296 2736 PMC5816931__F2 Recognition of Mycobacterium tuberculosis (Mtb) by Dectin-1 920 6850 64170 7124 10892 8915 324 PMC5823630__F6 Anti-estrogens mitigate mTORC1 inhibitor-induced activation of PI3K/AKT 3479 5163 3667 3480 3643 PMC5824027__F3 Hippo Pathway in Cancer Stem Cell Biology 6714 6010 9113 26524 324 9686 PMC5824497__F2 NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning 23475 93100 23411 51548 51547 10135 23057 22933 23410 23409 23408 203447 349565 952 PMC5825991__F2 Targeting pattern-recognition receptor signaling in human intestinal inflammation 54106 7096 7097 29110 6101 3656 PMC5827560__F1 A biological pathway regulating memory, synaptic plasticity and schizophrenia risk 2066 3084 4775 627 23237 1960 6722 4665 PMC5828202__F10 Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway 83939 468 6667 PMC5828651__F5 RNA-editing regulated genes in LUAD are enriched in apoptosis and innate immune-related genes 355 7124 1998 57506 1676 PMC5830368__F2 Current evidence for extracellular vesicle crosstalk in the homeostatic bone marrow microenvironment 9242 7412 7173 27329 23452 PMC5835590__F9 Summary of the main differences between NE high and low subtypes of SCLC 429 4609 5978 430 10413 7080 10683 4760 8788 PMC5835759__F1 Interactions among Protein Kinase C Alpha (PRKCA), NOS3, and BDKRB2 gene products within the ACE inhibitor pathway may affect the antihypertensive response to enalapril 1636 4313 7076 185 624 PMC5836190__F5 Alternative pathway of NLRP3 inflammasome activation 8737 8772 114548 PMC5837624__F1 Proposed mechanisms of cell injury induced by APOL1 variants 8542 91662 7099 114548 3553 PMC5839936__F3 Proteins significantly altered by torcetrapib associated with insulin sensitivity or pancreatic Beta-cell function 9370 348 948 10272 7040 2690 4313 2931 8742 5599 5588 207 PMC5841108__F11 Schematic representation of miR-34a regulating SIRT1/AMPKA signaling pathways and Egr1 involved in the HG-induced fibrosis and inflammation in RMCs 23411 1958 6374 PMC5846367__F2 Interplay between immune system and gut microbiota in homeostasis, tolerance, and inflammation 90865 85480 324 3458 920 7054 PMC5846707__F1 Signal transduction by TGFBs and BMPs TGFB and BMP ligands induce formation of heteromeric complex between specific Type II and Type I receptors 6010 3984 4089 29102 7018 PMC5849056__F1 Complement System and Preeclampsia 718 1604 1378 4179 727 717 730 729 966 735 5648 PMC5852877__F1 TLR4 intracellular signaling pathways 4615 114609 51135 3656 7187 7189 29110 257397 23118 8195 3661 PMC5855642__F2 Transformation of SphK/S1P/S1PRs signaling 8877 1903 1901 PMC5855671__F2 Integrins act as “double agents” during Helicobacter pylori infection in the stomach, serving to potentiate bacterial pathogenicity while also aiding in the immune response 51665 551 3611 1956 100187907 PMC5855695__F1 MicroRNA biosynthesis pathway 29102 54487 26523 192670 27161 192669 PMC5855797__F6 Signal transduction in relation to the IR 2693 5163 5728 3667 5164 PMC5858852__F7 Pathways enriched for genes associated with ovarian cancer 2731 25805 3294 64321 445 29968 23566 9945 7482 6422 316 6513 55790 126 11211 525 4316 2258 125 124975 216 339896 1164 2254 2122 PMC5864191__F2 Mevalonate pathway and mutp53 4598 9961 3301 10654 4597 2224 6010 PMC5864227__F1 Mutp53 accumulation in tumours is sustained by mechanical inputs through a mevalonate-RhoA-HDAC axis 387 10013 4193 PMC5868625__F6 Summary of the inhibitory effect of ILQ on PI3K/Akt/mTOR pathway members.Abbreviation: ILQ, isoliquiritigenin 5163 2475 2932 1499 595 PMC5870182__F6 Schematic diagram illustrating the mechanism of WYHZTL formula in regulating Wnt/Beta-catenin signaling pathway 2932 324 1499 595 100379198 PMC5872399__F5 The complexity of AM death Regulation following infection, trauma, and HS 3146 7099 4615 64127 PMC5875422__F8 Schematic shows the relationship between neuronal and oligodendrocyte metabolism 10215 7368 259230 443 339983 PMC5876656__F1 The Hippo signaling pathway is composed of neurofibromin 2 (NF2), mammalian STE20-like protein kinase 1/2 (Mst1/2) and large tumor suppressor 1/2 (Lats1/2) 4485 4771 9113 26524 PMC5879088__F1 Canonical leptin signaling in hypothalamic neurons 6649 50507 3717 6774 5443 181 PMC5879765__F4 Osteogenic differentiation through p38 MAPK signaling pathway 5879 594857 5008 10682 860 650 PMC5880173__F1 Bone morphogenetic protein (BMP) pathway and potential strategies for therapeutic modulation 4090 4086 4089 PMC5883082__F1 Programmed cell death protein 1 (PD-1) mediated intracellular signaling events during T cell activation 941 942 940 3932 2885 920 PMC5883129__F2 Activation of NEMO and IKB by multiple signaling pathways 7706 51135 7187 7189 5970 PMC5884027__F2 NRF2- and SIRT1-signaling pathways targeted by antioxidant compounds 3479 5728 2932 2309 23411 PMC5884123__F8 Schematic diagram demonstrates the proliferation and apoptosis pathways including the upstream and downstream cascades activated by VEGFC in the GC-1 cells 7424 2353 595 1958 PMC5884924__F9 White adipose tissue browning through reducing tenascin C inflammatory signaling 3371 7099 3202 114548 652 4086 PMC5890536__F9 RFc constructs on human complement 474387 717 720 1356 718 PMC5890889__F4 Proposed ferritin-mediated feed-forward inflammatory loop 54106 9332 3162 PMC5891173__F3 Aldo‐Keto reductase 1C2 (AKR1C2) expression in prostate cancer cell lines 1646 1586 3284 6715 PMC5892012__F1 TERT levels affect EBV latent/lytic status 7015 4853 10538 PMC5894198__F8 Schematic diagram of GDF15 activating the PI3K/AKT and MAPK pathway in cervical cancer progression 9518 2064 207 4609 1019 595 1017 898 PMC5900789__F1 IL-10-mediated modulation of myeloid cells 4615 7297 3716 574447 406947 406963 6772 6774 4286 10457 3661 602 4783 7018 9021 941 942 3135 3587 929 7099 PMC5903700__F6 Schematic diagram summarising the biological processes underlying the association of the 35‐gene expression signature with PTEN/AKT signalling pathways 5728 7169 2475 7178 72 PMC5910271__F2 Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases 23410 23411 9575 406 PMC5910288__F3 Interactions between cellular metabolism, the circadian molecular clock, and ion channels 9118 57716 406 9575 10135 23410 3550 PMC5920642__F3 Cell proliferation and negative apoptosis regulation in the uterine leiomyoma 3303 5594 3315 3320 2923 811 207 596 7415 3309 22926 PMC5922990__F9 Antiviral properties of naringenin 7436 3156 57762 5465 PMC5922992__F1 Nucleotide-binding oligomerization domain 1-mediated mucosal host defense against Helicobacter pylori infection 10392 7187 3665 4283 3576 3627 6373 PMC5923370__F3 Summary of discussed cancer-relevant pathways that activate YAP and TAZ 1956 1950 1499 558 652 9411 6714 6010 7039 PMC5923440__F1 MAMP/PAMP sensing pathways in the intestine 59307 4615 79671 64127 10392 57506 115004 3654 7189 7187 22900 3661 29110 10010 3665 834 3603 PMC5925168__F2 Pruritic signaling pathways 116512 5331 7442 8989 83737 PMC5932566__F2 Molecular and signaling impact of MUC5AC in various malignancies 3576 7422 4586 999 4316 1499 4314 1000 PMC5933896__F3 Signaling and regulatory network of gp120 at apoptosis pathway 6376 2358 2357 912 6506 3561 834 57506 596 7015 50507 3684 PMC5934344__F3 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy 7474 23002 9722 387 6093 PMC5938431__F3 Interferon regulatory factor 1 inactivation in human cancer 7297 3717 83990 1017 9636 4015 3661 PMC5940409__F7 Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells 3479 472 6774 595 PMC5951830__F7 Metabolism of bicarbonate and t6A37 formation in cytoplasm and mitochondria 768 79693 64172 PMC5952219__F2 TLR4 signaling pathway 3146 1896 3654 3656 7189 8737 29110 3661 3665 4615 4118 PMC5953846__F8 Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer 594857 4363 8772 581 9429 5243 PMC5954114__F1 GAS6 and representative TAM family receptor 2621 2717 1950 8205 PMC5954996__F7 BACTEROIDES FRAGILIS TOXIN COORDINATES A PRO-CARCINOGENIC INFLAMMATORY CASCADE VIA TARGETING OF COLONIC EPITHELIAL CELLS 6774 324 999 1499 PMC5955808__F1 Colorectal cancer prevention: immune modulation taking the stage 920 1493 324 3845 673 7157 1499 PMC5957297__F4 MAPK pathway bypass in melanoma 673 4286 367 PMC5962335__F4 Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration 952 10135 203447 93100 4860 23475 PMC5963017__F8 Pridopidine enhances cAMP/PKA and TrkB pathway genes in the YAC128 striatum 627 431704 2853 8446 2353 4478 PMC5964128__F3 Dex represses expression of phagosome formation-associated genes 7448 2335 4049 6850 6010 4082 64581 PMC5968105__F1 Senescence-associated secretory phenotype (SASP) is regulated by an interactive network of pathways that dictate its functional outcome 2920 2919 2475 472 4851 10682 PMC5974248__F3 Involvement of optineurin in nuclear factor kappa B (NFKB) signaling 4615 3654 51135 10133 7189 29110 3661 3665 PMC5983187__F4 Intracellular signaling pathways arising from B common (Bc) receptor activation 3716 4067 3717 204 PMC5983574__F1 Invasion-related molecules in oral squamous cell carcinoma 1000 2260 999 1830 4313 3082 51083 1956 4283 2833 PMC5983605__F2 Diagram of WNT (Wingless-type) signaling pathway 4040 4041 100187761 324 2932 1499 PMC5988709__F1 NNMT links NAD+ and methionine metabolism 27232 10135 4837 2593 10400 635 PMC5992185__F1 Regulation of the TGFB/Smad signaling pathway by Ski and SnoN 4088 4087 4089 6498 6497 4092 PMC5996447__F8 Hei-Gu-Teng Zhuifenghuoluo granule and the IL-12 signaling pathway 3594 6775 3603 3553 4280 PMC5997150__F2 Requirement of the Arf6-based mesenchymal pathway in both mesenchymal-type and amoeboid-type cancer invasion 1950 3082 4018 382 6935 57669 387 5879 PMC5997167__F3 Gene networks involved in the analyses of males with HCB exposure 2717 65057 79923 7703 PMC5998742__F1 Toll-like receptor (TLR) 4 signaling pathway 7099 4615 51135 3654 7189 7187 3661 PMC6001649__F2 Salivary Exosomes: Emerging Roles in Systemic Disease 5728 27250 5688 PMC6001654__F1 Role of DKK4 in different signal pathway 7421 27121 5595 1499 2932 960 595 PMC6004076__F3 Mitotic errors can trigger activation of p53 472 26524 4193 835 PMC6004386__F1 Binding of S100A8/A9 to toll-like receptor (TLR) 4 triggers the MyD88-dependent pathway, appearing to play a vital role in inflammation 6279 6280 7099 4615 7189 PMC6004600__F2 Innate immune receptors drive dengue virus immune activation and disease 6850 4615 57506 29110 7124 3553 6347 6348 6351 4046 PMC6008335__F1 Synthetic biology-inspired genetic circuits for caffeine-induced gene expression 6778 3597 6774 2002 PMC6010716__F3 Genes predicted to increase cardiovascular angiogenesis are strongly up‐regulated by CpG pre‐conditioning 24 h post‐I/R 634 83737 3689 3684 6418 629 PMC6013556__F1 Pathway activation after damage-associated molecular patterns (DAMPs) stimulation 3146 7099 929 4615 51135 3654 PMC6015534__F1 Schematic describes the major developmental steps that underlie the differentiation of preskeletal mesenchymal cells toward endochondral (right) and intramembranous (left) ossification 6662 6660 55553 860 864 4208 4209 468 PMC6016889__F1 CLL main pathogenic pathways and target agents against BTK, PI3K and Bcl-2 6387 930 4919 613 4851 4920 7852 958 387 4067 6850 695 5336 2475 PMC6017900__F7 Signaling pathways for flaccidoxide-13-acetate in bladder cancer 2885 387 2475 4313 PMC6019445__F1 Schematic describing invariant natural killer T (iNKT) cell development and function in the thymus 100133941 1959 969 912 920 2625 6361 6367 326 7006 100124696 PMC6019726__F1 Production of IL-32 and its downstream signaling network 9235 3553 10392 64127 PMC6021929__F5 Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants 6836 7874 2056 10336 5646 339105 2243 28 57153 2153 PMC6027159__F7 TNF-R1 signaling pathway 7124 83737 8887 8717 7186 9825 90268 1540 10454 23118 257397 81858 PMC6027159__F9 Nod1/2 signaling pathway 64127 8767 331 10454 23118 257397 81858 PMC6027159__F10 RIG-I/MAVS signaling pathway 7706 10454 23118 257397 57506 11074 7188 7186 7189 81858 PMC6027295__F1 Main signaling pathways of adiponectin in healthy liver 51094 79602 5465 PMC6027307__F1 Noncanonical NFKB signaling pathway 958 7187 7186 5971 PMC6027339__F2 Chronic active BCR signaling in lymphoid malignancies 613 6850 4067 5336 29760 695 974 973 930 PMC6028070__F1 Cytokine signaling and their major negative regulators 7124 3716 8717 7186 8772 PMC6029413__F2 Multiple roles of the extracellular matrix (ECM) in modulating the cancer-immunity cycle 1462 1236 325 PMC6029485__F2 IGF signaling pathway in pulmonary fibrosis 3479 1958 1959 2353 PMC6031874__F1 Simplified scheme of transsulfuration pathway 4397 5212 4524 875 51380 847 4357 PMC6032036__F4 Ingenuity pathway analysis of ALX4 genes and antidepressant genes based on treatment response in MDD 66002 60529 64405 1571 1559 1499 51176 3356 1581 1588 4609 113612 2132 1312 627 3568 5340 6532 8522 7166 2824 PMC6032287__F1 Phoenixin-20 stimulates the mRNA expression of GnRH, GnRH receptor, Kiss1 peptide, and GRP173 via the cAMP-PKA pathway and CREB phosphorylation mediated by the GPR173 2798 10682 54328 3814 PMC6032341__F3 ATM-dependent DNA Damage Response 10048 472 10524 PMC6042708__F14 Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells 5211 5223 5160 PMC6043822__F6 The main modulated genes and their reciprocal interactions in the cell 5118 7040 2520 22822 5732 3161 249 50486 4088 890 1306 54361 7057 1301 650 26577 7412 2318 2317 1266 1827 3875 9133 PMC6044387__F5 The two co-occurring pathways in PDAC that are predicted to drive oncogenesis based on the mutational landscape representing two common driver pathways 6418 3845 5290 57521 2033 4193 1029 894 4609 4194 1030 1021 472 672 5925 2065 5728 2309 2066 7249 7248 2475 5295 5156 841 596 5159 673 2353 10216 23349 5266 PMC6045629__F9 Mechanism of coagonism 3932 27040 3702 7535 PMC6048025__F8 Regulatory effects of androgen on TGFB1/Smad signaling pathway and Nrf2-ARE signaling pathway 9817 847 4313 7077 7045 1728 PMC6052836__F1 The regulation of the anti-viral signaling pathway 115004 3428 9447 54106 7098 51284 7187 7189 4615 3661 5300 5728 3665 PMC6056002__F2 Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression 6010 5879 10298 10135 1499 952 3586 PMC6058063__F1 Immunoglobulin G4-related disease (IgG4-RD) and immune pathways to therapy. Naïve B cells are activated by exposure to antigens 613 3586 59067 50615 958 930 941 939 952 920 PMC6058517__F1 Schematic representation of the rough PTX-PLGA-MS fabrication technique, tumor site injection and intracellular drug delivery pathway 4397 891 595 PMC6060254__F1 lncRNAs involved in the IFN antiviral response 3717 7297 3716 115004 4599 684 2537 2633 100506668 105221694 100126791 4938 3434 8519 7098 51284 4615 29110 10379 104326052 9636 10410 8638 91543 129607 100506895 3665 283131 3661 11274 57506 PMC6060409__F2 Innate immune response to RSV: Advances in our understanding of critical viral and host factors 4615 57762 57506 10379 7099 7097 10333 6772 PMC6061846__F8 Signalling pathway that mediates TRPA1-dependent PMA induced by GTN 217 27035 8989 PMC6065152__F2 Pancreatic cancer microenvironment participates in metastasis 8205 100653366 5155 2919 3576 4015 1524 5768 6469 7099 6774 PMC6065367__F8 Proposed mechanism for TSPO ligand-induced ATP release 706 222642 100187761 PMC6071023__F2 Resistance to EGFR tyrosine kinase inhibitors 1950 1956 7477 6608 3845 7249 7248 2627 6009 2475 PMC6071523__F8 Schematic illustration of the crosstalk between CAFs and cancer cells in the tumor microenvironment 283120 1499 8205 PMC6073374__F1 Mechanistic target of rapamycin (mTOR) signaling pathway 2308 2309 4303 100132074 64798 1977 57521 PMC6074780__F1 PD-1 in T-cell activation, exhaustion and effector function.Notes: (A) T-cells are activated via (1) binding of MHC plus peptide on an APC to the TCR and then (2) binding of APC CD80/86 to T-cell CD28 324 940 941 942 PMC6089846__F3 Rubone and the p53 pathway 4193 581 51176 960 1499 PMC6089846__F5 Relationship between AR translocation and the AKT signaling pathway 5728 367 7249 7248 3725 6009 2289 2475 PMC6089847__F2 Pathways of T-cell inactivation and mechanisms of monoclonal antibodies 941 942 1493 201633 84868 PMC6096743__F5 Relationship between individual genes composing the ‘blood vessel development’ ontology group 7026 859 7857 3910 2324 54538 7424 51705 7057 1003 6387 1901 57125 960 7049 2004 4223 5396 51162 7070 10052 641700 7127 PMC6097464__F9 Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set 7057 3909 3918 25805 3915 3685 7124 4049 10468 7374 3681 2812 PMC6102046__F6 CNPY2 is a Key Initiator of the PERK-CHOP Pathway of the Unfolded Protein Response 10330 83939 468 PMC6102368__F5 VEGF and Notch interaction in physiological and tumor angiogenesis 4851 4854 8829 4853 2260 2249 7412 PMC6105693__F8 Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis 2214 3119 283420 3507 972 3683 6352 246 3937 10499 7412 121599 91937 PMC6105724__F6 Neuropathology following treatment with NP03-lithium 1499 6774 83939 2932 2475 2670 4040 PMC6107220__F1 Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies 196743 54498 6723 6611 PMC6108178__F3 Primary myelofibrosis based on results obtained in animal models 7173 3717 4352 PMC6108877__F7 Schematic representation of the anti-invasive effects of wogonin in LPS-stimulated MDA-MB-231 cells, via the 5-LO/BLT2 pathway 7099 4615 4050 PMC6116613__F3 MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE 4976 26291 468 PMC6117460__F1 A Retinoic Acid Signaling Pathway to Promote ProliferationRetinoic acid, acting via HIF1A and VEGF, is necessary for S-phase re-entry of NSPCs 3091 1021 1019 7422 PMC6119098__F4 E-cadherin in Contact Inhibition and Cancer 999 1499 2932 324 PMC6119347__F2 Network created by Ingenuity Pathway Analysis using the top 36 most highly connected genes disrupted by rolandic epilepsy (RE) CNVs as assessed by the Disease Association Protein-Protein Link Evaluator 8748 165545 53616 368 2894 2066 1740 26275 84435 10718 145957 221692 23410 168002 1634 7082 954 3725 145864 84623 6772 32 3551 56999 3645 55728 25946 408050 134728 135644 339451 PMC6120695__F2 Secreted immunomodulatory factors transcriptionally induced by oncogenic Kras signaling 3845 2919 6374 2920 3576 PMC6120695__F3 Cooperation of Kras-mutant tumor cells with pancreatic stellate cells in tumor microenvironment (TME) immunomodulation 3845 3569 6774 3627 6387 PMC6121402__F1 Mammalian target of rapamycin (mTOR) pathway 3667 7249 7248 51256 6009 PMC6125217__F1 Nodal and Shh Signaling 4838 6997 4087 4088 4089 8928 6469 84976 5727 6608 2737 2736 91653 2619 50937 PMC6125328__F4 CARMA/CARD-dependent and-independent MALT1 activation 10892 29851 1493 613 940 5335 5336 8915 PMC6128084__F6 Cellular metabolism for heme synthesis during early and late erythropoiesis 54977 6510 1356 212 79751 211 PMC6129509__F10 Pi3k-akt signaling pathway interactions 1017 1019 898 672 3915 1282 2256 PMC6131564__F2 Sub-pathway of the MAPK signaling pathway identified on the basis of sub-pathway strategy 5609 5596 4342 6416 5604 4214 2353 5606 401288 81571 PMC6131589__F1 Sights and mechanisms of mHTT toxicity in yeast models of HD 3064 718 8564 PMC6134795__F1 Composite pathway using the KEGG pathway analysis, a composite pathway was generated based on the canonical mapping of the phosphorylated proteins independently associated with increased % collagen (red) in the liver 355 1616 7186 3984 3985 PMC6135256__F4 The effects of NBUVB on the bulge and epidermis of human vitiligo skin during repigmentation 7057 3371 6662 10804 8324 2735 1499 6422 6615 10642 PMC6135632__F10 The signaling pathway regulating RAB26-induced SRC degradation (a) Under normal physiological conditions, RAB26 interacts with ATG16L1, resulting in the induction of autophagy, which targets phosphorylated SRC for degradation 25837 55054 1003 6714 PMC6135677__F7 Sketch diagram illustrated the target genes by the selected miRNAs in ROS-AKT-cyclinsenescence pathway 207 208 10000 2932 894 1019 1017 PMC6138560__F2 Immunobiology of Ubiquitin-Dependent B Cell Receptor Functions 6850 83737 867 PMC6139543__F11 Proposed alternative metabolic/antidotal pathway of atRAL in the retina 9227 6120 6121 PMC6144927__F1 TGFB signaling maintains homeostasis between the proliferation and apoptosis of normal epithelial cells by Smads or other Smad-independent downstream pathways 4089 4087 4088 4609 1601 4318 999 PMC6148080__F20 Differential trafficking of somatostatin receptors 6750 5481 5478 9360 PMC6148804__F1 Pictorial representation of un-inhibited Avian avulavirus 1 (APMV-1)-induced type I interferon (IFN) response in waterfowl cells 7297 10379 57506 6773 3661 PMC6152668__F3 DET- and IDET-induced apoptosis in different cancer cell lines 2475 355 8772 637 581 PMC6158396__F3 HMGB1 signaling pathway in cerebrovascular disease 3146 7097 3553 3383 PMC6163404__F1 Brief overview of canonical and non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) activation pathways 7124 5970 5971 PMC6164146__F2 Activation and Attenuation of IL-33/ST2 Signaling 6761 90865 59307 4615 51135 7189 3654 PMC6164406__F1 Toll-like receptor (TLR) 4 signaling pathway 7099 4615 114609 7189 7187 8195 3661 PMC6166407__F1 Pro-tumorigenic functions of GPNMB 6714 102 1956 11319 10457 8829 PMC6172067__F5 Prognostic biomarkers in clear cell renal carcinoma 4915 7431 948 6688 356 7422 3702 PMC6176931__F3 Multiple phases and regulation of cilium assembly 4218 9101 81565 10938 146057 57787 79734 56623 PMC6177508__F1 Schematic model for phosphorylation-dependent YAP translocation by DVL 26524 999 1499 PMC6182840__F1 The sorting mechanism of exosomal miRNA MiRNA genes are transcribed into primary miRNAs (pri-miRNA) by Pol-II 94121 29102 27161 23086 PMC6186432__F2 Apoptotic membrane blebbing through DR5/Casp-3/ROCK1 signaling pathway 8772 3985 4638 PMC6195737__F2 IGF signaling in the placenta 3479 3481 3486 596 PMC6201246__F6 Overview of current understanding of the pathogenesis of HIT 5196 718 7450 8178 PMC6202151__F7 Schematic depiction of proposal mechanism by which AF confers anticancer actions in TamR breast cancer cells 3655 3691 6714 581 PMC6202673__F1 Proposed model of airway tolerance 7099 90865 64806 6364 3662 PMC6205057__F8 The Potential Schematic Diagram of the Effects of CPE on the Beta Cell and Liver Tissue 3553 5465 51085 6720 7038 PMC6206158__F1 Complement activation pathway and regulation 720 5648 10747 716 718 721 2271 1378 4179 729 966 PMC6206761__F2 Interconnected responsible pathways to cause amyloid and tau accumulation 348 1191 10347 1378 8301 945 23607 54209 274 2041 PMC6208163__F2 Roles of NRF2 in Modulating Cellular Iron Homeostasis 2235 10058 4094 PMC6214712__F1 Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Cell Phenotypes 6657 9314 8433 861 3169 2623 2626 860 6046 23476 4204 1108 100653366 2300 3516 3298 10664 1786 PMC6215106__F7 Autophagy in response to the Zearalenone–induced G2/M cell cycle arrest 2475 994 891 PMC6219204__F2 Crosstalk of FGF10 during pancreatic cancer 2255 2252 3845 1956 4772 6662 133 PMC6221947__F1 Polyamine Pathway and Reaction Mechanism of DHS 1984 83475 100187761 1611 PMC6224991__F1 Axels and brakes in the immune reaction 940 7535 1493 PMC6235699__F2 NAD+ and sirtuins in retinal degenerative diseases: a look at future therapies 10135 64802 349565 23057 PMC6235775__F4 Intracellular calcium regulates muscle atrophy via calpain regulated Ub-proteasome pathway and apoptosis 759 847 581 PMC6237576__F4 Contributions of PCAF‐induced acetylation to the development of hepatocellular carcinoma and liver cancer tumour growth 2597 2735 5728 619501 581 2475 5315 PMC6241696__F4 Regulatory network of FSH to cervical cancer 2492 2932 836 PMC6242766__F2 Animal Models to Study Bile Acid Metabolism 1593 9420 1582 8205 PMC6249341__F1 Implication of microglia in the development of Alzheimer's disease 351 54209 945 7099 367 114548 348 3553 PMC6250734__F8 Diagrammatic sketch of molecular mechanism 84740 324 1499 PMC6250852__F1 Oxidative stress and activation of Cerebrovascular Endothelial Cells 7412 3383 387 7099 4615 3553 1003 PMC6251962__F1 Innate immunity and adaptive immunity 54106 7097 64806 85480 90865 3576 PMC6256264__F7 Schematic summary of molecular mechanisms for duhuo jisheng decoction (DHJSD) on the lower back pain (LBP) caused by Bi Zheng 1499 6010 4088 3725 7852 8139 PMC6256358__F1 Tankyrase function in cancer 5728 154796 5426 PMC6260778__F5 Microenvironment recruits Tregs to tumor tissue by chemotaxis 6364 56477 6387 2826 7852 1235 50943 PMC6262299__F2 Neurotrophic factor (NTFs) signaling pathways 1270 4803 627 2668 5979 572 PMC6267225__F2 Core analyses network predictions for HBoV-infected CuFi-8 cells 2308 64332 10736 8398 4092 7057 9590 9181 710 26504 4739 3707 6137 23327 PMC6269289__F1 A simplified diagram of sialic acid metabolism in human 10020 54187 140838 26503 55907 10559 PMC6271612__F1 The molecular mechanism behind mitophagy after stroke 55669 9927 664 PMC6274717__F2 IL-6 signal transduction and modes of the IL-6 receptor system 8651 6772 6774 9021 10865 PMC6274856__F1 Cartoon showing the major signaling pathways targeted by phytochemicals in cancer 5728 2475 1975 5894 PMC6274979__F1 The activation of Yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) in epithelial cells and fibroblasts 558 374 595 332 598 PMC6275186__F2 Representative image of the participation of SARA in the TGFB signaling pathway 8411 4092 5480 PMC6275466__F3 NOTCH signaling in B cell development 4853 10113 4851 PMC6277408__F4 Analysis of p53-pathway in relation to miRNA expression and potential targets 581 842 331 836 PMC6278438__F4 pathway of miRNA processing to regulate mRNA decay 54487 29102 27161 9656 PMC6279509__F9 Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels 1499 650 860 4313 4318 PMC6279860__F2 PD-L1/PD-1 signaling pathway and the correlated network 10538 7018 7535 3932 940 1956 1950 PMC6280699__F8 Proinflammatory and anti-inflammatory effects of IFNB in CF: (A) IFNB triggers JAK/STATsignaling pathway activation (STAT1, STAT3, and STAT3 proteins) 6773 6774 6772 PMC6281172__F2 IFN-JAK-STAT signaling pathway 3455 3454 3716 7297 6773 10379 6772 23476 6046 9282 PMC6283435__F3 TF cascades under glucagon control 7528 7942 1958 28999 PMC6286919__F1 Schematic representation illustrating the signaling molecules that regulate the PD-1/PD-L1 transcription 324 941 942 940 5728 6774 3716 PMC6287147__F8 Schematic illustration of a working model for the TGFB1/SMAD/Snail pathway in modulation of EMT-dependent fibrosis in SGEC 4087 4088 4089 999 PMC6288499__F1 Epidermal growth factor receptor pathway in patients with wild-type and mutant BRAF and KRAS 1956 3845 673 PMC6289345__F5 The proposed metabolic pathway of cryptotanshinone in HLMs 1557 1548 1576 1544 7364 7363 54600 PMC6289701__F2 Mammalian mTORC1-dependent ribosomal transcription 257218 11201 2475 1108 4094 PMC6290922__F5 T-bet: a bridge between innate and adaptive immunity 10219 8320 1236 6775 5163 3458 604 2308 3002 2475 864 2833 1232 643 920 7054 PMC6292306__F2 Serotonin directly increases PTHrP synthesis in the mammary gland and indirectly through regulation of the Hedgehog signaling pathway 84876 846 6469 PMC6297255__F8 Model proposing ROCK inhibition mediates morphological shift and neurite outgrowth-promoting property of OECs 387 3897 7046 7048 PMC6299398__F5 Affected pathways in group 4 medulloblastoma 6469 442213 94025 5101 6608 51684 2932 1499 2735 2737 2736 PMC6300493__F6 E3 ligases regulate breast cancer cell proliferation 22866 83737 23558 57154 11059 154796 64750 4040 4041 PMC6305110__F1 Promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy 325 942 941 3902 11148 PMC6305530__F1 Hepatitis C virus-induced inflammation 114548 7097 51311 7099 7098 51284 4615 3603 PMC6306791__F8 Possible molecular targets of the preventive effects of PT in Cr(VI)-induced ACD 114548 3553 65057 PMC6307166__F4 CircRNA-miRNA interactions are potentially involved in the initiation and progression of CRC 1956 407047 3667 324 27250 1788 5290 10253 6935 5266 PMC6310057__F1 Potential targets of glucose metabolism for anticancer therapy 2539 2597 3939 PMC6311529__F7 Proposed model of LUBAC-mediated ubiquitination on cFLIP in the TNFA receptor signaling pathway 8737 8717 8772 7186 7188 81858 55072 PMC6315366__F4 Autophagy, Keap1 and p62 regulate Nrf2 in HCC 8408 29110 2475 9817 PMC6315738__F1 Intestinal uptake of non-heme iron and its regulation 9843 2242 5093 759 PMC6316648__F3 Major mechanisms for hepcidin regulation 151176 654 650 7018 148738 3716 3717 7036 6774 4086 4089 57817 3077 164656 PMC6316701__F2 Effect of SUMO on IFN pathways 6772 619537 3661 6612 PMC6319021__F5 Proposed mechanism for kCer acting as a Sema3A-like ligand 10371 8829 2534 5879 3984 PMC6320700__F1 Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era 1674 253782 29956 204219 10715 79603 91012 PMC6322405__F1 Hippo signaling network and its biological functions 8473 6714 7871 PMC6323259__F4 Schematic presentation of the proposed effects of melatonin against ANIT-induced intrahepatic cholestasis 2729 2730 9817 PMC6326012__F1 The metabolic pathway for vitamin D (Adapted/modified from Schlingmann et al 120227 1591 5741 1594 8074 PMC6326993__F2 Schematic overview on a striatal medium spiny neuron synapse 7054 111 2774 2775 10846 PMC6327307__F3 Epigenetic control of CD8+ T cell differentiation 9055 2308 10219 1029 8650 55294 7018 23476 10538 23411 PMC6328617__F1 CD44v6 engages in colorectal cancer progression 4313 960 4318 1499 4088 6714 PMC6328617__F3 CD44v6 engages in colorectal cancer progression 960 6387 1950 3082 1956 7852 1499 PMC6329944__F1 Three phases of tooth eruption, preeruptive, intraosseous, and supraosseous, require signaling in the PTHrP/PTH1R pathway 1435 100187761 5745 4280 PMC6332483__F6 Schematic model of SNHG6 in CRC cells 641638 6935 5976 PMC6335096__F5 Three mechanisms of pexophagy in mammalian cells 4077 5828 5193 5192 5830 472 6009 7249 7248 8408 55670 5190 5189 PMC6336016__F2 Application of built-in adjuvants for epitope-based vaccines 7100 7099 7096 10333 7097 54106 4615 4118 51284 3661 7098 PMC6340935__F1 The hexosamine biosynthetic pathway (HBP) leads to UDP-GlcNAc formation and regulates O-GlcNAcylation 8255 8473 10724 PMC6342515__F1 Therapeutic potential of NAD-boosting molecules: the in vivo evidence 952 9390 160728 120103 8140 10135 93100 23098 23057 23475 65220 50507 349565 4118 64802 PMC6343466__F1 The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis 3718 3716 3717 7084 7297 PMC6343712__F6 miR-300 mediates the SP1/MMP9 pathway in BCa 8788 1735 4318 100126297 6667 PMC6345546__F1 Mechanisms of translation initiation currently known 1977 1999 8664 79051 PMC6345911__F7 Postulated mechanism for ceramide dependent regulation of G-CSF signaling in BMCs 29956 2920 3579 4067 3717 6774 PMC6346552__F9 Proposed molecular model of non-coding RNAs involved in CXCL12/CXCR4-induced CRC invasion and progression 6387 7852 7503 6010 PMC6347283__F1 Representation of signaling pathways upstream of MTORC1 3667 5728 54541 7248 7249 51256 10670 5594 5603 5595 64121 6009 PMC6347506__F4 Integrative regulation of physiology by histone deacetylase 3 51043 8841 2874 79718 6907 718 7018 7040 90525 PMC6347688__F1 Social rank on blood cell gene expression and regulation vary by species and treatment according to two new studies in PNAS (, ) 2638 4615 3661 3665 7099 PMC6348509__F1 Targeting LCSCs by suppression of autophagy and Nanog.Autophagy positively regulated LCSCs by suppressing p53 and favoring the activity of Nanog 7099 79923 100133941 7291 6774 3082 5243 9429 8650 3383 6790 PMC6349770__F2 Implementation of metabolic engineering strategies in S 7498 2597 100187761 PMC6350063__F1 Understanding the Role of Antiviral Cytokines and Chemokines on Neural Stem/Progenitor Cell Activity and Survival 3976 3977 3280 6774 595 836 PMC6351746__F1 Biochemical pathways of R 718 4170 727 100233226 57817 PMC6352437__F8 Schematic diagram on the molecular mechanism of the anti-adipogenic effect of 10-HDA in 3 T3-L1 preadipocytes 7038 2167 10682 9370 4023 PMC6357196__F5 Proposed chemoresistance mechanism mediated by RAB7A 967 7879 3916 975 928 1040 PMC6361815__F1 Different types of GSLs 127550 53947 84002 7357 9331 2583 PMC6365711__F10 miRNA-223 may be an anticancer gene in NSCLC through the PI3K/AKT pathway by targeting EGFR 1956 595 581 PMC6365902__F1 B-cell receptor pathway, which may be dysregulated in TNBC 971 6850 613 4067 29760 695 2885 8915 930 PMC6366666__F1 TRAIL pathway targeting therapeutics 8772 637 581 PMC6367540__F4 Figure illustrates the signal transduction cascades of TGF/BMP, Wnt, Hedgehog signaling pathway in the development of cranial sutures 374654 6608 50846 3549 6469 5727 4090 4086 2736 2737 2735 1499 PMC6372909__F1 Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer 685 2069 1839 7039 1950 374 3273 2475 PMC6374915__F1 Different forms of programmed cell death and associated cascades 7124 2353 581 114548 8737 317 837 834 81030 8772 842 838 836 11035 841 840 197259 PMC6375548__F1 Alternative (backdoor) androgen production and masculinization in the human fetus 6715 3283 1646 8644 6716 8630 1586 3293 1645 1109 3294 1583 PMC6379280__F2 Rationale for choosing Arl13b, SMO, and melanin-concentrating hormone receptor 1 (MCHR1) as cilia-targeting moieties 2847 6608 200894 6469 5727 PMC6383653__F6 Signaling pathway activated by OxPAPC 2534 6714 1003 5879 5058 7507 PMC6385430__F8 Suppression of WNT2 in signaling pathway 100507632 7472 4041 1499 581 2932 PMC6385449__F13 miR-506 inhibited the expression of LHX2, which hampered TCF4 expression and inactivated the Wnt/Beta-catenin signaling pathway, consequently inhibiting tumor growth and metastasis in NPC 9355 1499 6925 999 PMC6386986__F5 CRPC development 367 100187761 10512 596 3169 PMC6390244__F4 Target-pathway network analyses results 4151 5569 7124 4129 4975 6531 5743 2891 2555 2554 150 152 1129 147 154 153 146 148 1131 6331 4048 6530 PMC6391454__F4 Graphic image representation of the possible mechanisms of lung inflammation in COPD involving purinergic signaling pathway 5167 84890 100 953 956 954 260431 PMC6393348__F2 Activated STAT3/5 signaling pathway by IL-6 receptor, Prolactin (PRL) receptor, VEGF Receptor, EGF Receptor, and IL-10 receptor 1950 5617 5618 1956 3717 6774 PMC6393639__F6 Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer 896 1021 1019 PMC6397541__F7 AhR−AREG axis defines a signaling pathway between cellular intrinsic redox mechanisms and surrounding TME 2919 6374 6347 196 2920 1956 6352 374 8205 7422 PMC6399501__F1 Disorders resulting from mutational defects in the SL synthesis pathway for ceramide and GSLs and the nonlysosomal SL degradation pathway 10558 9517 94103 2531 10715 8879 204219 55331 7357 8869 2583 PMC6405444__F2 Major pathways converging on uncontrolled growth in Drosophila epithelial cells 3535 23513 4312 4609 PMC6406032__F2 Scheme summarizing the role of TRP channels in cardiac fibrosis 7222 7225 54822 162514 59341 140803 7442 387 7220 7223 51393 PMC6407099__F3 Role of Itch in canonical Hh pathway 83737 2735 8650 717 6608 5727 51684 2737 PMC6407861__F1 Assembling a protective shield 55183 149840 112441434 4200 672 54537 PMC6408950__F1 RBP-J functions as a key negative regulator of osteoclastogenesis and inflammatory bone resorption 5336 4772 7124 PMC6411465__F9 A schematic diagram illustrating the proposed mechanism of AR‐CD44‐SOX2 signaling 960 367 6657 PMC6412296__F1 Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention 4170 8772 581 637 331 PMC6412864__F2 Crosstalk between UPR and autophagy 3920 3916 27074 7494 83939 468 PMC6423002__F1 AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency 79923 11166 6657 2475 8408 PMC6426753__F1 Complement pathways 718 717 716 3426 1378 3075 727 1431 PMC6428526__F3 EMT is Modulated by Multiple Cascades Through Several Networks 6935 1000 9739 23411 999 PMC6429113__F8 Proposed model for role of MARK4 in regulating lipogenesis in pig placental trophoblast cells 57787 22943 1499 5467 PMC6429987__F2 AMPK-mTOR signaling pathways during Mtb infection 345611 64127 8408 2475 7942 PMC6430635__F4 Different subcellular sources of MHC-I molecules for cross-presentation 8766 10067 972 PMC6430635__F5 Convergence of three vesicular pathways of endocytic traffic on the cross-presentation compartment in dendritic cells 8773 4615 8766 5879 9554 5873 PMC6430781__F5 Sub-network of the innate signaling pathway obtained after IPA analysis of the differentially expressed genes in A549 lung epithelial cells infected with WM 06.482 conidia 613 5971 3726 94005 7975 7538 1431 23764 PMC6433688__F11 Illustration of the FGF16 signalling pathway to regulate Leydig cell development 8823 207 208 PMC6435963__F2 Regulation of complement activation by RCAs or parasite-expressed proteins targeting different complement components at the different steps of complement activation 5648 1378 727 7448 966 1356 PMC6441107__F7 Proposed diagram for miRs-449 regulation in doxorubicin sensitivity and resistance cells 1021 1019 1869 5925 993 1017 9134 PMC6442998__F6 Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition 6421 5139 167410 3815 PMC6443908__F7 APR signaling pathway is associated with ozone exposure and bacterial infection 6929 6925 350 2002 57817 259 197 PMC6444272__F2 Herb-compound-target-signaling pathway network of BSJPD 5728 7157 581 7054 7422 PMC6444510__F1 cGAS-STING pathway 115004 29110 3661 377 PMC6447849__F1 Biogenesis of miRNA 29102 54487 27161 11201 PMC6454697__F4 miRNAs and Hippo pathway 4485 9113 26524 29102 54487 PMC6456454__F1 Inflammatory mediatorsA: Inflammatory mediators with mainly proatherogenic effects are mediated by interleukin-1(IL-1), interleukin-6 (IL-6), and tumor necrosis factorA (TNFA) through nuclear factor kappa beta (NFDB) signaling cascade 7124 5806 1401 PMC6460856__F3 MyD88 played a critical role in alveolar macrophage-mediated inflammatory response to CNTs 4615 7189 3553 PMC6461947__F6 Current understanding of SHON and ERA signalling 4087 4088 8205 4089 6667 PMC6462526__F6 5′-IT treatment affects intra-/extracellular adenosine balance and INSM1 expression leading to NB tumor cell death 132 100 3642 2932 1499 595 PMC6465568__F2 Signal crosstalk in NFKB transcriptional regulation 7124 4615 3661 3456 PMC6465591__F1 Lymphatic vessel functions during tumor progression 7424 6366 6387 7852 1236 7412 920 PMC6467343__F1 Complications and management of coagulation disorders in leukemia patients 7035 5340 1431 2224 PMC6468702__F3 Sub-genomic flavivirus RNAs (sfRNAs) impair cellular response to viral infection 9908 7706 10146 54464 PMC6468754__F1 Hypoxia inducible factor (HIF) and vascular endothelial growth factor (VEGF) link the angiogenesis signaling pathways 8205 7412 3383 PMC6469018__F3 Signaling pathway of different DCs receptors (CLRs) 6850 64170 8915 10892 PMC6470603__F8 Compound 3f exerted anti-pulmonary fibrosis activity via repression of the TGFB/Smad signaling pathway 4087 4088 1281 PMC6470667__F1 IL-1, IL-36, IL-37, and IL-38 receptors and intracellular signaling 27179 27177 3553 3554 11141 4615 51135 3654 4088 7189 PMC6471792__F3 Hypothetical G protein-coupled receptor (GPCR) heterodimeric T1R2/T1R3 taste receptors exist in a multimeric receptor complex with NMBR, IRB, and Neu-1 in naïve IR expressing cells 4829 10682 4758 4318 3667 PMC6476316__F4 Mutations in the bone morphogenetic protein-signaling pathway are linked to hereditary hemorrhagic telangiectasia and pulmonary artery hypertension 2022 659 94 4093 4089 29102 PMC6476693__F1 Metabolic profiles influence macrophage inflammatory status 3566 948 6778 6774 5465 PMC6476855__F1 Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation 627 4615 6714 1950 2475 PMC6477784__F3 The interplay between purinergic signaling and ComC activation during mobilization of HSPCs 5330 727 3146 6280 PMC6480560__F1 Transcriptional changes of type I interferon (IFN-I) signaling pathway members in the cerebellum of canine distemper virus (CDV)-infected compared to control dogs 7297 3716 3659 6772 10379 3661 6773 3663 7098 3665 51284 9636 4938 4599 4939 4615 4600 8638 100187761 PMC6488436__F1 Sphingolipid metabolism 2581 6611 64781 10715 253782 91012 204219 29956 79603 1674 PMC6492315__F4 Schematic overview for the roles of miR-24, miR-23a and miR-145 in TGFB signaling in AKI 317 7046 7048 841 4087 840 836 4088 4089 5340 6667 2309 PMC6492945__F9 Schematic mechanism of Mac-1 regulation of human FOXP1 gene promoters and expression 9759 3654 7189 100506815 PMC6493850__F2 Putative mechanisms underlying the neuroprotective effects of TGF‐B1 against AB‐induced neurodegeneration 22943 4040 4041 2932 1499 PMC6497508__F2 Role of the classical and terminal complement pathways in cold agglutinin disease and target levels of complement inhibitors 717 718 727 PMC6503977__F7 Proposed Shh-Foxd1-Cdkn1c signaling model 6469 6608 5727 595 1019 1028 2297 2735 2736 PMC6505627__F2 BCR: a promiscuous fusion partner in hematopoietic disorders 613 2260 5979 3717 5156 PMC6514093__F3 Predicted arsenic resistance pathway in R 413 718 4548 PMC6516512__F1 Major steps in the catabolism of BCAA 586 587 10295 2194 152926 PMC6518944__F3 Metabolic dysregulation in GC‐derived B‐cell lymphoma 5079 10320 2539 2475 3091 4609 23410 PMC6520904__F7 CXCR7-EGFR crosstalk and its effect on the MAPK signaling pathway 1956 1950 6387 PMC6521226__F5 Circadian rhythm pathway identified as one of the significant pathways by the IPA 7432 406 9575 551 PMC6521881__F2 Network of Neurotrophin signaling pathway 7157 627 5609 1398 3265 2932 2885 5604 3667 PMC6523766__F1 Genetic mutations, HIF-1A activation and metabolism of RCC 3939 8178 5155 7039 PMC6526306__F6 BCAA mediate resilience to stress by inducing the hippocampal BNDF/TRKB signaling through the PGC1a/FNDC5 pathway 252995 627 3242 PMC6527025__F7 Apoptosis Signalling in T-Helper Cells During HIV Infection.HIV proteins are involved in apoptosis 7852 920 581 596 317 355 PMC6527602__F2 ERM structure and function in immune cells 6850 6714 2147 3932 2152 8161 6387 6868 PMC6530608__F1 Mitochondria and ER in activation of the NLRP3 inflammasome 129607 9447 114548 PMC6533679__F12 Schematic representation of the underlying mechanism of miR-137 in CC 26585 4087 4088 1000 999 PMC6533757__F3 Immunosuppressive effect of the tumor microenvironment 3576 9235 6387 8205 PMC6534064__F2 A schematic presentation of the Hedgehog signaling pathway and the drugs that interfere with this pathway in DTF 6469 50846 3549 6608 64399 6461 PMC6534790__F2 Coagulation factors and their connection to monocyte activation 2147 7450 2811 PMC6538558__F3 Three example models in the CODA-ML format 2932 1956 1019 1017 4609 2246 2260 842 7316 PMC6538920__F2 Wnt signaling deregulation in the aging brain and in AD 22943 1499 4040 4041 2932 PMC6539048__F6 Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study 4323 1958 7071 3490 7832 3643 7422 367 2099 2353 1959 4089 3397 3398 3549 PMC6541752__F1 Comparison of nucleic acid signalling pathways leading to type I interferon (IFN) production in an autoimmune disease and bacterial infection 11277 115004 7099 64127 29110 3661 3663 PMC6543238__F1 Tumor immunity by radiotherapy and immune checkpoint blockade 942 324 940 11277 115004 PMC6543449__F2 IRFs in the TLR and IFN pathways 7099 3455 114609 7098 54106 51284 6773 3665 3660 3659 10763 5548 3460 10379 PMC6544733__F5 Bioenergetic metabolites differ significantly between the Boxers and Chihuahuas 718 727 717 729 PMC6545365__F1 Schematic Representation of the Biogenesis and Secretion of ExosomesExosomes are formed as intraluminal vesicles (ILVs) 5873 100170220 5874 PMC6545975__F1 Receptor signaling pathway and recruitment of IL-1RAcP 27179 27177 4615 PMC6549079__F4 Signaling pathways related to RUNX2 1950 5741 4087 2932 1499 860 9839 6935 1956 PMC6549480__F7 A schematic molecular model for PSMD3 in the stabilization of HER2 9097 5709 3916 PMC6555193__F4 Cancer pathway gene set targeted only by natural products for a cancer driver target 9134 1026 1027 8900 7157 1017 1820 1869 898 890 144455 79733 PMC6557983__F1 Pathogenesis of hRSV and molecules with a biomarker potential induced in the airways during hRSV infection 7099 7098 4615 90865 3579 3577 85480 6761 400410 920 7054 PMC6558092__F1 PD-1 signaling pathway in T cells.When engaged with a ligand, PD-1 becomes phosphorylated at its cytoplasmic tyrosine residue, leading to binding of protein tyrosine phosphatases (PTPs), such as SHP2 940 3932 7535 10538 PMC6561926__F9 Schematic depiction of lncRNA-p21/EZH2/STAT3 pathway 100124700 6774 7808 PMC6562376__F1 B1 integrin induces EGFR- or HER (ErbB2)-targeted therapy resistance 1950 8829 2064 1956 6714 PMC6562585__F4 Regulation of YAP/TAZ in epidermal cells 55233 92597 9113 26524 23558 6714 3688 PMC6563125__F8 Model of interaction between an oncolytic virus and the host type I IFN response and cyclin expression 6772 10379 4938 1017 PMC6563602__F1 Complement system as a biomarker of disease activity and response to treatment in multiple sclerosis 718 721 720 730 729 717 735 716 715 PMC6566438__F7 Some of the signaling pathways involved in the differentiation of ADSCs into IPCs 2740 3667 6774 PMC6566801__F2 Possible mechanisms releasing mitochondrial components into the circulation 65018 4976 114548 54106 29110 115004 3569 3439 3606 PMC6567518__F8 Summary of the function of OD-Exo in the odontogenic differentiation of DPSCs through TGFB1/smads signaling pathway via the transfer of mircoRNAs 7040 4052 4088 4087 4089 1832 PMC6567800__F7 Anti-shock mechanisms of molecular hydrogen during sepsis 7099 2932 5879 594855 26291 51738 6010 PMC6568219__F1 Novel insights into cell cycle regulation of cell fate determination 4087 4088 472 1021 1019 PMC6571000__F6 T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection 3695 914 101927204 3108 940 29851 283663 5533 933 3122 259197 4092 959 151449 1875 101929623 100507254 919 3655 9241 915 10125 3399 147525 100506710 10451 3702 441501 8503 64750 114915 4068 7535 3932 917 2534 9051 64170 100506119 284751 29108 84674 3553 1439 80301 3606 1441 8807 7850 3460 3579 3577 643911 7132 23765 3624 8809 3588 5154 1950 PMC6571119__F3 Possible interactions between ASD causal genes and RA signaling 7337 473 6095 22871 8456 PMC6580686__F1 miRNAs regulating the conserved pathways of aging in skeletal muscle 23411 7015 100033819 PMC6581573__F2 Stylized diagram showing the synthesis, degradation, release and uptake of monoamines, synaptic effectors and targets of methylphenidate 7054 121278 6571 1621 150 1813 6530 6531 6532 1312 1814 1815 3351 3350 1812 1816 PMC6581679__F1 Canonical activation of HH-GLI signaling 6608 51684 2737 2736 2932 PMC6584837__F1 PI3K/AKT and cell cycle signaling pathway model of NKTCL 118788 5728 253260 2475 595 2309 PMC6588196__F1 Possible sex effects on aspects of the CR/Met R mechanistic pathways 2475 26291 3479 PMC6591470__F2 Schematic illustration of the cell type-specific effects of impaired PI3K-Akt signaling in AD brain 627 2475 2932 3552 PMC6593264__F2 Dual aspects of GM-CSF immunomodulatory effects 182 945 958 1524 7054 PMC6594622__F5 Tumor- and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures 25932 3702 695 660 7294 7006 100124696 7128 330 8743 3552 7185 7124 6355 10333 6373 970 4283 PMC6595533__F2 The proposed mechanisms by which norepinephrine (NE) and corticosterone/cortisol (CORT) regulate sterile inflammation 1325 3146 1524 1378 2829 114548 7850 3554 PMC6595574__F2 Signaling pathway and inhibitors of inflammasomes 114548 79184 3553 PMC6597188__F1 TNF-driven cell death in donor organ as a barrier to immunological tolerance 7124 8717 7186 1540 8772 11035 197259 PMC6598836__F4 Essential metabolism and mitochondrial regulation on B cells (A) and Antibody-Secreting Cells (B) 613 958 920 355 928 PMC6599049__F6 Proposed mechanism for antiviral activity of manassantin B toward coxsackievirus B3 115004 3661 29110 PMC6599195__F3 Signaling pathway downstream of TLR4 receptor in platelets with related cellular events and their regulatory miRNAs* 7099 2638 51135 8773 7189 7408 114609 929 4615 PMC6600158__F2 Ubiquitination-monitored regulation of the Wnt/Beta-Catenin pathway in colorectal cancer (CRC) cells 324 27338 1499 6049 7090 6477 63893 PMC6600375__F6 TGFB mediates metastasis 118856 4319 51129 PMC6601209__F1 Graphic depiction of the gene engineering strategy and glycoproteomics workflow 7956 56913 2589 2590 2591 51809 55568 63917 8693 11227 26290 50614 79695 114805 79623 57452 PMC6602147__F10 Proposed schematic mechanism of EBV-associated gastric carcinogenesis via the activation of the PI3K/AKT/mTOR pathway, and its blockade by CMG002 5728 2475 8178 PMC6602412__F2 M6A on the AKT signaling pathway 23035 55615 2475 PMC6605064__F1 Schematic diagram illustrating the UPR signal transduction pathway 22926 7494 83939 468 1356 84260 596 PMC6607099__F1 Potential mechanism of Fn in CRC 1499 201633 4615 51083 PMC6611700__F1 Outside-in and inside-out signal transduction in myofibroblastic activation 1896 7939 387 6722 4088 PMC6613635__F1 Simplified rationale for performing studies in NHP sepsis models of antibody inhibition of TNFA and IL-6 7124 2152 7099 3569 7018 324 5340 PMC6617458__F3 Microbial N-cycle and chitin convergence and degradation pathway mediated through the addition of chitin 6651 8775 22944 PMC6617489__F5 Lipotoxicity of VLDLs on mediating maladaptation of calcium regulation to derangement of sarcomere proteins in atrial myopathy 7436 84876 6786 51199 PMC6620681__F1 De novo and salvage pathways for NAD+ biosynthesis 4837 130013 10135 23475 93100 PMC6622839__F9 Model of VAMP3- and VAMP7-dependent surface transport 6845 8224 8773 9341 PMC6625751__F1 Type I interferon in rheumatic diseases 7099 929 4615 7297 3716 54106 51311 51284 57506 51135 3654 115004 7098 6772 6773 11277 3661 3665 7124 7189 3659 PMC6626595__F2 Biosynthesis pathway of sialylation 6480 84620 338596 6489 51046 7903 29906 8128 27090 10610 81849 55808 30815 256435 8869 6487 6482 10402 6483 6484 10020 54187 140838 55907 PMC6627931__F1 Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation 90865 7099 6761 4615 27035 4050 PMC6627937__F7 Graphical illustration of the proposed mode of FBXW5-induced regulation of intracellular signaling in gastric cancer 54461 387 6093 998 6714 PMC6627996__F3 TLR4 signal pathway in oxidative stress 929 7099 114609 4615 51135 PMC6628350__F8 Liraglutide attenuates diabetes-associated neointima formation and pathogenic EndMT via the AMPK pathway 3553 4087 4088 PMC6628492__F4 Synthesis of BDNF and potential downstream involved in the effects of botanicals and active components on depression 1392 627 387 5879 2475 PMC6637313__F1 Cellular and molecular responses to extracellular and intracellular DNA 1776 1773 4615 3458 958 1777 3146 100187907 115004 11277 613 PMC6642071__F1 Methionine–homocysteine cycle and biosynthesis of betaine 51734 22921 4482 635 4397 55349 875 PMC6647277__F5 Curcumin actions on the WNT pathway in cancer therapy 6774 2932 572 2475 1499 PMC6651518__F10 Mutual interactions of expression of the genes examined with qPCR and shown in , and 7414 81027 284217 4478 3576 5747 858 999 2335 3569 7094 3909 7422 5962 7076 60 PMC6652211__F6 Possible EPO signaling pathway 2056 2050 2057 613 5335 PMC6656421__F8 IPA Network 3972 3630 3973 3643 57706 5869 2627 3284 1586 1583 PMC6659691__F1 Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer 3458 3565 3596 3586 1437 3460 3606 50616 3717 940 959 3558 942 941 7099 958 7124 7422 3627 6364 PMC6662310__F1 Schematic of TriPOINT 2013 652 5600 4086 1432 4093 55364 6300 5603 5595 5605 5604 5894 8503 3845 3265 2247 3480 5295 5293 5290 5294 PMC6664079__F3 Potential targets for immune modulation during chronic progression of implant-related bone infections 1493 201633 3902 PMC6668073__F4 Hedgehog signalling and SMO inhibitors action in MB 6608 51684 2736 2737 5727 2735 8643 4613 PMC6668446__F6 GLI1 activation by non-classical pathway integrin AvB3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis 6608 51684 2735 648 PMC6669816__F8 Mechanism by which eucalyptol protects APAP induced liver injury 1571 9817 847 351 PMC6670035__F6 Proposed role of TGFB1 in HASM cell contractile responses in asthma 4088 4087 387 5144 4089 196 PMC6670099__F10 The role of PLIP1 in TAG biosynthesis during development of wild-type (WT) and dgat1 seed 355 54947 5091 4018 8694 PMC6671870__F5 Sirtuins and epigenetic regulation of immune cell functions 8205 23411 7099 23410 23409 23408 51547 51548 22933 PMC6676786__F2 TGFB family members exhibit distinct effects on heart hypertrophy TGFB binds to its own receptors RII and RI, activates TAK1, SMAD2/3, and p38, and moderately promotes cardiac hypertrophy 3479 9518 389400 4087 7049 4088 PMC6677770__F7 Scheme of SAMHD1’s role in HMA metabolism and effector functions 978 1633 25939 1635 1786 PMC6678695__F7 Scheme of autophagic cell death induced by the combination of Oxaliplatin and DHA 2922 83939 83667 468 PMC6679009__F2 Canonical WNT/Beta-catenin pathway 22943 324 1499 4040 4041 PMC6679203__F1 Signaling in AML FLT3-ITD 2322 6850 2885 2475 572 1977 PMC6679874__F4 Regulation of genes and myomiRs expression in the IGF/PI3K/Akt signaling pathway during myogenesis 6722 5728 2475 2309 4087 4088 4208 4620 4656 5081 4617 PMC6682198__F8 Schematic mechanism of apoptosis in ovarian cancer and some current targeted molecular therapeutic approaches 7124 355 2475 331 2626 4671 PMC6682713__F1 LncRNAs regulate angiogenesis through modulating multiple signaling pathways 5820 100129983 728655 55109 139728 6774 3091 2475 7422 51129 PMC6685084__F1 The genetics of human hematopoiesis and its disruption in disease 8833 920 5132 PMC6685136__F2 Wnt/Beta-cat signaling pathway 4040 4041 55366 54894 84133 59352 8549 324 PMC6685392__F1 Dysfunctions in canonical Wnt-Signaling contribute to the neuropathology of Alzheimer disease (AD) 4040 22943 2932 351 1499 PMC6687952__F7 Pathway convergence of proteins encoded by both ASD DMRs 3480 8660 3717 2885 2475 1571 572 PMC6689035__F7 Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells 10133 55170 3920 468 PMC6689231__F2 Insulin signaling pathway 3643 5170 3667 PMC6689752__F1 Regulatory effects of micro-RNAs (miR) on specific stages of neuronal development 58155 9253 3984 23369 5725 PMC6691039__F2 Endothelial theory 7450 847 1003 PMC6691376__F8 Schematic model for the positive feedback loop between fibroblast activation and ECM deposition mediated by CD44-RhoA-YAP signaling pathway 1431 960 387 4485 9113 26524 PMC6692500__F5 Sodium and potassium loci in behavior, thermoregulation, and weight loss networks 196 64838 125 51085 26291 6326 5314 257194 627 5915 84314 5334 79068 152 9369 23770 5534 1620 9486 1548 3360 10446 PMC6694743__F6 Physiopathology of JCPyV in the brain 4763 6667 3091 1958 3667 PMC6696953__F2 ASD gene networks constructed with PASCAL associated genes and its FunCoup interactors 100 6613 10492 4841 55646 57009 805 3781 10189 26354 3185 3609 5972 PMC6697022__F2 Tyrosine kinases in the development of atopic dermatitis 3717 3718 85480 3716 613 6850 PMC6700727__F5 In vivo induction of demyelination by direct Mycobacterium leprae injection into sciatic nerves 2064 3932 4280 PMC6701280__F7 IH protection against liver fibrosis 4313 4089 4088 PMC6702336__F3 Summary of the role of the ERK1/2signaling pathway in CIRI 1956 2002 581 9927 PMC6703304__F2 Inducers and regulators of IFNA production by plasmacytoid dendritic cell 324 5132 51284 54106 PMC6703304__F3 Schematic picture of the type I interferon production and different nucleic acid sensors 57506 115004 51284 54106 4615 3661 3665 51135 7189 3394 3428 51428 3663 100187761 11277 PMC6704447__F11 Model for Rac1 involvement in TGFB1–driven renal fibrosis 27035 28755 1956 6714 4088 4089 PMC6706170__F1 AvB5 integrin/FAK-mediated phagocytic pathway in TM-1 cells 140885 961 948 51454 7074 3611 391 1793 5879 29 PMC6709637__F9 Summary diagram 7040 7048 7046 960 6722 PMC6710038__F7 Schematic model of the mechanism that MIR210HG promotes tumorigenesis and metastasis through a ceRNA pattern in IBC patients 100506211 4087 999 PMC6710795__F8 Proposed model of dovitinib-mediated autophagy and apoptosis with regard to the SHP-1/p-STAT3 pathway in breast cells 6774 4170 595 PMC6712451__F5 Subnetworks of special pathogenic pathways corresponded to different metastasis lesions 6776 4893 8085 9757 2670 2064 1950 9611 7057 58508 8850 3084 27327 9070 3845 1839 861 57690 2623 3265 4092 864 54778 4089 51176 7050 4088 1956 4087 7474 1080 5933 4609 3267 338 185 8322 2066 PMC6712945__F5 Schemes for nanoparticles loaded with specific agents to target TAM signaling pathways 729230 51284 594857 PMC6713433__F6 mRNA-miRNA-pathway regulatory network 3593 3579 944 6011 PMC6714137__F11 Schematic representation of inhibitory effect of miR‐539 on EMT and metastasis of PCa 4089 1745 999 PMC6714402__F5 DEGs involved in estrogen and prostaglandin signaling pathways 4790 148327 3725 64764 1432 1839 6714 5580 3709 5601 53358 2778 112 4313 10488 2776 PMC6716105__F7 Mechanism of the NFKB Signaling Pathway Mediated by LINC01093Overexpression of LINC01093 can target ICAM-1 negatively and then inhibit apoptosis and enhance proliferation by suppressing the NFKB signaling pathway, thereby attenuating AH 3383 100506229 836 581 PMC6717289__F6 Our proposed model of KRAS and TP53 oncogenes driving PDAC malignancy via the ARF6–AMAP1 pathway 3845 7157 5159 7005 2118 2475 27250 9230 9961 6935 382 1977 57669 PMC6718562__F6 Role of IL-1 cytokine family members in the immunological history of the hepatocarcinoma 3458 374 978 619501 90865 8205 114548 PMC6719725__F6 Assessment of network module identification across complex diseases 1493 868 4353 5447 5966 920 8320 203100 6775 9402 7033 253260 27429 27040 84666 112744 55620 6503 5970 100131693 9046 10750 7032 PMC6720052__F7 Schematic of the signalling pathways involved in AVE 0991-attenuated pyroptosis and hepatocyte damage induced by heat stress by inhibiting the ROS-NLRP3 inflammatory signalling pathway 3603 114548 50507 PMC6720954__F1 Upper, matrix metalloproteinase 1 (MMP1) cleavage of protease-activated receptors (PARs) result in increased Ca2+signaling 355 4316 4312 4321 3454 3455 3458 1230 4313 6354 23379 3579 2920 972 PMC6721448__F3 BRAF-mediated signaling in normal and cancer cells 3082 1956 4763 2475 673 1019 PMC6721670__F5 Canonical pathways linked to hNgb binders in a non-stress condition 7006 100124696 2000 6010 PMC6721670__F6 Upstream regulators and signaling cascades linked to the hNgb protein interactors in a non-stress condition 2247 4602 4832 7431 90993 1029 3397 5978 7345 1956 43 351 5581 7534 10399 3309 58157 207 53358 2130 PMC6729001__F7 Schematic model of METTL3 in regulating CRC 56339 100302142 200734 PMC6737211__F5 Activation of Ser/Gly synthesis from glucose, their efficient incorporation into purines, and reverse flux of the Ser–Gly one-carbon pathway underlie preference for glucose as substrate for purine synthesis in lung cancer tissues ex vivo 26227 4522 6470 914 6472 2731 25902 441024 10797 PMC6745179__F7 CD28 KO reverses lung blast injury by the PI3K/Akt/FoxO1 signaling pathway 940 3603 960 9332 3553 581 914 PMC6745219__F2 Tumor Necrosis Factor Receptor 1 (TNFR-1) Signalling Pathway 8717 8772 7186 581 637 PMC6745708__F1 The RTK signaling network and nodes of therapeutic blockade 1950 3082 2668 1956 238 5979 3480 2475 PMC6749033__F2 Metabolic regulation of pleotropic autophagy 51451 4837 10641 8408 PMC6749452__F8 The metabolic pathway networks of particularly significant potential biomarkers for the therapeutic effect of p-b4 on MSU crystal-induced GA rats 240 3931 4048 4056 2531 PMC6753603__F2 Schematic overview of the two most common pathways with genetic alterations in thyroid cancer—mitogen-activated protein kinase (MAPK) and phosphatidylinositide 3-kinase (PI3K) pathways 5979 2261 2260 2263 4763 238 5728 7249 7248 2475 PMC6754407__F7 Model of SHH induced increase of HELLS 6469 10413 3070 PMC6755353__F1 The endosomal Toll-like receptor 7 (TLR7) in remodelling of the infarcted heart 3553 3654 51135 51284 4615 3146 PMC6756057__F2 Schematic overview of genetic and epigenetic abnormalities in Wnt pathway components in MM and drugs that target canonical Wnt signaling 22943 50964 84133 4040 4041 55366 54894 1540 324 1499 595 607 4609 6908 6790 PMC6759464__F1 Abbreviated summary of monocyte activation pathways 3929 6362 3603 1401 7099 PMC6765066__F7 HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases 3146 7097 7099 3576 4088 4087 6774 4118 2247 PMC6769561__F2 Schematic summarizing the molecular mechanisms contributing to cancer progression 11076 27035 1956 6774 PMC6769855__F1 Simple depiction of signaling pathways for the activation of classical NLRP3 inflammasome (canonical and non-canonical) and alternative inflammasome 7099 114548 8737 8772 841 834 3553 PMC6770479__F1 Molecular mechanisms involved in inflammasome activation 3466 114548 9447 58484 22861 79792 3603 PMC6770479__F3 Chemotherapy-induced apoptosis and pyroptosis in cancer cell 8772 1687 637 581 PMC6771012__F3 Molecules and cellular pathways that contribute to thyroid cancer development 5979 238 5728 3717 673 324 2932 2475 1499 4193 7157 7015 PMC6771146__F3a Pituitary Transcriptional Response Related to Feed Conversion in Pigs 23054 1387 9968 23524 2033 3054 8085 6595 57634 9739 23067 6597 4297 PMC6771463__F6 Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma 2925 5728 2475 PMC6771568__F2 IGF signalling pathway alterations occurring in cisplatin‐resistant TGCT 5155 3480 5159 5290 5728 207 PMC6773241__F8 Graphical abstract showing the main findings of this study 1874 1956 5894 3265 PMC6773509__F2 Toll-like receptor signaling – general features of the canonical pathway 114609 4615 51135 3654 3656 7189 10454 PMC6775696__F11 Interactions between MKI67 and eight genes related to P53 signaling pathway 841 891 983 1111 9133 51512 4288 6241 11200 PMC6781639__F2 VEGFR structures and their specific ligands 7422 7424 7423 5281 8829 8828 PMC6781692__F1 Shh signaling pathway in hepatocellular carcinoma 6469 6608 51684 2735 2736 2737 6615 596 22856 PMC6791470__F1 T Helper 9 Cells: A New Player in Immune-Related Diseases 3566 6778 4087 4089 3662 10538 2146 2625 50943 2308 PMC6795686__F8 The signaling pathways regulating TREM2 phagocytosis and TREM2 modulation of NFKB phosphorylation/activation 54209 8205 6850 PMC6797603__F1 NLRX1 regulates immune system signaling 7124 114548 7385 7284 57506 5094 79671 PMC6801506__F3 The most significant Ingenuity Pathway Analysis (IPA) network of differentially regulated proteins in the MHO group compared to those from the MUHO group 51434 4893 3858 3501 85451 259 PMC6803483__F1 Metabolic pathway of linoleic and arachidonic acid 4018 4049 4050 PMC6803600__F2 Immunometabolic changes associated with DC maturation 29110 30835 929 942 941 9308 2475 3553 4843 PMC6804569__F4 Metabolic control of T helper cell differentiation 940 3558 3939 PMC6804961__F6 Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer 2475 1009 999 1000 PMC6805690__F1 Notch pathway amplifies intrinsic noise by interactions that improve the efficiency of global protein synthesis 5728 4193 3280 182 4609 1499 2932 3091 PMC6805690__F6 Noise-induced bistability and resolution of fate dichotomies 3280 5728 4851 23462 1499 4193 23411 PMC6808435__F6 RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida 100682260 3081 2184 PMC6808435__F10 RNA-Seq analysis reveals an essential role of tyrosine metabolism pathway in response to root-rot infection in Gerbera hybrida 100682260 3081 2184 PMC6811524__F1 Canonical/Beta-catenin-dependent Wnt signaling 324 2932 1499 4609 595 4316 PMC6813793__F3 Cross talk of Na+ and Ca2+signalling between the cell membrane and the mitochondria.Influx of Ca2+ into cells is mediated by multiple cell membrane pathways 7442 7225 90550 10367 PMC6815035__F6 MiRNA–mRNA interaction networks containing five cell proliferation and differentiation related pathways 5801 6446 5155 4915 653 51422 10365 2066 5563 7043 3925 10468 5156 6423 5291 PMC6815235__F1 Molecular mechanisms that underlies TRPV1-mediated nociceptive hypersensitivity in the dorsal root ganglion (DRG) neurons from a mouse model of sickle cell disease 6347 7442 136 729230 6774 PMC6819419__F1 Necroptosis molecular pathway 3146 90865 8717 197259 8772 11035 7099 7098 PMC6820556__F6 Model summarizing the ABeta-induced actin cytoskeletal abnormalities via SHIP2-PI(3,4)P2-ARAP3-RhoA signaling pathway 5266 64411 2932 387 PMC6821048__F7 Inhibitory effects of butein on cell proliferation and TNF-Alpha-induced CCL2 release in racially different triple negative breast cancer cells 8772 7186 843 841 840 836 9641 8717 PMC6822566__F1 Complement cascade and its diverse effects of on alloimmunity and inflammation 718 716 717 727 2271 966 4179 PMC6823706__F2 Molecular mechanism of Fetuin-A involved in the pathogenesis of diabetic associated fatty liver disorders via suppression of insulin signaling resulting in insulin resistance 7099 929 4615 PMC6824681__F10 The SGK3 signaling pathway 23673 5163 23678 10228 8674 10490 9482 8673 8417 PMC6826302__F3 Mechanisms mediated through vitamin D 8205 3488 7421 1499 1950 6678 PMC6827009__F6 Activation of CREM signaling pathway in spermatozoa of idiopathic infertile patients post-antioxidant treatment 1401 5566 1636 3948 23617 5573 5576 PMC6827304__F5 DAMGO and morphine differentially assemble protein-interaction networks to control MOR spatiotemporal signaling 156 8826 5879 1399 1828 1823 1832 3728 PMC6827427__F6 TGF-beta signaling pathway annotated by ceRNA pairs of CDKN2B (p15) 100129973 642934 4090 4086 4091 4092 64750 57154 7046 4087 4088 1874 6667 387 6093 5308 PMC6828713__F1 Otub1-mediated regulation of the IL-15 signaling pathway 3600 3716 55611 2475 PMC6830101__F12 Graphical summary of perceived crosstalk of BMP2-mediated signaling and the NO pathway 650 4086 4090 4089 PMC6830763__F1 Brief description of the interaction of a CD4+ T cell with B cells 3458 920 940 958 941 942 7374 PMC6835776__F3 Proposed effects of ZnO nanocomposites on antigen-presenting cells and their potential role in inducing T cell responses in draining lymph node 594857 3458 920 4615 PMC6838412__F7 Proposed mechanisms in SS MSG 3710 57506 3661 3665 29102 677847 1974 PMC6841741__F2 Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Organismal Injury and Abnormalities, Reproductive System Disease pathway 389058 2922 84640 100126304 6415 256949 367 387775 283229 5225 4489 2965 126669 56171 7157 5887 10936 693223 PMC6841741__F3 Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Inflammatory disease pathway 64582 442912 729082 160897 4691 7124 4000 5623 6416 1437 3725 89781 64184 723778 10936 4094 PMC6854237__F3 Microbiota-triggered EMT via E-cadherin/Beta-catenin 1499 324 2932 595 PMC6854381__F6 CMTM7 activates Rab5 which controls the fusion of early endosomes and affects EGFR protein trafficking, an essential part of the PI3K/AKT signaling pathway 1950 112616 1956 PMC6854988__F11 The GO interaction network of coexpression genes (the cnetplot of coexpression genes from BP enriched pathway) 196 1244 5465 6258 6256 PMC6856358__F8 Proposed signaling pathway of this study 10642 4105 2735 4609 3481 2475 1956 PMC6857099__F4 BRD4 is involved in the transforming growth factor B (TGF-ß)/SMAD signaling pathway 4087 4088 4092 4089 23476 PMC6857915__F7 Chronic obstructive pulmonary disease 3558 3565 3574 3623 3977 1896 2660 4838 55801 7173 4352 7038 50604 268 3952 PMC6858953__F1 Claudins inhibit multiple oncogenic pathways 5163 9113 5164 5728 595 3480 PMC6862668__F1 Signaling pathways and therapeutic targets 7422 27302 140805 5728 2022 3845 PMC6864436__F7 The schematic diagram of ICA activation of BMP2–induced osteoblast differentiation in C2C12 cells 650 4090 4086 4093 860 PMC6865084__F3 Core genes involved in the promotion of depression in patients with ovarian cancer 5327 5368 6387 2354 5054 3726 7538 6678 3727 6347 2353 1281 1958 467 5352 1843 4060 1634 7078 5549 1848 56994 3831 1510 1471 55365 7941 710 6597 1508 PMC6865334__F8 Potential pathway for enhanced invasion upon mechanical stimulation 5879 5058 3984 PMC6869463__F6 Schematic showing the role of CNPase/Notch signalling pathway in modulating EMT and fibrosis 4089 4087 4088 7042 PMC6870983__F2 Schematic model of the mechanism of HuR-regulated tumor cell migration 1956 7358 6615 4318 9112 11031 7040 23411 PMC6872668__F8 Increased Smad3 and reduced Smad2 levels mediate the functional switch of TGFB from growth suppressor to growth and metastasis promoter through TMEPAI/PMEPA1 in triple negative breast cancer 4088 4087 5728 PMC6873089__F2 Mutational landscape of HCC 7157 1029 5925 7015 898 472 8312 324 196528 2475 9965 7422 4780 9817 5266 5728 3845 7249 7248 6197 3572 213 338 2244 3716 PMC6873406__F10 Non small cell lung cancer pathway circuit 1956 595 2885 3845 11186 2064 572 5728 6774 3718 1950 PMC6874977__F3 PPI network analysis 51083 4852 2357 10022 2587 6752 3576 5473 2920 8843 1268 6372 3577 2358 8862 4886 1237 183 6288 56477 5539 2786 6751 5367 6387 2919 2151 2641 1908 257313 387129 185 60675 2922 5021 2828 1128 2921 2792 6750 PMC6877505__F1 Schematic view of microglial activation and cross-talks between microglia and other immune factors in the pathogenesis of Parkinson’s disease 942 9021 3553 6364 6347 627 3479 PMC6877906__F2 Proposed model for the role of TLR-mediated innate immune events in regulating the Th1/Th17 and Th2 immune balance 57506 7098 7097 7099 51311 5132 PMC6880379__F3 The Atm-Aim2 axis in neuroinflammation and neurodegeneration 9447 3553 472 PMC6881211__F9 Emerging roles of the long non-coding RNA 01296/microRNA-143-3p/MSI2 axis in development of thyroid cancer 124540 6774 595 PMC6881651__F10 The Action circTTN Competitively Sponging miR-432 Mediating Myoblast Proliferation and Differentiation 3481 4654 5111 1017 4617 595 4656 PMC6886017__F6 Diagrammatic representations of putative mechanisms of microRNA 375 in regulating metadherin-induced cell proliferation, cell migration, and angiogenesis in human colorectal cancer 3845 92140 494324 673 5266 4792 4790 5970 7422 1499 PMC6886858__F4 A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus 834 355 64135 5347 3665 6347 3627 6772 3659 8743 5371 PMC6887669__F1 Two‐signal model of inflammasome signaling 114548 3603 3553 PMC6890986__F1 Apoptosis and necrosis pathways 8737 11035 197259 581 PMC6890986__F7 Pyroptosis 114548 57506 79792 PMC6894227__F1 Metabolic pathway of DEGs related to lipid metabolism in the liver by DNA microarray analysis 2167 2180 2182 1962 2222 3158 1718 10858 9420 1581 6718 PMC6895530__F6 Working model 2475 581 596 PMC6896004__F9 A proposed pathway of DOCK1 in the regulation of growth and motility of CLBC cells 1793 5880 5879 23076 PMC6896163__F2 FOXO1 regulates activation and function of dendritic cells 7099 3383 1236 2308 253260 2475 PMC6906312__F6 Ingenuity Pathway Analysis (IPA) of differential metabolites in POD 7 between GIK and TPN 1356 4553 100302522 51378 PMC6907041__F7 PBR-BuOH suppressed IgE/Ag-mediated allergic responses that are initiated by FcERI signaling pathway 2534 6850 9846 PMC6908489__F4 ROS contribute to ICAM-1 and PD-L1 induction in salivary gland epithelial cells through a JAK(1/)2/STAT3 pathway 3383 3716 6774 3458 PMC6909742__F2 NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology 50507 53905 50506 PMC6909891__F1 Mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2 signaling pathway and function 3479 7249 7248 8408 PMC6909929__F1 Proposed model of myostatin-induced skeletal muscle wasting and insulin resistanceMyostatin binds to it’s receptor (ActR2B), phosphorylating the Smad2/3 pathway 3479 3667 4087 4088 4089 208 2475 PMC6910162__F1 Overview of metabolic pathways in atherosclerosis and trained immunity 3099 9619 948 355 PMC6912418__F2 Mechanism and signaling pathways involved in mitochondrial adaptation in heart following exercise 3479 163732 6722 PMC6913804__F1 Schematic overview of cell death pathways affected by Coxiella burnetii effector proteins 581 572 7792 PMC6914362__F10 Metabolic control of BRISC-SHMT2 assembly regulates immune signaling 3454 3455 6472 PMC6916502__F7 Proposed mechanisms for panx1 regulating ferroptosis in renal IR injury 24145 2495 8031 PMC6916680__F5 Suppression of proliferation and invasion and enhanced apoptosis of breast cancer cells by inhibition of expression of PI3K and its downstream signaling pathway by oxymatrine 1017 2932 595 4318 PMC6920321__F2 NFKB Signaling Pathway(Left) Canonical pathway of NFKB activation 958 7124 4055 4615 1956 7186 8915 5966 10892 6774 5971 PMC6920374__F6 The role of Wnt signaling in hiPSC-CM differentiation 64321 3170 8320 5156 3791 55897 PMC6923546__F5 Schematic representation of the proposed model: blocking PRMT5 promotes lung cancer cell death via Akt/GSK3B signaling pathway induced by resveratrol 637 10419 2932 PMC6925592__F2 Smad7 Restricts DC Responsiveness to TGFB and Their Ability to Induce Tregs 4092 3397 10468 7045 268 3623 145258 5155 3624 2022 10140 3398 861 6659 25805 50943 2012 4609 269 2122 920 4295 PMC6927547__F1 Key anti-obesity strategies and pharmacological agents 155 3717 6774 3516 100188776 7350 63976 PMC6929101__F1 Schematic representation of Transforming growth factor-beta (TGFB) superfamily signaling pathway 4089 4087 4088 4090 4086 6010 PMC6929101__F3 TGFB activation in the tumor microenvironment 8205 9242 3589 6387 PMC6930194__F1 Schematic illustrating interaction of key elements in the tumor stroma in CCA progression 9242 6347 2919 3569 7424 80310 5159 7422 3091 PMC6931156__F3 Rab Proteins Have Convergent Roles in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis (FTD/ALS) and Parkinson’s disease (PD) 120892 29058 203228 25978 11021 57679 10890 29110 116442 5861 PMC6935754__F1 Hypotheses for the accumulation of amyloidB42 and tau pathology linked to cognitive impairment and epileptogenesis in TLE 102 23621 2475 351 PMC6937972__F6 Strong association of calcium channel activity in NRXN1A+/− iPSC-derived neurons 6751 5321 8862 6387 2151 10874 6385 5367 3371 5627 183 1129 3269 1601 5376 2786 7042 3062 3691 2911 2697 7048 5923 858 7049 773 816 5156 5154 6237 10369 10368 2257 8822 781 116444 5522 107 7222 8911 11151 1141 PMC6943360__F1 An overview of MIF signaling pathways: MIFs interactions can contribute to the formation of cancer and neural development 4282 960 972 7852 3579 572 581 PMC6943435__F1 Metabolic remodelling in lung cancer 1956 3845 3099 238 2729 3939 5091 47 PMC6944118__F8 Working model of the role of HERC2 in p53‐MDM2 loop regulation 4193 472 545 8924 84461 PMC6944396__F1 Schematic of the proposed pathways whereby mitochondrial dysfunction impacts chronic obstructive pulmonary disease pathogenesis 65018 197259 11035 PMC6944532__F3 Representative Examples of Gain-of-Function (GOF) Mutations That Perturb Signaling Pathways 8912 3708 7015 3667 PMC6945172__F5 Schematic of fatty acid Beta-oxidation, oxidative stress response and cholesterol absorption processes in the enterocytes of mouse 4547 373156 2947 64240 64241 29881 948 39 641371 10449 10965 PMC6949682__F5 Canonical pathway; (b) heat map of the genes related to the colitis signaling pathway in colonic epithelial cells obtained from wild-type (WT) and Slc5a8-null (KO) mice fed the fiber-free diet (FF-diet) 1215 84634 54328 2796 3623 359787 148523 3105 5465 6996 8876 735 3283 915 6561 916 3860 7432 3500 2151 1559 7097 4843 27035 9046 30009 64499 84867 6812 1577 1668 4149 PMC6951466__F4 Ingenuity Pathway Analysis (IPA)‐based plausibility analysis of candidate single nucleotide polymorphisms (SNPs) 3953 154 185 5979 2778 5328 4313 1356 1234 6256 5465 PMC6952548__F7 HCMV miRNA-mediated regulation of TGFB production and signaling during viral latency and reactivation in CD34+ HPCs 947 4664 1958 3066 51199 PMC6952788__F6 Cartoon illustrating the role of RAC1B in negative regulation of the epithelial-mesenchymal transition (EMT) program in (pancreatic) epithelial cells 6615 999 7040 PMC6952948__F6 The role of mTOR in the pentose phosphate pathway and nucleotide synthesis 2539 22934 7086 4609 5634 471 790 4975 10797 3615 PMC6953035__F10 Proposed model depicting the impact of PC1/3 knockdown on the activation of TLR4 7099 4615 6774 107966124 3661 PMC6959099__F2 Metabolic changes associated with innate immune responses in lung disease 260431 85480 90865 355 PMC6959132__F6 BDNF-signaling pathway mechanism 627 342538 5266 PMC6965011__F2 Proposed model depicting regulation and role of METTL3 and FTO in BMSC adipogenesis and osteogenesis with regard to osteoporosis 5468 79068 10220 2167 3716 5741 5745 860 PMC6969104__F9 MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer 5091 1019 4609 6657 6935 2146 PMC6973314__F11 Role of BST2, E-cadherin, and signaling pathways in IFN-Gamma-mediated decrease in invasion of HTR-8/SVneo cells 6772 684 999 PMC6975291__F11 The proposed pathway for suppression of glutamate release by postsynaptic metabotropic NMDAR signaling to Panx1 24145 759 2166 6714 7442 PMC6976994__F3 Mechanistic aspects of DME regulation in mouse liver tumors with mutations in either the Ctnnb1, Hras, or Braf oncogene 1571 1499 1543 196 PMC6980436__F1 Heme metabolism and the microglial toll‐like receptor 4 (TLR4) signaling pathway following SAH: In the subarachnoid space, free heme is metabolized by heme oxygenase (HO)‐1, releasing iron (Fe2+), biliverdin, and carbon monoxide (CO) 4615 3383 3146 7099 54106 PMC6981493__F5 Representation of the cellular response after insulin stimulation 572 581 2932 PMC6982088__F1 Cyclic production of melatonin, from external (e.g., pineal and possibly extrapineal sources) or internal uterine sources, is responsible for promoting decidualization and improving implantation 15 438 9575 2066 1839 3549 6770 1583 406 7157 2662 9518 5743 3976 650 652 654 PMC6985874__F1 SCF is highly expressed in IPF lungs and blood 3550 3685 5292 60 10661 2444 4208 6129 4792 6774 PMC6988351__F8 Inflammasome pathway 325 1401 3553 PMC6990917__F8 Mechanism of the protective effect of fenofibrate against diabetic nephropathy 5465 26291 208 2932 2534 1728 PMC6995390__F2 Signal transduction pathways in PSCs activation 6010 4092 4087 4088 8434 3549 6469 26291 PMC6996149__F1 Two major pathways of bile acid synthesis in mammalian liver 1593 80270 10858 9023 1582 9420 51302 1581 PMC6996643__F2 Meta‐analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis 929 7099 3929 114609 4615 4792 7128 3586 1672 3661 PMC6999766__F8 Schematic diagram summarizing the therapeutic effects of the flavonoid ingredients isolated from Abelmoschus manihot (L.) Medik flowers in multiple myeloma 3099 3101 4280 PMC7002700__F5 Schematic showing the signaling pathway of miR-125a-3p- Fyn–NRP1 interaction by TNFA in DPSCs 8829 2534 1499 1834 PMC7002987__F3 Cytokines that inhibit or stimulate melanogenesis 7124 3553 90865 PMC7003380__F2 Targeting regulatory and/or effector T cells with ICOS agonistic or antagonistic antibodies 324 29851 941 942 PMC7004311__F1 One-carbon metabolism 2548 57412 2593 10400 635 4548 4524 5091 PMC7004529__F1 Characteristics of cellular senescence 1017 1019 1021 PMC7005212__F4 Compound-potential targets-disease network (Blue diamond represents compound target; red circle represents pathway; purple hexagon represents disease) 5970 7124 4128 5743 65057 PMC7007879__F7 Potential differences between Socs3 and Cish gene expression 1154 9021 6046 PMC7011400__F5 Proposed model for the effects of BSZYD on HEMEC angiogenesis through the VEGFR-2-mediated regulation of the MAPK signaling pathway 4318 5111 595 PMC7016661__F2 TNF-TNFR2 signaling pathway 7124 7186 8737 PMC7016982__F2 Pathways and interplay with regulate mechanotransduction in the context of chronic disease and polarity 6010 7350 3667 9780 59341 PMC7017004__F1 Signal transducers and activators of transcription (STAT)3 and STAT5 signaling in epithelial ovarian cancer (EOC) and tumor microenvironment 920 3976 3977 5771 11122 PMC7017008__F2 Main molecular mechanisms underlying EMT activation 3082 6774 1950 6010 4087 4088 7291 PMC7018659__F8 Possible mechanism underling periodontal inflammation-induced metastasis 7097 7099 114548 6347 3553 6352 6374 6387 PMC7019684__F2 mTORC1 is activated by amino acids, such as leucine, HMB, and arginine 652968 2308 1977 8408 664 PMC7019732__F6 FIPV nsp5-mediated inhibition of the type I IFN signaling pathway during FIPV infection 57506 7186 7188 7189 29110 3661 PMC7020748__F2 Key pathways most frequently mutated in MPM all contribute to global downregulation of microRNA levels 4771 596 26524 4193 8314 2146 4609 29102 PMC7025498__F11 Celastrol-suppressed VM and angiogenesis in glioma 7422 2475 1003 1969 PMC7028499__F7 21-BENZYLIDENE DIGOXIN DECREASES PROLIFERATION BY INHIBITING THE EGFR/ERK SIGNALING PATHWAY AND INDUCES APOPTOSIS IN HELA CELLS 1956 581 842 836 PMC7031145__F6 Inhibition of transforming growth factor B pathways caused by caffeine 7048 7046 4087 4089 4088 1490 PMC7033031__F9 TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching 7099 59341 6347 2919 PMC7033114__F8 IDO1 and TDO contributing to the malignancy of gliomas 4280 3620 196 361 PMC7034838__F3 Iron metabolic pathways in the processes of sponge plasticity 210 79747 7909 2235 58157 7390 5498 7389 1371 PMC7035145__F13 Schematic showing integration of inputs in the SIP syncytium 4842 7432 5156 55107 PMC7037725__F1 Molecular mechanisms underlying GOLPH3 function in human cancer 26207 64083 399687 81876 387 1956 2475 6774 3717 1499 PMC7042114__F1 BNP plays critical roles in itch transmission 83737 4879 3269 57105 6750 3355 3350 1901 7442 140803 2922 6364 4318 3627 PMC7044792__F1 Extrinsic pathway of apoptosis 7124 8772 8717 637 PMC7044792__F4 HIV-1 and necroptosis 8737 11035 197259 3606 PMC7049974__F1 Sterol reductases in cholesterol biosynthesis 1718 3930 1717 PMC7050993__F5 Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion 10392 2475 6364 920 50943 PMC7051019__F2 a) Signaling pathways and transcription regulation of adipogenesis 3630 3479 10682 23411 22933 PMC7051146__F1 Pro-viral roles of autophagy during virus infection 2475 8408 57506 9140 PMC7052015__F1 Detailed illustration of the experiment 847 9817 4094 PMC7056742__F2 Activation of NLRP3 inflammasome has involved in the pathogenesis of several renal diseases including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN), IgA nephropathy (IgAN), etc 114548 3553 8772 PMC7056928__F4 Cholesterol auxotrophic lymphomas accumulate squalene, an antioxidant-like metabolite 238 6713 3949 23657 2744 2222 6510 2879 PMC7059861__F1 Main pathways of TRP degradation, including relevant enzymes [modified after (, )] 3620 169355 8564 8942 196 2859 PMC7060471__F2 Pharmacological manipulation of the activity of Wnt/B‐catenin signaling pathway 8658 1499 324 64840 PMC7061741__F4 Schematic diagram shows the proposed mechanism by which the Hippo pathway regulates cervical cancer 374 7039 1956 9113 26524 5784 PMC7061757__F8 Crosstalk between EGRF inhibition and TLR4 pathways in HNSCC 7099 4615 6714 PMC7066404__F9 Potential mechanisms of hKLK1's protective effects on DMED 7040 4087 4088 581 PMC7069501__F3 Therapeutic targeting of trained immunity 948 2475 114548 64127 3553 7124 PMC7070965__F7 EDG and DC on FcERI-mediated signaling pathway in KU812F cells 4067 27040 6850 PMC7072620__F1 HMGB1/RAGE and HMGB1/TLR4 signaling pathways in AD: HMGB1 can interact with extracellular AB peptides and decrease AB deposition by inhibiting AB clearance by microglia, as well as increasing Beta- and Gamma-secretase activity 2932 3146 3553 43 PMC7080238__F9 STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection 115004 114548 834 3553 PMC7082402__F1 Red blood cell—inflammation vicious circle in sickle cell disease 114548 7099 3553 PMC7088895__F1 TGFB and BMPs signaling pathways 4087 4088 4086 4090 4093 4089 2475 PMC7090203__F2 LPS transferring pathway and modulation of TLR4 signaling cascade 7099 114609 4615 7187 7189 3929 3661 929 PMC7090203__F3 Physical activity alters circulating monocyte features and obese adipose tissue macrophage distinction 3458 3661 6772 3662 6778 9314 729230 7097 7099 1234 6347 929 PMC7092451__F6 KEGG pathway analysis of targeted genes involved into proteoglycans in cancer pathway 23533 6655 3059 2335 1655 7430 71 PMC7093020__F2 Overview of crosstalk pathways associated with renal fibrosis and inflammation 1950 7039 3606 1956 4092 4087 4086 64750 PMC7093977__F3 Phenotypic response of microglia on dietary fatty acid exposure 7099 4615 120892 54209 3566 7042 10716 PMC7094958__F2 RIG-I-like receptors: their regulation and roles in RNA sensing 57506 1283 29110 3661 3665 PMC7094958__F4 RIG-I-like receptors: their regulation and roles in RNA sensing 1283 85364 55601 1665 1540 8638 54941 91662 7706 57506 29110 3661 3665 6421 283131 PMC7098821__F1 Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease 65018 9518 26291 PMC7099488__F1 Bile acid synthesis in the liver 1581 9023 1593 10858 9420 51302 1582 4280 570 25801 PMC7102443__F8 Pleiotropic functions of Htt in the TLR-4 signal transduction system in BMMCs 7099 4067 2534 6850 4615 51135 3654 7189 2002 8773 PMC7102917__F2 Major downstream signaling pathways in GISTs 5156 3815 3717 2475 6774 PMC7104985__F2 Broad depiction of the endoplasmic reticulum (ER) stress-driven unfolded protein response (UPR) signaling 83939 468 22926 7186 PMC7106760__F8 Schematic illustration of ADAM10 regulates E-cadherin/Beta-catenin signaling pathway which in turn is regulated by miR-122-5p 102 999 1499 PMC7123501__F3 Simplified scenario model illustrating the intrinsic and extrinsic apoptotic pathways 7124 355 8717 8737 7186 8772 581 841 842 840 836 1674 PMC7123501__F4 Simplified scenario model of the necroptotic pathway 7124 3146 7099 8717 7186 8737 11035 197259 2919 90865 3553 7098 PMC7128029__F1 BA synthesis and transport pathway 5091 1581 9414 9965 5205 PMC7128030__F1 Bile acid synthesis 1593 1581 9420 1582 PMC7136098__F2 Signaling options initiated via wnt5a and the concluded outcome 7474 4920 23002 6010 4772 9242 PMC7139457__F1 Intrinsic apoptotic pathway and interactions between pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) family members 90427 572 8739 637 638 581 PMC7139574__F1 Biological pathways involved in chronic lymphocytic leukemia (CLL) pathogenesis and harboring therapeutic implications 613 958 4055 7187 7186 330 695 100653382 55294 5971 5336 472 PMC7140408__F6 Reductive schematic of the proposed VPA induction pathway in the treatment of ADSCs toward neural differentiation 26291 2261 9655 1956 81831 2670 22902 6328 93107 343450 337 29957 PMC7144527__F8 Schematic model for RNF125 and Cbl-b in LPS-induced endotoxemia 7099 838 837 114548 54941 79792 3553 834 4615 PMC7148637__F40 RV regulation of the IFN amplification pathway 3454 163702 3459 6772 6773 10379 3665 PMC7151129__F1 The retinoic acid signalling pathway during development 64220 157506 9249 PMC7155770__F3 Mitochondrial pathway of apoptosis 317 56616 27429 331 PMC7155770__F4 Death receptor pathway of apoptosis 8772 637 8737 11035 7186 197259 5971 8717 81858 PMC7157599__F2 An overview of intracellular signaling pathway regulation by the HECT E3 ubiquitin ligases 10075 83737 23327 57154 64750 8925 26091 4734 5728 11059 51366 11060 4609 PMC7159845__F3 Cellular model of insulin and leptin signaling in Kiss1ARH neurons 7224 3717 3814 5163 PMC7160660__F3 Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes 2475 4088 50943 940 108348016 861 2113 163882 1040 PMC7161743__F2 Leishmania heme auxotrophy 210 2235 5498 7390 1371 7389 PMC7166192__F3 Process of ferroptosis 2182 2879 4891 7037 10162 84883 30061 PMC7167255__F7 STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch–mTOR signaling pathway 6815 55294 2475 581 PMC7174042__F2 PE and oxysterol pathways and the mitochondria-associated ER membrane (MAM) 1119 5833 5091 81490 9420 129642 10908 9791 10280 1593 51499 23761 113612 9927 9217 65055 PMC7174595__F1 Lysophosphatidic acid (LPA) as a promoter in Alzheimer’s disease (AD) related neurodegeneration 718 4018 387 6010 836 842 572 581 PMC7177281__F1 Neurotrophins and their effect on angiogenesis and neurogenesis in the skin 627 1950 4803 3479 3481 1956 3480 3482 PMC7177758__F3 Positive feedback loops in apoptosis 1616 637 595 PMC7180987__F1 Effects of growth hormone on adipose tissue: old observations, new mechanisms 2690 3717 50486 7038 5346 PMC7182338__F4 BCR signaling pathway and its targeted inhibition 613 930 6348 695 5336 6351 4067 6850 29760 604 PMC7185085__F1 Exogenous LPS directly leads to an increase in the production of white adhesion molecules and other cytokines such as ICAM-1 and vWF 7099 387 3383 7450 3553 2064 2066 PMC7185194__F2 GGIN identified by IPA software 10397 3725 2033 1387 2309 1958 3558 6774 8320 PMC7185194__F6 Novel universal mechanism of immunosuppressive A151 ODN 253260 6774 5170 6009 4609 PMC7186417__F5 Pro- and anti-fibrogenic effects of LPS on activated HSCs 3605 7099 4092 4089 3586 6774 3603 50616 PMC7193059__F1 Neurotoxicity of local anesthetics in dentistry 8772 581 572 PMC7196244__F6 An illustration of how EVO exerts anticancer activity in osteosarcoma cells through the suppressing Wnt/Beta-catenin signaling pathway 999 2932 1499 1000 324 PMC7197128__F6 FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and Beta-catenin activity in ovarian cancer 79633 1875 1499 595 PMC7198260__F2 Ectopic lipids in insulin resistance 3643 5091 3667 PMC7198750__F3 Interaction of the cGAS-STING pathway with other DNA-sensing pathways and its role in cell survival 7019 11277 115004 317 9447 29110 114548 4615 8651 3661 5970 PMC7200337__F6 Immunology of COVID-19: Current State of the Science 59272 6347 3570 54106 51284 PMC7201649__F10 Copper Induces Oxidative Stress and Apoptosis in the Mouse Liver 7124 355 8717 8772 196 847 2021 PMC7203694__F8 Plausible mechanism of CeO2-induced apoptosis of human colon cancer cells (HCT 116) by ROS-generated mitochondrial-mediated pathway 4193 836 317 596 PMC7206374__F4 Potential regulatory modeling of miR126-3p and PIK3R2 in porcine GCs (pGCs) 5296 3643 5163 PMC7207169__F3 MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? 2081 4609 7494 PMC7210384__F1 MGP Promotes Colon Cancer Proliferation by Activating the NFKB Pathway through Upregulation of the Calcium Signaling Pathway 4256 4772 3383 7422 PMC7211213__F1 Simplified overview of canonical Wnt signaling pathway activation 2932 1499 324 PMC7217141__F2 Summary of the processes thought to be involved in thoracic aortopathy development 2200 1281 7076 5592 4638 PMC7218640__F1 CRNDE significantly promotes cell proliferation through mediating multiple signaling pathways and various target genes 643911 221092 494333 6925 1871 143689 10265 1869 331 6362 6774 1499 2932 2475 PMC7219893__F1 (Color online) A schematic overview of the indices of mindfulness and anxiety demonstrating their inverse relationship 1401 920 4026 PMC7222024__F4 Sugar and lipid metabolic pathways affected by oxygen availability 3949 949 948 6510 PMC7222375__F3 Main cell signaling pathway involved in red cell homeostasis 4067 6850 2539 PMC7223841__F2 NAD+ homeostasis in renal health and disease 23475 93100 23530 10135 PMC7226520__F7 Comparative downstream pathway analysis of the effect of the adipocytokine pathway in breast cancer using the SEanalysis web tool for super enhancer associated regulatory analysis 406991 8870 23613 51421 54206 84612 100302185 9618 163732 5121 3875 8551 375759 79083 391257 1907 79977 PMC7226803__F3 Subcellular distribution of FoxO1 driven by nutritive stimuli in white/beige adipocytes 3479 3630 3643 PMC7226825__F2 Anti-inflammatory roles of GFLs and their receptors following air pollution, allergy, bacteria or virus infections 7808 3569 7040 3586 50616 3565 3603 978 4353 9048 2668 4902 5979 2674 2675 PMC7227813__F1 Anti-lipolytic action of insulin 472 5140 4099 PMC7230639__F1 Mechanisms of lactate-BDNF interaction following physical exercise 23411 627 27198 252995 PMC7231083__F1 Type I interferon immune response 7099 51311 54106 51284 57506 7098 114609 4615 7189 3661 7297 6773 PMC7235470__F1 Cytokine storm and stress can increase gut dysbiosis/permeability, further contributing to cytokine induced IDO and TDO, leading to kynurenine and kynurenic acid, which activate the AhR to increase CYP1B1 and regulate the NAS/Melatonin ratio 15 196 1545 438 1557 406 5132 PMC7244035__F7 Schematic figure represented the functions of KIF23 in the Wnt/Beta-catenin signaling pathway in GC 1499 139285 2932 324 9493 9055 595 PMC7246682__F6 Action of fractalkine on JEG-3 trophoblast cells Fractalkine binds to its cognate receptor on the surface of trophoblast cells activating MAPK and AKT pathways 650 4087 4088 4313 4318 6376 1524 PMC7246870__F5 Ingenuity Pathway Analysis (IPA) of five genes (CXCL10, FOS, UBE2N, IL1A, and TLR4) that are commonly regulated by both regorafenib and lenvatinib showed a close association with cell proliferation signaling pathways (red color) 7334 3552 2353 7099 PMC7246871__F5 Closer examination of all drugs and pathways associated with the gene TNF 7124 5468 5241 3358 706 4771 5329 55312 PMC7246985__F6 Proposed model of Amuc_1434* effects on LS174T cells 637 581 2021 PMC7247689__F2 Mitochondrial homeostasis is based on the balanced interplay between biogenesis and mitophagy 2475 7019 65018 4899 PMC7249467__F5 Alterations in Plasma microRNA and Protein Levels in War Veterans with Chronic Mild Traumatic Brain Injury 572 2885 3265 3845 387 PMC7251113__F1 Proposed mechanism of synergy of co-encapsulated vitamin E succinate modified octahistidine-octaarginine (VES-H8R8) and palmityl-doxorubicin (pDOX) 3273 6098 283871 PMC7251178__F1 TGFB and BMP-7 pathways 4088 4087 4089 4086 4090 6010 655 PMC7252250__F4 Pathway 1: Insufficient activation of immune response in the middle ear epithelium cells in otitis media 3552 3606 596 29108 22861 64127 10392 51284 838 353376 64135 114548 7098 57506 64170 84674 148022 7187 4615 51135 3654 9641 29110 834 841 6885 3551 3661 3665 2353 3725 4790 4792 3553 4069 51297 1673 3569 7124 3456 3439 PMC7255347__F1 Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19 7099 3716 7297 7084 6772 6773 51311 4615 51284 6041 6035 7098 57506 8519 29110 3661 3665 10379 3659 PMC7255975__F2 Hypothetical mechanism by SARS-CoV-2 in establishing an inflammatory feedback loop between IL-6 and angiotensin II 6868 59272 367 PMC7258299__F3 Metabolic pathways that produce and interconvert acyl-CoAs involved in histone acylations 47 5132 55902 9425 2639 PMC7260445__F2 Molecular mechanisms that activate membrane damage 8717 8772 8737 729 11035 730 3553 1687 79792 197259 PMC7263368__F1 Representation of Hippo-Yap core kinase signaling cascade 6789 6788 9113 26524 5308 PMC7263368__F5 Representation of Yap regulation by P2y2 signaling 6788 9113 26524 PMC7265313__F9 Final scheme 9928 22897 132320 85302 6608 1611 PMC7270402__F1 Immune landscape of the HBV-based tumor microenvironment 3902 940 324 942 941 PMC7275878__F1 Genetic basis of pneumococcal and staphylococcal infections: inborn errors of human TLR and IL-1R immunity 10333 7096 81793 7100 4615 51284 54106 11213 3654 7189 7097 114609 81858 3553 PMC7278809__F1 NAD+ biosynthesis pathways 4860 10135 93100 PMC7279006__F1 Heme biosynthetic pathway, porphyrias and nutrients 211 2235 212 5498 210 3145 9049 7389 7390 PMC7279384__F2 Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation 6774 3717 5443 181 2693 PMC7279404__F2 Summary of the liquid biopsies activating chemoattraction signal pathways for recruiting immune cells in NASH/NAFLD 3627 9242 8795 54106 1571 PMC7281579__F1 Increased glucose metabolism facilitates endometrial cancer phenotypes 3099 5728 5426 8473 2475 3939 2194 47 3716 6774 2308 PMC7283076__F1 Cytokine storm induced by SARS-CoV-2 4615 3716 7297 3717 6773 6774 6772 10379 3606 3577 PMC7283076__F2 TLR recognizes extracellular PAMPs and initiates the transcription of NLRP3, proIL-1B, and proIL-18 through the NFKB signaling pathway, and oligomerized NLRP3, ASC and pro-caspase-1 form a multiprotein complex that activates caspase-1 3553 114548 3146 PMC7283386__F2 Signaling pathways in wear debris-activated osteoblasts 1499 596 581 PMC7284105__F1 Canonical Hippo kinase module 4485 9113 26524 PMC7285711__F3 Interaction network analysis of the (A) visceral obesity pathway and (B) the cell cycle pathway, using the path designer of IPA 902 9967 7027 898 5925 6474 PMC7288986__F1 HDR-mediated genome editing 653361 1536 3561 PMC7289845__F1 Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer’s disease in the offspring hippocampus 51076 79776 80258 10955 9832 84060 83640 64147 84918 9863 58509 663 25946 10782 65056 7982 695 78988 493911 149041 22954 256714 56944 7732 4735 PMC7290974__F4 Altering host gene expression by disrupting transcriptional regulators 4615 7189 5371 PMC7294136__F1 Functions of extracellular S100A4 protein 6275 7099 1499 PMC7294139__F3 Gene ontology and pathway enrichment and network analysis of blue module genes 1636 4323 6387 2192 10631 5118 4060 7058 1462 1281 8974 7078 4015 2335 169044 7045 1634 PMC7296058__F1 Pentose phosphate pathway (PPP) 2539 6120 7086 PMC7296058__F4 G6PD in cancers 10298 3397 5728 9817 1499 3190 9531 2539 PMC7298859__F7 TNFA/TNFR2 immune checkpoint signaling pathway could be used to target different aspects of tumor cells micro environment 7124 942 941 PMC7299535__F7 Increased CHST15 follows decline in arylsulfatase B (ARSB) and disinhibition of non-canonical WNT signaling: potential impact on epithelial and mesenchymal identity 411 2588 51363 27122 2625 PMC7299681__F7 Proposed model of WDR41‐mediated cellular processes in TNBC cells 2931 55255 1499 PMC7304783__F6 Possible mechanism associated with the tumor-suppressing effect of Romidepsin in DEN-induced HCC mouse model 1499 572 22943 1540 5728 4040 595 PMC7305712__F2 Metabolic liver disease in diabetes – From mechanisms to clinical trials 3630 3643 8660 PMC7308183__F6 Protein–protein interaction network of CFTR (GeneMANIA) 6387 80331 579 10963 5613 7431 3758 1080 1052 55107 154 9497 7430 5575 5243 1182 6351 6356 PMC7308236__F6 Electric Stimulation Hyperthermia Relieves Inflammation via the Suppressor of Cytokine Signaling 3-Toll Like Receptor 4 Pathway in a Prostatitis Rat Model 7099 9021 4615 3553 PMC7311391__F6 Overall regulatory networks of miRNAs, circRNAs and mRNAs 836 596 581 637 PMC7312018__F4 Tamoxifen modulation of membrane and nuclear estrogen receptor (ER) signaling 7040 8205 1950 1956 2852 3611 6714 7018 PMC7312833__F5 Chemokine signaling pathway 6347 3627 3934 729230 2833 1234 6774 2670 3690 PMC7313051__F2 Graphical summary of biological factors influencing anti-tumor immune response constituting three categories depending on anatomical level: tumor cell, tumor microenvironment, and the whole body 3458 567 3716 3717 5728 1499 PMC7316587__F2 Molecular mechanisms proposed for NHE isoforms in cancer 10399 1956 1950 6714 3082 5879 998 PMC7318172__F5 Graphic showing the signalling pathway by which SYT4 regulates melanogenesis via Ca2+ influx 6860 814 4286 1638 7306 4308 PMC7321795__F3 Mechanisms of Selected circRNAs in CAD(A) circNfix leads to the degradation of Beta-catenin and inhibits cell proliferation through combining with miR-214 1499 2932 4211 4784 4904 890 891 65018 1789 49 PMC7322056__F6 Role of HX109 in prostate epithelial-macrophage crosstalk and inflammatory response of macrophages 7099 6774 6351 PMC7322524__F1 Cell death pathways triggered by DNA sensors 79792 3553 115004 9447 29110 3661 PMC7322524__F2 Cell death pathways triggered by RNA sensors 197259 9365 81030 57506 581 29110 11035 3661 8737 7098 8772 PMC7322959__F3 Differentially expressed genes in SPCs of GATA2 deficiency 4000 7112 7390 51071 64151 6005 266710 7532 51327 367 759 PMC7326282__F8 MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer 6789 406953 9113 PMC7326812__F5 Ingenuity pathway analysis (IPA) 7124 7157 338442 90806 9935 5724 2122 2114 7008 6927 687 5465 PMC7327153__F2 TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics 7097 7096 10333 81793 114609 4615 3654 51135 7189 3553 PMC7327948__F3 Diagram describing the possibility for Roflumilast to increase DCX and MAP2 expression 627 1641 4803 PMC7330701__F4 Schematic that illustrates the hypothesis of how the interferon tau (IFN-τ) acts on positive HPV 16 tumor cells 3454 3455 7297 6773 3716 6772 6774 6775 6778 5879 5894 PMC7331746__F2 Essential functions of mitochondrial dynamics in immune cells 940 941 942 4976 920 84895 9927 3659 PMC7333179__F1 Proposed estradiol-induced hypothalamic astrocyte steroidogenesis of neuroP that activates a membrane classical progesterone receptor (PGR)-Src tyrosine kinase (Src) signaling pathway in RP3V kisspeptin neurons to trigger the luteinizing (LH) surge 3814 84634 5241 6714 6770 706 PMC7333652__F8 Microenvironment-related gene TNFSF13B predicts poor prognosis in kidney renal clear cell carcinoma 10673 7043 29924 11157 4282 7371 353 6714 635 27232 PMC7338457__F8 PD-L1 promotes tumor growth and progression by activating WIP and Beta-catenin signaling pathways and predicts poor prognosis in lung cancer 5163 5164 2475 1499 6194 PMC7338464__F7 CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils 6374 2638 999 1000 PMC7340297__F5 Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients 3569 2475 4790 3586 4803 3479 4804 4915 5465 5467 5468 2660 3667 6517 3643 7099 7422 2308 207 84676 133522 10891 PMC7344072__F2 Mechanism by which proinflammatory cytokines in the OA knee joint stimulates MSCs to produce IDO1 274 6772 3620 PMC7346227__F2 Primary cilia control Hedgehog pathway output 51684 2737 2736 5727 23432 6608 6469 4609 PMC7349551__F1 Wingless and Int-1 (WNT)/Beta-catenin signaling pathway 4040 4041 1499 PMC7349719__F2 GH/IGF on the Aging Mitochondria 3479 2690 3480 1431 664 665 PMC7349719__F6 GH/IGF on the Aging Mitochondria 3479 637 572 638 8739 90427 596 3480 PMC7352172__F2 Activation of the NMRK2 pathway represent a common adaptive mechanism in the failing heart where NAD+ levels are low 5465 10135 27231 PMC7352365__F3 The p53/MDM2 pathway by HERC2 545 472 4193 8924 84461 PMC7352608__F2 Therapeutic approaches of splicing modulation in cancer 23451 7307 9584 11338 PMC7358640__F1 Main calcium signaling pathways through Ca2+ channels and transporters involved in the regulation of calcium homeostasis in mammalian cells 7220 140803 54822 7222 79054 7223 7225 59341 55503 6786 84876 93129 57620 90550 770 4827 PMC7361144__F3 Type I interferon pathway during SARS‐CoV infection and modulatory mechanisms, PLpro excluded 7084 3716 57506 7189 7187 10379 29110 3661 6772 6773 PMC7363118__F12 RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination 57506 7706 3661 29110 PMC7364557__F2 Model for tau pathogenesis 1524 114548 2534 1020 PMC7368652__F3 Phosphorylated GSK3B on polycystin-1/2 mutation of polycystic kidney disease 4282 2475 2932 84962 50964 1499 PMC7369235__F8 Signaling mechanisms of BCR-induced CSR 613 6850 695 5336 7187 7186 5971 958 57379 PMC7369379__F7 C-P-T network of top 20 pathway 3725 5327 5328 5465 5578 1147 6347 5970 6256 581 PMC7370155__F1 HMGB1 mediated neuroinflammatory response in TBI 3146 7097 7099 4615 3553 114609 581 7189 PMC7370165__F7 M2 polarization of tumor‐associated macrophages is dependent on integrin B3 via peroxisome proliferator‐activated receptor‐G up‐regulation in breast cancer 948 2194 8205 PMC7372553__F9 CTNND1 function in systemic disease 999 1499 387 PMC7374866__F7 B.coccineus ethanol leaf extract induces cell cycle arrest and apoptosis via the p53 dependent pathway 581 637 572 1019 PMC7378634__F1 Cellular sources and effects of IL-22 7297 6772 6774 PMC7379154__F2 Proposed model of skin-associated B cell functions in Alpha-gal sensitization from tick bites 7097 7099 54106 3458 920 1235 8178 PMC7381287__F1 LPS signaling 114609 4615 7099 29110 3661 3586 3553 3929 PMC7381302__F1 Extrinsic apoptosis execution 8772 572 637 596 581 729 718 735 331 PMC7382785__F4 Illustration of aptamer involvement in cancer immunotherapy 324 941 942 940 958 PMC7384693__F6 Cu-TA’s Biological Targets in MIA PaCa-2 Cells 2064 6667 6774 1063 6502 1649 PMC7385185__F11 The two-way communication between AMs and AECs in LPS-induced airway inflammation 7099 3553 3479 PMC7389684__F10 Schematic illustration depicting a proposed model of the molecular mechanism of PVT1 in gemcitabine resistance in human pancreatic cancer 5820 22863 27161 90780 1499 PMC7395311__F3 Cytokine and receptor Janus kinase pathway 5008 3976 1178 1270 2056 7173 85480 3718 3716 3717 7297 29949 11009 PMC7395429__F7 Proposed model for MBP-induced abnormal cell growth of juvenile SCs 4155 57161 3654 983 PMC7396059__F2 Signaling pathways by NCRs 27040 6850 7409 10451 7410 5879 PMC7397755__F1 Lineage plasticity in cancer: a shared pathway of therapeutic resistance 7157 1956 7080 5925 6657 2146 4609 367 3845 PMC7398066__F2 ABC transporter-related signaling pathways 1392 3479 5091 2308 19 64241 64240 2874 7099 1394 PMC7399786__F7 Roles of miR-33a and its target genes in prostate (top) and breast cancer (bottom), and the underlying mechanisms 2020 7046 5292 1374 3032 6935 6098 8754 2146 56648 PMC7400736__F4 Crosstalk between the insulin/IGF signalling pathways and the potential targeting of let-7 723961 10022 117579 6019 6013 3487 11172 3481 3643 3479 60676 3488 3484 3630 3489 3485 3486 PMC7402324__F1 Simplified scheme of canonical WNT -signaling pathway 54894 84133 2932 324 4117 1499 607 4040 4041 PMC7402324__F6 Compounds and antibodies affecting WNT/Beta-catenin-signaling pathway that were investigated in melanoma (preclinical studies, except for LGK974, which is tested in the clinical trial NCT01351103) 22943 2932 8658 1499 324 607 4040 4041 9118 PMC7403206__F3 Podocyte insulin signaling 3643 2885 6247 6844 PMC7404143__F5 Roles of NRP2 in SMC phenotypic switching 4088 8828 387 PMC7407646__F1 TLR4 signaling pathways activated in microglia during neuroinflammation 3553 3146 7099 197259 8737 841 4615 836 7189 114548 834 11035 8772 PMC7407804__F1 Signaling events downstream of EphA activation by ephrin-As 999 10451 7410 391 387 5879 PMC7408018__F2 ER stress unfolded protein response (UPR) pathways triggering autophagy 22926 468 7494 1649 596 55054 8678 2475 PMC7408918__F1 Androgen at supraphysiological level (SAL) induces cellular senescence through the PI3K/Src/Akt/mTOR pathway 6714 5894 367 2475 PMC7408918__F2 AR antagonist induces cellular senescence in PCa through the Src/Akt pathway 6714 5894 367 PMC7409333__F1 Sphingolipid metabolic pathway (plus five sphingosine-1-phosphate receptors) 2531 8560 10087 7357 64781 259230 81537 8877 427 340485 125981 55331 PMC7411000__F1 Illustration of BPA on LC development 2099 2100 949 3293 6770 1583 PMC7411521__F4 Apoptotic signaling through membrane (lipids)-mediated spontaneous activation of Bax/Bak 90427 638 637 572 8772 8739 841 581 331 842 836 840 PMC7412373__F4 Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways 27250 5728 2475 182 847 1499 4092 4615 PMC7412551__F3 K-bZIP inhibits antiviral innate immune signaling and anti-proliferative signaling 29110 115004 3661 1017 PMC7415495__F3 Molecular mechanisms underlying Beta-cryptoxanthin prevention of cancer development/progression 4318 4313 23411 5915 83875 595 53630 3939 619501 PMC7418797__F1 Therapeutic mechanism related to natural products 3265 4087 4088 4089 324 3611 4092 1499 PMC7426728__F2 DNA methylation regulates the PI3K/PTEN/AKT/mTOR signaling pathway in the resistance to therapy in cancer 5728 572 64798 2475 6297 1789 7045 PMC7429631__F2 Profilin can be phosphorylated at S137 by Rho associated kinase (ROCK) downstream of vascular endothelial growth factor (VEGF) signalling, reducing actin polymerisation rates 6714 6010 5548 PMC7429955__F7 LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression 367 4193 2624 PMC7430831__F6 NOD-like receptor signaling pathway and DEGs in NOD-like receptor signaling pathway from KEGG enrichment analysis of R 10392 64127 79671 3661 3665 7187 29110 57506 PMC7432002__F5 Interaction between IL-1B and I-kB kinase/NF-kB signalling pathway, which have positive activation of Nuclear Factor Kappa B Subunit 1 8797 3718 8772 355 3716 8743 3551 4790 3717 841 602 3594 3553 3605 3606 PMC7432451__F1 ITAM- and ITIM-signaling receptors sense the microenvironment and determine the response of microglia 54209 10326 140885 7305 6714 114548 3553 PMC7432591__F2 Major signalling pathways associated with sarcopenia and peripheral arterial disease (PAD) 3479 1401 6774 2475 PMC7432830__F4 HSP90 involvement in TGFB signaling cascade 4087 4088 4089 PMC7434793__F1 Resistance to BRAF-targeted therapy 1950 1956 673 57670 2475 PMC7438927__F7 Relationship between a network of DEGs and the canonical calcium signaling pathway 3240 51200 27302 5972 25928 142683 57575 9421 26287 129446 1356 PMC7439780__F6 Protein-protein interaction (PPI) regulatory network of proteins involved in the pentose phosphate pathway (PPP) 51071 226 6120 7086 230 25796 2539 PMC7443979__F6 The molecular mechanism of the ascorbic acid anticancer effect 6390 54583 7018 7036 PMC7444376__F3 GCN5 enhances the osteogenic differentiation of PDLSCs 22943 79412 83999 4040 4041 1499 PMC7448422__F7 Schematic diagram of the potential mechanism underlying the miR-590/LRP6/EMT axis in ESCC 1000 4040 999 PMC7449905__F9 Crosstalk between PAK1 and other cancer-related pathways 7003 8463 7004 7005 2475 5058 PMC7449921__F8 Working model of how MAD2 downregulation promotes asymmetric division and reduces tumor growth and invasion in MKN45 cell line 7852 6591 4312 PMC7450153__F1 CGAS-STING DNA sensing signaling pathway 3466 3661 29110 7124 3569 PMC7450153__F3 Protumor role of the cGAS-STING signaling pathway 9242 729230 4790 PMC7453787__F2 BMP-SMAD pathway and hepcidin regulation in different iron states 3077 7036 5045 148738 659 92 164656 654 650 57817 PMC7456147__F1 Human placental chorionic villus showing the different trophoblast subtypes: vCTB, STB, and EVTs in the maternal decidua, the latter arising from differentiation of vCTB through the cell column 10413 7004 51442 7005 7003 8463 389136 PMC7456540__F8 Working hypotheses of two opposing mechanisms that concomitantly drive and silence nerve injury-induced latent sensitization 4852 7442 8989 PMC7457002__F5 ATF3 plays a vital role in breast cancer 4322 467 64083 PMC7460797__F2 1,25(OH)2D3 exerts neuroprotective effects via GDNF 7421 5979 2668 2674 389400 847 PMC7461358__F10 MiR-199a-3p and miR-199a-5p might affect MAPK signaling pathway by regulating DUSP5 and MAP3K11 4149 5327 7374 55742 92 PMC7462931__F7 Hypothesis how decreased expression of glucose transporters in brain leading to a decreased intracellular d-glucose concentration in neurons may promote the emergence of AD 8473 351 10724 PMC7463618__F3 Lipids in regulating NLRP3 inflammasome 7099 948 1374 7351 50507 2194 114548 PMC7465134__F2 miRNA modulators of the mTOR signaling pathway in Adrenocortical Carcinoma 4040 4041 2475 7124 1977 1956 407055 PMC7465134__F3 miRNA modulators of the Wnt/Beta-catenin signaling pathway in Adrenocortical Carcinoma 574038 6935 1499 4040 4041 7018 PMC7468622__F7 TRIM33 affecting renal cancer cell proliferation and EMT through the Wnt/Beta-catenin pathway (requires further experimental proof) 1000 999 1499 23087 PMC7468828__F7 Monophosphoryl lipid A pretreatment suppresses sepsis- and LPS-induced proinflammatory cytokine production in the medullary thick ascending limb 7099 4615 3654 7124 54472 PMC7471649__F6 Protein-protein interaction analysis by STRING 6935 999 7040 1001 2335 PMC7476096__F4 Effect of miR-135a on the epithelial-mesenchymal transition (EMT) 11279 1499 1000 999 PMC7477357__F1 Coagulation cascade and the fibrinolytic system 7018 7035 2147 324 5340 PMC7477441__F7 Mechanism of LINC00355:8 in HCC 619501 1000 999 7480 1499 PMC7477662__F1 Main signaling pathways regulating autophagy 7248 7249 5728 PMC7482807__F2 LncRNAs-mediated endocrine therapy resistance 1956 3480 100128191 1849 100885779 100124700 2099 PMC7482807__F3 Regulatory function of lncRNAs in BC resistance to anti-HER2 targeted therapy 104472715 257000 100130776 4615 3181 PMC7483535__F8 Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration 1813 1816 1644 50632 5860 1312 PMC7483921__F7 Inhibition of Wnt/Beta-catenin signaling by TcdA 1362 89780 2932 324 5879 1499 595 PMC7486245__F1 Components of the TgfB signaling pathway that have been implicated in cardiomyocyte proliferation 4087 4088 4092 4091 4089 4090 4086 PMC7487068__F7 Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy 4166 114548 3553 PMC7490531__F7 Illustration of the IRE1-RIDD-miRNA Pathway in Luminal Breast Cancer Malignancy 7494 5979 5865 PMC7492772__F3 NRX-based and LAR-RPTP-based synaptic organizing complexes display contrasting AB sensitivity 28 351 347731 23621 22871 PMC7493323__F1 CX3CR1/ Fractalkine signalling—different roles in Microglia: In Alzheimer’s disease, chronic neuroinflammation increases the pro-inflammatory stimuli such as LPS, TNFA and IL-6 in the CNS 5978 1524 5763 PMC7493703__F1 Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand–Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib 51621 6348 1234 7422 PMC7494657__F4 Networks under “Pathways in Cancer” that were enriched in Masquelet bone 51384 7474 2535 624 1906 51764 109 8323 1910 2784 81029 1909 7484 10681 7477 5590 182 595 7048 4854 6608 7043 7042 PMC7494909__F5 Intercalated disc protein XinB is required for Hippo-YAP signaling in the heart 4485 9113 26524 1499 4771 1000 PMC7494983__F5 Epigenetic modification and therapeutic targets of diabetes mellitus 3667 10682 7124 PMC7495088__F9 PIgR regulation in CF lung 1080 5284 3605 PMC7500922__F4 Revisiting the PD-1 pathway 3454 3716 6774 840 PMC7503838__F11 Therapeutic targets for brain injury for nanoparticle mediated drug delivery 594857 627 2056 PMC7518857__F4 Hedgehog signalling is initiated at primary cilia 23432 5727 6608 6295 PMC7520283__F3 Activated NF‐KB signalling pathway in OA‐FLS inflammation 3553 7412 7018 3383 PMC7520422__F9 Sphingosine-1-phosphate (S1P) acts in both S1PR dependent and independent pathways 56848 8877 8737 7186 PMC7522761__F1 Interferon signaling from dermatomyositis skin analysis 3458 4047 7297 6773 8554 581 10379 3659 3434 5696 PMC7522761__F4 Ingenuity Pathway Analysis of candidate genes downstream of interferon-alpha signaling from dermatomyositis muscle analysis 4139 6775 6773 6774 6772 5970 344 2027 3105 3107 7037 24145 2184 3123 4609 960 PMC7522761__F5 Ingenuity pathway analysis of several candidate genes with oncogenic and tumor suppressing properties downstream of IFNG signaling 3458 3659 3553 7124 3665 6774 4792 6772 1029 4609 3394 6778 10379 6773 3537 4869 3620 10631 960 PMC7525004__F3 Genetic and pharmacological activation of Wnt/Beta-catenin promotes neurogenesis in the hippocampus of AD models 7473 89780 4040 4041 324 1499 100187761 2932 595 4760 PMC7527296__F1 IL-6-STAT3 signaling is a potential therapeutic target for COVID-19 mediated by cytokine storm 6774 7113 59272 6868 1839 1956 PMC7527411__F7 Proposed model of maternal combination exposed diet effects on cardiac network signaling in offspring 2475 2932 5468 PMC7528698__F1 Transcriptional regulation of macropinocytosis 2621 8205 558 PMC7530130__F28 Enzymatic Noncovalent Synthesis 7124 8737 8205 197259 PMC7530326__F1 TGFB signaling pathway 9573 2657 8200 2661 151449 392255 659 650 652 7048 654 27302 655 653 268 9210 10220 4838 93 4092 25805 4089 4090 4086 4087 4088 4091 51592 PMC7530326__F3 Dysregulation of BMP-ALK1-Smad4 signaling in HHTs 140805 7422 4089 5728 PMC7531435__F3 Integrins Control Vesicular Trafficking; New Tricks for Old Dogs 1601 8650 2060 387 PMC7532108__F7 Proposed pathway of recovery of R28 cells, induced by hPMSC-derived exosomes, after hypoxic damage 10054 2932 1499 PMC7532256__F2 Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside 930 3569 7422 361 727 PMC7532351__F4 Signalling Pathway Underlying PAK1-Blockers and Viral Infections 5728 59272 6347 5058 PMC7532371__F5 Red nodes are genes of CMTgset, and the green nodes are nonoriginal/extended genes 8776 9625 81846 25957 3308 8898 1410 26353 8079 476 3326 4744 3320 1956 84516 51164 23299 51199 10273 126393 132320 9500 22938 2885 22919 200728 PMC7532541__F8 AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway 174 355 841 8772 PMC7532973__F8 Schematic presentation of the mechanisms triggered by HAS3-induced EVs in target cells 960 3549 50846 3038 1950 2735 2736 PMC7533893__F3 Mechanisms involved in the aberrant activation of KEAP1/NRF2 pathway in cancer 4780 9817 2932 79728 10072 23552 100507436 PMC7545020__F3 An aberrant STAT pathway is central to COVID-19 9021 3716 6774 7297 10401 8554 1950 6714 1956 PMC7546314__F8 Cellular model summarizing potential mechanism of cucumber resistance to B 4015 2077 4609 PMC7546851__F1 Neutrophils in TME 3082 7039 2919 2920 6774 6374 7852 4321 4322 1977 1998 596 4170 9242 PMC7549271__F1 Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders 2581 410 7368 PMC7549330__F7 Diagram illustrating the molecular mechanism of LINC01315 in proliferation, invasion, and migration of OSCC cells 1741 102723775 4485 PMC7549355__F1 Hypoxia-inducible factor (HIF) and examples of long non-coding RNA (lncRNA) involvement 283587 5820 283120 100124700 102723099 378938 7428 2146 PMC7553623__F2 K-RAS pathway in cancer development 1950 3845 1956 PMC7554583__F2 mtDAMPs in cystic fibrosis Under stress, mitochondria generate and/or release immunogenic molecules, named mitochondrial damage associated molecular patters (mtDAMPs), that influence significantly the inflammatory response in CF lung disease 9217 7416 90550 58484 114548 22809 PMC7555718__F4 Osteoclasts and Microgravity 126014 6850 695 7006 100124696 4772 PMC7555769__F1 Canonical Hedgehog (HH) signaling pathway 6608 51684 596 2294 8842 PMC7555769__F2 Noncanonical HH signaling pathway 387 6010 6608 2475 PMC7555855__F1 Major targets of amino acids, peptides, and their analogs for the control of skin pigmentation 4157 2932 1499 4286 1638 7306 PMC7560080__F3 ROS and low-molecular-weight hyaluronic acid (LMWHA) involvement in both priming and activation of the NLRP3 inflammasome 7097 960 4615 114548 PMC7560597__F2 Interplay between the cGAS–STING signaling pathway and apoptosis 317 581 3661 115004 29110 PMC7560597__F4 Interplay between the cGAS–STING signaling pathway and pyroptosis 115004 9447 3553 PMC7560934__F1 Diagrammatic representation of Beta-cell function 6566 3098 2645 3172 776 PMC7564754__F4 How selected polyphenols can interact with p57 expression and activity (see and text for details) 1958 1028 5111 PMC7564814__F2 Intracellular cytoplasmic pattern-recognition receptor RIG-I is essential for the control of RNA virus infection 3454 3455 7297 7098 57506 6772 4615 7706 6773 10379 114548 3661 3665 PMC7564975__F2 Different ratios of STAT3A/STAT3B and their functions in therapy sensitivity 6714 6774 1956 PMC7565641__F5 Innate immune signaling pathways modulating BV transgene expression 115004 3665 57506 3661 29110 PMC7567487__F2 Mammarenavirus life cycle 7037 8828 2813 967 3916 80896 PMC7573490__F4 Interaction of Leptospira interrogans with the innate immune system 7100 7099 7096 7097 4615 114548 10392 64127 3553 PMC7575756__F8 Molecular mechanism underlying the tumor-suppressive effect of miR-766-3p in OS 4040 4041 2932 324 8312 1499 283149 PMC7576205__F6 Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma 3480 558 6194 3667 3717 2885 9846 2475 57521 6198 PMC7576986__F1 IFN-I induction and viral counteracting actions 7189 29110 3661 3665 51311 51284 7098 7099 54106 PMC7577395__F2 Representative contributions of ion channels to glioma cell proliferation 54822 55107 2475 PMC7581990__F1 Metabolic reprogramming is involved in malignant transformation of prostatic cells 2194 47 22917 65057 PMC7583816__F1 Diagram of proposed Pi-induced PP2A/Src/DAPK-1/TPM-3 signaling pathway 7170 1612 6714 PMC7583982__F1 Biogenesis and functions of miRNA 54487 29102 9924 255967 PMC7584388__F5 Mechanisms underlying T cell ageing 7535 940 27040 2475 2626 115004 10454 PMC7587925__F3 Kupffer Cells 7124 7189 3929 4615 929 7099 2002 PMC7591300__F1 Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19? 59272 5045 7113 PMC7591896__F1a Transcriptome analysis of chicken intraepithelial lymphocyte natural killer cells infected with very virulent infectious bursal disease virus 7124 3977 1896 5008 3624 6761 90427 4838 920 84957 PMC7593559__F2 AAI can activate TGFB/Smad-independent signaling pathways to cause abnormal cell proliferation 1956 7048 7046 2885 4087 4088 4089 3606 596 1543 1544 PMC7595122__F1 Caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer 8772 581 79792 637 838 837 834 836 842 3553 1687 PMC7595122__F3 Graphical model of the effect of various molecules on caspase-3 dependent tumor cells death 836 842 1687 PMC7595250__F2 Cellular signaling pathways involved in cell senescence in renal ageing 1021 1019 1017 23411 7483 2932 PMC7595665__F3 m6A modulators involved in cardiovascular disease and bioprocess 3082 7942 3184 79068 805 801 23214 PMC7596088__F3 Role of TGFB, IL-6, and IL-1B signaling pathways in PDAC EMT 8205 3553 6387 6364 PMC7597043__F1 Mechanisms of venetoclax resistance 958 613 6850 695 7157 596 4170 PMC7597592__F9 Proposed model of how TNFA and RIPK3 induce KC death following PH 3569 11035 8737 8772 6347 PMC7599628__F4 Initial immune response to any pathogen involves the activation of innate immunity 7096 7097 7099 7100 10333 81793 4615 3603 57506 51311 51284 54106 115004 PMC7600068__F2 Potential mechanism of radiation-induced abscopal effect 1956 472 3466 PMC7600801__F1 MAPK signaling pathway (A) in a BRAF inhibitor-sensitive cell showing sites of action of BRAF inhibitors and MEK inhibitors, and (B) after BRAF inhibitor resistance development 673 4763 5728 2475 4193 7157 PMC7600811__F12 Simplified representation of the canonical and non-canonical Wnt signaling pathway 5879 998 387 1499 PMC7601592__F1 Most important approaches to melanoma treatment 3815 940 673 PMC7602874__F1 Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signalling pathway 115004 5167 3661 29110 PMC7608616__F3 Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance 2932 5728 581 PMC7610305__F1 Upregulated AspH activates the Notch signaling pathway 444 960 4072 3516 896 5111 PMC7611834__F3 T regulatory cells as a potential therapeutic target in psychosis? Current challenges and future perspectives 7048 4087 4088 4089 6774 4092 50943 6097 PMC7640403__F4 Amino acid, energy and Wnt signaling to mTORC1 2932 652968 729438 7248 7249 2022 6009 3091 153129 64798 64223 2475 201163 57600 PMC7640965__F1 SARS-CoV-2 infection and proliferation process mediated by host and viral proteases 5340 5045 59272 7113 56649 PMC7641301__F7 Over-regulated pathway after 48 h Forskolin stimulation 7054 2353 3725 5339 7431 1938 4000 PMC7641865__F8 The protective effects of hPMSCs on CD4+ T cells senescence 920 2932 2534 2729 1728 847 PMC7643606__F1 NLRP3 inflammasome 114548 79792 3553 PMC7644630__F2 TBK1 and Innate Immune Signaling 115004 10133 29110 3661 57506 7098 5970 7099 4615 10010 8737 PMC7649120__F6 Scheme of possible pathways by which liposomes can “hit” PIM cells via C activation; example for the case of PEGylated liposomal doxorubicin (Doxil) and other PEGylated NPs 718 545 1380 1378 1356 PMC7649144__F1 DHEA is synthesized from pregnenolone through the Δ5pathway (red arrows) thanks the activity of the enzyme CYP17A1 412 1583 3284 1588 PMC7649190__F2 Hypothesis that vascular endothelial growth factor (VEGF) may promote T cell exhaustion and therefore Demodex proliferation, by analogy with what happens with tumors 7097 85480 3902 PMC7651136__F7 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer 1362 545 7508 1956 3146 7099 3661 PMC7655096__F2 Major signaling pathways during the process of osteoclast differentiation 54209 10326 126014 6850 2885 7006 100124696 695 4772 PMC7655627__F2 The mTOR pathway in liver cancer: from molecular genetics to targeted therapies 5728 5290 3845 673 7248 7249 1499 2752 4609 2744 6510 9057 PMC7657662__F3 Schematic depicting the complex II assembly pathway showing known mitochondrial disease genes in red and assembly factors in italics 644096 2242 54949 135154 57001 6390 6389 6391 6392 PMC7658535__F7 Signaling pathways induced by prolonged exposure to H 10392 3551 4616 329 604 4303 664 9140 PMC7662576__F4 Host targeted drugs with potential use for Coronavirus disease-19 and their proposed mechanism of action 920 929 2475 3716 3717 PMC7662794__F1 Risk factors/loci and associated cellular processes identified by genome wide association studies (GWAS) involved in Alzheimer’s Disease (AD) converge to the proteostasis network 1191 1378 10347 945 351 5663 5664 102 8301 2041 6653 274 PMC7664215__F2 Bioactivities and possible mechanisms of pterostilbene 2475 6774 6714 5879 3553 4318 4313 PMC7665122__F2 Signaling pathway induced by aPL 7099 4615 7189 7018 PMC7673857__F1 Main source of ROS and redox reaction 847 50507 27035 PMC7674767__F1 Extrinsic and intrinsic pathways to apoptosis 90427 572 638 8739 637 666 581 317 PMC7676225__F1 Metabolic effect of Wnt promotes the absorption of glucose in the neuron by increasing the affinity of the GLUT3 transporter for its substrate 2932 1499 324 7248 7249 51256 6009 2475 PMC7676225__F6 Caloric Restriction and Ketogenic Diet Therapy for Epilepsy: A Molecular Approach Involving Wnt Pathway and KATP Channels 2932 1499 324 7248 7249 51256 6009 2475 PMC7676498__F2 The Microenvironment in Controlling the Fate of Bioprinted Stem Cells 3082 1950 4087 4088 4089 1499 2475 PMC7682023__F5 Schematic depicting genes in the PLC signalling pathway 5336 23228 5330 PMC7683721__F7 Signaling cascade for the aberrant TRPV4 and calcium activation in endometrial cancer 5829 59341 387 6093 PMC7685213__F1 Simple Rx for congenital erythropoietic porphyria 211 212 3145 7390 5498 2235 7389 PMC7686704__F8 Wnt signaling in breast cancer drug resistance 1544 1559 1557 1576 1577 1555 1565 5243 9429 1499 PMC7687355__F8 Predicted activation of EGF and PDGF signaling after APAP300 compared to PHX at 24 hr 4609 1960 7538 595 891 6484 6241 1950 7056 388 5054 678 1959 7050 8061 2114 467 6659 PMC7688515__F2 AMPK-mTOR axis in the co-regulation of autophagy and immunometabolism 8239 3965 2475 2101 8408 3553 PMC7688918__F3 In response to I/R injury, neutrophils migrate from the circulation to the injured heart in response to CXCL and release S100A8/A9 2919 3579 6279 7099 4899 PMC7694477__F1 Hereditary hemorrhagic telangiectasia (HHT) and the transforming growth factor beta (TGFB) signaling pathway in endothelial cells 27302 2658 2022 659 4090 4086 4089 3397 PMC7695009__F3 Biosynthetic pathways of UDP-GlcA and UDP-GlcNAc 64841 5238 7358 6675 PMC7695578__F7 Schematic model showing the hypothesis for COVID-19 infection 59272 3716 7297 6772 6773 3717 PMC7696795__F1 Activation of JNK by proinflammatory cytokines TNFA and IL-17 leading to autoimmune arthritis 7189 7186 8717 PMC7697405__F2 Simplified schematic representation of the hyperactivated mammalian target of rapamycin (mTOR) signaling due to seizures 2475 7249 7248 6009 PMC7697568__F1 Wnt signaling pathway 147111 55366 8549 54894 324 PMC7697684__F3 New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance 5634 5631 65220 3099 5471 7086 2618 5223 790 5198 1723 10606 158 7372 471 8833 PMC7697917__F11 Enrichment of the neuroinflammatory pathway in microglia in cluster 1, based on the DEGs between cluster 1 and clusters 2–5 146433 7124 1431 3665 338376 3569 3565 1401 4137 PMC7698114__F2 Difference of two variants of CDK20 23552 902 30819 23557 1017 PMC7698658__F5 Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds 2305 1063 9212 374 1062 3569 332 701 51284 3603 7186 7430 22944 6348 8318 PMC7699575__F1 Ferroptosis pathway 2879 8031 2182 10162 6520 PMC7699852__F4 Deleterious effects of aryl hydrocarbon receptor (AhR) activation in asthma 196 85480 3576 PMC7699912__F1 Toll-like receptors (TLR)-mediated signaling pathway in keratinocytes 4049 929 7100 7099 7097 10333 7096 3661 54106 7098 3665 PMC7700615__F2 Signaling via TGFB receptors initiated at different intracellular locations and sites of inhibition by RAC1B 4092 6714 1601 64750 57154 4089 4087 4088 7018 PMC7701218__F9 Proposed CCN3-mediated signaling pathways in placental diseases PE and AIP 4851 1019 1017 907 PMC7705115__F1 Novel components of the JAK2-STAT5 signaling pathway 50624 8835 3717 PMC7705115__F4 Crosstalk between JAK2-STAT5 and hormone receptors, growth factors, inflammatory cytokines, and integrins 2066 3717 4087 4088 PMC7709275__F3 MiRNAs regulate tumor characteristics including apoptosis, invasion, EMT, and metastasis by regulating the UPR 3146 7991 407009 22926 83939 3725 468 6935 6615 724027 27074 9518 11160 PMC7710624__F7 Genetic and Physical Interaction Mapping Reveal New Facets of RAS Pathway Biology 3265 4893 3845 5898 5899 55698 5910 387 PMC7710690__F2 PD-1 and PD-L1 interactions and mechanism of T cell inhibition 324 2475 941 942 940 3932 7535 5335 5728 10538 3558 PMC7714782__F3 Metabolism of methionine in viral infections of hepatitis B and C 4144 4143 3276 619501 6772 8554 PMC7716140__F1 Figure shows the pharmacological effects of ulinastatin 7099 4615 581 920 PMC7716721__F4 SFN-induced ferroptosis pathway 23657 2810 2879 PMC7720970__F1 Revisiting Hormonal Control of Vascular Injury and Repair 2736 2735 6608 8643 5727 PMC7722523__F1 Molecular Pathway Activation Downstream of BCR-ABL1 6608 3717 613 2885 1399 9846 1499 2475 2735 PMC7723503__F8 Signaling pathway of CaOx-induced ferroptosis in HK-2 cells and rat renal tissues 7018 2879 2182 6520 23657 PMC7723564__F7 Primary mechanism of PRP improves chronic inflammatory pain 3146 6774 2670 PMC7725436__F3 Venn diagram of differentially expressed genes 3479 2100 7124 7040 1869 2099 3725 6774 6667 3091 2353 4792 4609 9314 860 PMC7725871__F2 TLR4 signaling pathway: TLR4 is localized on the cell surface for ligand recognition, some of which are recognized after TLR4 interacting with MD2, even requiring CD14 and/or LBP involvement 3146 7099 3929 929 4615 2475 PMC7730007__F8 Mapping the S1P-S1PR1signaling pathway in differentiated SGBS and 3T3-L1 adipocytes 56848 6610 23236 208 5330 10000 5596 5598 PMC7730528__F4 Prolidase induces EGFR-downstream signaling pathway 4827 1956 2475 2597 PMC7730528__F10 Graphical illustration of prolidase-dependent EGFR, B1-integrin receptor, TGFB1, and IGF-1R-downstream signaling 1956 3480 6714 126669 2885 50964 2475 PMC7730698__F2 Role of CK1D/E in the Wnt signaling pathways 4041 4920 4919 4040 6259 2932 1499 4609 22943 50943 PMC7733318__F8 Proposed working model 4088 4089 5678 6935 51129 7048 7046 PMC7733924__F6 Predicted pathways might be involved in the interaction between CSFV p7 and host cells 51371 7416 22919 9318 8554 79893 PMC7734287__F8 Mechanism for Forkhead box Q1 (FOXQ1) induced angiogenesis and macrophage infiltration in colorectal cancer (CRC) tumorigenesis 1950 5329 94234 1839 51129 285 284 7006 100124696 7291 6347 PMC7734567__F2 Mapping the 12 pairs of genes, which are positively correlated in all 12 types of cancer, into the tryptophan metabolic pathway 316 11185 847 1962 1738 2639 1743 39 3030 55526 PMC7737552__F2 Huaier inhibits cell proliferation and metastasis by upregulating DARC and downregulating its ligands 1000 999 648 10413 PMC7738626__F2 IFN-I response and signaling pathways in malaria parasite infections 50808 64135 2821 84868 54625 92797 85441 29967 7099 7096 3454 23586 7297 115004 3717 3631 3455 54106 57506 4615 6772 6773 7187 8061 7189 10379 29110 64108 3661 958 PMC7738964__F3 Peroxisome proliferator-activated receptor (PPAR) signaling pathway in the MetaCore analysis 30 6256 8310 1374 1375 34 1376 3030 PMC7746447__F2 TRPV2 regulation is involved in cellular responses relevant to cancer 3630 3479 51393 PMC7746484__F1 Toll-like receptor (TLR) signaling pathways 7100 7097 7096 10333 7099 7098 51284 54106 114609 4615 51135 3654 3656 7187 3661 3665 PMC7752075__F2 Synthetic pathway of NO in ECs, inducers, inhibitors, the roles played and the effects of different components of the ECM 948 961 6714 PMC7752859__F15 The immunomodulatory activity of Ligilactobacillus salivarius TUCO-L2 isolated from llama (Lama glama) milk in porcine intestinal epithelial (PIE) cells 929 7099 4615 59307 51135 54472 3654 3656 7189 3725 2353 3553 6355 4283 6374 3627 3576 6373 PMC7758733__F7 Proposed signal transduction pathways by which quercetin induces apoptosis in AML cells 3479 596 581 2475 PMC7759768__F3 Major sources of oxidative stress in Parkinson’s disease and the corresponding antioxidant defense mechanism in dopaminergic neurons 7054 4827 2670 759 1810 572 581 836 842 PMC7760926__F1 Role of oxidative stress in muscle wasting during cancer cachexia 468 3479 2475 3726 PMC7761761__F8 Putative metabolic pathway for the production of derivatives of nitrogen-containing azaphilone red pigments in the marine-derived Talaromyces sp 762 3009 1442 PMC7762580__F1 Fructose and glucose degradation pathways 6652 231 2821 229 226 230 PMC7762580__F2 Fructose contribution to the pentose phosphate pathway 6652 231 3795 2821 7086 229 226 230 6120 PMC7763058__F1 TGFB signaling in fibroblasts 4087 4088 4092 6010 3985 4089 PMC7763898__F2 MicroRNAs expressed in periodontitis and their target in alveolar bone 4774 27250 4286 387 9935 PMC7764362__F4 Main action mechanisms of chloroquine (CQ) and hydroxychloroquine (HCQ) related to antiviral and immunomodulators properties 1636 7098 54106 51284 3661 3665 6772 10379 PMC7764600__F2 Most important signaling molecules characterizing EBV + GC 8289 1956 1950 2475 5728 3082 283248 1029 PMC7765317__F2 Nuclear factor-E2-related factor-2 (NRF2) pathway exerts antifibrotic effects 847 1728 2729 PMC7765584__F4 Gene network interaction of cancer stem cell signaling pathway in (A) LNCaP cells and (B) C4-2B cells with and without enzalutamide treatment 3977 4609 6300 8321 83729 3399 8322 3845 5600 PMC7765927__F2 Suggested interaction model between EBV and P 7097 4318 6374 4313 2919 2475 PMC7767764__F1 Lipofuscin and drusen in the RPE 50700 545 6120 PMC7767789__F3 Metabolic abnormalities induced by hyperglycemia 367 2597 3479 PMC7768132__F3 Regulatory mechanism of KRT19 expression in HCC 1950 3082 5156 1956 85451 6714 3880 3725 PMC7768820__F4 Underlying mechanism of Paeonia lactiflora P 3569 7124 135 1813 841 836 6531 842 1812 596 5743 PMC7769200__F8 Schematic model illustrating the biological roles of the hsa_circ_0000714/miR-370-3p/RAB17 regulatory axis in A2780/PTX paclitaxel-resistant ovarian cancer cell 64284 1019 1021 PMC7772217__F3 Role of the inflammasome complex in modulating immune responses in a Toxoplasma gondii infection 114548 22861 834 4280 2633 6850 64170 10892 841 PMC7773148__F1 Fatty acid and endocannabinoid metabolism by cytochrome P450 classes 1558 1559 1573 66002 4051 8529 PMC7773746__F1 Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway 378938 581 596 PMC7774741__F1 Flow chart for selecting SNPs in retinol metabolism pathway genes 4094 216 220 PMC7775142__F5 Synthetic gene circuits for self-regulated drug delivery systems 11096 3627 3569 6347 914 PMC7775270__F4 Musicians in the intrinsic pathway of apoptosis—a large ensemble 2932 10628 8739 581 PMC7779984__F2 Omega 3 Fatty Acids and COVID-19: A Comprehensive Review 10454 7189 7099 4615 PMC7780193__F3 Cell Energy Metabolism and Hyaluronan Synthesis 7040 7124 3553 3037 107966124 6667 1385 7528 6935 23411 PMC7780621__F3 Role of cytokines/chemokines on tumor progression and dissemination 1236 4582 7422 7424 7852 3579 6387 PMC7781009__F1 MET oncogenic activation 3082 867 7175 3123 5803 83930 7982 PMC7781229__F1 Mechanism and function of therapy-induced senescence 6839 545 472 5371 1021 1019 PMC7782086__F8 Graphical abstract illustrates the function and regulatory mechanism of FOXD1‐AS1 in AGS 100423038 106144539 5290 5266 2475 1977 2297 PMC7790891__F1 Regulatory mechanisms of ginsenosides in HUVEC 4015 5925 9817 581 7412 3383 PMC7791639__F7 Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFBR1/Smad2/3 pathway 4314 11096 9242 1277 2335 7046 1281 4087 4089 4088 4322 595 PMC7792119__F9 Schematic diagram for the functions and mechanism of linc00887 in regulation of cervical cancer 100131551 122786 9113 26524 4485 PMC7793647__F2 Major signaling pathways of GILZ 2309 3725 130749 7124 3569 3553 2638 PMC7794017__F1 Canonical and non-canonical WNT pathways 1499 4041 6259 4040 324 2932 387 4316 595 4609 PMC7794837__F1 Altered Ca2+signaling in T cells during aging—impact of ion channel expression and function 84876 54822 7535 7226 54795 50943 3558 PMC7796211__F1 P53 network and metabolism 1877 648 4193 4194 PMC7796211__F3 Several metabolic pathways in which the different components of the p53 network are implicated, including glycolysis, Oxphos, amino acid, and fatty acid metabolism 4193 1877 4194 648 PMC7796309__F1 Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease 3045 100187828 23621 759 735 PMC7796410__F2 Peptide-Based Nanomaterials for Tumor Immunotherapy 4478 960 2669 PMC7801281__F3 ROS production mediated by diverse signaling pathways 80221 1431 10162 2182 2879 2746 4015 PMC7802795__F13 Possible mechanism of anticancer activity of SnO2-ZnO/rGO NCs 594857 836 847 PMC7804279__F1 The Hippo pathway in the pathogenesis of inflammatory bowel disease 4771 5784 9113 26524 9686 PMC7804279__F3 The Hippo pathway in the pathogenesis of inflammatory bowel disease 6774 4087 4088 50943 4485 PMC7807718__F6 Scheme summarizing the inhibition of H2O2-induced oxidant injury by FPNP via the up-regulation of antioxidant enzymes and TGFB/Smad pathway 847 2271 4087 4092 2006 PMC7812220__F8 Protein-protein interaction network of hsa-miR-126-5p-related differentially expressed genes 6330 9353 1832 4239 100820829 132203 4969 361 4311 2012 120892 2328 4322 64407 3977 4319 10203 1910 59350 7538 60675 2191 54873 7099 8676 5473 53829 26575 2274 5743 2706 9590 10365 5225 8796 56649 6401 64321 5787 64151 8972 2294 51705 761 2525 161198 3161 858 83879 9833 9928 200504 54443 PMC7812236__F1 Notch signalling pathway 9794 23462 3280 4609 PMC7814174__F3 GDF15 and FGF21 as mitokines in the diurnal regulation of energy balance 26291 3258 9575 23237 4922 9518 PMC7815509__F1 Oligodendrocyte lineage cells and depression 10215 6663 29117 5091 5156 4851 4099 4340 4155 PMC7817106__F7 Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation 6657 3066 6663 100 PMC7817765__F1 Activation pattern of NF-KB pathway in lung cell lines infected with SARS-CoV-2 367 6955 4397 5879 4790 7097 10000 3663 51135 3551 5604 2353 23118 929 1432 7098 329 4049 3725 PMC7818013__F1 DNA double-strand break repair pathway choice: a new focus on 53BP1 9656 9025 165918 472 4200 55183 PMC7818425__F6 Selected features and functions 169792 10745 23118 387082 26191 3586 1512 3559 3575 8935 PMC7819155__F2 Roles of the lncRNA H19 in osteogenic differentiation 283120 100033819 406933 5747 1499 4088 860 PMC7820501__F4 Summary of the molecular processes during COVID-19 infections that are affected in DS 7113 5045 59272 6772 684 9510 6041 6035 3586 3627 PMC7822913__F7 Hypothetic model of Abcc6 function in cholesterol homeostasis of mice 4023 255738 348 3652 2224 4047 3931 5244 8647 PMC7825156__F6 Metabolic disturbances in PD 1581 1593 80270 2170 9420 1733 4015 25801 PMC7827341__F2 IL-1A signaling pathway 51135 4615 3654 3656 7189 PMC7827610__F1 Haem biosynthetic pathway and associated porphyria disorders 210 3145 9049 PMC7827855__F1 Interplay between the Hippo, Wnt and ARF/p53 signaling pathways in development and tumorigenesis 472 4485 4193 324 9113 26524 2305 PMC7828702__F11 TGF-Beta-related oxidative stress signaling pathway in HTMCs (created in BioRender.com) 4087 4088 4089 4092 PMC7828713__F2 Microglial regulation of neuronal networks and CNS homeostasis 8205 627 1524 PMC7830527__F2 Proposed IFN-Gamma-dependent mechanisms of hyperprogression 3620 7099 7474 114548 6374 3579 355 PMC7831909__F2 Sulforaphane targets Nrf2 pathway to prevent kidney disease progression 9817 1645 1728 7412 PMC7833428__F4 Extracellular PEPD induced expression of the B1-integrin receptor and IGF-1R signaling proteins in control and “scratched” fibroblast models 4827 5184 3480 2885 2597 126669 PMC7833977__F9 Interferon stimulating genes (ISGs) in the pathway 4940 9636 3665 818 4599 3455 3460 7297 3716 3717 6773 10379 PMC7835216__F2 Emerging functions of branched ubiquitin chains 51366 83737 10628 324 PMC7836194__F2 Curcumin mediates miRNA regulation in PC 5728 595 55102 27022 1499 1789 1786 1019 PMC7842749__F8 Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease 3064 4478 361 PMC7844014__F6 Network of interactions significantly enriched for genes displaying altered methylation patterns following treatment with valeric acid 84248 57693 8449 7919 2287 140890 3608 6294 6427 55054 5546 4343 2342 6016 10013 9140 4678 4582 51112 3161 122553 5784 2059 29119 10314 PMC7844024__F8 Differential NFKB pathway activation by 65–79*SE and 65–79*PE under M1 (A,B) or M2 (C,D) polarizing conditions 6774 5971 7157 4609 1958 1050 6772 7006 100124696 6667 5970 5966 4792 3659 4790 3091 PMC7847648__F4 PPI network construction revealed the most significant modules, and signaling pathway enrichment analyses were conducted for the module genes 55215 9232 8318 23397 54892 7298 891 332 9319 55839 1062 1033 55355 2305 PMC7847682__F1 External and intrinsic mechanisms to mediate immunotherapy resistance for CSCs in HCC 619501 1499 324 6364 961 PMC7849831__F2 Mitochondrial dysfunction in astrocytes contributes to neuroinflammatory activation of astrocytes 115004 114548 65018 PMC7851346__F8 URA-mediated EAE Mitigation by Directly Targeting Aryl Hydrocarbon Receptor 3717 196 1437 PMC7851442__F2 DCs in cancer therapies 4283 3146 3627 11277 5027 958 2833 7099 7098 2322 115004 114548 2323 PMC7855621__F2 Centriole and cilium biogenesis 22897 132320 85302 26005 84902 51134 PMC7857696__F1 Natural and synthetic mucin-type O-glycosylation pathways 717 718 56913 6761 55808 PMC7861567__F5 Mild hyperandrogenemia in presence/absence of a high-fat, Western-style diet alters secretory phase endometrial transcriptome in nonhuman primates 7157 6934 6925 4088 5933 367 595 1874 79923 2101 4609 2146 4303 3725 84449 149483 PMC7862491__F2 Expanding the role of proteasome homeostasis in Parkinson’s disease: beyond protein breakdown 9817 23304 4899 84301 3716 3717 6772 3659 PMC7862610__F6 Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population 7124 1431 1401 PMC7863362__F4 Compared with photoautotrophy, the expression changes of photorespiration biosynthesis pathway in mixotrophy 3250 283871 189 PMC7864012__F1 Serine-glycine biosynthesis pathway 26227 29968 5723 PMC7864232__F7 Diversity and Biology of Cancer-Associated Fibroblasts 6469 6608 5727 PMC7866084__F1 NLRP3 inflammasome activation in AD and PD with potential intervention of natural extractions 948 7097 7099 2534 4615 114548 PMC7867045__F3 Genetic alterations leading to HIF activation in GB 1950 5728 4193 1956 PMC7867545__F10 The Impact of the CMT2B-causing RAB7 mutant protein on the endocytic pathway 7251 3916 3920 1509 1514 1508 PMC7868042__F2 Autophagy in kidney homeostasis and disease 65018 664 665 139341 4077 10537 PMC7868826__F4 EGF induced A20 expression via the MEK1/MSK1/p-p65 (Ser276) signaling pathway 7124 1950 2597 PMC7877184__F8 Morphine-3-glucuronide (M3G) promoting non-small cell lung cancer (NSCLC) immune escape via toll-like receptor 4 (TLR4) and programmed death ligand 1 (PD-L1) 7099 929 4615 PMC7878452__F1 Glucose metabolism in the brain 2821 5209 2597 PMC7878551__F6 Hypothetical model for Gram-negative bacteria induced major innate immune response in horseshoe crabs 3929 2 4615 PMC7879558__F1 NHEJ and antiviral innate immunity 7808 3661 3665 29110 PMC7879595__F2 Among P2X receptors, the P2X7 is highlighted within the context of BC 999 1499 960 8178 PMC7880315__F8 Working model of Beta-elemene and RT on tumor growth in NSCLC cells 999 960 1000 PMC7881399__F6 Action relationships including activation (green), inhibition (red), expression (yellow), and binding (blue) between the genes which were related to the determined biochemical pathways 213 7124 7157 3576 1956 3630 4586 7422 9370 PMC7882924__F9 Graphical illustration of the function and mechanism of miR‐144‐3p in combination with hBMSCs 595 1019 999 PMC7892431__F3 Dysregulation of nucleic acid-induced signaling during HCC development 619501 7098 9447 115004 834 6772 3627 1950 PMC7892976__F2 Se transport across blood–brain barrier (BBB) and blood–cerebrospinal fluid barrier (BCB) 6414 7804 8991 9403 2879 6415 PMC7897492__F6 Working Model 828 9149 254225 3014 11201 PMC7898445__F8 Signalling pathway of Eno-RPSA induced the loss of BBB integrity 3329 1977 7099 3921 PMC7898550__F9 Schematic diagram describing the mechanism in the inhibitory effect of PQS on NR inflammatory injury 7099 114548 4615 5662 PMC7905242__F4 “瓜蒌-甘草”药对化学成分（）-靶点蛋白（）-信号通路（）网络Chemical components ()-target protein ()-signal pathway () network of "Trichosanthis fructus-Glycyrrhizae radix et rhizoma" drug pair 3949 2147 3558 5327 2152 1991 7068 790953 6462 9429 695 5914 1557 PMC7913835__F3 Protein–protein interaction network between gene products with high-impact variants contained in the top enriched pathways and those presenting differentially methylated sites in CLZ-treated patients 8911 3760 27445 6263 6262 6833 3778 3782 3781 5592 3763 55811 3710 9882 10000 2778 115 57468 5335 5579 2557 108 5578 7157 2893 2559 200959 2567 7068 9228 6256 6258 3690 7804 10499 338 9862 PMC7915065__F2 Key mechanisms underlying resistance to PD-L1 (1) 3579 7474 114548 3716 941 942 3902 940 11148 7528 PMC7915726__F1 The Mer receptor tyrosine kinase (MERTK)-mediated signaling pathway in epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI) resistance 1956 3084 3082 5627 7287 1950 10461 6714 6657 6935 6774 6778 2475 PMC7916216__F2 Direct and indirect effects of radiotherapy, chemotherapy, and protein kinase inhibitors on NK cell activity 58191 3135 673 2932 8205 80328 100507436 PMC7917554__F3 Pyroptosis 838 837 114548 834 3553 PMC7918730__F3 Clock and mTOR pathway interconnection 7249 2475 9575 406 PMC7919658__F3 Oxysterol and BA profiles by the hepatic endocannabinoid and immune system in male mice 2264 4615 9420 1593 1582 1581 8213 PMC7919800__F1 Insulin-like growth factor (IGF)/IGF-1R signaling pathway in the development of liver disease 3479 3481 3480 8205 619501 PMC7920043__F1 Schema of “signaling” pathways for CS effects 1956 4087 4090 4088 4089 PMC7920285__F1 The differences in the localization of the upstream regulators and the core cascade components of the Hippo signaling pathway during murine and bovine embryogenesis 154796 4771 10413 PMC7922891__F6 Graphical summary of human skin fibroblast profiling of SS patients 652 56300 650 7097 4973 10672 148022 PMC7923230__F6 New Gene Markers Expressed in Porcine Oviductal Epithelial Cells Cultured Primary In Vitro Are Involved in Ontological Groups Representing Physiological Processes of Porcine Oocytes 290 6523 4015 1382 50507 2331 7070 5055 55601 29126 3620 9388 10628 3690 8910 1278 1990 10468 146862 7436 PMC7923882__F13 Mechanisms for poly(dA:dT)-mediated HSV-2 inhibition in human cervical epithelial cells 3454 3455 3587 7297 6772 6773 23586 6774 9636 4939 4938 115362 3661 3665 PMC7923894__F2 Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson's Disease 2638 7097 7099 942 361 PMC7924631__F2 IRS acetylation by abnormal cytoplasm-appearing P300 causes insulin resistance 3630 3667 8660 2308 200186 PMC7933196__F1 Berberine on diseases by regulating intestinal flora 7099 4615 948 929 PMC7933526__F10 Mechanism underlying renal-protective effect of QYDP 4087 4088 1499 4089 7018 PMC7933973__F1 Current mechanisms underlying KLF5 effects on kidney diseases 4018 5879 1786 10413 1958 718 688 6279 6280 595 1019 55294 PMC7934421__F1 Molecular pathomechanism of CRP-mediated damage in ischemic or hypoxemic tissue 5091 1401 2271 720 718 721 717 PMC7936150__F6 Heme and protoporphyrin IX biosynthetic pathway 2235 22 210 7390 10058 292 7389 PMC7937695__F1 Three kinds of inflammasome pathways associated with pyroptosis 8772 79792 1687 PMC7940844__F1 Toll-like receptor 9 (TLR9) signaling pathway(s) upon CpG oligodeoxynucleotides (CpG-ODN) stimulation: CpG-ODN is internalized through endosomes where it interacts with the endosomic domain of TLR9 7099 54106 3661 3665 3553 PMC7946999__F3 Different redox state between naïve CD4+ T cell and synovium in rheumatoid arthritis 920 2539 5209 PMC7947908__F4 Insights Into the Involvement of Circular RNAs in Autoimmune Diseases 970 1378 1786 51071 PMC7949100__F1 Central role of AR signaling in prostate cancer and targets in CRPC 1586 367 8644 1022 5469 PMC7952990__F1 Oxidative stress leads to impaired GR function through proinflammatory signaling 85480 90865 3603 4703 6774 196 PMC7956893__F1 Molecular anticancer mechanisms of PPs 355 2932 1499 378938 6774 3569 PMC7956893__F5 PPI induces protective autophagy through the PI3K/AKT/mTOR pathway by inhibiting AKT (S473), mTOR (S2448), p70S6K (T389), and 4EBP1 (T37/46) and increasing the conversion of LC3I conversion into LC3II 1950 2475 253260 PMC7956994__F1 Complement system with focus on most relevant targets for therapeutic inhibition 1401 5806 2271 718 720 717 721 1378 729 735 966 730 27202 PMC7957490__F1 Crosstalk between MSCs and immune cells in the initial phase of tissue injury 100187761 6347 6348 2920 9242 6352 6387 4282 PMC7961896__F2 Unfolded protein response (UPR) pathways in skeletal muscle 7186 22926 83939 468 PMC7962935__F1 Downstream signaling of Frizzled proteins (Fzds) 4041 4040 324 2932 1499 6010 PMC7963155__F4a MicroRNAs in the Cisplatin- and Radio-Resistance of Cervical Cancer 60674 5728 255082 PMC7965852__F2 LncRNA-mediated lineage transition 3479 3082 7039 2621 6387 596 1950 1839 378805 55000 3480 2146 221883 283932 283120 5978 400550 347689 283131 100499467 378938 100128262 5055 8205 1000 PMC7967180__F1 The leukotriene signaling pathway 4050 4049 2840 PMC7968000__F3 Tumor suppressive role of HNF4A 6868 1499 7088 6925 595 899 655 2521 6418 6241 1026 PMC7968373__F1 Swimming towards solutions: using fish and frogs as models for understanding RASopathies 2885 161742 4763 867 8216 22808 8036 PMC7970116__F2 Bidirectional Relationship between targeted therapies (VEGF/VEGFR inhibitors) and TIME in ccRCC 2247 3383 3579 6347 729230 7852 6387 PMC7971547__F3 Role of inflammasomes/pyroptosis and PANoptosis during fungal infection 4615 64170 3659 81030 114548 3553 9447 PMC7971890__F8 JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination 57506 7187 3661 6048 23210 29110 PMC7974894__F7 Identification of Prognosis-related Hub RNA Binding Proteins Function through Regulating Metabolic Processes in Tongue Cancer 6418 50943 3953 3091 5213 1588 PMC7979572__F3 Stress, Nutrient and Growth factor signaling pathways that affect translation 1998 2475 29904 3479 1938 1977 6194 1975 3492 PMC7981598__F5 Description of 3 overlapping-pathways for complement activation: The complement: opsonin C3b, anaphylatoxins C3a and C5a (complement peptides), and membrane-attack complex (MAC, C5b-9), produced by all three pathways 718 717 727 PMC7984363__F2 HIF regulation and function on POMC 7124 181 7249 7248 6009 4160 1977 5443 4852 7428 PMC7985098__F1 Roles of NLRPs and TLRs pathways in atherosclerosis pathophysiology 9973 4015 4615 114548 PMC7985549__F1 Several ligands on the cell surface stimulate the production of PIP3 (phosphatidylinositol trisphosphate) by PI3K 1956 5728 2932 324 1499 PMC7986633__F4 Proposed model of how deflavination of ACAD9 by ECSIT permits the coordinated regulation of the FAO and OXPHOS pathways 51295 28976 51103 1283 717 PMC7987945__F6 Transcriptome Analysis of Ovarian Follicles Reveals Potential Pivotal Genes Associated With Increased and Decreased Rates of Chicken Egg Production 3754 2560 4726 4706 782 374291 4722 126328 2566 2567 4724 4718 4715 4716 2562 2564 2561 80896 1740 1741 27292 1739 728294 4685 1742 55120 4684 5621 6181 9320 347731 2961 PMC7988757__F5 Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension 2255 10253 7249 7248 6009 PMC7988785__F1 An update on brown adipose tissue biology: a discussion of recent findings 84818 7045 2251 2254 26291 9547 PMC7989705__F2 Solute carriers (SLCs) associated with PDAC cell proliferation, angiogenesis, invasion, and metastasis 11254 6520 55630 23657 6774 3569 2475 94241 26524 960 PMC7991784__F1 HBV-induced lipid metabolism changes in hepatocytes 335 345 55937 6611 3949 3156 7038 5465 1581 116519 355 6319 2180 PMC7996181__F9 Mechanosensing by the nucleus 207 6714 4000 PMC7998562__F1 Complement activation pathways 5066 8726 718 2271 720 717 1604 721 4179 727 966 729 3630 730 735 PMC8000236__F7 Top predictive features for IGHV-mutated CLL patients 2475 998 3577 5465 PMC8000936__F4 DDX11-mediated regulation of EZH2-p21 and PI3K/AKT/mTOR signaling pathways in HCC cells 2146 1869 1663 2475 PMC8001022__F2 RAGE structure and signaling pathway 3146 717 1729 114609 4615 51284 54106 PMC8003205__F2 CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 screens identified genes involved in Gb3 biosynthesis, with a schematic diagram of the Gb3 biosynthesis pathway and a summary of the top genes identified in CRISPR/Cas9 screens 2531 196 7357 9334 53947 9741 7355 55858 9375 PMC8003318__F3 miR-29a as an epigenetic modifier 174 9869 55384 1788 80312 200424 54790 8651 4318 PMC8003318__F6 miR-29a as a regulator of tumor microenvironment 4017 6774 9076 7422 5155 6091 10410 619501 3480 PMC8006293__F9 Depletion of CX3CR1 leads to increased activation of the necrosome in PMNs 3577 1378 11035 197259 90865 7099 3146 PMC8010074__F9 Craniofacial Development: Neural Crest in Molecular Embryology 960 1277 860 6662 6660 249 248 1749 1499 55553 50964 6657 1300 1280 4322 PMC8010917__F2 NLRP3 activation pathway 4615 114548 140609 3553 PMC8011326__F3 Shh pathway regulated by MID1 4281 6469 5080 652 PMC8014301__F1 The SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection 9118 1901 9294 1903 8698 6010 53637 1901 9294 1903 8698 53637 6010 PMC8014352__F5 Potential pathway of IGFBP-1 in the present review 3484 3667 5728 6714 7546 7025 2475 5241 PMC8014382__F1 Tumor cell and T cells: the pathways that involve MDSC cells, CD8+ T cells, Tumor cells, NK cells and chemotherapy drugs were constructed 7422 324 3815 5979 PMC8014382__F2 APC cells and T cells: the pathways that involve OX40/OX40L, PD-1/PD-L1, mTOR/Akt, NKKB/NFAT and Cyclin A/CDK were analyzed 324 3565 10538 55509 51547 23411 2475 50943 PMC8019700__F2 Human rhinoviruse (HRV) replication and inflammatory response 3383 222256 3949 3603 3569 PMC8024119__F5 Enhanced activity of the RAS-MAPK signaling pathway due to the loss-of-function mutation of the NF1 gene and mode of selumetinib action 2885 4763 5894 673 PMC8025242__F3 Metabolism-modulating activity of IL-17 signaling in health and disease 10365 51274 28999 7350 90865 6761 PMC8026084__F9 IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling 2146 1108 3550 84444 PMC8026474__F2 Simplified overview of PRR signalling pathways in gastrointestinal epithelial cells 7099 7097 7100 54106 4615 64127 171389 80216 92610 22861 7189 3603 7098 7096 PMC8027318__F2 Proposed model of signaling crosstalk for the BCR to induce CSR 613 958 6850 7187 7186 695 4615 5336 5970 5971 57379 PMC8027411__F9 RAB31 marks and controls an ESCRT-independent exosome pathway 11031 967 254272 23102 PMC8027653__F1 BAP1-mediated malignant signaling 3054 8314 1869 5933 890 993 595 898 3710 PMC8029610__F2 CGAS–STING pathway as a therapeutic target in inflammatory diseases 55364 115004 29110 3661 581 6573 5167 324 PMC8033456__F1 STING and transplantation: can targeting this pathway improve outcomes? 3661 115004 29110 324 1493 961 PMC8034148__F2 Regulatory mechanism of necroptosis 8717 197259 1540 8737 8772 11035 PMC8037234__F5 E2s participate in the NFKB pathway 7124 4055 958 8717 613 7334 7189 7335 1540 5971 7187 7186 7188 PMC8038661__F2 Extracellular regulators of adipogenesis 650 89780 4851 6469 2638 1499 2737 2736 2475 4086 2625 2624 3170 6932 4089 PMC8039187__F7 Findings in the study 6742 2271 7019 5428 11232 4536 4541 4538 PMC8039377__F1 Molecular cascades that create epigenetic memory in HSCs 3553 3661 3458 7099 7098 3717 204 3716 6850 4615 115004 472 11277 3569 19 4356 5978 11035 PMC8040309__F3 FGL1-involved signaling pathways 2267 3717 6774 3902 142 2475 619501 PMC8040477__F4 Epidermal growth factor receptor (EGFR) signaling pathway and potential mechanism of resistance to cetuximab and panitumumab 1950 7039 1839 3082 2621 1956 558 1969 4318 2475 PMC8041205__F8 TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88 7321 4615 7189 PMC8042134__F3 Factors produced in the obese breast microenvironment contribute to the growth of breast cancer 7124 3570 3717 2475 6774 PMC8042276__F4 Epigenetic Modifiers: Anti-Neoplastic Drugs With Immunomodulating Potential 920 2146 23135 3065 79885 1788 2625 8320 30009 3458 50943 4087 4088 3605 23411 10014 54790 108348016 PMC8044581__F10 MicroRNA-1297 suppressed the Akt/GSK3B signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model 2932 581 5728 PMC8045279__F1 Leptin signaling pathways 3717 9021 2885 6774 5091 4852 181 5443 PMC8046990__F9 NAD+-SIRT1 signaling fine-tunes the activity of key transcription factor networks to promote adipocyte function 23411 23057 64802 4314 1291 4322 3910 3915 7052 3934 6720 4696 4709 4711 4712 4714 2919 3627 3557 2940 PMC8047069__F2 Life Cycle of the Phagosome 8411 5266 55207 PMC8050350__F5 Metabolic Signature of Autoreactive T cells in Rheumatoid Arthritis 5209 2539 8801 159963 PMC8052137__F6 Underlying Molecular Mechanisms Involved in Traditional Chinese Medicine Smilax china L. for the Treatment of Pelvic Inflammatory Disease 5241 1244 9356 5743 4353 1576 213 6774 4318 4313 5243 3558 5329 3329 7124 3934 1508 PMC8052259__F1 m6A regulates innate immune signaling pathways 51441 3661 57506 29110 4615 7099 7124 PMC8058381__F7 Fubaiju protected ARPE-19 cells oxidative damage by activating PI3K/Akt mediated Nrf2/HO-1 signaling pathway 581 2729 1728 PMC8058998__F1 Phosphorylation events in TLR signaling 695 51135 3654 7189 7187 8737 29110 3663 3665 3661 4118 4615 3656 23118 10454 PMC8061373__F1 Schematic hypothesis of the proposed mechanisms of TLR3 derived from SARS-CoV-2 leading to hypertension 59272 7098 29110 11171 3661 PMC8062309__F1 Local and systemic complement activation in preeclampsia and healthy pregnancy and complement-modulating medications 718 715 716 717 4179 3075 3426 1604 727 3078 966 PMC8065646__F3 Examples of redox regulation of specific transcription factors 3651 9817 5078 5080 PMC8066409__F1 Transcriptional and non-transcriptional activation of IRF3 by virus-activated signaling pathways lead to host antiviral response 7098 83939 1956 57506 6714 7187 3661 581 29110 115004 1499 7186 PMC8066409__F2 Non-transcriptional activation of IRF3 by RIPA causes cell death 115004 3661 57506 7186 29110 7187 7189 581 PMC8066875__F8 NFKB pathway and NLRP3 inflammasome activation and role of some microRNAs 275 3479 3481 3654 15 3667 114548 7189 79792 2475 3553 PMC8067156__F2 Pathophysiology of Ulcerative Colitis 2625 3662 920 50943 2921 2919 3627 3576 PMC8067275__F1 MicroRNAs that regulate the core components of Hippo signaling pathway 4771 4485 723778 26524 9113 374 9686 PMC8070103__F1 RAF-MEK-ERK pathway is activated by H/K and NRAS upon extracellular stimuli 4893 673 369 5894 PMC8071327__F5 SphK1 and S1P signaling in colorectal carcinogenesis and progression 6774 8877 6497 7124 PMC8072347__F1 OSCAR Signaling in Osteoclastogenesis and Bone Disease 6714 7189 4772 29760 695 7006 100124696 PMC8073961__F2 Role of adiponectin in VSMC 3667 387 9927 PMC8073974__F7 Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling 4018 57121 7046 619537 PMC8074291__F7 Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells 2475 3603 3569 596 1956 7124 207 6774 PMC8076851__F4 Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice 5443 3953 3952 83756 80834 5330 948 29850 2865 2864 338557 2867 PMC8086041__F1 Pulmonary Macrophage Cell Death in Lung Health and Disease 842 841 836 834 79792 1687 81030 197259 3552 90865 PMC8088128__F3 Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective 22808 8036 23513 55914 57521 5290 7415 5705 10075 55294 PMC8089370__F1 Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment 8140 6520 468 6510 10413 7275 8531 10652 3993 PMC8093976__F2 Insights into the regulatory role of Plexin D1 signalling in cardiovascular development and diseases 23129 10512 8829 9723 PMC8096869__F2 Proposed stem cell concept for the development of leiomyomas 960 947 1499 9968 PMC8096981__F2 Inflammation-Mediated Angiogenesis in Ischemic Stroke 1956 5163 5728 572 2056 PMC8101994__F8 Proposed role of PD-L1 on contraction of activated effector T cells 920 324 940 941 942 2475 PMC8102118__F6 Cell Division Autoantigen 1 (CDA1) in Renal Fibrosis of Diabetic Nephropathy 4092 4089 4087 4088 PMC8102120__F1 Pyroptosis: A New Frontier in Kidney Diseases 9447 3603 114548 79792 PMC8102492__F7 4-1BB-p38 MAPK-Dkk1 signaling pathway in BMSCs of aged mice 22943 324 4040 4041 PMC8103321__F1 APC Promoter Methylation in Gastrointestinal Cancer 1499 2932 324 2146 1045 10153 7528 7391 7392 23237 PMC8104964__F1 TLR4 signaling pathways 929 3929 7099 29110 114609 4615 7189 7187 7124 353376 148022 3661 3665 3456 3627 PMC8105194__F1 Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors 747 2166 6295 PMC8106074__F1 Hepcidin pathway and the regulation of body iron homeostasis 164656 148738 650 654 7036 3077 3716 6774 57817 PMC8106283__F1 Preventive Role of Cannabinoids Derivate against Methylphenidate-Induced Oxidative Stress and Inflammation: The Hypothetical Function of Keap1/Nrf2/ARE Signaling and Proposal of a Treatment Strategy for Neurodegeneration 9817 3553 847 581 572 PMC8107375__F5 Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells 59272 7098 7113 3627 PMC8107720__F5 Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer 468 9965 2264 2932 6774 PMC8112288__F1 Insights on the mechanisms of action of ozone in the medical therapy against COVID-19 4094 9817 405 847 PMC8113373__F4 CircRNAs: role in human diseases and potential use as biomarkers 9113 26524 4288 699 6790 PMC8114202__F5 Thyrotrophin and thyroxine support immune homeostasis in humans 7187 958 7189 3665 51311 51284 54106 3654 PMC8117419__F2 Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy 2643 2879 7455 PMC8118165__F1 Pembrolizumab in unresectable or metastatic MSI-high colorectal cancer: safety and efficacy 941 942 940 3902 1499 PMC8119568__F1 microRNAs: New-Age Panacea in Cancer Therapeutics 29102 54487 5901 PMC8120178__F2 Phytochemicals in Chemoprevention: A Cost-Effective Complementary Approach 2932 4193 572 2475 PMC8120466__F6 MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer 1950 6395 1956 4584 PMC8120650__F4 Autophagy-related signaling pathways are involved in cancer (Review) 2475 8408 7249 PMC8122391__F3 Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma 6850 6774 4193 572 PMC8123284__F2 Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis 7018 1356 2242 PMC8124719__F9 Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells 6714 1956 6774 4193 581 8011 PMC8125482__F3 Multifaceted Roles of USP15 in Signal Transduction 2475 4193 9958 PMC8127782__F4 Canine Parvovirus and Its Non-Structural Gene 1 as Oncolytic Agents: Mechanism of Action and Induction of Anti-Tumor Immune Response 596 317 581 PMC8129516__F1 Glycogen Synthase Kinase 3B Modulates the Inflammatory Response Activated by Bacteria, Viruses, and Parasites 7097 54106 7100 7099 4615 8321 7855 2932 7473 1855 7124 1499 6772 6774 PMC8131681__F2 Smad Dependent TGFB and BMP Signaling Pathway in Bone Remodeling and Therapies 7189 7187 4087 10454 4772 4088 PMC8135095__F1 Microglia: A Double-Edged Sword in Intracerebral Hemorrhage From Basic Mechanisms to Clinical Research 6772 7097 7099 3458 6778 PMC8137895__F1 Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases 5901 27161 29102 54487 PMC8138133__F6 Cox4i2 Triggers an Increase in Reactive Oxygen Species, Leading to Ferroptosis and Apoptosis in HHV7 Infected Schwann Cells 84701 2879 23657 6520 PMC8138161__F2 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway 355 8772 637 790 2021 PMC8140811__F7 Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers 5228 284 7158 285 31 2335 8829 4627 7852 596 6387 1956 4851 7422 6850 1111 3791 10397 PMC8141729__F7 Beta-Asarone Ameliorates Beta-Amyloid–Induced Neurotoxicity in PC12 Cells by Activating P13K/Akt/Nrf2 Signaling Pathway 581 847 4094 9817 PMC8145841__F2 Enigmatic Evolutionary History of Porphobilinogen Deaminase in Eukaryotic Phototrophs 210 7390 7389 1371 5498 2235 PMC8146591__F2 Glutathione S-Transferases in Cancer 2950 7186 2475 PMC8147131__F7 Metformin Dysregulates the Unfolded Protein Response and the WNT/Beta-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism 468 1499 22926 PMC8147802__F2 Pluripotency and Growth Factors in Early Embryonic Development of Mammals: A Comparative Approach 3479 3481 596 7852 79923 581 578 PMC8147868__F2 Epigenetics of Hepatic Insulin Resistance 8841 2887 3485 3479 5629 3172 3643 3667 8660 5163 780897 2308 7391 221037 5253 23411 7019 PMC8152700__F5 Cardiac fibrosis 2932 324 4040 4041 1281 10631 1277 847 PMC8156356__F2 Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function 2475 6774 5970 8772 581 PMC8157467__F7 3-Methyladenine but not antioxidants to overcome BACH2-mediated bortezomib resistance in mantle cell lymphoma 60468 3162 571 PMC8158527__F1 Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering 4087 4088 4089 650 4090 4086 1499 860 121340 PMC8164580__F1 Neuronal dysfunction in HIV-associated neurocognitive disorders 6714 7852 6387 5879 PMC8164819__F6 Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance 4090 4086 4089 4838 7046 4087 4088 10818 2353 PMC8168945__F1 Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling 1595 51478 6309 10682 1717 1718 PMC8169867__F8 EGFR-HIF1A signaling pathway in Th9 cells 3566 4843 85480 1956 3091 PMC8170089__F2 EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress 4092 4088 5728 999 79602 5598 64067 PMC8170118__F5 Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data 27040 11186 5894 100137049 2002 2113 PMC8170620__F4 Roles of Host Noncoding RNAs in Mycobacterium tuberculosis Infection 5728 4853 100302168 2146 PMC8172903__F3 STING1 network regulates autophagy and cell death 3661 836 29110 115004 598 578 581 54205 317 8772 841 842 840 4790 11035 7124 197259 PMC8173334__F1 Diabetes and Cardiovascular Complications: The Epidemics Continue 5763 3662 10379 3665 367 PMC8178581__F2 Notch signaling pathway involvement in innate lymphoid cell biology 102 1840 3458 8320 10219 55540 6097 7091 149233 3280 6932 2625 PMC8180257__F7 MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus 2302 7474 4211 4920 4919 PMC8187249__F2 Protected complex of biofactors and antioxidants improved growth performance and modulated the immunometabolic phenotype of broiler chickens undergoing early life stress 23411 6774 149233 114609 7186 51284 PMC8187928__F1 Cellular cholesterol metabolism 3949 3156 4598 19 9619 2222 6713 9023 6010 4864 PMC8191541__F2 Viperin Reveals Its True Function 57506 3659 3661 3665 3654 7189 6773 6772 10379 129607 PMC8194146__F4 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer 195828 8239 6935 4485 9113 26524 1382 PMC8194326__F1 T follicular helper cells: linking cancer immunotherapy and immune-related adverse events 920 941 942 940 958 PMC8194669__F2 Karyopherin abnormalities in neurodegenerative proteinopathies 5901 1104 10763 3837 PMC8195365__F8 Tentative mechanistic model for MERS-CoV-induced protective innate immune responses in alpaca respiratory tracts 3586 6347 6348 3569 114548 3553 3627 9636 4599 4938 3663 3665 6772 3661 3600 PMC8196684__F1 Methylation Patterns of DKK1, DKK3 and GSK3B Are Accompanied with Different Expression Levels in Human Astrocytoma 2932 1499 324 4040 4041 PMC8197977__F1 Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer 130013 23475 93100 10135 203447 4837 PMC8197977__F3 Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer 952 10135 316 4837 PMC8198078__F2 Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of Beta-Amyloid Protein and Phosphorylated Tau 6786 6262 7220 84876 6263 PMC8198123__F2 Therapeutics Targeting the Core Apoptotic Machinery 355 8772 637 331 581 PMC8199207__F2 Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers 920 115004 3661 PMC8199938__F5 Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders 2166 9290 7442 PMC8201404__F2 GIMAP Family Proteins: An Incomplete Puzzle 3716 3718 6009 7249 7248 3932 7535 55340 2932 27040 2885 2475 PMC8201405__F4 Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms 115004 22954 3661 29110 PMC8201567__F8 Promotion effects of DEHP on hepatocellular carcinoma models: up-regulation of PD-L1 by activating the JAK2/STAT3 pathway 4280 3717 6774 PMC8201612__F4 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand 2475 6009 64223 7249 7248 152926 718 727 PMC8201651__F1 Wnt/Beta-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities 4040 4041 1499 84133 54894 252839 55366 8549 PMC8203325__F3 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges 5045 100188776 4318 4313 595 PMC8204249__F1 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms 811 4352 3717 6774 7173 867 10019 PMC8204249__F5 Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms 3717 7124 9242 6351 6348 3553 7173 PMC8204302__F7 Host determinants of disease severity in acute cystitis; mechanism of IL-1B and SP hyperactivation 3553 114609 4615 7099 114548 834 729 4316 4280 PMC8204445__F1 Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease 8942 130013 8564 23498 23475 PMC8207419__F5 Cytoplasmic‐translocated Ku70 senses intracellular DNA and mediates interferon‐lambda1 induction 29110 3659 3665 3661 PMC8209516__F3 Markers and Reporters to Reveal the Hierarchy in Heterogeneous Cancer Stem Cells 6657 4851 1499 10013 PMC8210610__F8 Major vault protein (MVP) negatively regulates osteoclastogenesis via calcineurin-NFATc1 pathway inhibition 4286 4772 9961 1513 100187907 4318 PMC8211510__F1 Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway 4280 1506 117159 PMC8211512__F2 Mitochondrial Quality Control in Cardiac Ischemia/Reperfusion Injury 7019 9927 664 PMC8215363__F2 Reversing Post-Infectious Epigenetic-Mediated Immune Suppression 8841 4703 3661 7189 4615 3627 23411 5971 3146 1786 9021 3553 7124 8651 PMC8217106__F1 Direct Targeting of Beta-Catenin in the Wnt Signaling Pathway: Current Progress and Perspectives 324 4041 607 847 4040 2932 PMC8219471__F1 STING and liver disease 115004 3661 633 PMC8220219__F3 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer 1869 101926978 3178 641364 100500834 100420631 100316868 347689 100130776 11091 2521 100187761 2146 51700 26153 8848 51129 PMC8221395__F4 Use of Iron Oxide Nanoparticles to Reprogram Macrophage Responses and the Immunological Tumor Microenvironment 8544 4094 2512 PMC8223819__F1 Dynamics of host immune responses to SARS-CoV-2 3559 3082 6348 51311 7098 51284 4843 716 PMC8224255__F2 Efficacy of phytochemicals as immunomodulators in managing COVID-19: a comprehensive view 3569 59272 3558 PMC8224327__F2 Anti-Angiogenic Property of Free Human Oligosaccharides 4851 1956 7422 1950 54567 7424 PMC8224678__F1 Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis 7097 54106 51284 7098 10010 114609 8195 7189 10333 4671 114548 PMC8226128__F3 Inflammasomes and Fibrosis 9817 114548 3146 10628 PMC8226666__F2 Hippo Pathway: A Master Regulatory Network Important in Cancer 2475 57608 4485 PMC8226978__F1 Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management 5728 572 596 367 6774 2638 PMC8228391__F1 Bilirubin: A Promising Therapy for Parkinson’s Disease 920 23400 120892 65018 950 6609 6622 7124 PMC8229583__F7 17B Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway 4025 581 2670 6855 PMC8229991__F2 Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from Fibrodysplasia Ossificans Progressiva Patients 3624 4093 130399 4086 90 4089 93 4092 4087 4088 659 92 10468 3625 10272 4090 PMC8231946__F2a Proliferation, dissemination and proteasome inhibitor resistance 7852 952 100187907 374 PMC8232086__F2 Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review 5728 4193 6608 51684 2131 2475 2000 PMC8234594__F1 Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review 7124 2932 1499 595 999 3169 7186 7185 7187 PMC8235326__F1 Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma 342538 6786 84876 90550 91689 PMC8238076__F5 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation 10020 54210 467 8650 4209 7157 55252 374 9212 81704 1029 6909 PMC8238141__F7 Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells 9361 5925 253260 5927 PMC8238154__F9 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells 3594 6363 2358 8398 6367 4283 3108 3118 3111 3113 3127 3122 3117 3109 3115 3112 3120 920 3123 PMC8238245__F1 Action of PLK inhibition 2475 10733 10769 1263 PMC8243062__F3 NRF2 signalling pathway and antioxidant therapeutic approaches 2932 9817 571 4094 29110 672 PMC8249877__F3 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development 5629 2303 4047 84876 9780 7424 PMC8253380__F1 Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies 2735 8549 3280 6469 429 PMC8259493__F2 Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies 5310 5311 2475 PMC8259730__F1 Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction [Corrigendum] 64806 90865 85480 PMC8259786__F3 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease 4851 1839 54361 650 1499 PMC8261820__F3 Signal pathways and treatment of cytokine storm in COVID-19 51284 59272 4615 7098 51311 57506 3661 3665 7297 3716 6772 6773 10379 PMC8262388__F6 Interplay Between Mitochondrial Reactive Oxygen Species, Endoplasmic Reticulum Stress, and Nrf2 Signaling in Cardiometabolic Health 468 9518 26291 PMC8264328__F1 One carbon metabolism in human lung cancer 7298 4522 6472 10797 PMC8265131__F8 Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways 4280 9817 2181 2182 5742 5743 5740 301 307 302 308 309 306 5608 4048 4015 8398 5322 100137049 240 4056 2678 1800 2180 PMC8266377__F2 Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy 3661 3665 57506 3455 7297 6773 10379 6772 3454 3716 PMC8267696__F1 Metabolic Reprogramming: A Friend or Foe to Cancer Therapy? 8772 331 355 637 4170 581 317 PMC8267717__F2 Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis 3929 7099 4615 3654 51135 7189 929 3661 PMC8267878__F5 Current Understanding of IL-37 in Human Health and Disease 860 5879 6348 6364 7474 PMC8268320__F2 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? 619501 8205 100507436 920 2475 6352 6347 6354 58191 PMC8268933__F3 Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis 581 1019 1021 595 7852 5054 4320 5327 PMC8269088__F2 Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets 55294 54567 28514 10683 6363 PMC8271933__F2 Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products 1443 717 847 PMC8273916__F8 Kaempferol Alleviates Steatosis and Inflammation During Early Non-Alcoholic Steatohepatitis Associated With Liver X Receptor Alpha-Lysophosphatidylcholine Acyltransferase 3 Signaling Pathway 637 27201 468 22926 PMC8274179__F1 Cell death as part of innate immunity: Cause or consequence? 3606 11035 4353 581 100187907 PMC8275986__F1 Calcium, an Emerging Intracellular Messenger for the Hippo Pathway Regulation 64423 154810 4485 23327 9113 26524 PMC8276021__F4 T Cell Protein Tyrosine Phosphatase in Glucose Metabolism 3716 3717 2690 4852 181 5443 6772 PMC8276693__F2 Tumor Microenvironment Factors That Promote Resistance to Immune Checkpoint Blockade Therapy 324 940 3458 3717 3716 6772 3659 PMC8277916__F5 Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies 7124 9817 4094 847 4209 PMC8281110__F3 M6A in osteoporosis, arthritis and osteosarcoma (Review) 7189 56339 79068 4615 10220 1050 9242 23269 PMC8281110__F6 M6A in osteoporosis, arthritis and osteosarcoma (Review) 56339 29028 51176 4733 1499 54890 5820 51441 PMC8282197__F6 Identifying Biomarkers from Transcriptomic Signatures in Renal Allograft Biopsies Using Deceased and Living Donors 2949 2939 9332 2948 2947 85451 929 6283 10333 7099 23643 151295 6376 1462 595 6366 220 1014 23213 PMC8283807__F10 MitoROS-PKCG-mediated endoplasmic reticulum stress (ERS)-dependent induction of the TXNIP/NLRP3 signaling axis 7097 468 114548 10628 PMC8286283__F3 Cellular roles of ER-phagy and the contributions of metazoan ER-phagy receptors 51368 9236 7095 25923 PMC8286839__F7 Feedback inhibition arising from NFKB activation operates at all levels in the pathway 59307 84166 105416157 10370 PMC8286839__F8a Figure 8.NFKB dependent inhibitory feedback at the receptor level 7099 929 3550 PMC8287682__F9 CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity 112616 5447 2475 PMC8287856__F1 Dissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution 4088 4087 2475 1499 6469 4312 7070 4316 PMC8288800__F5 Long noncoding RNAs in metastasis site-specific tropism 7503 3717 221078 6774 6347 4485 3383 PMC8291223__F8 A High-Grain Diet With a Buffering Agent on Milk Protein Synthesis in Lactating Goats 7462 29904 6009 2475 1938 1975 1977 1447 PMC8291481__F4 Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain 5091 907 1103 7054 43 55349 PMC8292425__F1 Sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle 84649 6319 4247 4099 8694 PMC8292787__F1 Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy 85480 90865 8213 613 5091 3568 920 7908 PMC8292951__F1 RNA Methylation in Systemic Lupus Erythematosus 9021 56339 1154 3574 57721 8835 51676 3558 PMC8293794__F1 New developments implicating IL-21 in autoimmune disease 920 3458 50615 6772 6774 PMC8293794__F2 New developments implicating IL-21 in autoimmune disease 920 3718 3716 6772 PMC8294190__F2 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? 1950 1956 7045 3066 PMC8298031__F2 In vitro Assays and Imaging Methods for Drug Discovery for Cardiac Fibrosis 7040 387 1490 PMC8299562__F2 Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies 9021 2475 3953 6774 1977 4852 10645 9965 PMC8301965__F9 Hair Growth Stimulation Effect of Centipeda minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways 4040 4041 1499 324 3479 PMC8301972__F2 Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal Transition 4072 6591 6615 7291 6935 PMC8302486__F3 Interferon B, an enhancer of the innate immune response against SARS-CoV-2 infection 7297 3716 6773 10379 10410 6041 8638 3669 100187761 PMC8306787__F3 Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance 200186 55384 468 1959 440823 4017 355 3606 PMC8306961__F6 Arginine Signaling and Cancer Metabolism 673 2621 558 2932 4609 445 54210 6850 695 6347 6774 2475 729230 PMC8307196__F7 Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells 1950 3717 1956 6777 PMC8307462__F1 NMDARs, Coincidence Detectors of Astrocytic and Neuronal Activities 26227 29968 5723 PMC8308226__F1 MiR-155 in Nutrition: Modulating Cancer-Associated Inflammation 3569 6774 3716 7428 8651 4089 387 PMC8308767__F4 Phytomedicines Targeting Cancer Stem Cells: Therapeutic Opportunities and Prospects for Pharmaceutical Development 5925 6469 6608 1499 2735 2736 PMC8310235__F3 Human Papillomaviruses Target the DNA Damage Repair and Innate Immune Response Pathways to Allow for Persistent Infection 83939 57506 3661 115004 29110 3428 10379 6772 6773 7297 PMC8311004__F1 Necroptosis: A Novel Pathway in Neuroinflammation 8737 8772 7124 8717 1540 7186 11035 197259 PMC8313992__F10 Acute TBK1/IKKE Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury 338773 968 29110 1435 3458 90865 64805 29949 PMC8315846__F6 MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture 5740 4615 51135 3654 7189 7529 PMC8316210__F8 Latent Membrane Protein 1 Promotes Tumorigenesis Through Upregulation of PGC1B Signaling Pathway 2551 4899 80201 PMC8316605__F1 Cryo-EM: A new dawn in thyroid biology 7253 7038 8205 PMC8318642__F3 Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome 146225 54918 3553 123920 112616 29760 613 113540 PMC8320333__F8 A New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma 1021 1019 2475 PMC8323235__F9 ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways 1956 2932 3667 2308 PMC8324245__F7 Ovine CD14- an Immune Response Gene Has a Role Against Gastrointestinal Nematode Haemonchus contortus—A Novel Report 3929 7097 10333 929 7100 54472 114609 4615 1513 54106 7098 8772 7189 7187 23118 3665 3661 7124 958 PMC8324678__F1 Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD 4018 5091 123 PMC8324686__F2 Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD) 255738 9784 3949 PMC8329661__F2 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? 581 7157 1029 317 1021 1019 PMC8332866__F9 Epimedokoreanin C, a prenylated flavonoid isolated from Epimedium koreanum, induces non-apoptotic cell death with the characteristics of methuosis in lung cancer cells 8411 382 200576 PMC8335813__F6 HHLA2 deficiency inhibits non‐small cell lung cancer progression and THP‐1 macrophage M2 polarization 11148 1956 4318 4313 1000 9332 1017 1021 1019 PMC8338747__F1 ExTreg generation 2475 10273 5728 50943 861 865 8320 3717 6774 1788 90865 2625 6761 3091 PMC8338882__F2 HPV immune modulation of the tumor microenvironment 50943 920 940 941 942 3133 PMC8346058__F2 Targeting Inflammation after Myocardial Infarction: A Therapeutic Opportunity for Extracellular Vesicles? 4615 3654 7189 729230 3479 114548 1901 712 6868 10461 PMC8346982__F2 Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment 8692 960 3373 3038 3037 594842 7046 1499 PMC8348042__F2 Transient Receptor Potential Channels in the Epithelial-to-Mesenchymal Transition 54822 54795 7220 7222 59341 7226 6659 6591 1499 79054 51393 7225 7224 1950 3082 PMC8348456__F1 Inflammatory Response in COVID-19 Patients Resulting from the Interaction of the Inflammasome and SARS-CoV-2 59272 7113 114548 3553 79792 PMC8348676__F1 Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis 2002 23211 25923 2621 2475 8678 4615 7099 PMC8349734__F5 Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study 207 3326 596 PMC8350018__AF1 Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway 1499 367 3479 7291 1026 7157 6741 PMC8350388__F1 Role of Traditional Chinese Medicines by Wnt/Beta-Catenin Pathway Compared With Targeted Small Molecules in Colorectal Cancer Therapy 324 2932 1499 8945 3845 54894 1950 1956 8549 PMC8350499__F1 Acetylation in doxorubicin-induced cardiotoxicity 10013 114548 10642 23411 257000 2475 581 23410 4976 6773 6774 6772 3717 3480 3479 PMC8350546__F7 NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells 1618 1617 346673 339345 6009 10541 5757 595 PMC8351444__F7 MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies 6850 4609 6714 3717 613 4149 2000 PMC8351892__F1 Tracing the roots of CLPD-NK by TET2 and STAT3 54790 6774 1788 PMC8353059__F2 Emerging Role of PD-1 in the Central Nervous System and Brain Diseases 10538 7535 941 2475 940 3716 3717 6772 3718 6778 PMC8353273__F2 Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases 59343 267 3638 57337 9706 8408 8975 27005 51428 5167 79594 23650 115004 284076 9654 91445 9830 10475 10146 85364 10084 81844 22954 90933 3428 6048 79102 197358 56681 9632 PMC8355620__F4 Eccrine Sweat Gland and Its Regeneration: Current Status and Future Directions 4040 4041 1499 2932 324 128178 10913 6469 6608 374654 4086 51684 4089 4609 2885 PMC8357478__F9 Tianma Formula Alleviates Dementia via ACER2-Mediated Sphingolipid Signaling Pathway Involving AB 7018 983 340485 140 81624 5166 PMC8364356__F1 Imbalanced Coagulation in the Airway of Type-2 High Asthma with Comorbid Obesity 325 5340 2224 PMC8374228__F3 Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge 355 8772 613 60468 940 50943 941 6777 324 6774 942 987 PMC8375270__F1 When Viruses Cross Developmental Pathways 6608 51684 6469 3549 50846 2735 PMC8377336__F3 On the nutritional and therapeutic effects of ketone body d-Beta-hydroxybutyrate 5132 100187761 2865 114548 PMC8377872__F5 Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus 105373557 5580 6814 8473 22841 PMC8380402__F10 NCAPG promotes the progression of lung adenocarcinoma via the TGFB signaling pathway 64151 4087 4088 4089 7018 999 1000 PMC8383068__F1 Proteomics Mapping of the ISGylation Landscape in Innate Immunity 3459 3454 10379 3460 9636 3716 3455 11274 7318 9246 51191 6714 PMC8386127__F11 TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage 7099 4615 102 54209 1611 4023 558 3586 PMC8388553__F9 Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3B signaling pathway 409 2932 596 581 PMC8389593__F8 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway 9968 84133 2932 4040 PMC8389681__F6 Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context 1514 5566 26229 10868 79654 8916 84867 10273 84447 11060 9867 153830 267 83737 1717 1540 23043 3611 1595 6713 PMC8392360__F2 PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches 695 673 1493 PMC8392407__F2 Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options 9113 26524 3479 4485 3480 7018 3481 PMC8392837__F1 46,XX DSD: Developmental, Clinical and Genetic Aspects 6770 1583 3284 1589 5447 1585 1586 1584 1588 PMC8393536__F1 Myostatin/Activin-A Signaling in the Vessel Wall and Vascular Calcification 2660 238 4088 4087 6997 7124 PMC8393760__F3 Molecular Aspect of Nephrolithiasis Development 353 4860 7498 PMC8395432__F2 SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection 142 6101 7113 PMC8398928__F1 Current Therapies in Clinical Trials of Parkinson’s Disease: A 2021 Update 65018 120892 7345 PMC8401694__F2 Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies 5168 860 2863 650 PMC8402745__F3 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges 7099 3146 4615 10747 114548 834 PMC8403095__F7 Higher-order assemblies in immune signaling: supramolecular complexes and phase separation 920 2885 3932 27040 7535 PMC8403340__F3 Glutamate-mediated, calcium-related signaling in glioma progression 57622 146395 64072 54798 9229 2890 2902 83698 9381 1742 9456 2913 10398 10627 4638 22839 801 781 2915 782 783 2897 8913 779 2752 775 2898 776 56145 2280 444 2475 10345 2899 2904 56147 6262 6263 90 2281 5534 2892 7046 57497 93408 4627 4633 774 786 PMC8406585__F10 TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage 114548 79792 3553 PMC8406742__F2 Neutrophil Extracellular Traps in Cancer 4353 3146 3553 1956 634 3845 PMC8410881__F1 Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression 6247 3643 3099 3098 2821 5213 5214 226 5315 PMC8411705__F2 Neutrophils in Glioma and Brain Metastases 11201 3458 3576 6347 7226 4318 3146 942 54106 920 7422 PMC8415165__F11 Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling Pathway 6774 3553 3717 9021 PMC8416724__F4 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy 140885 961 325 PMC8416736__F3 Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations 6722 3553 6347 9314 355 8772 51548 PMC8418145__F2 Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases 7942 65018 958 PMC8421605__F4 Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis 39 4023 51144 201562 79071 3032 3033 10999 3952 6319 PMC8423581__F2 Exosome: Function and Application in Inflammatory Bone Diseases 4615 51135 7189 100124700 3550 5970 5971 PMC8423581__F3 Exosome: Function and Application in Inflammatory Bone Diseases 7188 7189 7186 23118 7124 4286 6714 5728 PMC8423581__F4 Exosome: Function and Application in Inflammatory Bone Diseases 100124700 4038 4040 4041 50964 324 860 468 PMC8424196__F3 Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease 1840 50943 113878 2167 23220 142 151636 8027 29110 147945 84640 3661 PMC8424549__F4 Regulation and metabolic functions of mTORC1 and mTORC2 10797 471 3615 2539 22934 5634 4609 7086 4975 790 PMC8424797__F2 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy 85028 104472715 728190 407975 285943 693222 10000 80312 581 29128 6935 5970 PMC8424797__F3 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy 7015 6935 54918 146223 920 55833 103611090 PMC8424978__F7 Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway 8205 6774 6403 6401 PMC8425587__F6 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) 1950 4077 7189 1956 3091 7428 367 PMC8426249__F1 Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse 3456 3439 3454 3455 6772 6773 3665 5610 64135 9636 2635 3434 3437 57506 7019 29110 8192 115004 3553 3569 3606 PMC8429127__F1 Sulforaphane-Nrf2-GSTM1 pathway in the prevention of kidney disease progression: Gene - diet interaction 2944 9817 1645 1728 PMC8429580__F1 NLRP3 inflammasome activation and cell death 4615 7099 114548 79792 8772 PMC8429580__F2 NLRP3 inflammasome activation and cell death 581 114548 637 355 8772 79792 1687 7124 7186 7188 8717 7099 4615 PMC8430060__F5 Gene expression patterns of neuronal cells reveal the pathogenesis of autism 1956 7012 3569 3135 7422 4311 PMC8430084__F2 Neutrophil extracellular traps (NETs): the role of inflammation and coagulation in COVID-19 7018 5340 100187907 100038247 2224 7450 11093 7035 PMC8430223__F4 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases 2475 10631 6778 1499 4322 4314 9507 4312 4843 PMC8430485__F2 Immune-Checkpoint Inhibitors for Metastatic Colorectal Cancer: A Systematic Review of Clinical Outcomes 1950 1956 2475 7422 920 941 PMC8430581__F2 Large Granular Lymphocytic Leukemia: From Immunopathogenesis to Treatment of Refractory Disease 149233 6774 3717 9475 9021 3601 940 2475 1043 942 324 PMC8430758__F4 Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease 7099 3929 4615 929 7124 PMC8430922__F3 Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases 4803 387 4088 260431 PMC8431333__F5 Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression 51684 2735 387 9828 6722 PMC8431517__F10 Network Pharmacology Study on Morus alba L. Leaves: Pivotal Functions of Bioactives on RAS Signaling Pathway and Its Associated Target Proteins against Gout 207 5578 5320 PMC8431684__F2 Therapeutic Potential of Targeting the SUMO Pathway in Cancer 5371 5914 7341 10401 2078 8554 367 29843 9063 PMC8431827__F2 Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan Beta-Coronaviruses 3576 6347 4780 3162 PMC8434356__F11 New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway 581 596 2475 7157 PMC8437140__F2 H19 in liver injury and fibrosis 283120 6347 596 5725 6935 4072 PMC8440972__F3 Houttuynia cordata Thunb: An Ethnopharmacological Review 9817 581 619501 PMC8441359__F2 Chronic low‐grade inflammation in heart failure with preserved ejection fraction 7124 114548 3553 3554 3466 79792 PMC8446424__F2 TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy 54209 6850 1499 2475 PMC8446437__F2 Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation 3458 3620 196 PMC8446806__F1 Complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain 728 27202 715 716 717 721 729 7448 5648 730 1378 718 735 1380 PMC8448420__F2 Autophagy and Mitochondrial Homeostasis During Infection: A Double-Edged Sword 51295 114609 7189 8678 2475 7187 3661 PMC8449753__F1 How FGF23 shapes multiple organs in chronic kidney disease 8074 5745 7421 5741 84876 3091 2056 2591 PMC8450384__F4 Glucose Metabolism and Glucose Transporters in Breast Cancer 3099 2539 3939 26227 7086 PMC8452443__F3 Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis 2308 10365 29851 604 324 643 1236 PMC8460903__F5 Mechanotransduction Regulates Reprogramming Enhancement in Adherent 3D Keratocyte Cultures 2331 6010 4087 4088 4090 4086 PMC8463267__AF1 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NFKB and RAS/RAF/MEK/ERK signaling pathway 960 407040 1000 999 PMC8463267__F10 Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NFKB and RAS/RAF/MEK/ERK signaling pathway 960 407040 1000 999 PMC8463536__F3 P53 family members, such as p53, p63, and p73, some transcription factors, such as SP1 and CREB, and noncoding miRNAs, such as miR-144, miR-885-5p, and miR-101 regulate the transcription of TIGAR 7468 57103 4609 6667 3091 PMC8463915__F2 Diverse roles of TMEM16A Ca2+-activated Cl− channels in inflammation 3566 6778 6774 1950 1956 7099 PMC8465200__F1 Association between Polymorphisms in Vitamin D Pathway-Related Genes, Vitamin D Status, Muscle Mass and Function: A Systematic Review 1717 846 5741 1593 1576 120227 1628 1594 6256 6257 7421 8029 4036 1591 PMC8465210__F10 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity 1499 2932 324 999 595 10397 PMC8465517__F2 Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease 7030 7018 10488 378 468 83939 PMC8465904__F3 Crosstalk of the Wnt/Beta-Catenin Signaling Pathway in the Induction of Apoptosis on Cancer Cells 355 637 581 319 PMC8466405__F4 Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome 114609 4615 3569 PMC8466445__F1 Anti-Viral Pattern Recognition Receptors as Therapeutic Targets 7098 7189 7124 3661 51311 51284 695 3656 3654 4151 54106 29110 7187 57506 3665 115004 9365 PMC8466454__F7 Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling 9817 4094 8549 847 PMC8466551__F1 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis 6608 23432 51684 2932 PMC8466551__F5 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis 6667 6608 6469 5727 PMC8467578__F1 Looking at Alzheimer’s Disease Pathogenesis from the Nuclear Side 3925 2932 102 23411 348 351 26136 PMC8468056__F6 GPR30 Activation by 17Beta-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor A Protein Expression by Inducing Its Release from a Complex Formed with KEAP1 2099 6714 9817 1956 2475 PMC8469138__F4a Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis 3426 731 722 1361 7273 4609 940 917 914 8557 3560 920 5360 5199 PMC8469138__F6 Molecular Biology Networks and Key Gene Regulators for Inflammatory Biomarkers Shared by Breast Cancer Development: Multi-Omics Systems Analysis 3717 8027 6775 3932 335 3931 5360 348 6774 51083 4851 338 3716 7297 4855 2781 3710 2770 8139 5578 3708 PMC8469440__F3 Kynurenine Pathway—New Linkage between Innate and Adaptive Immunity in Autoimmune Endocrinopathies 324 2475 196 920 7054 PMC8475840__F4 Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection 652968 7249 7248 23411 PMC8476782__F2 Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target 4320 4851 2534 6667 6304 PMC8478550__F2 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases 4087 4088 4089 114548 PMC8478550__F3 Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases 4088 4087 4089 50507 114548 PMC8480040__F2 Long non-coding RNA H19 in the development of osteoporosis 283120 5747 9242 2303 3714 182 1499 860 27121 4088 100033819 PMC8481579__F5 Paeoniae Radix Alba in the Treatment of Non-alcoholic Fatty Liver Disease Based on Sequential Metabolites Identification Approach, Network Pharmacology, and Binding Affinity Measurement 3643 3630 3667 7186 3569 3952 3953 PMC8484301__F4 Novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway 7099 4615 4118 29110 7100 115004 7507 3661 54106 PMC8485019__F1 Bile reflux and hypopharyngeal cancer 1956 207 7157 598 3586 3569 7474 3553 6774 PMC8487962__F1 Complement activation and its effects in periodontitis 5648 10747 718 727 PMC8491217__F2 Lipid metabolism in cancer progression and therapeutic strategies 4485 5225 9113 26524 47 2194 PMC84916__F8 The mechanism of regulation of PLCG2 tyrosine phosphorylation and activation by LAT 27040 5336 2534 4067 2885 6850 PMC8492288__F2 Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview 196 7124 3397 3398 PMC8493254__F6 Proteome Modulation in Peripheral Blood Mononuclear Cells of Peste des Petits Ruminants Vaccinated Goats and Sheep 10379 91543 3454 2620 6773 6772 122809 30837 3660 81030 3665 9636 3434 3661 84807 56829 7706 PMC8495264__F7 Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing 6934 79570 79923 3164 8928 53840 596 2908 56147 127124 1855 253260 10218 4774 51473 1499 2099 2769 10675 9355 PMC8495394__F3 P38G in Cancer: From review to outlook 2152 389 2625 2066 23512 1499 7018 5209 PMC8495584__F3 Research progress on evodiamine, a bioactive alkaloid of Evodiae fructus: Focus on its anti-cancer activity and bioavailability (Review) 581 2475 6774 PMC8495593__F2 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers 6009 5728 7249 7248 PMC8502110__F5 MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in Gamma-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease 586 260431 2475 5728 387 23365 PMC8503602__F3 Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms 1499 4040 4041 2932 664 7942 PMC8507062__F3 Crucial role for the long non-coding RNA CASC11 in the pathogenesis of human cancers 100270680 2146 5728 1499 3190 9775 1869 PMC8508208__F4 Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma 8205 5008 7040 9636 4838 6469 2475 PMC8508793__F2 RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective 6905 9118 9111 2521 102723619 6311 100302155 PMC8509036__F1 B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy 7124 7186 8717 8772 637 581 572 PMC8509318__F2 Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NFKB Activation: A Review of the Molecular Mechanisms 6478 1844 1843 PMC8509647__F3 Pathogenesis of IgA Nephropathy: Current Understanding and Implications for Development of Disease-Specific Treatment 717 721 720 718 729 735 727 730 966 2271 1378 10877 81494 10878 3078 3080 PMC8511434__F6 Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction 7434 7432 1235 6774 2475 3553 5212 7421 PMC8515183__F2 Interactions Between Pathogenic Burkholderia and the Complement System: A Review of Potential Immune Evasion Mechanisms 720 721 717 1356 718 5340 727 729 7448 PMC8517779__F1 Biomarkers for gastrointestinal adverse events related to thiopurine therapy 7172 11252 3704 8833 55270 PMC8517930__F7 Novel insights into the regulation of LATS2 kinase in prehierarchical follicle development via the Hippo pathway in hen ovary 7003 7005 6788 6789 26524 6770 2099 2100 2492 PMC8523237__F1 Kidney Cell Pyroptosis in Chronic Kidney Disease and the Effects of Traditional Chinese Medicine 114548 22861 9447 1756 PMC8523922__F2 IL-36 in the Pathophysiological Processes of Autoimmune Diseases 3558 6965 3565 6778 4615 PMC8524782__F2 Molecular Mechanisms of Hepatoblastoma 1499 8312 324 4041 2932 2752 9687 3950 8549 3082 PMC8526712__F5 Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy 8772 8717 7186 3554 8567 4615 51135 3656 6885 11213 3654 3718 6774 6772 3459 3717 3460 PMC8528729__AF1 MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer 4760 10413 25833 429 PMC8529875__F5 Mini Review: Biomaterials in Repair and Regeneration of Nerve in a Volumetric Muscle Loss 4899 7528 7019 7388 717 718 PMC8530968__F2 Axon growth and innervation of peripheral targets 1960 7474 4919 4920 958 3082 4803 3612 5879 627 58476 PMC8531525__F1 Targeting Microglial Alpha-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease 7097 114548 7099 6622 100126297 23410 PMC8531546__F2 Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage 7124 8877 5879 4775 PMC8533426__F5 LRP-1 Matricellular Receptor Involvement in Triple Negative Breast Cancer Tumor Angiogenesis 2522 8139 5327 3075 10468 718 7040 7077 23452 1277 3484 5340 PMC8533566__F7 SOD3 Levels Is Detrimental to Retinal Homeostasis 5864 100170220 57084 6809 83871 53407 PMC8534183__F5 New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NFKB Signaling-Mediated Inflammatory Responses in Human Monocytes 55240 7099 7124 23456 2235 10058 PMC8535158__F4 NUAK Kinases: Brain–Ovary Axis 406987 100302213 9891 999 7018 3479 1936 3065 4313 4318 406935 4088 81788 4087 PMC8535862__F2 Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer 1613 8975 8408 596 9077 55626 7341 5289 29982 22863 2309 6774 7405 6714 7071 PMC8538586__F3 Forms and Methods for Interferon’s Encapsulation 57506 3661 6772 3588 6773 3454 3434 3455 4599 PMC8539587__F1 Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens 7100 4615 8195 7097 7189 114548 9447 3553 PMC8541918__F5 Phosphorylation regulates Hippo pathway LLPS 4485 26524 9113 7454 PMC8541931__F2 Molecular pathways underlying homotypic circulating tumor cell (CTC) cluster formation 1021 3091 5062 3383 1956 960 PMC8542908__F3 Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An in silico Approach Using Bioinformatic Analysis 1956 7157 898 5925 5595 4609 7168 PMC8546260__F1 TNFA/TNFR2 Pathway: Targeting a Brake to Release the Anti-tumor Immune Response 8717 8772 11035 8737 8767 7186 717 PMC8547927__F3 PARP Inhibition in Prostate Cancer With Homologous Recombination Repair Alterations 675 672 142 PMC8548824__F3 Cabozantinib for HCC Treatment, From Clinical Back to Experimental Models 558 5979 2322 2475 PMC8553480__F3 MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer 406988 1740 407010 5728 581 1499 6943 4319 4313 4089 120892 7422 864 9839 6935 PMC8553772__F7 Schematic demonstrating p32 regulates melanoma via AKT/PKB signaling 595 1000 4318 999 PMC8554124__F9 Systematic Review of Transcriptional Dysregulation in Huntington’s Disease Studied by RNA Sequencing 3337 3304 3315 PMC8554658__F1 Molecular mechanisms of chemo‐ and radiotherapy resistance and the potential implications for cancer treatment 3717 6774 894 1499 1956 PMC8557044__F1 Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury 2879 23657 10162 4015 55240 PMC8567165__F5 Proteomic identification of ruminal epithelial protein expression profiles in response to starter feed supplementation in pre-weaned lambs 9590 3158 9260 2040 10631 6223 6201 1491 213 960 1073 27295 171024 7791 PMC8568546__F1 RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A 4838 4087 4088 9589 56339 79068 57721 PMC8568984__F4 Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin 6521 771 358 6005 PMC8569340__F2 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy 5170 3845 1499 PMC8572421__F1 Contradictory roles of lipid metabolism in immune response within the tumor microenvironment 2194 3156 948 4023 355 PMC8576330__F6 Involvement of the TGFB Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis 207 2735 117581 10716 4088 4313 4318 3589 PMC8577020__F5 P53 family member p73 in the regulation of cell stress response 5211 2539 26227 29968 27165 PMC8578048__F2 Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress 147093 100316868 100506046 64750 283120 1277 100507098 5728 4089 7185 1874 5163 5164 100750246 PMC8578301__F1 Clinical and biochemical footprints of inherited metabolic diseases. VI. Metabolic dermatoses. 83401 64834 6785 126410 10999 204219 7357 285848 2531 9517 10558 55304 26154 26227 29968 5723 121214 59344 242 PMC8578378__F1 IL-17 signaling pathway in mucosal candidiasis 3605 84818 6279 3716 7297 PMC8579463__F8 miR-34a-5p functions as a tumor suppressor in head and neck squamous cell cancer progression by targeting Flotillin-2 2319 999 1021 1000 1019 PMC8579641__F1 Regulatory mechanism of neutrophil extracellular traps in cancer biological behavior 1075 7099 3579 6850 6714 7124 3146 8737 PMC8581873__F2 Expression and crucial role of long non-coding RNA FGD5-AS1 in human cancers 100505641 53834 1655 7465 PMC8582492__F1 Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A 8115 3725 2353 5800 87178 472 613 4067 6850 7535 1788 PMC85825__F9 Model illustrating the relative positioning of aPKC within the NGF signaling cascades for survival and differentiation 4803 4804 6714 5163 PMC8584169__F2 Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease 1524 627 6376 54209 PMC8584200__F3 Rho/ROCK Pathway and Noncoding RNAs: Implications in Ischemic Stroke and Spinal Cord Injury 10371 8829 387 23476 7474 PMC8585639__F4 Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets 7099 51135 4615 114609 3656 7189 8737 7187 3661 3663 7098 51284 3654 3665 51311 PMC8585639__F6 Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets 637 59272 114548 79792 3553 6868 11035 PMC8586418__F1 Recent Progress in Interferon Therapy for Myeloid Malignancies 3716 7297 6772 6773 10379 355 7124 7186 29110 115004 3661 3665 PMC8591115__F7 KRAS mutation: from undruggable to druggable in cancer 3845 2475 3265 3667 PMC8591231__F5 Review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury 355 8772 3479 3480 3667 637 572 581 PMC8594875__F8 S-nitrosoglutathione reductase (GSNOR) deficiency accelerates cardiomyocyte differentiation of induced pluripotent stem cells 1482 2932 1499 999 PMC8599256__F2 Endogenous estrogens—breast cancer and chemoprevention 1543 1545 1544 1312 PMC8600311__F2 Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases 367 1969 6010 3172 4280 6275 PMC8601834__F2 Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases 8772 355 7124 8717 637 317 581 331 11035 PMC8604912__F7 Molecular mechanism by which Lactobacillus spp. regulate the core fucosylation of epithelial cellsthrough the Wnt pathway 1499 2530 7473 PMC8607235__F4 SOCS proteins and their roles in the development of glioblastoma 6772 23239 8805 1950 5163 2932 6774 9021 PMC8607587__F1 Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages 22943 3479 6120 PMC8608404__F3 REV7 controls pathway choice at DSBs 112441434 9319 149840 54537 672 PMC8611092__F5 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression 693221 5979 4811 PMC8612001__F3 Epigenetic modifications in thymic epithelial cells: an evolutionary perspective for thymus atrophy 4087 999 1000 81029 54361 PMC8613644__F2 Cell-free network communication in alcohol-associated disorders and liver metastasis 84335 104 1410 7538 7039 2017 23086 94121 9146 10855 6386 3064 9367 5339 84932 5873 5874 PMC8615218__F3 Siglecs as Therapeutic Targets in Cancer 9021 6714 6850 PMC8616386__F2 Walking down Skeletal Muscle Lane: From Inflammasome to Disease 3553 114548 10628 57506 3586 79792 PMC8616424__F1 Dissecting the Crosstalk between Endothelial Mitochondrial Damage, Vascular Inflammation, and Neurodegeneration in Cerebral Amyloid Angiopathy and Alzheimer’s Disease 581 637 54106 115004 948 114548 3553 PMC8616597__F3 Transcriptome analysis reveals disruption of circadian rhythms in late gestation dairy cows may increase risk for fatty liver and reduced mammary remodeling 154 1408 5187 PMC8616751__F2 Therapeutic targeting opportunities in cancer cases with RSPO overactivation 4040 4041 84133 54894 100187761 55366 8549 59352 64840 324 PMC8617942__F2 Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus 9021 3952 6774 5443 3953 3717 4852 PMC8618211__F2 Clinical Manifestations, Pathogenesis, Diagnosis and Treatment of Peripheral Neuropathies in Connective Tissue Diseases: More Diverse and Frequent in Different Subtypes than Expected 4803 7124 717 721 718 1178 23152 PMC8618769__F5 Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases 23621 351 847 590 43 PMC8619244__F5 TRPV4 Mechanotransduction in Fibrosis 5879 6722 50507 59341 6010 PMC8621344__F2 Mitochondrial Dysfunction in Cancer Cachexia: Impact on Muscle Health and Regeneration 5081 100653365 5978 PMC8622894__F2 Plasma Ceramides Pathophysiology, Measurements, Challenges, and Opportunities 1674 64781 10087 6611 6609 6610 55512 PMC8623546__F6 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease 6772 6778 6774 PMC8625721__F1 NLRP3 Inflammasome in Lupus Nephritis 7097 7099 7189 4615 4790 3656 3654 51135 114548 3466 PMC8625891__F1 Type of Fat in the Diet Influences Regulatory Aminopeptidases of the Renin-Angiotensin System and Stress in the Hypothalamic-Pituitary-Adrenal Axis in Adult Wistar Rats 7200 7054 4852 1636 PMC8630233__F6 Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity 3929 3654 4615 51135 7099 7189 PMC8630469__F1 Wnt/Beta-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways 81861 1499 324 2932 3952 100499166 PMC8630697__F3 Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer 2879 3845 55669 9927 PMC8632547__F3 Hippo Signaling Pathway: The Trader of Tumor Microenvironment 7003 8463 7004 7005 2919 6347 6374 3579 PMC8635240__F8 VDR Signaling via the Enzyme NAT2 Inhibits Colorectal Cancer Progression 7421 10 3716 6774 PMC8637208__F5 Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function 1499 387 9113 26524 2534 4485 PMC8638142__F10 LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway 130572098 7528 9088 324 6657 PMC8639599__F1 Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia 7066 4352 1000 4851 6348 9242 PMC8641375__F7 Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice 4615 7099 5868 3553 PMC8645962__F1 Acetylation in Tumor Immune Evasion Regulation 10013 51564 23410 22933 3065 9759 55869 3716 3717 79885 3458 10014 100188864 3066 23411 50943 83933 23409 23408 51548 51547 8841 PMC8650121__F1 Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol 7222 759 54822 7225 54795 80036 PMC8650508__F6 Salvianolic acid B targets mortalin and inhibits the migration and invasion of hepatocellular carcinoma via the RECK/STAT3 pathway 8434 6774 4318 4313 1000 999 PMC8656474__F2 Molecular Mechanisms of Resistance to Immunotherapy and Antiangiogenic Treatments in Clear Cell Renal Cell Carcinoma 3458 1499 8205 3902 324 941 1493 3659 PMC8657577__F1 Genetic Variants of the NFKB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease 7133 7132 7124 79092 5970 5966 PMC8660623__F8 Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway 860 4090 4086 2475 7450 PMC8663982__F2 Cytokine signaling inhibition on inflammation-driven tissue remodeling 114548 3654 7099 664616 23118 10454 7189 PMC8663982__F3 Cytokine signaling inhibition on inflammation-driven tissue remodeling 7099 8717 10333 57154 2475 PMC8665538__F5 Comparative analysis of aneurysm subtypes associated genes based on protein–protein interaction network 114548 91662 834 837 838 3553 3606 PMC8666286__F9 CoCrMo‐Nanoparticles induced peri‐implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2‐ARE signalling pathway 23657 6520 2879 PMC8666374__F1 Schematic diagram showing common components and pathways driving cirrhosis-associated immune dysfunction and novel coronavirus-related disease 920 3458 929 1636 PMC8666534__F5 Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer 2146 10365 406947 2252 60312 5728 PMC8669293__F4 Profound changes in cerebrospinal fluid proteome and metabolic profile are associated with congenital hydrocephalus 10840 1356 4145 2324 3320 4916 PMC8671602__F2 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity 57062 54505 55601 1665 80352 7189 1655 7919 57506 7187 1660 9416 56919 9879 3661 1656 91351 23020 54606 PMC8675856__F8 Long non‐coding RNAs and their targets as potential biomarkers in breast cancer 91355 401904 11283 4051 27097 PMC8684233__F3 Ferroptosis in urologic malignancies 3315 2475 2879 56666 PMC8684614__F4 Epigenetic modification and BRAF gene mutation in thyroid carcinoma 595 673 5728 PMC8686517__F1 TNFA in MS and Its Animal Models: Implications for Chronic Pain in the Disease 11035 197259 8772 8737 8717 7186 7185 PMC8688947__F1 High-Fat Diet-Induced Renal Proximal Tubular Inflammatory Injury: Emerging Risk Factor of Chronic Kidney Disease 79094 90865 768219 6761 7040 729230 948 7099 114548 8841 4615 2475 PMC8692109__F8 Human Alpha-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway 50619 890 1956 1950 PMC8698202__F2 Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms 7297 3716 6772 6773 83939 6041 PMC8698543__F3 Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells 7124 8772 8717 355 637 581 PMC8698632__F3 Association of Circulating Heme Oxygenase-1, Lipid Profile and Coronary Disease Phenotype in Patients with Chronic Coronary Syndrome 255738 338 335 PMC8699390__F3 Of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges 7189 89122 85363 373 7706 117854 10206 6737 135644 81603 83737 10346 10475 84851 9830 4591 22954 81844 5971 PMC8699546__F6 Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation 3146 114609 4615 7099 100133941 PMC8700067__F3 Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease 7099 114609 4615 10133 5071 65018 8878 64786 3312 PMC8700621__F4 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease 545 7124 3624 5309 9048 23237 7475 9965 2895 1959 79977 5308 6926 57057 6899 64843 PMC8703004__F2 Alterations in Lysosome Homeostasis in Lipid-Related Disorders: Impact on Metabolic Tissues and Immune Cells 324 613 948 55364 PMC8703113__F3 Caveolin-1 Regulates Cellular Metabolism: A Potential Therapeutic Target in Kidney Disease 857 5289 2475 PMC8703190__F1 Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain 2735 6469 6608 6295 PMC8704679__F2 JAK-STAT Pathway: A Novel Target to Tackle Viral Infections 1843 729 10379 PMC8706317__F2 Improving the Health-Benefits of Kales (Brassica oleracea L. var. acephala DC) through the Application of Controlled Abiotic Stresses: A Review 9817 2810 367 PMC8708027__F6 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review 578 1956 6395 23411 1019 1021 4170 6659 1870 3690 PMC8711145__F2 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis 64127 114548 7124 140609 846 222545 79792 129607 10628 57506 PMC8711145__F6 Spotlight on NLRP3 Inflammasome: Role in Pathogenesis and Therapies of Atherosclerosis 4615 7097 7099 114548 140609 8737 8772 3553 PMC8712397__F5 Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease 8473 10155 1283 PMC8712868__F2 Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases 7249 6009 2475 2308 3553 56947 8817 860 PMC8713066__F1 Gut microbiota and probiotics on Alzheimer’s disease 929 7099 114609 4615 PMC8714735__F3 IL-6/STAT3 Is a Promising Therapeutic Target for Hepatocellular Carcinoma 6774 174 4072 100133941 7852 6714 PMC8715300__F12 Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome 920 4321 1825 53905 3627 PMC8718643__F3 Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium 7249 2932 9882 PMC8719288__F1 Building Resilience with Aerobic Exercise: Role of FKBP5 2638 627 2922 PMC8721005__F8 Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway 9927 1998 468 PMC8721920__F1 Interferon Control of Human Coronavirus Infection and Viral Evasion: Mechanistic Insights and Implications for Antiviral Drug and Vaccine Development 4615 51311 51284 29110 3665 3661 57506 10010 3716 10379 3454 7297 6773 6772 3437 3433 3434 972 9023 4061 684 115004 11274 3455 4938 4939 PMC8722298__F1 Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer 146223 389421 100302142 100302276 5155 8091 59 PMC8728363__F6 Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer 961 100133941 958 3466 729230 1234 PMC8730700__F3 Serum Analyte Profiles Associated With Crohn’s Disease and Disease Location 3559 6387 4283 2919 3576 6356 3082 PMC8733707__F7 ENO3 Inhibits Growth and Metastasis of Hepatocellular Carcinoma via Wnt/Beta-Catenin Signaling Pathway 1499 2932 2027 4313 4316 4318 595 PMC8733961__F4 5q35 duplication presents with psychiatric and undergrowth phenotypes mediated by NSD1 overexpression and mTOR signaling downregulation 64324 7249 2475 PMC8738926__F4 Starvation-induced negative energy balance on endoplasmic reticulum stress in the liver of cows 7494 4703 5465 51 3158 PMC8739177__F3 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF 10499 4318 4313 5159 3815 5979 3791 6462 3569 7124 3558 7157 3486 3294 2100 4363 7298 31 152 1576 196 1557 367 1545 1544 1588 1586 581 PMC8742202__F5 SMAD4 contributes to chondrocyte and osteocyte development 5745 5744 4089 860 1499 3549 4040 4041 6662 8322 4086 PMC8742232__F2 Advances in the study of CDC42 in the female reproductive system 5728 4193 135935 PMC8744307__F2 Inflammasomes in vascular cognitive impairment 22861 114548 9447 58484 3586 79792 PMC8748963__F9 NLK/SRF/ELK Pathway 6010 6722 7414 51701 1958 PMC8750552__F7 Ginsenoside Rg3 Attenuates TNF-Alpha-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms 581 596 23410 23411 PMC8755543__F7 Mechanism diagram of KDM4A-AS1 regulating the degradation of AR/AR-Vs 4193 367 9097 100132774 PMC8755678__F3 Endothelium function by fatty acids 7422 54567 4851 5209 10365 1374 2308 4609 PMC8761221__F1 Autophagy regulatory pathways 3562 2475 8408 9706 7249 7248 PMC8762245__F2 Exosomes Regulate NLRP3 Inflammasome in Diseases 9242 51099 114548 140609 PMC8762717__F9 PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature 140609 114548 3553 PMC8764312__F1 Novel Targets and Therapeutic Strategies to Protect Against Hepatic Ischemia Reperfusion Injury 3569 7099 114548 2932 4615 60343 2534 PMC8766746__F5 Robo2 and Gen1 Coregulate Ureteric Budding by Activating the MAPK/ERK Signaling Pathway in Mice 6092 9353 5979 2674 348654 2668 26585 2119 PMC8770807__F1 Hypomethylating Agent-Based Combination Therapies to Treat Post-Hematopoietic Stem Cell Transplant Relapse of Acute Myeloid Leukemia 6850 2322 3458 50943 PMC8771504__F6 Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through B2-AR/ERK/EMT pathway 999 1000 6935 PMC8771506__F6 POU4F3 Acts as a Tumor Suppressor in Lung Adenocarcinoma via the Endoplasmic Reticulum Stress Signaling Pathway 5459 468 83939 PMC8772740__F6 Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation 387 8829 5879 PMC8772744__F2 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease 8408 2475 5728 PMC8773732__F1 Macrophage Involvement in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Comprehensive, Short Review 3553 3458 7099 7124 6772 8651 9021 6010 114548 7189 PMC8776063__F13 Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells 551 6790 1072 54434 359 PMC8781453__SF1 Downregulation of the LncRNA MEG3 Promotes Osteogenic Differentiation of BMSCs and Bone Repairing by Activating Wnt/Beta-Catenin Signaling Pathway 22943 1499 55384 PMC8781927__F6 FGFC1 Exhibits Anti-Cancer Activity via Inhibiting NFKB Signaling Pathway in EGFR-Mutant NSCLC Cells 595 1019 7124 PMC8782480__F4 IPA canonical pathway, “Interferon signalling” 581 3458 8554 8651 3659 10379 2695 5696 PMC8786676__F3 Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation 6678 6403 6347 8743 2885 581 960 4609 7157 596 9510 7124 PMC8787094__F1 Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins 79792 57169 57506 4938 6041 7098 51284 8635 6036 4615 3661 51311 6738 115004 81030 11035 114548 197259 PMC8787237__F3 STING1 in sepsis: Mechanisms, functions, and implications 836 340061 3661 PMC8789654__F6 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway 1956 6714 595 836 374 PMC8790872__F7 Novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression 2932 7124 3169 29072 PMC8794746__F1 New Insights into LINC00346 and its Role in Disease 4118 983 891 6774 57418 4609 1499 PMC8797727__F3 p16 a biomarker of aging and tolerance for cancer therapy 1030 1021 1019 4193 PMC8799916__F2 Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures 6608 2736 2737 581 572 1956 2534 6714 780904 PMC8800364__F7 Immunometabolism in biofilm infection: lessons from cancer 948 6774 6778 5465 7124 PMC8801635__F12 Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2/STAT3 signaling pathway 3717 6774 581 213 PMC8802753__F3 Polyphenols and omega-3 PUFAs: Beneficial Outcomes to Obesity and Its Related Metabolic Diseases 3569 3586 3596 PMC8807458__F3 Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering 4087 4088 4089 PMC8807567__F3 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance 9575 406 7465 55294 PMC8807626__F3 Context-dependent modulation of TGFB pathway by LRG1 4087 4088 116844 4090 4086 4089 PMC8814673__F2 Advances in research on the effects of platelet activation in acute lung injury (Review) 5594 6850 7124 6714 PMC8815128__F6 N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NFKB/A20 axis 27161 51441 11201 PMC8817856__F8 ROS/GRK2/HIF-1A/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin 156 3240 79792 PMC8818599__F7 Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting 6774 3717 9021 5163 3667 114907 PMC8821656__F1 Approaches Toward Targeting Matrix Metalloproteases for Prognosis and Therapies in Gynecological Cancer: MicroRNAs as a Molecular Driver 54487 29102 26523 192670 27161 192669 5901 PMC8826420__F7 Proposed molecular mechanisms of ANGPTL7 in CLAN formation in TM cells 6667 387 10218 PMC8827057__F8 Overview diagram describing the mechanism of the inhibitory effect of HF-MSCs on HSCs 1893 4087 4088 4089 PMC8827490__F1 Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens 718 2271 1378 727 729 735 10747 730 717 721 1401 PMC8831284__F3 Transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer’s disease risk 6878 79890 64131 9810 254122 51338 7775 1636 2041 388324 5819 4899 79090 83719 5817 94241 PMC8832734__F1 Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview 112597 2932 1499 283120 PMC8832753__F1 B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages 10113 952 2638 5091 PMC8833361__F8 Time Series Ovarian Transcriptome Analyses of the Porcine Estrous Cycle Reveals Gene Expression Changes during Steroid Metabolism and Corpus Luteum Development 7054 8643 6608 22944 759 596 64399 4036 3240 157 2736 408 409 PMC8833582__F5 Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges 4092 64750 4089 7046 4087 4088 7189 6774 3717 PMC8833974__F5 KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications 2885 3845 50943 920 PMC8834120__F4 Landscape of PDK1 in Breast Cancer 2885 6009 7249 387 23678 347902 PMC8834417__F1 Influence of the Metabolism on Myeloid Cell Functions in Cancers: Clinical Perspectives 3099 3098 3091 2475 PMC8836072__F3 Proliferation and Apoptosis Pathways and Factors in Oral Squamous Cell Carcinoma 572 8739 638 637 90427 597 8772 317 PMC8836080__F1 Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases 50964 4038 6424 4040 4041 PMC8836162__F4 EphrinB2–EphB4 Signaling in Neurooncological Disease 7422 1956 54567 PMC8837098__F1 mTOR Signaling Components in Tumor Mechanobiology 5728 7248 6009 7249 PMC8839664__F6 Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model 3795 7498 4023 23411 3156 10628 2194 7124 1958 688 31 2353 PMC8842579__F4 Battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies 7097 4615 7099 6850 57506 7187 29110 3661 3454 3455 7297 3716 6773 6772 10379 PMC8843879__F3 Critical roles of the lncRNA CASC11 in tumor progression and cancer metastasis: The biomarker and therapeutic target potential 255082 100270680 1316 375295 PMC8847744__F5 Intestinal Infection of Candida albicans: Preventing the Formation of Biofilm by C. albicans and Protecting the Intestinal Epithelial Barrier 572 581 3717 6774 9021 6772 PMC8849213__F2 Protein C Pathway in Paediatric and Neonatal Sepsis 929 7018 3929 3553 3569 7099 5091 PMC8850641__F9 Identification of Potential Blind-Side Hypermelanosis-Related lncRNA–miRNA–mRNA Regulatory Network in a Flatfish Species, Chinese Tongue Sole (Cynoglossus semilaevis) 4286 7306 1638 PMC8850798__F8 Selenium binding protein 1 inhibits tumor angiogenesis in colorectal cancers by blocking the Delta-like ligand 4/Notch1 signaling pathway 54567 4851 8991 3280 PMC8851273__F9 Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling 6774 10006 3717 PMC8851315__F1 Mitochondrial-Derived Peptides in Diabetes and Its Complications 1271 6774 581 637 PMC8854490__F1 Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions 115004 29110 3661 PMC8858844__F1 Pyroptosis: A Developing Foreland of Ovarian Cancer Treatment 9447 58484 114548 79792 55876 1687 3002 3001 PMC8861075__F1 Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease 8564 169355 3620 130013 23475 PMC8861487__F2 Innate Immunity in Natural Elite Controllers of HIV-1 Infection 115004 3661 7097 7099 4615 51311 51284 3665 7189 54106 7098 7187 PMC8863680__F2 Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations 57506 29110 3661 7297 3716 6773 10379 PMC8863767__F11 Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages 7096 7097 7099 3661 3665 3659 10148 7098 9466 3716 3717 9636 3600 6347 6354 PMC8863938__F4 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers 2475 596 581 PMC8866817__F4 CD3+CD4-CD8- (Double-Negative) T Cells in Inflammation, Immune Disorders and Cancer 7124 355 8772 PMC8869442__F2 Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19 55611 78990 1540 7099 7375 9958 11274 7706 9636 57506 3661 3665 8975 PMC8870354__F2 Drug Resistance and Endoplasmic Reticulum Stress in Hepatocellular Carcinoma 7186 7494 22926 23657 468 PMC8870715__F2 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements 8772 637 581 PMC8871376__F1 Adenylosuccinate lyase (ADSL) in de novo purine synthesis (DNPS) and the purine nucleotide cycle 2618 10606 5471 5198 132 158 100 4860 2766 8833 471 PMC8872331__F3 MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma 5728 7157 4193 5156 5925 4763 PMC8873532__F1 Mitochondrial Nucleic Acid Sensing Pathways in Health and Patho-Physiology 468 83939 10730 6742 PMC8873791__F6 Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway 7015 6790 4751 3486 8038 5029 6524 3781 3673 7051 2048 11096 554 9212 PMC8874859__F4 How RSV Proteins Join Forces to Overcome the Host Innate Immune Response 57762 8651 9021 7018 10379 57506 3661 3716 6773 6772 3665 7187 29110 7297 8638 7706 10410 3434 PMC8880314__SF1 Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity 10558 2531 1674 95 427 56624 7357 8877 56848 PMC8883581__F6 Overexpression of MUC1 Induces Non-Canonical TGFB Signaling in Pancreatic Ductal Adenocarcinoma 4089 4582 4087 4088 PMC8883632__F10 Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma 6303 246 29121 3458 2241 PMC8884272__F1 Intriguing Role of TLR Accessory Molecules in Cardiovascular Health and Disease 3929 9865 948 7099 29110 7187 3661 10333 3064 4615 3654 51135 7189 23118 257397 7096 7097 7448 PMC8884404__F1 Molecular Pathways of Pyroptosis in Atherosclerosis 387 79792 114548 9447 PMC8885627__F1 Macrophages and Metabolic Reprograming in the Tumor Microenvironment 6387 3550 3576 PMC8889079__F1 NLRP3 Inflammasome in Alzheimer’s Disease and Potential Therapeutic Targets 4615 114548 79792 PMC8892718__F3 Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions 85480 6761 90865 920 196 6778 10344 PMC8892735__F4 Long and short non-coding RNAs modulating EZH2 signaling in cancer 1871 1786 7528 6659 6927 4323 2146 25855 7852 3099 PMC8894956__F4 First-line immunotherapy or angiogenesis inhibitor plus chemotherapy for HER2-altered NSCLC: a retrospective real-world POLISH study 3458 115004 29110 3661 PMC8895457__F7 Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma 4609 596 581 PMC8898375__F10 Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway 25923 23410 23411 1374 PMC8900001__F1 Glycolysis in the progression of pancreatic cancer 2669 3845 115426 10419 7385 PMC8900870__F1 Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions 6714 24145 9722 PMC8901478__F2 Talimogene Laherparepvec: Moving From First-In-Class to Best-In-Class 3716 7297 115004 3717 7124 5447 3661 PMC8901637__F6 Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased B2 adrenergic agonist 1499 5210 2932 3939 2736 6010 9113 26524 4316 4170 329 9290 PMC8902450__F8 Gallic Acid Hindered Lung Cancer Progression by Inducing Cell Cycle Arrest and Apoptosis in A549 Lung Cancer Cells via PI3K/Akt Pathway 581 595 898 PMC8904921__F5 Green Tea Polyphenols Upregulate the Nrf2 Signaling Pathway and Suppress Oxidative Stress and Inflammation Markers in D-Galactose-Induced Liver Aging in Mice 7124 9817 4094 1728 847 PMC8909644__F3 Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming 2946 2744 952 PMC8909695__F2 Organic UV Filters Induce Toll-like-Receptors and Related Signaling Pathways in Peripheral Blood Mononuclear Cells of Juvenile Loggerhead Sea Turtles (Caretta caretta) 6418 4025 7096 7097 5879 10000 PMC8909726__F6 Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma 3185 1977 100187761 7398 4318 PMC8909868__F3 Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma 6774 4087 7225 PMC8910759__F3 Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders 7189 140609 114548 960 PMC8911352__F2 Paediatric Behçet’s Disease: A Comprehensive Review with an Emphasis on Monogenic Mimics 8737 8717 5970 90268 613 81858 PMC8913496__F1 RhoG’s Role in T Cell Activation and Function 324 57620 391 6786 84876 80228 3716 3575 3718 PMC8914339__F1 Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer 55240 3315 8031 3162 9817 PMC8914339__F2 Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer 2879 2746 2182 10162 4015 PMC8918193__F7 S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3B and CK1A 324 2932 1499 140576 3082 PMC8919059__F6 Genomic And Tumor Microenvironment Differences Between Cell Cycle Progression Pathway Altered/Non-Altered Patients With Lung Adenocarcinoma 91646 140690 1029 112714 2069 100616460 100847064 3623 5596 3552 3952 3481 131405 8929 3135 171484 247 PMC8920937__F8 TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway 64114 572 836 581 PMC8921549__F3 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury 5925 8772 355 637 581 PMC8923702__F7 Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGFB/SMAD Signaling Against Candida albicans Infection 4087 4088 920 4089 6774 3717 3718 9021 PMC8929255__F4 Immune barriers in haematopoietic stem cell gene therapy 115004 472 7124 3458 PMC8931781__F1 Biological Activity of 3-O-Acetyl-11-keto-Beta-Boswellic Acid in Nervous System Diseases 7099 9817 1647 3553 PMC8933076__F1 Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases 1581 80270 1582 1593 25801 9420 4280 PMC8934560__F3 Nourishing Better Vision: The ARVO 2021 Mildred Weisenfeld Award Lecture 60481 54898 1674 64834 83401 6785 PMC8935230__F8 Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/GAi2/YAP signaling 4544 5447 9113 176 1280 PMC8938281__F10 MiR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate Cells 4089 4090 4086 4091 2113 4015 3673 4087 4088 7042 3678 4092 PMC8938720__F6 Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway 6774 116844 4090 4086 285 4089 2022 PMC8948417__F4 RET receptor signaling: Function in development, metabolic disease, and cancer 9518 389400 5979 4922 PMC8949786__F5 Characterization of Accessible Chromatin Regions in Cattle Rumen Epithelial Tissue during Weaning 4086 596 5898 4088 4091 7048 4087 4092 56937 7042 3624 3625 2353 6885 6300 5605 3845 22800 5594 23090 3172 3623 PMC8950247__F3 Polymorphisms and Gene-Gene Interaction in AGER/IL6 Pathway Might Be Associated with Diabetic Ischemic Heart Disease 8543 51752 3716 3572 1270 177 8554 3055 6439 10401 3684 3146 5791 3569 5970 4790 PMC8954347__F1 LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection 3661 7099 4615 7097 10333 51135 3654 7189 54106 6850 64170 8915 10892 3553 PMC8957101__F1 Hidden One: What We Know About Bitter Taste Receptor 39 5330 29850 54795 255022 119395 PMC8958685__F6 Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies 19 948 3569 255738 7099 581 PMC8959654__F1 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC 283120 3192 619501 100124700 378938 1499 6426 PMC8960167__F2 Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy 2182 10162 246 2879 4780 23657 9131 142 PMC8961331__F3 Interplay Between TGFB Signaling and Cell Metabolism 367 8877 427 259230 PMC8961531__F3 Neurobiological and Pharmacological Perspectives of D3 Receptors in Parkinson’s Disease 2475 5173 23237 627 PMC8961787__F1 Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension 2539 3939 39 38 948 2180 6510 8140 31 PMC8963791__F1 Pathways leading to generation of disease biomarkers in NPC 4864 10577 325 PMC8964056__F4 Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling 23002 387 4920 4919 5879 PMC8964740__F2 Main mechanisms of miR-31 in oral squamous cell carcinoma (OSCC) 26524 79971 387 407035 1956 8650 23410 PMC8964769__F6 Publisher Correction: Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway 6774 116844 4090 4086 285 4089 2022 PMC8965895__F2 Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways 4040 1499 367 22943 PMC8966655__F6 Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway 23657 59330 2879 PMC8968815__F1 Wnt/Beta-catenin signaling pathway related microRNAs in esophageal cancer 6424 1017 84133 1499 27122 147906 2932 100422929 27123 6774 PMC8977221__F1 Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook 619501 940 941 100379198 325 PMC8977417__F2 Biological Characteristics and Clinical Significance of Soluble PD-1/PD-L1 and Exosomal PD-L1 in Cancer 325 942 940 941 2475 54908 PMC8979868__F2 Novel insights on GM1 and Parkinson's disease: A critical review 7357 51083 9334 8869 8705 6483 6762 29906 6489 PMC8979960__F7 Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease 56848 29956 9517 259230 6609 2581 PMC8983057__F5 Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation 6010 1839 3579 3383 3577 7412 PMC8985313__F8 Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling 2357 2358 301 6774 6772 PMC8985609__F2 Activation of the non-canonical NLRP3 inflammasome 7099 114548 3553 PMC8988234__F3 Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance 23657 6520 5627 2621 7301 2879 PMC8990928__F1 Genotype-Guided Prescription of Azathioprine Reduces the Incidence of Adverse Drug Reactions in TPMT Intermediate Metabolizers to a Similar Incidence as Normal Metabolizers 7498 7172 55270 PMC8992594__F3 Emerging actionable targets to treat therapy-resistant colorectal cancers 285 7422 673 7048 94 PMC8994563__F7 Targets Exploration of Hydroxychloroquine for Pigmentation and Cell Protection Effect in Melanocytes: The Clue for Vitiligo Treatment 4157 5409 4286 5077 10399 6663 43 79083 5873 4644 6490 253827 57654 63915 84062 PMC8997905__F2 Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases 114548 7124 7097 7099 23098 2357 64127 3553 6850 PMC8997978__F4 Label-Free LC-MS/MS Analysis Reveals Different Proteomic Profiles between Egg Yolks of Silky Fowl and Ordinary Chickens 183 8620 4852 551 51052 2834 PMC8998551__F4 Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution 5979 5156 3815 2475 2322 PMC8998760__F1 Interplay between PARP Inhibitors and Immunotherapy in Ovarian Cancer: The Rationale behind a New Combination Therapy 2932 115004 3661 PMC9001126__F7 Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway 4318 9242 578 PMC9003967__F11 Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGFB/SMAD3 signaling pathway 5111 595 4088 4313 4322 999 1000 PMC9005797__F1 Holistic Approach to Immune Checkpoint Inhibitor-Related Adverse Events 324 941 942 940 PMC9006576__F1 Emerging role of RNA sensors in tumor microenvironment and immunotherapy 57506 64127 7187 29110 7098 3661 51311 51284 4615 7189 3665 PMC9008451__F2 Interleukin-22 in Renal Protection and Its Pathological Role in Kidney Diseases 196 7099 7097 6774 572 114548 6347 3627 PMC9013399__F1 Significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease 23475 130013 93100 10135 4837 PMC9013942__F3 Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms 581 6714 3716 3717 6774 407009 1869 595 7852 9475 PMC9016174__F1 Endometriosis-Associated Angiogenesis and Anti-angiogenic Therapy for Endometriosis 1499 324 2932 PMC9020986__F4 Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies 729230 91937 3558 2627 1236 PMC9021242__F2 Hippo signaling pathway in ALI 9294 1003 4313 7477 2255 PMC9021242__F6 Hippo signaling pathway in asthma 7808 85480 7124 6364 324 182 4855 64806 90865 9294 PMC9021375__F8 Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis 4018 7099 929 4615 PMC9021824__F2 miR-1908 Dysregulation in Human Cancers 4208 3727 6428 28511 5728 PMC9022980__F1 TNF-induced necroptosis occurs when upstream pro-survival and pro-apoptotic pathways are inhibited 7124 8717 8737 7186 717 11035 8772 PMC9024684__F2 Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease 146433 5764 1499 2534 PMC9026097__F9 Transcriptomic Analysis of Fumarate Compounds Identifies Unique Effects of Isosorbide Di-(Methyl Fumarate) on NRF2, NF-kappaB and IRF1 Pathway Genes 4094 3162 3383 3576 3659 3569 837 PMC9026123__F1 Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease 55270 7172 8833 PMC9027975__F2 Interplay between Viruses and Host DNA Sensors 3665 4615 51135 3654 7189 7187 3656 PMC9028838__F1 MicroRNAs: Novel Targets in Hepatic Ischemia–Reperfusion Injury 8651 100126354 23411 4088 23410 4089 5469 7077 390 7189 823 4082 7852 PMC9029764__F2 Dangerous Liaisons in the Oxidative Stress Response to Leishmania Infection 3569 3627 6352 7098 207 PMC9030253__F4 Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals 581 847 472 355 8772 PMC9034917__F9 Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment 3553 581 596 PMC9035226__F6 Summary & conceptualized pathway 3717 3397 58480 2919 595 983 860 57154 PMC9044760__F2 RIPK3-mediated necroptotic pathway 355 8717 7186 8772 197259 PMC9046588__F4 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy 7189 57506 3275 54496 10196 3661 3665 PMC9046588__F5 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy 3428 3276 55170 115004 3661 10419 29110 3665 PMC9047489__F1 Epithelial-Mesenchymal Transition-Inducing Factors Involved in the Progression of Lung Cancers 4088 4087 2932 2303 999 PMC9048097__F9 Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/Beta-catenin/MDR1 signaling axis by upregulating miR-384 494333 5764 238 1499 2932 324 PMC9060113__F2 Targeting the PI3K/Akt signaling pathway in pancreatic B‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes 7124 3553 3458 PMC9060145__F4 Preclinical assessment of dual CYP26[A1/B1] inhibitor, DX308, as an improved treatment for keratinization disorders 8168 7351 5341 5624 7431 PMC9071071__F3 Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine 23492 8726 23411 3814 PMC9074815__F4 Neuronal Redevelopment and the Regeneration of Neuromodulatory Axons in the Adult Mammalian Central Nervous System 84894 386724 6010 10371 PMC9077852__F9 Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/Beta-catenin pathway 9493 11091 1499 2305 PMC9078761__F7 Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer's Disease 7222 6311 6622 27429 5173 23621 120892 4287 581 7415 9217 841 842 PMC9081430__F1 Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases 860 9242 4772 6774 1749 3553 PMC9086356__F1 Innate Lymphoid Cells in Cancer Development and Immunotherapy 8320 3398 2625 4783 9760 196 1235 PMC9094400__F1 Targeting PARP1 to Enhance Anticancer Checkpoint Immunotherapy Response: Rationale and Clinical Implications 6352 3627 115004 PMC9094424__F1 Inborn Errors of the Immune System Associated With Atopy 2312 1041 1828 85480 90865 920 64806 PMC9094424__F2 Inborn Errors of the Immune System Associated With Atopy 920 3572 6774 84905 81704 7456 10095 84433 8915 10892 7535 27040 PMC9095358__F9 Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NFKB Signaling Pathway Affects Chondrocyte Pyroptosis 4615 79792 114548 PMC9095530__F2 Molecular insights into the pathophysiology of doxorubicin-induced cardiotoxicity: a graphical representation 7124 8717 8772 11035 197259 717 6774 PMC9095829__F8 TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases 1365 7494 59341 22926 468 PMC9095977__F3 Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse 6387 7852 100187761 3146 6651 PMC9097798__F1 Development of novel agents for the treatment of early estrogen receptor positive breast cancer 8205 1950 1956 2475 PMC9097844__F8 ASIC1a stimulates the resistance of human hepatocellular carcinoma by promoting EMT via the AKT/GSK3B/Snail pathway driven by TGFB/Smad signals 2932 4313 4318 619501 PMC9099768__F1 Obesity as a Risk Factor for Dementia and Alzheimer’s Disease: The Role of Leptin 9021 3717 6774 2475 PMC9099915__F2 Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way? 8320 6910 2626 PMC9102269__F9 Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver 5243 283871 8766 8411 PMC9105027__F2 Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis 4040 4041 324 1499 9507 11096 4314 4318 4322 10216 PMC9105874__F1 Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors 8772 841 8737 11035 114548 834 54822 197259 3553 3606 79792 717 PMC9105874__F2 Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors 51393 7226 56262 79792 3553 3606 5335 PMC9112456__F3 Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives 60674 100506495 283131 100302203 400931 407009 6608 51684 100124700 693221 440894 400500 151009 646576 55000 378805 642587 100506385 PMC9115561__F2 RNA Therapeutic Options to Manage Aberrant Signaling Pathways in Hepatocellular Carcinoma: Dream or Reality? 7852 4193 6347 729230 7015 1956 2475 4609 10123 332 1499 PMC9118092__F8 Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling 140809 7352 343 51330 2251 4056 1571 6423 2660 139065 11197 58498 PMC9119167__F2 Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins 4598 3652 10858 1593 1576 9023 51302 9420 PMC9119167__F4 Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins 4864 19 9619 5007 5763 PMC9120629__F1 Complement Dependent Synaptic Reorganisation During Critical Periods of Brain Development and Risk for Psychiatric Disorder 716 717 721 1431 730 729 735 PMC9120866__F5 Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae 9636 27338 7726 84727 10346 9830 140691 PMC9123807__F1 Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents 9636 3659 57762 PMC9126727__F4 Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking 5747 7157 1277 5743 PMC9130572__F2 Pyroptosis: Role and Mechanisms in Cardiovascular Disease 79792 114548 3146 PMC9133079__F3 Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells 7301 558 10461 208 5291 5519 3716 3717 3718 6772 6773 6774 6775 6778 8651 9021 3456 29121 3685 3454 3455 5879 PMC9136457__F1 When PIP2 Meets p53: Nuclear Phosphoinositide Signaling in the DNA Damage Response 5728 56623 253430 23236 PMC9136877__F6 Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design 1003 5879 558 6714 284 PMC9138239__F1 Key Molecules of Fatty Acid Metabolism in Gastric Cancer 47 947 7913 2932 1499 2194 2735 2475 355 1051 10866 66037 PMC9138510__F1 TGFB as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications 4092 7048 4087 4088 7018 7046 4089 PMC9139316__F1 Detecting DNA: An Overview of DNA Recognition by Inflammasomes and Protection against Bacterial Respiratory Infections 3661 114548 9447 838 837 834 140609 81030 3428 29110 3553 115004 11035 79792 PMC9141839__F7 Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1/p53 Pathway 2098 991 55143 PMC9144171__F3 Endocardial Regulation of Cardiac Development 57057 23462 23493 4851 4878 6909 6926 650 3037 1462 10631 26508 7042 4488 4487 7291 27302 7422 2064 2066 9510 9464 3084 PMC9146244__F2 Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System 627 1499 4803 PMC9147606__F2 Endothelial Dysfunction Induced by Extracellular Neutrophil Traps Plays Important Role in the Occurrence and Treatment of Extracellular Neutrophil Traps-Related Disease 7018 5966 7097 7099 54106 4353 51284 3553 114548 PMC9147606__F3 Endothelial Dysfunction Induced by Extracellular Neutrophil Traps Plays Important Role in the Occurrence and Treatment of Extracellular Neutrophil Traps-Related Disease 4353 1499 1003 7018 PMC9157004__F4 High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype 6480 2523 2524 8028 51804 4487 57335 10317 8706 53947 84002 2583 6489 2525 8869 1044 2114 6927 3172 2122 4602 10402 PMC9157490__F3 Prospective Medicinal Plants and Their Phytochemicals Shielding Autoimmune and Cancer Patients Against the SARS-CoV-2 Pandemic: A Special Focus on Matcha 7099 7097 4015 5478 PMC9161355__F1 Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer 967 928 3732 975 PMC9162453__F1 Heme biosynthetic pathway 2235 23456 7389 7390 4118 130749 90523 3145 PMC9163972__F10 Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐KB Signaling Pathway 6354 6347 729230 PMC9165556__F1 Deleterious Genetic Variation Across the NOD Signaling Pathway Is Associated With Reduced NFKB Signaling Transcription and Upregulation of Alternative Inflammatory Transcripts in Pediatric Inflammatory Bowel Disease 64127 64170 114548 8767 330 329 331 83737 55364 29108 3606 3553 55054 1432 5599 PMC9166579__F8 Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/Beta-catenin signaling pathway in mice 4040 4041 1499 324 2932 3479 3480 27122 3486 PMC9166621__F8 Systematic Review and Meta-Analysis of Phytoestrogen Protects Against Myocardial Ischemia/Reperfusion Injury: Pre-Clinical Evidence From Small Animal Studies 7099 114548 387 581 10869 PMC9168599__F8 Activation of PI3K/p110A in the Lung Mesenchyme Affects Branching Morphogenesis and Club Cell Differentiation 6662 2255 3670 3280 5728 PMC9171412__F3 DNA damage initiates inflammatory signaling through DDR and cGAS‐STING. ATM‐NF‐kB pathway 472 3661 115004 29110 7189 3656 3654 4615 114548 51135 834 54106 PMC9175089__F6 Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling 1950 3845 387 5879 998 PMC9180643__F3 Monoubiquitination in Homeostasis and Cancer 8841 4193 5111 6596 4089 PMC9180737__F2 GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease 7474 6615 7431 148979 2260 84662 PMC9180737__F3 GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease 200894 8842 84662 2735 6774 PMC9181689__F2 Enhancing the Therapeutic Potential of Mesenchymal Stromal Cell-Based Therapies with an Anti-Fibrotic Agent for the Treatment of Chronic Kidney Disease 7124 3553 1636 4092 PMC9185832__F1 Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes 3606 3002 3458 4615 PMC9185982__F6 SRF: a seriously responsible factor in cardiac development and disease 6722 8805 93649 22954 9314 9759 27289 387 4088 2932 1499 PMC9198215__F2 Sirtuins in Osteogenic Differentiation of Vascular Smooth Muscle Cells and Vascular Calcification 860 1499 23411 472 23410 51548 PMC9200548__F3 Novel Therapeutic Strategies for Ischemic Stroke: Recent Insights into Autophagy 7249 2475 8408 25976 PMC9200993__F1 Treg Cell Metabolism and Function in Non-Lymphoid Tissues 1499 6775 940 7019 2645 90865 2625 10538 3662 PMC9201217__F1 Toll-Like Receptors in Radiotherapy- and Chemotherapy-Induced Oral Mucositis: A Concise Review 7124 3146 4615 PMC9202199__F6 Power of heteronemin in cancers 595 5111 8772 355 PMC9202199__F8 Power of heteronemin in cancers 6774 596 581 PMC9204297__F2 NLRP3-Dependent Pyroptosis: A Candidate Therapeutic Target for Depression 574436 9447 3949 79792 114548 22861 PMC9204405__F1 Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research 8205 729230 6348 6347 3569 6774 3586 PMC9207338__F1 Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases 7098 7189 7187 29110 3661 51284 51311 4615 54106 3654 3665 115004 114548 9447 3428 3553 PMC9208265__F3 Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy 6347 4025 2879 5594 5595 7097 1788 3146 2475 7099 PMC9210594__F2 Potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review 3082 595 5970 7422 860 5081 648 PMC9218738__F1 The NLRP3 Inflammasome in Mediating Glomerular and Tubular Injury in Diabetic Nephropathy 7099 114548 3603 759 79792 8737 8772 PMC9218900__F3 Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation 6774 64332 3654 51135 7189 3146 5966 114548 79792 PMC9219669__F2 Apoptosis and (in) Pain—Potential Clinical Implications 4803 7124 355 841 836 637 842 596 581 PMC9219813__F2 Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface 1901 9294 1903 8698 6010 53637 PMC9220066__F3 Therapeutic Aspects and Molecular Targets of Autophagy to Control Pancreatic Cancer Management 8408 3845 7249 7248 6009 64798 2475 PMC9220155__F4 Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation 9817 1728 3717 6774 23621 1356 114548 54106 115004 7019 PMC9221026__F2 Translational Regulation in mTOR Pathway 1977 27250 1975 29904 1938 23367 PMC9221189__F5 O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway 4040 4041 8473 1499 6925 4087 4088 4089 2932 6010 9113 26524 28514 54567 PMC9221191__F2 Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response 355 8772 637 581 PMC9221885__F1 New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer’s Disease and Its Potential for Therapeutic Intervention 3661 348 54209 114548 2475 115004 PMC9222488__F1 Clinical and Mutation Spectrum of Autosomal Recessive Non-Syndromic Oculocutaneous Albinism (nsOCA) in Pakistan: A Review 4286 1638 51151 4948 283652 PMC9224204__F4 Chronic LY341495 on Hippocampal mTORC1 Signaling in Mice with Chronic Unpredictable Stress-Induced Depression 627 1977 1975 PMC9225019__F1 Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup 595 2261 4094 894 896 PMC9226665__F6 Endotoxins Induced ECM-Receptor Interaction Pathway Signal Effect on the Function of MUC2 in Caco2/HT29 Co-Culture Cells 1292 3913 387 3685 3371 2335 3381 6714 9475 960 5548 375790 4633 3339 PMC9229940__F3 Toxic Effects and Tumor Promotion Activity of Marine Phytoplankton Toxins: A Review 847 5212 637 PMC9231174__F3 Calcifediol for Use in Treatment of Respiratory Disease 57817 7097 7099 3458 8074 1594 64127 2475 PMC9232569__F7 Targeting signaling pathways in prostate cancer: mechanisms and clinical trials 7474 4919 1499 324 2932 54894 PMC9233348__F1 Cytokines and microRNAs in SARS-CoV-2: What do we know? 9021 5281 7124 59272 PMC9234081__F6 Dietary cholesterol promotes growth and ecdysone signalling pathway by modulating cholesterol transport in swimming crabs (Portunus trituberculatus) 2539 355 8309 55289 51 2170 PMC9239034__F1 Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway 6772 7186 29761 3725 5008 6364 PMC9239764__F9 ARL4C Regulates the Progression of Clear Cell Renal Cell Carcinoma by Affecting the Wnt/Beta-Catenin Signaling Pathway 1499 1000 999 PMC9240646__F7 Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases 3995 8560 7908 10558 6741 123099 242 59344 121214 PMC9242064__F2 Inflammatory bowel disease and cardiovascular diseases: a concise review 2147 2153 7035 PMC9243319__F1 Revisiting chemoresistance in ovarian cancer: Mechanism, biomarkers, and precision medicine 142 10038 3980 8505 PMC9247483__F2 Current Understanding and Management of Plasma Cell Mastitis: Can We Benefit from What We Know? 920 8835 2690 6774 7124 2475 3383 5617 1275 PMC9250793__F1 Signaling pathways in hair follicle stem cells 4040 4041 1499 324 PMC9251540__F2 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review 4855 4853 4851 4854 3280 388585 23493 23462 PMC9251540__F3 SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review 114548 3553 5901 837 838 79792 PMC9253713__AF1 SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway 4485 9113 51684 2182 4771 PMC9253924__F45 Inhibition of anti-inflammatory pathway through suppressors of cytokine signalling (Socs2/Socs3) in the initiation of hepatocellular carcinoma 1544 1571 1543 4615 8835 9021 3875 PMC9254464__F7 Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest 2475 7001 7879 PMC9255238__F1 An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer 355 948 3479 3480 2475 5728 3082 6714 2146 PMC9256444__F2 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting 6387 3371 3082 4314 4318 4313 7039 7422 9242 PMC9256444__F6 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting 4087 4088 4089 5728 2475 PMC9257083__F6 Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis 1611 10392 7124 PMC9258714__F6 SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis 6713 5111 595 1017 PMC9264363__F7 Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex 6449 57506 7917 8266 57130 PMC9265893__F3 Ferroptosis and Its Role in Chronic Diseases 2475 79071 2182 2879 619501 55240 PMC9266365__F8 Metformin Attenuates UVA-Induced Skin Photoaging by Suppressing Mitophagy and the PI3K/AKT/mTOR Pathway 65018 472 2475 PMC9268386__F2 Estrogen-Related Receptor A: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis 4322 10010 26054 54476 3458 6772 4609 PMC9268899__F1 Astrocytes in Neurodegeneration: Inspiration From Genetics 348 4318 2475 5071 6622 120892 PMC9270398__F9 Working model of TRIM24 in regulation of P-bodies in response to insulin 8805 3667 27161 23644 PMC9270875__F2 Metabolic Requirements for Pathogen Response 3939 3945 2539 2744 PMC9272757__F2 Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway 1977 64223 2475 64798 27250 PMC9274608__F2 Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers 283460 1499 5090 5013 PMC9279723__F1 Autophagy in Bone Remodeling: A Regulator of Oxidative Stress 7942 2309 2475 PMC9280276__F3 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer 121549 10162 23657 2879 PMC9280276__F4 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer 2879 940 6520 975 5627 7301 2621 4280 6772 3659 PMC9280276__F5 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer 2170 2173 6935 7291 6615 23657 6520 7037 92140 2879 2182 4771 PMC9286619__F1 The androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments 1956 367 6714 847 PMC9289362__F1 Factors Affecting the Expression of Recombinant Protein and Improvement Strategies in Chinese Hamster Ovary Cells 581 5066 100423038 PMC9293663__F7 Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling 4314 3553 3627 PMC9294245__F4 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells 4170 596 581 4193 PMC9294638__F2 Emerging Role of Non-Coding RNAs in Senescence 1499 324 283120 4040 4041 595 PMC9298327__F1 Expression, prognostic significance and therapeutic implications of PD‐L1 in gliomas 940 3902 5728 7535 941 942 324 PMC9298969__F1 Glucagon-Like Peptide-1 Receptor Agonists as Potential Myelination-Inducible and Anti-Demyelinating Remedies 2932 387 2308 2475 PMC9298971__F1 Overnutrition Induced Cognitive Impairment: Insulin Resistance, Gut-Brain Axis, and Neuroinflammation 3479 5443 181 PMC9302595__F2 Extracellular signals activate the intracellular signaling pathway mTOR 5764 84632 7249 2263 7248 5524 9211 3398 PMC9306048__F7 Forkhead Box S1 mediates epithelial-mesenchymal transition through the Wnt/Beta-catenin signaling pathway to regulate colorectal cancer progression 1499 6932 324 4316 999 1000 PMC9308790__F8 Molecular mechanisms underlying TRIM25-regulated DOX-induced cardiotoxicity 22926 7494 7706 PMC9310656__F2 Gut Microbiota: A Novel Player in Autoimmune Hepatitis 114548 3661 7099 4615 51135 54106 196 1543 151306 PMC9313047__F3 Pathological Features and Neuroinflammatory Mechanisms of SARS-CoV-2 in the Brain and Potential Therapeutic Approaches 7098 59272 6347 6351 7054 PMC9314177__F6 Cebpb Regulates Skeletal Stem Cell Osteogenic Differentiation and Fracture Healing via the WNT/Beta-Catenin Pathway 7008 1051 121340 860 PMC9314411__F8 Proposed model of the UVB-triggered biochemical pathways in human dermal fibroblasts 596 581 1950 472 PMC9314556__F1 Mitochondrial Epigenetics Regulating Inflammation in Cancer and Aging 581 115004 29110 3661 PMC9315629__F5 Circular RNA in Brain Tumor Development 246751 83737 10000 257218 55294 7422 1038 51741 960 PMC9317121__F10 BMP Signaling Pathway in Dentin Development and Diseases 650 653 651 4091 4092 652 4488 860 4090 4086 4089 5083 4487 1834 1758 PMC9317256__F1 Biosynthesis of Non-Endogenous Apocarotenoids in Transgenic Nicotiana glauca 717 727 718 PMC9317563__F1 Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms 9839 55502 54790 2146 546 6689 860 4775 4609 10320 2475 6925 23451 7157 6427 5925 8233 472 3665 53335 2120 4893 3845 3394 3663 4261 54106 51284 3661 7124 29760 941 958 6850 6714 114548 9447 558 7097 7099 4615 940 1493 7098 11201 596 2752 29851 695 7189 7187 201633 939 961 140885 PMC9317725__F1 Microbial Poly-Gamma-Glutamic Acid (Gamma-PGA) as an Effective Tooth Enamel Protectant 729 718 727 367 PMC9319477__F6 Cyclic Hypoxia Induces Transcriptomic Changes in Mast Cells Leading to a Hyperresponsive Phenotype after FcERI Cross-Linking 2207 5321 5608 PMC9319897__F5 Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers 6347 3569 1401 3606 3553 2717 4015 3627 3574 6361 PMC9319949__F11 Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy 1803 7099 3146 114548 2475 8878 596 581 PMC9321618__F3 Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms 847 1728 9817 PMC9323154__F1 Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential 572 637 581 355 8772 PMC9325158__F1 Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy 115004 7189 5971 3661 920 3454 3455 7054 10379 PMC9329168__F1 Improving Treatment Options for Primary Hyperoxaluria 9380 183 1610 3939 PMC9329358__F1 Molecular mechanism of pyroptosis 79792 3146 56169 7124 1687 3001 3002 55876 PMC9329401__F7 High protein diet in the induction of sIgA response 5284 7099 56477 PMC9332480__F4 Multifunctional Role of S100 Protein Family in the Immune System: An Update 6347 6351 6348 4353 PMC9338328__F6 Radiotherapy combined with immunotherapy: the dawn of cancer treatment 115004 29110 3661 6774 6347 729230 PMC9338646__F1 Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment 23410 23409 23408 10135 126669 23475 93100 65220 924 952 51547 23411 51548 4318 PMC9339493__F5 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) 574452 101927667 439990 84981 7503 6774 441951 PMC9339597__F2 Complement System in Metabolic-Associated Kidney Diseases 720 717 727 729 966 PMC9339684__F3 Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis 2475 115004 2626 6774 6772 PMC9340488__F2 Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions 7096 7097 10333 4615 7189 7099 7187 3661 3665 7113 7098 51135 54106 51284 59272 PMC9343600__F11 Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice 650 860 3569 1803 2695 100187907 3717 6774 PMC9350078__F3 NK cell dysfunction is linked with disease severity in SARS‐CoV‐2 patients 3606 7124 947 PMC9350412__F7 SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy 115004 3661 29110 7054 59272 PMC9358977__F2 Immune-mediated inflammatory diseases with chronic excess of serum interleukin-18 114548 331 58484 998 9948 PMC9361020__F3 Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease 3553 7189 22926 PMC9361070__F1 Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer 2879 6520 2746 2182 10162 4015 PMC9361070__F2 Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer 55240 8031 3315 3162 9817 PMC9366230__F8 Cell membrane coated-nanoparticles for cancer immunotherapy 8205 3663 8544 PMC9367238__F2 Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer 5728 4193 4194 56950 898 5925 7867 PMC9367932__F1 Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions 7124 729230 1235 6347 6364 50489 PMC9368934__F2 Stem Cell-Based Therapies for Inflammatory Bowel Disease 9817 4094 4353 847 PMC9371824__F12 Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury 7099 4118 51135 7189 84890 3929 929 PMC9372463__F2 Influence of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction 23411 3479 23410 PMC9374328__F1 c-Met: A Promising Therapeutic Target in Bladder Cancer 6714 717 64750 4092 3082 4286 1385 PMC9375293__F2 Targeting purine metabolism in ovarian cancer 8205 920 6774 PMC9375713__F2 NLRP12 in Innate Immunity and Inflammation 7099 4615 3654 7189 91662 7124 7187 3661 7098 7706 51284 57506 834 3553 PMC9376771__F1 Hepatocellular carcinoma and microbiota: Implications for clinical management and treatment 7099 4615 3654 51135 7189 23118 257397 PMC9376779__F4 Transcriptome changes in stages of non-alcoholic fatty liver disease 2100 2353 252995 117283 1409 10135 1316 6777 4609 23089 51655 PMC9377404__F8 Vitamin B6 Metabolic Pathway is Involved in the Pathogenesis of Liver Diseases via Multi-Omics Analysis 7358 7360 100187761 316 55163 57016 29968 2990 3606 6652 9942 10327 51181 51084 1881 1610 717 5447 PMC9380290__F1 Mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets 1499 4041 324 5728 2475 472 596 581 PMC9381384__F1 Clinical, phenotypic and genetic landscape of case reports with genetically proven inherited disorders of vitamin B12 metabolism: A meta-analysis 4036 55788 5826 25974 27249 4548 166785 868 4594 PMC9381515__F3 Mechanism of necroptosis leads to airflow limitation in COPD 3146 11035 197259 PMC9384336__F5 Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method 54106 4615 51135 7189 51311 7098 51284 3665 29110 7187 3661 7099 7097 7096 5879 PMC9386306__F10 Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression 7291 9839 999 PMC9389016__F7 Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder 3098 1610 2548 4129 4128 5837 276 PMC9389535__F2 Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota 85480 3458 3606 7124 941 920 PMC9394213__F3 Roles and functions of SARS-CoV-2 proteins in host immune evasion 3661 57506 100187761 10379 6772 6773 4928 PMC9394702__F3 miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma 1499 1105 999 PMC9395613__F1 Advances in cell death mechanisms involved in viral myocarditis 355 8772 114548 1356 27250 2475 581 PMC9397497__F6 Electrical stimulated GLUT4 signalling attenuates critical illness‐associated muscle wasting 2475 9882 2309 PMC9404585__F1 Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2 7305 6714 2475 6850 PMC9404922__F1 Expression of Key Factors of the Hippo Signaling Pathway in Yak (Bos grunniens) Mammary Gland 4485 9113 7003 26524 PMC9405713__F9 HPV16E7 Affibody as a Novel Potential Therapeutic Agent for Treating Cervical Cancer Is Likely Internalized through Dynamin and Caveolin-1 Dependent Endocytosis 1869 595 1019 PMC9405826__F7 ALCAM: A Novel Surface Marker on EpCAMlow Circulating Tumor Cells 1499 1950 4790 596 4313 214 PMC9408960__F1 Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases 1896 128178 23118 7189 5971 10913 10342 4050 3604 PMC9409119__F1 Emerging Key Role of the mGluR1-PKCG Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint 85397 3632 6908 7222 9262 PMC9409325__F8 Tumor Necrosis Factor-Alpha-Induced C-C Motif Chemokine Ligand 20 Expression through TNF Receptor 1-Dependent Activation of EGFR/p38 MAPK and JNK1/2/FoxO1 or the NFKB Pathway in Human Cardiac Fibroblasts 1956 7124 6364 PMC9412694__F4 Impact of Epitranscriptomics on Antiviral Innate Immunity 8780 3661 57506 5728 3665 2152 PMC9413544__F1 Neuroprotective Natural Products’ Regulatory Effects on Depression via Gut–Brain Axis Targeting Tryptophan 8564 15 65057 PMC9414791__F12 Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice 2638 3416 7124 3603 581 1103 PMC9424811__F3 RING finger protein family in health and disease 84282 79845 54941 63891 55905 54476 6048 27246 79589 26994 7187 29110 3661 57506 127544 80196 8737 55298 PMC9427794__F7 Schematic model of GASP1 promoting malignant phenotypes of breast cancer cells and decreasing their response to paclitaxel by forming a positive feedback loop with the IGF1/IGF1R pathway 3479 3480 4193 PMC9429646__F1 Lipid rafts in cancer stem cell: a target to eradicate cancer 1499 2932 960 324 100133941 6608 51684 7852 PMC9433876__F3 Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response 4485 9113 26524 PMC9433910__F3 Progress in preclinical studies of macrophage autophagy in the regulation of ALI/ARDS 5599 5594 2475 114548 PMC9437486__F6 Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway 9817 23657 2879 PMC9437626__F2 Therapeutic targets by traditional Chinese medicine for ischemia-reperfusion injury induced apoptosis on cardiovascular and cerebrovascular diseases 581 637 717 8717 7124 PMC9437842__F4 GRPR neural and signalling pathways 4852 2925 2922 4886 83737 PMC9440249__F10 E-375i elicited anti-PCa effects 5775 6774 367 596 142 4316 4318 PMC9440251__F6 Nintedanib induces a senolytic effect in senescent HDFs via JAK2/STAT3 pathway 1017 3717 6774 PMC9442994__F9 MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/Beta-catenin signaling pathway 998 9645 999 1499 PMC9446768__F1 Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases 7350 7054 1734 1149 6955 PMC9450187__F1 Molecular Mechanisms of New Bone Formation in Axial Spondyloarthritis 4040 4041 1499 3351 7166 PMC9450808__F2 Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids (Review) 1581 80270 1582 6718 1109 1593 9420 5825 4280 570 PMC9451491__F4 Yuan-Zhi decoction in the treatment of Alzheimer’s disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and experimental evaluation 4137 5979 3579 1241 5724 4311 2904 7415 5582 6622 7422 3737 3606 3565 2743 351 4353 1636 2932 PMC9453003__F1 P38 MAPK Signalling in Testis Development and Male Fertility 4216 6736 5608 54361 284654 6662 56603 2254 339345 PMC9453300__F3 Emerging role of different DNA methyltransferases in the pathogenesis of cancer 5266 572 5728 4193 PMC9453641__F3 Gamble between oncolytic virus therapy and IFN 3661 6774 5132 7097 PMC9453844__F6 Identification of potential miRNA-mRNA regulatory network and the key miRNAs in intramuscular and subcutaneous adipose 51384 7482 4007 7480 84870 6770 7474 8061 5532 5467 PMC9456504__F1 Antimicrobial Peptides in Gynecological Cancers 7097 10333 1594 7421 1000 6590 595 PMC9457687__F5 Single cell states of the NFKB signaling pathway 7314 3553 3576 3569 717 PMC9460961__F2 Combination strategies to optimize the efficacy of chimeric antigen receptor T cell therapy in haematological malignancies 942 941 5817 201633 613 695 3702 652070 940 917 2475 8205 PMC9461676__F3 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies 2191 3570 90865 80310 7424 7422 PMC9461676__F4 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies 3904 920 50943 25801 7054 355 PMC9461676__F5 Tumor Microenvironment and its Implications for Antitumor Immunity in Cholangiocarcinoma: Future Perspectives for Novel Therapies 2919 100506696 6374 6774 5008 PMC9467755__F2 Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future 3146 114548 3569 PMC9469619__F1 Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway 100302126 2735 374654 51684 2737 2736 6657 6608 79923 117581 6469 25940 PMC9470863__F1 Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth 4615 941 942 920 PMC9471148__F2 An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors 2475 5156 6773 6772 6774 4763 673 3815 PMC9472457__F2 Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19 7113 11277 1777 115004 100187761 57506 7099 4615 51311 51284 7098 3661 29110 3665 64207 3452 64127 199713 114548 3458 10379 PMC9475269__F2 Amino acid metabolism in skeletal cells 9056 81539 468 6507 2744 6510 5741 435 54407 PMC9475465__F3 Immunosuppression in tumor immune microenvironment and its optimization from CAR-T cell therapy 100187761 3579 3577 PMC9476729__F2 Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NFKB pathway activation 7038 3630 5465 PMC9479087__F2 Polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment 6723 6611 54498 196743 6520 PMC9479192__F1 Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies 2932 324 1499 PMC9483046__F1 Research Progress on Exosomes in Osteonecrosis of the Femoral Head 860 9242 947 PMC9483726__F3 Comprehensive elaboration of circular RNA in multiple myeloma 693195 10000 23476 22863 5596 693223 1021 6502 3065 9429 PMC9485270__F5 Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance 1499 1029 673 4739 4609 4893 5728 7015 5163 PMC9485670__F2 Advances in the research of the mechanism of secondary resistance to imatinib in gastrointestinal stromal tumors 137196 3480 4193 PMC9489416__F9 MCU Inhibitor Ruthenium Red Alleviates the Osteoclastogenesis and Ovariectomized Osteoporosis via Suppressing RANKL-Induced ROS Production and NFATc1 Activation through P38 MAPK Signaling Pathway 7189 1513 54 245972 90550 4772 860 PMC9495176__F6 Bioinformatics and Genomic Analyses of the Suitability of Eight Riboswitches for Antibacterial Drug Targets 26227 2653 10249 6470 2731 27232 1757 29958 PMC9495847__F10 Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NFKB Signaling Pathways 4615 7099 9817 581 PMC9496180__F8 Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor 6774 4018 6010 1277 4088 PMC9497241__F1 From Molecular Mechanisms to Therapeutics: Understanding MicroRNA-21 in Cancer 54487 29102 5901 27161 100187761 PMC9502459__F1 Do or Die: HPV E5, E6 and E7 in Cell Death Evasion 7186 8717 355 637 581 572 PMC9502517__F2 Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach 355 8772 841 836 PMC9505944__F2 Controversial Role of LPS in Platelet Activation In Vitro 4615 7187 3661 114609 51135 3656 3654 7189 7099 929 PMC9506679__F2 Emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment 10013 6737 51191 3661 PMC9508558__F8 Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma 8824 355 4609 PMC9510596__F1 Tryptophan metabolites in depression: Modulation by gut microbiota 15 438 8564 8942 PMC9511018__F2 Non-cytotoxic functions of CD8 T cells: “repentance of a serial killer” 355 4283 3627 3458 6348 PMC9512240__F4 Radiation-induced Cell Death and Its Mechanisms 114548 2879 23657 6520 PMC9515687__F3 Inflammasome NLPR3 in the Development and Therapy of Periodontitis 114548 3553 25827 79184 79792 PMC9518217__F1 Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments 7096 10333 51135 7189 3656 7097 7099 929 4615 7098 114609 4118 54106 51284 66008 PMC9522619__F7 Properties of flavonoids in the treatment of bladder cancer (Review) 4318 960 79923 4193 216 2261 7124 23411 2475 29959 5728 PMC9523578__F1 Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity 578 2113 2114 PMC9530352__F1 Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases 4615 3663 3665 PMC9534854__F9 BNC1-Merlin-Hippo-YAP signaling -Ferroptosis axis 646 4771 9113 26524 2879 2182 7012 PMC9534897__F4 Extracranial arteriovenous malformations demonstrate dysregulated TGFB/BMP signaling and increased circulating TGFB1 4086 4091 3280 23462 23493 182 5155 2335 4088 4092 PMC9535304__F4 Molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NFKB pathway under oxidative stress 9290 5879 7189 9817 8841 7975 PMC9537379__F3 B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions 940 10750 941 942 57379 5450 3667 2638 PMC9537379__F5 B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions 3595 10148 6774 6772 10750 941 940 PMC9545958__F8 LncRNA AK018453 regulates TRAP1/Smad signaling in IL‐17‐activated astrocytes: A potential role in EAE pathogenesis 10131 4089 4087 7124 PMC9547461__F2 Emerging role of pyroptosis in pediatric cancers: from mechanism to therapy 7124 8717 7186 7188 23118 8737 11035 9825 197259 1687 81030 79792 58484 22861 8772 841 637 581 317 PMC9547461__F7 Emerging role of pyroptosis in pediatric cancers: from mechanism to therapy 3146 3553 3001 3002 1687 79792 55876 PMC9548363__F8 Juniperus communis extract ameliorates lipopolysaccharide‐induced acute kidney injury through the adenosine monophosphate–activated protein kinase pathway 7099 6347 3553 PMC9548442__F1 Lighting the way to host-directed immunotherapeutics 558 2621 7187 29110 3661 3665 3456 3454 6772 3455 3716 10379 6773 7297 PMC9550190__F2 Conducive target range of breast cancer: Hypoxic tumor microenvironment 643 2256 6774 1956 50943 6387 7852 PMC9552419__F9 SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain 847 7442 6347 6348 6351 6354 6356 PMC9553029__F3 NMDARs mediate peripheral and central sensitization contributing to chronic orofacial pain 7038 24145 3240 7442 PMC9553898__F8 Possible scheme depicting the role of mTORC1 signaling in estrogen-induced epithelial cell proliferation and differentiation in mouse vagina 57521 2069 10413 PMC9554302__F2 Advances in RIPK1 kinase inhibitors 8717 7186 8772 197259 1540 PMC9554952__F3 Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer 7124 355 8717 8772 637 581 4170 PMC9558762__F3 Physiological and pathological roles of Hic-5 in several organs (Review) 4092 4087 4088 4089 1499 7099 8772 4015 367 6925 387 PMC9561951__F2 Cellular autophagy, the compelling roles in hearing function and dysfunction 2290 665 7942 79065 2932 PMC9562258__F1 BRAF Inhibitors in Non-Small Cell Lung Cancer 2885 673 3845 369 PMC9562907__F1 Complement in nonalcoholic fatty liver disease 716 715 717 727 PMC9563036__F4 Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health 5159 596 581 627 4803 PMC9563233__F1 ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway 2002 5080 3014 472 11200 8205 PMC9569475__F5 Hsp90 as a Myokine: Its Association with Systemic Inflammation after Exercise Interventions in Patients with Myositis and Healthy Subjects 6774 6772 3055 PMC9569594__F10 Novel Thieno [2,3-b]pyridine Anticancer Compound Lowers Cancer Stem Cell Fraction Inducing Shift of Lipid to Glucose Metabolism 51083 2583 6483 PMC9569901__F1 Genome-Wide Identification, Characterization and Expression Analysis of Toll-like Receptors in Marbled Rockfish (Sebastiscus marmoratus) 7939 7097 929 114609 4280 1513 54106 7098 4615 7187 23118 100187907 3661 7124 941 PMC9570382__F2 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer 693207 3845 10746 5090 1969 574461 PMC9570382__F4 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer 1956 1021 1019 PMC9573519__F2 Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets 8772 355 581 7351 PMC9576687__F3 Premature senescence induced by ischemia/reperfusion injury 54210 3569 1021 1019 PMC9578007__F5 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis 7143 79026 7124 6414 26998 1956 3952 345275 5919 9370 56729 252995 627 1896 6678 10135 3600 3569 284207 10468 2660 PMC9581396__F1 Editorial: Osteoporosis, sarcopenia and muscle-bone crosstalk in COPD 260431 1431 4088 2660 4772 6774 3717 PMC9582647__F1 Plasma membrane and brain dysfunction of the old: Do we age from our membranes? 3553 3554 2475 3667 9021 2932 7099 4204 PMC9583737__F7 Wnt-mediated fibrosis in CD 324 4087 4088 PMC9587781__F1 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease 718 717 727 728 729 730 735 PMC9587781__F3 Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease 3553 114548 7374 PMC9588473__F5 High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach 27122 1499 6422 27123 22943 11197 1855 8312 2932 6932 7070 7042 920 PMC9589179__F7 Mining of transcriptome identifies CD109 and LRP12 as possible biomarkers and deregulation mechanism of T cell receptor pathway in Acute Myeloid Leukemia 941 942 2267 940 3902 324 201633 10666 10225 151888 634 PMC9590378__F1 Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance 627 2668 56616 65018 3569 PMC9599067__F3 Clusterin Transporter in the Pathogenesis of Alzheimer’s Disease at the Blood–Brain Barrier Interface: A Systematic Review 4040 4041 1499 55366 8549 59352 54894 84133 324 PMC9599207__F2 Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside 26524 10413 6935 PMC9599896__F2 Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma 7593 2932 1000 999 8313 1499 1956 PMC9600220__F2 Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions 6774 2475 5300 3717 2625 90865 6761 4615 3654 7189 59307 51135 PMC9600385__F2 Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance 23066 5597 5595 PMC9601273__F2 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer 92140 7422 2919 2920 10672 6294 PMC9604018__F7 Pharmacological and Therapeutic Applications of Esculetin 2308 2194 84649 PMC9604720__F1 Brain-Derived Neurotrophic Factor in Immune-Related Diseases: A Narrative Review 627 5045 5340 4318 4313 PMC9605520__F3 Preclinical and Clinical Research Models of Prostate Cancer: A Brief Overview 1586 3292 3294 3284 1583 6715 3293 5959 1646 PMC9605584__F1 DPP3: From biomarker to therapeutic target of cardiovascular diseases 10072 59272 1728 PMC9607849__F1 Development of a Chiral Supercritical Fluid Chromatography–Tandem Mass Spectrometry and Reversed-Phase Liquid Chromatography–Tandem Mass Spectrometry Platform for the Quantitative Metabolic Profiling of Octadecanoid Oxylipins 4015 59344 2717 PMC9607901__F3 Recent advances in the diagnostic and therapeutic roles of microRNAs in colorectal cancer progression and metastasis 324 2932 1499 4092 4087 4089 4088 5728 2475 3091 1956 7124 8717 7186 2002 4170 894 595 3717 6774 PMC9610147__F1 Innate immune responses by rabies virus 3660 3665 3661 29110 5371 7297 10379 6773 6772 3659 PMC9612213__F3 Molecular Mechanisms of Inflammasome in Ischemic Stroke Pathogenesis 114548 7099 4615 8772 8737 PMC9616080__F2 Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response 3716 6774 85480 6772 207 PMC9616825__F8 Schematic illustrating the working model of diabetes-induced bone marrow dysfunction 7040 121340 5468 6387 PMC9682156__F1 Autophagy and the primary cilium in cell metabolism: What’s upstream? 4087 4088 201163 4160 2475 PMC9751411__F2 Interferon and interferon-stimulated genes in HBV treatment 3454 3455 6772 6773 10379 920 PMC9913267__F4 Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis 4056 2687 1800 64174 PMC9962262__F3 Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures 406 9575 2932 6095 6096 2475 PMC9999652__F5 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 1786 2475 84890 5873 8205 PMC10030845__F2 Inflammasome and pyroptosis in autoimmune liver diseases 114548 3553 79792 PMC10036653__F8 ER stress induces upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival 22926 57057 650 PMC10037406__F1 CGAS-STING signaling pathway 115004 3661 29110 PMC1172066__F8 Model depicting how inner ear polarity is generated in response to extracellular signals 5076 6469 2637 PMC1173149__F10 TAp63Alpha-induced apoptosis 596 581 317 PMC1183420__F1 Simplified 13-hydroxylation pathway of GA biosynthesis in vegetative tissue of pea 340451 6588 100188864 PMC1322299__F1 Tweaking Microtubules to Treat Scleroderma 4087 4088 4089 PMC1323499__F1 New Approaches to Vaccine Adjuvants: Inhibiting the Inhibitor 7099 7098 51284 4615 3661 PMC138699__F1 Simplified diagram of the canonical Wnt/Beta-catenin signaling pathway 324 2932 1499 PMC1389768__F1 The Challenge of Characterizing Operations in the Mechanisms Underlying Behavior 717 729 727 PMC140043__F8 RelB is required for Peyer’s patch development: differential regulation of p52–RelB by lymphotoxin and TNF 7124 4050 4049 4055 5971 5970 PMC1413672__F6 Activation of PI3K signaling by PV 5728 3611 2475 PMC1440308__F6 Alternative Th network 3566 6778 6772 2625 6775 PMC1479345__F3 Pathway analysis 7528 3727 3725 1409 9455 3315 387 1729 7040 5699 7124 3732 2194 376497 3558 6004 1843 1029 PMC1479345__F7 Pathway analysis 3920 1622 4609 5430 6919 PMC1480599__F7 Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response 3458 3459 3460 3716 7297 3717 6773 10379 3665 3661 PMC1481658__F11 Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity 5728 6774 5443 PMC155355__F7 Model outlining the roles of GAI/RGA-like GA-signaling components in the plant life cycle 5863 57139 2243 PMC156758__F1 NEW EMBO MEMBER’S REVIEW 3565 7186 3558 PMC1569532__F1 Different types of regulatory T cells 920 83737 50943 940 PMC1636614__F8 Schema of Ang II-induced NFAT activation in cardiac myocytes 7222 729 342538 PMC171388__F7 Model of Cripto’s inhibition of Act B signaling through the Smad2 pathway 4838 6997 4087 PMC1716201__F1 Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 572 90427 637 638 8739 4170 596 581 PMC1754372__F2 Th1- and Th2-like lymphocytes, and the key regulatory cytokines and their interactions in SS 3383 3553 3569 3458 3586 324 PMC1767116__F3 Mitochondrial death signalling pathways 572 637 56616 PMC1782192__F2 Direct and indirect activation of human natural killer (NK) cells 3137 352964 7098 51284 PMC1783691__F1 Differential Roles of Costimulatory Signaling Pathways in Type 1 Diabetes Mellitus 940 958 29851 324 PMC1832185__F2 Dose-dependent entry routes for the EGFR 1950 2060 1956 PMC1859939__F5 Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction 2932 4149 4609 PMC1860037__F1 Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies? 9021 6774 2885 8651 PMC1860592__F2 Biologic therapies: what and when? 920 1493 940 941 PMC1869627__F2 Pathway diagram developed using the Ingenuity Pathways Analysis and Knowledge Base in which all genes changed by more than 1.5 fold were queried 79026 6277 6285 2670 4478 9508 5962 825 1410 3371 831 824 8500 7273 2246 6279 4929 PMC1884140__F11 Schematic representation of the differentially expressed genes and how they are induced upon injection by (A) pristane or (B) phytol 3458 4600 8638 4938 3437 3665 4321 PMC1924866__F5 Striped view of multiple time-point comparisons 1906 7124 5729 1909 5734 5737 5739 7132 1910 5731 5732 5733 5321 301 307 302 306 308 309 5742 653145 5743 6916 5730 5740 3290 3248 1583 3291 PMC1964754__F6 Furin in development, homeostasis and disease 10913 5045 4313 PMC199181__F3 The NFKB pathway by viruses 7124 8717 7186 PMC1993906__F13 The G12/13 signaling pathway 695 7006 100124696 PMC1995599__F2 MOLECULAR AND CELLULAR MECHANISMS OF THE ANABOLIC EFFECT OF INTERMITTENT PTH 5741 572 57154 860 PMC2002564__F1 Arterial–venous specification in the developing embryo 6469 2304 2050 PMC2039930__F7 Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction 2932 4149 4609 PMC2040031__F1 INTERLINKING INTERLEUKIN-7 3716 3718 572 993 PMC2045534__F6 Schematic model of the role played by GADD34 and the mTOR pathway in the suppression of viral replication 7249 7248 2475 PMC2075101__F1 5-HT2A receptor agonists cause activation of GAq/11 proteins which in turn activate the second messenger enzyme PLC 3717 6000 6774 2353 3725 PMC2077853__F9 Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation 2668 5979 4067 6714 PMC208733__F1 Regulation of the Foxa and Foxo transcription factors through PI3-kinase signaling 3170 2308 4303 5225 3169 3171 PMC209288__F1 The biosynthetic pathway for the fibrillar collagens expressed in skin, identifying steps that are affected in different forms of EDS 107966124 1277 1278 1281 PMC2093951__F9 NOVEL VIP SIGNALING PATHWAY IN T CELLS cAMP→ Protein Tyrosine Phosphatase (SHP-2?)→JAK2/STAT4→Th1 differentiation 7432 3595 3594 7297 PMC209413__F1 The TGF-&bgr;/Smad pathway and its interrelationship with mediators of inflammatory signals 4087 4088 64127 3716 6772 4092 4089 PMC209477__F2 gp130 cytokine family pathways on anterior pituitary cells 1270 5008 3976 3929 929 PMC2100434__F2 Growth hormone-mediated JAK/STAT signal transduction 3717 8835 2690 PMC2128044__F12 Hierarchical representation of the JAK-STAT pathway with SOCS1 subsystem as a coordinator 8651 6772 3458 PMC2134905__F2 The p53 pathway and IGFBP3 581 3486 3479 PMC2149843__F1 A pro-adhesive PPARGamma-mediated chemokine receptor switch, CCR2→CX3CR1, in atherosclerosis 1524 729230 6376 PMC2173906__F7 Hypothetical scheme of the mechanism by which Dkk1 promotes osteolytic lesions in vivo 89780 1499 22943 650 PMC2175514__F9 Protein regulatory network indicates importance of ISGylation pathway in TLR7-mediated activation of pDC 7322 6478 7189 23118 5595 11274 4067 3661 6925 942 3716 2260 6772 PMC2212135__F6 Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2 3481 5618 3480 3482 7350 PMC2213208__F1 Activation of the vagus nerve leads to the release of acetylcholine (Ach) that binds to Alpha-7 nicotinic receptors (A7 nAChR) on cytokine producing cells 9021 7124 3146 6774 PMC2224766__F3 Proposed metabolic pathway for PSI-6130 1633 4397 978 1635 PMC2234385__F10 Model of TLR ligand activation of Kupffer cell–NK cell cross talk in co-culture 7098 4615 7097 7099 4049 PMC2258989__F6 Schematic presentation of the signaling pathway induced by HCV core protein for insulin resistance in human hepatocytes 3667 5266 2475 PMC2268054__F2 Mutations in the glycoprotein 130 (gp130) receptor lead to an imbalance in downstream signalling pathways 3716 9021 6772 3383 6774 PMC2276871__F1 Steroid receptor expression in postnatal day 5–10 developing prostates from oil-treated control rats (A) and neonatally estrogenized rats (B) 367 6256 5914 6257 PMC2277216__F1 Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history 54106 51284 51135 4615 3665 3663 3661 3394 PMC2287275__F2 Mesenchymal stem cell dysfunction in HGPS 3280 23493 23462 388585 390992 7088 666 9242 PMC2366099__F1 Folate and one-carbon metabolic pathway 6948 635 4548 4552 5444 875 4524 PMC2384123__F8 Possible model for CCL5-mediated mRNA translation in CD4+ T cells 6352 1234 2475 1977 595 1975 PMC2387183__F4 Autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling 3398 2354 3400 4091 3479 650 PMC2390552__F6 Analysis of Nodal signaling processes in ERK1MO and ERK2MO gene expression profiles 4838 4086 25805 93 64321 4087 4790 4089 1950 7321 3725 8928 2290 PMC2417189__F8 Inhibition of neurogenesis and axis duplication by mkrn2 via PI3K/Akt signaling pathway 23609 2932 1499 PMC2424295__F2 Feedback loops in NFKB signaling 7099 3661 4615 PMC2433332__F3 T-cell polarizing factors 940 920 27040 3717 3716 3718 7297 6774 PMC2453100__F7 The activated PI3K-AKT pathway and its downstream effectors that contribute to the tumorigenesis of TSHomas in TRBPV/PV mice 2932 2475 572 595 PMC2491722__F4 Gdnf signaling pathways within the mammalian spermatogonial stem cell niche 2668 5979 4067 6714 PMC2515336__F2 Representation of the two NFKB signaling pathways 958 4050 5971 5970 PMC2528845__F4 Opposing signals regulate sex determination in the bipotential gonad 2254 2263 6736 54361 6662 PMC2562925__F8 Schematic depicting the roles of p53 and wnt7b in proposed pathway for NGF-mediated neurite outgrowth in PC12 differentiation 7477 8326 4803 8324 PMC2564730__F3 Use of MIMO models to infer regulatory interactions in breast cancer cells 1950 1956 2475 3480 PMC2575728__F2 Following the cytokine signaling pathway to leukemogenesis: a chronology 2057 3559 3716 3718 3717 3932 5966 PMC2576563__F7 Tight regulation of MUC5AC mucin induction by pneumolysin via PAK4-JNK and MKP1 signaling pathways 7099 4615 7189 10298 4586 PMC2577435__F9 Signaling from LMP1 and TLR to IRF7 activation 54106 51284 4615 7186 7189 3665 PMC2581553__F7 The PpsB product and the proposed interaction between the PDIM and FAS-II pathways 95 355 3623 PMC2581770__F3 TNFR and LTBR signaling pathways for NFKB activation 4055 5970 5971 PMC2581785__F1 Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum 5091 3992 790 3990 PMC2593006__F3 Signalling pathways underlying neuronal survival and cognitive performance 2475 627 23237 PMC2605487__F2 Signalling pathways involved in the induction of astrocyte specification/differentiation 1270 3976 3977 4086 6774 4089 2670 PMC2613484__F7 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways 5971 4055 151888 PMC2633625__F2 Toll-like receptors in skin 7100 7099 7096 7097 10333 54106 51284 7098 4615 114609 51135 7189 3661 PMC2634254__F2 Embryonic liver development 2246 2247 652 3082 213 174 5629 3172 PMC2647628__F1 CATERPILLER (NLR) Family Members as Positive and Negative Regulators of Inflammatory Responses 4615 54472 3654 5971 5970 7852 6387 10563 PMC2650609__F6 Top network of upregulated genes in quadriceps muscles of COPD patients, compared with control subjects 50486 687 7351 2309 9123 217 2308 7431 2275 2934 9467 PMC2653092__F5 Basic Helix-Loop-Helix Factor Hand2 Regulates Autonomic Nervous System Development 8929 9464 401 2625 7054 1621 PMC2654418__F6 Crosstalk between the Androgen Receptor and Beta-Catenin in Castrate Resistant Prostate Cancer 2932 7525 4067 1499 367 56998 51176 6925 6929 4609 PMC2658783__F2 The erbB family and the IGF/IGF-1R system 3480 7039 3479 3481 PMC2659402__F3 Interleukin-31 acts through three signaling pathways: Jak/STAT pathway, PI3K/AKT pathway and MAPK pathway 6774 3716 3717 9180 2885 PMC2660752__F6 Metabolic origin of glyoxylate in M 718 727 717 PMC2662697__F6 Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88 Dependent and Independent Signaling and is Reciprocally Modulated by LXR Activation 7099 7097 929 948 19 4615 3661 PMC2666844__F6 Simplified schematic diagram of transforming growth factor-alpha/epidermal growth factor receptor signaling pathway (TGFA/EGFR) 7039 1956 2885 PMC2670967__F2 Schematic (simplified) representation of enzymatic and metabolite components of the liver methionine metabolic pathway, and the influence of ethanol consumption 4524 635 4397 27232 PMC2673236__F1 Schematic illustration of one-carbon metabolism pathway 4552 4548 635 4524 PMC2674225__F2 Repression of TGFB-RII and abrogated signaling through the Smad pathway 1950 3458 7046 3716 4087 4088 6772 387 4089 4092 PMC2677203__F7 Signaling via the TgfB type I receptor Alk5 in heart development 50808 4090 4087 387 4772 860 1499 PMC2677552__F3 PharmGKB pathway diagrams 3292 1555 1557 1576 1559 1588 1565 2100 PMC2678071__F1 Graphical representation of the gp130/JAK/STAT pathway 3976 3977 9021 5008 PMC2679127__F2 PRRs and their corresponding ligands 7098 10333 7096 4615 54472 7100 51284 7189 54106 64127 81793 PMC2679302__F2 Network contains downregulated genes and identified around NFKB gene 8567 3134 29108 6288 PMC2679364__F6 OVARIAN CANCER 673 3845 7157 PMC2680291__F1 Illustration of some of the key enzymes involved in the metabolism of methotrexate (MTX) 6573 9429 8836 2356 471 7298 1719 2271 4524 PMC2684021__F1 The fungal cell wall and downstream cellular responses following engagement of Dectin-1 and TLRs on antigen presenting cells (APC) 324 6850 64170 7124 3569 3586 3558 4615 PMC2684527__F2 Stochasticity in Protein Levels Drives Colinearity of Gene Order in Metabolic Operons of Escherichia coli 4151 4499 4504 84560 PMC2684977__F2 Biologic actions of isoprenoids 650 387 5879 PMC2692634__F1 THE ENZYMES OF THE 10-FORMYL-TETRAHYDROFOLATE SYNTHETIC PATHWAY ARE FOUND EXCLUSIVELY IN THE CYTOSOL OF THE TRYPANOSOMATID PARASITE LEISHMANIA MAJOR 2512 4522 10797 PMC2693232__F2 Unifying model of TGFB signaling in breast epithelium 960 100133941 7048 1000 7431 6678 858 7039 3479 PMC2699361__F1 The ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX 7186 581 572 PMC2700095__F10 Alternative kinetic model incorporating unknown transcription factor (TFx) activation by Eda/Edar signaling 2253 6469 5970 10913 1896 128178 7186 1956 7039 7189 1950 PMC2700213__F1 Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians 5443 7306 283652 8455 434 PMC2700405__F1 The canonical Wnt/Beta-catenin signaling pathway 4041 4040 8312 2932 324 1499 PMC2709272__F1 Wnt/Beta-catenin signaling in adipogenesis and metabolism 7480 6425 22943 2932 7124 81029 PMC2711321__F2 Wiring diagrams for a three-module decomposition of the intrinsic apoptotic pathway 596 581 331 735 718 PMC2711664__F1 Signal transduction mechanisms implicated in leptin action 2475 3717 6774 PMC2712786__F1 Pathways of extrinsic and intrinsic apoptosis, highlighting roles of Bcl-2 family members 572 90427 8739 638 637 PMC2713245__F1 Signal transduction through activin receptors 10220 4091 4092 4087 4088 1499 4089 PMC2713831__F5 Local Network Topology in Human Protein Interaction Data Predicts Functional Association 2331 11171 4054 2022 3725 1601 54778 7042 6498 5371 28996 7049 6497 7045 3623 3625 2661 3624 3626 3547 92 659 93 57154 64750 7046 8202 PMC2716793__F3 Spatial complexity and control of a bacterial cell cycle 5426 5339 64065 PMC2718282__F8 The role of Mal connecting PI3K to TLR2/6 10333 7096 7097 4118 4615 PMC2722510__F7 Proposed pathway involved in the regulation of the osteoblast F-actin cytoskeleton, based upon previous literature and the current experimental results 5741 387 2695 PMC2723786__F1 BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells 958 545 1111 3662 604 472 PMC2724778__F3 Hypothesis-driven two-factor common pathway model path diagram of the metabolic syndrome 717 1628 7038 PMC2724779__F1 Complexity of sphingolipid biosynthetic pathways 10715 253782 29956 204219 91012 79603 PMC2725943__F7 A model of mammalian Hh signaling 5727 6608 2737 2736 51684 8405 2735 PMC2727866__F1 EGFR-dependent MAPK activation 4018 1956 3480 1839 PMC2727867__F1 Representation of some zinc-induced apoptotic pathways 2147 717 2152 PMC2728746__F7 Proposed model for the mitogen-activated protein kinase kinase 4 (MEK4) regulation of human prostate cell motility and for its inhibition by genistein 4088 4086 9261 2022 PMC2729812__F1 Proposed pathway from pressure overload to LV hypertrophy and fibrosis 8038 1839 7039 PMC2730524__F3 Translating insights from the cancer genome into clinical practice 2064 1956 5728 4609 672 PMC2733082__F2 InterferonG signaling pathway and mutations in its components found in human uterine leiomyosarcoma 3716 3717 6772 3659 PMC2737901__F1 Putative biosynthetic pathway of PUFAs in Mortierella alpina 1S-4 1896 1690 2717 PMC2739091__F8 Schematics of the effect IL-1B on the alveolar capillary barrier 3553 387 7939 1003 1499 PMC2741634__F2 How location governs Toll like receptor signaling 7099 114609 4615 7189 PMC2742090__F4 Negative feedback loops in the SHH signaling pathway driven by SHH-binding proteins 6469 2619 91653 PMC2743935__F5 Calcium signalling and cell-fate choice in B cells 29850 54795 5978 PMC2745891__F6 Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mTOR activity and p27Kip1 localization 6469 6608 2932 7248 7249 2475 PMC2747760__F1 Leptin signaling: A key pathway in immune responses 3667 8660 2885 5728 6774 6772 PMC2752361__F3 MOLECULAR CONSTITUTION OF BREAST BUT NOT OTHER REPRODUCTIVE TISSUES IS RICH IN GROWTH PROMOTING MOLECULES 7991 7490 2254 8031 2690 11214 3479 10451 8837 1398 2354 3725 834 PMC2752847__F1 Type I interferon production by dendritic cells in host defense 7097 7096 51284 51135 57506 3661 5132 PMC2756763__F1 Aromatase: synthesis of estrogen in postmenopausal women and its inhibition by aromatase inhibitors 3292 1588 412 PMC2761108__F8 Roles of BMP signaling pathways during SNS development 4089 8929 2625 9464 429 1621 7054 PMC2766052__F8 The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation 1283 57506 29110 3661 3665 7187 PMC2769199__F8 Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice 7097 7099 4118 4615 7098 3661 PMC2771153__F9 Schematic presentation of a model of induction of beta cell apoptosis during viral infections 4938 6041 7098 3630 PMC2774076__F7 Current working model of the signaling pathway components (shaded areas) that are differentially regulated in C57 and CD-1 pup brain tissues and cultured NSCs under normoxic and hypoxic (Hx) conditions 3091 627 7852 6774 2475 PMC2777795__F2 Negative-feedback loop linking NAD+/SIRT1 with the Clock network 9575 406 10135 23411 PMC2778955__F10 Expression of an IKKG Splice Variant Determines IRF3 and Canonical NFKB Pathway Utilization in ssRNA Virus Infection 57506 5970 3661 PMC2779188__F1 Genes involved in the vitamin D pathway 5212 2638 1593 120227 7421 3586 940 9173 942 1591 PMC2781394__F8 HGF-mediated inhibition of gluconeogenesis in primary hepatocytes 3082 7391 3172 PMC2782488__F1 Cytokine signaling modules in inflammatory responses 50615 3575 149233 8651 9021 6774 6097 6095 50943 PMC2784899__F7 Model to account for responsiveness to cAMP level in activation but not inactivation of eumelanin synthesis 434 4157 23295 4286 4151 8455 PMC2786705__F8 Continued defect in IRF-3-deficient BMDCs 6773 6772 3661 PMC2787458__F9 Wnt3a stimulates Src docking to, activation by, and phosphorylation of Dvl2 89780 4041 4040 1856 6714 1499 PMC2790217__F17 Akt regulates growth by phosphorylating and inhibiting the TSC1-TSC2 complex in drosophila 5728 7249 2475 7248 PMC2796203__F2 Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer 7046 4087 4088 4092 4089 PMC2796930__F7 FGF-receptor signalling in the generation of hindbrain neural cell diversity 6662 10215 6469 PMC2805009__F1 Cross-talk between TCR and TGFB signaling networks 920 940 4087 4088 4092 3559 4089 3725 2353 50943 PMC2806747__F1 TLR4 signaling pathway can be activated via GAG fragments requiring CD44 and MyD88 or through LPS, which requires MyD88, LBP, and CD14 4615 960 3929 929 3553 PMC2807379__F6 Nephronophthisis: Disease Mechanisms of a Ciliopathy 5978 4041 4040 1499 324 2932 6010 PMC2809778__F2 Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, Parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis 65018 10131 27429 5428 5442 7019 PMC2810509__F3 BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN 4090 4086 4089 4087 4088 PMC2814179__F1 Therapeutic targeting of NOTCH1 signaling in T-ALL 4851 102 9794 PMC2814543__F4 Nutrient sensing and inflammation in metabolic diseases 9021 7124 6009 7249 2475 PMC2815188__F2 This presentation will focus on molecular mechanisms underlying transduction of BCR signals that enforce the antigen unresponsiveness of anergic B cells 7852 4067 1796 PMC2819159__F2 Obesity, Diet and Risk of Non-Hodgkin Lymphoma 4548 4524 1719 7298 PMC2820080__F5 Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE 3423 5327 5091 5919 9718 9796 5708 230 PMC2822937__F7 Downstream effectors of the ErbB receptor signalling pathway 2064 2066 2065 1956 2885 5728 PMC2824740__F5 Strain-induced quantitative mRNA-expression analysis of PDL cells related to MAP-kinase signalling and cell cycle, ECM and integrins, and growth factor pathways 2353 1031 4321 1839 7422 7424 2254 3589 7373 2247 2069 3606 650 PMC2826517__F1 The current understanding of PELP1 signaling pathway 1950 1956 27043 6714 367 6774 PMC2830970__F1 Schematics of the retroviral replication cycle 920 7852 1234 PMC2831232__F2 NKT cells in immune-mediated pregnancy loss 324 958 912 7099 54106 PMC2834195__F1 The circadian clock signaling pathway 406 9575 4862 PMC2834467__F2 Map showing relationship between genes positively correlated with plasma estradiol superimposed on Ingenuity map 51129 1952 5594 PMC2840045__F1 Innate immune responses in allotransplantation 3146 7097 7099 PMC2840670__F1 K-ras mutation governs the effects of inhibition of epidermal growth factor receptor (EGFR) on the Ras/Raf/Mek signaling pathway 1950 7039 1956 PMC2844056__F5 Ingenuity pathway analysis of genes up regulated in ER+ cell in response to AA shows that the ERK/MEK pathway was significantly associated with ER+ 23321 6774 572 PMC2851161__F1 The Notch signaling pathway 182 100188776 4855 4853 4851 4854 PMC2852602__F2 TLR/IL-1R signalling pathways 7097 7100 10333 7099 948 114609 4615 51284 7098 3656 54106 7187 7189 23118 51135 PMC2854301__F9 The Transcriptional Repressor REST/NRSF modulates Hedgehog Signaling 5978 2735 6469 PMC2855089__F2 NFKB Signaling Pathway 7124 8717 7189 4615 7099 PMC2856809__F3 Dual MAG receptor model 4099 84894 387 PMC2857099__F6 Proposed model for NFKB repression by TRAF3 in LTBR activation 4055 7187 7186 PMC2859139__F1 Immunoregulatory pathways 3458 7040 958 940 PMC2864407__F1 Description of the sex hormone metabolic pathway: genes involved in synthesis, bioactivation, metabolism, and inactivation of estrogen and other hormones 1583 367 6462 5241 1588 2100 1312 PMC2864712__F10 PAK4 regulates adhesion and migration via multiple signalling pathways 3082 10298 387 PMC2866107__F5 Current Status of Xenotransplantation and Prospects for Clinical Application 7450 324 7018 7035 PMC2869521__F3 Constitutive NFKB pathway activation in multiple myeloma 958 4055 7186 7187 1540 3550 5971 PMC2869556__F1 Metabolic folate pathway 4552 4548 4524 1719 PMC2871498__F9 Working model for S1P/SK/S1PR interplay during acrosomal exocytosis 124976 6497 5864 4363 PMC2872207__F1 TNF-induced NFKB pathway 7124 8717 595 PMC2872207__F3 Jak/STAT signaling pathway 3569 3976 3977 PMC2873439__F7 CXCR5 activate PI3K isoforms through GAlpha-Src-FAK pathway or via GB/G pathway leading to subsequent activation of ERK1/2 643 6714 5728 5266 1794 PMC2880865__F8 Revitalization of a diastemal bud 6469 2249 10253 2255 2248 PMC2881215__F1 Signaling in podocyte apoptosis 23607 2668 4851 PMC2888385__F6 Nodal-Smad2 signaling regulation of the BMP pluripotency pathway in mouse ES cells 4838 3423 2624 430 4092 2253 PMC2891338__F1 Endotoxin binding: Schematic overview of the LPS, LBP, CD14 and TLR-4 signal transduction pathway 3929 7099 4615 7189 3569 PMC2892843__F3 Dual MAG receptor model 4099 84894 387 PMC2893383__F2 Schematic of leptin signaling through STAT3 and PDE3B pathways in POMC and NT neurons in the hypothalamus 3717 3667 6774 5140 5443 7956 PMC2895370__F1 TLR4 signaling: The MyD88-dependent pathway through PDCD4 7099 4615 27250 PMC2896848__F2 Alternate and peripheral androgen synthesis pathways 1583 6770 412 1588 PMC2898418__F10 Schematic pathway of IL-8-mediated NAADP formation by CD38 in LAK cells 952 7226 3932 5330 2638 PMC2900152__F9 Proposed DAP12 signaling pathway in macrophages and osteoclasts 54209 10451 2885 6850 PMC2904169__F1 Hypoxia-inducible factor (HIF)-2 regulates erythropoietin (EPO) 2056 2624 100188864 PMC2904914__F1 Glial cell line-derived neurotrophic factor can signal through activation of Src kinases in SSCs 2668 5979 6714 4067 PMC2908764__F3 Molecular cues controlling the pathway choices at the Drosophila and vertebrate midline 6405 7869 3815 PMC2909379__F3 Hox Genes and Regional Patterning of the Vertebrate Body Plan 1045 3229 3218 PMC2910898__F1 During normoxia, HIF-1A is rapidly degraded by the ubiquitin-proteasome pathway 3091 405 2056 3939 PMC2913378__F3 Signaling pathways that mediate actomyosin-dependent disruption of the epithelial barrier in inflammation 6010 3553 7124 3458 PMC2915629__F4 Identification of RON-targeting genes 4010 10076 6929 2690 7316 5930 3207 5925 6530 7528 7159 4137 3725 2353 5590 3054 467 2261 4782 PMC2917906__F1 HIF-1A and HIF-2A have different functions in the cartilage 3549 860 5970 11096 PMC2921023__F7 Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin 6714 9846 2475 PMC2923715__F5 Wnt signaling pathways 27031 387 1499 PMC2923990__F7 Model for C 7097 7099 4615 6850 64170 8915 PMC2926258__F3 Schematic representation of the role of T cells in the mechanism by which intermittent PTH treatment stimulates bone formation 5741 7480 4038 4040 4041 PMC2933174__F6 Model depicting a novel mechanism by which cetuximab induces autophagy 1950 2475 596 PMC2937064__F3 CD28 signaling pathway in T cells is equivalent to the IGF-1 pathway in the whole organism 3480 940 2308 2309 PMC2937452__F1 Model of pyrimidine synthesis and salvage pathways in Toxoplasma gondii 1723 4975 139596 1283 PMC2942073__F1 Genetics of Psychosis in Alzheimer Disease: A Review 348 6653 1312 3084 1139 PMC2946515__F3 Mutant epidermal growth factor receptor, EGFRvIII, promotes cell survival and proliferation by preferential signaling through the phosphotidyinositol-3-kinase (PI3K) pathway 1950 2475 1956 PMC2949191__F6 Scheme outlining the novel role of Nogo-A in controlling neuronal survival in the ischemic brain 387 9475 5728 PMC2949777__F5 JAK/STAT pathway in infected EPCs 3716 6773 6772 10379 8554 2537 3430 PMC2950751__F9 Summary schematic illustrating the adaptations of select genes of the IGF-1/PI3K/Akt pathway involved in protein synthesis and degradation analyzed in the plantaris muscle 3667 4087 4088 2475 PMC2952492__F1 Regulation of neo-vascularization by SDF-1 2056 7173 7852 7422 PMC2952500__F1 Schematic diagram showing the results of ras activation by Grb2 2885 2627 5111 1950 5266 5900 PMC2955764__F1 Sonic hedgehog signaling pathway 6469 6608 64399 51684 27148 PMC2956608__F1 Inhibition of the type I interferon (IFN) pathway of Kaposi's sarcoma-associated herpesvirus (KSHV) 929 29110 3665 3664 PMC2964976__F8 CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs 948 2534 7001 PMC2970711__F7 Scheme of cross-talk interactions between TIM-3, Gal-9 and TLR4 signaling networks 7099 3553 6387 2919 PMC2975200__F9 MyD88-induced protein accumulation pathways through SQSTM1 and HDAC6 8878 1540 7189 10013 4615 PMC2975936__F1 Classical pathway of complement activation by antibody 718 720 721 PMC2975941__F2 Classical and non-canonical NFKB pathways 4055 958 613 7187 5971 PMC2984599__F1 TP53 levels determine whether CDKN1A will orchestrate irreversible senescence or quiescence 1026 2475 7157 PMC2989726__F5 CFTR Chloride Channel in the Apical Compartments: Spatiotemporal Coupling to its Interacting Partners 4018 1080 9351 PMC2992267__F8 A schematic model showing the proposed biosynthetic pathway for cutin 137964 1637 4018 4099 PMC2994991__F6 Reporter gene assay for HIF-1 activity 3091 405 4827 PMC2996094__F11 Proposed model of GF-mediated regulation of IGFBP-3 1950 1956 2475 3486 PMC2996236__F2 Autoinflammatory disease regulated by IL-1B (inflammasomopathies) and NFKB 3553 9051 114548 91662 199713 3603 PMC2996236__F5 Pathogenesis of the complement-mediated autoinflammatory disease atypical hemolytic uremic syndrome 727 3426 629 PMC2998095__F7 ID2 in clock resetting 9575 406 3398 PMC2999349__F3 Location of 2,4DNT impacted genes in the pathway association network 23236 5521 5789 5793 8608 PMC2999475__F8 Summary of metabolomic findings in Hnf1a-null mice 5053 6927 55117 PMC3000440__F1 Decorin effects as an antiproliferative (left panel) and proliferative (right panel) molecule 1956 1499 2475 PMC3003905__F5 Spontaneous-fusion-mediated cell reprograming is controlled by Beta-catenin levels in ESCs and not by their proliferation 717 89780 1499 PMC3004523__F2 Hypothetical roles for LAB-dependent positive signaling 3815 2534 6850 4067 2885 9846 3562 PMC3008616__F1 EGFR pathway and its main downstream effectors (top) 1956 3845 673 5728 PMC3013041__F5 Relationship between transcription factors and their regulatory factors 2932 2005 7018 2000 3726 3727 PMC3025359__F1 Mincle- and Dectin-1-mediated signalling in response to mycobacteria 6714 6850 4615 324 64170 7189 920 51135 PMC3032584__F1 NF-kappaB, a mediator for lung carcinogenesis and a target for lung cancer prevention and therapy 4050 8717 7186 5971 331 PMC3035679__F4 Human inherited and mouse experimental defects in the glycosphingolipids synthesis pathway that cause myelin disorders 7357 410 2581 6609 79152 PMC3039688__F7 Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts 3458 3454 3455 3459 3460 3717 3716 7297 6772 6773 10379 3456 8651 8835 9655 9021 9306 5777 5788 6774 5771 PMC3040753__F3 Gene Expression Profiling of Vasoregression in the Retina—Involvement of Microglial Cells 1356 1958 3958 2353 567 3126 3113 3115 12 5653 972 629 1520 5199 720 PMC3045483__F1 Interactions occuring in the ovarian mural granulosa cells (GC) and cumulus cells (CC) after the administration of hCG for ovulation induction 2638 214 374 685 1432 2069 5594 5595 5241 PMC3047755__F7 Proposed model for how Shh signaling pathway negatively regulates its mitogenic potential through Beta-arrestin 1 6469 6608 3667 PMC3048558__F7 Proposed mechanism of gene regulation in response to extracellular and intracellular dsRNA stimulation 7098 5971 5970 PMC3048839__F10 Schematic representation of IH-induced increase in adrenal medullary NPY by activation of reactive oxygen species (ROS) signaling pathway 1514 1363 5066 PMC3060380__F1 Myostatin activity and muscle growth 649 7092 7093 93 4087 4088 4089 PMC3060875__F5 Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses 942 941 27040 940 7535 3932 2534 2885 7409 PMC3061251__F1 Viral infection triggers the IFNB signal transduction pathway of the host innate immune system, activating the antiviral state 3454 3455 3716 7297 7098 6773 10010 7010 6772 1998 PMC3067813__F7 Model of proposed HEB, GATA3, and Notch1 interactions 4851 8328 2625 PMC3069932__F9 Proposed role of Nodal in human placental development and mechanism of Nodal-regulated trophoblast invasion 4838 4087 4088 4313 PMC3070952__F1 Essential features of the PERK signaling temporal delay circuit 83939 468 467 PMC3072659__F1 Pathways that modulate canonical Wnt signaling 1950 3082 4041 4040 2885 324 1499 607 PMC3077584__F6 The effects of apoA-I on TNFA mRNA stabilization in LPS-stimulated macrophages 335 7099 3717 6774 3553 PMC3081824__F3 Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing 6482 6483 6487 6484 8869 10402 6480 10020 10559 84620 55808 10610 81849 30815 6489 54187 10825 8128 51046 129807 7903 29906 338596 140838 4758 4759 55907 26503 PMC3081924__F10 Model for SENP2-mediated modulation of Mdm2 in regulating p53 4193 59343 5371 PMC3084988__F2 TLR structure and signaling 7097 7098 114609 3661 PMC3086210__F9 NH2-terminal Propeptide of Type I Procollagen Acts Intracellularly to Modulate Cell Function 7046 4088 4089 PMC3086918__F1 Mind the dbGAP: The Application of Data Mining to Identify Biological Mechanisms 8312 3075 2268 2022 7040 57147 2729 64102 PMC3089562__F7 Proposed model of how endocardial Jarid2 expression regulates myocardial development 3720 4851 3084 2064 2066 595 PMC3089878__F2 Cholesterol transport in the CNS 5091 3949 7436 107966124 PMC3095455__F1 Schematic representation of the apoptosis signaling pathway that indicates existence of three distinct signaling modules in the apoptotic intrinsic pathway 637 581 331 PMC3097943__F1 Role IL-6 signaling in CCA inflammation-related epigenetic regulation 1956 1326 1786 6774 4771 3716 PMC3102695__F5 Ciliary Neurotrophic Factor Induces Genes Associated with Inflammation and Gliosis in the Retina: A Gene Profiling Study of Flow-Sorted, Müller Cells 9826 25875 6774 10365 2670 7343 1050 PMC3102743__F7 Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin 4838 8928 8320 64321 PMC3106338__F10 INTERFERON-ALPHA MEDIATES THE DEVELOPMENT OF AUTOIMMUNITY BOTH BY DIRECT TISSUE TOXICITY AND THROUGH IMMUNE-CELL RECRUITMENT MECHANISMS 3627 324 6737 7038 7253 4938 PMC3107100__F1 Genetic alterations in glioblastoma signal transduction pathways (adapted from Parsons et al) 1956 1030 6714 4193 5728 4763 8626 PMC3108474__F2 Membrane type-MMPs regulate vascular cell signaling in cancer 6714 5159 5155 1839 2475 7077 4313 4318 PMC3109490__F1 Francisella tularensis tularensis targets the PI3K/Akt pathway at multiple levels 7097 406947 5728 PMC3112459__F1 TGFB signalling pathway and breast cancer susceptibility 8425 4053 4052 7040 7042 7043 7048 7046 4092 4091 4090 4086 4088 4087 4089 PMC3114474__F1 Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer 1956 2065 3082 PMC3115056__F1 Regulation of neural process growth, elaboration and structural plasticity by NFKB 1270 627 4803 8717 6714 3932 6850 PMC3118351__F10 Pathways by which BrdU impairs epithelial repair and induces persistent inflammation in the chronic NA injury model 545 472 3569 PMC3121598__F10 The interplay between leptin, IGF-1 and AB42 10682 3480 3667 3479 PMC3128904__F2 NOD-like receptor (NLR) family and inflammasome 10392 64127 64170 8195 PMC3130335__F1 MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells 3667 8660 5894 3480 1956 PMC3131055__F1 Wolbachia-induced responses of specific cell types 941 942 958 4615 10333 7097 7098 54106 929 4118 7099 3553 2919 2920 PMC3131835__F3 Sphingosine 1-phosphate (S1P) generation and ALI-associated single-nucleotide polymorphism (SNPs) in the S1P biosynthetic pathway 7124 1901 1903 960 PMC3133882__F4 Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment 324 4018 2932 PMC3136221__F1 “big picture” between DM2 and cancer 3479 3480 2475 PMC3137149__F1 Simplified model of the tuberous sclerosis complex signaling pathway 7248 7249 6009 64798 2475 PMC3137161__F1 Roles of shati on dopamine uptake – the relationship shati and TNFA 7124 6717 4280 PMC3138532__F1 HNSCC tumor microenvironment 1950 3480 1956 2885 6774 2475 6714 PMC314316__F1 Schematic model indicating the presence of two potential insulin receptor–dependent signal transduction pathways 8773 324 6844 PMC3146023__F3 Human spermatogonial stem cells: a possible origin for spermatocytic seminoma 2668 5979 2353 4613 PMC3148026__F2 Pathway alterations involved in the development of low-grade serous carcinoma 3845 673 2475 595 PMC3153486__F5 Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT1) Receptor Blockade 487 488 489 444 10345 7134 7125 7138 7139 7135 58 70 59 PMC3158334__F1 Possible mechanisms of opioid receptor mediated influence of morphine on tumor growth 1950 6714 572 387 595 4342 PMC3159971__F2 Mathematical model of dual negative feedback regulation of JAK2-STAT5 signaling 2056 2057 3717 9021 PMC3161420__F1 Regulation of apoptosis by the BCL-2 family 355 572 90427 637 581 PMC3163839__F2 Sirt1 activity as it relates to AD etiology 2309 102 5915 23411 PMC3165467__F6 Results of Ingenuity pathway analysis 350 7885 1991 PMC3175751__F2 Schematic Overview of Nodal and Cripto-1 Signaling Pathways 4838 6714 4088 4089 4087 PMC3180377__F9 Toll-Like Receptor 2 Pathway Regulates the Ppargc1a/b Metabolic Co-Activators in Mice with Staphylococcal aureus Sepsis 7097 7099 114609 4615 51135 7189 7098 7187 3665 3661 10891 PMC3183286__F2 The role of sphingosine kinase localization on substrate utilization and delivery of S1P to specific sites for secretion or loading of intracellular effectors 10519 7186 3065 3066 8717 PMC3184987__F5 Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component 3394 1958 1959 942 3399 5079 3398 929 916 3596 930 2205 2207 PMC3188357__F2 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), is the major genotoxic heterocyclic amine generated from cooking meats at high temperatures 1544 1545 1543 55023 PMC3188682__F3 TGFB1/SMAD3 signaling as an integrator of fibrotic mechanisms in the kidney 375616 3082 655 1956 6714 6497 7392 PMC3191464__F2 Model depicting the pathway of TGFBeta-mediated Bim regulation and apoptosis 4088 4089 861 2309 PMC3193402__F2 Crosstalk between RANKL- and TNF-induced NFKB signaling in OCs 7124 7187 5971 PMC3194983__F1 Inhibition of the type I interferon (IFN) induction and signaling pathways by viral proteins of KSHV 3454 3455 7297 3716 7098 7099 339855 29110 4599 6772 6773 PMC3197531__F12 Beta-Adrenergic Receptor-PI3K Signaling Crosstalk in Mouse Heart: Elucidation of Immediate Downstream Signaling Cascades 2475 2931 2932 PMC3201973__F9 Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway 5727 6608 2736 7098 355 6469 PMC3202302__F1 Signaling by the TNFR superfamily in B-cell biology and disease 7186 958 4790 2638 PMC3202302__F2 Signaling by the TNFR superfamily in B-cell biology and disease 613 958 5971 PMC3202302__F5 Signaling by the TNFR superfamily in B-cell biology and disease 958 7186 7189 7187 PMC3214144__F1 HCMV promotes GBM pathogenesis 595 5156 3091 4313 4318 2932 50943 920 PMC3216277__F5 Pathways underlying the absorption of cholesterol from the intestinal lumen and its delivery to the liver 39 29881 64241 64240 PMC3217183__F5 Signaling components of the RAS/MAPK pathway found to harbor activating mutations in various types of nevi and melanoma 2767 4827 673 4286 PMC3223033__F6 Schematic illustration of the main metabolic pathways based on the proteins identified in the citrus pulp chromoplasts 2147 2158 2159 PMC3224200__F1 Contribution of chemoattractant GPCRs to glioma stem-like cell mediated tumorigenesis, invasion and angiogenesis express various GPCRs 7852 1956 6774 PMC3224806__F1 Deciphering the role of Th17 cells in human disease 3458 4283 3627 324 PMC3225017__F3 c-MET transactivation 3082 960 3383 5266 6714 2885 PMC3230300__F2 Mucins in the Pathogenesis of Breast Cancer: Implications in Diagnosis, Prognosis and Therapy 3383 1950 367 1956 1610 581 2002 59330 2064 PMC3230686__F3 Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27 6774 6772 4088 196 4094 50943 861 6097 PMC3233530__F2 Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis 1387 2885 7874 9100 5520 7534 3845 673 5295 5925 5894 5286 6597 4838 657 658 7046 91 92 4088 4086 4089 PMC3236512__F2 Effect of FXR activation on triglyceride and cholesterol metabolism in the liver 6342 64241 64240 255738 335 5444 5465 3156 338 4023 7436 3949 7038 PMC3240717__F9 Pro-inflammatory Cytokine/Chemokine Production and Breast Tumor Invasion 960 4615 3553 PMC3243812__F8 Beta2-adrenergic receptor engagement on a B cell that will make IgE uses a unique signaling pathway to increase the level of IgE produced 958 3566 102 6778 PMC3246677__F2 Regulation of viperin expression 3466 23586 7098 7099 57506 3661 3665 3659 PMC3247963__F7 Model illustrating that early and late ISGs induction is regulated by multiple STAT1 posttranslational modifications 3455 3454 7297 PMC3249418__F3 Migration of marginal zone precursor B cells regulated by type I interferon (IFN) and IL-17 10563 643 5132 920 969 942 PMC3252833__F3 Sensitisation of type 2 cancer cells towards DR-induced killing by synthetic IAP antagonists 637 836 331 PMC3255978__F7 Proposed mechanisms underlying the regulatory control of fibrosis development by the PAI-1/uPA balance in aged-associated muscle dystrophy progression 5340 4092 5728 4087 PMC3256879__F8 A hypothetical diagram of the involvement of ATF6 in BMP2-induced osteoblast differentiation 650 22926 860 PMC3260854__F6 FosB-mediated regulation of ECM genes by mechanical signaling in bladder smooth muscle 3371 3725 2354 PMC3260860__F6 Scheme of the EGR-1/GGPPS/ERK 1/2 pathway 2885 2002 1958 PMC3264680__F3 Diagram of IGF/INSR/IGF1R signaling pathway 3630 3479 3481 3480 3482 PMC3266773__F10 CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression 970 939 7186 23043 1499 613 7422 861 51176 PMC3271643__F3 Putative mechanism of estrogen action in rat Sertoli cells 1956 6714 595 PMC3272682__F1 Recognition of Pathogenic Nucleic Acids by Patterns Recognition Receptors and Signaling 7098 51284 4615 8178 PMC3273421__F2 Myostatin and activin signaling in muscle 4088 4087 4089 PMC3273665__F2 SREBPs in the innate immune response 7099 7098 54106 4615 114548 3553 3455 3454 PMC3273847__F1 Innate Immunity in the Host Defense Against intestinal Bacterial Pathogens 4615 7098 7099 10392 64127 7189 51284 3661 3665 3553 PMC3277713__F1 A schematic diagram of different components making up the interleukin-23 (IL-23) and IL-12 receptors and the common signal transduction and activator of transcription 4 (STAT4) activation pathway 149233 3594 3595 7084 3717 7297 6775 PMC3278889__F6 CD40 signaling to the alternative NFKB pathway 958 7187 5971 PMC3283716__F1 Novel Classification of Lung Cancer into Molecular Subtypes 5728 3845 572 637 2475 596 PMC3304673__F1 Association of the canonical interferon pathway with the IRF5 haplotype 3458 3455 3716 3717 7297 6773 8519 4599 3437 10379 6772 PMC3305403__F4 The Nucleoside Diphosphate Kinase Gene Nme3 Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance 221472 4832 6010 PMC3307977__F6 Schematic diagram of the FGF2-STAT3-PAX3 signaling pathway 2247 6774 5077 PMC3310875__F6 Progesterone Receptor Activates Msx2 Expression by Downregulating TNAP/Akp2 and Activating the Bmp Pathway in EpH4 Mouse Mammary Epithelial Cells 650 652 4090 4086 4488 PMC3313452__F4 The noncanonical NFKB pathway 7187 7186 5971 PMC3313594__F3 Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery 4090 4086 4087 4088 4092 7018 PMC3313594__F5 Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery 4090 4086 4089 PMC3316122__F2 Schematic model depicting activation of the AIM2 inflammasome by F 3553 3454 3661 9447 PMC3322224__F2 cAMP Signaling CascadeLigand binding (represented in this example by PTH, but other ligands and receptors can stimulate cAMP synthesis), activates GsA and stimulates cAMP synthesis by adenylate cyclase 5741 5144 5573 PMC3329512__F3 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism 5091 5132 4311 PMC3329512__F4 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism 5132 23152 5091 PMC33333__F2 Role of the antioxidant response element and the transcription factor Nrf2 in chemoprevention 9817 4094 4899 PMC3336361__F4 Apoptosis pathways 637 581 331 PMC3338129__F2 Crosstalk Between Reverse Cholesterol Transport and Innate Immunity 6868 7099 7096 7097 7124 19 9619 4615 3717 6774 51311 54106 51284 7098 3661 PMC3342058__F2 Major therapeutic targets for inhibition of donor-reactive memory T cell responses 1043 939 970 940 941 2475 942 29851 PMC3342562__F6 Schematic representation of the role of H2S in atherosclerosis 3383 7412 1636 595 PMC3350083__F1 Overlap in FcERI, FcGRIII, and FcGRIIB signaling 7040 4067 2534 6850 1445 PMC3350990__F2 Bioinformatic analysis of the differentially expressed proteins.The list of the MS-identified protein spots from 2D-DIGE was subjected to String (v 2783 1742 3312 1845 1737 3098 9908 1808 PMC3355838__F1 Step model of thyroid carcinogenesis 7157 1499 7253 673 5728 PMC3355967__F1 Schematic of exosome secretion in a cancer cell model 5873 5874 84932 9367 5868 5872 PMC3355968__F1 Regulation of FOXO3 and Beta-catenin by AKT, ERK, and IKK signaling pathway 2309 4193 1499 6502 PMC3357552__F7 TLR4 signaling in alcoholic steatohepatitis and fibrosis 7099 7046 3661 4615 7098 6348 6351 6352 3458 7040 4087 1277 PMC3358519__F1 Schematic diagram of the cholinergic anti-inflammatory pathway (CAP) 43 6774 3717 PMC3359728__F3 Regulation of homeostatic AMPAR trafficking and turnover 627 23237 1000 1499 PMC3364930__F5 Subcellular localization of components of the PIWI-piRNA pathway and the proposed mechanism of TE suppression by this pathway 56165 122402 84944 54456 23468 29947 1656 PMC3368076__F6 Proposed mechanisms of leptin and glucocorticoid stress hormones in the GSK3B/Beta-catenin signaling pathway 3717 6774 2932 1499 PMC3376735__F2 Regulation of the TGFB–BMP receptor complexes by reversible ubiquitylation 11059 57154 23327 9958 PMC3377831__F1 Biosynthesis and catabolism of melatonin 15 1557 1544 8086 1543 1545 PMC3379801__F8 p16-Cdk4-Rb signaling pathway diagram 1019 1021 1029 1030 PMC3379883__F2 Leptin and the CNS Control of Glucose Metabolism 3717 9021 6774 PMC3382229__F4 Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis 84447 8542 3240 1668 29993 1669 10204 6441 6590 6374 6359 PMC3382313__F1 The role of Notch ligands in our models 54106 7297 3716 4615 6773 6772 28514 54567 920 7054 PMC3383648__F1 Vismodegib 6608 5727 51684 2735 64399 8643 2737 2736 PMC3385961__F1 Evolution of Wnt pathways 6259 2932 324 6010 1499 6714 PMC3385990__F3 Gp130 mediated IL-6 family of cytokines signaling pathway 3569 6774 2885 8651 9021 PMC3387977__F3 Targets for inhibition within the EGFR signaling pathway 7039 1950 1956 2475 PMC3388731__F5 Canonical Hedgehog signaling 5727 6608 595 4609 PMC3390194__F1 Personalized Medicine and Inhibition of EGFR Signaling in Lung Cancer 7039 1950 1956 5728 2475 PMC3391966__F1 Model of hedgehog action in the fetal male reproductive system 6469 50846 5727 2735 7536 PMC3393131__F1 Wnt/Beta-catenin signaling in T cell immunity and cancer immunotherapy 1499 4041 4040 324 607 6304 7008 5626 PMC3396155__F5 The balance in signalling through either ALK-1 or ALK-5 regulates leptin expression in MSC 4087 4086 4090 PMC3397239__F2 Anaplasma phagocytophilum: deceptively simple or simply deceptive? 6093 6850 836 841 331 PMC3399969__F5 State-of-the-science: An update on renal cell carcinoma 2932 7248 7249 6009 PMC3403683__F1 T cell receptor (TCR)-mediated signalling pathway 5064 324 27040 3932 2534 7535 4827 PMC3403928__F4 Caspase cascade 731 7124 718 PMC3405917__F1 Wound repair and fibrosis 85480 7124 64806 90865 7908 7040 PMC3406244__F3 Thyroid Hormone Receptors and Cancer 6714 1499 4313 4318 1356 2475 8178 6667 PMC3407375__F3 MicroRNA Circuits in Transforming Growth FactorB actions and Diabetic Nephropathy 6935 9839 4088 7391 4193 7030 4904 PMC3407815__F1 The interleukin (IL)-12/IL-23/interferon (IFN)G pathway and its role in mycobacterial disease control 958 3716 3717 3394 6772 PMC3408345__F6 Glucocorticoid (GC) actions in the airways epithelium 6772 6256 10891 3665 3661 6773 10379 PMC3409438__F2 Broad receptor antagonism and attenuation of downstream signaling cascades mediated by decorin in tumor cells 7422 1499 4609 27250 4313 7057 7078 1026 3593 7124 7097 PMC3409633__F1 TLR signaling controls transcription and mRNA half-life 7099 51135 3654 PMC3410677__F9 Schematic representation of potential interaction between the Rho GTPase signaling pathway, CTGF, and NMU in regulation of actomyosin-based contractile force and ECM protein profiles in TM cells 387 6010 10874 PMC3413220__F1 LCAT functions potentially affecting the pathogenesis of cardiovascular disease 19 9619 3931 338 PMC3414724__F1 Major components of the PI3K pathway in B cells discussed in this review 613 930 5266 5728 4067 6850 PMC3417478__F1 Cyclic AMP elevation leads to induction of the SOCS-3 gene in VECs 9021 6774 6670 PMC3418323__F4 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor 2249 3976 2932 6774 79923 PMC3418323__F5 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor 2249 3976 3716 2885 79923 6926 PMC3418560__F5 Schematic representation of a case of malignant myeloid disease evolving in four stages along one pathway 2120 861 171023 3717 2146 54790 PMC3418714__F2 Integrin signaling in CLL 613 695 4067 6850 29760 PMC3418714__F3 Kinase inhibitors in CLL 613 695 4067 6850 29760 PMC3420817__F6 12-LIPOXYGENASE AND THE REGULATION OF HYPOXIA-INDUCIBLE FACTOR IN PROSTATE CANCER CELLS 5728 2475 3091 PMC3425527__F1 Hedgehog signalling 5727 6608 51684 2735 2736 PMC3429585__F1 DKK1 as a novel target for myeloma immunotherapy 22943 958 1235 920 941 940 942 1234 1236 PMC3431702__F7 TLR signaling and proposed model for DMF-mediated impairment of DC maturation 7099 7096 7097 10333 7100 4615 51284 7098 3654 7189 7124 29110 3661 PMC3434281__F6 Proposed model for attenuation of canonical TGFB SMAD and activation of non-canonical TGF-Beta-NFKB signaling pathways in HNSCC 7040 4087 4088 4092 4089 PMC3436276__F7 Model illustrates proposed two pathways of regulation of S100A4 mediated by HBXIP 1786 6775 51199 5728 6275 PMC3438361__F2 Illustration of the metabolic pathway analysis for zidovudine with thick arrows indicating targets identified by the automatic classifier 7364 275 4693 2593 64078 9356 10864 9376 55867 1571 1559 1576 PMC3443855__F7 Nodal Signaling via an Autocrine Pathway Promotes Proliferation of Mouse Spermatogonial Stem/Progenitor Cells through Smad2/3 and Oct-4 Activation 4838 4087 4088 4089 595 PMC3443857__F1 Progesterone regulated paracrine signaling model depicted within the uterine compartments at the time of embryo implantation 4582 3549 650 9464 54361 PMC3444627__F1 Cytokine Combination Therapy Prediction for Bone Remodeling in Tissue Engineering Based on the Intracellular Signaling Pathway 650 4087 4088 1499 4090 4086 860 9242 5741 PMC3457296__F8 LMP2A induces signaling pathways that promote membrane localization of AV-integrin and epithelial migration 6850 6714 2932 PMC3460904__F7 Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours 4838 3624 10468 367 4087 4091 64750 57154 4092 4088 4089 3397 3399 3398 PMC3466334__F1 Genetically-defined metabolic reprogramming in cancer 26227 11113 4118 PMC3469658__F6 Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes 397 84817 4671 1495 836 84941 3329 85451 7124 1992 5536 84666 9948 PMC3472623__F1 Folate metabolic pathway 4524 635 4548 4552 7298 1719 PMC3482366__F1 Summary of folate metabolic pathway 1786 1788 1789 4548 4552 4524 PMC3484277__F2 Insulin like growth factor (IGF) and insulin receptor (IR) signaling system 3479 3481 3482 3480 2475 PMC3486458__F7 AMPK/ERK/TSC2/mTOR signaling in PCV2-induced autophagy in PK-15 cells 5894 7249 2475 PMC3488095__F8 A model for SAHA mediated effects on A1AT folding and trafficking 10956 6400 80267 821 PMC3491806__F2 Inflammatory Bowel Disease 920 3717 1235 PMC3493824__F2 Cellular Targeting in Autoimmunity 933 1234 920 1230 PMC3494243__F2 Pathways for C18 PUFA conversion to C20–22 PUFA synthesis 9415 3992 60481 PMC3495805__F1 Functional roles of pluripotency transcription factors in mesenchymal stem cells 79923 652 1786 PMC3501082__F7 A model to depict Tollip cooperating with Smad7 to mediate degradation of the TGFB receptor complex 10716 54472 717 4092 PMC3501616__F4 Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome wide association on chromosome 1p22 7020 8626 3664 7043 9411 387 PMC3502787__F1 General features of the HER family 1950 1839 7039 2932 572 2475 PMC3503525__F1 WNTS AND TGFB IN SYNAPTOGENESIS: OLD FRIENDS SIGNALLING AT NEW PLACES 4131 1499 4089 324 2932 PMC3504253__F2 Activated Wnt pathway 324 1499 4040 4041 PMC3505266__F3 Heterogeneity in the differentiation and function of memory B cells 920 59067 613 PMC3508562__F2 Genomics in cardiovascular diseases: analysis of the importance of the toll-like receptor signaling pathway 929 7100 7099 7098 4615 114609 51135 3654 51284 51311 54106 7189 29110 3661 PMC3513217__F2 Schematic illustration of irinotecan disposition pathway 5243 4363 1244 1577 1576 324 9429 54658 54600 PMC3513881__F3 Proposed three pathways for the mechanism of nicotinic acetylcholine receptor (nAChR)-mediated survival signal transduction 3717 2534 6774 PMC3514827__F1 Using components of the Vitamin D pathway to prevent/treat colon cancer 22943 7421 324 1499 3398 3397 6925 PMC3515677__F1 Summary of the mechanisms of DC-mediated HIV-1 transmission to CD4+ T cells 920 7852 1234 3383 PMC3516599__F1 Proposed Multicompartmental Degradative Pathway of L-lysineL-Lysine degradation is initiated by either peroxisomal Alpha-deamination (pipecolate pathway) or mitochondrial E-deamination (saccharopine pathway) 10157 51268 132949 51166 55526 2639 PMC3518543__F4 NFKB activation pathway is regulated by S-nitrosylation 6714 7099 114609 4615 PMC3518628__F3 Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS 3458 8313 1499 11201 246751 PMC3524085__F7 Ingenuity pathway analysis of the 10-edge pattern subgraph showing cancer-associated interactions among its nodes 6776 9939 6774 9612 2908 8648 1387 5970 PMC3528279__F3 RIG-I/MAVS signaling pathway regulating hMPV-induced NFKB and IRF activation in airway epithelial cells 57506 10010 29110 3661 PMC3531240__F11 IFNA and LPS up-regulate APOBEC3 (A3) mRNA through different signaling pathways 7099 4615 3661 6772 PMC3531289__F1 Chapter 3: Small Molecules and Disease 9317 1636 64782 PMC3532456__F3 Interleukin (IL)-13 and IL-4 signaling pathway 7297 3717 3716 3718 6774 3598 3597 PMC3534787__F9 Vorinostat, an HDAC Inhibitor Attenuates Epidermoid Squamous Cell Carcinoma Growth by Dampening mTOR Signaling Pathway in a Human Xenograft Murine Model 5728 5266 2475 PMC3538421__F5 Diagram showing the fundamental steps and P450 enzymes involved in vitamin D biosynthesis and degradation pathway 120227 1591 1594 7421 PMC3549263__F3 Low-dose radiation responsive genes linked to carcinogenesis 3667 6667 3622 5111 PMC3552884__F8 Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells 9451 468 54541 2475 29904 PMC3553975__F8 Subnetworks identified from (a) Loi et al 5594 5599 2885 2887 23542 6777 2002 5468 10617 604 2353 9612 3725 30836 6258 861 6996 PMC355851__F8 Proposed model for the observed inhibitory effects of Alpha-catulin and Alpha-catenin on the activation of cyclin D1 transcription 6010 1499 595 PMC3560376__F2 The TLR9-Notch ligand (dll4) on Mycobacterium-dependent granuloma formation 54106 4615 7054 54567 1235 6364 6367 PMC3562679__F1 Lipopolysaccharide (endotoxin) signaling pathway 7099 929 7189 4615 3929 PMC3564490__F3 Proposed alternative pathway of feto-placental androgen synthesis from 17-hydroxypregnenolone 3284 5447 1586 3293 6716 PMC3568263__F2 Defective counterregulation and hypoglycemia unawareness in diabetes: Mechanisms and emerging treatments 1392 23237 4922 PMC3571707__F1 Adaptive Immune Responses and HER2/neu Positive Breast Cancer 3146 920 4615 PMC3573791__F1 The metalloproteases meprin A and meprin B: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis 847 5045 4827 1950 PMC3574275__F1 Structural and functional characteristics of the human CD38 molecule 613 930 952 7852 975 7226 PMC3575708__F8 Model for Ctip2 functions in the proliferation and differentiation of epidermal keratinocytes 1950 1956 4851 PMC3578301__F3 Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets 717 920 6778 3932 2625 PMC3579281__F1 Simplified overview of inflammation-orchestrated signal transduction that induces pro-tumourigenic responses in glioblastoma 1950 3579 3577 1956 3717 6774 PMC3581417__F1 Synthesis of DNA precursors in the cytosol and mitochondria 7083 1633 7084 25939 PMC3581520__F1 Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis 10400 1120 1119 5091 254531 79888 54947 10162 PMC3586350__F8 Proposed Adipose Stromal Cell-derived IL-6 signaling pathway 3717 3716 7297 6774 PMC3587307__F1 LEM2 is a negative regulator of ERK signaling during muscle differentiation 1950 1499 2475 PMC3589914__F5 Regulatory circuits operating in osteoblast lineage cells 860 650 100422910 100616250 10014 4090 23314 468 PMC3594951__F1 This figure schematically shows the tyrosine kinase receptors, such as RET, EGFR, FGFR, MET, KIT, VEGFR, PDGFR, and some of their downstream effectors 1956 3815 5979 5728 673 2475 PMC3601410__F2 Most of the studies on Nrf2 and obesity-metabolic syndrome have focused on liver and white adipose tissue 6256 196 355 26291 6720 4851 2167 PMC3602699__F9 Summary of signaling pathway by which PP-fold peptides increase cell proliferation 4852 5697 10399 2475 PMC3606047__F1 Adenosine Signaling During Acute and Chronic Disease States 196 134 135 136 140 PMC3607163__F1 Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential 1499 1855 324 2932 6908 595 4040 4041 PMC3607541__F6 Interleukin-1 alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil 51284 4615 3665 6347 6374 6354 3579 729230 PMC3613056__F7 Pathway scheme of baicalein on the cell proliferation inhibition and cell metastasis inhibition in human bladder cancer cell 5637 2932 4318 4313 595 891 PMC3617041__F6 TGFB restoration by SMAD6 knockdown 4091 4087 4088 PMC3620096__F1 Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles 23682 10981 7306 PMC3621012__F2 Regulation of miRNA biogenesis and turnover in the immune system 4609 3654 7189 4602 PMC3622313__F1 Regulation of HDL homeostasis by miRNAs 19 3931 9619 1071 8647 5205 3949 7038 PMC3627331__F1 CD30 signals through TRAFs: upon stimulation by CD30L, CD30 recruits TRAF2 via interaction with its TRAF binding motif, resulting in TRAF2 degradation 7124 958 8717 7186 7187 5971 PMC3627549__F6 Decreased Hepatotoxic Bile Acid Composition and Altered Synthesis in Progressive Human Nonalcoholic Fatty Liver Disease 9420 80270 6718 1582 1593 570 25801 PMC3628745__F2 New signaling network for melanoma 10563 4254 1301 3371 54361 1956 2263 2261 5792 3815 6714 399694 4893 673 63928 324 4286 PMC3629761__F3 B-cell receptor (BCR) signaling pathway and potential targets 613 84433 695 4067 6850 PMC3630382__F9 Major interaction in top network 4869 1050 7984 2624 6434 PMC3632064__F3 Motor axons release Agrin and ACh 4038 4593 1399 1398 285489 PMC3634439__F3 StarD7 in various cellular events in JEG-3 cells 9429 5091 56910 1499 PMC3635737__F8 CCDC22 deficiency in humans blunts activation of proinflammatory NFKB signaling 28952 54951 150684 PMC3640511__F3 PRR activated signaling and antiviral responses during virus infection 7097 7099 7098 51311 51284 54106 57506 114548 9447 3428 3553 3434 51428 9208 3665 1499 3627 3659 3660 3394 PMC3641182__F2 Humanin: a harbinger of mitochondrial-derived peptides? 1271 581 6774 3486 PMC3641842__F1 The complement system 718 720 710 721 717 1604 4179 1378 4155 5648 727 729 730 7448 735 PMC3642145__F2 FIP1L1/PDGFRA+ eosinophil signaling.FIP1L1/PDGFRA+ primary eosinophils express upregulated IL-5 receptor (IL-5RA) and JAK2/STAT5 pathway may be involved in FIP1L1/PDGFRA induced disease development(; ; ) 1232 3568 3717 PMC3642326__F7 CQ excites TRPA1 and TRPC3, sensitizes TRPV1, and inhibits TRPM8 through different signaling mechanisms 79054 7442 8989 7222 PMC3644824__F2 A schematic diagram of Mycobacterium tuberculosis (Mtb) infection and clearance via the autophagic pathway 3458 80712 51762 345611 7010 PMC3649201__F1 Current view on the complex interplay of pathogenic factors in cholesterol gallstone formation 64241 64240 471 PMC3649977__F2 STL-based Analysis of TRAIL-induced Apoptosis Challenges the Notion of Type I/Type II Cell Line Classification 596 637 581 729 331 PMC3656449__F6 The pathway triggered by Tat and leading to activation of ISGs by Tat in APCs infected by HIV 3661 200315 10561 4939 3665 4938 6772 PMC3657461__F4 The JAK/STAT signaling in prostate cancer 3569 3717 6774 672 367 467 PMC3659771__F1 Notch signaling in the vasculature 3714 182 54567 28514 10683 4855 4851 4854 4853 3955 5986 4242 9794 3516 PMC3659771__F2 Notch signaling in the vasculature 7422 2296 2303 4851 23462 2050 PMC3660716__F1 Intracellular signaling pathways recruited by leptin 3717 9021 2885 6774 2475 PMC3660856__F3 Molecular Basis of DNA Recognition in the Immune System 114548 9447 3553 PMC3670000__F2 Signaling pathways used by GH to regulate growth and metabolism 3717 6714 2885 6772 6774 2475 PMC3670239__F1 Infection-induced IL-10 and JAK-STAT 929 3716 7297 6774 8651 9021 6772 PMC3674015__F1 (A–C) Schematic overview of particle-based vaccines 920 942 940 958 PMC3674381__F7 Model of XIAP as a switch between type I and type II signaling 637 581 331 PMC3674463__F1 EGFR pathway and downstream signaling pathways, including KRAS 1956 3845 5728 673 PMC3674567__F4 Postulated model for regulation of large luteal cells of ruminants (left) and primates (right) 847 5743 6770 5228 1583 PMC3681501__F5 Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway 10644 3480 8091 894 3481 PMC3686324__F1 Osteoporosis – a current view of pharmacological prevention and treatment 4040 4041 847 5741 PMC3687803__F1 Different layers of the epidermis, and the functions within those layers regulated by VDR and its coactivators 7421 26154 6785 7357 929 6714 2312 PMC3687803__F3 Canonical wnt signaling pathway 22943 324 2932 PMC3689995__F7 Dual functions of Smad2 in the maintenance of hESC and mEpiSC pluripotency 4087 4088 79923 4086 4090 5225 1045 PMC3691204__F1 Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma 6608 8643 5727 64399 51684 2735 27148 374654 2737 2736 PMC3691611__F7 The proposed pathways that regulate astroglial CNTF 7070 3569 1270 3976 6774 PMC3696572__F1 Linking MLL and the HGF-MET signaling pathway in liver cancer 619501 3082 4312 PMC3698571__F2 Advances in targeting cell surface signalling molecules for immune modulation 958 940 939 324 151888 3902 PMC3700727__F1 The Aryl Hydrocarbon Receptor: A Novel Target for Immunomodulation in Organ Transplantation 7018 405 196 1543 1545 PMC3703753__F2 Impact of Subarachnoid Hemorrhage on Parenchymal Arteriolar Function 1839 1956 339855 PMC3707951__F3 Proposed intracellular effects of S100A1, S100A4, and S100A8/S100A9 2638 6261 6262 6271 1499 6275 4856 6279 6280 PMC3709248__F4 Nitr9L–Dap12 activation of cytotoxic cells 100132285 2534 3932 6714 7535 6850 PMC3712075__F6 Schematic diagram showing the involvement of CPT1C and ceramides in the hypothalamic ghrelin signaling pathway 126129 1374 390259 4852 181 PMC3712126__F2 Bcl-2 family-regulated pathway and phenotypes in Bcl-2 knockout mice after status epilepticus 637 581 90427 572 PMC3719407__F4 Functional link between the BMP system and GnRH-induced FSH transcription 654 655 4090 4086 4091 4092 2488 PMC3720155__F2 Sketch of the relationship between IGF signalling, the PI3K pathway and androgen responses in the prostate 3479 3481 5728 8821 PMC3721230__F1 Mechanisms of action of lipopolysaccharide (LPS) as a sepsis inducer 929 4615 7124 PMC3721730__F1 Intrinsic and ER pathways of apoptosis 572 581 331 PMC3721836__F9 Simplified model of Rac1 signaling and function in learning-induced adult neurogenesis 627 5879 3725 4616 1641 PMC3723343__F3 Cripto/GRP78 modulation of the TGFB pathway in development and oncogenesis 4838 6997 6714 4087 4088 PMC3724874__F7 Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest 581 572 596 PMC3730813__F1 Pattern Recognition Receptors in Intestinal Inflammation 58484 114548 3553 PMC3731320__F1 Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway 5066 7124 64127 7097 PMC3731360__F6 Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia 1493 952 613 7535 10451 6772 4773 596 4609 PMC3733544__F7 FA/BRCA DNA damage response pathway 83990 672 675 79728 29089 7398 PMC3733582__F3 Pathway Linker Results for AChE and BChE 590 100529141 284217 8292 351 43 9421 1282 3912 PMC3735202__F3 Schematic diagram showing the Ras signalling pathway and its linkage to the GTPase cellular motility axis (Reproduced with permission from) 1950 5900 572 388 PMC3736507__F2 Schematic diagram showing that cartilage matrix homeostasis is adjusted dynamically by TGFB signaling pathway 4090 4086 4087 4089 PMC3737294__F1 Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance 4199 2805 11113 2806 2746 4118 PMC3737583__F8 Working model for how ERA may modulate signaling by TLR-activated DCs 5132 149233 3553 55364 PMC3740204__F2 Angiogenesis pathway of FAK, EZH2 and Dll4/Notch in cancer-associated endothelial cells 7422 1869 6714 1871 4851 22846 2146 4855 PMC3745214__F4 Targeting TGFB signaling in cancer 4087 4088 4089 7018 PMC3745819__F1 A CENTRAL ROLE FOR INDUCIBLE HEAT SHOCK PROTEIN 70 IN AUTOIMMUNE VITILIGO 958 941 9308 942 920 PMC3748035__F1 Dynamic regulation of P2X4 receptors in microglia 3458 717 627 100170220 PMC3748765__F1 TCDD-induced CTLA-4 on AhR-Treg activating the tolerogenic IDO pathway and suppressing the acute GVH response 920 3458 6772 941 942 196 PMC3749067__F1 Wnt/Beta-catenin signaling pathway 2932 324 1499 PMC3750319__F2 Canonical, non-canonical and the atypical NFKB signaling pathway 7124 958 472 PMC3753234__F7 Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway 2247 6714 387 PMC3753467__F1 IP3 instigates the activation and amplification of NFATc1 7189 9846 5336 4772 PMC3759173__F3a Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy 3934 6262 287 55504 3122 23643 3109 3108 3111 8710 8738 6885 8942 64332 PMC3759196__F9 Aberrant Signaling Pathways in Glioma 6469 4855 4853 4851 4854 5727 6608 4090 4086 2736 2737 2735 6774 4089 7128 648 8295 10215 3569 PMC3764071__F1 One-carbon metabolism and glutathione (GSH) synthesis and metabolism 9118 4548 635 PMC3767467__F4 Proposed model of TRP47 effector function in E 2534 84333 5771 PMC3772104__F1 The involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis 4014 3718 3716 6778 2625 50943 PMC3774847__F1 Schematic model of GMIP and Slp1/JFC1 regulation of vesicular dynamics and exocytosis in neutrophils 5873 51291 387 PMC3774987__F3 Essential TLR-associated signaling pathways and cytokine production 7100 7096 7097 7099 81793 114609 7098 4615 51135 7187 7189 3663 3661 PMC3775269__F6 CTLA4Ig inhibits effector T cells through regulatory T cells and TGFB 940 942 941 324 3458 PMC3775648__F1 Major elements of the canonical Wnt signaling pathway 11197 2487 7471 7472 7482 7473 89780 54361 22943 27123 7475 7476 7477 7478 7479 7483 7484 7480 80326 7481 51384 27122 27121 83999 79412 4041 4040 8321 2535 8322 7855 8324 8325 8326 1855 324 2932 8312 1499 PMC3776465__F2 Functions of the proteins encoded by the genes mutated in primary lymphedema cluster around a central molecular pathway: the VEGFR3 signaling 147372 7424 3832 54345 5629 2624 2324 2303 5784 PMC3782845__F4 Possible origin of WM precursors from IgM+ memory cells 930 939 2638 PMC3786223__F2 The potential role of miRNAs in the attenuated myogenic process in the elderly 3479 993 997 4088 4087 PMC3800064__F2 The canonical and noncanonical NFKB pathway 7187 5971 5970 PMC3800433__F1 The central role of group 2 innate lymphoid cells (ILC2s) in type 2 immunity 1956 196 64806 90865 85480 PMC3804348__F1 Regulation of lipid metabolism in glioblastoma and the therapeutic drug targets 3620 3949 355 19 2475 PMC3805859__F1 Integration of microRNA and epigenetic regulation pathways 2146 1788 6895 27161 26523 3065 PMC3808414__F8 Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy 2539 56937 4092 5170 5820 2335 PMC3808429__F6 Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology 25 3312 4792 2064 1956 5295 3320 1499 2932 1147 4790 PMC3809843__F9 Gremlin regulation of LOXs in TM 7048 7046 659 4088 4087 4089 4015 4016 4017 84171 PMC3812807__F7 PKCE ACTIVATION PROMOTES FGF-2 EXOCYTOSIS AND INDUCES ENDOTHELIAL CELL PROLIFERATION AND SPROUTING 3791 2260 6774 PMC3814227__F2 Autophagy: regulation 3667 6009 23411 PMC3817019__F2 EGFR pathway and its main downstream effectors, PI3K/AKT and KRAS/BRAF/MEK/MERK.Notes: Activated AKT and MEK/MERK can induce cancer cell proliferation and invasion 1956 3845 673 PMC3817541__F1 Mechanism of activity-dependent transcriptional repression by MeCP2 4204 627 266743 PMC3819805__F11 Folate biosynthetic pathway in Plasmodium falciparum 2643 1725 1719 PMC3820259__F2 Roles of lipids in the tumour microenvironment 2194 355 4018 2167 PMC3820561__F1 BRCA1 domain structure and subcellular transport pathways 580 672 10763 PMC3822435__F3 Molecular Pathogenesis of Endometrial and Ovarian Cancer 672 675 5728 1499 PMC3826451__F2 Toll-Like Receptors (TLR) signaling pathway involved in RSV and hMPV-induced gene expression 4615 3661 7099 7098 51311 51284 PMC3829478__F9 Wnt3a binds to Fz7 and cross-activate the IGF-1-PI3k-Akt pathway inducing initial axonal outgrowth and neuronal polarization 89780 7473 3480 8324 PMC3829926__F1 Phosphatidylinositol 5-phosphate is a second messenger important for cell migration 200576 5266 8897 PMC3834144__F8 Schematic summary of OPRM1 differential signal pathways upon acute and chronic morphine administration 4988 6714 5894 PMC3837032__F7 Impaired Nrf2 activation and antioxidant gene expression in fetal endothelial cells in GDM 9817 2932 4094 PMC3840213__F8 Graphic summary of factors regulating Beta-cell proliferation and size as a function of pancreas developmental stages 5617 3481 5618 PMC3842585__F2 Mutations in the ERK/MAPK signaling pathway and related second messenger systems 154865 389158 2804 7444 55277 1647 2932 221037 PMC3843069__F1 Tryptophan metabolic pathway 4129 4128 1644 125061 15 438 8942 130013 23475 PMC3843232__F1 Causal role for JAK2 V617F in thrombosis 3717 7173 4352 PMC3844070__F1 The IFNG signaling pathway 6772 3460 3459 PMC3844829__F3 Metacore™ apoptosis signaling pathway relating to mitochondrial proteins 3479 7124 355 572 637 581 8739 PMC3855473__F2 Tax-specific noncanonical NFKB pathway 958 7186 7187 5971 PMC3857329__F3 As discussed in the preceding sections, the catalytic activation method using HNTf2 allows efficient borylation with optimal substrates such as 22 4831 140805 7054 PMC3861040__F5 Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion 8074 2167 5199 4089 5741 PMC3864900__F6 Ubiquitylation in immune defence and pathogen evasion 940 83737 10892 8915 7189 PMC3865655__F1 Caveolin-1 is a highly versatile regulator of cell signaling 1499 595 6714 2886 1445 PMC3866688__F5 Targets of immunosuppressive drugs used in solid organ transplantation, according to the 3-signal model of T-cell activation 958 941 942 3383 3558 940 914 3718 2475 PMC3866828__F3 HVJ-E-mediated apoptosis pathway in cancer cells 841 836 842 3661 3665 57506 PMC3872295__F1 Mechanistic model to show how mechanical forces promote differentiation of fetal type II epithelial cells via release of soluble growth factors HB-EGF and TGFA with subsequent binding and activation of the EGFR and ERK signaling pathway 1839 7039 1956 6868 PMC3875765__F7 Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway 619501 80310 5159 PMC3878444__F6 The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro 54210 7097 834 3566 958 64127 PMC3880216__F5 Schematic diagram 581 572 2932 PMC3881602__F1 Interplay between regulatory T cells and metabolism in immune regulation 2475 253260 948 29851 1493 2625 50943 PMC3884575__F2 Schematic representation of complement-mediated effects on T cells and APCs 942 941 324 920 3458 PMC3885992__F5 Polarization of immune cells in the tumour environment by TGFB 4087 4088 4089 4092 PMC3886813__F2 NFKB and STAT3 signaling in glioma: targets for future therapies 5008 3717 6774 PMC3887753__F1 Sequential pathway leading to renal ischemia-reperfusion injury 1234 7097 3579 PMC3887911__F4 CRAC channel regulation by multiple Ca2+-sensing molecules in the ER and cytoplasm 84876 84766 6786 PMC3889683__F3 Schematic presentation of potential signaling network of HER2-NFKB-PI3 K-Akt-STAT3 5328 5783 5925 79884 6774 PMC3891517__F3 Possible mechanisms of opioid receptor-mediated influence of morphine on tumor growth 1950 6714 572 595 387 PMC3892938__F2 A schematic representation of IL-12 family cytokines and the corresponding receptors and JAK-STAT signaling pathways 10148 3594 3595 149233 7297 3717 6774 6772 6775 3586 3458 PMC3909817__F4 Potential mechanisms of TGF-Beta-induced upregulation of Nox4 gene expression 4087 4088 50507 PMC3912412__F6 Interaction of CLL cells and the lymph node microenvironment 933 3553 3566 7128 7124 2213 9308 971 1846 1844 1843 717 643 2354 2353 3726 3727 PMC3912696__F1 Role of cytokines in Th1 and Th2 differentiation of lymphocytes 3586 3458 7124 920 4283 3627 6361 6367 6369 PMC3917351__F1 Ca2+ transport remodelling in promotion of cancer cell proliferation 7225 7222 55503 7226 79054 54822 84876 6786 93129 PMC3917351__F3 Ca2+ transport remodelling in the promotion of cancer cell metastasis 6275 55503 79054 51393 7442 54822 PMC3917548__F1 The interleukin (IL)-21 receptor signaling pathway 50615 3718 126669 6774 PMC3920945__F3 Oncogenic and tumor suppressive autophagic pathways involved in miRNAs 406959 407006 407007 9759 10014 2308 4303 PMC3921546__F1 Representation of epidermal growth factor receptor pathway in response to therapy with anti-epidermal growth factor receptor inhibitors in wild-type and mutant patients 1956 3845 5728 673 2475 PMC3923981__F7 Cytosolic Functions of MORC2 in Lipogenesis and Adipogenesis 22880 47 355 PMC3924201__F2 Hippo pathway-mediated regulation of cell lineage and pluripotency by adhesion and epithelial polarization in the early mouse embryo 154796 9113 26524 4771 847 79923 1045 PMC3929401__F1 Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta 4599 3716 7297 3454 3455 6778 6772 6773 6775 6774 PMC3934442__F5 Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis 387 6093 9475 2274 6722 PMC3937046__F7 Neuronal circuit diagram of the light input pathway in the tadpole retina 5015 3670 5629 5080 7054 260402 PMC3939471__F1 Involvement of CD81 in Hepatitis C Virus (HCV) lifecycle 7124 967 975 9076 1956 100506658 3949 3265 29881 PMC3942504__F1 Molecular mechanisms of Bcl-6 expression in T cells 3458 643 6772 6775 6774 29851 5728 2308 23035 940 PMC3942542__F1 Cyclic adenosine diphosphate ribose mediated Ca2+signaling 7226 952 6786 PMC3944232__F7 Schematic illustration of LEF1/CYLD and cIAPs in the modulation of RIP1 deubiquitination and triggering of apoptosis via caspase-8 1540 51176 637 PMC3947043__F1 Molecular alterations and biomarkers in colorectal cancer 864 8913 3481 4762 8835 5290 7157 324 7048 3845 387569 673 5728 1499 PMC3947362__F7 The proposed model for the signaling events in mature, human oligodendrocytes in response to B. burgdorferi 6347 3576 6352 PMC3948775__F2 Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat 6820 51478 1586 9420 3292 412 3283 51144 1589 3293 1312 3291 7923 PMC3949417__F1 Sensing of transferrin-bound iron and regulation of hepcidin expression in hepatocytes 7018 148738 3077 4090 4086 4089 PMC3949576__F2 Effective double whammy targets DNA synthesis in leukemia 4693 7083 1633 PMC3953345__F2 Schematic presentation of the molecular mechanisms of myogenic differentiation 1499 4617 4656 5077 4222 PMC3957919__F7 Proposed model depicting the role of IFI35 in negative regulation of RIG-I signaling 57506 3665 3661 3430 PMC3962044__F3 IAP antagonists and NFKB signaling in osteoclast lineage cells 8737 8717 7186 7187 5971 PMC3969038__F1 NFKB signaling pathway and cancer related mutations 4615 84433 8915 5970 PMC3969039__F2 Putative model of the mechanism of vascular homeostasis mediated by apelin-APJ signaling 5053 10365 2247 2260 PMC3969300__F1 Establishment of left/right (LR) asymmetry during development 4838 653275 5046 93 PMC3972113__F13 Overexpression of miR-125a in Myelodysplastic Syndrome CD34+ Cells Modulates NFKB Activation and Enhances Erythroid Differentiation Arrest 7097 7096 10333 4615 7128 7189 7018 114609 PMC3972679__F2 Apoptotic pathways induced in beta cells in type 2 diabetes 3375 114548 3603 572 637 581 PMC3973244__F7 Role of RNase L and TLR3 activation during inflammation in insulin response of obese people's myotubes 7099 4615 6041 3667 3661 7098 9021 PMC3980848__F3 MicroRNA Regulation of T Helper Cell Differentiation and Plasticity 8651 50943 6772 604 9612 29102 PMC3985001__F1 The CNS-immune system crosstalk 181 7432 4852 2922 1103 7124 PMC3989450__F3 Wnt-dependent interactions between cardiac myocytes and cardiac fibroblasts after acute myocardial infarction 7474 89780 6423 7471 1499 6424 6422 PMC3990910__F3 Mechanisms of Notch signaling silencing in AML 9794 55534 388585 3955 4853 PMC3998120__F4 Origins of Metastatic Traits 7412 6714 7852 7422 9595 PMC3998825__F1 Alternatively Activated Macrophages Revisited: New Insights into the Regulation of Immunity, Inflammation and Metabolic Function following Parasite Infection 90865 6761 50615 3597 3662 9314 6778 PMC4000238__F2 The canonical Wnt, Ihh, Bmp and PTH/PTHrP signaling pathways in regulating the differentiation of mesenchymal precursors 6662 1280 860 5741 3549 PMC4001041__F1 Schematic illustrating NLR attenuation of canonical and non-canonical NFKB signaling 958 91662 4615 3654 7187 79671 7189 197358 5971 PMC4001295__F7 Opposing TNFA/IL-1Beta- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation 650 3553 4090 4086 860 PMC4002662__F2 Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling 1956 7186 7189 7188 7185 5970 PMC4005353__F1 AGS genes cooperate to metabolize reverse transcription products of endogenous retroelements 25939 11277 29110 3661 PMC4009339__F3 Gene network of T-ALL (early response) derived from GeneMANIA (a) and STRING (b) (NR3C1 interaction is highlighted) 5927 5447 2288 64839 2908 2289 2353 373 3725 4678 PMC4011807__F1 Pathophysiology of anthrax illustrated as a series of steps 5045 4040 84168 118429 PMC4012865__F9 Activation of DCs by HKBA showing the stimulation of TLR2 and TLR9 and cross-talk between their respective signal transduction pathways 7097 4615 54106 7124 PMC4012967__F1 IL-6/JAK/STAT pathway 1950 3570 1956 9021 5979 6714 6774 595 PMC4013640__F2 Pericyte physical and biochemical interactions at the NVU 7048 1000 5159 PMC4014576__F6 Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling 841 836 5728 PMC4015472__F3 Post-Transcriptional Regulation of Interferons and Their Signaling Pathways 3458 3717 6775 3716 3459 2597 6772 8320 100313837 3460 PMC4020352__F1 Noncanonical transforming growth factor B signaling in scleroderma fibrosis 1490 6714 4086 4087 PMC4020352__F3 Noncanonical transforming growth factor B signaling in scleroderma fibrosis 5728 4087 4088 4089 5494 PMC4021516__F7 Wild-type p53 (WT-p53) and mutant p53 differentially regulate Nox4 expression in both TGF-Beta-dependent and independent mechanisms 7046 4087 4088 50507 PMC4022192__F5 TLR-induced signalling pathways 7099 7096 7097 10333 114609 4615 51284 3665 3661 PMC4023360__F1 Role of Heat shock protein-27 (HSP27) and clusterin (CLU) in cancer cell survival 3479 3480 7124 355 1191 1616 637 572 581 367 PMC4024337__F4 NFKB gene signature predicts prostate cancer progression 7227 4218 2147 891 9518 7498 3156 6714 3706 409 1960 PMC4026077__F1 Inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells 6608 5727 2736 2737 2735 147040 4609 64399 PMC4026397__F4 Role of NADPH Oxidases in Liver Fibrosis 7099 100188864 4087 4088 4615 114609 25805 3656 3654 51135 4089 7189 50507 3553 PMC4026680__F1 Early life stress can influence development of the HPA axis, as well as regulation of satiety-related hormones, leptin, insulin, and ghrelin to alter feeding behavior long-term 1392 551 23237 PMC4027966__F3 Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes 10159 23150 54331 3778 51096 4830 7172 3704 PMC4032097__F9 CNTF-induced gliosis in the retina after ONC and Pen1-C6DN + siCASP2 treatment 839 1270 835 1271 PMC4033012__F2 Schematic representation of the NALCN channelosome 846 259232 285175 57578 PMC4033570__F5 Simplified network diagram showing the involvement of JNK and p38 in the system 7189 5008 3716 6774 PMC4034063__F1 Core hypothalamic energy homeostatic circuit and the dopamine reward pathway 4160 23237 4852 5443 181 PMC4041745__F4 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome 2147 624 7225 7222 387 847 PMC4042299__F3 The role of epigenetics in the biology of multiple myeloma 1499 11197 1021 1019 10401 6774 8651 PMC4043736__F3 Patterns of Gene Expression Associated with Pten Deficiency in the Developing Inner Ear 11170 83715 51083 5816 PMC4050127__F1 Targeting LIM kinase in cancer and neurofibromatosis 4763 387 5879 3985 PMC4050248__F7 Protein kinase C epsilon (PKCɛ) is a major regulator of mitochondrial nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide adenine dinucleotide (NAD) 10135 3091 349565 PMC4050971__F3 Ingenuity Pathway Analyses: Pathway analyses were from the commercially available Ingenuity Pathway Analysis software 7773 1356 467 3665 7224 4803 6754 5924 PMC4052589__F1 Possible mechanisms of the opioid receptor–mediated influence of morphine on tumor growth 1950 6714 387 595 572 4342 PMC4055918__F1 Erythroid DAMPs drive inflammation in SCD 7099 9332 1773 PMC4060203__F1 Schematic showing the details of the estrogen pathway 1586 3283 1588 1312 3292 PMC4061041__F6 ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence 472 3479 3480 1958 PMC4061475__F1 Dopamine biosynthetic pathway 2643 7054 5053 PMC4062953__F1 Steroid hormone synthesis pathways in the adrenal gland and testis 6770 412 1583 1586 3293 3284 8644 1585 1584 3291 3290 PMC4064060__F1 The Wnt/Beta-catenin signaling in epithelial cells 4041 4040 324 1499 595 960 4920 6010 9475 85451 PMC406426__F1 What is the role of mTLR7 in the antiviral response? Many ssRNA viruses (including VSV and influenza viruses) engage host cell receptors that trigger endocytosis 7098 4615 29110 54106 3661 51135 7189 PMC4070007__F1 Simplified diagram of the TLR-mediated and interferon (IFN)-mediated immunity in response to viruses 7015 7098 51135 7187 3665 3661 PMC4074217__F5 Comparison of apoptotic pathways and NLRP3 inflammasome activation 637 847 9927 57506 114548 PMC4074572__F1 Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology 7099 7097 4615 2475 114548 2919 2920 6348 6352 10563 PMC4074825__F3 FHIT-substrate complex as a signaling molecule 1950 6714 2272 PMC4075245__F1 Simplified schema showing how genes might affect clinical responses to targeted therapies 26191 1493 1235 640 7185 23569 958 3572 3663 6775 51744 7124 PMC4077663__F2 Leptin–brain melanocortin system interaction 5443 4160 9118 PMC4077717__F1 Overview of the general innate immune response to viral infection 3455 3454 3588 7098 115004 3428 7297 3716 4615 57506 29110 6772 10379 3661 3665 4599 4938 5371 3434 9636 8519 9023 91543 25939 684 PMC4077879__F1 Selective autophagy against membranous compartments 7939 665 9528 9821 22863 55054 PMC4078307__F1 Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival 7054 1644 1621 5409 PMC4079587__F5 Interaction of kisspeptin, estrogen and BMP-4 in regulation of GnRH production by GT1-7 cells 652 4091 4090 4086 PMC408363__F1 Complexity of the CD28/CD152–B7-1/B7-2 T-cell costimulatory pathway 940 324 1493 PMC4083841__F1a Beta-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis 2057 3717 2056 PMC4087671__F1 Control of the TRAF6 signalosome by miR-146a 4615 51135 3654 7189 6772 7852 PMC4089153__F1 Sooner and later 3146 64806 85480 PMC4090148__F11 Evidence that RASSF1C Stimulation of Lung Cancer Cell Proliferation Depends on IGFBP-5 and PIWIL1 Expression Levels 3488 9271 1499 472 PMC4090390__F1 Pathogenesis of T2D: adipose tissue, the pancreas, NLRP3 and T2D 3375 3553 3667 PMC4091098__F1 Heat shock protein-CD91 pathway mediates tumor immunosurveillance 325 942 958 920 PMC4095017__F2 Signaling and cross talk of the parathyroid hormone and Wnt signaling pathways in the late osteoblast (osteocyte) 5741 22943 4041 4040 89780 2147 8313 PMC4096962__F6 Combinatorial cytokine regulation of iNOS expression in IMF 3458 6772 3553 PMC4099360__F1 Toll-like receptor 4 and hepatic fibrogenesis 7099 3929 929 7189 3661 114609 4615 PMC4101967__F2 Interference with type I IFN-activated JAK/STAT signaling pathway and antiviral ISGs 3455 3454 7297 6773 10379 9636 3836 3837 PMC4102648__F2 UV signaling pathways within the skin 4157 7306 5144 4286 PMC4102778__F7 GSK-3 as potential target for therapeutic intervention in cancer 6608 5727 51684 2737 2736 2735 51715 595 596 3481 PMC4104069__F2 Pathways to Tumorigenesis and Persistent Infection 7099 4615 3654 7098 3661 PMC4109802__F2 Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration 2247 2260 4345 PMC4110160__F1 Differential LSEC Signalling in Models of Acute or Chronic Injury 2260 7852 7472 3082 PMC4118716__F2 Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis 920 3553 3716 3717 7297 3718 2625 6774 6778 6775 PMC4128061__F2 Activation and regulation of BMP/Smad-dependent signalling 5494 4091 64750 57154 4092 25805 PMC4130149__F1 An integrative overview of intracellular signaling pathways by the IL-1R, TLRs, NLRs, and CLRs upon an innate immune response to microbial infection or cell death 7099 114548 8767 4615 6850 3603 PMC4131533__F8 Interaction network of differentially expressed miRNAs and their targets: network construction can be divided into two components: miRNA-target and target-target interaction, and candidate miRNA targets were predicted by mRDB 442892 407010 9241 64750 494337 3458 3625 650 4093 10468 7046 7048 6198 3400 4088 693167 5516 92 5515 7042 83729 5308 5933 406976 4087 4089 PMC4133771__F1 Possible signaling of G 1499 627 2931 2932 1630 10371 PMC4134018__F3 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii 7792 8678 596 597 PMC4142057__F1 Activation of NFKB signaling through canonical and alternative pathways 4050 958 7124 5971 PMC4147035__F1 NFKB: A Coordinator for Epigenetic Regulation by MLL 5970 3205 4211 84444 PMC4151374__F1 Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation 9379 3909 5621 3818 5340 2885 348 10817 PMC4151534__F2 IL-1A and IL-1B synthesis and signal transduction pathway 7850 4615 51135 3654 7189 3550 3553 PMC4153443__F1 The mammalian circadian clock 26224 9575 6095 406 PMC4155833__F3 Dual role of Nrf2 in cancer.Notes: As long as it is kept under homeostatic control, Nrf2 activation protects cellular components like DNA from damaging insults arising from acute/temporary oxidative and xenobiotic stress 2810 3845 9817 PMC4156318__F2 ATM-NFKB-regulated signaling network causing the adaptive resistance to IR in normal human skin epithelial HK18 cells 472 891 595 PMC4157971__F7 Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1–NFKB pathway in BMP-2 expression 7099 650 4851 PMC4158833__F4 Shaping the mammalian auditory sensory organ by the planar cell polarity pathway 57216 5754 1855 22881 PMC4161359__F2 Feedback pathways of AR, PTEN, and PI3K 2475 367 2146 3725 2289 1958 PMC4162195__F6 Working model 4851 3280 388585 PMC4164328__F2 Intracellular pathway associated with GHR activation in hepatocytes 2690 3717 3479 1956 PMC4164328__F3 Intracellular pathway associated with IGF1R activation 3630 3479 3481 3480 3482 2475 PMC4172957__F6 Expression of genes in the canonical complement system pathway 718 720 721 729 727 1431 PMC4174300__F2 Innate immunity to dengue virus infection and subversion of antiviral responses 57506 7098 7189 7187 3661 PMC4174300__F3 Innate immunity to dengue virus infection and subversion of antiviral responses 57506 7098 7187 7189 3661 107966124 PMC4174300__F4 Innate immunity to dengue virus infection and subversion of antiviral responses 6773 7297 23352 10379 PMC4174666__F4 Generation of a biological network of genes related to the upstream regulator IRF2 5196 9111 7412 3433 3659 3660 10346 85441 10135 6761 6774 1786 892 5270 57817 PMC4176007__F3 IL-6 synthesis and regulation of IL-6 mRNA stability by Arid5a 7099 10865 4615 PMC4179633__F7 Lcn2 role as a negative regulator in NFKB-STAT3 loop activation in macrophages 7099 3934 6774 PMC4179756__F13 Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27 331 27429 8213 PMC4180659__F1 Perpetuation of innate immune responses in sJIA 4615 7189 7124 PMC4189494__F6 Schematic representation of the negative regulation of TLR3 and TLR5 signaling by MUC1 4615 3661 4582 7100 7098 PMC4195781__F1 Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia 374654 51684 2121 PMC4200333__F9 Signaling pathways involved in TC adhesion-induced ICAM-1 expression on ECs under flow chamber conditions 960 3383 6667 PMC4203530__F1 Dark side of Toll-like receptor signaling 1950 6774 6714 3082 4615 54106 3146 3067 54210 7040 PMC420513__F4 Immune synapse_related signaling pathway and autoimmune diseases 2534 27040 3932 5335 26151 5133 6583 861 865 3383 914 940 941 920 PMC4209143__F3 Macroautophagy in the immune system 920 54106 613 PMC4209605__F1 Cutting the brakes and flooring the gas: how TMEPAI turns TGFB into a tumor promoter 4087 4088 6010 5728 4089 4609 PMC4214130__F5 Hypothetical pathway analysis depicts mitochondrial dysfunction 57546 5164 3553 PMC4216593__F8 Although distal 11q copy number loss, from band 11q14 to 11qter has been reported in many types of tumors, its significance had not been investigated until our previous study () 11200 472 545 1111 PMC4217731__F7 Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice 5465 1375 10891 1327 1374 PMC4218725__F6 Shigella dysenteriae Modulates BMP Pathway to Induce Mucin Gene Expression In Vivo and In Vitro 4089 1045 4583 4586 PMC4229635__F6 Shed Sdc-1 induces the activation of EGFR and downstream signalling pathways via sHB-EGF 4318 4316 1839 1956 PMC4232216__F1 BMP Family and Signaling Pathways 151449 392255 27302 650 652 653 655 654 4090 4086 651 649 10220 9210 4089 4091 4092 PMC4239504__F2 Molecule-mediated signal pathways in the propagation of liver cancer during liver regeneration 4087 4088 4090 4086 2475 4089 PMC4249369__F1 Pantothenate and coenzyme A biosynthetic pathway 79646 55229 53354 80347 PMC4249724__F4 Müller glia cell reprogramming and retina regeneration 1499 3479 1839 6774 PMC4252069__F6 Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle 3479 442920 57521 2475 2308 1979 253260 8894 1982 1977 1983 8661 PMC4252624__F6 Classical Complement Pathway affected in the ovary of female LMB (by gene set enrichment analysis (GSEA)) 715 716 721 729 717 730 731 718 727 735 367 PMC4252843__F5 PROTEASE MEDIATED HUMAN SMOOTH MUSCLE CELL PROLIFERATION BY UROKINASE REQUIRES EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION BY TRIPLE MEMBRANE SIGNALING 1839 102 8038 1956 PMC4254647__F3 FA/BRCA DNA damage response pathway 83990 675 5889 79728 2072 29089 7398 PMC4254744__F6 HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes 7099 7097 4615 3146 PMC4254984__F4 C-peptide-initiated signaling cascades 115330 3667 387 PMC4255043__F1 Induction of nuclear factor-activated T cells c1 (NFATc1) in osteoclasts 126014 54209 10326 7189 9355 3423 3394 9935 759 2932 4772 PMC4255622__F1 Signaling pathways: HN exerts its function through both extracellular receptors and intracellular binding partners 128434 3717 6774 81559 3486 581 1270 PMC4259944__F1 Mutant epidermal growth factor receptor endocytic trafficking 1956 2064 1950 6714 PMC4259953__F3 Possible mechanisms of expression and functional regulation of tissue factor and coagulation factor VII in breast cancer cells 7018 2821 2152 2475 1956 5728 9759 1958 7391 PMC4268052__F6 Holoprosencephaly: signalling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans 6469 4838 2520 91653 6608 2736 4086 4087 4090 PMC4276949__F1 Hypothetical model of HGF/SF activation in cancer 6420 84000 3034 3082 9622 25818 6395 PMC4283135__F1 Canonical Notch signaling with points of intervention of current therapies 102 100188776 3516 50863 PMC4286324__F3 Schematic diagram describing Src regulation by trafficking 6714 388 10938 PMC4286424__F2 Signal transduction pathway of bitter (T2R), sweet (T1R2/3), and umami (T1R1/3) GPCRs in type II taste cells of the tongue 29850 255022 5330 PMC4292165__F2 Signaling pathway of endosomal TLRs 7098 51284 51311 54106 4615 51135 7187 29110 7189 3654 3569 7124 3665 PMC4292235__F1 Assembly and mechanism of action of CpG ODN/Tat nanorings 54106 4615 5132 920 3458 PMC4293489__F1 Activation of TLR4 by LPS 3929 7099 929 114609 4615 PMC4294374__F1 Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat 3479 255738 4040 3949 2475 7038 PMC4304082__F2 Piece #2: The BCL-2 family controls BAK/BAX activation and MOMP 572 637 581 PMC4308835__F1 Nuclear factorK B activation pathways 958 7099 929 5971 PMC4313732__F2 Cytosolic nucleic acid pattern recognition and activation of ISGs 115004 6041 6035 9023 11274 6772 3428 9447 57506 3665 3661 3659 PMC4313785__F1 Figitumumab (CP) is a biased agonist of the IGF1R that selectively promotes Beta-arrestin1 (Beta-arr1) signaling in cancer cells 3479 1356 3667 PMC4314111__F2 Rise of regulatory RNA 10664 26523 1788 29102 2146 PMC4315992__F8 Signaling pathways for PDGF-induced proliferation in PSCs 6714 6772 3717 6774 PMC4318882__F7 The murine parturition pathway 2548 3164 6777 PMC4322535__F3 Signalling pathway of renal tumour-propagating cell membrane markers and “cancer stem cell” markers 960 7852 10014 1499 4090 4086 79923 PMC4323367__F7 Summary of radiation-induced persistent alterations of IGF1 and leptin signaling pathways observed in our study 3480 3479 3717 3667 PMC4327859__F4 Post-transcriptional gene suppression mediated by miRNAs is involved in the fine-tuning of epithelial anti-Cryptosporidium defence 7099 8773 6376 3383 PMC4329480__F1 Molecular mechanisms regulating mitophagy 23274 84749 664 718 65018 PMC4332855__F3 Mycobiota: interactions between commensal fungi and the host immune system 6280 64581 64170 81704 3553 6772 6774 3594 PMC4336822__F3 Progesterone action in breast, uterine, and ovarian cancers 3479 22943 3549 9464 PMC4340906__F5 Induction of Indoleamine 2, 3-Dioxygenase in Human Dendritic Cells by a Cholera Toxin B Subunit—Proinsulin Vaccine 150684 4791 196 4790 2146 3725 23657 6772 7316 7305 3620 PMC4344387__F1 Wnt/Beta-catenin and Notch signaling pathways and pathway crosstalk as illustrated herein 51527 2932 324 847 3516 PMC4345858__F9 Acsl1‐dependent changes in metabolites in the biochemical pathway involving cysteine and glutathione metabolism 4144 51380 2939 2938 79094 PMC4349622__F3 Schematic diagram showing the multi-regulation loops of LRRC4/NGL-2, miRNAs, TFs and target genes in glioma 387 64101 29117 1786 6667 1876 4609 PMC4350284__F5 Activated SFK interfere with dimerization and nuclear translocation of pSTAT5A in BCR-ABL expressing cells 2056 9846 613 PMC4350910__F3 Pathway for the synthesis of the endocannabinoids AEA and 2-AG 7442 4099 2166 PMC4358129__F11 MiR-199a-5p in smooth muscle differentiation and hypertrophy 7472 8313 595 9314 6722 3399 10398 93649 59 4629 PMC4359241__F2 Androgen receptors beyond prostate cancer: an old marker as a new target 367 1576 1544 1559 6774 PMC4361590__F7 Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3B (GSK-3B) and Microtubule-Associated Protein 1B 374946 1630 2932 4131 PMC4362880__F1 Beta-amyloid precursor protein (BAPP) processing in Alzheimer’s disease (AD) and age-related macular degeneration (AMD) 54209 7305 23554 102 945 PMC4365881__F4 Extracellular regulation of satellite cell fate 1499 9672 5081 2247 6385 PMC4367559__F2 Mechanisms of resistance due to MET/HGF pathway and potential interventional strategies 3082 1950 1956 7422 PMC4367602__F2 Ligand stimulation of ERK and PI3K signaling in BRAFV600E melanomas 1950 3082 673 10253 1848 1977 PMC4369817__F6 Schematic diagram of the mechanism whereby miR-16 attenuation contributes to myocardial hypertrophy 6774 595 898 1019 PMC4370699__F5 Activation of CNTF/CNTFRA Signaling Pathway by hRheb(S16H) Transduction of Dopaminergic Neurons In Vivo 7248 7249 1270 PMC4377308__F3 Genetic alterations of protein tyrosine phosphatases in human cancers 6774 11122 790 5781 6714 PMC4379025__F12 Telomerase Inhibition Decreases Alpha-Fetoprotein Expression and Secretion by Hepatocellular Carcinoma Cell Lines: In Vitro and In Vivo Study 174 2475 6774 PMC4382094__F5 Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase 2010 637 2626 PMC4382258__F2 Essential role for autophagy in life span extension 7249 7248 8408 7942 PMC4383688__F1 Molecular Pathways: Aspirin and Wnt Signaling—A Molecularly Targeted Approach to Cancer Prevention and Treatment 4040 4041 1499 324 6934 4609 PMC4383744__F1 Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape 2271 718 1604 727 966 PMC4385526__F2 Innate immune evasion of hepatitis C virus infection 282617 7297 6773 3661 57506 7098 10379 163702 3454 3455 PMC4385831__F6 Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFA and ROS production 7124 7186 5971 8737 11035 8717 PMC4386371__F5 Model for the role of specific acyl-CoA oxidase homo- and heterodimers in the biosynthetic pathway of (omega-1)-ascarosides (A) and omega-ascarosides (B) 51 8309 735 8310 718 729 PMC4386408__F5 The mechanism of the switch off in Shh canonical signaling during spinal cord development 6469 6608 2737 2736 PMC4389010__F1 The Th17 pathway and its involvement in psoriatic disease 920 50604 3569 5132 59067 3586 6774 2919 2921 6372 6374 6364 3576 338376 4314 PMC4389797__F7 Schematic showing the TGFB/LIF- mediated tumor suppressive role in melanoma 4089 4087 6774 3976 581 PMC4391155__F5 The PVT1 functions 4609 5820 4839 PMC4392729__F4 Th17 counteracts the effect of IL6 3569 3567 7422 PMC4394497__F11 Findings from our laboratory using an animal model of the autoimmune disease, RA, reveal disease-related changes in B2-AR signaling that are dependent upon the lymphoid tissue examined 156 2869 2870 PMC4395516__F7 Reported interactions between factors associated with Peters anomaly 4693 7042 83959 3052 2316 5080 1545 7020 2296 5309 5308 2301 145173 PMC4398671__F8 Schema of structure and signaling pathway of G-CSFRI and G-CSFRIV 9021 6347 94241 PMC4399033__F1 Pyrimidine synthesis and salvage pathways in Toxoplasma gondii 1723 4975 139596 1283 PMC4399085__F3 PRC2-independent transcriptional activation by EZH2 in cancer 2146 1499 5970 5971 8726 23512 367 5928 6774 PMC4402192__F1 Canonical and noncanonical Wnt signaling pathways 4040 4041 324 1356 6010 PMC4402192__F2 Role of antagonists in Wnt signaling pathway 50964 4041 4040 324 847 2932 6010 PMC4404310__F1 Proposed schema of aberrant signal transduction mediated by the TSLPR heterodimer in CRLF2-overexpressing ALL 85480 2475 1977 PMC4405647__F13 Schematic presentation of molecular mechanisms by which acidosis controls the mTORC1 and eEF2K pathway to shut down protein synthesis and aid cancer cell survival 7249 7248 6009 29904 PMC4405749__F6 Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis 23411 2308 7874 581 PMC4407539__F8 Predicted model of the immune response of Epinephelus coioides larvae to V 718 716 717 5648 727 721 729 730 PMC4409274__F7 Cancer activates Stat3 in muscle to stimulate loss of muscle mass via two signaling pathways 6774 4087 4088 PMC4410569__F7 HJV and HFE Play Distinct Roles in Regulating Hepcidin 3077 148738 7036 PMC4419619__F1 Modulation of Insulin-Like Growth Factor-1 Receptor and its Signaling Network for the Treatment of Cancer: Current Status and Future Perspectives 3479 3481 3480 3667 PMC4424075__F2 Innate Immune Evasion by Filoviruses 7187 10010 29110 57506 PMC4428658__F3 Eculizumab and Recurrent C3 Glomerulonephritis 730 729 735 727 PMC4428674__F1 Mediators released from activated MCs 3815 4254 718 727 5226 4050 3553 PMC4428707__F11 SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation 929 7099 5879 PMC4429004__F4 Functional prions in immune signaling 1283 114548 57495 5548 57506 PMC4430931__F1 Signaling pathway of the extrinsic factors, glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) 2668 2247 2674 5979 3400 339345 2119 3975 255877 2308 PMC4432802__F1 Schematic representation of the principal pathways involved in glucose catabolism summarizing recent findings discussed in the Mini Review (red boxes) 5209 2597 3458 PMC4433279__F4 Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma 5728 2475 4919 PMC4436984__F2 Key signaling regulation of autophagy in the heart 3667 8660 8408 PMC4437198__F1 Genetic Variants in the Fibroblast Growth Factor Pathway as Potential Markers of Ovarian Cancer Risk, Therapeutic Response, and Clinical Outcome 2246 2252 2260 2263 PMC4442386__F8 Model for the overall disruption of IFN responses by SFTSV through NSs hijacking of signaling proteins in IBs 6773 29110 6772 3661 10379 PMC4443744__F2 Role of complement in physiology 2597 1378 2271 942 90865 1514 2475 PMC4445098__F6 Network between MAPK signaling pathway-related genes and miRNAs 7040 2317 3315 9020 7132 9344 7786 784 4216 10454 773 1843 5566 2318 2261 409 782 5582 6237 PMC4452148__F2 Notch signaling pathway 4855 4853 4851 4854 8650 100188776 4609 PMC4452354__F1 Schematic illustration of the transduction of signals from inflammatory bone diseases to brain-resident microglia through the leptomeninges and two different pathways for the IL-1B production activated by CGA and AB in microglia 3553 3603 1081 7099 114548 PMC4452855__F2 Types I and III IFNs canonical signaling pathways 3439 3441 3455 3454 163702 7297 6773 3661 3665 9636 8651 11274 3440 PMC4454381__F4 Regulation of autophagy by protein post-translational modification 8473 10724 3064 PMC4455035__F2 Pericytes, microvasular dysfunction and chronic rejection 627 387 51129 PMC4457157__F3 Crosstalk between growth factor and adhesion protein signaling 1499 6714 2932 PMC4459756__F3 Risk loci of human autoimmune diseases associated with the TFH developmental pathway 3592 149233 3593 6774 6775 7054 3663 3394 643 941 940 942 10538 920 29851 26191 PMC4460803__F2 Recently identified drivers in signaling pathways involved in adrenal tumorigenesis 1584 6770 1589 79798 55366 84133 8323 4040 PMC4461483__F4 Possible role of Naa10 in cellular hypoxia 9112 8260 47 PMC4464690__F3 Crosstalk between Wnt, PTH and BMP signalling in cartilage and bone cell lineages 5741 9242 22943 4040 4041 PMC4464753__F7 Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus 3479 627 348 7124 3553 3481 3480 3667 PMC4465570__F3 Genome-wide association study points to multiple loci predicting antidepressant treatment outcome in depression 338 5445 100188864 948 2950 2053 6262 3037 7132 5796 5734 4605 27242 5802 PMC4467417__F5 Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/Beta-catenin pathway 83737 89780 1856 PMC4468292__F1 Influence of the inflammatory cytokines on the status of insulin resistance 6774 7099 3667 PMC4468369__F7 Illustration for the mechanism underlying s-IL-15RA–induced EMT, migration, and invasion of human RCCs 6714 2932 1499 PMC4469332__F3 The production of BH4 within the DRG plays a critical role in pain signaling 2643 6697 5860 PMC4474402__F5 Dysregulation of astrocyte extracellular signaling in Costello syndrome 5411 3280 4774 2004 6591 PMC4480265__F2 Sensing of cell death by myeloid C-type lectin receptors 64170 10892 7124 2919 2920 PMC4482723__F1 Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease 6999 169355 3397 3398 8564 23475 PMC4483763__F5 Key signals mediating progenitor fate decisions during hepatogenesis 3082 5008 4838 PMC4489351__F1 EDA pathway and its downstream signaling 1896 10913 128178 7189 PMC4490961__F2 Interaction of the TFF2-CXCR4 axis with the active RAS-RAF-MEK-ERK pathway in the serrated pathway of colorectal cancer 7032 1950 1956 7852 PMC4491123__F1 The miRNA biogenesis and function 29102 5901 6895 27161 PMC4492816__F6 Definition of the early fracture healing pathwaySchematic detailing the role of the early inflammatory pathway in fracture healing 729230 6347 7124 5008 PMC4496399__F6 NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib 960 4803 389 387 PMC4498277__F2 Sclerostin actions 4038 4040 4041 5741 PMC4499885__F5 Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells 1950 7046 1956 6774 3716 PMC4505437__F8 CFZ inhibition of PTH-induced osteoclastogenesis 5741 7189 9759 PMC4508501__F1 miRNA biogenesis process 57510 27161 29102 PMC4513933__F2 Summary of the interactions between the PI3K/AKT pathway and RUNX2 with integration of the TGFB pathway 5728 2932 64750 860 4318 4313 4323 4322 6591 3549 6662 4088 PMC4517052__F1 Main metabolic pathway in the bioactivation and DNA adduct formation of BaP in lung 1543 1545 4353 PMC4526643__F2 Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model 11156 578 914 1356 4780 9402 1652 51 6304 PMC4531430__F6 miRNA–gene–pathway regulatory networks 2257 5565 7042 10451 4638 3717 2182 3673 2690 3158 3918 7292 3156 6387 PMC4533011__F1 iNKT cell activation pathways in sepsis 929 912 6295 324 PMC4533861__F7 CX3CL1-induced breast carcinogenesis in ErbB2 transgenic mice 6376 1839 367 1524 717 PMC4536758__F1 Idelalisib —targeting PI3KD in patients with B cell malignancies 6348 6351 6850 7852 643 613 6387 10563 PMC4536957__F2 Schema showing the multiple functions of FOXD1 lineage myofibroblasts in interstitial kidney disease 6469 9509 9510 81792 2191 4323 4316 7076 PMC4539617__F6 Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma 6469 2922 2925 6608 6010 PMC4543283__F1 New pathway for memory B-cell activation in systemic lupus erythematosus (SLE) 613 5132 29851 PMC4545436__F1 Signaling pathways involved in CSCs 6295 6469 5727 6608 324 2932 1499 2735 PMC4547588__F1 Interferons and other inflammatory cytokines control HBV infection of hepatocytes via multiple, distinct mechanisms 3553 7297 3716 10379 6772 6773 PMC4551213__F6 A force-sensitive signaling network involving TRPC6 and TRPM4 channels in cerebral artery smooth muscle cells 54795 367 7225 5335 6714 PMC4552732__F4 A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung 5053 56624 166929 8439 55304 PMC4558162__F1 OVOL guides the epithelial-hybrid-mesenchymal transition 6774 4089 655 474168 PMC4561113__F3 Notch-signalling pathway in macrophage reprogramming and its interaction with the TLR-dependent signalling pathway 7099 6774 7018 9021 3394 PMC4561339__F1 Schematic diagram of the protein components involved in the myelin protein-derived inhibition of neurite growth 4099 84894 387 718 PMC4567404__F1 A worm of one’s own: how helminths modulate host adipose tissue function and metabolism 920 7908 90865 PMC4569046__F5 Microbial subversion of neutrophil function leads to periodontal inflammation 727 7097 7096 57154 4615 4118 387 PMC4569902__F7 Schematic view of the integration of Sema3-Nrp with the Hh signal pathway by controlling PKA and PDE4 6469 6608 5144 PMC4570097__F1 T-MPs function as novel cell-free cancer vaccines 941 115004 942 PMC4571158__F2 A schematic presentation of secreted, endocytic, and signaling pattern-recognition receptors 720 721 717 940 718 PMC4572872__F2 Many anticancer agents mediate tumour cell killing though activation of the BCL-2-regulated apoptotic pathway 90427 572 581 PMC4578617__F1 miRNAs that control signaling governing osteogenesis and adipogenesis 650 4086 9242 1499 PMC4581061__F3 Induction of the extrinsic pathway of apoptosis by phthalates 7077 6667 355 PMC4588730__F2 Functions of FGF19 and the corresponding mechanisms 9965 2264 2260 PMC4589461__F1 Negative feedback regulation of bile acid metabolism: impact on liver metabolism and diseases 2264 1581 1593 9420 1582 4097 4280 PMC4593004__F2 Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan 6586 6091 23139 55770 59269 80036 64321 2494 56479 23362 152189 5867 5332 PMC4593152__F4 Conditional probability and local structure extracted from the simplified network, for calculating the indirect effect of this specific pathway (NAFLD, GGT1, GGT2, dyslipidemia, hypertension and MetS) 2678 100380876 4397 PMC4594188__F1C Significant signaling pathway networks in each group 6672 4609 1667 5966 5308 PMC4594188__F1E Significant signaling pathway networks in each group 6722 5914 10564 10369 135112 PMC4595346__F3 Connecting Myokines and Metabolism 10220 3479 238 4087 4088 4092 4089 2932 595 PMC4595469__F7 Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells 4277 100507436 1956 PMC4598795__F6 Cd-elevated genes associated with mitochondrial oxidative phosphorylation pathway that occurs in electron transport system 4709 4694 4711 4719 54949 PMC4602285__F7 The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease 317 840 836 5728 PMC4606066__F1 Expression and function of the insulin/IGF system in normal and colorectal cancer cells 3479 3481 3482 3667 2475 2932 1499 PMC4608393__F1 Schematic view of the LPS-mediated NFKB pathway 114609 4615 7189 PMC4613661__F1 Model for KSHV v-cyclin-induced dysregulation of Notch signaling during lymphomagenesis 4854 23462 3280 896 1021 PMC4615578__F9 The mechanisms of the miR-449a tumor suppressive function in neuroblastoma cells 4239 8502 116461 1021 51176 PMC4618389__F1 Vulture-specific genetic change in immune system 10392 64127 3929 929 3665 PMC4622840__F1 c-Met-mediated oncogenic signaling (from Peruzzi et al) 3082 2885 55364 367 PMC4623426__F3 Transforming growth factor B (TGFB) signaling pathways and aging 4092 4089 4088 4087 7018 PMC4623426__F4 Regulation of Janus activated kinase (JAK)-Stat and nuclear factor kappa B (NFKB) signaling by TGFB through MKP-1 6772 8717 7186 4092 4087 4088 7018 PMC4624297__F4 Comparison of typical innate immune signaling cascades (top panel) with those activated by CJD infection (bottom panel) 3454 3455 6772 10379 6773 3661 4599 9636 3627 PMC4630171__F12 Proposed model 595 51176 54361 1499 4041 PMC4631599__F9 Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells 7097 7099 5266 PMC4632302__F9 Diagram of signaling pathway for genistein-induced apoptosis in Bax and p53-independent manner 637 842 2021 836 317 PMC4633493__F1 Mechanisms through which microRNAs (miRNAs) implicated in the TGFB signaling pathway in the lung epithelial cells and fibroblasts 7939 64750 4087 4088 4092 407054 6774 4089 PMC4636224__F6 Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis 2065 2064 5728 PMC4637204__F4 Systemic Problems: A perspective on stem cell aging and rejuvenation 3717 7045 4086 4088 2475 6774 PMC4639852__F9 Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice 727 1956 3569 6774 PMC4640739__F7 Working model for Mek/Erk signaling in mouse ESCs 79923 63978 6926 9314 PMC4642996__F7 A proposed scheme for BRCA1 and Gamma-H2AX-dependent DNA repair in neurons under normal conditions and in HD 672 3014 472 PMC4646490__F8 Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway 1950 1956 2548 6714 PMC4654653__F2 Implications of microbiota and bile acid in liver injury and regeneration 1593 80270 9420 6718 1582 1109 25801 PMC4655955__F1 IPA prediction of the interactive network between the differentially expressed genes in the blood of triple negative compared to ER/PR+ breast cancer patients.Notes: Red – genes overexpressed; Green – genes underexpressed 3603 8741 10344 5008 10563 3440 PMC4657846__F2 Normal regulation of the complement AP 718 3075 3426 PMC4657846__F6 Sites of complement pathway dysregulation 3075 718 3426 PMC4658032__F8 MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NFKB Signaling Pathway Following Negative Regulation 7097 929 4615 9258 7124 PMC4658486__F4 Pathophysiology and management of CVD 3383 7412 717 105031671 718 727 729 PMC4658613__F6 Insulin-like growth factor-1 signaling with regard to Helicobacter pylori associated glucose dysregulation 3479 3667 3480 PMC4659440__F5 c-Met as a Target for Personalized Therapy 7425 1950 3082 1956 2475 PMC4661094__F2 RPE Necroptosis in Response to Oxidative Stress and in AMD 7186 8717 11035 197259 PMC4663159__F7 The integration of the DUOX2 system into the intestinal epithelial defense response 50506 130120 2919 6364 324 PMC4664912__F6 Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog 183 5550 290 5476 213 6395 551 4306 5294 1962 554 6340 127124 9296 PMC4665079__F2 Mitochondrial apoptotic pathway 317 27429 331 PMC4668540__F1 Sonic Hedgehog Pathway 6469 6608 5727 2735 2736 2737 PMC4669719__F8 Schematic diagram of the NRG1-ERBB4-NRG1 autocrine pathway 3084 2066 2064 PMC4672393__F1 Complement System and Antibody Mediated Transplant Rejection 2271 1378 720 721 727 PMC4673177__F8 Cerebral endothelial cell function by TGFB in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition 6615 1000 7450 7122 5281 PMC4684398__F6 Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKB and CREB Pathways and Negative ERK1/2 Pathway 3654 51135 4615 PMC4684475__F2 Inflammatory targets of therapy in sickle cell disease 7124 4615 8717 PMC4690755__F6 Novel pathways of apolipoprotein A-I metabolism in HDL of different sizes in humans 3931 19 9619 64137 7038 5360 1071 PMC4691146__F2 Processes affecting TOB1 levels and diverse mechanisms underlying TOB1 tumor suppression activity 10140 407014 6195 4089 5728 324 1499 6790 2932 581 595 PMC4693238__F3 Intracellular detection of viral RNA by PRRs and activation of the innate immune response 103 7098 51284 4615 57506 29110 3553 3661 3665 10379 PMC4693271__F1 Toll-like receptors (TLR) 4-mediated signaling of innate immune responses 7099 4118 4615 7187 7189 257397 23118 3661 5971 PMC4693276__F4 The synthetic lethality pathway model based on a deficiency in Alt-NHEJ and the double-strand break repair pathway 5426 675 672 PMC4693877__F2 Bacterial components that affect innate and adaptive immunity in the intestine 5132 196 920 PMC4693897__F8 Proposed mechanism for zinc‐mediated inhibition of interleukin‐1B (IL‐1B) signalling and its role for repression of human T helper type 17 (Th17) responses 3553 3554 51135 7189 4615 PMC4695067__F6 Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2 100187761 5646 1950 PMC4695108__F3 Regulation of Bim in Health and Disease 8655 1647 672 8239 PMC4695187__F8 Antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells 7124 637 331 PMC4695871__F2 Binding of the Hedgehog ligand (SHH) to Patched (PTCH1) removes the inhibitory signal for the G-protein-coupled receptor, Smoothened (SMO), causing translocation of the GLI1 and GLI2 transcription factors into the nucleus 6469 6608 5727 2735 2736 PMC4698274__F1 Innate Immunity against Leishmania Infections 718 7097 4615 7098 114548 54106 834 3553 3606 PMC4702030__F4 A - Ingenuity pathway analysis of genes involved in human epithelial ovarian cancer (EOCs) and other associated diseases that have overlapping pathways 472 1029 11200 2033 4763 5728 5925 7048 7157 PMC4705475__F6 RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism 5531 374 6693 57829 253980 9961 9378 10135 9344 6262 4140 7545 6911 9791 PMC4705593__F1 Cholesterol biosynthesis pathway 3949 19 3156 2224 2222 PMC4707216__F4 Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor 3082 6714 4313 4318 PMC4709508__F3 Toll-like receptors, adapter proteins, and signaling molecules 7097 7096 10333 7100 7099 54106 4615 114609 3661 51311 51284 7098 7189 PMC4714843__F7 Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi 1958 183 10253 3976 1843 3569 3567 81848 3596 6356 2920 4092 655 3397 4088 4091 3399 PMC4720884__F8 Hypothetical model of the signaling pathway through which MIF is involved in ConA-induced autophagic cell death of hepatoma cells 260402 4282 664 6774 PMC4721683__F4 Signaling pathways related to the activity of oxaliplatin and 5-FU for colon cancer cell lines 1956 4089 2932 3718 4087 4088 4763 8312 1499 324 2475 7046 PMC4724579__F2 Toll-like receptor 2’s signalling pathways contributing to hepatocarcinoma 7097 3303 3146 PMC4724579__F5 Toll-like receptor 9’s signalling pathways influencing hepatocarcinoma 54106 331 3146 PMC4725591__F2 BMP signal transduction 4086 4089 4090 4091 4092 PMC4730337__F1 EGFR transactivation by GPCR 1839 1956 2885 6714 PMC4731439__F1 TNFAlpha-related signal transduction pathway participating in the differentiation of skin appendages 5045 10913 128178 23118 7189 7187 1540 PMC4732808__F9 Blockade of KCNN4 by Clt accelerates wound healing at least in part by transactivation of the PI3K pathway 11113 1950 3783 1956 PMC4732899__F6 Epidermal growth factor receptor signaling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease 374 1956 324 3605 3565 PMC4736209__F3 Possible interaction between inflammatory IDO activation and AhR-mediated effects 6714 196 6774 405 PMC4736761__F3 Cellular processes common to all nine cancer stem cell- (CSC-) associated genes 4851 8842 1956 79923 648 960 6657 PMC4736825__F4 Model of translational repression of Nodal pathway components 4904 4838 2829 1999 PMC4737457__F4 Crosstalk between Wnt, Notch, and JAK-STAT signaling pathways 650 6774 3516 PMC4741654__F1 The complex metabolic network gearing the G1/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents 2271 1719 55349 PMC4741792__F6 GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells 6387 7852 3936 PMC4741987__F8 ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription 6667 7580 708 PMC4742390__F2 BMI1 regulates BCSC 22943 7471 648 84678 PMC4746688__F8 A Novel Pathway for Triacylglycerol Biosynthesis Is Responsible for the Accumulation of Massive Quantities of Glycerolipids in the Surface Wax of Bayberry (Myrica pensylvanica) Fruit 4099 5053 4018 PMC4748411__F4 Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model 1368 57561 3111 2908 93986 4103 60681 84560 PMC4749490__F1 Hypothesis: central neuroendocrine and peripheral mechanisms in generation of sex bias in PH 4280 857 5053 6776 604 PMC4752324__F8 Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension 5111 5817 50507 5053 PMC4752785__F3 Scheme of the molecular mechanisms that systematic exposure to cigarette smoke can influence during carcinogenesis of the mammary gland 1956 6714 1869 993 596 PMC4754058__F1 The Notch1 signalling pathway 4851 3480 864 861 PMC4755325__F2 The cGAS-STING Defense Pathway and Its Counteraction by Viruses 115004 8408 6048 79102 29110 81844 3661 22954 PMC4755870__F5 MicroRNA variants as genetic determinants of bone mass 6422 1499 324 23314 860 3206 PMC4761146__F9 Schematic diagram depicting the proposed signaling pathway involved in interferon-induced transmembrane protein 1 (IFITM1) upregulation in SUM149 cells 3455 7297 10379 8519 6773 PMC4761371__F2 RhoGTPase switch at the cell–cell contact 7204 1000 5879 7074 387 7410 144165 PMC4763179__F1 Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation 4086 4089 4090 659 85015 650 PMC4770095__F2 Regulation of Th2 Cell Immunity by Dendritic Cells 6761 958 1236 3566 9314 3662 3394 PMC4772696__F3 Role of EZH2 in genomic signaling through canonical and non-canonical activity 23512 8726 7018 PMC4774109__F2 Dysfunctional humoral response during visceral leishmaniasis 939 920 2638 PMC4785262__F3 Neutrophil Functions in Periodontal Homeostasis 727 7097 4118 4615 57154 387 PMC4786305__F2 The Herpes Simplex Virus Neurovirulence Factor G34.5: Revealing Virus–Host Interactions 3716 83939 6772 6773 10379 PMC4786634__F1 Both signal 1 and signal 2 are required for NLRP3 inflammasome activation 4615 114548 9927 57506 10628 3553 PMC4789659__F4 Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo 147746 204851 10114 28996 1613 1612 23604 8445 PMC4792095__F1 Inhibition of guanylate biosynthesis enzymes limits tumor invasion and growth 3615 3614 8833 2766 PMC4794363__F6 SGEF is Regulated via TWEAK/Fn14/NFKB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide 7186 391 4827 672 PMC4800028__F1 CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance 51094 79602 7099 948 PMC4800317__F6 Non-canonical or alternative NFKB pathway 4050 4055 958 7186 7187 5971 PMC4801721__F1 Methionine cycle and transsulfuration pathway 4397 635 875 PMC4802778__F2 Role of sortilin in EV biogenesis 26136 7792 5873 PMC4805479__F2 Involvement of dWAT in Hair Follicle (HF) Synchronization.Synchronous cycling of HFs is connected with long-range paracrine signaling 7421 5212 6469 PMC4809656__F8 Molecular mechanisms by corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway 2475 4851 9794 3280 PMC4811470__F2 Integration of tissue metabolomics, transcriptomics and immunohistochemistry reveals ERG- and gleason score-specific metabolomic alterations in prostate cancer 2194 6319 259230 PMC4814919__F9 Beta-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H 337 26291 4322 PMC4817727__F3 Role of axin in Wnt signaling in bone 4040 4041 324 1499 PMC4817802__F4 Role of histone PTMs in DNA damage repair 3014 6045 9810 56254 11237 55072 80352 80196 64320 79102 152006 140545 472 165918 9025 672 PMC4818578__F2 NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? 5053 50507 79400 3383 7412 27035 857 3479 2475 PMC4818674__F1 Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration 5728 387 2475 PMC4820873__F6 Schematic model of IGF1R-evoked and p110Beta-evoked resistance to p110A inhibition in PIK3CA mutant breast cancer cells 5290 3479 8660 3667 3480 2475 PMC4822253__F1 BMP pathway 7046 331 4090 4086 3399 3397 PMC4826392__F2 Pathways of DNA demethylation mediated by TET enzymes 2638 80312 200424 54790 29128 1786 6996 PMC4828118__F3 Drugs interfering with breast cancer (BC)- and obesity-related pathways 7249 7248 2475 3091 PMC4829957__F3 Targeting EPO and EPO RECEPTOR PATHWAYS in Anemia and Dysregulated Erythropoiesis 2056 2057 151176 5777 5781 3717 26469 PMC4831356__F1 Schematic model illustrating O‐GlcNAc pathway and influence of glucose and O‐GlcNAcylation on chondrogenic differentiation 4087 4088 4092 4089 8473 10724 PMC4832395__F4 Regulation of de novo lipogenesis by SREBP1c and ChREBP 2932 22937 355 79071 5313 2147 PMC4832581__F2 Cellular iron homeostasis and putative involvement of NBIA‐associated genes 1356 2512 23400 80025 80067 11152 80347 8398 83636 79152 PMC4834538__F7 Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis 100187907 4772 89780 PMC4835201__F10 A hypothetical diagram illustrates potential mechanisms in silicosis 2475 4615 7099 148022 8678 PMC4838842__F7 Resveratrol enhances HBV replication through activating Sirt1-PGC-1Alpha-PPARA pathway 23411 5465 1356 PMC4841025__F6 Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice 6319 5465 5914 5467 11081 5468 780896 6256 PMC4844852__F1 Environmental Exposures – The Missing Link in Immune Responses After Transplantation 405 196 7018 1543 1544 1545 PMC4848008__F2 The hedgehog (Hh) signaling pathway and FAK cooperation with NANOG and p53 in the CSC phenotype 6608 8643 5727 2735 79923 PMC4848973__F5 Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression 960 3236 387 389 331 596 PMC4849272__F3 Hepcidin antagonists 25928 7018 151176 7036 3077 148738 6774 4089 3717 PMC4859220__F3 Poor tumor T cell infiltration 1499 467 4283 3627 6351 2919 PMC4859668__F3 DDX3 is involved in Wnt/Beta-catenin pathway 1499 4040 4041 324 595 4316 607 PMC4860843__F8 Disruption of TGF-Beta-mediated tumor suppression in SCLC cells 4087 4088 4089 429 PMC4863308__F1 Hedgehog (Hh) signaling.Notes: Normal activation of the signaling pathway results from the binding of Hh ligand to the 12-transmembrane patched 1 (PTCH1) 6608 5727 51684 2735 PMC4863690__F1 Emerging treatment options for myelofibrosis: focus on pacritinib 2056 3717 3716 2475 PMC4864225__F3 Hypothesis on skeletal muscle adiponectin resistance in chronic heart failure 51094 2308 23411 PMC4865891__F6 Loss of Interleukin-21 Receptor Activation in Hypoxic Endothelial Cells Impairs Perfusion Recovery after Hindlimb Ischemia 6774 581 59067 PMC4867399__F2 Illustrated summary of Hedgehog pathway and its effetcs at different stages in the formation and progression of ductal pancreatic carcinoma 3569 6387 6608 7852 6469 5894 PMC4869267__F1 Scheme of glucose metabolism and the respiratory chain in Gluconobacter oxydans DSM2343 27343 11201 5132 PMC4871119__F1 (Adapted from Alinari, Quinion, and Blum 613 930 7852 695 PMC4872729__F2 Understanding the role of the kynurenine pathway in human breast cancer immunobiology 6999 3397 3398 8942 8564 23475 130013 PMC4875828__F1 Mechanobiology of TGFB Signaling in the Skeleton 4090 4086 387 4087 4088 6662 860 PMC4876232__F1 FGF21 induces preventive effect on CVDs through multiple signaling pathways 26291 23411 572 5465 PMC4876503__F6 Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a 3439 3454 57506 406938 6772 PMC4880855__F1 The (simplified) gene regulatory network controlling primary sex determination in placental mammals (see Additional file : Figure S1 for the more complete network) 2626 1761 6662 6736 2254 54361 PMC4880867__F1 Fzd7 receptor complexes and signalling output 6385 7474 6259 4920 7481 84133 54894 55366 1499 4041 4040 7473 51199 PMC4881529__F3 Diversity in GPCR-mediated regulation of Wnt/Beta-catenin 1499 324 2932 PMC4881570__F2 MiRNAs in cardiac fibrosis pathway 3569 6010 3716 4087 4088 6774 10252 2353 6722 1281 PMC4890987__F10 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells 2317 1019 5606 1399 10782 2353 3725 10950 50486 163 PMC4890987__F13 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells 468 4089 51176 9209 3925 10664 5569 1236 3983 PMC4891443__F5 Regulation of insulin-like growth factor 1 receptor signaling by microRNA-4458 3479 3480 4314 PMC4899241__F6 Biological function of extracellular HMGB1 is redox dependent 3146 6387 114609 PMC4905708__F2 Coinhibitory pathways in the B7-CD28 ligand-receptor family 987 941 942 324 940 3383 325 PMC4906842__F2 Steroid biosynthesis pathway 1583 412 1586 1584 1585 PMC4906927__F2 Schematic of the RBPJ structure and domains demonstrating the domain organization of RBPJ, NICD and MAM 3516 686 1283 PMC4909106__F4 Innate sensing of Toxoplasma gondii and Plasmodium sp 51284 54106 4615 57506 3665 3661 3394 PMC4910120__F4 Therapeutics in development target the IFN pathway in SLE 1773 51284 54106 3716 7297 4615 5132 PMC4910530__F1 Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD 25978 54664 29110 7415 55255 203228 PMC4911360__F11 Gene-network of not isolated genes selected by Adalnet in the TCGA ovarian dataset 9785 2766 5925 7976 324 PMC4914160__F10 Model depicting autophagy receptor recruitment to depolarized mitochondria over time 65018 8887 10133 29110 PMC4916003__F1 Natural products as TLR agonists and antagonists affecting various stages in the signaling pathway, including downstream molecules MyD88 and IKK 7189 7096 10333 7097 7099 54106 PMC4918710__F1 Alternate complement pathway 718 1675 629 3075 3426 730 729 735 7056 PMC4919024__F6 The pathway of EGF induced anticipatory UPR activation 1950 2353 1958 638 83939 PMC4925820__F4 The hunger signaling pathway constructed in the IPA program colored according to genes correlating with circulating leptin levels 5697 5914 7054 PMC4926232__F7 FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct 861 4089 2252 652 27302 PMC4928174__F1 Core Reelin signaling pathway 1398 2932 7436 1000 PMC4928174__F2 Canoncial and non-canonical Reelin signaling 1600 1020 1000 PMC4930925__F4 Gene circuits for biomedical applications 51599 1385 50616 7124 3274 6774 PMC4931664__F1 Canonical NFKB pathway (left) induced by signals including antigens, TLR ligands and cytokines such as TNF uses a wide variety of signaling adaptors to engage and activate the IKKB subunit of the IKK complex 613 958 5971 PMC4934035__F5 The pathway of LysoPC16:0 4099 4018 5091 PMC4937026__F4 Activation of STAT3 in KSHV-infected endothelial cells 966 1604 3717 6450 6774 PMC4937870__F6 Activation of IL-8 and cyclin D1: proposed POP mixture pathway shared by inflammation and cancer 196 1385 595 PMC4941333__F9 Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3B/Beta-catenin pathway 360 2932 1499 960 PMC4943391__F2 Melanocyte differentiation pathway dependent on MSHA and ACTH 4158 1385 4286 2315 7306 PMC4946436__F8 Interplay between ErbB3 and CXCR4 for the activation of Rac1 and breast cancer cell motility 3273 7852 2064 2065 5879 PMC4947825__F2 Interactions between coagulation and inflammation during IAV infection 7035 7450 3383 7412 PMC4950325__F6 Schematic representation of the metabolic pathway leading to the activation of vitamin D3 to calcitriol 5212 120227 1593 1594 1591 PMC4956099__F8 ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle 545 1643 84126 7508 472 7507 PMC4959106__F3 Nogo-B regulates de novo SL biosynthesis through the inhibition of SPT activity to control vascular tone and BP 1901 9294 124976 100271695 4841 387 PMC4961118__F1 Quantification of the input-response function of LAT:Grb2:SOS assembly in TCR signaling 2885 7535 27040 3055 PMC4961512__F8 Curcumin and PKC signaling pathway in colon cancer 1956 1958 54658 PMC4967210__F5 Ingenuity Pathways Analysis of the effects of TXNIP deletion 1026 2194 3791 10628 11060 641371 PMC4973992__F6 High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model 2744 81539 2918 2912 9463 2917 2911 2914 2916 2915 2913 PMC4977872__F9 Hypothesis of “The regulation of H3K27me3 on S 3458 567 3586 3627 PMC4979363__F6 Proposed mechanism of Hb (and its oxidized species)-induced toxicity: Hb undergoes oxidation to higher oxidation states, such as HbFe3+ and HbFe4+ 3240 3263 2147 7099 PMC4979589__F7 MUC4 is negatively regulated through the Wnt/Beta-catenin pathway via the Notch effector Hath1 in colorectal cancer 4585 324 2932 8312 1499 3280 PMC4986688__F1a Immune mediators of chronic pelvic pain syndrome 958 338376 3586 920 3565 59067 3569 3596 PMC4989102__F6 Network motifs that are coordinately regulated by the miR-17–92 cluster 7018 5613 51701 9252 5567 3727 5906 5908 6197 5922 4217 1847 11221 1849 2250 8491 57551 4214 1398 5494 5534 PMC4989114__F10 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate 8608 157506 53630 PMC4991494__F6 Quantification of mutant alleles in circulating tumor DNA can predict survival in lung cancer 3624 4089 5591 472 1387 PMC4993044__F3 Proposed sequence of events following aberrant fatty acid reabsorption at the apical surface of the proximal tubule in the setting of nephrotic syndrome 213 2180 1374 7038 PMC4994014__F5 B-cell apoptosis 6774 6772 3718 3716 PMC4997943__F2 CEACAM6 Signaling Pathway 4680 7448 6714 4088 PMC5000066__F9 Proposed model illustrating how KLHL21 modulates the NFKB signaling pathway via targeting IKKB 9903 64332 1843 2919 7128 3553 PMC5000685__F2 Diagram of LPS-induced TLR4 signaling 3929 7099 929 4615 54472 3656 51135 23118 7189 51295 PMC5003019__F8 HIV-1 Tat disrupts CX3CL1-CX3CR1 axis in microglia via the NFKB-YY1 pathway 6376 1524 7528 1378 PMC5004238__F4 Schematic illustration of axon-microglia interactions and the CASP6/p38/TNFA signaling pathway in the spinal cord dorsal horn of male rodents 839 627 7442 PMC5004872__F7 Schematic showing proposed mechanism of ECM synthesis following CDH11 engagement 1009 6010 93649 4087 4088 PMC5007117__F2 Schematic representing intrinsic and extrinsic apoptosis initiation 317 581 4170 PMC5009769__F3 Wnt pathway regulation of intestinal stem cells 4040 4041 59352 8549 55366 84133 54894 PMC5015973__F8 Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming 346673 4089 339345 4838 PMC5016670__F10 Signaling pathway by which TGFB1 increases DNMT1 and DNMT3a 7049 1788 2932 1786 PMC5022012__F3 An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population 3785 1356 3308 1173 5566 9099 367 7161 9915 2104 PMC5023675__F5 Non-canonical NFKB signaling pathway 6955 7186 5971 PMC5026795__F1 Recognition of C. albicans by pattern recognition receptors 7097 10333 7099 6850 7124 3565 3553 4118 PMC5031950__F2 PCSK9 and apoB-containing lipoproteins metabolism 255738 338 348 3949 22937 PMC5035594__F2 Anticipatory UPR Activation: A Protective Pathway and Target in Cancer 6714 1950 4803 3082 613 PMC5037286__F2 The NLRP3 inflammasome by the ubiquitin system 7099 25827 114548 79184 7186 81858 PMC5045492__F2 Depiction of the organization of the major steroid biosynthetic pathways in the adrenal cortex 6770 5447 1362 1528 6822 PMC5053480__F5 Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation 4632 477 462 1293 2335 2266 1311 1277 1303 2331 10631 5816 PMC5054393__F7 Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells 7046 3460 3717 9372 2033 6773 6772 7043 1850 11221 2475 80824 6767 5599 1846 5595 5594 1843 1847 5292 PMC5055986__F7 A probable signaling pathway of folic acid mediated modulation of inflammatory response in microglia cells 8651 9021 3603 PMC5056611__F1 SETD1A-induced miRNAs suppress gene expression modules 9739 2146 7832 PMC5058685__F7 Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway 3717 6774 3090 4313 PMC5064220__F7 Signaling network connecting RAS and mir-200 regulates apoptosis and EMT in cancer cells 3845 3725 6667 9839 6935 596 PMC5067143__F2 (Opposite and overleaf) Visualizing drug action 1950 5228 1956 6772 PMC5067249__F1 Schematic representation of the classic, alternative, and neural cholesterol clearance pathways of bile acid synthesis 1581 10858 1593 9420 51302 1582 8213 PMC5067692__F1 Newly synthesized FGFR1 can enter either the constitutive membrane pathway or regulated nuclear pathway in membrane pathway the receptor is processed and glycosylated in Golgi and accumulates in plasma membrane 4803 655 5212 PMC5069085__F1 Integration of lipid homeostasis into the macrophage host defense response 8685 7099 3553 PMC5069093__F1 Regulation of TLR folding, trafficking, and cleavage 7099 4118 4615 51311 54106 51284 81622 950 200576 PMC5069291__F1 Schematic model of the Wnt/beta-catenin pathway 4040 4041 324 2932 1499 PMC5070718__F1 Levels of miR-146a and miR-146b are regulated by innate immune signaling 7097 7098 7099 3654 7189 6774 29775 6364 6352 PMC5070917__F1 Bruton’s tyrosine kinase in autoimmunity and implications for therapy 4067 6850 695 5336 29760 PMC5073880__F4 Diagram of pathways by which AGEs affect genes involved in steroid synthesis and follicular development 4090 4086 6770 1586 PMC5076460__F6 Global gene profiling of aging lungs in Atp8b1 mutant mice 1387 4151 387 399 4634 PMC5078009__F4 Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells 4072 2475 6657 PMC5078051__F6 Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium 7849 596 7157 2305 9212 5347 PMC5079664__F1 CDK4-CDK6 protect DNMT1 from autophagy 5371 1786 1019 PMC5080294__F2 Proposed model for the targeting of NRAS-mutant melanoma by ERB ligands 4893 641 595 896 PMC5080721__F4 mRNA microarray analysis (microarray cohort; n = 36 GBMs) revealed SVZ-dependent differential gene expression of key hierarchies of the Notch pathway 3714 10683 4854 57801 55534 PMC5084660__F3 Putative molecular pathway that links GSK3B activity with the resistance of pancreatic cancer cells to DNA damage induced by gemcitabine and ionizing radiation 2932 1021 1019 1499 1788 4255 PMC5088662__F5 Schematic diagram elucidating signalling pathway of TLR4 and TLR9 responsible for GFNs-induced cytotoxicity 54106 7099 4615 7189 3553 PMC5100803__F1 Genes associated with the NRF2-mediated oxidative stress response pathway that were differentially regulated in aldosterone-producing adenoma (APA) vs zona glomerulosa (ZG) and ZG vs zona fasciculata (ZF) 5578 5583 9817 316 3726 949 2353 2940 2948 2941 PMC5102108__F7 Hypothetical model of macrophage-to-Huh7 cell transmission of TLR3-induced anti-HCV activity by exosomes 100187761 7098 29102 PMC5105987__F11 PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases 2066 51741 9542 9328 6256 3486 79158 56994 3479 50511 PMC5108588__F8 Hypothetical model explaining the dysfunctional Wnt–Beta-catenin signaling in PPARG deficiency 1869 51527 2932 8862 PMC5119679__F1 Hydrogen sulfide (H2S) regulating mesenchymal stem cell (MSC) function 162514 55503 54795 875 860 1499 9242 PMC5122694__F3 Canonical pathways by IPA: antigen presentation pathway in the NC vs 920 811 4261 3458 PMC5123862__F6 Polymerase exchange during TLS on the lagging strand 5111 1362 4827 353497 PMC5124539__F2 Role of Interleukin-18 in the Pathophysiology of Allergic Diseases 7124 50943 3596 3565 PMC5126201__F1 Adenosine pathway mediates immune suppression 100 84890 324 PMC5133678__F14 ‘Apoptotic execution phase’ gene enrichment in cisplatin-treated samples 6304 4001 63967 3146 3148 PMC5134704__F1 The plasticity of EZH2 in regulating MMP-mediated invasion pathway 8726 23512 2146 2305 PMC5138253__F5 Different roles of Gq- and Gs-coupled GPCRs expressed by AgRP neurons in food intake 770 4852 181 PMC5143318__F7 In silico analysis of Noggin interactions with other proteins 654 2626 650 652 653 8200 9241 655 657 1482 392255 PMC5144739__F1 Interleukin-10 (IL-10) gene transcription regulation 30835 7099 4615 6850 PMC5154753__F2 Pathways activated following binding of the TSLP cytokine to its receptor complex 85480 3717 3716 PMC5158012__F3 Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target 6850 4615 3717 4353 54210 PMC5161753__F5 Summary of the mechanisms for LAPTM4B promoting cancer development 1950 1956 51527 55353 4313 842 4303 4318 PMC5168844__F2 Network structure for PI3K signaling pathway in Lung Adenocarcinoma (LUAD) 7249 10018 4790 5578 5594 7531 1027 9134 4609 842 PMC5175149__F7 Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide 3716 7297 6774 4827 3454 3455 PMC5192336__F2 MUC induces inflammasome activation 10628 114548 3603 PMC5206567__F7 The locus coeruleus (LC) pathway to cortex and its involvement in stress 367 8484 2587 PMC5207000__F2 Genetically decreased vitamin D and risk of Alzheimer disease 1717 120227 2638 1594 1591 PMC5209283__F7 Stat3 and C/EBPB synergize to induce miR-21 and miR-181b expression during sepsis 6774 595 1019 PMC5217521__F2 Oncogenic mutations for the upregulation of EREG expression.Notes: Oncogenic mutations in the EGFR, KRAS, or BRAF genes result in activation of the MEK/ERK signaling pathway, which in turn upregulates EREG expression 2069 2066 3845 673 PMC5220130__F7 Schematic representation of the BCR signaling pathway demonstrating the ibrutinib sensitivity of BTK C481 variants and their impact on downstream signaling 613 6714 5336 PMC5220431__F4 The HH signaling pathway in lung cancer 6608 2925 5584 55733 6657 2736 PMC5227296__F4 Cordycepin function in chondrogenesis and chondrocyte hypertrophy of MSCs 4853 4851 26508 23462 3398 PMC5234836__F5 Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway 5610 3433 55289 8638 55601 4938 3434 10346 3959 2537 4599 3437 54739 51191 4939 5359 91543 4600 9636 3431 7039 4940 83666 2678 3665 10379 151636 8519 54625 84166 9910 PMC5239799__F1 Integration of non-genomic signaling and canonical signaling of androgen receptor (AR) 6714 367 2002 572 PMC5247472__F1 Vitamin D metabolism 1591 1594 120227 1628 5741 8074 PMC5260935__F7 Late-phase synthesis of IKBA insulates the TLR4-activated canonical NFKB pathway from noncanonical NFKB signaling in macrophages 7099 5970 4792 PMC5264260__F2 Intracellular signaling pathways of A7nAchR in anti-inflammatory response 7099 4615 51135 6774 3553 3146 PMC526469__F6 Working model for SPRR1A activation in the myocardium 3976 3977 6774 3569 6698 PMC5268776__F12 Differential Feedback Regulation of Δ4-3-Oxosteroid 5Beta-Reductase Expression by Bile Acids 1581 1582 6718 6476 PMC5270220__F1 APP cleavage pathways 351 102 8754 25825 23621 PMC5271383__F2 Regulatory mechanisms of NLRP3 inflammasome assembly 3466 79184 114548 407008 140609 PMC5272919__F2 Opportunistic intruders: how viruses orchestrate ER functions to infect cells 79982 54788 202052 6449 PMC5275772__F4 Beneficial effects of hepatic CAV‐1 on atherosclerosis protection in DKO mice 857 1593 355 7038 3949 PMC5278463__F7 Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism 11277 4280 3661 7942 PMC5280876__F3 Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Acute Lung Injury and Other Inflammatory Lung Diseases 3480 4204 3383 7412 PMC5294960__F1 Canonical and non-canonical TGFB signaling pathways 7046 4087 4088 387 9618 6885 7189 2475 4089 PMC5298971__F1 Vitamin D synthesis pathway 5212 1593 120227 1591 1594 7421 PMC5299705__F7 The regulatory network of HOTAIRM1 involved in the autophagy pathway and the degradation of PML-RARA 100506311 8408 128338 1869 PMC5309231__F3 Downstream effects analysis enables prediction of the effect of gene expression changes in each treatment 1390 2268 8837 3956 842 5579 598 5657 8743 8795 7039 7124 PMC5312381__F7 MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway 7852 387 394 PMC5320608__F10 Schematic model of TREM2 in the regulation of Beta-catenin signaling and microglial survival 89780 54209 6850 1499 595 PMC5321214__F1 Coupling of toxic and pro-inflammatory lipids and innate immune response 948 7099 4615 PMC5322168__F4 Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort 3398 85363 5287 6772 1236 3572 6402 864 6775 604 972 3458 613 920 3575 29851 50615 914 3559 969 8320 59067 3600 3565 PMC5322168__F5 Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort 3398 7535 920 3627 643 6774 29851 6402 1236 25939 864 3572 4772 6095 814 6775 7852 59067 50943 3458 1846 50615 1000 3399 PMC5328971__F3 Gamma-aminobutyric acid signaling pathway 627 2555 2559 3360 2560 2564 9568 6558 3356 11337 5334 23228 468 PMC5331050__F3 Toll-like receptor signaling pathway 4615 7189 7096 3553 7097 10333 51311 51284 7099 958 54106 7100 7098 7187 29110 3661 PMC5332279__F5 Schematic model of the TRIM8‐PIAS3‐STAT3 pathway that regulates glioblastoma stemness 10401 6774 6657 81603 PMC5335504__F9 Proposed model for the role of ADAP2 in antiviral response 7187 3661 57506 29110 55803 PMC5335555__F6 CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGFB signaling 6714 4087 4088 639 63978 6657 PMC5336494__F2 Diagram of signaling pathways that control Notch expression in PC 3491 444 1956 5310 PMC5343350__F7 Potential mechanisms involved in T helper type 17 (Th17) differentiation under T‐bet over‐expression conditions 3458 861 196 3662 PMC5343808__F2 Wnt Pathway: In the presence of Wnt ligands, Dsh blocks the Beta-catenin destruction complex consisting of Axin, APC, CK1, GSK3B 1499 2932 324 4316 4609 595 4760 PMC5343833__F6 Involvement of TGFB/Smad pathway in AA-induced fibrogenesis 4092 4280 4088 PMC5343994__F1 Mutation in the von Hippel–Lindau gene (VHL) induces loss (red ×: HIF-2a is no longer inhibited) of the regulatory tumour suppressor p-VHL and catalyses the “von Hippel–Lindau-hypoxia-inducible factor” VHL-HIF pathway 7175 7428 5155 7039 PMC5345336__F4 Notch signaling pathway 54567 10683 28514 3714 182 PMC5346035__F1 PharmGKB summary: macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics 1244 5243 1576 10599 28234 5004 PMC5346417__F5 Diagram showing the hypothetical model for regulation of NCC phosphorylation in the DCT cell, and hence the level of transcellular NaCl flux 3766 65266 1638 PMC5346543__F9 Diagrammatic presentation of the mechanism of EMAP-II in combination with TMZ suppressed malignant biological behaviors of GSCs via miR-590-3p/MACC1 inhibiting PI3K/AKT/mTOR signaling pathway 3479 346389 2475 PMC5348403__F4 Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway 1856 3672 5328 4318 3673 4162 3690 3675 5155 7422 PMC5354081__F1 Examples of Metabolic Pathway Linking Gut Microbiota to Cardiovascular Diseases 948 114548 1581 1593 PMC5355309__F10 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis 7099 2932 9023 PMC5355421__F1 Schematic illustration representing the microglial intracellular Ca2+signaling mediated by canonical transient receptor potential 3 (TRPC3) channels and the tripartite synapse 627 3458 7222 6786 PMC5355638__F2 Mechanisms of RSV T-cell interference as a potential immune evasion strategy 920 355 2475 PMC5355992__F9 Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo 7099 4615 7189 PMC5356579__F2 Somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy 27121 22943 27123 27122 7046 7048 4041 92 11211 324 4088 8313 4087 4089 1499 6934 55294 8289 6662 4609 6932 3481 472 2065 2064 3480 8660 3845 5728 673 PMC5357773__F5 FcGRIIIb initiates signaling pathways to the nucleus 6714 6850 2002 PMC5362574__F8 Suggested model 3458 27035 6714 6772 7018 PMC5364998__F2 Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter? 5879 3146 7097 54106 PMC5365005__F6 Sclareolide pathway enhances gemcitabine-induced gemcitabine-resistant human pancreatic cancer cell death 2735 6240 7291 PMC5367255__F8 Model depicting role of miR-432 in regulating myogenesis 1871 2475 4656 PMC5372284__F4 Phospho-sites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT signaling pathway in a lung adenocarcinoma cell line harboring a L858R mutation in the kinase domain of EGFR, which is reactive to treatment with erlotinib 1950 2885 57521 1977 PMC5372786__F1 Pathway for synthesis of ceramide, sphingomyelin, and sphingosine-1 phosphate 53637 1901 9294 1903 8698 PMC5374583__F7 Survival and proliferative effects of AOF extract on RSC96 Schwann cell 3479 3480 595 572 PMC5382109__F3 Apoptotic pathways of NFKB: TRAIL mediating the extrinsic pathway and p53 mediating the intrinsic pathway 581 317 5970 PMC5387898__F2 Simplified schematic of the possible mechanism of lymphangiogenesis in cancer cell metastasis 6469 7424 11117 PMC5391049__F1 Wnt Signaling and Colorectal Cancer 64840 79971 54894 55366 8549 59352 80351 1499 324 2932 8313 4609 PMC5393948__F6 Isl1 conditional mutants are deficient in Foxo signaling 3670 100132074 2309 60468 2308 PMC5394116__F1 Although a myriad of intracellular signaling is involved in passive therapies, their pathways show some overlap 7852 940 1493 2475 PMC5394902__F2 Canonical pathway and upstream regulator effects analysis identifies inflammatory response, migration, and proliferation pathways enriched in trkB.T1 KO astrocytes 5468 7124 5743 629 3684 718 PMC5394985__F1 Interluekin-17A (IL17A) 920 3603 6095 6097 6774 2919 3576 6347 PMC5397778__F3 Helicobacter pylori-induced chronic inflammatory and neoplastic diseases 6469 1045 3458 9242 PMC5399176__F8 Proposed mechanism for ion flux-dependent regulation of the NLRP3 inflammasome 3553 114548 8011 PMC5400646__F8 Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway 5155 1509 811 6277 1977 25824 5159 PMC5403977__F12 EGF and GLP-2 signaling to attenuate mucosal atrophy in a mouse TPN model 1950 595 9340 3479 PMC5405080__F11 Reactive oxygen species (ROS) maintenance by redox homeostasis 472 57103 355 PMC5407765__F9 IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria 4283 3627 90865 6761 PMC5408006__F3 Toll-like receptor signaling pathways 7096 7097 10333 81793 7099 7098 4615 51284 54106 51135 7187 4790 3661 3665 PMC5410752__F1 Schema of the migratory modes of the excitatory neurons during neocortical development and molecular mechanisms downstream of Reelin signaling that control neuronal migration 1000 1356 4150 PMC5411693__F6 Hypothesized altered feedback control of the POMC gene promoter in cells having USP8 or RASD1 mutations (mut) versus wild type (wt) 51655 9101 1392 1956 5443 PMC5414761__F8 Proposed mechanism for GDNF-induced proliferation of mesenchymal and epithelial cells in the UGS 2668 2674 5979 PMC5416999__F11 Signaling mechanisms for PGF2A and AL-8810 stimulation of FP receptor 1950 1956 1839 6714 PMC5423134__F9 Proposed mechanism of action by the combination of VCP inhibitors and ER stress‐prolonging agent Salubrinal 7415 83939 468 PMC5430039__F4 Host miRNAs that favor viral replication via the inhibition of the Jak/STAT signaling pathway 3716 407021 442918 10379 PMC5435970__F7 Model depicting the mechanisms by which TIEG1 modulates canonical Wnt pathway activity in osteoblasts 4041 4040 2932 324 51176 PMC5440471__F3 Manipulation strategies of neutrophils and the immune system by P 7124 3553 7097 3603 PMC5444348__F1 The IFN-1 > BID > ROS pathway connects DNA damage with hyper-proliferation and malfunction of haematopoietic stem/progenitor cells (HSPCs) 115004 3661 545 472 637 23788 PMC5445144__F4 Regulatory T cell (Treg) action mechanisms 1493 942 941 3902 637 PMC5448443__F1 Amyloidogenic and non-amyloidogenic processing of the APP 351 23621 2827 3579 4803 1950 PMC5451507__F2 Congenital heart defect BioCore (CHD-BioCore): strategy and frame work 5728 5228 1956 6714 55364 51527 PMC5466034__F10 A Putative Model of Central Carbon and Energy Metabolism in Tomato GTs.A type VI glandular cell with its plasma membrane as a black line 3652 729 4118 11113 PMC5468621__F5 Summary of signaling events and downstream transcription factors driving specification of the blood stem cell lineage 2116 3087 2624 4851 PMC5474130__F2 Oxysterols in human cancer 19 5243 22937 5007 PMC5477782__F8 The haptoglobin beta subunit sequesters HMGB1 toxicity in sterile and infectious inflammation 3146 3240 9332 PMC5481559__F14 Proposed model for persistent fibrosis in mice after lung injury 3373 8372 3037 50507 4088 PMC5482989__F7 Proposed mechanisms for crosstalk between AR and GDNF signaling and inhibition of prostate development by RET-mediated GDNF signaling 2674 2668 367 5979 PMC5484415__F5 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy 2805 2806 4199 PMC5485730__F2 Interferon (IFN) type 1 signaling; regulation by methylation 3454 3455 7297 3716 23210 6773 6772 3276 8554 10379 PMC5490578__F7 Simplified diagram of the lipid metabolism canonical pathway 7038 348 347 5444 3931 5360 53369 1071 PMC5493720__F2 Changes in the methylation state of parentally imprinted genes lead to attenuation of GH/INS/IGF signaling in VSELs 3479 3481 3630 100033819 283120 PMC5494974__F5 Haploinsufficient tumor suppressor genes 4092 2309 7248 7249 4087 64750 57154 4089 6497 PMC5496266__F2 The roles of microRNA families in hepatic fibrosis 56034 3479 10000 4015 9759 PMC5499621__F10 The scheme for target of 4-O-Methylhonokiol on the TGFB pathway 4087 4088 4089 6667 50507 PMC5500819__F1 Schematic depiction of the strategy employed for mining the O-Man glycoproteome in cell lines with knock-out of COSMC, POMGNT1, POMT1, and POMT2 84892 10585 29954 4249 55624 4397 PMC5503519__F9 Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells 3597 3716 6778 2625 27035 896 PMC5503659__F3 Roles of long noncoding RNAs in colorectal cancer metastasis 283120 100033819 9775 4609 1499 960 5728 100505592 57403 596 6934 101805488 255082 3190 PMC5512074__F6 Schematic overview of p90RSK-mediated regulation of UBR5-containing miRISC 1656 51366 7187 29110 PMC5514694__F9 Coordinating reactions in the intestine elicited by LGG in response to S 6364 1235 4023 3458 6774 920 PMC5517452__F7 A putative signaling pathway of parkin expression induced by MIDN 4803 90007 468 5071 PMC5520418__F2 PTEN functions in T-cell development, activation and differentiation 5728 920 324 PMC5523860__F7 HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development 6615 3037 7291 3182 4487 6662 9464 PMC5524151__F1 BDNF signaling is a balance between proBDNF/p75NTR and BDNF in glial cells or inhibit phosphorylation of FL-TrkB thereby preventing stimulation of survival, growth, and neuroplasticity 5340 627 2321 PMC5524517__F1 Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia 9493 8519 2149 4125 4323 4072 4318 1277 5328 9075 7076 1113 7412 633 4609 1462 1499 1366 6774 9601 1281 29851 9343 3383 5159 1116 5329 1051 871 7037 6678 PMC5526760__F5 Summary of gene function and epistatic interaction of the IL-10/STAT3 signaling pathway in pediatric inflammatory bowel disease 3586 3587 3588 3716 7297 6774 PMC5528312__F2 RNF8‐ and RNF168‐dependent ubiquitin signaling pathway at DSBs is stimulated by CHD4‐ and p400‐mediated chromatin remodeling 472 9025 9656 1108 672 165918 PMC5531310__F3 Glycolysis is downregulated in idiopathic pulmonary fibrosis (IPF) lungs, with possible shuttling of intermediates to the sorbitol and pentose phosphate pathways 56731 92579 5209 5223 PMC5531360__F3 Possible interactions between signaling molecules 2056 7450 2247 387 PMC5540157__F1 The Shh signaling pathway 6469 6608 5727 891 6714 51684 PMC5544725__F7 Role of 1,25(OH)2D3 in myofibroblast differentiation and extracellular matrix deposition in TGFB1-induced nasal polyp-derived fibroblasts and nasal ex vivo organ culture 4087 4088 7421 PMC5548025__F7 A model of mTOR signaling pathways involved in AS 2475 23411 19 1236 PMC5549304__F6 H3K79 methylation pathway and potential therapeutic targets 23476 56254 51322 9810 PMC5549368__F1 Checkpoint inhibitors in melanoma and early phase development in solid tumors 673 920 1493 PMC5550896__F1 TGFB family member signaling and its target in CRC 7046 7048 659 92 657 93 91 658 130399 4090 4086 PMC5559228__F4 Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways 2475 96459 10113 PMC5563468__F5 Regulation of the ROCK/MRTF/SRF pathway in fibroblasts 4018 387 6722 PMC5563989__F2 The apoptosis regulatory network under ER stress 637 83939 468 PMC5564764__F7 BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways 660 6774 2475 4827 PMC5564844__F4 Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer 1956 283120 652995 6774 5728 PMC5571607__F2 DAMP/ TLR/ inflammasome interactions 3146 84890 7097 7099 960 114609 4615 3656 3654 7189 114548 3665 3661 PMC5574038__F6 The role of the Dishevelled DEP domain in Wnt/Beta-catenin signal transduction 89780 1499 4040 PMC5575202__F5 Significant association of the 97 gene signature with transcription factors TP53 and HIF1A 7058 10512 5328 2252 7057 7078 3490 3624 7857 3479 5156 1825 3783 56937 5159 23022 1410 59 3091 2353 9770 1959 1843 3164 PMC5576693__F4 Study on molecular mechanism of ANOS1 promoting development of colorectal cancer 6424 27123 857 51339 144165 1601 4920 6422 6423 115908 51176 8321 64750 7531 3730 PMC5576943__F2 Complement activation pathways and allograft immunity 5648 324 727 718 1380 920 716 PMC5578700__F1 Bon EPOtit! S1P-Mediated EPO Signaling Whets a Macrophage’s Appetite for Apoptotic Cells 2056 2057 4240 10461 948 2621 PMC5579367__F1 Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis 115004 81030 197259 8737 11035 PMC5583221__F1 Mechanism of axon degeneration and sites of action of chemotherapeutic drugs 331 23057 4803 23098 64802 PMC5587804__F4 Differential metaMIR analysis recovers miRNAs involved in cancer 27022 4763 7157 5728 26038 27086 4771 9241 650 657 4086 652 659 655 7046 7040 4087 7048 4089 4609 7042 4088 7049 7043 PMC5588661__F1 Action of metformin on cancer 7249 7248 2475 2194 3479 3486 PMC5590227__F1 The STAT3 pathway and therapeutic targets 6774 1957 1950 1956 6714 595 4609 5802 PMC5593690__F2 The PI3K/Akt pathway: a critical player in intervertebral disc degeneration 2475 595 6662 2932 3712 PMC5596246__F3 Caspases control the cGAS-STING signaling pathway 581 115004 29110 3661 6778 PMC5597599__F13 Computational modeling framework 1950 9021 1432 PMC5600869__F4 Active DNA demethylation pathway 1789 1788 1786 23583 6996 8930 PMC5601168__F1 Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy 2932 324 1499 4040 4041 PMC5602294__F1 Biosynthetic pathway of NAD+ production starting from Na 93100 64802 349565 55191 PMC5608693__F6 Model of step-wise progression in DPN-like melanoma 673 1499 324 1029 7015 7157 8289 54790 PMC5609334__F1 NF-kB pathway 613 355 10913 PMC5609950__F9 Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma 10637 331 581 596 PMC5610669__F3 Examples of IGF-targeted agents 3479 3481 3480 PMC5612509__F1 Complement-mediated haemolysis in chronic cold agglutinin disease and cold agglutinin syndrome 717 718 727 PMC5615985__F6 Role of the LGM2605 in preventing asbestos-induced inflammation, oxidative/nitrosative cell damage, cell injury, and cell death proposed mechanism of asbestos-induced inflammation and oxidative/nitrosative stress and the protective effect of LGM2605 114548 3603 3146 7124 3569 PMC5618569__F2 Schematic representation of the cytoplasmic and nuclear functions of the autophagy—related factors Beclin-1, LC3B and p62 5371 2475 165918 PMC5618627__F2 HSP27 mediated suppression of apoptosis promotes tumorigenesis 9261 7867 355 PMC5621755__F1 Schematic illustration of the repression of the canonical AhR signaling pathway by AhRR 196 57491 405 PMC5623854__F1 CD95L is a chemoattractant for inflammatory T cells and triple-negative breast cancer (TNBC) cells 4314 4316 102 1956 PMC5626616__F1 TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines 324 939 50943 596 PMC5628280__F1 Signal transduction by flagellin in mammalian cells 7100 7099 7189 58484 3603 3553 6364 PMC5630004__F1 Context-dependent transforming growth factor B (TGFB) signaling outputs arise from pathway interactions 7124 7039 1950 4088 4089 7018 PMC5630306__F7 Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL 3567 3568 3717 4067 4155 PMC5632571__F1 Transcriptional regulation of Th9 cell generation 324 940 10538 3662 2625 941 942 PMC5632899__F1 Schematic diagram of an IL-33 signaling pathway 90865 6761 4615 7189 PMC5642637__F2 miR-708-5p: a microRNA with emerging roles in cancer 960 3840 4826 PMC5642919__F5 Proposed model 27179 4087 4088 4089 PMC5645057__F1 TGFB signaling pathway in prostate cancer cells 7049 4087 4088 4089 4092 4091 367 PMC5645611__F1 One marker is not enough for designate one cell as cancer stem cell 1499 4072 100133941 960 PMC5649056__F3 Canonical Wnt signaling and bone remodeling 4041 4040 1499 PMC5650067__F9 Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells 4312 1956 6714 PMC5650339__F8 miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3B/Beta-catenin signaling pathway 27161 84133 2932 1499 PMC5652672__F3 Somatic mutations in salivary duct carcinoma and potential therapeutic targets 2064 5290 5728 2475 PMC5652951__F8 Schematic diagram of the role of IL-33 in the regulation of the biological behavior of glioma cells 90865 6761 4313 4318 PMC5654621__F1 Endosomal traffic jams represent a pathogenic hub and therapeutic target in Alzheimer’s disease 351 23621 8301 6653 274 PMC5655777__F2 This schematic diagram depicts the signaling pathways that possibly drive BAVM pathology 4087 4088 4089 PMC5658094__F6 Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury 7099 7808 4615 PMC5658785__F4 Roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease 3553 6285 4313 PMC5663306__F1 Bile acid metabolism and signaling in liver disease and therapy 1593 1581 9420 1582 4280 PMC5664350__F4 Summary of intracellular TLR4 signalling in platelets 114609 4615 51135 3656 3654 7189 2638 7187 3661 7099 PMC5664959__F2 Molecularly Targeted Therapies for p53-mutant Cancers 2475 4651 1956 387 PMC5665664__F6 Regulatory model of ATX expression in adipose tissue and the biological functions of adipocyte-derived ATX in diet-induced obesity 4018 6774 3976 PMC5666637__F3 Summary of the bone morphogenetic protein (BMP) and growth and differentiation factor (GDF) signaling pathway and mutations causing connective tissue and skeletal disorders 4090 4086 50964 860 4040 4041 PMC5666637__F5 Transforming growth factor B (TGFB) and bone morphogenetic protein (BMP) signaling in bone homeostasis 100187761 50964 860 4318 4313 PMC5668305__F7 The pain related mechanisms of Notch1 and TLR4 signaling pathway 4851 7099 3280 PMC5669051__F1 Endocannabinoid System in Neurodegenerative Disorders 5894 2002 627 5080 23237 PMC5671379__F1 Damage Associated Molecular Patterns in the Pathogenesis of Osteoarthritis: Potentially Novel Therapeutic Targets 3146 6279 6280 7189 PMC5671973__F1 Recognition of human immunodeficiency virus 1 (HIV-1) by innate immune system 920 51284 7098 57506 4615 3665 3661 7189 PMC5674948__F5 Summary of age, BMI, and differential correlation results (a) BMI and age independently increase inflammation in adjacent normal tissue (arrow) 1634 3866 2252 2625 2191 PMC5677537__F1 Ethanol upregulates TNFA in Kupffle cells via the activation of multiple pathways Ethanol administration activates the TLR4 pathway, ROS production and complement activation to increase the expression of TNFA 7099 718 727 29110 7189 3661 1958 114609 4615 3654 PMC5677954__F6 Osteoblastic differentiation-related molecular mechanism under combined cytokine treatment 3479 650 4090 4086 5728 2475 1499 860 PMC5681992__F1 Schematic representation of bile acid synthesis pathways in humans 1593 10858 1581 9420 1582 51302 25801 PMC5685775__F2 Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis 4090 4087 4092 4089 4088 324 1499 4040 4041 PMC5685775__F4 Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis 1499 2932 5728 PMC5685854__F7 Pathway of VEGFR-2 (produced using the Pathway Builder Tool) 7422 7424 6714 5829 PMC5686050__F1 Interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor complexes 3717 3718 5266 3598 3597 PMC5686346__F8 Proposed model of miR-130a mediated dysregulation of mTOR pathway in HGSOC 7249 2475 7248 PMC5686720__F11 Work model for NLRX1-mediated MAVS degradation during viral infection 57506 5094 79671 29110 3661 PMC5690305__F1 Simplified metabolic pathway of thiopurines 7172 8833 5879 7038 PMC5690809__F7 Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding 7862 7994 8805 5290 PMC5695831__F10 Schematic of pathways for transcriptional activation of Forkhead box protein O1 (FOXO1) and IGF-1 in the mouse liver 10554 2308 3484 2690 3717 6777 3479 PMC5700087__F8 The proposed mechanism of BBB disruption in CNS TB 2735 2736 6608 57758 6469 PMC5702855__F2 Multiple signaling pathways drive EMT in GBC cells 6469 6608 960 100133941 2475 2932 324 4088 1499 25792 2735 11197 PMC5707529__F2 Schematic representation of the HIV-1 life cycle 10955 684 135892 25939 91607 3167 PMC5711269__F1 Reverse cholesterol transport pathway 19 3949 9619 PMC5713364__F7 Analysis of the interconnection between AKAP12 and the merged networks of related joint diseases and functions 2006 9509 5973 PMC5713369__F5 Proposed mechanism whereby SM70EE ameliorates learning and memory impairments in mice with an intracerebroventricular injection of amyloidB 1–42 (AB1–42) 627 351 23621 PMC5713689__F3 Signal pathway of the immune inhibitory receptors.Notes: PD-1 crosslinks the TCR and recruits the SHP-2, which can dephosphorylate the ZAP-70 to prevent the SLP-76 and LAT from being phosphorylated 201633 3902 3932 7535 50943 27040 10125 5728 7189 2475 PMC5721794__F18 Working hypothesis regarding the mechanism by which SDF‐1A (stromal cell‐derived factor 1A) stimulates cell proliferation 7852 1803 6714 595 PMC5722516__F7 Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis 3717 2475 57650 494324 PMC5722548__F1 CYP19A1 polymorphisms associated with coronary artery disease and circulating sex hormone levels in a Chinese population 1586 6817 3283 1588 1543 1544 1312 1545 3292 54658 6783 PMC5722817__F9 Two HEB-dependent pathways of GDT17 cell development 100133941 3458 3399 6659 PMC5726210__F3 The vitamin K cycle 4256 2621 2922 2717 PMC5726781__F4 MELK promotes melanoma growth by stimulating the NFKB pathway 4397 92140 8878 9611 9612 3065 3066 8841 26574 PMC5726781__F7 MELK promotes melanoma growth by stimulating the NFKB pathway 673 4893 4763 8878 9833 1869 PMC5727250__F3 Possible Wnt pathway‐related therapeutic targets in CLL 1499 51176 4919 PMC5727324__F6 DKK1–CKAP4 axis as a novel molecular target for cancer therapy and future perspectives 27121 27122 27123 22943 10970 51201 PMC5731654__F2 Impact of BRAFi on T cell response to melanomas 673 4286 7306 PMC5732750__F6 CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer 6667 80319 9518 PMC5732848__F1 Environment Matters: Microglia Function and Dysfunction in a Changing World 54209 718 627 3479 4803 PMC5733023__F9 A schematic depicting the role of TLR4-NFkB-Caspase-11 signaling pathway in METH-induced astrocyte-related neuroinflammation 3603 114609 4615 114548 51135 7099 PMC5733031__F2 Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram positive bacteria 4049 7096 7097 4118 8651 51135 4615 9021 PMC5737940__F2 Cellular signaling pathways through which NELL-1 works 4745 2737 2736 324 2932 6608 1499 2735 860 4040 4041 PMC5739664__F7 Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling 1325 57506 29110 3661 PMC5740974__F3 Cell entry and innate immune response 51284 51311 4615 3661 PMC5743757__F1 Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets 3929 929 114609 7098 7097 10333 7100 7099 51284 51311 54106 PMC5752241__F6 The WNT signaling pathway activated by PRP 4040 4041 22943 2932 324 4772 1499 595 PMC5754244__F7 MUC1-C INDUCES PD-L1 AND IMMUNE EVASION IN TRIPLE-NEGATIVE BREAST CANCER 4609 648 6935 PMC5759028__F8 KRAS/TGFB/p15Ink4b pathway controls the cell fate 1958 3845 7040 5925 PMC5766282__F12 Novel Role of the Nociceptin System as a Regulator of Glutamate Transporter Expression in Developing Astrocytes 3718 3717 2475 PMC5769965__F10 Cocaine and HIV-1 Tat Disrupt Cholesterol Homeostasis in Astrocytes: Implications for HIV-Associated Neurocognitive Disorders in Cocaine User Patients 19 348 3949 PMC5770815__F1 Kynurenic acid (KYNA) synthesis along the kynurenine pathway and its mode of action 169355 8942 196 2859 PMC5772763__F1 Aneuploid cell survival relies upon sphingolipid homeostasis 7357 166929 259230 PMC5776175__F9 Model for Brucella Omp25 modulation of tumor necrosis factor (TNF)A suppression in porcine and murine macrophages 4615 7189 7099 PMC5782799__F5 Gene interaction network 26009 3565 7316 7704 5763 890 54503 PMC5787447__F2 Current research on head and neck cancer-associated long noncoding RNAs 100124700 283120 157273 1786 2539 1021 2146 5728 1019 PMC5787447__F3 Current research on head and neck cancer-associated long noncoding RNAs 5820 100885775 283131 2146 648 7253 1026 1499 8826 100996569 750 PMC5788151__F6 Illustrating diagram for several growth factors and signaling molecules that regulate different stages of satellite cells 5081 4617 3082 PMC5790442__F9 Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells 9817 1728 4094 PMC5790481__F13 Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling 4199 3146 7097 7099 4615 4118 3553 929 3606 PMC5790772__F1 Heparan sulfate proteoglycan (HSPG) protein family organization and HS biosynthesis 6395 717 2131 727 PMC5795664__F4 Mutations in various genes in the JAK/STAT pathway (MPL, CRLF2, JAK1, JAK3, JAK2, LNK, SOCS1, STAT3) implicated in hematologic malignancies 4352 64109 3716 3717 8651 3718 6774 PMC5796148__F1 Change in the metabolism of adenosine signaling between the states of healthy and infected 2821 24145 100 PMC5799234__F1 C-type lectin receptor (CLR) signaling in fungal recognition 7099 7097 4615 6850 5923 5894 64170 8915 114548 3661 10892 3553 PMC5803335__F3 Cytoplasmic APC and the WNT signaling pathway 1499 2932 324 8549 PMC5803787__F7 Model for the fate decision of XY PGCs regulated by stage-specific FGF9 levels 2254 339345 346673 PMC5805701__F10 An atypical IL-6-Stat3-RFX1-IL-17A regulatory pathway in CD4+ T cells of SLE patients 6774 5989 3065 1786 10873 3605 PMC5807041__F12 Significantly deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder and developmental disorder induced by Caki-2 cells defined by Ingenuity Pathway Analysis 4588 285598 353219 2913 9283 1137 147372 7037 3268 2766 27141 100422952 58480 387758 80232 93323 85474 51351 PMC5807852__F7 RHBDD1 promotes metastasis in colorectal cancer 84236 1499 6935 PMC5808968__F1 KEGG database illustration of the MAP kinase pathway 4803 627 1950 1956 PMC5815310__F3 Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease 50507 2475 23410 952 PMC5819906__F7 miRNA-gene network contains six miRNAs and their target genes, which are involved in the insulin signaling pathway 5295 10000 2932 5170 3099 5602 5290 8503 2885 5255 3635 3845 10891 868 6517 673 PMC5819921__F4 Bioinformatics prediction of genes interacting with RAC1 using Ingenuity Pathway Analysis 3909 3914 22798 5879 572 1496 7184 54361 4117 332 841 7849 PMC5821995__F3 Macrophage polarization in type 2 diabetes 4092 894 595 1499 5316 3603 472 3553 PMC5823444__F8 Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen 4280 1103 3553 PMC5825082__F7 Dysregulation of the IFN-Gamma-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia 3717 3716 6772 6774 3659 8651 PMC5825871__F9 Role of Gpr161 in forelimb initiation, limb patterning and skeletal morphogenesis 6469 23432 2255 6910 2737 3549 860 5727 100188864 PMC5827181__F1 The waves of MALT1 activation 84433 10892 7189 8915 PMC5828779__F5 Toll-like receptor signaling pathways in the prefrontal cortex 7097 7099 929 7098 51135 3654 7189 51284 7187 29110 3661 3665 3627 4615 PMC5831796__F4 GLI1-expressing hair follicle stem cells and their roles 947 8549 2735 PMC5831797__F2 Schematic depiction of the cross-talk between Hh signaling and DYRK kinases 1859 9149 5727 2736 4118 2735 2737 6608 8445 PMC5833072__F11 Schematic view of the potential mechanisms by which RNS60 protect motor neurons and ameliorate the neuromuscular impairment in ALS 50943 920 2670 4155 PMC5833436__F8 miR-146a-5p and TLR4 signaling 4615 7189 3654 4087 7099 PMC5833552__F1 Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation 613 958 941 942 940 54106 3553 7097 7099 PMC5835061__F1 Schematic presentation of synthesis and maturation of BDNF 627 5045 4313 4318 5340 PMC5835104__F2 The RT2 Profiler Array gene expression data using Ingenuity Pathway Analysis (IPA) software 3725 1437 6772 4599 64135 7098 6352 3553 51284 3659 6351 4792 10333 7189 PMC5835171__F1 INNATE IMMUNE CONTROL OF ALPHAVIRUS INFECTION 10410 9636 3434 4940 64761 6041 84875 PMC5836077__F7 Concerted agrin and YAP activity in the maintenance of NMJs and promoting cardiac regeneration 4038 4593 847 PMC5836190__F3 Activation of the NLRP3 inflammasome in the canonical pathway 3603 140609 114548 PMC5839390__F6 NFAT-mediated defects in erythropoiesis cause anemia in Il2−/− mice 2056 2057 4772 10661 PMC5840201__F1 Neurosteroid synthesis in the retina 1593 10858 1583 1589 1586 1588 PMC5845716__F1 TANK-binding kinase 1 (TBK1) in humoral responses 2638 29851 7099 29110 115004 57506 7098 10133 3661 PMC5849426__F7 Putative model illustrating the interplay between RANK/NFKB-dependent and Hdac3-dependent control of mTEC development 25833 26298 6689 55079 8841 7006 100124696 5075 2034 4781 PMC5854933__F1 WNT pathway 4040 4041 8324 22943 10075 51741 51339 92162 2932 324 1045 1499 23043 PMC5857625__F7 Schematic representation of murine and human gonadal androgen synthesis 6770 1583 1586 5447 8630 PMC5858934__F4 Model for RHO/ROCK-dependent regulation of trophectoderm-lineage specification 4771 6010 154796 PMC5861197__F3 Paradigm of host inflammation responses to Salmonella and its interaction with autophagy as well as ubiquitination 4615 7189 7187 3553 91662 PMC5862044__F1 Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence 2475 3091 4609 7054 PMC5863198__F1 All roads lead to Rome: vascular inflammation 335 1071 114548 3553 5879 7429 PMC5866434__F2 Effect of CO on cellular inflammation pathways 7099 114548 7429 PMC5866970__F2 Regulation of the Hippo pathway in endothelial cells 6010 3383 7412 27063 PMC5871897__F3 Aberrancies of the Wnt/Beta-catenin and RAS-ERK pathways and their cooperation in the tumorigenesis 1956 4040 4041 2885 2932 324 1499 PMC5871897__F4 Wnt/Beta-catenin and RAS-ERK pathway crosstalk 4040 4041 324 2932 1950 2885 1956 1499 PMC5871976__F1 Moloney-murine leukemia virus (PIM) kinases regulate cancerous pathways 3717 7852 2932 4193 993 995 572 4609 4602 2475 PMC5876639__F2 Cellular senescence pathway activated by NPM-ALK 238 6774 1021 1019 PMC5876660__F3 KSHV regulation of the TLR signaling pathway 7099 51311 51284 4615 54106 7187 3654 10010 29110 7189 3661 PMC5877513__F3 An overview of resveratrol-mediated targeting of multiple signaling pathways 4040 4041 324 51547 4089 4087 4088 1499 104472713 51129 3576 2932 PMC5877576__F11 EGFR multimerization and signaling, illustrating how carbohydrate-binding proteins or carbohydrate-transferases can directly affect transmembrane receptor signal transduction 4582 1950 1956 PMC5880643__F1 Peripheral complement interactions with amyloid B peptide (AB) in Alzheimer’s disease: 1. Erythrocyte clearance of AB 718 721 720 716 PMC5882022__F1 The regulatory roles of different sirtuins in the reprogramming of human skin fibroblasts to generate induced pluripotent stem cells 23409 6774 3976 51547 23408 23410 349565 768218 51548 23411 22933 406985 PMC5883129__F1 Ubiquitin cascade 57162 55223 7189 PMC5884684__F1 Connections between circadian cycles, C/EBPs and the NAD+-Sirt1 pathway may affect G-CSF induced granulopoiesis 9575 406 23411 1050 PMC5887474__F3 Canonical p53 DNA damage response pathway 1026 1647 5111 6790 5347 891 PMC5888214__F4 The SREBP pathway regulates cellular cholesterol metabolism 3156 22937 4864 3949 3638 PMC5889750__F7 In zebrafish following FL exposure, the most significantly modulated pathway in skin is the oncostatin M pathway 5008 2885 2002 4314 2034 4502 4322 PMC5891205__F9 Radioresistance is associated with G2/M arrest and repression of apoptosis pathway by upregulation of Bcl‐XL, Bcl‐2 and CyclinB1/CDK1 and downregulation of p53, p21, Bax, Caspase‐3 and cleaved PARP in colorectal cancer (CRC) 5930 581 891 PMC5892988__F3 Roles of the BMP system in steroidogenesis and mitogenesis in growing follicles 9210 654 2492 650 655 6770 PMC5896366__F2 EGF receptor (EGFR) effects on ABC transporters 1950 1956 5728 9429 10257 5243 PMC5899030__F3 multiple neuropeptides and receptors regulate the activity of neurons in feeding circuits 4852 181 10888 29909 4160 5443 5091 PMC5902028__F2 TIGIT pathway 324 10666 201633 10225 3932 2534 2885 PMC5904130__F5 Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist 627 6009 2475 PMC5908886__F4 Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/Beta-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis 1499 324 4040 4041 PMC5911630__F7 The role of ACSS3 as a prognosis biosignature of GCa 1431 79611 4598 6309 3949 25801 PMC5912981__F1 GCN5L1/BLOS1 links acetylation, organelle remodeling and metabolism 7942 201456 157739 PMC5916355__F5 Proposed model for nicotine-induced synaptic plasticity in the OFC 2066 23621 10718 PMC5916949__F6 A schematic depicting the potential involvement of MALAT1 in regulating inflammation through epigenetic mechanisms in diabetic retinopathy 23512 8726 2146 378938 PMC5919979__F2 Proliferation-associated lncRNAs act as p53 regulators or effectors by activating or inhibiting the p53 signaling pathway 283120 728655 441951 55384 PMC5922385__F8 Model of miR-652-mediated mechanism of EMT in PC3 cells 724022 367 6935 PMC5924546__F3 Wnt signaling pathway regulates deiodinases 4041 4040 1499 PMC5925455__F7 Hypothetical model for the aggravation of autoimmune response in Pdmx-associated and spontaneous NT1.The immune response in NT1 is highly heterogenic with different pathways affected during the disease progression 7124 3458 920 1512 1786 5032 PMC5928437__F9 miR-103/107 promoted ER stress-mediated apoptosis via the Wnt3a/Beta-catenin /ATF6 pathway in preadipocytes 89780 22926 1499 596 PMC5929164__F5 Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis 4771 4738 26524 9113 PMC5934344__F2 Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy 7474 23002 387 PMC5935119__F2 Genetics of coronary artery disease: discovery, biology and clinical translation 27329 4023 51129 PMC5938036__F2 The metabolites generated from alternative vitamin D metabolic pathway 1594 1591 1583 7421 1593 6095 PMC5943138__F2 Control of B-1a cell development by instructive BCR signaling 10113 3492 50802 PMC5946330__F7 Proposed role of TGFB1 signaling in HASM cell shortening and hyperresponsiveness 4088 4087 387 4089 717 PMC5953448__F2 Breast cancer related pathways 55072 10616 81858 PMC5955471__F9 Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1 9817 571 3661 PMC5957297__F5 MAPK pathway indifference in melanoma 673 4286 367 7474 PMC5960485__F8 Network showing the most important gene interactions for the “regulation of canonical WNT signaling” (GO term GO:0060828) pathway 27161 1454 8312 8313 1855 7471 51176 4041 PMC5961473__F7 miRNA–gene interaction network.Notes: miRNAs are shown in pink, genes from Gmagenta are shown in magenta and genes from Ggreen are shown in green 22801 50509 1301 5521 7058 1278 477 3690 5328 493 5350 7169 185 1756 4638 7168 4660 29119 6330 7472 5228 PMC5964020__F2 Cortisol and catecholamine metabolism 7054 4129 1621 5409 PMC5964147__F7 HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer 3159 595 898 4318 4313 7078 PMC5964985__F2 Atrial fibrillation genes in calcium signaling and ECM–receptor interaction 1131 3356 5332 1956 2776 5578 5579 23236 2066 5737 6850 5336 6262 7273 6263 3690 3676 3339 2335 948 375790 3694 6383 3672 3909 5733 PMC5966388__F6 Dysregulation of the MiR-449b target TGFBI alters the TGFB pathway to induce cisplatin resistance in nasopharyngeal carcinoma 7045 7939 7046 7049 7048 5728 6935 1000 PMC5973613__F7 Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms 2864 10628 3480 PMC5973841__F2 Filoviruses inhibit the type I IFN response at multiple steps 3454 3455 7297 3716 4615 6773 6772 57506 7187 10010 10379 PMC5974360__F10 Wnt/Beta-catenin and hedgehog signaling in myofibroblast differentiation 7477 80326 11211 2735 1499 PMC5974440__F2 Regulation of stemness in the intestinal stem-cell niche 1950 1956 4041 1499 8549 2932 PMC5977062__F1 Diverse regulatory mechanisms of ncRNAs on Wnt signaling pathway 324 100302142 1499 57291 693197 4040 4041 PMC5979336__F10 Scheme of possible signaling pathways involved in regulating the functional state of Cx43 HCs, Panx1 Chs, P2X7Rs and Cx GJs in mesangial cells stimulated with AngII 387 24145 3553 PMC5983675__F2 Tumor necrosis factor receptor signaling in multiple sclerosis 7124 3458 3976 6387 5156 PMC5983750__F1 Molecular pathways involved in senescence 2475 472 3552 3586 PMC5983771__F1 Intracellular immune ecosystem in a virus infected cell 7097 7099 7098 6773 6772 7100 51311 54106 51284 4615 3661 10379 3663 57506 PMC5985050__F8 Proposed mechanisms by which PPARB/D regulates VLDLR levels and hepatic steatosis.PparB/D deficiency may result in an increase in VLDLR levels and hepatic steatosis through several mechanisms 4280 26291 7436 7038 83939 468 2260 PMC5985295__F2 IFN-dependent and -independent ISG transcription mediated by complexes comprised unphosphorylated STATs 3460 3455 3454 3459 3717 7297 6770 6100 PMC5987016__F1 “Immune Gate” of psychopathology – mechanisms of gut derived immune activation leading to psychiatric manifestations 3929 1392 4340 4099 4155 340451 969 7099 PMC5987909__F4 Stiffness-induced acute lung injury and pulmonary hypertension 6010 3383 1513 5053 PMC5992185__F2 Regulation of Ski and SnoN expression by different mechanisms 6497 4089 4087 3082 6722 4088 406991 407021 406947 406952 407010 4838 655 PMC5992512__F3 Various factors activated by fluid shear stress (FSS) can induce tumor cells metastasis 7423 3553 3481 2475 PMC6005202__F2 Towards a sustainable bio-based economy: Redirecting primary metabolism to new products with plant synthetic biology 727 729 718 PMC6005538__F6 Plasmatic membrane toll-like receptor expressions in human astrocytomas 114609 5728 4615 PMC6007054__F8 Diagram showing effects of 4-HNE on Keap1- and GSK3Beta-mediated Nrf2 degradation 9817 2932 5728 PMC6007949__F6 CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia 113 11314 5175 581 2475 PMC6010831__F9 Proposed model of the mechanism that links mitochondrial dysfunction and insulin resistance in non‐alcoholic steatohepatitis 3643 8660 7038 9927 4899 7019 PMC6020112__F2 Mechanisms involved in osteocyte mechanotransduction 4040 4041 847 PMC6021006__F6 Salidroside and liver fibrosis 3550 4088 4089 PMC6023281__F3 Neuroprotection and the PI3K/AKT/PTEN/GSK-3B pathway and SODs 5728 2932 4094 PMC6023969__F6 IL-37-mediated intracellular signaling cascades in eosinophils for the suppression of allergic airway inflammation 7097 6280 7099 7098 29108 9447 58484 114548 PMC6030169__F1 Intracellular exposure to intermediate ROS levels triggers conformational changes in KEAP1 via oxidation of its C-terminal cysteines, resulting in dissociation of the KEAP1-NRF2 complex and subsequent nuclear translocation of NRF2 192111 9817 9131 4149 PMC6031751__F8 CS negatively regulates IL-1B secretion in murine macrophages 7099 114548 3553 PMC6032276__F6 Differential regulation of skin barrier proteins by Rhodiola crenulata root extract 5017 2312 196 3713 1543 PMC6034278__F5 LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs 10561 4939 3665 54210 10964 5806 PMC6035417__F1 Molecular mechanism of apoptosis and necroptosis 197259 8737 11035 8717 PMC6036739__F7 The positive feedback of CCL2 and SQSTM1 contributes to chemoresistance 729230 8878 6347 2475 PMC6037329__F2 Cholesterol and Bile Acid -Mediated Regulation of Autophagy in Fatty Liver Diseases and Atherosclerosis 3949 7038 1581 19 9619 64241 64240 PMC6037732__F8 Cell cycle arrest and apoptosis of hepatocytes 595 898 5527 4280 PMC6037882__F4 Role of mucins in CSCs 4582 4585 94025 79923 PMC6039345__F6 Schematic diagram showing the role of Sulfatase-1 in inhibiting mesothelin expression in Carcinogenesis 10232 2821 6774 PMC6046295__F1 Mechanosignaling in normal keratinocytes and psoriasis 1499 2475 846 7054 PMC6049516__F1 Altered Hippo pathway signaling contributes to the kidney cystogenesis in Pkd1 mutant ADPKD 5310 5311 387 PMC6055003__F1 Notch pathway is regulated by short-range cell–cell signaling 4851 4853 28514 4854 10683 4855 54567 3516 100188776 3091 PMC6055827__F4 Lipopolysaccharide (LPS)‐ and serum amyloid A (SAA)‐mediated cellular production of inflammatory cytokines 7097 7096 10333 7099 7100 3654 4118 4615 51135 3656 7189 7187 29110 3661 PMC6056347__F3 The complex interplay between ER stress and liver damage and transformation(1) Unremediable ER stress in hepatocytes can elicit cell death, which might proceed through apoptotic, necrotic, or pyroptotic pathways or a combination thereof 3603 114548 834 836 PMC6057902__F2 Extended, context‐specific melatonin receptor signalling pathways 596 3717 581 23410 23411 2308 PMC6060673__F1 Immunomodulatory approaches for the treatment and prevention of neonatal sepsis 7099 929 7054 3576 3553 3569 PMC6061668__F1 Endothelial injury pathways in thrombotic microangiopathies 7450 7018 3075 3426 4353 3383 7412 PMC6062504__F6 DLX1/DLX2 may influence MAPT via WNT or GABA signaling pathway 6585 23316 1745 431707 1746 7471 2558 80326 2562 2563 4137 PMC6067656__F1 Schematic representation of human adrenal steroidogenesis 5447 3284 1589 1583 1586 3293 6716 9060 PMC6070815__F5 Pathways of the annotated DE genes and lincRNAs in the adipose tissues of high- and low-FE pigs 491 7434 2778 808 5566 5136 3991 9331 8013 79993 225 5244 PMC6072467__F4 Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides 4536 192 6476 PMC6072627__F2 Intracellular activation of innate immune signaling by hyaluronan matrix 7097 7099 7100 10333 960 114609 4615 387 PMC6073374__F2 Sonic Hedgehog (SHH)/Patched (PTCH1) and WNT signaling pathways 6469 5727 6608 2932 324 1499 2735 2736 2737 PMC6086351__F1 Small Cell Neuroendocrine Tumors: Cell State Trumps the Oncogenic Driver 1956 367 2064 5925 7157 PMC6087588__F2 Proposed signaling mechanisms of adiponectin in prevention of ischemic stroke 51094 79602 5465 7412 3383 PMC6095977__F1 IRF9 signaling via the JAK–STAT pathway and antagonism by viral proteins 3454 3455 3716 7297 6773 6772 10379 7084 PMC6096407__F1 Several lncRNAs interact with transcription factors recruiting them to their target genes (e.g 100775107 1499 6925 PMC6099164__F2 Transforming growth factor‐B (TGF‐B) promotes T helper 17 (Th17) differentiation through multiple mechanisms 7039 50615 3559 387 4087 9475 9021 4088 6774 4089 3662 8320 50943 861 PMC6102278__F8 Fas-mediated EGF-induced EGFR signaling A proposed model of the robust EGF-induced EGFR signaling pathway mediated by the pro-survival, phosphorylated Fas that can lead to aggressive behavior of cancer cells is presented here 1950 7525 6774 355 6714 595 1956 PMC6102891__F7 Signaling pathway of OS and pregnancy (a brief view) 2309 8915 9817 2729 PMC6103408__F9 IFNG-induced autophagy is regulated by HMOX1 3458 22926 5594 5595 8878 345611 1432 3716 3717 440275 1051 7942 8678 8408 PMC6104109__F2 Canonical pathways of oxidative phosphorylation and mitochondrial dysfunction 4708 1347 4728 PMC6119869__F3 The paradoxical HH pathway 6469 51684 2735 PMC6122628__F2 HUWE1-mediated proliferation/differentiation 6469 10075 474 4149 4609 283120 1499 PMC6123311__F3 Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins 25970 3717 9021 5443 PMC6124012__F6 Sterol regulatory element-binding protein 1 signaling 2194 3949 1717 PMC6124548__F6 Somitogenesis and somite patterning 2247 652 6469 2253 655 7043 PMC6126134__F1 Nuclear factor KB (NFKB) activation signaling pathways.Canonical NFKB pathway: the canonical pathway is inhibitor of KB (IKB) kinase (IKK)-dependent and IKB-dependent 4055 613 958 5971 PMC6129280__F5 piMGM: incorporating multi-source priors in mixed graphical models for learning disease networks 6300 5290 5295 10000 5603 5600 4772 5293 5530 5266 PMC6129528__F4 Regulation of cell signaling pathways involved in cancers by KDM2B 1499 84678 2146 2475 PMC6131564__F3 Sub-pathway of chemokine signaling pathway identified on the basis of sub-pathway strategy 25759 4118 7993 2885 4893 2268 5604 10681 401288 2783 284185 22808 PMC6134416__F3 在SCLC中，受体酪氨酸激酶及其配体通常呈过表达状态。缺陷性受体酪氨酸激酶及它们各自的生长因子包括：VEGFR/VEGF, c-Kit/SCF, c-MET/HGF, FGFR/FGF以及IGF-1R/IGF。通过多种通路的激活，包括在SCLC中失调的PI3K/AKT/mTOR通路，在存活、凋亡、细胞周期调节和翻译过程中发挥作用。Receptor tyrosine kinases and their known ligands are often overexpressed in SCLC 3082 3480 5728 2475 PMC6135699__F3 Modulating Inflammation through the Negative Regulation of NFKB Signaling 7186 7187 5971 6387 10563 PMC6138501__F1 Inflammasome activation and purinergic signaling in Chlamydia-infected cells 84890 3553 7099 PMC6142439__F2 Complement-mediated hemolysis in cold agglutinin disease 717 718 727 PMC6142509__F1 Activation and regulation of the alternative complement pathway 629 718 1675 3075 3426 PMC6142689__F5 Pathway of NRF2-mediated oxidative stress response 1356 9451 2952 PMC6148250__F8 S100A10 and PAI-1 are regulated by Smad4-dependent TGFB1-mediated signaling and FOXC2-mediated PI3K signaling 7040 2246 7046 4087 4088 4089 2475 2303 6281 PMC6149728__F1 Schematic model for IL-1 mediated induction of IL-22 in cancer 114548 3553 196 3603 PMC6155173__F5 RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation 7124 7098 7099 8717 8737 11035 197259 PMC6155262__F7 CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1A/VEGF-A pathway in colorectal cancer 6363 1236 7422 2002 PMC6158481__F4 WNT/Beta-catenin signalling 4040 4041 324 2932 1499 PMC6158482__F1 Neutralization of the interleukin-12/interleukin-23 pathways associated with T-cell activation and differentiation 3595 149233 3594 7054 PMC6160959__F5 Orlistat from PxEA perspective 335 7534 3500 5603 2885 102 7531 4023 2194 409 11343 5406 5664 9459 8513 4851 PMC6162242__F8 A schematic for an miR-532-5p/KRAS-NAP1L1/P-ERK/ETS1 feedback loop 3845 4673 2113 PMC6162445__F3 Mechanism of GPCR bias agonism involves insulin receptor activation 4829 545 10682 4318 3667 PMC6164894__F2 Canonical TGFB1 signaling pathway 7040 4087 4088 4089 PMC6165716__F8 Schematic showing PDK4 as a checkpoint in NFKB/TNF-mediated apoptosis 7124 836 5166 842 PMC6172370__F8 P38 MAPK signaling pathway in the regulation of the NLRP3 inflammasome and macrophage pyroptosis 7097 114548 3553 PMC6172484__F4 Gene network analysis of DE genes in the infected group 5143 55331 440854 25987 92291 8871 84699 1277 5582 84940 7058 5357 3976 8320 540 3001 112744 479 3596 4582 3605 492 50616 30009 85407 150082 PMC6182269__F1 Cell intrinsic dysregulation of innate immune signaling in MDS HSCs 3556 3606 929 3553 3554 4615 114609 51135 114548 3656 3654 7189 497189 5970 3178 3603 3569 PMC6187096__F2 Ginsenoside Rh2 epigenetically affects genes in the cell-mediated immune response pathway 1072 25953 115727 25780 22999 287 2796 25837 8525 969 59082 1128 834 55553 3281 24145 100506742 93663 5927 1488 838 29994 PMC6192992__F6 Scheme depicting role of HORMAD1 in DSB signaling and repair 472 672 9025 84072 PMC6193168__F5 Involvement of mitophagy in the transportation of amorphous calcium phosphate (ACP) precursors from the mitochondria to the extracellular matrix in stem cells with osteogenic potential 4090 4086 3920 3916 650 4089 57154 860 65018 PMC6193418__F1 Cell‐intrinsic pathway of apoptosis 596 581 317 PMC6197618__F6 RHBDF1-facilitated membrane trafficking of pro-TGFA via CCV pathway 1956 6868 64285 162 7039 PMC6198264__F3 Pathway of biosynthesis and metabolism of testosterone, primary estrogens and progesterone during pregnancy 1586 3283 1528 1543 412 1588 3292 1551 PMC6204373__F1 Role of TRAFs in TCR-, costimulatory receptor-, and cytokine receptor-associated signaling pathways controlling TFH differentiation 29851 940 3466 29110 6772 50615 6774 3575 604 643 7189 7188 7186 7185 7187 PMC6209728__F2 Osteocyte role in MM bone disease 6348 4040 4041 7124 4312 PMC6211389__F3 Type I interferon (IFN) gene induction by IFN regulatory factors (IRFs) on innate recognition of cytosolic nucleic acids 57506 115004 51428 3428 29110 3661 3665 3394 3663 PMC6213971__F3 Regulation of PTPIP51 in melanoma 2322 673 4067 PMC6217750__F4 Redox Regulation of Heme Oxygenase-2 and the Transcription Factor, Rev-Erb, Through Heme Regulatory Motifs 6095 9611 8841 2932 3065 10467 PMC6226322__F7 ZFPM2-AS1, a Novel lncRNA, Attenuates the p53 Pathway and Promotes Gastric Carcinogenesis by Stabilizing MIF 102723356 4282 581 PMC6235681__F2 Details of the SHH and Akt pathways 6469 6608 5727 2475 5074 51684 PMC6237070__F1 Treg suppression 355 941 942 324 3902 PMC6252103__F2 aspartate Beta-hydroxylase (ASPH) may affect the progression of pancreatic cancer through the activation of Notch signaling pathway 4851 100188776 5743 4318 7422 PMC6260778__F3 Effect of glycolysis on Tregs 940 7097 2645 2308 2309 4609 50943 PMC6260778__F7 Low pH induces differentiation of T cell into Tregs 4088 6774 4089 5728 50943 PMC6260778__F8 Effects of the metabolite, RA, on Tregs 4088 4089 50943 PMC6262606__F1 Nuclear factor-kappa B signaling pathway 4055 613 958 5971 5970 PMC6265312__F1 Triggering receptor expressed on myeloid cells-2 (TREM2) in microglial survival and metabolism 54209 348 5091 102 6850 331 2475 2932 1499 79792 595 3553 3603 PMC6266631__F6 KDM5A function and its expression control in proliferating NPC and differentiating astrocyte 2247 1950 1270 5927 6774 2670 PMC6269490__F1 Roles of CO in metabolic homeostasis 26291 468 83667 83939 PMC6277787__F12 LPS signaling pathway in teleost macrophages 7097 10392 64127 PMC6279568__F5 Resistance to MET and MET/MAPK/ERK inhibition in DFCI358 1956 3480 3845 3667 3265 6774 126669 PMC6280363__F3 Crosstalk between surface TLRs and dysregulated metabolic factors in diabetes 7097 7099 3553 23411 PMC6280631__F2 The melanogenesis pathway shows where common ENAMs affect the pathway 4157 673 4286 7306 10117 PMC6283569__F6 E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling 3479 3667 8660 PMC6287140__F4 Putative inhibitory pathway of Ac-ME in mediating the inflammatory response 7099 7097 4615 6850 6714 3569 3553 PMC6291580__F1 Genetic determinants of cardiovascular risk in SLE 100506157 283635 3466 3394 6775 3458 29949 3105 PMC6292306__F1 Calcium movement into the mammary gland regulates maternal calcium homeostasis during lactation 846 84876 5745 PMC6293652__F7 Mechanism model of PIK3CA E542K and E545K mutation-mediate regulation of proliferation and glucose metabolism via the Beta-catenin/SIRT3 in cervical cancer 2932 1499 23410 3945 PMC6297399__F5 String pathway enrichment analysis revealed strong associations (P=0.007) of the identified prognostic genes (colored nodes) 4194 2776 4193 6601 6595 86 3845 6597 3815 6599 5156 1956 6598 1950 4254 5781 3082 PMC6299370__F1 The activation of Wnt/Beta-catenin signaling by different oncogenic lncRNAs in liver cancer 100885798 324 2932 1499 10664 56998 PMC6299398__F3 Consequences of driver gene mutations in canonical Wnt signaling 1499 5290 3667 55294 2932 PMC6299639__F2 Mechanism of HSV evades host immune responses 718 7098 7097 7189 4615 727 6041 6035 57506 6772 83939 7187 29110 3661 3428 PMC6300493__F2 WW domain protein roles in genomic stability 545 672 472 83737 51741 56254 64750 PMC6300493__F7 E3 modulate breast cancer cell invasion and metastasis 1950 1956 8239 57154 11059 7852 83737 64750 PMC6305227__F1 Propionibacterium acnes: loss of diversity, selection of phylotypes, and its different target activities in acne 1392 7097 960 PMC6306406__F1 Schematic elucidation of IL-33 90865 6761 3556 4615 3654 51135 7189 PMC6307528__F5 Crosstalk between the Rho kinase and BMP-2 signaling pathways 650 4086 387 6010 PMC6311104__F2 Steps in miRNA biogenesis 29102 54487 26523 192670 27161 192669 PMC6311434__F7 Schematic molecular mechanism of SHH pathway regulation by HER2 in breast cancer cells 6469 2932 2736 PMC6315409__F3 Biosynthetic pathway for very-long-chain fatty acids (VLCFA), the dicarboxylic acid 20:4 (DCA 20:4), and the very-long-chain dicarboxylic acid 28:4 (VLDCA 28:4) 54898 60481 83401 64834 6785 PMC6320226__F1 Schematic diagram summarizing the regulatory role of the Id1/IGF2/VEGF/VEGFR pathway in esophageal squamous cell carcinoma (ESCC) progression 3481 3397 6374 PMC6320319__F1 Schematic summary of the Wnt signaling derangements and the different traits of metabolic syndrome 387 9475 6934 471 6667 7038 4040 PMC6324535__F7 Working model 1499 1021 1019 PMC6329798__F1 ABPs used for caspase analysis 253868 596 841 842 843 PMC6330656__F1 Targeting ERBB Activation Mediated by CD74-NRG1 972 3084 2064 2065 PMC6331455__F5 Role of Nrf2 in HCC 9817 9965 2264 2932 PMC6335102__F13 ANG II signaling in aging 367 7248 2475 PMC6335777__F2 Ketamine on the glutamatergic synapse 2597 6009 29904 2475 627 PMC6336706__F4 Model showing the possible pathways of neuropeptide Y-induced neuroprotective effects in Alzheimer's disease 4852 4803 627 PMC6337644__F3 Telomeres are cap-like features at the ends of chromosomes that help protect them when cells divide 546 1616 1431 65985 PMC6337850__F6 A working model: N-Myc differentially regulating miR-421/ATM pathway contributes to ADT resistance and Enzalutamide resistance development of prostate cancer 472 693122 2146 1878 8178 PMC6347506__F2 Integrative regulation of physiology by histone deacetylase 3 8841 2874 79718 6907 9575 7018 10499 5629 10682 PMC6347506__F6 Integrative regulation of physiology by histone deacetylase 3 8841 2874 79718 6907 7018 3458 587 272 PMC6349890__F7 Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factorB and NLRP3 inflammasome signaling pathway 114548 7006 100124696 PMC6351931__F10 Schematic diagram of the signaling pathway relevant to HKMT-induced pleural fibrosis in pleural mesothelial cells (PMCs) 50507 7099 1636 PMC6354055__F1 Mutation Hotspots in the Beta-Catenin Gene: Lessons from the Human Cancer Genome Databases 2932 1499 324 51176 PMC6357032__F2 Classification of caspases 596 4170 331 637 581 PMC6357062__F1 Intracellular negative immune regulators of dendritic cells (DCs) 8651 5970 6774 2309 9021 PMC6359724__F1 Oxygen- and hydroxylase-dependent mechanisms regulating hypoxia-inducible factor 1 (HIF-1) activity 26118 10868 7345 9101 2271 PMC6360685__F2 The mechanism of miR-34 in EMT 4194 7046 4089 4088 1499 51176 6774 182 PMC6361534__F1 Complement cascade and its regulators 718 721 727 735 966 729 PMC6363221__F9 Systems biology reveals how altered TGFB signalling with age reduces protection against pro-inflammatory stimuli 712 713 3689 3691 7096 7097 10333 7099 182 3714 4087 4088 8832 4322 4090 4086 51162 PMC6363687__F4 FGFR1 pathway promotes NFKB signaling 23118 257397 10454 8717 2260 PMC6364001__F8 Proposed model of intracellular pathways engaged within, and functions of, HSV-specific CD8+ T cells from protected ASYMP individuals 3572 3455 3454 3717 3716 3559 3560 6774 6773 6772 3003 3002 7297 3570 PMC6365421__F1 Chaperone mediated autophagy mechanism 2670 5879 23239 PMC6365678__F7 CXCL16/CXCR6 interaction promotes endometrial decidualization via PI3K-PDK1-AKT-Cyclin D1 pathway 58191 10663 7216 3484 5617 595 PMC6366148__F3 PI3K/Akt/mTOR pathway activated by IL-2 and CD28 signaling and growth factors 940 3575 2475 PMC6367847__F2 NLRP3 inflammasome pathways and putative mechanism by which cyclic stretch negatively regulates IL-1B secretion in murine macrophages 7099 114548 3553 PMC6372796__F9 Proposed model of IFN and inflammasome activation by HCMV and IL-1B inhibition by IE86 3454 3455 115004 79792 9447 6772 6773 3661 3603 4284 PMC6381212__F8 Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma 101805492 2475 581 PMC6381368__F6 Schematic representation of the suggested pathway by which CAFs induce cell proliferation, EMT and metastasis in CRC cell 595 2475 3845 PMC6382377__F1 Lymphopenia and DMTs for relapsing forms of MS 1723 1043 1878 8178 PMC6383147__F4 Positive feedback linking oxidative stress with enhanced p62 expression, Kelch-like ECH-associated protein 1 (KEAP-1) autophagic degradation, and stimulation of antioxidant enzyme expression 9817 4094 8408 29110 PMC6383653__F4 Proposed model for the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1 signaling axis in HGF-mediated lamellipodia formation 3082 5879 124976 PMC6385460__F1 The AMPK/mTOR signaling pathway in TNBC tumor growth and progression 64223 2475 8408 1956 6774 6714 PMC6389150__F5 Model of NDV V protein regulating apoptosis in DF-1 cells 596 9352 581 PMC6389615__F1 Schematic representation of genes involved in osteoclast-poor and osteoclast-rich osteopetrosis 4286 5970 29887 PMC6389897__F2 Folate metabolism is linked to the homocysteine metabolic pathway 635 4397 5212 875 4524 100188776 PMC6396335__F1 Assembly of the interferon (IFN)G receptor (IFNGR) and activation of Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling 3716 6772 8651 8554 3460 3459 PMC6397348__F9 Diagram: BPI fold-containing group A member 1 (Bpifa1) regulation of noncanonical Toll-like receptor 4 (TLR4) and interferon (IFN) signaling 51297 4280 7099 3458 3594 3717 4615 6773 6772 10379 3661 3665 3663 6775 3627 PMC6397540__F1 Proposed model of cell signaling associated with the ALK5-SMAD2/3 tumor-suppressive arm identified by Monsivais et al 7048 92 93 659 4090 4086 4087 4088 PMC6397842__F2 Schematic overview of bone cells and extracellular matrix components involved in regulating bone homeostasis 50964 22943 64132 100187761 6678 5358 PMC6404485__F9 Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage 948 324 1499 PMC6405411__F8 PGE2 synthesis, receptors, transport, and metabolism in granulosa cells 5733 5734 5732 5731 5321 5743 9536 3248 3973 PMC6405822__F1 BMP signal transduction 4090 4086 4089 4091 4092 PMC6405828__F2 TYRO3 signaling pathway 7301 595 331 PMC6406281__F1 Cholesterol homeostasis in normal cells 3949 3156 19 PMC6406288__F3 Consequences of indoleamine 2,3 dioxygenase (IDO) overexpression on the antitumoral immune response 196 3458 3815 2118 PMC6409601__F4 Hypermodification of m5C34 in anticodon of cytoplasmic and mitochondrial tRNAs 54888 63899 8846 24140 PMC6412245__F9 Schematic diagram shows the therapeutic effects of ergosterol on diabetic nephropathy 4087 4089 5111 PMC6413278__F7 The proposed mechanisms for the inhibitory effects of MS-275 on osteogenesis in VICs 4920 2932 1499 387 4040 4041 PMC6416842__F1 Simplified overview of one-carbon metabolism pathway 635 875 4548 4552 4524 PMC6417856__F10 The main findings are illustrated (A) 1103 6616 1134 782 6261 PMC6421647__F6 hBM-MSCs-Ex treatment alleviates liver fibrosis in both HSCs and liver fibrosis tissues through inhibition of Wnt/Beta-catenin signaling (PPARG, Wnt3a, Wnt10b, Beta-catenin) and the downregulation of downstream gene expression (WISP1, Cyclin D1) 7480 89780 1499 595 PMC6422174__F1 Linking Signaling and Selection in the Germinal Center 2308 59067 2271 958 PMC6424867__F6 Arenaviral proteins (NP and Z) inhibit the RIG-I/MDA5 and NFKB pathways 7097 4118 4615 57506 3661 3665 3654 PMC6433665__F3 Common alterations in fluorosis‐proliferation and differentiation 2247 652 4086 4090 4093 4087 4088 1499 PMC6433747__F1 Androgenic-inducible miRNAs involved in the process of BC progression 367 3845 116435288 6659 960 PMC6433792__F1 Phosphodiesterases (PDEs) in the pituitary gland: After stimulation of somatotroph cells via GHRH, the G protein coupled receptor is activated, which causes a conformational change of the receptor 2691 5144 5141 9049 PMC6441168__F3 Functional network of cancer derived EVs in GC microenvironment 9242 7099 3146 PMC6443339__F12 Regulatory effects of H2S on PCSK9 expression and lipid metabolism 3949 255738 19 PMC6444363__F6 Tat promotes astrogliogenesis over neurogenesis through its binding to Notch to activate the Notch signaling pathway 3516 388585 3280 PMC6445872__F5 SIRT6 also attenuates NFKB signaling via histone H3K9 deacetylation at the chromatin level 51548 3717 6774 PMC6447799__F3 Leptin signaling pathways 3717 6774 2475 9021 PMC6456510__F5 Possible regulatory association of miRNA let-7-related gene networks 154 55662 9069 PMC6457004__F5 Schematic model in which HMW FGF2-mediated FGF23 stimulation of chondrocyte differentiation and OA is partially through modulation of the Wnt/Beta-catenin pathway 50964 2247 7477 8074 8313 1499 11096 PMC6457250__F5 Metabolic control of macrophage function 652 3659 3553 6774 PMC6460326__F1 HPV16 endocytosis and trafficking to multivesicular bodies 967 977 23363 PMC6460433__F7 Model for regulation of antiviral innate immunity by BA metabolism 11309 1593 6714 3661 PMC6460856__F2 Mechanisms by which carbon-based nanoparticles induce cytotoxicity of macrophages 3603 637 114548 PMC6462535__F6 Ethanol regulation of stem cell differentiation via activation of RA signaling 5950 64220 157506 9249 9227 8854 1382 PMC6463672__F8 LINC01354 and Wnt/beta-catenin signaling pathway 100506795 3184 1499 6925 4316 PMC6468357__F4 FOXK2 role as an oncogene in cancer 3607 1499 6662 595 175 PMC6468861__F2 miRNA biogenesis pathway and various single nucleotide polymorphisms (SNPs) occurring at different steps of the pathway that play a pivotal role in prediction of breast cancer risk development 29102 54487 27161 PMC6471541__F11 Proposed schematic depicting the signalling pathway via which TGFB1 promotes the osteogenesis and migration of osteoblasts 4313 860 4318 PMC6471594__F3 Cilia-dependent regulation of PDGFRA signaling pathway 8100 5156 5266 90410 5159 PMC6471940__F4 Molecular signaling in cancer 1499 5728 3280 4193 PMC6473256__F8 Cilia-dependent and independent activation of Gli proteins 5727 6469 51684 2735 2736 6608 10215 3170 PMC6475556__F7 The mechanisms of total triterpenes of the E 7099 581 1728 PMC6475670__F4 Interaction network showing miRNAs and their predicted and validated targets 7124 836 4791 4790 7186 8717 841 PMC6481643__F10 Novel IL-1Beta-ILC3-IL-2 circuit is essential for the maintenance of Tregs and immunologic homeostasis uniquely within the small intestine 3553 50943 4615 64127 PMC6482165__F1 Hypothalamic regulation of energy homeostasis in healthy (blue) and obesity (pink) 23237 7099 4159 4852 181 5443 6774 2308 4160 PMC6482288__F3 Schematics presenting mechanisms of actions of approved and selected experimental cytokine and cytokine receptor agonists and antagonists 7850 7124 100187907 3554 PMC6484401__F1 Lining up for quality control: linear ubiquitin and proteotoxicity 6667 90268 81858 3064 PMC6487735__F1 Schematic representation of the linkage between SAMe, SAH, sarcosine metabolic pathway and methionine cycle 29958 27232 1757 51268 PMC6489690__F3 MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer 1499 6423 64750 11197 8312 PMC6495170__F2 Ceramide metabolism 1674 2581 10715 29956 204219 253782 91012 79603 6611 PMC6497036__F10 Proposed mode of action for RHOA to maintain TE characteristics in the expanding blastocyst 387 154796 4771 PMC6497758__F2 Proposed Schematic diagram of Mda5 signaling pathway in Teleost based on a Mammalian Model 29110 3661 3665 57506 PMC6499991__F6 Proposed model of participation of SNHG1 in the regulation of signaling pathways that contribute sorafenib resistance in HCC cells 23642 6520 5728 2475 595 PMC6500763__F1 Signaling cascades involving EGR1, PTEN, DMP1, ARF, and the p53 network 1958 4193 7040 5728 27113 PMC6506535__F6 T helper cell differentiation pathway of MAIT cells in comparison with conventional T cells 7049 149233 6774 958 3559 942 940 3566 941 7046 7048 50943 6775 7054 29851 604 2625 59067 6778 50615 PMC6507908__F9 Elevated androgens alter intrafollicular regulatory mechanisms that impact the expression of VCAM1 and the expansion of VCAM1+ cells in the stroma 7026 2492 1586 367 1588 7412 PMC6509174__F6 Wnt/Beta-catenin signaling pathway regulated by PARG gene silencing during BaP-induced lung cancer 7472 8505 324 2932 1499 PMC6512043__F8 T10 inhibited NFKB activity via miR155-5p/SHIP1 axis 7189 3550 3603 7096 7097 7099 PMC6518377__F1 The old dog 181 4160 5443 1363 PMC6518824__F3 Schematic indicating the pathway from Micronucleus formation to activation of the cGAS-STING pathway, and canonical and non-canonical routes to Type I interferon response 115004 3661 5971 PMC6520171__F3 Depiction of RBP4 immunomodulatory actions locally within and how this gives rise to insulin resistance 5950 3553 324 920 PMC6522942__F2 TLRs-signaling in microglial cells in different neurodegenerative disease progression 51284 7099 7100 7097 3553 7096 54106 4615 4248 PMC6523677__F2 MicroRNA-mRNA network constructed using CyTargetLinker 1633 1635 100616259 6240 978 6241 PMC6525179__F5 Gene expression and 14C fatty acids production in LC-PUFA synthesis pathway of liver between knockout (KO) and wildtype (WT) salmon 54898 6785 1368 PMC6526672__F2 Signalling pathways involved in glucose metabolism‐regulated NLRP3 inflammasome activation 3098 22933 3091 5610 114548 PMC6529242__F5 Mechanisms induced by MC-GAG on osteoprogenitors and osteoclast progenitors 4090 4086 4089 PMC6529740__F2 Potential and confirmed phenotypic features of C9orf72 HRE-associated microglia in FTLD/ALS 5901 203228 713 7305 54209 968 PMC6532258__F7 Proposed model for GPAA1 promoting growth and metastasis of gastric cancer 8733 1956 2064 PMC6533481__F7 The molecular mechanism involved lncRNA MEG3 affecting the fraction healing of mice after tibia fracture 7480 2932 1499 55384 1300 860 2146 PMC6535055__F9 The mechanism graph of the regulatory network of PIEZO2 under different circumstance including normal (A) and cancer (B) 63895 50937 693122 8009 PMC6539070__F2 Molecular mechanisms of adipogenesis 652 23090 1499 9370 PMC6539579__F5 Roles of c-Myc in colorectal cancer (CRC) organoids 57214 639 2735 PMC6540809__F1 B cells mediate MS pathology through antibody-dependent and antibody-independent mechanisms 5091 10563 4050 4049 920 PMC6542018__F1 Estrogen receptor (ER) activity in breast cancer - canonical (classical; ligand-mediated) and non-canonical (alternative; ligand-independent) pathways of ER activation 2248 2255 2252 2263 2260 3169 4781 4904 PMC6542701__F2 ER’s coregulatory proteins and genomic binding sites differ between endometrial cancer and breast cancer cells 3169 2625 2118 7018 9687 PMC6545170__F2 Wnt signaling pathway 2932 1499 324 4040 4041 PMC6545262__F2 The Notch pathway in human and mouse Th2 cell development and function 2625 920 3458 PMC6549003__F6 Proposed model for an auto-regulatory feedback loop between the miR-17-92 cluster and the Wnt/Beta-catenin/LEF1 signaling pathway 2487 8322 324 1499 1869 51176 PMC6549020__F1 cTAZ: a safeguard factor of antiviral response 29110 130399 50943 3661 6772 10379 6773 PMC6553925__F6 Summary of all identified phosphosites in LPS signaling pathway 7099 3656 4615 51135 11213 7189 3654 7186 10318 79155 29110 257397 23118 929 114609 PMC6554373__GA Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level 2056 5447 3717 627 596 PMC6557297__F4 Possible replication-coupled ICL repair mechanisms 57697 641 10293 55247 PMC6562674__F1 Hedgehog signaling pathway 6608 5727 2735 2736 2737 51684 PMC6563055__F4 NOX4-related mechanisms in thyroid carcinogenesis 4088 50507 7018 PMC6563926__F1 Physiological pathways of LRRK2 activity 120892 7099 8934 10890 PMC6566291__F1 TGF-Beta-mediated skeletal muscle fibrosis 1636 7046 4087 4088 4089 PMC6566851__F5 Effect of butyrate on the Wnt signaling pathway Butyrate can increase Wnt1/2/3 expression, which bind to their receptor Fzd to activate Wnt signaling pathway 7471 7473 7472 1499 PMC6579773__F2 Alternative pathway of the complement system 718 727 729 PMC6580124__F7 Mechanism of rapamycin’s anti-angiogenic and anti-lymphangiogenic effects in melanoma 2475 7424 2277 7422 PMC6581210__F1 Mitochondrial pathways of apoptosis and venetoclax mechanism of action 572 637 581 638 PMC6582183__F2 Schematic portrays crosstalk between miR29 family and various signal transduction pathways involved in pathogenesis of Diabetic Nephropathy 407021 7471 1499 9759 407026 4088 1803 9817 PMC6584916__F1 Structure of the Slit/Robo protein family and their interaction 2335 54538 6091 64221 6092 PMC6584916__F5 Upstream regulatory molecules of Slit/Robo 5371 6586 9353 23512 2146 8726 494332 407047 23032 6092 64221 6091 PMC6585057__F7 Summary and schematic diagram of this study 29126 3627 6772 4599 2632 8638 3107 3665 3105 3106 6352 3429 PMC6585406__F1 OAS/RNase L pathway 4938 6041 4939 4940 8638 PMC6586148__F6 SHP2–ERK1/2 inhibition and STAT3 activation by Sunitinib 3717 4656 3679 PMC6590709__F5 Glycosylation in health and disease 7124 355 1956 PMC6600513__F1a Signal Exchange through Extracellular Vesicles in Neuromuscular Junction Establishment and Maintenance: From Physiology to Pathology 367 324 4593 4038 2147 PMC6602412__F3 M6A on the JAK/STAT signaling pathway 3716 3717 3718 6772 6774 PMC6602956__F6 Schematic diagram of NPY(1–36) expression and secretion in activated LX-2 cells and the signalling pathway involved 4852 4886 2475 1977 1999 PMC6603210__F1 IL-1F family signaling complexes 10068 27179 27177 90865 3554 4615 PMC6604468__F7 MUC17 inhibits the progression of human gastric cancer by limiting inflammatory responses 140453 6010 1044 PMC6604516__F7 Graphical signalling pathway of the effect of APPBP2 on NSCLC via PPM1D and SPOP.The blue lines indicate the activation of the targets according to our experiments or published researches 10513 8493 367 1019 8405 PMC6604619__F10 Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor 2180 5465 1582 1593 8309 6342 PMC6605495__F2 Helper T cell differentiation and HBP 324 920 50943 6772 6778 2625 6774 PMC6606950__F3 Chinese herbal medicines inhibit the activation of the HIF-1 pathway in cancer treatment through different targets 5858 5728 2475 7189 6774 PMC6620596__F2 STAT3 signaling pathway and inhibition approaches 1950 3569 3570 1956 3717 6714 6774 10401 1357 PMC6628023__F5 Schematic illustration of the molecular pathway of AhR and its effects on FSHR and survival 196 2492 405 PMC6629768__F1 Some examples of lncRNA mechanisms that unfold in the cytoplasmic compartment 100506311 652995 1869 128338 8408 PMC6635557__F3 Schematic model of AngII-induced and mechanical stress-induced signaling pathway in vascular smooth muscle caveolae 857 859 1956 PMC6638919__F10 NADPH oxidase 4 mediates TGFB1/Smad signaling pathway induced acute kidney injury in hypoxia 4087 4089 50507 PMC6639958__F8 Proposed model of MEK as a key regulatory pathway of the IFN response against RV and RSV in airway epithelial cells 1956 3454 3455 55872 7098 3661 6774 6773 PMC6639976__F5 CXCL13 in prostate cancer 10563 643 5728 PMC6640697__F13 In vivo safety evaluations of MOv18 IgE 2185 6850 5777 3688 567 5595 PMC6651415__F5 Possible mode of cell death pathway in Caco-2 cells 355 599 10017 7124 638 8767 939 PMC6652118__F1 RIG-I/MDA5 signaling pathway RIG-I and MDA5 are first activated by recognition of PAMP dsRNA, which causes them to interact with MAVS 3654 57506 3665 29110 3661 PMC6657652__F6 Antibactericidal mechanisms of C5a-TLR2 cross-talk induced by P 727 7097 114609 4615 387 PMC6668582__F1 Urea cycle pathway 162417 5009 435 PMC6669812__F2 Leptin binds to the LEPR and mediates multiple downstream pathways 3953 2885 6774 2475 4316 1375 1977 790 PMC6677404__F2 Schematic diagram illustrating a role of PI3K, Rho and ROCK pathways in hypoxia-induced ATP release and ATP-mediated angiogenic effects in vasa vasorum endothelial cells 387 2309 1958 PMC6678174__F1 Mitophagy pathways 10133 65018 664 139341 25820 PMC6678550__F1 Potential signaling pathway between expression of bone morphogenetic protein receptor type II, HDL cholesterol, and vascular remodeling in pulmonary arterial hypertension 19 659 5053 PMC6683584__F8 The mechanism of Notch1 signaling and CXCL12/CXCR4 axis in GICs self-renewal, invasion and tumor growth 6387 7852 4851 3516 2475 PMC6684391__F6 Proposed interaction induced by azithromycin (AZM) is depicted 3458 7099 3716 7297 4615 6772 5970 3553 3569 PMC6685593__F10 Piezo1 promotes tumorigenesis of prostate cancer 9780 595 1019 2475 PMC6691039__F1 Platelet Theory 6850 27040 1003 PMC6695817__F1 Mitochondrial antiviral signaling protein (MAVS)-dependent antiviral signaling pathway 57506 3661 3659 163702 3455 PMC6699068__F1 Notch signaling in bone tissue development 28514 4853 4851 4854 1499 22943 50964 PMC6700477__F1 SHH pathway activity leading to phenotypical changes in esophageal epithelial cells 5727 6608 6469 2736 2735 652 6662 PMC6702832__F5 Modulation of the NFE2L2 pathway in keratinocytes 2810 4780 196 4094 PMC6702832__F6 Modulation of the NFE2L2 pathway in melanocytes 4780 9817 4094 5594 PMC6704701__F6 Illustration of the mechanism of SOX2 promotion of breast cancer cell migration 5879 6657 4739 3091 PMC6706905__F7 Systemic diagram of the mechanism of S1PR1/STAT3 signaling pathway 1901 6774 595 4609 PMC6711159__F1 Closer Look at Pyroptosis 6279 7099 4615 27035 1499 7189 114548 834 3553 3606 PMC6720712__F7 Diagram illustrating the underlying mechanism by which that miR-15a regulates the differentiation of chicken intramuscular preadipocytes by targeting ACOX1, SCP2 and ACAA1 in the PPAR signaling pathway 30 51 6342 PMC6721482__F2 The regulation of Keratin 6, 16 and 17 during skin wounding and in psoriasis 7098 1956 6772 6774 2475 50616 3458 7124 PMC6721535__F1 The catecholamine biosynthetic pathway in an adrenomedullary chromaffin cell or a pheochromocytoma cell 5212 1621 27040 5409 7054 PMC6723199__F1 The metabolic pathway of caffeine 1544 1571 10 1548 PMC6724002__F6 Schematic representation a proposed pathway for hispidin-induced Nrf2/ARE-mediated cytoprotective proteins 2730 1728 2729 PMC6742496__F7 Proposed Model - LPCAT1 Links Genetic Alterations of Key Components of the Growth Factor Receptor Machinery with Plasma Membrane Remodeling to Drive Tumor Growth, Generating an Actionable Dependency across Cancers 1956 79888 5091 PMC6750892__F11 Proposed mechanism for how AvB3 integrin signaling could be mediating fibronectin matrix assembly in TM cells 3611 387 6714 PMC6753173__F4 A schematic diagram of pathogen-derived molecules used to escape intracellular DNA sensing pathways 9447 51428 115004 29110 3661 3428 PMC6753173__F5 Schematic diagram of the pathogen-derived molecules used to escape cytokine-sensing pathways in cells 3716 7297 6772 6773 10379 83939 3454 3455 3437 PMC6753331__F1 MiR-155 is expressed in plasma (P), monocytes, fibroblast-like synoviocytes (RASF) and synovial fluid monocytes (SFCD14*C) of patients with RA/JIA 843 317 3661 7189 7099 3654 7097 6772 8651 PMC6753625__F1 Common signaling pathway for IL-1 family cytokines 27179 90865 7189 3554 6761 PMC6763828__F9 Schematic model of intracellular signal components that control S-phase entry in vestibular epithelia from neonatal mammals 759 2064 5266 PMC6769927__F2 Transforming growth factor B (TGFB) family SMAD-dependent signaling 7040 7042 7043 650 655 654 8200 4838 7048 659 92 93 4087 4086 4088 4090 4093 6662 860 PMC6769927__F4 The different Transforming Growth Factor B (TGFB) family members on articular cartilage biology and osteoarthritis (OA) development 10216 6662 11096 4314 4090 4086 4087 4088 4322 249 860 3569 6774 PMC6780497__F4 Enriched extracellular matrix organization pathway in non-type subtype of bladder carcinoma cell lines 3672 3688 7076 3909 3678 3915 3383 5351 5033 5352 3911 4684 871 1508 2335 3694 1509 2200 PMC6782198__F7 Postreceptor adaptations of the cAMP pathway observed in response to chronic antidepressant treatment 5141 5142 627 PMC6784043__F1 Novel insights into the dectin-1 signaling pathway 6850 868 5894 55223 5336 64170 8915 10892 4843 PMC6785123__F5 Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma 89 9863 81 87 4118 8573 2534 4690 88 8440 4868 5290 5296 5295 23607 8976 PMC6787681__F4 AT-rich interactive domain 1A (ARID1A) chromatin remodeling abnormalities in ovarian clear cell carcinoma (OCCC) 8289 2146 4609 2475 1026 PMC6789122__F7 Proposed model for the role of RarA in adrenocortical development 54361 7422 51176 6256 5914 1585 1499 6929 PMC6790052__F1 Ciona robusta cardiopharyngeal gene regulatory network and tunicate phylogeny 400410 9705 6768 6767 PMC6794464__F2 Scheme of differentiation of M cells in PP 2813 6689 30812 65108 308 7189 7127 5970 5971 6364 PMC6796468__F5 Proposed model of PYCR1 interference on HCC cell proliferation and apoptosis 5831 3725 3667 PMC6797571__F2 Platelet‐derived growth factors from breast cancer or neuroblastoma stimulate the platelet‐derived growth factor (PDGF) receptors and initiate immune and tumorigenesis response 7099 54106 7098 57092 572 638 PMC6797860__F1 Receptor composition of IL-12 family members and related cytokines 10148 3595 3594 149233 6775 6774 6772 3416 PMC6797978__F6 Schematic representation of the effects of TAGLN2 on breast cancer metastasis 8407 5052 4312 4313 7852 PMC6799818__F5 Additional gut microbial metabolites regulate host immunity and metabolism 196 1499 7473 64806 3553 PMC6800568__F1 Innate immune mechanisms in SLE 3627 3553 1776 115004 54106 51284 11277 4615 51135 PMC6800950__F4 SREBP pathway mediated NLRP3 inflammasome activation 22937 114548 3603 PMC6801787__F1 Schematic illustration vitamin D synthesis pathway and signalling mechanisms relevant to PAD formation 5212 1628 1593 1594 PMC6801800__F6 Endogenously derived chemerin mediates a tumor-suppressive effect through inhibition of Wnt/Beta-catenin signaling in adrenocortical carcinoma 324 2932 1499 PMC6814307__F1 Vitamin D metabolic pathway 120227 1591 5741 1594 8074 PMC6824835__F2 AKAP5 and AKAP12 in modulating oxidative stress in cardiac cells 9495 7040 7048 7046 4087 4088 9590 PMC6826302__F2 Mechanisms mediated through IGF-1/IGF-1R 3486 3480 3479 3667 PMC6830079__F1 Cyclic GMP AMP synthase-STING (cGAS-STING) pathway signaling as activated by genomic instability 115004 3661 5971 29110 5970 PMC6831300__F8 Hypothetic model of signaling pathways involved in the differentiation of hiPSC-CM from mesodermal progenitors 324 2932 1499 PMC6832683__F10 Schematic diagram illustrating the distinct roles of Nrp2 in corticostriatal pathway development, maintenance, and function 8828 2115 6693 PMC6838365__F40 Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3B/Beta-catenin signaling pathway 6416 4627 7189 2932 1499 PMC6842984__F1 Diagrammatic representation of known mechanisms of action of lithium in endocrine cancers 581 596 2932 3164 1499 7849 6899 PMC6843035__F5 Phosphoinositide signaling pathway in renal collecting duct cells 3708 3710 8394 23396 5297 5332 5298 5581 5583 5029 5587 PMC6850186__F6 How ablation of IKBNS affects B cell activation and PC differentiation 613 7099 5970 PMC6851151__F1 Current translational potential and underlying molecular mechanisms of necroptosis 3466 11035 197259 PMC6851170__F9 The anti-TGEV effect of Lp-1s 3454 3455 3716 6772 4600 8638 9636 PMC6854591__F8 PH-EPS modulates the activation of RAW264.7 cells through the TLR4(Dectin-1)/NFKB/MAPK pathway 114609 4615 7124 PMC6854988__F12 The GO interaction network of coexpression genes (the cnetplot of coexpression genes from MF enriched pathway) 6256 5465 196 6258 PMC6856869__F4 Recognition of HSV-1 infection by pattern recognition receptors (PRRs) 7097 115004 3665 3661 3428 PMC6856883__F1 Regulatory roles of lncRNAs in TAM polarization 101929244 6774 378938 PMC6858087__F1 Structural variability in the RLR-MAVS pathway and sensitive detection of viral RNAs 1283 57506 7186 7189 7188 3661 PMC6861014__F7 Model depicting the regulation of the host cellular response to systemic LM infection by C5aR1 and C5aR2 728 27202 51428 PMC6862839__F4 Toll-like receptors (TLRs) in Lamellibrachia luymesi 4615 3654 51135 PMC6867841__F7 Schematic picture depicting the effect of the immune factors on cysticercal brain infection 3606 7185 7187 7186 PMC6868851__F3 Mechanism of miR21 in PC development 27250 5728 2475 572 PMC6879750__F5 Conserved and novel homologues of bilaterian genes involved in axis patterning and regulated by the Wnt/Beta-catenin signalling pathway in Hydra 2932 1745 170302 3195 7080 23440 2078 51176 11063 2625 338917 4010 58524 79190 27023 860 1499 PMC6880815__F3 Putative biosynthetic pathway to the nanangenines 100306940 2160 2159 PMC6881418__F3 Roles of CAFs in drug resistance 3082 56034 6387 387923 PMC6889001__F2 Atherothrombosis and the NLRP3 Inflammasome – Endogenous Mechanisms of Inhibition 7099 5763 114548 23410 3606 PMC6889404__F1 hnRNPA2B1, an RNA-binding protein, can function as an m6A reader and is involved in RNA transport, processing or splicing 3661 29110 115004 3428 3181 23210 79068 PMC6890986__F3 Mitochondrial apoptosis pathway 637 638 572 8739 90427 581 PMC6895449__F7 Illustration of the NEK2/Beta-catenin/Myc/KDM5B/H3K4me3 pathway 4751 1499 10765 10873 PMC6896241__F1 Representation of causal interaction data in a standardized format 6608 374654 2736 79923 4609 PMC6896486__F7 Exacerbation between G6PD dysfunction and neuroinflammation mediated chronic neurodegeneration 2539 7124 7099 PMC6898841__F5 The schematic presentation for the signaling of the top 3 kinases crucial for cardiomyocyte survival 3480 3479 2475 PMC6900528__F6 The proposed pathway of IPs synthesis 253430 3705 51477 PMC6901313__F11 Conceptual framework of BCL-xL expression during persistent LPS senescence induction 581 4893 2113 PMC6904658__F2 Probable immunoregulatory mechanisms mediated by gut microbiota as a consequence of faecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD) 196 7097 50943 920 3586 PMC6906806__F10 The summary of the signaling pathway of TRPC3 upregulation in fibroblasts involved in fibrosis 7222 4087 4088 387 PMC6909602__F6 Schematic of the mechanism by which Alpha-synuclein induces the accumulation of microglia through CXCL12/CXCR4 7852 6714 6387 7099 4790 PMC6914882__F10 Schematic representation influence of PCr against DCM on Bcl-2 family members and other mitochondrial apoptotic and metabolic proteins in cardiomyocytes under various pathological conditions 3717 596 6774 836 842 PMC6915928__F2 The results of protein-protein interactions were identified with STRING database 951 4063 29851 3702 962 9595 9744 5788 29760 6504 916 3683 959 4261 3957 917 9402 939 7454 4050 1439 7253 5579 164668 55843 81793 PMC6917045__F3 Control of proteostasis by the ufmylation pathway 51569 51506 6154 23376 7018 PMC6925523__F3 Cellular signalling pathways in response to pathogenic viral infection or mtDNA release 57506 3661 3665 54106 114548 115004 PMC6930809__F12 Potential mechanisms by which Meisoindigo protects against focal cerebral ischemia-reperfusion injury (CIRI) 3553 114548 7099 929 PMC6932876__F1 Mechanisms of ADSCs differentiation into SMC and EC 387 4087 4088 9439 2002 6722 PMC6933576__F11 Apoptotic pathway and targets for complexes 1, 2, 3, and 4 637 841 842 836 PMC6935412__F3 Increased IFNB enhanceosome components in lupus B cells 7098 54106 51284 613 4615 115004 3665 3661 6773 6772 3454 3455 PMC6935452__F2 Canonical and noncanonical Notch signaling pathway 1499 6476 256933 26508 23493 23462 PMC6937575__F5 The CD38/cADPR/NAADP-signaling pathway 952 10519 23098 PMC6939687__F2 Interplay between HIF-1A and Notch during hypoxia 1356 441478 6657 10135 PMC6939831__F4 Three enriched Ca2+-related pathways 857 8321 5159 6262 2317 2885 1616 489 5519 324 4088 4089 PMC6941088__F2 The classical and alternative nuclear factor-KB (NFKB) signaling pathways 3553 4050 5971 PMC6941304__F1 Models of Siglec-15–ligand interaction and downstream signaling 960 6850 7189 PMC6942368__F7 Role of liraglutide in regulating hCMSC paracrine and SPC expression 1499 6925 2255 PMC6943569__F4 Activation of NF-кB by the canonical and/or the noncanonical pathway 5971 5970 5966 PMC6944044__F2 Linc00152 is involved in protein activation 1956 4691 672 5728 PMC6944604__F2 The roles of ADAR1-mediated RNA editing in Multiple myeloma (MM), basal cell carcinoma (BCC) and medulloblastoma (MB) 51684 2735 1859 79661 PMC6947386__F2 Cellular calcium [Ca2+] homeostasis and signaling: Organelles and molecules that are involved in Ca2+ pathways 6786 84876 7222 7224 90550 PMC6947889__F7 Induction of pyroptosis via ER stress and the effects of SIRT1 on this process 23411 83939 468 PMC6948255__F6 Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1 1499 595 4314 100316868 6422 PMC6949840__F3 (1) TNFA, and IL-1B can induce the expression of TGFB 1636 3603 7421 4087 4088 4089 PMC6949885__F15 Molecular mechanism by which miR-601 downregulation inhibits the proliferation, migration and invasion of PCSCs by activating KRT5, and subsequently inhibiting the Wnt signaling pathway 7471 2932 1499 693186 79923 PMC6952538__F1 RORGt functions play a central intermediary role in linking the control of cholesterol biosynthesis and metabolism to the regulation of immune responses and autoimmune disease 8648 196 9611 3065 PMC6954088__F8 The proposed mechanism for AAV9-shMyh9 against I/R-induced neuronal injury 4280 6093 581 PMC6954967__F3 Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2 775 3708 4659 5138 5332 4209 PMC6955051__F3 Role of interleukins in heart failure with reduced ejection fraction 90865 6761 4615 3656 7054 7412 3383 PMC6955127__F6 Effects of AMI (92 mg/ml) on the mechanism of Raw264.7 cells infected with influenza virus 7098 29110 3661 PMC6963216__F2 Cascade of events that leads to interferons (IFN) mediated antiviral response 6772 3716 7297 3454 6773 57506 10379 3659 29110 3661 PMC6966455__F8 Signaling pathway involved in GR cells with ROCK2 inhibition 9475 6667 6935 PMC6973012__F1 Molecular mechanisms in allergic inflammation 85480 64806 90865 4155 7124 8178 PMC6977532__F2 Sepsis on AHR and inflammatory factors 6714 6774 196 3553 7099 PMC6977534__F2 Roles of zinc transporters in B cells of different stages 613 57181 4067 7922 PMC6977602__F5 FSS regulating osteoclasts bone resorption function via ERK5 signaling pathway (green arrows are positively adjusted; red arrows are negatively adjusted; red lines are decreased due to inhibition of upstream proteins) 4318 1513 4772 100187907 PMC6983837__F10 RIG-I activation in the context of influenza infection 1283 7706 57506 3661 PMC6988322__F5 SMARCD1 nearest-neighbor adjacency subnetwork with the glucocorticoid receptor response pathway 6446 2033 1387 6602 6599 1356 2908 6601 6597 PMC6991676__F7 Hypothetical pathway related to the disease pathogenesis process 7157 4609 1026 5925 PMC6996149__F4 Major cholesterol metabolic pathways in brain 8213 10858 9023 1593 9420 80270 PMC7004353__F9 Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development 55902 216 51109 157506 9227 1545 22937 3479 PMC7004529__F2 Biological function of senescence‐associated secretory phenotype (SASP) factors in physiological and pathological conditions 2919 6347 6352 PMC7004529__F3 CGAS‐STING pathway in senescence‐associated secretory phenotype (SASP) regulation 3661 115004 29110 PMC7010080__F2 NAD+ in cancer metabolic reprogramming 22933 2539 2936 3558 23411 51548 2597 23410 PMC7011072__F3 Curated interactions for HES1, NOTCH1, and TNFA genes using SIGNOR database 7124 4851 904 9641 5468 2908 1869 1385 3516 PMC7011253__F1 Schematic diagram of Chinese medicines direct and indirect regulating NFKB pathway in UC treatment 7099 4615 1636 6774 PMC7013859__F2 LPS recognition by toll-like receptor 4 (TLR4) 3929 929 7099 4615 3661 PMC7016717__F3 Oncogenic activation of the STAT3 pathway in T-cell lymphoma 3716 3718 6774 PMC7016858__F1 Biogenesis and heterogeneity of tumor-derived extracellular vesicles 967 928 975 3732 4827 27161 PMC7016950__F8 Schematic outline representing neuronal adiponectin signaling pathway in the brain upon consumption of HFD 4025 51094 6855 3606 2670 PMC7016982__F1 Regulation of YAP at the level of the extracellular matrix involves various proteins involved in stabilizing and activating YAP 10611 9260 6714 PMC7017752__F3 Emerging therapeutic targets for neurofibromatosis type 1 (NF1) 4763 3815 1435 1499 PMC7019991__F2 Representative image describing the role of the NOTCH/JAG1 pathway in AML-MSCs of a model describing MSCs in human BM niche 947 182 4254 3280 PMC7022928__F1 Retinoic acid signaling pathway 5950 64220 9227 1382 PMC7023715__F7 Activation of the PDGFRAlpha-Nrf2 anti-adipogenic signaling pathway impairs adipocyte differentiation in Nck1-deficient BM-MSCs 5156 4690 3162 PMC7028093__F2 Notch signaling pathway 182 3714 4855 4853 4851 4854 3955 8650 55534 84441 9794 3516 PMC7028855__F2 miR212 and Hedgehog pathway 6469 6608 374654 51684 5727 2737 2736 PMC7033839__F1 Proposed mechanism of statins, colchicine, and aspirin on the reduction of radiation‐associated cardiovascular disease (RACVD) 3569 3565 3596 6010 PMC7037145__F3 Conflicting role of JNKs in dermal fibroblast biology 1277 1278 1896 PMC7047114__F6 NFKB-pathway 7099 4615 3654 51135 7189 2745 PMC7048264__F7 HIF-2A regulation via DDX28 55794 5936 8672 PMC7052781__F2 Metabolic coordination of macrophage activation 3458 948 7099 PMC7054735__F1 Therapeutic approaches for osteogenesis imperfecta 9242 4041 1499 50964 PMC7056705__F2 Major mechanisms underlying induction of the host immune response by VPM1002 and M 3553 9447 115004 PMC7057844__F2 Molecular Mechanism of Runx2-Dependent Bone Development 860 2735 6932 5727 5745 2263 2261 121340 5744 PMC7060471__F1 A, Position frequency matrix of the T‐cell factor (TCF) motif was obtained from the JASPAR database (http://jaspar.genereg.net) 1499 3034 7018 PMC7061741__F7 Schematic diagram showing putative targets and small molecules specific to the Hippo pathway 154796 9113 26524 PMC7066027__F4 Roles of miR-30c family members in carcinogenesis, metastasis and invasion 5756 3845 7431 PMC7070171__F8 Schema showing the major roles of butyrate in inhibiting atherosclerosis of mice in this study 9619 6667 641371 10965 123 440503 8876 6517 2645 1581 10113 PMC7072285__F6 Putative inhibitory effect of 8-HD in the IRF-3 signaling pathway 7099 3627 3434 114609 4615 7187 29110 3661 PMC7081551__F1 Summary diagram of miRNAs, lncRNAs and circRNAs participated in the drug resistance of gastric cancer 693122 57291 378938 693208 PMC7082880__F5 Drugs targeting Wnt pathways in cancer treatments 7474 8549 5754 4041 4040 84133 54894 1499 PMC7086007__F3 NLR signaling pathways in diabetic nephropathyThe NLRP3 inflammasome can be activated by the ROS/TXNIP/NADPH oxidase signaling pathway and extracellular ATP, and inhibited by IL-22 114548 50616 3553 10392 64127 10628 84166 64170 58484 PMC7097117__F1 ISG15 in antiviral immunity and beyond 9636 3455 3454 163702 7099 3716 7297 115004 10379 57506 29110 3661 3665 1387 11274 55008 51191 7706 25820 PMC7097117__F4 ISG15 in antiviral immunity and beyond 9636 11274 51191 7706 55008 PMC7099013__F2 Ingenuity pathway analysis of drug pharmacodynamic targets, associated immunophenotype markers and topo II 3123 2857 6320 8412 55576 PMC7102037__F2 Hyperglycemia-induced lung diseases 6010 6774 435 PMC7106955__F3 Hippo signalling pathway 790 4771 7018 2012 7037 2182 50507 PMC7108857__F10 Working model of FMDV 3A regulation of the G3BP1-mediated RLH signaling pathway 126364 10146 7189 29110 3661 PMC7109323__F6 Inhibition of PRRSV by LPS 9332 6868 7099 PMC7118073__F7 Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression 51506 2146 5728 PMC7120249__F1 Immune-related autophagy functions 7099 64127 55054 3553 345611 PMC7122459__F1 Molecular signaling pathways involved in astrocytogenesis 650 1270 3976 3977 4774 6662 PMC7123827__F4 3 signals of T-helper cell activation 920 324 941 940 942 PMC7136166__F1 Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease 3492 5741 3479 PMC7136955__F1 Cancer‐associated fibroblasts: activin A adds another string to their bow 4087 4088 4089 PMC7137032__F2 Current paradigm of asthma endotypes and related therapies 64806 90865 85480 PMC7141330__F2 Hepatitis C virus (HCV) sensing by the intracellular innate immunity throughout the virus life cycle 7098 57506 29110 3661 3659 3716 7297 3717 10379 PMC7142266__F2 Mechanisms of tumorigenesis attributable to FA mutations 2177 672 2178 545 1111 2175 55120 55215 2176 2188 PMC7146376__F2 Location of CYP27B1 activity in the metabolic pathway of vitamin D (based on Jenkinson 2019 and Feldman et al 1717 1593 120227 1576 1591 1594 7421 PMC7150840__F1 Simplified scheme of the Wnt/Beta-catenin signaling pathway 324 2932 1499 4040 4041 50964 PMC7151139__F1 BMP signaling pathway 4091 4086 4090 4089 PMC7158602__F7 The functions of OMT on inhibiting NP cells inflammation 3146 3603 7099 54472 7189 4615 PMC7160658__F1 Checkpoint inhibition‐induced adverse events 324 941 942 940 PMC7162614__F6 Adding MASP1 to the lectin pathway—Leprosy association puzzle: Hints from gene polymorphisms and protein levels 8547 7038 1378 100422910 100422972 PMC7164247__F8 Proposed model for antigen presentation by astrocytes in the PD brain 920 941 942 3916 PMC7167007__F1 Interferon signaling pathway 7099 3455 3454 7297 29110 6773 3661 10379 PMC7170511__F16 Models for RHAMM-regulated motogenic signaling in keratinocytes and temporal-spatial coordination of keratinocyte and fibroblast migration in excisional wounds 960 1956 4318 PMC7170981__F5 Evaluation of genes regulated by butyrate in controls and patients with UC 959 1437 3558 3552 114609 7132 6097 6772 6347 148022 5290 7189 6778 3551 5970 331 1234 941 3554 50943 3586 7100 3569 6352 3576 3627 3383 4790 3133 3717 114548 54106 3606 330 8737 54472 5606 3661 PMC7175146__F2 Structure of the neurovascular unit (NVU) with particular attention to the glucose metabolism impairment 361 1003 6285 PMC7177758__F1 JNK (C-Jun N-terminal kinase) substrates that regulate the mitochondrial apoptotic pathway 572 90427 83737 PMC7180799__F6 Proposed signaling pathways for the protective effect of LPA against simvastatin-induced cytotoxicity in L6 cells 4018 2475 572 596 PMC7185105__F9 Hypothetical scheme of molecular and cellular events in the cochleae of aging Tg-B1 mice leading to accelerated hearing loss 2475 8408 8678 PMC7185212__F2 CD8 T cell linear differentiation model 1236 324 8320 6932 864 2308 940 1878 3558 10538 3458 PMC7198830__F1 Direct cardiotoxic effects of anti-cancer therapies in cardiomyocytes 2064 2066 6714 572 2475 PMC7202972__SF1 Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice 3717 6777 2690 2311 PMC7206068__F5 TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses 9097 9830 115004 7098 7099 29110 373 22954 6737 8887 3661 3458 10475 4615 114609 PMC7216265__F4 Cancer glutaminolysis pathways through circRNAs 2744 100302155 8078 1499 3481 PMC7218278__F1 “Confidence view” of the protein-protein interaction network on String.The thickness of the blue line between 2 nodes indicates the level of confidence of association between these 2 8639 2101 7305 3937 3936 1051 5468 90865 5911 5966 80341 9021 8837 6670 29956 PMC7222158__F2 Gene network of positive regulation of fat cell differentiation (obtained using Pathway Studio v 5919 6423 5743 3624 PMC7223841__F4 NAD+ homeostasis in renal health and disease 125061 8564 8942 23498 130013 23475 PMC7225294__F11 Proposed model of action and mechanism by which CVB3 infection causes cardiomyocyte death 1499 9636 57506 3456 1829 1824 PMC7226820__F3 Main signaling pathways involving LSEC during liver regeneration 3082 7472 4851 7484 PMC7227813__F2 Anti-lipolysis regulation by insulin on the morphological differences of adipose tissue 3667 8660 5140 PMC7230029__F1 Chromothripsis and telomere crisis: engines of genome instability 115004 29110 11277 3661 PMC7232267__F5 Micro ribonucleic acid (miRNA) cross‐talk between miR 29 and miR let‐7 in the anti‐endothelial mesenchymal transition action of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline (AcSDKP) 1803 2260 4088 7046 PMC7241820__F8 Long noncoding RNA PAHAL modulates locust behavioural plasticity through the feedback regulation of dopamine biosynthesis 5053 6427 3034 PMC7243420__F2 From Beyond the Pale to the Pale Riders: The Emerging Association of Bacteria with Oral Cancer 2308 9839 51701 PMC7247696__F2 TLR-4 Signaling vs. Immune Checkpoints, miRNAs Molecules, Cancer Stem Cells, and Wingless-Signaling Interplay in Glioblastoma Multiforme—Future Perspectives 29110 5929 27122 PMC7248199__F7 Putative pathway showing regulatory relationships of key genes to NFKB activation transcriptionally regulated by NLRC5 6352 7100 3567 3558 841 3665 6774 3717 51284 834 9516 2625 PMC7248300__F2 HCMV encoded proteins which help to evade CD4+ T cell mediated immune responses 920 115004 4261 1616 PMC7249691__F8 Schematic diagram illustrating the different in canonical versus non-canonical response to IL-12 6775 3595 3594 7297 3717 PMC7254133__F7 Model representing the hetIL-15 triggered pathway for tumor infiltration by lymphocytes and dendritic cells 2833 4283 2829 3394 3458 6375 PMC7263313__F4 Targeting senescent cells to attenuate cardiovascular disease progression 11277 1777 115004 PMC7267026__F2 RLR signaling pathways 57506 7186 7187 7189 7188 3661 3665 PMC7268158__F1 JAK/STAT System 3565 3596 2056 3458 4352 7297 6775 3717 PMC7268922__F3 Function pathway analysis between COPD and the two genes: CD38 and TNFRSF12A 2064 387 7040 3596 1950 2247 3458 3569 51330 3553 7124 9365 3146 3558 952 1432 7226 23411 2309 836 PMC7269823__F3 Changes in extracellular matrix (ECM), focal adhesions, and integrin signaling in ADPKD 673 5894 4052 4087 4088 3611 2475 387 PMC7270498__F1 ncRNAs Affect Drug Efflux and Nrf2-Dependent Drug Metabolism in HCC CellsVarious miRNAs and lncRNAs can regulate intracellular drug concentrations in HCC cells by targeting drug efflux pumps 3479 441094 100124700 283120 3480 9817 1719 664612 442908 128071539 8178 PMC7272438__F8 Proposed model for the involvement of miR-199a-3p and CAV2 in hepatic fibrosis 7046 7048 858 4087 4088 PMC7278761__F3 Schematic presentation of interactions between nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NFKB) transcription factors 100188864 7054 3569 PMC7279331__F3 Calmodulin and protein kinase C (PKC) modulating critical features of KRas-driven tumourigenesis 5879 5894 596 PMC7283439__F7 FG-4592 activity on depression 2056 627 9456 PMC7284105__F2 Feed-forward autocrine YAP activation 81788 1956 2065 3084 1839 5155 PMC7284145__F7 Biological pathway related to TMPRSS2 predicted by KEGG 5328 5327 7113 2078 6935 7018 7850 2115 6692 2118 2119 PMC7290932__F5 Models for release of the Xenopus oocyte prophase block: probable cooperation between several receptors and downstream pathways 3479 3480 4342 PMC7290982__F1 GD T cells activation 324 3652 4277 100507436 940 PMC7291472__F1 Diagram of CD155/CD112-mediated immunoregulatory pathway on NK cells 10666 10225 201633 PMC7294406__F4 Gene product interaction network of “InterferonG” gene set—an up-regulated pathway in subcutaneous fat of OSA subjects relative to those without OSA 3458 8743 355 836 6772 841 6774 PMC7296156__F3 Biological properties of cmvIL10 in myeloid progenitors (during lytic infection) 920 8833 929 3135 7852 6774 PMC7297305__F4 LncRNA-miRNA-mRNA network for human primed, naive and extended pluripotent stem cells 100505881 5159 7039 81029 PMC7299245__F1 Targets of new therapeutic options in beta-thalassemia 9573 2662 10220 2657 60 4087 4088 4089 2056 3717 654 3077 148738 7036 4090 4086 6774 57817 151176 PMC7304430__F12 Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research 3667 8717 7186 PMC7307344__F1 LncRNAs in osteosarcoma via PI3K/Akt signaling pathway 378938 80307 100287616 5820 138948 PMC7311749__F1 Multiple oxidative stress factors induce pneumonia and AMPK-Nrf2 pathway inhibits pulmonary ROS accumulation 260431 2309 7351 1728 PMC7312033__F2 IL-33, as pro-inflammatory and regulatory, on the central nervous system, liver, cardiovascular system, and pulmonary system 90865 471 3654 7189 3567 4615 PMC7312541__F1 Canonical Wnt/Beta-catenin pathway 4040 4041 2932 324 1499 PMC7312833__F4 Interleukin (IL)-6/Grp130-JAK-STAT signaling pathway 7046 7049 4087 4088 6774 2309 9021 PMC7312833__F6 Functional relationship between GFAP+ (glial fibrillary acidic protein) reactive astrocytes and IBA+ (ionized calcium-binding adapter molecule) activated microglia 2833 3627 7099 3146 367 718 3934 2670 54209 PMC7313089__F2 Involvement of ubiquitin in the key signaling pathways important for IFN production and IFN responses 57506 115004 1081 10010 29110 3661 PMC7317437__F5 Proposed schematic diagram of signalling pathways for doxorubicin‐induced muscle atrophy 2660 3479 3667 4087 2475 664 PMC7320018__F6 Possible roles of TBC1D9 (A) and MFGE8 (B) 4240 7291 6774 6400 10956 3091 PMC7322393__F1 Zoledronic acid (ZA) acts as immunostimulant and endosomal disruptor of dendritic cell in SARS-CoV-2 infection 909 941 9308 3652 942 PMC7327052__F3 Centrosome aberrations trigger an immunosuppressive microenvironment 324 115004 51129 29110 PMC7327642__F8 Mechanism underlying Notch ability to promote drug resistance in multiple myeloma (MM) microenvironment 79258 1878 8178 3280 596 7852 PMC7330089__F8 Regulatory model of the MBW complexes for juvenile red fading in sweetpotato leaves 4602 717 718 727 PMC7330533__F2 Network pharmacology of targets of anemoside B4 against pneumonia 841 836 7040 842 4790 7124 PMC7334537__F1 Steroidogenesis including the classic androgen pathway (dark blue) and the alternative androgen biosynthesis pathway (light blue), both resulting in the synthesis of potent 5Alpha-dihydrotestosterone (DHT) 5447 1589 1586 6715 1588 6716 PMC7335506__F2 Therapeutic targets on the interleukin‐1 pathway 3554 3556 4615 7189 3553 7850 7808 PMC7339106__F3 Tumor expressed CD200 inhibits the expansion of myeloid cells in TME 4345 4280 8205 PMC7339185__F12 Regulation mechanism of miR‐128‐3p in BCSCs 4751 1499 100133941 960 90780 79923 1956 58191 PMC7341846__F5 Alterations to the kynurenine pathway in RCC 6999 125061 883 56267 8564 8942 169355 3620 23498 23475 10135 PMC7346528__F1 Hedgehog signaling pathway 6469 3549 8643 5727 2735 2736 2737 51684 374654 1859 PMC7348953__F1 Therapeutic Targeting of the Wnt Signaling Pathway 8658 2932 324 64840 1499 4040 4041 PMC7349579__F2 Interactions of LCSCs influencing HCC 6774 3569 4040 4041 920 100133941 961 324 4072 4089 4087 1499 PMC7349809__F1 Mechanisms for respiratory syncytial virus (RSV) inhibition of type I interferon (IFN) production 3454 3455 57762 3716 23586 7297 57506 7187 10010 29110 3661 3665 10379 6773 6772 PMC7349823__F7 Distinct mechanism of miR-210 in the regulation of mouse and cattle adipogenesis 6925 23090 1499 PMC7350219__F1 Cytosolic DNA sensing and pathway activation 115004 3661 29110 7189 PMC7352357__F1 Cholesterol metabolism and key oncogenic pathways related to cancer development 3156 6713 7157 3949 5728 6608 2735 38 255738 6774 3638 114548 22937 PMC7352727__F7 KRAS promotes glycolysis, protein and lipid synthesis and one carbon pathway 3845 2475 10840 PMC7354440__F8 PEDV nsp15 antagonizes host antiviral response by degradating the RNA levels of TBK1 and IRF3 23586 57506 29110 3661 PMC7356105__F2 Illustration depicts the localization of the gene products by cellular compartmentalization and indicates the downregulated expression of NF-kappaB signaling pathway as an effect of vitamin E formulation treatment on heat killed C 1950 4803 7039 4049 114609 7186 PMC7363530__F1 Genetic pathways in nonalcoholic fatty liver disease (NAFLD) 338 4547 7038 2646 53345 80339 51099 345275 PMC7367617__F3 KEGG enrichment of 249 DEGs identified between chemotherapy sensitive and insensitive OC 4137 2353 3725 1839 10912 7124 2920 2921 4049 9021 PMC7369905__F4 NRF2 regulates inflammation and immunity 7124 941 3603 942 8685 PMC7370155__F2 HMGB1-mediated EBI post-SAH 3146 7097 7099 4615 3717 114609 6774 7189 PMC7372134__F2 Hmox1 transcriptional regulation 9817 2932 571 3162 4094 3091 PMC7385848__F1 Bile acid metabolism pathway.Two major pathways are involved in bile acid synthesis 1581 80270 1582 6718 1109 1593 PMC7387202__F1 IGF system and its components 3485 3484 3480 3486 3482 3488 3489 PMC7388440__F6 RA pathway model 7474 2932 4919 1499 PMC7389686__F1 Proteins associated with LGMD and other muscle diseases such as DMD 84892 10585 29954 60684 55624 79912 PMC7393488__F7 LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-кB signaling pathway 4615 51135 55298 51176 PMC7395694__F9 Model for miR-214 regulation upon CC cell progression 3717 6774 5753 6722 PMC7395767__F1 Old dogs, new trick: classic cancer therapies activate cGAS 29110 3661 115004 PMC7397420__F12 Demonstration of the putative mechanism of action of lithium in the NFKB signalling pathway 23118 8945 7189 3654 205 114609 PMC7397772__F1 Apolipoprotein E (APOE) exhibits both proinflammatory and antiinflammatory properties 348 3949 4615 114548 6374 3553 7099 PMC7400846__F2 Cholesterol and bile acid biosynthesis 6668 6667 22937 3949 39 3638 51141 126669 64241 64240 8647 PMC7403459__F1 Two primary pathways produce ceramides in cells: (a) de novo synthesis (b) re-acylation of sphingosine (salvage pathway) 29956 204219 79603 91012 PMC7403467__F1 Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll 5132 4615 54106 3458 920 3565 3586 PMC7404143__F3 Endothelial cell NRP2-mediated signalling pathways 7422 51129 7046 8828 4087 4088 6237 387 PMC7404291__F4 HSV-1 evasion mechanisms to downregulate the host innate immune response 4615 7297 3716 7189 115004 6772 57506 7187 3665 3661 6773 10379 7097 PMC7407594__F2 RNA sensing mechanisms 8635 6036 7098 51284 51311 4615 3661 3663 4938 3434 6041 PMC7407770__F4 Possible approaches for MASTL therapeutic targeting and the expected biological outcomes from each strategy 84930 2029 10776 PMC7408653__F1 Wnt Signaling Pathway Activation and Inhibition 1499 2932 324 PMC7411728__F2 Inflammation, innate immunity, and adaptive immunity by CH25H and 25HC 9023 3553 3606 7124 PMC7412691__F6 Schematic diagram of the mechanism underlies miR‐155 function in chondrocyte apoptosis and catabolic activity 3553 5295 4322 4314 PMC7414267__F2 Pro-viral and antiviral roles of TRIM6 117854 3454 3455 8673 7706 57506 6773 29110 3661 7297 3716 PMC7418153__F1 An overview of Wnt signaling pathway 54894 84133 259266 59349 324 2932 8549 1499 4041 4040 PMC7423683__F4 Notch and the Regulation of Osteoclast Differentiation and Function 4851 4854 4853 3553 3280 PMC7423897__F3 Overlap of identified miRNA targets with pathways related to the pathogenesis of atherosclerosis 51330 958 8764 7018 729230 1232 7852 PMC7426728__F1 Activation of the Wnt/Beta-catenin signaling pathway in the resistance to therapy in cancer by methylation 4040 4041 2932 324 1499 27122 6422 11197 PMC7427806__F4 New preclinical models for angioimmunoblastic T-cell lymphoma: filling the GAP 54790 387 920 29851 PMC7433199__F3 Signaling pathways other mucins involved in non-small cell lung cancer 2932 3717 4313 595 6774 4318 5111 4583 100507246 4586 4585 25803 63976 1956 PMC7433927__F1 Interrelationships among components of the 1-carbon metabolism pathway (Methionine cycle, Folate cycle, and Transsulfuration pathway) 2475 6723 6611 635 4548 4552 875 157739 1491 7298 1719 10841 PMC7437079__F3 STAT3 pathway and IL6/STAT3/S1PR1 amplification loop in IBD-CRC 9021 1901 6774 50616 3569 PMC7438927__F8 Networks of an unreported AA-specific/enhanced DEG (CHRNE) 8785 1311 434 10216 7060 3075 57817 4922 221391 1271 5913 1356 1145 9254 91937 199920 776 794 PMC7441816__F2 PVAT regulates VSMC dilation and contraction 875 10278 183 5228 27035 PMC7443136__F8 TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury 1277 114548 79792 7099 4615 PMC7443512__F2 Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission 3553 7124 114548 51311 51284 7098 4615 834 3661 3665 PMC7444278__F3 Major components of the vertebrate Hedgehog pathway are dynamically localized to the primary cilium in response to Hedgehog ligand 5727 6608 51684 374654 7289 23432 PMC7448212__F6 Mechanism by which MCL attenuates the inflammatory response of NRK-52E cells 114548 8011 3553 834 PMC7452060__F1 circSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small-Cell Lung Cancer by Targeting the miR-520h/ABCG2 Pathway 6426 84193 574493 9429 PMC7453787__F4 Crosstalk between inflammation and the BMP-SMAD pathway in hepcidin regulation 650 654 148738 659 92 93 57817 3717 6774 PMC7457047__F1 Drugs and antibodies that affect the function of the neuromuscular junction 100170220 43 4038 8292 4593 285489 PMC7457384__F1 Source of IL-33 and the IL-33/ST2 signaling pathway 90865 6761 4615 PMC7459397__F1 FGF18‐induced ER‐phagy in chondrocytes 8817 2261 2264 3667 7942 PMC7460634__F2 Semaphorins in adipogenesis 56920 2932 10371 PMC7461207__F3 Mechanotransduction signalling for osteogenesis of human mesenchymal stem cells (hMSCs) 59341 650 4086 2353 860 PMC7464452__F2 Possible endothelial–mesenchymal and epithelial–mesenchymal interactions in BPD-PH 2247 574506 494336 2260 2263 6469 2255 PMC7464713__F7 Implemented model of the Wnt-independent Beta-catenin pathway 847 64321 1499 6925 PMC7465818__F1 Canonical NFKB pathway can be activated via multiple different ligand/receptor interactions 613 958 5971 PMC7466715__F3 Signaling pathways of TGFB and Wnt involved in joint pathophysiology 4041 4090 4086 1499 4087 4088 PMC7468896__F7 LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling 4088 60674 5494 PMC7470101__F1 Role of cytokines in mediating communication between immune cells 3569 9235 50616 55801 3458 3565 3596 3558 50604 3562 3600 246778 3606 3574 3586 3456 3567 11009 64806 59067 PMC7471098__F7 Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer 3845 138162 57761 468 PMC7472444__F6 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase 10891 5465 4975 3158 PMC7476571__F4 Viral miRNAs target genes involved in interferon signaling pathway 3454 3455 3459 3460 3716 7084 3717 6773 6772 23586 10379 3665 3661 PMC7479251__F4 Notch signaling pathway, including targets and drugs that could be employed to inhibit it 28514 10683 3714 182 54567 3516 PMC7479251__F5 Sonic Hedgehog canonical signaling, including targets and drugs that could be employed to inhibit it 51684 374654 2932 PMC7482219__F1 Mesoderm patterning by a dynamic gradient of retinoic acid signalling 2253 2249 1592 8854 4838 PMC7484393__F3 Correction: Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission 3553 7124 114548 51311 51284 7098 834 4615 3661 3665 PMC7491459__F3 Schematic diagram sketching three well-characterized pathways (3 vertical lanes) in which TGFB plays a role via signaling and/or transactivation/crosstalk and which may act to promote or prevent hypertension 1636 7040 11117 9392 1839 6868 1956 4088 4087 PMC7501057__F7 Intercellular fibrin networks prevent erythrocyte leakage 3383 7412 5340 5978 PMC7501262__F5 NLRP3 inflammasome in endothelial dysfunction 114548 574032 378938 55384 PMC7503245__F8 Schematic presentation of the possible role of bone kynurenic pathway activation in the osteoblast maturation process 468 595 632 50964 PMC7503576__F1 Bile acid synthesis pathways 1581 1593 9420 1582 25801 PMC7503925__F6 Pigment-type switching controlled by dual signaling from MC1R 434 4157 23295 4286 4151 8455 PMC7506081__F2 Sterol regulatory element-binding protein (SREBPs) mediate the uptake, efflux, and storage of cholesterol 3949 9619 355 22937 PMC7506081__F3 Sterol regulatory element-binding protein (SREBPs) is involved in the activation of M1-type macrophages 7099 4615 47 6348 6347 PMC7507121__F3 Tumor suppressor and promoting functions of TGFB signaling 3845 51129 7852 PMC7508719__F4 The KEGG “TGFB Signaling Pathway” showing differentially regulated genes for the Alizarin (+) treatments (TCPS_OS, PCL_NF, PDLLA_NF) 3397 3398 654 7058 1311 7057 4052 1634 10468 1030 PMC7509400__F2 Immune functions of GD T cells in cancers 3553 4277 100507436 355 PMC7509998__F1 Pathway activation of Notch signalling receptors and their downstream signalling molecules 182 3714 5045 PMC7514027__F6 Vanadium-protein complex inhibits human adipocyte differentiation through the activation of Beta-catenin and LKB1/AMPK signaling pathway 1499 2056 355 PMC7518784__F2 Inflammatory induction of the colorectal cancer (CRC) occurrence 673 3845 6774 3577 3579 3605 50616 PMC7520283__F4 Wnt/B‐catenin signalling pathway in OA‐FLS inflammation 1196 2932 2296 324 1499 6774 PMC7520695__F2 Canonical pathway and activation mechanism of inflammasomes and outcomes in cancer 4615 114548 79792 PMC7520711__F1 Major regulators and effectors of the phosphatidylinositol 3-kinase (PI3K) pathway in lymphocytes 613 940 113791 930 8821 5728 5266 2475 PMC7524833__F1 Interleukin-2-inducible T cell kinase plays a central role in the signal transduction of the T cell receptor 324 3932 3702 7409 5335 27040 3662 920 PMC7525032__F6 Scheme of the proposed lung IIR against S 4615 7099 7097 2919 3553 PMC7526126__F1 InterferonG signaling 3717 3716 6772 2475 3659 PMC7526126__F3 InterferonG mediated cancer regression 2019 836 841 840 842 23657 6520 3091 7422 PMC7530265__F9 The potential protective effects of PA in LPS-induced intestinal barrier dysfunction 7099 3553 114548 PMC7533558__F9 How CRLF1 promotes HLF formation 3553 3131 9244 4088 4313 PMC7537271__F3 SARS‐CoV‐2 activates innate immune pathways 7189 3665 3661 4615 51311 51284 29110 7187 7098 7099 3146 114548 PMC7540116__F1 Metformin inhibits cancer invasion and migration via AMPK signaling pathway 3479 3480 7248 64798 7249 595 PMC7540116__F2 Metformin inhibits cancer invasion and migration by blocking EMT signaling pathway 4087 4088 6774 4089 2475 9839 6935 PMC7541012__F2 Roles of cancer‐associated fibroblasts (CAFs) in cancer chemoresistance 4040 6774 3569 51135 3082 3976 3479 7474 1116 9945 3586 596 283120 PMC7541823__F7 Antigen presentation, T‐cell responses and activation of the cytosolic surveillance pathway (CSP) in the case of Mycobacterial infection of APCs 920 911 567 909 115004 3661 PMC7543045__F9 Schematic model showing G10 activation of the NLRP3 inflammasome in porcine cells 114548 29110 3661 834 3553 3606 PMC7545020__F2 An aberrant STAT pathway is central to COVID-19 7297 3716 6772 6773 10379 PMC7545699__F7 Schematic diagram illustrating the role of repression of FGF signaling in inducing Dnmt3b inhibition during early development of IVF embryos 2247 2249 6667 1789 PMC7546716__F1 T-cell polarisation in COVID-19IL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs 2625 50943 90865 6761 3558 7054 2833 3458 4283 3627 4615 114548 3603 6097 6774 6347 6355 729230 PMC7547786__F1 Th-17 cell polarization from naïve CD4+ T cells and activation 324 3717 149233 6774 6095 3605 PMC7551201__F6 S100A4 increased motility of tumor cells 6275 7099 1499 595 PMC7551806__F1 Putative molecular mechanisms involved in the development of sarcopenia during aging 3479 3480 4087 4088 2475 PMC7555602__F3 Impact of redox imbalance on canonical pathway of miRNAs biogenesis 29102 5901 2932 PMC7559526__F8 Melanin synthesis pathway related genes in dorsal and ventral skin of LBM ducks 5443 434 4286 PMC7560597__F1 Activation of the cGAS–STING signaling pathway to drive innate immune responses 115004 3661 7124 29110 PMC7560597__F3 Initiation of necroptosis by cGAS–STING signaling 3454 8737 11035 197259 7124 PMC7563527__F1 Versatile cross-talks of CAF with activated progenitor cells and HCC 7040 6347 6469 3082 619501 PMC7564554__F7 lncRNA–mRNA co–expression network 100505573 2113 100506801 100507616 112935892 PMC7564666__F6 Protein Expression of Let-7a Target Genes are Altered in a LASP1-Ago2 Interaction-Dependent Manner 27161 3927 1236 1982 595 6387 PMC7564904__F1 In vitro Bacillus Calmette-Guérin (BCG) training 64127 2475 3553 7124 PMC7565148__F7 Summary of WARS1 signaling pathway in macrophages 7453 2920 4615 6850 7099 7097 PMC7567162__F7 Tripterygium ingredients could inhibit multiple pathways, such as the NFKB pathway, JAK-STAT pathway, and PI3K-mTOR pathway, to regulate the hyperactive as well as pathogenicity biological functions in a various type of cells ( to ) 324 3558 3569 3553 PMC7569249__F5 Overexpression of Rab40b promotes hepatocellular carcinoma cell proliferation and metastasis by upregulating cyclin D1, cyclin E1 and MMP2 via PI3K/AKT signaling pathway 10966 595 898 4313 PMC7569567__F2 Kinase inhibition in autoimmunity and inflammation 3458 11009 29949 2056 7173 3976 85480 5008 3718 7297 3717 6778 6774 6775 6772 6773 PMC7569567__F8 Kinase inhibition in autoimmunity and inflammation 613 958 4050 5971 5970 7187 7186 PMC7573881__F5 Network of lncRNAs involved in regulating the Th cell activation pathway in tongue squamous cell carcinoma 925 3383 920 2885 8651 9021 6775 864 2625 6774 406991 406947 406938 407021 1234 2833 3458 PMC7576264__F9 Rab27A promotes ROS production and apoptosis via suppressing miR‐124‐3p and increasing STAT3/RelA pathway in inflammatory colonic cells 5873 6774 5970 PMC7578258__F2 Metabolic rewiring and redox adaptation induced by BRAFi during melanoma progression 673 4286 101927152 PMC7581685__F2 Part of the innate immune signaling pathways triggered after the viral RNA is recognized by TLRs and RLRs 3454 3455 7297 3716 7098 51311 51284 57506 6772 6773 4615 10010 7187 29110 3661 3665 PMC7582690__F2 PI3K/Akt signaling pathway converges to facilitate the progression OS 10457 558 1524 6714 3479 57291 7546 283120 2475 3383 127841 PMC7583966__F3 Interferons after ligating to type II receptors activate JAK/STAT pathway resulting in foam cells formation leading directly to atherosclerosis development 3717 3716 6772 19 29949 11009 PMC7584092__F10 Drug-compound-target-pathway network 5742 5743 240 836 2159 4048 2155 PMC7585948__F10 Targeting feed-forward signaling of TGFB/NOX4/DHFR/eNOS uncoupling/TGFB axis with anti-TGFB and folic acid attenuates formation of aortic aneurysms 7048 7046 1719 50507 PMC7586430__F1 Ubiquitination-proteasome of NEDD4 E3 ligases pathway 4734 23327 11059 83737 11060 PMC7589024__F10 Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐KB and TNF‐A/TNFR1/NF‐KB pathways 3146 7099 4615 7124 7186 3553 PMC7589120__F1 Pathway connecting lipid synthesis, lysosomes dysfunction and iron accumulation in NBIA syndromes 83636 80025 80347 80067 2512 11152 1356 8398 PMC7589702__F7a Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway 196 405 85451 860 PMC7589994__F1 Role of the best-characterized HDACs in liver fibrosis 7040 25805 7099 4087 4088 4092 3065 4089 3066 9759 23411 9734 2146 PMC7593769__F7 Model of the C. acnes-induced intracellular signaling pathways 4615 115004 29110 3661 PMC7593846__F7 Signaling pathway analysis based on the potential biomarkers (A) Summary of ingenuity pathway analysis with MetaboAnalyst 7421 5741 55364 PMC7598587__F7 Putative molecular pathway of catalpol in the skeletal muscle of type-2 diabetic mice in amelioration of glucose homeostasis and insulin sensitivity 23411 3667 1431 PMC7598934__F6 MDA-7/IL-24-mediated inhibition in progression of PC-induced bone metastasis through modulation of the bone microenvironment 4772 11009 2932 PMC7599984__F3 TGFB family signaling pathway 4087 4088 4090 4086 4089 PMC7600656__F5 Hepcidin expression via bone morphogenic protein (BMP)-SMAD signaling pathway in hepatocytes 7037 7036 164656 4090 4086 4089 3077 PMC7603193__F1 Interactions between non-coding RNAs and the TGFB signaling pathway in hereditary hemorrhagic telangiectasia (HHT) 7046 4090 4086 4087 4088 4089 54487 29102 339290 768097 PMC7607115__F2 Model for TERT promoter mutations, TERT expression and telomerase activation during the pathogenesis of TC 673 7253 7157 7015 1029 PMC7608146__F8 Wnt signaling and Loxl2 promote aggressive osteosarcoma 1956 7477 7483 79971 6935 9839 239 PMC7641541__F2 CR2 site-targeted complement inhibitors 1378 966 2271 1380 PMC7643807__F1a Activin Receptor-Ligand Trap for the Treatment of Beta-thalassemia: A Serendipitous Discovery 9573 2662 10220 2657 60 4087 4088 4089 PMC7643807__F1b Activin Receptor-Ligand Trap for the Treatment of Beta-thalassemia: A Serendipitous Discovery 100187907 9573 2662 10220 2657 60 4087 4088 PMC7645992__F10 Prosed schematic proposed mechanism underlying the impact of DDP4 inhibition on protecting the cell from apoptosis and oxidative stress through regulating the PI3K/AKT/m-TOR signaling pathway 2475 3553 3569 PMC7654410__F1 Neddylation inactivation by MLN4924 treatment or genetic deletion is involved in multiple regulatory responses within immune cells 7054 3569 729230 1234 942 PMC7655170__F9 Schematic mechanism underlying CUEDC1-suppressed NSCLC progression 404093 64750 4087 4088 PMC7655184__F1 Summary scheme of the cholesterol-mediated hepatocyte and stellate cell crosstalk pathway in NASH 3549 847 9113 PMC7658374__F1 TGF beta SMAD-dependent signaling pathway 659 92 7048 PMC7661081__F1 MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome 53637 1901 1903 8698 9294 PMC7662708__F5 Kynurenine Induces Osteoclastogenesis Via the AhR Signaling Pathway 196 4772 1545 PMC7663173__F5 YZT-mediated network analysis reveals UPS as potential target 7296 5962 10658 5978 9641 3162 3861 4738 7316 8737 7314 6869 9099 57646 54768 4139 4140 527 2011 3592 PMC7663488__F3 Impaired regulation of lipid metabolism by AMPK in renal cells in obesity/diabetes 948 3156 355 PMC7674197__F1 TLR signaling and the endogenous DAMP pathway in systemic JIA and AOSD 3146 6279 6280 3553 7099 4615 51135 3656 3654 114548 7189 51284 PMC7677104__F5 New, potential drugs targeting mainly immune cells, adapted and modified from Michalak 6850 2475 1043 695 3558 952 PMC7677640__F1 Mechanism of immune rejection caused by major histocompatibility complex (MHC) mismatch 324 920 7054 50943 3458 PMC7682230__F3 Hypoxia signaling pathway involves EGLN1-mediated hydroxylation and VHL-dependent ubiquitination of HIF-1A/2A subunits leading to its proteosomal degrardation under normoxic conditions 54583 3091 10320 7428 6667 PMC7683543__F5 Canonical pathway enrichment analysis identifies immune response classical complement pathway as the ones most enriched in PVEC co-cultured with NPC 1378 720 1499 PMC7684869__F2 Schematic figure of NPY and leptin in local homeostasis of bone remodeling 4280 4852 154 PMC7685705__F9 The role of TRAF3 in density-dependent proliferation 7186 7187 5971 PMC7687032__F3 Blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity 54210 54209 348 6850 2475 PMC7687355__F6 Temporal differences in activation of IL6 signaling after APAP300 and PHX 10563 1052 23516 29887 79689 7133 3569 1051 1026 6774 1956 1439 3484 3956 PMC7688515__F1 Immunometabolic pathway during mycobacterial infection 5465 7942 3553 PMC7693462__F4 Hypothesized role of NAA in cancer cells as an alternative source of acetyl-CoA for specific transcription factor acetylation in place of citrate 2056 55902 23411 443 339983 1431 47 PMC7693462__F5 NAA and citrate pathways to acetyl-CoA 443 339983 55902 47 PMC7695834__F8 Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway 657 4090 4086 PMC7696189__F7 Tyrosine kinase inhibitor (TKI)-based OFF-switch 930 920 3932 7535 PMC7697665__F2 Role of RNF11 in the transforming growth factor beta (TGFB) signaling pathway 64750 57154 23327 11059 4092 4087 4088 4089 26994 83737 PMC7697917__F8 BDNF pathway 627 4915 3066 6722 2353 6774 5970 196 PMC7699852__F1 Simplified representation of aryl hydrocarbon receptor (AhR) pathways 5053 196 1543 405 1499 PMC7699880__F2 Leptin–melanocortin pathway 23237 6492 3953 4160 PMC7701511__F3 VEGFA/VEGFR2 system differentially modulates the UPR activation in condition of transient or sustained ER stress 22926 83939 7422 PMC7705115__F3 Crosstalk between the PI3K/Akt and JAK2-STAT5 signaling pathways 8544 3480 3717 PMC7707960__F1 Regulation and interaction of Rac1-related signaling pathways at the postsynaptic terminal 627 85358 4204 26053 6792 63916 5879 140805 PMC7708424__F5 An example of where Pascal pathway enrichment and HotNet2 home in on the same pathway causal of Hyperlipidaemia 337 344 345 6272 4547 7436 348 29116 3949 9619 341 949 335 338 255738 3990 6927 3931 4023 19 336 PMC7709261__F2 Function of lncRNAs in regulating TGFB signaling pathway to affect HCC tumorigenesis 283131 55384 378938 7046 647979 3880 7048 283120 92249 PMC7716145__F3 LPS-producing bacteria interact with TLRs through the NFKB signaling pathway 4615 7186 9618 3606 3569 7124 PMC7716161__F3 Role of IL-17 in the pathogenesis of acinar duct metaplasia, pancreatic intraepithelial neoplasia, and pancreatic cancer 3845 9201 133 PMC7723674__F8 Mechanism of action of nimbolide in diethylnitrosamine and N-nitrosomorpholine induced hepatocellular carcinoma mice 1019 3553 595 5111 619501 PMC7726811__F1 PIDDosome pathway regulates HCC initiation and expansion 619501 1869 835 55367 PMC7727191__F3 Signaling pathways which CD44 regulates 960 4313 4318 6714 4193 4088 1499 PMC7729630__F5 Schematic model illustrating an effect of PEA on CORT-induced depression-like mice model 134864 1325 627 6855 PMC7730964__F1a Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness 4040 4041 1499 324 2932 90780 607 PMC7736543__F2 Reciprocal signaling between the capsule and cortex coordinately regulates SHH and Wnt pathway activation 6469 5727 54361 6608 1499 84133 84870 PMC7738817__F5 miR-133a involves in EGFR/c-Myc/P53 axis and the associated signaling pathway 6387 7852 7503 1956 387 PMC7744479__F2 Lymphoma induced angiogenesis in LNs and participating immune cells 4050 4049 7422 2247 3603 4318 7424 1878 8178 6363 1236 2833 960 4283 6366 PMC7745315__F6 Expression of the NEK7/NLRP3 inflammasome pathway in patients with diabetic lower extremity arterial disease 140609 114548 3603 PMC7747191__F2 Toll-like receptor signalling in B cells during systemic lupus erythematosus 51284 613 3902 643 3458 PMC7750395__F9 Graphic abstract of IAV-induced acute lung injury 3146 7099 4353 PMC7755484__F7 Proposed mechanism of AS-IV-induced melanogenesis 196 7306 1499 4286 PMC7758070__F8 Proposed model of GGGGCC repeat expansion pathogenesis 7942 4286 203228 PMC7759999__F1 Opsonized epithelial apoptotic particles and ICs containing nuclear autoantigens bind to plasmacytoid DCs (pDCs) and RF B cells via TLRs and Fc receptors, respectively 613 5132 2638 PMC7761032__F2 Potentials and Pitfalls of a Human Cervical Organoid Model Including Langerhans Cells 7186 3716 6774 3718 3717 7297 6775 PMC7764362__F2 Negative regulation of interferons (IFNs) by autophagy 7099 3454 3455 7297 64127 79671 6773 6772 57506 54106 10379 7098 51311 51284 4615 7187 51135 3656 29110 3665 3661 PMC7765227__F3 Signal transducer and activator of transcription (STAT)1 and STAT3 pathways in the inflammatory response 6772 6774 6352 3665 7318 5292 8651 PMC7769624__F10 Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling 4615 7099 7189 PMC7778818__F5 The HO in the present case 650 2736 4087 4088 860 PMC7783467__F3 FGF19 and FGF21 treatment of NASH 26291 9965 2264 152831 7038 1581 7045 PMC7792207__F3 Pathway involving the non-canonical NF-kB activation through NF-kB-inducing kinase (NIK/MAP3K14), modulated by cIAPs 958 7186 7187 5971 PMC7792222__F2 miRNA-mediated regulation of BCSCs via targeting the Wnt/Beta-catenin signaling pathway 693185 22943 8312 324 1499 6925 595 4041 4040 PMC7793832__F2 NLRP3 inflammasome activation following non-canonical inflammasome activation 114548 3553 79792 PMC7797639__F7 [missing figure legend] 1950 1956 339123 PMC7802449__F4 Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease 7253 11319 3480 PMC7803748__F2 Muscle atrophy and hypertrophy: implications in health and disease 655 10220 4091 4092 4090 4086 4087 4088 2475 4089 PMC7803748__F4 Muscle atrophy and hypertrophy: implications in health and disease 3667 7186 8717 7189 PMC7805053__F4 Schematic diagram depicting IL17RD (Sef) modulation of the TIR signaling pathway 4118 4615 7189 3661 54756 7099 PMC7806375__F7 Working model of this study 10000 2932 1499 PMC7810547__F2 miR-155 modulates TLR4 signaling pathway in sepsis 7099 4615 7189 3654 8651 406947 PMC7813969__F1 Sex bias of females in survival from cancer and infections. Is X the answer? 3458 2146 7403 PMC7815887__F2 T2 inflammatory pathway (eosinophilic COPD and asthma) and the target sites for anti-IL-5 agents 64806 85480 90865 2625 3568 PMC7818184__F4 VPS4B affects tooth development‐related gene expression through Wnt/B‐catenin pathway 128866 9525 7474 2932 324 1499 PMC7819896__F1 Cartoon representing the overview of the pathogenesis of COVID-19 and the potential activity of ruxolitinib 3718 3716 3717 PMC7824196__F2 Autophagy regulation by the mTOR signaling pathway 2475 8408 54822 23411 PMC7825621__F2 miRNA targeted network of cancer signaling including senescence 3562 3683 23135 57142 1053 10658 1030 894 896 5928 5931 4087 23512 5111 1869 8726 2146 121536 PMC7826796__F1 Metabolic pathway of vitamin D (based on Feldman et al., 2014 , Jekinson 2019 and Dou et al., 2016 with own modifications) 1717 4827 120227 1593 1591 1594 7421 PMC7829997__F2 Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Signals in Host–Microbe Interplay 3620 6964 196 PMC7830067__F1 Metformin enhances CD8+/CD4+ ratio to favor an immunoreactive microenvironment 2475 50943 3458 7124 920 PMC7835019__F9 Proposed model depicting the involvement of the eNOS/cGMP/PKG pathway in PF activation 55294 2475 3815 PMC7835870__F1 Metabolic conversion pathway from the essential omega-3 PUFA, ALA, to longer-chain omega-3 PUFAs, EPA, DPA and DHA 9415 60481 3992 54898 PMC7846556__F1 Inhibition of gasdermin D-mediated pyroptosis by necrosulfonamide, disulfiram, and dimethyl fumarate 834 79792 3553 PMC7847067__F1 Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism 4851 2842 5166 PMC7848762__F4 This network represents the interactions among the top-ranked genes participating in fusions in (A)T-cell acute lymphoblastic leukemia and (B) B-cell acute lymphoblastic leukemia 22944 4005 4297 6886 896 4004 9833 6964 PMC7849620__F4 Mechanisms of abnormal coagulation and hepatic ischemia/hypoxia reperfusion injury in COVID-19-associated liver injury 7450 6347 729230 51284 7099 3553 3576 3627 PMC7851184__F2 Proposed mechanisms of neoplastic transformation of small intestinal ILCs in refractory CD II 5111 3600 50943 920 4851 PMC7853124__F1 Immunopathobiology and therapeutic targets related to cytokines in liver diseases 4283 920 6772 2919 619501 3595 3594 6775 3559 3560 PMC7854724__F6 TGFB signalling acts as a molecular brake of myoblast fusion 7048 7046 4089 4087 4088 PMC7862680__F7 Novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway 6935 283659 7408 PMC7862811__F1 PI3K/AKT signaling pathway activation and potential functions of LAPTM4B in cancers 55353 595 1385 PMC7864206__F1 Essential molecules of the mammalian Hedgehog signaling pathway and their interactions 84976 57758 51684 2736 2737 5727 6608 2735 55733 PMC7864484__F2 Nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family apoptosis inhibitory protein (NAIP)-NLR family caspase recruitment domain-containing protein 4 (NLRC4) inflammasome-mediated PANoptosis, inflammatory cell death 58484 3394 841 834 79792 840 836 197259 PMC7864581__F7 Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling 8239 4851 57534 860 2597 PMC7865493__F2 Molecular interactions within the AhR signaling pathway 6778 196 405 5017 1543 2312 3162 1728 PMC7865797__F1 Carbon-source preferences and use in cancer metabolism 2539 26227 3939 5091 6319 PMC7865845__F2 Role of the discussed NLRs in type I interferon signaling 7099 64127 8767 115004 57506 79671 1665 171389 7189 1660 54106 51284 7098 10392 204801 4615 91662 197358 7187 84166 51135 3654 29110 338323 147945 55655 58484 3661 3394 3665 3663 PMC7868402__F3 Regulatory effect of methylation levels of bone metabolism-related genes on bone formation (; ; ; ; ; ; ; ; ) 650 860 50964 PMC7870930__F3 Progress in understanding the role of lncRNA in programmed cell death 7124 8737 197259 11035 PMC7876374__F2 Effect of EGCG on miRNA and Ca2+signaling in T cells 920 5728 2475 57620 84876 8178 PMC7879452__F6 In nucleus, Lnc-BTG3-7:1 co-regulates the transcription of C21ORF91 gene with nuclear synergistic transcription factor JUND 1499 2885 2932 3727 54149 PMC7880663__F3 Role of astrocytes in post-traumatic synapse loss and repair 2047 6774 4314 PMC7881399__F3 Sub-network including 12 hub-bottleneck nodes and two seeds of clusters 1 and 2 1956 3565 5743 3630 213 3569 479 2641 3576 9370 4586 7422 7124 PMC7882715__F3 Possible mechanism of polymorphism influences related with MAPK and PI3K/AKT cell signaling 1557 1565 7364 10090 PMC7891830__F2 Golgi resident proteins and membrane trafficking pathway 27032 2245 10564 57530 6399 PMC7892952__F1 Adenine-based purines are ubiquitous compounds present at intra- and intracellular levels in normal (i.e., astrocytes) and tumoral (i.e., GSCs) cells 84890 100188857 4922 PMC7894021__F6 Epidermal growth factor (EGF)‐mediated high‐mobility group protein A2 (HMGA2) transcription in hepatocellular carcinoma (HCC) cells 1950 1956 8091 PMC7895513__F7 Regulatory effects of PCSK9 on endothelial cell pyroptosis by increasing ROS production via the inhibition of UQCRC1 7384 255738 114548 3553 79792 PMC7897244__F1 TGFB signaling pathway 659 92 93 269 7048 PMC7897244__F6 Proposed pathological roles of ligand competition 4090 4086 4087 4088 5053 PMC7903415__F1 The signaling pathways in LF by lncRNAs 114004396 100316868 283120 5820 55384 84973 1499 PMC7904598__F2 Bi-directional EV-mediated communication between astrocytes and glioblastoma cells 3603 2670 6774 PMC7904891__F1 Susceptibility and protective factors of the lectin pathway of complement and complement receptors, for HBV infection per se and HBV infection/leprosy 5648 720 721 718 8547 1378 PMC7905103__F5 Diagram depicting a potential mechanism of interactions 3929 671 7099 929 PMC7906184__F10 Graphic depiction of the conclusion from the present study 7503 6667 120892 PMC7906938__F2 Immunological Mechanisms Underlying Sterile Inflammation in the Pathogenesis of Atherosclerosis: Potential Sites for Intervention 3845 7097 7099 114548 10333 3146 6283 3654 4615 948 3553 PMC7907466__F1 Complement Cascade in HIE 717 729 730 735 PMC7908992__F3 Main molecular mechanisms involved in the antioxidant activity and the beneficial effects of dietary polyphenols in metabolic, cardiovascular, and neurodegenerative diseases 8408 8678 7942 PMC7911620__F1 TLR-activating adjuvants and the induced signalling pathway 4352 7096 7097 7100 7099 4615 7098 54106 51284 51311 3553 6347 942 941 PMC7912811__F2 Signal transduction of the putative truncated GnRH-II receptor in endometrial cancer (EC) 1950 1956 619537 3727 PMC7913190__F2 Caspase-11 upregulation occurs as a result of PAMP and/or cytokine signaling and can be amplified by complement signaling 718 3458 3455 1360 3717 7297 4615 4118 3716 3654 51135 7189 6773 6772 29110 10379 3661 3665 7124 114548 PMC7913382__F5 Mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) pathway crosstalk, downstream effects, and inhibitors currently being trialled in pancreatic cancer treatment 1950 1956 2885 6774 3845 PMC7914341__F8 PRLR-SF inhibits pentose phosphate pathway through NEK9-YAP/TEAD1-G6PD/TKT axis in PDAC cells 91754 7003 7086 2539 PMC7917964__F10 Ingenuity Pathway Analysis 85480 5054 90865 7099 4780 196 6097 7157 6774 3725 1050 1051 3172 7421 5468 PMC7918973__F1 Nrf2/ARE signaling pathway 9817 1728 2730 2729 4094 PMC7920062__F1 Bile acid metabolism 1581 1593 10858 4280 PMC7924357__F1 Angiogenesis pathways in malignancy and targeted therapies commonly used 1950 5155 1956 2475 PMC7925099__F1 HIV-1 life cycle, assembly pathway, and assembly plate screen 1234 920 643 1656 PMC7926735__F1 Transforming growth factor B (TGFB) signaling regulation by actin remodeling induced by extracellular matrix (ECM) stiffness 23592 4087 4088 57591 4089 PMC7929780__F7 Canonical Notch signaling with points of intervention of current therapies 102 6868 100188776 50863 PMC7930375__F1 Vitamin D (both D3 and D2) metabolic pathway and its physiological impact on immune cells 5212 120227 1594 7421 920 PMC7931689__F2 Identification of a functional network and laryngeal cancer-associated DEGs from the red-green overlapping DEGs 4015 8139 22795 6678 10631 633 1462 7058 3912 5159 2335 1301 1300 1278 80177 PMC7932307__F2 Nucleic acid immunotherapeutics that can activate the cGAS-STING signaling pathway 115004 3661 6778 PMC7933428__F7 Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics 9817 1878 8178 PMC7933988__F7 Action of mesenchymal stem cells in the vestibular microenvironment 7124 3603 9242 3717 6774 4609 9111 PMC7935450__F1 CGAS-STING signaling pathway 115004 3661 29110 PMC7936186__F6 Schematic representation summarizing the integrated effects of PFA-enriched diets on intermediary metabolism in the broilers 5198 22937 3990 2475 6198 PMC7937674__F8 Schematic overview for the positive feedback loop between OTUD5 and mTOR signaling pathway 55593 100420631 64798 2475 PMC7937872__F7 Proposed resisting the excitability toxicity signaling pathways triggered by ICT in ischemic neurons 1956 2852 1950 6714 PMC7940541__F7 Schematic model: the mechanisms through which huaier extract inhibits the growth of prostate cancer 367 9097 7113 354 64754 PMC7941238__F2 Mechanisms by which ADSCs‐EXOs may promote wound healing 5950 1000 5111 4314 PMC7948473__F7 Proposed function and mechanism of ppGalNAc-T4 in breast cancer progression 4087 4088 4089 6615 PMC7950231__F5 Induction of type I interferons and signalling leading to the innate immune response during SARS-CoV-2 infection and drug pair action site 3454 51284 285852 3455 4615 3716 7297 7187 7189 7084 6772 6773 29110 6885 9641 10379 8517 1147 3551 3661 4792 4938 4939 4790 4940 PMC7950238__F5 Signaling pathway diagram 10628 114548 79792 2626 PMC7952454__F3 DNASE2A deficiency causes an accumulation of phagocytosed dsDNA as well as nuclear dsDNA transported by autophagy into endolysosomal compartments 9447 23646 122618 54106 51284 3553 115004 4615 3661 3458 PMC7952751__F3 Schematic representation showing the interaction between foot-and-mouth disease virus (FMDV) viral proteins and host proteins in the innate immune system 7297 51284 57506 7095 6773 10010 7187 10379 29110 6774 3661 3665 2098 4938 4599 PMC7957049__F2 Wnt signaling pathway activation and inhibition 2932 1499 324 PMC7962349__F6 Intervention of natural products from traditional Chinese medicine on the TME 7099 3661 6774 PMC7968419__F1 Schematic presentation of possible cross-linkages between PCOS and HT 3973 2492 2798 50943 1493 26191 268 84467 1586 7200 1545 2304 140805 PMC7969890__F1 Elements of the classical and alternative complement pathways, separated by the unique and common aspects 4965 718 721 717 PMC7971856__F7 Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol 7099 57506 115004 81858 PMC7972864__F1 Proposed model of signaling pathway involved in FUC prevented 6-OHDA-induced ROS 9817 2730 2729 4094 PMC7973041__F6 m6A methylation plays a critical role in adaptive immunity 920 3716 54915 51441 253943 56339 7428 29851 PMC7974260__F2 Representative diagram of circRNAs that interact with the circRNA-miRNA-mRNA regulatory network/RBPs and regulate oncogene or tumor suppressor signaling pathways 24137 6546 7916 4638 5728 7424 7422 4089 3939 2339 23060 PMC7980828__F4 Flavivirus; entry, life cycle, and immune system interaction: (A) Flavivirus infections are generally transmitted through the bite of an infected mosquito or tick 5045 3665 3661 3440 6772 8651 PMC7982659__F3 Ingenuity Pathway Analysis (IPA) 5607 374 8805 2069 940 1050 1839 1435 5604 7040 1440 22937 1053 PMC7982729__F4 Autophagy-mediated elimination of pathogens 7097 7099 29110 7189 115004 7098 51311 51284 3661 3665 PMC7984366__F3 Estrogen-like molecules activate the classical estrogen signaling cascade and alternative pathways 2852 23411 2932 1499 PMC7990367__F3 Pathways regulating cellular senescence and the SASP 472 545 2475 115004 6772 6774 2626 10758 3552 23411 PMC7990793__F4 Potential working model of IL-35 immunepathogenesis in chronic HBV infection 10148 7297 3716 6775 3595 PMC7993417__F4 Phenotypic diversity and metabolic specialization of renal endothelial cells 27040 847 355 23410 PMC7994620__F4 Activation of cyclic AMP pathway through various genetic defects in adrenocortical tumors and hyperplasias 8622 50940 2778 5573 5575 5566 5567 PMC7997388__F1 The human complement system 718 721 717 2271 727 1380 729 730 735 27202 966 1356 PMC7998619__F2 Viral immune evasion in the placenta utilized by cytomegalovirus (CMV) and Zika virus 100187761 51284 7098 54106 4615 10379 57506 3661 3665 7124 3569 3576 6347 942 941 PMC7999260__F3 Combination therapy for miR-21i and TMZ 406991 5728 6774 596 PMC7999830__F7 The proposed model 4780 3162 3553 PMC8000576__F1 BCL-2-regulated apoptotic pathway 572 637 638 8739 90427 581 PMC8001237__F1 An overview of various approaches used in myostatin inhibition 2660 4087 4088 PMC8003318__F2 miR-29a and HCC carcinogenesis 317 4170 4193 5155 5728 6605 PMC8003318__F5 ceRNA acts as miR-29a sponge to positively promote HCC progression 407021 4170 83606 90632 728655 55000 100133311 6091 PMC8004672__F7 Correlation between growth factor signaling, the actin cytoskeleton, and CCN2 expression in CHs 3479 7039 1490 5879 PMC8005042__F7 Pyrimidine biosynthesis in the pyrimidine metabolism pathway 1723 7372 790 PMC8005659__F1 Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3B/Beta-catenin signalling pathway 4040 4041 79792 2932 23410 114548 1499 8313 3553 860 PMC8008798__F1 General scheme illustrating the potential mechanistic pathway of Notch signaling in the pathogenesis of pulmonary fibrosis 182 55534 84441 9794 3516 PMC8012432__F1 Novel Method to Differentiate Tonsil-Derived Mesenchymal Stem Cells In Vitro into Estrogen-Secreting Cells 1583 1586 1588 412 PMC8014260__F1 Toll‐like receptors in the pathogenesis of COVID‐19 7189 3661 7187 3665 7187 7189 3661 51135 3665 PMC8017223__F1 IL-23 receptor polymorphism associated disorders 7297 3717 6774 6775 PMC8029610__F1 CGAS–STING pathway as a therapeutic target in inflammatory diseases 115004 29110 3661 6836 3456 PMC8032975__F2 Lipoproteins and their three different metabolic pathways 348 4023 471 344 4547 3931 1071 5360 PMC8033157__F1 Induction of type I IFNs in response to viral infections 7099 4615 7189 7187 7098 29110 6041 6035 3654 115004 54106 51311 3661 3665 57506 64423 51135 3656 PMC8039952__F4 Approaches to turn a “cold tumor” into a “hot tumor” 1638 942 940 941 7852 PMC8040227__F2 Canonical and non-canonical activation of NLRP3 3603 8717 3654 51135 7186 7189 114548 PMC8042267__F4 Therapeutic approaches targeting IL23 and IL17 signaling 3605 149233 3594 3595 PMC8042664__F5 Schematic model 3553 3606 4312 PMC8042693__F11 PPI network 125 126 2938 54577 PMC8044762__F2 cGas-STING activation pathway 5167 79065 3661 PMC8044947__F1 Popular signaling pathway in the research of primary mediastinal large B-cell lymphoma 567 6778 8651 3566 3717 5770 PMC8045357__F1 SOCS protein structure 8651 9021 8835 122809 30837 4118 7189 3661 3665 PMC8052259__F2 m6A regulates IFNB and the type I IFN response 3661 51441 7297 6772 3716 6773 3454 3455 10379 54915 PMC8052259__F3 m6A regulates immune cell function 7099 114609 54915 941 958 4615 940 1154 3718 8651 PMC8053758__F4 Promising targets for therapy of osteoarthritis: a review on the Wnt and TGFB signalling pathways 1196 23411 2308 PMC8055291__F5 Illustration of TNF signaling pathway influenced by major putative targets of GBKC 7185 7186 7187 6347 3553 3569 5743 4318 PMC8062415__F7 Hub genes associated with Interleukin-3-mediated signaling pathway 3481 2274 331 7057 3479 5782 60676 7448 3483 4067 3280 PMC8063120__F4 Long non-coding RNA (lncRNAs) and microRNAs (miRNAs) involved in osteogenic pathways in Bone Marrow Mesenchymal Stem Cells (BMSCs) 4091 4087 4088 4086 64750 57154 8195 324 1499 860 PMC8065725__F6 Wnt/Beta-catenin signaling pathway in chronic HCV infection and HCV clearance without (A) or with (B) metformin treatment 1499 595 4609 PMC8066826__F2 Adiponectin and its receptors and schematic representation of adiponectin-induced signaling pathway 51094 79602 26060 2475 PMC8070103__F4 RAF1 negatively regulates the proapoptotic Hippo pathway by binding to MST2 upon growth factor stimulation 355 4893 5894 9113 PMC8070923__F2 Main mechanisms by which active skeletal muscle can impact the brain 252995 23411 627 PMC8071039__F2 Signaling pathway and cell survival 572 596 3714 55364 PMC8071157__F4 MicroRNAs involved in aromatase regulation in breast cancer 406947 407006 407007 1499 406915 7046 PMC8071330__F3 Ovarian cancer stem cell (OCSC)-associated signaling pathways 4854 3717 6774 4040 4041 1499 6608 2735 5728 5727 PMC8072220__F8 Complex of distal appendage–associated kinases linked to human disease regulates ciliary trafficking and stability 146057 1457 22897 6608 51177 PMC8072960__F1 Androgens and Androgen Receptor in Human Bladder Cancer 367 6462 6716 PMC8073160__F1 Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review 9242 50964 5741 7124 PMC8073160__F4 Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review 2247 650 50964 8074 860 PMC8073244__F3 Viral Infection Modulates Mitochondrial Function 442917 57506 3661 3665 PMC8074054__F1 Sarcopenia and Vitamin D Deficiency in Patients with Crohn’s Disease: Pathological Conditions That Should Be Linked Together 7124 3603 3479 PMC8074257__F1 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers 3717 9021 25970 6774 2475 5728 2308 PMC8075731__F7 HGF/c-Met signaling regulates early differentiation of placental trophoblast cells 1356 3082 8466 PMC8076548__F8 Baricitinib Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway 3716 3717 6774 6772 6775 PMC8080978__F9 Hypothesized mechanism of action of downregulated ERBB4 in SARS-CoV-2 infected cells 2066 1956 324 7113 PMC8081922__F5 Beta-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts 2695 2696 1499 4015 PMC8088080__F6 Unraveling the molecular crosstalk between Atherosclerosis and COVID-19 comorbidity 7099 2921 3576 2920 7097 4615 51199 7189 PMC8088471__F7 Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling 494327 51684 2735 PMC8091149__F6 Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell function 1861 27189 55829 6288 51295 23765 5270 9510 949 3552 112744 1291 7124 5327 7078 6774 83729 5970 5898 3725 8737 6416 PMC8093290__F6 Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway 7408 7099 114548 3553 PMC8093449__F2 In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention 1103 43 3781 PMC8094964__F10 DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication 1649 220213 57154 57506 4599 PMC8096907__F2 miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases 4087 4088 4089 4092 79753 3662 8651 494333 9021 10401 6774 50615 149233 100302142 100302167 PMC8097353__F1 Deubiquitinating enzyme USP42 stabilizes RNF43/ZNRF3 at the plasma membrane 84133 54894 55366 8549 59352 84132 PMC8101316__F1 Proposed Parkinson Disease Genetic Testing Pathway 65018 5071 6622 120892 PMC8103163__F7 Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1B/CXCL1 Signaling 3553 7099 114548 79792 PMC8105286__F1 Biophysics of Notch Signaling 1950 717 102 4827 3516 PMC8106640__F6 PLPPR1 modulates RhoA-ROCK pathway 54886 387 4018 PMC8108341__F9 Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9 8914 1499 595 51176 PMC8111166__F2 Kynurenine pathway 8942 125061 8564 PMC8113373__F2 CircRNAs: role in human diseases and potential use as biomarkers 1856 83737 324 1499 595 4609 2932 PMC8115506__F1 Excess levels of cytoplasmic TDP-43 lead to mitochondrial penetration of TDP-43 which may trigger mtDNA release with ensuing activation of the cGAS/STING immune sensor 3661 7124 115004 29110 2147 PMC8121456__F1 CGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease 9447 3553 29110 3661 115004 54106 4615 3665 PMC8121456__F2 CGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease 115004 29110 3661 6772 6773 10379 PMC8121554__F6 Isoquercitrin protects HUVECs against high glucose-induced apoptosis through regulating p53 proteasomal degradation 581 596 9100 PMC8122612__F4 Salivary Proteome Changes in Response to Acute Psychological Stress Due to an Oral Exam Simulation in University Students: Effect of an Olfactory Stimulus 2171 213 80740 396 2165 4153 3514 280 3512 3042 256933 55200 3494 126069 4589 140683 56287 PMC8122623__F2 Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia 6424 50964 4040 4041 4920 9794 100188776 9242 PMC8122623__F3 Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia 1267 2885 6497 9242 PMC8124433__F10 Meta-Analysis of Methamphetamine Modulation on Amyloid Precursor Protein through HMGB1 in Alzheimer’s Disease 4314 3146 3554 177 355 4137 351 150 23621 PMC8125157__F2 Cholinergic Modulation of Neuroinflammation: Focus on A7 Nicotinic Receptor 3717 6774 9021 PMC8126045__F1 Lytic Viral Replication and Co-Infections in the Oncogenesis and Immune Control of the Epstein–Barr Virus 84061 5335 3702 10125 962 970 939 PMC8129546__F8 Gegen Qinlian Decoction Ameliorates Hyperuricemia-Induced Renal Tubular Injury via Blocking the Inflammatory Signaling Pathway 581 114548 79792 PMC8132044__F1 What does elevated TARC/CCL17 expression tell us about eosinophilic disorders? 5894 3459 3460 6772 8660 8651 6778 3662 6361 PMC8137523__F4 Tumor suppressors act as a checkpoint for mevalonate pathway flux by suppressing SREBP activity 5728 7428 11127 5371 19 3638 22937 PMC8137893__F1 Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma 4893 673 595 1021 1019 PMC8138266__F5 Inhibition of the Wnt/Beta-catenin signaling pathway reduces autophagy levels in complement treated podocytes 4040 4041 2932 847 PMC8139204__F2 CD36 Signaling in Diabetic Cardiomyopathy 948 6844 9341 8674 23216 3667 PMC8139965__F7 Hypothetical schema of the effect of IL-26 on EGFR-TKI resistance 1950 1956 467 468 2920 1649 2042 PMC8146627__F1 Interrelationship between pregnancy, venous thromboembolism, and thyroid disease: a hypothesis-generating review 5340 7035 7018 PMC8146983__SF1 Toward an Understanding of the Structural and Mechanistic Aspects of Protein-Protein Interactions in 2-Oxoacid Dehydrogenase Complexes 10157 132949 51166 2639 PMC8149889__F2 Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy 3135 6846 414062 3806 3805 10859 5087 4969 5764 PMC8155534__F6 Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling 4088 4087 3590 PMC8159873__F3 Cellular pathways involved in trained immunity 3480 948 2475 114548 958 7189 324 PMC8164580__F2 Neuronal dysfunction in HIV-associated neurocognitive disorders 4193 6714 3553 PMC8164981__F1 Bhlhe40 as a TRM metabolic regulator 8553 864 4851 4853 3399 7048 PMC8165101__F6 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives 637 638 581 PMC8166678__F7 “Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells 1021 1019 595 2305 1839 1956 PMC8174842__F5 Dickkopf-1: A Promising Target for Cancer Immunotherapy 22943 10970 3596 PMC8178581__F1 Notch signaling pathway involvement in innate lymphoid cell biology 4851 2322 3398 6932 7704 PMC8187247__F1 Antiviral strategies targeting herpesviruses 5819 5154 107966124 PMC8194041__F2 Stem cells in the treatment of renal fibrosis: a review of preclinical and clinical studies of renal fibrosis pathogenesis 4092 4089 4087 4088 9839 6935 PMC8197763__F8 Action mechanism of H2A.Z in HCC 5218 6929 604 3479 1026 6692 3728 PMC8204251__F1 Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy? 3454 3570 197259 2475 PMC8205579__F7 Baicalin Magnesium Salt Attenuates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting of TLR4/NFKB Signaling Pathway 4615 7099 3654 7189 7124 3603 PMC8205700__F4 Mesenchymal stem cell-derived exosomes: a promising vector in treatment for diabetes and its microvascular complications 4087 9839 2475 7099 7422 PMC8206147__F8 Schematic diagram of METTL14-mediated lncRNA OIP5-AS1 implicated in the Progression of PTC 729082 57721 11095 1956 PMC8206194__F2 Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints 4040 4041 1499 PMC8207720__F3 Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma 101234261 643837 84740 4313 2146 643911 23642 3191 324 100505746 283460 100128191 1499 7852 283596 6935 23411 652995 100316868 55031 8788 285987 55000 PMC8210162__F11 Novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells 10155 10772 4194 4193 PMC8212062__F7 Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway 652 79923 947 PMC8215263__F1 Effect of Oxidative Stress on Diaphragm Dysfunction and Exercise Intervention in Chronic Obstructive Pulmonary Disease 7124 7351 260431 PMC8216017__F2 CXCL12 in Kidney Diseases: A Friend or Foe? 7006 100124696 572 1803 7852 6387 PMC8220219__F1 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer 9113 26524 283422 100129597 8847 PMC8224095__F1 Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway 9817 2932 2534 PMC8224368__F2 Combined Single Nucleotide Variants of ORAI1 and BLK in a Child with Refractory Kawasaki Disease 2212 958 836 640 6850 80271 PMC8226237__F3 Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes 55128 4841 2547 860 3308 10048 PMC8226806__F2 Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension 6387 7852 9242 6469 659 9314 2263 2539 PMC8228851__F1 Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases 2475 3590 9021 PMC8229713__F7 Two-way rectification method for identifying differentially expressed genes by maximizing the co-function relationship 3458 836 4615 7097 841 114548 915 10392 3553 7124 PMC8229878__F3 Human Granulosa Cells—Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis 9973 407037 1583 860 1588 619552 406937 3479 3667 PMC8229934__F5 Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts 6772 4283 3627 6373 2833 PMC8233150__F8 A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1 4615 7189 29110 3661 PMC8235796__F1 Expression of Wnt and TGF-Beta Pathway Components during Whole-Body Regeneration from Cell Aggregates in Demosponge Halisarca dujardinii 324 2932 7046 9365 1499 4040 4041 PMC8236623__F1 Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance 8213 1950 1956 2475 PMC8237188__F1 JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib 3717 3716 7297 3718 3458 2056 PMC8237754__F1 Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review 23411 2597 2308 23476 PMC8238937__F1 MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis 7096 7097 10333 4615 7100 3654 51135 54106 7124 3569 3576 6347 942 941 7099 51284 7098 6772 PMC8242249__F6 Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFNB Production by Inducing Ubiquitination of RIG-I 54941 7706 29110 57506 7187 3661 PMC8245133__F6 The putative TAC-induced pathway that culminates in left ventricular hypertrophy 54795 4397 51393 9780 9759 4205 2626 PMC8247606__F2 Biological underpinnings of therapeutic resistance in pancreatic cancer 4199 9817 3845 PMC8249877__F2 Novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development 7424 5894 54345 5629 26524 9113 PMC8253380__F2 Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies 6608 51684 2735 64840 1499 4040 4041 PMC8256831__F2 Adult Hippocampal Neurogenesis and Alzheimer's Disease: Novel Application of Mesenchymal Stem Cells and their Role in Hippocampal Neurogenesis 9242 627 3479 PMC8259786__F4 NOTCH Signaling in Aortic Valve Development and Calcific Aortic Valve Disease 650 6662 4256 PMC8261186__F3 Vitamin D Toxicity Managed with Peritoneal Dialysis 120227 1591 1594 5741 8074 PMC8263651__F8 Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3B/Beta-catenin signaling pathway 324 2932 1499 4040 4041 595 PMC8263688__F8 IL-17 signaling pathway plays a key role in laryngeal squamous cell carcinoma with ethnic specificity 2921 4792 6354 4790 4322 3458 1437 51433 6885 3576 1051 2932 112744 1994 7128 841 4318 4314 5603 5595 8717 3606 6356 4312 84818 1147 7184 3727 7124 5599 7187 7189 5598 257397 132014 PMC8268320__F3 TGFB Pathway: A Pharmacological Target in Hepatocellular Carcinoma? 3600 1493 100187907 7939 PMC8269153__F2 NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus 23411 9817 355 PMC8275408__F1 Mitochondria in Liver Ischemia-Reperfusion Injury: From Aspects of Mitochondrial Oxidative Stress, Mitochondrial Fission, Mitochondrial Membrane Permeable Transport Pore Formation, Mitophagy, and Mitochondria-Related Protective Measures 3146 7124 4615 PMC8276676__F4 Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma 84818 717 7189 7124 PMC8277948__F10 Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630 693215 1316 2191 PMC8284339__F4 Integrative Analysis of Human Macrophage Inflammatory Response Related to Mycobacterium tuberculosis Virulence 6366 2920 2921 3604 8784 8764 6355 3586 3601 5473 8743 6373 10803 4283 10673 643 6361 3627 11009 PMC8285903__F8 GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion 5879 2621 558 PMC8286120__F4 Goblet Cells in Intestinal Barrier and Mucosal Immunity 4583 325 64806 90865 PMC8293073__F5 BMP Signaling in Osteoclast Regulation 4090 4086 4089 331 23118 7189 PMC8293747__F1 Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review 79792 3553 114548 PMC8294576__F3 Mitochondrial metabolism regulates macrophage biology 5979 115004 3661 3091 114548 3553 54106 PMC8295747__F2 Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis 1283 57506 29110 3659 3661 3665 836 PMC8301030__F9 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans 89780 2932 1499 572 1950 367 PMC8301030__F10 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans 2638 650 860 4772 100187907 1513 4280 7054 PMC8301368__F7 Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway 2932 5724 1499 672 PMC8301368__F8 Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway 5724 6714 4318 4313 2932 387 PMC8304001__F1 Prostate Cancer Therapy Enzalutamide Compared with Abiraterone Acetate/Prednisone Impacts Motivation for Exploration, Spatial Learning and Alters Dopaminergic Transmission in Aged Castrated Mice 367 1586 1583 6822 412 PMC8304479__F6 Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145 4893 2475 6774 8651 PMC8305159__F5 Antimelanogenesis Effects of Theasinensin A 4157 4286 7306 PMC8305981__F2 Lysophospholipid Metabolism in Chronic Myelogenous Leukemia Stem Cells 4018 79153 1499 55366 PMC8307460__F1 RelB and Neuroinflammation 3553 5971 4050 7187 PMC8307504__F6 Nuclear Envelope Integrity in Health and Disease: Consequences on Genome Instability and Inflammation 115004 3661 29110 PMC8307885__F2 Nano-Strategies Targeting the Integrin AvB3 Network for Cancer Therapy 25776 1499 6714 835 4680 PMC8310348__F1 Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems 57506 29110 7098 3661 51311 51284 3663 54106 4615 3665 115004 3428 3553 9447 PMC8313741__AF1 miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression 64506 23411 6657 PMC8313741__F8 miR-301 regulates the SIRT1/SOX2 pathway via CPEB1 in the breast cancer progression 64506 23411 6657 PMC8313969__F2 Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment 4088 4087 4092 4089 2932 1499 6347 6352 2263 6774 2475 5728 3091 1956 3570 2002 PMC8316605__F2 Cryo-EM: A new dawn in thyroid biology 7038 7253 1735 1733 1734 7054 7173 7276 PMC8317223__F2 Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook 1557 1565 1576 PMC8320331__F2 Epigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC) 4040 4041 1499 324 8913 5924 595 1846 355 6256 PMC8322984__F9 Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals 140609 114548 3553 PMC8326207__SF2 Lipidomic and transcriptional analysis of the linoleoyl-omega-hydroxyceramide biosynthetic pathway in human psoriatic lesions 7454 204219 7908 26154 126410 285848 7038 79852 121214 PMC8328898__F2 Membrane-Associated Mucins of the Human Ocular Surface in Health and Disease 4615 3654 7189 PMC8329951__F6 Identification of differentially expressed genes in diabetic kidney disease by RNA‐Seq analysis of venous blood platelets 3976 3559 53832 3601 3568 3067 8528 790 1807 PMC8330071__F8 TLR7/8 signalling affects X-sperm motility via the GSK3 A/Beta-hexokinase pathway for the efficient production of sexed dairy goat embryos 7189 2931 2932 51311 PMC8333094__F9 Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic Beta-oxidation 54677 3030 1892 PMC8336719__F1 Roadmap for AHR targeting in skin inflammation 8942 196 405 5017 57491 PMC8345935__F1 New Insights into Cancer Targeted Therapy: Nodal and Cripto-1 as Attractive Candidates 4838 4087 4088 4089 324 4040 4041 1499 2932 6714 PMC8346230__F5 Representative diagram of the molecular interactions among AJUBA, CDH4, and CTNNB1 1499 1002 84962 PMC8347979__F4 ADAM 17 and Epithelial-to-Mesenchymal Transition: The Evolving Story and Its Link to Fibrosis and Cancer 6714 6868 4313 4318 PMC8353812__F10 Characterization and comparative analysis of transcriptional profiles of porcine colostrum and mature milk at different parities 4804 3439 1440 2254 284217 1297 2263 3371 3690 3680 1287 3912 7010 7058 4803 5296 3718 9586 4254 4602 3674 7059 3691 5578 10018 PMC8355060__F1 Transcription Factors CREBH, PPARa, and FOXO1 as Critical Hepatic Mediators of Diet-Induced Metabolic Dysregulation 84699 2932 7038 PMC8355588__F5 Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients 19 9619 335 PMC8359037__F2 Systematic summary of survival and death signalling during the life of hair follicle stem cells 22943 324 1499 PMC8362328__F10 Upregulation of KLK8 Predicts Poor Prognosis in Pancreatic Cancer 11202 1950 1956 2475 PMC8363454__F6 Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NFKB Signaling Pathway 54472 23035 114609 5879 834 PMC8364365__F5 Crucial Roles of Intermediate Metabolites in Cancer 8942 125061 8564 196 PMC8365519__F5 Low-Dose Radiation Can Cause Epigenetic Alterations Associated With Impairments in Both Male and Female Reproductive Cells 388 2316 4088 23020 4609 4666 5426 7157 PMC8367322__F1 LncRNA BANCR in Human Cancers: An Updated Review 324 1499 2932 100885775 595 PMC8371277__F2 Lipid droplets and lipid mediators in viral infection and immunity 7038 4050 4015 PMC8371750__F7 Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study 1021 355 836 842 PMC8372151__F3 Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease—A Pediatric Perspective 8074 5741 2264 PMC8375160__F10 Mutual regulation between chicken telomerase reverse transcriptase and the Wnt/Beta-catenin signalling pathway inhibits apoptosis and promotes the replication of ALV-J in LMH cells 1499 6925 4397 581 PMC8375270__F2 When Viruses Cross Developmental Pathways 4855 4851 4854 4853 PMC8377541__F8 CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/Beta-Catenin Signaling Pathway in Glioma 1378 1380 10023 4040 4041 8313 2932 1499 324 51176 6925 PMC8379308__F1 Herpesviruses and the Type III Interferon System 57506 9439 3665 27063 3661 7098 54106 7216 6772 6773 3454 3716 3717 10379 7297 PMC8380049__F2 Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension 4089 4090 4086 27302 659 PMC8380544__F1 Novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder 64220 7098 51311 54106 51284 2475 1381 PMC8385203__F10 Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2Alpha-Stat3 pathway in diabetic cardiomyopathy 3717 6774 4976 PMC8387591__F1 Mouse Models of Germinal Center Derived B-Cell Lymphomas 7054 4609 896 2308 596 355 2146 100271849 64121 8085 1387 8764 6761 718 54790 10672 4615 974 639 727 604 PMC8387950__F8 FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARA Pathway 2170 5467 31 5465 2645 PMC8389254__F3 Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?” 2475 8408 664 3920 PMC8389593__F1 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway 6770 831 1585 1584 PMC8389593__F2 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway 3762 476 1585 776 8912 PMC8389593__F4 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway 8081 5121 1585 PMC8389606__F2 NFKB and Human Cancer: What Have We Learned over the Past 35 Years? 1540 613 4615 4055 5971 PMC8392110__F1 Targeting STAT3 Signaling Pathway in Colorectal Cancer 1950 10401 9021 6774 6714 PMC8392407__F1 Unraveling the IGF System Interactome in Sarcomas Exploits Novel Therapeutic Options 1969 3479 3480 7018 2050 3481 PMC8392544__F4 Applying Bioinformatic Platforms, In Vitro, and In Vivo Functional Assays in the Characterization of Genetic Variants in the GH/IGF Pathway Affecting Growth and Development 2690 6772 3479 3480 6774 9021 3717 3486 PMC8395197__F8 Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis 7054 5346 63924 2167 9370 PMC8396202__F2 Cell-Free DNA in Rheumatoid Arthritis 3654 3665 54106 4615 51135 7189 115004 29110 3661 9447 3606 PMC8396208__F3 GDF15 and Cardiac Cells: Current Concepts and New Insights 2309 9518 9242 PMC8396570__F1 Putative Role of Vitamin D for COVID-19 Vaccination 6347 6354 3466 54106 7098 51284 51135 3665 3661 7099 6850 7189 29110 114548 PMC8401694__F1 Emerging Role of Nutraceuticals in Cardiovascular Calcification: Evidence from Preclinical and Clinical Studies 1499 54822 860 4086 7128 2863 650 PMC8402745__F4 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges 6772 6774 8651 9021 10865 PMC8408558__AF1 LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/Beta-catenin signaling pathway 2932 1499 4040 6935 6925 27122 27123 6422 693171 643648 PMC8408558__F8 LINC01189-miR-586-ZEB1 feedback loop regulates breast cancer progression through Wnt/Beta-catenin signaling pathway 2932 1499 4040 6935 6422 27122 27123 693171 643648 6925 PMC8408990__F2 Transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes 1636 8703 341 344 346 79135 79759 1191 952 388325 5819 23607 79037 PMC8421619__F1 Investigation of MDMA Inhibitory Effect on CytochromeP450 3A4 in Isolated Perfused Rat Liver Model Using Tramadol 1312 1555 1565 1576 PMC8421956__F3 Basic science of optic nerve regeneration 9021 6774 7248 2475 3976 1270 5728 3479 PMC8422078__F1 Synthesis of GDP‐L‐fucose by the de novo and salvage pathway 8790 282969 51006 55343 2762 2517 7264 23509 PMC8422159__F12 Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NFKB Pathway 7124 4615 7099 55366 PMC8425587__F5 Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review) 8878 2475 51295 7189 7124 9817 PMC8430856__F1 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance 8717 637 581 PMC8431051__F2 Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer 6347 3576 55364 5728 7157 1435 2078 50943 3620 PMC8432036__F2 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies 7046 4092 4087 4088 4089 PMC8437140__F1 The bile acid/FXR pathway by lncRNAs 344 55384 7038 1581 1582 PMC8438004__F1 St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity 5155 7038 4280 2670 PMC8438703__F1 Understanding microglial diversity and implications for neuronal function in health and disease 1524 102 54209 2621 558 PMC8446672__F1 Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis 149233 3717 6774 7297 3662 PMC8446765__F1 Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer 412 1586 8644 PMC8447721__F1 Effective function of circular RNA in colorectal cancer 442906 836 406996 83737 406952 PMC8452875__F7 Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease 406 9575 847 23411 PMC8457844__F2 Classically known renin angiotensin pathway and the inhibitors identified from our high throughput screen 1636 185 186 PMC8463986__F1 Brain insulin resistance: an early risk factor for Alzheimer's disease development in Down syndrome 23411 2932 3667 2475 351 PMC8465606__F7 Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in Abalone Haliotis discus hannai Ino 7187 7099 7189 3661 7097 114609 51135 4615 23118 85451 9618 3553 PMC8466551__F6 Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis 6469 7422 8828 3845 2475 1499 4040 4041 2736 PMC8466912__F3 Inhibition of Cellular and Animal Inflammatory Disease Models by NFKB Inhibitor DHMEQ 7097 7189 3553 7186 PMC8466925__F2 Polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis 3973 367 6462 6770 2492 PMC8466973__F1 High temperature requirement A1 in cancer: biomarker and therapeutic target 5076 1956 331 1950 4851 PMC8467246__F1 Landscape of IFN/ISG Signaling in HIV-1-Infected Macrophages and Its Possible Role in the HIV-1 Latency 4599 4600 3627 9636 60489 11274 3659 51441 56339 3669 57721 54890 PMC8467255__F4 Biological Significance of the Protein Changes Occurring in the Cerebrospinal Fluid of Alzheimer’s Disease Patients: Getting Clues from Proteomic Studies 335 19 9619 3931 64137 3949 1071 64240 337 948 344 PMC8467693__F1 Personalised Medicine for Colorectal Cancer Using Mechanism-Based Machine Learning Models 89780 1499 595 4609 4613 22943 PMC8469349__F7 Wharton’s Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499 1756 4312 4089 4087 4088 PMC8470674__F1 Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives 10020 55907 54187 140838 PMC8471347__F1 NFKB Nucleolar Stress Response Pathway 150684 5970 10763 581 PMC8472231__F6 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells 3856 3123 3117 3875 4067 960 972 3119 2690 330 3122 3665 3115 2113 1969 2260 929 857 2353 3659 3383 PMC8475840__F1 Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection 3099 112398 3313 PMC8479296__AF1 LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway 27161 100505702 389421 PMC8481958__F1 Immunometabolism during inflammaging 9573 114548 2475 3553 952 PMC8486873__F3 DNA damage stress induced the release of immunomodulatory cargoes through EVs 100302142 115004 3661 3553 PMC8487948__F4 Targeting the WNT pathway- inhibitors in clinical trial 79971 4040 4041 64840 324 8658 1499 607 84133 54894 55366 8549 59352 PMC8490443__F4 BMP7 reduces the fibrocartilage chondrocyte phenotype 655 4088 5340 249 4323 4313 5176 1277 338773 6275 57214 PMC8493876__F1 Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation 29851 1803 939 940 958 3902 PMC8495178__F8 N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells 8678 64863 79068 PMC8504268__F1 Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88 114609 4615 7124 3553 929 3929 PMC8504858__F2 Inductive Materials for Regenerative Engineering 4089 4090 4086 4091 50964 860 2932 1499 324 102 6608 51684 PMC8504951__F7 Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway 7422 6774 6714 2247 2260 PMC8505617__F1 The canonical Wnt/Beta-catenin signaling pathway and the interactions between lncRNAs and the pathway 4040 4041 1499 2932 100885798 100506795 100499467 324 112597 PMC8505617__F6 The TGFB signaling pathway and the interaction between lncRNAs and the pathway 7048 4087 4088 7018 4089 7046 728463 PMC8505885__F2 Metabolic Program of Regulatory B Lymphocytes and Influence in the Control of Malignant and Autoimmune Situations 54106 613 6774 3091 196 958 PMC8506081__F2 Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer 1499 23513 9223 6714 PMC8507001__F6 Baicalin promotes chondrocyte viability and the synthesis of extracellular matrix through TGFB/Smad3 pathway in chondrocytes 4088 6662 11096 PMC8508208__F1 Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma 2806 4199 3845 PMC8508869__F1 Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway 2475 6714 6774 PMC8509287__F2 Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis 4615 57506 3661 PMC8511314__F9 Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase 4018 23566 2475 1956 PMC8513284__F10 FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway 1994 10890 7099 1499 PMC8514798__F2 Germline STAT3 gain-of-function mutations in primary immunodeficiency: Impact on the cellular and clinical phenotype 6774 10401 9021 1854 PMC8515020__F1 Hyperinflammatory Immune Response and COVID-19: A Double Edged Sword 7098 114548 3146 7099 79792 6347 6348 6352 6354 920 3458 7054 PMC8515898__F1 Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer 79792 114548 147945 PMC8516775__F6 Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach 1045 4583 9314 10013 PMC8517477__F2 STING Signaling and Sterile Inflammation 3146 115004 3627 PMC8517841__F6 Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway 3716 7297 3717 91607 PMC8518013__F7 Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma 2735 6608 100187761 PMC8525887__F1 Schematic showing regulation of PAI-1 activation and its role in hepatocytes 5340 7448 4072 595 79923 4609 PMC8533819__F3 Involvement of Kynurenine Pathway in Hepatocellular Carcinoma 3570 6774 196 3620 405 50943 PMC8533927__F2 Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers 3845 3480 6790 2260 2064 2065 PMC8534198__F4 Methylosystem for Cancer Sieging Strategy 54890 79068 9589 57721 56339 51441 4837 PMC8536196__F1 Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review 1392 4158 1393 2289 348235 PMC8538279__F5 Microbiomics in Collusion with the Nervous System in Carcinogenesis: Diagnosis, Pathogenesis and Treatment 627 6774 3717 PMC8541492__F1 COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis 4827 1594 120227 PMC8546207__F4 Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development 7097 958 942 941 7124 3553 7412 PMC8548344__F2 Crosstalk between Hedgehog and other pathways in the intestinal tract 6608 2736 2735 7482 8650 64127 1499 PMC8549964__F2 Local delivery of FTY720 induces neutrophil activation through chemokine signaling in an oronasal fistula model 1901 9294 1903 8698 53637 2776 2768 5293 23533 5330 6093 9475 596 5579 PMC8550604__F1 Factor Xa beyond coagulation 7018 2717 7035 PMC8553480__F2 MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer 57510 5901 54487 29102 27161 PMC8555377__F3 High frequency of clonal hematopoiesis in Erdheim-Chester disease 54790 4893 673 3845 1788 7307 2146 5604 23451 PMC8557551__F6 Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D3 is mediated by inhibition of chaperone-mediated autophagy 1594 860 1277 PMC8558176__F1 WNT3 hypomethylation counteracts low activity of the Wnt signaling pathway in the placenta of preeclampsia 2932 324 4040 4041 1499 PMC8558403__F2 Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications 7099 6351 6347 PMC8558653__F5 Mucin 1 promotes tumor progression through activating WNT/Beta-catenin signaling pathway in intrahepatic cholangiocarcinoma 1499 4582 595 4316 PMC8558833__F9 Anatase and Rutile TiO2 Nanoparticles Lead Effective Bone Damage in Young Rat Model via the IGF-1 Signaling Pathway 594857 3480 3479 1513 PMC8568770__F1 Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia 9290 2841 2166 7442 59341 PMC8569443__F1 Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus 3661 57506 3665 3716 6772 10379 3466 7297 6773 100506668 100506779 PMC8569813__F2 Colon Cancer Progression Is Reflected to Monotonic Differentiation in Gene Expression and Pathway Deregulation Facilitating Stage–specific Drug Repurposing 2147 10891 4070 1179 6641 1836 56937 9358 PMC8570281__F1 Genetic Polymorphisms in High-Dose Methotrexate Toxicity and Response in Hematological Malignancies: A Systematic Review and Meta-Analysis 6573 1719 2356 8836 471 4524 7298 PMC8570409__F3 Immunopathology and Immunopathogenesis of COVID-19, what we know and what we should learn 7099 324 3553 3606 51284 3665 3661 7098 10379 4615 23586 7054 920 PMC8573870__F11 Effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons 7124 3569 3553 6774 3565 4087 4088 5178 PMC8575642__F1 Irisin Acts via the PGC-1A and BDNF Pathway to Improve Depression-like Behavior 252995 7350 627 PMC8576247__F4 Clinical values and potential pathways of miR-183-5p in gastric cancer: a study based on integrational bioinformatics analysis 1287 1311 7148 2690 5649 4804 4915 2475 7482 5602 55799 10235 783 166336 1501 PMC8577797__F6 Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway 6774 6868 23241 79651 83939 1956 1950 PMC8577836__F7 Schematic model of the role of tumor-derived extracellular vesicle (TEV) and CD300a in tumor immunity 11314 7098 3661 PMC8580341__F2 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors 2146 84133 54894 10664 2932 8312 324 1499 51701 367 100885798 PMC8580341__F5 Differential expression of long non-coding RNAs as diagnostic markers for lung cancer and other malignant tumors 643401 283131 23411 581 PMC8580647__F4 Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling 7039 7939 4092 4087 4089 860 4086 PMC8581311__F4 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment 2668 5979 2078 PMC8584457__F1 Targeting Inflammatory Signaling in Prostate Cancer Castration Resistance 4050 5971 5533 4212 PMC8584977__F5 Wnt Signaling in Inner Blood–Retinal Barrier Maintenance 727 4040 4041 8322 84879 1499 PMC8585982__F1 CAR-T: a potential gene carrier targeting solid tumor immune microenvironment 941 942 940 920 PMC8586445__F1 T-Cell Metabolism in Graft Versus Host Disease 3099 3098 355 6518 6520 2475 PMC8586819__F2 T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective 1493 9760 8320 11126 3458 7124 51744 201633 PMC8597301__F8 Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis 4280 4615 7099 PMC8599985__F2 Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function 6774 3717 1437 5068 1956 7128 283131 50943 7099 105416157 PMC8600399__F8 MicroRNA-218-5p in sevoflurane-induced protective effects in hepatic ischemia/reperfusion injury mice by regulating GAB2/PI3K/AKT pathway 7124 9846 2475 4280 PMC8600424__F1 New insights into Epstein-Barr virus-associated tumors: Exosomes 7186 967 7251 PMC8606765__F3 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells 940 7097 652070 930 951 4615 958 925 PMC8607366__F3 Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury 147111 11197 4040 4041 324 2932 1499 PMC8608863__F6 Molecular mechanism of Met against HCT116 cells 842 836 841 PMC8611092__F3 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression 84107 4343 3796 6938 PMC8613896__F2 New perspectives on the treatment of hidradenitis suppurativa 3576 6373 114548 6347 6364 7124 2919 6372 PMC8613976__F1 NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity 4615 79792 114548 PMC8616136__F3 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy 367 2932 324 1499 4040 4041 22943 PMC8616136__F6 Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy 22943 1499 324 4040 4041 2932 PMC8616386__F6 Walking down Skeletal Muscle Lane: From Inflammasome to Disease 7099 114548 2693 100313843 79792 51094 PMC8616451__F1 Therapeutic Potential of MRGPRX2 Inhibitors on Mast Cells 117194 90865 4615 PMC8616751__F1 Canonical Wnt pathway and the potentiating effect of RSPO 84133 54894 55366 8549 59352 3725 4040 4041 324 2580 PMC8617635__F9 Riboflavin as a Mucosal Adjuvant for Nasal Influenza Vaccine 969 1236 85451 940 958 920 PMC8619244__F3 TRPV4 Mechanotransduction in Fibrosis 54822 7222 7225 PMC8620049__F2 Influences of Omega-3 Polyunsaturated Fatty Acids on the Development of Skin Cancers 6608 5727 51684 581 PMC8620763__F1 Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study 95 590 5049 5050 54578 1559 348158 PMC8621031__F2 Resveratrol against Cardiac Fibrosis: Research Progress in Experimental Animal Models 4087 4088 23411 PMC8621753__F3 Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells 23410 15 438 23411 PMC8628936__F2 Organizer and Its Signaling in Embryonic Development 4041 324 1499 2932 4838 4087 4088 4089 6714 PMC8630697__F1 Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer 3454 3455 10379 6773 6772 3661 3569 115004 29110 PMC8632547__F4 Hippo Signaling Pathway: The Trader of Tumor Microenvironment 9113 26524 6714 6010 7003 8463 7004 7005 PMC8632642__F8 Co-Exposure of Cardiomyocytes to IFNG and TNFA Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy 6772 23411 4843 PMC8633599__F2 Molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development 4879 2922 2925 83737 PMC8634476__F3 Placental Angiogenesis in Mammals: A Review of the Regulatory Effects of Signaling Pathways and Functional Nutrients 51129 7422 2841 2171 2167 54567 PMC8637543__F2 Zinc Finger Proteins in Neuro-Related Diseases Progression 6935 8462 7593 56650 10365 PMC8637759__F9 Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting 3146 3569 7124 PMC8639599__F2 Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia 9242 7852 6387 51705 960 947 PMC8645845__F2 Novel Implications of MicroRNAs, Long Non-coding RNAs and Circular RNAs in Drug Resistance of Esophageal Cancer 133 693219 25859 55000 103352670 7436 5455 PMC8645898__F2 SOX9: Advances in Gynecological Malignancies 406961 79854 3099 100506810 10381 6662 PMC8648391__F1 Potential synthetic lethal strategy with PARP inhibitors: perspective on ‘Inactivation of the tumor suppressor p53 by long noncoding RNA RMRP’ 6023 6627 4193 PMC8648605__F6 Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma 5873 619501 920 PMC8652015__F4 Molecular mechanism of chronic stress affecting the occurrence and development of breast cancer and potential drug therapy 3480 4923 1958 PMC8656796__F5 Therapeutic Efficacy of Variable Biological Effectiveness of Proton Therapy in U-CH2 and MUG-Chor1 Human Chordoma Cell Death 920 7292 7186 7188 7187 7293 3725 PMC8658239__F2 Important Role of Endothelium and Extracellular Vesicles in the Cellular Mechanism of Aortic Aneurysm Formation 7186 3383 7412 387 4088 4087 PMC8664518__F1 Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective 5228 29949 114548 7908 PMC8669998__F1 Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature 57506 7099 7187 29110 3455 3454 3661 3665 7098 51311 51284 54106 4615 7189 6772 6773 10379 3716 7297 PMC8670233__F2 Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases 2006 4015 10682 PMC8671602__F1 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity 9416 7098 9188 170506 29110 3661 7099 7187 1653 7096 10333 4615 7097 51311 1660 51284 7189 3665 54106 57062 PMC8671602__F3 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity 3428 51428 115004 29118 1660 3661 3454 3455 7297 10379 91351 55601 170506 22907 10521 1656 PMC8671998__F3 Immunogenic ferroptosis and where to find it? 3553 3606 3146 7099 7097 54106 PMC8674574__F2 Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI 7099 11035 50507 26751 197259 581 114548 3553 79792 PMC8674840__F5 ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses 3661 57506 6773 6772 3455 3716 7297 3454 PMC8674954__F8 Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation 958 3566 613 1380 1378 2638 5091 50615 639 PMC8675856__F7 Long non‐coding RNAs and their targets as potential biomarkers in breast cancer 401904 91355 4051 11283 27097 PMC8678517__F2 Novel Pathways for Targeting Tumor Angiogenesis in Metastatic Breast Cancer 4089 4086 4090 4093 27302 7048 4087 4088 10097 PMC8685516__F1 Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases 1499 159296 10913 4090 4086 7187 7189 PMC8687848__F8 Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy 2740 2670 7124 PMC8689983__F3 Reactome pathway knowledgebase 2022 7157 3191 259266 11345 28996 11337 221504 1994 PMC8697421__F1 Inborn errors of immunity underlying severe cutaneous HPV infections 10519 8517 5295 5293 6789 81704 7454 7852 84061 7535 3702 10125 399 3932 27040 920 146206 940 84433 28755 6957 942 941 325 PMC8699088__F2 Senescent Cells in Cancer: Wanted or Unwanted Citizens 2475 2626 115004 3554 PMC8699127__F4 Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm 1499 4040 4041 324 650 4086 4089 PMC8699546__F3 Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation 3146 114609 4615 7099 PMC8699548__F2 Multicellular Effects of STAT3 in Non-small Cell Lung Cancer: Mechanistic Insights and Therapeutic Opportunities 1950 1956 3569 6774 3570 PMC8700621__F1 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease 55510 29760 7026 64805 PMC8703190__F2 Contribution of Smoothened Receptor Signaling in GABAergic Neurotransmission and Chloride Homeostasis in the Developing Rodent Brain 627 6295 6608 PMC8704679__F1 JAK-STAT Pathway: A Novel Target to Tackle Viral Infections 57506 10010 29110 3661 PMC8705692__F1 Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence 7054 1312 4922 1621 5409 PMC8707860__F7 VEGFB Promotes Myoblasts Proliferation and Differentiation through VEGFR1-PI3K/Akt Signaling Pathway 7423 2475 5111 4656 PMC8708448__F1 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective 22943 4041 4040 79971 1499 23043 607 960 4613 595 6927 5468 4316 PMC8708448__F4 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective 6608 374654 51684 2735 2737 2736 PMC8709313__F2 TKI Era in Chronic Leukemias 4067 973 974 5336 6850 29760 695 930 2475 PMC8712397__F1 Tools, Tactics, and Objectives to Interrogate Cellular Roles of O-GlcNAc in Disease 8473 10724 55364 PMC8712487__F2 Myosin 1g and 1f: A Prospective Analysis in NK Cell Functions 9636 64005 4542 3383 PMC8712645__F4 Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy 115004 940 1493 PMC8718055__F6 Inhibition of the NLRP3/IL‐1B axis protects against sepsis‐induced cardiomyopathy 114548 3553 3554 PMC8718194__F1 Crosstalk between the caspase family and the cGAS‒STING signaling pathway 3661 3665 115004 581 6778 PMC8722298__F2 Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer 7103 7832 7049 PMC8738868__F4 Emerging commonalities of circRNA-mediated signaling pathways 324 2932 1499 79923 103611090 PMC8741925__F7 Mechanical stress dampens the CR, resulting in the degeneration of IVDs through the Rho/ROCK pathway 4314 387 4318 4322 9507 406 9575 PMC8743723__F8 Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/Beta-catenin pathway by directly binding to aldolase A 1499 2932 324 226 595 4316 PMC8743908__F2 Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease 8564 130013 23410 23411 PMC8745251__F1 Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles 1581 1582 6718 1109 1593 80270 9420 PMC8745615__F3 Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins 10221 64326 28951 PMC8750110__F5 Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success? 115004 3661 5167 7124 PMC8750188__F3 Identification of Let-7 miRNA Activity as a Prognostic Biomarker of SHH Medulloblastoma 4613 79727 389421 PMC8750516__F1 Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer 637 581 572 8739 638 90427 PMC8754418__F1 Congenital Micropenis: Etiology And Management 27123 367 1499 6667 PMC8755999__F1 Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management 6770 1583 2232 2230 3284 1585 5447 1589 1586 6715 1528 6716 8644 PMC8758946__F1 Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation 8022 4009 4487 5080 10716 5979 PMC8759629__F1 MICROGLIA AS THERAPEUTIC TARGETS AFTER NEUROLOGICAL INJURY: Strategy for Cell Therapy 3596 7124 2539 PMC8760698__F2 Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension 659 3611 4851 5209 4609 5053 8862 3162 4846 PMC8761737__F8 Transcriptomic and Histological Analysis of Exacerbated Immune Response in Multidrug-Resistant Pseudomonas aeruginosa in a Murine Model of Endophthalmitis 4280 7124 7189 4353 7078 7077 2670 114548 PMC8761794__F1 CGAS/STING Pathway: A Novel Target for Cancer Therapy 3661 3627 6352 4938 6773 6772 7124 29110 3455 3454 PMC8761794__F2 CGAS/STING Pathway: A Novel Target for Cancer Therapy 115004 6573 3627 6373 4843 7124 PMC8761794__F3 CGAS/STING Pathway: A Novel Target for Cancer Therapy 115004 3661 29110 PMC8764250__F3 Interleukin 27 Signaling in Rheumatoid Arthritis Patients: Good or Evil? 3383 3716 7297 6772 2625 920 PMC8764452__F2 Emerging Role of Cancer-Associated Fibroblasts-Derived Exosomes in Tumorigenesis 975 928 6469 4313 PMC8766410__F3 Adenosinergic Signaling as a Key Modulator of the Glioma Microenvironment and Reactive Astrocytes 84890 135 100 134 136 140 PMC8770421__F2 Versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function 650 652 654 27302 659 92 93 2022 4086 4090 4093 4089 4091 4092 PMC8771846__F7 RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways 7124 57381 5062 10298 PMC8773517__F2 Oxysterols in the Immune Response to Bacterial and Viral Infections 9023 1880 3661 3665 1593 PMC8774449__F1 Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases 1717 120227 1576 1591 PMC8775422__F4 Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside 1499 4040 4041 324 PMC8781800__F3 Current Aspects on the Pathophysiology of Bone Metabolic Defects during Progression of Scoliosis in Neurofibromatosis Type 1 4763 4087 4088 4089 PMC8786287__F3 Metabolic adaptation of super-complexes 4976 468 58506 PMC8786807__F7 Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell 2908 2288 100187761 PMC8789115__F5 Graphlet adjacency captures centrality of cancer driver genes in the FSAHF pathway 57634 7157 7290 3005 29855 8091 3159 5925 23523 PMC8789313__F2 Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives 64127 5091 85480 55223 8915 149233 5771 PMC8794704__F2 Inflammasome and Its Therapeutic Targeting in Rheumatoid Arthritis 9447 81559 58484 3553 170 PMC8797967__F8 Knockdown of ferritin heavy chain (FTH) inhibits the migration of prostate cancer through reducing S100A4, S100A2, and S100P expression 6273 8178 6275 6286 PMC8802892__F5 Transcriptomic and Metabolomic Analyses Reveal Inhibition of Hepatic Adipogenesis and Fat Catabolism in Yak for Adaptation to Forage Shortage During Cold Season 6319 3949 4023 2167 7038 3479 PMC8803838__F2 Neutrophils in chronic inflammatory diseases 3384 2920 2919 3606 4353 3553 57126 50616 114548 260431 1511 PMC8804383__F7 Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition 3553 4088 4087 PMC8804851__F8 Shockwave Treatment Enhanced Extracellular Matrix Production in Articular Chondrocytes Through Activation of the ROS/MAPK/Nrf2 Signaling Pathway 176 1280 1728 PMC8807488__F3 Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor 641638 440823 54487 93986 894 100506826 6934 55384 PMC8807488__F4 Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor 5971 2736 2737 51684 PMC8807567__F1 Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance 9575 406 1628 PMC8809118__F7 NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria 50507 23411 9817 467 468 51176 6925 6929 PMC8810792__F7 Transcriptome of human neuroblastoma SH-SY5Y cells in response to 2B protein of enterovirus-A71 9235 6347 5327 9536 3604 7124 330 5971 PMC8814438__F7 Kinsenoside Protects Against Radiation-Induced Liver Fibrosis via Downregulating Connective Tissue Growth Factor Through TGFB1 Signaling 4087 4088 7040 PMC8814816__F1 Targeting cholesterol homeostasis in hematopoietic malignancies 22937 19 9619 PMC8814816__F2 Targeting cholesterol homeostasis in hematopoietic malignancies 4598 9023 1593 10858 PMC8822281__F6 miR-3132 upregulates surface TRAIL to induce apoptotic cell death in cancer cells 100423039 4615 29110 10379 3661 PMC8822417__F8 Activation of PPARG in bladder cancer via introduction of the long arm of human chromosome 9 3169 2625 5468 5728 PMC8824753__F2 Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression 7099 4615 114548 24145 9447 3553 3596 201633 6280 634 PMC8826423__F1 Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification 100505633 324 1499 595 4316 100302161 1869 27161 2919 9052 PMC8828488__F1 ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis 114548 10628 1267 3553 960 PMC8831326__F7 Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart 2660 4087 4088 4089 PMC8835057__F6 Cytokine Receptors—Regulators of Antimycobacterial Immune Response 149233 7297 3717 6772 6774 6775 PMC8835572__F4 Cancer as a Metabolic Disorder 55902 3949 355 47 948 2475 PMC8836182__F2 Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC 1499 51176 6925 PMC8838156__F1 Toll-like Receptor 4, Osteoblasts and Leukemogenesis; the Lesson from Acute Myeloid Leukemia 4615 7189 7099 929 3661 PMC8841354__F5 Interleukins and Ischemic Stroke 6778 3553 3606 29949 920 6761 90865 PMC8841526__F8 Identification of Key Genes Related With Aspartic Acid Metabolism and Corresponding Protein Expression in Human Colon Cancer With Postoperative Prognosis and the Underlying Molecular Pathways Prediction 290 10637 3397 440 1555 1050 4149 PMC8842603__F1 Tankyrase Inhibitor for Cardiac Tissue Regeneration: an In-silico Approach 324 1499 4040 4041 8658 PMC8843880__F6 Tumor microenvironment pathways: Cross regulation in breast cancer metastasis 1499 4609 595 960 4318 4851 6662 PMC8848383__F8 Activation of the AKT/GSK-3B/Beta-catenin pathway via photobiomodulation therapy promotes neural stem cell proliferation in neonatal rat models of hypoxic-ischemic brain damage 4827 4791 1499 595 4609 PMC8850700__F1 LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer 503639 2146 1499 2475 PMC8850700__F2 LncRNA DUXAP10 Could Function as a Promising Oncogene in Human Cancer 503639 2863 1499 2475 PMC8851748__F1 Viral and cellular oncoproteins inhibit the cGAS/STING pathway 115004 29110 3661 PMC8855827__F5 Integrative OMICS Data-Driven Procedure Using a Derivatized Meta-Analysis Approach 5595 5594 2776 3717 4914 3716 1956 3082 55620 6774 9021 6773 6777 6775 6778 64332 5753 3356 PMC8862564__F4 Germline specification from pluripotent stem cells 652 7022 63978 5015 64321 8320 PMC8863938__F5 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers 3550 581 331 PMC8868465__F2 Uncoupling Proteins: A Systematic Review on the Mechanism Used in the Prevention of Oxidative Stress 7350 7351 7352 7216 PMC8869474__F1 Tipping the Balance: Vitamin D Inadequacy in Children Impacts the Major Gut Bacterial Phyla 1717 1591 120227 1594 7421 PMC8869528__F1 Insights into the Role of Gremlin-1, a Bone Morphogenic Protein Antagonist, in Cancer Initiation and Progression 4089 4090 4086 4091 PMC8869911__F4 Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence 2932 1499 595 6608 PMC8870390__F1 Precision Targets for Intercepting the Lethal Progression of Prostate Cancer: Potential Avenues for Personalized Therapy 367 3716 6774 3570 5728 PMC8872619__F2 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells 891 5933 993 890 2305 618 6935 1870 283120 1956 PMC8874480__F2 JAK2 in Myeloproliferative Neoplasms: Still a Protagonist 4352 3717 6774 PMC8875594__F1 PCSK9 Promotes Cardiovascular Diseases: Recent Evidence about Its Association with Platelet Activation-Induced Myocardial Infarction 3949 255738 3552 6714 948 PMC8875910__F1 Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers 4067 6850 695 8011 5894 114609 4615 PMC8877508__F1 Relevance of TLR8 in Viral Infections 51311 51284 3661 3665 4615 7189 PMC8881489__F1 Radiotherapy: Brightness and darkness in the era of immunotherapy 940 941 942 3146 115004 3627 4283 6373 PMC8883486__F1 Canonical and non-canonical NFKB pathway 3569 4055 5971 PMC8885406__F3 XPO1 mediated emergent drug resistance pathways 7153 6418 1499 PMC8886744__F1 Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease 5467 5468 335 5465 PMC8892735__F1 Long and short non-coding RNAs modulating EZH2 signaling in cancer 8726 23512 2146 PMC8899336__F2 Wnt signaling in biliary development, proliferation, and fibrosis 2249 652 3082 PMC8899398__F3 Lactoferrin: A Nutraceutical with Activity against Colorectal Cancer 581 317 637 PMC8899988__F12 Novel HDAC11 inhibitor potentiates the tumoricidal effects of cordycepin against malignant peripheral nerve sheath tumor through the Hippo signaling pathway 7003 6667 81930 PMC8900014__F1 Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway 7297 4397 6773 3454 3455 10379 163702 3459 3460 3717 PMC8900217__F1 DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling 115004 3661 29110 PMC8900732__F1 The Cannabinoid System in the Basal Ganglia in Parkinson’s Disease 2821 9290 7442 PMC8904960__F1 Non-Canonical Roles of Apoptotic Caspases in the Nervous System 355 637 581 317 PMC8908266__F1 Deubiquitinases in Virus Replication and Host Innate Immune Response 55611 7097 7096 10333 7100 78990 90268 4615 7189 51311 54106 51284 220213 7187 29761 10869 9099 7874 29110 3661 3665 7398 9958 7375 10379 10713 23252 11274 10868 54726 8975 389856 25862 115004 1540 PMC8909980__F6 Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3 11213 5970 4615 51135 3654 7189 7099 7124 3569 PMC8910032__F6 Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis 7535 940 920 10454 6774 PMC8913504__F3 Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases 3716 3560 2475 3559 50943 PMC8920443__F37 2022 WHO Classification of Adrenal Cortical Tumors 3762 476 8912 776 492 4158 PMC8927965__F2 Dysregulation of Survivin-Targeting microRNAs in Autoimmune Diseases: New Perspectives for Novel Therapies 5728 5266 1871 6774 4087 4088 7040 51460 PMC8932232__F1 Store-operated Ca2+ entry in cardiovascular disease 6786 84876 3596 PMC8933076__F3 Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases 6347 8213 10858 PMC8934394__F1 Interaction Between Non-Coding RNAs and Calcium Binding Proteins 51719 2475 406901 114548 100302116 PMC8935059__F9 Mitochondria Related Cell Death Modalities and Disease 8517 3551 4792 4790 5970 768 PMC8935220__SF1 Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2 9817 4094 1728 PMC8939123__F1 Sirtuin family members in chronic obstructive pulmonary disease 1499 51548 22933 51547 5225 407040 114548 6774 23409 PMC8945019__F5 Immunosuppressive Signaling Pathways as Targeted Cancer Therapies 6469 5727 2735 51684 6608 2736 2737 PMC8946707__F1 Understanding the Notch Signaling Pathway in Acute Myeloid Leukemia Stem Cells: From Hematopoiesis to Neoplasia 4855 4851 4854 4853 PMC8949960__F1 Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training 3479 2475 3480 253260 238 4087 4088 3569 PMC8949960__F2 Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training 3479 3480 2475 3569 238 4087 4088 PMC8955086__F6 Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy 114548 58484 79792 PMC8957418__F3 Progress of Statin Therapy in the Treatment of Idiopathic Pulmonary Fibrosis 7039 387 6010 PMC8958883__F1 Wnt/Beta-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma 324 8312 2932 1499 4040 4041 PMC8959654__F2 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC 100885798 1499 619501 6932 PMC8959654__F3 LncRNAs Mediating Wnt/Beta-Catenin Signaling in HCC 619501 84793 22943 PMC8960399__F2 Proposed signaling pathways underlying the antidepressant-like actions of arketamine and TGFB1 7046 7048 627 PMC8966131__F4 Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics 3929 929 7124 718 5806 PMC8971670__F5 Targeting Oncoproteins for Degradation by Small Molecule-Based Proteolysis-Targeting Chimeras (PROTACs) in Sex Hormone-Dependent Cancers 367 7113 2289 PMC8972670__F1 Characteristics of NLRs 22861 338322 64127 114548 7124 PMC8980082__F4 LncRNAs in the regulation of pyroptosis in NSCLC 7099 4615 5970 114548 7503 3606 79792 PMC8981326__F5 Glycosphingolipid-Glycan Signatures of Acute Myeloid Leukemia Cell Lines Reflect Hematopoietic Differentiation 861 2623 2122 8706 8702 10724 2529 10690 10402 4602 PMC8982327__F5 Targeting transforming growth factor‐B signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin 7042 5728 4089 4087 4088 PMC8989865__F7 TGFB activates NLRP3 inflammasome by an autocrine production of TGFB in LX-2 human hepatic stellate cells 114548 50507 3606 PMC8990771__F2 Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer 2475 1956 1950 7039 6774 2885 PMC8992442__F2 Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance 472 3717 3845 171023 PMC8995882__F2 Construction Immune Related Feed-Forward Loop Network Reveals Angiotensin II Receptor Blocker as Potential Neuroprotective Drug for Ischemic Stroke 388372 9560 6351 6352 6348 6355 6347 3586 6356 1234 3552 729230 1232 3587 3588 3554 3556 7850 3576 6387 3558 3565 3577 3579 3559 3560 3561 112744 3605 2833 7852 3566 23765 84818 3596 7124 7046 7048 94 3597 3598 PMC8996539__F4 Neutrophil degranulation and myocardial infarction 4313 4312 4314 4316 4322 5340 948 4318 PMC8997990__F6 FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells 2308 6440 6439 PMC8998102__F3 Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism 655 3606 114548 4280 79792 PMC8998143__F2 Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review 7157 4286 434 PMC8998820__F4 Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway 4615 3553 115004 6761 171389 58484 PMC9002353__F7 mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder 2475 2932 1387 6352 PMC9008213__F2 Two-Faced Role of Autophagy in Endometrial Cancer 2475 84938 54986 7157 PMC9010412__F6 SNORD1C was upregulated in CRC, which activated the canonical Wnt/Beta-catenin pathway and promoted the development of cancer stem cells 1499 6932 367 6657 PMC9010746__F1 Controlling neural territory patterning from pluripotency using a systems developmental biology approach 4087 4088 4838 4090 4086 28514 3714 4149 4827 PMC9010822__F5 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances 6469 84976 6608 55733 PMC9011276__F2 Narrative review of the role of the Notch signaling pathway in rheumatoid arthritis 4855 4853 4851 4854 28514 10683 54567 PMC9015684__F1 Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants 1956 6714 5728 1950 PMC9016245__F3 Mitochondria signaling pathways in allergic asthma 3276 4087 4088 PMC9018712__F10 Compound mutant phenotypes of Vangl2, Grhl3, Usp39, and Ube1 genes during mouse development and schematic model of USP39/GRHL3 complex in the de-ubiquitination pathway 10713 57216 57822 144165 PMC9019781__F1 WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease 7428 405 2056 7490 PMC9019922__F5 DSPP signalling during dentineogenesis and dentine regeneration 4090 4086 7018 107048980 4089 1834 107966124 847 649 2002 PMC9020200__F3 Cardiovascular informatics: building a bridge to data harmony 29993 9693 3313 8834 6667 25813 PMC9027478__F1 Notch signaling network in muscle stem cells during development, homeostasis, and disease 28514 5081 3516 54567 PMC9031400__F3 Tumor Microenvironment in Glioma Invasion 3569 6774 2668 PMC9032069__F7 Ginsenoside Rh4 Suppresses Metastasis of Gastric Cancer via SIX1-Dependent TGFB/Smad2/3 Signaling Pathway 1431 6495 4087 4088 4089 PMC9032991__F8 Pharmacogenetics of Osteoporosis: A Pathway Analysis of the Genetic Influence on the Effects of Antiresorptive Drugs 23590 1588 1543 5229 2339 2342 2224 PMC9033806__F8 Schematic model illustrates the potential mechanisms by which GXYLT1 and GXYLT1S212* promote the metastasis of CRC 283464 3280 727936 1956 PMC9034118__F1 Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma 51684 5727 2735 2737 2736 6608 6469 PMC9038718__F7 Mechanism by which LINC00858 affects colon cancer 170425 57092 6774 PMC9040700__F1 High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons 7097 4615 7099 3146 2475 PMC9044756__F10 Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer 324 1499 8204 8602 PMC9045983__F6 Histone Methyltransferase SETDB1 Promotes Immune Evasion in Colorectal Cancer via FOSB-Mediated Downregulation of MicroRNA-22 through BATF3/PD-L1 Pathway 9869 2354 55509 PMC9047859__F2 Functions of Stress-Induced Lipid Droplets in the Nervous System 2194 347 348 23259 PMC9053805__F5 In silico identification of novel biomarkers for key players in transition from normal colon tissue to adenomatous polyps 951 931 5788 10457 929 3119 3113 1439 3587 7124 6774 57823 969 6418 3845 PMC9059101__F11 Critical and Diverse Roles of CD4–CD8– Double Negative T Cells in Nonalcoholic Fatty Liver Disease 948 3002 920 3605 PMC9061994__F4 ROS-Influenced Regulatory Cross-Talk With Wnt Signaling Pathway During Perinatal Development 324 2932 1499 PMC9062296__F8 Endolymphatic Hydrop Phenotype in Familial Norrie Disease Caused by Large Fragment Deletion of NDP 23554 4041 8322 PMC9066210__F4 Biological roles and clinical significance of estrogen and androgen receptors in head and neck cancers 3169 3486 367 3479 PMC9067156__F9 UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines 6615 7358 5465 5159 23659 PMC9068303__F8 N-((1-(4-Fluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methylene-3-oxo-olean-12-en-28-amide Induces Apoptosis in Human Breast Cancer Cells by Stimulating Oxidative Stress and Inhibiting the Notch-Akt Signaling Pathway 891 595 6774 2475 PMC9068916__F7 SP1-mediated oncogenic mechanism in CRC progression 6667 693122 22992 55000 PMC9072012__F3 CTNNB1 in Endometrial Cancer 1499 324 2932 PMC9076607__F2 OPG-related signaling pathways 7187 7186 7189 7188 4772 7450 1499 2932 PMC9084533__F8 Role of OPTN on myogenesis during muscle regeneration 324 1499 2932 10133 4656 PMC9090500__F7 Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction Monocytes 114548 3606 7128 PMC9095352__F7 Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism 6469 5727 6608 2735 51684 PMC9095829__F10 TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases 3579 7222 7224 133 PMC9096207__F3 Transcoelomic Ecosystem and Epithelial Ovarian Cancer Dissemination 960 3082 4854 3161 10631 PMC9099786__F2 Dissecting the Functional Role of the TRIM8 Protein on Cancer Pathogenesis 81603 10401 6774 3716 3458 PMC9100382__F3 Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies 19 51454 84466 23410 22933 23411 51548 10082 6774 3146 PMC9100923__F1 Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure 4524 4552 4548 635 10400 PMC9101816__F5 Non-Cytokine Protein Profile of the Mesenchymal Stem Cell Secretome That Regulates the Androgen Production Pathway 114770 3240 3263 1191 335 1281 197 1462 60 1073 1956 4313 5829 351 558 1586 1950 2247 6714 5604 57706 1583 PMC9102229__F7 Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon Response in Models of Oncolytic Therapy by Vesicular Stomatitis Virus 1956 3661 6774 6772 PMC9105027__F1 Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis 4087 4088 4089 7039 1956 1839 10216 PMC9106457__F5 Exosomes in Chronic Liver Disease Development and Their Potential Clinical Applications 4397 283120 4089 6778 PMC9106713__F1 Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway 1737 2230 540 2242 1317 PMC9106715__F8 Working model displays the mechanism of which RP1-59D14.5-modulated PCa tumorigenesis and progression 9113 26524 7003 8463 7004 7005 PMC9108399__F1 Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRA) in Cancers 2668 4902 9048 2674 2675 64096 2676 5979 5623 2821 PMC9110832__F1 Involvement of Caspases in Neuroinflammation and Neuronal Apoptosis in Chronic Pain and Potential Therapeutic Targets 7442 7124 6366 2833 3553 PMC9114355__F1 Adipose Tissue Derived Exosomes in Metabolic Disease 967 975 928 PMC9117016__F9 Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-Gamma-Mediated Suppression of the NFKB and MAPK Pathways 4280 4772 7189 100187907 1513 PMC9119763__F7 Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway 55669 9927 2335 PMC9120413__F7 Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome 4615 114548 3553 301 PMC9121494__F1 Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer 9575 406 4862 9572 6096 6095 PMC9123899__F2 Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) 3458 6774 7850 3553 PMC9124571__F2 Immune cells in cardiac repair and regeneration 729230 6347 6354 3586 3606 3605 3565 10461 920 PMC9124882__F2 Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands 51284 7189 3665 54106 7098 4615 3569 7099 3661 PMC9125181__F7 Endothelial Beta-Catenin Deficiency Causes Blood-Brain Barrier Breakdown via Enhancing the Paracellular and Transcellular Permeability 8322 4040 4041 1499 84879 857 83483 PMC9125939__F8 NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway 50507 4772 100187907 PMC9125963__F2 Mechanisms involved in controlling RNA virus-induced intestinal inflammation 51284 4615 3654 7187 7098 3665 1653 170506 9188 57506 29110 3661 1665 56919 1660 171389 10000 83666 PMC9130726__F1 Molecular signaling pathways, pathophysiological features in various organs, and treatment strategies in SARS-CoV2 infection 3553 3606 7124 PMC9131252__F1 Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation 2064 387 2475 2066 PMC9132697__F2 Mechanisms Involved in Gut Microbiota Regulation of Skeletal Muscle 3479 2475 2309 9665 PMC9132726__F1 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium 6608 51684 2737 2736 6469 PMC9134343__F3 Controversial Role of IL-33 in Lung Cancer 3002 4615 6761 90865 50943 PMC9134657__F2 New therapeutic targets in ovarian cancer through identifying significantly non-mutated genes 55503 57619 26036 10716 83696 6597 54014 11214 163590 10987 PMC9137930__F4 Flavonoids-Based Delivery Systems towards Cancer Therapies 581 317 637 PMC9138541__F9 CAST as a Potential Oncogene, Identified by Machine Search, in Gastric Cancer Infiltrated with Macrophages and Associated with Lgr5 59350 823 8321 8324 340419 84328 824 7472 7474 7471 7855 8549 831 8325 6422 7473 7482 8326 89780 PMC9139716__F3 Brain Organization and Human Diseases 6469 5727 2735 6608 9241 4090 4086 4089 4838 6496 2260 PMC9141076__F3 An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis 196 405 1543 4772 PMC9141761__F2 Biliverdin Reductase A in the Regulation of Insulin Signaling in Metabolic and Neurodegenerative Diseases: An Update 23621 351 3667 PMC9142523__F7 Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation 7099 114548 3553 4312 PMC9152184__F2 Update in TIGIT Immune-Checkpoint Role in Cancer 920 201633 2625 3662 10666 50943 PMC9162455__F2 Down-regulation of MHC-II antigen presentation pathway by tumour cells and possible therapeutic targets 4609 4261 1956 1387 2146 3458 3660 6772 3122 972 PMC9162468__F2 Therapeutic strategies to induce mitophagy 8408 65018 84749 PMC9166799__F5 Secreted ARSs function in cancer 355 3735 8565 7453 833 2617 7097 10333 6897 1004 3579 3577 1003 PMC9170606__F2 Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review 10654 4597 2224 4598 PMC9173833__F35 SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 3569 3596 7124 3659 PMC9173833__F6 SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1 3569 3596 7124 3659 PMC9179518__F1 Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function 340419 948 55366 50507 7424 PMC9181096__F11 Ginsenoside Rc Promotes Bone Formation in Ovariectomy-Induced Osteoporosis In Vivo and Osteogenic Differentiation In Vitro 1499 324 2932 860 PMC9181737__F2 Molecular Insight into the Therapeutic Effects of Stem Cell-Derived Exosomes in Respiratory Diseases and the Potential for Pulmonary Delivery 7099 3551 8323 8078 PMC9182524__F6 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer 4851 102 79923 6662 100188776 595 PMC9184702__F6 Effect of D-Met supplementation on the milk protein synthesis pathway 2597 5266 2475 1974 PMC9189280__F7 Curcumin Blocks High Glucose-Induced Podocyte Injury via RIPK3-Dependent Pathway 11035 197259 8737 PMC9189314__F2 Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis 10628 79792 3553 PMC9201572__F15 Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGFB/Smads Signal Transduction 6497 64750 4087 4088 4089 4092 7431 57154 PMC9204905__F6 Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer 6817 6818 6822 10941 54657 54659 1577 1571 54575 54658 1543 1565 1555 27284 1551 1558 6783 1557 1559 51478 3292 412 3293 1312 1544 1576 10720 PMC9213082__F8 Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression 2621 558 8651 7099 4615 7189 PMC9214686__F4 Transport and metabolism of cGAMP 929 5167 115004 57864 PMC9219473__F6 Iturin A Rescued STb-R-Induced Pork Skeletal Muscle Growth Restriction through the Hypothalamic-Pituitary-mTORC1 Growth Axis 2691 3479 3667 1977 PMC9219854__F2 Importance and Value of Porcine Species in Sialic Acid Research 6480 84620 27090 10610 81849 55808 30815 256435 10020 8869 6487 6482 10402 6483 6484 338596 6489 51046 7903 29906 8128 54187 140838 55907 PMC9221318__F4 Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction 6608 2736 2735 2737 5727 387 6714 5879 2475 PMC9224119__F1 TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer 7099 4615 7096 7097 10333 7189 3663 7100 51311 54106 51284 3665 3661 7098 7187 PMC9228816__F2 Beyond Moco Biosynthesis―Moonlighting Roles of MoaE and MOCS2 7498 7018 27304 51562 6821 351 4338 PMC9228918__F7 ATM Pathway Is Essential for HPV–Positive Human Cervical Cancer-Derived Cell Lines Viability and Proliferation 11200 472 672 PMC9231801__F2 Three stages of immunological pathway leading to mortality in COVID-19: Stage I (Initiation), with early induction of predominant chemokines upon SARS-CoV-2 infection and viral sepsis 729230 6347 6352 6348 3552 7124 1234 PMC9237949__F1 Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell 3135 3805 6850 4067 2885 759 PMC9241025__F3 Gene Regulatory Circuits in Innate and Adaptive Immune Cells 6097 3516 7054 22806 6775 90865 6778 2625 6774 PMC9243104__F7 Graphical abstract of WASp:RPA alliance in genome stability 54465 7454 11073 PMC9243315__F3 Paradoxical roles of miR-4295 in human cancer: Implications in pathogenesis and personalized medicine 864 4884 1499 694 100422909 5784 2262 8626 1956 PMC9244687__F2 Prolactin: The Third Hormone in Breast Cancer 3717 5617 6776 6714 PMC9246413__F2 Temozolomide – Just a Radiosensitizer? 545 472 4255 4350 PMC9248441__F2 Understanding the Potential and Risk of Bacterial Siderophores in Cancer 3934 581 355 1649 PMC9248717__F1 Wnt Signaling in Postnatal Tooth Root Development 4040 4041 324 1499 PMC9248759__F6 Is Estrogen a Missing Culprit in Thyroid Eye Disease? Sex Steroid Hormone Homeostasis Is Key to Other Fibrogenic Autoimmune Diseases – Why Not This One? 3479 3480 100187761 PMC9251145__F9 Salvianolic Acid B Attenuates Iopromide-Induced Renal Tubular Epithelial Cell Injury by Inhibiting the TLR4/NFKB/NLRP3 Signaling Pathway 7099 4615 5970 5966 114548 3603 581 PMC9251357__F2 Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites 114548 3553 79792 4814 PMC9251686__F7 Receptor interacting protein 1 knockdown induces cell death in liver cancer by suppressing STAT3/ATR activation in a p53-dependent manner 8737 619501 6774 11073 545 PMC9254110__F7 FOXF2 oppositely regulates stemness in luminal and basal-like breast cancer cells through the Wnt/beta-catenin pathway 2295 8202 8321 613 9611 8841 7018 7042 PMC9256000__F3 Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung 284340 3458 84868 4283 58191 629 51284 146722 6367 3557 10563 3552 10682 PMC9256556__F2 TNF in the liver: targeting a central player in inflammation 8717 7186 7188 7185 717 PMC9256749__F4 Piezo1 channel promotes the tumorigenesis of prostate through the Akt/mTOR pathway (adapted from 111) 9780 595 1019 2475 PMC9259834__F1 Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies 2475 4089 4087 10468 4397 1634 4088 2660 PMC9260392__F1 Targeting Novel Regulated Cell Death: Pyroptosis, Necroptosis, and Ferroptosis in Diabetic Retinopathy 114548 3553 79792 PMC9265395__F3 Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator? 5927 1021 4609 5728 PMC9265562__F3 Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease 65018 664 23770 10133 139341 23786 PMC9265592__F1 Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway Modulators, from Current Insights to Future Perspectives 1901 2475 6774 9294 1903 8698 53637 PMC9266763__F2 Revisiting Regulated Cell Death Responses in Viral Infections 3606 114548 79792 3146 1540 7186 7187 8737 11035 PMC9266809__F6 miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR 9759 7528 2475 PMC9274491__F8 RASAL2 mediated the enhancement of YAP1/TIAM1 signaling promotes malignant phenotypes of pancreatic ductal adenocarcinoma 9462 10413 7074 PMC9276080__F2 MicroRNAs and their signaling pathway in mycosis fungoides 115352 6774 23476 648 PMC9276970__F9 Extracellular Nucleosomes Accelerate Microglial Inflammation via C-Type Lectin Receptor 2D and Toll-Like Receptor 9 in mPFC of Mice With Chronic Stress 29121 54106 4615 834 114548 3553 PMC9277484__F3 Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland 5727 2737 51684 1896 10913 6608 2066 2255 3480 10718 3667 8660 652 PMC9277795__F8 circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3 220 27161 2475 PMC9277879__F2 Gut–liver axis in sepsis: interaction mechanisms and therapeutic potential 7099 4615 3569 3929 PMC9284214__F1 Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections 2520 3661 1311 PMC9284696__F4 Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration 9021 10468 2353 7040 91 10365 7048 894 2308 5594 4087 PMC9285118__F1 Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer 3553 79792 114548 PMC9288030__F2 Noncoding RNAs as sensors of tumor microenvironmental stress 7124 3553 6932 378938 57291 100303491 60674 105416157 100124700 PMC9288680__F10 Macrophage-derived apoptotic vesicles regulate fate commitment of mesenchymal stem cells via miR155 4087 632 860 406947 PMC9289165__F2 Targeting CD47 as a Novel Immunotherapy for Breast Cancer 140885 961 920 PMC9293977__F5 Bone remodeling: an operational process ensuring survival and bone mechanical competence 2050 2048 2475 PMC9294223__F8 Inhibition of Notch Signaling Stimulates Osteoclastogenesis From the Common Trilineage Progenitor Under Inflammatory Conditions 1513 100187907 942 PMC9294349__F2 Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway 3596 57506 29110 3661 3665 9636 4939 3553 1283 PMC9294386__F2 HIF-1A in Osteoarthritis: From Pathogenesis to Therapeutic Implications 650 664 2056 3162 6662 PMC9295051__F4 High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential 3159 581 100750247 2146 4851 6774 PMC9304701__F1 Trained Immunity and HIV Infection 7099 3480 19 PMC9305853__F4 Global analysis of differential gene expression within the porcine conceptus transcriptome as it transitions through spherical, ovoid, and tubular morphologies during the initiation of elongation 3458 6387 2263 2255 3553 5054 3480 5350 3479 2252 7040 7043 7939 PMC9307950__F4 Sex-biased adaptive immune regulation in cancer development and therapy 3292 5916 7099 54106 51284 920 6462 367 6932 PMC9312434__F3 Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury 6714 6774 2932 4067 PMC9312989__F3 Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies 6422 6423 54894 4609 6424 6425 2932 324 11197 83439 1499 6932 4041 4040 6934 8312 139285 7088 7090 22943 27122 7089 7091 27123 27121 PMC9315443__F5 Revolution of CAR Engineering For Next-Generation Immunotherapy In Solid Tumors 3665 940 4615 958 29851 939 PMC9316401__F1 Association between Leptin (G2548A) and Leptin Receptor (Q223R) Polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University 3717 9021 6774 PMC9316955__F2 Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity 3091 3586 3553 PMC9320947__F1 Contemporary Concise Review 2021: Interstitial lung disease 4316 4854 1277 59 PMC9324963__F2 IL‐22 in homeostasis and diseases of the skin 6774 3716 7297 6772 2475 PMC9331192__F2 Chicken Prolactin, Growth Hormone and Their Receptors in the Immune System 2690 3717 3479 PMC9338328__F2 Radiotherapy combined with immunotherapy: the dawn of cancer treatment 6774 50943 4088 4089 4092 PMC9340222__F2 Traditional Chinese Medicine in the Treatment of Chronic Kidney Diseases: Theories, Applications, and Mechanisms 4088 4092 1243 114548 2475 1499 PMC9340325__F2 Cell secretomes for wound healing and tissue regeneration: Next generation acellular based tissue engineered products 3553 114548 3479 5728 PMC9343696__F2 Crosstalk between the CBM complex/NFKB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment 8915 7189 23118 PMC9355787__F1 COL1A2, AKT3 genes, and related signaling pathway in the pathology of congenital talipes equinovarus 2932 10000 2475 1278 PMC9357610__F5 Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF‐B1/Smad3 signalling pathway 4087 4088 4092 PMC9360036__F7 Proposed model of MAP4K4 and STRN3 regulation of cell migration and proliferation in MB 7408 29966 9448 27063 PMC9363121__F7 Possible model of Banp functions in stalled fork recovery, DNA damage repair, and chromosome segregation during mitosis 54971 56897 545 472 7157 80152 64151 PMC9366225__F1 CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction 102 2475 10663 PMC9367281__F4 PTEN in Epithelial–Mesenchymal Transition 4089 4088 5728 4087 6714 PMC9367289__F1 Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy 6469 6608 51684 2735 PMC9367541__F2 Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma 940 2885 3702 3932 PMC9370780__F11 Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes 7051 929 5090 627 7057 6855 2670 4280 718 347902 2634 710 PMC9376779__F3 Transcriptome changes in stages of non-alcoholic fatty liver disease 6721 22937 6720 2160 5371 3627 3091 5468 2494 7157 2309 2308 3156 3157 3479 6462 23089 PMC9377071__F7 Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease 8737 11035 197259 PMC9377691__F3 Supramolecular organizing centers at the interface of inflammation and neurodegeneration 57506 7189 115004 7187 29110 3661 PMC9379405__F7 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways 4091 4092 4089 4090 4086 PMC9381515__F1 Main detection methods of necroptosis 8737 11035 197259 PMC9388540__F6 Molecular model of FMRP-mediated regulation in GSCs 81029 1499 2932 2113 PMC9389465__F2 Glucose transporters: Important regulators of endometrial cancer therapy sensitivity 1950 51099 94031 2475 PMC9392983__F7 miR-212-3p attenuates neuroinflammation of rats with Alzheimer’s disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway 6667 23621 114548 PMC9393259__F2 Underlying pathological mechanism of ferroptosis in the development of cardiovascular disease 7099 4615 3553 PMC9395635__F1 Road testing new CAR design strategies in multiple myeloma 947 652070 940 28755 3560 PMC9400233__F5 Two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma 5775 6774 3625 4087 4088 4089 4092 29842 9314 54509 23411 PMC9404696__F7 ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition 55908 2932 1499 PMC9406051__F9 Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma 3662 3516 406947 4790 7323 817 7157 283987 PMC9410841__F11 Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice 3569 10628 114548 PMC9411277__F4 Targeting of the tumor immune microenvironment by metformin 3479 325 941 PMC9412694__F2 Impact of Epitranscriptomics on Antiviral Innate Immunity 3661 57506 3665 6007 10379 3454 6773 3455 PMC9424684__F11 Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation 4615 114548 79792 3553 PMC9424811__F4 RING finger protein family in health and disease 54778 79102 27246 115004 91445 6048 3661 29110 79589 51444 55905 PMC9425815__F4 Involvement of host microRNAs in flavivirus-induced neuropathology: An update 3925 7189 2146 406947 9655 571 PMC9433691__SF1 Compressive force regulates GSK-3B in osteoclasts contributing to alveolar bone resorption during orthodontic tooth movement in vivo 1499 324 4318 PMC9434059__F1 Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis 57154 6774 3717 4087 59 1490 1277 1278 2335 PMC9437524__F1 Neutrophil extracellular traps: New players in cancer research 3146 55246 54106 4318 1075 PMC9448717__F1 Anti-factor H antibody and its role in atypical hemolytic uremic syndrome 718 727 729 730 735 2271 PMC9449579__F1 Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy 3156 3652 2224 2222 6713 PMC9453694__F1 Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non–small cell lung cancer 1956 2932 5728 PMC9454487__F2 Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics 4089 4087 4088 9759 PMC9456027__F2 Factors and Pathways Modulating Endothelial Cell Senescence in Vascular Aging 406999 51548 23411 3486 2309 3488 3484 26291 PMC9465167__F1 Human immunodeficiency virus-1 core: The Trojan horse in virus–host interaction 920 4397 3661 29110 115004 11052 PMC9466315__F4 Immune responses to Lassa virus 29110 57506 7187 4615 7097 114609 10333 7096 324 PMC9469193__F8 Antigastric Cancer Effect of Triptolide is Associated With H19/NFKB/FLIP Axis 8717 7124 283120 PMC9476726__F11 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 54567 28514 10683 100188776 PMC9476726__F4 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 2932 1499 84133 324 PMC9476726__F6 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 5727 6469 51684 6608 2735 64399 PMC9479759__F3 Therapeutic potential of WKYMVm in diseases 2358 968 9636 7942 6778 PMC9482157__F9 VEGFA promotes the occurrence of PLA2R-associated idiopathic membranous nephropathy by angiogenesis via the PI3K/AKT signalling pathway 7422 29882 29945 10018 5371 1649 6319 PMC9485881__F3 Advances in the superhydrophilicity-modified titanium surfaces with antibacterial and pro-osteogenesis properties: A review 9332 8832 3553 7054 920 PMC9490947__F8 Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury 7097 3146 7099 PMC9492418__F6 B-Cell Translocation Gene 2 Upregulation Is Associated with Favorable Prognosis in Lung Adenocarcinoma and Prolonged Patient Survival 5705 5971 4792 4849 22864 10644 84726 PMC9494868__F7 TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NFKB signaling pathway 7153 3484 5617 PMC9496903__F7 ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism 10314 55915 23411 PMC9503946__F10 Coronaviral Inhibitors of the Nucleocapsid Protein Identified In Silico and In Vitro from a Large Natural Product Library 57506 8737 7706 1356 3576 PMC9505944__F3 Controversial Role of LPS in Platelet Activation In Vitro 4615 114609 51135 3656 3654 929 7099 PMC9510782__F6 Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein 7099 79930 4615 3717 6774 6279 PMC9511411__F5 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy 11277 25939 1314 PMC9513370__F2 Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis 941 942 940 50943 85480 3902 PMC9516113__F1 Defining and targeting patterns of T cell dysfunction in inborn errors of immunity 7535 942 941 2475 940 PMC9523169__F3 Iron dyshomeostasis and ferroptosis in Alzheimer’s disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD 8924 8031 2495 PMC9524569__F1 Protective role of ethyl pyruvate in spinal cord injury by inhibiting the high mobility group box-1/toll-like receptor4/nuclear factor-kappa B signaling pathway 3553 7124 1270 3569 7039 1950 PMC9532747__F1 MicroRNAs: Potential mediators between particulate matter 2.5 and Th17/Treg immune disorder in primary membranous nephropathy 5053 196 22925 PMC9534090__F4 Emergence and dissemination of monkeypox, an intimidating global public health problem 3661 83939 3466 6850 10379 7189 7187 920 3458 324 PMC9536090__F5 Differential modulation of cancer‐related genes by mitochondrial DNA haplogroups and the STING DNA sensing system 672 238 1956 PMC9537744__F1 Association between gene polymorphisms in the cyclophosphamide metabolism pathway with complications after haploidentical hematopoietic stem cell transplantation 1576 2944 1557 PMC9537819__F1 Dietary meat mutagens intake and cancer risk: A systematic review and meta-analysis 55023 1544 10 PMC9546849__F3 RNA m6A writer WTAP in diseases: structure, roles, and mechanisms 7490 9589 3661 3454 1950 PMC9548020__F5 Treatment effects of the EGFR pathway drugs on head and neck cancer stem cells 1950 1956 960 2885 3845 627 PMC9552026__F5 Development of degradable magnesium-based metal implants and their function in promoting bone metabolism (A review) 860 140803 54822 PMC9556862__F1 Using Clustered Regularly Interspaced Short Palindromic Repeats gene editing to induce permanent expression of fetal hemoglobin in Beta-thalassemia and sickle cell disease: A comparative meta-analysis 10661 53335 3047 3048 57862 1108 PMC9564177__F1 KEAP1-NRF2 System and Esophageal Cancer 9817 5728 2932 2729 1728 7296 PMC9564314__F5 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia 6925 1499 595 4609 4582 1956 6714 6723 PMC9564314__F7 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia 3716 6774 4582 6723 PMC9569450__F1 Dual Effect of Tryptamine on Prostate Cancer Cell Growth Regulation: A Pilot Study 130013 125061 8564 8942 23498 PMC9570382__F3 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer 728655 283120 10642 101101772 401397 2146 PMC9570443__F1 Pyroptosis and Insulin Resistance in Metabolic Organs 79792 114548 1687 PMC9572342__F9 Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor B and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA 317 7161 5728 56475 581 PMC9572342__F10 Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor B and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA 317 581 7161 56475 PMC9574103__F3 Comprehensive analysis of metabolomics and transcriptomics to reveal major metabolic pathways and potential biomarkers of human preeclampsia placenta 54575 1588 1312 1586 3283 1543 6718 1589 3292 PMC9578007__F2 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis 1803 183 7124 7099 2167 6517 3586 5328 4217 5465 5468 55671 3605 1956 2194 5950 144195 10891 3991 PMC9578007__F4 Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis 9370 7124 2194 6462 5468 2182 10891 5176 5465 3950 PMC9578543__F8 Enhanced Apoptosis in Choroidal Tissues in Lens-Induced Myopia Guinea Pigs by Activating the RASA1 Signaling Pathway 5921 572 100187761 PMC9581278__F9 Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARAlpha-SREBPs pathway 5465 1593 1581 9420 1582 8213 2264 7038 9965 PMC9583131__F3 Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice 3603 196 3553 920 PMC9584705__F8 Methylation-Mediated Silencing of RBP7 Promotes Breast Cancer Progression through PPAR and PI3K/AKT Pathway 116362 5728 7018 PMC9584741__F4 lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway 4025 5582 8209 60681 815 200958 4858 64902 339855 10060 286204 2557 123036 6262 5156 284498 128553 136259 2324 25780 PMC9586778__F4 Network Pharmacology-Based Exploration on the Intervention of Qinghao Biejia Decoction on the Inflammation-Carcinoma Transformation Process of Chronic Liver Disease via MAPK and PI3k/AKT Pathway 6774 6714 5290 3265 1956 5595 3320 2033 7422 3932 1387 387 351 PMC9589297__F5 Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects 1499 6774 3717 7040 PMC9598604__F1 Impact of an Adapted Physical Activity Program on Bone Turnover, Physical Performance and Fear of Falling in Osteoporotic Women with Vertebral Fractures: A Quasi-Experimental Pilot Study 5741 9242 3569 3553 3586 PMC9599947__F2 STAT3 Inhibitors: A Novel Insight for Anticancer Therapy of Pancreatic Cancer 6774 1956 101805492 169270 79854 PMC9601273__F1 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer 6363 1236 7422 6714 80725 PMC9601273__F4 Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer 7421 4040 4041 2932 1499 595 7052 7852 PMC9603940__F6 Microbe-Derived Antioxidants Reduce Lipopolysaccharide-Induced Inflammatory Responses by Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1B Signaling Pathway 2810 3553 114548 PMC9604716__F3 LL-37 in Bone and Periodontium Regeneration 3480 1956 2358 7099 PMC9604914__F2 Bruton’s Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis 6714 613 4067 6850 5335 973 29760 695 2475 930 PMC9606825__F2 NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia 613 4851 6868 PMC9607206__F6 Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus 51311 51284 3661 7187 3665 7098 57506 7189 3394 4615 PMC9608511__F7 Current insights into the regulation of programmed cell death by TP53 mutation in cancer 355 572 637 581 PMC9610022__F3 High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models 2475 268 1588 PMC9773994__F3 Edible plant extracellular vesicles: An emerging tool for bioactives delivery 4280 2932 5728 581 PMC9774157__F6 Maqui Berry and Ginseng Extracts Reduce Cigarette Smoke-Induced Cell Injury in a 3D Bone Co-Culture Model 9817 100187907 4318 4772 PMC9898571__F3 Osteoarthritis: pathogenic signaling pathways and therapeutic targets 2487 1499 4040 4041 860 4322 PMC9999652__F7 Exosomal cargos-mediated metabolic reprogramming in tumor microenvironment 3178 7874 5315 6495 54407 8140 246 8420 55000 302 105373869 PMC10034053__F2 Immune cells and immune cell-targeted therapy in chronic pancreatitis 3661 4599 3605 100653366 PMC10034056__F1 Effect of Bifidobacterium on osteoclasts: TNFA/NFKB inflammatory signal pathway-mediated mechanism 8717 7186 4772 PMC10034056__F2 Effect of Bifidobacterium on osteoclasts: TNFA/NFKB inflammatory signal pathway-mediated mechanism 4772 7189 100187907 PMC10038327__F4 Mitochondria as disease-relevant organelles in rheumatoid arthritis 6513 718 6510 2746 5993 9123 6774 6362 PMC1069556__F6 Effect of NS5A on the Beta-catenin signaling pathway 572 2932 1499 7008 PMC114459__F1 Mechanisms of ISG induction 7297 6772 3661 6773 PMC115962__F5 IFNG signaling pathway showing the defects in the human fibroblast mutants B3, B9, and B10 3458 3716 3717 6772 PMC1193608__F8 Model of HAV interaction with the dsRNA-induced IRF-3 activation pathway 7098 10010 29110 3661 PMC1297590__F2 Ubiquitination of key signaling in anergic T cells 942 940 83737 5091 2353 3725 4734 PMC1351030__F8 Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras 3265 1958 688 595 PMC138687__F1 The TGFB signaling pathway, showing the activation cascade and points of inhibition (??) 4091 4092 25805 1950 PMC1410736__F1 Disposition of 17Beta-estradiol (E2) and metabolites 1312 54658 6817 PMC1449730__F2 F igure 2.— 2147 729 2152 PMC1450137__F4 Proposed mechanisms underlying the control of Mesp2 expression 3516 6911 145873 100188864 PMC1525228__F9 Diagram depicting the mechanism by which NGF may inhibit GSK-3B and promote axon growth 4803 627 5728 2932 PMC1526546__F1 Innate model of lupus pathogenesis: central role of TLR-activated MZ-B cells and pDCs 5132 958 54106 940 942 PMC153558__F3 Model of the maternal Radar signaling pathway mediating early steps of dorsoventral axis formation 4086 4090 652 655 PMC1584297__F9 Cross-talk between the NFKB and the STAT3 pathways 3569 3570 6774 PMC1600679__F7 Summary of changes in the Wnt/Beta-catenin pathway in pancreatic adenocarcinoma 1499 7481 2535 2932 324 PMC16561__F6 The signaling pathway from the upstream protein-tyrosine kinases, Lyn/Syk/Btk, to cytokine gene expression through intermediate signaling proteins, PKCBI/JNK 4067 6850 695 PMC1728094__F1 The receptor for IL-6 consists of the ligand binding component (IL-6R) and the signal-transducing gp130 6774 7412 3383 PMC1751493__F2 In normal prostate epithelial cells (a), TGFB binds to the TBRI and TBRII receptors, activating the SMAD signalling pathway and inducing the transcription of IGFBP-3 and other regulatory genes 3486 3479 5266 PMC1763171__F2 The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death 7035 5091 5340 324 1431 PMC1766780__F2 Cytokine signalling and the pathogenesis of severe combined immunodeficiency (SCID) 3558 3565 59067 3600 3578 3574 3716 PMC1774101__F4 Proposed framework for recruitment of T cells into the gut mucosa by activated CD40L+ platelets 958 7412 3383 1232 1234 PMC1782267__F1 TGFB1–Smad pathway 4087 4091 4088 4089 4092 PMC1783068__F1 Proximal B-cell receptor-mediated signalling pathways 4067 2534 640 638 29760 695 2885 6850 PMC1828075__F2 Diagram showing several factors involved in lens development 655 652 6496 5629 2301 PMC1857250__F2 Tregs and rethinking cancer immunotherapy 1493 940 50943 PMC1904333__F2 Hepcidin regulation: ironing out the details 148738 3077 7036 6774 4089 57817 PMC1905729__F1 Binding of IL-12 to the IL-12RB1 and B2 chains induces phosphorylation of the kinases Tyk2 and Jak2, which associate with the cytoplasmic tails of the B1 and B2 chains, respectively 3594 3595 7297 3717 PMC1965265__F6 A schematic representation of differential testosterone action on morphoregulatory gene expression in the rat VP and LP lobes 4824 655 6469 2255 652 PMC1975829__F1 Viral infections: beneficial role of eosinophils 8288 51284 3684 PMC1993849__F7 Ischemic/hypoxic effects on cardiac myocytes and stem cells 7124 9242 6774 PMC2082128__F7 Biosynthetic pathway for the ganglio-series of glycosphingolipids 6489 8869 51046 2583 8705 6483 29906 PMC2134904__F7 Schematic representation of the effects of RhoA/ROCK signaling pathway inhibition on membrane FasL expression and lymphocytes apoptosis 387 718 355 PMC2171390__F7 Calcium-independent microtubule-dependent pathway is required for FcɛRI-mediated degranulation in mast cells 4067 2534 9846 387 100170220 PMC2215765__F1 Schematic overview of the LPS TLR4 signaling pathway 3929 929 4615 3661 7124 3553 PMC2259464__F2 TGFB signaling pathway 4087 4088 4089 PMC2265304__F1 Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs? 4087 4086 4090 4088 4089 PMC2293084__F8 PARP-1 in NFAT signaling pathway 8505 63826 4776 PMC2323197__F1 Immunosuppression in islet transplantation 3560 3558 920 PMC2364238__F1 SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer 1356 4088 4087 4092 4091 4089 7018 PMC2408406__F1 Microvasculature in the pathogenesis of inflammatory bowel disease 5091 958 7100 7099 PMC2430620__F1 Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate 2944 7040 1950 PMC2435618__F2 Pathways involved in cell differentiation, homeostasis and apoptosis in the adult intestinal epithelium, Beta-catenin and TCF4 are expressed in the proliferative compartment, where are located the intestinal epithelial stem cells 3549 6469 6925 PMC2481274__F2 Type I Interferon: Potential Therapeutic Target for Psoriasis? 3660 3433 7297 3659 6772 6773 5371 PMC2494844__F2 Genomic dissection of the cytokine-controlled STAT5 signaling network in liver 2690 9021 8835 PMC2522268__F1 Interferon-inducible antiviral effectors 3455 3460 3717 7297 PMC2561291__F5 Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions 4615 29110 7189 PMC2575629__F3 Alternative pathway of NFKB activation 4055 958 7187 5966 PMC2586335__F1 Ras signalling pathways 3725 2002 595 572 PMC2592794__F1 Monosodium urate (MSU) crystals activate monocytes via the Toll-like receptor (TLR) pathway and the inflammasome 7097 7099 929 4615 3553 PMC2628375__F7 Hypothetical scheme of activation of the murine Hamp1 promoter 148738 4086 4089 6774 PMC2634254__F4 Upstream regulators and downstream targets of Beta-catenin during embryonic liver development 2255 6425 1499 652 595 PMC2637482__F2 Crosstalk between Robo4/Slit2 and VEGF signaling pathways 9353 54538 5879 PMC2637783__F1 Toll-like receptor (TLR) signaling 7100 7096 51311 51284 54106 7097 10333 7098 7099 4118 4615 29110 3654 3661 3663 7124 PMC2639448__F1 Intrafollicular predictors and regulators of oocyte quality within the oocyte–somatic cell regulatory loop 2661 9210 4087 4088 4090 4086 5743 26585 3037 PMC2645295__F1 Airway Smooth Muscle Cell as an Inflammatory Cell 3466 7297 3716 3717 8717 7186 PMC2649302__F2 Wnt/-catenin signaling pathway 4040 2932 1499 324 PMC2658594__F4 AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration 1499 6662 4040 PMC2659383__F3 SHH signaling pathway components that have been employed in the production of genetically engineered mouse models 6469 6608 51684 4609 PMC2661541__F1 Transforming growth factor-beta (TGFB) signaling pathway 4087 4088 4089 PMC2677440__F7 Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway 374 7039 1956 7098 4586 PMC2687355__F7 The signaling pathway MyD88 ⇒ p38 ⇒ EGR-1/AP-1 is essential for GBS-induced transcriptional activation of TNF 4118 2002 1958 PMC2693146__F8 Model depicting the dual role of cGKI in BMP signalling pathway cGKI regulates BMP signalling through (light blue) modulation of BMP receptors at the cell surface and enhancement of R-Smad phosphorylation and thus Smad activation 650 4089 3397 PMC26952__F7 Activation of specific target genes by TGFB and Wnt pathways 4089 51176 4088 PMC2712666__F3 TNF superfamily: costimulation and clinical applications 939 970 7186 5266 PMC2714639__F6 MT1-MMP expression in first trimester trophoblasts is stimulated by insulin, IGF1 and IGF2 by different signalling pathways 3479 3481 3480 PMC2719943__F1 Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity 4852 181 5443 5547 4160 PMC2727282__F7 Proposed coloboma mechanism in Lrp6-null eyes and a possible signaling network during early eye development 6910 25806 652 4040 PMC2727884__F2 Mechanism of action of sorafenib 5155 7039 5159 1956 6420 7428 PMC2733795__F4 Regulation of STAT3 signal transduction pathway 6774 3570 8651 9021 10401 PMC2735600__F7 Contribution of Rho to canonical Wnt3A signaling 89780 4040 4041 2932 324 387 PMC2735864__F1 Genetic Variation in TNF and the NFKB Canonical Pathway and Risk of Non-Hodgkin Lymphoma 8717 7186 7188 8737 PMC2739756__F1 Bile acid synthesis 1593 1581 9420 1582 PMC2742089__F3 A biochemical pathway of secreted proteins that regulate D-V patterning in Xenopus 650 649 652 655 PMC2748802__F18 Hypothesized descending pathway for translating emotional states or appetitive need for food, salt or water into goal-directed motor tasks 23237 4922 6476 PMC2758611__F6 Schematic presentation of the proposed TGFB signaling alteration that promotes HNSCC in mice 4280 7046 7048 3265 4087 4088 5728 4089 PMC2774878__F2 The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis 1950 6387 7428 7852 PMC2779759__F7 Schematic model illustrating how Jun proteins regulate the TIMP-3, TACE, and TNFA pathway: Jun proteins transcriptionally activate TIMP-3 expression, which is responsible for TACE inhibition 3726 7078 7124 PMC2788512__F7 Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway 3170 6469 4010 4009 7471 5309 5015 4487 PMC2809919__F2 Epithelial–mesenchymal interactions mediated by the Sonic Hedgehog pathway in the gut 2294 2737 2736 6608 6469 PMC2810550__F2 Wnt signaling pathway involvement in cancer and neurodegeneration 4040 4041 324 1499 PMC2811741__F7 Mast Cells Mobilize Myeloid-Derived Suppressor Cells and Treg Cells in Tumor Microenvironment via IL-17 Pathway in Murine Hepatocarcinoma Model 6367 6347 4318 PMC2820658__F1 Induction of IFNs after virus infection in IFNB pretreated human DCs 7297 3716 3665 PMC2826040__F4 miR-200a is implicated in the type I interferon signaling pathway 6773 6775 3454 PMC2829627__F2 Tumor-associated angiogenesis is sustained through stromal microenvironment crosstalk 3082 3479 4282 PMC2838378__F2 Simplified schematic of the T cell receptor signaling pathway 920 3932 3702 2885 27040 PMC2840235__F1 Blockade of the VEGF pathway with mAbs 7422 7423 7424 5281 PMC2841319__F1 Pathogenesis of kidney disease in systemic lupus erythematosus 4089 1958 960 5340 PMC2849853__F5 Regulation of the Hypothalamic Thyrotropin Releasing Hormone (TRH) Neuron by Neuronal and Peripheral Inputs 4160 4852 181 23237 PMC2853973__F1 Kaposi's sarcoma-associated herpesvirus and innate immunity 29110 3661 3627 7099 PMC2858906__F1 Main steps and key regulators in blood and lymphatic vasculature development 2116 5629 54345 PMC2867239__F2 The Primary Cilium as a Hedgehog Signal Transduction Machine 6469 2736 2737 PMC2867239__F5 The Primary Cilium as a Hedgehog Signal Transduction Machine 6608 6469 6295 79659 PMC2871322__F1 Schematic of central regulation of body fluid regulation in response to acute changes in sodium and volume 4827 4922 4025 6651 551 PMC2871322__F3 Schematic diagram of the forebrain neurocircuitry and peripheral inputs underlying the influences of osmotic and peripheral angiotensin II (Ang II) on sympathetic outflow and the baroreflex 6651 551 4025 4827 4922 PMC2874080__F2 Pathway of de novo synthesis of saturated and monounsaturated fatty acids and regulation of lipogenic genes by transcription factors (LXR, SREBP-1c and ChREBP) 2539 5226 355 79071 6319 PMC2874622__F2 The Role Of Mitochondria In The Mammalian Antiviral Defense System 9927 79671 57506 7385 PMC2880522__F1 Results of a Pathway Studio® analysis of direct relationships between the components of the protein-bound fraction of renal cyst fluid 3858 3848 462 5265 213 2161 335 5340 197 718 350 2243 PMC2886162__F5 SIRT1-dependent Regulation of Chromatin and Transcription: Linking NAD+ Metabolism and Signaling to the Control of Cellular Functions 10135 64802 10117 23411 7018 PMC2890409__F1 Classification of Dengue Fever Patients Based on Gene Expression Data Using Support Vector Machines 23586 51284 4615 3665 54106 7098 3661 PMC2893682__F7 Interaction scheme of Shh and activated Beta-catenin signaling 6469 6608 1499 4853 PMC2898451__F8 Schematic illustration of signaling pathways involved in PDGF-mediated induction of Arc expression 5159 1958 23237 PMC2901795__F1 Left: the EGFR pathway; Right: inhibition of the EGFR pathway by the EGFR monoclonal antibodies 7039 1950 1956 3845 PMC2909029__F2 A possible mechanism for the inhibitory effect of p66Shc on mitogenic signaling 1950 1956 2885 PMC2910246__F8 Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: Apoptosis through the formation of 3-hydroxykynurenine 3717 3716 6772 PMC2911501__F2 gp130-dependent cytokines promote axon regeneration and SOCS3 act as a critical negative regulator of the signaling pathway 1270 3976 3569 3667 3717 6774 9021 PMC2915738__F7 Metalloproteinase-dependent cross-talk between the PDGFRB and the EGFR/ERK1/2 signaling pathway 6868 1956 5155 5159 PMC2918404__F8 Osteogenic Transcription Factor Runx2 Regulates Components of the Fibroblast Growth Factor/Proteoglycan Signaling Axis in Osteoblasts 2247 2260 860 PMC2921612__F1 Molecular Diagnosis and Therapy of Kidney Cancer 7428 2475 7039 1956 PMC2925029__F3 The IFN-λ receptor signaling pathway 56832 7297 3716 3717 6772 6773 4599 3454 3455 PMC2939392__F2 Proposed inhibitory mechanisms of SOCS1 on TLR signaling 7099 114609 4118 8651 4615 3661 PMC2943748__F6 SENP1 participates in the dynamic regulation of Elk-1 SUMOylation 3066 2002 2353 29843 PMC2945668__F1 TLR7/9 Signaling pathway leading to the production of proinflammatory cytokines and type I IFN 54106 51284 4615 3654 51135 7189 3663 3665 PMC2947835__F2 Membrane proximal intracellular signals at the IS versus the HIV VS 3932 5335 2885 27040 920 PMC2953155__F5 Model schematic of Nipah virus-triggered DC immune response mechanisms and antagonist activity of the response 7297 3716 3665 6351 PMC2962793__F2 Cytochrome P450 epoxygenase expression in tumor cell compartments and their potential role in cell–cell communication in the tumor stroma 1573 1558 1559 2247 PMC2981460__F1 TGFB canonical signal transduction pathway and transcriptional responses mediating TGFB growth inhibitory effects 4087 4088 4089 993 PMC2991085__F2 Stress-Activated Cap’n’collar Transcription Factors in Aging and Human Disease 9817 4094 571 PMC3009535__F3 Functional module of the CXC chemokine pathway uniquely identified by NeMo 2768 50487 5320 64600 8399 8398 30814 5322 26279 5321 5578 10672 5580 2767 PMC3010754__F1 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors 1555 1548 1544 1559 PMC3025702__F2 Combination Treatment with Progesterone and Vitamin D Hormone May Be More Effective than Monotherapy for Nervous System Injury and Disease 4803 627 572 PMC3027599__F6 Ingenuity Pathway Analysis Network 2 depicting relationship among up-regulation Genes in SL1344 vs SB1117 infection groups at 8 hours 171177 23092 388 PMC3042782__F2 Models for HJV cleavage by furin-like activity and matriptase-2 5045 654 148738 PMC3048459__F3 TGFB Smad-dependent signaling pathway: TGFB exerts its effect by binding and activating type II receptor (TGFBR2) and then type I receptor (TGFBR1) 7046 64750 57154 7018 PMC3060878__F5 FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways 9965 26291 1593 9420 1581 152831 2264 1582 PMC3064629__F6 miR-34a, MAGE-A genes, and p53 form a positive feedback loop modulating chemosensitivity in cancer cells 4101 4111 4102 4105 PMC3073074__F1 The pathway of propionyl-CoA to succinyl-CoA metabolism is displayed 5095 5096 84693 166785 326625 PMC3074148__F5 Schematic representation of the two degradation pathways followed by MicA 100507436 6036 6037 PMC3074487__F8 Migration of FGF7-stimulated epithelial cells and VEGF-A-stimulated HUVECs depends on EGFR transactivation by ADAM17 1956 1950 1839 6868 6714 PMC3095763__F1 Toll-like receptor Signaling in Neural Plasticity and Disease 7099 929 4615 3661 6773 6772 1958 4318 PMC3099575__F5 Model of relationship among Hfe, Tmprss6, and the Bmp/Smad signaling pathway in hepcidin regulation 654 148738 164656 3077 57817 3397 4092 PMC3103347__F7 Schematic diagram for the SCGB3A2-induced inhibition of the TGFB signaling pathway 117156 3458 6772 4087 4092 PMC3104579__F1 RhoA/ROCK I pathway and remodeling of microtubule network underlie the polarization and migration of HSPCs 947 7852 960 3383 9242 3385 387 PMC3111669__F2 BMP signaling and its blocking 4086 4090 4089 4091 PMC3129465__F2 Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies 2312 85480 134430 10344 7040 PMC3130491__F4 Schematic of leptin intracellular signaling through the STAT3 and PI3K-PDE3B-cAMP pathways in the hypothalamus 9021 3717 3667 6774 5140 4852 5443 PMC3131053__F1 Differential involvement of IKKB/NFKB signaling in neurons of the hypothalamic arcuate nucleus in the pathogenesis of obesity and hypertension 4852 181 5443 PMC3134994__F1 Schematic Illustration: TGF-beta signaling pathway 4087 4089 4092 PMC3147552__F8 Schematic overview of IDO induction by H 7099 3716 7297 4615 6773 6772 10379 3661 PMC3158097__F1 Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy 1499 324 2932 PMC3163574__F2 Identification and Visualization of CD8+ T Cell Mediated IFNG Signaling in Target Cells during an Antiviral Immune Response in the Brain 3458 3460 3459 3716 3717 6772 PMC3169542__F7 Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD 7098 57506 3661 PMC3169577__F1 Evolution of the TGFB Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi 4087 4088 4090 4086 4091 4092 4089 PMC3179812__F6 Stem Cell Marker (Nanog) and Stat-3 Signaling Promote MicroRNA-21 Expression and Chemoresistance in Hyaluronan/CD44-activated Head and Neck Squamous Cell Carcinoma Cells 960 6774 79923 27250 331 PMC3185015__F9 RSPO1/Beta-Catenin Signaling Pathway Regulates Oogonia Differentiation and Entry into Meiosis in the Mouse Fetal Ovary 284654 1499 2254 339345 PMC3185810__F1 Interplay between HTLV-1 and the type-I interferon (IFN-I) induction pathway 7098 51311 54106 51284 4615 7189 7187 3665 3661 PMC3186011__F1 Cell surface and endosomal recognition of viruses by Toll-like receptors (TLRs) 7097 7099 7098 51284 54106 7189 7187 8195 3661 3663 3552 3569 3553 PMC3191937__F3 Local regulatory proteins that mediate some of the actions of TGFB in human myometrium and leiomyoma 1490 861 860 PMC3193406__F3 NIK stabilization as a mechanism of non-canonical NFKB signaling 7186 7187 80829 PMC3193487__F1 Schematic of crosstalk between TLR pathway and MHC molecules 7099 4615 695 958 3661 7098 PMC3193496__F4 Context-dependent function of HIPK2 in Wnt signaling 28996 6929 51176 PMC3209384__F8 Schematic showing the mechanism(s) of activation of the NLRP3 inflammasome and NFKB signaling pathways by vMyxM013-KO virus infection in human monocytic cell line THP-1 3553 7124 114548 PMC3210456__F7 Cyclin D1 action and degradation 2932 595 9099 PMC3223252__F7 A refined model shows MEHP-decreased TIMP2 expression in Sertoli cells is mediated by the inactivation of CEBPA and the activation of MYC and is dependent upon the FSH-stimulated cAMP signaling pathway 2492 4313 7077 1050 4609 PMC3224437__F4 Fatty acid biosynthesis model and pathway distance calculation method 9415 355 3992 6319 5091 PMC3233625__F3 Pleiotropic functions of EAPII/TTRAP/TDP2 958 4087 4088 PMC3234318__F1 OB inhibition by MM cells 3574 3562 6348 3082 650 246778 PMC3234335__F1 Hereditary Hemochromatosis and Transferrin Receptor 2 7018 654 3569 3077 3570 7036 6774 4089 4090 4086 57817 PMC3234798__F9 miR-26a pathway in the initiation of ASMC hypertrophy 1958 10106 7054 2932 PMC3235520__F1 Proposed model of the type I interferon induction by HIV-1 and HIV-1-infected cells 920 5132 54106 51284 7852 4615 3661 PMC3248191__F7 Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors 2919 6374 3875 9965 1326 2171 7127 64332 3162 PMC3248879__F4 In silico analysis and gene expression studies suggests functional coupling between FTO and the BDNF/NTRK2-signalling pathway 627 1051 79068 1958 1959 2353 PMC3253704__F1 Prominent signaling pathways involved with PDAC tumoral compartment and stromal compartment crosstalk 3845 6608 6469 PMC3262611__F1 Folic acid metabolism 1719 4397 4524 1786 1788 PMC3285584__F9 Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway 2737 2253 4087 2290 4838 6469 PMC3317170__F1 The activation of TLR2 by Leishmania sp., leading to a proinflammatory (left), or anti-inflammatory arm (centre and right) 7097 4615 9021 7054 7099 PMC3317440__F2 Strain-specific host gene networks activated in Mtb-infected BMM 3594 6774 1950 1839 1154 6776 2185 3065 1236 3676 134429 50814 595 5465 221895 5468 51102 PMC3319521__F1 The CD47-SIRPA Pathway in Cancer Immune Evasion and Potential Therapeutic Implications 140885 961 920 PMC3340168__F13 Apoptotic and necrotic targets modulate viability of epithelial responder cells by eliciting multiple recognition-dependent signaling pathways 572 2932 1499 595 PMC3340256__F1 tBID structure and mechanism of action 637 7124 23788 PMC3356999__F1 Fatty acid regulation of hepatic lipid metabolism 9415 3992 2194 79071 54898 60481 6319 PMC3366440__F1 Protective and pathogenic functions of Th17 cells 59067 4049 112744 3605 50943 6774 920 PMC3367558__F3 Negative regulation of AChR clustering by Wnt3a 89780 1499 2932 PMC3372896__F1 Central role of Beta-catenin in Wnt signaling and the cadherin complex 1499 4040 4041 2932 324 7008 PMC3382229__F5 Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis 1671 1668 1667 1670 4316 1669 PMC3387006__F7 miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes 10468 4088 7048 3400 1634 5516 7057 7046 7042 4052 1875 9475 PMC3392816__F5 Model for inhibitory effect of extracellular nicotinamide phosphoribosyltransferase on insulin-like growth factor-1 function in chondrocytes 3480 3667 3479 PMC3405133__F3 Identification of Pathway Deregulation – Gene Expression Based Analysis of Consistent Signal Transduction 6932 83439 6934 4609 51176 595 3725 2353 PMC3406577__F6 Restoration of cell death by ABT-737 in cancer cells that overexpress Bcl-2 and caspase activity is blocked 637 331 27429 PMC3407218__F5 CXCL12/CXCR4 Axis Triggers the Activation of EGF Receptor and ERK Signaling Pathway in CsA-Induced Proliferation of Human Trophoblast Cells 6387 7852 1950 1956 6714 4313 PMC3407530__F5 A simplified model for p80HT targeting the IL-10-Stat3 signaling pathway to promote plasma cell expansion and tumor development 595 894 6774 7297 3716 PMC3410851__F9 Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System 6910 7472 7482 9496 10253 2263 2255 652 6662 PMC3413998__F6 Canonical Wnt signaling pathway 4041 4040 324 1499 2932 22881 26281 4609 PMC3418323__F2 Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor 3976 3716 6774 PMC3427140__F4 Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function 2932 324 9314 1499 PMC3427656__F1 GH-STAT5 signaling pathway 2690 3479 1030 1026 PMC3429771__F5 Opposing roles of FGF2 and BMP4 in directing TB formation from epiblast type ES cells and iPS cells and the need to exclude FGF2 from the growth medium to minimize the co-induction of mesoderm and endoderm 2247 652 650 655 3135 PMC3432272__F1 HIV’s double strike at the brain 920 7852 1234 PMC3434202__F1 Suppression of Cancer Progression by MGAT1 shRNA Knockdown 4245 4247 4249 PMC3436188__F8 Interaction between Ryk and Wnt signaling pathways 1499 6259 57216 4040 4041 387 PMC3436227__F2 MyD-88 dependent TLR signaling pathway 7096 51284 54106 7097 7099 10333 51135 3654 7189 3661 4615 PMC3444148__F1 Nodal signaling pathway in melanoma 4838 4855 145258 4089 PMC3447932__F10 Vsx2 Controls Eye Organogenesis and Retinal Progenitor Identity Via Homeodomain and Non-Homeodomain Residues Required for High Affinity DNA Binding 4286 338917 5013 PMC3464089__F2 Aberrant activation of the MAPK signaling pathway in papillary thyroid tumor cells 5979 4914 673 PMC3464365__F1 Linking cellular metabolism with the circadian clock transcriptional complex 23411 406 9575 10135 9611 8841 2146 PMC3474235__F1 The prostaglandin biosynthetic pathway (adapted from ) 15-deoxyΔ12-14-PGJ2 is a metabolite derived from arachidonic acid 5226 2938 2944 PMC3478592__F1 Model depicts the development of conventional vs 3566 3662 8320 3702 PMC3488313__F4 Proposed mechanism of associated vWF activating GPIIb/IIIA 7450 5336 5908 PMC3490280__F2 Recipient T-lymphocytes govern Mesenchymal stem cell (MSC)-based bone regeneration via IFNG and TNFA 355 4091 860 9242 PMC3491533__F8 Diagrammatic presentation shows how Notch and TGFB signaling pathway involved at each pathogenic stage of HBV infection 920 619501 50943 PMC3492913__F1 Diagrammatic representation of BMP signaling pathway 659 657 4090 4086 PMC3493824__F1 Cellular Targeting in Autoimmunity 3383 914 920 940 PMC3498346__F1 Impaired Skeletal Muscle Regeneration in the Absence of Fibrosis during Hibernation in 13-Lined Ground Squirrels 5081 4618 4617 PMC3504253__F1 Inactivated Wnt pathway 324 4040 4041 PMC3504728__F7 Speculative model of macrophage alternative activation regulation by estrogen 3716 6778 8651 PMC3520610__F1 Targeting the TGFB signalling pathway in disease 4088 4092 4087 4089 6497 29102 PMC3520610__F5 Targeting the TGFB signalling pathway in disease 4088 4087 4089 7018 PMC3529366__F6 BMP2-WNT4-FOXO1 pathway in HESC differentiation 650 4090 4086 54361 1499 2308 6750 7044 10018 1634 PMC3529674__F5 MyD88-independent TLR signaling 7099 29110 3661 PMC3534992__F7 MiR-146b function in IEC-6 cells mediating TGFB signaling 4089 4087 4088 6478 4092 PMC3536347__F1 Pharmacologic inhibitors of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) 8324 8325 6424 4040 4041 8658 2932 1499 324 PMC3536698__F8 IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling 7098 51284 4615 3654 7189 3663 57506 29110 3661 3627 91543 3434 PMC3538421__F3 Summary of P450 enzymes in cholesterol and bile acid biosynthesis 1595 1593 1581 10858 1576 1582 9420 51302 PMC3539261__F2 Initiation of the inflammatory response to monosodium urate crystals (MSU) by the innate immune system 114548 51135 3553 PMC3549669__F6 STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway 51428 3428 3661 29110 PMC3561537__F6 Scheme of EGFR signaling pathway activated by NEU3-induced GM3 reduction 10825 1950 1956 PMC3561559__F9 Schematic model of autoregulation of BMI1 1499 648 324 PMC3562627__F2 EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer 1956 3845 673 PMC3565434__F8 Schematic diagram of proposed CD44-regulated signaling pathway 960 3932 2534 PMC3574816__F1 Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention 1499 2932 324 PMC3575670__F5 Precursor of myostatin is promyostatin and consists of a propeptide that binds to myostatin noncovalently to form an inactive complex 4087 4088 4089 PMC3582304__F1 Diagrammatic representation of the canonical Wnt signaling pathway 4040 4041 2932 324 1499 PMC3582304__F2 Therapeutic targets of the Wnt signaling pathway 4040 4041 324 2932 1499 PMC3584867__F9 The multiple functions of PE 5340 727 729 735 PMC3586206__F1 Schematic summarizing the effects of MIF on the canonical MAPK pathways 4282 7852 972 PMC3587725__F1 Regulation of AMP gene expression through the VDR or FXR pathways 4615 64127 3554 PMC3590592__F6 Proposed schematic representation of Wnt5a/Beta-catenin signaling in keloid pathogenesis 7474 324 2932 1499 PMC3602516__F1 Identification of Small Molecule Activators of BMP Signaling 650 4090 4086 4091 4092 4089 3397 PMC3612034__F3 Identifying Resistance Mechanisms against Five Tyrosine Kinase Inhibitors Targeting the ERBB/RAS Pathway in 45 Cancer Cell Lines 928 4072 3964 PMC3614511__F8 Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGFB–TAK1–Dependent Mechanism 51564 4208 4319 PMC3620567__F1 Ischemia-reperfusion injury in the diabetic myocardium is multi-factorial and complex 5728 572 3717 PMC3621569__F3 Inversin functions as a switch between the canonical Wnt and non-canonical Wnt/PCP pathways 4040 4041 57216 387 2932 1499 324 PMC3621754__F5 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches 1956 6714 1499 595 6934 PMC3622708__F8 Wnt3a/Beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling program 4851 84667 343930 3955 PMC3631444__F6 The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells 6770 1583 1586 3293 10170 PMC3636710__F9 LBP/CD14-independent activation of host cells by E·albumin 3929 929 7099 PMC3637970__F1 Transforming growth factorB (TGFB) signaling pathway 4091 4092 4087 4088 4089 3397 7018 PMC3648641__F1 Unraveling Mechanisms Regulating Systemic Iron Homeostasis 164656 148738 654 3077 7036 4089 PMC3657461__F1 Androgen receptor (AR) signaling in prostate cancer 367 1950 5728 6774 PMC3657461__F6 TGFB/SMAD signaling pathway and its implication in prostate cancer 27302 4092 4087 4088 367 4089 PMC3657461__F7 Wnt signaling and its implications in the development of prostate cancer 4040 4041 2932 1499 4609 324 367 PMC3660063__F2 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response 1956 1950 2885 1848 1847 PMC3660156__F4 Tumour dormancy and clinical implications in breast cancer 5340 1950 1956 PMC3662904__F1 Transforming growth factor (TGF)B signaling cascade 4092 4087 4088 57154 4089 6497 PMC3667241__F1 Schematic drawings of the neuronal signaling pathways of anorexigenic and anxiogenic-like action in goldfish 885 10874 1392 2797 PMC3668182__F2 Specification of GABAergic Cortical Interneurons 6469 6750 26468 55553 431707 1746 1745 170302 1749 1750 170825 219409 4852 PMC3670000__F3 Signaling pathways activated by E2 and its crosstalk with GH 2690 3717 8835 PMC3670242__F1 JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspective 3717 204 6774 PMC3670266__F1 Circulating miRNAs as new activators of the JAK-STAT3 pathway 9655 3569 6774 PMC3672788__F6 Summary for the effect of calcineurin inhibitor, tacrolimus, on the regulation of RANKL expression through IL-6/sIL-6R/JAK2/STAT3/SOCS3 pathway 3717 9021 6774 PMC3672943__F1 Integration of Cell Signalling Pathways into Higher Order Networks Sculpts Transcriptional Landscapes 1499 860 6910 8928 PMC3676171__F2 Bile acid synthesis, conjugation, and biotransformation 1593 9420 570 1576 PMC3677627__F5 Molecular network based on some key metabolites reversed by resina draconis or isosorbide dinitrate treatment 50940 80310 117579 2863 9340 10268 2868 114131 PMC3684282__F10 Schematic of myelin-mediated activation of the TGFB signaling pathway and downregulation of Smad2 by SLPI 7046 7049 4087 6590 PMC3687624__F1 Simplified view of the canonical Wnt signaling pathway (Modified from ref 50964 2932 324 4040 4041 PMC3690105__F1 Metabolic pathway of clopidogrel 1555 1557 1559 PMC3693006__F4 Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells 7099 4615 7189 27250 114609 4118 PMC3694614__F9 Free Radical-Producing Myeloid-Derived Regulatory Cells: Potent Activators and Suppressors of Lung Inflammation and Airway Hyperresponsiveness 3586 6367 941 PMC3703119__F5 Schematic representation of the pathogenetic mechanism of AD copper phenotype 540 475 150684 PMC3705329__F1 SMAD/BMP pathway in hepatocytes 4089 101241900 7036 3077 7018 PMC3708280__F1 A simplified scheme of signaling pathways and cellular events involved in embryonic skeletal muscle formation 652 89780 7471 7476 6469 PMC3710321__F1 Regulation of STATs by polycystin-1 and their role in polycystic kidney disease 3717 3082 6772 6774 1950 6714 6778 3565 3596 PMC3712028__F7 Model for the mechanism of regulation of glucose metabolism in muscle and liver by leptin in the VMH 6774 5443 23237 PMC3714205__F2 Signaling via by cytokines and growth factors and its negative regulation by SOCS proteins 112597 9021 8651 122809 9655 8835 30837 PMC3722447__F1 Defects within components of the ECM and the TGFB signaling pathway leading to various HCTD 7048 7046 4087 4089 7018 PMC3722958__F2 The suggested interplay between natural killer (NK), CD4+ T, B cells, and polymorphonuclear cells (PMN) during pemphigus pathogenesis 9261 7867 920 1830 PMC3731217__F7 Cited1 Deficiency Suppresses Intestinal Tumorigenesis 324 4435 1499 PMC3731598__F1 An immune synapse and downstream events 3902 151888 1493 940 958 970 939 PMC3732476__F2 Notch signaling pathway 102 6868 9794 PMC3734934__F6 Disruption of mindin exacerbates cardiac hypertrophy and fibrosis 4280 4089 4087 4088 PMC3735683__F3 From Genetics of Inflammatory Bowel Disease Towards Mechanistic Insights 50506 4688 4689 PMC3740690__F1 Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22 204 5771 50943 PMC3742224__F3 Structure of human cine-N-methyltransferase (GNMT) gene in connection with scheme of sarcosine genesis in biochemical pathway 27232 29958 1757 PMC3754482__F6 Glycocode model: 3-OST-5 and 3-OST-6 regulate distinct cell signaling pathways for ciliogenesis and cilia motility 2253 2260 9371 5990 PMC3755284__F1 Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization 594857 4810 729 3598 2597 PMC3757404__F1 Wnt/Beta-catenin Signaling Pathway 50964 4040 4041 1499 324 PMC3759014__F1 The main constituents of the Sonic Hedgehog (SHH) pathway include the SHH ligand and the transmembrane proteins PTCH1 and SMO 5727 6608 6469 PMC3762983__F2 Example of a pathway reconstruction experiment 653 9210 27302 4089 4088 7048 4087 PMC3763461__F1 Hypothetical model explaining the pathway through which mutated htt (mhtt) causes OMM permeabilization 627 572 637 664 4976 PMC3763909__F2 The role of androgens/AR in acne formation/progression 2308 3479 367 PMC3765909__F2 Mechanism of blockade of the Wnt signalling pathway by osteocytes 4040 4041 56955 PMC3773516__F6 MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways 1746 1745 170302 4208 10716 6660 9839 4204 1385 406921 2332 PMC3782845__F5 MYD88—an intriguing link between WM and natural effector IgM+ memory cells 7099 7097 51311 54106 7100 51284 114609 4615 51135 3654 7189 939 PMC3792737__F9 Summary of the interactions identified in this work between Dmrt5 and the secreted ligands and Wnt/Bmp regulated graded transcription factors expressed during early patterning of the cerebral cortex 2737 5080 2018 9355 23316 4781 PMC3798191__F5 The relationships between the RA, FGF and Notch pathway in Xenopus PSM 3516 10658 1848 2253 PMC3807052__F1 Migration of opioid-containing immune cells and opioid release within inflamed tissue 3383 3576 3553 PMC3807853__F9 IL-33 markedly activates murine eosinophils by an NFKB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop 6361 22797 6778 90865 2920 3627 26253 136 PMC3810304__F1 Potential pathways by which CKD modulates the accumulation of arterial macrophages 7412 3383 6347 1236 PMC3812980__F6 Proposed schema of how the BMP signaling axis limits neurogenic muscle wasting 4089 4090 4086 658 PMC3817731__F3 Activation of the EGFR pathway and the consequent engagement of the Ras/Raf/MAPK and PI3K/Akt pathways 1950 1956 2885 PMC3819657__F3 Combined miRNA/mRNA regulatory and functional enrichment network 2069 1295 409 10800 9021 5054 861 5293 129607 5292 PMC3821554__F1 The TGFB signaling pathway is regulated at multiple points by ubiquitin-mediated targeting and proteasomal degradation 4092 4088 4089 PMC3822826__F2 Canonical Wnt/Beta-catenin signalling pathway 7471 2932 324 1499 6925 PMC3823708__F9 NFKB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma 3717 3716 9021 3976 6774 PMC3824536__F1 Druggable Drivers of Lung Cancer 2264 3845 57144 4293 PMC3826168__F2 Molecular mechanism and function of CD40/CD40L engagement in the immune system 958 7186 7187 PMC3831179__F15 Pathway Commons (accessed through Cytoscape) 6497 4090 4088 4092 4086 4089 4091 4087 PMC3836826__F3 Stress-response pathways are altered in the hippocampus of chronic alcoholics 7099 10628 3553 3569 PMC3837055__F1 Schematic view of kallistatin action in the canonical Wnt pathway 4040 4041 2932 324 1499 PMC3847901__F2 Rat sarcoma viral oncogene homolog (RAS) activation converts normal keratinocytes to an initiated phenotype through a series of potentially reversible autocrine signals 1956 1950 2534 6714 4615 6372 2920 2919 3579 4318 PMC3867867__F3 Genetic determination of testes in Japanese medaka fish, chicken, and mouse 668 399823 1588 6736 1761 7490 6662 2254 268 54361 PMC3870610__F8 Signaling pathway of the AMH protein 268 269 4089 4090 4086 PMC3874163__F8 A simplified view of siRNA-enhanced DNA-mediated IFN-λ1 signalling pathway 3428 57506 29110 3661 PMC3876437__F1 A non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis 3717 3459 3460 3716 PMC3877388__F6 Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling 3570 6364 4040 6774 100133941 920 PMC3886801__F1 STAT-3: A Molecular Hub for Signaling Pathways in Gliomas 1950 6774 6714 7273 10401 PMC3887453__F2 Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress 50507 27035 100271849 3726 PMC3888285__F2 Liver responds to iron signals to regulate hepcidin production 148738 654 3077 7036 4090 4086 4089 3397 4092 PMC3889251__F9 New proposed model of BMP2-induced C2C12 cells differentiation 650 4089 2475 PMC3896749__F9 Hypothesis for the development of tactile allodynia following nerve injury 7099 7097 114609 3661 4615 7124 PMC3896784__F8 Model of FTO regulation of leptin action and glucose homeostasis through the LepRb-STAT3 signaling pathway 3717 6774 3953 9021 79068 PMC3900493__F2 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms 4049 4055 4050 958 643 29851 920 PMC3900493__F3 Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms 4055 4049 4050 PMC3904630__F9 OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness 4760 6096 5015 1406 4901 10002 PMC3910345__F3 Molecular regulation of hepcidin by iron and inflammation 3569 654 7036 3077 148738 3570 4086 4090 6774 4089 PMC3916405__F1 Distinct Antiviral Responses in Pluripotent versus Differentiated Cells 6041 6035 57506 7098 PMC3917351__F4 Ca2+ transport remodelling in tumour vascularization 7223 7222 7225 140803 7226 54822 51393 59341 PMC3920008__F4 Novel regulatory pathway of intracellular lipid homeostasis 1593 355 1582 PMC3922885__F7 RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3 389 6774 79923 PMC3926427__F4a Targeting Fibroblast Growth Factor Pathways in Prostate Cancer 2247 2255 2260 2254 2253 PMC3928173__F4 Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis 9271 55124 143689 56165 PMC3928694__F2 TLR signalling pathways: TLRs signal through myeloid differentiation primary response gene 88 (MyD88) or/and TIR-domain-containing adapter-inducing interferonB (TRIF)-dependent pathways 7098 54106 51284 7096 10333 7097 7099 4615 114609 7187 7189 3661 PMC3930409__F10 Epidermal growth factor (EGF-EGFR) signalling pathway in hepatocellular carcinoma (HCC) inflammatory microenvironment 1950 6374 3576 3579 1956 PMC3936609__F7 Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment 7040 7049 4087 4088 4089 PMC3937760__F4 miR-182 plays an important role in CEBPA/miR-122/IGF1R pathway 1050 3480 2932 595 PMC3940310__F2 Pathways for hepatic fatty acid synthesis (FASN) 60481 9415 2194 3992 79071 54898 6319 PMC3942790__F2 Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches 654 3077 148738 164656 PMC3942790__F3 Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches 654 3077 148738 PMC3943178__F3 Coordination of macrophage-mediated signaling and muscle regeneration 7124 3458 4087 4088 9314 PMC3944819__F7 Schematic of ANDV N and GnGc protein regulation of TBK1 signaling 57506 7187 29110 3661 PMC3947766__F1 Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time 54106 51284 81622 PMC3960235__F3 The Anti-Hypercholesterolemic Effect of Low p53 Expression Protects Vascular Endothelial Function in Mice 1581 4280 140805 PMC3967171__F2 Sex hormones and SREBP selectively regulate expression of Aldh1 220 8854 216 PMC3969997__F7 The hypothetical signaling pathway in pathological angiogenesis regulated by interactions of activated VEGFR2 and EPOR 7422 2057 6774 PMC3972890__F6 CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis 50616 6387 7852 9021 6774 PMC3975104__F2 A simplified model of some of the signaling pathways leading to LTD of the pf-PC synapse 2638 5091 3479 3480 PMC3989450__F2 Canonical Wnt signalling 4040 4041 324 1499 2932 PMC3989668__F3 Ubiquitylation maintains the equilibrium between differentiation and transformation in adult stem cells 4092 64750 1499 54894 55294 84133 83737 324 PMC3996160__F6 A hypothetical model depicting the mechanisms used by SARS-CoV PLpro-TM to disrupt the STING-TRAF3-TBK1 complex required for activation of the IFNB production pathway 57506 7187 29110 3661 PMC4002088__F7 Schematic representation of the proposed novel TXNIP/miR-124a/FOXA2/IAPP signaling pathway 10628 3170 3375 PMC4002809__F2 Current model for NFKB signaling pathway induced by C-type lectin receptors 79595 6850 5336 64170 8915 PMC4007596__F3 Cytoscape plugin was used to analyse within C57Bl/6 up-regulated genes, genes interaction within the same pathway and across different pathways 4717 3028 2475 PMC4013140__F7 The Repressive Effect of miR-148a on TGF beta-SMADs Signal Pathway Is Involved in the Glabridin-Induced Inhibition of the Cancer Stem Cells-Like Properties in Hepatocellular Carcinoma Cells 4087 4088 4089 PMC4017430__F1 Leptin receptor signaling 3717 9021 6774 PMC4033628__F3 Representative core M3 structures that are dependent on multiple initial activities based in the ER 10585 29954 84892 148789 84197 120071 PMC4036353__F8 How TAZ/YAP direct TGFBeta-induced tumorigenic events 4087 4088 4089 652995 257194 PMC4036354__F1 Cross-talk between Two Signaling Pathways Drives Aggressive Late-stage Breast Cancer♦ 4087 4088 4089 257194 652995 PMC4038158__F3 Signaling pathway initiated by Edn1-induced Ednra signaling 4853 1909 23462 7474 64388 10672 2767 2776 5332 5331 4208 1750 1969 1906 9464 9421 145258 PMC4039567__F8 De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways 7099 7097 4615 6347 2919 2920 1431 PMC4043860__F2 Transcriptional control of spermatogonial maintenance and differentiation 2668 2247 2674 5979 5453 3400 2119 2308 5460 3975 255877 PMC4045235__F3 CUL7-OBSL1-CCDC8 pathway and its predicted role in cell growth 3667 3643 83987 23363 9820 PMC4052696__F9 Pathway Bridge Based Multiobjective Optimization Approach for Lurking Pathway Prediction 132299 367 4087 4088 4089 4092 PMC4057583__F10 Link between NFKBIA and EGFR pathway in Glioblastoma 1950 1956 4792 PMC4064057__F3 Genotype-specific steatogenic pathways associated with hepatitis C virus infection 9021 355 5728 PMC4066644__F2 Model of tumor heterogeneity 6469 5727 6608 PMC4070857__F2 The primary mechanisms through which vitamin D-regulated dendritic cells (DCs) and T-lymphocyte function.Notes: vitamin D precursors can be further processed to their active metabolite, 1,25(OH)2D3, in DCs and T lymphocytes 1594 3458 7421 6367 941 942 958 PMC4077896__F1 Autophagic structures in the regulation of MAPK phosphorylation 23192 5894 1950 PMC4087507__F1 NOD2/TLR4 signaling pathway 64127 4615 7189 7099 PMC4089092__F1 Toll-like receptor (TLR) signaling pathway 7099 929 4615 7189 PMC4090903__F2 TLR4 intracellular signaling cascade 7099 929 114609 51135 4615 3654 3627 PMC4100108__F4 The possible regulatory pathway of melanogesis activation 1499 22943 4286 434 4157 PMC4105632__F1 Nigrostriatal, mesocortical, and mesolimbic pathways 6750 7054 2821 PMC4107945__F1 RLR signaling pathway is shown 7706 27005 57506 3661 29110 PMC4111284__F1 IGF signaling pathway 6750 2691 2692 3482 2690 3483 3479 3481 3480 PMC4112617__F1 Insulin-like growth factor pathway 3481 3479 3480 3482 PMC4118128__F9 The proposed model for the regulation of the IRS-1-PI3K-mTOR pathway by PRCP and PREP 5547 5550 3667 2475 PMC4127235__F1 Wnt/Beta-catenin pathway 4040 4041 1499 324 PMC4127235__F2 Beta-Catenin is an antagonist of the NFKB pathway 4040 4041 1499 PMC4129668__F1 Roles of PGs/GAGs on the breast cancer motile phenotype 7474 6714 1956 PMC4131434__F4 The enemy within: endogenous retroelements and autoimmune disease 115004 3428 29110 3661 PMC4134798__F1 Mechanism of bone resorption in bone marrow metastasis 7852 6387 4018 7412 3479 PMC4137222__F2 HBV interaction with the ER-associated degradation pathway 9695 80267 55741 PMC4141540__F7 Schematic model of WNT7B signaling in CRPC cells and osteoblasts 7477 367 4082 PMC4145906__F3 The role of mitochondria in Parkinson's disease 120892 5428 7019 PMC4146704__F6 MIF-CD74-Lyn signaling cascade during osteoclastogenesis 4282 972 960 4067 6850 9846 4772 PMC4150760__F3 Inferred non-small cell lung cancer pathway using the SpliceNet and RNASeqNet 7039 1950 2064 1956 2885 673 572 PMC4151823__F9 WWOX At The Crossroads Of Cancer, Metabolic Syndrome Related Traits And CNS Pathologies 4092 23327 4088 64750 57154 51741 4089 860 PMC4152115__F5 Plausible molecular mechanism of migration and osteogenic differentiation of BMSCs by Ce through Smad1/5/8 signaling pathway 650 4090 4086 860 659 PMC4156532__F9 Sestrin2 Promotes Unc-51-like Kinase 1 (ULK1)-Mediated Phosphorylation of p62/sequestosome-1 83667 8408 9817 29110 PMC4160261__F1 Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease 2475 8408 3920 PMC4167887__F1 Schematic overview over the creatine pathway 2628 2593 1152 1158 PMC4168074__F1 Model proposed by Rakoff-Nahoum et al 7099 7097 4615 PMC4174460__F1 Seven FDA-approved agents for the treatment of kidney cancer targeting the von Hippel–Lindau (VHL) tumour suppressor pathway 7428 2475 7039 1956 PMC4177022__F6 Proposed mechanism of testicular apoptotic response to x-ray exposure 355 57099 317 841 843 842 330 840 PMC4177360__F5 TLR signaling and CXCR4/7 in human liver MDB formation 7099 7098 4615 7852 619501 PMC4180336__F2 Bile acid biosynthetic pathways 1593 1581 9420 1582 PMC4184910__F1 Schematic diagram and proposed model for the metabolic regulation and coordination of the leptin mediated reproductive and nutritional axes 23237 4160 4852 181 5443 3953 3643 3479 PMC4197569__F2 Proposed model for autophagy that implicates PLD 5338 2475 1499 PMC4198062__F8 Possible mechanisms by which phosphorylation of PAGE4 at T51 could potentiate the transactivation of c-Jun but weaken its affinity for c-Jun 204851 9506 7295 PMC4199747__F6 PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status 23604 63924 10401 6774 PMC4205853__F2 Schematic comparing signaling cascades activated by EPO in microglia and macrophages 3717 1499 2475 PMC4212952__F4 Network pathway analysis of differentially expressed genes in different subgroups of patients and controls 6775 3109 5308 3115 6282 85329 PMC4214059__F1 A causal model specifying how genetic variation increases the susceptibility to clinical disease through smoking and alternate pathways () 260431 1143 1136 1138 PMC4214761__F5 Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma 64167 4282 9945 972 5266 1513 7037 100187907 PMC4215229__F6 A model of FGFR4-mediated metabolic regulations 2264 1581 26291 9965 PMC4220672__F1 Novel strategy for the use of leptin for obesity therapy 3953 3717 6774 PMC4234705__F2 Eph Receptor Tyrosine Kinases in Cancer Stem Cells 1969 2042 2475 PMC4238899__F1 Organisation and lineage control in the intestine 430 474 4760 PMC4262777__F4 Tumor-derived exosomes are secreted via a constitutive/inducible pathway that can be activated by a p53-mediated response 355 7157 5874 PMC4272425__F9 Proposed model of Pofut1 involvement in commitment of myogenically differentiated cells through activation of the Notch signaling pathway 23509 5081 4151 PMC4276873__F7 Tpl2-ERK activation during TLR signaling 929 7099 7097 6850 114609 4615 51284 7098 54106 PMC4290704__F1 Signalling pathway and endogenous antagonists of IL-1B and IL-18 10068 7850 3553 4615 PMC4292729__F1 Molecular and cellular mechanisms of immunogenic cell death 325 3553 3458 PMC4292999__F5 Co-expression of the Wnt signaling pathway with CITED2 in spondyloarthritis (SpA) 7471 7480 8322 4920 10370 PMC4300205__F1 Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes 4838 4087 4088 PMC4301186__F1 Interplay between lifespan regulation and brain function 23411 100132074 2475 PMC4303659__F10 Working hypothesis for how the PGRN/PIRO axis regulates the formation of multinucleated osteoclasts 7189 126014 4772 PMC4308035__F1 Proposed pathways by which prostate cancer cells activate AR signaling, including variants (AR-Vs), and thus acquire resistance to AR-directed therapy 3479 3569 367 PMC4309199__F2 Toll-like receptors and IL-1 receptor family signaling pathways 10333 7100 7097 7099 51284 7098 4615 PMC4314091__F1 Unusual Case of Porcupine 1499 4041 4040 324 54894 7008 PMC4322524__F1 Signalling pathways that control maintenance of BCSCsWnt binds its co-receptors: Frizzled (Fz) and LRP5/LRP6 6469 4040 4041 2932 324 1499 PMC4351630__F6 Schematic summary of the effects mediated by RA-NPs against MPTP-induced injury in the dopaminergic (DA) nigrostriatal pathway of adult and old mice 4280 7054 5309 PMC4362832__F2 Standard pathway by which microRNAs are processed and loaded onto RISC to regulate gene expression 7018 29102 54487 PMC4373423__F10 Suggested model for RF effects and interactions in various mouse tissues 23411 7124 5465 PMC4383680__F10 G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons 181 4160 4852 5443 PMC4384112__F3 IFN-induced signaling through the JAK-STAT pathway 3454 3455 7297 3716 8554 10379 PMC4384349__F5 Schematic presentation of VEGFR-1 activation in CC tissue and its association with metastasis 5281 7423 7422 PMC4384471__F2 Interferon (IFN) signaling via the JAK–STAT pathway 3459 3454 3455 163702 3460 7297 3717 3716 PMC4396743__F7 Proposed model of signaling pathways activated in primary NHP microglia in response to B 7096 7099 7097 7100 4615 64127 6347 3576 7124 PMC4400057__F3 NEMix: Single-cell Nested Effects Models for Probabilistic Pathway Stimulation 55799 1956 5582 5321 PMC4407676__F2 The two representative networks by ingenuity pathway analysis (IPA) for differentially methylated whole gene set derived from HF-dNK-treated EVT 26508 7410 8425 PMC4414174__F9 Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer 7186 9618 2475 PMC4420620__F2 Novel functions of viral anti-apoptotic factors 3466 7297 3716 3661 3665 3662 PMC4423995__F1 Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration 773 9423 775 1630 5577 6262 4775 PMC4424075__F3 Innate Immune Evasion by Filoviruses 3454 3455 7297 3716 6773 PMC4424084__F1 RIG-I signaling pathway 54941 7706 57506 1283 8717 10010 29110 3661 PMC4424351__F9 The role of UV radiation in the modulation of STING-dependent IRF3 activation 115004 55626 8408 29110 3661 PMC4426976__F2 Can we safely target the WNT pathway? 4040 4041 54894 84133 55366 8549 1499 PMC4427301__F4 Downregulation of Notch Signaling Pathway in Late Preterm and Term Placentas from Pregnancies Complicated by Preeclampsia 10683 3714 54567 182 4853 4854 23493 23462 PMC4428600__F1 Wnting out ocular neovascularization: using nanoparticle delivery of VLDL receptor extracellular domain as Wnt pathway inhibitor in the retina 1499 4040 4041 PMC4433804__F1 Catalytic mechanism of a retinoid isomerase essential for vertebrate vision 6121 9227 5959 PMC4436943__F1 Wnt/Beta-catenin signalling pathway 1499 324 4041 4040 PMC4438184__F10 Aldosterone-induced inflammatory responses: role of the ADAM-17/TGFA/EGFR axis and modulation by paricalcitol 1956 7039 6868 6772 PMC4440595__F2 The BMP/SMAD signaling pathway 654 4090 4086 4089 4092 3397 PMC4442787__F3 Of BK regulation, painful connections, and versatile neuropeptide signaling 181 4160 4852 5443 PMC4449096__F1 Signaling pathways through which macrophages regulate Beta-cell replication 1499 4087 1950 1956 PMC4449425__F2 Activation of canonical (Wnt–Beta-catenin) pathway 4041 4040 1499 324 2932 PMC4452148__F3 Wnt/Beta-catenin signaling pathway 4040 4041 324 2932 1499 595 7008 51701 PMC4453519__F3 Activation of the cytokine-cytokine receptor interaction pathway in incubations with BL21 or W3110 91 5155 2322 3579 652 1235 8744 7124 1437 3586 7412 7128 8743 PMC4453619__F7 Molecular genetic model (adapted from ; ; ; ) 7855 1499 6928 4040 4041 PMC4459582__F7 Kruppel-like factor 5 is required for perinatal lung morphogenesis and function 688 5742 7042 7048 5155 650 659 5156 2246 658 130399 90 7869 2263 8817 269 PMC446107__F1 TLR signaling pathways 7096 7097 10333 7099 4615 114609 4118 51311 54106 7098 51284 3661 PMC4467418__F7 miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells 100302242 174 5728 PMC4471869__F3 Interleukin-33 in tissue homeostasis, injury and inflammation 90865 85480 260431 PMC4476649__F1 Regulation of Lymphocyte Function by Adenosine 84890 50943 3565 912 PMC4479266__F8 Sry-type HMG box 18 Contributes to the differentiation of Bone Marrow-derived Mesenchymal Stem Cells to Endothelial Cells 1958 54345 7450 4208 PMC4481438__F1 Effect of ileal bile acid transporter in the proximal ileum 1593 9420 1582 PMC4483595__F4 Proposed mechanism to explain the protective effect of CFHR1,3 deletion on the development of IgAN 718 3078 10878 PMC4484476__F7 Inhibition of Beta-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear Beta-Catenin/TCF-1 complex: Critical role of STAT-3 324 2932 1499 6774 PMC4485443__F1 Structural determinants of SMAD function in TGFB signaling 4090 4086 4088 4092 4089 51592 4087 4091 PMC4488779__F2 Proposed model of the vitamin D-dependent antimicrobial pathway 64127 57817 1628 7421 7097 7096 958 PMC4496485__F2 STAT3 signal transduction pathway 7297 6714 9021 6774 PMC4508501__F3 Altered steps in miRNA biogenesis lead to cancer 29102 57510 23405 6895 PMC4513218__F1 Part of the tamoxifen metabolic pathway 1565 1555 1559 1557 1576 PMC4521019__F2 Regulation of hepcidin expression by iron and inflammation 654 7036 148738 3077 3716 3717 4090 4086 6774 PMC4524397__F5 Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity 10875 5817 201633 50943 PMC4537692__F8 Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression 5310 10014 7942 PMC4539082__F2 Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway 4088 4087 4089 PMC4546481__F4 Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth 1291 3717 6772 PMC4550442__F3 Acetylation of IFNAR-ISGF3 pathway is required for the antiviral activity of IFNA 3454 3455 6773 10379 PMC4553385__F2 Treg suppression 324 941 942 3586 PMC4555691__F1 Schematic representation of sarcosine pathway 27232 1757 51268 PMC4560409__F8 Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway 929 7099 6850 5894 3565 4318 6367 PMC4561307__F8 The changes in soleus muscle gene expression within the TGFB and BMP pathways, with SCI (a) and acute response to treadmill training (b) 10468 4091 4086 4087 4090 4088 4089 PMC4562327__F1 Transition of primordial to primary follicles 54361 668 399823 268 2661 654 9210 9365 367 2492 PMC4563693__F7 Harnessing endogenous stem/progenitor cells for tendon regeneration 642658 1281 7431 3371 64102 PMC4574301__F1 Intestinal epithelial barrier function plays an essential role in maintaining intestinal health 6868 8517 1294 57217 50616 PMC4578258__F1 The schematic model for the regulation of the transcription of the srf operon network involved in two extracellular signaling peptide-mediated quorum sensing in B 1311 4827 266710 PMC4580090__F1 Role of STAT3 in lung cancer 1956 3717 6714 3569 6774 PMC4580101__F5 How the embryo makes a limb: determination, polarity and identity 2737 2253 6469 9464 3206 3209 3207 3236 3237 3239 3238 PMC4581331__F4 Biological mechanisms of MALAT1 in CRC 1499 6421 58155 PMC4599277__F7 Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-Beta-catenin signaling axis in a microRNA-34a dependent manner 6774 2932 324 1499 7471 PMC4601608__F4 Schematic drawing summarizing the physiological regulation of the melanocortin pathway and pathological findings in the in Ankrd26−/− mice 1325 4160 6774 23237 5443 4280 PMC4611759__F2 Cellular response to IFNs 7297 3716 103 6772 PMC4615692__F1 Bile acid metabolism and signaling in cholestasis, inflammation and cancer 1593 80270 9420 1582 PMC4624194__F1 STAT3 Signaling in Polycystic Kidney Disease 3082 1950 3717 6774 6714 PMC4624682__F5 Proposed model illustrating the multiple signaling pathways by which PGRN (Atsttrin as well) exerts its anti-inflammatory actions 50943 7186 8717 PMC4626744__F2 Enzymes involved in PGE2 synthesis and metabolism 5321 5320 5322 5743 5742 8644 9536 80142 10728 1646 1645 3248 PMC4629055__F2 Divergent macrophage activation pathway 6347 6367 6362 6361 PMC4629213__F1 Bile acid synthesis and metabolism 1593 1581 9420 1582 PMC4632778__F10 Schema of osteogenic differentiation through the BMP signaling pathway and possible regulation by PARP activity 650 4090 4086 4089 860 PMC4637164__F1 Activation of the complement cascade and its role in tumorigenesis 720 718 727 10747 5648 730 729 735 PMC4643662__F2B Proposed signaling mechanisms of S100A8/A9 in pancreatic-cancer cells.S100A8/A9 could interact with RAGE, leading to the activation of MAP kinases and NF̃KB signaling 6279 6280 7099 2475 PMC4650800__F5 Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling 7040 4314 4318 PMC4653031__F7 Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells 3488 3480 3091 PMC4654310__F6 Schematic model of SOCS-1 induction in a TLR4/MyD88-dependent and IFN-Beta-dependent signaling pathway 7099 3716 4615 6772 PMC4662480__F6 Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma 6714 7297 3717 8195 6774 PMC4666639__F6 Fn14, a Downstream Target of the TGFB Signaling Pathway, Regulates Fibroblast Activation 4089 4087 4088 PMC4681406__F7 Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche through a Unique Signal Transduction Pathway - An Approach for Treating Bone Disease in Diabetes 51094 26060 4086 9242 4318 4090 PMC4682238__F1 Schematic representation of Slit-Robo signaling pathway in gastric tumorigenesisᅟ 9353 6091 57522 1499 2475 595 22943 PMC4686057__F1 Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators 3914 3679 3912 3672 960 3918 3909 1293 8515 1287 1278 1285 1282 1286 1290 1284 7057 1289 7058 1301 1292 22801 1281 961 7059 131873 1277 3673 1288 3675 1291 PMC4688235__F2 Recent advances on viral manipulation of NFKB signaling pathway 115004 3428 54106 51284 7098 57506 4615 6352 PMC4692127__F8 Downregulation of the Canonical WNT Signaling Pathway by TGFB1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics 3479 7482 1499 22943 81029 PMC4693890__F3 Cytokine signalling networks in women with chlamdyial infections (a) or gonorrhoea (b) were evaluated using Ingenuity Pathway Analysis 6356 4050 6351 PMC4697149__F1 Enhanced inflammatory gene expression by IL1B; feedback control by DUSP1 and feed-forward control by ZFP36 3553 1843 7538 7124 PMC4698100__F8 Regulatory functions of STAT3 in cardiac Beta-adrenergic functions 6714 6774 153 8912 PMC4704338__F1 Activation of the Notch signaling pathway 1950 100188776 3480 PMC4710564__F7 Specialized pro-resolving mediators (SPMs) inhibit human B-cell IgE production 3716 3718 6778 PMC4711336__F1 TGFB signaling and regulation 100187907 25805 4087 4092 PMC4714141__F4 Pathway of miR-7 in hepatocellular carcinoma 3236 1956 898 2475 619501 PMC4716080__F1 Wnt-Beta-catenin signaling pathway 4040 4041 324 1499 960 PMC4733034__F2 Assay for defining the immunostimulatory potential of different RNAs 3661 3665 10379 PMC4735799__F8 Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system 1950 374 1956 6935 PMC4736209__F1 Main pathways of TRP degradation including enzymes and their potential stimuli (modified after [, , , ]) 15 8564 8942 PMC4738716__F5 Network of TREM1 and PTGS2 (COX-2) upstream regulators and their target molecules, evaluated in the peripheral blood cells of breast cancer patients compared with healthy donors (Ingenuity Pathway Analysis) 374 2919 9547 3655 7852 3579 54210 5743 4929 1843 1959 1960 1051 2353 4683 PMC4742202__F5 Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development 7157 4585 2064 865 2625 5290 PMC4742793__F9 Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin 7476 4040 4041 PMC4747023__F3 Unique genetic and epigenetic mechanisms driving signatures of paediatric diffuse high-grade glioma 5156 2260 3480 1325 5290 673 5728 PMC4747493__F8 Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer 3569 1950 1956 1848 1846 1843 PMC4747705__F6 BRAF(V600E)-directed recruitment of MAFG and its corepressors to CIMP and HIM gene promoters 4097 1789 571 57680 PMC4747906__F1 Epidermal growth factor receptor (EGFR) is restricted to the basal surface of the airway epithelial cells 1950 1956 3383 PMC4750108__F1 Working model of the innate immune sensing of tumors leading to spontaneous T cell responses in vivo 115004 29110 3661 PMC4754612__F1 Stimulator of interferon genes (STING)‐mediated cytosolic DNA sensing pathway 115004 51428 1777 29110 3661 267 PMC4760904__F6 Agrin and LRP4 are central to a chondrogenic signalling network 22943 6662 1280 176 4322 4038 4040 4041 PMC4766307__F1 Recruitment and activation of bone marrow-derived fibroblasts in renal fibrosis 6366 3718 6778 58191 6347 4088 PMC4770016__F2 ITK acts as a rheostat for the TCR signaling pathway 3932 7535 3702 969 3662 PMC4773219__F4 Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy 84441 7316 6955 PMC4778288__F5 CRHR1 alterations in CRPS patients and schematic representation of miR-34a mediated repression of CRHR1 regulating POMC expression and BMI a CRHR1 was significantly higher in poor responders than in responders 1394 407040 5443 PMC4794511__F3 miRNAs and TGFB signaling pathway 4087 4088 3488 3479 PMC4806539__F2 Biological networks according to IPA of 1370 genes related to HNSCC 4792 4790 672 PMC4809369__F6 Activin/Nodal signaling pathway in human ESC self-renewal 4838 4087 4088 79923 PMC4809675__F1 TNF biology, pathogenic mechanisms and emerging therapeutic strategies 7124 8717 7186 197259 PMC4810646__F1 OAS-RNase L pathway 7297 3716 3433 3434 9636 6772 6773 3454 3455 6041 PMC4810800__F2 TGFB1/SMAD signaling pathways in hepatic fibrosis 655 4087 4088 4086 4090 4089 4092 PMC4811915__F9 Proposed model for the role of the Wnt/Beta-catenin pathway during odontogenesis 22943 652 1499 PMC4814376__F1 Summary of metabolic FGFs 9965 26291 2246 2260 2264 PMC4817777__F5 Regulatory pathway leading to colon cancer–promoting splicing aberrations 4609 5725 5315 PMC4817806__F8 Proposed mechanism by which DZNep epigenetically reactivates Wnt/Beta-catenin signaling to promote osteogenic differentiation of osteoporosis BMSCs 2146 7471 7475 80326 PMC4824345__F7 The GacS/A-RsmA Signal Transduction Pathway Controls the Synthesis of Alkylresorcinol Lipids that Replace Membrane Phospholipids during Encystment of Azotobacter vinelandii SW136 411 410 414 PMC4824608__F1 Various possible mechanisms of Ca2+-ITPR-mediated control of autophagy 7052 3313 596 2475 57192 8408 9706 7942 PMC4825016__F7 Proposed model for cross-talk of IGF1 and integrin signaling 3479 3480 6714 PMC4837953__F2 Characteristics of the interplay among RIPPLY2, TBX6, and MESP2 and their relation in the notch signaling pathway and L/R axis determination 6911 145873 134701 4838 PMC4849425__F2 Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation 3122 23624 1050 3082 7043 PMC4851234__F2 Negative regulators of necroptosis 7124 8717 8737 331 7186 11035 5495 197259 PMC4854363__F3 Negative regulatory NLR functions during viral infection 79671 197358 91662 7189 7187 57506 3654 29110 PMC4874878__F6 Altogether, our findings are summarized in 2194 1581 7124 3553 3606 6955 PMC4879750__F1 TGFB signaling in fibroblasts 50507 4089 4088 PMC4889582__F2 TLRs reside on the plasma membrane or intracellularly on endosomes and act via the MyD88 or the TRIF pathway leading to the activation of downstream signaling pathways 7096 7097 10333 7100 7099 4615 3661 54106 51311 51284 7098 PMC4890987__F14 Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells 7189 9261 1649 4149 51347 9252 2353 5606 4615 54106 3398 PMC4891098__F6 WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells 3611 7424 100126297 PMC4892757__F1g MicroRNAs targeting TGFB signalling underlie the regulatory T cell defect in multiple sclerosis 7046 7048 4087 4092 4089 100126333 50943 PMC4899284__F2 The de novo thymidylate synthesis pathway as a nuclear multienzyme complex at sites of DNA replication 4522 7298 1719 PMC4900635__F7 MACC-1 Promotes Endothelium-Dependent Angiogenesis in Gastric Cancer by Activating TWIST1/VEGF-A Signal Pathway 346389 7291 7422 2638 PMC4907392__F6 Crosstalk network constructed by Xtalk from the NFKB Pathway (A) to the Neurotrophin Pathway (B) using the KEGG-family network 5599 3725 2353 PMC4909418__F1 Smoothened-dependent and Forkhead box C1 transcription factor-induced Smoothened-independent Hedgehog signaling 6608 5727 2736 2296 PMC4910120__F3 Overlapping type I, II and III IFN signaling pathways 56832 3458 3717 3716 7297 6773 6772 PMC4914733__F7 Proposed signaling mechanisms mediated by Lipoxin A4 in preventing intestinal epithelium cells from intestine ischemia reperfusion (IIR) injury 1610 2169 9817 PMC4919901__F2 Allergic Mechanisms of Eosinophilic Oesophagitis 324 4155 7040 PMC4926737__F2 Disruption of postsynaptic differentiation pathway by muscle-specific kinase (MuSK) autoantibodies 4038 4593 285489 PMC4931624__F1 The Wnt signaling pathway and possible points for therapeutic interventions to restrict S100A4-mediated tumor progression and metastasis 6275 22943 4040 4041 2932 324 1499 PMC4941299__F8 Involvement of SULF2 in Gamma-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression 55959 1499 6774 PMC4960006__F7 Diagram represents the proposed model of APC regulation of miR-17-92 cluster 324 2932 1499 6925 5728 PMC4970451__F1 Migration of opioid-containing immune cells and opioid release within inflamed tissue 3383 3576 3553 PMC4973584__F1 Lmx1b and miR135a2 in modulating the Wnt pathway and influencing midbrain size, mDA progenitor specification and neurogenesis 7471 324 2932 595 4010 406926 196475 PMC4974939__F3 Activation of “RNA-sensing” TLRs on neurons and microglia triggers distinct effects 7098 51284 7124 3603 PMC4986693__F6 Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2 and P-ERK 887 1958 595 PMC4993159__F1 Hepcidin Regulation in the Anemia of Inflammation 3569 148738 164656 6774 3077 57817 PMC5009769__F1 Wnt pathway regulation of intestinal stem cells 22943 11197 4040 4041 324 2932 1499 960 595 PMC5022081__F1 Post-translation processing of Klotho protein 1431 102 6868 PMC5023632__F9 Possible mechanism for cross talk between P2X7 nucleotide receptor and canonical Wnt signaling pathways in cells of the osteoblast lineage 89780 2932 1499 4827 PMC5030800__F10 The regulation of lysosomal biogenesis and autophagy by cathepsin B in response to infection with F 7942 1508 8408 2475 PMC5040924__F12 Activation of NFKB and STAT signaling pathway 3458 3553 929 3716 3717 6772 PMC5041017__F1 IFN signalling pathways induced by IFNA/B and IFNG (see text for details) 3459 3460 3455 3454 7297 3716 3717 6773 6772 PMC5053108__F7 Role of miR-9 in zebrafish brain development.Notes: (A) Zebrafish forebrain: In the forebrain, miR-9 inhibits proneural gene her6 and targets Fgf signaling pathway genes (dusp6, pea3) 619511 85416 1848 1995 2260 2253 PMC5069086__F6 Schematic model for HCV-induced CD4+ T cell senescence regulated by the ΔNp63–miR-181a–Sirt1 and ΔNp63–miR181a–DUSP6 signaling pathways 23411 1848 50943 PMC5070595__F2 Relevant aspects of complement activation and inflammasome activation with their possible interconnection 114548 718 3553 PMC5071566__F8 Modulation of host AKT pathway by L 2932 1499 94234 PMC5071578__F5 Role of TSN in carcinogenesis 7247 3486 7040 58191 6282 PMC5076460__F5 Global gene profiling of aging lungs in Atp8b1 mutant mice 490 4151 491 PMC5076483__F4 Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events 1786 1789 1788 6996 PMC5082389__F5 IL-17 F signaling pathway is epigenetically altered in malignant COPD and non-malignant COPD lung airway epithelial cells 2919 3934 84818 PMC5105987__F12 PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases 11047 6531 84131 22999 26059 815 6949 1044 5159 PMC5118777__F3 Schematic indicating the role of cellular and EBV miRNAs in EBV latency and reactivation 406984 554210 9839 6935 406947 3097 1051 PMC5123285__F8 LRRC4 as a tumor suppressor in glioblastoma 1950 64101 1956 7018 PMC5127148__F1 Expression of myogenes in longissimus dorsi muscle during prenatal development in commercial and local Piau pigs 51684 221662 126272 83595 22808 57680 55662 5604 4656 3551 8048 84870 51176 PMC5130170__F1 Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway 1950 2885 1956 PMC5132394__F8 iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration 4314 89780 2932 324 1499 81029 PMC5134889__F2 Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases 3932 3702 5335 27040 7535 PMC5135602__F1 PPARD mediated gene regulation 1374 5166 1499 3714 652 3458 3569 PMC5137695__F5 Summary model of Tri-DAP activity and pathway utilization in HCMV-infected cells 10392 8767 29110 3661 PMC5138853__F6 Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway 3589 3590 6774 PMC5143376__F8 Hypothetical model of TMEM2 exerting its antiviral functions 7297 3716 10379 4938 PMC5143481__F2 TLR4 signaling mechanisms 7099 929 114609 4615 3553 PMC5154826__F2 Hedgehog Signaling in the Stomach 6469 3458 3553 9242 PMC5155223__F6 Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma 6091 55740 23380 653464 PMC5166507__F1 Model for the cycling of ULK1 protein levels, which modulates the oscillatory mode of the autophagy response during prolonged starvation 8408 2475 23327 PMC5167048__F3 Age‐associated defects interfering with function and survival of activated T cells 1958 6772 1846 969 PMC5168844__F1 Network structure for RAS signaling pathway in Head and Neck Squamous Cell Carcinoma (HNSC) 4790 572 1956 9846 5594 3815 5578 5601 5894 PMC5187527__F4 Mechanism of estradiol-dependent repression of GD3S in ER-positive breast cancer cells 7124 2813 6489 PMC5223230__F1 A central role of Batf3 DCs and the STING pathway in orchestrating anti-tumor T cell responses 55509 6351 4283 3627 PMC5260495__F8 A schematic diagram shows that CD9 binds to gp130 and stabilizes gp130 by blocking its ubiquitin-dependent lysosomal degradation to promote the BMX-mediated STAT3 activation in GSCs 3569 928 660 6774 145258 PMC5260888__F7 Role of RIPK1 in ConA hepatitis model 8717 8737 7186 PMC5261008__F6 The multi-targeted STAT3 and TLR9 for aGvHD therapy 54106 324 6774 920 PMC5266810__F1 Interorgan crosstalk involved in Beta-cell failure 3375 3553 3603 PMC5274667__F3 Molecular mechanism governing ANGPTL4-mediated TG hydrolysis 7038 51129 338328 PMC5274707__F1 Neutrophil crosstalk with immune and humoral cells and relevant chemical signals that influence and compose the inflammatory response and pathway to resolution via the neutrophil 7098 7099 4353 4283 54106 PMC5282886__F6 IGF-IR signaling in CSCs-like cells biology 2475 6774 79923 PMC5286961__F1 A scheme of the mutant p53–Nrf2–proteasome pathway with chemotherapeutic intervention targeted at mutant p53 and the proteasome 9817 3845 673 PMC5294958__F1 TGFB/Smad4 signaling pathway 4087 4088 4091 4089 PMC5299619__F1 The canonical T2R signaling pathway 29850 5330 255022 PMC5306231__F2 Possible cell-cycle checkpoint pathways in centrosomal (centriolar) integrity or morphology 81565 10733 57646 PMC5323377__F10 Schematic representation of the difference between Ctenopharyngodon idella melanoma differentiation-associated gene 5 (CiMDA5) and C 3665 3661 2335 PMC5323396__F2 General overview of the Wnt signaling pathway 4040 4041 324 387 1499 PMC5332411__F3 IFN pathway of elephant shark 3660 3661 3662 3664 3665 3394 10379 8835 9021 122809 8554 9063 10401 51588 3455 3466 PMC5332470__F1 T cell differentiation and the emergence of CMV-induced T cell phenotypes 920 1236 939 940 PMC5333072__F1 MNT and its place in the MAX-MLX network of interacting proteins 4335 4149 4610 4613 6945 22877 4609 4084 10608 83463 23269 PMC5348391__F9 Neurokinin-1 receptor is a novel positive regulator of Wnt/Beta-catenin signaling in melanogenesis 2932 324 1499 4286 PMC5348720__F1 Viral infections in type 1 diabetes mellitus — why the B cells? 7124 3553 7297 3716 5771 11274 1512 3662 3664 3663 3661 3665 6772 60468 169792 PMC5350572__F8 Illustration shows the proposed overall mechanism by which butyrate inhibited proliferation and induced apoptosis in hepatic cells 23411 5728 1499 PMC5355296__F2 Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase 9586 467 3569 1958 10628 1647 PMC5359838__F5 Schematic representation of the opposite p53-TRIM8 and N-MYC-miR17-5p/miR106b-5p networks in cellular response to treatments 406900 81603 407040 PMC5360391__F6 Proposed hypothesis for the effect of melittin on formation of osteoclast-like MNCs 7189 3553 4772 PMC5361607__F1 PRKCD-AKT-MTOR-ULK1 signaling pathway for autophagy suppression in cisplatin nephrotoxicity 6714 5580 5170 2475 8408 PMC5363569__F8 Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone 10631 7040 7474 7422 9881 PMC5364987__F2 Different pathogenic roles of ER-resident and cell surface HLA-B27 dimers 3812 149233 567 PMC5368067__F1 Wnt signaling pathway and targets of small‐molecule inhibitors 4040 4041 22943 92162 324 1499 607 PMC5370040__F1 Tumour-derived exosomes as a signature of pancreatic cancer - liquid biopsies as indicators of tumour progression 977 975 967 928 4827 PMC5374157__F1 Type I interferons (IFNs) and different other cytokines are essential for natural killer (NK) cell homeostasis and function 3558 59067 3600 3606 3455 3454 3716 3718 3717 7297 4615 7189 PMC5374883__F11 Proposed pathway of TGFB2–TLR4 signaling crosstalk in the glaucomatous TM 7099 4615 25805 PMC5376156__F1 Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/Beta-catenin Signaling Pathway 1499 595 6662 PMC5381981__F1 Metabolic scheme of targeted oxylipins 5226 4049 4050 4015 PMC5391460__F9 NEAT1 exerts antihantaviral effects by acting as positive feedback for RIG-I signaling 55601 57506 7187 6421 3665 PMC5391975__F3 Signaling networks activating the canonical RAF-MEK-ERK signaling pathway and that have been involved in SCLC metastasis (see text) 6387 3082 2247 7852 PMC539208__F2 MAPK pathway 1380 1378 673 10142 3725 4609 2353 PMC5392598__F4 Schematic overview of the sex development gene regulation network 6736 6662 56956 2254 2516 54361 1499 668 284654 PMC5393505__F3 Network of damaging mutations in ACC associates to the TP53 pathway 919 4771 2051 9886 7157 8886 7013 6495 PMC5406035__F5 RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection 11035 8737 57506 3661 PMC5407986__F1 Mitochondrial Control of Innate Immunity and Inflammation 3454 1283 57506 3665 3661 6772 6773 PMC5408751__F7 GSK-3B modulation of LKB1-AMPK pathway in autophagy induction 2932 2475 8408 PMC5412337__F1 Current strategies for targeting the epidermal growth factor receptor (EGFR) pathway 1950 3082 6774 2475 PMC5413082__F1 Schematic of growth hormone and IGF-1 axis 2691 3479 3480 2690 PMC5415623__F7 Schematic pathway for low-dose PTX inhibition of cell growth in colorectal carcinoma cells 2744 6510 23657 PMC5416929__F8 Working model of TGFB and NFKB pathway interactions that regulate GCT viability 7042 4088 4087 PMC5425748__F2 Illustration of the multiple signalling pathways for TGFB in the VSMC In the normal state, TGFB is sequestered by microfibrils, bound to fibrillin-1 through LTBP-1 and fibulin-4 interactions, until its required release 4052 7048 7046 PMC5426657__F7 Protective effects and functional mechanisms of Lactobacillus gasseri SBT2055 against oxidative stress 1728 2729 3162 PMC5434467__F1 The structure of IL-35 and the activation of the JAK-STAT signaling pathway 10148 3595 3717 6772 6775 PMC5447318__F2 Infection of virus can stimulate airway epithelium and produce antimicrobiota defense through IL-22/IL-22R signaling pathway 6280 7097 54106 7098 7099 PMC5452017__F3 Brain metabolism in health, aging, and neurodegeneration 3157 65985 47 PMC5460122__F6 Lipotoxicity-induced NLRP3 inflammasome activation in TEC 948 3949 114548 23411 3553 7099 10333 PMC5460696__F1 Schematic of androgen synthesis illustrating the classic androgen pathway (gray boxes) and the steroids of the 11-oxygenated androgen pathway (black boxes) 1586 1528 8644 1584 3291 PMC5464113__F2 Genes found to modulate the accumulation and secretion of different aggregated species of aSyn 51762 5873 5872 8766 PMC5466420__F10 Illustration depicting the roles of Yap in submandibular gland epithelial development 9113 26524 1956 3861 2069 PMC5467995__F1 Major intracellular pathways leading to Type-I-IFN production 64127 115004 57506 7098 3661 3665 6772 6773 3716 7084 3454 3455 PMC5472757__F9 DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity 11277 115004 3661 PMC5477726__F1 BMP4 signaling pathways 652 9241 659 657 658 4090 4086 4089 4092 4091 PMC5478005__F1 Wnt/Beta-catenin signaling pathway 4040 4041 324 2932 1499 7008 PMC5484415__F7 From Krebs to Clinic: Glutamine Metabolism to Cancer Therapy 2744 2475 4609 PMC5495030__F1 Canonical TGFB signaling pathway 4087 6497 4088 4089 PMC5502539__F4 Complement factors are targets for pharmacologic inhibition in retinal disease 727 1675 718 PMC5507876__F8 The diagram of rGal3C regulating NDRG1 through integrin/FAK/SRC pathway 6714 10397 619501 PMC5510910__F9 Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum 6850 114548 3553 PMC5512069__F8 The role of BMP4 in regulating hyperandrogenism development 652 367 4090 4086 4089 1586 1588 PMC5517153__F1 Pathway for thiopurine metabolism 7172 8833 5879 PMC5518631__F1 Agrin signaling and YAP in neuromuscular junction formation (NMJ) and liver cancer development 619501 4593 4038 PMC5520163__F1 How the MyD88 pathway triggers the ubiquitylation of IRAK1 4615 51135 3654 7189 PMC5520447__F8 The functions of miR-26a/b-Jagged/Notch axis in modulation of EMT and fibrosis 4088 4087 4089 100188776 PMC5521196__F5 Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function 51176 1499 64321 PMC5527950__F2 Internalization routes influence signaling output 1499 4040 89780 1956 PMC5528541__F9 A working model of Lhx2‐induced tumor progression 5159 4087 4088 4089 9355 5155 PMC5533708__F6 TANC protein interaction network 7529 85461 26524 26115 23043 7791 23513 PMC5533789__F6 Hypothetical signalling network and status in bovine cumulus cells modified by FSH-priming based on RNA-seq expression signature 7040 3037 7130 5806 3665 PMC5540723__F3 VEGF/VEGFR signaling and the approved therapeutic agents targeting this signaling 7424 7422 7423 PMC5541090__F1 NREP, HIPK2, PRDM16, SMAD3 and their roles in the canonical TGFB signalling pathway 9315 7046 7048 4087 4088 4089 28996 63976 PMC5557355__F7 Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis 2020 2475 2019 PMC5561110__F12 Schematic representation of C5b-9-induced lysosomal dysfunction that inactivates autophagy in podocytes 730 729 735 PMC5570368__F8 Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing 5467 5468 7068 5465 6256 2908 PMC5571543__F8 Proposed mechanism of ESA‐mediated downregulation of Foxp3 in regulatory T cells 4088 4087 4089 50943 PMC5594916__F6 Schematic illustration shows targeting of the hnRNPA1/pri-miRNA-18*/K-RAS pathway by miR-25-3p and miR-15a-5p 3178 29102 54487 PMC5600869__F3 Passive DNA demethylation pathway 1788 1789 1786 PMC5610833__F1 Catecholamine synthesis pathway 7054 1312 1621 5409 PMC5613704__F1 Acute and chronic effects of plasma Ang II, aldosterone and EO on brain angiotensinergic pathways 367 4922 6651 551 627 PMC5614322__F2 Hypothetic pathogenesis of OPLL 6662 860 7933 9242 PMC5617461__F9 Overexpression of stathmin plays a pivotal role in the metastasis of esophageal squamous cell carcinoma 3872 3866 3925 3868 3672 3688 3860 2633 2353 3725 PMC5620176__F9 LncRNA ANCR down-regulation promotes TGF-Beta-induced EMT and metastasis in breast cancer 8841 282 860 PMC5622153__F2 Neuregulins proteolytic cleavage pattern by BACE1 2066 1950 23621 6868 10718 PMC5624958__F7 Schematic diagram of the proposed mechanism by which OCA may modulate the IL-6/Jak-2/STAT3 signalling pathway in HCC cells 3553 619501 3717 6774 9021 PMC5625110__F1 Src family kinase signaling in renal fibrosis 2534 3055 6714 6774 1956 4088 PMC5630004__F2 Drug targets on the TGFB signaling pathway 4088 4089 7018 PMC5643010__F2 Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s disease 4092 4087 4088 4089 PMC5649110__F1 Narni-Mancinelli et al 6375 1959 3458 8140 6850 7535 5199 PMC5655209__F8 Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10 3479 2887 2719 PMC5661375__F1 TGFB1 signaling pathway 4087 4089 4088 PMC5661375__F2 Function of TGFB1 in normal lung and lung cancer cell responses to radiotherapy 4088 4087 4089 PMC5661614__F3 Simplified signaling pathway network where Wnt/Beta-catenin, Notch and Hedgehog pathways, along with critical transcription factors including Bmi-1, c-myc, Slug and Sox9, interact with one another and contribute to the maintenance of MaSC state 1499 6662 648 PMC5665463__F6 Model for HCN4 function in establishing laterality 10021 4838 5308 PMC5665759__F3 Androgen‐regulated lncRNAs, SOCS2‐AS1 and POTEF‐AS1 promote prostate cancer growth 367 105373617 8835 728378 144481 8743 7098 PMC5666796__F9 Schematic model of possible signalling events involved in the upregulation of TGFB1 expression by LTBP-2 2147 4053 2152 PMC5666906__F6 The impact of EGFR-ERK pathway on the type I interferon response in human keratinocytes 1956 56832 6772 3659 3434 3433 6347 PMC5678904__F3 TGF‐B/SMAD/CTCF signaling pathway 10664 4088 4087 4089 PMC5688216__F1 Regulatory T cell development (Churlaud et al 50943 920 940 941 942 7006 100124696 7054 PMC5693858__F10 A schematic of the mechanism of Panax notoginseng root (PNR) in its enhancing of antiviral interferon-mediated immune responses and natural killer (NK) cell activity 29110 3716 7297 6772 3661 PMC5696218__F10 Verrucarin J inhibits ovarian cancer and targets cancer stem cells 7472 7471 4851 PMC5700476__F7 NFKB signaling pathway is activated by TLR3/TLR4 7099 7098 4615 3654 51135 7189 PMC5705614__F3 Schematic depicting the mechanical regulation of the mammalian Hippo signaling pathway 387 5879 154796 PMC5706455__F4 Red Carpet for Iron Metabolism 3603 151176 164656 3569 3570 148738 7037 3077 7036 659 92 6774 PMC5709754__F1 CD30 mediates its effects through a number of diverse signaling pathways, which in concert confer a survival benefit to the cells on which CD30 is upregulated 7186 7185 3726 PMC5711031__F10 Interleukin-1beta (IL-1B)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1B on human dystrophic myogenic cells 3553 3603 182 4854 1437 1440 PMC5719148__F1 Models for post-translational control of CHMP5 during T-cell development 9101 51510 596 PMC5722633__F4 Mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain 50944 10458 57554 22941 85358 56899 9456 80725 8831 9455 9454 10531 PMC5727324__F2 Polarized trafficking of Wnt proteins and receptors 7481 22943 7471 6259 4920 4040 7474 89780 PMC5727914__F5 Interferon signaling in HPV-containing keratinocytes 1956 56832 3458 3459 3460 3454 3455 3716 7297 3717 115004 29110 10379 3661 3665 3659 6772 PMC5732091__F6 CHOLANGIOCYTE PRIMARY CILIUM IN HEALTH AND DISEASE 85451 387 2932 324 1499 PMC5733019__F8 GHK on pulmonary fibrosis 641 3479 4318 PMC5738678__F1 Functional mechanism of the Notch signaling pathway 4855 4851 4854 54567 28514 10683 3714 182 PMC5749242__F5 The two fates of C3b generated in the retina 718 3075 3426 629 1675 PMC5751200__F2 The BMP-2 signaling pathway plays an important role in the osteogenic differentiation of adipose-derived stem cells (ASCs) 650 860 4086 4089 PMC5759931__F6 Proposed working model by which boehmenan exerted anti-proliferative activities in A431 cells 1950 1956 6774 PMC5760518__F5 Signaling pathway activated by piperonylic acid 1956 6774 1958 PMC5770148__F1 Tibim1 reduces TLR4-dependent liver damage 7099 64114 7275 PMC5772162__F2 Progranulin 627 2896 7942 4074 54664 PMC5796257__F1 Deregulated frizzled (FZD) in Wnt/Beta-catenin signaling 6662 619501 1499 8178 PMC5796261__F1 TREM2-DAP12 signaling 54209 1236 6850 1499 4703 PMC5798893__F7 Dual roles of endothelial FGF-2–FGFR1–PDGF-BB and perivascular FGF-2–FGFR2–PDGFRB signaling pathways in tumor vascular remodeling 2247 2260 2263 5156 5159 5091 PMC5808116__F8 H. pylori T4SS induces potent IL-8 induction 3240 1956 1958 PMC5817802__F3 Model for TMPRSS2-ERG regulation of the IGF1R gene 3479 2078 367 PMC5817864__F1 Rapidly induced cell autonomous bypass signaling 1956 7042 3569 2263 2261 3716 6774 PMC5823535__F1 Lessons from characterization and treatment of the inflammatory syndromes 7124 8717 7186 8737 90268 114548 PMC5827395__F1 Evasion of the DNA-sensor-mediated IFN-I signal pathway by HSV-1 115004 51428 29110 3661 PMC5830900__F1 Role of the TGFB family in mammary gland development and maturation 3082 3479 4488 PMC5834531__F6 This figure summarizes the central s-resistin downregulation effects on hypothalamic and peripheral insulin and leptin sensitivity 3717 3667 6774 5443 4852 PMC5836578__F5 Bioinformatic analysis of ATP-binding cassette subfamily A member 1 (ABCA1), revealing its preventive role in carotid plaque rupture and atherosclerosis progression during the inflammatory reaction 7376 6258 6256 19 10062 5566 8648 5465 6907 335 2168 PMC5837968__F6 Schematic illustration of SFKs mechanism of action in interferon regulatory factor 1 (IRF-1) K63-Ubiquitination 7189 3659 51311 51284 PMC5838831__F4 Sinalization cascade for genesis of medulloblastoma 6469 1499 4151 PMC5843405__F3 SUMOylation in representative cancer pathways 7124 4088 4087 4089 7046 PMC5850311__F1 Research and therapeutics—traditional and emerging therapies in systemic lupus erythematosus 941 942 933 940 958 PMC5852959__F6 CDK5RAP3 - AKT - GSK3B - Beta-catenin pathway in gastric cancer 80279 2932 1499 51176 PMC5861197__F4 The similar activation process of autophagy and NFKB pathway in response to Salmonella 81858 90268 10133 PMC5865700__F1 Shh signaling pathway 6469 6608 51684 PMC5869001__F6 Hypothesized KS biosynthetic pathway in the absence of functional B3GnT7 23563 4166 8702 PMC5877513__F1 TGF/TGFR signaling axis 51547 4089 4087 4088 51129 3576 PMC5881740__F1 JAK-STAT signalling pathway 3458 3558 3569 3716 3718 7297 3717 PMC5882219__F3 Reciprocal regulation of YAP by TRIO-RAC1 signaling and the Hippo pathway 7204 5879 864 PMC5884250__F2 Proposed molecular mechanism for maintenance of MSC stemness by cell–cell adhesion through cadherin 1000 5159 6714 PMC5892988__F1 BMP receptor signaling pathway 4090 4086 4091 4092 4089 PMC5894358__F11 The schematic diagram of potential molecular mechanisms of anti-inflammation effects of recombinant human Netrin-1 (rh-NTN-1) through UNC5B/PPARG/NFKB signaling pathway after SAH 9423 219699 4353 3383 PMC5903825__F1 Hepcidin regulation and action in non-cancerous tissue 7036 3077 151176 PMC5904225__F10 Schematic summary of the findings 3569 3576 6347 3553 PMC5907632__F1 Etirinotecan pegol metabolic pathway 1576 54658 324 PMC5913878__F2 Emerging roles of epithelial-mesenchymal transition in hematological malignancies 100507254 1499 117581 7291 6935 604 PMC5916398__F1 Initial stages of the sensitization in contact dermatites 7099 3553 7124 85480 7054 PMC5916961__F1 Mitochondria are a platform for pattern recognition receptors (PRRs) signal transduction and regulation 7096 7097 7099 3553 7189 51295 51284 10010 57506 3661 3665 114548 PMC5919715__F8 PPI and miRNA-gene regulatory networks 23401 595 894 7474 89780 5331 8322 5535 6422 166336 7477 81839 7855 PMC5922678__F1 Alterations in the steroid biosynthesis pathway in congenital adrenal hyperplasia (CAH) 1583 1586 3284 3283 1589 1585 1584 PMC5925008__F5 Summary of working thesis of the study 114548 3553 3603 PMC5930509__F9 Proposed hypothetical model depicting the involvement of miR-424/503 cluster in the Activin signalling pathway by targeting SMAD7 4087 4088 4089 4092 PMC5932357__F2 Antimicrobial autophagy is inhibited in Mycobacterium leprae infections through the activation of the type I interferon (IFN) pathway 80712 3661 29110 8638 115004 PMC5932548__F4 miRNAs in renal fibrosis 51582 4092 4089 PMC5945880__F1 Interferon-gamma (IFNG) canonical signaling pathway 6772 3659 3717 3716 PMC5954140__F7 Gene regulation of ESRRG and Wnt signaling 2104 790952 1499 6925 51176 595 PMC5954621__F2 Bile acid synthesis pathways 10858 51302 1593 80270 3283 1581 1582 PMC5955790__F1 Tumor necrosis factor A (TNF) regulation in health and disease and its sleep-linked effectors and actions 7124 1392 3565 3586 27178 2691 3569 PMC5957297__F3 MAPK pathway in BRAF-mutant melanoma 3082 1956 4893 673 4286 367 PMC5958547__F1 New Opportunities and Challenges to Defeat Cancer Stem Cells 79923 6774 6608 3577 PMC5963198__F4 Model of miR155 activation in BMDMs exposed to C 406947 6714 6850 PMC5968842__F9 Schematic diagram of how LIPUS promotes the Schwann cell viability and proliferation signaling pathway 2932 1499 595 PMC5976638__F3 The purinosome—a naturally occurring enzyme cluster? a Protein–protein interactions within the purinosome 2618 10606 5471 471 158 PMC5980186__F5 Proposed model describing the regulatory pathway between Smad7 and hepcidin expression in hepatocytes 4092 654 3077 25805 4091 4090 4086 4089 PMC5982750__F5 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand 1577 1576 1558 5243 PMC5984065__F5 TGFB induces Smad2 Phosphorylation, ARE Induction, and Trophoblast Differentiation Diagrammatic representation of the TGFB signaling pathway in SM10 growth inhibition and trophoblast differentiation 4088 4087 4089 4092 PMC5988105__F1 Currently approved and available IBD therapies include: four anti-TNF agents, namely infliximab, adalimumab, certolizumab pegol, and golimumab, and two anti-integrin agents, natalizumab and vedolizumab 7124 920 8174 PMC5988105__F2 SMAD pathway 4092 4087 4088 4089 PMC5988934__F1 Activation of antiviral innate immunity in CHB 51284 54106 51311 4615 3665 3661 5132 PMC5989395__F2 Working model of the role of lysophosphatidic acid (LPA) at the maternal-conceptus interface in pigs 5743 5328 5228 5168 4018 23566 PMC5992185__F5 Ski and SnoN protein stability by the TGFB/Smad signaling pathway 4088 4087 6497 64750 324 PMC5992481__F1 miR-24 and miR-122 Negatively Regulate the Transforming Growth FactorB/Smad Signaling Pathway in Skeletal Muscle Fibrosis 7048 7046 4087 4088 4089 PMC5992481__F5 miR-24 and miR-122 Negatively Regulate the Transforming Growth FactorB/Smad Signaling Pathway in Skeletal Muscle Fibrosis 7046 7048 4087 4088 4089 PMC5995375__F8 Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting 7412 7124 6401 PMC5999603__F8 The model of linc00462 regulation in PC 5008 100129597 7048 7046 4088 4087 PMC6006338__F5 Differential antiviral immunity to Japanese encephalitis virus in developing cortical organoids 10379 6773 6772 PMC6008986__F1 Kynurenic acid (KA) is the product of kynurenine pathway, the central metabolite of the tryptophan metabolism 56267 8942 23596 8564 PMC6016592__F2 The two faces of pannexins: new roles in inflammation and repair 3606 3553 79792 24145 PMC6021586__F5 Potential effects of miR-143 and miR-135a on signaling pathways 3597 2625 6778 4586 PMC6023907__F3 The BMP signaling cascade in osteoblast differentiation 4089 4091 6938 7291 4488 860 PMC6027159__F11 cGAS/STING signaling pathway 115004 22954 81844 PMC6028513__F2 TRIMming TGFB signals in Th17 cells 4087 4088 4089 51592 50943 PMC6029864__F1 Notch signaling on T cells 324 1493 940 9794 PMC6030168__F7 Hypothetical model showing that imbalanced LIMK1 and LIMK2 expression activates the WNT/Beta-catenin pathway and leads to CRC progression and EMT-induced metastasis 1499 3984 3985 PMC6030217__F1 Role of NUAK1 in anti-oxidant signalling 9891 4609 2932 9817 PMC6038002__F10 Tim‐3 exacerbates kidney ischaemia/reperfusion injury through the TLR‐4/NF‐KB signalling pathway and an NLR‐C4 inflammasome activation 7099 58484 7124 10612 PMC6042961__F10 FRMD8 stabilises the iRhom2/ADAM17 sheddase complex at the cell surface 1956 6868 83786 PMC6044452__F8 Possible signaling mechanism for cigarette smoke and FGF23-mediated regulation of FGFR4/PLCG/calcineurin/NFAT pathway 2264 3553 8074 260431 PMC6044872__F2 Biosynthetic pathway of O-glycans 667 55808 10610 6482 PMC6049067__F6 MiR‐26a‐5p as a novel HB repressor 389421 5901 6790 PMC6050486__F5 Schematic drawing of epigenetic reprogramming in Dnmts, Sfrp4 and Wnt/B‐catenin pathway from the foetus to offspring 6424 3091 4041 324 2932 8061 PMC6071487__F2 Interleukin 6 (IL-6) receptor-mediated signaling pathway and an IL-6 inhibitor, the humanized anti-IL-6 receptor antibody tocilizumab 8651 921 6774 9021 PMC6078181__F2 Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap 3553 920 1080 324 3627 6348 6351 PMC6078642__F7 Enzymes necessary for local aldosterone synthesis are present in muscle-derived leukocytes 6770 1583 1585 1584 PMC6082930__F3 Smurf2 as an oncogene 3845 1956 64750 2932 1499 PMC6090955__F1 Overview of the IDO metabolic pathway 169355 3620 3398 8564 PMC6096407__F2 Several lncRNAs bind to specific combinations of regulatory proteins, potentially acting as scaffold elements within ribonucleoprotein complexes, stabilizing their targets (e.g 100270680 8313 1499 2932 3190 1021 6925 PMC6096407__F4 LncRNAs can regulate gene expression by participating in chromatin looping (e.g 430 1499 6925 PMC6096407__F5 Several lncRNAs work at the post-transcriptional level as competing endogenous RNAs for microRNAs, titrating microRNA effector complexes away from their mRNA targets (e.g 283460 407040 23411 PMC6102727__F7 Schematic overview of LATS1/YAP/RHAMM pathway and the regulatory effects of LATS1 in the LATS1/YAP/RHAMM pathway 9113 688 2475 PMC6107850__F1 Overview of RNA-sensing pathway 1656 7098 170506 57506 55601 9188 1653 29110 3661 3665 1665 114548 10010 PMC6116077__F3 Interferon pathway 3458 7297 3716 3717 6773 6772 10379 PMC6121264__F6 Putative targets of down-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer and (B) PI3K-Akt pathway 2885 4609 1956 1499 5879 1495 6009 PMC6125308__F2 c-Met/INSR crosstalk in hepatocytes 3082 3667 3643 PMC6130388__F6 Schematic of proposed model 3553 406 9575 3603 PMC6135718__F6 Potential lymphangiogenesis therapies: learning from current anti-angiogenesis therapies - A review 1956 2064 2475 PMC6135780__F1 Extracellular signalling roles of S1P 388931 124976 8178 PMC6136085__F2 Persistent infections through defective viral genome immunostimulation 7185 7124 57506 PMC6142689__F3 Pathway of calcium signaling predicted by IPA 1356 7170 4772 79885 PMC6170398__F2 Central role of hepcidin in regulation of iron metabolism 6774 3569 151176 PMC6170679__F7 Model summarizing the proposed signaling events in the myeloid CXCR4 deletion mice 355 170 7852 3458 PMC6173124__F1 Role and regulation of host microRNAs in hepatic schistosomiasis 6772 6774 4092 7421 90865 PMC6179272__F6 Hippo signaling pathway in Duchenne muscular dystrophy 55432 83737 9113 26524 PMC6198989__F6 Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk 6943 4088 7046 7048 80310 1030 5156 25802 5159 1909 5155 9037 7291 PMC6203794__F1 Tumor-induced CD8+ Treg cells and their potential role in tumor microenvironment 1493 50943 940 920 PMC6205166__F9 Cachexia-inducing ability of 85As2 cells 7100 3654 3976 PMC6207572__F1 Dual functions of IFITM3 in the innate antiviral immune response 6772 6773 10410 3661 PMC6207598__F2 Toll-like receptors (TLRs) and their role in the evasion of the immune response induced by hMPV 4615 7189 7099 7098 51284 54106 PMC6211728__F7 Phenethyl isothiocyanate activates leptin signaling and decreases food intake 3717 5443 181 4852 PMC6215844__F2 Iron and inflammatory signaling to hepcidin 650 654 7018 148738 3716 3717 7036 6774 4086 4089 57817 3077 164656 4090 PMC6215866__F1 Mouse breast carcinogenesis induced by the activation of the canonical Wnt pathway 4040 4041 2932 1499 4609 PMC6215866__F2 Positive feedback loop between the Rspo/Lgr5 pathway and the Wnt/B‐catenin pathway 8549 4040 4041 54894 1499 PMC6215866__F3 Transforming growth factor‐beta pathway and the Wnt/Beta‐catenin pathway 4040 4041 1499 4087 4088 PMC6256083__F5 Proposed anti-inflammatory pathway of beauvericin (BEA) in macrophages (adapted from Yoo et al., ) 7099 4615 6850 6714 3553 PMC6260991__F7 Schematic representation for hypothetical M2 macrophage-induced myofibroblast differentiation of LR-MSCs 7476 8321 1499 PMC6262249__F2 Role of macrophages in hepatitis C virus infection-associated inflammation 7097 7096 51311 51284 114548 4615 3553 3569 PMC6262272__F7a Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1 9780 4040 1499 PMC6266917__F3 Systemic effects of increased adiposity on EC progression 284 3553 3976 3977 3479 PMC6274944__F1 Schematic representation of the extracellular matrix (ECM) components implicated in the regulation of c-MET signaling 3082 1950 1956 PMC6280650__F1 Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches 115004 978 29110 3661 PMC6284771__F8 Schematic model illustrating that miR-10b mediated function in osteogenic and adipogenic differentiation of hADSCs 4087 4088 4089 4092 860 PMC6287148__F1 Mitogen-activated protein kinase pathway 2885 3845 1956 673 PMC6287190__F1 Classic and alternative pathways of bile acids synthesis 1593 1582 9420 570 PMC6290461__F1 Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases 10269 2475 3569 PMC6290938__F10 Proposed mechanisms by which Adam8 deficiency in leukocytes and/or lung parenchymal cells leads to exaggerated cigarette smoke (CS)-induced chronic obstructive pulmonary disease in mice 101 1956 3553 260431 PMC6292222__F3 T cell differentiation 324 3560 1236 PMC6295097__F7 Proposed pathway of anti-tumor effects of propofol on lung cancer A549 cells 1499 442917 2475 PMC6298946__F1 IL-20 receptor cytokines and their receptors 11009 29949 58985 53833 PMC6300500__F1 Models for antigen cross-presentation mechanisms induced by adjuvants in DCs 7099 4615 8773 83871 PMC6304368__F7 Anti-HBV mechanism of TLR3 signaling of HSCs 3665 3661 3455 6773 6774 10379 7297 7098 471 PMC6307803__F6 The model of miR‐520b regulating NSCLC tumourigenesis 8405 2736 2737 PMC6312894__F1 From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis 7099 6364 1235 149233 PMC6317263__F2 Milk exosomes and allergy prevention 8651 1786 50943 4090 920 3702 3558 PMC6318427__F2 Current model of iron sensing in the liver to regulate hepcidin production 654 148738 7036 3077 5045 PMC6321995__F2 Therapeutic strategy for downregulation of excess inflammatory mucus to normal physiological mucus levels, using a small-molecule kinase inhibitor of MAPK13 1179 4586 5603 6778 324 PMC6325590__F6 Leptin signaling modulates appetite through primary cilia 5443 181 3953 6774 4160 109 PMC6328617__F2 CD44v6 engages in colorectal cancer progression 960 3265 4313 6387 6352 PMC6332930__F2 Interferon (IFN)-dependent IFN stimulated gene (ISG) transcription through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling 163702 3454 3459 3455 3716 7297 3460 3717 6773 6772 3660 3663 3394 3665 PMC6335330__F1 Epigenetic regulation at the RUNX3 AS-associated locus 8320 3575 864 3662 PMC6338329__F7 Mechanisms for human cervical epithelial cells (HCEs)-mediated HIV suppression in macrophage 3454 3455 7297 7098 6772 6774 10379 6773 3661 3665 6778 4939 9636 4938 PMC6347506__F5 Integrative regulation of physiology by histone deacetylase 3 8841 10716 6774 2874 79718 6907 4929 7018 2309 4204 5091 PMC6349817__F2 Crosstalk between the PI3K-Akt-mTOR pathway and the Hippo-Yap pathway via SIK2 23235 3481 51421 PMC6363996__F7 Model summarizing the inhibition of the cGAS-STING pathway by MDV VP23 115004 29110 3665 PMC6364034__F9 Working model illustrating that KSHV hijacks the citrulline-NO cycle to promote KSHV-induced cell proliferation and cellular transformation 445 6651 435 PMC6367542__F6 Proposed mechanisms of adiponectin-induced growth inhibition of pancreatic cancer 9370 51094 79602 2932 1499 6934 PMC6367546__F8 Schematic illustrating that CD9/ADAM17 axis plays a key role in keratinocyte migration via activation of EGFR/ERK signaling pathway 6868 1956 1839 928 1950 PMC6370266__F1 LPS-TLR4 activates the NFKB signaling pathway 4615 7189 4703 7124 7099 3553 PMC6370374__F6 Molecular mechanism underlying LINC01133 regulated pancreatic cancer progression 7471 2932 1499 22943 2146 PMC6376477__F11 Molecular mechanism of circHMGCS1: regulating miR-503-5p to control IGF signaling by functioning as a ceRNA 3481 2744 3480 PMC6377309__F1 SAMHD1 down-regulates the IFN-I pathway 23586 25939 115004 29110 3661 PMC6377309__F5 Role of SAMHD1 in the crosstalk between innate and adaptive immune responses 324 920 25939 PMC6381377__F6 Deregulated Wnt signaling pathways in the BM of ENU induced experimental leukemic mice 89780 7474 1000 22943 4920 1499 595 PMC6381446__F2 Schematic representation of the role of oxysterols in the Hh signalling pathway 6469 5727 6608 PMC6381934__F1 Metabolic pathways of 1,25(OH)2D and 27HC synthesis 120227 1593 1594 1591 9420 PMC6385204__F7 Angiomotin-p130 inhibits Beta-catenin stability by competing with Axin for binding to tankyrase in breast cancer 8658 324 1499 2932 PMC6386927__F6 THD on a crosstalk in Fzd/GSK3B/Beta-catenin/P62 axis 324 2932 1499 6925 PMC6405391__F1 Energy imbalance leads to obesity 7038 7124 3569 PMC6407099__F4 Role of Itch in Type I non-canonical Hh pathway 83737 6608 5727 1283 PMC6407676__F10 TGFB inducible epithelial-to-mesenchymal transition in renal cell carcinoma 4313 7048 7046 4087 4088 4089 PMC6412533__F10 Gemcitabine pathway extracted from PharmGkb database 2030 3177 9154 64078 978 1635 6241 6240 51727 PMC6415285__F2 Statins on several pathways involved in bone metabolism 6347 650 4088 PMC6429018__F8 Knockdown of PCAT-1 inhibited cell proliferation, metastasis, and promoted cell apoptosis in ECC cell lines 7471 1499 2932 PMC6434857__F2 Possible therapeutic implications of resveratrol/metformin/exercise in cognition through osteocalcin signalling 23411 57512 627 PMC6437095__F2 Interaction between miRNAs and TGFB pathway in GC 2638 4092 4087 4088 4015 2492 407009 PMC6437932__F8 Working model 79068 9589 664 PMC6439804__F1 Hedgehog-Induced Osteogenesis 6295 6608 2736 2737 9242 PMC6454697__F5 The relationship between zinc finger proteins and hippo pathway in cancers 7593 6935 25792 PMC6457262__F1 Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer’s disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity 8564 130013 23475 PMC6466002__F2 Duck RIG-I-like receptor (RLR) family signaling pathway 7706 8638 57506 3665 PMC6467053__F2 Signal Transduction pathway for STAT3 2056 3716 3717 6774 6772 PMC6480582__F7 Graphic summary for nifedipine-induced lipogenesis on renal tubular cell 4693 948 3156 2180 5465 PMC6496801__F4 The primary molecular pathways leading to pyroptosis in monocytes/macrophages in CVDs 948 114548 79792 PMC6497758__F3 Proposed Schematic diagram of the interaction of Mda5 with LGP2 in the RLR signaling pathway 29110 3665 3661 57506 PMC6506535__F5 Natural killer cell signaling pathway of MAIT cells in comparison with conventional T cells 3932 7535 27040 2885 PMC6510543__F1 A sugar rush for innate immunity 80216 92610 7189 PMC6522871__F2 Small molecule inhibitors and the ALK-Smad signaling pathway 4087 4088 4089 PMC6522942__F1 Cell surface and endosomal signaling pathway of TLRs 7096 7097 7100 7099 4615 7189 51311 51284 3665 3661 54106 7187 3725 2353 7098 PMC6523794__F4 PPI network for the upregulated genes in the AMPK signaling pathway 5518 3991 51094 6517 79602 1375 1374 948 2309 10645 PMC6525564__F4 Adrenal C19 steroid pathway 3284 1528 6770 1583 1586 1584 3291 8644 PMC6527835__F1 Schematic illustration of the mammalian ganglioside synthesis pathway 7357 9334 8869 2583 8708 6483 2760 3073 3074 PMC6536409__F7 LncRNA TNRC6C‐AS1 facilitated cell proliferation and inhibits cell apoptosis and autophagy by promoting the methylation of STK4 promoter region via the Hippo signalling pathway 9113 26524 1786 1789 6789 PMC6539579__F3 Regulation of Wnt/Beta-catenin/c-Myc signaling pathway 324 1499 6925 595 PMC6549079__F5 Signaling pathways related to RUNX3 6925 1499 4089 9759 6046 4088 864 PMC6554024__F4 Decoding type I and III interferon signalling during viral infection 115004 23586 4615 29110 3665 3661 57506 7098 51284 PMC6554024__F5 Decoding type I and III interferon signalling during viral infection 7297 3716 6772 10379 6773 PMC6557020__F2 Mechanisms of the SLIT/ROBO pathway as an oncogene in cancer 9353 407021 2932 1499 64221 6092 PMC6559935__F1 Leptin and leptin receptor activation pathway 3717 9021 6774 PMC6562376__F3 B3/KRAS/RalB/NFkB pathway mediates EGFR-targeted therapy resistance 1950 1956 3845 5899 PMC6571119__F4 ASD causal genes affecting BMP signaling and potential crosstalk with other signaling pathways 6469 54413 2332 7337 PMC6585541__F1 Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar? 920 7852 114548 23581 PMC6587274__F5 Summary of STAT3-FOXL2 signaling function in HeLa cell growth and apoptosis 6774 668 7124 2798 PMC6589170__F1 NLRP3 inflammasome pathway 7099 4615 114548 3603 PMC6589702__F8 Proposed model of regulation of endothelial barrier function by FBXW7 55294 3949 388 3156 6713 PMC6590351__F4 Potential therapeutic target proposed to block leukaemia properties induced by the presence of CBFA2T3‐GLIS2 84662 863 6790 PMC6594827__F2 Other fatty acid metabolism targets 2194 11343 9314 51 1374 5465 619501 PMC6602950__F6 The rheostat model proposed for Notch signaling network 2033 3717 6774 3516 PMC6605697__F7 Possible antifibrotic mechanism of exogenous hydrogen sulfide in diabetic cardiomyocytes 2932 1499 4088 PMC6610579__F5 The schematic image of HBx/AKT/FOXO1 signaling pathway and AA metabolism induced inflammation 239 1499 4050 4048 PMC6612360__F1 Endothelial dysfunction and angiogenesis impairment in the ageing vasculature 57097 23411 2475 3479 PMC6615683__F6 Model describing the putative mechanism of synergetic interaction between PFK158 and erlotinib in WT and mutEGFR NSCLC cell lines 1956 5209 1385 PMC6621796__F11 Schematic drawing to illustrate JAK-STAT signaling pathway 10379 2670 4170 PMC6624737__F1 Simplified demonstration of decarboxylation events with associated position-specific isotopomers used in this study 717 718 5091 PMC6627901__F5 Model for the oncogenic activation of the EGFR signaling pathway and response to therapeutic EGFR-blockade in basal HNSCC 2069 374 1956 PMC6628048__F1 Synthesis of bile acids (BA) 10858 1593 1581 9420 1582 PMC6628899__F1 Ipilimumab in prostate cancer 940 1493 324 PMC6635658__F7 Schematic model depicting the possible mechanisms of nobiletin-mediated inhibition of renal cancer cell proliferation 6714 6774 55249 PMC6636202__F8 Illustration of the miR-153 gene pathway in bladder cancer cells 3569 3570 6774 3620 PMC6642871__F2 The glycolytic switch in different cell types 5209 2475 2539 PMC6643298__F9 The conclusion of the results in this study 5091 56994 6609 PMC6646053__F1 Antibody mediated complement activation 7448 966 1604 4179 1378 PMC6650359__F6 Proposed pathway for the role of OLA1 in ANG II-induced cardiac hypertrophy 2932 1499 4878 4625 PMC6651805__F6 Schematic diagram summarizes the mechanism whereby CCN3 promotes Runx2 and osterix expression in osteoblasts 4856 693193 860 PMC6657652__F2 Contrast inflammatory signals in human gingival fibroblasts triggered by the different acylation structures of P 3929 929 7099 7097 PMC6662984__F1 A2-3-sialyllactose showing PDB numbering 729 727 720 PMC6664754__F2 Proposed model of the Lgr5-mediated stimulation of cancer growth through activation of the Wnt/Beta-catenin signaling pathway 4040 4041 8549 1499 595 PMC6665304__F4 DISC1 regulates neurogenesis via Wnt/Beta-catenin signaling 27185 2932 1499 PMC6668978__F10 Schematic diagram shows the interplay of TGFB1, Notch, Shh signalling and Foxa in antler chondrocyte proliferation and differentiation 7040 6469 6608 4853 4851 4088 PMC6679057__F2 WNT pathway molecules and their involvement in chemoresistance in NB 8323 8321 1499 144165 57216 PMC6679985__F3 Circadian Clocks and Cancer: Time-Keeping Governs Cellular Metabolism 6945 4609 9575 406 PMC6684366__F2 Biosynthetic pathway of VLC-PUFAs in the mammalian retina 60481 54898 64834 83401 6785 PMC6685213__F4 Kaposi Sarcoma 7097 7099 115004 7098 51311 51284 3603 57506 54106 7189 7187 29110 4615 3661 3665 PMC6686482__F7 Schema presented the mechanism through which NOTCH1 aerobic glycolysis and signaling in PC cells were modulated by MACC1-AS1 100874041 7849 4851 4318 PMC6703304__F1 Interferon receptors and signalling 56832 338376 3458 3454 3455 3459 3460 3716 7297 3717 6772 6773 PMC6703648__F7 Proposed model for the role of the Rb/E2F pathway in the coordination of proliferation and differentiation during neurogenesis 1746 144455 1745 PMC6710443__F10 Schematic diagram of the mechanisms about the role of HDAC3/NF-kappaB pathway in pathogenesis and exercise therapy of OA 8841 11096 3553 PMC6723883__F4 model of CFHR1-3 participation in Andes orthohantavirus (ANDV) infection response 10326 10878 3078 727 PMC6726833__F7 Functional roles of SALL4 in cervical cancer cells 2932 8312 324 1499 595 57167 4040 4041 PMC6728679__F5 Sketch map of the Wnt5a/Ror2 signaling pathway in bone marrow stromal cells (BMSCs) that derives osteoclast precursor migration and differentiation 7852 7474 4920 6387 PMC6731416__F9 Proposed model for the roles of Wnt/Beta-catenin signaling regulated by quercetin in protection of BBB breakdown 2932 1499 51176 PMC6738402__F1 Role of Fyn in misfolded Alpha-synuclein (ASyn)-mediated NLRP3 inflammasome activation 948 2534 114548 PMC6757184__F1 Wnt/Beta-catenin signaling as a useful therapeutic target in hepatoblastoma 1499 2274 2932 1950 81539 PMC6757296__F2 Exosomes secreted by MM, NSCLC and PCa tumors carry different and abundant contents, which serve a key role in osteoclasts or osteoblasts, resulting in different metastatic lesions 374 2113 1956 PMC6763723__F1 VLC-SFA and VLC-PUFA elongation pathways 79071 60481 54898 83401 79993 64834 6785 PMC6783260__F1 Complement activation triggers neuronal damage 920 4803 718 PMC6785663__F1 Classic view on the pathogenesis of celiac disease 3600 324 920 8178 PMC6801436__F2 JAK1-TYK2 heterodimer signaling pathway 3458 3716 3717 7297 6772 6773 PMC6803322__F8 Diagram illustrating the IL-6 signaling pathway triggered by the binding of IL-6 and its receptor complex resulting in JAK2/STAT3 activation 9021 3717 6774 PMC6814598__F1 Damaged nuclear DNA export, sensing and clearance in aging-related inflammation 115004 29110 3661 PMC6815315__F3 GSK3 regulates cell death, renewal, and differentiation 3479 3667 324 1499 4170 PMC6816394__F5 Role of tPA in the proliferative signaling and Wnt/Beta-catenin signaling 2932 1499 595 PMC6820523__F9 Our proposed model of nsDNA-induced APOL1 expression through engagement of the cGAS/IFI16-STING pathway in human immortalized AB8/13 podocytes 3661 29110 8542 7297 3716 6772 115004 3428 PMC6821213__F8 FAE therapy modifies the metabolic-epigenetic interplay in multiple sclerosis to reduce pathogenic CCR6+ CD4 and CD8 T cells 406991 4092 1235 PMC6826992__F9 Models of EGFR-ligand dependent pathway and EGFR-ligand independent pathway in EIS cells 1956 6714 2065 PMC6827018__F8 Schematic representation of the entire signaling pathway 2296 7018 26524 PMC6829404__F8 Leptin-induced EMT via Src and FAK signaling pathways 1950 3717 1956 6714 1499 PMC6829565__F6 Schematic diagram depicting the MAPK/ELK1 signaling pathway linking Ang II-RBM20-titin splicing 367 2002 282996 7273 PMC6830079__F3 Two faces of cGAS-STING signaling in cancer 115004 324 6772 6774 3627 7124 6347 PMC6844216__F1 Different death mechanisms of liver cells are involved in the pathogenesis of liver injury induced by MNPs 2475 79792 8717 PMC6844630__F1 Mechanisms of action of miR-21 showing the regulation of the WNT signaling pathway in NAFLD mice 4040 2932 1499 PMC6849114__F6 De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry 4851 10309 345643 2302 344022 PMC6850109__F1 Pathogenesis of antibody‐mediated rejection and potential therapeutic targets 952 958 1356 727 3416 PMC6851267__F8 Ghrelin attenuates neuroinflammation and demyelination in EAE involving the NLRP3 inflammasome signaling pathway and pyroptosis 79792 3553 114548 PMC6851586__F1 Pathways in the pathogenesis of PSO 1672 1673 6278 2920 3576 6374 2919 2921 1667 6364 3107 6774 3868 3553 4283 3627 6373 5132 PMC6854696__F5 Schematic diagram of miR-889 regulates osteoblastic differentiation of hBMMSCs by targeting WNT7A and through Wnt Beta-catenin signaling pathway 4040 4041 1499 7476 PMC6854717__F6 Mechanism scheme uncovers that CRISPR/Cas9-mediated knockout of NSD1 promotes H3K27me3 methylation and inhibits Wnt10b transcription, thereby suppressing activation of the Wnt/Beta-catenin signaling pathway 64324 7480 1499 PMC6855070__F2 Molecular pathway signaling of angiogenesis-induced epithelial-mesenchymal transition in hepatocellular carcinoma 7040 619501 7422 406971 3082 PMC6856883__F3 The regulatory roles of lncRNAs in TAM by regulating classic signaling pathway 139728 7189 4313 PMC6862063__F12 Schematic summary of IL-6 induced effects on the JAK-STAT pathway and its main regulator, SOCS 3569 3716 3717 8651 9021 6774 3570 PMC6862352__F1 Hh in the ischemic skeletal muscle 6469 50846 3549 PMC6868871__F6 Summary diagram demonstrating the contribution of IGF-1/IGFBP to transcriptional levels of PPARG, VEGF, and HIF-1A under the administration of BV intervention 3484 3486 3479 PMC6874533__F9 Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells 1499 3207 85407 595 1786 221883 PMC6880832__F7 Schematic illustration of miR-4666-3p and miR-329 are both low expressed in non-QCCSCs and synergistically regulate TGFB/Smad pathway 4087 7046 4088 4089 PMC6886858__F6 A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus 130589 9601 375287 3665 3717 6772 10170 3659 352961 55106 6773 554282 PMC6889937__F5 Proposed action pathway through which Hnk protects cardio-myocytes against Dox-induced senescence 10628 114548 3553 PMC6903413__F4 NFKB pathway in pancreatic acinar cells 885 3569 7124 1508 PMC6909968__F6 Proposed schematic model illustrating the role of SLCO4A1-AS1 in regulating CRC by EGFR/MAPK signaling pathway 1956 3845 673 100127888 4214 PMC6910186__F8 Roles of miR-21 and the PDCD4/c-Jun signalling pathway in renal cell carcinoma 4313 27250 4318 7422 PMC6916499__F1 Retinoid transport and transformations in vision 9227 6121 5959 PMC6923371__F3 Schematic illustration of a causal network in the Ingenuity Pathway Analysis (IPA) environment 7422 4316 3082 PMC6925091__F5 Necroptosis is an example of antagonistic pleiotropy 2475 8737 11035 81030 197259 PMC6928565__F1 Notch3 signalling and vascular remodelling in pulmonary arterial hypertension 182 3714 102 6868 3516 100188776 PMC6937732__F8 Schematic model depicting the promotion of esophageal squamous cell carcinoma (ESCC) cell metastasis 6714 2932 6774 PMC6940522__F5 Resveratrol downregulates miR-31 to promote T regulatory cells during prevention of TNBS-induced colitis 8651 4052 9021 PMC6954292__F1 Androgen metabolism in human prostate 3283 1646 1586 8644 3294 8630 PMC6959132__F4 Pathway for signaling from p75–Nogo receptor complex to RhoA 4099 84894 387 9475 PMC6960354__F1 Kynurenine pathway of tryptophan metabolism 3458 8942 8564 PMC6961090__F1 Epidermal growth factor receptor pathway and mechanism of action of osimertinib 7039 1950 3716 3717 6774 2475 PMC6978911__F8 Schematic comparison between CiTLR22a- and CiTLR22b-mediated signaling pathways 4615 11213 3665 3661 PMC6981023__F6 Graphic summary of the regulation of memory T cell response by mTOR and Stat3 940 6774 3091 9021 604 8320 PMC6984455__F1 Brief mechanisms of Ub-dependent and Ub-independent mitophagy 5071 664 665 23786 23770 55054 PMC6984792__F8 Mechanism of action of ASB in UV-induced photo-damage in HaCaT cells 9817 2729 3553 PMC6994936__F8 Proposed involvement of FGF9/FGFR2 signalling in human fetal gonad development 6736 6662 54361 2254 2263 PMC7007436__F7 Pten-mediated Gsk3B modulates the naïve pluripotency maintenance in embryonic stem cells 2475 5728 2932 PMC7010853__F8 Speculatively schematic diagram of this scientific hypothesis including the most significant SF (CLEF5), OS-SEs (GSG1L|35698|AP, GSG1L|35696|AP) and downstream pathway (Primary bile acid synthesis) 60680 146395 100188857 PMC7017369__F7 Signaling cascades of RA-mediated repression of B3GALT5-LTR promoter activity that reduce SSEA3 synthesis in human ES cells 23411 6774 10317 PMC7017935__F12 Antral follicle steroidogenesis 6770 3283 1588 3292 PMC7020065__F5 During pregnancy recognition (PR) in cattle conceptus produced IFNT increased expression of type I IFN-stimulated genes (ISGs) in the uterine endometrium and increased prostaglandin (PG) production facilitates these effects 3458 3454 3455 3459 3717 7297 3716 7098 51311 51284 64135 6772 6773 7187 3661 3665 5021 5742 5731 5737 5743 5732 5733 5734 PMC7022340__F6 Working model of the roles of Beta-catenin and US3 in the DNA-sensing signaling pathway 115004 324 2932 29110 1499 3661 PMC7023707__F1 Kynurenine pathway and tryptophan metabolism in the central nervous system 8942 8564 23475 PMC7033608__F3 Possible mechanism of Wilms tumor 1 antisense RNA (WT1-AS) functioning 51352 7490 3344 PMC7037748__F1 Wnt/Beta-catenin signaling pathway, which is inactive in the absence of Wnt ligands (OFF) and active upon binding of Wnt ligands (ON) 4040 4041 51527 324 1499 607 PMC7037748__F2 Regulation of the Wnt/Beta-catenin signaling pathway when it is inactive (OFF) and when it is active (ON) 54894 84133 22943 147495 50964 4040 4041 55366 8549 1499 PMC7063521__F1 Positive and negative regulators of hepcidin synthesis 650 654 7036 3077 148738 4089 151176 6774 164656 PMC7070911__F1 Metabolic pathway and mechanism of action of Clopidogrel 1557 1555 64805 PMC7071121__F6 Proposed mechanism for RPG in regulating the uterine involution in post-natal dairy cows 3479 3481 3480 3482 2475 PMC7071696__F7 Mechanism graph of the regulatory network of miR-495/HOXC6/TGFB in the progression of OSCC 3223 4089 7046 PMC7072930__F2 Therapy for fibrodysplasia ossificans progressive (FOP) 5168 2475 4089 4090 4086 PMC7073129__F2 Schematic demonstration of the inhibition of the RAR pathway by BMS 619537 7482 4041 PMC7076221__F8 Working model for protective effects of SIRT1 via HAS2–AS1 and NFKB 3037 1690 23411 594842 PMC7080653__F1 T1DM candidate genes acting at the beta-cell level mainly play a role in three pathways (): (1) Regulate the innate immune response and pathways important for antiviral activity, such as the type 1 IFN signaling pathway (IFIH1, TYK2, PTPN2) 7297 3716 5771 60468 1512 7128 6810 6772 10379 169792 2065 23274 PMC7093169__F2 Molecular mechanisms driving renal fibrosis are wide-ranging and complex, among which signaling pathways are very important 79602 26060 50507 PMC7116063__F1 Signal integration in the (m)TORC1 growth pathway 83667 652968 201163 6009 PMC7132142__F7 Schematic representation depicting the role of KMO in MM (a) pDCs trigger growth, survival, and drug resistance in MM cells 8564 5132 3620 8942 23498 PMC7145977__F4 Hypothetical model showing the possible role of Sirtuins and circadian system in the pathogenesis of diabetic lung 23411 51548 23410 2309 4088 PMC7147028__F8 Schematic diagram showing potential involvement of miR-761 inhibiting EMT in CRS mice through targeting LCN2 in the LCN2/Twist1 signaling pathway 100313892 3934 7291 1000 PMC7150840__F2 FGF23/Klotho interactions with the Wnt/Beta-catenin pathway in the bone, kidney, and heart 2260 1499 8074 PMC7150862__F8 Schematic model of miR-202-5p-mediated RIG-I-like receptors (RLRs) signaling pathway during viral infection 57506 7189 7187 7706 29110 3661 PMC7153214__F6 The mechanism 4088 3717 6774 PMC7157451__F2 IFNA and IFNB bind to the type I IFN receptor (IFNAR) and activate the expression of numerous ISGs via the JAK/STAT pathway 3669 103 3716 7297 3434 6772 6773 3661 3665 10379 PMC7171093__F7 Activation of STAT3 is a key event in TLR4 signaling-mediated melanoma progression 7099 6774 4615 PMC7175140__F3 TGFB/SMAD signaling pathway 4087 4088 4092 4089 7018 PMC7175615__F5 Pathway of TGFB2-TLR4 crosstalk within the glaucomatous TM 7042 7099 4615 25805 PMC7176421__F6 Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement 355 2475 627 PMC7184931__F3 cGAS-STING-IFN pathway activation in SLE 6573 11277 115004 PMC7193445__F2 Examples of SLC mediated drug transport across the blood-brain barrier and in glioblastomas and neurons 8140 6774 6584 PMC7193471__F8 Signaling model of the IL6R-ADAR1-STAT3 interplay in multiple myeloma 3569 3570 3717 6774 596 4170 PMC7201075__F1 Arachidonate-prostanoids pathway gene expression in colorectal cancer (CRC) tumors 5742 5743 6916 5740 10728 8644 5739 80142 9536 3248 5729 5737 5731 5734 5732 5733 PMC7202494__F7 Let-7f-5p/TARBP2 regulatory feedback loop in OS cells, which is induced by hypoxia and reduces the expression of let-7f-5p and TARBP2 in OS cells 6895 2932 1499 PMC7212460__F2 Canonical Wnt/Beta-catenin pathway 2932 324 1499 PMC7216262__F3 mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases 2475 1270 3479 1950 5728 PMC7218174__F3 Autophagic compensation in resistance to MET-targeted therapy 3082 2475 2744 8408 PMC7222031__F2 PVR’s role in immunomodulation 325 5819 5817 201633 10225 PMC7222158__F3 Gene network of regulation of synaptic transmission, glutamatergic (obtained using Pathway Studio v 2898 5743 6335 PMC7229901__F1 Treg-mediated suppression 374 941 942 201633 PMC7232267__F4 Fibroblast growth factor receptor 1 (FGFR1)–B klotho complex plays roles in endothelial homeostasis 9965 26291 152831 4088 2260 PMC7232345__F7 Proposed model for OAS2 regulation of ZIKV replication and IFN pathway 3665 6772 4939 6773 3661 10379 3433 PMC7235190__F5 Regulatory mechanism of HDAC2/3 on LPL expression in SH-SY5Y cells 8841 3066 4023 PMC7244030__F8 LOC646616/miR-637/WNT3 ceRNA network in EH 94032 693222 7473 1499 PMC7248261__F1 Pathophysiology of allergic contact dermatitis (ACD) 324 3553 3458 PMC7250673__F1 Bone Cell Communication Factors Provide a New Therapeutic Strategy for Osteoporosis 10371 6586 115908 10507 PMC7251178__F2 Inflammasome complex -dependent and -independent pathways involved in EMT 114548 4089 4087 4615 3606 4088 PMC7255470__F7 Schematic representation shows the potential mechanism of Sevo-mediated anti-proliferation and anti-invasion roles in hepatocellular carcinoma cells 5728 2932 1499 PMC7258707__F7 Potentiating immune response by activating TLR signaling pathways.With the exception of TLR3, all TLRs activate MyD88 dependent pathway which leads to NFKB mediated proinflammatory cytokine upregulation 7099 7097 929 4615 114609 7098 54106 51284 7189 29110 3661 PMC7267729__F5 Dysregulation of the Myostatin Pathway in Mtm1−/y MiceThe members of the myostatin pathway analyzed in this manuscript at the mRNA or protein levels are indicated in this figure 10220 4087 4088 2660 PMC7273913__F1 Characterization of FANCL variants observed in patient cancer cells 2177 55215 55120 29089 PMC7278993__F8 Schematic diagram showing the pathways involved in the pathogenesis of vascular calcification (VC) in chronic kidney disease (CKD) 6424 6425 89780 7474 1499 PMC7281956__F10 The ROS/PARP/TRPM2 signaling pathway that mediates SiNPs-induced pulmonary inflammation in mice 7226 8505 4280 2919 3576 8878 PMC7286374__F3 Primary pathway of steroidogenesis and enzyme inhibition by posaconazole (P) 6770 1583 1586 1589 1584 1585 PMC7291262__F2 MiRNAs/CD133 axis in glioblastoma signaling pathways 407046 4853 6469 5338 PMC7297493__F1 Schematic representation of the hypothesized downstream pathways to ASCL1 and MYT1L during transdifferentiation 429 23040 9757 PMC7310007__F2 cGAS-STING pathway 29110 3661 115004 PMC7311368__F1 Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy 3553 90865 6347 PMC7312833__F2 Canonical and non-canonical inflammasome pathways 114548 79792 3553 PMC7318076__F2 Representative strategies to optimize cytoplasmic signaling of CD28ζ CAR 652070 940 3560 6774 PMC7324512__F6 Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway 389136 9113 26524 51421 PMC7325303__F1 Apoptosis in health and disease: the balancing act of BCL-2 family proteins 596 4170 317 4609 331 572 8739 PMC7330432__F1 MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway 100616182 6241 5111 7077 PMC7330432__F10 MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway 100616182 6241 5111 7077 PMC7330533__F8 Schematic of anemoside B4’s anti-inflammatory mechanism 7099 4615 3603 PMC7333391__F5 Postulated mechanism by which CagA promotes the expression of IL-6 in gastric cancer 5008 6774 1915 9180 PMC7340996__F2 Structure of the filaments containing Septins 7/9b/11 and Jun N-terminal kinase signaling pathway 989 55752 10801 PMC7341381__F1 Structure of the Slit/Robo protein 64221 6092 6091 1499 PMC7343769__F1 Molecular mechanisms of chloroquine/hydroxychloroquine in pDCs 54106 51284 4615 115004 7124 3569 57506 941 942 PMC7347075__F1 Metabolic kynurenine (Kyn) conversion pathway 3620 8942 8564 130013 23475 PMC7352793__F6 ncRNAs involved in the IR-induced Wnt/Beta-catenin pathway 100124700 1499 56849 PMC7356105__F3 TNF pathway inhibition in HGF in response to C 7124 7186 85451 9261 2 PMC7356355__F1 Intoxification Pathway 1950 3558 2522 PMC7363309__F1 Utilizing cooled liquid chromatography and chemical derivatization to separate and quantify C3-epimers of 25-hydroxy vitamin D and low abundant 1A,25(OH)2D3: application in a pediatric population 1593 1594 1591 PMC7363763__F2 Endothelial cilium regulates various signaling pathways involved in the vascular barrier, such as HH and Notch pathways 51684 2736 2121 54567 5727 6469 4851 23432 6608 PMC7364497__F2 Crosstalk between key signal pathways during prostatic budding 4824 1499 367 PMC7369546__F3 ClueGO plug-in, in terms of biological process and biochemical pathway process annotations, revealed biological terms which were associated with the 7 hub-bottlenecks (see ) 4318 3569 2919 PMC7369546__F4 ClueGO plug-in, in terms of biological process and biochemical pathway process annotations, revealed biological terms which were associated with the 7 hub-bottlenecks (see ) 4318 7124 3586 3569 2920 2919 PMC7370863__F1 VG9/VD2 T‐cell response to microbial antigens and self‐phosphoantigens—the little things that give it away 3652 11120 10385 11119 11118 PMC7373899__F2 Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction 9021 11274 8651 3660 PMC7374824__F1 TLR signaling 7097 7096 10333 7100 7099 7098 54106 51311 51284 3661 3665 4615 114609 PMC7376987__F2 Summary of recent advancement toward heart regeneration 7852 6387 5308 PMC7378193__F7 Regulatory network of MYO18B mRNA that reflect the survival outcome in hepatocellular carcinoma 84700 3429 1051 4636 3458 4430 PMC7378533__F2 Type I IFN due to the activation of IFN receptors 3716 7297 3717 6772 6774 6773 PMC7379337__F7 Schematic illustrating the mechanisms involved in the protection of hyperoside against oxidative liver stress 23035 2932 2534 PMC7390515__F2 TGFB signaling in health and disease 4087 4088 4089 4092 PMC7409324__F3 Interferon (IFN)-induced expression of MHC-I 3458 3460 3454 3459 3455 3717 7297 3716 6774 6773 3659 PMC7417311__F6 Current Sarcoidosis Models and the Importance of Focusing on the Granuloma 6955 3725 3550 8784 PMC7424765__F1 Postulated targets of action of B2-adrenergic agonists in DOK7 patients 4038 4593 285489 PMC7425451__F5 Downregulation of miR-135a on RAB1B and the RAS signaling pathway in NSCLC cell progression 81876 5879 5894 387 PMC7430807__F2 Metabocentric view of cardiac remodeling 1051 163732 2475 PMC7432002__F3 Interaction among MyD88, Toll-like receptor 4, IL-1 receptor signalling pathway in the innate immune response to tick-borne pathogens that could positively control the IFNG secretion; meanwhile, there is lack of IL-18 and IL-12 due to MAS 51135 3656 6777 7099 3552 4615 3717 3606 8651 3458 3592 PMC7432002__F4 Interaction between MyD88 and JAK-STAT pathway, linked to IFNA; this interaction is mediated by suppressors of cytokine signalling 3, SOCS family proteins which are part of a classical negative feedback system regulating cytokine signal transduction 3445 3446 3449 3451 3443 3440 3718 9021 3444 3717 3452 3439 4615 3656 51135 PMC7434656__F2 Interactions of TGFB and RAAS signaling 4087 4088 4089 1490 PMC7457738__F8 Proposed schematic representation for GAST in GC development and progression 2520 6714 6774 4320 PMC7461995__F1 Pseudomonas aeruginosa Can Degrade Interferon λ, Thereby Repressing the Antiviral Response of Bronchial Epithelial Cells 4599 4938 3716 10379 7297 6773 3659 3661 3665 PMC7464740__F1 General model for the Wnt/Beta-catenin signaling pathway and its regulation by the destruction complex 4040 324 2932 1499 PMC7466447__F1 Immunoregulatory functions of TEC in the TME 920 115004 3458 51162 2247 7006 100124696 3627 PMC7468582__F9 WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation 3717 6774 9948 PMC7471374__F3 Maturation of DCs and IL-1A/B mediated by CARD9 6850 8915 114548 3554 PMC7472841__F3 RIG-I-like receptors (RLRs) antiviral signaling pathway 57506 7186 7189 7187 29110 3661 3665 PMC7484670__F6 MTOR-miR-143 signaling axis in the pathogenesis of AD 3597 2312 3713 PMC7485269__F1 General organization and function of mammalian neuromuscular junction (NMJ) 43 4038 4593 PMC7485276__F2 Illustration of selective components in the BMP signaling pathway, important for bone and cartilage formation and fracture healing 4090 4086 4089 PMC7486640__F5 One of the possible mechanisms of MFSD to alleviate the damage of high glucose to podocytes 4040 4041 1499 6925 PMC7488916__F6 Working model for amplified cross-talk between CXCR4 and EGFR to promote gastric cancer metastasis 6387 1950 7852 1956 PMC7503332__F2 Schematic signaling pathway of TLR7 and 9 54106 51284 4615 51135 3654 3665 PMC7508496__F2 BMP 7/Signaling Antagonizes TGFB−Induced Organ Fibrosis: MechanismBMP-7 and TGFB1 bind to distinct type II receptors that form complexes of specific type I serine-threonine kinase receptors 4087 4088 4090 4086 7018 PMC7509264__F1 Resolution of inflammation in immune and nonimmune cells by interleukin-19 6774 29949 53832 53833 PMC7518857__F6 INPP5E regulates Hedgehog signalling via ciliary phosphoinositide metabolism 56623 23432 6608 PMC7522025__F1 Schematics of spiralian embryo, TGFB superfamily cassette and larval Capitella phenotypes 4838 4090 4086 PMC7523359__F7 Roles and locations of CCND2 and CTNNB1 in Hippo signaling pathway and HPV infection pathway 2932 1499 894 PMC7530064__F9 Diagram of signaling pathway of IQGAP1 in regulation of VEGFR2-Src-Rac1 activation in choroidal angiogenesis 6714 7410 5879 8826 PMC7532081__F6 Diagram illustrates the hypothesis that TP53INP2 modulates cell migration, invasion, and EMT via the GSK-3B/Beta-catenin/Snail1 pathway in bladder cancer.Abbreviation: EMT, epithelial-to-mesenchymal transition 58476 2932 1499 PMC7532258__F8 HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3B/Beta-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats 4040 2932 1499 PMC7534289__F1 Two-Signal Models of Costimulatory and Inhibitory Pathways 942 941 940 PMC7538694__F7 BMP signaling pathway in mouse and zebrafish 4090 4086 4089 3397 PMC7540151__F2 Apoptosis by miR-187 1545 604 1400 596 2254 80381 27123 1499 8313 51176 PMC7541692__F1 Dysregulation of the mitogen-activated protein kinase (MAPK) signaling pathway in melanoma 4763 673 4893 PMC7542480__F4 Protein-protein interaction network 5467 6256 8505 5320 1557 7498 2944 3290 25824 7124 5170 PMC7544984__F6 Crosstalk between SRSF3 and other splicing regulators in the regulation of gene expression 6428 6426 3191 PMC7550420__F1 Diagram of STING-mediated immune response to viruses 115004 29110 3661 PMC7550584__F3 Schematic pathway for DEP-mediated olfactory dysfunction 79846 56603 132204 3553 3569 PMC7552066__F4 JAK/STAT signalling pathway 1956 3717 3716 3718 7297 7084 6774 6772 6773 6775 6776 6778 10379 PMC7552066__F6 HPV modulation of the STAT3 signalling pathway 1956 3716 3717 7297 3718 6774 5879 406910 PMC7552066__F7 HPV modulation of the STAT5 signalling pathway 2056 3563 1956 3716 3717 3718 7297 6776 51621 23024 55294 PMC7554785__F3 Reduced TCF1 expression promoting a differentiation bias of activated aged T cells toward terminal effector cells 864 3559 2475 51176 604 PMC7556029__F3 Molecular mechanisms of IL-36R induced tissue fibrosis 6347 2919 3458 4615 114548 PMC7566413__F2 Regulatory Function of CCR9+ Dendritic Cells in Inflammation and Autoimmunity 50943 920 6370 10803 PMC7568159__F2 MyD88 and IRAK-4-mediated signaling pathway 7096 7097 7100 10333 81793 7099 7098 51311 54106 51284 4615 51135 PMC7568806__F5 Top network identified by ingenuity pathway analysis 259266 1058 7621 64699 23446 306 PMC7582904__F2 Mechanisms for restoring HLA class I expression 1950 3466 6772 673 1956 PMC7586430__F3 Regulation and functions of NEDD4 E3 ligases in vascular disease 7040 650 64750 11060 7049 57154 5414 860 PMC7591521__F6 CsIVa-mediated inhibition of miR-155/GSK-3Beta-NFKB signaling pathway 7099 929 2932 3553 PMC7594413__F2 The MAPK pathway is here shown 2885 673 2932 PMC7599984__F1 Wnt signaling pathway 4040 4041 2932 PMC7602033__F2 Cardiac remodeling by microRNAs and the functions of their target mRNAs 6774 5728 5894 4092 PMC7606590__F1 Intracellular model of GH signaling under normal and pathological conditions in Human adipocytes: 3717 6714 50486 4023 PMC7608746__F1 SPRED proteins and their roles in signal transduction, development, and malignancy 2885 161742 2115 PMC7610307__F3 GSK 3B regulates the key signaling proteins of the Wnt pathway 2932 324 1499 595 4040 4041 PMC7641541__F3 Schematic graph showing that the complement system participates in the development of alcohol-induced liver disease 27202 718 1571 7099 PMC7642368__F5 Airway neutrophils are activated in intubated children with compared to children without PARDS 1903 967 4353 PMC7650809__F1 CTLA-4 pathway: (A) T cell activation in response to the tumor-associated antigen requires 2 signals 941 942 940 PMC7655196__F1 Summary scheme of MerTK-mediated macrophage HSC crosstalk pathway in fibrotic NASH 6868 2621 10461 7040 PMC7655915__F7 Proposed model of the stimulatory effect of growth differentiation factor 8 (GDF8) on relative transwell cells in human trophoblast cells 10272 4087 4088 4089 PMC7663396__F1 Signaling pathways leading to signal transducer and activator of transcription 3 (STAT3) activation 1956 3716 6714 2475 PMC7672621__F9 Schematic regulatory pathway of linagliptin in OSI-906-induced hepatic steatosis 3479 3480 4837 PMC7675406__F3 Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 6347 7450 3383 3384 729230 PMC7676208__F7 Potential mechanisms of inflammation by COLEC12 mediated through TLR4 in osteosarcoma 81035 4353 7099 718 3606 PMC7676916__F10 MiR-204-mediated regulatory mechanism in chicken granulosa cell (GC) proliferation, apoptosis, and autophagy 80036 2475 8408 3607 PMC7677583__F1 JAK inhibition and immune regulation by the JAK pathway 2057 5618 2690 3575 3566 50615 149233 7297 3717 3716 3718 PMC7684877__F6 Putative mechanism by which metabolite secretions of L 7422 4313 4318 PMC7687355__F3 Predicted activation of HGF signaling after both APAP300 and PHX 221395 51053 3161 9319 3082 3397 1958 8431 57007 PMC7695496__F2 Regulation of CH25H expression 7099 3466 3661 9023 9314 467 PMC7705326__F1 Mechanism of action of possible anti-SARS-CoV-2 drugs on the interferon signaling pathway 3458 7297 3716 3717 6772 6773 6775 2475 7098 54106 4170 3665 4615 10379 6774 7187 3659 29110 3661 PMC7708667__F1 Biglycan determines pro- and anti-inflammatory signaling response by switching between TLR2/TLR4/CD14 and TLR4/CD44 7097 7099 960 929 4615 114548 10563 3606 PMC7718394__F5 Simplified diagram illustrating altered innate signaling following BCG treatment of HU and HEU monocytes 7097 4615 1437 5743 29949 2920 6348 51561 7130 2919 6354 9966 PMC7720011__F1 Functional pathway of androgens and its receptor 5728 2078 7113 7040 PMC7721010__F8 Schematic regulation mechanism of miR-361-3p on lymphoma cell behaviors 80326 1499 595 PMC7724349__F8 Selaginellin B induces autophagy and apoptosis in ASPC-1 and PANC-1 cells through activating the JAK2/STAT3 signal pathway 596 3717 6774 PMC7731470__F4 Illustration of the effects of polycystins dysfunctioning on EGFR and MAPK/ERK pathway 3479 1950 1956 2885 PMC7736543__F1 Adrenal cortex employs multiple cell populations with stem cell function to support cellular renewal 7490 6469 1585 PMC7744503__F7 Mycoplasma pneumoniae lipids license TLR‐4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response 7099 114548 3553 PMC7751845__F8 Crosstalk between HepG2 cells and TAMs-like macrophages 100507056 8091 619501 PMC7753989__F6 Schematic model depicting the role of ADAM17/HB‐EGF/EGFR signalling pathway in directional collective migration of epidermal cells 6868 1839 1956 PMC7754534__F6 Proposed model of adenine-activated-hepcidin axis Adenine induces activation of cAMP/PKA signaling pathway, which in trun stimulates the activation of both SMAD1/5/8 pathways resulting in transcritional activation of hepcidin gene expression 4086 4089 57817 PMC7763279__F3 Interplay of WNT and PPARG Signaling in Vascular Calcification 1499 595 8841 324 22943 6423 6425 4040 4041 PMC7763502__F1 Effect of Brassicaceae bioactives compounds upon the transcription of genes related with inflammation 2810 9817 7099 PMC7764600__F3 Cellular degradation pathway of autophagy plays a fundamental role in immunity 7099 2475 54106 PMC7765317__F3 Reactive oxygen species (ROS) trigger fibrosis via several inflammatory pathways 7099 3553 114548 10628 4615 PMC7768821__F9 Possible mechanism(s) of suppression of alcoholic hepatosteatosis by physcion 114548 5465 3553 406 9575 PMC7776261__F6 Proposed model to illustrate the regulation of quiescence stage of persisting chronic myeloid leukemia (CML) leukemic stem cells by their microenvironment 652 650 6774 3717 PMC7779537__F8 Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS 4087 4088 5054 4089 7157 PMC7790228__F11 TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response 1101 57506 6009 7187 29110 10342 2475 3661 107966124 PMC7791174__F7 Illustrations of TRPV6 as a critical regulator in osteoclastic bone resorption 55503 3484 3480 PMC7792426__F7 Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment 3486 3489 4088 4087 6364 3479 3488 PMC7794044__F4 Signalling pathways activated by peptidoglycan upon stimulation of NOD-like receptors 55054 64127 8767 7189 64170 22861 114548 3665 91662 3553 PMC7795665__F3 PPARG involved in trophoblast differentiation 100302142 1499 8521 PMC7796222__F5 Postulated metabolic pathway of Alpha-PHP and 4F-Alpha-PVP 2153 2152 2147 PMC7798998__F2 Innate immune signaling pathways sensing SARS-CoV-2 115004 7098 51284 51311 57506 4615 PMC7803563__F1 Schematic model showing that the DEGs in the older melanoma patients by recurrence status converge at the Wnt signaling pathway 5743 1499 3553 2353 PMC7804279__F4 The Hippo pathway in the pathogenesis of inflammatory bowel disease 7422 9113 26524 PMC7806239__F7 Positive Feedback Loop Between TGFB and Androgen Receptor Supports Triple-negative Breast Cancer Anoikis Resistance 4088 4087 4089 367 PMC7823972__F2 MSC-exosomes are capable of protecting against radiation-induced damage to hematopoietic and nonhematopoietic systems 1950 724024 407006 406947 406992 9242 PMC7826431__F3 Open questions regarding NB–MSC interactions 3480 4853 6774 6352 PMC7829660__F3 Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action 7099 3929 929 114609 4615 PMC7840349__F2 Recent Updates of Lipoprotein(a) and Cardiovascular Disease 5340 7035 7006 100124696 PMC7843416__F1 Type I interferonopathy-associated genes are involved in the sensing and metabolism of viral RNA 8635 25939 11277 PMC7851912__F7 The NELFE/Beta-catenin/CSNK2B signaling axis in GC progression 7936 1499 1460 PMC7852227__F7 Schematic diagram 2002 2296 1789 7054 1491 619501 PMC7855580__F2 Systemic inflammatory response from SARS-Cov-2 may trigger atherosclerosis 114548 718 7124 PMC7859462__F4 Impact of 3′UTR APA on its target mRNA and protein 961 5879 6418 PMC7862465__F2 Glycosylation changes in TGFB activation and SMAD-dependent pathway 7939 4087 4088 4092 4089 PMC7864190__F2 Latent TGFB activation and the canonical TGFB signaling pathway 7939 4088 4087 PMC7868402__F6 LncRNA H19 regulates the gene pathway of osteogenic differentiation through the lncRNA-miRNA-mRNA network (; ; ; ; ) 283120 100033819 9759 10014 860 PMC7873381__F1 ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis 324 1452 2932 8312 1499 26137 5468 619501 PMC7875488__F7 A HH/Gli-Foxf1-Wnt signaling network controlling Sox9+ chondrogenesis 7477 6469 3549 147111 7481 54361 2294 340419 6662 PMC7880350__F8 Schematic illustration the contribution of FGF23 induced by post-infarct heart failure to promoting renal fibrosis 8074 7454 2264 2932 1499 PMC7883771__F3 RA signaling and OFCs 4040 220 1356 1592 56603 473 6899 6469 PMC7887310__F1 IFN action on cellular metabolism pathways 3620 9023 355 PMC7888496__F4 Proposed model of the role of the JAK-STAT signaling pathway in the development of FLHS in chickens 3569 9021 1270 5770 3717 6774 5771 PMC7890031__F2 IL-17A on osteoblasts 860 4280 3553 6774 650 PMC7893136__F3 Effect of treatment with EPS L (A,B) or EPS P (B) on apoptotic signaling pathway 3553 8743 8797 8737 3654 7186 598 PMC7910618__F4 Cancer-associated fibroblast-derived SDF-1 induces epithelial-mesenchymal transition of lung adenocarcinoma via CXCR4/Beta-catenin/PPARD signalling 7852 1499 5467 PMC7917704__F6 HMGA2 is regulated by the RAF kinase inhibitor protein (RKIP) pathway 8091 6352 6383 PMC7918075__F4 Putative model for the involvement of cell signaling pathways in the induction of survival by type I (A/B) and II (G) IFNS in CLL cells 6714 3717 7297 3716 6774 PMC7921639__F1 Metrnl regulates the intracellular signaling pathway 6774 284207 10014 23216 PMC7926383__F6 Genes of the VEGF-C/VEGFR-3 signaling pathway known to be involved in hereditary lymphedema 7424 5340 9508 2324 5045 PMC7927067__F9 STAT1 and STAT3 regulation of inflammation and growth arrest phenotypes in senescent preadipocytes 6774 6772 3627 4600 9636 115004 PMC7929927__F8 BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection 359710 55738 54732 PMC7934404__F2 GBPs regulate host antiviral innate immune signaling pathways 57506 115362 388646 3661 3665 6773 115361 PMC7934812__F2 Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation 7099 114609 4615 7189 3661 3553 PMC7937695__F2 Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease 23411 7099 10628 79792 PMC7940388__F6 Signaling pathway mediated by CBD in SH-SY5Y cells 7442 2475 8408 9706 PMC7941218__F3 GDF‐5 signalling pathway and regulation of GDF‐5 expression 8200 9242 2932 1499 324 4089 4090 7227 6664 6935 5307 1280 4322 176 PMC7941705__F2 Anesthetic affect pro- and anti-cancer miRNA expressions leading to cancer biology changes 3091 4313 4318 4322 2638 619501 PMC7969034__F8 Working model of IFI16/p204 recognizing dsDNA to active downstream signaling pathway 3428 29110 3661 PMC7972191__F7 Graphic abstract showing how the KPNA2/CBX8/PRDM1/c-FOS pathway works in BCa 57332 3838 639 54880 PMC7975703__F7 Proposed Schematic for AKR1B10 activating TLR4/NFKB signaling pathway by promoting FFA synthesis in NPC 7099 54472 4615 57016 PMC7979537__F8 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling 1139 3717 6774 6657 PMC7980590__F6 Flow chart for the functions of miR-4429 and DLX1 in PCa cells 55364 1745 1499 PMC7990793__F2 Differences of inhibitory effects between homodimeric and heterodimeric IL-35 10148 3716 7297 6775 3595 PMC7991784__F2 Changes in proteins or metabolites of lipid metabolism pathway affect the life cycle of HBV: potential targets for HBV suppression 355 348 5091 6713 3156 PMC7996988__F8 Induction of interferonB and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells 6772 10379 3455 3454 PMC7997242__F4 CD226 downregulation 10666 8320 6714 PMC8000248__F4 Non-coding RNAs regulating Notch Signaling 140828 6868 100423029 PMC8004153__F1 TGFB signalling is triggered through BMP or TGFB ligands 7046 7049 4092 4091 57154 4087 4088 64750 4090 4086 4089 PMC8004153__F4 The TGFB signalling pathway by miRNAs 7046 7049 4087 4088 100126297 4089 693194 PMC8006404__F7 Proposed mechanism about excessive caffeine intake-disturbed differentiation of myogenic progenitors through retinoic acid (RA) signaling pathway 5081 4205 4617 57644 PMC8009949__F6 Part of C21-steroird biosynthesis pathway 6770 1586 3284 1584 PMC8013977__F5 IL-15-JAK-STAT5 signaling for NK cell development 3717 3718 6776 8835 9021 7422 PMC8016451__F8 Schematic diagram showing the mechanism by which Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis 3157 3949 3156 55366 PMC8017232__F7 Proposed model depicting the involvement of TIPE2 in the RIG-I signaling pathway 1283 57506 29110 3661 PMC8017486__F1 The design and application of AE@NPs for enhanced PC treatment 1950 1956 6774 PMC8024302__F4 Effect of extracellular vesicles on the regulation of mitochondria under hypoxia 114548 3553 8011 54106 4615 PMC8024309__F8 LncRNA MALAT1 promotes gastric cancer progression via inhibiting autophagic flux and inducing fibroblast activation 1994 5728 378938 2475 8878 2638 PMC8024996__F1 Struggle of a good friend getting old: cellular senescence in viral responses and therapy 115004 23410 11277 1777 3661 3169 PMC8025964__F6 Summary of SEPT6-regulated Hippo/YAP signaling pathway in HCC 9113 595 4313 619501 PMC8034822__F4 Divergent cytokine pathways drive fibrosis 7124 920 85480 64806 PMC8036623__F2 Proteolysis on the VEGF pathway 5340 4313 6772 4318 PMC8037903__F1 Role of gut in inducing adipose tissue inflammation 3929 7099 929 PMC8042267__F1 IL23 signaling in Crohn’s disease 6774 6775 3605 50616 149233 3594 3595 PMC8042267__F2 IL23 mediated resistance to apoptosis of mucosal CD4+ T cells in anti-TNF refractory Crohn’s disease patients 920 6774 149233 PMC8042267__F3 IL23 in the development and activation of Th17 cells 3569 149233 920 3605 PMC8048169__F7 Graphical summary of the investigated signaling pathways during osteogenic differentiation of DFCs 650 7474 2932 1499 PMC8057295__F4 Models of the SHH signaling pathway in cancer 6608 5727 51684 2736 6469 PMC8060499__F1 Possible involvement of the complement system (CS) in the recruitment of neutrophils and the formation of NETs in Alzheimer's disease 1431 3383 1378 PMC8064165__F8 Dual activation of Hedgehog and Wnt/Beta-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer 4040 4041 1499 51684 6608 PMC8071157__F3 MicroRNAs involved in aromatase regulation in breast cancer 1588 406911 2475 407019 1385 2494 PMC8071872__F5 Lack of Cell Cycle Inhibitor p21 and Low CD4+ T Cell Suppression in Newborns After Exposure to IFNB 920 6772 51199 6773 10379 PMC8073943__F5 EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer 2042 1786 2146 5728 PMC8079635__F1 Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes 4318 374 90865 5008 3976 5045 6348 PMC8080632__F8 Schematic diagram illustrating the theory in the current study 387 7474 4761 PMC8088128__F5 Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective 8036 5894 673 PMC8097341__F2 Various mechanisms underlying targeting of de novo DNMTs by histone methylation 1788 1789 7468 64324 29947 29072 PMC8109080__F9 Mechanistic schematic diagram showing Compound 3C alleviates atherosclerosis by multiple mechanisms 3717 6772 348 7038 PMC8112564__F6 ANKRD22 enhances breast cancer cell malignancy by activating the Wnt/Beta-catenin pathway via modulating NuSAP1 expression 118932 51203 1499 PMC8120474__F8 Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis 1499 4772 2932 PMC8124226__F7 Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in Combination with Quercetin Inhibit Colorectal Cancer Development in ApcMin/+ Mice 1499 51176 10023 5515 8066 324 2932 6468 PMC8125586__F3 Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics 120227 1576 1594 1591 PMC8131681__F1 Smad Dependent TGFB and BMP Signaling Pathway in Bone Remodeling and Therapies 4086 4087 4088 4090 4089 4091 4092 PMC8131720__F8 Downregulation of miR-218 by porcine reproductive and respiratory syndrome virus facilitates viral replication via inhibition of type I interferon responses 9021 7297 6772 10379 3716 PMC8133338__F1 Erythropoietin in bone homeostasis—Implications for efficacious anemia therapy 2056 930 4280 PMC8136123__F5 Histone deacetylase-2: A potential regulator and therapeutic target in liver disease (Review) 1950 3066 619501 2475 5728 PMC8145016__F2 Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients 8074 2264 7421 PMC8156839__F1 Survey of Bacterial Microcompartment Distribution in the Human Microbiome 2912 2911 2914 2916 2913 2915 PMC8160143__F8 Bacterial and viral induced expression of IL22 6288 3569 3552 7124 50616 3574 3456 PMC8160512__F8 Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells 1080 3569 4060 PMC8165101__F5 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives 5727 2736 2737 51684 6608 PMC8165235__F1 Perspective: Humanized Pig Models of Bladder Cancer 3265 5290 2261 5728 PMC8166571__F1 Diet Regulation of Long-Chain PUFA Synthesis: Role of Macronutrients, Micronutrients, and Polyphenols on Δ-5/Δ-6 Desaturases and Elongases 2/5 9415 54898 2717 60481 3992 PMC8167111__F6 FGF2/MAST4/ERM pathway in SSC self-renewal 375449 2247 6387 6374 255877 PMC8167992__SF1 Targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer 7422 6774 1901 PMC8168945__F6 Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling 50846 3549 6469 PMC8170089__F1 EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress 4087 9839 6093 9475 1803 3458 4853 7048 PMC8172903__F1 STING1 network regulates autophagy and cell death 340061 4790 3661 115004 PMC8175077__F2 Intracellular Free Neu5Ac Metabolism and Associated Genetic Disorders 10020 80896 10559 26503 PMC8177011__F7 Expression of Nutrient Transporters on NK Cells During Murine Cytomegalovirus Infection Is MyD88-Dependent 4615 90865 325 PMC8184824__F6 HJURP in PCa cells 55355 2932 1026 PMC8196501__F8 Photoactivation of TGFB/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model 7939 4086 4090 4093 4089 4087 4088 1641 2670 PMC8196896__F3 Transmembrane TNF and Its Receptors TNFR1 and TNFR2 in Mycobacterial Infections 7186 7185 7124 PMC8202900__F7 Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFB1–smad/p38MAPK–lnc865/lnc556–miR-29b-2-5p–STAT3 signal pathway 7040 6774 4087 9314 PMC8217840__F1 LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease 7097 120892 4773 PMC8220219__F2 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer 4040 4041 1499 324 2932 6925 2146 100505633 22943 PMC8223826__F1 Exosomes in diagnosis and treatment of colorectal cancer 928 967 975 PMC8226215__F1 Assembling Disease Networks From Causal Interaction Resources 5795 1950 1956 5594 2885 PMC8226626__F1 JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms 3565 3569 3589 386653 7297 3718 6778 3596 6772 6774 1950 3717 PMC8228270__F1 HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response 10379 3716 7297 9636 51191 9246 PMC8228270__F2 HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response 9636 51191 9246 PMC8236123__F9 Activated neutrophils polarize protumorigenic interleukin‐17A‐producing T helper subsets through TNF‐A‐B7‐H2‐dependent pathway in human gastric cancer 6372 3576 3577 920 PMC8251784__F4 In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae 64127 9235 920 50489 PMC8253640__F2 Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis 2475 83667 4151 PMC8255631__F2 Autoimmunity as an Etiological Factor of Cancer: The Transformative Potential of Chronic Type 2 Inflammation 1493 324 942 941 940 3565 3596 PMC8262160__F6 Knockdown of GPSM1 Inhibits the Proliferation and Promotes the Apoptosis of B-Cell Acute Lymphoblastic Leukemia Cells by Suppressing the ADCY6-RAPGEF3-JNK Signaling Pathway 26086 112 10411 PMC8268639__F1 NUAK1 and NUAK2 Fine-Tune TGFB Signaling 4087 4088 4089 9891 81788 PMC8282792__F8 Proposed model for the dysregulation DEPDC5-mTORC1 axis in the pathogenesis of alcohol-induced hepatic steatosis 84861 9681 5465 PMC8284746__F2 Metabolic Control of Mouse and Human Astrocytes 57506 6347 7124 PMC8288800__F6 Long noncoding RNAs and tumour microenvironment 105416157 3191 6347 PMC8294190__F5 Emerging Biological Functions of IL-17A: A New Target in Chronic Obstructive Pulmonary Disease? 6774 7124 50943 260431 PMC8294626__F8 H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease 4040 4041 10159 2020 8313 1499 PMC8296592__F8 EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/Beta-catenin signaling 1499 650 860 7422 25975 PMC8301371__F8 TLR7 Activation of Macrophages by Imiquimod Inhibits HIV Infection through Modulation of Viral Entry Cellular Factors 4615 51284 7186 6774 3716 7297 920 1234 PMC8303465__F1 Sex Maintenance in Mammals 6736 6662 54361 1761 268 668 10468 PMC8308723__F1 Signaling Pathway and Transcriptional Regulation in Osteoblasts during Bone Healing: Direct Involvement of Hydroxyapatite as a Biomaterial 4090 4086 4089 860 1499 PMC8316766__F1 Genetic Polymorphisms Associated With the Pharmacokinetics, Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and Risperidone 7365 54657 5243 1544 1558 1565 PMC8318865__F7 Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses 7099 7096 10333 3661 3665 7097 4615 64135 8519 3454 3455 6772 6773 10379 5359 PMC8323274__F6 NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway 9572 9021 6774 PMC8324684__F3 Metabolic-associated fatty liver disease and lipoprotein metabolism 7038 338 4547 53345 PMC8326113__F6 CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways 10663 102 58191 PMC8327141__F4 The MCTS1 and DENR Proteins in Regulating the Mechanisms Associated with Malignant Cell Transformation 5728 28985 6714 387 PMC8327449__F3 PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression 7050 4089 4087 4088 PMC8336005__F5 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions 4040 4041 2932 324 84133 84870 55366 6425 1499 6934 PMC8348949__F2 Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime? 6469 6608 9423 PMC8348973__F2 Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease? 7097 7124 7100 PMC8350063__F7 LGI1 governs neuritin-mediated resilience to chronic stress 10014 4209 3667 9211 PMC8353273__F1 Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases 3661 115004 29110 PMC8353504__F1 Hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders 126129 181 4852 1374 PMC8356724__F1 The BMP-2 signaling pathway 650 4090 4086 4089 7018 PMC8375100__F1 Kynurenine pathway metabolites in cerebrospinal fluid and blood as potential biomarkers in Huntington's disease 3620 169355 8564 PMC8377944__F1 Secondary hypertension: An update on the diagnosis and localisation of a pheochromocytoma or paraganglioma 5409 1312 7054 PMC8385202__F3 Multi-functional roles of forkhead box protein O in skin aging and diseases 9370 4851 6364 5055 PMC8389593__F3 Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway 2932 1585 4040 PMC83901__F8 Model of the regulation of class II MHC genes by IFNG 3458 3716 3717 6772 4261 PMC8392322__F1 Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia 3718 6774 6775 3717 7297 6772 6778 3716 6773 PMC8394875__F3 Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology 4040 4041 1499 8313 8312 2932 324 84133 54894 8549 59352 PMC8397941__F3 Mechanistic Insight into the Effects of Curcumin on Neuroinflammation-Driven Chronic Pain 1524 7018 7099 PMC8402591__F1 Efficacy of COVID-19 Vaccines in Chronic Kidney Disease and Kidney Transplantation Patients: A Narrative Review 2056 941 942 324 2475 PMC84078__F7 Schematic of the influence of Notch on MEF2C and myogenic bHLH factor interactions 4205 4208 4209 PMC8416724__F3 CD47/SIRPA pathway mediates cancer immune escape and immunotherapy 140885 961 115004 3661 PMC8423434__AF1 Principles of signaling pathway modulation for enhancing human naive pluripotency induction 3976 6714 3516 PMC8424636__F7 Nicorandil inhibits TLR4/MyD88/NFKB/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction 7099 4615 114548 79792 PMC8430223__F5 Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases 7124 10631 114548 3553 PMC8431187__F2 Myeloma–Bone Interaction: A Vicious Cycle via TAK1–PIM2 Signaling 11040 6774 3717 7412 7124 PMC8431390__F1 Nucleic Acid Sensing in the Tumor Vasculature 57506 115004 11277 PMC8432036__F5 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies 4092 7046 4087 4088 4089 PMC8432036__F6 Canonical TGFB Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies 7046 4092 4087 4088 4089 PMC8435685__F1 Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach 102 6868 5045 1499 29102 54487 PMC8436617__F3 N6-Methyladenosine in Cancer Immunotherapy: An Undervalued Therapeutic Target 56339 114609 941 958 6774 57721 200734 PMC8441304__F6 SUMO‐mediated DNA replication‐independent DPC repair 10293 6047 83932 PMC8442523__F2 TRPV1 in the pain pathway: similarities and differences between desensitization by agonists and blockade by antagonists 83737 7442 4803 PMC8445516__F2 Robinow syndrome-associated genes involved in the WNT/PCP pathway identified in human subjects 4920 2535 64359 PMC8446193__F2 Murine Models Provide New Insights Into Pathogenesis of Chronic Graft-Versus-Host Disease in Humans 324 7054 969 7006 100124696 6774 5132 920 PMC8446364__F1 She Doesn’t Even Go Here: The Role of Inflammatory Astrocytes in CNS Disorders 2670 2475 4097 3553 6347 3627 3552 6352 PMC8447515__F6 Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs 3479 2475 6774 PMC8453015__F3 Function of Protein S-Palmitoylation in Immunity and Immune-Related Diseases 3661 29110 115004 PMC8455910__F10 Gardenoside Hinders Caspase-1-Mediated Hepatocyte Pyroptosis Through the CTCF/DPP4 Signaling Pathway 10664 1803 114548 PMC8465210__F3 Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity 4088 4087 4089 PMC8472484__F9 Ailanthoidol, a Neolignan, Suppresses TGFB1-Induced HepG2 Hepatoblastoma Cell Progression 465 1000 4313 PMC8473072__F7 MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes 1843 3726 3725 2353 PMC8481577__F6 TNF-Alpha Pathway Alternation Predicts Survival of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer 7124 920 4283 3627 325 PMC8487948__F1 WNT signaling pathway 4040 4041 79971 64840 324 84133 54894 55366 8549 59352 607 PMC8490662__F8 Macrophage-Mediated Bone Formation in Scaffolds Modified With MSC-Derived Extracellular Matrix Is Dependent on the Migration Inhibitory Factor Signaling Pathway 9242 2247 7043 5008 4282 972 960 PMC8495205__F1 Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents 367 1583 1586 3169 9611 9612 PMC8497904__F6 Lgr4 Regulates Oviductal Epithelial Secretion Through the WNT Signaling Pathway 55366 1499 2494 1583 3283 PMC8498718__F3 RNA-seq profile of African American men with a clinically localized prostate cancer 57654 6415 7157 55805 PMC8508518__F2 Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer 6714 8651 9021 PMC8511434__F4 Type 3 Innate Lymphoid Cells as Regulators of the Host-Pathogen Interaction 6774 3934 7124 864 6775 2867 114548 PMC8522258__F4 Synergistic metabolic pathways that lead to a hyaluronan storm, NETosis, coagulopathy, and immune suppression 3037 6774 1956 6772 23411 PMC8526928__F2 Rhinovirus Immunity and Asthma 6773 10379 7297 6772 3455 3716 PMC8533980__F5 CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer 3661 29110 115004 PMC8535311__F3 Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis 4092 64750 57154 4089 7042 4087 4088 7045 PMC8538975__F4 Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed 8771 115650 7186 3459 8737 330 7097 7099 3460 7098 148022 7850 51284 23643 1440 3458 2826 5473 3606 51311 268 64109 1441 1439 652 8646 PMC8541918__F4 Compartmentation of the Wnt pathway by LLPS 324 2932 1499 4040 4041 PMC8545469__F7 T6SS translocates a micropeptide to suppress STING-mediated innate immunity by sequestering manganese 115004 29110 3661 PMC8557709__F2 Hypothalamic endocannabinoids in obesity: an old story with new challenges 23237 1325 5443 3953 4852 181 PMC8564637__F7 MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB‐EGF/EGFR pathway 4204 1385 3232 1839 1956 PMC8568271__F5 Interleukin-1 activation of NF-kB through Ajuba 1540 7189 84962 PMC8568546__F3 RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A 4838 4087 4088 54915 56339 3717 51441 PMC8572559__F2 JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms 3717 6774 6778 PMC8572801__F7 Mucin 20 modulates proteasome capacity through c‐Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma 3082 2002 51371 200958 PMC8575759__F7 Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor Response 7098 7097 4615 7099 PMC8577254__F2 Retinoic acid in the commitment to meiosis 64220 157506 216 8854 220 1592 56603 340665 PMC8579759__F4 Oh, the Mutations You’ll Acquire! A Systematic Overview of Cutaneous Squamous Cell Carcinoma 4089 4092 4087 4088 PMC8589410__F10 Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome 2243 2266 718 PMC8591135__F3 Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems 7097 7096 4615 51135 3654 7189 10333 7099 7187 3661 7098 51284 51311 54106 PMC8596126__F8 M6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons 51441 7976 54915 PMC8596927__F12 TRPV4-induced Müller cell gliosis and TNFA elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NFKB pathway 59341 3717 6774 2670 PMC8596933__F6 CXCL14 facilitates the growth and metastasis of ovarian carcinoma cells via activation of the Wnt/Beta-catenin signaling pathway 9547 1499 8313 PMC8597024__F6 Identification of miR-499a-5p as a Potential Novel Biomarker for Risk Stratification in Endometrial Cancer 1499 2932 324 PMC8598044__F1 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion 57506 7189 3661 PMC8598044__F2 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion 5728 57506 3661 54106 29110 6772 6773 PMC8598044__F3 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion 29110 10128 3661 57506 PMC8602361__F1 Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease 920 114548 7097 7099 PMC8604044__F2 Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder 3156 4204 6713 PMC8607377__F2 Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia 6774 6935 9839 PMC8616315__F2 Multiple Interactions of RUNX with the Hippo–YAP Pathway 9113 26524 864 PMC8617589__F10 Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity 140606 3934 1052 10628 7295 6774 PMC8619244__F2 TRPV4 Mechanotransduction in Fibrosis 4087 4088 4089 3725 6885 2353 PMC8620939__F3 MTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy 2475 7942 7030 201163 PMC8623546__F9 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease 6608 5727 51684 PMC8628183__F1 ER signaling mechanisms 7018 6714 2852 PMC8628653__F1 Disruption of the Diurnal Cortisol Hormone Pattern by Pesticide Use in a Longitudinal Study of Farmers in Thailand 6770 1583 1589 1585 1586 1584 PMC8631414__F5 Low-intensity extracorporeal shock wave therapy promotes recovery of sciatic nerve injury and the role of mechanical sensitive YAP/TAZ signaling pathway for nerve regeneration 4803 2668 627 PMC8635784__F5 Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis Rats Through Inhibiting the TLR4-MyD88-NFKB Signaling Pathway 7099 4615 51135 3654 PMC8637879__F2 Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy 114548 10628 79792 1687 PMC8641876__F1 Schematic depiction of the regulatory network of YAP/TAZ 23411 9113 26524 PMC8642962__F6 Novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/Beta-catenin signaling pathway 23314 1499 22943 PMC86511__F9 Common and distinct activities of TGFB and BMP in C2C12 cells 4089 4090 4086 4087 4088 860 PMC8657588__F1 Toll-like Receptors (TLRs) Mediated Inflammation in Pancreatic Cancer Pathophysiology 7096 7097 10333 4615 6364 3569 3661 7099 54106 7100 51311 51284 7098 PMC8660639__F7 Proposed mechanistic scheme of PCID2 in promoting the canonical Wnt signaling pathway in colorectal cancer 55795 5371 1499 595 PMC8660693__F1 Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response 115004 3661 7124 PMC8664592__F8 HSP27 Protein Dampens Encephalomyocarditis Virus Replication by Stabilizing Melanoma Differentiation-Associated Gene 5 57506 29110 10010 3661 PMC8666372__F3 Activated and inactivated canonical Wnt signaling 22943 4040 4041 324 6425 11197 PMC8670263__F1 CGAS–STING pathway: more than fighting against viruses and cancer 29110 3661 115004 PMC8671602__F4 DExD/H-box helicases: multifunctional regulators in antiviral innate immunity 55308 56919 114548 1654 1660 171389 3553 1665 3661 57506 PMC8678597__F1 Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production 115004 29110 3661 PMC8695973__F2 Multiple Functions of the Dmrt Genes in the Development of the Central Nervous System 5080 63951 429 63950 58524 170825 9355 2018 2290 PMC8697421__F3 Type I IFN immunity in viral pneumonia 7098 3661 3665 81622 7187 29110 3454 3455 6773 6772 10379 PMC8700581__F3 Senescence Alterations in Pulmonary Hypertension 3569 50507 659 PMC8700621__F5 Transcriptome Analysis of Induced Pluripotent Stem Cells and Neuronal Progenitor Cells, Derived from Discordant Monozygotic Twins with Parkinson’s Disease 2895 5309 64805 3624 7124 7026 54567 9965 22943 7476 PMC8703482__F2 B Cell Involvement in the Pathogenesis of Ankylosing Spondylitis 23411 567 972 PMC8710987__F3 Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches 2539 5209 2167 PMC8711024__F7 Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL-mediated NFKB and JNK and their downstream signalling pathways 7189 4772 100187907 81501 PMC8711784__F1 Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion 10379 3454 7297 3716 6772 3455 6773 115004 29110 PMC8711784__F2 Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion 115004 29110 3661 PMC8714844__F6 Recent Progress in Lymphangioma 2050 2717 1948 7424 5290 2475 1431 PMC8718186__F1 cGAS‒STING signaling and function in metabolism and kidney diseases 29110 3661 115004 PMC8718194__F2 Crosstalk between the caspase family and the cGAS‒STING signaling pathway 115004 29110 3661 3553 317 PMC8729140__F8 Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming 355 51094 79602 23411 PMC8740226__F15 Effect of Chinese Herbal Medicine Mixture 919 Syrup on Regulation of the Ghrelin Pathway and Intestinal Microbiota in Rats With Non-alcoholic Fatty Liver Disease 2693 4852 5443 PMC8741964__F1 Impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites 8942 8564 23475 PMC8745273__F6 Brachygnathia Inferior in Cloned Dogs Is Possibly Correlated with Variants of Wnt Signaling Pathway Initiators 5583 5332 23291 57526 PMC8746116__F6 Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic A‐ and B‐cells 9817 4780 8878 2729 2941 1728 2947 2730 120227 7355 PMC8749970__F2 Tumor-Associated Macrophages in Hepatocellular Carcinoma Pathogenesis, Prognosis and Therapy 6347 1499 3627 3569 3586 6362 6364 PMC8772744__F5 Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease 4087 4088 4089 4092 PMC8773363__F3 Atoh8 in Development and Disease 4089 4090 4086 4091 84913 PMC8773898__F2 MicroRNAs and Long Non-Coding RNAs in Sarcopenia 4208 4656 4617 3488 3667 PMC8781535__F2 Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium 3454 7297 6772 3455 3716 163702 6773 10379 PMC8783172__F4 What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability? 4615 3654 51284 7189 3661 3665 PMC8787930__F1 Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer 5091 961 574456 PMC8794746__F2 New Insights into LINC00346 and its Role in Disease 26099 54882 79027 PMC8802127__F7 Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway 283460 56648 2638 PMC8811971__F1 IKK-mediated CYLD phosphorylation and cellular redox activity 9817 1540 8737 PMC8819539__F1 Periodontal Ligament Stem Cell-Derived Small Extracellular Vesicles Embedded in Matrigel Enhance Bone Repair Through the Adenosine Receptor Signaling Pathway 2247 5111 596 PMC8826716__F10 Transmembrane p24 trafficking protein 2 regulates inflammation through the TLR4/NFKB signaling pathway in lung adenocarcinoma 7099 10959 1956 PMC8835057__F7 Cytokine Receptors—Regulators of Antimycobacterial Immune Response 3717 3716 6772 PMC8847772__F1 Search for Biomarkers and Treatments in Chagas Disease: Insights From TGF-Beta Studies and Immunogenetics 352963 7939 4092 4089 4087 4088 PMC8847900__F2 Human biosynthetic pathway for trace amines and catecholamines 1312 5409 1621 PMC8855423__F6 Lovastatin Inhibits RhoA to Suppress Canonical Wnt/Beta-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer 387 2932 1499 PMC8859442__F2 Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications 50507 9242 27035 PMC8865078__F7 Transforming Growth Factor-Beta-Regulated LncRNA-MUF Promotes Invasion by Modulating the miR-34a Snail1 Axis in Glioblastoma Multiforme 65981 4088 4087 4089 PMC8867697__F1 Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease 1356 718 1431 727 PMC8867758__F4 MicroRNA regulates the toxicological mechanism of four mycotoxins in vivo and in vitro 100616437 572 10298 2353 PMC8869457__F1 Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer 1499 4040 4041 324 54894 84133 607 81839 387 5879 PMC8870127__F1 Bright and the Dark Side of TGFB Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications 4087 4088 4091 4092 4089 7046 PMC8877887__F2 THAB Immunological Pathway as Protective Immune Response against Prion Diseases: An Insight for Prion Infection Therapy 5132 59067 3586 6772 6773 920 PMC8884172__F10 Downregulation of Three Immune-Specific Core Genes and the Regulatory Pathways in Children and Adult Friedreich's Ataxia: A Comprehensive Analysis Based on Microarray 7503 647979 729082 114915 283120 940 100124700 104355217 100131067 100505641 100507246 378938 355 283131 PMC8886744__F2 Apolipoprotein A1 in PPAR Signaling Pathway for Nonalcoholic Fatty Liver Disease 348 3605 7099 355 7124 6347 PMC8895170__F3 Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease 27329 4023 338328 7038 PMC8898246__F2 Where are we in 2021 with heart failure with reduced ejection fraction?—current outlook and expectations from new promising clinical trials 4879 5225 10699 5045 PMC89003__F2 IFN signaling by the Jak-Stat pathway 7297 3716 3717 6772 3455 3459 PMC8901701__F1 Immunopathology and Immunotherapy of Inflammatory Skin Diseases 7297 149233 3717 6774 1235 6364 3576 2919 PMC8921626__F4 Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach 2950 220042 7832 23612 5514 54658 3397 900 316 PMC8922216__F2 Metabolic and Signaling Roles of Ketone Bodies in Health and Disease 65985 47 23152 55902 PMC8924130__F3 Glioma: molecular signature and crossroads with tumor microenvironment 7124 1956 2475 3091 4255 920 PMC8929449__F5 Smoking-induced changes in buccal mucosal gene expression 650 894 4087 1365 6198 3685 9444 PMC8941656__F1 Evaluation of Iron Deficiency and Iron Overload 3569 2056 654 7036 3077 148738 PMC8946735__F3 Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease 2563 57084 2891 2562 2564 2786 54331 2785 3760 2778 9568 57468 2744 PMC8955121__F6 Rotavirus-Mediated Suppression of miRNA-192 Family and miRNA-181a Activates Wnt/Beta-Catenin Signaling Pathway: An In Vitro Study 4040 1499 894 4089 PMC8960951__F1 Role of Chronic Physical Exercise as a Treatment in the Development of Vitiligo 4283 3627 2833 3553 324 940 3586 50943 PMC8962276__F1 Uremic Toxin Lanthionine Induces Endothelial Cell Mineralization In Vitro 56172 249 650 860 PMC8965007__F5 Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation 6469 6608 4090 4086 PMC8980928__F6 Synovial tissue‐derived extracellular vesicles induce chondrocyte inflammation and degradation via NF‐KB signalling pathway: An in vitro study 3569 4322 11096 PMC8991687__F1 Targeting Chemokine Receptor CCR1 as a Potential Therapeutic Approach for Multiple Myeloma 860 6348 22943 6423 PMC8997602__F1 Impact of Lipid Metabolism on Antitumor Immune Response 3579 11001 6772 6774 PMC8997752__F5 Beyond PD-L1—Identification of Further Potential Therapeutic Targets in Oral Cancer 940 941 942 PMC8997759__F1 Liquid–Liquid Phase Separation in Cancer Signaling, Metabolism and Anticancer Therapy 4771 3661 29110 115004 PMC8998929__F3 Hippo Signaling in the Endometrium 6789 387 6876 PMC9013714__F7 Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway 1956 7124 3553 PMC9021824__F5 miR-1908 Dysregulation in Human Cancers 6497 4089 4087 4088 7045 3949 PMC9027975__F5 Interplay between Viruses and Host DNA Sensors 3428 3661 29110 PMC9028943__F2 Fate of Leydig Cells in Men with Spermatogenic Failure 1586 1588 1583 PMC9031669__F2 Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids 1581 1593 6718 9420 570 25801 4280 PMC9035791__F1 Th17 Pathway in Vascular Inflammation: Culprit or Consort? 50943 3606 6097 84818 3458 7124 PMC9035791__F4 Th17 Pathway in Vascular Inflammation: Culprit or Consort? 6097 3606 50943 PMC9035937__F4 Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease 3383 7422 7412 PMC9040139__F4 Immunopathogenesis of alopecia areata 3716 3717 3718 920 PMC9047906__F5 Serglycin Is Involved in TGFB Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue 1385 7003 6935 5552 960 4087 4088 4089 7040 7042 PMC9066914__F6 EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes 1950 6663 324 1956 10215 PMC9075007__F8 Working model for the effect of SULF2 monoclonal antibody 5D5 on PDGFRBeta-YAP signaling in CCA 5159 55959 7018 595 PMC9076866__F8 Mechanism by which Grem1 regulates the TGFB1/Smad2/3 signaling pathway in IVDD 26585 4088 4087 4089 PMC9096094__F5 Betaine Regulates the Production of Reactive Oxygen Species Through Wnt10b Signaling in the Liver of Zebrafish 7480 2932 1499 PMC9099610__F2 Poultry Meat and Eggs as an Alternative Source of n-3 Long-Chain Polyunsaturated Fatty Acids for Human Nutrition 2717 60481 54898 PMC9103886__F1 Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study 6774 595 596 4313 4318 6714 3082 PMC9109300__F7 Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1 8841 4089 4087 PMC9112182__F7 RNA Binding Motif Protein 3 Promotes Cell Metastasis and Epithelial–Mesenchymal Transition Through STAT3 Signaling Pathway in Hepatocellular Carcinoma 6774 7431 5935 7455 4318 4313 PMC9113239__F6 Fabrication and evaluation of a BMP-2/dexamethasone co-loaded gelatin sponge scaffold for rapid bone regeneration 860 650 4090 4086 3397 PMC9120235__F5 OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization 29925 29926 2821 4351 5372 5373 PMC9123888__F6 Possible mechanisms of the effect of melatonin in HDP cells 4543 4544 2932 1499 PMC9123899__F1 Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA) 3454 7297 3455 3716 10379 3459 3458 3460 3717 163702 3588 PMC9125963__F3 Mechanisms involved in controlling RNA virus-induced intestinal inflammation 1665 171389 57506 29110 3661 3665 PMC9125963__F4 Mechanisms involved in controlling RNA virus-induced intestinal inflammation 1660 1665 171389 56919 114548 79792 PMC9126881__F8 M2 macrophage-derived extracellular vesicles (EVs) on the development of ankylosing spondylitis (AS) through by transferring of microRNA-22-3p 8864 7477 1499 860 PMC9131283__F8 5-HT2B-mediated serotonin activation in enterocytes suppresses colitis-associated cancer initiation and promotes cancer progression 4087 4088 4089 6774 PMC9131992__F4 Non-structural proteins of bovine viral diarrhea virus 57506 3661 1283 PMC9138253__F6 Cross-Talk between Wnt Signaling and Src Tyrosine Kinase 387 9475 1499 4040 4041 6714 2932 6093 PMC9150122__F1 Biophysical Survey of Small-Molecule Beta-Catenin Inhibitors: A Cautionary Tale 1499 4040 4041 607 595 4316 PMC9152417__F8 Extracellular Vesicles Carrying miR-887-3p Promote Breast Cancer Cell Drug Resistance by Targeting BTBD7 and Activating the Notch1/Hes1 Signaling Pathway 55727 3280 4851 4280 PMC9157790__F2 Wnt Signaling in the Breast: From Development to Disease 22943 4040 4041 1499 11197 2932 324 8549 54894 84133 PMC9163386__F6 Component 1 Inhibitor Missense (Val480Met) Variant Is Associated With Gene Expression and Sepsis Development in Neonatal Lung Disease 3818 2160 2161 5340 1991 721 720 10747 716 3586 3569 5327 7124 PMC9163667__F2 Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury 324 1499 2932 4040 4041 PMC9164040__F2 Glance at the Molecules That Regulate Oligodendrocyte Myelination 1499 5091 2932 6934 PMC9167587__F6 Proposed pathway of quercetin in preventing CKD 4087 4088 4089 4092 PMC9167958__F7 Temperature and Growth Selection Effects on Proliferation, Differentiation, and Adipogenic Potential of Turkey Myogenic Satellite Cells Through Frizzled-7-Mediated Wnt Planar Cell Polarity Pathway 5879 8324 387 PMC9179862__F9 CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis 7852 6387 57007 PMC9180238__F1 MicroRNA-202 as a Diagnostic Biomarker and a Potential Tumor Suppressor 2475 647979 139628 3845 92140 5728 4613 378938 PMC9180565__F2 Interplay between Mast Cells and Regulatory T Cells in Immune-Mediated Cholangiopathies 50943 6774 3716 3718 3269 3569 920 PMC9181207__F1 Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis 25801 1581 1582 1593 570 9420 9023 10858 51302 PMC9200284__F1 Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy 1788 1789 6996 1786 PMC9201453__F3 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases 5154 9319 7069 619501 57447 PMC9201453__F4 Targeting Thyroid Hormone/Thyroid Hormone Receptor Axis: An Attractive Therapy Strategy in Liver Diseases 9320 11274 1734 PMC9203687__F1 ILC2s in Solid Tumors: Facilitate or Inhibit? 6352 4280 2920 PMC9208186__F7 Blockade of the Arid5a/IL-6/STAT3 axis underlies the anti-inflammatory effect of Rbpjl in acute pancreatitis 3516 10865 6774 3553 PMC9214686__F2 Signalling pathways downstream of cGAS and of endosomal TLRs 4615 51284 51311 54106 51135 3665 7098 29110 3661 115004 PMC9216458__F2 CD47–SIRPAlpha-targeted therapeutics: status and prospects 2690 961 920 PMC9218457__F6 Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1 1499 9242 58985 1755 6774 2932 PMC9220248__F2 Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity 85480 64806 90865 5340 PMC9236612__F8 Growth arrest and TRIM37 growth arrest activity 10733 4591 22852 116840 PMC9236768__F7 Jiawei Yanghe Decoction Regulates Bone-Lipid Balance through the BMP-SMAD Signaling Pathway to Promote Osteogenic Differentiation of Bone Mesenchymal Stem Cells 650 4090 4086 4089 860 PMC9237949__F7 Modularisation of published and novel models toward a complex KIR2DL4 pathway in pbNK cell 6850 4067 2885 PMC9239773__F6 Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics 6387 4089 4088 7874 PMC9243614__F3 Differential miRNA expression profiling of highly pathogenic avian influenza virus H5N1 infected chicken lungs reveals critical microRNAs, biological pathways and genes involved in the molecular pathogenesis 5966 4790 3484 1147 3487 3486 4792 3479 3553 3551 3488 3480 PMC9250438__F6 Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types 6774 3717 11122 3082 4313 PMC9253705__F40 Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway 4772 100187907 1513 6774 4313 PMC9253705__F7 Pexmetinib suppresses osteoclast formation and breast cancer induced osteolysis via P38/STAT3 signal pathway 4772 100187907 1513 6774 4313 PMC9260044__F2 Novel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target 7024 6662 2305 PMC9266893__F2 Iron, Neuroinflammation and Neurodegeneration 3569 2056 151176 654 7036 3077 148738 PMC9268386__F3 Estrogen-Related Receptor A: A Significant Regulator and Promising Target in Bone Homeostasis and Bone Metastasis 7474 7422 7040 2475 6354 7043 PMC9277309__F3 Molecular Mechanisms of Epigenetic Regulation, Inflammation, and Cell Death in ADPKD 355 7124 596 PMC9285118__F2 Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer 284110 55876 79792 1687 828 3002 3001 494513 PMC9295467__F2 Generation of Leydig-like cells: approaches, characterization, and challenges 1583 6770 1586 949 3293 3973 PMC9307784__F4 Orbital fibroblasts (OFs) in acute and chronic TED 958 3480 7253 PMC9313364__F7 Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma 6351 6774 285 PMC9317121__F9 BMP Signaling Pathway in Dentin Development and Diseases 650 653 4091 4092 4086 4090 4089 8195 7018 4087 4088 PMC9317121__F12 BMP Signaling Pathway in Dentin Development and Diseases 4086 4089 5308 7018 4090 PMC9319091__F11 VMP1 Regulated by chi-miR-124a Effects Goat Myoblast Proliferation, Autophagy, and Apoptosis through the PI3K/ULK1/mTOR Signaling Pathway 81671 59330 2475 PMC9319717__F2 Natural Biomolecules Targeting JAK/STAT/SOCS Signaling in the Management of Atopic Dermatitis 324 8651 9021 9655 386653 3565 PMC9321592__F6 IL‐20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis 4852 7432 6347 7097 2919 83737 4149 PMC9322955__F2 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts 4089 4087 4088 4092 PMC9326176__F2 Cathepsin K+ Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic Implications 1513 657 6774 3549 PMC9327201__F4 Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment 1440 6510 2744 PMC9329679__F1 Critical Appraisal of Filgotinib in the Treatment of Ulcerative Colitis: Current Evidence and Place in Therapy 10379 6773 7297 3716 PMC9333350__SF1 TLR9 signaling pathways 81622 4615 3665 54106 51135 3654 7189 PMC9334657__F2 Connecting Metabolic Rewiring With Phenotype Switching in Melanoma 4286 6319 948 2181 355 PMC9339493__F4 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) 11335 2539 693198 6774 100422982 3631 PMC9339493__F6 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) 6714 6774 1499 PMC9354322__F1 Pleiotropic roles of cGAS–STING signaling in the tumor microenvironment 115004 3661 10379 7297 6774 3716 PMC9354699__F7 Inhibition of KIR2.1 decreases pulmonary artery smooth muscle cell proliferation and migration 4087 4088 5111 PMC9357337__F3 ELIMINATOR: essentiality analysis using multisystem networks and integer programming 7474 8324 89780 8321 PMC9357337__F4 ELIMINATOR: essentiality analysis using multisystem networks and integer programming 7474 8324 8321 89780 PMC9358906__F6 Type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway 51421 25937 3661 3454 7297 3716 6772 6773 3455 PMC9359100__F7 Mfn2 is responsible for inhibition of the RIG-I/IRF7 pathway and activation of NLRP3 inflammasome in Seneca Valley virus-infected PK-15 cells to promote viral replication 9927 3665 114548 PMC9368823__F1 Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers 4040 4041 23642 8322 1499 6925 324 3170 2932 PMC9372658__F1 TAK-242 ameliorates epileptic symptoms in mice by inhibiting the TLR4/NFKB signaling pathway 7454 4280 7099 PMC9375293__F5 Targeting purine metabolism in ovarian cancer 1719 100124700 4524 2475 PMC9376094__F9 TDP-43 suppressing apoptosis by modulating ABHD2 in HCC 7038 11057 619501 PMC9386877__F1 Taste transduction and channel synapses in taste buds 29850 133060 255022 119395 PMC9394213__F2 Roles and functions of SARS-CoV-2 proteins in host immune evasion 57506 29110 3661 3665 3716 10379 7297 6773 PMC9395634__F3 MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes 9509 667 10491 1290 724022 140766 3475 170689 10962 55621 768222 PMC9396278__F7 Novel regulated network mediated by downregulation HIF1A-AS2 lncRNA impairs placental angiogenesis by promoting ANGPTL4 expression in preeclampsia 27086 100750247 51129 PMC9405053__F2 Celastrol: A Promising Agent Fighting against Cardiovascular Diseases 1499 2932 3162 PMC9409562__F1 Type I interferons during host–fungus interactions: Is antifungal immunity going viral? 6773 7297 5696 3431 57506 5132 7098 PMC9414313__F2 Exosomes: Small Vesicles with Important Roles in the Development, Metastasis and Treatment of Breast Cancer 2146 6774 4851 1499 27122 8650 PMC9424811__F5 RING finger protein family in health and disease 127544 55182 55072 3454 6045 165918 7297 6772 10379 3455 3716 6773 3437 9636 57674 27246 PMC9453641__F1 Gamble between oncolytic virus therapy and IFN 6773 10379 7297 3460 3717 6774 3455 PMC9454487__F1 Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics 4087 4088 6261 50507 PMC9455833__F2 Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets 2170 2173 2171 3569 3553 2167 PMC9459503__F6 Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer 8085 2194 47 PMC9460126__F7 Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation 114990 2475 8408 PMC9464948__F6 Luteolin induces pyroptosis in HT-29 cells by activating the Caspase1/Gasdermin D signalling pathway 114548 3553 79792 PMC9473615__F7 SAMD9 effect to DNA sensing pathway and proinflammatory responses 115004 3661 54809 PMC9477374__F6 EA activated EPO mediated Src signaling pathway and VEGF signaling pathway to promote angiogenesis in CIRI rat brain tissue 2056 2057 6714 PMC9479759__F5 Therapeutic potential of WKYMVm in diseases 3667 3553 928 6774 PMC9486121__F3 Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities 2932 1499 4040 4041 PMC9490146__F3 Targeting cellular senescence to combat cancer and ageing 115004 3661 29110 3458 3569 PMC9497767__F4 Epithelial–Mesenchymal Transition by Synergy between Transforming Growth FactorB and Growth Factors in Cancer Progression 960 2247 2249 80004 54845 9839 6935 PMC9500245__F6 Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients 50943 5272 3002 920 PMC9507402__F3 Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage 4163 114548 79792 PMC9511411__F7 Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy 11277 2213 114803 1777 PMC9515447__F4 USP13 in physiology and diseases 29110 8975 6772 57506 PMC9520664__F1 V-Set and immunoglobulin domain containing (VSIG) proteins as emerging immune checkpoint targets for cancer immunotherapy 11326 718 114548 5164 PMC9523788__F2 Innate and adaptive immune evasion by dengue virus 3454 7297 6772 3716 10379 PMC9533579__F3 Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review 4314 81029 1499 PMC9537693__F8 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid inhibits angiogenesis via modulation of vascular endothelial growth factor receptor 2 signaling pathway 387 7422 6774 595 PMC9545829__F7 miR‐378a regulates keratinocyte responsiveness to interleukin‐17A in psoriasis 4792 494327 6364 84818 1051 PMC9550596__F5 Henipaviruses: an expanding global public health concern? 7098 51311 51284 3661 3665 57506 7706 6773 6772 3454 PMC9550864__F2 Deregulated hyaluronan metabolism in the tumor microenvironment drives cancer inflammation and tumor-associated immune suppression 960 2821 8692 PMC9553391__F8 Anlotinib Benefits the APDL1 Immunotherapy by Activating ROS/JNK/AP-1 Pathway to Upregulate PDL1 Expression in Colorectal Cancer 3725 2353 2920 PMC9557975__F2 Activation of TLR4 by viral glycoproteins: A double-edged sword? 7099 929 114609 4615 3661 PMC9558365__F1 Wnt/Beta-catenin signalling pathway in Haematological Neoplasms 324 1499 2932 4040 4041 PMC9576519__F9 Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways 4908 8841 3065 PMC9578081__F5 11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing’s disease 6770 1583 1586 3284 1528 8644 6715 1589 3291 1585 1392 PMC9585453__F4 Systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury 283131 1499 2932 4040 4041 324 PMC9596219__F7 DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway 4254 4827 26528 PMC9596750__F1 Targeting the inflammasome in Parkinson’s disease 114548 324 10628 PMC9600545__F4 Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance 3458 3459 6772 920 3565 PMC9611148__F3 STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway 29110 115004 3661 PMC9617479__F2 Metabolic features of innate lymphoid cells 47 4609 2475 38 PMC9617731__F9 Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling 7097 7100 3665 51311 PMC98951__F2 Signaling pathways of IFNA, IFNB, and cytoplasmic dsRNA 7297 3716 6772 PMC9898571__F6 Osteoarthritis: pathogenic signaling pathways and therapeutic targets 6774 860 1499 4322 7422 9507 11096 PMC9898571__F7 Osteoarthritis: pathogenic signaling pathways and therapeutic targets 7048 7046 4087 4088 4089 4090 4086 4322 860 PMC1805736__F6 Pathways for synthesis of adrenal steroids 1583 1584 1586 1585 PMC1852792__F6 A hypothetical model for association of four subcomplexes in the FA core complex 91442 80233 29089 PMC2517664__F2 A simplified diagram of the key type-1 cytokine/receptor interactions relevant for immunity against intracellular bacteria, derived from published gene knockout mouse studies 3458 3459 3460 3594 3595 PMC2993603__F1 A tincture of hepcidin cures all: the potential for hepcidin therapeutics 9518 57045 3976 654 148738 164656 6774 PMC3149979__F1 A representative immune response pathway that leads to the disruption of viral release from the plasma membrane 3466 3661 3665 PMC3163738__F3 IFNA (type-I IFN) and IFN-λ (type-III IFN) signal through distinct receptor complexes, but activate the same intracellular signaling pathway 56832 3454 3716 7297 6773 6772 4599 3665 PMC3219632__F11 Suppressor of Cytokine Signalling-6 Promotes Neurite Outgrowth via JAK2/STAT5-Mediated Signalling Pathway, Involving Negative Feedback Inhibition 3479 3717 9306 PMC3271860__F7 THE ROLE OF IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS 3480 3479 3486 PMC3356660__F1 A model summarizing the results of the study in which the miR-301a molecule inhibits the PIAS3 enzyme, resulting in the promotion of the IL-6/23 receptor–STAT3 pathway and stimulation of Th17 differentiation 149233 10401 6774 PMC3478445__F12 Model of Stat3, Ascl1a, and Lin28a in inducing maximal Müller glial proliferation in the light-damaged zebrafish retina 79727 1839 6774 PMC3610375__F1 The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus 920 3565 3586 PMC3623586__F2 Schematic model of the regulation of intestinal homeostasis by the IL-22/STAT3 pathway in IECs 50616 6774 7297 PMC3656827__F2 Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review 3716 3718 6778 PMC3678929__F1 The insulin receptor (IR) with its two subtypes IR-A and IR-B, the insulin growth factor 1 receptor (IGF-1R) and the hybrid receptors (IGF-1R/IR-A and IGF-1R/IR-B) 3481 3479 3480 PMC3747576__F6 Urokinase pathway model 5327 5340 5054 5328 PMC3772111__F4 Computational models of the JAK1/2-STAT1 signaling 3466 6772 8651 3659 PMC3796519__F6 IL-27 Enhances the Expression of TRAIL and TLR3 in Human Melanomas and Inhibits Their Tumor Growth in Cooperation with a TLR3 Agonist Poly(I:C) Partly in a TRAIL-Dependent Manner 6774 6772 7098 PMC3866868__F2 Nodal pathway activity in the determination of L–R asymmetry 7044 4838 5308 PMC3958149__F2 Example of Janus kinase (JAK) inhibitors blocking cytokine signalling 3718 3716 3717 6772 PMC4110655__F2 Proposed mechanism of action of the erythroid regulator ERFE 2056 3717 151176 PMC4123481__F3 Role of STAT1 and STAT3 in Foxp3 expression and cytokine production in Tregs 6774 3458 6772 50943 PMC4317900__F3 Disease-specific mutations in T-cell large granular lymphocytic leukemia and natural killer (NK)/T-cell lymphoma 3600 3716 3718 3717 6774 PMC4337546__F7 Schematic diagram showing the cross talk between HCV and miR-373 inhibiting IFN signaling 3716 7297 6773 6772 PMC4383884__F5 Cisplatin response pathway 55244 6583 6582 PMC4590922__F4 The calgranulins, S100A8, S100A9, and S100A12, are secreted by cells of the myeloid lineage such as neutrophils and monocytes 6279 6280 6283 7099 PMC4618091__F2 Scheme of biosynthesis of bile acids and of traditional steroidogenesis 1593 1583 1581 1586 9420 80270 1589 1585 PMC4625546__F1 Is Retinol Binding Protein 4 a Link Between Adiposity and Cancer? 64220 3717 6774 9227 PMC4647060__F2 Schematic of CLCA1-driven MCM in human airways based on the current literature 1179 6778 5603 PMC4779130__F2 Signals involved in early granuloma formation 4318 6373 2833 PMC4810057__F2 The signaling network of JAK/STATs in IBD 3716 3717 3718 7297 6772 6773 6778 6774 6775 PMC4860032__F1 The metabolism, analysis, and targeting of steroid hormones in breast and prostate cancer 1586 6716 1588 PMC4881561__F4 Notch signaling pathway and the localization of NSD1, BAP1, PDE4DIP and ATP10B in mesothelial cells 4853 9659 23120 64324 PMC5013148__F9 Positive feedback regulation of type I IFN response mediated by IFNd-induced IRF3 and IRF7 activation in large yellow croaker 3661 3665 6772 6773 PMC5022012__F4 An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population 5566 8826 5577 3747 5576 5567 5568 9495 PMC5214941__F2 Proinflammatory role of extracellular interleukin (IL)-1A 10456 3554 7850 PMC5289527__F6 Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility 10333 3569 3383 PMC5390009__F1 Downstream signaling pathway of cytokines sharing the common G chain receptor: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 6772 6774 3718 3601 PMC5427230__F1 The theophylline metabolic pathway 1544 1571 1576 PMC5487703__F1 Trypsin-dependent pathological pathway in chronic pancreatitis 5644 11330 6690 PMC5500564__F3 Differential gene expression in the tamoxifen metabolism pathway 1576 1565 1559 PMC5500651__F5 Schematic illustration for signaling pathways of skeletal muscle growth regulated by let-7b 2690 10643 3481 PMC5610669__F1 Components of the insulin/IGF axis 3479 3481 3480 3482 PMC5629289__F2 IFNA2: The prototypic human alpha interferon 7297 6773 3716 6772 10379 PMC5701508__F4 JAK–STAT signaling pathway.Notes: (A) Specific ligands bind to membrane receptors, leading to dimerization, which promotes JAK activation and transphosphorylation, which in turn phosphorylates STAT, prompting its dimerization 3717 6772 6774 3569 3586 8835 PMC5714761__F3 Inhibition of stemness and EMT by IL-32θ 9235 6774 6935 648 PMC5785559__F8 Diagram of direct and alternative Runx2-Ihh regulation in chondrogenesis 860 3549 4745 864 PMC5839936__F2 Proteins significantly altered by torcetrapib associated with aldosterone synthesis or function 27122 285 5443 654 7040 7432 4879 5697 PMC6026738__F7 Hypothesis model 643 604 4055 10563 PMC6058924__F6 Pathway Studio Analysis of Proteomic Content of TFMPs at 6 Months in the Infarcted Groups Compared With Control Group Profile(A) Heat shock proteins (HSPs) associated with post-ischemic conditioning detected in CRT+BB–treated animals only 477 476 3310 PMC6210224__F11 IFN-λ3 rescued the RIG-I signaling pathway 6772 6773 7706 8638 3437 57506 3661 3665 282617 23586 282618 PMC6211194__F2 Simplified metabolic pathway of ∆9-tetrahydrocannabinol (THC), or ∆1-tetrahydrocannabinol, under the monoterpenoid naming system, in humans 1559 1576 54600 54575 54658 54659 PMC6266080__F4 LPL pathway and associated proteins 27329 338328 51129 64788 6400 4023 PMC6465609__F8 Schematic model of DHAV-1 inhibiting type I interferon signaling by hijacking the SOCS3 protein 3458 7098 6774 6772 9021 3661 4599 8638 3717 PMC6466196__F1 Schematic of IL-4 and IL-13 mediated signal transduction 3717 3718 3716 7297 6772 6774 6778 PMC6482218__F1 The role of molecular genetic markers in cellular stress response 3481 4153 627 4232 4306 2908 1831 2289 PMC6489558__F7 Hypothesis: after surgery, PTFs can stimulate surrounding hepatocytes to transform into a malignant phenotype, leading to hepatocarcinogenesis and tumor recurrence 3569 3570 6774 619501 PMC6509240__F7 Working model of polyI:C-mediated protection on pancreases from inflammatory injuries 3661 3553 2920 2919 PMC6526582__F1 Schematic representation of the three candidate genes and the four tag SNPs selected for this study in the IL-23 signalling pathway (SNPs rs3212227 and rs6887695 in IL-12B, SNP rs7857730 in JAK2, and SNP rs2293152 in STAT3) 3594 3717 7297 6774 PMC6591247__F8 FOXP1-induced CLRN1-AS1 suppressed pituitary prolactinoma by acting as a ceRNA to regulate DKK1/Wnt/Beta-catenin pathway 116933 27086 22943 PMC6627153__F4 PCOS–disease subnetwork 26 3133 3107 11006 3105 PMC6824075__F10 Working model for the SULF2‐LAPTM4B‐dependent autophagic pathway in HCC cells 55959 55353 619501 PMC6834135__F1 NK cell features in chronic HBV infection 3458 10219 960 PMC6885903__F3 The constructed network included a main connected component and 9 isolated nodes (DEGs) 3569 91543 4939 3434 8638 9636 5788 4938 6097 3394 64092 4599 6772 PMC6893479__F2 A summary of the main enzymes involved in the classic and alternative bile acid biosynthesis pathways 1581 1593 1582 9420 PMC6905088__F8 Relative P450 involvement in N-dealkylation pathways of terbinafine 1559 1544 1557 1565 1558 1555 PMC6909348__F2 CLCA1 on mucus production 6778 25803 1179 4586 PMC7068464__F7 Schematic diagram showing that upregulation of large-conductance and Ca2+-activated K+ (BK) channel activity in activated hepatic stellate cells (HSCs) exerts an antifibrotic effect through suppressing of the profibrotic TGFB1 signaling pathway 3778 4088 7045 7046 3717 6774 PMC7081179__F1 7Alpha-Hydroxylase and (25R)26-hydroxylase pathways of oxysterol biosynthesis 1593 9420 80270 1582 6718 1109 PMC7372973__F3 JAK-STAT signaling pathway 3458 3558 3569 3596 3716 3717 3718 7297 6772 6776 6774 6775 PMC7463613__F2 Notch signaling pathway in cancerogenic events 4855 4851 4854 4853 PMC7570361__F1 Biosynthesis of steroids in mammals 1583 3284 1586 6715 3293 8644 6716 8630 PMC7664983__F1 Action of Statins and Potential Interactions with Estrogen 1576 1577 1559 PMC7667157__F7 ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway 4851 440894 6935 PMC7857397__GA Neutralizing auto-Abs to type I IFNs underlie life-threatening COVID-19 pneumonia 7098 3665 3454 3455 PMC7893585__F9 Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway 10232 22943 23678 PMC7920342__F8 Schematic drawing of the role of Lhx6 in regulating root furcation development 26468 6423 8313 80326 1834 PMC7974515__F7 Graphic summary of this study 7046 8462 7040 PMC8017335__F3 Type 2 cytokines show diverse effect of NK cells activation 6775 6774 3002 PMC8066113__F2 Interactions between proteins, cells, and lentiviral infection for the GIMAP2 gene in PBNCs, as analyzed by the Pathway Studio program 3574 3575 168537 26157 920 PMC8233804__F1 Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus? 1594 1593 1583 1591 PMC8297769__F7 Summary and model of synergistic myocardial infarct size reduction by IPC in cardiac-specific SOCS3-deficient mice 2056 9021 6774 PMC8392322__F3 Ups and Downs of STAT Inhibition in Acute Myeloid Leukemia 3716 3717 6774 2322 PMC8518784__F9 Curcumin analog GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circular RNA zinc finger protein 83/microRNA‐324‐5p/cyclin‐dependent kinase 16 axis 55769 5127 6774 3717 PMC8598044__F4 Host Innate Immunity Against Hepatitis Viruses and Viral Immune Evasion 7297 3716 6773 10379 PMC8605525__F8 Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3 3717 6775 864 PMC8662121__F2 Type I interferon in the treatment of COVID‐19 3454 10379 3455 6773 6772 7297 3716 PMC8688647__F5 Network map of Elabela signaling pathway in physiological and pathological conditions 2768 187 408 409 PMC8804323__F1 FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling 1582 80270 1593 1581 9420 PMC9130030__F1 Realigning the LIGHT signaling network to control dysregulated inflammation 151888 4055 11126 PMC9185151__F1 InterferonA and its effects on cancer cell apoptosis 7297 6773 3716 6772 10379 PMC9263675__F4 Update on the pathogenesis of vitiligo 3601 3718 3716 3458 6772 3717 3627 4283 2833 PMC9294167__F1 Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance 6774 9021 3716 7297 3717 PMC9313337__F4 Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis 8835 9021 122809 9655 8651 6778 3716 3718 1154 3717 7297 6775 6774 6773 PMC9315936__F4 JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies 3717 64109 85480 PMC2949659__F1 Tamoxifen metabolic pathway 1565 1576 1557 1577 1555 PMC3010754__F2 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors 1576 1577 1565 1555 PMC6905088__F4 Metabolic model predictions for P450 catalyzed N-dealkylations 1544 1548 1555 1558 1559 1557 1565 1571 1576 PMC7872472__F1 Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses 7364 1576 1565 PMC1169236__F2 Metabolic reconstructions of the polyamine pathway based upon pam and sam analyses of poor-prognosis human NE tumors 4953 6723 6611 PMC1885811__F4 Web-accessible pathway navigator 401138 100187761 114609 6955 8717 23118 23586 7189 PMC2151384__F2 CON and NR samples; black/white boxes denote genes not detected on the human genechip with baboon RNA generated probe 5163 2475 253260 3091 1975 7248 6009 7249 1977 6774 3953 PMC2713123__F6 Early- and late-phase platelet aggregation regulated through PAR1 5091 4026 6010 55872 PMC2722767__F3 Application of SysPTM tools 5624 9350 7481 324 1499 387 9475 4089 4088 51701 PMC2759177__F3 Survival signals generated by PI3K and PLD that target mTOR 5728 5163 6009 7249 7248 572 4193 2932 PMC2773833__F3 Drivers of senescence and therapeutic opportunities in WS and HGPs 338340 7012 4280 7018 545 472 581 PMC2877959__F3 Uric acid transport and disease 4134 9429 4942 PMC2949446__F1 Luteolin and gefitinib regulation of EGF Signaling Pathway and Cell Cycle Pathway genes in PC-3 human prostate cancer cells 1950 2885 2002 6722 PMC2972986__F1 Biological processes known to be stimulated in an AHR-dependent and/or AHR-independent manner by the tryptophan photoproduct FICZ 196 405 1543 PMC2990745__F1 Examples of pathways shared by a signature hub from the Wang dataset and a signature hub from the Desmedt dataset 6235 6218 6133 6139 2056 8027 6154 6164 6201 6230 6207 847 2645 355 1616 929 PMC3039931__F1 Cytoplasmic tyrosine kinases in the activating signaling pathways utilizing ITAM-containing adapters 7959 6850 6010 7006 100124696 PMC3064560__F3 Analogue 3 also showed potent antiproliferative activity against the highly invasive non-small-cell lung cancer cell line CL1-5 with an ED50 value of 0.11 μM 1434 983 1104 9183 5901 22974 PMC3088996__F3 Regulatory role of ATM in cellular responses to DNA DSB repair 472 4193 637 995 993 672 9656 10111 4361 2177 1017 PMC3162452__F7 Schematic representation of intracellular pathways implicated in the regulation of cholesterol homeostasis and inflammatory response in human macrophages by IL-6 19 6774 3717 PMC316782__F1 Genetic pathways of sex determination in D 6955 367 8066 PMC3282946__F4 miR-23b and tretinoin, which was associated with this miRNA in thyroid cancer, shared the common target genes, ALDH1A1 and ALDH1A2 2475 3416 3091 6009 7249 1977 673 627 6955 7124 7186 355 1616 4149 929 23118 PMC3371005__F6 Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster 6232 3652 207 11181 5230 51701 287 23236 223 4897 5581 51196 10235 80852 9388 2769 57521 5786 5426 8525 2776 10125 7529 4023 9146 1956 6382 PMC3376488__F2 T-cell development and differentiation 6654 3603 6774 3569 114034 PMC3420877__F8 Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice 1950 1956 6714 PMC3469471__F2 Regulation of the human TRAIL gene 8772 581 637 PMC3600733__F2 The quantitative system pharmacology approach for a schizophrenia model is based on actual preclinical neurophysiology and human neuroanatomy 3791 100188864 759 847 PMC3648498__F3 Alzheimer’s disease pathway from the KEGG database 351 23385 3416 4023 572 842 836 8772 637 6622 177 100506742 22926 7124 840 PMC368161__F7 Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor 5756 9997 8139 2521 196 405 54623 6418 PMC3834778__F4 Shear stress reveals the mechanisms by which OA induces PICs and MMPs in human chondrocytes 7099 355 5347 1263 PMC3896626__F1 Interaction among differentially modulated genes in the cell cycle biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments 9126 5885 1874 4089 4193 6502 9184 699 5111 1017 1022 990 8318 4661 8317 10926 4998 23595 4999 5000 PMC4052186__F2 Cross-talk between mitochondrial metabolism and the IIS pathway is required to trigger the mitohormetic response in C 9798 5728 6649 PMC4088370__F3 KEGG Cell-cycle pathway 5885 699 9184 5111 1022 4661 6502 1869 PMC4180403__F1 Therapeutic Considerations in Treating HER2-Positive Metastatic Breast Cancer 7939 673 170 2475 PMC4254277__F2 Protein and Amino Acid Restriction, Aging and Disease: from yeast to humans 4553 2475 468 PMC4272512__F2 Immune, antioxidant and inflammatory targets that L-glutamine, L-arginine and BCAA are involved 2744 2936 23411 2475 3297 4843 PMC4303155__F2 MAPK signaling pathway showing the target genes of microRNAs 1610 4351 1950 6722 2316 1616 4149 929 51295 PMC4306509__F6 Human disease mutations in short linear motifs 4824 5728 367 1017 572 4193 596 2475 PMC4338781__F4 DMXAA modulates mTOR signaling pathway in A549 cells.Notes: A549 cells were treated with DMXAA 10 μM for 24 hours and the protein samples were subject to quantitative proteomic analysis 3643 3667 7248 7249 5091 253260 1977 1999 8408 9776 6194 1975 PMC4369255__F1 Synthesis and mechanisms of gaseous neurotransmitters in the relaxation of penile or other vascular tissues 4357 847 875 6010 PMC4452497__F9 UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1 2002 4286 1910 PMC4463188__F7 MEL-18 loss mediates estrogen receptor–A downregulation and hormone independence 9055 29843 6667 2099 PMC4470795__F4 Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis 9446 2947 27165 PMC4535548__F12 ERK/MAPK signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA 2885 1398 6714 5829 1793 4342 7444 572 1977 4772 6722 2002 PMC4549294__F14 UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFKB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFKBp65 Ser276 Axis 1956 7189 2002 2932 PMC4571721__F5 Chemokine signaling pathway map created based on KEGG pathways 3718 126669 2885 355 3702 387 1398 PMC4583851__F5 The differentially expressed profiles 27040 29760 6850 613 7189 331 8717 7186 3929 100187907 4513 7187 4049 4050 355 1616 4149 51295 51701 100187761 PMC4613458__F2 Signalling to eIF4E in cancer 253260 2475 1977 PMC4760771__F7 HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells 6608 6647 847 6648 PMC4889429__F2 MiR-155 on virulent (green) and avirulent (yellow) Mycobacterium species infection in macrophage 7097 7124 5569 PMC4945497__F2 Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A 1610 1950 1956 5894 2444 6722 4342 2316 2002 7186 355 1616 4149 929 23118 7189 51701 PMC4995918__F2 mf regulated mTOR signaling pathway in human DC 2475 3643 3667 5163 7248 7249 5091 6009 1975 253260 1977 6010 6194 1999 PMC5074855__F7 Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans 3084 27010 100034703 PMC5076770__F2 The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care 3082 1950 5728 6714 51527 324 2475 4513 6774 PMC5128196__F1 Huntington's disease pathway from KEGG database 140805 4478 25942 5978 3092 6667 6874 149998 836 6648 581 PMC5214967__F1 Biosynthesis of the lipid-linked oligosaccharide precursor for N-linked glycosylation and known defects in this pathway 5373 4351 79868 1798 22845 8818 8813 54344 56052 201595 3703 1603 91869 79087 10195 29929 84920 PMC5242433__F6 Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial 4089 4193 6502 9184 5111 1022 1017 4661 8318 10926 23594 PMC5285325__F3 Nuclear Dynamics of Heterochromatin Repair 79677 23137 5893 5371 2638 PMC5291375__F7 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets 8027 2670 23385 2475 7248 6009 1975 759 5894 5879 613 6850 930 5934 5728 572 5266 256933 4193 PMC5341249__F2 Assays for the identification of G protein signalling pathways using the constitutive activity of an orphan GPCR 84188 387 6722 PMC5386675__F3 Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin 10296 23304 8975 6626 7073 4967 4300 7072 10752 56852 55920 6596 54840 6654 641 10847 4287 56931 10923 6610 2067 7507 57697 2585 11200 7508 8554 6138 545 9133 1111 1643 5887 5886 2072 2073 2071 2068 PMC5403663__F2 Enrichment of gene expression changes (p < 0.05) shared by the TCF4 small interfering RNA (siRNA)#1 and TCF4 siRNA#2 conditions in the “cell cycle” KEGG pathway (p = 0.006, Bonferroni-corrected) 9126 5885 4089 4193 9184 991 699 5111 1017 1022 6502 6351 10926 PMC5432965__F2 Microarray profiling of 467 human GBMs discovered that polo-like kinase 1 (PLK1) was highly expressed in these tumors and that it clustered with the proliferative subtype 5426 9748 991 324 9126 PMC5488057__F1 Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks 7412 4512 4353 3479 PMC5501956__F3 KEGG MAPK signaling pathway (KEGG ID: hs04010) 4803 4351 2444 6722 4763 2316 3727 7124 7186 355 1616 4149 4208 929 23118 7189 51295 51701 PMC5507646__F1 BRAF mutations in the context of mitogen‐activated protein kinase (MAPK) molecular alterations 1956 6098 3845 673 PMC5522110__F3 Subset of microRNAs defining the side population of a human malignant mesothelioma cell line 1950 867 7039 367 1398 685 3725 1839 126669 9542 2475 572 145957 PMC5541935__F2 Comparison of Biomarker Expression between Proximal and Distal Colorectal Adenomas: The Tennessee-Indiana Adenoma Recurrence Study 1499 1956 1950 7046 4040 6714 94234 324 2475 595 7018 PMC5558921__F2 BER pathway is essential in the nervous system 7515 3980 55775 11284 5423 3978 5426 2237 5111 PMC5629631__F23 Multiple modes of AOAA’s action in cancer cells 875 847 2805 2806 PMC5644640__F1 Summary of potential beta adrenergic signaling pathways in canine hemangiosarcoma and human angiosarcoma 6714 4318 5743 PMC5655319__F1 Update on the therapeutic significance of estrogen receptor beta in malignant gliomas 7247 1401 2475 2002 6667 5728 1958 PMC5660709__F5 Mycobacterium tuberculosis interferes with phagosome maturation 948 8411 26276 5524 7097 7405 6774 PMC5679168__F1 Contribution of BBB breakdown and dysregulated BBB transport to AD pathophysiology based on findings in animal models, as shown in and 8301 4036 7436 84879 PMC5713305__F2 Nuclear factor erythroid 2-related factor 2 (Nrf2) regulatory pathway 4094 6256 9817 2730 2729 5052 3162 2235 PMC5735114__F2 Distribution of differentially expressed genes in astrocytes following hypoxia+ hypothermia vs 2619 6608 51684 7546 51715 2932 51701 147111 9350 324 4088 25805 50964 6500 8454 9475 387 27130 PMC5743386__F9 Proposed model shows that MTH-3 induces G2/M phase arrest, autophagy and apoptotic cell death (death receptor/mitochondrial pathways and ER stress) in human breast adenocarcinoma MDA-MB-231 cells 4504 983 891 9474 10533 9140 8772 PMC5821264__F3 Regulation of Signal Transduction by DJ-1 5163 5728 7428 7249 7248 2932 6009 4193 664 3098 PMC5866379__F14 Cartoon showing hypothetical activation of CFTR by cigarette smoke extract via prostanoid and store-operated cAMP signaling pathways 1080 4512 4513 6786 PMC6015651__F1 Domains and functions of MCPyV T antigens 4149 4610 4609 1977 5981 54106 PMC6073630__F3 Disruption of ncRNA Networks in Cancer 27161 1871 23369 604 55384 729 5728 999 129563 27343 11201 2308 PMC6109480__F1 PD-1/PD-L1 signaling and reprograming in T cells 324 5728 3932 27040 2475 10125 2695 PMC6239977__F2 Calcium-calmodulin-calcineurn-NFaT-DYRK1A pathway to human beta cell proliferation 1859 1028 983 2305 847 PMC6261508__F1 MTOR pathway in treatment of epilepsy: a clinical update 8131 10641 9681 5728 7248 7249 2475 253260 6009 1977 92335 PMC6299648__F5 Oxidative status and leptin signalling pathway in human mammary epithelial cells 3717 6774 4513 PMC6329812__F2 The stress adaptive processes induced by mutant p53 trigger positive loops feeding its own accumulation in cancer cells 387 3297 4193 10013 PMC6336458__F1 Molecular mechanisms of viral oncogenesis in humans 102 5163 2305 9794 613 7099 958 3654 324 7189 PMC6341905__F1 TGF and RBM5 signaling cascade 7039 1950 10181 572 581 5728 PMC6433075__F10 Proposed model of glycogen phosphorylase regulation by epidermal growth factor receptor in human Kit 225 T cells 5894 2885 1956 PMC6503994__F8 Potential role for TXNIP in HG-mediated RPE dysfunction 10628 114548 6120 PMC6592250__F5 Coordinated interactions between glycolysis, citrate cleavage enzyme, and glutaminolysis for the fatty acids biosynthesis in growing tumor cells 23530 3417 355 PMC6600647__F4 Uncovering the assembly pathway of human ribosomes and its emerging links to disease 6125 6135 23212 PMC6612049__F1 Mechanisms of ionizing radiation sensitizing and resistant effects in various subtypes of breast cancer and irradiation-induced apoptosis 7323 1956 1499 581 596 5888 672 3934 2475 PMC6689979__F2 Subcellular compartmentalization of sphingolipid metabolism 6497 6696 2531 PMC6705839__F3 System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells 9126 5885 4087 4088 4089 2932 4193 6502 9184 699 991 5111 993 1022 1017 5347 999 1869 8317 10926 4999 1874 983 4661 8318 23595 5000 PMC6743755__F3 Petri net–based model of the human DNA base excision repair pathway 266710 5111 2922 11284 2237 5423 3980 3630 PMC6748125__F6 Erythropoietin (Epo) binds to the Epo receptor (EpoR) to activate erythroid-specific gene transcription (EpoR, globins, glycophorin A (GPA), and miR-144/451) by GATA-1, resulting in hemoglobin (Hb) production 2056 2057 8877 2475 8408 9474 9776 9140 PMC6816781__F6 Signaling pathway regarding the cell cycle regulation in human bladder transitional carcinoma/BFTC-905 cells after stimulated by LSS 4047 4090 4086 595 1019 1021 7465 898 1017 983 890 PMC6895093__F15 Apoptosis adapted from KEGG (ID: hsa04210), the know targets were signed in red; (B,C) the insulin signaling pathway adapted from KEGG (ID: hsa04910) the predicted targets and other human proteins were signed in red 6964 472 355 3630 7249 572 9381 6009 PMC7040013__F4 Pathway analysis reveals predicted gene targets enriched in predominately nervous system signaling pathways for focal (A) or diffuse (B) injury cohorts 1387 3845 5899 6237 6655 6654 2885 PMC7049903__F5 Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia 183 1636 59272 367 PMC7094317__F2 Cell polarity pathways are targeted by diverse human viruses.Interplay between the Scribble (SCRIB), PAR, and Crumbs (CRB) complexes is central to the control of cell polarity 10207 79633 998 1739 23513 324 3050 PMC7216841__F1 Latency reversing agents induce HIV‐1 provirus replication by diverse mechanisms 5728 1431 23476 51574 56257 1025 PMC7225374__F11 Core apoptotic pathway and its regulation by miRNAs in THP-1 cells exposed to the lower dose of CdS QDs 355 11124 23411 998 8772 5728 207 572 8739 638 90427 637 407047 581 PMC7275233__F2 Curcumin-induced apoptotic pathway in human 8772 472 545 995 993 6955 PMC7277093__F12 Multiple modes of AOAA’s action on H2S producing pathways and other transaminases in cancer cells 875 847 2875 2805 2806 PMC7312818__F3 Role of miRNAs in the host–pathogen interaction 59272 100423038 100616245 1080 4615 7189 920 PMC7337897__F6 MDM2 regulates E2F1 synthesis during EBNA1 mRNA-induced translation stress 1019 4193 1017 983 PMC7409586__F3 Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency 2638 6401 4174 PMC7422677__F8 Index and biological spectrum of human DNase I hypersensitive sites 55422 2534 3932 7054 100885775 355 3505 6775 3558 238 907 100187761 PMC7430027__F7 KEGG pathway classification map of the experimental group 7124 7448 7450 960 255743 1101 948 961 2475 7249 2885 5066 5879 6850 930 5934 5550 572 596 5728 6256 128071539 759 4193 PMC7461761__F1 Evolutionary Origins of Programmed Cell Death Signaling 8772 841 317 197259 11035 8717 79792 23212 326340 PMC7467727__F5 MTOR regulation of oRG morphology 2475 1356 998 PMC7497193__F1 Two major signalling pathways implicated in melanoma 57105 1956 3815 2885 4763 5332 2475 PMC7527140__F2 Deduced sterol biosynthesis pathways in Symbiodiniaceae 3652 10682 1717 PMC7558805__F6 Sphingolipid biosynthetic pathways: 1442 5004 5005 PMC7704407__F4 Proposed pathways of how cAMP and Ca2+ interact and result in increased AQP4 expression via Gs and Gq/11 in the pathology of HE during ALF 59341 361 551 PMC7744569__F4 Summary of metabolic engineering performed to increase fatty alcohol production in S 5192 25913 128 PMC7838852__F1 Diversity and versatility of p38 kinase signalling in health and disease 5608 7535 10454 1843 PMC7848376__F5 A, On the left, HIF‐1 signaling pathway (modified from KEGG hsa04066), showing genes targeted by miRNAs (n = 16) involved in its modulation 572 3558 8772 581 2021 PMC7852150__F1 Metabolic features of hPSCs 29968 2194 50 PMC7912776__F1 Genetics of extreme human longevity to guide drug discovery for healthy ageing 3479 4040 4041 3643 3667 2885 2932 5163 7249 7248 51256 6009 PMC7913953__F3 Over- and under-expressed genes are enriched in the human cell cycle pathway 9126 10274 10735 4089 4193 6502 991 699 5111 1022 1017 5347 990 4661 10926 3630 PMC7999907__F1 Degradation of p53 induced by E6 variants of human papillomavirus (HPV) 16 favors metabolic reprogramming 3643 3099 57103 PMC8097364__F2 Genome diversity and instability in human germ cells and preimplantation embryos 545 2178 2175 80233 55120 57697 675 672 641 79677 6741 PMC8126563__F3 Protein kinase CK2: a potential therapeutic target for diverse human diseases 6418 3831 6500 PMC8136213__F7 Symbiotic relationship between Caenorhabditis elegans and members of its microbiome contributes to worm fitness and lifespan extension 4860 192668 5163 6446 4550 6053 2327 PMC8235403__F14 Orthosiphon stamineus Proteins Alleviate Hydrogen Peroxide Stress in SH-SY5Y Cells 2288 3240 9536 PMC8257499__F5 Rare copy-number variants (CNVs) in spina bifida (SB) cases participate in SB-relevant pathways and affect various aspects of one-carbon metabolism 501 10677 1757 100187761 4974 23743 PMC8436938__F13 Siberian fir terpenes extract Abisil on antioxidant activity, autophagy, transcriptome and proteome of human fibroblasts 4999 23595 5000 23594 2932 1021 1019 6502 1874 4089 1017 1869 990 4193 5111 1022 8317 8318 10926 993 983 9184 699 5469 9126 10274 10735 991 999 PMC8450533__F4 RhoA/ROCK-YAP/TAZ Axis Regulates the Fibrotic Activity in Dexamethasone-Treated Human Trabecular Meshwork Cells 638 27040 1610 4151 1398 4763 5900 5863 3416 7410 5810 6010 572 998 790 PMC8472231__F8 Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells 126669 2885 5728 6010 7408 3611 1398 998 572 2002 PMC8588809__F2 Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome 5091 9776 8408 1977 3091 7249 7248 6009 3643 1975 5163 6010 6194 1999 PMC8647113__F10 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases 7124 355 929 2885 8717 51083 7189 7186 1616 23118 351 57136 2147 4284 4149 PMC8647113__F11 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases 126669 2885 3702 57580 1794 998 572 8205 29984 PMC8790028__F3 Opioids Regulate the Immune System: Focusing on Macrophages and Their Organelles 1234 54106 4615 PMC8888693__F1 Using a Systems Approach to Explore the Mechanisms of Interaction Between Severe Covid-19 and Its Coronary Heart Disease Complications 54677 4282 7412 7054 3479 7124 4099 1636 PMC8902048__F1 Rotenone Modulates Caenorhabditis elegans Immunometabolism and Pathogen Susceptibility 11016 22809 2475 PMC9025423__F1 Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia 2189 2187 57697 2178 2175 55120 55215 2188 2176 2177 PMC9033871__F3 Inflammation and atherosclerosis: signaling pathways and therapeutic intervention 4049 7097 7096 3654 51135 23118 10454 114609 4615 255738 114548 3661 7187 29110 3665 79792 PMC9297570__F3 Putting human Tid-1 in context: an insight into its role in the cell and in different disease states 324 4593 55364 PMC9322892__F2 Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic 114548 22861 59067 3458 920 50943 1401 8864 90865 PMC9338538__F3 Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions 7450 718 759 PMC9359989__F6 Ingenuity pathway analysis of synaptosomal miRNAs in AD 100313837 23118 284131 5970 PMC9454636__F1 Drosophila as a Model for Human Viral Neuroinfections 5649 4615 23118 8772 51135 8717 7189 257397 10454 7186 7187 3656 3654 3665 115004 29110 PMC9499815__F8 Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism 3099 3939 9097 387 7251 PMC1237009__F1 Will the Real Cholesterol Transporter Please Stand Up 29881 64240 64241 7038 39 375 19 PMC1796761__F1 Pathway of double-stranded break repair by homologous recombination and the factors involved 9156 675 5893 PMC1855986__F9 ATM-Mediated Transcriptional and Developmental Responses to Gamma-rays in Arabidopsis 545 472 7465 54205 PMC1948012__F10 Action for AICAR in human leukemia ALL cells 5728 5163 7249 7248 6009 2475 PMC22365__F5 Evolutionary conservation of the DNA damage and the replication checkpoints 472 545 1040 PMC2597498__F4 TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway 6009 619537 1977 PMC2600462__F5 Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions 1956 6009 2475 1977 7249 6502 PMC2635018__F1 Amino acid transporters and nutrient sensing mechanisms 6009 7248 7249 8471 3667 8660 5728 PMC2688755__F2 Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen 6996 545 472 6188 3014 675 2177 5426 5111 2237 338340 PMC2698645__F2 Simplified schematic representation of the interaction between the mTORC1 and ERK1/2 signaling pathways following muscle contraction and/or insulin stimulation 7248 7249 6009 6194 29904 1938 PMC2754694__F1 Transcriptional regulation of human CYP17 25942 6714 6670 PMC2764635__F7 Experimental results of Rap1 pathway knockout from Falco et al 10818 2885 2549 5979 PMC2783576__F2 Mitotic removal of cohesin in humans: In humans, cohesins (pink) are removed from chromosome arms in prophase in a Plk1-dependent pathway 699 324 9184 5347 9126 PMC2863124__F1 DNA damage and replication checkpoints in various organisms 472 2922 1040 PMC2898064__F10 Views of predicted functional interactions 355 958 356 8738 PMC2929731__F8 cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways 7432 1080 89797 362 360 361 PMC2945950__F2 ERBB signaling pathway 1950 367 685 3725 126669 2475 100653365 145957 PMC2947220__F8 Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer 355 1017 406900 PMC2948292__F1 Potential roles of BLM and RECQ5 in sister chromatid exchange regulation 2152 641 5888 PMC2991480__F5 FC-66 expression of the Ingenuity NFKB Signaling canonical pathway 650 652 1950 4803 7039 4049 100187907 114609 3932 7535 7334 7335 5336 PMC3045854__F1 Memory genes identified in model systems overlap with genes identified in human mental retardation 4703 7039 1950 2885 4763 7248 7249 2475 4983 1363 6010 PMC3066048__F1 Complementation of Saccharomyces cerevisiae coq7 Mutants by Mitochondrial Targeting of the Escherichia coli UbiF Polypeptide 27235 51805 51004 84274 PMC3078731__F3 Central prostate cancer-related processes and their miRNA-mediated regulation 4193 6010 5728 PMC3084021__F1 Conservation of the RB and Hippo signaling pathways in humans and fruit flies 1019 1017 4172 4485 26524 PMC3092273__F1 Complementary signaling pathways activated in human cancer cells 2475 3479 5728 5163 7249 7248 6009 5337 4609 PMC3120937__F1 Signalling pathways in oesophageal adenocarcinoma 1956 4040 4041 324 1499 2475 PMC3154417__F2 mTOR signaling pathway 5728 7248 7249 2475 6009 6010 PMC3197200__F2 Intracellular signaling pathways regulating growth 3479 2261 3480 5728 4485 1977 PMC3205804__F2 From a physiological point of view, exfoliated epithelial cells resulting from nutritional induction or mild stress are in anoikis by activating a survival mechanism partly using the molecular paths of macroautophagy 55364 3667 2475 6009 9776 PMC3281623__F9 Toxoplasma acquires fatty acids through a complex network of synthesis and uptake 6924 6923 6921 1674 PMC3295657__F6 Pathway model for interleukin (IL)-1A and tumor necrosis factor (TNF)-Alpha-induced inhibition of human skeletal muscle cell (HuSKMC) differentiation 238 4088 4087 1386 PMC3312932__F2 Regulation of the human catalytic subunit of telomerase (hTERT) 1874 4088 3626 6667 1869 993 4089 7015 3481 4335 10664 4193 2475 PMC3337163__F1 Breaking up is hard to do 6790 5898 983 10928 PMC3389589__F1 Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target 5728 7249 6009 2475 1977 PMC3426219__F2 Chondroitin sulfate proteoglycan 4 (CSPG4) Signaling Pathways 1464 4313 4286 1003 3082 PMC3434988__F1 Hepatocyte growth factor (HGF)–cMET axis signaling network and ongoing targeted therapy strategies 3082 1956 57521 54433 PMC3477860__F4 Schematic diagrams of the role of STAT1 in antimycobacterial, antiviral and antifungal immunity 3594 7297 2580 149233 3595 958 3659 3394 3716 3717 6772 7098 7187 3661 6773 10379 64170 84818 50615 6774 PMC3545927__F6 High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome 1855 4090 4086 4087 4088 5163 4089 324 2932 238 5045 2626 1386 PMC3549674__F1 New and emerging treatments for estrogen receptor-positive breast cancer: focus on everolimus 3480 1956 6714 5728 64798 7249 7248 595 2932 6009 PMC3578363__F4 Targeting ubiquitin-dependent degradation of CDK inhibitors 1017 8454 6500 6502 100187761 PMC3585432__F1 The Drosophila Hippo pathway 7791 122786 154796 2147 4485 26524 860 PMC3681875__F7 Novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair 672 81620 1017 PMC3711071__F1 Function and regulation of AMPK leading to tumor suppression 7248 7249 8408 9706 7508 2475 PMC3749846__F3 Role of DMP1 and its future in lung cancer diagnostics 1019 4609 595 3725 1758 PMC3791178__F1 The Autophagy Pathway by Human Tumor Viruses 64422 2475 9140 9474 920 PMC3830643__F2 Lipid Synthesis in Protozoan Parasites: a Comparison Between Kinetoplastids and Apicomplexans 6924 6923 6921 1674 PMC3847167__F4 Lines/LINS plays a putative dual role in WNT canonical pathway 474168 7471 1499 PMC3855612__F4 Human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone 3667 5728 5163 2475 253260 7248 6009 7249 64798 PMC3976626__F8 By simultaneously inhibiting CBS activity and inhibiting GOT1, a key enzyme of the malate/aspartate shuttle, AOAA acts as an inducer of ‘synthetic lethality’ in cancer cells 875 2805 2806 PMC4088370__F4 KEGG Apoptosis pathway 7939 8772 8717 7186 637 4803 PMC4106090__F1 N-glycosylation pathway 4335 7841 23193 2592 79694 PMC4189449__F1 Pathway where human papillomavirus (HPV)16 E5, E6 and E7 oncoproteins regulate cyclooxygenase-2 (COX-2) expression associated with the cervical carcinogenesis 1956 8841 3725 PMC4196647__F2 E-cadherin on RTK signalling 999 1956 6772 2066 4193 PMC4222256__F8 Supposed mechanism of EVE-induced EMT 10855 253260 55615 64223 7249 7248 2475 6009 PMC4273448__F7 The structure-function relationships of IRAK-M based on this study 1283 4615 7189 PMC4298491__F3 Signalling of the PI3K/AKT/mTOR pathway and relevant drugs that target each of the components of the pathway 1956 613 5728 PMC4300671__F1 Working model for rotavirus cell entry into MA104 cells 81 998 387 8411 4074 PMC4324580__F5 Proposed mechanism of action of glycyrrhetinic acid (GA)-induced G1-phase arrest in non-small cell lung cancer (NSCLC) cells 83939 1021 1019 1017 6839 1719 5111 22926 PMC4357780__F3 iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies 1311 7975 847 3458 PMC4384471__F4 Induction of interferon (IFN) and its antagonism by viral proteins 115004 57506 3661 3665 PMC4514180__F2 Roadmap of peptide vaccine versus peptide mimic strategies 4280 9241 7054 PMC4535548__F13 NFKB signaling pathway was regulated via ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA 920 3932 7186 6908 PMC4535548__F14 PI3K/AKT and HSP90 interacted with ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA 3611 5728 5163 4170 7248 572 4193 7249 6009 79923 2475 1977 PMC4588138__F1 Schematic of opportunities for host-directed therapies modulating eicosanoid balance 4512 4048 7124 PMC4699279__F1 Gliadin peptides pass through the epithelial barrier paracellularly or transcellularly 2833 1956 4615 324 PMC4728196__F1 PI3K pathway with respective PI3K inhibitors 5728 5163 2475 572 7249 4193 PMC4790586__F1 Signaling pathways involving the molecules reviewed 1719 1019 595 4609 7291 648 2146 6909 3726 4193 7528 PMC4888354__F3 The mechanisms of action of ANG Secreted ANG undergoes receptor-mediated endocytosis from the cell surface to the inside of the cell where it accumulates in the nucleoli under growth conditions or in the cytoplasm under stress conditions 5350 4553 4193 6050 10468 5359 PMC4981357__F7 Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity 6774 10054 10055 PMC5056850__F2 Signaling via PINCH: functions, binding partners and implications in human diseases 3611 8440 6251 PMC5291375__F3 Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets 5728 572 2272 4118 PMC5309818__F3 Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions 391051 646625 2525 PMC5413367__F1 Targeting molecular pathway 2549 6714 1956 1950 PMC5445269__F3 Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans 65018 6446 208 207 5163 6009 PMC5523853__F1 Key components of the stress response signaling network in C 3480 9798 5728 3281 5170 5163 6794 6446 23411 4087 6497 253260 2475 6009 3725 2002 3091 2885 1956 1950 PMC5540363__F1 Oxygen regulation of ESC metabolism and epigenetic landscape 6657 79923 2638 10020 PMC5572260__F4 Signaling in human glioblastoma cell lines after treatment with vascular endothelial growth factor (VEGF), irradiation and axitinib 998 9261 5178 PMC5610669__F4 Crosstalk between IGF-1R and other RTKs/steroid hormone receptors 3480 1956 238 3643 3667 5163 367 2475 PMC5611871__F1 AMPK-activating drugs that reduce cellular ATP levels, such as the antidiabetic metformin, promote tumor suppressive actions in a LKB1-dependent manner 7248 5728 7249 6009 2475 64223 64798 PMC5622249__F6 Schematic diagram of hypothetical mechanisms underlying chloroquine enhances sensitivity to cisplatin in ovarian cancer cells 2475 9474 10533 PMC5727901__F1 Cyclin–CDK complexes and the cyclin D–CDK4/6–p16–Rb pathway in the cell cycleThe cell cycle is regulated by cyclins and checkpoints, with different cyclins (and cyclin–CDK combinations) and checkpoints acting at 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Protein-protein interaction network of predicted target genes of hsa-miR-203 100 8139 5548 6678 1356 51596 PMC6105893__F10 Role of cFP as a virulence factor while in the host and also as a signal to induce expression of genes to protect the pathogen 5199 6418 6098 PMC6109817__F2 Cross-talk between oestrogen (ER) and epidermal growth factor receptor (EGFR)/insulin-like growth factor 1 receptor (IGF-1R) signalling pathway and cyclin-dependent kinase (CDK)4/6 function 3480 2475 1019 PMC6115855__F7 Anti-cancer mechanism of the PEC treatment in both AGS and MKN28 cells 331 2475 995 1977 983 PMC6133308__F1 KEAP1-NRF2 pathway is altered in human lung cancers.Schematic of KEAP1-NRF2 pathway under homeostatic conditions (left), oxidative conditions (center) or synergistic conditions, for example in a cancer cell (right) 2932 8452 4094 9817 PMC6205166__F4 Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats 847 23118 10454 5447 257397 6774 3725 PMC6273859__F7 Possible signaling pathways for tetrandrine-induced apoptosis in NPC-TW 076 human nasopharyngeal carcinoma cells 355 581 637 PMC6348061__F2 Simplified diagram of the acetylcholine (ACh)-signaling pathway in human lung cells 1103 43 590 PMC6372189__F3 A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster 247 239 246 240 PMC6397284__F4 Promoter hypomethylation of genes involved in myogenesis, structural dynamics of muscles and CDC42 signaling 89846 2245 998 PMC6468398__F1 Biogenesis and function of ribosomal RNA-derived fragments 27161 7078 26523 PMC6521789__F6 Mammalian PUFA synthesis pathway showing the n-3 PUFA pathway and the n-6 PUFA pathway, including the enzymes responsible for the elongation and desaturation steps 65057 9415 3992 6924 PMC6627106__F4 Four branches of MOB control 81532 4485 85369 57464 9113 26524 4361 10111 PMC6635480__F1 Targeting pathways and molecules in the treatment of NMSC 6608 51684 1956 5266 2475 4193 572 PMC6683960__F1 Gold nanoparticles-loaded hydroxyapatite composites guide osteogenic differentiation of human mesenchymal stem cells through Wnt/Beta-catenin signaling pathway 2932 324 1499 860 PMC6953121__F6 Schematic representation of the molecular interplay between S1T-dependent ER Ca2+ leak, ER stress, BAPP processing, and neuroinflammation likely contributing to AD setting and/or progression 83939 351 23621 468 PMC6962519__F3 Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1)-independent regulation of protein translation 7249 1938 6009 2475 64798 PMC7017275__F2 Identified downstream targets of YB-1 in gynecological cancer 7852 999 1956 PMC7109607__F3 SOX2-expressing tumor cells as potential therapeutic targets 6657 6469 324 PMC7294112__F7 Schematic to represent the proposed molecular events in DHL‐induced apoptosis in laryngeal carcinoma 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Future Approaches 3652 100507436 1021 1019 672 PMC8144889__F3 Regulatory control of the Na–Cl co-transporter NCC and its therapeutic potential for hypertension 130497 907 26249 8452 65125 PMC8147357__F1 mTOR Signaling in Metabolic Stress Adaptation 6009 5163 7249 1977 5728 253260 PMC8193087__F1 Selenium Transport Mechanism via Selenoprotein P—Its Physiological Role and Related Diseases 6414 84890 118672 875 407 PMC8231510__F2 CUT Domain Proteins in DNA Repair and Cancer 27244 143686 9817 2885 5879 50507 27035 5728 5163 PMC8300636__F1 Relevance of Plant-Derived Se Compounds to Human Health in the SARS-CoV-2 (COVID-19) Pandemic Era 1431 867 3240 118672 4397 51091 PMC8329661__F3 Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? 5728 2475 1956 3845 2695 PMC8385607__F5 Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease 1384 1051 5292 2475 PMC8472231__F9 Expression Profile of New Gene 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7494 22926 3606 PMC1351175__F11 Proposed Receptor Ck – dependent signaling pathway involved in hTERT gene regulation at the transcriptional level 338 5091 3949 6667 PMC22464__F5 Metabolic reaction network analyzed from the human erythrocyte containing 29 metabolites and the related 51 fluxes (37 internal and 14 exchange fluxes) 7083 2597 637 PMC2453072__F3 The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant 117159 7374 1854 PMC2570554__F4 Anti-apoptotic mechanism of survival and growth of serum-starved 5637 human bladder carcinoma cells 1839 3082 867 6714 572 PMC2583357__F3 ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY 5728 1431 7248 PMC2603035__F3 Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease 650 7040 5053 PMC2633485__F8 Proposed mechanism of PDGF signaling in the lens 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SLE CD4+ T cells.A 1786 51162 970 920 7018 10125 PMC3205681__F2 Post-translational modifications (PTMs) of transcription factors 8473 6955 6717 6007 10724 389692 50853 PMC3245622__F1 PI3K/Akt signaling pathway is involved in several human cancers 5728 572 2475 PMC3329512__F7 The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism 5091 5132 23152 355 PMC3346111__F7 Overall scheme of hypothetical effect of endocannabinoid signaling in human melanocytes 7442 4286 5443 4157 PMC3383804__F5 HCMV management of the PI3K/AKT/mTOR pathway 6009 7248 253260 7249 1977 PMC3414739__F2 LECA Rabs and their proposed functions 23011 53917 22931 51715 10981 51552 9364 PMC3429879__F1 Therapeutic Mechanisms of Treatment in Cervical and Vaginal Cancer 100187761 1633 7083 7084 4860 PMC3509687__F1 Impact of the cellular restriction factor APOBEC3 (A3) on human immunodeficiency virus-1 (HIV-1) replication 4099 80328 545 472 PMC3521040__F2 Molecular mechanisms of activation, amplification, regulation, and evasion of the AP C3 convertase 718 1356 2271 1604 4179 7415 85477 PMC3684427__F5 The regulation of clot formation (colored entities) 7035 7018 324 PMC3717802__F6 Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer 3667 2695 6009 2887 PMC3722318__F1 Autophagy master regulator TFEB induces clearance of toxic SERPINA1/Alpha-1-antitrypsin polymers 3569 5265 7942 4792 PMC3787301__F4 The physiological and metabolic landscape of Melainabacteria 9049 11113 7851 PMC3894810__F5 New insights into host–pathogen interactions during Entamoeba histolytica liver infection 1356 93979 3383 PMC3943598__F1 Molecular mechanisms in Carney complex (CNC) and McCune-Albright syndrome (MAS): Receptor activation (ligand binding) makes GsA to exchange GDP to GTP, GsA is then freed from the BetaG dimer and activates adenyl cyclase (AC) 2778 4088 2580 1499 PMC4007761__F2 Secretory pathway components studied in zebrafish and implicated in human diseases 60684 6396 22872 6399 9871 83696 10427 51128 9632 PMC4088370__F2 KEGG MAPK signalling pathway 3273 4803 4763 355 929 23118 51295 PMC4106090__F3 GPI anchorage pathway 84720 5281 54872 93183 23556 9487 5283 9091 90459 284098 PMC4136892__F7 Signaling pathway regulation in human schwannomas 5159 2621 558 4771 PMC4157753__F1 Retinal degeneration in animal models with a defective visual cycle 6120 6121 64220 9227 24 PMC4535548__F11 EIF2 signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and the pathways were analyzed using IPA 1998 83939 100187761 PMC4542009__F1 Tumor Angiogenesis 7428 6714 1956 2064 5281 8829 8828 PMC4550685__F1 Intracellular pathways of factors regulating adipogenesis, lipogenesis and lipolysis in the adipocyte 3643 204 6774 5140 355 7038 4023 2638 PMC4593375__F1 The primary epidermal growth factor receptor (EGFR) signaling pathway 1956 2885 5728 2475 PMC4613973__F8 Working models for the failure of PRL-PRLR-JAK2-STAT5 signaling to activate proliferation in adult human Beta-cells 5618 5617 3717 PMC4661887__F4 Mechanism of action of soy peptides in HepG2 cells 253260 3949 2475 PMC4703318__F1 Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach 11124 1499 55294 3091 331 PMC4945497__F1 Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A 8027 10379 2475 PMC4972037__F1 Understanding Extranuclear (Nongenomic) Androgen Signaling: What a frog oocyte can tell us about human biology 367 6714 27043 4342 1956 PMC4980330__F2 Regulation of the Hippo pathway by multiple upstream signals 4018 3156 6010 9113 26524 154810 PMC5006314__F7 Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFBeta-p38MAPK pathway 5159 4681 595 1019 PMC5225216__F1 Intracellular energy relocation in fat body cell of Drosophila and immune cell of human 4615 114609 3661 PMC5250589__F1 Impact of ELS on the normal development of tissues and organs 627 4803 2638 1401 PMC5292191__F1 TGFB signaling pathways 387 5879 2695 126669 2885 6714 6010 6678 PMC5341926__F3 Proteomic analysis uncovers common effects of IFNG and IL-27 on the HLA class I antigen presentation machinery in human cancer cells 4940 6672 51371 3725 324 4552 51166 545 2593 1719 7298 PMC5362544__F1 The association between copper transporters and the prognosis of cancer patients undergoing chemotherapy: a meta-analysis of literatures and datasets 475 540 538 PMC5385394__F1 Major pathways associated with pancreatic ductal adenocarcinoma and site of action of current treatments 1956 2475 4089 PMC5442177__F2 Transcriptional regulation of hepatic mIndy mRNA levels in model organisms and humans 196 405 6774 875 PMC5545725__F4 Proposed model of dopamine dysregulation in the nigrostriatal pathway in schizophrenia 7054 1813 1312 4128 PMC5666340__F4 CyaA toxin of B.pertussis inhibits the TRIF-dependent signaling pathways in human monocyte derived dendritic cells (MDDC) 7099 7097 4615 114609 7189 3661 6772 PMC5739098__F8 Proposed model of changes in epigenetic status before and after establishing hiONs from hiPSCs and epigenetic silencing by hyperglycemia in orexin neurons 23411 8473 10724 10020 2638 PMC5790950__F1 KSHV entry by macropinocytosis and trafficking in the human microvascular dermal endothelial cells 51510 7251 79643 387 6714 PMC5842063__F1 METABOLIC SWITCHING AND CELL FATE DECISIONS: IMPLICATIONS FOR PLURIPOTENCY, REPROGRAMMING AND DEVELOPMENT 3976 23411 4609 9314 3091 9242 PMC5927620__F4 Metabolic pathways dysregulated in the context of disease 4118 11113 282969 PMC5953777__F2 Connectivity of differentially expressed genes in the important cancer signaling pathways in the exposed children are shown according to gene expression levels (with ≥ 1.5-fold change, t test, p < 0.05) 1356 7157 4609 6651 4791 PMC6033660__F2 Schematics of classical CSR from IgM to IgA 3492 759 761 613 PMC6099685__F7 The potential pathway underlying the anticancer activity of CK in human HCC cells 6774 22926 83939 PMC6237563__F6 Schematic representation of the downstream targets of the MVA pathway, depicting its various intermediates (blue), end products (green) and functional implications (yellow) 3652 387 2695 6722 PMC6274736__F1 Schematic diagram of c-mesenchymal–epithelial transition (c-MET) activation signaling pathways 3082 1956 238 2885 6774 PMC6341466__F1 Expanding the Clinical and Molecular Characteristics of PIGT-CDG, a Disorder of Glycosylphosphatidylinositol Anchors 55650 23556 9488 93183 5281 54965 84720 284098 54872 9487 8733 10026 51604 8818 94005 5277 128869 5283 5279 9091 51227 80055 84992 27315 93210 95 PMC6365104__F1 Main regulation modes of copper transporters in human cells 7792 6667 475 PMC6434111__F1 l-Arginine de novo synthesis pathways 5009 367 11113 102724895 PMC6442574__F1 Focal forebrain IR/IGF1R DKO eliminates signaling by receptor homodimers and hybrids in hippocampus or central amygdala 3481 3479 3480 3667 2885 2932 2475 PMC6539494__F4 Single-Cell RNA-Sequencing Identifies Activation of TP53 and STAT1 Pathways in Human T Lymphocyte Subpopulations in Response to Ex Vivo Radiation Exposure 51199 150696 4609 PMC6639256__F7 READ pathways (p53 signaling pathway, intestinal immune network for IgA production, and colorectal cancer pathway) enriched in DEmRNAs during READ 472 100187761 324 572 207115 PMC6667928__F3 Therapeutic strategies are involved in heme metabolic pathway 3240 9429 9332 PMC6689970__F1 Schematic overview of NAD biosynthesis pathways 203447 93100 10135 4837 PMC6784137__F4 Interactions between autophagy and immunity in response to viral infection 4615 8178 920 PMC6836709__F9 Pathways to autoimmunity and autoinflammation in ABIN1[D485N] mice 51284 4615 51135 3654 7083 203 PMC6859461__F3 Cancer pathway analysis of DEPs 3081 4117 2241 8567 5066 572 170 PMC6892284__F1 Number of studies suggest that an increase in microbial BSH activity results in a reduction in stimulation of intestinal FXR 1581 9965 64241 64240 PMC6905468__F8 Schematic summarizing the effect of ATR kinase inhibition in cisplatin-treated quiescent cells 5111 84126 545 PMC6913967__F3 Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation 3932 868 27040 5728 2353 355 PMC6962451__F5 The proteome landscape generated by the direct comparison between cells differentiating in alginate capsules and Matrigel differentiated-cells 2475 6010 4553 5728 472 672 5465 6256 PMC7040165__F1 Extrinsic signaling pathways governing stemness of pluripotent stem cells 3976 4838 2580 6651 79923 PMC7047153__F1 Innate immunity and antiretroviral activities 920 4615 3665 PMC7060963__F5 Transcriptomics and pathway analysis of CRISPLD1-KO-hiPSC-CM 3897 7124 7157 6010 9118 6262 PMC7180296__F6 MetaCore‐based analysis of two major KEGG pathways and their regulatory gene interactions in skeletal and cardiac human fetal mesoangioblasts (MABs) 4656 545 1356 64400 759 PMC7254680__F1 Scheme for the overall GPI-APs biosynthetic pathway, structural remodeling and transport 95 93210 27315 80055 58986 10026 8733 5279 5283 84720 8818 9487 5281 284098 93183 54872 PMC7269991__F1 SOCS family genes were re-analyzed by KEGG pathway enrichment 4170 8027 5292 10379 2670 2475 PMC7281607__F1 Simpified major metabolic pathways of tryptophan (TRP) in humans 8564 8942 130013 PMC7518314__F1 Overlap between immune-signaling genes that are associated with pollution and SCZ 3661 7099 1401 929 PMC7765985__F2 Networks generated from genes altered in intestinal- and diffuse-type gastric cancer (GC) 5053 100187761 5898 PMC7833367__F2 Biphasic role of wnt/Beta-catenin pathway in heart muscle development 55897 22943 1499 406905 PMC7848376__F6 A, On the left, the Neurotrophin signaling pathway (modified from KEGG hsa04722), showing genes targeted by miRNAs (n = 15) involved in its modulation 581 8767 572 PMC7954751__F9 Hormonal regulation of human DNA methyl transferases 5741 2152 2638 6714 1786 1788 1789 PMC8138183__F2 Human Cytomegalovirus Host Interactions: EGFR and Host Cell Signaling Is a Point of Convergence Between Viral Infection and Functional Changes in Infected Cells 6772 1956 6667 PMC8276045__F2 T Cell Specificity: A Great Challenge in Chagas Disease 3105 324 958 920 7054 914 PMC8290102__F1 Streptococcus pneumoniae, S. pyogenes and S. agalactiae membrane phospholipid remodelling in response to human serum 6693 283871 716 5091 PMC8371910__F2 Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease 29851 1493 942 941 90865 3458 PMC8456902__F2 Estrogens in polycystic liver disease: A target for future therapies? 6714 847 1956 2852 10424 10857 PMC8474995__F1 Is there a place for cellular therapy in depression? 1401 2638 114548 PMC8567041__F4 Integrative multi‐omics approach for mechanism of humidifier disinfectant‐associated lung injury 4313 4087 4088 5176 PMC8647113__F9 Study of Baicalin toward COVID-19 Treatment: In silico Target Analysis and in vitro Inhibitory Effects on SARS-CoV-2 Proteases 1311 1636 126669 7054 50853 7429 100653365 1314 6955 4117 PMC8783345__F6 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease 7054 5447 4118 PMC8783345__F4 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease 100187761 8168 5970 367 PMC8783345__F5 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease 7054 8205 4099 6651 100187761 5624 4118 PMC8795088__F5 Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease 1152 627 3064 PMC8863805__F1 An enhanced triple fluorescence flow-cytometry-based assay shows differential activation of the Notch signaling pathway by human papillomavirus E6 proteins 9794 3280 102 PMC8892079__F1 Structural basis for dysregulation of aminolevulinic acid synthase in human disease 7389 5498 1371 7390 2235 210 PMC9145792__F9 Artonin F Induces the Ubiquitin-Proteasomal Degradation of c-Met and Decreases Akt-mTOR Signaling 2475 581 3082 9101 PMC9157603__F6 Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology 5972 389333 7054 PMC9243258__F4 R-loop Mediated DNA Damage and Impaired DNA Repair in Spinal Muscular Atrophy 6741 545 672 472 3014 23064 PMC9438316__F1 Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma 2597 47 967 355 2744 PMC9454636__F2 Drosophila as a Model for Human Viral Neuroinfections 27161 3661 3665 PMC9468923__F5 Key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor 196 3603 2475 PMC9582503__F1 MicroRNA and Their Potential Role in Conjunctival Disorders 54487 29102 5901 PMC9590394__F1 T cell dysregulation in inflammatory diseases in ICU 920 842 1493 3902 3575 PMC1819569__F6 The signalling pathways involved in Pam3Cys-induced degranulation and cytokine/chemokine production in human LAD 2, MLMC and BMMC 5066 7096 7097 6347 PMC2430503__F1 Resistance to ErbB-targeted cancer therapeutics 3486 3667 2475 PMC2593023__F1 Unexpected pieces to the senescence puzzle 673 10682 3490 3579 PMC2964177__F1 ErbB2 cellular signaling pathways and lapatinib mechanism of action 2064 5728 2475 PMC2981516__F6 Demosponge EST Sequencing Reveals a Complex Genetic Toolkit of the Simplest Metazoans 8178 100187761 6761 PMC3007169__F1 Arsenic: a potentially useful poison for Hedgehog-driven cancers 6608 2736 2735 PMC3030666__F2 Impact of Aging on Dendritic Cell Functions in humans 4615 5728 3661 3569 PMC3103989__F1 Endocrine, paracrine and autocrine regulation of the IGF-1R pathway and therapeutic strategies for its disruption 3480 2691 126669 3482 5728 2475 PMC3432651__F2 Involvement of the target of rapamycin (mTOR) pathway in human disease syndromes 5728 4763 4771 6009 7428 PMC3618530__F8 Interleukin-1B enhances cell migration through AP-1 and NFKB pathway dependent FGF2 expression in human corneal endothelial cells 3553 3554 7189 PMC3919979__F9 CNP action in the SRG 2638 1267 1080 PMC3927127__F2 Cytokine-induced differentiation of human B cells in vitro: requirement for IL-21 signaling in vivo 613 50615 3718 6774 3586 958 940 941 PMC4066870__F4 Smoke mediates EGFR/Src-dependent and independent cell migration 1956 6714 3984 PMC4180336__F5 Bile acid feedback inhibition of bile acid synthesis 9965 3172 1582 2264 PMC4445694__F1 Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists’ arsenal 6774 367 6667 PMC4509079__F1 BMI-1 is important in the regulation of cancer and CSCs, functioning through the activation of multiple signaling pathways 57167 4609 648 PMC4529925__F3 Model of SAM68 interaction with pre-mRNAs and splicing regulation 6714 960 6426 598 2475 PMC4581244__F1 Alterations of the KP in EAE and MS 4397 3458 8564 PMC4676710__F1 A and B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) autoimmune response in WHI human prediagnostic TNBC samples, based on Ingenuity Pathway Analysis 1499 2353 5447 PMC5408584__F5 Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias 355 6256 5465 2166 27163 PMC5778108__F1 Canonical and non-canonical NFKB signaling in humans 4050 613 4055 958 5970 5971 PMC5825917__F3 Means to enhance the immune response in the tumor microenvironment (TME) 2191 3082 3458 PMC6170780__F4 Prediction of antiviral targets [reactions] from single-reaction perturbations in a virus-optimized system for CHIKV, DENV and ZIKV 4397 4975 7808 PMC6371002__F2 Mechanistic cross-connection between the transforming growth factor beta pathway and bone morphogenetic protein signaling 3077 7036 659 57817 PMC6977568__F1 HER2 signaling pathways in cancer cell and cardiac myocyte 3084 7155 8864 PMC7000593__F6 Role and pathway acquired by keratin, cytokines, and interleukins in horn SCC 6772 3569 7189 PMC7069221__F1 Estrogen biosynthesis and signaling pathways 1588 1543 1545 PMC7347012__F6 Development of ocular surface ectodermal cell lineages from human induced pluripotent stem cells 652 6423 22943 5080 PMC7494756__F1 Output and input pathways of the central circadian timing system in the mammalian brain that may be involved sundowning–related behavioral aggression and circadian dysfunction in Alzheimer’s disease and related dementias 3535 4852 551 7432 PMC7499322__F3 Inhibitory roles of MSC-derived exosomes in tumors 9242 5347 100302158 PMC7689008__F1 Cell adhesion molecules (CAMs) regulate protein synthesis machinery 2534 6714 5728 1977 2475 7018 PMC7707088__F1 Function and therapeutic potential of G protein‐coupled receptors in epididymis 10149 1080 2078 55366 PMC8150686__F1 Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research 2534 2885 4286 PMC8245300__F5 ATRX-dependent mechanisms in physiology, cancer and human genetic disease 546 1616 9555 5978 PMC8255612__F1 BMP Signaling in Endothelial Heterogeneity 4091 659 4089 PMC8260517__F2 Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities 2475 9113 26524 PMC8268006__F1 Beyond RAS and BRAF: HER2, a New Actionable Oncotarget in Advanced Colorectal Cancer 5290 2475 673 1956 6774 PMC8350018__F3 Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway 2520 1499 4790 367 140805 3479 828 PMC8495394__F1 P38G in Cancer: From review to outlook 898 5978 619501 PMC8581311__F7 Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment 1956 1977 2065 3667 PMC8783345__F7 Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell‐type specific manner that are altered in inflammatory bowel disease 1356 4118 5891 PMC8788185__F3 Molecular mechanism of therapeutic approaches for human gastric cancer stem cells 6608 6774 79923 1499 PMC8847669__F1 Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization 970 3576 958 7186 PMC8891017__F7 Genetic associations of protein-coding variants in human disease 324 7018 2153 PMC8911130__F1 An Assessment of Selected Molecular and Biochemical Markers of the Folate Pathway as Potential Risk Factors for Fetal Trisomy 21 during the First Trimester of Pregnancy in the Polish Population 2618 7298 4524 4548 4552 875 PMC8926145__F3 Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function 7189 23118 78990 PMC9059347__F1 Constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection 38 3949 22937 PMC9098828__F1 Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism 3156 22937 255738 3949 PMC9164338__F7 Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses 3661 356 355 6772 7297 PMC9202199__F9 Power of heteronemin in cancers 5728 572 2475 6774 595 PMC2777122__F2 Step 2: T-cell activation and costimulation 324 325 4280 PMC3137772__F2 De novo biosynthesis of dolichol phosphate in human 3652 79947 79644 PMC3547105__F1 The autotaxin-LPA-LPA1pathway 4018 2520 5091 PMC5441174__F7 Schematic diagram of the FOXM1/Beta-Catenin complex in human osteosarcoma cells 2305 1499 595 6925 PMC5797575__F8 Proposed scheme of the possible mechanisms associated with the effects of asiaticoside (AS) on attenuation of cell growth inhibition and apoptosis induced by AB1-42 in human brain microvascular endothelial cells (hBMECs) 7189 7099 4615 PMC6362621__F1 VEGFA-VEGFR2 signaling pathways and their pharmacological inhibition occur across the glomerular filtration barrier 7422 100187907 673 2475 PMC7787056__F4 Duality of human oncoproteins: drivers of cancer and congenital disorders 3815 5979 238 1956 PMC8012701__F2 Lipid metabolisms change in dormant cancer cells 3156 6307 3930 7108 6721 29116 6319 6296 55902 PMC8319020__F1 Sialic acid O-acetylation: From biosynthesis to roles in health and disease 54414 10559 55907 64921 PMC8539121__F1 In Vitro Analysis of Deoxynivalenol Influence on Steroidogenesis in Prostate 6770 1583 1586 3293 PMC4032345__F3 Comparative Proteomic Analyses Provide New Insights into Low Phosphorus Stress Responses in Maize Leaves 5183 2597 2695 6648 PMC9502527__F2 Molecular Pathways of WRKY Genes in Regulating Plant Salinity Tolerance 847 50964 4609 PMC9002269__F1 Fine-Tuning Cold Stress Response Through Regulated Cellular Abundance and Mechanistic Actions of Transcription Factors 23261 23125 4602 PMC8480016__F8 Identification of miRNAs-mediated seed and stone-hardening regulatory networks and their signal pathway of GA-induced seedless berries in grapevine (V. vinifera L.) 407020 100616250 95 378 9049 54994 407043 80320 7018 5426 PMC4584981__F3 Model representing cross talk between drought and pathogen stress signaling pathway from individual stress studies and its relation to shared and unique response pathway provoked under combined stress 4602 2077 4609 PMC5853495__F7 Model for biosynthesis of sterols and other isoprenoids in rice roots 3652 1611 4018 PMC6277783__F2 Schematic representation of various processes during seed filling stage in both monocot (top left) as well as dicot (top right) plants 6476 3240 101448070 201989 2875 5183 PMC9455954__F9 Comparative Physiological and Transcriptomic Analyses of Two Contrasting Pepper Genotypes under Salt Stress Reveal Complex Salt Tolerance Mechanisms in Seedlings 100653366 100187761 2077 5624 11316 PMC7080263__F5 RNA-seq transcriptomic analysis reveals genes mediating salt tolerance through rapid triggering of ion transporters in a mutant barley 6655 2077 27010 PMC8906750__F1 Monolignol pathway metabolite levels in the C. hassleriana seed coat 1312 790 1611 PMC9103730__F1 Abiotic Stresses in Plants and Their Markers: A Practice View of Plant Stress Responses and Programmed Cell Death Mechanisms 914 2077 847 PMC9554999__F3 Comparison of meiotic transcriptomes of three maize inbreds with different origins reveals differences in cell cycle and recombination 7095 11231 1998 468 2733 7466 22926 4508 4397 581 100506742 100187907 258010 6400 PMC9603070__F10 Melatonin Enhances Drought Tolerance in Rice Seedlings by Modulating Antioxidant Systems, Osmoregulation, and Corresponding Gene Expression 4015 847 438 PMC5330121__F6 The interactive pathways of stress-responsive miRNAs and their targets 4602 80763 4800 PMC7557389__F9 Proposed pathway showing the effects of nanopriming with MWCNT–COOH on the membrane lipid metabolism of peatland boreal forest species in response to possible alleviation of seed dormancy and improved vigor 4018 5091 780904 5662 84249 283871 PMC8999833__F3 Candidate Genes and Pathways in Rice Co-Responding to Drought and Salt Identified by gcHap Network 4881 9001 8213 133 PMC9118424__F6 Transcriptome and Metabolome Analysis of the Synthesis Pathways of Allelochemicals in Eupatorium adenophorum 10763 2224 4597 1121 PMC9494650__F6 Proteomic and Metabolomic Revealed Differences in the Distribution and Synthesis Mechanism of Aroma Precursors in Yunyan 87 Tobacco Leaf, Stem, and Root at the Seedling Stage 2821 47 3417 175 100 PMC2832236__F5 BS and M chloroplast distribution of proteins involved in primary carbon metabolism 5183 283871 718 2695 6120 5236 55276 5230 5232 PMC3267732__F4 Deeply Branching Thermophilic Bacterium with an Ancient Acetyl-CoA Pathway Dominates a Subsurface Ecosystem 6120 7086 5447 PMC3442575__F4 Genes Involved in the Calvin Cycle and Photorespiration.(A) Schematic of the Calvin cycle and photorespiration pathway in C 6472 252842 1431 2653 5230 6887 6470 PMC3509894__F3 Vitamin B12 Synthesis and Salvage Pathways Were Acquired by Horizontal Gene Transfer to the Thermotogales 867 367 351 873 PMC3928158__F1 Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells 4179 972 999 4609 3611 64127 PMC4141456__F1 Anti-microbial responses 4615 8772 5966 PMC4309433__F1 Metabolic network of tomato cells 7083 7084 2597 11113 355 5183 1431 4118 6341 PMC4323418__F7 Map of central carbon metabolism highlighting CceR and AkgR targets 1896 11113 4118 PMC4531352__F3 Maize Primary Metabolic Network Involving Key Genes and Metabolites Identified in This Study.Metabolites that were not identified in this study are shown in purple 5164 1431 667 3712 183 7054 PMC4936558__F6 Genes up- and downstream of flavonol biosynthesis are also affected in the Δy mutants 4602 4156 7880 2184 2954 1312 729230 1232 PMC5017163__F1 Different strategies of metabolic regulation in cyanobacteria: from transcriptional to biochemical control 183 25801 3250 5226 7086 2819 2821 PMC5555159__F24 Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products 9487 5277 54872 5283 93183 5281 23556 5279 9053 PMC6018831__F3 Metabolic reconstruction of LSUCC0530 100187907 4118 572 11113 1491 PMC6961632__F1 Unique Features of Nodules.(A) Nod factor activation of the CSSP 7018 10595 51199 4335 5183 1638 6750 2237 PMC7694542__F3 Conservation of signalling pathway proteins in Myxococcaceae 79800 60 10682 PMC8107475__F1 Abscisic Acid as an Emerging Modulator of the Responses of Plants to Low Oxygen Conditions 54861 2077 11101 PMC8211227__F3 Schemetic drawing of carbon fixation in photosynthetic process (adapted from KEGG pathway zma00710) 5164 5106 10873 4200 PMC8398409__F6 Reactive Oxygen Species in Host Plant Are Required for an Early Defense Response against Attack of Stagonospora nodorum Berk. Necrotrophic Effectors SnTox 27324 847 57716 PMC8571860__F6 Wheat transcriptome profiling reveals abscisic and gibberellic acid treatments regulate early-stage phytohormone defense signaling, cell wall fortification, and metabolic switches following Fusarium graminearum-challenge 3156 108348016 578 51411 PMC8704836__F6 Lowering pO2 Interacts with Photoperiod to Alter Physiological Performance of the Coastal Diatom Thalassiosira pseudonana 5183 847 4519 6390 4513 1352 PMC9112071__F6 Chromosome-Level Genome of the Camphor Tree and the Underlying Genetic and Climatic Factors for Its Top-Geoherbalism 3652 4597 4598 PMC9205118__F8 Identification of the key flavonoid and lipid synthesis proteins in the pulp of two sea buckthorn cultivars at different developmental stages 27343 11201 4018 5091 8694 PMC9936654__F10 Transcriptome analysis of Populus × canadensis ‘Zhongliao1’ in response to low temperature stress 9978 7508 1069 1022 902 7507 2067 5111 3978 PMC10031116__F5 Extracellular matrix stiffness—The central cue for skin fibrosis 7049 7939 7048 7046 80176 2885 2475 6714 9618 6010 55742 3611 85451 9113 26524 PMC10041518__F2 Nucleotides fuel cancer cell growth and proliferation 4609 3091 1719 8473 978 1723 718 4199 PMC10041518__F5 Hyperactive nucleotide synthesis confers resistance to a range of therapeutic interventions 1633 2879 8205 1723 790 3091 7372 PMC101242__F7 Up-regulation of RAD51 in 8-MOP-treated cells 10111 5888 5893 PMC1083933__F2 Cell cycle trials in Salamanca 4342 891 983 4661 699 PMC1087583__F5 The secretory pathway and UPR under different conditions 27072 11231 7317 PMC1087795__F1 Schematic depiction of the S 2819 2820 84249 5091 PMC1088370__F1 Topologies of the three networks 999 991 324 4151 PMC1168613__F1 Comparison of the D 4615 8772 5966 PMC1176393__F2 Regulatory network of stress responses to drought, salt, and cold: specificity and cross-talk 867 6655 6654 PMC1197416__F6 Several signaling pathways converge to drive actin polarization 998 6492 6493 PMC120784__F11 Upper part of the glycolytic pathway and pathways for production of glycerol, trehalose, and glycogen, with all proteins and their isoforms indicated 6675 5236 101448070 6886 7167 PMC123677__F3 The action of S-phase checkpoints in the suppression of spontaneous genome instability 92749 5984 5985 5983 5982 5111 1644 4361 PMC1297640__F1 Systems and molecular complexity in glycobiology 55577 2582 10020 2645 2673 8790 2821 29926 4351 2592 130589 51083 339855 947 PMC1315902__F2 Multiple roles for kinases in DNA replication 717 2237 5111 PMC1361319__F1 Scheme of branch pathways of phenylpropanoid metabolism in plants leading to the synthesis of anthocyanins, flavonols, PAs, and lignin 1312 790 718 PMC137069__F1 Hh-signaling pathway 3092 2619 6608 51684 51715 PMC1383550__F2 Two branches of the class I PI3K pathway 5728 5163 998 2932 7018 PMC1386711__F4 MAPK signaling pathway mapping 4976 998 6402 2521 84188 PMC1410804__F7 Cdc42 regulates HF differentiation and cell–cell contacts in keratinocytes by modulating the turnover of Beta-catenin and plakoglobin 1499 998 999 324 PMC1431703__F5 Comparison of results with the known response pathway 57461 84188 5354 5355 79577 998 65005 124995 54948 10573 PMC1551980__F3 Ubiquitin Signaling in the NFKB Pathway 1540 4615 23118 7189 PMC1551980__F4 Ubiquitin Signaling in the NFKB Pathway 8915 10892 4615 8717 7186 7189 64127 PMC155330__F7 slpr, encoding Drosophila MLK, is the MKKK for the Jun kinase pathway during dorsal closure in the fly 998 2645 4478 1386 PMC156764__F1 NEW EMBO MEMBER’S REVIEW 7124 8717 4615 7189 5970 595 8772 PMC1574111__F3 Proposed mechanism for FK506-potentiated neurite outgrowth 4803 2885 998 PMC1618798__F2 Intrinsic apoptotic signaling pathway 637 581 5624 PMC1664665__F3 ECM-integrin signalling coordinates with growth factor signalling to regulate efficient axon growth 3611 998 387 PMC1667087__F9 F igure 9.— 1956 23013 4734 PMC1681476__F1 An SBGN process diagram (A) and a molecular interaction map (B) of a signaling pathway triggered by ligand binding to EGFR molecules 1950 1956 126669 2885 5163 PMC17314__F1 An integrated view of the biology of Halobacterium NRC-1 6717 847 6729 6728 914 PMC1774725__F1 Tumour necrosis factor related apoptosis inducing ligand (TRAIL) receptor signalling 8772 8717 7186 PMC1779900__F6 Some signaling pathways that could mediate long-term changes in cellular plasticity as a function of sexual experience 126669 2885 23237 1020 2353 PMC1820632__F1 Cytokine-Effects on Glucocorticoid Receptor Function: Relevance to Glucocorticoid Resistance and the Pathophysiology and Treatment of Major Depression 7297 3716 6772 6774 PMC1828071__F2 Insulin-mediated activation of PI3K signaling pathways 5163 5164 572 2931 7249 7248 5140 6009 2475 253260 1975 1977 PMC1847591__F1 Drugs that regulate hepatic bile acid and other organic solute uptake, synthesis, detoxification and secretion 1581 1576 6822 PMC1856765__F7 Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications 581 8772 1431 1386 3569 7124 PMC1857267__F2 Altered macrophage differentiation and immune dysfunction in tumor development 3718 1051 383 4843 PMC1866211__F1 Hedgehog signalling pathway 5972 8454 8405 8452 PMC1894978__F5 The secretory pathway under different ER stress conditions (t-PA secretion, tunicamycin and DTT) together with examples of genes that are transcriptionally induced or repressed 85365 8818 10195 55329 23559 91869 6402 27159 2619 8615 11161 11231 6731 PMC1934514__F2 Mechanisms of Action of GLP-1 in the Pancreas 1950 5266 759 2308 2475 PMC1939900__F6 Different signaling pathway mediated by A3(IV)NC1 2475 1977 5970 PMC1952166__F1 Signaling cascades required for TCR-mediated integrin activation 27040 3702 5335 998 4485 PMC1952230__F1 Regulation of CXCR4 Signaling 6714 6010 5163 998 PMC1963413__F1 Oval of iNOS-inducing signaling pathways 29949 7098 1386 8775 PMC1964795__F5 INHIBITION OF MAPK AND STIMULATION OF AKT KINASE SIGNALING PATHWAYS: TWO APPROACHES WITH THERAPEUTIC POTENTIAL IN THE TREATMENT OF NEURODEGENERATIVE DISEASE 7249 7248 6009 4193 581 572 PMC1992519__F2 Signaling on the endocytic pathway 1956 8411 4087 4088 1950 PMC1993906__F16 Adenylyl cyclases are targets of multiple regulatory signaling pathways and respond differently, depending on which group they belong to 6714 998 6010 5331 5332 5330 23236 PMC2042021__F6 Contrasting Infection Strategies in Generalist and Specialist Wasp Parasitoids of Drosophila melanogaster 1644 8027 4615 7275 7186 7011 PMC2043390__F9 Biphasic expression and up-regulation of HWP1 at the bud-hypha transition 10487 998 3084 PMC20438__F5 Schematic diagram of possible Rad6-mediated metabolic pathways 56852 5111 51455 PMC2134838__F2 ALTERNATE ROUTES FOR DRUG DELIVERY TO THE CELL INTERIOR 9341 8674 143187 10652 847 5870 2821 PMC2172491__F1 The PI3K–Akt–TSC–TOR pathway and feedback regulation of insulin/IGF-I signaling 3630 572 1977 PMC2172900__F9 A model of how the Tor1/2 and Lst8 proteins affect amino acid biosynthesis and Gap1p sorting 54903 3417 3418 PMC2206598__F4 Regulatory networks sensitive to tyrosine kinase inhibitors in H3255 and MKN45 cells revealed by PhosphpScan-SILAC study 1956 1969 100506658 3728 203 5901 5972 PMC2233890__F4 Multiple ERK scaffold regulate growth factor and adhesion signaling 998 8682 2002 375 377 382 381 PMC2246264__F9 Proposed mechanism for MnSOD-mediated mitochondria to nucleus signaling and crosstalk with the IIS pathway 5728 6009 207 11221 5966 4791 PMC2248159__F2 A part of the yeast cell cycle pathway available from KEGG [26] 84188 2765 1123 1201 991 990 PMC2253531__F5 Induction of immune response to Wolbachia infection in S2 cells 4615 7275 8772 5966 PMC2268064__F2 Signalling pathways leading to the phosphorylation and inhibition of glycogen synthase kinase 3 (GSK3) 1950 5163 2885 2475 PMC2278091__F1 F igure 1.— 6770 1956 6714 2885 7428 6010 1499 4089 23237 999 PMC2292467__F6 DNA replication and damage checkpoint regulation 5111 4360 8318 4549 6052 PMC2311275__F4 Following biological functions (central carbon pathway, redox and respiration coordination, phosphate starvation, nitrogen gestion, carbohydrates, nucleotide and amino acids metabolism, ribosome activity) 5091 100187761 1314 3492 4118 11113 831 84890 100188011 57817 100187907 PMC2329845__F2 IPA of the genes encompassed by the conserved 166 signatures and belonging to the Wnt signal transduction pathway 11197 5300 1499 142 3065 8313 960 6925 3725 6662 PMC2330263__F2 Integration of Progesterone Receptor Action with Rapid Signaling Events in Breast Cancer Models 6714 2885 595 PMC2358953__F2 Network diagram showing the checkpoint response to uncapped telomeres 5884 5810 5883 PMC2390552__F8 Analysis of Wnt signaling processes in ERK1MO and ERK2MO gene expression profiles 1046 51701 2624 80320 4942 5881 324 1499 64321 6946 145258 PMC2396785__F2 Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle 6714 6010 998 PMC2405801__F2 Description of possible involved signalling pathways 1956 1950 2885 998 5879 1386 2002 PMC2405914__F4 Catenins: Keeping Cells from Getting Their Signals Crossed 6469 1499 998 6010 PMC2413058__F7 Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor 1956 867 3423 PMC2430594__F1 Cartoon of two of the most promising DNA repair pathways for cancer therapeutics 183 4350 5111 7515 545 472 PMC2435603__F8 Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways 4803 2885 998 5163 PMC24579__F6 Integration of tyrosine kinase signaling to both cAMP and MAPK 1,2 pathways, resulting in cell cycle arrest and the reduction of MAPK 1,2 triggered proliferation 595 6300 5594 PMC2474943__F4 Points of action of flavonoids within JNK pathway 4089 1386 3297 PMC2528859__F2 The UPR sensors PERK, IRE1A, and ATF6 control mRNA translation and transcriptional induction of UPR-regulated genes 3375 22926 83939 468 PMC2531163__F3 Developmental signaling pathways 6608 51684 324 1499 4609 PMC2533145__F10 Rap1 and glycolytic/TCA cycle reaction 7167 2023 2026 127 130 PMC2546909__F1 Signal transduction pathway elicited by Env interaction with CCR5 required for Rac-1 activation and membrane fusion 1234 7038 7074 PMC25571__F9 A model of cnxPg action 324 10940 6929 PMC2559911__F7 Model for the function of SHC-1 in IIS and JNK signaling 3630 6464 5163 PMC2567351__F1 T Cell Receiptor Signaling Pathway 3932 27040 2885 4863 1019 940 PMC2571037__F1 Anticancer therapy: boosting the bang of Bim 5728 5163 572 2475 331 PMC2581573__F1 The IL-1 signaling pathway 51135 4615 7189 23118 PMC2583357__F1 ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY 7249 5728 3611 6714 7248 6009 2475 572 10743 1977 3725 2353 PMC2587303__F1 mTOR inhibition as a Therapeutic Strategy in the Management of Urologic Malignancies 3667 7249 7248 4088 2475 253260 4087 6009 6010 5163 PMC2590699__F1 Current model for Okazaki fragment maturation 1763 2237 80119 PMC2592633__F1 RNAi pathways in Drosophila 192669 29102 84944 27161 26523 PMC2597498__F2 TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway 253260 2475 6009 7249 1977 PMC2600469__F4 Genes regulated by SHP in PPAR signaling pathway 948 6319 1356 4023 PMC2610675__F6 Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells 2885 407 2534 1956 PMC2614485__F6 A simplified Hh signaling pathway, constructed from combined Drosophila and mammalian data 6608 100188011 2619 6497 PMC2626169__F1 A simplified view of the sex-determination pathway in XX animals (A) and XO animals (B) 6382 9672 8453 6383 27429 PMC2632675__F3 Cell cycle pathways in S 4155 3024 100134934 1610 PMC2633067__F2a Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells 3630 2147 55619 324 6010 10152 5829 7414 759 PMC2635127__F3 Small GTPase non-Smad pathway 4088 998 4089 387 PMC2639036__F1 Single-strand break repair pathways 6741 4968 5447 11284 5111 5423 2237 3980 PMC2640984__F3 Distribution between short and long flap removal pathways 1763 80119 2237 PMC2644070__F2 Homologies between mammalian and insect immune defense pathways 51135 7189 23118 8717 7186 7185 8772 PMC2645306__F2 Migration of Airway Smooth Muscle Cells 6714 387 998 PMC2646278__F5 Pathways of global genome nuclear excision repair (GG-NER) and transcription-coupled nuclear excision repair (TC-NER) 7508 9978 1069 1022 7507 902 PMC2647163__F3 Advances on the Understanding of the Origins of Synaptic Pathology in AD 3643 5879 2534 23237 2932 1020 627 PMC2652310__F1 Anaerobic metabolic pathways in C 4190 4191 5132 PMC2655360__F7 Pathway maps generated using GenMapp depicting increased glycolytic protein expression in differentiated intestinal epithelial cells relative to crypt cells 2645 2821 2191 5213 51199 226 229 2597 26330 5224 2806 5618 3945 5091 5160 5053 1737 5162 1738 PMC2657775__F6 Enrichment of Wnt signaling pathway 51701 5624 4089 324 9350 404685 9475 387 PMC2659375__F2 MET as a target for treatment of chest tumours 5829 2885 6714 2549 998 6010 PMC2664745__F1 Molecular and cellular biology of enhanced cognition 627 1020 57576 PMC2665046__F3 Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin-Dependent N-End Rule Pathway 123803 11101 4553 PMC2666541__F1 (panel A) ODC expression is regulated by a number of signaling pathways 4609 324 6303 4513 4512 PMC2667944__F1 Angiotensin converting enzyme 2 in the brain 183 59272 1636 PMC2668926__F1 EGFR Signaling Pathway 2885 595 1019 100187761 1021 PMC2668954__F4 Mechanotransduction gone awry 6010 2626 1958 PMC2670612__F2 Tumor resistance to EGFR-targeted therapies 10928 1956 2885 5900 5728 2821 PMC2673958__F1 Role of Adenomatous Polyposis Coli (APC) and Microtubules in Directional Cell Migration and Neuronal Polarization 6010 998 324 PMC2674123__F10 Signaling cascade of PI3K/AKT pathway 2885 3611 5728 2549 9846 5163 11140 572 6009 2475 1977 PMC2674743__F2 Altered insulin signaling by lipid intermediates 2475 10554 355 PMC2676446__F1 Regulation of p53 and MDM2 and the outcomes of p53 activation 4193 355 581 545 472 7508 PMC2678244__F1 Abl Tyrosine Kinases in T-cell signaling 324 3932 3702 7409 1794 5879 5335 7535 PMC2682028__F9 Changes in metabolism in Prx1-Cre; PORlox/lox limb bud cells and levels of cholesterol 39 47 4597 2224 4015 PMC2690004__F3 Metabolic reconstruction of H 5805 324 2242 PMC2692221__F1 BER subpathways for damaged bases and DNA strand breaks 4350 2922 5423 7515 5111 4968 PMC2694487__F5 Human presenilin 1 and 2 (PSEN1 and PSEN2) subnetworks 55851 5664 3955 6622 2861 1636 10652 PMC2694616__F1 Genomic Strategy to Elucidate Modules of Oncogenic Pathway Signaling Networks 472 2475 4193 3725 PMC2696318__F3 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE 5728 5163 2885 673 4193 572 2309 2475 PMC2696318__F7 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE 5728 2885 6714 2475 572 PMC2696553__F1 Store-operated Ca2+ entry in T cells 84876 3932 27040 50943 PMC2698574__F9 The VACV- and CPXV-stimulated PI3K/Akt pathway of biological relevance in spontaneously immortalized A31 and MEF cells 5163 572 1977 PMC2713381__F8 MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway 2885 5163 5164 5894 PMC2719108__F2 Schematic representation of the renin angiotensin system 59272 5972 367 1636 1611 545 PMC2720031__F1 GR signal transduction pathway 7175 3479 6376 PMC2722250__F2 Silent chromatin assembly in budding and fission yeast 23237 63928 11261 PMC2723150__F1 Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is central for physiological responses to extracellular and intracellular signals 140838 4826 7939 23440 3630 50632 4535 7956 100187761 367 5901 4118 PMC2724975__F6 Illustrating expansion results with ambiguity networks 220134 6402 4199 PMC2726710__F2 Intracellular signaling consequences of calpain-mediated substrate cleavage 4155 7054 637 581 572 1499 1020 6671 6670 4209 PMC2729314__F2 Wnt signaling network 1499 2040 324 6010 4040 PMC2731267__F1 Some putative molecular mechanisms that underlie the antineoplastic activity of mesalazine 1956 324 59330 PMC2742086__F2 Functional and structural organization of migratory mesenchymal cells 998 5879 387 2932 8650 324 PMC2753833__F4 Transition to endocycles in Drosophila 983 324 990 PMC2754156__F4 LPS signal transduction via the MyD88-independent pathway 3929 929 7189 PMC2754696__F1 CIE and CDE pathways showing lipid content and regulatory molecules 6714 382 998 30845 PMC2756045__F4 LKB1-AMPK pathway: metabolism and growth control in tumor suppression 998 324 1499 4133 PMC2763495__F1 Metabolic pathways of growth and proliferation 5728 4609 3939 5163 11113 1977 PMC2763507__F1 Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses 627 572 4082 1499 3727 PMC2764635__F8 Comparison of growth factor receptor signalling: This figure shows a comparison of ERK signalling from the EGF and Insulin receptors 4118 1950 5894 1398 2885 1956 PMC2769196__F4 Acromegaly pathogenesis and treatment 2778 5449 2691 1019 1021 8091 PMC2771939__F1 Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Signaling in Immune Cell Functions 6010 27040 998 PMC2773638__F4 Coordination of extracellular and intracellular signaling regulates cytoskeletal dynamics and axon formation 627 387 5908 998 5879 2932 324 PMC2794709__F2 O-GlcNAc and phosphate regulate the insulin signaling pathway at the plasma membrane 8473 3667 5163 PMC2795248__F3 Anti-inflammatory effects of EPAC in VECs 6010 9021 6774 PMC2796203__F1 Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer 7049 1950 7046 998 6010 11171 2932 7018 PMC2802426__F1 Molecular mechanisms that regulate ionotropic glutamate receptor distribution during hippocampal mGluR-LTD induction and expression 5662 4131 23237 PMC2802426__F2 Schematic model of molecular mechanisms underlying regulation of gene transcription and protein translation during mGluR-LTD in postsynaptic neurons of hippocampal CA3-CA1 synapses 5662 29904 23237 4131 1938 6714 2475 1869 595 1019 1950 2885 2002 PMC2806029__F2 Ammonia detoxification pathway and mitochondrial sirtuins 23409 1373 5009 383 435 PMC2807212__F2 Hh and Wnt signaling pathways 55733 5727 6608 51684 324 1499 PMC2808316__F5 Metabolic model for Aspergillus niger 100996569 9118 4118 PMC2808458__F1 Toll-like receptor signaling in cell proliferation and survival 51135 3654 4615 7189 29110 3661 PMC2811646__F4 Molecular targets in NFKB pathway modulated by PEITC and SFN 2810 4513 7124 PMC2813054__F1 Changes in Akt signaling with differentiation of CD8+ T cells and co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1)-blocked highly differentiated CD8+ T cells 10219 940 5163 PMC2814429__F2 Regulation of autophagy and apoptosis 9140 10533 83734 64422 2475 9474 718 8772 PMC2815088__F5 Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine 3667 5728 23411 2932 7249 8473 10724 6009 2475 29904 1938 PMC2815894__F2 Network of ABA-induced stomatal closure 5183 5954 2638 5091 5879 10006 PMC2816010__F6 Effect of dasatinib on the BCR-ABL signaling pathway 613 9846 596 5805 1975 4609 1386 867 1398 4208 6714 9774 PMC2817430__F1 Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature 3652 727 4047 7108 50814 11161 10682 1717 1718 PMC2819346__F1 Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance 84803 4018 5183 5091 PMC2819352__F6 Relationship of GPAT4 to other enzymes in the pathway of de novo glycerolipid synthesis 84803 137964 4018 150763 5091 5183 PMC2824768__F4 Entry into an ICL repair pathway depends on the mode of recognition 7508 4921 4350 51455 PMC2825293__F2 Nutrient sensing machinery in K- and L-cells 80834 139760 2695 847 PMC2831839__F9 A proposed mechanism of MNTX synergistic effects with temsirolimus on inhibition of VEGF-induced angiogenic events 6714 2475 253260 5266 5163 PMC2837572__F1 Downstream signalling pathways of TNFA 8717 7186 8772 PMC2839260__F1 Schematic depiction of the signalling pathways stimulated by cholecystokinin (CCK) activation of the CCK1 receptor 885 1956 126669 2885 2475 9261 7867 1977 PMC2840217__F6 Antioxidant and phase II detoxifying enzyme genes in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells 2353 847 6647 4094 3725 9817 3006 4118 51199 2623 2041 2593 3565 2937 4117 100131060 5548 2645 9049 10538 2875 PMC2840217__F7 Changes in cell cycle regulation in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells 914 5925 367 472 1111 4692 7153 PMC2841835__F1 Host defence signaling pathways in Caenorhabditis elegans model 10399 1612 5163 207 208 6446 7166 PMC2847476__F3 Immunoregulatory Functions of mTOR Inhibition 6965 940 1236 5728 10365 11040 50943 PMC2860204__F4 Integrin signalling at focal adhesions 2534 6714 2885 2549 9846 1398 PMC2861953__F2 Altered signaling pathways and mouse models of thyroid cancer 5979 7253 4914 5728 5908 PMC2863215__F2 Regulation of mTORC signaling networks 1950 1956 3667 2475 64798 5163 5898 8491 7249 6009 PMC2864659__F6 APE1 has dual roles in redox and DNA repair 4968 3131 7018 1958 PMC2869521__F4 Solid tumors activate the NFKB pathway to maintain cell survival 2475 1540 5899 29110 PMC2872883__F3 Small cell lung cancer 6955 5747 10000 329 5290 330 598 3551 7185 7187 4790 7189 5743 4846 5970 595 PMC2877703__F1 Anabolic and catabolic pathways regulating skeletal muscle mass 3479 6009 5337 2475 1999 PMC2889494__F3 Protein components of the pheromone response network constructed by the PCST approach 116985 23594 7018 59272 375757 110740339 1233 PMC2894449__F1 Stages of apoptotic cell engulfment and associated cell signaling events that regulate each stage 2621 391 929 948 1378 3920 PMC2895369__F1 High-flux and low-flux systems of electron transfer pathways 2242 2876 2879 PMC2901643__F2 Putative signaling components in fungal mating interactions 5551 7018 998 PMC2901871__F7 Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis 51808 25929 50628 54960 79760 79833 8487 PMC2906469__F4 Targeting GSK3B pathway may be highly beneficial for curing oral cancer 1956 2475 324 PMC2908393__F3 Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy 4035 53353 23621 PMC2910015__F4 General view of the species-specific regulation of histone homeostasis 4863 7884 983 10043 PMC2913512__F2 G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery 53836 6010 4193 2002 PMC2914561__F1 Translation control of gene expression 2475 83939 1977 26523 PMC2915669__F6 Model showing the interorganellar flow of acetyl units in C 5132 26136 11113 48 PMC2918459__F1 Biosynthetic pathway of ω3 and ω6 polyunsaturated fatty acids (PUFAs) 355 9415 4512 4513 3992 54898 PMC2918880__F1 Schematic depiction of selected core elements of the unfolded protein response (UPR), featuring the components measured herein (; ; ; ) 22926 83939 7494 596 PMC2919228__F6 Systematic Analysis of Essential Genes Reveals New Regulators of G protein Signaling 998 6010 84188 PMC2924648__F3 Directed cell migration 1794 5728 324 5058 5817 1956 PMC2932530__F9 Redox regulation of the PI3K/Akt signaling pathway 5728 5266 5163 572 PMC2934865__F2 Hypothetical model for SUMO regulation in NFKB pathway 7189 8772 4615 8717 PMC2939266__F3 Dopamine-sensitive signaling via adenylyl cyclase (AC), phospholipase C (PLC), and phosphatidylinositol-3-kinase (PI3K) systems 1813 5728 5163 2475 1977 8231 PMC2939308__F1 Activation of PPARG and PTEN Cascade Participates in Lovastatin-mediated Accelerated Differentiation of Oligodendrocyte Progenitor Cells 4922 718 5728 1019 6667 6663 4155 PMC2943975__F1 TOR signaling never gets old: Aging, longevity and TORC1 activity 3091 7428 405 7249 7248 6009 92335 2475 64223 29904 27250 1977 1975 1938 PMC2944409__F6 Calcium Signaling Pathway (KEGG, Kanehisa Laboratory in Kyoto University, Japan) with vinclozolin altered genes indicated 90550 5481 5350 613 952 PMC2945562__F8 Summary of signaling pathways for cPLA2A activation and eicosanoid production stimulated by engagement of C 6850 847 4512 4513 4615 PMC2949647__F1 Structure and signaling machinery of the Met receptor 2549 2885 1398 998 5879 2113 PMC2949900__F4 Cell Cycle Pathway: Differentially expressed genes involved in the cell cycle are shown in pink 10055 5885 4087 4088 4089 6502 7851 5266 699 9184 5111 983 1017 1869 PMC2950025__F1 Models of mitotic exit in yeast 983 324 10518 10276 999 PMC2956794__F1 Targeting DNA repair proteins for cancer treatment 4255 183 7508 472 7507 5893 7518 5888 5111 3981 675 672 7515 3980 2237 3978 PMC2958230__F1 Effect of TBCD and its Regulatory Interactor Arl2 on Tubulin and Microtubule Integrity 907 6903 402 6902 6904 6905 1155 PMC2963059__F2 Non-canonical Wnt pathways 23002 998 51701 607 1499 PMC2966110__F8 Stbd1 participation in glycogen metabolism and Stbd1 structure 2548 11337 23710 8987 101448070 PMC2972642__F2 REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy 3643 387 1938 2147 4208 2002 595 PMC2975945__F2 Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS 7018 7076 5292 PMC2976306__F7 Changes in gene expression in central carbon metabolism (A) and ergosterol synthesis (B) 2734 2819 2820 5230 2023 2026 4191 48 3417 2078 23481 PMC2988877__F3 The DNA Damage Response: Making it safe to play with knives 545 5111 9156 641 PMC2991311__F4 Systems Biology Approach Uncovers Cellular Strategies Used by Methylobacterium extorquens AM1 During the Switch from Multi- to Single-Carbon Growth 6120 11113 1431 4118 4277 790 100 3250 7454 PMC2997336__F1 Model illustrating the signaling pathways activated by optimal DA and hyperdopamine 2932 1020 1499 PMC2999229__F1 Hypothetical model for the molecular signaling pathways of vasculogenic mimicry in tumors and anti-vasculogenic mimicry (VM) therapy strategies 1969 51083 84707 4313 3398 4838 PMC3004842__F2 Flux-sum intensity in Z 1896 11113 4118 1431 PMC3009898__F6 Model for an alternative Okazaki fragment-processing pathway in vivo 2237 1763 80119 3978 PMC3011268__F2 Regulation of Wnt signaling in Xenopus CNC 5754 7481 7204 729 PMC3014093__F3 Upper panel 3978 7515 7486 7518 PMC3014256__F3 A-Kinase Anchoring Proteins: Getting to the heart of the matter 6478 10014 4775 PMC3019561__F2 Mitochondria and the synthesis of phospholipids 283871 5091 1040 PMC3023527__F7 Schematic summary of the results showing the consequences of mPGES-1 mediated PGE2synthesis for LPS-induced neuroinflammation 3553 7099 3603 PMC3024731__F2 Examples of the signaling role of Cdc42 in selective tissue cell types 8178 998 3630 114034 PMC3030591__F7 Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte 2669 1017 472 545 355 637 836 94005 9081 5728 PMC3033173__F2 LMP1 in promoting survival in PTLD 3718 3654 5971 1386 8717 PMC3035636__F1 Targeting Metabolic Remodeling in Glioblastoma Multiforme 3099 4609 3939 3417 PMC3037521__F2 Selective elimination of messenger RNA underlies the mitosis–meiosis switch in fission yeast 7248 7249 5187 7018 PMC3037835__F5 Major pathways of lipid metabolism in yeast 2820 2237 3422 84706 1040 84249 5266 1442 5091 5337 4284 151056 PMC3047086__F9 Suggested modes of the involvement of Nrf2/ARE in the regulation of AML cell differentiation 9817 7421 4094 2353 1386 3725 PMC3047798__F3 Wnt signaling components regulate ubiquitylation 324 1499 6477 PMC3061041__F1 Negative regulation of the IMD pathway 5817 1956 8772 5426 23118 1540 PMC3062054__F4 Roles for Growth Factors in Cancer Progression 1956 100187907 613 3815 5163 PMC3067333__F5 Schematic presentation of Nag PTS and parts of the central metabolism of R 5805 3250 2539 1896 5160 5162 PMC3068086__F5 Coordinately up-regulated cell cycle genes in CD8+ T cells from the VIR group (VIR versus BDL) illustrated in cell cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) 114569 5111 1017 1022 PMC3070659__F1 Representative axon regeneration-regulating pathways discovered in genetic model organisms 2353 9021 5728 1270 PMC3073350__F1 Linking actin dynamics and gene transcription to drive cellular motile functions 999 6010 6722 PMC3075242__F6 Differential Expression of MicroRNAs in Tumors from Chronically Inflamed or Genetic (APCMin/+) Models of Colon Cancer 3416 1398 4763 572 472 637 3725 4609 581 4149 4193 79629 51176 5933 324 8772 23385 1401 PMC3076058__F2 Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction 387 83605 57154 889 998 PMC3077214__F1 Signaling pathway components used to test gene–compound interactions 1950 6608 5728 6697 3725 PMC3077393__F8 GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin B Gene 7200 5617 2624 7252 PMC3082271__F5 NVN for Putative CHS-Mediated (CHS4) Medicarpin Biosynthesis.Nodes in the network resemble individual genes, and the connecting edges represent coexpressed links 4548 412 4758 PMC3082499__F5 Anti-apoptotic mechanisms of Akt 7249 7248 6009 2475 4193 581 572 PMC3082833__F1 During innate immune activation via LPS-LPB-TLR4, a number of factors of the coagulation pathway are activated, creating the cooperative immuno-coagulative response 7018 324 929 7099 4615 6010 7189 23118 257397 10454 6502 8195 5971 PMC3091668__F4 Putative TLR signal pathway 59307 695 114609 54472 3654 57506 7189 7187 23118 10454 29110 3661 3665 7099 51284 4615 51311 7098 7096 PMC3109512__F3 Proposed role of CnPlc1 in pathogenicity-related signaling in C 2828 847 1431 1255 3084 PMC3109867__F1 Insulin/iGF-1 signaling pathway is conserved across phylogeny 3479 5728 5163 6446 208 PMC3110863__F4 Regulation of MeCP2 expression by Bdnf 627 2885 2549 4204 PMC3114084__F2 Titin domain arrangement in the cardiac sarcomere and connectivity within a mechanical signaling network 2273 2274 4077 PMC3115623__F5 Major intracellular signal transduction pathways for CRF1 and CRF2 receptors 627 6714 2885 PMC3116035__F3 A) Schematic outline of mitochondrial and metabolic pathways connected to the PPP in hepatocytes 952 6648 367 1499 637 2475 6925 727 174 4025 355 PMC3116122__F1 PI3K pathway activates different processes that regulate proliferation, apoptosis and migration 1956 5163 6010 4193 572 5728 2475 PMC3117879__F2 Implications of Relationships between Human Diseases and Metabolic Subpathways 5053 6955 7015 100187761 PMC3118679__F1 The networks of factors (genes product, hormones, and metabolites) potentially involved in the regulation of milk protein synthesis in lactating bovine mammary tissue 3643 3667 23395 4553 6009 2475 3906 1977 1999 1998 1938 29904 6194 1448 2001 6777 3717 PMC3118679__F8 Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 240 relative to −15 d postpartum 6513 6247 23395 7157 7248 3906 7249 1448 6009 1938 1432 29904 6194 1977 6124 6146 PMC3118704__F3 Toll-like receptor-4 (TLR-4) signaling via MyD-88-dependent pathways 3929 7099 929 4615 7189 1958 PMC3119514__F3 IL-1 and TLR activation pathways 3554 7097 114609 4615 3654 54472 10010 7189 29110 23118 10454 PMC3119514__F6 RNA polymerase II transcription complex 6667 7185 3383 PMC3120109__F4 Schematic illustrating that AMPH indirectly stimulates dopamine (DA), glutamate (glu) and BDNF (B) release and stimulation of D1 dopamine, glutamate, and TrkB receptors, respectively, in the striatum 273 627 5999 5894 5728 5163 PMC3121779__F15 Protective effects of OxPLs against acute lung injury and endothelial barrier dysfunction 3929 929 55872 998 6010 1499 PMC3123739__F8 DNA Repair Deficiency in Neurodegeneration 472 9656 9025 9156 5888 7517 7516 5893 55775 7486 2237 3981 3978 641 7173 PMC3124126__F1 Molecular signaling cascades which normally control mTORC1 activity and may become dysregulated in B-cell lymphomas leading to aberrant mTORC1 signaling activation 5728 5163 7248 7249 6009 PMC3132641__F3 Proposed mechanisms mediating the effect of the (pro)renin receptor (PRR) in metanephric kidney development 4041 1499 1956 5979 6402 PMC3133824__F2 Mechanisms for import and export of proteins to and from the nucleus 10763 5901 4922 4151 PMC3136910__F2 Proposed model of ATF2 regulation of Ha-Ras signaling 1386 7175 1105 5966 PMC3138544__F1 Targets and therapies for B-cell non-Hodgkin's lymphoma (B-NHL) within the context of the 10 hallmarks of cancer and overlapping oncogenic signaling pathways 4067 695 6009 2475 3550 PMC3139189__F2 B1/Fak/Src integrin signaling, cell survival, and suppression of anoikis 2534 6714 2885 3611 5163 90427 1612 572 PMC313952__F6 Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals 1950 1956 9541 867 171013 2885 6654 PMC3140958__F6 Protein interaction maps of the defined ratio clusters, (A) [G1_S]#3 and (B) [G1_S]#2 2521 404684 23062 100379198 4351 PMC3146004__F4 Pathway assignment of the important genes based on KEGG 6502 4118 699 5111 1017 4661 23632 6667 8480 3458 8454 6500 399 4838 PMC3146512__F2 Genome Sequence of a Mesophilic Hydrogenotrophic Methanogen Methanocella paludicola, the First Cultivated Representative of the Order Methanocellales 1356 5447 7939 PMC3148240__F1 Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin 1950 1956 6714 387 5728 PMC3148288__F1 ERM proteins are scaffolds for cAMP signaling pathways 920 3932 1445 382 PMC3149084__F2 Single-run analysis of the yeast proteome by LC MS/MS 5238 55276 2203 2026 27040 5131 50 4190 48 11113 3417 3418 PMC3151497__F3 MAPK signaling pathway 4803 1380 4351 1956 59330 2353 6717 5810 4342 4609 3727 1386 7124 2645 355 4149 929 51701 1950 PMC3154935__F4 Influence of Stochastic Gene Expression on the Cell Survival Rheostat after Traumatic Brain Injury 5829 5998 10724 6714 7852 102 2246 284 1950 6386 3717 2885 6774 1398 369 4342 572 6772 6722 814 PMC3156300__F9 Prolactin-Stimulated Activation of ERK1/2 Mitogen-Activated Protein Kinases is Controlled by PI3-Kinase/Rac/PAK Signaling Pathway in Breast Cancer Cells 5617 5618 3717 5163 2885 PMC3156782__F2 Wnt/Beta-catenin signaling pathway generated by Ingenuity Pathway Analysis (IPA) 11197 4193 51701 4609 6925 8313 960 PMC3159114__F10 Role of GPx-1 in modulating apoptosis 355 637 2876 581 PMC3159301__F1 Pathways involved in platelet hyperreactivity in DM patients and therapeutic targets 3667 2638 7408 4512 PMC3161734__F3 Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii 5226 6120 132 183 4311 5183 5132 65057 162417 55750 383 5009 435 PMC3165056__F4 Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity 8717 7187 7186 7189 8772 3661 3665 PMC3166203__F12 Upstream kinases and redox-sensitive phosphatases in NFKB activation 7124 5266 5163 5728 PMC3166354__F1 Cellular and Molecular Action of the Mitogenic Protein-Deamidating Toxin from Pasteurella multocida 4851 1499 23236 1956 5163 1050 3716 3717 5292 387 5879 998 PMC3166463__F1 RIGI-like receptor pathway 23586 57506 23118 3661 3665 10010 7187 7189 PMC3166778__F1 PI3K signalling pathway: The phosphatidylinositol 3-kinase (PI3K) signalling pathway begins with PI3K activation by receptor tyrosine kinases after growth factors or insulin stimulation 5728 7249 572 581 4193 9776 PMC316768__F1 Model of somatic sex determination in C 6382 6383 9672 29896 PMC3168773__F2 Functional relationship linking Crb proteins to the SWH pathway 92359 4087 4088 4485 PMC3170448__F5 Simply comparing and contrasting the expression patterns of perturbed genes was inadequate for deciphering the MAPK pathway response dynamics 5880 11072 7534 7216 4133 2252 PMC3173800__F2 Two major pathways to caspase activation in vertebrates: the death receptor or extrinsic pathway, engaged by the indicated members of the TNF receptor family on the cell surface, and the Bcl-2-regulated mitochondrial or intrinsic pathway 8717 581 8772 331 PMC3176897__F1 Summary of fatty acid and glucose metabolism 4023 948 95 847 PMC3177269__F4 Proposed model for a common symbiotic signaling pathway between actinorhizal plants and legumes 51199 55746 79902 108348016 PMC3180440__F2 Regulation of the early myogenic transcriptional program by the kinome 2695 5163 207 983 1019 1021 1017 2308 PMC3181488__F2 Signal-receiving cell—modulation of developmental signalling by intracellular trafficking 6608 5817 1956 867 55614 4040 4041 PMC3185585__F1 Remodeling the cellular secretory pathway to support enterovirus replication 8729 375 417 PMC3185786__F1 Survival pathways controlled by Tax 5728 5894 5970 PMC3187864__F6 Axon viability depends on coordinated endocytic trafficking and signaling 83547 4803 11127 PMC3188704__F1 Regulation of cell migration by signaling endosomes 998 6010 7074 382 1956 6714 PMC3189826__F1 p130Cas and p140Cap signalling involved in migration and invasion 2064 999 1445 6714 1398 PMC3190105__F1 TLR-dependent and JAK/STAT-dependent signaling pathways in microglia 7096 7097 10333 3717 3716 114609 6772 4615 3654 3665 7187 7189 10010 3661 3460 3459 PMC3193400__F2 Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets 5970 5971 4504 1571 2876 PMC3199966__F1 Schematic biosynthetic pathways for the major phospholipid (Kennedy Pathway) and sphingolipid classes biosynthesized in mammalian cells and observed in MALDI IMS of mammalian tissues 84803 1674 6611 5091 10400 780904 283871 PMC3202514__F1 Maturational changes in fatty acid and carbohydrate metabolism gene expression 2821 130589 2597 3033 PMC3208628__F5 Integrated Transcriptome and Binding Sites Analysis Implicates E2F in the Regulation of Self-Renewal in Human Pluripotent Stem Cells 4899 2487 2260 2263 4040 2264 2767 2786 2776 6237 324 1499 6885 5590 7531 5879 23433 57575 57526 5594 1952 5598 6596 6602 6603 6657 6605 79923 3070 PMC3209136__F2 Biosynthetic pathway for UA and flocculosin 2196 120114 2195 PMC3209350__F1 Synthesis, utilization, and regeneration of glutathione and regulation of mTORC1 activity 2876 7248 7249 6009 PMC3213966__F3 Regulation of cardiac hypertrophy by AKAP complexes 4775 6010 10014 6262 PMC3219211__F1 Small-molecule inhibitors in the ubiquitin–proteasome system (UPS) 1642 9101 7874 8078 8239 9097 8883 PMC3219972__F3 Effect of carbon exchange and reversibility constraints 1362 100 1896 PMC3225017__F2 c-MET signaling adaptors and mediators 3082 867 2885 6714 2549 6774 1398 PMC3227097__F6 Network of core pathways that mediate commitment of cells to the division cycle 6714 4609 6497 8976 572 3551 6502 PMC3227454__F2 Epidermal growth factor and aging: A signaling molecule reveals a new eye opening function 3630 1950 3643 1956 5163 65095 PMC3228910__F2 Expanded representation of the KEGG pathway "colorectal cancer" 324 100526820 4018 572 4436 27040 PMC3232027__F2 Identification and development of mPGES-1 inhibitors: where we are at? 4512 5228 5226 PMC3233269__F9 G protein-coupled receptors (GPCR) trigger dissociation of GA and GBG heterotrimeric G proteins upon agonist stimulation 5091 4018 4026 2548 387 6010 PMC3233564__F3 Mammalian MAPK signaling pathways 4149 4094 7186 PMC3236823__F2 Evolution of the mTOR pathway 3643 5728 5163 6446 7124 2932 7248 7249 8925 6009 5337 8491 2475 253260 PMC3238080__F2 Regulation of intracellular signaling by antiepileptics and modulators of glutamate, acetylcholine, and melatonin systems 4666 1938 627 PMC3245119__F2 Non-canonical Wnt-signaling pathway 8168 2778 54331 10454 23118 5728 9761 5350 5481 6262 7908 PMC3245719__F1 Bioenergetic regulation of cellular physiology and gene expression 549 2876 27349 581 23411 5266 5728 PMC3246422__F10 PP-associated modulation of inflammatory chemokine production and repair-related processes in keratinocytes through EGFR system 7039 3458 1956 6010 6774 PMC3247287__F8 Profiling Insulin Like Factor 3 (INSL3) Signaling in Human Osteoblasts 122042 5331 6714 1499 PMC3248866__F2 HPV 16 E5 enhances growth factor signalling pathways 1950 1956 6714 581 PMC3249369__F4 Three MAPK pathways in yeast share common components and also contain pathway-specific factors 998 6010 7295 PMC3249681__F8 Simplified diagram depicting the proposed signaling pathway of the CB1 activation that inhibits the activity of small GTPase RhoA to inhibit motility of PC-3 cells 5879 998 387 PMC3250525__F3 Visualization of the quantity of genes differentially regulated by Gamma-tocotrienol (GT3) and Alpha-tocopherol (aTOC) using the KEGG cell cycle pathway 4087 4088 1874 4089 4193 348235 699 9184 5111 1017 2147 990 4661 6502 999 1869 8317 4999 23595 PMC3254631__F5 MiRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols 1950 3929 2335 929 54331 2245 28964 1398 5829 324 PMC3255710__F2 Fine adjustment of autophagy by the AMPK-mTORC1-Ulk1/2 kinase network 7249 6009 8408 9706 9776 2475 55626 PMC3256462__F1 Basic signaling pathways and relevant targets together with their inhibitors associated with endocrine resistance Estrogen receptor alpha (ER) and the growth factors (esp 1950 6868 8205 6714 PMC3260001__F1 Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells 6714 2885 998 6010 5728 841 1370 5163 6093 2475 4193 PMC3265067__F7 Phospholipid biosynthetic pathways 5833 10400 5091 5662 PMC3267701__F1 Amyloid precursor protein (APP) processing pathway 7276 4035 1956 PMC3269678__F2 Signaling pathways leading to transcription factors activation in response to UV-radiation 9817 83939 4094 5970 1386 2002 6722 4312 PMC3270265__F3 Glucose metabolism in cancer cells 57103 2147 2597 2023 PMC3270265__F5 Regulation of cell death by glucose metabolism 2475 572 8772 PMC3271653__F1 Testosterone signaling pathways 1956 6714 367 PMC3276621__F2 Pathways for the synthesis of glycerolipids and their subcellular localization 5091 5266 283871 84249 9489 3630 4099 1040 84706 9162 2195 PMC3280674__F1 Fatty Heart, Cardiac Damage, and Inflammation 4023 948 338 7038 PMC3281071__F4 RNA-seq Reveals Novel Transcriptome of Genes and Their Isoforms in Human Pulmonary Microvascular Endothelial Cells Treated with Thrombin 1950 1956 6654 6010 1356 2002 6908 PMC3281420__F1 Schematic overview of the multifunctional roles of c-FLIP in the TRAIL-triggered apoptosis pathway as well as activating various anti-apoptotic and cell survival signaling pathways 8772 7186 7185 PMC3284544__F5 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis 8772 1616 7186 8717 637 56616 27429 PMC3287012__F1 Signaling through CD44: hyaluronan binding to a receptor such as CD44 or RHAMM will cause a conformational change in the receptor 960 4280 4018 102 6868 7046 3082 6420 6010 11140 5728 PMC3287489__F2 Cell cycle pathway and the significant genes on cell cycle-related miRNAs 4193 9184 991 5111 1017 1022 6502 PMC3289531__F2 A, Hepatic BCAA metabolism 2475 3667 1431 471 718 355 7038 4023 PMC3296254__F5 Arginine metabolic network 384 1357 1358 383 PMC3296254__F7 Lysine biosynthetic pathway 54903 3417 3418 PMC3296807__F1 Oncogenes and tumor suppressors associated with the regulation of autophagy 5728 7248 7249 6009 2475 64223 572 664 1869 581 PMC3303613__F1 Signaling pathways in the pathogenesis of nasopharyngeal carcinoma (NPC) 5728 1848 1499 324 1019 2353 999 1956 4609 7015 PMC3304564__F1 PI3K/AKT signaling module and cross-talk with other pathway 5728 7249 581 6009 PMC3313462__F4 Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes 3098 3099 7054 8568 PMC3319314__F3 APE1 role in DNA base excision repair (BER) 7515 2237 5111 PMC3319470__F1 Coenzyme Q10biosynthetic pathway and electron transport role in the mitochondrial respiratory chain 23590 57107 84274 10229 51004 51805 51117 57017 2110 4538 4535 4539 4536 4519 4537 4540 4541 PMC3321553__F2 Coregulation of gene transcription by p53 and Smad complexes 4087 4089 4193 4088 PMC3322137__F3 Pathway-Based Evaluation in Early Onset Colorectal Cancer Suggests Focal Adhesion and Immunosuppression along with Epithelial-Mesenchymal Transition 387 7408 5728 1398 572 PMC3322580__F4 Enrichment and submodularization of cell cycle in terms of E3-mediated regulatory modules 6343 6622 5885 440823 1641 991 5111 929 8315 4193 PMC3323126__F3 Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus 960 1956 4485 60485 9113 26524 PMC3324026__F1 Annotation of the insulin/TOR network in Apis showing methylated and differentially methylated genes 367 238 5728 5163 2475 3091 253260 7248 7249 6009 1975 673 PMC3328893__F1 Physiological and pathophysiological stimuli regulate tonicity-responsive enhanced binding protein (TonEBP) in diverse cell types 650 3603 367 PMC3332287__F2 Wnt signaling pathway participated in the activation of hepatic stellate cells 51701 5624 324 4089 4088 4040 4041 9350 6500 9978 9475 PMC3337681__F7 Putative inhibitory pathway of inflammatory signaling events by CA 7097 7099 3654 6850 6714 5163 1386 PMC3342110__F1 Signaling pathways important for C 3630 208 207 6649 PMC3342348__F1 IL-1 signaling in the tumor microenvironment 7189 10454 4615 7124 54472 PMC3342359__F1 Three types of autophagy and cellular and molecular events in an autophagic pathway 9140 10533 83734 64422 PMC3342643__F5 Diacylglycerol kinases in immune cell function and self-tolerance 4615 51135 7189 3654 5163 2932 PMC3343135__F2 Differential expression of mRNA and proteins encoding factors in the Notch signaling pathway 8650 23462 23385 PMC3343703__F1 Heme metabolism 2235 340451 7389 130749 7390 4151 210 PMC3350790__F1 Dmrt genes integrate sex-specific, spatial, and temporal cues to induce sexually dimorphic differentiation in restricted groups of cells 6955 7409 6010 PMC3355730__F2 Co-expression of genes involved in lignin formation across species 790 6497 4602 7204 1312 PMC3355838__F3 Wnt signaling pathways 387 847 85451 51701 1499 4040 4041 324 PMC3355930__F1 Prostaglandin E2 (PGE2) biosynthesis and signaling 4512 5226 5228 PMC3356080__F4 Factors and molecular mechanisms that influence ecdysone synthesis and the timing of critical weight attainment 4087 7249 7248 5728 PMC3356354__F10 High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes 2885 2534 27040 3932 5163 867 10125 3702 8915 10892 1493 PMC3357504__F2 Translation initiation control during growth factor stimulation, cellular stress, and cellular physiology 5728 83939 1998 3190 7248 7249 2475 6418 1977 PMC3359746__F1 Several growth factor signals activate cell membrane receptor tyrosine kinases leading to activation of downstream interacting signal transduction pathways (PI3K/AKT, RAF/MAPK, and MTOR) 2475 126669 2885 5163 5728 7249 7248 6009 572 596 6194 4609 PMC3360100__F2 Examples of signal transduction pathways in astroglial cells following P2X7R activation 3603 24145 6010 PMC3360162__F4 Synthesis of eicosanoids and their actions in mast cells 4049 4512 4513 5226 4050 PMC3361329__F2 Signaling pathways of TNFAlpha-induced hepatocyte death 8717 7186 8772 83737 581 331 PMC3362209__F1 RIP-1 in programmed necrosis 27035 8772 5624 23118 257397 1540 PMC3370283__F2 Somatic Activating PIK3CA Mutations in CLOVES Syndrome(A) Demonstration of the PIK3CA c.1624G>A somatic mosaic mutation in participant CL4 5290 5728 5163 207 2475 PMC3370396__F6 NSAIDs perturbed genes related to thrombosis, fibrinolysis, and PAR signaling 7018 324 5340 2335 5327 PMC3382540__F1 ERK signaling pathway controls T-cell activation and anergy 920 940 7535 PMC3390457__F1 Neuroprotective signaling pathways employed by Erythropoietin 2057 2056 3717 PMC3391329__F3 Proteome coverage of the KEGG ‘Insulin Signaling’ pathway 1379 867 355 25886 2308 3630 3643 7249 6009 572 2475 1977 2885 PMC3393719__F8 Yeast Magmas Ortholog Pam16 Has an Essential Function in Fermentative Growth That Involves Sphingolipid Metabolism 11331 100996949 5131 8819 PMC3397315__F4 Summary of ion channel targets of the GSK-3 pathway 3785 5163 100170220 PMC3408425__F9 Systems-level regulation of metabolic genes by Met TFs 1040 25913 4191 50 4549 6052 4550 6053 2876 2987 6054 6055 3417 PMC3408426__F10 Metabolic genes regulated by the Met TFs 5091 9489 50 4550 6053 6054 6055 3417 PMC3410580__F2 Structure and interacting partners of p62/SQSTM1 2475 4077 7189 9817 PMC3412962__F4 A, Differential expression of proteins involved in glycolysis and TCA cycle 3939 197257 1737 3945 9373 PMC3418849__F10 TrkA signaling pathway 4803 10818 6714 1398 2549 2885 2475 572 6416 5608 4133 5604 2308 PMC3422477__F1 Apoptosis affects cell signaling pathways that control lipid synthesis and energy metabolism 57103 47 2194 7249 472 PMC3426550__F6 SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR 283871 7038 8471 1442 4284 5091 PMC3428242__F1 Simplified schematic representation of the mammalian target of rapamycin (mTOR) signaling pathway.Notes: Red, pathway inhibitor; Green, pathway activator; Blue, mTOR complex protein.Abbreviation: NOS, not otherwise specified 7249 7248 5728 6009 253260 2475 64223 6010 PMC3430547__F4 TORC1 and nitrogen regulation 4881 4882 4883 54903 84232 PMC3433910__F1 Putative scheme of the cellular metabolism in the hydrogen producing arachaeon T 353 283871 9049 5091 100187907 PMC3434475__F1 The canonical translation pathway in eukaryotes with the ribosomal recycling and initiation phases shown in detail 6059 1999 1997 10209 4553 1998 2001 1983 1975 PMC3437319__F2 Regulation of mammalian target of rapamycin complex (mTORC) signaling networks 3667 5163 7248 7249 6009 1977 PMC3441384__F4 Nanoparticle-induced autophagy 2475 9474 9140 10533 4553 PMC3442837__F1 Regulation of phenotypic transitions in the fungal pathogen Candida albicans 998 27010 3084 PMC3444501__F4 Therapeutic Effects of Astragaloside IV on Myocardial Injuries: Multi-Target Identification and Network Analysis 3815 4942 6300 4846 1950 5881 4311 2597 367 683 653361 1956 7039 3105 1636 23604 1432 4312 2022 959 1401 183 2147 10855 59272 6403 6651 3717 213 6774 4763 PMC3445701__F7 Alzheimer’s Disease pathway from KEGG 351 23385 3416 4023 572 842 836 637 8772 317 6622 100506742 22926 7124 2932 840 PMC3448918__F8 Proposed mechanism for D10G-mediated suppression of NFKB-regulated gene expression 7097 7100 7099 PMC3467356__F1 Regulatory network analysis of the top genes with SNPs with p<0.001 using MetaCore’s shortest pathway algorithm (GeneGo Inc.); the nodes that are circled are the genes of interest 6667 1958 3394 5800 7421 PMC3469232__F1 Cholesterol is converted to pregnenolone by cytochrome P450scc inside steroidogenic mitochondria 706 10857 6714 PMC3469602__F4 Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells 7124 355 637 2021 56616 27429 790 PMC3469622__F1 Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells 2885 3932 1445 3702 102724566 8915 5966 2353 3725 920 940 PMC3469673__F1 Activated CD47 is a proximate regulator of multiple cell survival and cell death pathways 961 6714 2638 664 5163 PMC3475164__F1 Biosynthesis of glycerophospholipids 95 5091 5053 10400 5662 100379198 PMC3475405__F3 Blood–brain barrier (BBB) transport in homeostasis of brain AB 3553 3569 348 PMC3478427__F2 Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act 367 387 1719 PMC3479319__F1 Wnt signaling cascadesWnt signals can be transduced either through the canonical pathway (colored in pink) or different non-canonical pathways 6010 2475 1499 324 3725 PMC3480285__F1 Metabolic Map of Phenolic Metabolism in the Inflorescence Stem of Arabidopsis.The main pathways involved in lignin biosynthesis are framed with a bold black border 1431 6750 1312 PMC3480285__F5 A Systems Biology View of Responses to Lignin Biosynthesis Perturbations in Arabidopsis 1431 27040 1232 1312 1230 65057 PMC3481051__F3 The different main molecular pathways that are involved in neuronal stress response 7428 57510 9798 208 207 7018 PMC3481527__F3 CB1 cannabinoid receptor signalling and regulation of neural stem/progenitor cell proliferation 6714 6774 5909 2932 5080 PMC3482395__F2 Canonical biogenesis pathway and mechanisms of miRNA deregulation 4609 367 29102 3178 54487 PMC3489783__F3 Representative KEGG pathway change of Endocytosis 382 2147 3949 22944 2060 30846 1956 30844 1121 8027 51028 84313 51652 PMC3493385__F2 RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways 3479 9798 54704 5728 5163 207 208 6497 6446 100 9437 9436 PMC3494149__F6 VANTED integrated pathway map of quantitative regulation of metabolites and enzymes of primary metabolism under nitrogen limitation in Chlamydomonas reinhardtii 2695 5817 100307120 5064 11113 4191 4118 7390 PMC3500781__F1 Two different pathways could bypass DNA damage causing stalled replication forks 56852 5111 51455 118027463 PMC3502886__F1 PI3K/Akt/mTOR pathway regulates central carbon metabolism 5728 11113 2475 PMC3513219__F2 XRCC1 is instrumental in base excision repair (BER) of small oxidative lesions and a related mechanism for the repair of single-strand breaks (SSB-R), both caused by ionizing radiation 4968 7515 3980 11284 5423 PMC3513309__F3 Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine 920 940 7006 100124696 3932 3702 5879 5778 2002 930 974 2885 998 5728 2475 PMC3514880__F3 Genome sequences of wild and domestic bactrian camels 867 2308 3630 5163 5164 3643 2475 2885 PMC3515549__F7 Screening the Budding Yeast Genome Reveals Unique Factors Affecting K2 Toxin Susceptibility 79053 11043 4500 27072 PMC3519537__F1 Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing 175 8573 6863 167227 6009 717 207 253260 7808 29904 667 4609 PMC3519537__F5 Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing 790953 7248 5728 6009 717 253260 6194 29904 PMC3523093__F1 Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches 1950 7124 3726 3727 1386 6722 3667 637 572 581 PMC3527701__F2 Mammalian N-end rule pathway.,,, N-terminal residues are indicated by single-letter abbreviations for amino acids 197131 23304 23352 51366 11101 123803 55093 1356 PMC3528566__F2 Carbohydrate metabolism and ATP synthesis 2475 9776 10533 1431 2597 PMC3528620__F4 Chemokine Signaling Pathway from the KEGG database (ID: mmu04062) overlaid with log2 fold change values for genes differentially expressed between DBA/2 and C57BL/6 at day 14 5581 5590 387 PMC3528779__F6 Global Effect of Inauhzin on Human p53-Responsive Transcriptome 1017 275 472 545 637 4609 836 64065 7249 5728 64326 PMC3529762__F11 Illustration of GnRH signaling pathways necessary for FSHB induction 6722 1386 2488 PMC3531074__F3 Network exploration options 7404 26136 7276 PMC3535180__F1 Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? 4512 3553 1401 PMC3536343__F1 MTORC1 signaling to the translational machinery 5163 5728 7249 7248 6009 64798 1975 6194 29904 27250 1938 84232 4553 PMC3539548__F1 Host cell machinery gets activated during influenza infection and leads to trigger Signaling pathways 2147 83939 1386 PMC3541279__F2 Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury 1392 759 51083 572 1384 2021 351 7186 8717 6955 149998 329 4792 7054 PMC3544567__F2 Differentially expressed genes within the Wnt Signalling pathway 324 8454 6500 387 PMC3544775__F3 Laminin-211 in skeletal muscle function 2885 572 581 PMC3547893__F1 Interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility 6667 10013 156 2357 PMC3552512__F3 Oncogenic signals regulate each stage of translation 2475 253260 1977 4609 1938 11201 PMC3555267__F2 Typical MAPK signaling pathway 6010 2002 9261 PMC3558412__F1 Diagrammatic overview of the late stages of the HIV life-cycle 5976 6059 7251 5548 PMC3560469__F2 Angiotensins in the RAS 183 59272 1636 1611 PMC3563272__F4 Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT 95 5091 3630 5662 283871 PMC3567827__F1 Hh signal transduction in Drosophila and mammalian systems 6608 100188011 2719 2239 10082 2619 156 374654 51684 8405 PMC3568185__F1 PGE2biosynthetic pathway 4512 4513 5228 5226 PMC3572392__F4 Almost all Theileria annulata proteins involved in glycolysis and citric acid cycle were identified in the study 140805 2821 2597 5230 4967 5236 1431 5091 2271 5183 PMC3576254__F5 Pathway analysis 4117 324 847 3952 4827 5091 1610 5978 4763 2316 3725 355 1616 4149 23385 PMC3579143__F8 The regulatory role of IRAK-M in TLR-IL-1R signalling 4615 3654 7189 23118 1977 8651 PMC3579325__F3 Selected pathways from enriched injured (EI) versus non-enriched (i.e., STD housed) injured (NI): demonstrating calcium signaling importance 858 613 5062 1610 PMC3586519__F1 Schematic illustrating the cancer utilization of the metabolic pathways 2539 3939 5163 PMC3586680__F1 Schematic diagrams of WWOX structure and its role in signaling 51741 6714 2066 860 324 PMC3588000__F1 Biosynthesis of Phosphatidylethanolamine (PE) 5833 5091 10400 5662 PMC3588864__F7 Possible mechanisms of estrogen/androgen action in the prevention of NAFLD/NASH 2147 7351 3156 PMC3597360__F4 Pathways leading to actin polymerization in the myogenic response 7408 387 998 6714 PMC3623255__F3 Metabolic pathways in the periplasm and the cytoplasm 2572 5493 283871 PMC3623872__F5 Nutrigenomics in Arma chinensis: Transcriptome Analysis of Arma chinensis Fed on Artificial Diet and Chinese Oak Silk Moth Antheraea pernyi Pupae 355 3630 7249 7975 1977 2885 8178 2475 5163 253260 3091 1975 7248 6009 673 PMC3625555__F3 Neuroactive ligand-receptor interaction and calcium signaling pathway 7200 4018 5729 7430 367 90550 5350 858 613 952 PMC3626870__F4 Arsenic-mediated disruption of PI3K/AKT signaling pathway 5728 5879 998 4193 572 2475 PMC3627964__F2 Proposed roles of Msi1-like (MSIL) proteins as regulators of the nutrient- and stress-sensing signaling pathways in fungi 998 339287 4440 4881 PMC3628288__F2 Diagram of two potential molecular pathways of serrated neoplasia 673 3845 4292 PMC3632131__F1 Shared network structure by non-small lung cancer pathway in KEGG and reconstructed co-expression networks using the CCA and GLASSO methods 5578 5605 595 369 5579 11186 5582 4893 3265 3845 1871 6655 2885 1869 6654 5925 1870 5336 5295 8503 207 1950 23533 842 7039 10000 572 208 2309 PMC3633815__F1 MTOR signaling pathway 5163 7249 7248 6446 6010 6009 8408 9776 PMC3634068__F6 Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters 1652 6256 1551 1559 1591 211 1555 47 1244 PMC3634440__F1 Gene regulatory networks of plant transcription factors (TFs) in plant abiotic stress responses and abscisic acid-dependent gene expression 54861 4602 2077 7808 5640 6651 PMC3645661__F1 An overview of signaling by the EGF family (with EGF and EGFR/ErbB1 as example) from cell surface down to the nucleus (without taking into account endocytic trafficking and recycling of the receptor) 1950 26018 1956 867 122809 2885 5728 2475 7018 PMC3645678__F3 Involvement of Cdc42, Rac1 and RhoA in vesicle trafficking, cellular transformation, invadopodia formation and metastasis 998 5337 6010 5879 PMC3646015__F6 Developmental Gene Discovery in a Hemimetabolous Insect: De Novo Assembly and Annotation of a Transcriptome for the Cricket Gryllus bimaculatus 6608 51684 474168 PMC3649098__F3 Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis 7018 1401 3603 4513 7412 3383 PMC3649461__F1 Signal transduction pathways of the amino acid (AA) response (AAR) 83939 468 1386 PMC3658475__F2 P53/MDM2 regulation 4193 355 581 545 472 7508 PMC3660063__F3 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response 7249 7248 6009 64798 2475 1977 1975 572 1499 581 PMC3660063__F4 Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response 2885 4763 3667 5728 5163 7249 7248 6009 64798 64223 2475 8408 PMC3666381__F2 Metabolism in pluripotent stem cells 2821 7167 2597 2731 157739 23464 PMC3666437__F5 Regulation of upregulated miRNAs on the downregulated mRNAs in antigen processing and presentation pathway and p53 signaling pathway 3458 7124 811 567 821 693210 1508 920 1021 1019 5978 545 4609 613 4857 94005 64065 2475 406942 PMC3666507__F4 Cross-talk between muscle (pink) and tendon (dark grey) cells in Drosophila 6259 474168 1499 PMC3679475__F1 Inflammatory adipokines suppress insulin signaling resulting in insulin resistance 5163 5728 2475 2308 PMC3683326__F3 GenMAPP schematic of cell cycle pathway genes 6502 5266 699 9184 5111 1017 1022 4661 23632 PMC368431__F1 Sample view of a VisAnt application 84188 100187761 11043 PMC3688269__F2 Dysfunctional telomeres activate upstream checkpoint PI3 kinases, such as ATM (ataxia-telangiectasia mutated) or ATR (ataxia-telangiectasia and Rad3 related), - () 472 545 1019 1021 PMC3689254__F3 EGFR activation of the Ras/Raf/MEK/MAPK pathway 1956 2885 2353 1386 PMC3690345__F2 Metabolic crossroads of iron and copper 7036 9973 6647 331 475 540 538 1356 3240 55240 10063 2242 2395 PMC3690365__F2 Pathways that control levels of macroautophagy 22863 2475 9776 10533 9140 9474 PMC3696710__F1 Constitutive components and the transduced mechanisms of Hh signaling pathway 6608 2619 51684 2932 2737 PMC3701596__F3 Sleep specific effects on protein processing and the unfolded protein response 11316 7432 4397 258010 100187907 22926 3240 468 10054 PMC3702256__F1 Pathview: an R/Bioconductor package for pathway-based data integration and visualization 9126 7272 7157 472 6502 4171 8318 PMC3703662__F6 Proposed model for NV-128-induced casapase-independent cell death in OCSCs 2021 2475 581 PMC3705551__F2 Major catabolic and anabolic pathways in mammalian cells 3939 4118 1431 11113 6523 PMC3705708__F1 Hedgehog Signal Transduction Network 6608 51684 91653 374654 PMC3708893__F5 Oral Neutrophil Transcriptome Changes Result in a Pro-Survival Phenotype in Periodontal Diseases 355 8772 7186 8717 6497 29110 1616 637 56616 27429 PMC3709411__F1 Illustration of important relationships between metabolome, proteome, and genome in cancerous cells 4609 3417 5223 3418 2271 3939 PMC3711327__F7 A model for the regulation of transcriptional induction of ICL1 and FBP1 by the PIPTC 5266 6908 2203 PMC3711692__F5 Staufen-mediated mRNA decay 6780 5976 27067 100187761 PMC3713161__F7 Summary of the effects of increased dietary fat plus ethanol on the AMPK pathway and expression of enzymes involved in fatty acid synthesis 3077 95 47 PMC3714590__F5 Known and Predicted Interactions between the Products of the 352 Genes Bound Preferentially by Pol II in Neuroepithelial CellsAnalysis was performed using STRING with a medium confidence score of 0.4 and all interaction methods available 90525 147111 60 9618 6010 1956 4313 2806 9247 5226 9973 PMC3717064__F1 NK cell activating and inhibitory receptors and their downstream signaling molecules 2885 27040 5091 3903 10859 3932 7535 6850 2534 PMC3717945__F3 Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance 2475 126669 2885 3667 4763 5728 7249 7248 6009 2932 64798 8408 PMC3720859__F4 Capacity of Aptamers to Trigger Immune Activation in Human Blood 3929 351 4615 114609 54472 4026 2002 7908 PMC3721281__F2 Asparagine-linked glycosylation pathway 79868 8813 29880 56052 2821 10195 29929 84920 91869 PMC3724896__F4 Differentiated Neuroprogenitor Cells Incubated with Human or Canine Adenovirus, or Lentiviral Vectors Have Distinct Transcriptome Profiles 472 759 2196 641 332 4085 2177 5888 PMC3729625__F5 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling 6649 6647 6648 PMC3730337__F1 HDACi and DNMTi target the MM cell 324 545 472 PMC3732602__F1 TGFB signaling 7048 5894 6010 PMC3735707__F3 Maternal factors required for oocyte developmental competence in mice 5728 9365 7083 717 5241 367 4342 699 4661 914 9126 PMC3737373__F9 RNAi Mediated Tiam1 Gene Knockdown Inhibits Invasion of Retinoblastoma 1950 7074 960 4131 PMC3742697__F8 Proposed model of Cr(VI)-induced carcinogenesis 2932 2475 1499 3952 PMC3746082__F4 Diabetes mellitus induced regulation of skeletal muscle 7124 2638 5879 440514 998 83939 2475 3479 PMC3758473__F5 The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease 9575 4609 472 PMC3762275__F2 Recognition of particulate and soluble Beta-glucans by dectin-1 and signal transduction in macrophages and DCs 7097 10333 6850 5091 51135 4615 64170 114548 3654 7189 3603 6714 PMC3763758__F1 HIV-related neuropathic pain pathway 627 7852 4513 PMC3766375__F3 Fat side of Prostate Cancer 3156 47 2475 2194 4609 3939 3417 4118 5728 PMC3770247__F1 Hedgehog signaling pathway, a morphogenic signaling pathway important in embryogenesis, tissue differentiation, cell growth and development 6469 6608 1445 PMC3777336__F4 Differentially expressed genes (DEGs) related to the cell cycle 9126 10274 10735 1874 4087 4088 545 472 4193 4089 6343 6502 324 991 9184 995 994 993 1017 1022 999 1869 1870 1871 8317 10926 4999 23595 5000 5001 23594 PMC3779382__F6 Therapeutic modulation of EBV infection and associated signaling pathways 2475 613 4193 PMC3791614__F1 The interactions between the control of the cell cycle and the expression of specific ligands for activating NK receptors in various pathologies 545 1019 5111 8480 1017 PMC3798767__F5 p53 regulated developmental pathways 11197 2549 1398 324 7175 4117 9261 6422 351 2885 10454 4089 8650 4099 PMC3804751__F7 Model showing the cRAF-dependent modulation of DC responses by TcES 7099 7097 4615 3586 PMC3811932__F1 Growth factors, insulin, nutrients and energy status regulate the activation of the PI3K/Akt/mTOR signaling network 5163 3667 8491 5728 7248 7249 2475 6009 572 253260 64223 PMC3812160__F7 Transcriptome-Wide Mapping of Pea Seed Ageing Reveals a Pivotal Role for Genes Related to Oxidative Stress and Programmed Cell Death 57716 7316 90678 PMC3815023__F2 Functional Networking of Human Divergently Paired Genes (DPGs) 26228 55620 4089 6502 991 699 9184 5111 1017 990 4661 4809 22827 10523 57461 151903 4116 55696 9716 PMC3820535__F7 Modeling Integrated Cellular Machinery Using Hybrid Petri-Boolean Networks 998 7018 8466 2819 4149 PMC3825669__F3 KEGG “cell cycle” pathway relevant to NRF1 target genes 9126 10274 10735 5885 1874 4089 4193 6502 991 699 9184 5111 994 993 729 1017 1022 983 324 990 4661 999 4998 4999 23595 5001 23594 PMC3825669__F6 IPA “regulation of eIF4 and p70S6K signaling” pathway relevant to NRF target genes 3667 2885 1977 6194 1998 10605 1999 4553 51247 2000 PMC3826841__F1 Regulation of the G2/M transition in the yeast cell cycle 3240 10519 10518 PMC3826850__F1 The Drosophila Toll and Imd pathways 8772 10522 5966 PMC3830618__F2 Homeostatic plasticity at the Drosophila neuromuscular junction 998 6616 4397 PMC3830884__F4 MAP kinase signaling pathway of sugarcane infected by S 11043 6761 2739 998 PMC3834778__F5 Networks of shear stress-induced OA progression 3553 581 4312 331 PMC3837323__F1 PI3K/Akt/mTOR signaling pathway 6502 4193 572 7249 7248 6009 64798 9776 5879 387 5897 5896 1975 PMC3840081__F2 Estrogen-induced ER-mediated pathways of vascular relaxation 2638 387 7834 PMC3840609__F5 Gonadotropin-releasing hormone (GnRH) signaling pathway containing genes that are represented in the Partial Correlation Information Theory (PCIT) network “growth at the onset of puberty” 759 4313 998 685 1956 160851 PMC3848109__F3 TGF-ß fibrotic pathway 5340 7939 4087 4089 4088 PMC3848785__F3 Schematic diagram of the known PtdEtn biosynthetic pathways 84249 100379198 907 PMC3852343__F3 Oxygen-regulated COX subunit isoform switch in yeast and mammals 9377 1537 1329 PMC3853752__F3 Co-expression network of 106 genes associated to the FA metabolism in P 6667 6647 316 PMC3854349__F1 Biochemical adaptations of mammalian hibernation and naturally induced reversible insulin resistance 3667 5163 5166 PMC3870072__F3 Two reversing pathways between the vehicle and baicalin groups 3265 126669 2885 23440 108348016 759 847 4208 998 PMC3875720__F4 Upregulated Genes Encode Key Enzymes in Central Carbon Metabolism.Steps in the glyoxylate cycle (A), gluconeogenesis (B), and oxidative pentose phosphate pathway (C) are shown 5105 4142 2203 6886 PMC3875949__F1 Regulation of metabolism in maligant gliomas 3099 2597 1956 47 355 2744 PMC3879958__F1 Regulating the Regulator: Post-Translational Modification of Ras 5894 4763 9610 7074 5900 PMC3882437__F4 Perturbed pattern of genes in the peroxisome proliferation activator receptor (PPAR) signaling pathway by DEX administration (ethanol plus DEX vs 4199 4023 1376 4312 7350 3611 7316 PMC3888822__F2 Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways 920 998 387 PMC3889573__F1 HOG signaling pathway in C 466 2819 358 PMC3889573__F2 Ras, cAMP/PKA, and MSIL signaling pathways in C 2828 339287 4440 998 5879 3084 PMC3889573__F3 Ca2+/calcineurin, Rim101, and Pkc1/Mpk1 MAPK signaling pathways in C 5163 759 1255 6667 PMC3891361__F8 Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA 4851 108348016 2670 388585 PMC3897220__F9 Concept map of Whi5 function 4284 6886 100187761 11201 9081 PMC3897773__F7 Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling 6714 253430 351 PMC3898671__F2 Synthesis of the C5 isoprenoid precursors IPP and DMAPP 3422 3652 4597 PMC3908331__F9 KEGG mapping for cell cycle pathway 4352 4351 4118 9184 5111 1017 23632 717 PMC3913963__F5 Beta-adrenergic signaling modulates multiple cellular processes in tumor progression and metastasis 5906 6774 2475 572 PMC3916571__F7 The signaling transduction throughout integrin engagement by Cp aged under oxidative conditions 1356 6714 3716 3611 5728 5163 1399 5894 1499 PMC3916982__F2 Crosstalk of signaling pathways in breast cancer and the potential clinical therapeutic targets 1956 717 4763 5728 6009 4193 572 596 1977 PMC3920129__F3 TLR ligands/DAMPs, cellular location, and signaling in the vasculature 114609 4615 3661 3665 PMC3920756__F6 Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Oncogenes: Implications in Cancer and Pharmacogenomics 367 324 4118 PMC3924201__F1 Control of the core Hippo signaling pathway through interacting upstream modules 4485 60485 9113 26524 374 10207 154796 4771 23513 126374 PMC3925034__F1 Schematic depiction of some of the Ca2+ channels, pumps and exchangers involved in Ca2+signalling in mammalian cells 84876 4827 759 90550 6786 PMC3927937__F2 Mixed-lineage leukemia 2322 1499 324 404715 23476 PMC3928651__F2 Solving Glycosylation Disorders: Fundamental Approaches Reveal Complicated Pathways 54344 8818 8813 200185 1603 84920 84061 7991 1650 201595 3703 79053 79796 79087 10195 91869 79868 56052 29925 29926 4351 5373 PMC3929010__F10 Reactive Oxygen Species in Inflammation and Tissue Injury 3576 3383 7412 847 PMC3932036__F5 Akt signaling pathway 2885 3611 5728 11140 7248 572 7249 6009 79923 2475 1977 PMC3932252__F2 Autophagy is negatively regulated by the phosphatidylinositol 3-kinase (PI3 K)/Akt signaling pathway, which activates mammalian target of rapamycin (mTOR) in response to growth factors and also phosphorylates Beclin 1 7405 2475 9821 9776 8408 60673 84971 9474 10533 9140 83734 64422 23192 PMC3934763__F7 Insulin signaling KEGG pathway in adipose tissue 867 355 5163 5164 2932 3630 3643 7249 7248 6009 572 2475 2885 2002 PMC3934763__F8 PI3K-AKT signaling KEGG pathway in adipose tissue 2475 6009 7249 3667 5879 613 930 51074 5934 951 5728 572 5266 4193 PMC3939323__F3 A, JAK-STAT signaling pathway in interaction network 867 2056 8027 5292 3569 PMC3942026__F2 Evolution of a Cellular Immune Response in Drosophila: A Phenotypic and Genomic Comparative Analysis 9247 238 5879 1956 5817 1644 6693 121340 8027 4615 7275 7011 PMC3943226__F1 Apoptosis signaling pathway 7124 637 596 581 56616 57448 2021 790 6093 PMC3943829__F1 A scheme of metabolic pathway for cholesterol biogenesis 4598 7108 50814 10682 1717 PMC3944239__F8 Working model 81620 387 4998 7465 PMC3946543__F4 A Lipidomic Perspective on Inflammatory Macrophage Eicosanoid Signaling 5226 4513 7523 717 PMC3957730__F27 Glycolysis and gluconeogenesis in the mesophilic halophile Haloferax volcanii 2696 5805 3795 PMC3958334__F3 Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila 51003 4602 26523 2339 25804 5953 11140 29102 25843 51755 7871 6202 6235 6188 6152 9972 6189 10921 80763 10902 4236 5879 PMC3959161__F2 Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity 4023 8694 7038 355 5105 2638 PMC3959571__F1 Q6 biosynthesis in S 51117 10466 27235 57017 729 84274 10229 51805 PMC3962152__F4 KEGG Pathway database map showing Notch signaling including proteolytic cleavage and translocation of Notch followed by transcriptional activation of Notch target genes 8650 3280 388585 23385 PMC3973133__F6 Schematic showing actin cytoskeleton signaling pathways in adult hippocampal spines (see ) and the proposed mechanisms by which the glucocorticoid receptor (GR) affects actin assembly and stabilization 387 6010 998 PMC3973632__F5 Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues 4089 4193 6502 9184 991 699 5111 1017 1022 990 8318 4661 1869 8317 10926 23595 5001 PMC3976861__F2 Representation of the p53 signaling pathway map from KEGG 472 100187761 5901 581 64326 PMC3989954__F1 Crosstalk between mechanistic target of rapamycin signaling pathway and colorectal oncogenic pathways 3486 3479 1956 5728 2475 7248 7249 5163 6446 6009 6010 9776 1977 PMC3996671__F1 Ras and autophagy in cancer development and therapy 5879 2475 8408 9776 9474 10533 PMC4000654__F1 Physiological and physiopathological UPR activated pathways in B cells 22926 83939 468 7494 PMC4005604__F2 Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease 3652 998 6010 2475 5212 PMC4011321__F8 Putative pathway of the inhibition of LPS-activated inflammatory signaling by compound 7 7099 7098 7189 4615 6850 3654 5163 1386 PMC4014333__F1 Biosynthetic pathway of prodigiosin 5277 9487 5283 3042 93183 5281 23556 5279 9488 PMC4021393__F2 Activation of the "Role of BRCA1 in DNA Damage Response’ pathways in NCR versus CR samples 84126 545 472 9656 3458 466 580 571 4436 4292 4361 PMC4023866__F1 Bacterial effectors that target and manipulate the innate immune and inflammatory pathways 7099 10845 929 23118 10454 7189 PMC4024417__F1 Crosstalk between TGFB signaling and the renin-angiotensin system in fibrosis 59272 4087 4089 7018 PMC4028977__F1 Targeting inflammation: multiple innovative ways to reduce prostaglandin E2 5226 4512 5228 PMC4029595__F7 Proposed breast cancer signaling pathway based on the KEGG network pathway analysis of hypoxia-activated tumor cell migration 998 7414 2934 PMC4031321__F1 HIV induction by PKC activators and HDAC and BET inhibitors: NFKB is sequestered in the cytoplasm by IKB 6046 1869 7018 1025 23476 PMC4032668__F3 Simplified scheme of the DAF-16 signalling pathway in C 208 207 6446 6649 847 PMC4033011__F2 Possible pathways for LRP1-mediated AB uptake 4035 387 5879 PMC4041745__F5 Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome 5340 7422 5329 1398 331 126669 3611 847 5728 7409 1793 7204 2932 5879 998 9475 3265 3985 1981 8672 4088 3984 1977 PMC4054936__F2 Tonic regulation of vascular permeability 324 5879 5058 3082 7074 PMC4061530__F1 Schematic representation of the ribonuclease activity of IRE1 and RNaseL showing cross-talk between the paths catalysed by the enzymes 6041 6035 7494 PMC4061808__F4 Exercise activates a wide variety of intracellular signal transduction pathways to promote neurogenesis of granule cells from neuroprogenitors in the dentate gyrus 324 5629 6657 4760 PMC4065383__F2 Origins and removal of ribonucleotides in DNA 2237 727 246243 7150 5111 1763 9156 3630 PMC4065761__F1 Current models of the signaling pathway of the spindle assembly checkpoint (SAC) 991 9184 324 4163 699 PMC4066235__F3 microRNAs in Cancer Cell Response to Ionizing Radiation 1956 5728 574456 5163 4170 581 574452 PMC4066235__F7 microRNAs in Cancer Cell Response to Ionizing Radiation 8772 581 4170 841 840 842 PMC4071201__F2 p38 MAPK isoforms for drug resistance 3667 126669 2475 10743 5163 581 5091 PMC4081668__F2 Nuclear export of hepatitis B virus mRNAs 10763 4615 2597 PMC4085347__F3 Diagrammatic presentation of regulation of Keap1-Nrf2-ARE pathway 8452 3725 4094 6476 23633 PMC4086146__F1 Schematic model of mammalian heme homeostasis 571 107966124 2235 PMC4099309__F2 TNF and MAP kinase signaling pathways 7124 8772 998 23118 10454 29904 1641 2002 7186 8717 55312 PMC4099309__F3 TNF and MAP kinase signaling pathways 7124 29904 1977 1938 10682 2002 PMC4102778__F3 GSK-3 as potential target for therapeutic intervention in cancer 2885 3667 5728 5163 7249 7248 6009 64798 2475 253260 8408 6194 1975 1977 PMC4104517__F2 Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis 9927 581 204 10131 PMC4107617__F3 Group I mGluR-signaling pathway in immune cells 2353 3725 3553 PMC4113420__F4 PCNA and Msh2-Msh6 Activate an Mlh1-Pms1 Endonuclease Pathway Required for Exo1-independent Mismatch Repair 2956 5111 5378 9156 PMC4113681__F2 The Sprouty-mediated regulation of cell proliferation, differentiation, and survival irrespective of the Sprouty isoform and cell type 867 2549 1398 7016 5728 2932 572 7157 2885 4609 PMC4114643__F2 Osteoclast differentiation and bone resorption by Rho GTPases 998 5880 58480 4773 51119 7189 4772 4200 5879 PMC4114960__F4 Viral-Induced Rewiring of Host Metabolism Leads to an Increase in Fatty Acid Biosynthesis 100187761 2597 5723 26227 PMC4120074__F2 Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor 2931 27250 3084 253260 10397 3932 2475 367 1956 2956 2597 3815 581 5728 10763 PMC4120710__F6 Motility, Survival and Proliferation 6714 387 998 PMC4122349__F2 Serum miRNA Signature in Moyamoya Disease 3630 1975 5163 2475 253260 7248 6009 7249 PMC4123363__F2 The p38A/ERK cross-talk in colorectal cancer 637 23411 581 PMC4132015__F5 Notch, TGF-Beta, Wnt, Hedgehog, JAK-STAT and MAPK pathways 8650 3458 6500 3280 388585 7046 7057 4052 6667 387 23385 10468 4838 5308 4089 51701 847 324 1356 367 2619 7546 6608 51684 51715 790953 8027 3558 3562 5292 3569 2056 1956 PMC4133210__F1 Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells 22926 7494 83939 468 57761 PMC4136812__F4 Insulin, CCAAT/Enhancer-Binding Proteins and Lactate Regulate the Human 11Beta-Hydroxysteroid Dehydrogenase Type 2 Gene Expression in Colon Cancer Cell Lines 3479 2549 3667 2885 165 2475 7939 3065 3939 3291 PMC4137125__F3 Schematic representation depicting deleterious effects of overnutrition and obesity in the vasculature and targets for DPP-4i 7054 1803 3667 5163 790 367 7040 3383 7925 PMC4139483__F1 An Unexpected Journey: Lysine Methylation Across the Proteome 56950 79918 5970 4173 PMC4140250__F1 Schematic view of the sphingolipid metabolism in S 5004 5005 2237 PMC4148087__F5 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention 2475 5728 1499 PMC4148087__F6 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention 1956 5290 6714 3623 5728 5163 7249 6009 8408 PMC4148364__F5 Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database 1062 4199 3792 4541 4537 4538 PMC4148386__F3 MAPK signaling pathway 6722 2316 4149 355 1616 929 23118 51701 776 25780 3845 7046 7040 3164 PMC4157394__F12 Inhibition of protein synthesis by rocaglamides 5728 2885 7249 7248 6009 2475 1977 PMC4159007__F7 Epigenetics and the Evolution of Darwin’s Finches 51199 3458 7124 8454 6500 387 10468 PMC4159007__F8 Epigenetics and the Evolution of Darwin’s Finches 55486 8772 114609 3929 929 958 923 51135 1513 6769 PMC4159007__F9 Epigenetics and the Evolution of Darwin’s Finches 4286 1499 1638 PMC4162761__F1 Biosynthesis and Roles of Phospholipids in Mitochondrial Fusion, Division and Mitophagy 5091 84706 150763 1040 283871 PMC4163915__F11 Model is presented whereby serine phosphorylation of IRS-1 serves as a mediator of Ang II to inhibit insulin-induced Akt Thr308 phosphorylation 1839 3630 367 1956 2475 PMC4170139__F4 Late signaling events in de novo cytokine/chemokine production 2534 4067 5163 6850 9846 4615 2885 4118 7189 8915 2475 7124 27040 PMC4172307__F1 Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors 3073 355 2475 1977 5970 PMC4172469__F7 Estrogen Regulation of microRNAs, Target Genes, and microRNA Expression Associated with Vitellogenesis in the Zebrafish 10274 4087 4088 4089 2932 4193 9184 699 5111 993 1022 1021 1019 1017 8318 4661 1869 1874 8317 10735 6502 5266 PMC4177028__F2 Intracellular energetic units (ICEUs) 948 4118 203 204 PMC4177605__F3 PPAR signaling pathway from KEGG 5360 4023 4312 7350 7316 PMC4178034__F3 Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response 4615 7189 671 PMC4179613__F3 MicroRNAs expression profile in CCR6+ regulatory T cells 3932 867 2534 27040 2056 1019 4703 102724566 8915 PMC4182853__F1 The current understanding of p38D MAPK signalling and activation 1386 10682 5587 29904 1938 PMC4183925__F2 Metabolic pathway of insulin signalling pathway for unigenes by KEGG annotation 355 5163 5164 3643 3630 7249 6009 572 2475 1977 2885 PMC4186533__F6 Src family kinases in Gq- and Gi-coupled receptor signaling 2534 387 759 4067 PMC4196580__F7 B cell receptor signaling pathway showing the annotated and non-annotated proteins 933 971 6850 613 4067 29760 2638 8915 930 PMC4196580__F8 T cell receptor signaling pathway showing the annotated and non-annotated proteins 867 962 3932 2534 27040 3702 2885 1019 8915 940 PMC4201519__F2 Integrated microRNA and mRNA Transcriptome Sequencing Reveals the Potential Roles of miRNAs in Stage I Endometrioid Endometrial Carcinoma 5885 4089 1874 2932 4193 6502 9184 991 699 5111 993 1021 1019 1022 1017 1475 983 4661 990 1869 407055 8317 10926 4998 PMC4203832__F4 Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax 2056 57817 4082 6955 998 4296 85451 2002 1386 3725 3091 4609 PMC4221543__F1 The MAPK/ERK pathway 6714 5266 2475 1956 PMC4225589__F5 Plasmalogen-Biosynthesis Pathway and Associated PhenotypesPlasmalogen synthesis is a multistep process that involves several enzymes 84188 8443 5191 PMC4237243__F4 PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways 3014 672 675 5888 983 581 PMC4237243__F5 PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways 2475 672 675 3014 5888 581 983 PMC4238866__F1 The Snf1 protein kinase as a central player in the main glucose repression pathway 27010 5105 2203 PMC4238866__F10 Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae 27010 84232 54700 4553 PMC4238866__F3 Glucose activation of the cAMP-PKA pathway 5997 201626 27010 PMC4240652__F6 Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet 3718 126669 2833 7074 387 1398 PMC4243705__F4 CHROMOSOMAL INSTABILITY PATHWAY IN COLON CANCER 2885 7074 5900 5163 29110 6010 PMC4246027__F1 NEUROTROPHINS IN THE VENTRAL TEGMENTAL AREA: ROLE IN SOCIAL STRESS, MOOD DISORDERS AND DRUG ABUSE 627 4803 2885 7189 9618 2549 5163 PMC4248054__F1 Mechanism of oestrogen action 1839 1956 6714 PMC4252654__F1 MANNOSE METABOLISM: MORE THAN MEETS THE EYE 4351 5373 29926 29925 8813 8818 54344 9526 PMC4256494__F3 A, Cellular arginine metabolism and putative role of arginase in the development of renal fibrosis 435 5625 4942 384 PMC4260725__F2 Major signaling pathway regulation and core machinery of autophagy 9776 60673 9140 10533 83734 9474 64422 PMC4265444__F5 The sulfur assimilation pathway and the genes encoding the enzymes of the different biosynthetic steps 2877 2876 4504 PMC4266039__F7 Biological activities of triterpenoids and saponins in animals 6774 7852 2919 1956 4318 3383 596 PMC4268999__F2 PI3K/Akt signalling pathway 7249 5163 2475 5728 4193 572 596 PMC4275033__F1 Metabolic pathways that lead to the production of fatty acids and fatty acid-derived chemicals 196 84890 8772 1674 PMC4278335__F4 In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma 808 1950 1956 2475 5728 4193 100126306 382 2066 3949 1213 867 30846 2060 387 57154 23327 998 4734 10193 83737 11311 30845 91782 8027 51160 51028 84313 PMC4281841__F3 Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases 3667 10130 23071 2582 PMC4283519__F1 Signaling pathway interaction and effects of modulators: cGMP and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelet aggregation in patients with metabolic disorders 2638 7450 4512 3552 PMC4288261__F2 N-terminal tyrosine residues of SLP-76 on the canonical TCR signaling pathway 5335 2534 2885 3932 1445 3702 102724566 5966 2353 3725 940 PMC4298213__F1 Generalized central metabolic pathway adapted and modified from a previous study 11181 25796 5226 3073 2805 4190 6395 5091 4191 2806 6392 PMC4301092__F2 Examples of PTM-mediated biological processes 3276 4193 5763 PMC4303147__F4 Dominant negative LMP1 inhibits proliferation of CAEBV T cells 8717 5971 3665 PMC4303637__F1 Metabolic reconstruction for Candidatus Iainarchaeum andersonii genome 268 9242 23152 2242 PMC4306584__F7 Extracellular Hsp90 mediates an NFKB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment 6774 5970 4035 PMC4307112__F4 Differentially expressed genes in appetite control pathway between grass carp before and after food habit transition from transcriptome analysis 4852 181 7200 1812 8027 3953 3952 5360 51083 2744 PMC4315163__F4 G protein-coupled receptor pathway is involved in transmembrane signaling and diverse physiological functions including hormone signaling, regulation of cell contraction, cell migration, growth and differentiation 2885 2534 156 2922 PMC4322894__F1 CXCL12 is highly expressed in tissues like lungs, liver, and bone marrow and is also secreted by tumor and stromal cells 6387 7852 6010 998 1398 572 27068 1499 PMC4323240__F7 Macrophage Activities in Proliferation, Lysosome, and Phagosome by the Nonspecific Immunostimulator, Mica 4089 7851 5266 5111 1017 4661 23632 PMC4326572__F1 Main molecular pathways activated in the presence or absence of nutrients 6510 6009 8408 9776 55626 PMC4329310__F4 Detailed view of protein secretion pathway 7494 468 83939 9817 56886 PMC4329815__F3 Signaling pathways implicated in hyperstimulation of macropinocytosis and vacuolization of macropinosome-derived compartments 4803 5058 10006 382 28964 PMC4331626__F4 Depiction of various pathways that are known to contribute to eEF2K regulation in systems biology graphical notation (SBGN) activity flow format () 7249 7248 29904 1938 PMC4334071__F2 Insulin signaling in ovarian thecal cells and proposed mechanisms for selective insulin resistance 126669 2885 5894 2475 1583 1588 PMC4346946__F3 DNA damage-induced molecular responses for DNA repair 1386 8452 472 672 9656 3014 PMC4354324__F3 Multiple promising targets for regulating cancer metabolism 4199 2194 47 PMC4357785__F6 Important pathways in HCC Shown is the mTOR/AKP/PIP3 pathway that contributes to transformation of nodules into metastatic counterparts 2335 2690 286204 5894 5163 6010 2475 572 PMC4358941__F2 Comparative Metabolic Analysis of CHO Cell Clones Obtained through Cell Engineering, for IgG Productivity, Growth and Cell Longevity 11113 3939 4191 4118 PMC4365602__F7 This schematic shows the numerous pro-inflammatory mediators produced by peri-implant tissue and immune cells reacting to implant debris, which can negatively affect bone turnover 3606 3603 3553 PMC4367908__F2 The network of molecules involved in the control of VPC fate determination and the cell cycle in C 983 324 1017 79631 1019 PMC4368378__F1 PINK1-Parkin signalling 84749 9958 6015 192111 65018 PMC4376477__F1 Neuronal aggregates: formation, clearance and spreading 367 338386 3297 PMC4376961__F3 Schematic overview of autophagy machinery and its regulation by sphingolipids 60673 8408 22863 64422 10533 664 PMC4377205__F4 Gene interaction pathway 5318 5317 26136 51225 100 1431 PMC4381257__F1 Important ECM molecules and ECM receptors involved in cancer cell invasion 960 6010 3611 4318 4313 PMC4383161__F2 Integration of the 3 major pathways that regulate skeletal muscle mass 2475 2932 5111 PMC4383744__F2 Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape 1356 716 717 718 1380 1378 727 735 PMC4386721__F3 Signaling pathway map 2932 5728 5163 PMC4389820__F1 Major interconnected signaling pathways that regulate EMT 6608 3611 387 7189 1499 1000 999 PMC4393718__F2 EphA/ephrinA bidirectional signalling 6714 3717 1398 998 3611 6774 6010 6237 PMC4398932__F5 Putative KF inhibition pathway in macrophage-mediated inflammatory signaling events 7099 4615 6850 3654 51135 6714 PMC4400837__F2 RAS trafficking pathway 3550 23463 9986 PMC4402634__F3 KEGG pathway map for TGFB and MAPK signaling pathways 2444 6500 10090 1616 4838 1610 6722 4149 PMC4403552__F1 Fabric of signaling cascades can be activated by astrocyte Gq-GPCRs 998 156 157 1606 1445 2932 4082 PMC4403607__F12 Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity 581 2475 983 51755 595 1019 PMC4406223__F4 Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation 3667 6247 1506 PMC4407014__F4 An incomplete engagement of the TCR pathway differentiates BT-061 from other anti-CD4 mAbs 85451 920 940 PMC4414131__F2 Multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 2475 64083 399687 55737 8473 PMC4417677__F1 Cartoon illustration of the physiological roles and therapeutic implications of OCT1, SLC13A5 and ZnT8 in glucose metabolism, lipogenesis and insulin pathway 7038 4967 284111 PMC4428545__F2 Ratio heatmaps of identified canonical TCR signaling proteins that showed significant changes of phosphopeptide abundance for both types of stimulation (q value < 0.05; > 2–fold or < 0.5-fold) 2885 3702 920 940 PMC4428629__F1 Structure of an NDR/LATS Kinase–Mob Complex Reveals a Novel Kinase–Coactivator System and Substrate Docking Mechanism 2645 3815 81532 59272 PMC4432743__F8 ERK pathway signaling and outcomes in the M 7097 383 920 PMC4433321__F8 Hypothetical involvement of glucokinase (GK) and therefore glucokinase activators (GKAs) in the preservation and growth promotion of pancreatic Beta-cells 572 8660 3651 PMC4437805__F1 Wnt signaling pathways 4040 4041 6259 2932 387 5879 1499 147111 PMC4444590__F1 Mitochondrial complex I dysfunction in patients with BD could lead to increased release of superoxide anions, resulting in greater reactive oxygen species (ROS) production 100418973 114548 3553 PMC4445242__F3 Catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway 5335 2885 3702 951 952 920 940 PMC4445567__F5 Upregulated and downregulated genes in the cell cycle pathway after expansion in serum-free medium 4089 717 699 5111 983 1017 4661 999 PMC4445742__F4 Model depicting PPP1R12A/PP1cD in the insulin signaling pathway 3667 2885 5163 4659 PMC4447120__F1 AMPK is a negative regulator of the Warburg effect in Fumarate hydratase-deficient kidney cancer 7157 3939 5163 9817 8452 PMC4449903__F1 Visualized thrombosis network 5321 5596 3273 1611 7018 7409 7410 10451 PMC4457513__F2 Reelin-Disabled-1 signaling in neuronal migration: Splicing takes the stage 1000 7436 1600 10494 1398 8065 3984 2932 4131 998 PMC4457640__F3 Protein Cys map to functional pathways based upon percent oxidation 7284 10575 2194 226 847 7533 5478 4981 10073 6714 5901 PMC4461014__F5 Dual function of genes 27250 7097 7099 7124 4609 1499 7422 7078 7057 4313 4318 9350 25805 50964 324 23002 387 PMC4464398__F5 MAPK signaling pathway and neurotrophin signaling pathway maps 4803 4351 6722 4342 2316 3725 1386 100187907 8195 355 1616 4149 23118 51295 929 994 51701 10818 673 2885 126669 627 6957 572 399 8480 PMC4467136__F5 Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 3280 1840 171558 7157 8650 388585 23385 PMC4470864__F6 Pentose phosphate pathway (PPP) is associated with several cancer- and cell-proliferation-related signalling cascades 472 57103 2147 PMC4479845__F6 Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis 6351 1234 6908 6347 PMC4480196__F2 Pharmacologically targetable regulatory checkpoints of the mTOR pathway 7248 7249 5728 6009 3091 PMC4482087__F7 Rewired upstream transcription subnetwork in regulating the downstream pentose phosphate pathway in biomass conversion in Y-50049 yeast strain versus the wild-type 5989 9542 2203 64434 6886 5236 PMC4495601__F7 Novel drug target identification for the treatment of dementia using multi-relational association mining 1610 4803 50863 4351 2885 4342 2316 90459 7186 355 1616 4149 929 23118 51295 51701 PMC4500461__F2 Genome-Wide Identification of Differentially Expressed Genes Associated with the High Yielding of Oleoresin in Secondary Xylem of Masson Pine (Pinus massoniana Lamb) by Transcriptomic Analysis 4598 10654 4597 3652 PMC4505489__F8 NAMPT inhibition leads to alterations of different metabolic pathways in cancer cells 10135 5723 3418 2271 PMC4506078__F4 Adaptation of a Bioinformatics Microarray Analysis Workflow for a Toxicogenomic Study in Rainbow Trout 4089 4193 991 9184 699 5111 1021 1019 1022 10926 23595 3479 3630 5241 27040 4661 572 9985 10734 PMC4508827__F5 Toll signalling pathway of C 3949 6667 8772 4615 7189 58509 7481 PMC4509649__F3 Trade-Off between Growth and Carbohydrate Accumulation in Nutrient-Limited Arthrospira sp. PCC 8005 Studied by Integrating Transcriptomic and Proteomic Approaches 6120 84944 324 4133 PMC4512023__F4 PTGS pathway deregulation during colorectal tumorigenesis 4513 4512 5226 PMC4515825__F9 Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis 4191 8566 4190 PMC4515857__F3 PTEN localization and interactions with representative partners 5728 324 999 1060 6050 367 4157 PMC4517123__F2 Innate immune sensing of rhabdovirus infection 7187 10010 8772 23118 29110 3661 3665 PMC4519954__F10 MAPK signaling pathway 1610 2885 6722 4342 2316 3725 1386 355 1616 4149 929 23118 7189 51295 PMC4519954__F11 ERBB signaling pathway 1950 867 367 1398 685 3725 1839 4609 126669 2885 3084 9542 2475 572 10718 145957 PMC4519954__F13 Endocytosis signaling pathway 382 1950 867 4088 387 3949 5266 11311 30844 30845 8027 51160 7251 51028 84313 PMC4519954__F14 Chemokine signaling pathway 2885 126669 387 1398 1610 PMC4523312__F2 Protein interaction pathway produced by combining known protein–protein interactions from the literature 6010 3667 998 5728 572 6774 2475 596 4170 581 2353 595 1386 PMC4524120__F10 Proposed mechanism for the male-specific heart phenotype in insulin-resistant Pcyt2+/− mice 5833 948 5091 PMC4530548__F1 Antiviral Defense Mechanisms in Honey Bees 285175 8772 23118 27161 717 5966 PMC4531432__F1 Signaling pathway by which GUTK inhibited tumor metastasis in HCC (for abstract PS01-001) 6010 998 5879 619501 PMC4534763__F6 Identifying miRNA/mRNA negative regulation pairs in colorectal cancer 5885 4087 4088 4089 9184 5111 1017 1022 5347 999 990 6502 1874 23595 PMC4535673__F3 Profiles of central and oxidative stress response metabolism pathways of K 2820 2023 4191 48 50 1743 PMC4538064__F3 Insights into the molecular mechanisms of methylmalonic acidemia using microarray technology 6722 4342 4763 2316 7124 7186 2645 4149 355 1616 929 23118 472 836 5548 3792 PMC4539601__F4 Inferred network models capture oncogenic signaling pathways in melanoma 6770 1499 6247 545 5111 6714 673 7249 PMC4540601__F4 Differences in M1- versus M2-macrophage fueling reactions 948 1374 383 355 PMC4542378__F1 Signaling networks activated during primary KSHV infection as analyzed by Kinex antibody array and IPA 1616 8717 6714 7186 4193 3667 2002 1956 3643 2885 5163 1051 PMC4543607__F1 Major EDCF-mediated signalling pathways in hypertension and diabetes 4512 5226 5228 6010 PMC4544949__F1 The flow diagram represents the sphingolipid metabolism pathways both in mammals and in yeast 1674 6611 4284 PMC4545821__F5 2A-DNT on transcript expression, protein expression and nuclear signaling mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) peroxisome proliferator-activated receptor (PPAR) pathway 5360 4312 7350 100 3611 7316 PMC4546439__F1 Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened 2736 51684 2737 5727 6608 PMC4546755__F1 Known regulatory mechanisms of NRF2, highlighting miRNA-mediated influences 9817 196 8452 1026 406911 407024 100500918 407018 1728 PMC4549768__F1 DNA damage tolerance mechanisms 353497 5893 5888 118027463 80010 PMC4549768__F2 Regulation of DNA damage tolerance by proliferating cell nuclear antigen modification 353497 56852 5111 118027463 PMC4551270__F6 Genome sequence-derived metabolic reconstruction of Pyrobaculum yellowstonensis strain WP30 213 8772 5447 3045 100187828 50975 2271 PMC4551923__F8 Rad4–Rad23 and GG-NER E3 ligase function in DDR signalling and dNTP synthesis 8452 4549 6052 4550 6053 6054 6055 PMC4554646__F2 Proposed biosynthetic pathway of the prodiginines and the related 4- m ethoxybipyrrole, YP1 6341 5279 4199 3042 51604 PMC4560668__F2 WNT signaling in adult ovarian folliculogenesis 324 1499 8313 PMC4561407__F4 Translational control by ERK and mTOR 5163 2475 1938 PMC4562157__F5 Genes involved in metabolism (EMP pathway, TCA cycle, and inositol metabolism), rhizosphere adaptation, biocontrol, and plant growth promotion in SQR9 and their expression patterns in response to root exudates 210 48 55276 9942 100188863 266710 29 6722 1311 7067 PMC4563985__F3 Proposed mechanisms of activation of proinflammatory signaling pathways in IFN-mediated autoinflammatory diseases 3716 7297 6773 115004 57506 29110 3661 3665 25939 PMC4564008__F1 Regulation of Hedgehog signaling by ubiquitination 51684 5727 8454 PMC4564205__F3 Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49 2821 7086 6120 22934 2597 26027 641371 355 5132 65057 4118 5091 3156 4598 10654 2717 1431 11113 4597 3422 3652 2271 9453 1743 PMC4568555__F1 Key transduction molecules of ErbB signaling pathway known to regulate cardiomyocyte viability and function 2885 5163 2475 637 581 572 355 PMC4569842__F1 Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine 4953 11113 100996949 50 384 PMC4570227__F4 Metabolic pathways with compounds that can be used as molecular imaging probes for HP MRI 3240 5091 1431 1638 2744 2271 PMC4570614__F7 Dynamic differentially expressed (DE) genes were involved in T and B cell development as well as innate and adaptive immune response 3929 4615 8772 834 2353 3558 29760 3569 324 3586 3596 978 920 3458 7054 3594 PMC4574709__F2 Meta-Analysis of Microarray Data of Rainbow Trout Fry Gonad Differentiation Modulated by Ethynylestradiol 5885 1874 4089 4193 6502 699 9184 5111 1017 1022 5347 8318 10926 PMC4580081__F2 Interactions of chaperone proteins with Stat3 panel (A) and Jak2 panel (B) 3717 6770 11140 3716 PMC4580658__F1 Schematic diagram showing select signaling pathways in melanoma 2885 5728 2002 4609 1019 PMC4580722__F2 Regulation of autophagy by amino acids 8660 6247 5728 5163 8491 253430 7249 64798 60673 9776 8408 55626 7405 22863 5289 572 664 7942 PMC4581242__F1 UPRmt models in mammalians 8192 83939 27429 4899 10730 4708 2021 PMC4587736__F1 Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex 83992 85369 57464 2645 25843 4478 8317 4485 8428 6788 9113 81532 PMC4591505__F1 TCR-mediated integrin activation inside-out signaling 27040 5335 8631 PMC4592441__F4 Myc-regulated metabolic pathways in cancer 4609 3939 47 2744 6510 PMC4594611__F1 Hypothetical Model for the Transduction of Synaptic Stimuli to Long-Term Plasticity 11201 142 2475 PMC4595995__F3 HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling 54210 54472 4615 7185 51295 23118 10454 64127 59307 6761 7124 PMC4598307__F7 Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism 29843 158 100 PMC4601496__F1 Manipulation of neutrophil function by P 7097 4615 4118 PMC4607871__F2 Spindle assembly checkpoint and error correction 983 4163 991 9184 324 PMC4608483__F2 RNR regulation in S 6055 4550 6053 6054 4549 6052 PMC4609261__F1a Mapping the pathways of resistance to targeted therapies 3265 207 2475 367 PMC4609655__F6 MAPK signaling pathway 1610 26136 627 4351 2885 4342 4763 2316 2002 7124 7186 355 1616 4149 929 23118 7189 51295 51701 1950 PMC4611218__F2 Effect of orally administered foreign plasmid pDNA3 on proteasome degradation pathway 7319 7320 7334 54926 7322 7328 7324 10477 3458 6184 6185 6418 PMC4611285__F1 AKT and ERK signaling pathway 5163 4193 572 6772 PMC4612707__F5 Quantitative analysis of transcriptional levels of genes in the xylose metabolic pathway and the central carbon metabolism pathway 2203 6886 7167 5230 2023 2026 5105 100996949 5131 48 3417 4190 4118 PMC4615139__F6 Proposed mechanism of cordycepin-induced apoptosis and cell cycle arrest in NB-4 and U937 cells 993 331 1017 890 PMC4619206__F4 MAPK signaling pathway in CNVRs unique to the susceptible line 4803 627 5894 2885 6722 4342 4763 3727 7124 7186 355 1616 4149 4208 929 23118 7189 51295 51701 PMC4643087__F3 Ingenuity pathway analysis (IPA) revealed a key role for the Molecular Mechanisms of Cancer set of pathways 5091 1398 2885 867 3667 4763 2922 6010 4193 572 596 472 637 3725 4609 581 4149 54205 51176 5933 324 51684 8772 1616 23385 6608 914 PMC4656338__F2 Signal transduction pathway in HIF-1A regulation 5728 2475 7428 PMC4661376__F3 Actin signaling pathways and their association with brain disorders 1000 1499 4983 10011 10006 387 998 5063 56776 3984 2059 PMC4662454__F4 Targeting cancer by binding iron: Dissecting cellular signaling pathways 2885 4088 4087 4089 581 1386 2002 6774 6714 PMC4665974__F4 Overexpression of Human Fatty Acid Transport Protein 2/Very Long Chain Acyl-CoA Synthetase 1 (FATP2/Acsvl1) Reveals Distinct Patterns of Trafficking of Exogenous Fatty Acids 5091 5185 5183 PMC4669553__F3 PLD–PA involvement in lipid metabolism and signalling and impact on SA biosynthesis and signalling in plant defence 4018 2597 5091 4015 3250 4609 2744 95 4881 PMC4671457__F5 A, B) Functional analyses of target genes of the differentially expressed miRNAs in MAPK signal pathway 4351 6722 5894 4342 6693 3725 2002 4058 7186 355 1616 4149 929 51295 7189 51701 1950 5228 8213 9118 79633 7124 23118 PMC4677908__F6 Genomic and transcriptomic features of central carbon metabolism in C 6120 7086 5183 5091 440 2934 PMC4683180__F2 Tentative metabolic pathway model of membrane-bound electron transport in Methanoperedens 4519 2242 4548 2271 PMC4686024__F10 Comparative Transcriptome Analysis in the Hepatopancreas Tissue of Pacific White Shrimp Litopenaeus vannamei Fed Different Lipid Sources at Low Salinity 5360 4023 4312 7350 3611 7316 364 PMC4691064__F5a Transcriptomic Response to Nitric Oxide Treatment in Larix olgensis Henry 759 2444 6193 PMC4691085__F2 Crucial role of miRNAs in coordinating vast prostate cancer (PC) metabolic processes 5226 2539 2194 3156 7086 442909 2744 PMC4695001__F7 Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo 51083 367 4193 64801 PMC4696840__F3 miRNAs regulate cell metabolism by targeting key metabolic enzymes and multiple oncogenic signaling pathways 1956 3099 5728 57103 2475 5163 581 2744 3082 PMC4699681__F1 Signaling pathways activated in chondrocytes by fibronectin fragments 6714 3976 4312 4319 PMC4702617__F2 Deletion of the RIM15 gene on the metabolic profile of a laboratory strain during alcoholic fermentation 3098 2734 5347 7083 5132 PMC4703083__F5 The proposed biosynthetic and maintenance pathways for the metallocofactors of the class Ia (a), Ib (b), and Ic (c) ribonucleotide reductases 100306940 2160 54738 PMC4707198__F5 Schematic illustration of Hog1-mediated posttranslational and transcriptional hyperosmotic stress response pathway 157739 2819 6588 PMC4709516__F3 The Dendrobium catenatum Lindl. genome sequence provides insights into polysaccharide synthase, floral development and adaptive evolution 2444 101448070 51083 PMC4709637__F1 Exogenous avian leukosis virus-induced activation of the ERK/AP1 pathway is required for virus replication and correlates with virus-induced tumorigenesis 1610 627 4351 2885 5894 6722 2316 90459 6395 3725 7186 355 1616 4149 929 23118 7189 51295 51701 PMC4710172__F3 Promotion of cancer development and progression by NFAT 23523 4193 595 6423 PMC4710172__F4 Inhibition of the calcineurin-NFAT pathway at multiple levels 388324 4193 4513 PMC4711038__F9 Altered gene expression in the JNK signaling pathway during diapause 9618 7189 4478 23118 5879 PMC4716054__F1 TrkB-mediated signaling pathways and possible therapeutic targets in cancer 627 2885 5163 572 2475 PMC4716672__F3 Therapeutic Interventions to Disrupt the Protein Synthetic Machinery in Melanoma 2475 5728 11201 6908 27250 4553 PMC4718447__F1 Translational metabolomics in cancer research 768 3098 3099 9874 5236 3939 2194 5163 1374 PMC4720912__F2 Insulin signaling pathway 3643 5163 2885 7249 7248 6009 572 PMC4724957__F3 Metabolic pathway map of Parachlorella kessleri 65057 100187761 9776 22863 PMC4744895__F1 Schematic diagram of potential mild freezing shock signaling pathways in barley 867 2821 5091 PMC4749963__F2 A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells 6723 6611 4953 112483 6303 PMC4750973__F5 Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle 9045 4736 6160 11224 6129 6176 8178 1999 6187 5978 PMC4752785__F2 Scheme of the molecular mechanisms that ethanol consumption can influence during carcinogenesis of the mammary gland 1956 7039 273 2147 999 374 PMC4756744__F1 AVP-dependent signaling pathways in myogenic cells 551 9759 2626 PMC4774640__F3 Schematic representation of the ectoenzymes and transporters involved in the extracellular ATP metabolism 5167 84890 1080 PMC4779832__F2 Cross talk between ROS and NFKB signaling pathway 5971 4738 5970 PMC4784301__F4 Synthetic model of Plasmodium quiescence metabolism 3989 3988 1431 2271 6389 717 PMC4786284__F6 Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway 100188864 50846 6469 51684 PMC4791802__F5 Transcriptome and metabolic flux analyses in the central carbon metabolism in ST687 and ST1 (non-producer) strains 2203 6886 2819 5230 48 50 5185 100996949 4118 4190 127 51660 9049 10450 5493 PMC4795052__F4 Dysregulation of mTOR signaling pathway and mTOR in sleep phenotype of del 2q23.1 and SMS 7248 7249 6611 253260 6009 2475 1975 1977 6010 9776 1999 PMC4799531__F1 The central metabolic pathways leading to n-butanol in E 1636 3045 100187828 PMC4800317__F5 Canonical or classical NFKB pathway 114609 4615 54472 51135 3654 613 8717 7186 7189 8915 10892 83939 PMC4803054__F7 Models depicting the multifaceted role of Mte1 in RF repair and CO promotion 23137 79677 80010 PMC4813201__F1 Relevant intracellular signal transduction pathways of local anesthetic-induced toxicity 998 2534 2885 6714 6774 324 1499 4609 2353 3725 581 572 4193 8772 6608 PMC4816099__F2 Controlling a variety of extracellular and intracellular processes via the phospholipid code 8205 8717 387 PMC4818883__F2 Frequently mutated genes in ErbB signaling pathway 367 1398 685 3725 1839 2444 126669 2475 572 10718 145957 PMC4826512__F3 Targeting of the Wnt/Beta-catenin signaling pathway by Tat altered miRNAs 6714 3611 5300 1499 4193 51701 3065 6925 4316 22943 PMC4829595__F3 Representation of the cross talk among different pathways under water-deficit conditions 7054 54861 643418 PMC4836210__F7 Graphic representation of apoptosis and viral replication 8772 8717 83939 8739 572 PMC4836462__F5 Morphogens involved in BBB development and integrity influence signaling of common pathways 998 6010 3815 5728 4193 2475 595 1978 PMC4836665__F3 Differences in Whole Blood Gene Expression Associated with Infection Time-Course and Extent of Fetal Mortality in a Reproductive Model of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection 940 2534 6461 2885 3702 1445 9748 991 324 51343 5885 9126 PMC4850258__F5 Regulatory interactions of Usv101 9541 6667 2828 80146 PMC4854486__F1 Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis 259232 2696 2695 PMC4856261__F5 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes 7706 7186 8737 8772 7189 7187 PMC4856261__F6 NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes 1950 4803 958 100187907 114609 4615 3932 8772 8717 7535 7128 7335 5336 23118 257397 84433 10454 10318 3065 3066 PMC4859317__F1 Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan 2597 2932 2475 367 3569 7124 PMC4859987__F1 Terpenoid indole alkaloid pathway 3652 7055 11185 PMC4864533__F1 Signaling pathways downstream of Group I mGluR stimulation 7249 7248 6009 1977 PMC4867329__F2 Molecular mechanisms involved in glucosensing in the gastrointestinal tract 83756 80834 2695 PMC4872230__F5 Identification and Characterization of miRNAs in Chondrus crispus by High-Throughput Sequencing and Bioinformatics Analysis 4023 4312 7350 3611 7316 PMC4875603__F4 T Cell Receptor (TCR) signaling pathway activation in endometrium of UNINF fetuses 940 7006 100124696 2534 6461 3932 2885 6667 27040 1445 5879 2922 5778 2002 PMC4878678__F1 Genes in the MAP kinase signaling pathway (MAPK signaling pathway) identified using the KEGG-based pathway visualization tool 1956 3725 7186 8195 355 1616 4149 929 51295 PMC4887206__F6 Drosophila and vertebrate patched orthologs share a similar cis-regulatory architecture and gene regulatory strategy 4151 2178 10664 2736 2737 6295 PMC4889241__F4 p27 in cell-cycle regulation 2885 4176 6010 899 1874 PMC4889573__F2 cAMP intracellular signaling pathways in target cells of Treg suppression 942 941 9308 4772 PMC4898689__F8 Integrated Analysis of the Roles of Long Noncoding RNA and Coding RNA Expression in Sheep (Ovis aries) Skin during Initiation of Secondary Hair Follicle 4023 4312 7350 3611 7316 PMC4900217__F6 Metabolic reprogramming for NADPH production 2645 25796 5226 3242 64080 7086 6120 22934 5236 2147 6888 7167 5723 PMC4905241__F2 DNA damage-dependent regulation of E2F1 545 472 3276 1869 4193 317 596 581 80854 4738 10419 PMC4905454__F1 Cancer stem cells and signaling pathways in radioresistance 8544 572 581 2475 7039 1017 675 PMC4910040__F1 mTOR signaling pathway 6010 7248 7249 29904 1938 6009 1977 PMC4910072__F2 Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast 6319 2022 3099 64105 7008 PMC4910294__F2 Differentially expressed proteins involved in the pathway of Alzheimer׳s disease 351 3416 4023 348 572 842 836 8772 637 6622 7124 2932 840 PMC4924657__F8 Double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression 3565 3716 6778 3662 383 PMC4928090__F4 Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish 3575 10891 3796 5562 2311 6446 2310 9133 5506 867 901 1398 2998 5834 595 1026 6774 3586 356 5594 PMC4930918__F2 p53 regulates carbohydrate metabolism during glucose starvation 57103 2147 5164 9997 4199 27165 4200 PMC4933106__F1 Role of reactive oxygen species in age‐related neuromuscular deficits 57716 7018 847 3297 PMC4936551__F1 Proposed scheme to describe how are interconnected with Ca2+-pH signaling components in polar growing cells 8540 7054 3258 2241 PMC4937469__F11 Surviving problems during chromosome replication 9156 10926 5111 56852 118027463 5888 PMC4938759__F1 Mammalian target of rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction 207 64223 4318 64798 PMC4940079__F6 Differentially expressed gene distribution in the rno03320 pathway 5360 4023 4312 7350 3611 7316 364 PMC4943968__F3 KEGG pathway (pathways in cancer) analysis with predicated target genes from upregulated miRNAs 9126 1874 4089 4193 6502 699 9184 5111 1017 1022 5347 8318 4661 10926 4998 23595 PMC4943968__F4 KEGG pathway (pathways in cancer) analysis with predicated target genes from downregulated miRNAs 5885 4087 4088 1874 4193 6502 699 9184 5111 993 1017 983 1022 990 8318 4661 999 10926 4998 23595 5001 PMC4943968__F5 KEGG pathway (pathways in cancer) analysis with predicated target genes from all selected differentially expressed miRNAs 9126 1874 4087 4088 4089 4193 6502 991 9184 699 5111 1022 1017 4661 8318 999 4998 4999 23595 5001 PMC4959648__F1 Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia 4723 4729 4719 374291 1345 4535 4538 4540 PMC4965903__F1 IL-7RA pathway mutations provide potential targets for acute lymphoblastic leukemia therapy 85480 3717 5728 2475 PMC4966762__F1 Signaling pathways activated by ET-1 in cancer 1956 6714 389 387 3611 847 4512 4513 2932 1499 PMC4967820__F2 Gene repertoire for sterol biosynthesis in unicellular holozoans 6608 6713 7108 50814 51478 11161 10682 1717 1718 PMC4979452__F3 Ion homeostasis 51063 9241 9342 828 486 1080 PMC4981676__F1 Overall organization of JNK signaling pathways 998 5879 10454 23118 8767 PMC4982475__F6 Simvastatin and dLGG mediate formation of oxylipin mediators by regulation of MAPK-induced cPLA2 activation and downstream signaling cascades 3929 4015 4049 2002 PMC4994014__F1 IL-21 signaling pathway 3718 5079 604 3716 958 613 PMC4994014__F2 B-cell activation and differentiation 29851 942 958 4261 604 695 613 PMC4997401__F5 Promoter-specific DNA methylation of genes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) mitogen-activated protein kinase (MAPK) signaling pathway 4351 2885 5894 6722 2316 355 1616 4149 4208 929 7189 51295 51701 PMC5002303__F2 Insulin signaling pathway 355 2308 3643 5163 5164 3630 7249 6009 572 2475 2885 PMC5005329__F1 Current view on T cell NNCS in regulation of immune function 920 324 7535 6786 84876 1103 PMC5007661__F3 Potential impact of bone tissue engineering in the clinic 23353 6714 324 2353 581 572 PMC5030232__F7 Major metabolic pathways anticipated to participate in spore germination process in N 2821 25796 5424 132 5226 22934 PMC5031334__F6 Proposed biosynthetic pathway for ATM 1636 5091 49 417 9048 PMC5036175__F6 Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus 11043 2539 5824 5091 PMC5040710__F8 Illustration of role of differentially regulated proteins involved in different pathways in rice for sustaining during drought stress 2597 2739 1431 875 4397 PMC5041887__F6 Cell polarity signaling in the plasticity of cancer cell invasiveness 81839 998 57154 387 23002 5728 324 PMC5053262__F1 UPRmt signal transduction pathway in mammals and worms 59286 8192 10682 1998 PMC5053351__F7 The Pga1-mediated signal transduction pathway, showing the effectors AC and PKA previously reported in different fungi, along with newly identified effectors and proteins and their relation with the cellular processes regulated by Pga1 847 7083 5901 PMC5054600__F7 Working model of lifespan extension induced by impt-1 knockdown in C 55364 4553 10985 22809 PMC5056247__F1 Mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3 kinase (PI3K) pathway with downstream effectors 2885 5728 5163 7249 7248 572 4193 6009 2002 PMC5056854__F5 PPAR signaling pathway upregulated in LCMUFA group compared to control (FDR < 0.01) and olive oil group (FDR < 0.01) 5360 4023 4312 3611 7316 PMC5061784__F3 HER2/PI3K/PTEN/Akt/mTORC pathway and potential sites for intervention with small molecule membrane‐permeable inhibitors and monoclonal antibodies (MoAbs) 2885 3667 5728 5163 7249 7248 2475 6009 64798 253260 64223 8408 6194 PMC5070418__F1 Signaling pathway involving mTORC1 6259 3845 4763 5728 7248 7249 6009 8408 1977 PMC5072731__F7 Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations 4149 8772 4615 51135 7189 958 1513 7187 PMC5074086__F1 Pheochromocytoma: The First Metabolic Endocrine Cancer 1431 47 4191 2271 PMC5078108__F1 PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma 5728 2885 5163 5164 4193 2695 2932 7249 7248 572 581 6009 PMC5081415__F4 KEGG analysis of STRING network of C 339287 4440 100310785 3084 7549 4156 1233 1255 646625 5105 9541 1373 80146 151056 3491 PMC5083753__F3 Anticancer and analgesic activities of B‐caryophyllene (BCP) and B‐caryophyllene oxide (BCPO) 596 2475 6774 PMC5088510__F3 Proteins modified by lysine methylation from the PhosphoSitePlus database were mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) prostate cancer pathway 5728 5163 1017 4193 2885 1499 595 2475 596 6716 367 PMC5098226__F1 Engineering of Escherichia coli for direct and modulated biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer using unrelated carbon sources 3939 717 43 PMC5099458__F1 Canonical and noncanonical Notch signaling pathways 1499 8452 9817 PMC5100792__F1 Isoprenoid biosynthetic pathways and enzymes in Arabidopsis 3652 3422 91734 PMC5101720__F7 Pathway analysis using the KEGG Pathway database 5972 6102 23237 6185 6120 PMC5110973__F4 Nitrogen-induced metabolic changes and molecular determinants of carbon allocation in Dunaliella tertiolecta 2695 5132 4118 4311 5183 4018 65057 PMC5118094__F7 Cocaine regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) 998 6010 2934 1072 10552 10095 10093 10109 10092 2885 1398 6714 1793 1843 1977 2002 4772 4609 6722 PMC5122440__F2 Sweet trap in tumors: aerobic glycolysis and potential targets for therapy 2539 7249 7248 5728 57103 2475 3939 5163 PMC5122717__F7 Model representing the interaction of Arabidopsis thaliana plants/Brevipalpus mites/CiLV-C 2077 4609 27161 PMC5123406__F1 Conceptual model of viral integration 472 545 5888 671 23476 PMC5128915__F2 THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer’s Disease 1017 472 545 637 412 4609 836 4193 64065 7249 5728 881 PMC5131988__F3 Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy 1489 3976 6714 342538 23523 2932 5534 5532 2626 9421 PMC5133177__F1 Mitochondrial Fe–S cluster biogenesis and Isu degradation 9054 5292 2242 PMC5133671__F8 Simplified model for how AhR mediates the RANK/c-Fos signaling axis of osteoclast differentiation and bone resorption 196 4772 4519 4538 4514 4512 PMC5133779__F4 Differentially expressed proteins involved in HIF-1 signal pathway 3569 7099 7428 2056 7037 7018 2271 3162 6513 5163 3417 5106 226 2027 5230 3939 PMC5141361__F3 Details of the PMF network model showing deregulated miRNAs and genes that participates to specific connected pathways, linked in turn to biological processes and functions germane to the disease 23365 126353 5728 51378 2475 4846 405 1387 387 PMC5145803__F1 Redox states of the mitochondrial NAD and NADP pools are determined by a range of interconnected pathways 3417 3418 4190 175 57716 6648 65220 23530 4693 PMC514817__F2 Cytokine production by MAPK pathways 2645 998 2002 6722 3725 PMC514952__F1 Mechanism of endocytic downregulation of RTKs 2060 3092 8411 8027 23163 7251 PMC515190__F1 Cholesterol metabolism showing the physiological compartments involved 19 3931 7038 1071 65057 PMC5158012__F4 Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target 54209 6850 27040 PMC5182003__F2 AKT signaling pathway map 3815 4609 7039 1956 4193 842 960 572 2475 2932 5880 1499 324 PMC5187845__F2 Acceleration of osteoblast differentiation through the p53–Akt–FoxO pathway 3486 5728 4485 1647 1977 PMC5206550__F1 Hypothetical representation of the link between the Hog1 MAPK and the lipid metabolic pathways activated in R 4099 1040 84249 PMC521130__F2 Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts 7054 6141 51083 PMC5226538__F3 ‘melanoma-enriched’ microRNA miR-4731-5p acts as a tumour suppressor 9126 4089 4193 6502 699 5111 1021 1019 1017 1022 4661 999 1869 10926 PMC5243181__F1 Differential gene expression in PPAR signaling pathway 3158 335 5360 4023 4312 7350 3611 7316 364 PMC5256616__F6 Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast 9628 472 581 55332 PMC5264313__F4 Microarray analysis reveals alterations in the expression of major pathways of cellular metabolism in response to changes in collagen extracellular matrix density.A 6470 6472 5723 26227 4190 5163 3091 PMC5276719__F2 Interconnections Between Autophagy and Integrin-Mediated Cell Adhesion 1956 90427 581 6714 55626 PMC5278199__F1 Human EGF signaling pathway (reprinted from Biocarta ) 1950 50964 126669 2885 5894 6774 847 2002 6722 PMC5278230__F7 Proposed mechanism underlying HSYA-SDT-induced autophagy and inflammation inhibition in THP-1 macrophages 6476 2475 9474 PMC5285348__F9 Beijing Mycobacterium tuberculosis (M 50964 9350 147111 387 324 1499 51176 PMC5286800__F4 Summary of DNA damage-induced breast cancer by estrogen and stressors 367 993 4193 472 PMC5287080__F1 Transforming growth factor B (TGFB)-induced activation of the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinase (MAPK) pathway 2885 4087 4088 4089 PMC5294813__F3 Functional network of the interferon signaling pathway by IPA 3458 8651 8554 10379 581 3659 PMC5296245__F2 Restoring sAPPA functions as a potential treatment for Alzheimer’s disease 3481 4035 23621 102 PMC5296320__F2 Schematic representation of the role of pancreastatin (PST) in the regulation of insulin secretion from pancreatic beta cells 5163 2645 2638 57120 4099 PMC5314913__F1 Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases 5728 5163 375 2475 6009 64798 84335 6774 55626 PMC5318911__F7 Identification of miRNA-mRNA Modules in Colorectal Cancer Using Rough Hypercuboid Based Supervised Clustering 324 1499 387569 572 842 6010 836 1630 4089 2956 581 PMC5321522__F1 Clinical imaging of cancer metabolism 57103 2147 355 2744 PMC5325457__F5 Ubc13: the Lys63 ubiquitin chain building machine 958 7187 7189 7186 8717 51135 3654 23118 257397 9025 8772 PMC5328816__F6 A schematic representation of carbon metabolism in wine yeast, including glycolysis, pentose phosphate pathway and tricarboxylic acid (TCA) cycle 6886 2819 2820 5230 2026 100996949 2023 48 4191 50 622 3417 3418 PMC5334259__F2 Cellular unfolded protein response mechanisms 338386 7494 22926 PMC5336598__F1 Role of the unfolded protein response (UPR) in cancer 22926 83939 468 PMC5337177__F2 Mechanisms by which mild mitochondrial uncoupling protects neurons against oxidative stress, excitotoxicity and the accumulation of disease-related self-aggregating proteins such as amyloid Beta-peptide, Tau and Alpha-synuclein 627 90550 6648 23410 2475 23237 2353 7019 7249 PMC533862__F1 Heuristic model showing the tyrosine phosphorylation signaling pathways in sperm cell involved in capacitation 4942 717 26256 PMC5338640__F3 Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration 6714 387 998 PMC5338640__F4 Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration 324 89780 2875 PMC5341220__F2 Canonical signalling pathways activated by the EP receptors 1499 387 1958 PMC5341901__F4 On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer 2064 4609 2744 2271 3418 3091 3417 PMC5343325__F2 MAPK signaling pathway 627 4351 6722 4342 4763 2316 51466 7124 7186 355 1616 4149 929 23118 51295 51701 PMC5343325__F3 P53 signaling pathway 81553 1017 472 545 572 4609 836 7249 5728 PMC5347721__F1 Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex 6714 4088 6736 6908 PMC5352145__F10 Genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel 25873 9184 353 2729 6128 5137 1982 2922 9669 64221 867 PMC5356597__F3 GADD45B, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens 10274 5885 1874 4193 699 9184 5111 993 1022 1017 4661 8318 6502 1869 929 8317 10926 PMC5356911__F1 Extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma 23118 257397 7189 10454 85451 PMC5370034__F6 Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway 581 637 5111 1017 PMC5372671__F1 Mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway 5728 64798 23191 1977 7248 7249 7337 4763 6009 4204 PMC5382464__F1 Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the FoxO signalling pathway (KEGG ecb04068) 4089 4088 6502 51701 4193 664 9140 5728 3630 3643 472 7874 1017 6774 3575 1956 1950 6494 PMC5382464__F2 Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the PI3K-Akt signalling pathway (KEGG ecb04151) 2475 1977 6009 7249 5879 613 6850 930 11140 5934 5728 572 150365 5266 6256 4193 PMC5384023__F7 tmTNF-Alpha-induced STAT1-dependent apoptotic signaling via TNFR1 6772 8717 8772 7186 PMC5386953__F2 Signaling Pathways Controlling Microglia Chemotaxis 948 6714 7408 PMC5394831__F3 GnRH signaling pathway containing PLCB1 and MAP2K6 1610 998 4313 5894 PMC5397509__F1 Central role of RTA in reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV) from latency leading to lytic cycle 2113 6741 6774 3661 5371 23462 6670 5300 4781 PMC5400663__F1 Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas 2475 4090 4086 1950 1956 PMC5412052__F5 Combined gene expression and predicted activation information for the mTOR pathway in the heart and small intestine 5091 7248 7249 1977 9776 1999 6010 1975 3921 3643 5163 6009 4553 5894 5728 6720 6721 PMC5419474__F10 NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans 6010 7204 57578 PMC5419541__F3 Signaling Pathways for Permitting Cross Talk between WNT and GnRHThe shaded pathway represents the skeletal features of the canonical Wnt/Beta-catenin signal transduction pathway 6714 998 324 2932 1499 3725 PMC5423041__F1 Molecular mechanisms involved in macrophage inflammatory protein-2 secretion of macrophages 7099 6774 9021 PMC5428490__F2 Transcriptome pattern differs between two oil biosynthesis tissues in oil palm 2821 2597 84706 5538 355 8694 5091 4018 PMC5429338__F2 Main potential molecular mechanism of the antitumour effect of anthocyanins in vitro 4313 4318 1950 6714 6774 5111 PMC5430701__F1 Chemokine signalling pathway (source-http://www.kegg.jp/kegg/kegg1.html) 2885 126669 1794 3702 387 1610 PMC5431011__F7 Glycerophospholipid metabolism is induced in parasitized A 95 1431 7038 57678 4023 1040 9489 56894 9926 30814 5091 PMC5445305__F7 Characterization of central metabolic model in developing L 27130 25796 2597 2821 2695 6120 2027 5132 5183 4118 5091 4018 PMC5446554__F1 Highly simplified overview of various functions of the mitochondrion, adjusted to highlight the steps catalyzed by enzymes for which the respective encoding genes were studied in this work 2653 5162 1329 4967 PMC5448101__F8 Ubiquitin editing in the Imd-signaling pathway 1611 23118 8772 PMC545204__F3 Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia 5371 5914 2322 4512 PMC5455213__F1 Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature 4841 961 27035 PMC5457689__F6 Apoptosis pathway 1616 790 468 637 27429 79068 PMC545911__F1 Phosphoinositide kinase specific genetic interactions 375 400 738 90196 27072 PMC5470118__F3 Canonical cannabinoid receptor (CBR)-mediated, G protein-dependent signaling pathways 2475 6714 6774 PMC5472375__F4 Based on GeneCodis3 analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, 23 significantly enriched pathways were revealed 3630 358 8796 1811 1956 2002 2885 7186 23118 7189 6401 6722 PMC5477485__F2 Conserved insulin-signaling pathway in the ovary 3480 3667 8660 9798 8471 5163 207 208 PMC5477576__F4 Intrinsic apoptosis pathway 572 637 581 83939 7186 PMC5479833__F4 Current model for selective compound families to promote neuronal compensation in HD via a stress response system centered onto FOXO and its co-factors 2932 207 10062 1499 23411 10940 6649 7166 150365 3792 2203 5008 23190 983 1024 3716 6658 10769 PMC5484492__F4 microRNAs in cancer 324 5728 355 80896 847 4609 6659 960 472 PMC5485291__F2 MTOR signaling pathway and the possibility of curcumin's pharmacological action on the pathway in the treatment of SCI 5728 2475 7249 253260 64223 6009 1977 9776 PMC5487892__F3 DNA substrates and protein factors required for S-phase checkpoint activation 1763 54465 5111 8318 4360 5426 5884 PMC5487993__F9 Paraquat hijacks the pentose phosphate pathway to induce oxidative stress and cell death 2539 5226 2821 7086 2597 5230 2805 1431 2744 4967 PMC5492466__F3 Transcriptional changes of genes involved in basic metabolism in Bgt during asexual development on Chancellor 7504 2821 7086 51117 1431 4397 PMC5494096__F4 Pipeline of cell cycle and MAPK signaling pathway 9126 4087 4193 6502 4609 324 991 5111 1017 1022 8318 4661 990 999 8317 10926 4998 4999 23595 5000 23594 25805 4089 3458 8454 1616 387 5308 4838 PMC5494993__F6 Discovery of extremely halophilic, methyl-reducing euryarchaea provides insights into the evolutionary origin of methanogenesis 914 22934 132 5447 4519 2241 5624 2242 PMC5496883__F3 Signalling by Rho GTPases (upper panel) and Neuronal system pathway (bottom panel) 177 5880 998 56479 10060 3763 PMC5499174__F1 The assayed components of the IIS/TOR pathway and their proposed interactions in D 5728 5163 207 23235 7248 6009 4609 PMC5500762__F3 Lysine acetylation events involved in carbon fixation (A), tricarboxylic acid cycle (B), and photosynthetic pathway (C) 5162 7086 22934 443 6389 6390 4519 2242 4335 1431 PMC5500790__F1 Wnt signaling pathways 324 6010 6259 PMC5501134__F5 Complex and context dependent functions of the Slit/Robo signaling in angiogenesis 9353 6091 54538 6010 382 5879 6714 PMC5501684__F5 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection 3466 920 1356 7054 3606 962 3565 55744 PMC5504455__F10 Diagrammatic summary of the principal ways by which the Unfolded Protein Response pathway may interact with the mTOR/AKT pathway to modulate protein synthesis within the placenta 2475 83939 1977 1938 22937 PMC5508010__F4 Quiescent (A) and activated (B) metabolism in differentiated mammalian cells 2147 6120 11113 4118 3815 3418 4967 PMC5508010__F5 To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection 57103 4609 5728 PMC5508527__F2 Metabolic reprogramming and tolerance during sepsis-induced AKI 23411 51548 7124 PMC5515442__F8 Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells 7249 4087 2475 4088 999 6120 PMC5517784__F5 Figure illustrating cumulative flux index in glycolysis, TCA cycle and electron transport chain in glucose metabolic pathway 2821 2597 3033 1431 4191 2271 4967 PMC5519011__F3 redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models 2752 1896 7851 4118 4199 4200 84890 759 1431 11113 PMC5520491__F1 Classical and new Wnt/Beta-catenin pathway canonical and non-canonical pathways 324 6497 6010 3725 6259 PMC5524058__F8 Mechanisms of halofuginone action 4553 83939 468 PMC5527897__F2 N‐linked glycosylation 79868 56052 10195 84920 79053 29929 23443 4247 4248 PMC5528296__F2 PI3K signalling regulates both choline and glucose metabolism 57103 5728 5130 4609 2475 PMC5528412__F1 Simplified representation of the PI3K signaling pathway 5266 5728 8821 5163 7249 6009 PMC5531310__F2 Arginine metabolism is increased in the idiopathic pulmonary fibrosis (IPF) lung 383 384 4942 PMC5535966__F8 G-protein signaling of LW pigs 156 695 1445 5091 2002 PMC5536940__F1 Transduction of platinum-induced DNA damage: DNA repair or apoptosis 472 672 675 79728 PMC5541893__F3 Mechanisms involved in initiation, perpetuation, and resolution of inflammatory responses 2358 367 301 7054 4353 6279 PMC5543471__F8 Molecular mechanism of the mTOR pathway in Vil‐Cre;Pkd2 f3/f3 mice, with or without rapamycin treatment 1017 8178 983 PMC5544253__F4 BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure 6649 10763 7040 10149 1238 8707 26227 7169 581 9516 4925 1051 3725 5970 PMC5545609__F4 Diabetic endothelial cell metabolismIn diabetic ECs, hyperglycemia increases production of ROS through a variety of intracellular sources, including NADPH oxidase, xanthine oxidase, uncoupled eNOS, and impaired pentose phosphate pathway (PPP) 367 2539 5209 2147 2152 142 2597 PMC5551366__F12 Mitogen-activated protein kinase signaling pathway 6722 4342 4763 2316 7124 1616 4149 929 23118 51295 51701 PMC5553399__F8 Proposed mechanism for G2 phase-specific nuclear export of CENP-F 1063 55746 983 PMC5555084__F1 Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors 3098 2597 3939 5163 PMC5558548__F5 Sphingolipids as targets for treatment of fungal infections 3791 5091 7054 6611 64781 9350 4284 PMC5562963__F1 Early and lethal neurodegeneration with myasthenic and myopathic features 4351 5373 29925 9526 8813 8818 54344 22845 56052 79868 1798 29880 57171 91869 29929 84920 PMC5564849__F5 Integration of phytochemicals and phytotherapy into cancer precision medicine 115908 4356 3416 28978 6500 10147 4692 285367 2976 84154 7644 6596 678 84928 10491 23784 1370 3397 5925 55167 126669 26015 22913 367 25957 27434 2077 60528 1738 PMC5572303__F5 Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins 1950 2335 2149 55970 28964 1398 2316 1793 5829 10152 7414 2934 PMC5576431__F3 Downregulation of the neurotrophin-MAPK signaling pathway in DPN 10818 1398 4803 2549 572 PMC5580204__F4 Signalling pathway in normal and hyperglycemia patients 6098 4318 1017 7852 PMC5584303__F2 Epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer 1869 79733 6667 2305 7528 29128 7874 PMC5585627__F3 Sphingosine-1-phosphate (S1P) in estrogen receptor- (ER-) positive breast cancer 1950 1956 4363 9429 8877 2475 PMC5587377__F2 Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a “Watch-and-Wait” Approach to Cancer 387 7408 3611 5728 573 126669 572 PMC5587604__F5 Hydroquinone suppresses IFNB expression by targeting AKT/IRF3 pathway 4615 3661 3553 PMC5591914__F1 5-HT biosynthesis and metabolism in peripheral tissues 121278 7166 5091 PMC5592666__F2 CoQ6biosynthetic pathway in S 51004 91949 51805 27235 10229 PMC5596340__F5 Metabolic reconstruction of the candidate phylum members PAUC34f, Parcubacteria (OD1), Peregrinibacteria, and ACD39 (Bin 13) 367 3249 126669 7054 PMC5613237__F4 Galactose metabolism pathway 3486 1017 427 324 2932 1499 4088 PMC5618564__F2 FAK-deleted keratinocytes demonstrate alterations in key mechanotransduction and collagen signaling pathways 4312 2821 493829 PMC5624455__F4 Leukocyte extravasation signaling pathway altered by a high-fat-diet, Taeumjowitang, and green tea in the epididymal white adipose tissue 387 10125 920 960 399 3676 3683 3689 7408 58494 3688 2241 5829 1398 2017 7054 PMC5627515__F3 Protein-bound uremic toxins could take use of five potential toxin-conjugated albumin-receptor pathways to either promote or suppress inflammation 6678 387 998 6714 PMC5628484__F6 Regulatory roles of differentially expressed genes involved in the MAPK signaling pathway (a, map04010) and pathways in cancer (b, map05200) 4351 1956 2885 5894 4342 2316 3727 2002 7124 7186 355 1616 8544 4149 23118 7189 51295 5426 PMC5629314__F6 Abbreviated pathway of prenol and sterol lipid synthesis in C 27235 51004 84274 51117 51805 4553 PMC5638116__F3 Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer 1956 1950 998 10928 4609 3297 4193 2475 PMC5643752__F1 Schematic representation of Nrf2 and Keap1 protein domains 9817 4094 8452 PMC5650366__F8 Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model 581 1998 22926 7186 7466 468 9776 22863 9140 10533 83734 64422 PMC5654107__F5 Model of metabolic processes upregulated in aerial and in root cells 55276 64434 3280 2203 5105 50 127 48 3418 383 7067 1356 7018 PMC5657612__F10 The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease 4035 948 8301 361 PMC5660707__F2 Model describing the copper transport system and its association with AD 538 540 9973 10063 475 2932 PMC5661624__F3 Redox regulation of cell–cell junctions 7939 5970 6935 PMC5667558__F1 microRNAs and lipid metabolism 5205 5562 8854 19 3916 3988 9474 10533 9140 9619 3931 PMC5675827__F7 Ingenuity Pathway Analysis (IPA) comparisons of the quantified readouts from 56616 27429 8797 8772 79002 5884 3163 6714 3329 PMC5677515__F3 Significantly Mutated Genes and Regulatory Pathways in SCLC – A Meta-analysis 387 2534 4750 27240 6092 6091 64221 29984 2242 6237 5810 8482 5727 3611 6469 6608 91653 6259 PMC5688007__F2 Mitochondrion: a central architect of copper homeostasis 538 6647 90639 6341 23410 2936 PMC5700458__F1 The UPR mediators have versatile roles in different cell types either in the presence of balanced or unresolved ER stress 7494 100187761 6774 PMC5700962__F10 Thyroid hormones pathway (red, up-regulated) 6714 6955 2626 3091 4193 6009 5208 572 5214 PMC5700962__F11 Apoptosis pathway(red, up-regulated) 8772 1616 8717 790 9049 835 637 472 581 572 8739 4803 PMC5700962__F12 Cell cycle pathway(red, up-regulated) 9126 4089 4193 6502 9184 699 991 5111 1022 1017 4661 6351 1869 1874 924 10926 PMC5700962__F7 Six genes are enriched in the top 2 significant pathways(red, up-regulated) 10097 3977 3815 4050 650 3952 3953 183 2056 1896 10913 5617 7173 PMC5700962__F8 Parkinson disease pathway(red, up-regulated) 6622 7054 64326 27429 2147 PMC5700962__F9 Breast cancer pathway(red, up-regulated) 5728 126669 1956 1019 3815 100188776 324 PMC5701508__F1 The crossroads of breast cancer progression: insights into the modulation of major signaling pathways 1956 2444 108348016 5970 6667 1839 2852 857 PMC5702396__F1 Apoptotic Pathways in Glioblastoma 4193 581 5728 5163 PMC5704542__F8 Model for regulation of nitrogen availability response 9776 1975 6194 PMC5705340__F2 KEGG Ras signaling pathway with targetable nodes highlighted in red 64434 572 1610 27040 PMC5706558__F8 Summation of the proteomic values for the ERBB2− sample set for genes present in the regulation of actin cytoskeleton pathway for ERBB2− set from KEGG 2147 3630 1379 1793 324 6010 5829 7414 2934 PMC5710802__F3 RLR-mediated RNA sensing pathways 23586 57506 8772 8717 10010 3665 3586 3569 PMC5714444__F2 The role of the HBP and protein O-linked GlcNAc conjugation in the regulation of Drosophila physiology 8473 10724 5238 6675 PMC5724014__F6 Mechanisms of cytokine-induced dysfunction and death of insulin-secreting cells mediated by intracellular S1P 572 11331 3458 PMC5727169__F5 Pathway analysis using WikiPathways revealed that the factors related to the calcium signalling pathway (Kelder, T., Chichester, C., Hanspers, K.: Calcium Regulation in the Cardiac Cell (Danio rerio) 5996 5999 154 6693 7533 7534 7532 11142 PMC5730419__F2 Alternative signaling pathways of GFLs 6714 126669 2549 2885 5979 2619 PMC5732027__F5 Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements 192669 27161 11201 PMC5733868__F4 Path diagram of the nuclear factor kappa B (NFKB) signalling pathway 3558 3565 1950 4803 4049 920 5971 5970 5966 PMC5738336__F9 KEGG (Kanehisa & Goto, 2000) PI3K-Akt signaling pathway (map04151) is enriched for genes differentially expressed between lesion and healthy lung tissue in cattle challenged with BRDC pathogens 2475 10682 1975 7249 5879 613 6850 930 5934 5728 572 4199 6256 4193 PMC5739091__F1 Rag GTPase-dependent amino acid signaling pathway upstream of mTORC1 652968 729438 6009 153129 PMC5739549__F1 Mechanisms leading to transitory or sustained PD-1 expression in activated and exhausted T cells 324 367 352963 940 201633 PMC5741957__F3 Oxidative phosphorelation metabolic pathway 4519 11316 4536 4538 4537 4541 4722 4731 4720 4724 126328 4705 6389 6390 6391 6392 6476 1352 10063 1353 PMC5748990__F2 Pathways regulating senescence-mediated arrest 4193 1021 1019 PMC5750119__F9 Transcripts corresponding to most genes present in the KEGG Cell Cycle Pathway were increased in abundance in CCDs from rats on Day 2 of development of vasopressin-escape 4087 4088 4118 9184 1022 6502 4661 23632 7851 PMC5751331__F1 Lysophospholipid-mediated PPARG signaling 5091 4018 5338 6098 PMC5751802__F3 Signaling pathways corresponding to Tables  and 991 999 472 4193 PMC5752491__F3 Integrated analysis of chromosome copy number variation and gene expression in cervical carcinoma 545 472 699 9184 4089 6502 324 5111 1017 1022 8318 4661 3630 4998 23595 5000 991 990 8317 23594 4999 PMC5758508__F8 Rationale for the problematic role of B2 adrenergic agonists in clinical trials 1080 156 5091 1499 PMC5760356__F1 Kegg PI3K/Akt‐Signaling pathway with highlighted dysregulated mRNA and their associated seed‐region matched miRNA 2475 10682 10752 5879 10020 613 6850 5934 5728 572 1637 8190 PMC5762524__F3 Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus 4351 1956 2885 6722 4342 2316 3725 1386 7186 355 4208 929 23118 7189 51295 51701 PMC5774508__F6 DEGs enriched KEGG map of the TNF signaling pathway in myocardial infarction 7124 8772 847 83737 355 3600 7186 6401 PMC5776165__F1 MAPK signaling pathway, where each MAPK phosphorylates several transcriptional factors, regulating protein expression 203 4609 1386 4208 4209 4205 2002 PMC5779965__F5 Confirmation of some miRNA and target gene expression and integrative pathway analysis 2335 126669 1019 2200 PMC5780146__F6 Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the influenza A pathway 57762 3569 3661 114034 9021 103 10379 5371 3458 51596 842 PMC5786286__F5 5-HT2Asignaling pathways 6714 2885 331 6722 596 581 PMC5789953__F1 Lipoic acid synthesis and scavenging in E 3988 3989 340654 149998 PMC5791813__F1 Interplay between Nrf2 and Brf2 pathways 9817 8452 4553 PMC5797605__F2 mTORC1 and mTORC2 complexes 2475 717 64798 7249 7248 6009 5465 PMC5798144__F6 Egulation of actin cytoskeleton pathway and the differentially expressed genes on the bare and the TiN-coated NiTi alloys 3630 2147 51083 1793 998 324 6010 10152 5829 7414 PMC5803081__F1 Beyond Alkylating Agents for Gliomas: Quo Vadimus? 3099 4609 3417 PMC5803173__F4 RBM20 structure and potential TTN splicing mechanism(s) regulated by RBM20 282996 6240 5163 PMC5803300__F8 ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway 627 29123 1786 4204 PMC5805379__F3 Renaissance of complement therapeutics 1378 1380 1356 720 PMC5813531__F3 Retrograde signaling during photooxidative stress in chloroplasts 5595 5597 5091 PMC5818890__F4 Common highly linked molecules and their most significantly related signaling pathways and functions in the “matrine-CRC” merged network 2580 3146 3458 7124 7099 613 6010 4436 4609 7157 1356 100271694 6714 5728 5901 759 2875 1387 5395 PMC5819363__F1 Genomic Landscape of Pheochromocytoma and Paraganglioma 2271 4191 7428 7812 1499 4609 6608 6009 7249 7248 55654 546 5979 4804 4763 4149 PMC5819904__F1 Core components of the Hippo pathway 4018 4485 6010 7003 8463 7004 7005 PMC5819904__F5 Regulation amongst the Wnt/Beta-catenin, LPA and TGFB/Smad signaling pathways and YAP/TAZ of the Hippo pathway 4018 1950 9113 4485 324 6010 847 PMC5819906__F6 Differentially expressed miRNA gene targets in the insulin signaling pathway 355 2308 3643 3630 7249 6009 572 2475 1977 PMC5821264__F1 Regulation of Signal Transduction by DJ-1 367 2932 2475 4318 4313 PMC5822899__F2 Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue 7412 3569 114034 958 6256 3458 PMC5827745__F2 BCR‐ABL pathway 4087 6608 5728 4089 1499 3549 3717 613 2309 2475 2885 PMC5831670__F4 Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer’s Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses 3569 4282 3146 PMC5831804__F1 Major players implicated in the phenotypes associated with the deletion of GUP1 in S 6094 6493 998 5004 5005 84188 11043 PMC5832583__F5a Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism 1431 50 4191 3418 2271 PMC5837599__F3 Typical structure and content of exosomes 967 975 928 PMC5838471__F1 Metabolic pathway of AB and GPCRs in Alzheimer's disease 351 2827 3579 1103 1020 572 2931 PMC5840040__F3 Thermodynamic description of the eIF2B catalytic cycle 1998 4827 1997 10209 2695 PMC5842023__F8 T cell receptor signaling pathways in eosinophilic asthma 3932 962 867 2534 27040 3702 1019 8915 914 2885 7535 1610 940 PMC5852471__F8 Cell cycle arrest and apoptosis induced by BOS-102 in A549 cells 595 581 1019 PMC5852605__F1 Canonical and non-canonical Wnt pathways and their effects in pluripotent stem cells (PSCs) 324 6010 1386 PMC5854367__F1 Most of Theileria parva proteins involved in glycolysis and tricarboxylic acid cycles were identified in this study 2821 2597 4967 5230 5236 5183 2271 5091 PMC5854419__F1 Mitogen-activated protein kinase signaling in plant pathogenic fungi 11043 10487 7536 PMC5864536__F1 Estradiol and the Control of Feeding Behavior 4922 7200 1392 4852 181 5443 885 PMC5864870__F1 Anti-gliomagenic effects of different psychiatric and non-psychiatric drugs as demonstrated via in vitro studies 1956 4255 596 3725 2475 9900 5347 PMC5865879__F1 Chemokine signaling pathway significantly enriched in differentially expressed genes 3717 126669 57580 1794 399 1398 PMC5866357__F3 General overview of metabolic pathways in healthy ECs 6652 2539 2147 2597 2194 355 1374 3418 2744 435 5209 PMC5867015__F2 Signalling pathway of Pak1 in the heart 998 5879 5058 5350 4088 114907 6722 PMC5868594__F2 MicroRNAs in the nuclear factor kappa B signaling pathways 8717 4615 7186 7187 7188 5971 PMC5869511__F1 Antiviral innate immune pathways in dipteran insects 3550 27161 54464 4615 PMC5872179__F2 Proximal T-cell signaling cascade 940 920 3932 5163 5697 7535 7409 2353 4609 5966 3725 102724566 PMC5872357__F1 Epac signalosome in cardiac hypertrophy and ischemia 2691 2692 9759 3418 6262 PMC5878997__F3 Extranuclear Signaling by Sex Steroid Receptors and Clinical Implications in Breast Cancer 6714 2885 1950 1848 1017 7018 1956 6667 3045 100187828 PMC5882306__F4 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells 2885 867 6714 2922 85451 572 472 4609 581 4149 54205 5933 637 51701 51684 8772 23385 914 1610 1398 545 286204 59330 2157 28996 3725 27148 7038 PMC5882534__F2 Optogenetically controlled protein kinases for regulation of cellular signaling 5163 581 572 2002 PMC5889750__F5 Platyfish significantly down modulate the IGF signaling pathway leading to a suppression of cell proliferation, cell growth and cell survival in skin following FL exposure 3479 2885 5829 4734 2887 3716 5163 572 6774 PMC5889750__F9 Platyfish skin (A) significantly down modulates the PPARA/RXRA signaling pathway in response to FL; however, both medaka (B) and zebrafish (C) significantly up-modulate the PPARA/RXRA pathway in skin following FL exposure 7189 8431 3725 PMC5893262__F3 TCR complex activation 27040 2885 7124 2353 PMC5893285__F2 miR-126 is involved in neurotrophin signaling pathway pathways including IRS1, PI3K and IKB, which their partial diagram collected from KEGG pathway is demonstrated 4703 759 572 1610 8480 7189 2242 3667 PMC5893285__F3 Involvement of miR-126 targetome in focal adhesion signaling pathway from KEGG is shown 5728 2534 126669 2002 572 3725 PMC5900450__F2 Arachidonic acid (AA) pathway of inflammation mediators 4512 4015 4513 4049 978 5226 PMC5900771__F1 Methylation and glycerolipid metabolism in yeast 84890 355 5091 7038 PMC5901872__F2 Expression difference of metabolic genes between the GX stage and X stage in BSGX001 and XH7 50 127 1352 10063 9377 PMC5904546__F5 Comparative analysis of differentially expressed proteomic and differentially regulated metabolomic data 2180 51703 10449 1632 95 3030 3032 3028 100187761 PMC5904546__F6 Cardiomyocytes and fructolytic pathway are strongly affected in P7 hearts 3098 3099 5208 226 230 7038 PMC5906968__F1 Schematic representation of the regulatory pathways affecting gene expression during mouse spermatogenesis 8852 5619 367 PMC5907526__F8 Overview of the TLR4 signalling pathway 100187907 7189 3661 3553 PMC5910405__F1 Our multi-omics integrative analysis of the monolignol biosynthetic pathway in P 729230 7054 7808 29954 PMC5913738__F2 Intermittent metabolic switching, neuroplasticity and brain health 627 23410 4899 7019 6648 3418 2475 8408 PMC5916931__F4 Dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression? 947 4513 2642 2638 PMC5919962__F1 Platelet targeted therapeutics 6714 4512 6010 7450 2811 4067 10284 23440 10519 759 5340 7448 7018 PMC5922990__F6 Naringenin prevents acute and chronic CCl4-induced liver damage 4092 8772 4088 581 9817 4089 847 4094 PMC5922990__F7 Naringenin in cancer development 4318 1956 2885 3550 1017 2353 596 3725 847 1950 PMC5926825__F1 Reactive Oxygen Species in Metabolic and Inflammatory Signaling 6786 472 3091 5163 7249 2475 PMC5927721__F1 MiRNAs targeting the IGF1R pathway in its entirety 100033819 693186 2885 693219 126669 7249 7248 2308 406921 554213 572 2932 406991 619556 406928 PMC5928575__F2 Ovulatory cascade 4512 2069 374 7130 3037 PMC5929146__F1 Metabolomics Applied to Islet Nutrient Sensing Mechanisms 5091 23152 3417 PMC5930454__F8 miR-135b upregulated in BLBC represses multiple genes 25805 4089 8480 3458 4091 4092 9978 6500 4052 4087 4088 1874 7046 387 10468 4838 51701 147111 324 50964 8454 23002 9475 27130 PMC5932588__F1 Molecular mechanisms that connect cellular junctions to the Hippo pathway 154796 92359 64398 10207 4485 55233 790 8994 7791 PMC5937716__F3 Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration 411 51102 50632 6890 1431 11337 1174 847 6272 8989 50964 10 3952 7011 27159 9118 6770 3953 6295 5901 PMC5938282__F5 Unique genetic cassettes in a Thermoanaerobacterium contribute to simultaneous conversion of cellulose and monosugars into butanol 5805 2821 2539 64131 2597 2026 2023 3045 100187828 PMC5941175__F4 Kinetic reaction schemes of GroEL–GroES interaction revealed by HS-AFM imaging under different substrate conditions 6476 2271 404713 2091 PMC5943908__F6 Summary of the vasoconstriction signal transduction pathways showing points of intervention by Xyl-B 4512 9942 5226 PMC5945837__F8 Galactose metabolism pathway in Streptococcus pneumoniae D39 51083 130589 6908 PMC5949531__F2 Nerve growth factor (NGF) signaling cascade 1398 387 4803 7189 126669 PMC5949932__F2 Regulating network of exosomal proteins and ncRNAs in tumors 100124700 58494 6279 6280 27 283120 3918 999 4602 367 4318 PMC5954032__F1 PI3K/AKT/mTOR/S6K pathway plays a major role in the control of immune cell homeostasis 940 1493 29851 930 5728 847 5163 1975 6009 64798 PMC5954114__F2 GAS6/TAM signaling pathway 2621 8205 2885 PMC5954621__F5 Bile acid regulation of bile acid synthesis 2264 1593 1581 9420 1582 PMC5954861__F3 TBP-2 snd p38 MAPK-NFKB signaling pathway 5447 6285 6908 4513 10133 PMC5954861__F6 TBP-2 regulates autophagy and apoptosis of HLECs under oxidative stress 6908 581 836 2475 PMC5955117__F1 P53 regulates critical points in cell signaling and metabolism 57103 7249 26227 4193 3240 2184 9997 27165 PMC5955428__F2 Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk 627 4351 1950 2885 4342 100422871 PMC5959770__F2 Perspectives on Glycosylation and its Congenital Disorders 22845 1650 23193 65260 PMC5960455__F1 Role of WNT/beta-catenin signaling in gliomas 4040 4041 324 6774 1499 595 3939 PMC5963346__F3 DEGs associated with TNF signaling pathway at different time points after cerebral ischemia 7124 836 4099 197259 PMC5974435__F1 MTOR signaling to the translational machinery 5728 2885 64798 4763 5163 6446 7249 7248 51256 6009 4553 84232 153129 6194 29904 1938 1975 27250 PMC5974435__F3 MAPK signaling to the translational machinery 369 673 8788 7249 29904 1975 27250 64798 6194 351 PMC5977125__F1 Overview of the cap-dependent translation initiation 1999 2001 1983 1997 10209 1998 2475 1977 PMC5984668__F1 STATus of STAT3 in Psoriatic Arthritis 1233 1235 6774 7124 196 2826 PMC5987629__F1 Schematic diagram of the heterologous synthesis pathway for the production of geranyl acetate in the engineered S 3652 3422 84232 4553 PMC5993950__F2 DYSREGULATION OF mRNA TRANSLATION AND ENERGY METABOLISM IN CANCER 5728 5163 6009 1998 1977 6194 1975 1938 PMC5994511__F2 Summary of the speculative roles of UNC5C in AD pathogenesis 8633 1612 331 PMC5997503__F5 PLATELET LIFELINE TO CANCER: CHALLENGES AND OPPORTUNITIES 7018 4512 7448 PMC5997832__F1 IRE1A structure and its downstream mechanisms in mild and severe stress 7494 596 581 637 10628 51493 PMC6003838__F2 The spatio-temporal cell dynamics of the G-protein/Pth11 and cAMP-signaling pathway during surface sensing and appressorium morphogenesis 5996 11223 3349 PMC6004395__F3 ABA-dependent signaling pathway in response to temperature stress 54861 4609 4602 2077 PMC6006682__F4 Representative coverage of Calvin-Benson cycle enzyme 2203 2597 5230 PMC6008457__F1 Reaction scheme of the metabolic sub-model 2695 4015 51083 4099 4018 10750 4118 100187761 3630 367 PMC6025041__F3 HBP modulates cancer metabolism through the O-GlcNAcylation 2539 2597 5315 4976 2194 PMC6027339__F1 Oncogenic MyD88 mutations activate the canonical NFKB pathway 51135 3654 7189 10454 23118 PMC6029073__F7 Examples of well-characterized signaling pathways contain numerous predicted short linear motifs 2937 324 1499 11043 4040 4041 PMC6034857__F10 Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) 2475 1977 10682 6009 7249 613 6850 930 5934 5728 572 150365 6256 4193 7248 1975 3667 1191 4199 PMC6034857__F11 MAPK signaling pathway 4351 2885 5894 6722 4342 2316 3725 1386 7124 7186 355 1616 929 23118 1950 51295 PMC6036173__F2 Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage 1956 6714 2885 3845 3265 998 1311 1019 2475 2002 6722 7099 PMC6036858__F1 Yeast cell cycle pathway from the KEGG database 699 991 717 1201 150094 4118 1039 324 4998 4999 23595 53366 4163 130106 10276 PMC6036858__F2 Gene network of the yeast data related to the cell cycle pathway via the JMCCM 1201 4173 23595 4176 4172 10297 991 10926 4175 4174 PMC6037111__F2 Consequences of hepatic fructose metabolism 47 355 4018 PMC6039108__F3 Hematopoietic Stem Cell Gene Therapy –Progress and Lessons Learned 142 9156 5888 7515 5426 79728 672 3980 675 PMC6042401__F8 Alterations in CREB signaling 2885 6908 27343 11201 PMC6044425__F2 The N-linked protein glycosylation pathway 2673 79868 1798 22845 8818 8813 54344 29880 56052 10195 29929 84920 PMC6047437__F1 Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma 1956 100187761 5728 673 2475 145270 PMC6047913__F6 Enriched target genes of the TFs TCF7, RUNX1, STAT3, and SOX4 in the MAPK signaling pathway 1610 4351 4342 2316 3725 1616 8195 929 23118 51295 4352 4763 355 PMC6050436__F5 MapMan overview of general metabolism for the metabolites and proteins/transcripts of Quercus ilex 2695 11113 115209 8039 PMC6052012__F4 Metabolic construction of the putative pathway for AOM coupled to Fe(III) reduction in “M 4519 4548 717 PMC6054847__F3 Effect on eukaryotic translation initiation factors (EIF2) signaling pathway in plasma of total mRNAs obtained from D-tocotrienol treatment of hepatitis C patients 2885 83939 100187761 1997 10209 468 PMC6061795__F8 An Orc1-2-centered network of DNA damage response in S 4998 4999 4361 10111 23595 5001 23594 5000 6908 PMC6068465__F5 p53 signaling pathway 472 545 355 637 1869 4609 581 94005 836 64065 7249 5728 4193 6477 PMC6070710__F8 Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response 51053 55388 7316 5426 23595 PMC6071544__F16 Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox SignalingReviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward 717 2271 7054 4118 1431 3418 11113 355 3417 7408 PMC6071762__F5 Apparent unidirectional fluxes of the LTP-mediated inter-organelle transport of lipids are indirectly coupled with metabolic reactions of lipids 5007 5091 58488 PMC6072839__F2 Molecular signalling of TRAIL 8772 8737 7186 PMC6073671__F1 Silver nanoparticles on the cell stress response pathways 596 5728 468 7494 847 22926 PMC6073722__F3 APC activity is decreased under nutrient conditions, and increased when nutrients are limiting 996 8881 55140 6502 8697 325 997 22933 324 999 PMC6082538__F4 Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms 248 51083 161823 1636 48 2592 PMC6082538__F6 Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms 729 2819 9615 23481 1889 7150 27240 3092 PMC6084457__F1 Metabolic pathways contributing to HSC self-renewal and differentiation 3939 95 114971 586 1376 3417 3418 5212 4609 PMC6090045__F1 Simplified general overview of glucose, fatty acid, and amino acid metabolism in healthy endothelial cells 355 2539 5209 2147 440 PMC6092260__F2 MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development 10817 10818 2885 2549 9846 3667 8660 2886 2888 2887 6461 1399 1398 6010 998 4133 581 596 4609 2353 5163 PMC6097464__F8 TGF-beta adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2404 set 4117 4351 6655 1386 355 5728 2318 3921 9748 1854 PMC6097464__F10 MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set 1399 399 2318 3611 5728 399694 7422 54623 126669 572 1398 2241 5813 PMC6103261__F1 Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays 5091 4512 4050 4049 PMC6103459__F1 Cell cycle proteins mediating progression during MI 699 9184 4163 324 10403 57405 147841 151246 157570 27127 PMC6103739__F7 Schematic diagrams of SOS1 activation 1956 2885 2695 PMC6104135__F3 Schematic summary of HIF-1 signaling in hypoxia and diabetes 5465 3091 3939 5163 PMC6104565__F5 Pharmacological targets of ErbB2 signaling pathway in Her2-enriched subtype 1950 867 367 1398 685 3725 1839 4609 126669 2885 9542 2475 572 10718 145957 PMC6106831__F5 Granulocyte activation and diapedesis mediators show greater induction during diestrus phase infection than in estrus 2734 3688 3579 4284 7852 3384 83700 1233 PMC6110855__F1 Phenotype change of microglia in neurodegenerative disorders 383 9332 10011 3553 PMC6115711__F3 SUMOylation system and TGFB signaling interplay 6608 64750 10401 8554 4089 999 9839 PMC6115922__F1 Honey Bee Immune Pathways—Highlighting Genes Implicated in Antiviral Immune Responses 8772 23118 285175 27161 PMC6117622__F4 MAPK signaling pathway 1610 3925 4351 1956 1950 2885 6722 2316 3725 7186 2645 355 1616 4149 929 23118 7189 8314 627 51701 7975 PMC6118308__F1 Progression and environmental sensitivity of C 4860 2009 3215 1950 1956 2885 3643 5728 1499 PMC6121189__F6 Prolactin-driven signaling pathways via the short or long prolactin receptors 3717 5617 2885 595 PMC6128439__F6 mTOR pathway 2475 3643 6247 5163 7248 5091 57521 6009 1975 1977 9776 8408 6194 1999 PMC6128898__F9 Expression patterns of T 3652 2222 6713 PMC6131304__F3 PCV2-induced apoptosis 355 83939 468 1386 PMC6131595__F5 Metabolic reprogramming in cancer cells 57103 857 5209 PMC6132177__F1 Autophagy pathway 8408 9706 7405 2475 10533 9776 5624 PMC6139685__F16 Tentative Model Explaining Redirection of Metabolism in the Absence of MDH2 during Photoautotrophic N Deprivation.FA degradation starts with hydrolysis of TAGs and membrane lipids by lipases 847 355 4118 4191 PMC6142530__F1 Novel agents and pathways under investigation in MDS 3417 3418 2475 PMC6146175__F5 STAT 3 signaling pathway and site of action of napabucasin 3569 847 79923 4313 6010 PMC6146604__F1 Lignin biosynthesis 2539 6120 6955 7086 1431 718 1312 790 PMC6147237__F1 A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity 156 2932 1386 695 PMC6148449__F1 SRP54 and a need for a new neutropenia nosology 6726 6727 6730 6731 6729 6728 79631 51119 3692 PMC6148547__F6 MiR-106p-5p in cervical cancer: from expression to molecular mechanism 3688 5747 1311 7422 2475 2786 2618 2932 5294 PMC6151343__F10 A schematic pathway for rosiglitazone induced HO‐1 expression in HPAEpiCs 7099 10606 3383 PMC6155137__F8 GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway 6010 998 5879 PMC6158369__F1 Primary and acquired resistance to CD38 antibodies 1604 966 952 PMC6160413__F6 Impact of osmotic stress on central carbon metabolism 2203 7072 7167 2819 2026 48 50 2820 100996949 157739 4191 11113 PMC6161786__F2 Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy 3654 7189 10454 23118 3663 PMC6161810__F1 Wound healing, cellular regeneration and plasticity: the elegans way 10399 1612 998 90550 1469 PMC6162708__F1 Canonical and DNA damage-induced NFKB signalling pathways 613 29760 8717 7535 8915 472 685 545 940 7189 PMC6165531__F1 The sugar metabolism (green) and signaling (blue) pathways 5996 8473 51024 26136 PMC6166072__F6 Insulin signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs 1398 355 5163 5164 3630 3643 7249 7248 6009 572 2475 1977 2885 2002 57120 PMC6166072__F8 Phospholipase D signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs 2885 5900 2475 7249 7248 6009 1950 4018 6010 9846 3630 2534 6850 375 4026 551 847 PMC6169142__F3 The protein C pathway 2147 717 5091 721 1431 PMC6171999__F1 Targeting B-cell receptor signaling in leukemia and lymphoma: how and why? 613 4067 29760 695 2885 5880 5879 8205 PMC6172470__F1 Translation acrobatics: how cancer cells exploit alternate modes of translational initiation 83939 1997 10209 1999 1975 PMC6177612__F3 Metabolic pathways of arachidonic acid 4512 5226 5228 PMC6184651__F7 ECM-receptor interaction pathway, (b) focal adhesion pathway, (c) regulation of actin cytoskeleton pathway, (d) TGFB signaling pathway 3611 5728 573 4280 7054 PMC6185869__F1 Simplified PI3K Signaling Cascade and Known Clinical Disorders Caused by Genetic Pathway Activation 5728 5163 207 208 10000 572 PMC6190593__F2 Immunity in Drosophila melanogaster — from microbial recognition to whole- organism physiology 2548 4615 8772 1386 PMC6193731__F3 ROS accumulation induced by fungicidal drugs 6649 6647 1255 759 1215 PMC6196929__F1 Possible signaling mechanisms of SERM actions in neurocognition and neuroprotection 847 1950 627 3479 1499 PMC6199805__F5 GABAergic synapse signaling pathway, with the enriched target genes highlighted in red 1312 7054 9575 PMC6200938__F6 Rag-independent Gln stimulation of mTORC1 via PLD-derived PA 6520 6510 5898 375 5091 6009 8140 PMC6205410__F1 Four hyperglycemia-induced pathogenic pathways which are related to overproduction of ROS and inflammation progression in atherosclerosis 367 2597 7099 1401 PMC6212405__F7 Distribution of the targets of Shenzhu Capsule on the compressed TNF signaling pathway 836 83737 100653365 3976 7008 2353 759 197259 7186 3416 1611 100187907 PMC6213986__F2 Pharmacodynamic mechanism of TCM against HSV-1 7098 57506 2000 3661 9776 2475 PMC6223216__F1 Wnt signalling pathways 4040 4041 324 6259 6010 57216 PMC6230871__F7 Differentially expressed miRNA-mRNA pairs in nuclear factor of activated T cells (NFAT) cardiac hypertrophy pathway from NHE1 transgenic mouse hearts 1489 3976 342538 3479 1610 3480 2885 51083 2932 1384 PMC6232344__F3 Compounds and hitting targets on ICH 7099 5640 1957 581 842 114548 780904 PMC6236198__F6 Cell cycle pathway (the chart is from the KEGG database, gene symbolized by ★ and correlation P values can be found in ) 9126 4087 4088 4089 4193 6502 9184 699 991 5111 1022 1017 4661 1869 4999 8318 PMC6251060__F4 Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease 65018 55669 139341 PMC6266414__F3 Glutamine inter-tissue metabolic flux starting in skeletal muscle, liver, and gut continues in the immune cells 5132 5091 2744 23411 2936 PMC6273039__F4 The molecular metchanisms of natural polyphenols effects on metastasis 10750 5163 2475 999 1000 PMC6274615__F1 KEGG-defined p53 signaling pathway with dysregulated mRNA and miRNA highlighted 1017 472 545 637 4609 581 723778 4193 64065 5728 7249 64326 572 842 PMC6274804__F1 Schema illustrating the regulation of the autophagic pathway under diverse stressful conditions in cancer cells 8408 9776 60673 9474 9140 64422 10533 83734 PMC6275424__F1 Ras/ERK signal transduction pathway with emphasis on p120-RasGAP interactions 126669 5922 889 673 6010 5530 9464 2885 6929 PMC6278270__F1 The main molecular pathways linked to inflammatory and immunomodulatory activities modulated by Curcumin and Echinacea 7099 4615 3553 PMC6283154__F6 Summarization of DDT pathway selection in spn1 strains 338340 51455 80010 PMC6283168__F2 Triacylglycerol (TAG) synthesis in Drosophila: biochemistry and main regulatory pathways 22937 5833 10555 56894 4018 84649 137964 2194 PMC6283168__F3 Triacylglycerol (TAG) lipolysis in Drosophila: biochemistry and main regulatory pathways 23387 5346 9759 123 PMC6288939__F4 Expression differences in males and females in response to reduced insulin signaling for immune response genes 1386 1611 8772 7054 5053 2056 5426 7939 23111 PMC6288939__F6 Expression differences within the IIS/TOR pathway for the four comparison types 5728 5163 207 2475 4609 6194 847 3981 PMC6289770__F3 The lipoyl relay pathway of lipoyl-protein assembly.A 340654 149998 3989 3988 3991 PMC6289780__F4 Representative terpenoid biosynthesis pathway with cognate heat maps for transcript levels of genes 3422 91734 3652 9453 100188864 PMC6290322__F4 Moderate heat stress induces nerve growth factor (NGF) signaling including downstream activation of AKT and ERK as well as cyclic AMP responsive element-binding protein 1 (CREB1) transactivation 4803 1398 998 387 6955 581 2002 391 85451 PMC6291713__F8 JAK2 overexpression alleviates C2C12 myoblasts I/R injury through the AKT and ERK1/2 pathway 3458 7297 3717 6774 572 596 2475 7455 PMC6292568__F2 Candida–streptococcal interactions in biofilm-associated oral diseases 999 253 378427 PMC6304621__F3 General representation of the signaling pathways involved in CBD anticancer mediated effects 9290 7442 51393 PMC6305103__F2 Tumor metabolism regulating chemosensitivity in ovarian cancer 3845 673 4609 4018 5728 57103 2597 5315 PMC6309125__F2 KIBRA/Hippo pathway as a shunt of stressful input 9463 6010 55233 92597 84962 60485 4485 2335 PMC6311566__F1 Overview of metabolic pathways implicated in epigenetic modifications in NSC 100188776 54790 23411 PMC6315745__F1 Chemoresistance 1000 4485 9113 26524 6774 PMC6318995__F7 Characterization of complex transporter-mediated model of carbon allocation and energy supply for oil synthesis in developing P 4118 23457 5091 4018 5183 PMC6321468__F2 The non-polyphenolic compounds’ major mechanisms of action on CRC cells 581 7429 983 PMC6322225__F4 Treatment to health (HTD) network 5091 4023 65057 6955 2 1674 PMC6323179__F6 Proteome changes in (A) G-protein signaling pathway, (B) calcium signaling pathway and (C) ginsenoside synthesis pathway and (D) ribosomes biogenesis, ubiquitin-mediated proteolysis and RNA transport pathway 6185 5091 5901 3652 9669 1999 9631 1998 PMC6330604__F1 DSBR pathways and the effect of RAD51 paralog loss on pathway choice 9656 472 4361 675 5888 PMC6333051__F2 IL-6 signaling in the tumor cell of the bone marrow niche 3717 2885 6774 2475 PMC6335097__F9 Simplified signaling pathway for vasopressin-mediated sodium-chloride cotransporter (NCC) regulation in distal convoluted tubule (DCT) cells 23327 6446 130497 PMC6335350__F1 Interplay between mTOR, AB and Tau in Alzheimer's disease 7249 3667 7248 6009 2475 1977 1020 PMC6335350__F2 Therapeutic approaches in Alzheimer's disease: GSK3 Inactivation therapy: Neuroprotective compounds such as curcumin modulates PI3K/Akt/GSK3B pathway, leading to inactivation of tau hyperphosphorylation 250 2475 23411 PMC6348405__F2 Activation of MRS reconfigures mitochondrial metabolism in yeast 54903 48 1000 999 PMC6349168__F1 Molecular interactions in Immunometabolism governing lipid metabolic disorders 948 6774 85451 PMC6350191__F6 Mitogen-activated protein kinase signaling pathway 4803 6955 1956 2885 6722 4342 4763 2316 3725 7186 355 1616 4149 8195 929 51295 51701 1950 4781 51466 5058 7008 4208 PMC6350575__F2 Differential gene expression involved in the KEGG pathway regulated by TRF treatment, i.e., (a) cell cycle, (b) p53 signalling pathway, (c) FoxO signalling pathway, (d) Wnt signalling pathway, and (e) ErbB signalling pathway 100187761 4609 847 9978 2064 3725 145957 367 PMC6358740__F6 Facets of Theiler’s Murine Encephalomyelitis Virus-Induced Diseases: An Update 7098 51284 4615 83939 8717 8772 7189 7187 3661 3665 PMC6359724__F2 HIF-1-dependent reprogramming of the glucose metabolic pathway, and resultant radioresistance 2539 5163 4601 664 4609 PMC6362006__F7 Schematic depicting ghrelin’s proposed effect on contact dermatitis and psoriasis 8772 7186 8717 3553 PMC6365902__F2 MAPK signaling pathway, which may be dysregulated in TNBC 1610 4351 6722 2316 90459 6402 3725 3952 7124 355 1616 4149 23118 51295 929 51701 1379 100187907 351 57136 PMC6378054__F1 UPR signaling cascade 22926 2744 83939 468 PMC6379582__F6 Model hypothesizing the potential regulation of Beta-catenin by G-alpha subunits and PMT 6010 324 1499 847 PMC6390333__F1 De novo biosynthesis of various aromatic compounds derived from the SHK and aromatic amino acid biosynthesis pathway 1312 6608 84890 1431 5053 1644 7054 412 5805 2271 PMC6391848__F4 Enrichment analysis of differentially expressed mRNAs 6423 5925 5624 PMC6393772__F6 Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways 6648 9839 1000 6714 673 6649 406991 PMC6400555__F3 Models for the roles of Scribble in organizing molecular interactomes involved in synaptogenesis, epithelial polarity, and adhesion, and growth regulation 1739 23513 5063 9231 6010 2195 4485 9113 26524 PMC6400832__F1 The nutritional sensing O-GlcNAcylation 2821 5238 6675 8473 10724 PMC6400995__F1 Kynurenine pathway with a focus on KYNA synthesis 8564 23498 130013 2859 196 4538 4537 PMC6404501__F2 Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury 2475 6009 5163 PMC6405411__F6 Signaling pathways activated by the LH surge in ovulatory follicles 374 3973 2064 2065 2069 3084 PMC6407710__F7 Comparison of the phosphoketolase engineered pathway with oxidative pentose phosphate pathway 5426 10450 6120 324 4200 1431 11113 5185 5183 1636 PMC6410669__F2 Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives 5728 1017 1021 1019 2475 5548 581 355 PMC6415732__F2 Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities 472 6009 8408 9776 60673 581 4975 PMC6419954__F6 G-protein mediated effects on smooth muscle tone regulation 4842 5585 23191 85502 1384 2670 85451 100187761 6010 PMC6421314__F1 Relationship between Fe deficiency responses in dicots and responses to pathogens (necrotrophs or biotrophs that elicit SAR) or to beneficial microbes that elicit ISR 5640 1311 4881 PMC6425516__F1 Epigenetic regulation of peroxisome proliferator-activated receptorA (PPARA) in fatty acid oxidation (FAO) genes (A–C) and PPARA signaling to the FAO metabolome (D) 6256 948 1810 23411 759 PMC6428080__F1 Translational control mechanisms 2069 3479 3569 4803 627 1956 3480 3667 7249 7248 6009 2475 83939 1998 468 PMC6429784__F4 Schematic diagram for anti-ethanol caused damage in K 2078 367 5225 2813 PMC6433817__F4 Some possible interactions between fungal cell regulatory hierarchies that could respond to oxidants and chemical stresses 2878 10413 466 PMC6433975__F2 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of T cell receptor signaling pathway in asthma 1493 962 3932 867 2534 27040 3702 2885 8915 1610 1019 PMC6434849__F7 Interesting putative mechanisms are identified by iPathwayGuide (www.advaitabio.com) on the Glutamatergic synapse and the Chemokine signaling pathways 3416 6855 1610 1191 7054 PMC6440987__F2 Pool sizes of intracellular metabolites in S 5230 2023 4190 5105 4191 100996949 48 3417 PMC6441734__F6 JNK pathways in mammals and drosophila 120892 1386 4199 PMC6443620__F3 Hypoxia-inducible factor-1 (HIF-1) signaling pathway 5728 2475 1975 7428 2056 PMC6449425__F1 Biosynthesis of isoprenoids in X 4598 4597 3652 PMC6450213__F5 Gene network on chemokine signaling pathway by KEGG analysis of module-related DEGs 2885 6714 1794 9844 7074 5058 3702 387 1398 PMC6454043__F1 Ceramide (Cer) synthesis pathways and their cellular compartmentalization 55512 7099 55737 8398 120892 6610 55627 64781 65018 581 2475 PMC6455062__F3 All currently known proteins required for germling communication and fusion in N 27035 998 5619 PMC6458848__F3 DEGs clustered in the PPAR signaling pathway 335 2170 4023 4312 7350 3611 PMC6459169__F3 Transcriptional coverage of penguin transcripts within the vertebrate nuclear factor kappa B (NFKB) signaling pathway (#04064) 1610 27040 29760 7189 3929 7124 4284 6955 4050 100653365 3952 4049 10742 367 PMC6468558__F2 Summary and functional network target analysis of ginsenoside Rb1, which exerts significantly anti-obesity, anti-hyperglycemic, and anti-diabetic effects on diabetes via multiple links across regulatory mechanisms and multi-target effects 10682 3603 5925 PMC6468910__F3 ER stress and chemo-resistance: Role of protein kinase R-like endoplasmic reticulum kinase (PERK) 4942 9817 581 83939 3091 468 PMC6468910__F4 ER stress and chemo-resistance: Role of inositol-requiring enzyme 1 alpha (IRE1), activating transcription factor 6 alpha (ATF6), and glucose-regulated protein 78 (GRP78) 1019 1021 22926 2475 10954 638 572 PMC6470438__F6 Activating p38 MAPK intersection signaling pathway 998 5879 9261 6772 7867 PMC6472122__F5 Transfer RNA-derived fragment target genes in the Kyoto Encyclopedia of Genes and Genomes AMPK pathway map generated using DAVID software 2147 3172 637 355 948 3479 7249 3630 3643 5163 5164 6009 7248 2475 1080 PMC6473282__F6 Proposed regulatory mechanism of estrogen in colitis-associated colorectal cancer at week 2 (A) and at weeks 10 and 16 (B) 7124 2730 2729 114548 4513 PMC6473547__F5 Vitamins on Alzheimer’s disease 102 1020 8195 PMC6477175__F1 Distribution of target proteins of baicalin in the “Alzheimer’s disease pathway” 351 2242 3416 4023 3929 348 572 836 8772 637 6622 718 759 PMC6477175__F2 Distribution of target proteins of icariin within the “Alzheimer’s disease pathway” 351 2242 3416 4023 3929 348 572 836 8772 637 6622 718 759 PMC6477175__F3 Distribution of target proteins of dihydromyricetin within the “Alzheimer’s disease pathway” 351 2242 3416 4023 3929 348 572 836 8772 637 6622 718 759 PMC6477175__F4 Distribution of target proteins of hesperidin in the “Alzheimer’s disease pathway” 351 2242 3416 4023 3929 348 572 836 8772 637 6622 718 759 PMC6477749__F5 Re-analysis of 15 selected genes by KEGGpathway enrichment 5885 1874 4089 4193 6502 9184 991 699 5111 1017 1022 10926 PMC6477881__F2 The mTOR-signaling pathway in ASD 4763 5728 5163 7248 7249 6009 2475 1977 PMC6481333__F10 Microarray and pathway analysis of two COMMA-DB derived clones reveal important differences relevant to their developmental capacity in-vivo 9126 10274 1874 4087 4088 4089 4193 6502 991 699 9184 5111 1017 1022 4661 990 1869 10735 999 PMC6482253__F1 Eukaryotic cell metabolism 7249 7248 5163 55669 9927 PMC64856__F9 Network of metabolic pathways leading from Suc (orange, top left) to the volatile phenylpropanoids, phenylpropenes, and terpenoids formed in EMX-1 basil peltate glands (outlined with yellow backgrounds) 5539 3652 3240 790 1312 PMC6487480__F1 Polyamine metabolism and cancer: treatments, challenges and opportunities 383 196743 54498 4507 84890 353 PMC6489264__F1 Dauer signalling pathway model proposed for Haemonchus contortus 3630 9798 54704 5163 208 6446 207 9437 6649 9436 PMC6491463__F1 The purinome in the MM environment under bone marrow niche metabolic reprogramming 3939 100187907 952 100 84890 PMC6491837__F2 Positive and negative feedback signals for neuronal polarization 627 10371 3479 7474 1000 4067 998 7074 387 5058 8650 6010 PMC6492140__F1 Global and specific regulation of translation initiation 1998 2001 1983 1977 PMC6493027__F2 Ingenuity Pathway Analysis (IPA) of ASS234 treatment 11197 1499 6010 10454 3611 5300 324 51701 4193 960 4316 6925 6422 22943 PMC6499784__F4 Schematic representation of a proposed model of the TBS pathway interaction with PET 2973 2235 4519 5091 PMC6500875__F2 Annexin A1 in inflammation 3383 2358 7124 PMC6505634__F3 MEF-2 isoforms' (A-D) roles in development and tumorigenesis 6009 2475 2353 9499 PMC6509841__F7 DEGs relevant to the “protein processing in endoplasmic reticulum” pathway under group “D vs 2733 9156 4397 258010 100187907 581 22926 1356 1998 7316 468 6402 6500 83939 PMC6509867__F8 Annotated functions of the extracted pathway network 6955 27040 1956 4150 5640 100187761 759 9575 100507043 2774 51083 8139 PMC6512804__F6 Fatty livers demonstrate a premalignant signature 6469 6608 8453 367 7428 2271 51684 836 842 324 6010 5728 1630 PMC6514070__F3 Cellular pathways and major players for the induction of the immediate early genes egr (a) and c-jun (b), and downstream targets, with focus on pathways previously linked to learning and memory in honey bees [, , , ] 1956 2002 2152 PMC6515203__F5 Main signaling pathways activated by growth factor signaling through receptor tyrosine kinases (RTK) and the importance of Mg2+ 1956 5163 2885 7249 6774 6714 PMC6520346__F6 Metabolomic analysis of in vitro effects of OPC-163493 in HepG2 cells 1373 367 8528 PMC6520588__F3 Schematic drawing showing proposed mechanisms of action of Curcuma longa (curcumin) 351 581 10750 PMC6521490__F3 By KEGG pathway enrichment analysis, ANXA2 upregulated filopodia pathway, resulting in cell metastasis 3630 6651 545 6010 5829 7414 2934 7408 2534 1398 126669 PMC6522820__F2 Effect of the PI3K/AKT signaling pathway on gynecological tumors 5163 5728 7249 PMC6523967__F1 Cyclin D1–CDK4/6–Rb pathway in breast cancer 1499 1019 367 7249 2475 595 1021 1017 PMC6524185__F7 Differential genes: the PI3K-Akt signaling pathway 1977 2475 7249 5183 930 6850 5934 5728 572 4170 5266 4193 6009 1975 PMC6524401__F1 Overexpression of IL-6 and its potential negative consequences on the viral immune response 3565 324 920 PMC6527025__F2 Apoptosis Signaling During Arbovirus Infection.Arboviruses exert their effect on apoptosis through different signaling routes 572 83939 8739 8772 8717 PMC6527025__F6 UPR Signaling During Influenza A Virus Infection.Upon IAV infection, BiP is released from UPR proteins (e.g 83939 468 22926 7494 9695 55741 PMC6527386__F1 Molecular factors involved in cell migration 998 5879 25777 23353 PMC6530343__F2 Target sites of therapeutics along the pathogenetic pathway of celiac disease 1232 3133 4277 100507436 7124 920 2669 PMC6532024__F2 Receptor signaling pathways upstream of TRAF6 23586 64127 8767 3654 331 57506 7189 51295 219899 958 84433 79092 8915 10892 PMC6533287__F5 Human mTOR pathway 2475 3630 2887 2885 3667 7249 7248 5163 51256 5728 6009 253260 64798 6446 6010 1977 PMC6534557__F5 Directed acyclic graph (DAG) of the 10 most enriched Gene Ontology (GO) terms and cytokine–cytokine receptor interaction pathways based on KEGG analysis 5640 100187761 64782 PMC6535827__F3 Neuroprotective effects of resveratrol in AD 4513 2876 581 PMC6541445__F3 Cellular mechanisms and signals that coordinate plasma membrane repair 29 6010 998 PMC6545597__F1 Proposed model showing the interactions of Nm23-H1 with cellular pathways 998 6010 79596 PMC6547487__F5 Functional significance of several key genes from four KEGG pathways differentially expressed in female and male magpies 3172 472 29904 324 3716 3717 27040 3725 6095 861 PMC6550088__F2 Focal adhesion pathway (A) and HIF-1 signaling pathway (B) altered in a CRC 7408 3655 5499 998 5747 3611 5728 10627 5906 3912 7791 7414 1793 2316 7975 126669 6651 572 7054 2023 3939 5230 6923 2597 8453 367 6202 PMC6560007__F1 MicroRNA biogenesis 54487 29102 1233 PMC6560203__F3 Hydrogen sulfide interaction and effects upon the activity of its biological targets 759 6188 545 9817 PMC6562660__F2 Downstream effector proteins of the major Rho GTPases, Rac1, Cdc42, and RhoA 387 998 5879 54434 6010 PMC6562738__F5 RAC1 signaling in tumor cells: RAC1 signaling in tumors cells and the involvement of the RAC1 protein in tumorigenesis and drug-resistance as presented in the review 6714 7074 57580 2885 1398 5879 2695 5058 5063 5062 596 2475 PMC6563192__F7 DEGs that are located in the neighborhood (putative cis-targets) of DELs and that are associated with Notch signaling pathway and stress granule formation 8650 3280 23385 83939 388585 PMC6563521__F5 Upregulated genes in proteasome biosynthetic pathway at 24 h after inoculation using F 6119 6117 6118 23237 3458 51371 6120 5979 6184 PMC6567815__F3 Synthesis, metabolic pathways and function of acetyl-CoA 23411 55902 355 47 5091 2597 26330 23410 84532 PMC6568338__F8 Adhesion-dependent and -independent pathways leading to DNA synthesis in ET-1-treated astrocytes 2885 6010 6714 PMC6580974__F9 Network diagram displaying the IAV-dependent phosphorylation changes in the actin cytoskeleton and focal adhesion KEGG pathways 3630 2147 5091 5829 387 5728 3725 1378 324 572 PMC6580993__F9 Simplified signaling pathway: this simplified signaling cartoon encompasses all significant molecular changes detected in this study in spleen, hippocampus, and plasma after PEA treatment (PEA/sal) 5600 1392 2717 3606 627 5226 4018 6497 3553 5465 9290 5467 PMC6581604__F1 Contractility or collagen perturbations result in rapid ~1h changes in LMNA, DNA damage, and cell cycle 4000 367 619537 4001 7054 1506 3014 PMC6581604__F7 LMNA mechanosensing based on a ‘lose it or use it’ mechanism for tension-inhibited turnover that also applies to collagen-I 4313 6722 4000 PMC6584587__F5 Pathway map for “LRRK2 in neurons in Parkinson’s disease” 120892 2932 160 4905 5962 4478 5879 60 2011 1431 PMC6585524__F1 Photic signaling pathways involving main kinases activities in the circadian clock 7432 627 1408 8864 2638 9575 406 5187 PMC6585737__F3 Metabolic drugs and molecular pathways exploitable to drive microglia into a pro‐regenerative phenotype 367 383 23411 4342 PMC6588834__F1 Examples of RRNPP pheromone signaling 266710 4975 6722 6476 PMC6592474__F8 Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness 22926 7186 468 7494 PMC6592856__F3 Hippo signalling pathway: key components and regulatory mechanisms 4771 81532 387 4485 60485 PMC6597298__F7 Schematic diagram showing the critical role of FDPS in normal prostate and prostate cancer and its associated potential mecahnism (s) 5728 2224 6772 PMC6598292__F4 Main biosynthetic pathway for the biosynthesis of cellulose 5183 4118 101448070 PMC6600399__F2 Regulation and role of the PI3K-AKT-mTORC1 pathway in ribosome biogenesis and translation initiation 5728 4193 7249 4149 4609 6009 64798 1999 23367 55323 1975 84232 27250 84271 6194 29904 PMC6600448__F2 Molecular mechanisms of alcohol-induced apoptosis and autophagy in hepatocytes 355 1571 695 8772 2932 1499 595 6774 PMC6600655__F1 Agent that activates the cascade in the MAPK pathway, which can lead to TJs opening or assembly 7043 4316 1950 3082 717 PMC6604479__F2 Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial 5981 875 4524 7054 121278 PMC6611711__F6 Phospholipid and TG synthesis pathway 2194 7038 4018 6611 10400 5091 283871 780904 PMC6616371__F3 Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing 22943 6010 998 2932 324 51176 6932 6259 4920 PMC6617290__F2 Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise 3479 2475 23411 29904 7249 4899 7391 PMC6620530__F2 Highlights of tumor metabolism 3949 4609 2597 5132 7298 55902 1719 2744 2194 3156 3099 PMC6620896__F3 Conceptual model of cellular processes within Tv 6303 112483 170302 PMC6626370__F2 Convergent inflammatory signaling through NFKB potentiates BRD4-dependent transcription of VI mediators, a result suppressed by apabetalone 3146 8717 23476 729230 PMC6626719__F3 Aberrant activation of the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma 4040 4041 1499 324 2932 595 790 PMC6627955__F4 Sphingolipids (SLs) together with the responsible key genes involved in regulating the pathway 5313 2645 5105 2194 6319 64781 9415 7357 3992 355 PMC6627996__F2 TLR2 signal pathway involved in oxidative stress 7097 114609 4615 6647 847 PMC6629462__F1 Transport processes and regulatory mechanisms in A- and B- and non-A, non-B IC 5091 192 51458 57127 PMC6632210__F7 LPS-mediated platelet activation and TLR4 expression in canine platelets 3929 1431 929 7099 4512 PMC6632497__F5 Modulating PI3K-Akt signaling pathway of SCD 2475 8480 613 6850 5934 5728 4099 572 4193 PMC6638189__F1 Overview of RNAi pathways in aedine mosquitoes 29102 192669 26523 27161 PMC6643108__F5 Relation graph of KEGG pathways in which differentially expressed genes were significantly enriched 2353 3918 5601 637 355 9134 5111 PMC6646331__F5 Glutamatergic synapse (path:hsa04724) pathway mapping of the protein targets of DPCs: The location of protein targets of DPCs in the KEGG pathway hsa04724 is represented in yellow and red coloured boxes, red ones are specific to mGluRs 2739 570 367 2717 383 7054 PMC6647379__F3 Tumor microenvironment influences the metabolic status of cancer cells with consequences for their metastatic potential 768 948 355 3949 3156 PMC6657254__F1 Summary of the neuroprotective action of resveratrol 4512 23411 2932 581 PMC6664293__F2 KEGG AD pathway 351 23385 3416 4023 348 572 842 836 8772 637 317 6622 100506742 22926 7124 2932 840 PMC6667928__F2 Pivotal functions of the molecules in heme metabolic pathway in inflammation 7099 857 6850 325 114548 PMC6669704__F1 Prostaglandin biosynthetic pathway 4513 4512 717 5740 5730 5226 PMC6672276__F11 Regulation of vasopressin gene expression in the SCN 2922 7432 9575 PMC6674748__F2 Signaling cascades in axon specification 998 3611 7074 2932 4131 324 8650 PMC6675248__F1 Various molecular inhibitors and stimulators in mTOR signalling pathway 5728 4763 6009 64798 9675 6010 6446 1977 1975 7942 PMC6676114__F6 RNA MODOMICS and heterogeneity of tumors 1956 4609 51441 596 1977 54915 PMC6676405__F2 Putative Cripto-1 targets the MAPK, FA and ErbB signalling pathways 2260 6714 5829 1398 596 PMC6678596__F1 Representation of the main DNA repair pathways involved in platinum salts-induced DNA damage 545 472 79728 7515 675 5888 6741 672 PMC6678715__F3 FGFR signaling pathway 2885 10818 1398 2549 1793 PMC6682659__F3 Molecular consequences of the PrPC/AB interaction in AD 28 4035 2534 PMC6690608__F1 Metabolic reprogramming in CRC 4513 2744 26227 2194 PMC6691976__F1 Metabolic pathways regulated during T cell differentiation 940 7189 4609 6009 3939 2167 2171 4018 5163 3156 2194 PMC6693483__F2 Basic schematic representation of the cAMP-PKA pathway (green) and three MAPK pathways in Candida albicans which are important for morphogenesis, adaptation to stress and survival 998 27010 7018 PMC6693777__F6 Transcriptome analysis of the molecular mechanism underlying immunity- and reproduction trade-off in Locusta migratoria infected by Micrococcus luteus 6502 4485 4193 664 5728 3643 3630 472 3569 1017 6774 10365 1950 2290 57120 PMC6694253__F3 Sub-network of SNHG12 23269 11344 54443 9493 4893 255743 5347 8417 79003 400629 3269 596 7503 4478 6605 387 2113 1788 6996 3135 5747 1977 2475 7248 6009 1975 7249 5894 6850 613 930 5934 5728 572 150365 6693 5266 6256 8453 55225 81786 283120 10785 2597 4193 PMC6696194__F8 Signaling pathway for GSSA via SCARB1 receptor from CD19+ lymphocyte 613 4067 6850 29760 PMC6697704__F1 Main molecular interactions implemented in the model 3082 2549 5163 PMC6704453__F8 The Mb maturation process 4151 11140 80755 10963 PMC6708269__F1 Metabolism and Redox in Pulmonary Vascular Physiology and Pathophysiology 2597 2539 57716 PMC6709869__F2 Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging 9242 6387 998 596 148022 3383 2475 23411 5465 PMC6712457__F1 Linc00152 promotes the proliferation of HCC cells by activating the mTOR signaling pathway 1950 1956 5728 5163 5164 2475 572 PMC6715616__F1 Anti‐ and proviral roles of autophagy in plants 4077 10533 28954 26523 PMC6721595__F1 Human oligodendrocyte precursor cells (hOPCs) incorporate and metabolize nervonic acid 4340 4155 9896 PMC6721808__F1 Simplified scheme of the cellular metabolism pathways important for AML pathophysiology 8140 2475 717 PMC6721808__F7 Simplified model of fatty acid (FA) metabolism 948 5371 2194 PMC6722462__F5 Metabolite pathway analysis with Pearson correlation coefficient only edges corresponding to correlations whose similarity was less than 0.5 are shown 7124 100187761 65057 PMC6722943__F9 Differentially expressed genes associated with the p53 signaling pathway 1017 472 545 637 4609 5277 842 64065 7249 4937 5728 4193 572 759 PMC6724083__F2 Hypothetical network of metabolism in F 2539 100682260 1431 2271 2744 PMC6729444__F7 p35/Cdk5 involvement in RasGRF2 signaling 1950 1956 5924 PMC6737011__F9 Metabolism in WSSV-infected hemocytes showing the aerobic glycolysis, glutamine metabolism and lipogenesis pathways at the WSSV genome replication stage (12 hpi) 11113 3417 3418 1431 2744 4118 PMC6739099__F8 Identification of DEGs relevant to protein processing in the endoplasmic reticulum pathway 100187907 55824 258010 22926 1998 468 4060 6400 9978 8454 PMC6739476__F7 Pathway map assigned for MAPKs signalling 10742 4099 6768 6094 114569 4118 55432 7851 6761 4284 100133941 PMC6742699__F2 Complement-platelet interactions that can facilitate an inflammatory response that favors atheroma formation 7450 718 5196 720 2271 1356 PMC6745797__F2 Intrinsic cancer cell pathways mediate the regulation of PD-L1 expression and MHC in EGFR-mutant NSCLC 1956 2932 11140 2475 4261 4609 PMC6747935__F2 How insulin-stimulated cleavage of TUG and subsequent trafficking of GSVs coordinately regulates multiple physiologic effects 3667 208 3799 4035 29761 PMC6748048__F3 Upstream Regulators of the Hippo Pathway in Drosophila and Mammals 4615 351 23513 4478 4771 92359 64398 10207 154796 6010 4485 26524 3642 6714 3611 9686 PMC6751615__F5 Possible pathways for the synthesis of bioactive stress mediators from the arachidonic acid (AA) cascade in the immune tissues of chickens 4512 6418 26136 PMC6753107__F1 Schematic diagram of the BPV system based on a two-species microbial consortium with constrained electron flow 4519 8775 5091 PMC6753234__F8 Microbiome–gut–brain axis in relation to AD 5053 5091 79888 PMC6754541__F3 Genome-based metabolic model for cable bacteria with emphasis on electron flow and energy conservation during oxygen and nitrate-dependent sulfide oxidation 4841 1638 4519 PMC6755251__F4 T-cell receptor signaling pathway 867 2534 27040 3702 2885 3565 3586 1019 8915 1610 3932 1732 PMC6757264__F7 Mitogen-activated protein kinase signaling pathway in lung squamous cell carcinoma 8314 4351 6722 2316 3725 7124 355 1616 4149 929 23118 7189 51701 4703 PMC6760864__F3 New insights into cytoskeletal remodeling during platelet production 11252 387 998 5062 9948 PMC6764236__F2 Regulation of neutrophil metabolism 2475 95 355 PMC6766639__F4 Impact of IT on mitochondrion-related gene expression and on selected mitochondrial outcomes in tissues collected from UCD-T2DM rats at 1.5 mo-post surgery 8760 1040 9489 283871 114971 54675 1431 PMC6769927__F3 Transforming growth factor B (TGFB) family SMAD-independent signaling 6464 2885 331 203 10454 9261 85451 1051 1386 6667 PMC6770103__F4 Differentially expressed genes in the neurotrophin signaling pathway between mandarin fish at CG and LG from a transcriptome analysis 1398 10818 2885 627 126669 7189 5879 351 PMC6770103__F5 Differentially expressed genes in the cyclic AMP (cAMP) signaling pathway between mandarin fish in the control group (CG) and the learning group (LG) from a transcriptome analysis 51738 3092 268 6010 5468 PMC6770252__F3 Biological origin of free radicals and their effect on cell viability 50507 22926 468 7494 581 PMC6770560__F9 Coelonin inhibiting LPS-stimulated activation of NFKB and inducing G1 phase cell-cycle arrest in RAW264.7 cells 7099 5728 4615 7189 PMC6775293__F8 Pathway of Alzheimer's disease 351 768 23385 3416 4023 348 572 836 842 8772 317 100506742 3659 7124 PMC6792490__F7 Colorectal cancer pathway enriched in KEGG 4434 4087 324 387569 572 842 836 2956 581 51426 1950 2475 2078 8213 367 3725 PMC6798062__F1 RAS pathway in cancer 10013 22933 8859 8216 4763 7074 572 2475 6010 2353 4609 3725 PMC6799833__F4 Autophagy pathway 7405 81671 7248 55626 22863 6009 64422 8408 10533 9776 9140 9474 55054 PMC6801309__F1 An overview of myocardial energy substrate utilization 95 948 1376 PMC6811524__F2 Non-canonical/Beta-catenin-independent Wnt signaling pathways 23002 387 998 PMC6822174__F1 Cell metabolism 2194 95 47 2271 2744 PMC6823401__F10 Figure shows an MPR route that gets activated by the stimulation of progesterone receptor and has a role in cell proliferation by upregulation of PKA/cAMP by the activation of CREB/CREM/ATF-1 2885 2549 6667 1499 6009 6774 6714 1977 6194 1956 PMC6825310__F4 Executable network model as seen in the BMA tool 7471 7428 1499 4513 1950 664 4609 4193 4149 5728 2114 1017 10131 1019 2146 572 4170 PMC6830349__F2 Cell structure and function 286205 11047 1020 1201 55432 717 7353 PMC6830765__F1 NFKB pathway and the inhibitory effect of various alkyl nitrate N-Aryl Piperamide on NFKB translocation and COX-2 function 8775 4615 3553 PMC6833007__F1 Mechanisms involved in activation and regulation of NLRP3 canonical pathway 3603 8011 22933 5610 4615 PMC6833135__F3 Gene expression levels of central carbon metabolic pathways 5236 55276 7167 7054 127 2026 128 4191 4118 11113 48 50 3417 3418 11 PMC6834155__F4 Non-genomic actions of thyroid hormone 6957 6955 2475 5214 PMC6834478__F2 Mouse models used to study the PI3K/AKT/mTOR axis in PCa 5728 64798 5371 7248 6009 9675 PMC6844540__F12 PI3K-AKT signaling pathway adapted from KEGG (ID: hsa04151) (A) the predicted targets and genes were signed in red; (B) the known targets and genes were signed in red 2475 10682 7249 613 930 1191 5728 5934 572 5266 1977 6009 1975 5894 6850 4199 4602 4193 PMC6855049__F6 Antifracture pathways of potential targets for treating fracture from main active ingredients of Drynariae Rhizoma 7124 3727 7189 23118 1386 2885 5894 998 6714 6256 2932 4609 351 PMC6857915__F8 Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease 8650 100188776 23385 PMC6859544__F1 Redox Regulation in Glucose Metabolism 6647 2539 847 355 PMC6859819__F3 TRK signalling pathway 4803 122769 2885 717 PMC6861914__F7 Apoptosis pathway in LNCaP cells treated with LEP (1 × 10−6 M) 4199 7186 1616 839 8520 790 835 572 8739 8772 759 7011 PMC6865805__F2 Chronic infection of H 9140 9474 55054 2475 PMC6874879__F1 LKB1-proficient tumors display coordinated control of metabolism, DNA repair, and mitochondrial dynamics 92335 7249 2475 56947 PMC6878006__F6 Predicted localization of proteins and biosynthetic pathways in Synechocystis 4335 2242 4519 2152 5091 2230 275 PMC6887687__F1 Main signalling pathways of programmed necrosis in cardiomyocytes 8717 7186 1540 197259 8772 9365 PMC6888166__F1 Signal transduction of the unfolded protein response (UPR) 22926 83939 468 7494 PMC6888321__F3 Cell signaling pathways activated in osteogenesis and angiogenesis models: Wingless-related integration site (Wnt) pathway, bone morphogenetic protein (BMP) pathway, and fibroblast growth factor (FGF)/platelet-derived growth factor (PDGF) pathway 828 1499 4090 4086 5163 860 222663 PMC6888570__F2 Canonical KEAP1/NFE2L2 antioxidant signalling pathway, induced by electrophilic ligands 9978 4780 9817 PMC6889432__F1 EGFR and PI3K signaling pathways in CRC 1950 5728 1956 5163 2885 7249 7248 6009 4609 2475 2000 PMC6889822__F4 Multiplexed Proteome Profiling of Carbon Source Perturbations in Two Yeast Species with SL-SP3-TMT 48 50 3417 3418 PMC6890721__F4 Caffeine, theanine and catechin biosynthetic pathways in plants, and expression patterns of genes related to quality metabolites in ‘Xiaoxueya’ leaves 2572 64853 1431 2147 7498 2638 PMC6890794__F7 Summary of changes to the Wnt pathway as a result of AD + TS treatment 1499 836 960 6774 PMC6893972__F7 Neuronal molecular pathways indicate glutamate and dopamine receptor signaling, in a representation of 45-day cerebral organoid proteomes 1312 7054 56934 5662 2744 PMC6894939__F2 Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? 101448070 2203 4118 5105 5106 5091 11113 8789 PMC6902895__F2 The biosynthetic pathway for argyrin production in Cystobacter sp 384 1356 383 PMC6905557__F6 Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound 4171 54707 5000 27030 5981 699 5317 117286 998 PMC6921378__F5 Molecular models of the potential role of proteins involved in the Nrf2 – mediated response to NCC exposure 56954 325 920 324 468 22926 PMC6923491__F1 Pathway diagram of axon regeneration regulatory network 4803 627 2549 10818 1398 2885 387 4948 2932 PMC6923491__F2 Bayesian theorem-optimized possible optimal acting pathway of axonal regeneration 4803 627 8544 2549 10818 387 2885 1398 4948 2932 PMC6925433__F4 The insulin signal pathway 867 355 3630 3643 7249 6009 572 2475 1977 2885 PMC6927459__F6 CXCR4 and PaCIC survival and motility 7852 7103 596 1499 6608 6469 998 100653366 6010 847 PMC6928143__F4 mTOR signaling pathway was involved in NFPA 2078 253260 6009 5478 6010 6194 1975 PMC6928143__F5 Wnt signaling pathway was involved in NFPA 324 1499 387 998 1386 759 4878 PMC6928143__F6 ERK-MAPK signaling pathway was involved in NFPA 2885 1398 6714 5829 4351 4342 7444 572 1977 4609 6722 PMC6928836__F1 A schematic illustration of unfolded protein response (UPR) and the effects of salicylic acid (SA) under stress condition in plants 1431 847 4881 367 6295 PMC6932941__F3 Diagram of the pathways involved in the metabolic interaction of glycolysis, mitochondrial respiration, and hyaluronan synthesis 8473 23152 960 5132 PMC6936658__F5 Significantly down regulated genes (from the current study; PLIN1, SORBS1, FABP4, etc) involved in the PPAR signaling pathway is highlighted in red color 335 5360 4023 3611 PMC6941427__F4 Differentially expressed genes (DEGs) involved in flavonoid metabolic pathway and lignin metabolic pathway 790 2638 2641 PMC6941427__F6 Differentially expressed genes (DEGs) involved in terpenoid metabolic pathway 4015 252842 4598 259283 9656 3652 PMC6949159__F5 KEGG pathway: CELL CYCLE (A) and P53 SIGNALING PATHWAY (B) 6502 699 4661 472 545 637 4609 4193 64065 84883 7249 5728 6477 PMC6950413__F1 Summarized natural and heterologous pathways for beta-carotene production investigated herein 5183 10654 3652 PMC6950849__F1 Central role of TORC1 signalling pathway and importance of wild alleles for yeast nitrogen consumption 100187761 54826 4881 348654 83939 PMC6953115__F2 Epac1 signalosome in cardiac stress conditions 7222 3418 9759 10014 PMC6959099__F1 Catabolic and anabolic metabolism in the cell 2597 4942 384 435 PMC6962107__F2 L-ornithine biosynthesis metabolic pathways in C 5805 7086 847 PMC6962170__F4 Integrated metabolic, proteomic and transcriptomic functional analysis 2554 79094 11255 57038 10768 4507 10376 27430 443 54498 3276 157739 211 6774 PMC6972624__F10 Proposed model 4609 1610 9978 PMC6975221__F5 KEGG pathway of cardiac muscle contraction (a) and PI3K-Akt signaling pathway (b) 845 6262 10345 3270 3371 2475 6009 4609 716 572 5728 6256 4193 PMC6981480__F1 ER-stress induced UPR signaling 83939 468 22926 PMC6985875__F1 Mitochondrial function and localization in various lung epithelial cells during homeostasis 51024 56947 55669 4976 9927 7019 65018 9474 PMC6987096__F8 Schematic diagram that depicts platelet-induced estrogen biosynthesis in endometriosis 1844 200186 7392 3284 PMC6997863__F1 Different pathomechanisms linking DM and AD 351 348 4035 PMC6999540__F1 An overview of metabolic engineering of Y 7498 7504 2539 2819 4199 355 4018 1896 8504 3652 727 PMC7002987__F1 Different signaling pathways regulating melanogenesis 3082 4157 4286 PMC7005066__F1 Unfolded protein response (UPR) signaling during bacterial infection 22926 83939 468 7097 3577 8772 759 PMC7006399__F6 Gene network analysis and interaction subnetworks 5145 6010 2780 1536 2779 3693 821 811 3685 92579 3098 5105 8660 2475 5500 1737 673 2932 5584 5230 501 PMC7010923__F2 Proposed model for signaling pathway of fibrosis in MDC1A 59272 367 3611 2475 51199 PMC7013392__F4 Representation of the targets of stemazole (ST) involved in the MAPK signaling pathway 4351 6722 4763 3727 8717 7186 355 1616 4149 929 51295 51701 PMC7013599__F4 Gene expressions in the fatty acid biosynthesis pathway (Ko00061) in response to Bgt infection 2194 2184 355 2242 2091 PMC7013724__F3 Mitochondria unfolded protein response (UPRmt) 468 59286 8192 PMC7013742__F2 Putative SUR1 molecular signaling pathways beyond cerebral edema in brain injury 6667 160065 4843 6347 2670 581 7099 54795 5340 7222 PMC7016856__F2 Anti- and pro-fibrotic roles of Epac1 in cardiac fibroblasts 7040 7048 7046 7018 PMC7017262__F2 Molecular H 5879 1445 7410 1839 6868 1956 8153 2065 6010 PMC7017752__F2 Emerging therapeutic targets for neurofibromatosis type 1 (NF1) 2885 4763 9610 5900 2475 PMC7022656__F1 Inhibition of Nrf1 N-glycosylation by tunicamycin (TU) in the endoplasmic reticulum (ER)- to-nuclear signaling responses 83939 22926 468 4899 7494 PMC7022656__F9 Cross-talks between distinct signaling pathways activated within different ER-to-nuclear responsive networks to the classic ER stressor TU 22926 4899 55768 84301 414301 83939 468 2730 7494 PMC7022772__F6 KEGG proteasome pathway shows involvement of downregulated cytoplasmic 6184 6185 23237 6102 3458 51371 PMC7026265__F4 Pharmacological strategies to control endoplasmic reticulum (ER) stress in diseases 10330 22926 83939 7494 468 PMC7027163__F1 MAPK cascades 351 2002 2113 6667 PMC7028706__F9 Protein–protein interaction network generated for shared miRNA target genes after miRNET analysis 7975 266710 100 156 7124 6868 3458 3717 PMC7029504__F7 FOXO signaling pathway enriched in KEGG 4089 4088 51701 6502 4193 664 9140 5728 3630 3643 472 1017 6774 10365 PMC7030939__F7 Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity 3949 5371 387 2152 30846 273 23440 832 55737 84313 100170220 PMC7030939__F8 Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity 9341 811 7099 929 7097 10333 10011 948 83547 203068 4353 4074 PMC7031469__F1 Action of metformin in the neuro-glial environment 581 3553 207 8989 2475 627 23411 1195 8408 351 PMC7033549__F9 A working model depicting the relationship between proline and polyamine in wild type, PvP5CS OE and RNAi transgenic plants under control and salt stress conditions 100653366 5625 4942 PMC7039202__F4 Regulation of the SGOCP 7249 7248 83939 468 23081 PMC7040003__F5 Differential expressed genes in the hormone-mediated ovarian maturation pathways in the polychaete-fed group 2798 9140 811 991 324 995 5062 PMC7040073__F5 Changes in the transcript abundance of genes involved in central metabolic pathways, fatty acid biosynthesis, and the PKS-NRPS pathway 2821 5226 355 2023 95 8564 23498 PMC7041258__F4 Gene expression analysis by IPA software (FC ≥ 1.5 and p value < 0.001) showing nuclear factor erythroid 2-related factor 2 (NRF2) oxidative stress response path design activated in NR8383 cells after exposure to ¼ IC50 of NM403 for 4 h 9817 8452 4094 5629 PMC7045390__F6 Correlation analysis of the hypoxic transcriptome and metabolome data 6886 55276 7167 5230 2023 84249 10072 6675 252842 48 50 4190 3417 3418 383 PMC7047328__F2 Tryptophan breakdown via the kynurenine pathway and its interactions with the immune system: This figure illustrates tryptophan breakdown via the kynurenine pathway 3620 169355 196 920 8564 23475 7454 PMC7048048__F1 Core networks generated by the redGEM algorithm from iJN1411 genome-scale model 65220 6120 1896 847 4200 4118 5091 1431 84890 52 PMC7056466__F1 Hydroxytyrosol (HT) and its main biological actions 3717 6774 581 PMC7057456__F3 Visualization of identified KEGG Cell Cycle pathway routes 9126 5885 4089 4193 6502 324 991 5111 993 1017 1022 8318 1874 4999 23595 PMC7058019__F2 Development of a CRISPR/Cas9n-based tool for metabolic engineering of Pseudomonas putida for ferulic acid-to-polyhydroxyalkanoate bioconversion 8772 26136 95 716 PMC7058937__F2 Cell junction formation and maturation under RhoGTPase control in epithelial cells 5879 387 100187761 6010 8650 382 998 PMC7059126__F1 Illuminating insights into opsin 3 function in the skin 5091 8989 4157 4286 PMC7059563__F4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.A KEGG pathway analysis revealed 15 substantially enriched pathways corresponding to transcripts dysregulated after spinal cord injury (SCI) 7124 836 3976 3569 8717 PMC7059830__F1 Glycolytic-lipogenic pathway in TH17 cells 940 3099 2475 355 4609 3156 3939 PMC7062075__F4 KEGG metabolic pathway map showing significantly differentially expressed genes within the cell cycle pathway for midgut control versus UCS 1874 4089 699 9184 1017 1022 6502 2161 PMC7077540__F9 CXCL12 and receptor CXCR4/CXCR7 in placenta accrete spectrum disorders (PAS) 6387 7852 5879 998 6010 PMC7084677__F1 Canonical phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin pathway 65018 55486 55626 PMC7089929__F4 Distribution of differentially expressed genes (DEGs) of the cell cycle pathway (dre04110) in diploid and tetraploid states in vitro and in vivo 5885 6502 9184 699 5111 1017 1022 5347 4661 2161 10926 PMC7093293__F4 Role of Rho/Rho-kinase pathway in the pathogenesis of cardiovascular diseases 6010 6844 4282 650 PMC7097199__F2 Signal transduction by SUMO 2885 3725 6608 PMC7102672__F5 Enriched DGEs in the PPAR signaling pathway There were three pairwise comparison groups (CG vs HS, CG vs HR and HS vs HR) in our study, and there were three kinds of DEGs from the different comparison groups 335 5360 10297 4023 4312 7350 3611 7316 364 PMC7103590__F8 Expression profiles and prognostic significance of WNT family members in glioma via bioinformatic analysis 51701 9350 324 4089 25805 50964 6477 6500 8454 8178 387 9475 27130 6259 1950 126669 5728 2475 4193 PMC7110753__F3 Hypothesized dauer signaling during N 3479 5728 5163 9798 54704 6446 6497 100 9437 PMC7110906__F1 PI3K/AKT/mTOR signalling pathway 5163 5728 2475 64798 4193 572 1999 PMC7114592__F2 Role of MNK1 in viral mRNA translation 2885 3178 671 PMC7116212__F6 Ribosome biogenesis pathway showing genes which are significantly changing upon sodium azide treatment of wild type cells 11201 6949 10528 51602 4809 55651 1736 54433 55505 84135 84916 10436 51096 9790 5822 55813 55272 92856 6023 28987 5901 51068 55341 4733 PMC7122270__F2 Type I/II cells 8772 637 331 PMC7139386__F1 Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium 7358 51083 2582 2592 101448070 2584 PMC7139475__F2 Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea 627 6446 2932 23411 54623 114548 4803 1641 3553 PMC7139621__F1 Therapies fighting breast cancer through the fibroblast growth factor receptor (FGFR) pathway 5806 10818 2885 2475 1019 PMC7140047__F2 Rac1 signaling pathways and their biological significance 5879 3984 3985 5347 572 10811 5728 387 6010 6774 PMC7140927__F1 Sensing mechanisms for abiotic stress in plants 23379 1959 2077 6655 6654 PMC7143458__F3 Location of differentially expressed genes (indicated by red boxes) in the purine metabolic pathway 4975 8205 100187761 PMC7149230__F5 Synchronization of central carbon enzyme and metabolite abundance with cell cycle phases 5236 7167 2026 4190 11113 4118 50 PMC7151181__F3 Signal transduction pathways activated by GlcNAc 27010 7006 100124696 PMC7158159__F6 Detailed signaling pathway of G-protein coupled receptor 2534 2868 6714 5163 2922 6774 PMC7161517__F3 Renin-Angiotensin System Interaction With COVID-19Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors 1636 59272 22808 PMC7168252__F1 Beclin 1 function in autophagy and the role of its post-translational modifications implicated in cancer 22863 60673 8408 9776 7405 1956 613 PMC7175142__F1 Main apoptotic pathways 7494 637 596 22926 8717 8772 PMC7175142__F3 Influence of lipid mediators on the mitochondrial pathway 4513 5226 3611 PMC7178451__EV1 STAT3‐dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer 8027 2670 3458 7076 7428 2056 9118 4282 3939 PMC7184931__F2 Metabolic control of T-cell related to tryptophan metabolism 196 2475 324 7054 PMC7185074__F6 ‘mTOR signaling pathway’ 2475 6520 64798 6009 1975 5728 PMC7185565__F2a Emerging Themes in PDZ Domain Signaling 8573 9463 1739 85358 10207 7074 10755 4041 4920 23002 1499 6010 PMC7188829__F5 DEGs enriched in TNF (A), PI3K-AKT (B) signaling pathway during A 8772 8717 10682 1636 5879 613 930 84188 572 150365 4193 PMC7196371__F12 Functions of exercise in AD 3066 627 8841 3553 PMC7196481__F3 Expression profiling of winged and wingless destined pea aphid embryos implicates insulin/insulin growth factor signaling in morph differences 3479 3630 1950 3643 1956 2885 4485 5728 4089 51701 4088 6502 4193 1017 7874 2290 901 664 10365 5897 5896 9140 472 3575 PMC7198750__F2 Depiction of the cGAS-STING pathway 6573 8408 25939 11277 472 100187907 PMC7199713__F2 Herbal medicine on the extrinsic pathway of apoptosis 355 8717 995 4615 8772 983 331 5163 1017 PMC7201019__F5 Pathways of viral sensing and TLR signaling, metabolism, cell motility and protein export are enriched in the NK RMtsig 4191 54884 1520 3425 7389 226 3033 4067 2990 6761 3725 7010 5091 2353 176 5970 7390 9973 2475 132 2316 7038 1211 5728 8775 387 140892 PMC7204005__F3 miRNA-28-3p promotes cell proliferation through the MAPK signaling pathway and participates in the regulation of diabetes 7124 8717 6714 7186 2885 7189 5879 5008 998 3725 596 2002 3297 9261 PMC7213295__F1 PI3K/AKT/mTOR/NFKB Pathway in Ovarian Cancer 5728 5163 8821 7248 2475 64223 7249 6009 64798 PMC7215355__F1 Lipid metabolic processes during HCV RNA replication, assembly, and egress 22931 4547 27141 348 5007 5091 6319 PMC7215397__F3a Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA) 3791 5829 2885 7414 PMC7215987__F2 Main components and crosstalk between the Ras-Raf-mitogen-activated protein kinase-Ras- extracellular signal-regulated kinase (Ras-Raf-MEK-ERK) pathway, the spleen tyrosine kinase (SYK) pathway and the PI3K-Akt-mTOR pathway 5728 5163 3667 6714 6850 7249 7248 6009 572 64798 1977 PMC7220691__F4 KEGG pathway of pathways in small cell lung cancer 2272 51426 581 1017 836 317 6502 4609 5728 7851 PMC7224363__F1 Chemical reactions triggered by Δ9-fatty acyl-CoA desaturase, EC:1.14.19.1, also known as Stearoyl-CoA-desaturases (SCD), introducing a double bond and thus affecting lipid metabolism 355 8322 4040 324 8312 1499 8314 2879 3156 PMC7226606__F1 Metabolic reprogramming in cancer cells 1950 6714 5728 4193 23410 2023 47 3939 PMC7227035__F6 EGFR (a) and NFKB (b) pathway-focused RT-PCR gene expression analysis of representative TNBC PDX RNA samples collected before and after Pan-HER treatment 1950 6774 2475 2002 6722 3725 5971 PMC7230881__F7 Summary of the cellular response to oxidative stress in CC4348 (A) and the gpx5 mutant (B) 2936 2876 2880 PMC7234907__F1 MET receptor tyrosine kinase engages intracellular molecular signaling pathways and controls neuronal morphological development 3082 2475 998 3064 5879 3984 PMC7236057__F8 Possible mechanisms of La2O3 NPs contributing to the apoptosis of testes tissues 594857 9817 1586 3553 PMC7237829__F1 Endoplasmic Reticulum Stress Signaling in Cancer Cells 51493 468 83939 22926 PMC7249037__F6 KEGG pathway for colorectal cancer 324 4089 387569 572 3725 842 836 4397 1630 4088 581 51426 1956 2475 374 PMC7249743__F8 Potentially HCC-related KEGG pathways 9126 1874 4087 4088 4089 4193 6502 9184 699 5111 1022 1017 983 8318 999 1869 51071 4999 23595 1019 472 545 355 637 581 4609 836 10572 94005 64065 84883 3486 2475 3479 7249 5728 64326 PMC7251756__F1 Glucose Metabolism and De Novo Lipogenesis (DNL) in Adipocytes 55902 47 2194 1431 PMC7263378__F4 Synchronized redox regulation of cysteine residues throughout canonical EGF signaling pathways at 15 and 30 minutes 7076 7077 4313 6010 1950 1956 4035 999 1785 382 4830 2885 6714 1499 157313 324 1604 2475 6194 52 10605 1072 7157 572 2000 790 PMC7263595__F1 Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae 27235 51004 51805 84274 10229 57017 51117 PMC7265888__F2 Annotated KEGG pathway of Endocytosis (A), Peroxisome (B) and MAPK signaling pathways (C) about differentially expressed genes 3949 1956 638 273 30846 2695 8027 51028 1121 3792 5805 5191 5190 9409 8504 55670 5828 5192 5193 5824 5827 4358 11264 5264 847 5052 8540 23600 2053 1628 570 30 373156 4598 10654 7498 283927 390916 55825 23417 54677 1610 8528 183 51268 3155 196743 10901 6955 1950 6722 2885 10752 3725 7186 355 1616 4149 23118 929 51701 PMC7268359__F6 Schematic diagram of the mechanism of soyasaponins’ regulation on TLR4 signaling pathway 3929 929 114609 4615 3654 7189 3553 PMC7272579__F5 KEGG database pathway hsa05200: pathways in cancer 4193 581 51426 1021 1019 1017 PMC7272692__F4 Mitotic/endocycle switch 4602 1611 7272 983 7465 4661 1017 PMC7275405__F8 Graph of the interaction pathway 3973 3643 3949 366 343 64241 6256 7363 1576 PMC7278812__F3 Selenium-dependent antioxidant system of glutathione peroxidases (GPx) and thioredoxin reductases (TrxR) 2876 2879 2539 PMC7282681__F2 Schisandra chinensis on Alzheimer's disease signaling pathway 351 23385 3416 4023 8542 572 842 836 8772 637 317 1630 22926 7124 840 PMC7285791__F4 Bioinformatics analysis of YRDC-mediated hub protein-protein interaction networks in NSCLC 55052 5433 5691 5693 5709 891 9134 9133 5718 5686 51529 5719 4998 92856 10213 1736 55813 29889 9184 5111 5983 56984 5557 PMC7290932__F1 Diverse signalling pathways initiated by maturation initiation hormones (MIHs) lead to a universal biochemical core, activating maturation promoting factor (MPF) 10776 4342 4661 7465 983 PMC7298284__F1 Cyclin B1‐MAD1 interaction promotes checkpoint signaling at kinetochores 891 7175 324 983 4163 9184 57082 10403 83540 PMC7303777__F2 Insulin signaling pathway 355 2308 6389 3643 5163 5164 3630 7249 7248 6009 572 2475 1977 2885 2002 PMC7309569__F3 The dolichol-linked oligosaccharide (DLO) biosynthesis pathway 56052 10195 29929 PMC7311088__F1 Synthesis of Fluorinated Amide Derivatives via a Radical N-Perfluoroalkylation–Defluorination Pathway 2023 367 7054 PMC7314846__F3 N6-methyladenosine (m6A) methylation in ischemia–reperfusion injury 3976 8772 2932 6774 595 1026 PMC7316955__F3 Representative pathways of differentially expressed genes 4117 8528 351 465 2475 3630 3953 3569 PMC7318778__F2 Dendritic cell metabolic reprogramming in tumor immune evasion 3620 216 7494 1499 4481 7474 PMC7322915__F1 Effect of caffeine on Cdc25 regulation in S 5810 1040 7465 324 PMC7325921__F2 Quantification of intracellular carbon energy metabolism 5313 100188864 2203 5105 5236 5091 2695 6513 PMC7326904__F1 Evaluation of Silencing Effect of miR-133a-5p Mimic on TIM-3 Expression in AML (HL-60) Cell Line 7124 355 2885 8717 7186 1616 51295 2645 4351 51701 3725 6722 PMC7327232__F4 Membrane receptors on parietal and enterochromaffin-like (ECL) cells and intracellular signaling pathways that regulate gastric acid secretion 846 1956 7039 1950 PMC7333221__F1 Origin of B-cell-associated malignant tumors and the anti-tumor mechanisms of HDAC6 inhibitors 10013 5132 2308 1499 PMC7334043__F2 Primary metabolic pathways of R 2820 2819 7167 4018 4199 100996949 5131 5192 316 48 50 4191 4190 3417 3418 3422 PMC7335243__F3 Possible viral entry and replication mechanism of SARS-CoV-2 1636 59272 51199 PMC7335402__F3 Relevant biological network containing the DPTs and their associated genes () was constructed using Cytoscape version 3.8.0 60673 9776 9474 9140 83734 PMC7337081__F1 Modular Organization of Cis-regulatory Control Information of Neurotransmitter Pathway Genes in Caenorhabditis elegans 1103 43 59272 7018 100996569 574 8168 28964 5817 161823 PMC7344258__F1 Cysteine is a core player in the cellular metabolism 5212 875 847 4609 2539 2821 2597 3845 5091 PMC7346763__F2 The transmembrane receptors for CSPGs and myelin-associated inhibitors and the signaling pathways downstream of two receptor protein tyrosine phosphatases (RPTPs) 4099 387 324 4131 PMC7348171__F2 Functions of NgBR include regulating cholesterol trafficking via directly binding to NPC2, hepatic FFA and TG metabolism through inhibiting LXRA transcription in an AMPKA‐dependent pathway 2194 5894 7038 10577 4193 2932 7422 PMC7349525__F3 PD-related proteins and chaperones involved in proteostasis: Other well-characterized PD-related proteins, their cellular localization and functional pathways involved are depicted in this figure 9529 573 11140 9532 3313 65018 55737 120892 23400 9829 PMC7349538__F9 Biological model proposed for the yeast response to stress caused by inorganic acids 2619 2936 4281 PMC7349630__F2 Signaling pathways and mechanistic drivers of epithelial-mesenchymal transition (EMT) and endothelial-mesenchymal transition (EndMT) in age-related macular degeneration (AMD) 1499 2475 999 1003 7450 PMC7350255__F8 Representation of the KEGG protein process in endoplasmic reticulum pathway 9156 759 4397 100187907 6476 258010 22926 100506742 468 6402 55850 7316 PMC7352181__F2 Angiotensin-associated pathways associated with cell proliferation, invasion, and migration in lung tumor microenvironment 6770 1636 59272 4846 PMC7352181__F4 Angiotensin-associated immunoinflammatory pathways in lung tumor microenvironment 59272 1636 4846 PMC7352479__F2 Oxidative stress pathways 9817 2475 6009 4094 7249 7248 5163 5728 PMC7355474__F8 Graphical representation to elaborate on the possible mechanism underlying antioxidative and anti-inflammatory potential of A3 against the p-MCAO-induced brain injury 596 7099 4094 PMC7368990__F6 Schematics of glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway showing changes at the translational level of enzymes involved in the different steps 22934 57103 25796 2539 5226 2821 2203 7086 6120 2147 8789 2597 47 1431 2271 4967 2744 PMC7369957__F1 Canonical Wnt pathway 324 847 4040 4041 PMC7370084__F1 Summary of the signal transduction pathways through which acupuncture treats nervous system diseases 7099 4615 572 581 466 6772 2002 4609 4149 PMC7370084__F3 Four p38 MAPK isoforms are p38A, p38B, p38G, and p38D 1938 1386 2002 PMC7370084__F4 P38 MAPK signaling pathways 958 4615 1616 6010 7186 5879 10454 29904 83939 7189 466 6772 2002 4609 PMC7376555__F4 Schematic model illustrating cellobiose-elicited action of ER stress and lignocellulase synthesis 999 81620 80157 11231 23480 7095 PMC7381619__F1 Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression 406905 2638 406947 574506 3005 693219 284837 574449 283120 378938 9817 2242 693223 5820 PMC7382779__F4 Functional Relationships by Gene Ontology (GO) Enrichment Analysis of Protein Regulation Networks and Phosphorylation Regulation Networks 4553 28990 7911 2023 5230 7167 PMC7394371__F3 Gene expression profile analysis of the rabbit retinal vein occlusion model 4117 9118 100996569 27040 7939 1431 8027 140892 2444 1610 4513 572 84890 4221 132 7186 6955 4049 PMC7395405__F4 Schematic diagram of signaling pathways in exosome-mediated autophagy inside target cell 1956 5163 5728 7249 7248 6009 2475 6774 9776 PMC7395594__F6 Nrf2/Wnt/immune crosstalk in oxidative stress and inflammation in PD 847 9817 324 7124 4513 7474 PMC7396304__F1 Quantitative Measurement of Redox State in Human Brain by 31P MRS at 7T with Spectral Simplification and Inclusion of Multiple Nucleotide Sugar Components in Data Analysis 2597 4191 101448070 PMC7396583__F8 Model illustrating potential regulation mechanism of membrane lipid metabolism in peanut cold tolerance 1373 150763 4018 8694 5091 51 30 PMC7396774__F5 Re-analysis of 14 selected genes using KEGG pathway enrichment 9126 1874 4087 4088 4089 4193 6502 324 9184 991 5111 993 1021 1019 1017 1022 983 999 990 8318 4661 1869 8317 10926 4999 PMC7397096__F7 Myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice 958 7099 3565 867 3566 5163 2309 860 5241 1655 8841 6863 2885 27043 10498 627 9611 5091 PMC7397746__F1 Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids 4018 5662 10390 PMC7401422__F3 Visualization of the cell cycle pathway from WikiPathways 5111 5426 5427 PMC7401802__F1 Biosynthesis of CL and PE 4018 84803 56895 55750 27166 4340 57048 283871 9489 114971 780904 5091 23761 PMC7402324__F2 WNT Signaling in Melanoma 6010 998 4920 PMC7404279__F4 Depiction of a cancer cell motility and migration signaling network model that includes DEGs identified by RNA-seq analysis () as displaying upregulated genes in H 6010 2885 6714 998 PMC7408457__F2 Change in the profile of proteins and mRNAs of molecular factors in the primary tumor of the kidney and its metastatic sites 3630 5728 2475 PMC7413390__F5 Canonical pathway represented by differentially expressed proteins in the BALF between progressive and non-progressive sarcoidosis implementing Overlapping Canonical Pathway functionality in IPA 6010 998 940 PMC7417299__F5 Chemokine signaling pathway from KEGG has the highest counts for selected feature genes 126669 2885 572 387 1610 PMC7419519__F3 KEGG pathway mapping of CHO global spectral library 7095 11231 10956 258010 7353 100187907 581 83939 22926 596 7466 100506742 468 8454 9978 1874 9126 4087 4088 10274 10735 4089 545 472 2932 4193 6502 324 699 9184 991 5111 993 5347 983 1021 1019 1017 1022 990 8318 4661 999 1869 8317 10926 4998 4999 23595 5000 5001 23594 PMC7423983__F2 Roles of SIKs in the regulation of glucose, lipid metabolism and inflammation are illustrated 7099 3667 7189 23118 5105 355 3586 5183 PMC7426153__F5 Microbial Strategies for Survival in the Glass Sponge Vazella pourtalesii 444 2242 2695 2191 11113 100187907 65057 PMC7427859__F5 Differentially methylated genes of mTOR signaling pathway at CG (a) and CHH types (b) 2475 220441 83667 201163 64798 7249 6009 6010 5728 253260 3667 2887 6502 2932 1977 5163 6247 6446 PMC7430846__F6 Signaling pathways associated with cold acclimation of two carp species activated in the FoxO signaling pathway 901 23411 3479 3480 5728 664 3643 5163 5164 3630 7874 1956 2885 3156 9370 948 PMC7432699__F7 Schematic summary of the miR-targeting of RSU1 3611 6251 5728 1386 PMC7435111__F1 Scheme of the heme biosynthesis pathway and membrane transporters 5538 2235 9429 7390 5498 7389 PMC7442051__F2 Figure depicts the autophagy regulators in regard to lung injury 662 22863 1958 9474 9140 2475 10533 64422 9776 PMC7443482__F3 Biosynthesis, transport, and roles of the coenzyme thiamine diphosphate in the model plant Arabidopsis 7808 23413 5132 PMC7443512__F5 Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission 1636 59272 7113 PMC7457014__F5 Knockdown of DAP alters gene expression of the mTOR signaling pathway during proliferation of turkey satellite cells 7248 7249 6009 2475 1975 1977 6010 9776 8408 6194 1999 PMC7458396__F2 Cellular signalling pathways mediated by the constitutive activation of US28 6010 1499 3716 6774 2597 595 PMC7460249__F1 Metabolic reprogramming in cancer 355 948 3845 4609 95 619538 2806 PMC7460555__F1 PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/Beta-catenin pathways 627 4803 23621 4041 4040 5728 6247 2885 324 5163 7248 7249 6009 PMC7460646__F2 Inflammation contributes to leptin resistance in the brain at the hypothalamic arcuate nucleus, and as a result, alters food intake and energy expenditure leading to obesity 6774 23118 10454 5966 PMC7462086__F2 SOS1 Gain of Function Variants in Dilated Cardiomyopathy 6654 1431 673 5894 2885 5604 3082 PMC7463463__F1 Amino acid metabolic pathways altered in cancer and select inhibitors targeting these pathways 5058 5879 998 6303 125061 3398 196 PMC7464644__F3 Role of Tumor-Associated Myeloid Cells in Breast Cancer 6774 4318 383 PMC7465322__F7 Possible functional network of the AR induction pathway in sugarcane 578 59330 4609 PMC7467273__F2 Genome-wide analysis of DNA methylation in testis of male rat exposed to chlorpyrifos 7535 27040 4151 5447 5810 5339 4117 6010 572 351 PMC7471444__F5 Comparative pharmacogenomic analysis of three classic TCM prescriptions for coronary heart disease based on molecular network modeling 5360 4023 7350 3611 7316 364 PMC7472444__F5 Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase 1491 3939 3158 5105 216 445 443 384 PMC7473858__F8 Pathway modeling for genome signaling and metabolic reconstruction revealed the pathological mechanism of oral cancer using KEGG and Wiki pathway databases 100187761 581 5728 PMC7476772__F2 Immune Response to SARS-CoV2 & pharmacodynamics of rheumatology medications 324 3558 6774 4512 PMC7477886__F3 Simulated network from genetic variant to disease constructed from the insulin signaling pathway from KEGG 355 2308 2932 5163 5164 3643 7248 7249 572 6009 2475 1977 2885 2002 PMC7483535__F7 Long-term Changes in the Central Amygdala Proteome in Rats with a History of Chronic Cocaine Self-administration 4342 1398 6722 572 6714 7444 4772 1793 1977 369 PMC7484982__F3 Reign in the membrane: How common lipids govern mitochondrial function 4018 10390 10400 5091 55750 5662 283871 27166 132001 8760 1040 9489 56994 51012 56910 PMC7484992__F1 Signaling pathways activated by CXCR4 57007 6387 6714 2475 PMC7485553__F1 ACE and ACE2 in the pulmonary system and the tentative role of SARS-CoV-2The top right part of the figure shows the activation of the Spike (S)-protein of SARS-CoV-2 by predominantly TMPRSS2 and also other host proteases such as trypsin and furin 5045 59272 7113 1636 PMC7487481__F5 Metabolites, major metabolic pathways and pathway-related enzyme changes in palm oil-grown 5236 262 11113 PMC7487489__F7 MAPK signaling pathway 4351 2885 6722 5894 2316 1386 7124 8717 7186 2645 355 1616 4149 23118 929 51295 51701 PMC7491384__F3 Dietary Regulation of Immunity 4553 875 83939 114548 PMC7500008__F2 Targets of overexpressed (a) and downregulated (b) microRNAs (N1 versus N0) among genes participating cell cycle progression and regulation (KEGG pathway hsa04110 – cell cycle) 1311 4089 6502 5469 9184 699 5266 5111 1022 1017 1869 10926 4193 4661 PMC7511443__F4 MC5R signaling pathways 3717 6772 5346 PMC7521217__F10 Based on the findings from Figures  and , we summarized the proposed underlying mechanism of oxidative stress downstream signalling pathway participated in brain damage in setting of acute IS 4199 146956 735 581 PMC7522539__F1 Conceptual systems framework in NPDs (BD/SZ/MD), and lithium treatment amelioration of mitochondrial (mt) functions in distinct pathways 1499 4082 627 PMC7523953__F4 Comparative transcriptome analysis reveals candidate genes related to cadmium accumulation and tolerance in two almond mushroom (Agaricus brasiliensis) strains with contrasting cadmium tolerance 7358 47 4190 3240 11079 PMC7525161__F7 Identified key pathways 9081 3976 3240 790 4535 PMC7541823__F5 Pathway of phagosome biogenesis, maturation, and phagolysosome fusion for efficient clearance of Mtb 967 3916 8411 4074 83547 5524 80712 5879 382 8897 4905 8773 PMC7543703__F2 NSAIDs inhibit the synthesis of prostaglandins that protect against COVID-19 5226 4512 5228 PMC7546902__F4 Engineered biosynthetic pathway for geraniol in S 84232 3422 4553 3652 466 PMC7550790__F1 Involvement of unfolded protein response (UPR) in neuropsychiatric disorders 22926 83939 7494 627 PMC7552614__F10 Representation of the TGFB, BMP, and WNT signaling pathways 1499 2475 4089 PMC7554303__F2 Various cell fates upon Mycobacterium tuberculosis infection 7097 948 3553 8717 8772 PMC7556678__F1 Thromboinflammatory pathways in sickle cell disease 7450 3383 7099 7018 PMC7559203__F3 KSHV-deregulated NFKB signaling pathway in oncogenesis 6774 596 7852 2146 3662 27040 5879 PMC7560826__F3 Janus-like role of proline metabolism in cancer 468 6774 5625 2475 4942 PMC7561614__F1 Metabolic pathway for squalene synthesis in oleaginous yeast 4118 11113 4597 3652 PMC7564365__F6 Pilot Study on MicroRNA Profile in Tear Fluid to Predict Response to Anti-VEGF Treatments for Diabetic Macular Edema 10743 572 4513 2022 4087 4088 4086 PMC7566803__F7 IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells 472 3014 637 55775 23041 641 9656 3725 PMC7569177__F9 Cell Cycle Pathway from the KEGG Pathway hsa04110 5885 4089 2932 4193 6502 991 699 9184 5111 993 1017 1022 983 5347 999 1869 8317 4998 4999 5000 PMC7569438__F10 Molecular mechanism by which Guttiferone K exerts anti-inflammatory effects in Mtb-infected macrophages 7097 7099 4615 7189 4513 2475 114548 PMC7570440__F1 Major longevity pathways and longevity-associated transcription factors in C 5163 23411 207 208 6500 2475 7942 PMC7574589__F1 Scheme of mannose metabolism in MPI deficient cell 101448070 5236 351 2539 4351 5373 PMC7576747__F2 CIN via complex pathways of ROS from in vitro and in vivo studies 6010 847 6772 6667 23411 PMC7576747__F3 Intervention to reduce ROS for the prevention of CIN: evidence from in vitro, in vivo and clinical studies 23411 6010 1728 2475 PMC7577085__F2 Signaling pathways activated by MSP and RON 7099 22906 7189 2885 114548 7391 4261 PMC7586489__F1 Locations of DNA base lesions govern TNR instability through BER 2237 5423 4968 PMC7586489__F2 TNR expansions and deletions through BER 5423 2237 5111 PMC7591509__F4 Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis 5226 4963 246 239 6916 9536 240 4049 4050 PMC7592369__F1 Canonical and non-canonical regulation of HIF signaling 8453 2885 5728 2475 2056 595 405 PMC7594527__F1 Lipid metabolic pathway in S 4018 5132 6476 5091 PMC7599061__F1 Schematic process of the SARS-CoV-2’s internalization, proliferation in the cell, and influence on RAS 183 1636 59272 7113 847 PMC7599606__F2 An integrative view of glutamine metabolism 2744 3417 4118 2194 PMC7599810__F1 Molecular pathogenesis of SARS-CoV-2 1636 59272 114548 PMC7601465__F3 Transforming growth factorB signaling in a nutshell 7048 7046 998 2885 387 4092 4087 4089 PMC7603577__F9 Relaxin signaling pathway in the treatment of gout and hyperuricemia with plantain 4318 4313 7039 51289 PMC7606919__F1 Resistance to immunotherapy 114034 103 11201 567 7039 3620 3902 8205 151888 201633 PMC7609776__F4 KEGG AD pathway including Cd-associated transcripts in males 351 23385 3416 4023 348 572 8772 842 836 637 317 6622 100506742 7124 PMC7641965__F1 Integrating immunotherapy and targeted therapy in cancer treatment: mechanistic insights and clinical implications 324 941 3902 940 383 PMC7642048__F1 Mechanical stretch-induced signaling pathway in VSMCs 367 3480 6714 22926 9447 51564 100616389 100302155 23411 PMC7642714__F9 IL-17 signaling pathway 1878 8772 7054 23118 4513 9317 PMC7643595__F1 Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism 5697 885 5465 PMC7646253__F5 A3 activation of BER and MMR 2638 7374 2237 PMC7649776__F4 Psychiatric and cognitive SNPs mark eQTLs that are associated with gene expression within the neurotrophin signaling pathway 10818 1398 351 2885 4803 2549 126669 3667 572 387 7189 581 998 PMC7654839__F1 Optogenetic tools for remote activation of intracellular Ca2+ signaling 367 84876 790 4948 4827 6786 PMC7659517__F2 Schematic view of M1 and M2 macrophage metabolism.Left side, M1 macrophage triggers a pro-inflammatory response 948 47 2475 5163 3418 2744 467 PMC7662834__F7 Insulin signaling pathway 3630 3643 7249 7248 6009 572 PMC7665448__F2 SARS-CoV-2 infects the host through angiotensin-converting enzyme (ACE) 2 receptors which are elevated in inflammatory conditions 1401 90865 920 59272 PMC7672634__F1 Ingenuity pathway analysis of FGF/FGFR pathway suppressed by cordycepin in MA-10 cells 3082 2885 1398 3708 6774 9261 PMC7676939__F3 Androgen effects on the adrenergic system in the airway smooth muscle (ASM) 1312 339855 367 PMC7681028__F6 Functions and pathways of the type II MAGEs, MAGE-F1 and -L2 64210 5424 51750 2242 3953 9575 1407 51699 55737 54551 5987 7874 PMC7685798__F7 Reanalysis of 14 designated genes via KEGG pathway enrichment 9126 4193 6502 4609 699 5111 1017 1022 999 4998 4999 23595 5001 PMC7686704__F3 Wnt–Ca2+signaling pathway in mammals 6259 3643 57620 6786 998 1386 51701 1499 PMC7686857__F1 Mitochondrial iron co-factor biosynthetic pathways are reliant on FXN iron chaperone function 2235 23479 9054 PMC7688896__F2 Signaling pathways that regulate ADF/cofilin phosphorylation and dephosphorylation during LTP and LTD 1000 998 387 1499 3984 PMC7689244__F9 iTRAQ-based proteomics reveals serum protein changes in hypertensive rats induced by a high-salt diet 387 7408 3611 1499 5728 1398 126669 5894 572 PMC7691336__F9 Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling 6262 4776 2626 PMC7693003__F1 Biosynthesis of cholesterol and its derivatives 2222 5879 387 998 PMC7695009__F5 Overall view of HA roles in the cancer metabolic pathway 5208 8473 10724 5163 960 PMC7695717__F6 Oxytocin signalling network enriched in the analysis of the interaction of diet and n-3 PUFA supplementation in pregnant heifers 4513 8178 5020 1610 4975 1311 399 PMC7698460__F3 Recent strategies aimed at targeting TAMs in combination with ICIs for melanoma treatment 5281 7422 9332 383 PMC7699713__F2 Metabolic regulation of antioxidants: Highly proliferative cancer cells rely on glycolysis to meet its exceedingly high energy demands 57103 2539 3417 PMC7699985__F1 VEGFR-2 signaling and 4 types of anti-angiogenic agents 100187761 7422 6714 999 PMC7702664__F5 Visualization of KEGG pathway of the genes altered in the CUBN neighborhood in CRC 4354 759 4099 9227 PMC7708042__F4 DNA breakage formation induced by G4 stabilization 1763 6741 2237 PMC7711227__F2 CaMK, MAPK/ERK, and CaN Signaling From L-VSCCs to Transcription 23373 6722 150094 PMC7713123__F1 Pathway engineering in yeast for synthesizing the complex polyketide bikaverin 1178 7167 5230 6187 2026 PMC7716119__F4 Differentially expressed mRNA of the ceRNA network was significantly enriched, to create a meaningful MAPK and FoxO signaling pathway map 1610 4351 2002 695 4284 7939 1616 355 4149 929 23118 51295 51701 4089 1537 6502 4193 664 3479 5728 3630 3643 472 3569 1017 6774 10365 1950 PMC7716749__F1 Schematic diagram showing chondrocyte stages in the growth plate during development and selected signals that regulate these processes, including PTHrP, IHH, WNTs, FGFs, BMP and TGFB, IGF1 and IGF2 2539 2247 2597 650 3549 3479 3481 PMC7721156__F3 Interaction of preimplantation factor with the global bovine endometrial transcriptome 27040 472 613 6850 4067 7189 331 3929 4513 4049 4050 PMC7723926__F1 Schematic depiction of unfolded protein response (UPR) signaling cascade, and the interplay between endoplasmic reticulum (ER) stress response and inflammation 22926 83939 51493 4553 468 7494 406952 3569 10628 114548 PMC7726231__F3 Raptor silencing down-regulated components of mTORC1 (RPTOR, RPS15 A, RPS28) but not mTORC2 signaling in PHT cells 3643 5163 7248 7249 5091 6009 2475 1975 1977 6010 9776 8408 1999 PMC7730553__F8 When LPS binds to TLR4 in the cell membrane, the resulting complex can lead to the activation of adaptor proteins including MyD88 and TIR-domain-containing adapter-inducing interferonB (TRIF) 7099 4615 4513 3603 114609 PMC7731343__F7 Differentially expressed protein (DEP) expression in the plasma of rainbow trout exposed to thermal stress 718 3263 2244 60 PMC7753360__F2 Therapeutic targets and anticancer drugs within the lipid metabolism pathway 355 4023 948 7038 6319 47 2475 3156 3949 7436 PMC7758031__F1 Regulatory mechanisms of DELLA stability by PTMs 64326 9978 6500 8454 1642 PMC7761452__F2 Metazoan MOB proteins present extensive regulation between isotypes 51379 84859 57572 85440 81704 60485 4485 10979 9113 26524 5347 PMC7767264__F4 Representation of genes/pathways/transcription factors identified from host–pathogen interaction during aflatoxin production 4881 4602 2077 PMC7767525__F1 Summary of the activity of FANC proteins in the FA/BRCA pathway 545 91442 57697 3398 672 84464 51455 55159 7398 PMC7767754__F6 DDR pathway [, , ]: The DNA damage and response pathway: The figure depicts the causative agents and plausible DNA damage repair pathways 6741 8505 3014 472 545 993 PMC7771966__F1 Identification of UDP-glucose:glycoprotein glucosyltransferase (UGGT) 1/2 substrates 79087 10195 29929 84920 79868 56052 2519 56605 3479 5167 9353 4035 5352 3082 5351 PMC7772706__F3a Based on network pharmacology method to discovered the targets and therapeutic mechanism of Paederia scandens against nonalcoholic fatty liver disease in chicken 6667 5420 6668 6497 6420 5898 79026 83547 387 6395 54806 53366 4703 114609 4609 3553 7189 7975 100187907 2597 8717 840 8772 114548 4671 PMC7773908__F7 Positive crosstalk between epidermal growth factor receptor (EGFR) and the platelet-activating factor (PAF) pathway in cervical cancer cells 1956 5091 54947 PMC7781331__F2 WormPaths examples 268 5160 2203 3417 5105 5106 7167 2820 2819 5230 120114 2195 417 PMC7783549__F7 Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice 7124 355 8772 1616 7186 8213 9049 2152 468 572 637 100506742 4703 836 840 835 56616 27429 150365 387569 790 PMC7784881__F1 CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels 921 6850 613 4067 5336 2475 3586 PMC7792207__F4 Survivin and interaction with apoptotic pathways 10763 8772 331 54739 54623 PMC7795059__F1 Scheme illustrating the diverse autophagic pathways in cancer cells 8408 9706 9776 60673 64422 10533 83734 9140 PMC7795776__F5 Predicted relationship between expressed and regulated genes within integrin, paxillin, and RhoGDI signaling pathways, and the consequent activation of diseases and biological functions in elderly individuals with T2D 3611 5829 6010 7414 6714 9815 998 382 PMC7803379__F1 Non-redox cycling mechanisms of oxidative stress induced by PM metals 2597 57716 9817 1956 PMC7807149__F6 Lycopene Production Pathway in Triple KOE 57120 6120 5091 PMC7813762__F5 Representative metabolic pathway maps of differentially expressed proteins involved in TCA cycle (A) and proteasome (B) in KEGG 6185 6184 23237 PMC7816286__F6 Potential signaling pathway by which CD90 regulates biological behavior and energy metabolism in gastric cancer cells 5728 5163 22933 51548 23411 23410 4193 PMC7820188__F2 Wnt signaling, structure and activation: Wnt signaling is activated when glycoprotein ligands of the Wnt family bind Frizzled transmembrane receptors located at cell membrane level 6010 998 324 PMC7824032__F1 Methylglyoxal and methylglyoxal pathway in cell response to oxidative stress 2739 2597 4118 8011 PMC7824104__F2 Nrf2 signaling 9978 8452 9817 6500 4094 196 PMC7825104__F3 Adrenergic signalling pathway and mechanisms 673 572 6774 4485 9113 2475 3091 6591 PMC7825801__F3 Fatty acid metabolism 109703458 95 2194 1374 3033 PMC7836100__F2 Structural changes capture multiple regulatory events in yeast responding to osmotic shockA schematic of the yeast HOG-MAPK pathway and its links to glycolytic and glycerol biosynthesis pathways 2147 7167 2819 5230 2026 PMC7843791__F1 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer 57103 8789 2932 2203 5315 PMC7843791__F9 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer 759 847 4678 440 468 790 4810 5832 5625 PMC7849651__F6 Summary of the potential pathways about exogenous antigen 11S processing and presentation in the distal intestine 9049 920 978 2475 6009 7249 6010 121536 717 PMC7851123__F1 Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer 472 545 7808 2177 4264 55215 7515 4292 5395 641 79728 2067 5888 PMC7852140__F3 Metabolic pathway of norvancomycin biosynthesis up-regulated in high-yield strain 4118 11113 2733 PMC7862249__F1 Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities 9097 10533 9140 7189 4734 9474 83734 4077 8887 10133 64422 PMC7863132__F1 Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease 22926 23071 5350 90550 PMC7863132__F2 Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease 22926 5350 90550 581 PMC7865241__F7 Mechanistic scheme summarizing the anti-inflammatory effect of KMU-1170 7099 4615 114548 3553 PMC7865698__F1 Inflammation and cancer connection pathways 6774 4513 3553 8178 PMC7867275__F1 Heme synthesis pathway and mechanism of 5-aminolevulinic acid (5-ALA) fluorescence 1956 5498 9429 1371 4827 PMC7867633__F3 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes 367 6667 1956 6654 27343 11201 2885 PMC7868698__F2 Deep Look into the Program of Rapid Tumor Growth of Hepatocellular Carcinoma 5972 6476 27127 472 4609 5925 50975 4999 PMC7870784__F3 Depiction of the MAPK signaling pathway in the KEGG database 51701 6288 1616 PMC7872968__F6 IL-17 signaling pathway 5899 382 7189 84818 23765 PMC7872968__F8 RIG-I signaling pathway 79671 57506 7189 7186 7187 8717 8772 29110 3661 PMC7876385__F4 Novel strategies of drug resistance reversal in BCSCs 6469 50846 9429 6608 8772 51684 5728 253260 8139 596 1499 PMC7877093__F11 Five genes are indicated in red on the AGE–RAGE signaling pathway map after PGQYD treatment (red) 7038 183 6401 4313 3569 7018 581 1019 1958 PMC7877337__F3 Virulence factors and related effects in P 5879 4312 3553 PMC7878563__F5 Signaling pathways coupled to the M1 mAChR 156 387 2932 PMC7878744__F1 Renal metabolism and hypertension 95 5183 3158 1431 2744 PMC7880341__F5 NSCLC-pathway 5894 4513 842 5879 150365 7124 8717 3550 4049 PMC7881565__F6 Distinct pathway for internalisation of MSN, MWCNT, and ZnO NPs in CHO-K1 cells: The proposed mechanism involved MSN and ZnO NPs uptake through clathrin-mediated endocytosis 4478 2885 811 4361 8480 9475 472 545 1795 5879 203068 9140 1017 1021 1019 4074 8205 51699 594857 8897 PMC7890234__F1 Activation of unfolded protein response 22926 7186 83939 468 7494 581 PMC7903350__F5 Pathways related to hypothalamic-pituitary-gonads axis and targets of EIF 4117 4313 998 1839 5894 1958 3643 3949 9210 2492 654 PMC7905009__F3 Scheme representing the different regenerative processes promoted by TGFB/activin signaling 7043 7040 7042 4088 4087 4321 6657 10716 406935 406984 406937 7050 PMC7911844__F2 Biosynthetic pathway of the mcm5s2U modification 81605 9054 4553 PMC7915382__F1 Aldosterone signaling pathway most significantly affected by oregano with 19 genes 367 23463 1384 5163 4734 PMC7918477__F1 ER stress and unfolded protein response (UPR) signaling pathway 22926 83939 7494 468 PMC7920247__F1 PTEN and PI3K/Akt signaling pathway 1950 5163 5728 7249 7248 6009 PMC7921316__F3 Molecular mechanisms of natural polyphenols in colon cancer 1499 8772 3553 4513 PMC7923230__F2 ‘Signaling pathways regulating pluripotency of stem cells’ KEGG pathway 6657 6774 9241 3976 3977 4838 1852 4089 3725 652 324 5978 1878 3280 3670 PMC7923240__F8 De Novo Transcriptome Assembly of Two Microsorum Fern Species Identifies Enzymes Required for Two Upstream Pathways of Phytoecdysteroids 4598 4597 3652 1718 10682 1717 4397 PMC7926039__F2 Fibroblasts involved in the EPAC pathway and connection with fibrosis 4087 4088 6010 4089 5047 PMC7929421__F3 Immune response activation pathway 55384 7097 4615 51135 7187 50507 7189 29110 257397 10454 23118 3661 3665 105416157 PMC7930983__F3 Integrin-dependent adhesion and tensile force mechanotransduction modulate cellular behavior 387 998 5879 PMC7933442__F1 Hypothetical model showing how alpha1-antitrypsin (AAT) may affect staurosporine (STS)-induced apoptosis and autophagy in NSCLC cells 4035 412 2147 2475 790 9474 PMC7935738__F1 Hepatic bile acid metabolism 1581 1593 2264 PMC7940767__F2 Simplified overview of the cAMP/PKA/CREB pathway in the control of GH synthesis and secretion in somatotrophs 2691 2692 2695 PMC7940950__F2 Four genes (RAC2, CXCR4, CXCL2, and CCL18) were significantly enriched in the chemokine signaling pathway 126669 572 11079 1794 3702 387 1398 8314 PMC7947037__F2 Betaine and choline status modify the effect of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults 2548 2593 10400 5091 27232 635 4548 4397 6573 4524 PMC7948516__F1 Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing 4023 26035 6510 81539 7038 PMC7955048__F5 Direct catalytic asymmetric synthesis of Alpha-chiral bicyclo[1.1.1]pentanes 5091 126669 367 PMC7958858__F2 Signaling pathways involved in TJ formation and modulation 2885 1956 929 387 51135 3654 7189 5970 1386 PMC7959398__F7 Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection 1493 3932 962 867 916 2534 952 27040 3702 2885 7124 1019 8915 1610 29851 PMC7967251__F4 Potential signaling interactions between LPA and p53 in transformed cells 4018 51205 688 4193 PMC7969609__F9 MAPK signaling pathway 1610 4351 2002 6722 2444 5894 4284 2316 7124 8717 7186 4615 355 4149 4208 1616 929 23118 51295 51701 PMC7980187__F9 Possible signaling pathways utilized by SARS-CoV-2 for cellular hijacking 59272 6714 3932 3055 3702 5879 5266 3661 6010 847 2885 PMC7981362__F1 Insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease 3667 3416 2475 PMC7981362__F2 Insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer’s disease 3667 2475 7249 7248 PMC7981372__F5 Exploring the role of Azadirachta indica (neem) and its active compounds in the regulation of biological pathways: an update on molecular approach 5111 4318 581 596 PMC7985675__F2 Retortamonads from vertebrate hosts share features of anaerobic metabolism and pre-adaptations to parasitism with diplomonads 9049 2242 83876 5066 7018 PMC7988780__F3 Is nuclear sirtuin SIRT6 a master regulator of immune function? 6510 2744 4609 51548 PMC7991804__F2 An overview of mechanisms of GC resistance in ALL and pharmacological strategies to overcome it 2322 2638 596 5728 2475 8205 6446 3280 64109 2908 PMC7993417__F5 Phenotypic diversity and metabolic specialization of renal endothelial cells 9314 10365 3037 23411 7019 4018 1902 50507 5163 PMC7995014__F1 Schematic illustration depicting the association of overnutrition/obesity/excess amino acids to angiotensin‐converting enzyme (ACE2) receptors leading to the hyperactivation of mammalian target of rapamycin (mTOR) 59272 4553 2475 PMC8000072__F6 Proposed pathway by which SCFAs regulate lipid metabolism in a sex-specific manner in Long–Evans rats 1581 39 7038 1071 PMC8001969__F4 MTOR signaling pathway and its important regulatory functions are shown 3667 7248 6009 5163 64798 9675 7942 8408 6446 PMC8004226__F6 Network of putative senolytic compounds with their biological targets 5777 43 5888 3725 3066 PMC8004491__F1 Two pathways that collect and deliver axonal cargo for degradation in lysosomes 10533 9474 9140 55054 PMC8005514__F4 PI3K/AKT pathway is related to chemotherapy, CDK4/6 and PARP inhibitor resistance 6741 2932 2475 5728 6714 9817 1019 1021 7808 PMC8009859__F1 Illustration of proposed MB related proteins/pathways described in this review. (i) Conventional MB-related signaling pathways 2475 2932 324 1499 7465 5144 6714 6608 51684 6667 PMC8011202__F1 Insulin and pharmacological agents on endothelial insulin signaling 2885 1803 2695 PMC8012622__F5 Formation pathway of cytoskeleton structure by F-actin 998 5879 387 6010 PMC8014416__F6 KEGG pathway analysis on three up-regulated DEGs 2475 5879 613 930 5934 5728 6256 4089 285704 3458 7124 79875 8454 6500 1616 PMC8016657__F2 Roles of Epac in synaptic plasticity, neurodevelopment, and cell death 5912 2475 673 PMC8019794__F3 Macroautophagy pathway and signaling 2475 9776 8408 9140 22863 10533 83734 9474 23192 55054 64422 PMC8020258__F6 Osthole inhibits macrophage activation in an experimental model of asthma (schematic) 3565 4282 383 PMC8020906__F5 Interplay between HBP, mTOR, and AMPK signaling pathways 5728 8473 5163 7249 7248 6009 2997 2998 8408 PMC8022952__F1 Expected flavonoid biosynthesis pathway in maize 717 53366 7911 PMC8023278__F10 Estrogen signaling pathway ranked first in Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment terms 9166 3880 1509 7031 5241 7039 2885 759 PMC8024479__F3 Intrinsic apoptotic pathway 581 637 56616 27429 2021 7186 22926 4193 83939 468 56848 PMC8027424__F1 Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping 6120 7086 5447 1431 2271 PMC8035038__F8 Potential molecular mechanism of anticancer effects of SLT on ovarian cancer 581 595 1019 1000 999 PMC8036789__F4a Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs 100187761 7099 6387 6376 4513 5226 4803 22906 PMC8036963__F3 DNA damage response (DDR) pathway involves sensor, transducer, mediator/amplifier, and effector proteins, which act following the induction of a DNA lesion or replication stress 3014 472 84126 545 7518 PMC8037268__F17 Signaling pathways affected by hSDC1 overexpression in DEN-induced hepatocarcinogenesis 6382 1839 1956 3643 558 5163 324 64798 1499 1977 5966 595 PMC8037590__F1 PI3K and MAPK signalling pathways 5163 5728 253260 2475 64798 2885 7248 7249 6009 581 4193 572 8085 6194 1977 PMC8038160__F2 Flavonoids modulate inflammation and immunity pathways in cancer 7099 3717 8717 7186 7188 7189 114548 6714 8195 6774 5212 4313 4318 PMC8038160__F4 Flavonoids modulate growth pathways in cancer 1950 1956 5728 2885 5212 7249 6009 64798 2475 27250 29904 1938 PMC8041881__F4 IL-17 signaling pathway 8178 8717 8772 3565 5966 4703 7187 100187907 3934 4322 6420 29761 8205 PMC8044534__F2 Diverse range of signals in the TME which could induce HMOX1 expression 9817 6774 571 PMC8047423__F2 Molecular mechanism governing cell quiescence and torpidity in contrast with cell proliferation and euthermia 5728 7248 5166 5164 2475 5371 7018 4211 10533 PMC8050425__F5 Can1 and Mup1 endocytic pathways triggered by distinct signals 4163 4046 4881 PMC8054189__F1 Aminoglycerophospholipid biosynthetic pathways in yeast, Saccharomyces cerevisiae 84249 5091 1040 PMC8056114__F1 NGF-mediated regulation of the NGFR and NTRK1 signaling pathways 4803 4804 4914 1378 122769 1380 84894 6010 2549 PMC8059808__F2 Boolean module is a dynamic module including Snf1, PKA, and TOR pathway as well as crosstalk between them 1611 6402 22944 8213 PMC8071006__F6 Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model 113174 1506 7462 PMC8071014__F2 Glucose and lipid metabolism in TAMs 6778 948 5163 383 11343 PMC8071039__F4 Signaling pathway and cell migration 6010 1499 55364 PMC8074257__F4 Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers 2638 7249 7248 5728 5163 6194 PMC8082181__F10 Trilobatin, a Component from Lithocarpus polystachyrus Rehd., Increases Longevity in C. elegans Through Activating SKN1/SIRT3/DAF16 Signaling Pathway 847 6648 23410 6649 PMC8082393__F8 Comprehensive RNA-Seq Analysis of Potential Therapeutic Targets of Gan–Dou–Fu–Mu Decoction for Treatment of Wilson Disease Using a Toxic Milk Mouse Model 126669 335 5360 4023 3611 7316 4312 1376 PMC8083963__F1 Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease 81609 8724 79971 1956 PMC8089133__F4 Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study 4232 961 5447 7851 29110 8772 7186 23118 257397 4513 7124 145553 PMC8102268__F4 Study of the differential expression profiles of Keshan disease lncRNA/mRNA genes based on RNA-seq 3630 5728 51701 2444 6502 1039 4089 10365 472 PMC8102306__F1 Intrinsic drivers of metabolic pathways 2885 4609 3156 5728 5163 3098 6510 2023 6009 7249 7248 PMC8104092__F6 G-Protein-Coupled Receptor and Ion Channel Genes Used by Influenza Virus for Replication 2002 5997 3055 6714 PMC8105803__F7 Map of p53 signaling pathway regulated by LEP gene drawn through the KEGG database 7249 7099 613 6850 5728 572 PMC8110832__F1 Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer 3099 2597 1956 5105 1499 PMC8110832__F3 Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer 2539 160728 4208 23411 10135 PMC8112849__F3 Melanogenesis signalling pathways 4157 4286 1499 PMC8113818__F2 Unfolded protein response (UPR), autophagy and coronavirus (CoV) infections 22863 22926 9474 PMC8115630__F6 Relative abundance of respective enzymes involved in central carbon metabolic pathways in “Ca. B. sinica” based on proteomeic analysis 5226 7086 5183 6120 5091 2539 2597 2821 6390 6389 4397 3417 PMC8116547__F1 miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection 4049 4050 4512 3932 PMC8117345__F5 DNA Repair Repertoire of the Enigmatic Hydra 1643 1642 7508 2067 7507 PMC8120650__F5 Autophagy-related signaling pathways are involved in cancer (Review) 596 998 1950 83939 468 3916 3920 9817 4513 9474 PMC8125073__F7 Oral Epithelial Cells Distinguish between Candida Species with High or Low Pathogenic Potential through MicroRNA Regulation 183 3953 4284 4118 7150 4067 5972 4087 4088 29949 1889 581 PMC8132124__F3 Surviving the odds: From perception to survival of fungal phytopathogens under host-generated oxidative burst 472 6647 10413 6723 PMC8132131__F4 Interplay between hydrogen sulfide and other signaling molecules in the regulation of guard cell signaling and abiotic/biotic stress response 22944 340451 847 PMC8136793__F1 Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication 5888 1652 201973 PMC8137523__F5 Prenyltransferase biology is key to identifying targets of statin anti-cancer effects 2339 2342 6010 5875 5876 375743 25827 6500 PMC8137995__F4 Modeling the Th17 and Tregs Paradigm: Implications for Cancer Immunotherapy 3702 50943 2475 2197 149233 PMC8138161__F3 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway 355 8772 581 2475 8408 9706 9776 2147 PMC8139523__F2 Take a Walk to the Wild Side of Caenorhabditis elegans-Pathogen Interactions 7018 5163 208 207 6446 PMC8141399__F1 Banxia Xiexin Decoction Inhibits the Expression of PD-L1 Through Multi-Target and Multi-Pathway Regulation of Major Oncogenes in Gastric Cancer 1950 3458 1956 114609 4615 5728 7189 2475 PMC8143176__F1 Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer 9759 6722 2113 3297 1385 PMC8144931__F5 Next-generation sequencing analysis reveals that MTH-3, a novel curcuminoid derivative, suppresses the invasion of MDA-MB-231 triple-negative breast adenocarcinoma cells 613 930 6850 5879 5728 5163 7249 5894 572 4193 51083 5934 84188 150365 PMC8146703__F6 Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study 355 4099 6319 5091 100187761 1431 PMC8148450__F5 Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways 1537 673 5728 545 790 3725 4118 27040 PMC8151052__F1 Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer 2885 10818 2549 867 PMC8152462__F4 Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs 7124 1386 6772 4149 4609 466 6722 PMC8155968__F1 Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities 472 545 596 581 2475 PMC8157222__F1 Lessons from Comparison of Hypoxia Signaling in Plants and Mammals 11101 5999 84890 197131 7428 3091 PMC8157222__F2 Lessons from Comparison of Hypoxia Signaling in Plants and Mammals 64326 11101 2077 5212 197131 PMC8160027__F3 Vital role for nitric oxide in intraocular pressure homeostasis 857 9780 1003 1499 6714 5175 PMC8160634__F2 Potential Role for HUWE1 in Modulating Cisplatin Sensitivity 990 545 11073 5423 10075 PMC8161999__F6 Identification of circRNA–miRNA–mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer 5426 6476 355 920 930 6850 5091 8717 1610 1616 351 57136 3240 7249 572 4703 4149 7975 5934 10682 150365 4602 PMC8163614__F1 B2-Adrenergic receptor agonism as a therapeutic strategy for kidney disease 4280 367 9927 55669 PMC8167159__F2 Strategies to tackle RAS-mutated metastatic colorectal cancer 5728 2475 4193 1950 1956 1021 1019 961 PMC8169406__F5 Strategies to restore NO bioactivity 59272 1636 2638 PMC8170118__F3 Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data 2353 7791 7414 81 7094 595 596 351 PMC8171523__F1 Wnt信号通路对软骨和软骨下骨双靶向调控及其在骨关节炎进展中的作用 1499 324 6010 PMC8173139__F1 Radiotherapy and Cytokine Storm: Risk and Mechanism 58191 6352 54106 2357 7852 114548 3458 PMC8175775__F6 Identification of Tumor Necrosis Factor-Alpha (TNFA) Inhibitor in Rheumatoid Arthritis Using Network Pharmacology and Molecular Docking 7124 8717 8772 6651 PMC8176240__F6 Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression 4089 6774 572 842 675 5888 581 51426 PMC8178780__F1 Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation 7099 1380 6774 3717 PMC8183764__F1 Fructose and metabolic diseases: too much to be good 2645 5313 26007 3795 229 2194 PMC8185021__F6 Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation 1431 4313 4318 4323 7249 7248 6009 6382 PMC8192490__F3 miR-940 is a new biomarker with tumor diagnostic and prognostic value 1499 595 4316 6774 1019 581 PMC8194072__F1 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration 1950 7852 2475 6010 PMC8195768__F2 Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer 1499 998 8195 92610 PMC8198168__F1 Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer 3939 23028 2744 355 PMC8200290__F1 Up-regulated genes in basal cell carcinoma compared with normal skin, overlaid on the KEGG “Pathways in Cancer” pathway 4099 1399 324 8453 9365 4118 PMC8200410__F6 Ketogenic Metabolic Therapy, Without Chemo or Radiation, for the Long-Term Management of IDH1-Mutant Glioblastoma: An 80-Month Follow-Up Case Report 6098 5019 3939 2806 PMC8201612__F3 Amino Acid Trafficking and Skeletal Muscle Protein Synthesis: A Case of Supply and Demand 7249 7248 6009 64798 2475 1998 1977 2147 PMC8203678__F5 Genome-wide portrait of pervasive drug contaminants 384 1358 1357 383 PMC8204050__F7 Key Macrophage Responses to Infection With Mycobacterium tuberculosis Are Co-Regulated by microRNAs and DNA Methylation 3630 1080 948 2147 7249 23411 25886 6009 355 1537 PMC8204760__F3 Non-G-protein signaling at 5-HT receptors 6714 1020 998 351 PMC8204760__F4 Constitutive activation of 5-HT6 receptors by different GPCR-interacting proteins (GIPs) 2695 4763 2475 1020 998 PMC8207264__F6 Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8− Positive (AT8+) Tau in Alzheimer’s Disease 6648 11113 2593 2628 435 5009 4552 4524 4397 PMC8213678__F8 Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer 3717 2645 5810 4703 7054 5618 PMC8217552__F4 Autophagy induction limits SARS-CoV-2 growth in vitro 7942 9474 9140 10533 1984 207 2033 6502 8678 8408 PMC8220449__F7 Schematic diagram depicting the effect of TMJ-12 on the PI3K/AKT signaling pathway leading to the induction of apoptosis and cell cycle arrest in BPH-1 cells 1977 2475 5728 5163 572 581 PMC8222328__F2 Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction 162239 1325 2744 790 472 PMC8222468__F2 Extracellular vesicles in podocyte autophagy in kidney disease 5371 6009 7248 29904 7249 9776 1938 64223 2475 5728 22863 664 PMC8227118__F7 Genome-Wide Differential Methylation Profiles from Two Terpene-Rich Medicinal Plant Extracts Administered in Osteoarthritis Rats 613 930 5879 5341 5266 5728 5163 951 7249 5894 6009 572 4193 2475 2000 PMC8228377__F1 Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses 6923 6921 28958 PMC8229353__F2 Opposed Interplay between IDH1 Mutations and the WNT/Beta-Catenin Pathway: Added Information for Glioma Classification 3939 5300 324 1499 PMC8230057__F1 How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System 4928 8480 29107 10482 23636 3661 8021 3843 717 9972 1356 11052 5901 1958 10527 PMC8230717__F2 Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study 3630 100188776 1537 51701 1017 PMC8230743__F12 Gene Expression Profile and Co-Expression Network of Pearl Gentian Grouper under Cold Stress by Integrating Illumina and PacBio Sequences 3479 3643 3630 1080 948 2147 51701 6502 4193 5914 1017 7249 25886 6009 355 664 9140 472 PMC8230743__F13 Gene Expression Profile and Co-Expression Network of Pearl Gentian Grouper under Cold Stress by Integrating Illumina and PacBio Sequences 3630 3643 2695 108 5836 5211 5140 2147 2475 5066 7249 6009 5315 11113 200186 572 1977 23411 95 5225 355 PMC8231629__F3 Impact of Hydrogen Peroxide on Protein Synthesis in Yeast 1977 1975 83939 PMC8231959__F1 Coenzyme Q Biosynthesis: An Update on the Origins of the Benzenoid Ring and Discovery of New Ring Precursors 27235 51004 6010 51805 3652 84274 10229 2230 112812 2232 PMC8233504__F7 Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila 10273 8562 11140 8454 5163 6009 25843 7248 3416 253260 207 2332 4609 PMC8234716__F2 Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives 5728 5163 6772 6774 3606 PMC8234716__F3 Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives 4513 114548 7412 3383 PMC8234951__F3 Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer 2475 581 6774 1499 PMC8234993__F4 Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq. 613 930 2022 51074 5728 572 4193 6009 4703 5934 1537 PMC8236109__F1 Simulating ATO Mechanism and EGFR Signaling with Fuzzy Logic and Petri Net 1956 672 675 3065 6667 2305 993 990 PMC8236548__F1 Other side of the coin: dissecting molecular mechanisms behind hereditary breast cancer in search of therapeutic opportunities 1017 10111 472 4361 79728 545 675 PMC8236857__F3 Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead 4613 2194 3156 1969 3598 PMC8237755__F1 WIP, YAP/TAZ and Actin Connections Orchestrate Development and Transformation in the Central Nervous System 4609 595 51083 253260 6714 1950 2885 PMC8238154__F5 CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells 3458 7039 5155 PMC8238218__F4 Up- and down-regulated DEGs in the adenosine 3’,5’-cyclic monophosphate (cAMP) signaling pathway (map04024) between female control versus female DXM treated (FcVSFt) 7432 2695 4852 6651 6236 673 6662 268 6402 PMC8238251__F1 Endogenous AGE formation and pathobiological actions of RAGE receptor ligands 5091 3146 3717 3716 PMC8247262__F5 Metabolic model of Lipomyces starkeyi for predicting lipogenesis potential from diverse low-cost substrates 4118 115209 11113 PMC8250151__F1 Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19 729230 6347 6354 3717 383 2475 PMC8254267__F2 Gut microbiota-mediated immunomodulation in tumor 10663 7099 58191 5734 4049 4513 50943 4615 PMC8263212__F1 Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad 324 6772 383 6774 PMC8267940__F4 Instruction of Immunometabolism by Adipose Tissue: Implications for Cancer Progression 2475 383 355 PMC8268847__F3 MRNA Translation by Hormone Receptors in Breast and Prostate Cancer 83939 1999 29904 55140 91801 348180 90353 4553 PMC8268912__F1 Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment 5728 6009 7249 4763 7248 8408 9681 1977 PMC8282090__F8 KEGG pathways regulated by GPA2 or ASC1 as determined by sensitivity analysis 101927953 84135 51096 55272 92856 5822 PMC8282181__F3 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum 2885 867 2475 2308 PMC8282181__F4 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum 2885 998 7124 7186 PMC8284093__F7 Genomic Response to TGFB1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney 4092 4086 10207 166824 154796 4089 324 2712 174 8313 1490 PMC8285010__F2 Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARG in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol 9227 6120 54884 10901 1543 1579 PMC8285047__F2 Nitric oxide in orthodontic tooth movement (Review) 1499 4513 6714 PMC8286839__F14 Recruitment of repressors leads to termination of transcriptional responses 51701 3550 10370 1401 PMC8292061__F5 Exploring the Mechanism of Scutellaria baicalensis Georgi Efficacy against Oral Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking Analysis 100187761 3551 7015 238 2147 3815 2100 1956 983 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Prostate Cancer 5728 1956 5163 208 1147 1385 1026 367 10000 842 572 4193 2475 4318 4792 1387 1499 1027 PMC8307395__F3 Two-Pore Channels Regulate Expression of Various Receptors and Their Pathway-Related Proteins in Multiple Ways 7818 6093 1380 998 4781 3265 4117 PMC8308893__F6 Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice 383 54209 23621 1020 2932 PMC8309156__F1 Behind the Adaptive and Resistance Mechanisms of Cancer Stem Cells to TRAIL 64240 581 637 8772 PMC8310668__F9 Proposed schema of AZ, SFN, and AZ+SFN targeting the pro-survival pathways in BC 9817 5091 2810 PMC8319688__F4 Combining Genome-Wide Gene Expression Analysis (RNA-seq) and a Gene Editing Platform (CRISPR-Cas9) to Uncover the Selectively Pro-oxidant Activity of Aurone Compounds Against Candida albicans 27010 5105 7167 55276 2820 2734 127 128 192668 PMC8324686__F1 Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD) 55737 53917 3949 100187761 10577 4218 4864 57476 79102 PMC8341163__F4 CBE outcomes in gDNA 3978 11113 5426 353497 51426 51455 5111 PMC8346982__F3 Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment 1191 4035 6935 PMC8347150__F3 Impact of Hypoxia over Human Viral Infections and Key Cellular Processes 4799 2475 6010 PMC8348432__F8 Trans-(−)-Kusunokinin: A Potential Anticancer Lignan Compound against HER2 in Breast Cancer Cell Lines? 5898 1021 1019 595 891 PMC8348676__F2 Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis 355 581 83939 PMC8349014__F1 Flavonoids on diabetic nephropathy: advances and therapeutic opportunities 581 6009 2475 PMC8358715__F2 Hypoxia‐inducible factor‐1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases 50943 196 6775 PMC8358777__F7 Exploring the Pharmacological Mechanism of Radix Salvia Miltiorrhizae in the Treatment of Radiation Pneumonia by Using Network Pharmacology 51083 930 4117 7054 8772 572 6256 5934 351 4199 PMC8360179__F5 Plastidial acyl carrier protein Δ9‐desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum 95 1674 4018 5091 PMC8373118__F4 Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative 57506 3661 3665 7187 4615 PMC8377203__F2 Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids 672 472 286257 545 84126 11073 3014 PMC8377544__F5 Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man 5728 7249 7248 2309 50507 23411 6722 7351 PMC8389290__F7 Uncovering Mechanisms of Zanthoxylum piperitum Fruits for the Alleviation of Rheumatoid Arthritis Based on Network Pharmacology 7124 1950 1610 1616 4117 256933 4149 335 5360 4312 7350 3611 7316 364 PMC8389414__F2 LM pathway analysis identifies an upregulation in ALOX5 activity in patients with severe disease 2948 7432 5730 9536 PMC8389414__F5 LM pathway analysis highlights upregulation of AA-derived LM in non-survivors patients 7432 2948 9536 4050 PMC8392691__F2 Renin–Angiotensin System in the Tumor Microenvironment of Glioblastoma 59272 1499 8313 545 2475 PMC8394119__F1 NAD+ Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis 23411 3458 6647 847 23410 6648 PMC8395751__F10 Expression Profile of Genes Encoding Proteins Involved in Regulation of Vasculature Development and Heart Muscle Morphogenesis—A Transcriptomic Approach Based on a Porcine Model 100653366 5091 324 2669 1852 9118 6651 6657 220134 55183 9421 PMC83966__F7 Ras effector pathways in NGF stimulated PC12 cells 4803 5266 998 PMC8399174__F1 H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans 5257 8775 998 387 116844 PMC8399569__F5 Plant Salicylic Acid Signalling Pathway Regulates the Infection of a Biotrophic Pathogen in Grasses Associated with an Epichloë Endophyte 8161 4609 5337 8639 PMC8400885__F10 Benzoic Acid and Its Hydroxylated Derivatives Suppress Early Blight of Tomato (Alternaria solani) via the Induction of Salicylic Acid Biosynthesis and Enzymatic and Nonenzymatic Antioxidant Defense Machinery 847 5640 4881 PMC8402745__F2 Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development Challenges 59272 7113 847 1803 PMC8406487__F4 6‐Shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species 7124 4803 8772 7186 4703 56616 835 790 8739 PMC8413298__F9 Many gCIS function on the same pathway as the oncogenic driver responsible for tumor initiation 8805 51366 2549 10603 25970 4193 9021 23429 3082 3791 1387 6670 3717 9846 5515 9655 960 5295 4117 2885 4026 2132 9113 999 6009 PMC8418449__F6 Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease 2147 2539 6510 3156 2597 1719 387 PMC8421236__F2 Daily Rice Bran Consumption for 6 Months Influences Serum Glucagon-Like Peptide 2 and Metabolite Profiles without Differences in Trace Elements and Heavy Metals in Weaning Nicaraguan Infants at 12 Months of Age 5091 10486 95 PMC8421901__F3 Underlying mechanism of sorafenib resistance in hepatocellular carcinoma: a bioinformatics study based on validated resistance-related genes 9365 5901 351 4118 4149 1311 260402 PMC8422786__F2 Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy 54894 84133 324 1499 PMC8425214__F1 Regulatory networks of the Hippo signaling pathway in cancer development 6761 9113 60485 4485 26524 PMC8425214__F2 Regulatory networks of the Hippo signaling pathway in cancer development 154796 468 6477 6478 6761 60485 9113 6010 8239 PMC8434408__F3 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells 3980 252969 55247 4099 8930 4353 6996 5111 5426 3978 2237 PMC8434408__F4 Nanoparticle-Encapsulated Camptothecin: Epigenetic Modulation in DNA Repair Mechanisms in Colon Cancer Cells 6741 5978 5888 641 146956 79594 5893 10111 672 472 79728 675 50511 PMC8435254__F2 Serum L‐arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case‐control study 7432 50846 847 PMC8435626__F8 Integrated Phytochemical Analysis Based on UPLC–MS/MS and Network Pharmacology Approaches to Explore the Effect of Odontites vulgaris Moench on Rheumatoid Arthritis 6850 351 595 PMC8443079__F2 Regulation of renin in the collecting ducts 359 1636 183 5972 551 4513 PMC8447736__F4 Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 4117 8178 7124 8772 836 4311 4314 6401 6651 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Potential Biomarkers in Breast Cancer: A Comprehensive Bioinformatics Analysis 324 545 472 1325 991 1311 6502 PMC8472694__F2 Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism 5091 10400 9927 55669 10936 5662 90550 PMC8473084__F4 Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) Promotes M1 Repolarization of Porcine Alveolar Macrophages and Th1 Type Response 27040 23440 8205 5291 2146 8726 121536 PMC8480435__F2 Example of oncogenic signaling and downstream metabolic and physiologic imaging changes during molecular therapies 5728 5163 7248 7249 6009 1977 4609 PMC8486596__F2 Cellular senescence in cancer: from mechanisms to detection 545 472 1029 4193 983 1017 2475 1021 1019 4609 PMC8487426__F4 Alcohol use disorder (AUD)-associated miRNA–mRNA regulatory networks in the amygdala (AMY), the caudate nucleus (CN), the cerebellum (CRB), and the hippocampus (HIP) of AUD subjects (the Set 1 sample) 100422932 170692 7057 143425 3162 1356 100616338 102465858 100616239 9118 PMC8489124__F5 Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3B/Beta-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway 7455 351 1537 PMC8495393__F8 FGF7-induced E11 facilitates cell-cell communication through connexin43 2885 2549 2252 998 10630 2697 PMC8495593__F1 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers 6469 6608 1499 4040 PMC8497485__F3 Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer 2475 6774 3394 3716 6772 3553 4615 6778 383 PMC8500332__F8 n-butyrate alters the RAP1 signaling pathway in the endometriotic epithelial cells 27040 5810 790 PMC8505556__F2 Tumour suppressor functions of BAP1, Merlin and p16INK4a/p14ARF proteins 8314 9055 672 675 5893 4485 9113 26524 4609 1019 581 PMC8507042__F1 Metabolic reprogramming in epithelial ovarian cancer 3099 2597 5209 5230 5236 6774 26227 2147 PMC8509322__F3 Adaptive Mechanisms of Halophytes and Their Potential in Improving Salinity Tolerance in Plants 6654 847 6655 1178 PMC8509327__SF3 Non-Canonical Wnt Signalling Pathways in Bone Biology 4920 23118 387 7189 4040 4041 51701 1499 2475 1386 PMC8513137__F4 Glucagon’s Metabolic Action in Health and Disease 2642 23235 200186 5105 95 PMC8517511__F2 CBX7 is Dualistic in Cancer Progression Based on its Function and Molecular Interactions 23492 324 2146 3720 3066 999 648 PMC8523029__F1 12(S)-HETE/GPR31 Signaling Pathways 2853 7018 6010 PMC8524389__F4 Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial 7054 351 920 PMC8526852__F1 Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants 3661 1674 4342 PMC8527165__F2 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward 7462 196 2859 761 405 84890 367 PMC8527165__F3 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward 952 367 196 PMC8529605__F5 Mechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking 3939 671 1610 5163 5447 7428 29984 8453 2056 2091 5211 PMC8530873__F1a Stress stimulus produces a physiological response which involves the central nervous system (CNS) and the periphery 150094 23235 23387 1843 1958 1030 672 5888 545 472 PMC8533761__F1 Impairments in Brain Bioenergetics in Aging and Tau Pathology: A Chicken and Egg Situation? 2147 5209 5166 PMC8536488__F1 Cancer and Covid-19: Collectively catastrophic 6774 7186 8717 8772 PMC8539290__F2 Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids 4321 581 842 1652 7186 3383 7412 56954 PMC8540239__F3 An Insight into Anti-Inflammatory Activities and Inflammation Related Diseases of Anthocyanins: A Review of Both In Vivo and In Vitro Investigations 3929 114609 54472 7189 8195 929 PMC8544255__F1 Deregulation of the canonical MAPK signalling pathway during CRC treatment 3845 673 22944 4609 2002 6772 2885 5163 6198 998 3725 1386 1432 PMC8549280__F1 SREBP (Sterol Regulatory Element-Binding Protein) pathway: a regulatory bridge between carotenogenesis and sterol biosynthesis in the carotenogenic yeast Xanthophyllomyces dendrorhous 3652 4598 4597 PMC8550922__AF1 Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway 1571 22944 998 27161 PMC8551477__F4 Insulin action at a molecular level – 100 years of progress 3630 23216 867 2885 5140 2642 1652 7038 PMC8555053__F4 On the role of dauer in the adaptation of nematodes to a parasitic lifestyle 54704 9798 3479 5163 207 208 6446 9437 PMC8566343__F10 Comprehensive Proteome and Acetyl-Proteome Atlas Reveals Molecular Mechanisms Adapting to the Physiological Changes From Pre-laying to Peak-Laying Stage in Liver of Hens (Gallus gallus) 100 51166 3030 1962 3033 759 339855 790 6342 2147 367 7939 27068 54677 PMC8569819__F8 TNF signaling Kegg Pathway report for up-regulated DEGS caused by WYE (Low) 15 μg/ml vs. untreated controls after meeting selection criteria; -2+2 fold change, p-Value <0.05 and FDR p-Value <0.05. Up-regulated DEGS are demarcated by a red star 7124 8772 83737 759 23152 4099 1906 PMC8574228__F1 Signalling pathways in cardiac hypertrophy 5350 7220 7225 7222 3667 759 23410 367 857 6010 25801 5997 5999 1267 5152 1977 5163 2475 PMC8574228__F5 Metabolic flexibility and HFpEF 4023 948 95 847 23411 PMC8576031__F3 Therapeutic vulnerabilities and regulation of SLFN11-mediated cell death 2145 91607 545 7317 3458 PMC8579187__F1 Renin–angiotensin system 1636 59272 5547 PMC8582450__F10 Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer 6714 1314 5879 5058 PMC8582810__F7 Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer 56616 581 2021 150365 PMC8584016__F1 Systemic Review: Ozone: A Potential New Chemotherapy 9817 847 1728 PMC8588554__F7 Diterpenoid Compounds Isolated from Chloranthus oldhamii Solms Exert Anti-Inflammatory Effects by Inhibiting the IKK/NFKB Pathway 3929 929 7189 5091 4615 7099 8195 PMC8590693__F7 Hypothetical model illustrating multiple actions of NCT-58 on cancer stem-like properties, HER2 signaling, and trastuzumab resistance in HER2-positive breast cancer 3297 960 79923 PMC8601163__F1 Auxin‐mediated induction of GAL promoters by conditional degradation of Mig1p improves sesquiterpene production in Saccharomyces cerevisiae with engineered acetyl‐CoA synthesis 2819 51083 3652 PMC8602812__F3 Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites 9332 47 941 942 790 PMC8603508__F1 Noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways 29102 8205 103 54487 7018 PMC8615799__F9 Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma 3082 5328 960 5091 847 171177 998 PMC8616208__F2 Metabolic Control of Myeloid Cells in the Tumor Microenvironment 27035 383 8205 47 948 196 6774 7038 9817 4513 PMC8616527__F3 Willin/FRMD6: A Multi-Functional Neuronal Protein Associated with Alzheimer’s Disease 122786 5447 6010 998 5879 PMC8618701__F5 Proteomic Characterization of Plasma Rich in Growth Factors and Undiluted Autologous Serum 6010 5585 2670 23191 7045 85502 8505 998 2002 PMC8619339__F3 Nanostring-Based Identification of the Gene Expression Profile in Trigger Finger Samples 5447 50964 7454 6259 27130 10923 324 6500 29984 9475 25776 4088 PMC8621451__F5a Positive Salt Tolerance Modulation via Vermicompost Regulation of SOS1 Gene Expression and Antioxidant Homeostasis in Vicia faba Plant 759 6655 847 6654 PMC8621500__F7 Global Analysis of Transcriptome and Translatome Revealed That Coordinated WNT and FGF Regulate the Carapacial Ridge Development of Chinese Soft-Shell Turtle 9350 50964 27130 23002 324 6477 6500 387 8454 4088 51701 PMC8622657__F3 Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration 867 2885 2549 PMC8622975__F3 Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—From Molecular Mechanisms to Studies in Humans 7189 7099 100187907 3661 8717 729230 PMC8624829__F5 Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway 1103 858 859 613 1537 5266 3270 43 5350 717 4397 4151 3717 2548 90550 5447 5624 PMC8625415__F8 Prognostic Biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) Family Members in Breast Cancer 324 6402 3619 1059 79980 25936 79003 10403 55055 991 PMC8630009__F6 Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology 7124 8717 8772 4703 759 3976 2353 4149 6401 PMC8630042__F1 RAS/MAPK pathway downstream signaling and therapeutic targets 6009 4763 6237 2475 PMC8633417__F2 Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis 4609 999 7099 4615 5921 7124 1499 6608 PMC8634471__F2 Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer 1956 7099 4513 2932 3480 5728 PMC8634653__F1 Integrins in Gastrointestinal Cancer Metastasis 648 3091 2932 6657 6010 5879 998 PMC8637616__F1 Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagon-like peptide-1 analogs via the modulation of AKT-signaling pathway in Alzheimer’s disease 2475 5728 1499 PMC8639975__F4 Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training 952 43 3717 3371 816 818 4205 PMC8640807__F2 Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer 142 1869 23411 4363 5223 PMC8645759__F8 Notch‐1 signaling promotes reattachment of suspended cancer cells by cdc42‐dependent microtentacles formation 4851 998 10013 PMC8651359__F7 Exploring the Therapeutic Mechanisms of Huzhang–Shanzha Herb Pair against Coronary Heart Disease by Network Pharmacology and Molecular Docking 1674 4118 26136 54738 8139 6717 7216 6955 339855 619410 PMC8654299__F1 CoQ biosynthetic pathway of plant and the coexpression network 51805 51004 84274 27235 51117 3652 57017 PMC8655846__F2 TypiCal but DeliCate Ca++re: Dissecting the Essence of Calcium Signaling Network as a Robust Response Coordinator of Versatile Abiotic and Biotic Stimuli in Plants 867 2077 4602 22931 PMC8656569__F1 miRNAs in the Regulation of Cancer Immune Response: Effect of miRNAs on Cancer Immunotherapy 114609 4615 3654 7189 51135 23118 8717 8772 7186 1540 PMC8657105__F5 Histopathological and Molecular Profiling of Clear Cell Sarcoma and Correlation with Response to Crizotinib: An Exploratory Study Related to EORTC 90101 “CREATE” Trial 2064 6418 7157 4436 2956 PMC8657738__F4 Skin Aging, Cellular Senescence and Natural Polyphenols 4199 4018 47 1431 2744 4953 PMC8657824__F1 The Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens 7442 6418 59341 130497 PMC8660617__F9 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 324 545 472 675 5728 11186 699 983 9184 991 5347 6502 25859 1017 993 990 PMC8660617__F10 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 324 2099 545 472 3619 1059 79980 25936 1058 79003 64946 10403 5327 991 PMC8660617__F11 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 324 545 472 1956 991 983 1104 5901 22974 PMC8660617__F13 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 7494 2695 545 472 90865 613 5091 3920 847 6886 6010 7054 920 PMC8660617__F14 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 324 6476 545 472 7808 2177 80198 6608 PMC8660617__F15 Prognostic and immune infiltration signatures of proteasome 26S subunit, non-ATPase (PSMD) family genes in breast cancer patients 324 545 472 5901 260431 4282 1432 6300 5594 5073 79866 11065 PMC8663872__F7 To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology 4049 27040 4609 114609 100187907 1616 6770 4117 4149 23269 1636 930 27159 998 572 637 5894 7975 51083 8772 83737 7054 PMC8664605__F6 Integrative Analysis of DNA Methylation and Gene Expression Profiling Data Reveals Candidate Methylation-Regulated Genes in Hepatoblastoma 4609 472 545 4193 4089 1869 10487 1017 355 581 923 7249 5728 5111 1537 8318 8317 10926 64065 84883 993 637 4232 699 836 2475 PMC8664701__F2 Nutritional therapy can reduce the burden of depression management in low income countries: A review 1392 1312 7124 PMC8669959__F7 Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review 5728 5163 7422 847 54106 581 PMC8671096__F2 Construction of synthetic microbial consortia for 2-keto-L-gulonic acid biosynthesis 5211 3651 383 2806 4191 PMC8674449__F2 Ecogenomics Reveals Microbial Metabolic Networks in a Psychrophilic Methanogenic Bioreactor Treating Soy Sauce Production Wastewater 4118 7216 4810 6955 2271 PMC8674491__F3 Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment 3939 2475 7124 355 7038 196 3932 1445 PMC8678483__F8 Different Molecular Weight Polysaccharides From Dendrobium officinale Kimura & Migo on Human Colorectal Cancer and Transcriptome Analysis of Differentially Expressed Genes 581 27429 331 8772 PMC8685280__F5 Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment 7054 920 3952 50943 100187761 6418 PMC8687399__F10 Petri Net modelling approach for analysing the behaviour of Wnt/ ‐catenin and Wnt/ Ca2+ signalling pathways in arrhythmogenic right ventricular cardiomyopathy 100506742 836 581 22926 7186 9118 759 PMC8690896__F1 E-cadherin on epithelial–mesenchymal transition in thyroid cancer 1956 673 5728 2475 1803 999 406937 7124 6387 7852 PMC8692454__F4 Reconstruction of the Rhodotorula frigidialcoholis major carbohydrate metabolic pathways mapped with transcriptomic data 25796 5226 22934 9942 6652 5091 47 1431 4967 1738 6390 6391 4191 130589 2821 PMC8692906__F2 Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization 6502 4171 4999 23595 23594 3978 1763 4087 4088 4089 914 1869 1017 5111 923 4193 1537 1022 8318 8317 10926 993 699 4118 9184 5347 9126 10274 10735 991 PMC8698340__F2 Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature 2885 5058 7097 7189 114609 4615 7099 PMC8699889__F5 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 5901 324 545 472 2744 1356 1019 997 993 6502 847 1017 4088 6500 7465 PMC8699889__F6 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 7494 5906 8802 8801 3155 31 39 34 PMC8699889__F7 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 3458 324 1080 545 472 1636 9520 3416 5690 64167 1611 5699 23193 5045 10134 5721 55080 PMC8699889__F8 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 324 260431 3458 920 3455 8743 4860 PMC8699889__F9 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 324 260431 920 3619 1059 79980 1060 25936 79003 10403 8567 991 PMC8699889__F10 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 545 472 7852 4117 647979 572 55486 PMC8699889__F12 Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer 7054 759 613 27040 6697 847 6010 PMC8704013__F1 Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression 6347 435 3565 4942 PMC8704804__F1 Association of Genes of the NO Pathway with Altitude Disease and Hypoxic Pulmonary Hypertension 383 384 23576 23564 64902 PMC8710681__F3 Mitotic and DNA Damage Response Proteins: Maintaining the Genome Stability and Working for the Common Good 472 7507 699 4193 PMC8710987__F1 Metabolic dysregulation in bronchopulmonary dysplasia: Implications for identification of biomarkers and therapeutic approaches 2147 2597 2539 7086 6120 22934 95 435 PMC8712703__F6 Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis 2534 126669 6010 7408 3611 5163 572 PMC8714844__F3 Recent Progress in Lymphangioma 5163 1977 7249 PMC8725311__F2 Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier 4609 3725 572 PMC8740161__F3 Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells 23595 4999 8317 81620 5985 5984 5982 5111 990 4998 5426 847 5425 759 23041 PMC8740228__F4 Comparative Proteomic Profiling Identifies Reciprocal Expression of Mitochondrial Proteins Between White and Gray Matter Lesions From Multiple Sclerosis Brains 5213 1191 324 2098 6010 10750 1398 5898 6418 4099 5660 6767 8205 3371 1173 160 161 6844 5879 8775 5500 998 391 4905 396 63908 287 PMC8740576__F5 HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR 1977 2475 55421 96764 PMC8743870__F8 Triaging Down the 2021 Chest Pain Guidelines 790 100187761 367 PMC8745479__F1 Relevance of a Novel Circuit-Level Model of Episodic Memories to Alzheimer’s Disease 2932 998 7436 1600 PMC8746635__F7 Anti-Inflammatory Activities of the Ethanol Extract of Prasiola japonica, an Edible Freshwater Green Algae, and Its Various Solvent Fractions in LPS-Induced Macrophages and Carrageenan-Induced Paw Edema via the AP-1 Pathway 4615 3553 7099 4318 4313 PMC8748746__F2 DFT calculation of biosynthetic pathway of vaticahainol A and B 53366 1362 367 4397 PMC8758994__F3 Physiological regulation of DNL 23152 47 355 64326 PMC8761471__F14 Long non‐coding RNA MIR31HG as a prognostic predictor for malignant cancers: A meta‐ and bioinformatics analysis 27040 613 6850 930 4149 1610 51074 5728 1611 55824 572 6256 367 51083 790 5934 4602 1537 PMC8762348__F5 NMNAT3 regulating NAD+ in BMSCs to improve mitochondrial function and inhibit cell stress-induced apoptosis 23410 3418 847 PMC8763135__F3 Immune-targeted therapeutics and mechanisms of action investigated in major depressive disorder 3570 8564 4512 4513 114548 3606 PMC8766672__F2 Adaptive Mechanisms Make Lupin a Choice Crop for Acidic Soils Affected by Aluminum Toxicity 4397 1431 5183 417 PMC8772830__F1 Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways 23118 9817 7124 3654 51135 4615 7189 11315 PMC8779519__F3 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis 920 8178 8717 7187 27343 11201 7010 8772 4703 4137 4117 3934 3458 3034 PMC8779696__F1 Host Non-Coding RNA Regulates Influenza A Virus Replication 57506 3661 29110 3665 723778 407028 10379 3716 3717 6773 103 5371 PMC8780245__F7 Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCB1 signaling pathway in diabetic atherosclerosis 114609 4615 54472 3654 7189 5970 PMC8781679__F2 An Updated Review on the Modulation of Carbon Partitioning and Allocation in Arbuscular Mycorrhizal Plants 100187761 4397 355 PMC8781887__F1 Fission Yeast Cell Integrity Pathway: A Functional Hub for Cell Survival upon Stress and Beyond 5106 5105 466 10978 2203 PMC8782720__F8 Proposed model of the role of DAB2IP’s phosphorylation in SAC maintenance and cancer development suppression 983 153090 991 324 9184 PMC8784108__F4 Insight into the symbiotic lifestyle of DPANN archaea revealed by cultivation and genome analyses 3033 6908 2237 5424 5425 5423 PMC8785421__F1 Signaling pathway and polymorphisms of Mrgprs 7222 8989 3785 7442 84876 80228 8205 PMC8787213__F1 Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale 7368 3652 4598 PMC8799091__F5 Identification of significant genes in non-small cell lung cancer by bioinformatics analyses 613 930 6850 5728 572 6010 4703 2444 4170 4602 1537 PMC8804006__F1 Metabolic Transporters in the Peripheral Nerve—What, Where, and Why? 3939 24145 56666 PMC8806153__F3 Metabolism of memory CD8+ T cell differentiation 7248 7249 6009 355 4976 366 PMC8818156__F8 CENPF/CDK1 signaling pathway enhances the progression of adrenocortical carcinoma by regulating the G2/M-phase cell cycle 1063 1869 891 983 581 PMC8818883__F7 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis 8417 9341 203068 4353 811 7099 10333 948 8685 929 PMC8819670__F2 YAP/TAZ fusion partners and associated cancers 84441 256646 23261 PMC8820871__F4 Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure 22937 5728 11201 572 4118 2444 4602 1537 PMC8821549__F3 TR-binding and regulation of genes in the hedgehog signaling pathway in intestine based on ChIP-Seq and RNA-Seq data 6608 374654 8454 64399 596 55733 57467 57758 100379198 2121 8405 51684 8452 PMC8822596__F2 Ferroptosis in cancer and cancer immunotherapy 2937 2729 2879 2805 1723 55240 7163 7018 9474 7879 PMC8825370__F4 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer 2475 387 2885 4763 PMC8825490__F1 Macrophage Immunometabolism: A New Approach to Fight Infections 2597 5230 5315 3939 2271 4967 50 355 6520 PMC8832032__F4 Mitochondrial Quality Control: A Pathophysiological Mechanism and Therapeutic Target for Stroke 664 29110 9140 9474 10533 83734 65018 192111 PMC8834112__F4 Drosophila melanogaster: A Model System to Study Distinct Genetic Programs in Myoblast Fusion 375 5266 1398 5063 5058 PMC8834850__F2 Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma 581 6772 6774 1386 PMC8834850__F3 Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma 5080 2002 1386 2113 6772 4149 4609 466 5914 3150 PMC8835043__F1 Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin 1019 1017 983 PMC8835572__F2 Cancer as a Metabolic Disorder 4609 5728 3099 3939 PMC8835992__F7 Thyroid Hormone Receptor A Controls the Hind Limb Metamorphosis by Regulating Cell Proliferation and Wnt Signaling Pathways in Xenopus tropicalis 983 1021 6955 993 1019 995 1017 PMC8838402__F10 Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2 5340 302 2539 50507 PMC8839962__F1 Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases 2597 2821 5241 2475 3667 3630 6247 PMC8840921__F3 Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression 847 814 1385 PMC8841479__F1 Narrative review for the Hippo-YAP pathway in cancer survival and immunity: the Yin-Yang dynamics 4771 4485 60485 9113 374 3685 PMC8841529__F1 Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks 3980 7515 9156 672 4361 3981 7518 3978 5111 55183 6741 580 5893 8318 4172 4174 4173 4176 4175 4171 8317 641 2067 472 9656 83746 9025 165918 286257 2638 PMC8841724__F1 Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives 6999 196 3620 169355 PMC8842010__F6 Identifying individualized risk subpathways reveals pan-cancer molecular classification based on multi-omics data 10855 23002 8826 673 2002 7534 983 367 995 9088 324 7157 5591 1499 4117 1387 2033 2316 2122 4089 51701 2318 3727 4609 4661 595 57216 PMC8844014__F8 Alpha-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal 613 5266 3270 5350 90550 3371 PMC8863469__F16 29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses 5728 7157 4548 324 PMC8863963__F11 Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer 66037 613 6850 930 2534 5879 27159 126669 5728 2885 951 9760 7408 6010 3611 1398 572 6256 5934 150365 1537 PMC8864737__F2 WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization 619537 2203 268 5230 9049 417 5160 120114 2195 3417 5105 PMC8867093__F2 Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells 6510 2936 2876 PMC8870972__F3a Eutopic Endometrium Proteome in Endometriosis Reveals Candidate Markers and Molecular Mechanisms of Physiopathology 613 930 6850 5728 951 7249 6009 572 4193 5934 4170 PMC8872619__F4 miRNA and lncRNA Expression Networks Modulate Cell Cycle and DNA Repair Inhibition in Senescent Prostate Cells 387590 94009 5728 472 545 283120 4193 28996 6009 5478 618 PMC8873584__F1 SPINKs in Tumors: Potential Therapeutic Targets 10682 6774 6657 367 PMC8875753__F1 miR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensis 383 4843 384 4953 PMC8876688__F1 Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus 2729 2730 7295 140809 5315 5226 47 2194 5471 10797 3553 5684 55102 10533 84938 9474 PMC8877312__F3 Induced Expression of BPV E4 Gene in Equine Adult Dermal Fibroblast Cells as a Potential Model of Skin Sarcoid-like Neoplasia 1874 6502 1021 1019 4999 4171 23595 5000 4087 4088 4089 1017 990 4193 5111 1537 1022 8318 8317 10926 699 9184 4661 9126 10274 10735 991 PMC8882905__F4 Antiplatelet Therapy in Patients With MINOCA 4512 7450 3552 PMC8887676__F7 Therapeutic potential of the PI3K/AKT/mTOR axis for the management of AD and cancer 595 1017 1020 2475 PMC8890945__F6 Inhibitory effect on melanogenesis via PKA/CREB/MITF axis by DPN 100187761 4157 4286 PMC8894694__F4 Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection? 51284 59272 857 4615 3550 940 613 PMC8897867__F1 Activation of cryptic xylose metabolism by a transcriptional activator Znf1 boosts up xylitol production in the engineered Saccharomyces cerevisiae lacking xylose suppressor BUD21 gene 2023 2203 4118 7561 2656 PMC8899336__F1 Wnt signaling in biliary development, proliferation, and fibrosis 1499 324 51176 6010 PMC8900001__F2 Glycolysis in the progression of pancreatic cancer 3845 7157 2597 5230 5315 2669 PMC8904388__F1 Multifaceted Roles of cAMP Signaling in the Repair Process of Spinal Cord Injury and Related Combination Treatments 6010 10682 383 6590 PMC8905312__F1 Candida albicans stress response pathways in antifungal tolerance and resistance 27010 1255 907 PMC8905437__F1 Key Enzymes in Fatty Acid Synthesis Pathway for Bioactive Lipids Biosynthesis 9541 1896 2717 PMC8909913__F1 Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets 4092 10207 154796 4089 4485 1499 324 4086 174 6657 5054 PMC8910500__F1 Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling 1956 2247 5163 5165 2539 PMC8913874__F5 How water‐soluble saccharides drive the metabolism of lactic acid bacteria during fermentation of brewers' spent grain 2592 5066 2353 100187761 PMC8915814__F3 Versatile Functional Energy Metabolism Platform Working From Research to Patient: An Integrated View of Cell Bioenergetics 1431 2539 717 2936 718 2937 6647 6648 847 PMC8919014__F3 Inflammatory bowel disease-related colorectal cancer: Past, present and future perspectives 1499 6774 4609 8312 324 PMC8919593__F8 Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer’s disease 355 1386 3725 1506 PMC8920679__F3 Cellulosic Ethanol Production Using a Dual Functional Novel Yeast 5238 55276 2026 5132 50 131 127 3418 PMC8924487__F1 Extracellular Vesicles in Systemic Lupus Erythematosus 3732 3920 3383 9242 100423017 7189 1356 7124 6667 PMC8932107__F4 BDNF and TrKB expression levels in patients with endometriosis and their associations with dysmenorrhoea 627 126669 2885 PMC8941195__F2 RAS/MAPK pathway 2885 3726 1386 PMC8941195__F3 a. PLCG signaling pathway and b. PI3K pathway 847 5170 5163 PMC8941799__F1 Myocardial bioenergetics in the healthy and in the diabetic heart 1376 2821 3099 2597 8473 PMC8944541__F5 Venetoclax-Resistant MV4-11 Leukemic Cells Activate PI3K/AKT Pathway for Metabolic Reprogramming and Redox Adaptation for Survival 5163 2019 2020 PMC8945338__F2 Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway 4485 9113 26524 1499 6657 351 5308 6965 7514 10413 PMC8948438__F2 Exploring the Pharmacological Mechanisms of Xihuang Pills Against Prostate Cancer via Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo 6850 49 930 5879 5728 8213 951 7249 572 4193 6009 672 5183 5934 4602 1537 PMC8949121__F6 Integration of Transcriptomic and Proteomic Analyses Reveals New Insights into the Regulation of Immune Pathways in Midgut of Samia ricini upon SariNPV Infection 4040 4041 324 6477 6500 9978 PMC8949405__F2 MicroRNA-mRNA Regulatory Network Mediates Activation of mTOR and VEGF Signaling in African American Prostate Cancer 6714 998 5291 5595 5530 5829 3845 572 9261 842 PMC8952793__F8 Global MicroRNA Expression Profiling of Buffalo (Bubalus bubalis) Embryos at Different Developmental Stages Produced by Somatic Cell Nuclear Transfer and In-Vitro Fertilization Using RNA Sequencing 9350 50964 25805 6259 27130 6500 387 324 PMC8953452__F1 HOG pathway and the regulation of osmoadaptive responses in yeast 8466 717 10518 10519 117286 130106 7018 4360 729 PMC8957335__F2 Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma 6608 51684 2735 2736 2737 999 1499 PMC8958723__F3 In silico Prediction on the PI3K/AKT/mTOR Pathway of the Antiproliferative Effect of O. joconostle in Breast Cancer Models 7249 6009 2475 2885 253260 9846 5728 3667 867 331 581 572 PMC8964154__F7 Identifying Active Substances and the Pharmacological Mechanism of Houttuynia cordata Thunb. in Treating Radiation-Induced Lung Injury Based on Network Pharmacology and Molecular Docking Verification 2593 613 7939 930 27159 5728 83737 351 2056 1537 7012 PMC8966199__F8 Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780) 2147 468 22926 4508 11316 7186 4397 581 100506742 100187907 9156 258010 6402 6500 PMC8968663__F1 Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol 3652 3258 100682260 5091 3422 PMC8969394__F1 Biosynthetic pathways of triterpenoids and strategies to improve their Biosynthetic Efficiency 4598 9961 4597 3652 8213 PMC8970045__F3 Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn 7248 7249 6009 991 2475 10956 100187907 6400 258010 7353 9978 8454 6500 PMC8970045__F4 Full Functional Sex Reversal Achieved Through Silencing of MroDmrt11E Gene in Macrobrachium rosenbergii: Production of All-Male Monosex Freshwater Prawn 6955 54361 1017 5111 1105 PMC8976061__F4 Biosynthesis of the phosphonate antibiotic argolaphos A (3) 249 248 251 PMC8980325__F1 Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity 759 387 4512 4513 355 47 6319 3156 PMC8983706__F1 High-throughput translational profiling with riboPLATE-seq 2475 7249 7248 1977 6194 PMC8983858__F2 Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis 2475 59341 759 7450 10365 6010 5163 1003 5175 PMC8987581__F8 Anti-Inflammatory Effects of Ginsenoside Rb3 in LPS-Induced Macrophages Through Direct Inhibition of TLR4 Signaling Pathway 7099 4513 3553 PMC8990939__F6 Prolonged exposure to simulated microgravity promotes stemness impairing morphological, metabolic and migratory profile of pancreatic cancer cells: a comprehensive proteomic, lipidomic and transcriptomic analysis 998 387 2597 5315 3939 2194 2744 6510 PMC8992550__F1 Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment 7515 6741 7518 5888 672 5893 PMC8997602__F4 Impact of Lipid Metabolism on Antitumor Immune Response 3902 4513 8205 PMC9004589__F6 Astrocytes: The Housekeepers and Guardians of the CNS 7220 7224 7223 8989 59341 PMC9006795__F1 Aneurysmal subarachnoid haemorrhage—cerebral vasospasm and prophylactic ibuprofen: a randomised controlled pilot trial protocol 3383 339855 6010 4513 4512 717 PMC9010946__F9 Comprehensive Analysis on Prognosis and Immune Infiltration of Lysyl Oxidase Family Members in Pancreatic Adenocarcinoma With Experimental Verification 1674 6955 7054 3815 27040 PMC9013942__F2 Celastrol: An Update on Its Hepatoprotective Properties and the Linked Molecular Mechanisms 7186 3297 10487 23411 PMC9017276__F8 mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NFKB Signaling After Ischemic Stroke 115004 3661 383 PMC9019785__F9 Proprietary Medicines Containing Bupleurum chinense DC. (Chaihu) for Depression: Network Meta-Analysis and Network Pharmacology Prediction 355 7124 8717 4763 7186 1616 23118 2316 51701 7216 2002 4149 PMC9020799__F11 RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway 7099 114609 4615 114548 7124 3553 PMC9022112__F1 Nitric Oxide in Plant Senescence 847 2597 48 PMC9025460__F1 Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways 5625 1723 58472 29958 1757 PMC9029324__F2 Colorectal Cancer Diagnosis: The Obstacles We Face in Determining a Non-Invasive Test and Current Advances in Biomarker Detection 9350 50964 25805 6259 27130 324 29984 9475 3952 4089 4088 51701 PMC9030606__F1 Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies 114548 57506 64127 3665 3661 59272 3066 142 7297 3716 7054 51660 PMC9030951__F1 The Homeostatic Unfolded Protein Response in Diabetic Nephropathy 324 7494 581 83939 468 637 10628 22926 PMC9031373__F3 Evolving View of Uremic Toxicity 196 405 1956 PMC9034918__F6 Screening Potential Drugs for the Development of NAFLD Based on Drug Perturbation Gene Set 100188776 6955 351 PMC9038741__F5 Metabolic reconstruction of Angelarchaeales-1 genome 4118 11113 3240 PMC9043410__F4 Structure-based identification and pathway elucidation of flavonoids in Camptotheca acuminate 7054 7523 831 PMC9045977__F3 Mitochondrial Dysfunction Pathway Alterations Offer Potential Biomarkers and Therapeutic Targets for Ovarian Cancer 2242 6648 1537 27040 PMC9046588__F2 Protein Arginine Methylation: An Emerging Modification in Cancer Immunity and Immunotherapy 4609 383 948 604 3659 53630 2638 PMC9054177__F1 Molecular Basis of the Effect of Atorvastatin Pre-treatment on Stem Cell Therapy in Chronic Ischemic Diseases – Critical Limb Ischemia 3479 3481 6010 5163 572 581 2475 3091 7428 PMC9058032__F5 Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking 7124 183 7186 7187 1610 5624 4703 8213 80324 6401 759 5447 2242 3976 4323 274 64127 9021 7054 1279 PMC9062079__F2 Lens Aquaporins in Health and Disease: Location is Everything! 7442 59341 130497 PMC9062983__F1 Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism 6389 114548 596 581 790 PMC9093043__F1 Metabolic and epigenetic landscape of HSCs and downstream progenitors 56603 10763 100188795 100188837 3420 3417 5091 PMC9095844__F1 Thioredoxin-1: A Promising Target for the Treatment of Allergic Diseases 4282 1232 4067 695 6850 PMC9099743__F1 Advances in Understanding the Genetic Basis of Fatty Acids Biosynthesis in Perilla: An Update 5091 8694 84649 PMC9105460__F1 Immunotherapy for HER2-Positive Breast Cancer: Clinical Evidence and Future Perspectives 324 1493 940 3133 5979 PMC9113095__F8 Genetic evidence for the requirements of antroquinonol biosynthesis by Antrodia camphorata during liquid-state fermentation 27235 51805 84274 PMC9113527__F1 Enhancing HR Frequency for Precise Genome Editing in Plants 3981 5888 5893 PMC9113874__F7 Transactivation at C-TAD Domain of HIF-1A by Factor-Inhibiting HIF-1A (FIH-1): A Potential Target for Therapeutic Intervention in Cancer 85451 3091 7054 PMC9116906__F2 Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets 3550 7186 6774 11140 PMC9118284__F2 An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways 8717 7097 114609 114548 3553 4513 4318 4313 PMC9120357__F3 Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases 1509 23317 65018 9927 55737 PMC9122509__F6 Prostate cancer pathway 5163 7113 367 1027 5728 572 1537 1017 2078 7018 5327 5328 596 PMC9125579__F5 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues 3418 4118 2271 23530 5091 1431 10873 11113 50507 4199 2194 3417 PMC9130481__F2 Multiple roles of endocytosis and autophagy in intracellular remodeling during oocyte-to-embryo transition 857 11021 324 PMC9133699__F9 Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems 324 4118 3240 PMC9134593__F3 Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases 3665 29110 7187 3661 57506 8717 7186 7189 3553 PMC9136582__F1 Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy 8788 57551 9344 1386 6010 2002 2885 4208 PMC9137834__F4 Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications 2260 9817 6774 5728 2475 PMC9142082__F1 Double-Stranded Break Repair in Mammalian Cells and Precise Genome Editing 108570035 7486 11284 7518 3981 200558 286257 PMC9149409__F7 Long Noncoding RNA MEG3-205/Let-7a/MyD88 Axis Promotes Renal Inflammation and Fibrosis in Diabetic Nephropathy 27161 4615 3596 PMC9158463__F1 Understanding How Physical Exercise Improves Alzheimer’s Disease: Cholinergic and Monoaminergic Systems 23411 351 2932 387 PMC9172986__F5 An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis 6667 325 8775 51021 5447 221833 6671 4342 51199 PMC9172986__F6 An approach to cellular tropism of SARS-CoV-2 through protein–protein interaction and enrichment analysis 84135 84916 55272 92856 5822 10528 4809 28987 27343 11201 51068 55651 2147 2158 7450 5328 PMC9181642__F8 Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells 3630 5163 5164 PMC9184479__F6 Central metabolism of C. albicans is altered by L. rhamnosus colonization 2821 2597 4118 4397 249 1431 11113 PMC9189138__F2 Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT 7040 6010 1000 4921 1956 7852 6722 4067 1969 6659 PMC9192746__F5 Quercetin against atrial fibrillation explored by network pharmacology combined with molecular docking and experimental validation 929 3240 1616 1610 5624 92797 4149 PMC9197809__F1 Research progress on drugs targeting the TGFB signaling pathway in fibrotic diseases 9618 2885 2618 998 5062 6010 7046 PMC9200662__F7 Model for the role of the sequential modification of ERA by UFM1 and ubiquitin in the transactivation pathway 51569 55325 595 PMC9200993__F2 Treg Cell Metabolism and Function in Non-Lymphoid Tissues 3156 948 23411 50943 2475 7019 2729 2879 3441 PMC9204890__F5 Genome-wide alternative splicing profile in the posterior kidney of brown trout (Salmo trutta) during proliferative kidney disease 84726 10768 5794 7750 7168 56961 254048 27131 8508 87 4615 4976 23498 4151 57821 23207 5257 117584 55218 PMC9208181__F1 Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases 2475 6010 998 PMC9210989__F3 Significance of PAK4 in signaling and clinicopathology: A review 3082 1950 1956 7054 10298 5971 8717 2695 998 572 2669 PMC9214231__F3 Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe 1632 101928601 466 PMC9219682__F1 Enhanced 3T3-L1 Differentiation into Adipocytes by Pioglitazone Pharmacological Activation of Peroxisome Proliferator Activated Receptor-Gamma (PPARG) 4513 4023 10682 PMC9223523__F3 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa 4615 7275 7189 10522 PMC9223523__F4 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa 23429 8772 7189 790 23118 5966 619537 1805 1540 PMC9223523__F5 Mutations of GCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa 4615 7275 1386 5966 1540 23118 8772 PMC9224386__F4 Beneficial Effects of O-GlcNAc Stimulation in a Young Rat Model of Sepsis: Beyond Modulation of Gene Expression 2022 5970 10699 3552 1506 4099 10913 638 2122 4133 1147 6955 790 9063 100187761 8027 91653 7851 3416 207 6655 PMC9224557__F5a Key Immune-Related Genes in the Heart Following Burn Injury 3929 929 54472 100187907 23118 7454 11201 4311 8258 4284 6769 PMC9225081__F2 Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice 5888 5111 56852 118027463 PMC9228236__F4 Assessing Gene Expression Related to Cisplatin Resistance in Human Oral Squamous Cell Carcinoma Cell Lines 260431 6900 4359 1000 920 960 8205 79923 29984 7975 29102 PMC9231311__F4 Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants 79792 920 3458 4512 PMC9245023__F3 Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder 3479 3553 6010 2475 114548 PMC9250486__F4 Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited 1499 2475 5163 PMC9250793__F4 Signaling pathways in hair follicle stem cells 51684 2736 2737 6608 PMC9258689__F5 Interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data 5832 29920 5831 7939 6723 10454 PMC9265711__F1 LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo 998 3984 3985 6010 PMC9266554__F0 3-keto-DON, but Not 3-epi-DON, Retains the in Planta Toxicological Potential after the Enzymatic Biotransformation of Deoxynivalenol 6741 107966124 5978 759 790 831 5889 5890 641 6651 5697 8213 7851 100653365 572 5893 472 79728 675 PMC9266842__F2 Immunomodulatory Properties of PI3K/AKT/mTOR and MAPK/MEK/ERK Inhibition Augment Response to Immune Checkpoint Blockade in Melanoma and Triple-Negative Breast Cancer 2475 5163 5728 6502 3480 1956 PMC9267050__F2 Therapeutic Potential of the Restoration of the p53 Protein Family Members in the EGFR-Mutated Lung Cancer 4193 1956 5163 581 PMC9269291__F5 Potentilla paradoxa Nutt. Ethanol Extract Exhibits Anti-Inflammatory Effects by Suppression of the Src/NFKB Signaling Pathway 4615 6714 7099 PMC9270311__F3 Effects of Ginsenosides on PI3K/AKT signaling pathway 10533 5111 2475 2932 847 581 596 PMC9270353__F2 Liquid–liquid phase separation in tumor biology 472 10111 4361 2521 PMC9272703__F4 N-Glycosylation and Inflammation; the Not-So-Sweet Relation 7054 4247 50616 2821 6480 4249 PMC9273993__F3 Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer 2475 3579 3577 PMC9277014__F1 Roles of TNF Signaling Pathways in Metabolism of Bone Tumors 8772 8717 7186 PMC9278165__F6 Comparative Transcriptome and Metabolome Analysis of Resistant and Susceptible Piper Species Upon Infection by the Oomycete Phytophthora Capsici 64781 1879 4881 790 PMC9279440__F5 Investigation on the cellular mechanism of Prunetin evidenced through next generation sequencing and bioinformatic approaches against gastric cancer 3466 3014 7098 1540 637 8772 2752 834 4015 PMC9279477__F2 Calculated excited states of Pd-DPAphos complexes and synthesis of DPAsphox (1) 6654 4827 6418 6655 PMC9283756__F2 Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis 28999 8213 1401 1581 170302 PMC9283766__F2 Insights Into the Role of Platelet-Derived Growth Factors: Implications for Parkinson’s Disease Pathogenesis and Treatment 1499 3725 7054 PMC9284893__F8 RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface 7124 1950 2885 998 4615 355 929 7189 10454 23118 51295 7186 1616 4485 5894 2316 4351 51701 994 2002 3727 4149 4208 PMC9284958__F1 Comprehensive network map of IL-17A signaling pathway 4280 7010 140805 5970 6772 3976 PMC9290759__F2 Association of Gut Microbiota and Treg Dysfunction in Autoimmune Diseases 4513 196 7097 PMC9297740__F1 PARP Inhibitors in Glioblastoma and Perceiving Challenges as Well as Strategies for Successful Clinical Development 4255 4436 2956 PMC9298548__F3 Comparative Transcriptome Analysis Reveals the Mechanism Associated With Dynamic Changes in Meat Quality of the Longissimus Thoracis Muscle in Tibetan Sheep at Different Growth Stages 3630 1080 948 3643 5163 5164 2147 7249 23411 6009 2475 355 PMC9304652__F2 Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin 2475 581 6774 PMC9305269__F4 Effect of a Functional Phospholipid Metabolome-Protein Association Pathway on the Mechanism of COVID-19 Disease Progression 5091 3931 9350 64781 PMC9309761__F4 Analysis of Competitive Endogenous RNA Regulatory Network of Exosomal Breast Cancer Based on exoRBase 1869 4609 472 545 1537 3732 64065 572 637 PMC9312280__F4 Evaluation of Proanthocyanidins from Kiwi Leaves (Actinidia chinensis) against Caco-2 Cells Oxidative Stress through Nrf2-ARE Signaling Pathway 9817 581 4094 PMC9312335__F4 High-Temperature Stress Effect on the Red Cusk-Eel (Geypterus chilensis) Liver: Transcriptional Modulation and Oxidative Stress Damage 1998 468 22926 4397 596 100506742 6396 9156 100187907 258010 PMC9312508__F10 Host-Genome Similarity Characterizes the Adaption of SARS-CoV-2 to Humans 4615 51284 7098 57506 7187 7189 10010 29110 3716 7297 6773 PMC9312970__F9 Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway 7099 2730 79792 PMC9314982__F3 Coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy 7018 4035 7436 PMC9319031__F2 Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health 5111 1019 2475 331 55553 595 3005 4255 PMC9321239__F7 Altered RNome expression in Murine Gastrocnemius Muscle following Exposure to Jararhagin, a Metalloproteinase from Bothrops jararaca Venom 1950 355 929 7124 8717 2241 7186 1610 23118 51295 1616 3240 351 57136 2316 4351 51701 4703 4149 6722 PMC9322645__F8 Molecular Processes of Dodder Haustorium Formation on Host Plant under Low Red/Far Red (R/FR) Irradiation 790 57716 1312 3005 PMC9322890__F5 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) 6714 2475 4088 581 317 842 836 PMC9322890__F7 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) 4087 4088 4092 2932 9817 842 836 PMC9322955__F1 Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts 9817 7808 7124 PMC9324263__F7 Disruption of O-GlcNAcylation Homeostasis Induced Ovarian Granulosa Cell Injury in Bovine 10628 10724 998 5111 581 PMC9324353__F2 Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 596 10576 8772 1956 2475 581 355 1616 1019 PMC9329830__F1 Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation 6678 7374 1803 2167 685 3934 9518 5950 8404 7873 PMC9331286__F1 T Helper 22 Cells in Dermatological Disorders 6772 3716 3553 7297 196 6774 1233 1235 2826 2475 PMC9333902__F1 Immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review) 7098 7706 3661 PMC9338502__F3 Bioinformatics analysis and experimental verification of Notch signalling pathway-related miRNA–mRNA subnetwork in extracellular vesicles during Echinococcus granulosus encystation 8650 23385 3280 388585 100188776 PMC9348576__F2 Products of deregulated genes in Dp(16)1Yey/+ are enriched in proteins linked to glutamate receptor signaling pathway and in proteins involved in an ARC–PSD95 complex linked to ID and intelligence 3265 9615 85358 9743 PMC9352453__F1 Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19 100187907 1636 59272 PMC9353479__F6 Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co‐Culture Chip 5054 4609 2475 595 1956 PMC9353721__F4 Analysis of Protein–Protein Interactions Identifies NECTIN2 as a Target of N,N-Bis (5-Ethyl-2-hydroxybenzyl) Methylamine for Inhibition of Lung Cancer Metastasis 3643 4008 2241 2534 387 4089 23440 998 51701 PMC9353920__F6 Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study 324 7124 196 50615 7186 7187 149233 920 27040 3466 1610 8772 6778 843 3662 2625 50943 9118 6095 6651 4323 1906 7185 3976 9021 PMC9355550__F2 Combinatorial Strategies With PD-1/PD-L1 Immune Checkpoint Blockade for Breast Cancer Therapy: Mechanisms and Clinical Outcomes 367 324 940 920 PMC9356782__F6 Renshen Baidu Powder Attenuated Intestinal Inflammation and Apoptosis in Ulcerative Colitis Rats through the Inhibition of PI3K/AKT/NFKB Signaling Pathway 930 759 5728 951 7249 572 5934 PMC9357648__F8 lncRNA XLOC013218 promotes cell proliferation and TMZ resistance by targeting the PIK3R2‐mediated PI3K/AKT pathway in glioma 5296 2932 6667 5163 2475 581 PMC9358258__F14 Neuroprotective Drug Discovery From Phytochemicals and Metabolites for CNS Viral Infection: A Systems Biology Approach With Clinical and Imaging Validation 27040 5972 3586 7124 3661 6772 3725 PMC9360520__F1 Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: a narrative review 4087 4088 4089 PMC9365139__F4 The effects of ATRA treatment of hyperoxic A549 cells 7054 351 7216 8213 PMC9367165__F2 Twinkle twinkle brittle star: the draft genome of Ophioderma brevispinum (Echinodermata: Ophiuroidea) as a resource for regeneration research 5045 64746 8650 222484 23509 100188776 4734 3065 145873 PMC9368248__F6 Molecular Regulation of Yak Preadipocyte Differentiation and Proliferation by LncFAM200B and ceRNA Regulatory Network Analysis 23385 8650 5371 3280 388585 100188776 991 PMC9371493__F8 Active compounds and molecular mechanism of Xuefu Zhuyu decoction for atherosclerosis, based on network pharmacology and molecular docking 3717 6774 6401 4313 7124 7018 5300 PMC9371685__F4 Sulfur and methane oxidation by a single microorganism 4810 6010 717 1537 65057 PMC9379405__F5 Intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways 5045 4734 8650 3280 388585 23385 896 PMC9382818__F1 Improved energy efficiency in microbial fuel cells by bioethanol and electricity co-generation 4151 4190 4191 5132 3418 3417 PMC9387202__F10 The gut microbiota and lipidomic profiles by black chokeberry (Aronia melanocarpa L.) polyphenols via the glycerophospholipid metabolism signaling pathway 5337 5338 5091 54947 3931 PMC9396482__F1 Wnt/Beta-catenin signaling: a multifunctional target for neuroprotective and regenerative strategies in Parkinson’s disease 324 22943 847 7471 1267 PMC9402571__F6 Models for the negative regulation of NFKB signaling pathways by caspase-3-mediated cleavage of NFKBs 842 836 8772 PMC9409283__F2 Analysis of Amino Acids in the Roots of Tamarix ramosissima by Application of Exogenous Potassium (K+) under NaCl Stress 133 100188776 847 654231 7054 PMC9410115__F1 Pathophysiology of Coagulation and Emerging Roles for Extracellular Vesicles in Coagulation Cascades and Disorders 324 7450 5340 7018 9015 PMC9411814__F6 Investigation of the mechanism of the anti-cancer effects of Astragalus propinquus Schischkin and Pinellia pedatisecta Schott (A&P) on melanoma via network pharmacology and experimental verification 613 930 3667 5879 5728 572 4193 4703 5934 1537 PMC9415106__F4 Application of Mesoporous Silica Nanoparticles in Cancer Therapy and Delivery of Repurposed Anthelmintics for Cancer Therapy 2475 6774 1019 1499 100187761 1956 10413 PMC9420268__F1 Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response 1019 10818 8074 2251 894 2549 2885 2475 1021 PMC9420733__F3 Signaling pathways in obesity: mechanisms and therapeutic interventions 4054 9573 238 9518 5979 389400 7350 155 5443 181 4852 PMC9422807__F2 Comparing the Cytokine Storms of COVID-19 and Pandemic Influenza 4118 7124 4283 3627 50616 355 6348 100187761 PMC9423640__F2 Key genes pathway identification and potential drug design 3172 759 7808 4821 5078 PMC9428719__F7 Metabolic management of microenvironment acidity in glioblastoma 6098 5019 3939 2806 PMC9434279__F1 Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus 22926 3375 3553 PMC9436900__F4 PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities 572 581 5728 5163 7099 PMC9437628__F4 System level modeling and analysis of TNFA mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets 5163 637 836 8772 8717 835 7124 10486 7186 PMC9443660__F5a Targeting spike protein-induced TLR/NET axis by COVID-19 therapeutic NRICM102 ameliorates pulmonary embolism and fibrosis 1636 59272 2717 4099 6955 717 4117 1311 103 6886 PMC9452849__F13 Hope for bone regeneration: The versatility of iron oxide nanoparticles 860 4958 5156 2260 2885 22943 1499 PMC9453879__F7 Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARA pathway in diabetic rats 335 4023 5091 5360 7350 3611 7316 4312 5163 390928 PMC9453976__F3 Emerging ROS-Modulating Technologies for Augmentation of the Wound Healing Process 6420 4094 23411 3553 7189 PMC9456528__F2 DNA Holliday Junction: History, Regulation and Bioactivity 5888 146956 84464 PMC9463773__F1 Diversification of PAR signaling through receptor crosstalk 6010 324 5879 PMC9464914__F1 Pinocytotic engulfment of lipoproteins by macrophages 998 38 5879 7099 6363 57703 10000 961 PMC9465383__F1 Reprogramming lipid metabolism as potential strategy for hematological malignancy therapy 948 8237 2194 2475 10221 22937 3949 PMC9466593__F1 Effect of antifungal resistance development on the virulence of Candida species 1039 1038 213 PMC9467317__F4 TI2-induced subnetwork 7124 8717 5624 197259 581 1540 3550 331 8772 1356 1674 84733 351 836 842 PMC9467392__F7 High expression of CCNB1 driven by ncRNAs is associated with a poor prognosis and tumor immune infiltration in breast cancer 444 4239 4118 1537 5111 4199 PMC9475012__F1 Neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review 3667 627 23621 64422 10533 8195 1020 83939 1499 PMC9477627__F8 Identification of Molecular Targets and Underlying Mechanisms of Xiaoji Recipe against Pancreatic Cancer Based on Network Pharmacology 6497 355 7124 2885 5879 10486 7054 8205 4232 2316 828 4609 4149 100187761 4602 PMC9482139__F1 Energy metabolism pathways in breast cancer progression: The reprogramming, crosstalk, and potential therapeutic targets 3939 2539 26227 5723 2744 2194 2271 PMC9484955__F6 Protective Effect of Natural Medicinal Plants on Cardiomyocyte Injury in Heart Failure: Targeting the Dysregulation of Mitochondrial Homeostasis and Mitophagy 4976 4221 51024 139341 664 PMC9485629__F1 Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression 655 1956 1950 999 7045 920 PMC9485831__F4 Biochemical and physiological insights into TRH receptor-mediated signaling 673 6714 7200 2885 156 2932 1499 PMC9486394__F1 Regulation and coordination of the different DNA damage responses in Drosophila 545 983 472 PMC9486394__F2 Regulation and coordination of the different DNA damage responses in Drosophila 10724 545 983 472 PMC9489775__F5 Selected transcripts of developmental signaling pathway genes implicated in dorsoventral and/or anteroposterior patterning containing two or more RNA editing sites detected at their 3′-UTR region 3716 27 10152 10979 8558 3978 3092 4952 81790 1856 7855 81847 2137 1846 6383 3996 2133 54623 3611 5311 83892 93 PMC9496697__F1 GSK3 Is a Central Player in Retinal Degenerative Diseases but a Challenging Therapeutic Target 7249 7248 5728 5447 5966 108348016 1499 PMC9498798__F5 Gene Regulation during Carapacial Ridge Development of Mauremys reevesii: The Development of Carapacial Ridge, Ribs and Scutes 6608 50964 25805 27130 8454 2922 596 324 64399 100379198 6500 2121 156 51684 8452 8405 4088 PMC9500598__F2 Circular RNAs Involved in the Regulation of the Age-Related Pathways 3630 3643 7249 2475 5728 2932 4193 7248 6009 64798 9865 PMC9503257__F6 Intestinal microbiome-mediated resistance against vibriosis for Cynoglossus semilaevis 1593 7096 7097 5879 60481 51 7187 7098 10010 29110 3665 3661 PMC9503372__F9 Disruption of the Chitin Biosynthetic Pathway Results in Significant Changes in the Cell Growth Phenotypes and Biosynthesis of Secondary Metabolites of Monascus purpureus 2695 355 400 759 PMC9510994__F8 Integrated volatile metabolomic and transcriptomic analysis provides insights into the regulation of floral scents between two contrasting varieties of Lonicera japonica 26136 3652 3156 4598 PMC9513044__F1 Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment 383 4843 6774 PMC9513835__F7 Molecular Mechanisms of Spawning Habits for the Adaptive Radiation of Endemic East Asian Cyprinid Fishes 1431 5217 2 7783 PMC9519154__F1 Exploring autophagy-related prognostic genes of Alzheimer’s disease based on pathway crosstalk analysis 6401 3630 574 8772 8544 759 4342 836 90550 4508 717 351 572 7275 286205 PMC9523578__F3 Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity 578 8454 6500 64781 6104 PMC9524038__F2 Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption 4745 1499 860 324 85445 PMC9524953__F6 Identification of a functional circRNA-miRNA-mRNA regulatory network in infantile hemangioma by bioinformatics analysis 3466 3939 6774 1977 5163 8650 23385 7428 8453 2056 7018 51083 7012 2597 226 3280 388585 100188776 PMC9530810__F5 Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary 759 7975 355 929 80763 3939 1616 8453 2316 3242 100306940 2160 10 4149 126669 4342 5163 5211 7012 PMC9530868__F7 Ubiquitin‐specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma 1499 6934 324 55294 57646 595 PMC9531712__F1 Targeting ligand-dependent wnt pathway dysregulation in gastrointestinal cancers through porcupine inhibition 1499 4040 4041 2932 324 1386 3725 4920 4919 23002 998 387 PMC9532189__F1 Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition 2876 4256 100187907 PMC9539685__F2 Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development 6009 5728 5163 261726 PMC9550229__F2 Screening and validation of nickel ion cytotoxicity biomarkers based on transcriptomic and proteomic technology 1435 27040 1398 5900 7410 8205 790 PMC9551334__F9 Acute Manganese Exposure Modifies the Translation Machinery via PI3K/Akt Signaling in Glial Cells 6714 1938 7249 7248 6009 5728 5163 1977 PMC9553959__F3 Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways 613 930 3667 5879 5728 5163 951 7249 572 6009 51083 672 5934 PMC9554879__F5 Immunogenic cell death related risk model to delineate ferroptosis pathway and predict immunotherapy response of patients with GBM 920 8178 6418 100187761 114034 3630 PMC9561988__F1 Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer 1019 142 6741 4193 7515 1017 472 993 7518 7465 545 995 675 5888 PMC9565759__F4 Possible Synergies of Nanomaterial-Assisted Tissue Regeneration in Plasma Medicine: Mechanisms and Safety Concerns 6774 9055 9973 6647 6648 PMC9570193__F8 Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease 51083 2717 759 1191 4118 2695 10750 11113 7851 6120 4018 4342 4099 4597 100 100187761 3034 3630 PMC9570382__F1 Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer 2254 693122 728655 100302185 PMC9572368__F2 Ubiquitin–Proteasome System (UPS) and Viral Infection in Plants 6500 717 4077 9978 PMC9577257__F2 WNT signaling at the intersection between neurogenesis and brain tumorigenesis 324 1499 23002 23500 5879 6010 998 PMC9577795__F3 Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis 113189 5603 5606 6678 3630 3479 7471 1128 9508 5764 5376 6837 6752 58480 5008 47 3914 6772 7450 3725 650 1278 367 PMC9580888__F4 Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis 2475 124976 6653 PMC9585259__F2 Changes in the urinary proteome before and after quadrivalent influenza vaccine and COVID-19 vaccination 6651 226 1191 22944 1675 5005 1950 197 387 3700 7123 823 335 2817 2782 337 998 2934 348 81 718 7316 3684 1471 2619 7450 PMC9586542__F6 Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease 2581 1609 5091 7038 PMC9589424__F3 TSH−SPP1/TRB−TSH positive feedback loop mediates fat deposition of hepatocyte: Crosstalk between thyroid and liver 1610 572 4193 5208 9118 PMC9600294__F5 Adipokines as Regulators of Autophagy in Obesity-Linked Cancer 10533 3949 2475 5465 3479 581 8408 9140 9474 PMC9601210__F7 Therapeutic Targeting of NFKB in Acute Lung Injury: A Double-Edged Sword 6850 5970 3383 PMC9601721__F3 Whole-Exome Sequencing Reveals Pathogenic SIRT1 Variant in Brain Arteriovenous Malformation: A Case Report 3630 3643 5728 6774 51701 6502 4193 1017 7874 84188 664 10365 9140 472 PMC9609926__F4 Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease 7189 8772 57506 10010 3661 3665 7098 10379 6773 23118 7297 257397 PMC9611771__F3 Identification of differentially expressed genes in mouse paraspinal muscle in response to microgravity 7054 572 6651 27040 351 5339 51083 1674 PMC9613846__F3 Transcriptome and Metabolome Analyses Reveals the Pathway and Metabolites of Grain Quality Under Phytochrome B in Rice (Oryza sativa L.) 6389 4015 1879 64641 4190 578 51411 2000 130589 1738 197322 1997 10209 1998 4350 2597 4149 54205 PMC9614365__F1 Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases 50943 2744 3458 51176 PMC9617479__F1 Metabolic features of innate lymphoid cells 1431 47 2744 38 PMC99013__F3 Signal transduction cascades regulating pseudohyphal differentiation in S 998 8466 27010 PMC9963318__F3 MYC2: A Master Switch for Plant Physiological Processes and Specialized Metabolite Synthesis 81857 27343 11201 PMC10030580__F2 Macrophages in aseptic loosening: Characteristics, functions, and mechanisms 2475 4049 4615 7189 23118 257397 3553 114548 PMC10030840__F2 Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases 4913 9156 175 2073 2176 PMC10040598__F1 The inflammasome in insulin resistance and type 2 diabetes mellitus 2885 3667 2475 5163 PMC101920__F1 Late steps of AdoCbl biosynthesis in S 351 84890 4200 PMC1052008__F1 Activation of PI3K/Akt signaling in adaptive versus maladaptive hypertrophy 5728 5163 2475 PMC1088000__F4 In Silico Analysis of the L 95 2153 730 PMC1168814__F8 The regulation of replication-dependent histone H4 genes at the G1/S phase cell cycle transition via the cyclin E/CDK2/p220/HiNF-P pathway relative to the E2F/pRB pathway 1021 1019 1017 1719 PMC118037__F6 Model depicting direct and indirect regulation of clock output genes involved in conidiation 100418973 649024 9575 PMC1201250__F7 Mechanism of TgHSP70 tolerance in PMs from WT mice 7038 7097 7099 4615 3654 3661 7189 PMC1201514__F1 Regulation of the PIS1-encoded Phosphatidylinositol Synthase in Saccharomyces cerevisiae by Zinc 2821 1040 84249 PMC120784__F8 Outline of the cell integrity pathway 11043 6094 1255 PMC122866__F4 The pathway of PUFA synthesis in C 120114 2195 2196 79633 PMC1236698__F2 Molecular mechanisms of autophagy 9776 5266 22863 9140 83734 9474 10533 64422 PMC126023__F7 Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae 4968 5810 3622 80198 PMC136456__F7 The modulation of cellular signaling pathways by NS5A 2549 2885 572 PMC1375233__F5 Two signaling pathways of TLR in myeloid DCs 929 7098 7097 7099 4615 4118 3654 51135 7189 23118 10454 3661 PMC1383660__F5 Intracellular signalling pathways activated by leptin 2885 5266 1958 PMC138693__F2 Phosphoinositide 3-kinase (PI3K) signalling and cancer 5728 5163 672 472 PMC1434604__F1 Sites of action for reactive oxygen species in the regulation of the insulin signaling pathway 5266 5728 2885 2475 PMC1456930__F5 The molecular pathways controlling AB generation during aging 3479 3480 5728 8660 PMC151063__F9 p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop 581 780 4193 PMC151822__F2 Signaling UPR-mediated cell death 440514 7186 468 22926 PMC1525002__F4 Sequence logo [41] of putative regulatory motif 5230 2023 2026 127 128 PMC1525234__F6 Working model of regulatory mechanisms controlling cell death in response to mating pheromones 116844 2744 4281 PMC1526532__F1 Genomic Analysis of the Opi− Phenotype 4311 5091 84249 PMC1533821__F2 Recognition of pathogens by cytosolic PRRs 10392 8772 3661 PMC1564204__F6 Schematic pathway of lipid turnover induced by Pi stress 5091 6647 6648 PMC1579207__F3 Cadmium-induced regulation of SCFMet30 997 6500 914 PMC1609106__F8 Regulation of insulin pathway phenotypes by AKT-1 and PDK-1 activation 5163 207 208 PMC1636619__F8 Oncogene cooperation in malignant rasV12, scrib−/− tumors 23513 2353 4312 PMC1664664__F2 Neurotrophin signalling 10818 2885 3725 6010 PMC1773546__F3 The key proinflammatory pathway induced by enteric pathogens results in nuclear factor kappa B (NFKB) mediated transcription of interleukin 8 (IL-8) 7186 7189 382 4615 7100 PMC1774275__F5 Mitogenic signals are transduced by Ras which inhibits the retinoblastoma (Rb) protein allowing E2F and Myc to promote cell cycle progression 4609 5728 581 637 4193 355 572 PMC1774670__F2 Interaction of JC virus (JCV) T-antigen with key growth regulatory pathways 595 4193 1499 3667 PMC1774670__F6 P53 pathway 4193 581 5111 PMC1797585__F9 Working model for NS action 572 57762 1956 PMC1828071__F3 Diagrammatic representation of insulin on growth factor signaling through the Ras-Raf, MEK-ERK signaling pathway with downstream effects on gene transcription through ERK translocation 2885 1398 2887 PMC1828869__F2 Regulation of induction and vesicle nucleation 9776 22863 5163 5728 6009 7248 7249 PMC1832150__F1 CoQ10biosynthetic pathway with eight known biosynthetic enzymes denoted as COQ1-8 27235 51805 51004 84274 10229 PMC1852756__F2 The small nuclear ribonucleoprotein biogenesis pathway 2669 5901 51808 7514 10419 96764 PMC186370__F1 Spot 42 RNA mediates discoordinate expression of the E. coli galactose operon 1401 2592 130589 2582 51083 PMC1885790__F3 Diagram illustrating how the Rb and p53 pathways are linked to form a complex tumor suppressor network 4609 1019 4193 581 PMC1890373__F2 Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands 948 2597 95 7959 545 1158 PMC1895551__F1 Prosurvival signaling pathways and their downstream targets 2885 100303716 572 836 PMC1899380__F1 Late steps in corrin ring biosynthesis in serovar Typhimurium 351 100 84890 4693 367 4827 PMC196255__F1a Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway 8471 3667 8660 5163 5728 2475 PMC2013735__F4 GenMapp pathway showing the impact of 1 week of STZ-DM on transcription in pathways related to cytokines and the inflammatory response 2669 2780 55740 7454 PMC2043401__F1 Schematic outline of fatty acid synthesis in apicomplexans 1356 3989 3988 4118 355 PMC2063509__F1 AUTOPHAGY: HIGHLIGHTING A NOVEL PLAYER IN THE AUTOIMMUNITY SCENARIO 3479 7124 10533 64422 3565 2475 9776 PMC2097959__F2 INTEGRATING RADIOTHERAPY WITH EGFR ANTAGONISTS AND OTHER MOLECULAR THERAPEUTICS FOR THE TREATMENT OF HEAD AND NECK CANCER 1956 2885 2549 5163 2475 4513 PMC2100073__F6 Filamentation signaling pathway recovered completely 999 8317 998 84188 PMC2168724__F1 Coenzyme B12 biosynthesis in serovar Typhimurium 84890 351 4693 4827 PMC2169053__F6 Model for SCF-mediated regulation of hFBH1 and Srs2 turnover in response to DNA damage 84893 118027463 5111 6500 56852 PMC2223843__F2 TLR3 signaling pathways 7098 23118 3661 PMC2224586__F3 HCMV regulates the expression of multiple components of the NFKB signaling pathway (see Table and Table S1 in the supplemental material for abbreviations) 650 652 1950 4803 7124 4049 958 114609 3932 5970 5971 PMC2242778__F5 Canonical pathway analysis 387 1398 5829 PMC2254474__F1 P2Y receptor-mediated signalling cascades in C6 cells 84890 2885 387 2670 3725 PMC22667__F1 Pheromone response pathway in yeast and summary of epistatic interactions with STE4 and STE11 998 84188 1201 PMC2268699__F2 FGF canonical signalling pathway 1398 3708 6774 9261 PMC2276852__F7 Schematic representation of the proposed events triggered by exposure to replication inhibitors such as APH 545 80198 641 7518 PMC2278039__F2 FIP200, a key signaling node to coordinately regulate various cellular processes 7186 5925 7249 7248 595 2475 PMC2288663__F6 Nucleotide excision repair pathway 1362 7508 7507 7018 2067 5111 PMC2349095__F2 Triggering and amplification of the Wnt/Beta-catenin pathway in osteocytes in response to load 4041 3611 50964 7018 PMC2360352__F1 Schematic depicting the central role of HER3 in mediating PI3K/Akt signalling downstream of the HER family 1956 5728 2475 572 PMC2374962__F2 Regulation of glycolysis and fatty acid synthesis 2194 1374 57103 9997 PMC2387053__F2 Aging of the brain, neurotrophin signaling, and Alzheimer’s disease: is IGF1-R the common culprit? 3479 3480 5728 PMC2390552__F11 ERK1 and ERK2 knockdown differently affect signals involved in patterning of the early embryo 57154 11059 9241 10468 145258 6911 140628 4838 10253 81848 PMC2390552__F9 Analysis of BMP signaling processes in ERK1MO and ERK2MO gene expression profiles 168667 6591 2782 10399 3399 5095 659 93 25805 9241 10468 PMC2398704__F3 High and low pollen-hoarding strain bees 5303 3479 5300 PMC2409816__F1 Schematic representation of the major pathways of ganglioside biosynthesis 51083 6489 112483 8705 PMC2424235__F1 Auxin signaling 55832 8454 9978 PMC2442829__F2 Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations 1956 4193 2475 PMC2446520__F1 The GNB/LNB pathway and related enzymes 2022 51083 2592 2733 2582 PMC2474943__F5 Points of action of flavonoids within p38 pathway 10454 1386 2002 4149 PMC2483757__F1 Kinetic model of the EpoR/GATA-1 network implicated in erythrocyte progenitor commitment 2056 2057 3717 PMC2484121__F2 Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs): Multifunctional proteins in cancer 1758 960 5266 5728 PMC2490739__F8 Scheme summarizing the differential effect of PARP-1 inhibition versus silencing on SSB repair via the BER pathway 6741 6697 5111 PMC2504032__F8 Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine 83939 468 890 1017 PMC2504760__F1 Mechanisms by which diabetes increases cardiovascular disease 367 3383 7412 7124 948 PMC2517145__F1 PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells 3667 5728 6010 1977 595 PMC2519122__F1 Role of mTOR in anticancer drug resistance 2885 3667 4763 5728 5163 7248 6009 1977 PMC2519541__F2 Integration of the AinS-AinR and LuxI-LuxR quorum sensory pathways 1636 112950 729 PMC2528845__F2 Intracellular signaling activated through FGFRs 10818 2885 2549 126669 PMC2528847__F2 Integration of genomic and nongenomic/rapid ER signaling and its crosstalk with growth factor receptor and cell kinase pathways in endocrine resistance: a working model 8205 1839 1956 7018 PMC2533786__F9 PI 3-kinase/AKT-dependent pathways involved in IL-1 induction of IL-6 5266 54472 4615 51135 7189 23118 PMC2553363__F2 ER stress pathway 22926 7186 83939 7494 468 PMC2556866__F1 Telomere structure and DSB processing 545 5888 5893 PMC2562939__F1 The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin 1801 51611 1802 285381 PMC2566006__F2a A Defect in Menadione Biosynthesis Induces Global Changes in Gene Expression in Staphylococcus aureus 5066 130589 202309 978 6390 6391 6389 7086 51430 5132 100 2717 100188011 PMC2566927__F2 Essence of retrograde signaling in model organisms 1017 54903 14 PMC2567511__F1 The tetrapyrrole pathway in plants showing intermediates and genes analyzed in this study 2973 210 7390 7389 130749 5447 PMC2570299__F3 Role of GalGlyNAcPVv in V 28 51083 55577 2592 2582 101448070 PMC2577715__F4 NFKB signaling and MDR gene expression 958 4615 5971 PMC2583931__F1 Migrating D-loop model of recombination 23626 4361 9156 10111 5888 5893 4439 4438 4292 80198 84893 118027463 PMC2584809__F6 Schematic model illustrating constitutive vs 4852 6616 7054 5409 8618 1621 PMC2593676__F6 Gene expression and metabolite levels in the distal network pathways related to Met- and Trp-derived GS biosynthesis 2937 867 4397 PMC2601639__F1 Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain 717 5163 5728 PMC2601664__F1 Membrane-initiated Estrogen Signaling in Hypothalamic Neurons 1950 1839 6714 1956 PMC2612755__F5 A theoretical pancreatic endocrine tumor cell, smooth muscle cell (pericyte) or endothelial cell demonstrating the sites and mechanism of action of novel agents for the management of metastatic PETs 1956 2322 2475 5728 PMC2623309__F1 Multiple feedback loops of p53 pathway 4193 1017 5728 6477 1499 900 1432 PMC2633299__F11 UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes 23236 4512 5228 7011 PMC2635127__F1 Erk non-Smad pathway 2885 4089 4088 PMC2636986__F1 Adaptor protein containing pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif (APPL1)-mediated adiponectin and insulin-signaling pathways 51094 5163 26060 2475 388 7248 7249 PMC2647704__F5 Schematic of selenoprotein synthesis 4553 6503 118672 PMC2647780__F1 Signaling Logic of Activity-Triggered Dendritic Protein Synthesis 627 6009 1977 1938 PMC2651433__F2 A nuclear SIRT1 mechanism for delaying NAD-ATP depletion through inhibition of PARP-1 is presented 64802 23411 10135 PMC2651818__F3 Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network 2203 7167 2819 2820 5230 54707 51184 PMC2657110__F2 HIV-1 modulates the interferon-induced antiviral host mechanisms, protein kinase R and 2',5'-oligoadenylate synthesis 1998 6041 6035 PMC2657775__F7 Enrichment of TGF-beta signaling pathway 4089 3458 4087 1616 387 4838 PMC2657775__F9 Enrichment of Jak-STAT signaling pathway 2056 8027 5300 3569 PMC2657945__F1 The TSC-mTOR signaling 5728 5163 6446 7249 7248 6009 PMC2663056__F3 Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling 7124 1950 841 PMC2665873__F1 Fatty acid synthesis pathways in C 355 120114 2195 2196 79633 PMC2672430__F2 Prodeath or Prosurvival: Two Facets of Hypoxia Inducible Factor-1 in Perinatal Brain Injury 7428 664 4513 2056 3481 PMC2673242__F1 Loss of PTEN function results in accumulation of PIP3, which activates a cascade of signaling molecules 5163 2475 8178 5728 572 PMC2674015__F2a Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases 7099 114609 4118 4615 3654 29110 7189 7187 3661 PMC2675709__F5 Comparison of metabolites and transcripts in glycolysis, tricarboxylic acid (TCA) cycle, and pH-regulating pathways between the wild type (WT) and the stop1 mutant 4199 4200 2571 PMC2676108__F3 INHIBITOR OF APOPTOSIS (IAP) PROTEINS IN EUKARYOTIC EVOLUTION AND DEVELOPMENT: A MODEL OF THEMATIC CONSERVATION 8717 7186 8772 23118 5970 PMC2676730__F5 The Pathway Less Traveled: Moving from Candidate Genes to Candidate Pathways in the Analysis of Genome-Wide Data from Large Scale Pharmacogenetic Association Studies 5226 5228 1733 PMC2684656__F1 Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress 7018 22926 7186 83939 PMC2689776__F7 Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced Apoptosis in Non-small Lung Cancer Cells 355 3480 465 PMC2692251__F2 HuR and/or AUF1 differentially regulate mRNAs encoding cell cycle and Erk1/Erk2 Mapk signaling-related genes in MCT-1–transformed cells 126669 50964 6651 PMC2692400__F1 Hormone and nutrient signaling pathways modulating leptin translation 3667 7248 7038 6009 1999 PMC2696318__F1 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE 126669 2885 581 PMC2696318__F5 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE 4193 545 1839 5728 1847 PMC2696318__F6 ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE 5728 4193 1021 1019 PMC2696814__F1 Autophagy in the Pathogenesis of Disease 9776 7405 55626 83734 9140 9474 10533 64422 PMC2697290__F1 Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart 1080 4434 367 1179 PMC2697682__F1 Interaction of AEA with CB and TRPV1 receptors and its metabolism by FAAH and COX-2 7442 2166 4512 PMC2698322__F3 Complex relationship between PI3-K, mTOR and PKB signalling 5728 5163 253260 64223 2475 7249 7248 6009 PMC2704819__F2 Catabolic pathways encoded by the T 100188863 114569 5447 PMC2704867__F5 Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance 5728 5164 5163 1956 PMC2707261__F1 Regulation of glycolysis, glutaminolysis and de novo nucleotide biosynthesis in tumor cells 2539 7086 6714 3939 PMC2707511__F6 DNA Topoisomerase I Inhibitors: Chemistry, Biology and Interfacial Inhibition 55775 2067 146956 80198 4361 10111 672 9656 PMC2711774__F2 Proposed biosynthetic pathway for the disorazoles 55 53 1356 95 PMC2713346__F1 Crz1 enters the nucleus in short stochastic bursts lasting about 2 min after undergoing dephosphorylation in the cytoplasm by the calcium-activated phosphatase calcineurin (Cn) (, ) 63826 4772 4776 4775 4773 5966 1859 PMC2715810__F7 Model of PERK pathway controlling rRNA transcription and translation in comparison to mTOR 2475 83939 54700 11201 PMC2718504__F5 Predicted general metabolism and solute transport in T 8775 759 5447 283871 9242 PMC2728144__F6 Schematic diagram depicting our findings on the post-transcriptional regulation of CXCR4 in MCF7-HER2 cells as a result of estrogen and HER2 cross-talk and the involvement of activated PI3K and MAPK pathways and TSC2 (tuberin) 5266 7249 2475 1977 7852 PMC2732416__F5 Roles of the ILS pathway and HSF1 in aggregation toxicity and longevity 3479 5728 5266 3297 208 207 5163 PMC2735908__F8 Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway 65266 65125 6446 5164 1638 130497 PMC2736203__F2 Impact of a mixed microbial challenge on cell cycle control in HIGK 545 5020 472 5111 PMC2737270__F1 Autophagy pathway and machinery.A 79087 83734 29880 9140 10533 64422 PMC2738707__F1 Regulatory pathways in hepcidin expression 164656 148738 7391 6774 7392 10682 57817 PMC2753863__F1 Examination of Association of Genes in the Serotonin System to Autism 7166 121278 1644 15 PMC2757293__F2 Innate immune evasion by hepatitis C virus and West Nile virus 7297 3716 6772 7187 3661 PMC2764635__F1 The EGF activated ERK pathway: This is a schematic of the EGF activated ERK pathway beginning at the level of EGF binding to EGFR and finishing at the level of ERK; see the text for more details on the features and functions of the pathway 5894 2885 1398 1956 1950 PMC2764635__F3 New model of EGF activated ERK pathway: This is a schematic of our new model of the EGF activated ERK pathway which was developed from the original EGF model 5894 1956 1950 PMC2768581__F2 Role of Cross Talk between PI3-Kinase and ERK/MAP Kinase Pathways in Artery-Vein Specification 6469 2296 2050 PMC2770326__F6 Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures 2585 5973 6675 10020 2582 1798 8790 PMC2775177__F1 Branches of the UPR signalling pathway 22926 7494 83939 468 PMC2775805__F6 Molecular pathway analysis of genes regulated in the NAc by the HDAC inhibitor MS-275 after chronic social defeat stress 7039 148 1956 3716 5998 6773 6010 5978 PMC2778287__F6 Schematic representation of a dualistic model depicting the development of ovarian cancer 672 675 1956 673 3845 5728 PMC2782733__F2 EGFR signaling through the PI3K/Akt pathway 1956 1950 2885 2475 5728 PMC2788159__F1 Regulation of mTORC1 mTORC1 is a multiprotein complex composed of Raptor, mLST8, PRAS40, and FKBP38 and regulates protein synthesis and cell growth by phosphorylating S6K1 and 4EBP1 5163 7249 7248 6009 2475 1977 PMC2797409__F3 Reconstructed CCM of S 5640 2597 256356 5447 5183 1431 4397 PMC2798273__F1 Role of CobT in the late steps of AdoCbl biosynthesis 84890 351 4693 367 4827 PMC2799800__F1 Scheme of the model for the mammalian cell cycle 999 6502 991 PMC2803288__F4 Schematic diagram depicting the pathway via which GC-A signaling inhibits cardiac hypertrophy 5999 25801 2638 PMC2807132__F2 p38 signaling to the chromatin in muscle progenitor cells 3146 998 4209 PMC2810615__F1 Simplified overview of the canonical Wnt/Beta-catenin signaling pathway 4040 4041 1499 PMC2814418__F8 VDR-dependent and auxiliary pathways that lead to deltanoid-induced monocytic differentiation of myeloid leukemia cells 7421 10682 929 101180900 PMC2819006__F1 Key mechanisms involved in colorectal carcinogenesis 324 4513 1499 4292 4436 2956 PMC2820234__F3 Suggested signaling of the early stages of 1,25D-induced monocytic differentiation 7421 1020 1958 10682 929 PMC2820927__F3 Model illustrating the dynamic overlapping phases of early events of KSHV infection in endothelial and fibroblast cells and KSHV-induced signal pathways and their role in infection 100187761 6714 6010 PMC2821954__F2 Portrayed here is a molecular pathway analysis of genes regulated in the mouse nucleus accumbens by a direct infusion of the HDAC inhibitor MS-275 after chronic social defeat stress 7039 148 1956 3716 5998 6773 6010 5978 3437 PMC2824626__F1 Pathway for cholesterol synthesis from 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) by HMG CoA reductase and its inhibition by statins 650 998 387 5879 PMC2828273__F1 Interconnections between p53 and IGF-1/AKT/mTOR pathways 3486 5728 5163 5164 6009 4193 PMC2832126__F1 The multi-stage autophagic process 596 5728 5163 6009 55626 7405 9776 83734 9140 9474 10533 64422 PMC2833340__F1 Plane facts of PCP in the CNS 5754 7408 545 998 4920 115908 PMC2834542__F5 Actin cytoskeleton signaling pathway as represented by Ingenuity Pathway Analysis 1398 387 545 PMC2837985__F9 Proposed model for the regulatory mechanisms of the Ras and cAMP signaling pathways in stress response and antifungal drug susceptibility in C 998 4550 6053 6054 84057 2956 2928 11161 5317 PMC2839169__F1 Simplified illustration of the epidermal growth factor receptor (EGFR) pathway with the RAS/MAPK and PIK3CA/PTEN cascades 1956 5728 5594 2475 PMC2839261__F1 Effector pathways stimulated by Beta-ARs 1956 5602 5598 5597 9705 PMC2840217__F8 Alteration in Ubiquitin-Proteasome System (UPS) in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells 5066 367 8000 PMC2858431__F1 Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway 5728 7248 7249 6009 2475 1977 PMC2858667__F1 Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons 847 761 717 PMC2869518__F3 Proximal signaling events in the TCR-coupled signaling pathway 920 27040 3932 2885 998 PMC2871738__F3 Role of the major PD-associated genes in mitochondrial dysfunction 65018 581 10131 55486 PMC2872116__F1 Analysis of a protein interaction network in the context of the T-cell pathway 3932 5966 6300 100187761 2353 3725 PMC2872116__F2 Structuring protein interactions around familiar canonical pathways provides intuitive visualizations 3932 5901 4863 5966 PMC2872207__F4 Akt signaling pathway 2475 253260 5163 5728 6009 7248 7249 PMC2877394__F1 ER and SR interactions within mammalian cells 22926 6786 7494 596 7405 8408 3240 2475 PMC2880413__F2 Networks for (A) Biological network (B) Network MDL approach (C) PMDL approach The performance on the algorithms is performed on a biological data set 996 991 1105 9126 PMC2883511__F1 Signaling pathways and targets for LAM 5163 2475 6009 6010 1977 PMC2887331__F2 Serine/threonine kinase Akt, also known as protein kinase B (PKB), has become a major focus of attention because of its critical regulatory role in diverse cellular processes, including cancer progression 5728 2475 572 3091 PMC2890502__F2 The yeast MAPK signalling pathways deposited in KEGG 11043 998 27240 84188 PMC2890584__F6 Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling 5163 3094 5164 6714 PMC2896553__F6 DISTINCT SPECTRUM OF COPY NUMBER ABERRATIONS IN PAEDIATRIC HIGH GRADE GLIOMAS 4893 5185 23013 8000 472 PMC2896944__F3 Hsp90 shelters aberrant neuronal proteins 120892 65018 2932 367 PMC2897958__F4 Regulation of Lipid and Glucose Metabolism by Phosphatidylcholine Transfer Protein 7038 1376 7350 PMC2900889__F8 Possible fates of disulfide reduced SOD1 in the G93A/CCS mouse 6647 9973 1431 PMC2902905__F1 Sub-Cellular and Signaling Mechanisms Underlying Polar PIN Localization.A model of regulators and pathways contributing to polar PIN localization in roots is proposed based on results discussed in this review 5300 2794 51699 6642 PMC2908618__F7 Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomics Analysis 6387 7852 5163 5164 9261 2475 4046 27250 PMC2912657__F1 NFKB activation pathways 387 5966 6363 PMC2915755__F1 PCNA-coupled p21 degradation after DNA damage: the exception that confirms the rule? 338340 545 1642 PMC2919275__F2 PD-1 Pathway in Tolerance and Autoimmunity 940 5728 2475 PMC2919952__F1 Scheme of basic metabolic pathways and energy conservation in C 5805 2109 2108 7054 PMC2920482__F1 Detection of WNV and activation of IFNA/B genes and ISG according to the 2-step model 7297 3661 7187 3454 3455 PMC2921082__F1 Adenosine monophosphate-activated protein kinase pathway in hepatic fuel metabolism 3667 8660 7249 7248 2475 PMC2927527__F2 “Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress 22926 7494 83939 468 PMC2928307__F1 Plastids play a central role in the generation of wounding and herbivory induced signals 355 2717 4015 PMC2928642__F8 The PA-mediated activation of mTORC1 signaling 4018 5091 7249 7248 6009 PMC2930670__F2 Iron redox cycling in aerobic iron metabolism 3240 7018 2495 PMC2933389__F9 Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications 7248 7249 6009 2475 1977 PMC2936296__F2 RIG-I signalling pathway 4117 7054 7010 57506 6955 9140 5898 5970 4094 PMC2940266__F2 Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles 5728 572 324 1499 4193 2932 PMC2945208__F1 KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS 993 1021 1017 PMC2952191__F2 mTOR signaling pathway 5728 5163 7248 7249 6009 2475 64798 1999 1975 1977 PMC2954727__F1 Working model of the effects of E2 on cell migration 1956 6714 4838 7410 387 PMC2956119__F2 The many roles of FAS receptor signaling in the immune system 355 958 613 PMC2962793__F1 a, b Bioactive eicosanoids derived from the arachidonic acid cascade 4015 4512 4513 PMC2963059__F1 Canonical Wnt/Beta-catenin pathway 324 1499 607 PMC2971717__F1 Schema of the HER family signaling pathways 1956 2885 759 PMC2975945__F4 Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS 4049 4055 958 114609 3932 10454 5971 4781 5966 PMC2990540__F1 APC/C inhibition is regulated by signalling within the cytoplasm (a) and at the kinetochore (b) 991 27338 4163 57082 PMC2990976__F2 TNFA signaling pathways to NFKB activation 8717 7186 23118 10454 PMC2991541__F3 Redox-control of Matrix Metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease 7124 85451 4312 PMC2993245__F2 Negative regulation of junctional stability in RPE by the PI3K–ROS circuit 1956 1950 6714 999 5728 PMC2996902__F1 CoQ10 biosynthesis pathway 23590 57107 27235 51805 51004 84274 10229 PMC3012004__F2 Sites of action for inhibitors and shRNAs in the EGFR-PI3K-Akt-mTOR pathway 1956 5728 5163 3667 7249 7248 2475 253260 PMC3017908__F6 Major pathways affected in NMSC 2885 5728 6469 64399 409 51684 PMC3023470__F9 Schematic illustration of the sphingolipid metabolic pathway in CHO cells expressing SPHK1/2 and hSPNS2 124976 56848 8877 PMC3027010__F1 Schematic review of the molecular mechanisms linking diabetes mellitus and colorectal cancer 3479 2475 324 2885 PMC3031497__F7 Amplification of the 20q Chromosomal Arm Occurs Early in Tumorigenic Transformation and May Initiate Cancer 8480 10953 6227 11065 9217 PMC3031870__F1 MTORC1 and mTORC2 signaling branches 7249 7248 5728 6009 5163 PMC3032315__F3 Regulation of peripheral tolerance by the intrinsic and extrinsic apoptosis pathways in T and B cells 324 596 90427 613 PMC3032466__F11 Expression of cell cycle genes in wild-type (WT) and CKX-4 tubers after GA3-mediated tuber sprouting 324 991 7465 PMC3047613__F2 Model: The kinase IKK may activate Htt degradation by a mammalian version of the yeast Cvt pathway 6009 1020 140805 3064 23411 PMC3047798__F1 Ubiquitin-mediated regulation of the core Wnt pathway components APC, Axin and Beta-catenin 4041 4040 9958 324 1499 6477 8658 PMC3055758__F8 Mechanism of cAMP inhibition of MAPK activity 1950 7432 6714 PMC3058986__F8 Possible role of RACK1 in VEGF/Flt1-induced cell migration 7423 7422 5281 10399 5879 PMC3059306__F1 TSC mediated signaling in the central nervous system 2475 253260 64223 7249 6009 PMC3061277__F1 Simple schema of the IGF pathway and approaches to its inhibition 3479 3481 572 2475 PMC3069769__F1 Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy 5163 6446 3667 64798 5728 5594 5595 7249 7248 6009 1977 PMC3070572__F4 Schematic analysis of the regulatory pathways in BOO in AROM+/6J male mice 5728 5111 1281 PMC3071166__F3 Hypothetical scheme of the proposed mechanisms contributing to the induction of tolerance by SIT 920 114034 10342 PMC3071501__F10 Genes mapping to KEGG pathway for hedgehog signaling 6608 51684 51715 PMC3073545__F2 Endocannabinoids in Liver Disease 7038 355 4023 PMC3073693__F4 Molecular pathways in dystonia 22926 83939 55145 PMC3073741__F1 Complement and Viral Pathogenesis 718 1378 1380 727 720 735 729 2271 PMC3078497__F1 Effector signaling pathways activated during ischemia preconditioning 6774 2932 572 PMC3079294__F5 SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition 56852 5111 118027463 PMC3080858__F6 PDP-1 Links the TGFB and IIS Pathways to Regulate Longevity, Development, and Metabolism 3479 54704 5163 208 207 6497 PMC3083951__F3 A model (steps 1-4) for copper homeostasis in Schizosaccharomyces pombe (Schiz 10063 1353 6341 PMC3083963__F1 Brain-derived neurotrophic factor (BDNF) gene and stimulated intracellular signaling cascades after activation of tropomyosin-related kinase (Trk)B 627 126669 2885 2549 PMC3084054__F1 Synthesis-enabled functional group deletions to probe predicted intermolecular interactions involving the C41 carboxylic acid and/or the C19 mycosamine appendages of AmB 26136 81606 10 PMC3085544__F1 Intracellular signaling by the leptin (LepRb - cyan) and insulin receptor (magenta) 3717 9021 2885 6774 7249 7248 PMC308834__F1 A representative example of a plant pathway in MetaCyc 2695 100187761 4118 PMC3092286__F1 Nonlinear signaling through the PI3K-Akt pathway 5163 5728 6009 PMC309687__F10 Postsenescence survival in telomerase-deficient (tlc1Δ) budding yeast cells is controlled by three distinct Rad52-based homologous recombination pathways 10518 5893 10111 5888 PMC3098223__F1 Integrative Analysis of Transgenic Alfalfa (Medicago sativa L.) Suggests New Metabolic Control Mechanisms for Monolignol Biosynthesis 790 729230 1312 1230 PMC3098671__F2 Endoplasmic-Reticulum Calcium Depletion and Disease 22926 7494 83939 468 11261 PMC3100327__F1 De novo Biosynthesis of Biodiesel by Escherichia coli in Optimized Fed-Batch Cultivation 5132 95 8772 PMC3101847__F1 Pathways that regulate aging 7249 7248 6009 PMC3103318__F7 Model pathway for genistein-induced ASAH1 transcription in MCF-7 cells 4363 9429 427 9133 6667 PMC3104248__F1 MTOR signaling pathway 3667 5163 2932 7249 7248 6009 PMC3108053__F1 Fanconi anemia pathway and ICL repair: implications for cancer therapy 545 29089 472 55215 55120 2177 91442 80233 5889 PMC3108692__F1 Mammalian target of rapamycin (mTOR) network 5728 7249 7248 2475 6009 64223 PMC3109595__F5 Gene regulatory network model for specification of the skeletogenic mesoderm lineage 8092 4901 2078 3344 1112 PMC3109866__F1 Converging Pathways in Lifespan Regulation 9798 5163 7249 7248 5728 6446 253260 6009 PMC3111485__F5 A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1 2353 4351 5880 6651 9846 PMC3112285__F2 Pathway Crosstalk 5163 5728 2885 7249 7248 6009 PMC3113807__F5 The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans 207 6446 208 5108 5163 PMC3117856__F3 MAPK signaling pathway 4803 4351 1950 1399 2268 2002 2316 2353 4149 2645 355 51295 PMC3121446__F6 P53 activation by NML-MYBBP1A in response to glucose limitation 4553 10514 4193 PMC3121899__F3 Cartoons of PAR-1-dependent signaling by APC and thrombin in endothelial cells when EPCR is either free or occupied by protein C 5091 857 387 5879 PMC3124048__F1 Parallels in haematopoiesis between the Drosophila LG and mammalian bone marrow 474168 1000 100653366 PMC3124103__F1 Transcription factor NFKB regulates the cellular response to inflammatory and oxidant stress, as well as stretch 3383 5340 1958 PMC3130144__F6 Molecular mechanism of autophagy with synthesis of cathepsin D 22863 7405 9776 7098 54106 51284 PMC3132189__F4 Proposed lipid metabolic pathways in Giardia 5091 5064 283871 2821 PMC3132612__F2 The major signal transduction pathway in the ER stress response 7186 7494 22926 468 PMC3133616__F4 Functional network of ion channels in T lymphocytes 54822 324 7038 6786 84876 PMC3133824__F1 Cytonuclear signaling pathways in MSNs 4478 2002 6722 PMC3136902__F1 IL-1RI signaling 3553 54472 4615 59307 7189 10454 3725 3654 51135 3656 PMC3141028__F4 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation 8178 1636 11113 PMC3144426__F1 Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) 22926 83939 7494 468 PMC3148231__F12 MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus 867 3667 5728 PMC3148577__F3 A heterotrophic plant cells 4118 7408 11113 PMC3154047__F1 Activation of mammalian target of rapamycin complex 1 (mTORC1) 7248 7249 6009 64223 2475 PMC3155297__F1 General and organelle-specific stress response pathways influenced by the ageing process 83939 3297 3479 PMC3157841__F1 Expression Level Drives the Pattern of Selective Constraints along the Insulin/Tor Signal Transduction Pathway in Caenorhabditis 9798 208 5163 207 6446 PMC3159098__F2 Different RNA processing events in mammals 79042 80746 116461 283989 4553 57038 51091 118672 PMC3160197__F1 Crucial role of EGF signalling augments healthy lifespan in worms 1950 1956 2475 PMC3160786__F1 mTOR signaling pathway The scheme depicts mTOR signaling cascade in the regulation of energy and growth factor-dependent translation and autophagy 64798 7249 7248 6009 8408 1999 1977 PMC3161973__F1 Putative mogrosides biosynthesis pathway in Siraitia grosvenorii 4597 3423 100188864 1431 PMC316535__F6 Genetic models for ptp-2 signaling during (A) oogenesis and (B) vulval development 1950 1956 2885 PMC316921__F6 Wnt signaling in the early C. elegans embryo 474168 324 10940 PMC3170456__F1 Autophagy in Cancer: Therapeutic Implications 5728 5371 7249 7248 2475 9776 3920 64223 596 64422 9140 9474 10533 83734 PMC3170700__F1 Activation of cellular responses during ER stress 6402 22926 83939 468 PMC3172097__F1 Autophagy pathway in plants 9140 83734 22863 9776 PMC3172156__F2 RLR signaling pathway showing RIG-I bound to ligand RNA and signaling downstream to IRF-3 and NF-kB to induce IFNA/B production from a virus-infected cell 3716 7187 3661 PMC3175149__F1 IL-33 release and signaling via ST2L 90865 4615 7189 3654 PMC3176054__F5 Proposed model of early pathologic events occurring in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 male mice defined by changes in gene expression 3728 1829 1832 6714 PMC3177043__F2 Different pathways of myostatin signalling 3479 2475 2932 595 PMC3177754__F3 RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity 619537 7706 3661 PMC3180107__F1 Intrinsic and extrinsic pathways of apoptosis 8772 836 842 PMC3180573__F1 Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke 9817 8878 4094 PMC3181038__F1 Signaling the unfolded protein response: Three proximal sensors IRE1, PERK, and ATF6 regulate the UPR through their respective signaling cascades 22926 7494 468 PMC3187166__F1 Selected part of the central metabolism in C 5805 2597 2023 1431 PMC3187613__F5 Signaling pathways that regulate mammalian autophagy 5163 5728 7248 7249 6009 7405 572 PMC3187694__F1 Simplified model of autophagy 2475 10533 9140 PMC3191732__F11 Hydrolytic metabolism of 2-AG and PG-Gs 57406 26090 4512 PMC3192015__F1 Mammalian target of rapamycin, Akt, and phosphatidylinositol 3-kinase signaling 5163 7249 6009 253260 64223 1977 PMC3193426__F1 DSB repair pathways and SUMO 5111 56852 79677 23137 PMC3193469__F4 Simplified cartoons illustrating the components of the cullin–RING E3 ligases (CRLs) 6500 9978 8454 8452 991 1642 999 10297 324 PMC3193469__F6 Model of GA-induced DELLA protein degradation and the regulation of PIF protein function 6500 9978 8454 PMC3193496__F1 Two conserved branches of the canonical Wnt pathway 28996 6929 90196 10940 PMC3193940__F2 An array of cellular stressors can perturb the folding environment in the endoplasmic reticulum (ER) leading to unfolded or misfolded protein 22926 7494 7186 596 83939 468 1827 PMC3195649__F2 Targeted therapies for breast cancer 5728 5163 6009 PMC3196148__F9 Working model for the ATF4-dependent and c-JUN-dependent AA signaling pathways 83939 468 1386 PMC3196283__F1 BER pathways BER is initiated by a damage specific DNA glycosylase and APE1 that excise the damaged base and incise the arising abasic site, respectively generating a DNA single strand break with a 5'-sugar phosphate 5423 5111 7515 2237 PMC3198061__F3 In individuals with high macrophage aggregation around dead adipocytes as CLS, activation stimuli such as IL-1, lipopolysaccharide (LPS) and lipopolysaccharide binding protein (LBP), and TNFA bind to their appropriate membrane receptors 3929 929 7099 3667 4318 PMC3200485__F2 RGS14 at the interface of hippocampal signaling and synaptic plasticity 759 761 1950 3265 10636 60626 5662 PMC3203685__F1 Summary of the Proceedings from the 10th Annual Meeting of Molecularly Targeted Therapy in NSCLC 5163 7249 6009 253260 1977 PMC3214149__F3 Schematic overview of CagL and CagA-mediated signal transduction pathways involved in H 51665 1398 5879 1445 PMC3216277__F1 Within the intestinal lumen, the micellar solubilization of sterols facilitates movement through the diffusion barrier overlying the surface of the absorptive cells 3156 39 4547 64241 64240 95 7038 PMC3224393__F1 Reaction scheme for EGFR signal transduction pathway in H1299 cells 1950 867 1956 2885 PMC3228119__F1 PI3K/AKT/mTOR signaling network regulates cell survival, proliferation, migration, metabolism, and apoptosis, integrating the growth factor signaling pathway, nutrient status, and other oncogenic pathways 5163 3667 2475 5728 7249 7248 253260 6009 572 1977 27250 29904 PMC3228218__F1 HCG/MET signaling pathway 3082 2885 2549 998 5879 1398 2113 1021 572 PMC3229969__F2 Roles of FGF signaling in stem cell self-renewal, senescence and aging 10818 2885 2549 5163 4193 PMC3230307__F1 Autophagy regulation 5728 7249 7248 6009 2475 64223 PMC3230308__F1 Autophagy pathway and relationship to mTOR signaling 55626 7405 9776 2475 5728 5371 7249 7248 PMC3243113__F10 MULTIPLE WAYS TO DIE: DELINEATION OF THE UNFOLDED PROTEIN RESPONSE AND APOPTOSIS INDUCED BY SURFACTANT PROTEIN C BRICHOS MUTANTS 22926 7186 468 PMC3244904__F4 Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT 95 5091 907 3630 5662 283871 PMC3245550__F2 Arf Family G Proteins and their regulators: roles in membrane transport, development and disease 378 828 50807 377 381 400 375 8729 PMC3246074__F2 Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance 4615 1499 999 PMC3249073__F1 PtdEtn synthesis pathways in Plasmodium and yeast 4311 100379198 907 780904 5662 PMC3251006__F5 ECM-receptor interaction and focal adhesion pathway 923 3611 5728 573 126669 PMC3255271__F1 Study schema 6772 6774 9429 100187761 6418 PMC3258586__F1 PI3K pathway activated by EGF-stimulated EGFR or by the constitutively activated EGFRvIII 1956 6714 5728 2475 1950 PMC3259815__F8 Signaling through PAK in the hyperosmotic response pathway 5728 5163 998 PMC3262546__F1 The p14-p53-p21 and p16-Rb signaling pathways involved in fibroblast senescence 4193 1017 1019 PMC3278831__F4 Sample subnetwork formation 6010 4193 472 2934 PMC3281634__F1 Simplified diagram of the unfolded protein response 22926 7494 83939 468 PMC3281723__F2 Role of PHLPP in terminating oncogenic signaling pathways 5728 2475 4485 PMC3294214__F2 Signaling pathways regulating epithelial immune response in nematode epidermal (a) and intestinal (b) cells, adapted from Tan and Shapira 1257 208 207 6446 PMC3296242__F8 Models of interactions within the destruction complex (A) and the catalytic cycle of the destruction complex (B) 324 10297 1499 PMC3307000__F3 JNK signaling pathway regulates axonal transport and autophagy 351 2308 664 596 PMC3310713__F3 Dual nature of Myc induced DDR 4609 545 472 PMC3313080__F2 Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate 22926 2638 468 83939 85451 9140 PMC3315683__F1 Phosphatidylinositol 3-kinase signaling pathway 5163 8821 5728 6009 PMC3317017__F4 Altered signaling pathways and inhibitors 6469 5728 1956 6608 324 23385 51199 PMC3321453__F6 Vitamin D pathway and sites of interaction with dietary factors 5741 7421 1591 PMC3322527__F7 TGFB signaling pathway overlaid with differentially expressed genes 4838 6497 4092 7030 145258 PMC3323875__F3 Feedback inhibition mediated by the PI3K/AKT/mTOR pathway 3630 2885 3667 8660 2887 6009 7249 7248 2065 3480 PMC3328896__F2 Cbl-b functions as central gate keeper of T-cell activation 324 920 940 3932 2534 7535 5335 7409 PMC3329340__F3 Simplified TOR signaling network with known Arabidopsis homologs in Italic writing 5163 7249 7248 253260 64223 PMC3338780__F8 Receptor Tyrosine Kinases Activate Canonical WNT/Beta-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct Beta-Catenin Phosphorylation 8312 324 4040 1499 PMC3340193__F8 Scheme to explain the increased production of HA in fro/fro (NSMase2−/−) mouse fibroblasts 3037 5728 2475 5163 PMC3342071__F2 FcERI signaling events in WT, NTAL−/−, and LAT−/− cells 27040 9846 4067 2885 PMC3342643__F3 Diacylglycerol kinases in immune cell function and self-tolerance 940 5335 10125 8915 PMC3348846__F2 Leukocyte recruitment to sites of injury/infection: dominant role of ROS 7099 3146 7412 3383 PMC3356073__F1 Phosphatidylinositol 3-kinase (PI3K) signaling cascade 5728 253260 2475 7249 572 4193 7248 6009 PMC3357504__F3 Translation initiation control relays signals to erythroid and granulocytic differentiation 613 2475 6418 83939 1977 PMC3362297__F11 Proposed roles of the calcineurin signaling cascade in stress responses, drug tolerance, and virulence in C 4281 1255 5954 5955 PMC3364461__F1 Multiple transduction mechanisms induced at the FSHR 1956 2492 26060 1019 6194 PMC3365841__F16 GPCR-modulated channel activity in pituitary cells 2691 1392 7432 7200 2078 342538 PMC3367552__F6 Interaction map showing potential links between the Par proteins and components of the Hippo pathway 999 1499 64398 6010 PMC3368264__F1 An overview of the folate metabolism pathway in formation of essential intermediates in Leishmania 1719 2512 100187761 PMC3370224__F9 The ARF6 signaling pathway involved in HLHCGR internalization as deduced from the present study 382 2060 3973 PMC3374974__F2 EphA Receptor Signaling – Complexity and Emerging Themes 1969 5728 2885 5163 5879 7249 253260 2475 7248 6009 2002 PMC3375679__F2 Environmental regulation of GSC proliferation at developmental stages of the gonad 4843 5728 145258 22848 207 2619 7443 PMC3390632__F1 Overexpression of the Coq8 Kinase in Saccharomyces cerevisiae coq Null Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6 Biosynthetic Pathway 10466 84274 83548 27235 22796 91949 1392 7939 PMC3394800__F5 Developmental Changes in the Metabolic Network of Snapdragon Flowers 3652 56961 1431 PMC3400941__F1 Model depicting PI3K signaling 3667 5163 5728 2475 572 PMC3402097__F4 Lineage-specific and ubiquitous biological roles of the mammalian transcription factor LSF 1021 1019 1017 PMC3403522__F2 Intracellular HIF-1A regulation pathway in normoxia and hypoxia 1956 2475 7428 5163 3939 PMC3405730__F2 IL-2 signals by activating three principal signaling pathways, the SHC/RAS/MAP kinase pathway, JAK1/JAK3/STAT5 pathway, and PI 3-K/AKT/p70 S6 kinase pathway 3718 3716 2885 3560 3559 7018 PMC3405739__F2 The processes included in the insulin model 7499 5266 5728 PMC3407377__F2 TGFB signaling via TAK1 pathway: Role in kidney fibrosis 23118 7189 10454 1386 PMC3407651__F2 MEK/ERK signalling pathway in ALK+ ALCL 6009 2475 6194 3726 238 PMC3410580__F6 p62/SQSTM1 acts either as a pro-oncogene or as a tumor suppressor protein 2475 7189 1540 324 1499 PMC3413411__F1 PI3K-AKT-mTOR signaling pathway 3667 5728 5266 7248 5163 64798 64223 6009 2475 6446 PMC3414724__F2 Role of the PI3K pathway in B cell antigen presentation functions 613 5266 695 PMC3414727__F1 AKT/mTOR signaling pathway 3479 572 5163 5728 253260 7248 7249 2932 64798 64223 143686 2475 6009 9776 8408 1977 PMC3414727__F2 AKT/mTOR signaling and crosstalk with glycolysis and mitochondrial oxidative phosphorylation 7249 7248 3091 PMC3414811__F3 The mechanism of SLS 6908 83939 11231 PMC3416387__F5 Proposed metabolic pathways for central carbon and nitrogen metabolism in Y88 during glucose growth, based on protein identifications (dark gray ovals) and the presence of their corresponding genes in the Y88 genome 2539 1896 2597 3045 100187828 11113 4118 2271 6390 84365 5805 PMC3417165__F1 PI3K/AKT signaling pathway in Tregs 5728 5163 7249 7248 6009 50943 PMC3417373__F4 Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis 4282 2263 8772 5728 637 572 581 331 665 1959 PMC3422444__F1 AIDing antibody diversity by error-prone mismatch repair 4436 2956 5111 9156 PMC3430392__F1 The function of CETP in RCT.Notes: CETP mediates the equimolar transfer of CE and TG between atherogenic VLDL, LDL, and anti-atherogenic HDL 7038 4023 1071 PMC3430731__F1 Signaling pathways regulating lipogenesis in cancer cells 4118 4609 57103 92745 6510 2194 57016 2475 PMC3437536__F1 Class I phosphoinositide-3-kinase (PI3K) signaling pathway 5728 5879 2308 572 5163 PMC3438135__F1 Altered pancreatic beta cell mechanism silencing alpha and delta cells 759 1392 5266 7054 161823 3423 PMC3442422__F1 The Sre1 regulatory pathway 197131 8481 2078 PMC3442865__F1 TOR pathway activation 2475 5163 1977 PMC3461102__F1 Cell-Intrinsic Innate Immune Control of West Nile Virus Infection 7297 3716 51284 7098 6773 10379 7187 3661 PMC3464683__F3 Schematic representation of a plant cell with the major components involved in symbiotic signaling and defense signaling 28954 55746 79902 PMC3467044__F9 Model depicting the molecular underpinnings of lamin B2 origin licensing 54790 6996 4999 4609 990 81620 10873 PMC3469596__F8 Neutral lipid and phospholipid biosynthetic pathways 3949 5091 907 4018 7038 1071 5346 PMC3471537__F1 HER2 activation 1956 5728 5163 2885 PMC3474186__F4 Signaling pathways mediated by rat sarcoma (Ras) and protein kinase B (Akt) 5728 2475 4193 842 836 PMC3475172__F1 Model of canonical eukaryotic translation initiation pathway 100187761 1998 83939 PMC3475374__F1 Conceptual schematic of M 5447 4548 7808 PMC3479314__F1 SHEDDING NEW LIGHT ON NEURODEGENERATIVE DISEASES THROUGH THE MAMMALIAN TARGET OF RAPAMYCIN 7248 7249 6009 64223 2475 64798 PMC3490606__F1 Reactions involved in the flux of fatty acids into 355 5091 95 4018 5132 PMC3504431__F1 MTOR pathway 3667 5163 7249 7248 6009 64798 8408 2887 PMC3507479__F1 An expanded role of the tumor suppressor TSC1 in T cell tolerance 940 5335 5163 10125 7249 7248 6009 1960 1959 PMC3514454__F7 Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo 22926 6667 3383 PMC3517092__F1 Schematic depiction of the role of the retromer complex in mediating endosomal protein sorting 55737 51699 81609 8724 7879 PMC3519947__F1 Simplified diagram illustrating the mTOR signaling pathway 5662 5163 2475 PMC3520045__F4 Summary diagram of Nrf2 and HIF1 stimulation in presence of oxidative stress 9817 7428 6647 2056 PMC3520610__F2 Targeting the TGFB signalling pathway in disease 6010 7189 9618 3725 4089 29102 PMC3521387__F7 ILOCi detected genes from BD and their maps in 'neuroactive ligand-receptor interaction' pathway 799 3356 4018 3953 5327 5617 PMC3533361__F1 GSK3 signaling in neural development 4040 4041 998 5728 27185 324 PMC3536343__F4 MAPK signaling to the translational machinery 1977 1975 5163 6194 7249 29904 7248 6009 1938 64798 PMC3543073__F4 Bacterial nucleomodulins targeting chromatin 1536 4152 22893 PMC3549672__F3 Ubiquitination in Signaling to and Activation of IKK 8915 10892 7189 23118 PMC3554122__F1 Summary of checkpoint factors 4360 9184 5884 PMC3554769__F1 Mathematical Model for MicroRNA in Lung Cancer 4609 8091 999 PMC3558870__F1 The potential disruption of hepatic GH signaling pathways by MC 2690 3667 3717 2885 9021 PMC3561014__F2 Adjustments in root metabolism promote acclimation to deficiency 4397 100271695 5183 717 1431 4524 PMC3562086__F1 Connecting the Insulin pathway to the Drosophila autophagy machinery 253260 7249 6009 9474 64422 83734 9776 10533 9140 PMC3562414__F2a Surfactant phospholipid metabolism 5091 10400 283871 5662 PMC3567494__F1 Two phosphoinositide cycles regulate aspects of lysosome function 5091 5053 79443 5266 3552 9896 200576 PMC3570922__F1 PI3K/AKT/GSK3/mTOR signaling 5728 2475 1499 PMC3572003__F1 Altered energy metabolism in cancer 4609 5728 3939 5163 PMC3573143__F2 Regulation of autophagy in response to stress 5728 5163 7249 7248 83939 6009 2475 468 9140 664 PMC3573943__F1 Regulation of cellular metabolism by p53 2539 27165 2593 9997 57103 5164 PMC3575813__F10 Presence of a diversity of Alu-mediated events in genes involved in apoptosis 355 8772 8717 7186 637 2021 4615 572 472 PMC3577660__F8 Regulation of proteins translation in Jurkat cells 2475 1977 1975 8661 1999 PMC3577986__F6 Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy 183 7532 351 4397 3827 219771 4026 5996 PMC3582104__F1 The intracellular signaling pathways modulated by somatostatin receptors 6750 6714 581 PMC3585156__F5 Net Expression Inhibits the Growth of Pancreatic Ductal Adenocarcinoma Cell PL45 In Vitro and In Vivo 1019 1017 6722 PMC3591604__F2 GPI anchor synthesis 9091 5283 5279 8818 9487 284098 93183 84720 5281 10026 80055 PMC3599951__F5 Phytochemicals targeting NFkB signaling pathway 5728 637 572 PMC3603147__F7 Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells 11113 23178 130497 PMC3606625__F1 EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance 1956 3717 5728 6774 2475 1869 5111 PMC3608184__F1 Cardioprotective mechanisms of T3 6955 4312 2475 3091 PMC3611005__F10 LKB1-SIK2/3-class IIa HDAC pathway as a novel signaling module 23235 23387 9759 10014 51564 200186 PMC3616052__F5 Differentially Expressed Genes during Contrasting Growth Stages of Artemisia annua for Artemisinin Content 3423 3652 8213 PMC3618314__F7 Characterization of CP genes in relation to the canonical TGFB signaling pathway 6955 735 4838 PMC3618441__F1 Membrane-initiated Actions of Estradiol that Regulate Reproduction, Energy Balance and Body Temperature 5335 3717 6774 PMC3623255__F2 Mass isotopomer labeling measurements of intracellular metabolites (red bars, after 8.0 h in growth phase I; green bars, after 14.25 h in growth phase II) arranged by pathways: fractional abundance over mass in context of the metabolic network 10020 6120 1896 283871 2717 4118 PMC3625859__F3 Regulation of angiogenesis by microRNAs (miRNAs) 4609 9146 161742 51684 PMC3627065__F6 Integrated view of mammalian autophagy 596 55626 9140 9474 7405 22863 10533 83734 64422 PMC3627065__F8 Factors situated at the interface between the ubiquitin-proteasome and the autophagy-lysosome degradative systems 573 9531 2475 PMC3636752__F1 Distinct activation pathways for different CDKs 983 1017 7465 1022 4661 1019 PMC3636756__F1 Two kinases are required to promote mitotic entry 7465 4661 983 PMC3636756__F3 CSF arrest is the result of a tight balance between PP2A-B55 and PP2A-B56 10776 983 324 PMC3638465__F1 Metabolic map showing selected pathways of D 2242 6503 867 PMC3638721__F7 TRAIL-activated proapoptotic and antiapoptotic pathways 8772 836 637 PMC3650616__F9 MEK inhibition increases lapatinib sensitivity via modulation of FOXM1 1956 2305 2475 PMC3652374__F2 Insulin signalling exerts rapid stimulation of glucose transport as well as fatty acid uptake, synthesis and esterification to triacylglycerol (TG) 355 4023 7038 PMC3656004__F11 Acetylcholine Promotes Ca2+and NO-Oscillations in Adipocytes Implicating Ca2+→NO→cGMP→cADP-ribose→Ca2+ Positive Feedback Loop - Modulatory Effects of Norepinephrine and Atrial Natriuretic Peptide 5728 952 7225 7222 PMC3660828__F2 Biosynthetic pathways of aminoglycerophospholipids 5091 5662 10400 100379198 PMC3660828__F3 Components involved in translocation of phospholipids to and within mitochondria of yeast 5245 11331 283871 9489 1040 91419 5091 PMC3666557__F2 Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration 22926 468 83939 PMC3667713__F4 Molecular Rheostat at the Interface of Cancer and Diabetes 1956 8826 5163 PMC3672663__F1 The canonical Hedgehog signalling pathway in mammals 6608 64399 51684 2619 91653 PMC3672773__F1 Schematic presentation of select miRNAs that regulate toll-like receptor signaling pathways 7100 7099 54106 51311 51284 4118 7098 4615 3656 7189 7187 10454 3663 23118 29110 27250 3665 3661 3569 PMC3674226__F3 Where No Synapses Go: Gatekeepers of Circuit Remodeling and Synaptic Strength 5728 387 2475 PMC3675946__F6 Cell wall integrity (CWI) signaling pathway with transcriptomic expression changes during limonene stress 11043 2928 6094 116844 5230 PMC3679383__F1 Pathways of GPL biosynthesis in eukaryotic cells: temporal regulation of GPL-synthesizing enzyme activities 4099 4018 5764 283871 10400 5091 5662 PMC3680926__F1 Estrogen receptor functional domains and signal transduction schemes 100187761 7018 208 PMC3681689__F6 Working model for the roles of the mitochondrial chaperones Ssq1-Jac1 and the glutaredoxin Grx5 in Fe/S protein maturation in eukaryotes 9054 200205 27247 PMC3688698__F3 The mTOR Pathway in Hepatic Malignancies 9776 2475 1977 PMC3688817__F8 PPARB Regulates Liver Regeneration by Modulating Akt and E2f Signaling 983 1019 47 1017 PMC3690356__F1 Calcium channels in T cells 324 857 6786 PMC3694976__F10 Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia 867 2056 8027 5292 3569 PMC3700115__F7 Known and novel roles of the p38-MK2/3 signaling pathway in cross-striated muscles 7018 4899 1958 6667 PMC3712188__F2 Inducing autophagy by inhibiting the mTOR pathway.mTOR is a downstream effector of the class I phosphoinositol 3-kinase (PI3K) pathway 7248 7249 6009 64223 8408 9776 PMC3712188__F3 Autophagy and polyglutamine diseases 5912 596 3630 PMC3715494__F2 A Lover and a Fighter: The Genome Sequence of an Entomopathogenic Nematode Heterorhabditis bacteriophora 3479 9798 5163 6446 207 208 414301 PMC3715701__F1 Myosin 1c in cellular signaling pathways 998 6714 5879 1487 5058 3667 PMC3726950__F2 Regulation of autophagy pathways and targets for modulating autophagy by drugs/compounds 759 1956 6009 3630 2475 PMC3729625__F2 Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling 7249 7248 6009 8408 9474 9140 10533 83734 64422 PMC3730427__F8 Glucose deprivation in cancer cells activates UPR following HBP flux reduction 22926 1965 7494 468 596 PMC3735949__F6 Changes in the genes and processes related to mitochondrial metabolism in RAW264.7 and TGEM cells treated with KLA 355 1376 171425 PMC3739146__F7 NAC protects against Cd-induced germ cell apoptosis by inhibiting UPR signalling in the testes 914 22926 83939 7494 PMC3744367__F1 mTOR couples cellular nutrient sensing to organismal metabolic homeostasis 7248 6009 7249 2475 64223 PMC3744901__F9 Regulation of RB/E2F pathway 1019 1950 5728 4193 PMC3752265__F5 Example of differences in use between glycolysis and the ED pathway by representative cells in our modeled population 6120 1896 197257 PMC3753504__F28 Influence of hepatocyte culture conditions on signaling and phenotype 6714 4087 4088 PMC3756396__F1 Simplified scheme of the possible involvement of cAMP/PKA pathway in cancer 4193 6469 596 PMC3757428__F2 Growth factors mediated mTORC1 and mTORC2 activation 5163 7249 7248 6009 PMC3760546__F4 Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease 7018 7035 5340 2161 PMC3770093__F1 Sphingolipid biosynthetic pathway 51083 57704 2629 PMC3771549__F1 Role of Nox-derived ROS in Ang II-mediated effects in vascular cells 367 3717 387 PMC3774138__F1 Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer 5163 3667 8491 5728 7249 7248 572 6009 27250 29904 1977 PMC3774138__F2 Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer 2885 5728 5163 572 7249 7248 6009 1977 PMC3791171__F2 Molecular pathogenesis and mechanisms of thyroid cancer 5163 5728 2309 2932 2475 1499 PMC3791603__F1 Hh signaling in animals 6608 84976 6497 51684 PMC3793031__F2 Symbiotic signaling downstream of oscillations 4609 2081 51199 PMC3809361__F1 Metabolism of cancer cells is regulated by signaling pathways related to oncogenes and tumor-suppressor genes 5728 57103 2475 4609 9997 PMC3813872__F7 Models of Eph signaling in amphid axon guidance 25 5728 6446 5163 207 PMC3818951__F1 Osteoclastogenesis 5925 7189 4286 1513 100187907 PMC3821079__F1 Schematic representation and overview of PI3K/AKT/mTOR/PTEN signaling 5728 7249 7248 2475 1499 PMC3821079__F3 Several inhibitors linked to the PI3K/AKT/mTOR/PTEN signaling pathway are shown 5728 7249 7248 2475 1499 PMC3823475__F2 Membrane VEGF receptors expressed by astroglial tumour cells 5281 2638 3791 PMC3824660__F2 Interrelations between autophagy-related signaling and cell growth control in response to stress 3667 5728 5163 7249 7248 6009 83939 468 2475 664 PMC3829599__F1 mTOR pathway signaling cascade 7249 7248 6009 3667 2887 5163 2000 PMC3836044__F1 Canonical (Wnt/Beta-catenin) pathway 22943 324 84720 1499 PMC3836323__F2 Vascular smooth muscle cells mechanotransduction mechanisms in stretch-dependent interconnected signalling 3479 387 5879 PMC3839612__F5 A detailed model of the Rad5-mediate template switch pathway, assuming gap filling dependent on a subset of HR functions after the replication fork has passed 5111 5888 118027463 56852 80010 PMC3843070__F5 Model illustrating the potential role of CRKL in recruiting NleH1 to inhibit RPS3/NFKB signaling during A/E pathogen infection 7124 23118 10454 1399 6188 PMC3845023__F1 Sulfate assimilation pathway 9060 9061 10380 10237 347734 PMC3855043__F5 IPA pathways of ChIP-Seq-based NSRF target genes in ESC 2885 6908 2002 PMC3855091__F6 Foxa2 deletion leading to premature aging and age-onset obesity 3170 6777 3661 2475 54541 57761 143686 7248 PMC3870072__F5 Subnetworks 1, 2, and 4 of 9 networks in baicalin group 5901 5979 2353 5970 4117 6667 5076 PMC3870290__F1 Proteolytic processing of the amyloid precursor protein (APP) and Notch 351 23621 3416 PMC3870290__F4 Potential mechanism of AICD-mediated gene regulation 351 3416 718 3929 9968 PMC3871617__F5 NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria 8862 2040 857 858 859 613 952 PMC3871878__F2 Hypoxia inducible factor pathway inhibitors as anticancer therapeutics 2475 7150 7428 PMC3876738__F2 Therapeutic targets in cancer cell metabolism and autophagy 2475 9776 9140 10533 9474 64422 83734 PMC3877826__F9 Model of Interaction with the b-Dependent Developmental Control Pathway.(A) Filamentous growth is triggered by bE/bW-dependent induction of rbf1 expression 10519 10978 5551 PMC3880197__F2 Reactive oxygen species in cancer 5728 5879 6714 5163 PMC3880546__F2 Pathological regulation of the mTOR pathway in neurological disease 92335 5728 7248 7249 6009 1977 PMC3881016__F5 Pathway analysis of iron deficiency associated chlorosis 1311 3398 91734 PMC3886813__F1 NFKB and STAT3 signaling in glioma: targets for future therapies 6007 5971 367 PMC3887408__F1 Interactions of the Ras/PI3K/PTEN/Akt/mTOR and Ras/Raf/MEK/ERK pathways with GSK-3 2885 3667 4763 5728 5163 7249 7248 6009 64798 2475 8408 6194 1977 PMC3887879__F1 MTOR signaling pathway 64798 7249 51256 7248 6009 PMC3887911__F3 Interacting partners and posttranslational modification of Orai1 and STIM1 84876 6786 84766 6836 983 PMC3888279__F3 Regulation of hypoxia-inducible factor (HIF)–A expression or stabilization by pathways other than hypoxia 5979 3480 1956 7341 8453 4193 9978 PMC3888876__F2 MONOGENIC AUTOINFLAMMATORY DISEASES: DISORDERS OF AMPLIFIED DANGER SENSING AND CYTOKINE DYSREGULATION 7297 3716 3717 114548 7124 79092 8915 10892 PMC3889251__F1 BMP2 signaling pathway resulting in osteogenesis or adipogenesis 650 657 10454 7018 1386 PMC3890716__F2 Schematic for the putative biosynthetic pathways of three major classes of active compounds in I 412 3652 1230 790 275 1644 PMC3891587__F2 GENETIC CONTROL OF CANDIDA ALBICANS BIOFILM DEVELOPMENT 1442 59272 128 253 378427 1889 23481 3084 79902 PMC3893888__F4 Signal transduction pathways leading to increased HIF-1A protein levels 7249 7248 6009 PMC3893993__F3 RAS-mitogen-activated protein kinase signaling pathway 2885 9846 8036 161742 PMC3899918__F2 Jak-STAT Signaling Pathway from KEGG (ID: hsa04630) overlaid with log2 fold change values using PathVisio indicating up (red) or downregulation (blue) following ART 867 2056 8027 PMC3903477__F1 Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways 84890 95 53 52 PMC3906332__F4 Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells 6657 3643 2475 PMC3910500__F6 Canonical PI3K and MAPK pathway activation determined by reverse phase protein arrays and compared between GBM subclasses: Proneural (P, purple, n=55) and Mesenchymal (M, red, n=45) 3667 5163 7249 7248 1977 PMC3921549__F1 Carcinogenetic pathway and classification of colorectal cancer 673 387569 3845 324 PMC3924811__F2 Mechanosignaling in Bone Health, Trauma and Inflammation 6714 4513 2353 3725 860 PMC3926505__F3 Roles of Cu in synaptic function 5662 538 475 PMC3926670__F4 Enriched pathway of the target gene union of radiation-response miRNAs 5728 4824 367 1017 572 596 4703 2475 PMC3930975__F1 The unfolded protein response pathway 7494 468 22926 PMC3936289__F4 Major crosstalks between the PI3K and the MAPK cascades 3667 2885 5163 7249 2475 253260 1977 4609 PMC3938170__F1 Folate pathway 2348 1719 635 4397 4524 875 PMC3943494__F3 Ceramide Metabolic Pathway in Epidermis 29956 64781 6611 340451 PMC3953715__F1 PI3K/PTEN–mTOR pathway 5728 5163 6009 PMC3955168__F3 The unfolded protein response (UPR) pathway and its chemical modulators 22926 7494 83939 468 PMC3956512__F1 The unfolded protein response (UPR) pathway in Cryptococcus 22926 7494 83939 468 PMC3959213__F1 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway 2597 2539 2821 7086 226 2023 PMC3959213__F6 Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway 2539 2821 226 2597 2023 PMC3967167__F1 Schematic drawing of the PI3K/Akt signaling pathway 5728 5163 7249 572 PMC3969788__F4 Strategies for Delivery of Therapeutics into the Central Nervous System for Treatment of Lysosomal Storage Disorders 3383 6010 8411 6714 3916 PMC3972652__F1 Biosynthesis pathway for gangliosides 9331 6489 8705 283459 51083 PMC3973207__F8 Schematic diagram showing differences in the thyroid cancer cell lines sensitive or resistant to apoptosis 581 637 572 PMC3978635__F1 mTOR pathway and actions 5728 2475 7249 7248 PMC3982775__F1 Structure of the systems model of type C4 photosynthesis 2695 3250 25801 8213 4118 PMC3983448__F4 Human epidermal growth receptor family members, the PI3K/Akt pathway, and targeted drugs 1956 3480 5728 2475 4513 1233 PMC3985726__F47 Canonical (yellow background) and non-canonical (red background) Wnt/Beta-catenin signaling pathways are related to mechanical elements and actions responsible for cell polarization, migration and tissue organization 8826 324 6010 PMC3986808__F2 Copper is passed (green arrows) to cuproproteins (dark green circles), including metallothioneins Crs5 and Cup1, in for example Saccharomyces cerevisiae, by copper metallochaperones (pale green circles, or ovals if membrane associated) 6647 9973 6341 4513 4512 1353 10063 PMC3987972__F3 Intracellular signalling pathways mediated by HLA class I or II antibody binding to endothelial cells 6010 1654 9972 1973 338376 7038 PMC3992631__F3 Comparison of gene expression in immobilized relative to planktonic yeast: (A) intermediary metabolism and (B) cell cycle 116629 997 5230 2026 2023 5132 4191 4190 128 127 50 3417 3418 PMC3994321__F1 Autophagic pathways in mammalian cells 2475 7405 9140 10533 83734 9474 64422 PMC3998676__F1 ADVANCING AGE IS ASSOCIATED WITH GENE EXPRESSION CHANGES RESEMBLING mTOR INHIBITION: EVIDENCE FROM TWO HUMAN POPULATIONS 3667 5163 5728 7249 7248 6009 6774 8408 6446 3665 10397 PMC4001855__F1 Glycosylation of the nuclear pore 6675 8473 10724 PMC4002321__F2 PI3K/Akt pathway involved in tumorigenesis 5728 572 595 1977 PMC4005015__F9a DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES 7428 5163 3939 PMC4007928__F1 Key features of the phosphoinositide 3-kinase (PI3K) signaling pathway 5728 5163 7249 7248 572 4193 6009 PMC4010202__F2 Proposed signaling mechanisms underlying the protective effects of mood stabilizing drugs against experimental stroke 6667 7852 627 9242 PMC4011959__F3 The initial stages of vesicle elongation in macroautophagy 9474 83734 9140 10533 64422 PMC4015186__F4 Insights into MiRNA Regulation of the Human Glycome 84890 28 2524 2592 PMC4016715__F2 Ciliary-vesicle-dependent steps of ciliogenesis, and modular organization and mechanism of the IFT machinery 7175 4827 55764 9742 112752 7289 582 585 55212 27241 129880 51098 51668 56912 90410 80173 55081 57560 26160 28981 8100 64792 376267 51552 201475 PMC4026357__F1 Importance of Breast Cancer Subtype in the Development of Androgen Receptor Directed Therapy 367 1499 2065 PMC4026697__F3 VKR signaling pathways 5163 6461 2885 2475 PMC4028840__F1 PI3K/Akt/mTOR signaling pathway ] 5163 5728 3667 6009 7249 7248 PMC4030844__F1 Simplified schema of interconnections between small ubiquitin-related modifier (SUMO) pathway proteins and other factors regulating androgen receptor (AR)-dependent transcription 29843 59343 6612 26036 367 3065 1616 9759 PMC4031983__F8 MiRNA dependent regulation of DSB repair during cell cycle 672 5888 55364 675 PMC4032270__F3 Oak Root Response to Ectomycorrhizal Symbiosis Establishment: RNA-Seq Derived Transcript Identification and Expression Profiling 1431 2147 100306940 7018 4602 367 PMC4035704__F3 Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP 2308 6009 7249 7248 PMC4036234__F2 Cargo recognition and packaging in selective macroautophagy 8504 3964 8878 10133 10241 PMC4036317__F11 How PLCG1 regulates USP1 phosphorylation to mediate 20E-induced gene expression for metamorphosis 5335 8558 7398 PMC4037363__F3 Trafficking of endosomal Toll-like receptors 7939 10533 4615 3665 PMC4038907__F4 Progesterone and breast cancer 1950 2885 1017 6667 595 PMC4042208__F1 Stress signaling pathways activated by electrophiles 9817 22926 83939 468 PMC4044302__F1 Sites of thyroid hormone regulation of metabolism 6774 355 7200 7350 389692 2309 3949 1581 PMC4048575__F1 Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival 9776 60673 7405 10533 9140 83734 9474 64422 PMC4048575__F5 Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival 9817 8452 4094 56954 PMC4054275__F11 Proposed regulatory mechanism of protein tyrosine phosphatases in C 2078 7018 466 PMC4055840__F5 Hypothetical model illustrating possible molecular mechanisms underlying the action of the glucocorticoid receptor in the excitation-inhibition balance in NPCs 1958 627 1325 PMC4065255__F1 Core components of the insulin-like signaling pathway in C 6446 208 207 5163 9798 PMC4066219__F2 IL-15: a central regulator of celiac disease immunopathology 3718 920 50943 PMC4066235__F4 microRNAs in Cancer Cell Response to Ionizing Radiation 3014 472 545 693122 4193 993 1019 1017 PMC4066235__F5 microRNAs in Cancer Cell Response to Ionizing Radiation 3014 472 545 693122 4193 993 983 891 723778 7465 PMC4066991__F1 Missing Link between Itch and Inflammation in Atopic Dermatitis 6786 85480 8989 83737 PMC4074565__F1 Regulation of mTORC1 by amino acids 54468 81929 84219 6396 10641 2695 55004 201163 96459 PMC4075091__F5 Domain structure of p62 and its interacting partners 7189 9817 4077 PMC4076814__F6 Diagram depicting the role of GPX7 in regulating inflammation in esophageal epithelial cells 2882 7186 8717 2919 PMC4076981__F8 Schematic drawing of the current model for the interrelationship between nutrient and light signaling in T 95 55023 2782 PMC4076992__F2 Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease 7186 83939 7494 468 22926 PMC4077447__F2 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy 353 4507 4548 PMC4087161__F2 Phosphorylation of Foxo1 at S253 by Akt promotes Foxo1 cytoplasmic retention and ubiquitination, which serves as a central mechanism controlling Foxo1 stability and activity () 3276 1859 4485 22933 PMC4095756__F2a GRK2 – A Link Between Myocardial Contractile Function and Cardiac Metabolism 2885 3667 2475 PMC4107035__F3 PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA 2885 5728 10617 4763 5163 92335 7248 6009 2475 PMC4114208__F1 Unfolded protein response pathways are shown 7494 22926 468 PMC4114321__F3 Regulation of homologous recombination in eukaryotes 10518 1201 117286 130106 675 5888 472 545 84126 5111 PMC4118249__F9 Theoretical structure of this triple-hit nALI model as a translational study 4615 7099 374 PMC4122337__F2 Potential roles of GPR120 and its agonists in the management of diabetes 7097 114548 10454 3553 PMC4128044__F2 MTOR pathway as a therapeutic target 5163 7248 7249 6009 PMC4128856__F7 Targeting c-Met in melanoma 3082 7249 6009 2475 2627 324 PMC4134689__F2 Therapeutic strategies to target mutant NRAS: Direct targeting strategies include inhibition of RAS transcription by RNA interference and blockade of posttranslational modification by farnesyltransferase inhibitors 4893 1029 5728 1019 2475 PMC4135580__F7 Working model for the PEX5L-PEX7-mediated import pathway 5191 5830 5189 9409 5190 PMC4138046__F1 Multi-Level Kinetic Model Explaining Diverse Roles of Isozymes in Prokaryotes 183 25801 3250 7086 2821 PMC4139891__F1 In renal cancer cells, stem cell factor (SCF) binding to the c-Kit receptor (c-KitR) induces several signal transduction pathways that lead to its proliferation, invasion, survival, and angiogenesis 5155 126669 4067 2534 8453 4738 6774 5879 23440 5728 2475 PMC4142219__F3 Characterization of glycoproteins in pancreatic cyst fluid using a high performance multiple lectin affinity chromatography platform 885 279 280 1506 387 5879 5406 4036 1080 PMC4146642__F7 ABeta(1-42) oligomer-induced oxidative stress 5300 768 367 PMC4148087__F4 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention 3479 3480 5728 PMC4148087__F7 Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention 472 4193 595 675 672 PMC4149734__F5 Turnover of proteins in metabolic pathways in barley leaves 7808 5447 283871 3250 PMC4150436__F2 miRNAs involved in angiogenic process 9146 51684 7422 961 5296 5728 8453 2475 PMC4156617__F1 Updated working model for the AR showing a bifurcated signaling pathway downstream of cAMP/Epac 4827 4905 367 PMC4157394__F13 Apoptosis pathways affected by rocaglamides 8772 637 581 PMC4165418__F3 AKT's role in the NER pathway 7507 2067 5111 PMC4169452__F2 An Integrated Ontology Resource to Explore and Study Host-Virus Relationships 100187761 57506 7054 7706 4827 57762 PMC4178426__F9 Vascular smooth muscle contraction pathway 5966 27040 100187761 5979 PMC4183827__F9 Proposed DAT/PAT, sulfolipid, and phthiocerol dimycocerosate biosynthetic pathways 63928 4352 4326 367 11261 8103 338333 PMC4191248__F2 Pancreatic cancer pathway diagram page 5728 1950 7039 2735 3845 208 50636 PMC4191248__F3 Hypoxia-inducible factor pathway 55662 10956 2033 7428 6303 275 112483 PMC4192457__F2 Signaling pathway regulation of autophagy by several factors 2475 8408 9776 664 7405 22863 PMC4196580__F9 Chemokine signaling pathway showing the annotated and non-annotated proteins 7959 126669 5966 1794 9844 3702 29984 1398 PMC4197858__F2 Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease 22934 2539 7086 5209 6120 6611 6723 PMC4197858__F3 Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease 367 2539 2739 387 1719 4524 3156 29914 PMC4209143__F2 Macroautophagy is regulated by several signalling pathways 790 3630 759 796 6009 64798 64223 PMC4224453__F10 miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells 23035 5728 5879 998 PMC4230782__F9 The role of Pkp3 in cell–cell junction formation 11187 5318 387 PMC4235299__F1 Genes for which a correlation with Wnt/Beta-catenin signaling was indicated by MetaCore pathway analysis 324 154043 9968 892 PMC4240281__F4 Molecular mechanisms of epithelial–mesenchymal transition 5727 6608 3611 7189 2885 2932 6774 PMC4243516__F1 Signaling partners of the p75NTR 4803 4099 4340 387 7189 84894 PMC4248747__F8 Proposed model for the control of Beta-catenin stability by RNF220/USP7 55182 7874 1499 324 PMC4249544__F3 Central carbon metabolism, including glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle 11113 4118 2353 PMC4250281__F1 Cellular signaling through pre-organized and inter-connected nanocluster assemblies with gel-like properties 2885 1956 2475 6285 5879 324 1499 999 998 8826 PMC4261029__F1 Schematic illustration of the mTOR signaling pathway, including major upstream regulators and downstream substrates for both the mTORC2 and mTORC1 kinase complexes 3667 5163 5728 6009 7249 7248 51256 253260 64223 2475 PMC4263413__F1 Transcriptome Profiles of the Protoscoleces of Echinococcus granulosus Reveal that Excretory-Secretory Products Are Essential to Metabolic Adaptation 2539 226 2597 PMC4267808__F4 The Shared Crosstalk of Multiple Pathways Involved in the Inflammation between Rheumatoid Arthritis and Coronary Artery Disease Based on a Digital Gene Expression Profile 1055 6955 2023 109245082 PMC4268391__F1 RTK-PI3K-AKT signaling pathway 3480 5728 7249 7248 6009 4609 2475 PMC4270133__F5 Applications of DRS 3651 3845 8205 PMC4276806__F2 Proposed pathogenic mechanisms of Alpha-syn-related Lewy body formation in PD 120892 65018 248 PMC4278616__F2 Signaling modulating adherens junctions (AJs) 5879 1003 387 6010 PMC4286324__F1 Membrane dynamics and the endocytic pathway 10938 30845 83547 PMC4286365__F1 Biosynthetic and recycling routes in MDCK cells: the new paradigm 367 3949 5284 PMC4291019__F6 ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock 4615 382 3661 114609 PMC4291754__F4 Cell signaling pathways are allosterically elicited by the activated receptor tyrosine kinase (RTK) 2885 4193 2308 PMC4295378__F3 The WNT signaling network on cancer cell metabolism 2932 324 7249 7248 1499 PMC4299512__F1 Select upstream regulators and downstream effectors of mTOR signaling 5728 5163 2932 7249 7248 6009 6446 PMC4301714__F1 Simplified model of the Rag4-KlRgt1 glucose signaling pathway controlling RAG1 gene expression 5896 7504 2023 2026 PMC4304082__F1 Piece #1: Tumor suppressor and oncogenic pathways converge on the mitochondrial pathway of apoptosis 5728 842 4193 4609 331 PMC4306938__F9 Schematic presentation for araguspongine C-induced autophagic death in breast cancer cells 1950 3082 2475 PMC4307112__F3 Differentially expressed genes in cell proliferation and differentiation pathway between grass carp before and after food habit transition from transcriptome analysis 3630 355 1950 4342 PMC4317086__F1 Figure can be read from the upper-left corner in an anti-clockwise direction 7001 84890 6005 PMC4320971__F2 Sphingolipid metabolites in inflammatory disease 8877 80772 64781 56848 PMC4324900__F4 Identification of Genetic Determinants of the Sexual Dimorphism in CNS Autoimmunity 126669 387357 54806 6850 5796 PMC4325706__F3 Pathway Express analysis of the host response to IBDV infection in the spleen 7939 8772 7124 572 8717 842 6955 472 836 2056 8027 PMC4325706__F4 Pathway Express analysis of the host response to IBDV infection in the bursa 613 66037 1610 8915 930 PMC4326575__F1 Structure and signaling from the cilium and relationship with the autophagic pathway 5156 6608 90410 2475 8408 10533 9474 PMC4326637__F1 Biology of Advanced Uveal Melanoma and Next Steps for Clinical Therapeutics 5728 7204 6010 2475 PMC4331812__F5 Metabolic flux map of central carbon metabolism in cotyledons at early seed fill 7086 4397 10020 4118 5053 PMC4333206__F1 Notch receptors (Notch1-4) and ligands (DLL1, 3 and 4, Jagged 1-2) are expressed in tumor, normal, and endothelial cells 100187761 1017 1499 54567 PMC4335171__F1 Death and dessert: Nutrient signalling pathways and ageing 3481 3667 9798 5728 3480 PMC4336822__F1 Progesterone action in breast, uterine, and ovarian cancers 3045 100187828 1017 PMC4338749__F1 Drugs that inhibit folding or disposal of misfolded proteins 10013 4827 3916 22926 PMC4339403__F3 Unfolded Protein Response in Retinal Vascular Diseases: Implications and Therapeutic Potential Beyond Protein Folding 22926 7494 1410 PMC4344206__F1 Platelet signaling pathways 6850 2638 4512 6786 84876 PMC4344844__F2 Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development 5728 2885 2549 1499 2475 PMC4346946__F1 Nuclear entry of Cofilin-1 (CFL-1) via various stresses 3984 3985 54617 PMC4349374__F1 Molecular events in the autophagy pathway 9776 9140 9474 10533 83734 64422 PMC4350884__F8 EtOH and INK128 impact on the mTOR pathway and cellular response 2475 253260 1977 PMC4354380__F1 Polycomb and trithorax proteins regulate chromatin structure and gene expression 9055 404281 23411 PMC4355395__F4 The 12/15Lipoxygenase as an emerging therapeutic target for Alzheimer's disease 351 1020 6667 PMC4363166__F4 An extended signaling pathway that regulates basal P-glycoprotein activity at the blood-brain barrier 1901 5163 2475 PMC4382242__F2 Autophagy in cellular metabolism and cancer 8408 9776 9474 PMC4383556__F9 Transcriptome Analysis and Its Application in Identifying Genes Associated with Fruiting Body Development in Basidiomycete Hypsizygus marmoreus 4286 1499 7306 1638 2475 1311 253260 3091 1975 35 7249 PMC4384737__F2 Nucleotide sugar UDP-GlcNAc resides at the nexus of protein and lipid glycosylation 7175 8473 5238 10724 PMC4385866__F2 Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach 2147 2444 3382 22808 55922 84273 388324 100187761 619538 PMC4391824__F3 Expression of the known genes involved in polo signaling in PAH HPASMC 5426 9748 324 9055 8317 9126 PMC4395390__F3 Exploring Triacylglycerol Biosynthetic Pathway in Developing Seeds of Chia (Salvia hispanica L.): A Transcriptomic Approach 2194 178 355 2234 10160 2233 2091 2242 2521 PMC4404867__F1 Coagulation, anticoagulation and fibrinolysis maintain a delicate physiological balance between bleeding and thrombosis 7018 7035 5340 7448 PMC4408550__F1 Activation of TGFB requires liberation of the TGFB dimer from an inactive latent complex with the LAP 5045 5340 7939 387 PMC4413906__F2 Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus 6714 5241 7018 PMC4417967__F2 Relative adenine and thymine (%AT) DNA content of ergot alkaloid synthesis (EAS) loci 5617 8177 174 100653366 8318 100306940 2160 PMC4420620__F1 Novel functions of viral anti-apoptotic factors 7405 10533 64422 PMC4423712__F1 Cardiolipin synthesis and remodeling pathway 1040 9489 283871 5091 PMC4424001__F2 Hierarchical Feedback Modules and Reaction Hubs in Cell Signaling Networks 5331 1956 126669 PMC4426444__F2 Reconstructed metabolic pathways in the common ancestor of apicomplexans and dinoflagellates at the time of plastid gain (A) and in Hematodinium sp 1611 727 3652 2242 355 PMC4438467__F1 Mitochondrial cholesterol trafficking in regulation of macrophage sterol metabolism 335 3949 22937 1593 19 PMC4440880__F1 Activation and targeting of prosurvival pathways mediating FLT3 resistance 7852 2322 6387 5292 2475 PMC4442291__F2 Schematic summarization for the signaling mechanisms of the antifibrotic effects of H2S 7099 4087 4088 4615 4089 50507 23411 PMC4442886__F1 MTOR pathway and its interactions with other important pathways and cellular process relevant to cancer 1956 5728 7248 7249 2475 1017 7852 7428 PMC4447079__F2 Illustration of protein modification by the ubiquitin proteasome system 4597 4738 7341 PMC4447104__F1 Bacteria, the ER and the Unfolded Protein Response: Friends or Foes? 22926 83939 7494 468 PMC4448615__F1 Plant and yeast cell walls (CWs) 5163 7249 7248 PMC4450261__F1 Activation of the Keap1-Nrf2-ARE pathway by oxidants/electrophiles 9817 8452 4094 PMC4452069__F1 PI3K/Akt/mTOR signaling cascade 5728 5163 2475 PMC4454159__F1 Glutamine metabolic rewiring 23530 7808 29 11113 4118 27165 PMC4454460__F5 A model showing different pathways to repair replication fork damage due to structure-forming sequences 5893 118027463 5888 PMC4455348__F1 Schematic of HER3 engagedment in heterodimerization and signaling 2885 3297 2932 2475 572 PMC4456045__F1 All TLRs signal through the common MyD88-dependent pathway 2475 4118 4615 PMC4456452__F17 Pathway model for fly-wasp mediated social learning 81693 2332 474168 PMC4458429__F2 Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases 6714 5829 1399 4739 6850 2475 PMC4458453__F1 Pathway of eukaryotic translation initiation 1997 10209 1999 PMC4463992__F2 Primary regulatory networks 6282 6667 1059 6273 6010 7428 PMC4463992__F3 Most possible acting pathway of p42.3 protein by optimization of Bayes theorem 6282 1059 6273 6010 7428 PMC4469326__F4 JAK-STAT signalling pathway 867 2056 8027 5292 3569 PMC4475536__F3 Mechanism of action of paclitaxel 7099 4615 4827 572 PMC4475795__F1 UPR signaling schematic 83939 468 22926 6667 6668 PMC4482087__F6 Rewired transcription network regulating metabolic pathways for tolerant industrial yeast Saccharomyces cerevisiae NRRL Y-50049 9542 51083 220323 PMC4491987__F6 Effect of the combination of rapamycin and resveratrol on the PI3K/Akt/mTORC1 signaling pathway 3667 5163 7249 7248 6009 27250 1975 PMC4500525__F1 Mammalian inositol phosphate metabolism 5728 3705 3550 PMC4506163__F4 Gene product association networks extracted from the most significant (A) cellular and regulatory process pathways and (B) metabolic pathways involved in arteriotomy-induced carotid stenosis (listed in Table ) 443 1312 3030 2023 55837 PMC4509205__F4 PI3K/AKT network in renal cancer samples 4763 4351 572 637 3725 2353 4609 581 4149 84890 PMC4514860__F2 Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway 25805 50964 6500 PMC4519949__F2 Proposed effects of salubrinal on the xenotoxicant-activated ER stress signaling pathways 7186 83939 468 PMC4521753__F3 Identification of Oxygen-Responsive Transcripts in the Silage Inoculant Lactobacillus buchneri CD034 by RNA Sequencing 5226 6120 5236 5239 5238 5162 64853 PMC4526153__F4 The Biophysics and Cell Biology of Lipid Droplets 8694 84649 5091 4018 4099 PMC4532404__F7 Signaling pathway of focal adhesion 387 7408 3611 5728 2534 1398 126669 572 PMC4532781__F1 PolyQ-HTT impairs autophagy 6093 2475 23192 3064 9001 PMC4534763__F4 Identifying miRNA/mRNA negative regulation pairs in colorectal cancer 867 367 685 3725 1839 126669 2885 9542 2475 572 10718 145957 PMC4535966__F2 Ingenuity pathway analysis reveals an up-regulation of the NOTCH pathway in LGR5 high SW480 spheres compared to LGR5 low SW480 adherent cells 3714 8650 4099 3280 PMC4538308__F1 The mechanism by which DHA may interfere with the molecular signalling by activating glycolytic phenotype 5728 5465 7428 PMC4539069__F1 Proposed model for the complex cross talk between various receptors and mediators in early phase response in allergic rhinitis 4803 729230 1232 7442 PMC4542378__F10 Activated signaling pathways that regulate KSHV lytic replication during primary infection 1969 6714 2185 1385 PMC4543340__F1 HGF/MET signaling pathway 3082 2549 9846 PMC4546216__F5 Scheme of the phenylpropanoid pathway 790 1312 1230 2271 PMC4546755__F3 Overview of carcinogenesis and NRF2 responses 100500918 407018 8452 9817 406911 407024 PMC4556964__F4 Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway 5091 4050 4018 PMC4560339__F1 Multimodality targeting of MM in the context of the BM microenvironment 7422 3082 4609 23476 57823 952 5132 6387 3479 PMC4564397__F4 Salicylic acid and anthocyanidins use different strategies to inhibit tumor cell protective catalase 1362 847 27035 4841 3009 PMC4565031__F2 Case study 1 (synthetic signaling pathway): Hypergraph showing every possible logic gate consistent with the prior knowledge network 1950 1956 5894 7186 6885 4214 PMC4573218__F3 Some of the proposed signaling pathways activated by NK-R 6714 6010 126669 PMC4573851__F2 The roles of FANCM family proteins in replication fork repair and crossover control 23137 57697 641 80010 PMC4578605__F3 Depletion of Pkh affects glycogen metabolism 55276 5236 5238 PMC4579870__F1 Molecular events in autophagy pathway 9776 7405 9140 64422 10533 83734 9474 PMC4585452__F4 Schematic model of WNT signaling by the FZD receptor(s) 324 6010 1499 51701 PMC4585666__F1 Combination of transcriptomic and metabolomic analyses reveals a JAZ repressor in the jasmonate signaling pathway of Salvia miltiorrhiza 100379198 4609 4602 790 275 4350 PMC4589489__F3 Schematic of the ERBB(EGFR)/KRAS/BRAF/MAPK signaling axis, and its connection with the PI3 Kinase pathway 1956 5728 5170 2475 PMC4594309__F1 Neurogenic niches and Eph:ephrin signaling 1356 6346 2043 PMC4594353__F1 Characteristics, regulators and effects of the epithelial-mesenchymal transition (EMT) 1499 999 1000 PMC4595741__F1 Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica 4553 27159 4118 11113 3240 PMC4598984__F1 Data analysis of the identified Snf1 interactors 6886 6122 1358 PMC4600531__F1 Wnt Signaling in Bone and Muscle 324 387 5879 PMC4601190__F2 Epithelial cell recognition and discrimination of Candida albicans yeast and hyphae 5163 2475 7018 PMC4613459__F2 Repurposing metformin: an old drug with new tricks in its binding pockets 6774 3479 3480 595 7248 6009 PMC4613668__F2 MAPK/JNK signalling: a potential autophagy regulation pathway 5879 55626 9474 10533 664 9706 23192 9140 PMC4614139__F1 Mutations in PI3K, PTEN and AKT have dual effects on neuronal development leading to the formation of HMEG and FCD 5728 5163 7249 6009 7248 PMC4619170__F7 Even-skipped+ interneurons are core components of a sensorimotor circuit that maintains left-right symmetric muscle contraction amplitude 6102 545 4827 PMC4629436__F3 Regulation of HIF-1A pathway at different levels 2475 7428 4193 PMC4630557__F2 Signaling pathways of main checkpoints molecules 942 324 7535 2475 PMC4637890__F6 IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway 6774 2475 22863 9776 PMC4638384__F2 Regulation of the Hippo pathway in Drosophila 7791 4478 23558 23513 1739 PMC4644174__F8 Proposed signaling pathway for TOB-1-mediated progesterone signaling.Notes: TOB-1 was involved in the growth arrest pathway in response to progesterone in MCF-7 cells 10140 5728 6647 6648 PMC4649510__F7 Model of tissue homeostasis maintenance after an ER stress 7494 468 5879 4478 PMC4653709__F12 Proposed schematic representation showing the mechanism of ETH and its effect on neurogenesis 324 2931 1499 PMC4654121__F6 Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells 7249 7248 6001 6009 2475 1977 PMC4654485__F2 Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer 3091 7428 26523 55662 7422 4547 PMC4655822__F3 Establishment and Dysfunction of the Blood-Brain Barrier 4035 5159 1000 1003 84879 PMC4655987__F1 Aerobic very long chain-PUFA biosynthetic pathways modified from Napier () including microorganisms, plants, and animals 283985 1896 2717 PMC4657734__F1 TGF-Beta-activated non-Smad pathways in epithelial-mesenchymal transition 998 9618 5879 4087 4088 57154 387 4089 1386 PMC4659505__F12 Complexity of the direct and indirect effects of mTOR on signaling pathways 64223 64798 2475 253260 5163 7249 7248 PMC4659514__F1 Proteins implicated in Parkinson’s disease (PD) maintain a healthy pool of mitochondria 65018 10131 120892 PMC4662426__F5 Difference in expression of the calcium signaling pathway between rat neurons and OPCs grown in vitro 90550 5350 3932 857 858 859 613 952 PMC4667402__F2 Comprehensive illustration of transcription changes in skeletal muscle of red cusk-eel under handling stress using modified KEGG pathway maps using Pathvisio v3 7316 1674 7431 7168 7169 1756 7170 7111 8924 7171 10763 10277 5555 7347 7139 7138 6184 9706 6185 7405 4087 9140 4654 PMC4667861__F1 Signalling pathways and mechanisms regulated by vagal activation 6648 6774 7019 PMC4671959__F7 Mechanism of the Redox-Dependent Brf2 Blockade during Oxidative Stress and Carcinogenesis, Related to , , , , , , and During normal growth conditions (A) Brf2- and Nrf2-dependent transcripts are synthesized at basal levels 55290 6908 4553 56954 PMC4682803__F1 MTORC1 signaling to the translational machinery 64798 64223 27250 1975 23367 PMC4697050__F3 Signaling pathway of BDNF 2885 2549 572 PMC4701085__F10 Molecular pathways affected by Gcm 6608 5962 9843 8650 PMC4704494__F3 Chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells 3845 5728 207 208 1499 PMC4710172__F2 Calcineurin-NFAT pathway: Activation and regulation 23523 8445 4193 4513 2626 1386 PMC4714141__F1 Pathway of microRNA-7 in gastric cancer 2638 3480 1956 2475 999 PMC4722119__F1 Regulation of fatty acid synthase by O-GlcNAcylation, Terra incognita 7175 8473 355 PMC4728993__F1 Metabolic pathway of phenylalanine (Phe) 2806 2805 1644 5053 PMC4729111__F2 Metabolic pathway of l-Phe 2806 2805 1644 5053 PMC4730629__F7 Reactive oxygen species (ROS) pathway in bamboo 7018 2077 4602 847 780904 PMC4732855__F5 MAPK signaling pathway, determined using the Kyoto Encyclopedia of Genes and Genomes database 1610 2316 759 355 1616 4149 929 51295 11201 7975 3552 1956 8399 283120 9064 101927017 84647 1852 2263 100874433 PMC4733614__F3 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies 11201 6774 2638 613 947 2271 PMC4739231__F1 Signaling pathways demonstrating the link between Gq-coupled receptors and induction of autoimmunity 5894 5728 7249 6774 2475 PMC4741068__F2 Reconstruction of the insulin/insulin-like growth factor 1 (IGF1)-like signalling (IIS) pathway of Haemonchus contortus 9798 5163 208 PMC4751644__F1 PI3K signaling and common mutations related with ASD and schizophrenia 4763 4204 627 5728 5163 2332 2066 6009 64798 1977 PMC4758903__F1 MicroRNA-based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer 10252 2885 5921 161742 4763 5728 27250 PMC4759477__F3 Platycodin D‐induced G2/M phase cell cycle arrest in cancer cells 7465 4193 983 891 PMC4762492__F1 PI3K/AKT/mTOR signaling pathway and examples of drugs targeting each of its components.Note: RSK, 90 kDa ribosomal protein S6 kinase 1956 8821 5728 5163 572 6009 6194 PMC4772101__F2 Mechanical signaling and tissue growth 999 1499 6722 PMC4778564__F3 Hepatitis C Virus and Autophagy 9474 9140 345611 PMC4779832__F3 Cross talk between ROS and MAPKs signaling pathway 2885 6772 1386 4208 4205 4209 PMC478571__F3 Chart of cell cycle genes 6502 5111 993 902 595 9134 898 890 1022 1019 1017 990 8318 4171 25 10006 4999 4172 5925 4173 23595 4174 5000 4175 5001 23594 8317 57804 PMC4791278__F3 Ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells 472 4194 672 1164 PMC4791795__F2 Select Biological Pathways Significantly Associated with Differentially Regulated Genes 4117 1616 51701 1950 4049 4803 PMC4801794__F2 PI3K/AKT/mTOR signaling pathways 5728 5163 3611 2475 253260 6009 7248 7249 3667 PMC4813390__F3 Influence of TGFB‐SMAD and TGFB‐TAK1 signalling on adrenoceptor‐mediated pathways in LV heart failure progression 367 7048 7046 PMC4818529__F1 The comparison of different biosynthetic pathways for propane production 355 3045 100187828 84890 PMC4819199__F7 Intestinal Insulin Signaling Encodes Two Different Molecular Mechanisms for the Shortened Longevity Induced by Graphene Oxide in Caenorhabditis elegans 208 207 6649 PMC4820338__F1 Schematic model of RIP1-mediated regulation of the PI3K-Akt pathway 5728 3667 7249 7248 6009 2475 PMC4821196__F2 Summary of the intracellular signaling cascades that occur within neurons and glia within the brain 84890 2475 2932 3725 581 6750 847 5212 627 PMC4821380__F1 EGFR and IGF1R signaling pathways.Notes: Binding of extracellular ligands results in autophosphorylation of key tyrosine residues in the C-terminal domain of EGFR, which allows downstream proteins to bind through their Src homology 2 (SH2) domains 1956 3667 2885 5728 2475 7249 7248 3480 PMC4822806__F3 Molecular mechanisms involved in autophagy and NAFLD.Notes: 1 7249 7248 5728 2475 4703 PMC4825590__F1 Crosstalk between cell cycle regulators and cellular metabolism 595 1021 1019 324 5209 PMC4826959__F1 Schematic representation of polycomb-repressive complex 2 inhibition mechanisms 2146 6418 10873 PMC4838196__F3 Phosphoproteome analysis links protein phosphorylation to cellular remodeling and metabolic adaptation during Magnaporthe oryzae appressorium development 51573 84174 10487 84249 83734 64422 9474 10533 9140 9776 83445 8723 55276 PMC4840027__F2 Quantitative regulation by the TCF/Beta-catenin asymmetry pathway 10940 90196 7018 5447 PMC484174__F8 A testable model for the modulating role of Dcs1 in the yeast stress response 167227 4256 1977 PMC4843516__F2 Neuroendocrine pathways regulate stress tolerance in C 5163 207 6446 208 9437 9436 PMC4855676__F2 NFAT signaling pathway 359948 2353 3725 PMC4859755__F1 Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer 6690 1080 5644 5728 5340 PMC4861870__F3 Cellular innate response to rotavirus infection 7098 57506 6772 6773 3661 3665 PMC4867331__F3 Notch and Wnt pathway inhibition by natural products 4609 100188776 960 9794 324 PMC4871122__F1 Copper transport and regulation in Schizosaccharomyces pombe 10063 6341 6647 PMC4872954__F1 Obesity versus osteoarthritis: beyond the mechanical overload 3952 3716 3717 6774 4615 8717 7186 7189 10454 PMC4891110__F8 Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate 6886 2203 2026 5105 2023 PMC4891345__F1 Genes and biological processes shared in Parkinson’s disease (PD) and cancer 5728 65018 120892 6622 4513 2475 PMC4894443__F4 Flatworms have lost the right open reading frame kinase 3 gene during evolution 8780 84946 55781 28987 PMC4898271__F6 The ras signaling pathway 1950 2045 1956 PMC4900217__F2 Induction of oxidative stress and defense pathways 4843 5634 50507 3258 2936 7498 2937 391051 646625 PMC4901281__F7 In-depth comparative transcriptome analysis of intestines of red swamp crayfish, Procambarus clarkii, infected with WSSV 867 2056 3586 8027 5292 3569 4609 PMC4903900__F1 Epigenetic modulation of gene expression governs the brain’s response to injury 9055 404281 23411 PMC4904898__F2 PI3K/AKT pathway 253260 5163 2475 5728 7249 7248 6009 PMC4905241__F1 Cell cycle-dependent regulation of E2F1 3276 472 10419 1869 4609 729 6502 PMC4905575__F3 PP2A positively and negatively regulates the Wnt signaling pathway 2932 324 1499 PMC4911704__F1 MTOR in maintenance of glomerular epithelial cells 6446 7249 51256 7248 8408 9776 PMC4916380__F3 Central metabolic pathway in C. tyrobutyricum 5805 3250 3045 100187828 10466 PMC4918286__F1 Hippo pathway signaling in Drosophila and mammals.Note: (A) Signaling diagram 351 79981 4771 4485 166824 84962 26524 860 5077 6910 474168 332 374 PMC4919564__F1 Regulation of AMPK by metabolic stress, LKB1, and intracellular Ca++ 7249 3156 2475 4899 PMC4921268__F2 Searching for the Chokehold of NRAS Mutant Melanoma 2475 595 1021 1019 995 983 PMC4923130__F1 Glucocorticoid-mediated modulation of pro-inflammatory pathways 2638 7099 7097 4615 3603 PMC4926156__F2 VacA interferes with T-cell activation and proliferation by manipulating the T-cell receptor pathway and the cell cycle 940 3932 27040 2353 3725 PMC4931134__F1 Disruption of miRNA biogenesis by estrogens and cigarette smoke can lead to oncogenesis 4609 29102 1956 PMC4947819__F2 SOX2-mediated sensing of cytoplasmic DNA and the associated signaling pathway in neutrophils 3553 1386 2002 23118 6657 PMC4950926__F6 Schematic presentation of mechanisms of actions of CTS 3479 4654 4656 7168 PMC4951239__F2 Functional role of autophagy in gastric cancer 728655 23411 2475 9776 PMC4956935__F2 Proposed IGF‐interaction with PPAR‐G signalling in CVD epigenetics 7249 7248 6009 2475 PMC4966488__F1 Viral oncolysis dependent on RNA-activated protein kinase (PKR) inactivation 83939 6774 8772 PMC4967105__F3 SKN-1 in the development of C 4397 1499 10940 5469 PMC4967202__F2 MMP-9 signaling in the left ventricle following myocardial infarction 3603 729230 6667 948 3553 5340 PMC4975561__F1 Roles of the PtdIns(3,4,5)P3/Akt pathway on insulin signaling in liver fat and muscle tissue with representative substrates indicated 5728 7249 3638 PMC4978167__F1 Integration of Endothelial Protease-activated Receptor-1 Inflammatory Signaling by Ubiquitin 7054 387 6010 PMC4979485__F1 LINP1 regulation and role in the NHEJ DNA-repair pathway 1956 472 108570035 3014 3981 PMC4980327__F1 Molecular alterations cause metabolic switching in cancer cells and severe metabolic changes in the tumor microenvironment 207 2475 3091 57103 5728 9997 2744 4609 PMC4985055__F2 BMP signaling in bone 26585 10454 4090 4086 4092 4091 57154 4089 860 PMC4987729__F2 Processing of engulfed dying cells requires LC3-associated phagocytosis (LAP) and promotes an anti-inflammatory response 5879 7405 11337 9140 9474 10533 64422 19 PMC4987730__F7 Antibody-mediated blockade of the PS signaling pathway in the tumor microenvironment 7301 8205 11314 PMC4991322__F1 The conserved pathway of sterol synthesis, storage and transformation in C 3422 1733 2023 1386 PMC4995965__F4 DVL phosphorylation by NEK2 affects Wnt signaling 3630 100187761 4751 PMC4996735__F1 Redox signaling: an evolution from free radicals to aging 9817 1728 6714 PMC4998060__F2 Signaling network that regulates ISC activity in response to injury 4478 474168 1956 PMC5003605__F1 Metabolic pathways and genes involved in the utilization of nonfermentable carbons 2147 2203 54994 5105 4191 PMC5003917__F2 Aberrations in the cyclic AMP-dependent signaling pathway in adrenocortical tumors 50940 5573 2271 79798 4221 4158 1499 PMC5006437__F1 Regulation of molecules in the NMDAR signaling pathway on learning and memory 627 23237 4133 PMC5006950__F1 PD and PK pathways of HMGCo A reductase inhibitors (Statins) 3156 55937 1071 PMC5008074__F3 MicroRNA (miRNA) biogenesis pathway and its regulation by Smad proteins 7018 29102 54487 5901 PMC5019079__F3 Hypothetical scheme of production and effects of oxidized fatty acids 5053 26136 4015 6256 PMC5031209__F2 Apical signals inhibit nuclear YAP localisation 6714 6010 1956 PMC5032153__F1 Notch signalling pathway 54567 6868 11319 PMC5035594__F1 Anticipatory UPR Activation: A Protective Pathway and Target in Cancer 1938 83939 29904 22926 PMC5035969__F1 Schematic presentation of the N-linked core oligosaccharide structure 9695 55741 80267 PMC5036923__F1 The IMD pathway and its regulation by Die and WntD 8322 23118 8772 PMC5039640__F6 Unravelling molecular mechanisms from floral initiation to lipid biosynthesis in a promising biofuel tree species, Pongamia pinnata using transcriptome analysis 95 65057 4018 PMC5054337__F3 Simplified central carbon and amino acid metabolic network 1636 11113 4118 PMC5055439__F1 Stem cell metabolism 5371 3091 2475 PMC506920__F6 Changes in transcripts associated with the DNA synthesis pathway 990 4999 8317 8318 1017 PMC5072731__F8 Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations 4149 2021 472 4615 581 836 PMC5094313__F5 Metabolic pathways that may be affected by lactate flooding of brain after traumatic brain injury 266790 5091 11113 PMC5097071__F6 Redox homeostasis and metabolic changes during the adaptation to proteasome inhibitors 3939 2805 47 80221 197322 PMC5098112__F6 Manually curated version of RISN 324 8213 51027 572 PMC5099148__F1 Biosynthetic pathway of pharmaceutical terpenoids 65985 4598 3416 1379 PMC5101720__F8 Pathway analysis using the KEGG Pathway database 5972 6102 6185 23237 6184 PMC5113843__F3 Proposed metabolic role of RubisCO, with genes identified in the PER-1 (blue line) and WS6-1 genomes (purple line) 2539 25796 2821 6120 7086 22934 2597 PMC5115958__F1 Non-invasive metabolic imaging of brain tumors in the era of precision medicine 5163 4609 57103 PMC5122382__F9 Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule 1019 2475 100187761 PMC5123387__F24 (Abstract P2) 7039 6010 7008 PMC5145083__F9 Neuropathy optic glaucomatosa induced by systemic hypertension through activation endothelin-1 signaling pathway in central retinal artery in rats 59272 1636 4142 PMC5146659__F5 Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta 5310 5311 6009 355 2475 595 PMC515251__F1 A minimal metabolism 5805 4553 95 PMC5154738__F2 Translational Control of Long-Lasting Synaptic Plasticity and Memory 3667 5163 5728 7248 7249 6009 2475 253260 PMC5171696__F1 Anaplastic lymphoma kinase (ALK) signaling: Pathway figure that depicts normal activation of ALK through ligand binding 5764 238 3725 2475 PMC5187897__F1 Intrinsic and extrinsic apoptosis pathways in mammalian cells 317 8717 8772 355 PMC5190058__F8 Combination of gemcitabine-containing magnetoliposome and oxaliplatin-containing magnetoliposome in breast cancer treatment: A possible mechanism with potential for clinical application 4280 2765 581 PMC5192315__F2 Toll-like receptor signaling pathways 54472 3654 7189 51295 7083 5970 3603 7099 4615 114609 7097 PMC5198544__F3 Tissue injected with B. asper venom 7099 3552 3553 PMC5203625__F3 Selected metabolic pathways of the putative novel SAOB unFirm02_FrBGR cluster 2 717 95 2242 PMC5219787__F5 PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways 5728 5163 7249 7248 PMC5223024__F1 TLR and the related TNFR and IL-1R signaling pathways 7124 929 8717 7186 114609 4615 7189 7187 23118 5970 3661 3569 3553 PMC5226613__F3 Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases 1956 7097 10333 7099 7189 4615 2475 PMC5240216__F3 IRE1ɑ-XBP1 is one of the arms of UPR that polarizes tumor-infiltrating myeloid cells into highly immunosuppressive populations 6774 6778 7494 PMC524028__F2 Regulation of the mTOR signaling pathway 5163 7248 7249 6009 1977 6194 PMC5244562__F1 Scheme of PI3K pathway with candidate regulators of mTORC2 colored in green 3667 5163 2475 253260 64223 PMC524522__F9 Mapping molecular correlates of aggressive mesothelioma to highly curated molecular pathways can identify the underlying molecular mechanisms of the disease 7832 100187761 100 6256 7465 PMC5250669__F7 UPR activation in the spinal cord from an X-ALD mouse model 215 7494 22926 83939 468 9709 55741 PMC5265918__F9 Atorvastatin inhibits insulin synthesis by inhibiting the Ras complex (Ras/Raf/extracellular signal-regulated kinase/CREB) in INS-1 cells 2885 5163 5164 PMC5282886__F3 IGF signaling regulation in EMT 2885 6469 1499 9839 6935 PMC5286373__F2 Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype 5163 2539 26227 3939 PMC5287062__F1 Cellular senescence 5728 4763 1029 472 4193 PMC5290160__F7 MYC-mediated mRNA cap methylation of Wnt/Beta-catenin signaling pathway transcripts 1022 8731 8295 4149 4609 11201 2932 PMC5297752__F1 Unfolded protein response (UPR) pathways in mammalian cells 22926 7186 468 PMC5297831__F2 The mTOR signaling pathway 5163 5728 7248 7249 6009 64798 6194 PMC5297839__F1 Phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR), retrovirus-associated DNA sequences/mitogen activated protein kinase (RAS/MAPK) pathways and c-MYC are master regulators of cell growth and proliferation 5728 11201 1977 6194 PMC5309409__F1 Nucleotide excision repair (NER) pathway 7508 7507 2067 PMC5331050__F5 NOD-like receptor signaling pathway 10392 10454 64127 23118 257397 3553 PMC5335622__F2 Theoretical concept of combined application of checkpoint blockade therapy and DGK-inhibition 940 3932 7535 3458 PMC5336175__F10 Differential phosphorylation of YBX1 on Ser-176 and Ser-165 and their role in NFKB activation 4904 1506 3553 PMC5341237__F1 Diagram showing key components of the IL‐6 signal transduction pathway that could account for lipogenic gene expression in hepatocytes 9021 6774 355 PMC5341618__F1 Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms 51024 1759 65018 79594 55669 9927 7416 29110 10133 4077 139341 440738 84557 664 55626 9706 23786 10533 83734 9140 9474 84749 10128 PMC5343325__F5 Jak-STAT signaling pathway 867 2056 8027 5292 3569 PMC5343774__F2 Summary of cross-talk between cancer cells and the tumour microenvironment mediated through the 5-lipoxygenase pathway 10800 57105 4048 4056 PMC5347023__F6 High-Concentrate Diet Induced Milk Fat Decline via Glucagon-Mediated Activation of AMP-Activated Protein Kinase in Dairy Cows 7038 355 5465 PMC5347564__F1 Hippo signaling pathway is the only pathway enriched with up-regulated DEGs 351 474168 1956 11113 PMC5349319__F3 Summary of identified microRNAs that target key proteins of autophagic pathway for regulation of autophagy 693215 7405 8408 9706 60673 55626 10533 9140 83734 9474 8878 64422 PMC5352101__F3 Type I insulin-like growth factor receptor signaling in hematological malignancies 2885 5728 3667 8660 5163 572 7249 7248 2308 2932 PMC5352242__F1 Schematic illustration of the intracellular trafficking dynamics of mitochondria-targeting nanoparticles 65018 51024 64786 PMC5354660__F5 Cycling hypoxia affects cell invasion and proliferation through regulation of claudins 6839 1719 1021 1019 PMC5358377__F6 Cellular localization of the autophagy genes regulated by 1,25(OH)2D3 (Ingenuity Pathway Analysis software) in MCF-7 cells 2475 9776 596 83734 55014 718 64422 23001 10533 PMC5358695__F5 Layered network between adalimumab and MG 3458 3586 581 2213 3845 717 2212 2215 355 940 3265 3122 2214 7124 942 3125 673 3107 3002 716 3569 693122 PMC5360635__F1 Autophagy mechanism 23192 64422 10533 9140 55054 9474 PMC5361499__F1 Amyloid precursor protein (APP) processing.APP preferred processing is the non-amyloidogenic pathway which digests with Alpha-secretase followed Gamma-secretase and takes place at the plasma membrane (PM) 1191 4035 54209 274 6653 8301 PMC5362350__F1 Role of Autophagy in HIV Pathogenesis and Drug Abuse 2475 8408 9776 83734 10533 9140 22863 9474 PMC5366816__F2 Drug targets in AR signaling pathway 1586 1956 367 2475 PMC5374984__F1 The autophagy pathway 2475 9776 8408 55626 10533 PMC5381176__F8 MiR-93 activates the PI3K/Akt pathway by targeting LKB1/PTEN/p21 1956 5728 5163 7249 7248 2475 PMC5384343__F2 MTOR signaling pathway 1956 5728 7249 7248 5163 64798 6009 3667 6194 1977 PMC5384647__F10 An ID2-dependent mechanism for VHL inactivation in cancer 3398 8453 7428 PMC5386389__F8 ATG5-ATG12 involvement in FMDV-induced type IIFN signal pathway 9140 9474 7187 29110 3661 PMC538777__F7 Novel Jun-Dmp1 pathway 1019 595 4609 1758 4193 PMC5390489__F5 Metabolic switch between MEP and MEC 2597 5132 5183 1611 PMC5394422__F2 The autophagy pathway and core autophagy proteins 10533 9140 9474 55626 83734 22863 7405 64422 3920 26100 55062 8408 9706 55014 PMC5398990__F3 Schematic overview of underlying pathophysiology and targeted therapies in neurofibromatosis 1 (NF1)-associated malignant peripheral nerve sheath tumors (MPNSTs) 4763 2475 6790 7157 1029 PMC5399913__F1 Role of Srs2 in the promotion of PRR 5888 118027463 5111 56852 PMC5403850__F1 Pathological effects of chronic oxidative stress 948 7054 3667 PMC5405063__F1 Regulation of translation initiation by the (TOR) pathway, eIF4E activity and eIF2A phosphorylation in response to developmental and environmental cues in plants 914 1977 10985 83939 8667 PMC5406241__F1 Schematic illustrating our strategy to generate iPSCs resistant to IL-1-mediated signaling for tissue engineering applications 4615 8717 23118 10454 85451 PMC5411790__F1 Postulated interaction between enzastaurin and erlotinib in the EGFR pathway 2885 5728 2475 572 595 PMC5414155__F7 Overall impact of ethanol stress on C 2695 2752 46 7851 PMC5426069__F6 Analogue signalling pathway of TXNIP mediated by ER stress may be a novel therapeutic target in SAH-related EBI 83939 22809 10628 114548 PMC5427281__F8 Model depicting the mechanism of phagocyte priming by apoptotic cells 1398 5880 5879 PMC5428057__F6 Schematic overview summarizing the functional significance and regulation of COX-2 in PDAC 1950 1956 2885 6667 PMC5428929__F6 Genome-wide transcriptome profiling of radish (Raphanus sativus L.) in response to vernalization 1999 574414 80742 8205 PMC5429649__F11 The mechanism of Salvia fruticosa-induced relaxation of rat isolated aorta 4513 4512 717 PMC5431817__F4 Summary of the main effects of diabetes and NRG1 treatment in gastrocnemius muscle 7019 4899 2066 948 PMC5445378__F1 EGF-R and TGFB signaling pathways interfered by E5 1956 4087 4089 PMC5448108__F7 A proposed model for the regulation and function of two Grp78 genes in JH-stimulated locust vitellogenesis 6714 83939 4173 4176 PMC5451429__F8 Proposed model for the effects of GSK3B inhibitors on HCV virion particles’ assembly/release 2932 338 348 PMC5452017__F2 Brain metabolism in health, aging, and neurodegeneration 5209 2147 324 999 5166 PMC5454811__F4 Schematic diagrams of (A) the BR biosynthesis pathway, (B) BR signal transduction pathway, and (C) auxin signaling transduction pathway 1362 1431 51411 PMC5454963__F1 Proposed action mechanisms of glutamine in intestinal cells 2475 6772 6774 6775 PMC5456285__F6 HCoVs on ER stress response 22926 83939 468 7494 PMC5458216__F7 Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer 5728 6714 2475 1977 1398 PMC5460284__F4 Network model describing association of hyperactivated mTOR signaling with developmental and morphological defects in forebrains 4553 367 100187761 4597 7248 PMC5467317__F1 Cholesterol and isoprenoid synthesis pathway which shows the inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase by statins 387 5879 998 PMC5468232__F12 ARF/p53 pathway 472 545 4609 836 4193 64065 5728 7249 64326 PMC5472670__F1 The UPR signaling pathways 83939 468 7494 PMC5474932__F1 Integrated Transcriptomic and Metabolomic Analysis of Five Panax ginseng Cultivars Reveals the Dynamics of Ginsenoside Biosynthesis 4598 9961 253430 3652 4047 8213 369 PMC5477485__F1 Insulin-dependent signal transduction pathways 2885 2534 5728 2475 7249 7248 253260 637 572 1977 6009 6651 4193 PMC5478692__F1 Schematic overview of Imd pathway in Drosophila melanogaster 8772 23118 1540 6007 PMC5481839__F6 DOT1L safeguards cartilage homeostasis and protects against osteoarthritis 10891 23411 84444 51176 PMC5486049__F5 Scheme representing major factors of CWIP and the calcineurin signaling pathway 11043 998 6094 1255 PMC5487853__F2 Representation of cilia-associated molecules that have been implicated in DNA damage responses (DDR) 22897 8481 3014 9656 5108 983 1017 472 545 56623 80254 284086 891 PMC5490640__F4 Ubiquitin enzymes in the regulation of T cell-mediated autoimmunity 29851 940 326 7535 83737 5970 10273 7874 50943 1540 6502 PMC5490640__F7 TRIMs in the regulation of the immune response 7706 117854 1283 201292 81844 PMC5493925__F3 Regulation of the zebra finch RLR pathway 1540 338376 3661 10010 8772 7186 100187907 PMC5500564__F4 Differential gene expression in xenobiotics metabolism pathway between Asian American and Caucasian American 1733 2993 55577 10020 1854 PMC5501684__F6 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection 100187761 2247 7039 4092 4313 8009 PMC5508527__F3 Metabolic reprogramming and tolerance during sepsis-induced AKI 7124 7248 7249 6009 51548 23411 6769 PMC5509628__F2 Cav1.2 and Cav1.3 signaling mechanisms 771 83939 4204 PMC5509685__F1 Simplified sphingolipid metabolic pathway 56848 8877 8879 2744 PMC5512440__F7 Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis 19 3949 948 PMC5514737__F6 Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins 5923 6714 2885 387 1398 5879 1793 3984 5058 3985 PMC5516868__F1 Snf1 pathway and its components 27010 147912 51083 717 3297 3084 9542 PMC5518130__F4 Differently expressed protein-coding genes and lncRNAs participating in the AMPK signaling pathway via DAVID KEGG analysis 2147 29904 25886 1080 355 948 3479 7249 3630 3643 6009 2475 PMC5529928__F1 CXCL12/CXCR4 signaling and related pathways in HCC progression 6387 7852 4087 4088 PMC5530849__F4 KEGG pathway of apoptosis.Notes: The red-colored genes are differentially expressed genes enriched in the pathway in the study 7186 759 790 110366357 8717 355 10020 8739 4803 PMC5532627__F2 Linking processing of clustered DNA damage and immune response 325 472 2237 7518 6347 PMC5541362__F2 Serotonin and serotonin transporters in the adrenal medulla: a potential hub for modulation of the sympathetic stress response 4280 6418 7054 PMC5545101__F3 mTORC1 signaling and the metabolic control of cell growth 468 4609 4975 790 PMC5549800__F6 Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors 5163 7249 54541 7248 5091 1975 6009 1977 1999 6194 PMC5557856__F6 Proposed mechanism by which CoQ10H2 improves metabolic function and inhibits insulin resistance in KKAy mice 355 23411 5465 PMC5559046__F3 Cooperation of 20HE, IS, and TOR signaling pathways in the regulation of fly larva growth and development 3398 3397 4536 5728 5163 56961 7248 7249 6009 PMC5559228__F2 Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways 930 6850 4067 2885 5728 695 253260 2475 57600 96459 7249 7248 6009 8408 PMC5563293__F2 Schematic presentation of the fusion-activated Ca2+ entry (FACE) 84890 100 928 790 84876 PMC5564318__F3 Up and down-regulated metabolic proteins in PANC-1 cells 5232 2026 1431 2271 PMC5564844__F1 Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer 1956 2885 5163 PMC5573916__F1 Major mTOR signaling network 7124 1950 1956 3667 2549 5728 5163 7249 7248 6009 2932 PMC5574030__F1 An overview of central carbon metabolism 2821 2597 790 1431 PMC5580463__F4 PI3K/AKT and RAS/EGFR/ERK pathways 2064 2065 1956 2885 5163 5728 4193 572 7248 2475 PMC5581728__F2 Molecular actions of HDIs in sarcoma 2521 8772 581 5914 5728 4193 4312 PMC5597045__F1 RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic-acid-based metabolites such as lipids 2196 2195 120114 79633 PMC5597045__F2 RNAi-based biosynthetic pathway screens to identify in vivo functions of non-nucleic-acid-based metabolites such as lipids 6688 8877 427 2629 95 PMC5597136__F4 Known and recovered GRN for cell cycle pathway in yeast Saccharomyces cerevisiae 84188 1201 991 990 PMC5597488__F5 Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder 7054 1813 1812 1815 627 761 PMC5600869__F1 Schematic diagram for molecular mechanisms of activation of ER stress 22926 5266 83939 468 PMC5603666__F10 Graphic representation of pathways for furanodiene-induced cell apoptosis and for doxorubicin-resistant MCF-7 cells outcomes 759 581 572 PMC5607427__F6 Model of Syk and SFK signaling in B 8685 6850 5879 998 PMC5610669__F2 IGF-1R downstream signaling 3479 3480 3643 3667 5163 2885 5728 7249 7248 572 PMC5615778__F2 Working model for sensing of glucose availability by AMPK and its potential interactions with the mTORC1 signalling pathway at the lysosome 7248 7249 6009 PMC5617803__F1 The pikromycin (Pik) biosynthetic pathway 1356 95 1674 PMC5618562__F3 Interplay between melatonin, YAP/TAZ, and metabolic pathways 8471 3667 2475 6910 1499 PMC5620210__F2 ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway 1499 2932 324 2534 2475 6714 998 PMC5621106__F1 Double-strand break (DSB) repair pathway choice 1763 641 7486 9156 PMC5629314__F2 Pathway of de novo fatty acid synthesis in C 2195 2196 120114 2717 79633 PMC5642500__F7 HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma 5163 2885 2475 7428 1956 2065 PMC5647956__F1 Artemisinin biosynthetic pathway in A 4598 9961 4597 3652 PMC5658232__F1 PI3K/Akt/mTor pathway and effects of mTOR-inhibitors 5170 3667 7248 7249 6009 PMC5661624__F4 Redox regulation of cell mobility 4193 387 6714 5879 998 1499 2932 5728 PMC5661633__F2 NFKB in the regulation of NLRP3 inflammasome 3553 114548 4615 7189 23118 10454 PMC5666614__F3 Lipids at membrane contact sites: cell signaling and ion transport 84876 51669 6786 23344 PMC5670164__F2 Non-canonical activation of the sonic hedgehog (Shh) pathway 6469 6608 51684 2735 5728 PMC5674068__F10 The breast tumor vs mammary gland serial-omics experiment 2885 207 2475 253260 2194 31 6395 7038 5091 2167 PMC5678884__F9 Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus 998 1363 847 PMC5679229__F3 Nitric oxide - the forgotten child of tumor metabolism 2744 2194 5315 PMC5679454__F4 Tissue force programs cell fate and tumor aggression 999 3091 23513 6010 PMC5682898__F7 Proposed model for the neuroprotective effects of XJDH in OGD/R injury 7099 4615 7189 PMC5688152__F7 Schematic overview of metabolic pathways of P 9380 100187761 1431 2717 65057 18 1733 PMC5689203__F1 Schematic representation of secretory protein folding and quality control, the unfolded protein response pathway, and the heat shock response 3297 22926 10013 PMC5691648__F6 Predicted pathways deregulated during ZIKV infection 22937 22926 7186 83939 468 7494 821 811 596 10808 267 7415 8796 PMC5691655__F2 HBV components interact with DDR pathways and proteins 4968 79677 23137 1642 PMC5691663__F1 Thyroid hormone-induced interference with resveratrol-induced antiproliferation is blocked by tetrac and its nanoparticulate analog 7341 1499 8091 6241 PMC5693225__F6 RPL23 links oncogenic RAS signaling to p53-mediated tumor suppression 9349 4193 2475 PMC5693256__F2a DNA repair after oxidative stress: current challenges 4968 142 7515 PMC5693401__F3 Signaling pathway network model: Panel (a) presents the biological network describing the mTOR pathway (based on Fig 2475 1956 5728 1977 PMC5701508__F2 PI3K signaling pathway.Notes: (A) Activation of receptor tyrosine kinase (RTK) by a ligand results in phosphorylation of the receptor and adaptor proteins 5728 51083 4193 5163 2475 PMC5702246__F6 The PTHLH/PTH1R-ATF2 negative-feedback loop 5744 85451 1386 PMC5702962__F1 Structure of (A) HGF and (B) Met 3082 2549 6774 2885 998 5894 5879 2475 PMC5705877__F1 Biosynthesis of ceramide, sphingosine-1-phosphate, and ceramide-1-phosphate (a) 1674 6611 8877 56848 64781 PMC5709847__F2 Regulatory mechanism of expression of DNA damage response genes by the checkpoint pathway 6055 6054 4550 6053 PMC5723914__F1 FGFR signaling pathway 3535 10818 2885 2549 PMC5727283__F5 ER stress and the caspase proteolytic system are important regulators of muscle protein homeostasis 22926 83939 7494 468 9474 9140 PMC5727528__F3 Metabolic interventions predicted by the OptForce algorithm 2539 6120 3652 51132 PMC5734931__F2 Formation of autophagasomes in autophagy 10533 9140 64422 83734 9474 8408 9776 PMC5740024__F1 pH Dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs 95 2638 4255 4280 PMC5742211__F1 Simplified pathway of de novo sphingolipid synthesis 56848 8877 1674 PMC5742578__F1 Structure and function of ARNAX 3661 7098 148022 57506 PMC5742740__F1 Hippo signalling pathway in Drosophila and mammals 60485 4485 26524 9113 10413 PMC5744685__F8 Targeting Metabolism for Cancer Therapy 4548 4507 10419 PMC5747948__F5 Top canonical pathway is entitled, role of BRCA1 in DNA damage response 84126 545 472 9656 580 51594 11073 4436 4292 PMC5748001__F3 Flexible Roles for Proteoglycan Sulfation and Receptor Signaling 84894 1956 6010 2475 2932 6714 PMC5751143__F1 Induction of PD-L1 by IFNG signaling pathway and microRNAs target the key genes in the pathway 100616241 5728 406979 2475 1975 3659 PMC5756134__F2 An Unexpected Friend – ROS in Apoptosis-induced Compensatory Proliferation: implications for regeneration and cancer 9049 474168 331 PMC5759178__F6 Schematic model for EGFR-PI3K/AKT signaling activation induced by Notch1C1133Y mutation 3067 4851 100188776 1956 PMC5769420__F4 Aurora kinase A and aurora kinase B interact with oncogenes to initiate tumorigenesis 6790 672 5898 PMC5771830__F5 Cancer cell metabolic changes linked to hyper-O-GlcNAcylation 3091 4609 1950 3845 8473 10724 PMC5785435__F2 Bevacizumab-Induced Hypertension: Clinical Presentation and Molecular Understanding 572 842 4512 351 PMC5789323__F2 Simplified relationship between ROS-induced redox signaling and mitochondrial dynamics 9817 3091 1785 4976 PMC5789355__F1 Signal transduction through the mTOR complexes 5728 5163 2475 64798 6446 7249 7248 6009 6774 790 1977 1975 PMC5789368__F1 Key players in the mammalian autophagy pathway discussed in this review 7248 6009 9776 8408 7942 22863 PMC5793041__F6 Integrative view of DENV-induced metabolic alterations in hepatic cells 7038 2194 95 PMC5796233__F1 Tumor progression toward cancer metastasis 1499 7412 355 406952 5728 999 PMC5796233__F2 Overview of anticancer properties of pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene; PS) 100313824 1956 9112 355 4318 4582 1499 5728 PMC5797591__F1 Schematic overview of the roles of the Notch pathway in CD8+ T cells and its application to immunotherapy 3458 3280 1840 PMC5798385__F7 Proposed model for regulation of S6 phosphorylation (P) by the cAMP/PKA pathway 7249 7248 6009 64223 64798 PMC5802806__F5 Proposed mechanism 730 63826 140821 PMC5806469__F1 Putative lignin biosynthesis pathway with identification of species-specific reactions 790 1312 6476 PMC5809464__F9 Lipid metabolic pathway analysis of identified differential lipid species 847 55364 55253 100187761 5091 PMC5812824__F1 Gonadotropin regulation by pulsatile GnRH: signaling and gene expression 3972 2798 8926 PMC5817860__F3 Crosstalk between c-Met and EGFR 2885 2475 572 7039 1950 1956 PMC5819907__F1 Calcium signaling pathway, with red font indicating target genes 90550 5350 858 859 613 952 PMC5821033__F2 TGFB/SMAD4 signaling in cancer 2475 4087 5728 4088 4092 4089 324 1499 7018 1386 PMC5821844__F7 Differentially expressed artemisinin and other terpenoid biosynthetic pathway genes of A 4598 9961 3652 3552 PMC5825873__F2 Pathways that regulate mTORC1 and mTORC2 signaling 1956 5728 2885 5163 6009 PMC5828951__F2 Targeting Bromodomain and Extraterminal Proteins in Breast Cancer 5728 2475 23476 PMC5833693__F6 Glucocorticoid-induced apoptotic signaling pathway 2638 596 572 2885 PMC5834263__F11 Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death 6774 2475 3297 PMC5834423__F1 MicroRNAs (miRNAs) targeting insulin signaling mediators 5163 3667 8660 2885 3845 2308 PMC5841365__F2 Macroautophagy: an overview of the molecular pathway and mutations associated with congenital disorders of autophagy 9140 10533 83734 22863 11152 64422 8408 9474 9776 4864 3916 80208 57724 57231 PMC5842195__F2 Cell cycle arrest signaling 1017 1021 1019 983 PMC5842404__F3 B cell receptor (BCR) signalling pathway 6850 4067 29760 695 3684 1610 174 6672 8915 8853 640 PMC5844972__F2 Three pathways of the unfolded protein response (UPR) 22926 2744 7494 468 PMC5849286__F1 Sphingolipids and Redox Signaling in Renal Regulation and Chronic Kidney Diseases 95 1674 5091 6611 PMC5851872__F1 Molecular Regulation of Follicle-Stimulating Hormone Synthesis, Secretion and Action 2798 467 1958 7536 1499 PMC5860992__F1 Adapting Secretory Proteostasis and Function through the Unfolded Protein Response 22926 83939 7494 468 PMC5864191__F4 Functional association between mutp53 and mevalonate pathway-associated oncogenic proteins (Ras, RhoA, YAP/TAZ) 1956 208 387 PMC5866223__F3 Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension 339855 6010 875 PMC5867005__F1 UPR signalling pathway 83939 6667 6668 468 PMC5867024__F2 Diagram showing the biased activation of CGRP receptors and AM1/2 receptors by ADM2, as well as the downstream signal pathway 79924 10266 10268 10267 2548 PMC5869074__F1 Cross-talk between protein synthesis, energy metabolism and autophagy in cancer 5728 7249 7248 6009 8408 60673 9776 83939 9140 1977 29904 1938 468 3667 PMC5869528__F12 NOD-like receptor signaling pathway 6651 64127 7205 6347 9118 PMC5872601__F1 The signalling pathways of UPR 83939 468 7494 PMC5876464__F1 Signaling pathway of GRP78 1012 22926 468 PMC5876695__F3 Network model of oncogenic signal transduction in ER+ breast cancer 3169 5728 5163 8085 4609 6446 1021 1019 1017 2309 596 572 PMC5876695__F6 Meta-network illustrating synergistic interventions and resistance mechanisms to PI3K inhibitors 4609 5087 3169 8085 6446 2309 1017 596 572 PMC5877528__F6 The AR induction pathway in ‘T337’ basal cuttings 5640 1191 407 367 7504 2597 PMC5882306__F5 Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells 23595 81620 990 4999 23594 5000 8318 10926 8317 4998 PMC5884276__F1 Characteristic enzymes for the synthesis of isopentenyl diphosphate (IPP)/dimethylallyl diphosphate (DMAPP) and the formation of the isoprenoid diphosphate chain 3423 727 3652 907 PMC5891635__F1 Two working models explaining Sgg association with colorectal cancer (CRC) 4513 1499 6555 PMC5892236__F1 Resveratrol inhibits the mTOR signaling pathway in the repair of SCI 3667 2475 253260 7249 6009 9776 PMC5895746__F2 Schematic representation summarizing the functional effects of the three regulatory pathways controlled by IL-1B 11141 3553 4204 2475 8190 5978 PMC5896787__F2 Emerging concepts for immune checkpoint blockade-based combination therapies 1374 3932 940 7535 5091 PMC5899024__F6 For Therapeutic Targeting of AKAP Signaling Complexes in Nervous System Disorders 4478 120892 1270 627 PMC5902686__F7 Putative metabolic pathway of drought stress responses in flag leaves and developing grains of Zhongmai 175 367 847 2597 3652 2695 3426 PMC5908872__F5 B-cell receptor signaling pathway 613 4067 2885 8915 1040 759 126669 PMC5917100__F1 Viruses and the Autophagy Pathway 8878 359710 9342 PMC5923449__F2 EV71 induces multiple cellular inflammatory signals and Ca2+-dependent signals 6714 10454 23118 257397 4513 3725 1950 PMC5925819__F2 CDP-DAG and Kennedy pathways 8760 1040 100379198 780904 5662 PMC5935098__F3 Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye 6120 4286 6657 4771 PMC5936719__F1 Summary of unfolded protein response 22926 83939 7494 468 PMC5937267__F1 Finally, expression of T-cell co-stimulatory and co-inhibitory receptors can be modulated by hypoxia as well 56477 50943 8205 PMC5938286__F2 PD-1/PD-Ls signaling pathway 324 7535 2475 PMC5938338__F7 Schematic of Ca2+signaling pathway activated by alkaline stimuli to dentin surface and PLC-coupled receptor activation in odontoblasts 8989 367 847 PMC5938400__F1 Mechanism of action of pharmacologic therapies 9101 1956 7975 PMC5944225__F9 Magnoliae Cortex and maize modulate Porphyromonas gingivalis-induced inflammatory reactions 6774 4513 3553 PMC5953011__F1 Mechanisms regulating the canonical and non-canonical Wnt pathway 85358 324 1859 847 6907 57680 PMC5955117__F6 p53 and metabolism: from mechanism to therapeutics 2475 3579 1869 57103 PMC5956974__F11 Function of the hub genes in the cell cycle signaling pathway visualized in the Kyoto Encyclopedia of Genes and Genomes (KEGG) map obtained by the Database for Annotation, Visualization and Integrated Discovery (DAVID) 4118 5111 100187761 4342 PMC5958133__F6 Gene transcription in key nutrient metabolic pathways involved in lipid synthesis between L 2597 10554 10555 1737 6319 355 PMC5961053__F1 Production, elimination, and signaling of ROS 6648 6647 57716 PMC5962346__F1 Molecular targets for therapy in the HH pathway web of collaboration 6608 51684 7124 1950 2475 4018 4485 9113 847 23462 595 64399 898 PMC5968394__F2 PI3K/Akt signaling facilitates ROS detoxification and redox homeostasis 5163 6446 2932 9817 2539 PMC5977762__F2 Up-regulation of the JAK-STAT and mTOR pathways: Ingenuity pathway maps for a JAK-STAT signaling (transducing extracellular signals to transcriptional responses) and b mTOR signaling (a master regulator for many fundamental cellular repair processes) 2520 3630 7249 5091 3565 1610 6955 5972 PMC5979540__F7 Signalling pathways regulating pluripotency of stem cells regulated by detected differentially expressed miRNAs depend on muscle mass 79923 6657 7008 100653366 9242 3623 3845 324 PMC5979596__F3a GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance 2674 1020 2534 PMC5983649__F1 Schematic overview of Annexins at the crossroad of late endocytic pathways 6009 153129 10228 10948 4864 857 PMC5985952__F7 Sequential activation of polyadenylation during oocyte maturation in Xenopus 5225 23369 4661 4342 1977 5073 PMC5989766__F8 Impaired Akt signalling leads to iron accumulation 6647 351 5093 PMC5992506__F2 Cholesterol synthesis and cancer cell proliferation 857 1956 8178 PMC5994134__F4 Reconstruction of metabolic pathway of Woesearchaeota in the central carbon (a) and comparison of genes relating to the ferredoxin-dependent pathways between organisms from oxic and anoxic biotopes (b) 1358 8775 1314 PMC5995256__F5 Pathways altered in brain metastases compared to primary NSCLC 2885 3611 5728 5163 4170 11140 7248 572 7249 6009 1499 8231 79923 1977 PMC5996030__F2 Possible autophagy signaling pathways in traumatic brain injury (TBI) 2475 1728 7099 PMC6000924__F2 Summary of the putative mechanisms of mutations in the LRRK2 ROCO domain 55669 9927 55737 4976 PMC6008129__F1 Potential mitochondrial derangements that may be present in pulmonary hypertension are many and varied 7222 7351 6648 6774 PMC6013765__F3 “threshold model”, as exemplified by the FGF8-FGFR system, can explain disparities in transcriptional activity 10818 2020 57704 PMC6017457__F3 Schematic representation of the unfolded protein response pathway 22926 83939 468 2922 PMC6019623__F2 Synovial cell metabolism and chronic inflammation in rheumatoid arthritis 2475 4609 3091 PMC6020658__F3 Pathway mechanisms underlying CHMs improve lipid metabolism in liver cells 3931 3131 3949 5465 255738 64240 355 PMC6025041__F1 Hexosamine biosynthesis pathway 2821 55577 5238 6675 8473 10724 PMC6025041__F4 Metabolic pathways influenced by transcriptional factor O-GlcNAcylation 355 10724 8473 6667 PMC6025249__F7 Schematic diagram showing the mechanism of action of TFs against LPS-induced acute liver injury 9817 2194 2729 2730 3553 3146 PMC6029073__F1 Schematic diagram of the Sho1-dependant branch of the yeast high osmolarity glycerol (HOG) pathway as a model system for analysis of short linear motif function in signal transduction 998 55746 8466 PMC6030972__F6 Interactive KEGG diagram for Signaling pathways regulating pluripotency of stem cells 100653366 2885 572 6929 8178 1878 3624 3492 2932 100188835 7975 7054 100187761 7038 1312 3265 PMC6034133__F8 Inflammation leads through PGE/EP 3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes 7074 10014 5879 PMC6040288__F9 Network pathway: pathway enrichment analysis was performed 351 2242 57142 4023 637 8772 7124 348 PMC6042022__F7 Interactions between membrane–lipid metabolism, APP processing and Beta-secretase (BACE) activity, cholesterol uptake/efflux and cell cycle regulation 6285 351 348 23621 9619 3949 1164 64065 1017 5347 PMC6051890__F32 The diphthamide biosynthetic pathway and the mechanism of diphtheria toxicity 285381 1801 1802 51611 PMC6053305__F10 PERK signaling pathway in modulating skeletal phenotype 468 6662 26291 PMC6053318__F2 Everolimus and Sirolimus in Transplantation-Related but Different 3667 5163 5728 7249 7248 4193 6009 572 51466 6345 1977 6194 PMC6059118__F1 USE1 is a critical ubiquitin-conjugating enzyme in lung cancer cells 55850 55236 5999 PMC6060635__F1 Expanding complement therapeutics for the treatment of paroxysmal nocturnal hemoglobinuria 718 727 735 716 PMC6064680__F1 Model cell illustrating the Gq-mER signaling pathway in hypothalamic neurons 5443 859 4852 PMC6069411__F1 Canonical Hh signaling pathway 6608 51684 2932 2736 PMC6069411__F2 Canonical Wnt/Beta-catenin signaling pathway [,,,,,,,] 324 2932 607 10642 4118 960 6657 4316 PMC6071762__F1 Biosynthesis of glycerophospholipids and sphingolipids in mammalian cells 5091 95 283871 PMC6077868__F7 TGFB-dependent signaling implicated in fibrosis process 8877 387 2475 PMC6098640__F5 The pathway through which IL-33 stimulates the proliferation signaling of CRC cells 90865 6761 4513 PMC6099083__F5 Tumor Epigenetically Upregulated Genes (EUG) in Epstein-Barr Virus Infection pathway 4193 6908 958 960 3718 7189 4734 3458 3661 3586 6774 100187907 PMC6125328__F1 Signaling via MALT1 downstream of various receptors and CARMA/CARD proteins 613 126014 6714 6850 64170 8915 10892 1540 759 PMC6125421__F2 Signaling pathways of the unfolded protein response 22926 83939 7494 468 PMC6126897__F2 Functions of iTreg in the TME 84890 7939 5728 50943 2475 PMC6131612__F1 PI3K/Akt signaling pathway in HI 5728 2475 596 581 PMC6134416__F1 小细胞肺癌的的分子发病机制 581 1019 1017 PMC6139279__F1 ROS signaling and ER stress in cardiovascular disease 22926 7494 83939 468 PMC6149701__F1 Dual Regulation of NFKB signaling by SIRT6 51548 6502 6839 PMC6152364__F4 Relation between mammalian MAPK cascades and other kinases capable to induce cell responses involved in cancer 998 5879 2475 PMC6165247__F1 Consequences of endoplasmic reticulum stress response pathway 2475 6009 468 7494 PMC6165336__F11 AAP-H and the PI3K/AKT/mTOR signaling pathway 581 572 2475 PMC6168163__F2 Maintaining maximal metabolic flux by gene expression control 101448070 1401 7018 8178 PMC6171019__F1 Signaling pathway with PLD1 participation was activated in LNCaP cells in the androgen-free environment 5337 5091 2475 572 PMC6181017__F9 Suggested Schemes for PGI1-Mediated Biosynthesis of MEP Pathway Isoprenoid-Derived CKs and GAs in Cells of Vascular Tissues, and FAs and Proteins in Mixotrophic Maturing Embryos of Arabidopsis 2875 2597 3652 7956 PMC6181582__F3 Protein based pathway mapping of the patient response in the serum to antibiotic treatment 336 5360 338 3258 920 121599 10855 7054 4535 4060 8455 3273 350 5447 5624 3931 348 PMC6186589__F1 Schema of sortilin regulating EGFR trafficking () 1956 6010 10551 4919 2475 11021 2060 PMC6191511__F1 Functional analysis of genes differentially expressed in response to L-lactate after 1 h 4137 2122 6955 4149 23632 5598 6722 4613 1385 7054 4117 4790 PMC6193074__F10 Cardioprotection by AsIV through CaSR/IP3R pathway 846 572 2626 1738 PMC6193676__F1 Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast 1801 51611 89978 92715 PMC6198234__F5 Proposed mechanisms by which PKM2‐mTORC1 regulatory pathways contribute to resistance in RCC cells 5163 5728 253260 2475 PMC6199630__F15 Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis 325 472 3014 2237 1956 7518 PMC6204952__F4 GC-C activation, intracellular effects 1080 3458 3553 PMC6205410__F2 Downstream products of ROS promote endothelial cells (ECs) dysfunction in atherosclerosis 6009 2475 10365 PMC6221911__F1 Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models 43 627 2475 4853 142 81847 596 PMC6224709__F4 Central carbon metabolism pathways in daf-2 and eat-2 mutants 2203 5230 5236 5106 4191 285148 50 PMC6244246__F5 Integrated transcriptomics and metabolomics pathway diagrams 8443 1120 54947 1606 4018 350 1208 95 4099 PMC6244318__F1 KEGG insulin signaling pathway identified by WebGestalt from the bta-miR-486 target gene list 355 2308 3643 3630 7249 572 1977 2885 PMC6261125__F6 Transcriptome-wide identification of genes involved in Ascorbate–Glutathione cycle (Halliwell–Asada pathway) and related pathway for elucidating its role in antioxidative potential in finger millet (Eleusine coracana (L.)) 6295 7939 4049 PMC6269465__F1 Effect of SPPL2a deficiency on IFNG machinery 84888 324 920 PMC6270750__F1 Astragaloside biosynthetic pathway 9961 3652 4597 PMC6273124__F1 PI3K-Akt-mTOR pathway 5163 5728 7248 7249 PMC6274341__F1 Isoprenoid biosynthetic MVA pathway in the plant cell 3652 4598 9961 PMC6274950__F10 Correlation networks of main potential biomarkers in response to T2DM rats 1401 9021 3553 PMC6277481__F1 Genetics and molecular pathways for PPGLs Pathways for the New Genes; Placing the New into Perspective 5979 4149 3265 317 55654 4609 4351 546 6651 54949 PMC6277997__F6 Mechanisms of DMTN in the invasion and metastasis of CRC 5058 9181 2039 5879 PMC6279876__F4 Schematic model of HPV-driven carcinogenesis 1869 1019 1871 23411 1021 PMC6280292__F8 Antitumor effects of emodin and chrysophanic acid 6667 1956 2475 PMC6282138__F6 Proposed mechanisms of lipoprotein uptake and Fluocinolone acetonide effects on inflammation and lipid accumulation in THP-1 derived foam cells 2642 2638 948 PMC6287696__F1 The mechanism by which Rel/NFKB-dependent STING expression activates antiviral autophagy to restrict ZIKV infection in fly brain 9474 10533 5966 PMC6291014__F4 A model of EphB forward signaling regulating cell-ECM adhesion 5879 4313 2048 PMC6298397__F3 Central metabolic pathway of representative carbon sources in model iZBM1060 (detailed information on enzyme information and reactions are presented in Supplementary Table ) 4200 2695 4118 3791 11113 PMC6304490__F2 Examples of in vitro molecular action of quercetin (Q) in cited cellular experiments 7454 7039 4312 367 2353 3725 PMC6306440__F1 Abnormalities in the DNA damage repair pathway in T cells of rheumatoid arthritis patients 4361 545 472 PMC6306737__F1 Metabolic pathway of lipid metabolism in muscle 1376 717 28976 1101 PMC6319725__F10 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells 7097 10135 3550 PMC6321330__F1 Simplified representation showing the interplay between the major signaling cascades activated by tyrosine kinase receptors (RTKs) and TSH-Receptor (TSH-R) 780 7253 2475 PMC6321468__F1 The polyphenols’ major mechanisms of action on colorectal cancer (CRC) cells 1499 4513 1017 PMC6322225__F2 Health to disease (HTD) network 27040 5753 7124 4862 PMC6322652__F1 mTORC1 and mTORC2 as regulators of cell metabolism in immunity 5728 5170 6446 7249 7248 6009 PMC6325765__F6 Central carbon and Gamma-PGA production pathways 6120 11113 1431 2752 4118 PMC6325856__F10 The proposed cardioprotective mechanism of mAb A treatment in hearts following a myocardial infarction 2475 2932 28999 PMC6329746__F6 Molecular signaling pathways relevant to the resistance to MAPK pathway inhibitors 2475 1021 1019 6194 PMC6329923__F8 Proposed model of the mechanism of GALNT6-mediated regulation of proliferation and metastasis thought Beta-catenin /MUC1-C signaling in breast cancer 11226 324 1499 595 PMC6331581__F5 Predicted metabolic pathways of phylotypes NkOx7-01 and NkOx7-02 1314 729 275 PMC6332435__F1 An overview of cellular endocytic mechanisms 387 382 998 375 PMC6332805__F2 Different types of autophagy 9140 9474 22863 PMC6333678__F2 Signaling pathways activated after binding of E2 and G1 to GPER 100124700 1950 1956 4485 6714 595 PMC6335102__F10 Renal ion regulation in response to ANG II 367 3717 9368 1638 65266 PMC6337474__F1 Top left: Wnt binds to the Frizzled receptor (Fz) and the LRP5/6 co-receptor 5741 1499 9242 650 PMC6338564__F5 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses 4609 5625 5831 10135 4942 2744 23411 PMC6345046__F5 Relationship between autophagy and cytokines 2475 7098 9474 7099 11337 7189 PMC6348405__F1 Mitochondria-to-nuclear retrograde signaling pathways in mammals 762 468 9817 PMC6348597__F1 The signaling pathway implicated in VIDD development 7099 6714 2475 PMC6351700__F2 Signaling model in a cell during tumor formation 220323 7249 6009 2475 PMC6351700__F3 Schematic/proposed signaling model of role and regulation of claudins in a cell during invasive or metastatic stage 324 4040 4041 1956 7124 7248 6714 2475 6009 PMC6353800__F1 Schematic overview of major enzymes and metabolites involved in the regulation of gluconeogenesis 7038 5091 5183 PMC6354897__F1 Key pathways interacting with theMEP pathway in chloroplast 4015 1431 717 PMC6355880__F8 Model describing the distinct fates of NK cells during NK cell education 200576 847 5266 3002 759 PMC6356359__F6 Proposed epigenetic model of colonic inflammation and carcinogenesis associated with long-term exposure to a diet high in n-6 fatty acids (n-6HFD) 324 1499 595 PMC6357680__F9 Selected enriched KEGG pathways among DETs between S41 and S43 during tail resorption 351 174 3952 8772 847 5185 PMC6359907__F4 Selective autophagy as a potential therapeutic target for neurodegenerative disorders 5914 7942 23239 9140 PMC6360516__F7 LIMK2-Mediated Cofilin1 Phosphorylation Signals TGFB1-Induced GC InsensitivityPhospho-cofilin1 is implicated as a key link in the chain of signalling behavior of TGFB1-induced GC insensitivity 998 3985 4018 PMC6361976__F1 The largest gene regulatory subnetworks in yeast 9541 51077 106049960 PMC6361976__F2 The pertinent features of the phosphocholine pathways 5337 5091 1040 84249 PMC6362265__F1 Three branches of the unfolded protein response (UPR) 22926 7186 83939 1998 468 PMC6364417__F7 Pathways affected by the combined selected kinase inhibitors in BRAF mutant melanoma cells 7465 1019 1674 PMC6365902__F3 mTOR signaling pathway, which may be dysregulated in TNBC 2475 220441 83667 64798 6010 5728 6009 7054 PMC6367250__F1 The roles of circRNAs in cancer phenotypes and biological characteristics 1499 7078 2309 PMC6375688__F1 Proteostasis regulation 83939 468 22926 PMC6375884__F3 A schematic representation of main processes involved in rice drought memory response 4969 100653366 4609 4602 2077 PMC6378136__F2 Endosomal sorting and trafficking, the retromer complex and neurodegeneration 55737 351 23621 PMC6381062__F2 A working model of NPR1, NPR3, and NPR4 4881 6612 4883 8452 PMC6381369__F1 An illustrated view of Netrin-UNC5B signaling 5747 5578 3725 50632 249 6401 759 81501 56963 PMC6382702__F8 Clavulanic acid biosynthesis is regulated by the TCS CagRS 25801 790 4942 PMC6382829__F5 ZINC24469384 regulates genes involved in P53 and STAT signaling pathways 759 1869 2885 2475 1051 3725 3569 100187907 PMC6384614__F5 Biosynthetic pathway for the capuramycin-type nucleoside antibiotics 643414 822 828 351 PMC6387057__F1 Schematic depiction of the mTOR signaling network 2475 64798 6009 6497 790 7942 PMC6388657__F6 IPA to identify the signaling pathway associated with the differentially expressed proteins across all the conditions studied 7008 5345 3075 197 7054 7276 PMC6389705__F1 Intrinsic and extrinsic pathways of neutrophil apoptosis 7124 8772 8717 637 PMC6391709__F5 PI3K/AKT/mTOR and ERK signalling pathways associated with cardiac hypertrophy 3667 5163 207 5728 7248 PMC6391774__F4 Levels of regulation of NKG2DL expression 1950 7124 2475 3297 6667 PMC6411635__F2 Metabolic reprogramming of T cells after allogeneic stem cell transplantation 3101 3099 2475 355 PMC6412864__F3 Apoptotic signaling during ER stress 83939 468 7186 PMC6423427__F1 Overview of UPR signaling pathway 22926 7494 83939 468 PMC6423448__F1 Key components of the Hippo pathway in Drosophila and mammals 4771 4485 26524 PMC6423516__F2 Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss 7942 4067 9140 55054 8408 9474 9776 PMC6423593__F6 Pathview graph for the Kyoto Encyclopedia of Genes and Genomes term ‘calcium signaling pathway’ allows the visualization of the differentially expressed genes involved in this signaling pathway 90550 5350 858 859 613 952 1356 857 PMC6424728__F1 Promoting immune evasion by Hippo pathway 1956 1950 3579 6374 PMC6429583__F2 Homology of the GSH synthesis pathways in mammals and Caenorhabditis elegans 2729 2730 2638 PMC6431505__F6 Schematic graph of the proposed cardioprotective mechanism of H2 when rats were exposed to CIH 22926 7494 2922 468 83939 PMC6436646__F2 Calcium signaling pathways and their effects on the calcium responsive percentage of chondrocytes 59341 4827 1506 PMC6437095__F3 Interaction between miRNAs and FSH pathway in GC 2885 5163 3973 2492 627 406992 207 10000 2475 PMC6438438__F8 Diagram demonstrating the unfolded protein response pathway and downstream chaperone proteins 7494 83939 468 PMC6438456__F10 Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers 1956 5728 324 2932 253260 2475 64223 1499 759 2002 PMC6440158__F9 A working model of circPPP1R12A-73aa on promoting tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway 4485 9113 26524 PMC6441234__F1 Illustrative diagram for exosome-mediated transfer of therapeutic resistance in the tumor microenvironment (TME) 54033 283120 1786 1956 7251 967 928 5728 PMC6442448__F13 Mechanism by which GBE attenuates diabetic atherosclerosis 22926 7186 83939 468 9140 2475 7494 PMC6444613__F1 Metabolic pathway of propionyl-CoA and methylmalonyl-CoA 55788 3416 23624 27249 868 4552 23774 PMC6446925__F1 AMPK Signaling Pathway 100034703 29904 1938 7216 PMC6456539__F2 Activation of autophagy process by extracellular vesicles 10533 1956 2475 6774 PMC6456712__F1 MHtt aggregation, generation of ER stress and the consequent UPR protective and later pro-apoptotic responses 22926 9817 83939 468 PMC6458279__F1 Apoptosis pathway and potential targets for pharmacological modulation 7097 7099 8772 948 2309 572 27429 2021 581 PMC6458279__F7 Autophagy pathway and potential targets for pharmacological modulation 7942 10533 9140 9474 83734 7038 PMC6461634__F5 Proposed de novo synthetic pathway of monorhamnolipids in Pseudomonas guguanensis 759 95 8454 PMC6468297__F1 Cell stress-dependent regulation of alternative initiation of p53 mRNA translation 4193 581 472 PMC6468556__F4 Model for HCV assembly and release 51099 84649 8694 57762 348 PMC6477733__F3 Transcriptional reprogramming of the H-series strains H14, 20, 27, and 31 at 24 h post-induction of gene expression 3008 6886 130 25913 52 2195 6867 PMC6478727__F2 Differentially expressed coat color genes in Changthangi Pashmina goat and their involvement in melanogenesis signaling pathway (Adapted from ref.) 4286 1499 1638 7306 PMC6479341__F1 The role of unfolded protein response (UPR) in cell survival upon induction of ER stress 22926 83939 468 PMC6479968__F1 Protein C activation by the thrombin-thrombomodulin complex and the cytoprotective function of Activated Protein C (APC) in ischemic heart disease and heart failure 5091 324 5879 PMC6488142__F1 PI3K/Akt /mTOR pathway 5728 2475 7249 7248 6194 PMC6489690__F4 MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer 4018 4485 11178 983 55233 9113 PMC6492940__F5 Inflammation, apoptosis and cell survival 6770 2852 2021 581 317 1499 PMC6497933__F6 Summary of the DEPs involved in central carbon metabolism and fatty acids synthesis 2539 2444 4118 11113 PMC6518354__F1 Schematic drawing presents the detail signaling pathways of endometrial carcinogenesis 1499 324 1950 2475 5728 572 6714 PMC6523117__F7 Suggested mechanism of rFlaA:Betv1-mediated mDC activation 7100 4615 3654 51135 7189 2475 6774 PMC6523735__F6 Proposed model for miR-130a downregulation of HCV infection 9474 5313 9140 PMC6525084__F3 RNA-seq identifies synergistic (GxE) genes, which are enriched in NF-kB signaling pathway 3932 7186 6908 PMC6527025__F5 Apoptosis Signaling During Influenza A Virus Infection.IAV infection affects apoptosis in early and late infection 54894 637 10013 572 1191 581 3553 PMC6530577__F1 Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis 22926 7494 83939 468 PMC6531411__F1 Diversity of the effects of DJ-1 in cell 9817 10210 7054 1644 5728 581 1215 PMC6535379__F1 Signaling pathways involved on induction of endoplasmic reticulum (ER) stress 22926 83939 7494 468 PMC6535785__F7 Probable molecular mechanistic pathway of ruthenium baicalein complex 5111 2475 581 836 PMC6540047__F5 BRO priming of interferon response pathway in the absence of virus 8772 8737 7187 9636 57506 10379 29110 2994 3661 5300 338376 PMC6542591__F1 Adaptive and pro-apoptotic pathways of the UPR 22926 7494 83939 468 PMC6544049__F1 Circadian rhythms and memory formation 1629 8864 9575 1408 1407 PMC6547588__F5 Involvement of LOAD risk factors at the BBB 348 5243 5879 4035 8301 23607 PMC6549079__F3 Signaling pathways related to RUNX1 2064 1950 2932 1499 1956 861 PMC6550017__F5 GLI proteins are regulated by PKA 23432 6608 156 157 158763 PMC6551314__F8 Proposed model for the role of Them2 in hepatic VLDL secretion 7038 137964 4018 8694 84649 PMC6558396__F1 Drosophila Hippo pathway Network 10207 64398 23558 7791 3535 23513 PMC6563036__F3 Proposed mechanism between mTOR Signaling Pathway, Inhibitors and Photodynamic Therapy (PDT) 5163 5728 7248 7249 64798 253260 64223 PMC6567800__F6 Anti-apoptosis mechanisms of molecular hydrogen in sepsis 7099 4615 2932 PMC6568242__F2 Transcriptional Regulation of Proteasome Subunit Genes 10413 4899 23304 414301 84301 PMC6571165__F2 Signaling pathways that contribute to CF activation and stress response 1956 156 387 6722 23476 3065 PMC6571408__F9 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MAGE A11 in patients with esophageal squamous cell carcinoma (ESCC) 7124 2475 8213 PMC6584916__F7 Roles of Slit/Robo in angiogenesis 9353 54538 6091 219699 PMC6586490__F1 Mitochondrial dysfunctions in Barth syndrome 9489 283871 10306 PMC6587703__F2 Mechanistic interactions between VEGF-targeted anti-angiogenic therapy and checkpoint inhibitors in the systemic treatment of mRCC 2885 2549 998 7039 7428 5728 51083 940 595 PMC6588884__F2 MET protein structure (a) and HGF/MET signaling pathway (b) 3082 2885 2549 PMC6590237__F1 Dorsal root ganglion (DRG) neurons branch out to the skin with transient receptor potential channel vanilloid 1 (TRPV1)/transient receptor potential channel ankyrin transmembrane protein 1 (TRPA1) and other receptors expressing 4803 8989 7442 PMC6590704__F1 Nuclear gene-encoded regulatory factors are essential for mitochondrial biogenesis and function 7019 4899 23411 PMC6593125__F1 T-cell receptor (TCR) signaling 3932 1445 2885 8205 27040 PMC6598962__F6 Cooperation of 17-aminogeldanamycin (AG) and trametinib (TRA) or vemurafenib (PLX) a A schematic summary of molecular effects of TRA, and PLX activity, and 17-aminogeldanamycin-mediated HSP90 inhibition in melanoma cells 6955 673 83939 1939 468 7494 22926 PMC6599034__F2 Label propagation defines signaling networks associated with recurrently mutated cancer genes 27343 4609 200558 7015 23013 2548 545 472 580 9575 2305 1000 5347 2475 1356 130589 6770 100187761 27434 266710 PMC6600269__F1 Survival signaling pathways related to the PI3K/Akt pathway in mouse macrophages 5163 5728 7249 7248 6009 572 596 PMC6608034__F3 MTORC1 pathway: effect on TLR signaling cascades and modulation by bacteria 4615 7248 7249 6774 PMC6611515__F4 Comparative RNA-seq analysis reveals dys-regulation of major canonical pathways in ERG-inducible LNCaP cell progression model of prostate cancer 23595 10926 8318 4999 1019 993 5933 PMC6611711__F1 Lipid biosynthesis in cancer cells 7038 355 2475 6319 55902 47 8402 PMC6612148__F3 CK2 actions on chaperone machinery (a), NFKB signaling (b), and PI3K/AKT/PTEN pathway (c) 11140 4851 5728 PMC6615313__F6 Metabolic context of the reconstructed σ54 regulons in Clostridiales species 4810 100270804 2109 2108 100653365 3045 100187828 PMC6617290__F1 Model that proposes the form in which physical activity activates the nuclear factor erythroid 2-related factor 2 (Nrf2)–Keap1 pathway 8452 9817 4094 PMC6627365__F2 Epidermal Growth Factor Receptor-dependent activation of the MAPK signaling pathway 1950 1956 1380 2885 PMC6627638__F10 Epigenetic regulation of survivin in transformed cells 1786 22992 9682 PMC6628025__F1 Fibroblast growth factor receptors (FGFRs) are highly conserved transmembrane receptors consisting of three extracellular immunoglobulin-like (Ig-like) domains, a transmembrane helical region, and a cytoplasmic region with kinase activity 10818 2885 2549 6955 PMC6629629__F2 Clinical update on head and neck cancer: molecular biology and ongoing challenges 1956 3082 2885 5728 2475 4193 PMC6629629__F3 Clinical update on head and neck cancer: molecular biology and ongoing challenges 1956 2475 1029 1021 1019 4193 1017 PMC6640532__F1 Ubiquitin/26S proteasome system (UPS) 6185 9978 6500 PMC6650552__F6 AnvM-mediated regulation and its interaction with host cell 7100 7189 7097 3553 PMC6651977__F1 The ER stress pathway 7494 83939 22926 468 7466 6262 PMC6657305__F3 Cellular Compartmentation and the Redox/Nonredox Functions of NAD+ 2597 952 23098 65220 25961 PMC6659691__F2 A modeled signaling pathway using a G Protein Coupled Receptor activation as an example 23440 367 2778 PMC6664092__F6 Overview of QTG involved in organoleptic compound production 84944 4191 6502 PMC6668790__F6 Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo 5442 81892 55149 PMC6675248__F2 Cell signalling dysfunction in mTOR signalling pathway leading to syndromic and idiopathic autism 5728 4763 5163 7248 7249 6009 1978 PMC6675305__F4 Genes enriched in the VS (shaded) are contained in the canonical pathway for Ras/MAPK signaling 1398 2534 6714 4342 55845 572 6722 6772 PMC6681663__F1 Everolimus for the treatment of advanced pancreatic ductal adenocarcinoma (PDAC) 5163 5728 253260 2475 6009 2000 PMC6683665__F3 Positive and negative regulatory events in shrimp Toll pathways 54472 7189 4615 PMC6683665__F4 Comparison of the shrimp IMD pathways (A) and Drosophila IMD pathways (B) and Human TNFR signaling (C) 23118 8772 8717 257397 PMC6683665__F5 Interplay between shrimp NFKB pathways and WSSV 7189 4615 23118 PMC6687759__F3 Proteoglycans in cancer-predicted pathway 1956 7097 1634 4609 7422 867 4060 759 PMC6696055__F2 Regulation of autophagy by ROS 472 8408 9474 9776 22863 5728 PMC6696356__F7 Scheme summarizing the protection of AB25–35-induced SH-SY5Y cell mitochondrial dysfunction by ginsenoside Re via inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response pathway 581 4094 2729 PMC6698799__F3 Proposed interaction model of Yersinia pestis effectors, Yops, with the pyrin inflammasome 6010 4598 5586 5585 PMC6702836__F6 Partial pathway reconstruction of genes involved in lipids, nucleotides and vitamins metabolism 1611 5091 5053 1356 PMC6704558__F2 Signaling pathways for CSF-1 and FAK 6714 998 4193 PMC6715251__F9 Adenovirus early region 3 RIDA protein limits NFKB signaling through stress-activated EGF receptors 1956 83547 5300 PMC6715851__F2 Differences in the carbon flux distribution in oleaginous rhodococci under nitrogen-rich and nitrogen-poor (TAG accumulation) conditions 355 1401 4841 PMC6719526__F4 Metabolic reconstruction of the isolated strains Halonotius terrestris sp 23242 64326 637 PMC6721652__F1 Canonical WNT pathway in on and off states 1499 324 4040 PMC6721652__F3 Canonical WNT pathway components associated with disease 1499 324 4040 PMC6726644__F9 Schematic overview of metabolic pathways of P 1760 3073 5978 275 1611 7276 7808 PMC6734673__F2 Epidermal growth factor receptor Pathway and its two pathways: Ras/Raf/Mitogen-activated protein kinases or PI3K/AKT 1956 2885 5728 2475 PMC6738830__F6 Proposed model for impaired apoptotic response to hMPV infection in NECs from asthmatics 581 83939 468 PMC6741067__F14 The signaling cascade activated by the CaSR that induces the arrival of ZO-2 to TJs 65266 5091 846 PMC6747374__F8 Signaling pathways involved in the AVP-dependent myogenic differentiation 551 2475 9759 PMC6748048__F1 Kinase Activation Mechanisms in the Hippo Kinase Cascade 60485 4771 26127 7871 6801 PMC6748367__F6 KEGG Pathview readouts of DEX vs Control-associated differential gene expression 324 5290 2064 1956 PMC6755737__F1 The central carbon metabolism of C 5805 5183 4397 PMC6769649__F3 Ligand-dependent EGFR signaling pathways 1950 1956 2885 6714 867 PMC6770048__F1 Proposed biosynthetic pathway leading to multiple terpenoids in I 65985 4598 3652 5640 PMC6770178__F1 Substance P/neurokinin-1 receptor (SP/NK-1R) system regulates several cell signaling pathways involved in cancer progression 324 2475 2932 1499 5163 6010 8549 PMC6770252__F2 Three major branches of the Unfolded Protein Response (UPR) signaling pathway and their interconnections 7186 83939 7494 468 22926 PMC6771382__F2 Summary of HR processes and HR proteins reported for sumoylation and interacting with SUMO 9156 5893 5888 118027463 80010 84464 6495 6496 10736 51804 PMC6779911__F2 Functional annotations of highly nitrate-sensitive (HNS) gene set and model of nitrate assimilation and regulatory components in Phaeodactylum tricornutum 10 1431 7038 7018 4841 PMC6780043__F4 Effects of nanomaterials (NMs) on Ca2+ channels located on the cell membrane and Ca2+ stores and subsequent dysfunction of ion homeostasis 129521 6786 2475 PMC6784043__F2 Crosstalk between different PRRs in antifungal immunity 6850 64170 114548 3553 4615 3659 4193 85451 PMC6785598__F4 Epigenetic regulation of stem cells 9314 1788 11201 9055 6996 54790 6965 1786 4200 PMC6797793__F1 A schematic of the tanshinone biosynthetic pathway 3652 340451 1356 PMC6798326__F9 TSHR mediated signaling induced OF proliferation through Akt signaling and induction of miR-146a and miR-155 7253 5728 84133 PMC6805690__F4 Notch-induced autophagy and translational noise as destabilizers of cellular memory 5728 2475 2932 4609 4175 4171 PMC6813133__F3 ADHD gene-networks constructed with PASCAL associated genes and its FunCoup interactors 6790 29079 6950 29882 9133 51053 PMC6813250__F3 JA-mediated cold and freezing stress responses in plants 23379 79664 1603 PMC6814454__F2 Substrates of PD enzymes identified by proteomics.(A) The PINK1-parkin mitophagy pathway 65018 120892 2664 PMC6822533__F1 Engineering anti-cancer nanovaccine based on antigen cross-presentation 8766 9554 2241 PMC6829426__F13 A potato plant’s response to weak light and exogenous Ca2+ 847 11113 717 PMC6829482__F7 The role of MyoF during skeletal muscle development 26509 324 1499 4656 PMC6830099__F6 Putative model for the role of WIP1 in HR and in PARP inhibitor sensitivity 672 142 10038 PMC6830338__F1 Transcription regulators (TRs) that modulate glycolytic metabolism in cancer cells 5728 367 2475 57103 2597 54625 PMC6831883__F3 Timing Analysis and Its Results for the Citric Acid Cycle(A) Timing analysis 9241 11113 4118 1506 PMC6834311__F2 The most common signaling pathways influenced by probiotic strains employed in C 1499 5163 207 208 10399 PMC6863093__F2 PD-1 exerts intrinsic suppression of T cell activity proximal to the TCR: 324 940 7535 PMC6877939__F1 Overview of PI3K/AKT/mTOR signaling pathway and downstream effects 1956 5266 5728 PMC6878783__F2 Astaxanthin improves insulin sensitivity and glucose uptake 3667 5879 10890 5872 51552 PMC6881331__F7 Molecular mechanisms of p53 loss of heterozygosity in breast cancer in response to DNA damage 2064 2475 3297 PMC6885181__F5 HIF-1-miR-219-SMC4 axis regulates proliferation and migration of HCC under hypoxic condition 1019 10051 1017 999 PMC6887802__F2 COPD and autophagy pathway 1958 2475 51083 64422 10533 8408 22863 9776 PMC6887802__F7 Acute lung injury and autophagy pathway 2475 8408 9776 PMC6889432__F2 Notch signaling pathways in CRC 57534 100188776 28514 182 7450 102 PMC6892558__F4 East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide 51083 7204 100306940 2160 PMC6894473__F1 Schematic view of the Wnt signaling pathways between MSCs and HCC cells in inflammation microenvironment 9242 3458 324 1499 4072 7015 8178 4040 4041 619501 PMC6894939__F5 Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? 2203 5106 5105 5091 PMC6895278__F4 Models for REV3-dependent synthesis at difficult-to-replicate regions in the genome 5111 5893 5888 PMC6895440__F2 Several typical post-translational modifications of PGK1 5230 2475 8841 1956 5300 5170 PMC6896012__F1 The KEGG calcium signaling pathway 90550 5350 857 858 3270 10345 613 1610 PMC6896028__F2 The Nrf2 pathway is regulated at multiple levels by different microRNAs 9817 8452 9978 693202 100302175 100500918 407024 PMC6899977__F3 The carcinogenic mechanisms of six major microorganisms 7054 6774 999 6608 PMC6900666__F7 mTOR signalling pathway identified by KEGG analysis of the target genes of the DElncRNA 2475 83667 220441 201163 64798 6009 9675 10682 1977 1975 6010 5728 9846 253260 PMC6904332__F4 The expression and effect of SESN2 on immune cells 7124 3553 114548 83667 PMC6912555__F1 Canonical and noncanonical Wnt signaling pathways 54894 84133 8658 324 6010 5879 1499 64840 51176 2932 6259 PMC6912706__F2 SGA-induced impairment in hepatic insulin signaling and glucose metabolism 3667 8660 2308 PMC6914774__F1 The emerging treatment landscape of targeted therapy in non-small-cell lung cancer 1950 673 5728 2475 PMC6917045__F2 Interplay between the UFM1 pathway, ER stress and cell fate 51506 79876 51569 468 6714 PMC6921210__F7 GEFT function and signalling pathway 5879 998 387 PMC6923788__F1 Signaling by the phosphatidylinositol-3-kinase (PI3K)-AKT- mammalian target of rapamycin (mTOR) pathway 2260 5163 7249 PMC6934083__F1 Autophagy regulates the expression of HDAC proteins which in turn leads to altered transcription and enhanced tumor cell immunogenicity 2475 9474 83939 3620 PMC6935429__F3 Different DNA repair mechanisms 80198 5111 56852 PMC6936066__F8 The explanation of TGFB regulates cell fate and plasticity as well as multifunctional cellular responses via SMADor non-SMAD pathways or ITGB1 pathway band with fibronectins and tenascin-C PI3K/AKT pathway 3688 3611 1499 PMC6936734__F1 Schematic representation of sphingosine-1-phosphate (S1P) pathway 8877 124976 6611 56848 PMC6941129__F4 Regulation of the G1/S transition by the Greatwall-Endosulfine-PP2A/Cdc55 pathway in budding yeast 1201 983 1017 PMC6943030__F2 Section from a pathway that describes the biosynthesis of Lewis-type epitopes by the bacterium Helicobacter pylori 85569 3240 100187761 PMC6944711__F3 Functional intersection of the GPCR-senescence system 3725 6011 4094 100187761 6955 26136 PMC6945043__F1 Embryonic origin of the E blastomere and simplified diagram of the gene regulatory network for endomesoderm specification in C 10940 9968 5469 101180900 4397 PMC6945981__F5 Effects of perlecan deficiency on transcriptome changes in (A) the 1-day study groups and (B) the 7-day study groups 1101 7450 920 4117 PMC6953096__F4 Representation of DEGs in major signal transduction pathways, in 5a treated cells 5447 6010 2475 2056 PMC6953127__F1 The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases 9706 10533 9140 64422 26100 PMC6953796__F4 Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34 157739 5091 5132 11113 PMC6955744__F5 TGFB signaling pathway with mediators in the TGFB pathway and BMP pathway are depicted, adapted from IPA 4838 6497 2885 7421 367 3224 145258 5308 3196 PMC6959120__F1 Simplified autophagy signaling pathway and regulation 10533 2475 8408 9140 9474 7942 64422 80317 PMC6963500__F9 Activation of the Wnt/Fz ligand-receptor leads to the production of the second messengers IP3 and DAG from membrane-bound PIP2 via the action of membrane-bound enzyme PLC 846 860 650 PMC6963578__F2 Schematic diagram of interactions between arenavirus proteins and host innate immune machinery 83939 3661 29110 PMC6966813__F3 Ubiquitination on mTOR signal affects the cross-talk between RAS-RAF-MEK and PI3K-AKT-mTOR pathways 2475 253260 55294 7249 6009 7189 5163 5164 PMC6972648__F5 Evidence for a role of protein phosphorylation in the maintenance of the cnidarian–algal symbiosis 267 7415 1406 7249 PMC6981390__F2 The biosynthetic pathways (terpenoids, bitter acid, phenylpropanoids and flavonoid) in the hop 586 3652 412 PMC6982094__F3 Exogenous GM3 and the EGFR-mediated PI3K/AKT signal pathway 1950 51083 581 2475 57097 PMC6992624__F3 An integrated computational and experimental study to investigate Staphylococcus aureus metabolism 1896 2695 5225 6120 5091 1431 5183 4118 4200 7851 443 4693 4199 7067 PMC6996360__F3 Genes involved in hedgehog, Wnt, TGF‐B, and p53 signaling pathways were differentially expressed during developmental BA 5727 6469 3092 6608 51684 324 PMC7000407__F2 Circadian rhythm in intervertebral disc degeneration: an autophagy connection 2475 8408 7249 83939 9140 468 9474 10533 64422 PMC7000863__F1 Unfolded protein response (UPR) pathway 83939 468 2475 22926 PMC7013532__F1 Pathway associated with terpene synthesis in Camellia sinensis 4598 3652 10763 355 8213 PMC7014214__F2 Anticancer mechanisms of phytochemicals on gastric cancer 545 4851 100188776 9140 999 468 4313 PMC7014934__F1 An overview of autophagy machinery 9776 60673 9140 9474 PMC7016420__F3 Metabolic reprogramming of HSC 26136 2806 84706 4118 PMC7016983__F2 Metformin (MET) AMPK dependent signaling 790 1975 1977 8408 7249 7942 5371 23216 6009 2475 PMC7017203__F4 ING proteins are involved in the DNA Damage Response 3621 4361 3622 9656 472 9025 84289 672 PMC7017275__F1 Simplistic model of the mTOR signaling pathway in cervical cancer 5163 1956 4609 64798 6446 1977 7458 PMC7019846__F2 Muscle protein synthesis and degradation signaling by omega 3 fatty acids (FA) 3667 7038 2475 1977 1998 PMC7021704__F6 Main pathways in O 5226 51083 5132 95 PMC7022462__F2 Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression 1499 2475 324 PMC7025494__F1 Cytoskeletal Regulation of the Hippo pathway in Drosophila and Mammals 154796 84962 999 PMC7028849__F8 Schematic illustration on possible roles of aminooxyacetic acid (AOAA) on macrophage metabolism and polarization 5211 7124 948 PMC7031145__F7 Phosphoinositide-3-kinase, phosphatase and tensin homolog, p38 mitogen-activated protein kinase and RAS pathways modulated by caffeine 1956 5728 2475 PMC7033203__F2 Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis 175 4598 4597 3652 340451 4397 PMC7037436__F8 Andrographolide biosynthetic gene activation by MJ elicitation in Andrographis paniculata 4598 253430 3652 PMC7042402__F4 Metabolic mechanisms of macrophage polarization 114548 3663 47 PMC7046483__F3 RANK/RANKL/OPG pathway in fatty acids‐modulated bone metabolism 7189 6714 3725 100187907 860 PMC7048048__F2 Directionality of transketolase 2 (TKT2) impacts the in silico essentiality of two genes encoding EDD and EDA from the Entner–Doudoroff pathway 84890 6120 1896 PMC7052942__F2 Verified signaling pathways of YWHAZ in HCC 558 4088 7534 9759 1410 10533 999 64422 PMC7056469__F4 Oxidative stress are targets of antioxidant dietary compounds 5212 847 9817 4968 2729 260431 PMC7056924__F1 Metabolic adaptations to acute metabolic stresses in the tumor microenvironment changes central carbon metabolism flow and exposes vulnerabilities 7428 3091 790 2744 948 10645 2475 PMC7063119__F1 Apelin/APJ system–mediated signaling pathways 9759 10014 10365 PMC7067140__F1 DYSREGULATION OF METABOLIC ENZYMES IN TUMOR AND STROMAL CELLS: ROLE IN ONCOGENESIS AND THERAPEUTIC OPPORTUNITIES 4609 2821 2813 9615 2271 2597 1431 2194 47 2744 6510 PMC7069334__F1 Simplified Galactomannan biosynthetic pathway in coffee seed 100034700 51083 3416 PMC7072214__F4 Apoptotic signaling pathways with the reported interaction of Rab proteins 8772 596 581 PMC7072222__F2 Nucleolar surveillance pathway 6125 4193 6135 PMC7072595__F3 Multiple mechanisms of SFRP1 involvement in Wnt signaling pathway 6422 2932 1499 324 PMC7072743__F2 Activation of the mechanistic target of rapamycin (mTOR) 3667 5163 6009 7249 7248 253260 2475 64223 PMC7074507__F1 TCR/CD3 complex and CD28 downstream signaling pathways leading to activation of transcription of genes for cytokines, chemokines, cell division, activation of effector function, and survival 1493 940 998 2475 PMC7078111__F1 HGF/c-Met signaling and lncRNA/miRNA/c-Met interaction 3082 2885 2475 84981 7503 PMC7084349__F1 Cellular mechanisms mediating activity-dependent translational control 2475 29904 1998 1938 PMC7097090__F3 Counter-regulatory renin–angiotensin system in cardiovascular disease 367 4087 4088 PMC7098997__F3 Changes in proteins involved in carbon metabolism and oxidative stress metabolic pathway 847 4118 1738 PMC7101072__F1 Research Priorities for Heart Failure with Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary 4878 4879 260431 100187761 PMC7102936__F3 mTOR at the nexus of nutrition, growth, ageing and disease 1956 5163 2885 5728 7124 2932 201163 57600 652968 83667 6009 153129 PMC7102936__F5 mTOR at the nexus of nutrition, growth, ageing and disease 627 4763 5728 6009 5091 PMC7104260__F1 Internal cues and the mating-pheromone-response pathway converge on the activation of Cdc42 84188 84839 998 5426 PMC7122036__F1 Transforming growth factor B (TGFB) signaling in aortic aneurysms and dissections (AAD) 7939 4087 4088 4089 PMC7122831__F2 Terpene biosynthetic pathway in rose-scented geranium 4200 340451 4598 3652 4597 PMC7125293__F4 Transcriptome analysis on fructose as the sole carbon source enhancing perylenequinones production of endophytic fungus Shiraia sp. Slf14 100 1737 1690 7086 5226 PMC7129598__F1 General overview of disease progression 355 2638 7124 3553 6868 PMC7133220__F9 Putative mechanisms by which neratinib down-regulates mutant K-RAS expression and inactivates Hippo Pathway function 55054 9113 26524 472 PMC7139751__F1 Akt signaling pathway 5728 5266 253260 2475 64223 5163 64798 7249 7248 572 51256 6009 PMC7140419__F4 Main signaling pathways playing role in autophagy activation 5163 23411 7249 7248 9776 60673 2475 PMC7140895__F5 Expression of genes in biosynthesis pathway of catechins, theanine, and caffeine under N, P, and K starvation 2152 2184 64853 PMC7143141__F1 Long-term recreational football training in successful aging 7249 9140 10135 2475 7019 PMC7143722__F3 De-novo fatty acid synthesis in oleaginous microorganisms (adapted from [,,,,,]), and enzymes involved in lipid accumulation 9415 4018 355 95 5741 PMC7155771__F2 The amino acid modulator arm of the mammalian target of rapamycin (mTOR) pathway 5163 7248 51256 7249 2475 6009 153129 PMC7158350__F9 Roles of DEAD/DEAH box helicases in innate immune signaling pathways 55601 57062 1660 56919 1665 7098 170506 54106 9188 57506 51428 6737 695 8772 3665 3661 9879 4615 PMC7161552__F10 Modeling Neoadjuvant chemotherapy resistance in vitro increased NRP‐1 and HER2 expression and converted MCF7 breast cancer subtype 1956 8829 5728 9759 891 PMC7162985__F1 AKT-mTOR signaling pathway 5163 64798 7248 7249 6009 PMC7163125__F10 LXA4, a potential therapeutic agent against KSHV 2475 196 6446 2735 405 PMC7175141__F1 Association between IDH1/2 mutation and NAD Production in Cancer 93100 65220 1719 10135 PMC7175142__F4 Influence of lipid mediators on ER stress-dependent pathway.Disorders in synthesis or action of exogenous factors, like lipid mediators (black) may lead to the generation and accumulation of abnormal proteins (AP) 22926 7494 596 637 PMC7175771__F1 Autophagy pathway 2475 64798 8408 9776 60673 9140 10533 83734 9474 55054 64422 PMC7181071__F1 Main pathway for autophagy modulation 8408 60673 9776 10533 23192 83734 9140 64422 9474 7942 7405 PMC7189756__F8 Downstream signaling events associated with type I interferon actions in nociceptors 3716 6772 1977 6774 PMC7191165__F2 Classic UPR signaling pathways 7186 83939 468 PMC7194552__F4 Phosphatase and tensin homolog (PTEN), a p21-activated kinase (PAK)1 blocker, interferes with coronavirus-induced PAK1-dependent signaling pathway leading to lung fibrosis 5728 59272 6347 5058 PMC7203913__F9 Arabidopsis Plastidial Glucose-6-Phosphate Transporter GPT1 is Dually Targeted to Peroxisomes via the Endoplasmic Reticulum 2937 5829 65220 2539 5226 6120 PMC7207169__F2 MYC and the unfolded protein response in cancer: synthetic lethal partners in crime? 83939 468 10397 PMC7216265__F2 miRNAs affect glutaminolysis in cancer 2744 4149 100302114 9776 50 4204 PMC7226765__F9 Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum 22926 1998 468 7494 PMC7237121__F1 CDK4/6 inhibitors and possible combined therapy with CDK4/6 inhibitors 2475 1021 1019 PMC7237193__F7 Regulatory network of let-7 is associated with the metabolism of glucose, fatty acids and amino acids in the silk gland 7054 2821 1356 5091 3033 1891 PMC7239885__F3 Calcium signalling pathway enriched by 48 downregulated genes encoding 23 proteins marked by stars 90550 5350 1356 857 858 859 3270 10345 613 PMC7244267__F4 Significantly enhancing production of trans-4-hydroxy-l-proline by integrated system engineering in Escherichia coli 11113 4118 100653366 PMC7247521__F6 Component-target-pathway-disease network 1152 2593 4547 548596 5915 1158 5241 1813 5732 336 1160 5914 8435 100187761 4199 3596 5467 7124 26136 7421 6257 9415 57589 5284 5447 5972 4692 1674 1269 PMC7249037__F5 KEGG pathway for ovarian cancer 64374 7054 4609 27040 4311 6095 472 1431 PMC7254712__F4 Graph of the ECM–receptor interaction pathway (17) 7448 960 7450 255743 1101 948 PMC7260123__F9 BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer 3479 8660 2885 2475 9817 PMC7260346__F5 De novo transcriptome analysis unravels tissue-specific expression of candidate genes involved in major secondary metabolite biosynthetic pathways of Plumbago zeylanica: implication for pharmacological potential 9118 83548 4099 PMC7261339__F1 RhoA/ROCK signalling pathway in PH pathogenesis 387 5728 4086 1017 1019 PMC7264673__F1 Does High Cardiorespiratory Fitness Confer Some Protection Against Proinflammatory Responses After Infection by SARS‐CoV‐2? 3654 51135 4615 7189 23118 257397 1636 3553 PMC7264916__F1 Mutations and signaling pathways in vascular anomalies 2050 11235 5921 5604 5159 5290 2475 2022 4090 4086 27302 5728 PMC7265486__F1 Stratification and prediction of drug synergy based on target functional similarity 1956 207 208 91653 PMC7268348__F7 MYC and HIF-1 regulate glucose metabolism 2821 4609 2597 3939 PMC7268632__F3 Novel Outputs of the Unfolded Protein Response (UPR) Related to Learning and Memory Processes 627 7494 468 83939 22926 PMC7269988__F2 ER stress and the activation of the three UPR pathways 22926 7186 7494 83939 468 PMC7272051__F3 Unveiling functional motions based on point mutations in biased signaling systems: A normal mode study on nerve growth factor bound to TrkA 1380 3667 10818 2885 572 PMC7272533__F1 IL-18 signaling pathway 3606 355 5447 5728 1147 572 3932 5578 581 54205 3725 2353 5966 467 1674 5970 8772 49 7913 545 9865 35 847 4666 5763 4232 759 PMC7276919__F4 RNA helicases, the proteins sensing dsDNA and the cross talk between dsDNA and dsRNA sensingDHX9 binds to CpG-B DNA through its DUF1605 domain and leads to NFKB pathway activation and proinflammatory cytokine release 51428 115004 1660 170506 7189 3665 57506 29110 3661 PMC7283470__F1 Emerging role of PTEN loss in evasion of the immune response to tumours 2919 5163 2475 5728 1105 3661 PMC7286536__F1 Insulin regulates glycolysis through both AKT-dependent and AKT-independent mechanisms 5728 572 10628 3099 2597 PMC7287096__F5 Schematics of trafficking deficits mediated by pathogenic LRRK2 or knockdown of Rab8a 120892 4218 1956 PMC7299241__F3 Actions of IGF-1 in the Growth Plate and its Role in Postnatal Bone Elongation 3479 2932 2475 572 PMC7338473__F1 Insulin receptor endocytosis in the pathophysiology of insulin resistance 1443 2549 991 PMC7348083__F2 Heat shock protein 90 inhibition and multi‐target approach to maximize cardioprotection in ischaemic injury 11140 9817 3297 PMC7350257__F3 PI3K-AKT-mTOR and AR signaling crosstalk facilitates resistance to androgen/AR and AKT-directed monotherapy 1586 367 2289 354 8501 PMC7352181__F1 Renin-angiotensin system, its interaction with tumor hypoxia and angiogenesis and subsequent functional impact on tumor phenotype 59272 1636 1509 PMC7352181__F3 Angiotensin-associated pathways involved on hypoxia and angiogenesis in lung tumor microenvironment 7039 1950 1636 59272 2475 PMC7355786__F3 Mechanism of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway 5163 5728 7249 7248 6009 PMC7358455__F9 Schematic illustration showing the mechanism of melatonin(Mel)sensitises shikonin(SHK)-induced cancer cell death 4199 23410 6648 PMC7359322__F6 Heat map and DEGs expression profiles of genes associated with phenylpropanoid biosynthetic pathway, (B) heat map showing the different expression profiles of genes involved in the terpene biosynthesis pathway 4598 9961 1312 4200 340451 790 4597 3652 PMC7366106__F8 TNF pathway modified from hsa04668 7124 8772 717 836 83737 3569 3976 7186 8717 4314 6401 197259 7187 PMC7367654__F7 Triptolide-induced apoptosis in non-small cell lung cancer via a novel miR204-5p/Caveolin-1/Akt-mediated pathway 23411 857 23410 PMC7374090__F5 Development and implementation of the SUM breast cancer cell line functional genomics knowledge base 10207 154796 23513 166824 332 174 4092 4089 1499 324 PMC7378646__F3 Crosstalk between the Hippo-YAP1/TAZ pathway and BMP signaling 4090 4086 4485 4089 9113 26524 10413 PMC7381294__F7 Differentially methylated genes enriched in the AMPK signaling pathway 9370 3953 6774 355 5183 PMC7388972__F5 Schematic representation of S. pombe cell wall integrity pathway 5106 5105 466 PMC7390965__F1 Differences between the UPR in mammalian and plant cells 22926 7494 83939 PMC7392886__F2 Development of immunothrombosis.Platelets activated by thrombin and or PICs initiate (PAR)–mediated signalling further increasing levels of PICs VWF and TF coupled with suppression of suppression of thrombomodulin 7018 7035 5340 7448 PMC7393602__F1 Nav1.5 promotes the activity of NHE-1, resulting in the acidification of the peri-membrane, which favors the proteolytic activity of Cat and MMPs (yellow line) 960 5879 6615 PMC7395702__F1 Signal Transduction Pathway of PD-1 / PD-L1 2885 27040 2475 PMC7396059__F3 NKG2D signaling pathways 2885 1399 7409 5879 PMC7397409__F1 ERS and unfolded protein response (UPR) 22926 468 100187907 PMC7402354__F2 Platelet signaling pathways that trigger ROS production 9618 4067 6850 6714 948 4512 PMC7405053__F1 An overview of PG biosynthesis, receptors, and downstream signalling pathways 4512 231 27306 PMC7409344__F2 eIF3 consists of the conserved eIF3a, eIF3b, eiF3c and the less conserved eIF3e, eIF3f, eIF3h subunits 8662 8665 8661 3646 8663 8667 2475 PMC7409348__F5 Graphic representation of signaling pathways that promote gastric cancer 5163 5728 627 PMC7409924__F1 Methylene blue may have a role in the treatment of COVID-19 5340 1636 4513 PMC7410499__F1 Functionally annotated network of genes involved in the hypertension-hypotension axis whose expression across the GTEx population is correlated and anticorrelated with the AGTR1 and AGTR2 receptors 100187761 4099 5476 1636 PMC7415776__F1 Metabolic rewiring of cyanobacterial central metabolism with a synthetic acetate‐acetyl‐CoA/malonyl‐CoA (AAM) bypass for improved photosynthetic production of acetone from CO2 2695 4118 64853 PMC7418153__F2 An overview of non-canonical Wnt signaling pathway 6259 5754 23002 5879 387 998 PMC7418812__F9 Model for glucose regulation ovarian primordial follicles activation via the AMPK/mTOR signaling pathway 4485 2475 9113 PMC7429631__F1 Profilin interactions in the membrane 5728 2475 1950 PMC7431799__F10 Model showing how PRRSV utilizes viral apoptotic mimicry and TIM-induced macropinocytosis as an alternative pathway to infect host cells 5058 5879 998 9332 PMC7432891__F1 Schema of the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway and its regulators and effectors 2885 596 351 3725 10682 2353 6667 PMC7436103__F7 lncRNA target pathway network in AGPS-silenced U251 cells 8190 465 100187761 PMC7445477__F7 Troxerutin on vascular inflammatory mediators and expression of microRNA-146a/NFKB signaling pathway in aorta of healthy and diabetic rats 3654 7189 3383 3553 3569 PMC7448569__F5 Gene expression profiles of the C-type lectin receptor signaling pathway in the breast cancer group 5971 3569 3558 3589 2444 59067 6773 1540 4863 6418 PMC7450308__F1 Increasing ROS triggers mitochondrial damage related to ferroptosis under cysteine starvation 7018 2643 2879 637 PMC7459008__F1 PI3K-Akt pathway mediated antiviral mechanism in silkworm Antheraea mylitta 3667 6446 5163 5164 2885 6461 2475 PMC7460696__F1 Lysophosphatidate (LPA) signaling pathway 4018 4099 6010 PMC7462335__F5 Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine 2247 1950 1956 351 2475 7040 5728 2932 3611 23237 581 6774 3091 595 7015 PMC7462725__F2 Pathophysiological processes that drive cyst formation and growth in renal tubular epithelial cells of the collecting duct in ADPKD and the mechanism of action of vasopressin V2 receptor antagonists and SST analogues 1080 7248 7249 2475 PMC7463463__F2 Targetable vulnerabilities related to serine and 1C metabolism 4144 26227 1719 6472 6470 1723 2618 PMC7464074__F1 HER2 signaling pathway, mechanism of action of targeted therapies, and resistance mechanisms 3480 5728 2475 PMC7471650__F1 Signaling pathways underlying Sirt3-mediated regulation of autophagy 6648 23410 2475 PMC7483331__F2 Protein signaling networks regulating autophagy 9140 60673 5163 967 6774 6714 PMC7485269__F2 (m)TOR pathways and downstream factors and processes in fly and mammals 5163 3667 5728 1975 27250 1977 51256 7249 6009 8408 7942 1997 10209 1998 2001 1983 1999 PMC7490904__F1 Physiological functions and regulation of the cyclin D-CDK4/6 complex 1021 1019 7249 1017 PMC7492613__F3 JAK-STAT modulating genes in PMN-MDSCs in the circulation of CRC patients 324 3952 2688 51094 6775 4609 598 5771 8027 10379 2670 2475 PMC7502313__F1 Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review 22926 7186 7494 83939 468 596 100187761 PMC7503879__F6 Insulin/FoxO signaling pathway in silkworm diapause eggs at onset of diapause 3630 3479 5163 5164 PMC7504001__F10 Schematic picture proposing that OXY modulates the IL-1Beta-stimulated inflammatory response 3654 51135 7189 PMC7509487__F2 How a miRNA affects cellular function: Left, repression of one critical mRNA by an individual miRNA determines cell function 8651 1847 26191 1848 5728 PMC7520283__F2 DNA methylation and histone acetylation involved in OA‐FLS inflammation 3553 3717 3667 7189 6774 1958 3383 7412 PMC7531435__F1 Key Figure 6010 55605 7054 PMC7533008__F4 Underlying glucometabolic mechanisms on pyruvate protection against diabetic nephropathy 367 2539 4509 PMC7536068__F1 Schematic depicting an overview of the autophagy pathway and mechanisms used to manipulate autophagy 100188784 10533 64422 9474 9140 PMC7539315__F5 Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B 8027 2670 2937 10162 7018 55240 1356 5094 8031 PMC7542964__F4 KEGG enrichment map of NOD-like receptor signaling pathway 1611 331 5066 90550 4609 387 PMC7551039__F1 Immune checkpoint-mediated T-cell inactivation 324 7535 1493 940 201633 920 3902 151888 PMC7552962__F1 Proposed model of interactions between ion channels and Wnt signaling 3784 1080 324 7224 54795 59341 PMC7554708__F3 Representative pathways involved in the metabolism of diacylglycerol (DAG) and phosphatidic acid (PA) 5091 4018 4026 PMC7563239__F1 Possible mode of action of matrikines on pulmonary arterial endothelial cells 355 2475 387 1003 8772 PMC7565554__F1 TORC1 and TORC2 subunits and processes controlled by the complexes 64798 2475 64223 55615 253260 PMC7569467__F1 Schematic graph demonstrates the role of glial cells and the relevant signaling pathway 4852 7099 114548 8564 3603 3586 PMC7576986__F2 Type I IFN signaling and viral countermeasures 7297 3716 6773 6772 10379 PMC7577940__F1 Mechanosensation 4485 60485 9113 6714 PMC7583982__F2 Functions of miRNAs in EOC metastasis 693201 100126333 102465134 999 1000 2475 574493 100126326 693137 PMC7585656__F1 Reactive oxygen species- (ROS-) mediated inhibition of glycolysis reroutes flux into the oxidative arm of the pentose phosphate pathway 5226 2539 2936 2597 PMC7585866__F1 Diagram of regulatory mechanism of renin-angiotensin system (RAS) 183 59272 1636 PMC7589016__F2 Intracellular signaling cascades activated by interaction of BDNF isoforms with its receptors 7189 387 5163 5728 PMC7593950__F5 Simplified scheme of putative role, function, and involvement of VEGF, PlGF, and IGFBP-3 in signaling pathways described in angiogenesis and tumor growth 5281 3486 998 5335 2475 PMC7594717__F8 Metabolic flux map for C 100187761 11113 4118 PMC7598160__F3 Glycolysis and oxidative phosphorylation in the retina 2864 7436 95 1376 PMC7603577__F11 AGE-RAGE signaling pathway in diabetic complications in the treatment of gout and hyperuricemia with plantain 3383 3569 581 PMC7642714__F8 C-type lectin receptor signaling pathway 5971 6850 7054 868 387 4046 602 1540 10129 PMC7647673__F1 Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics 8635 60528 4553 PMC7652990__F2 Network of pathways involved in respiration, ethylene biosynthesis, and signaling, and ROS production and signaling during the ripening process 2717 4609 4548 PMC7655627__F1 The mTOR pathway in liver cancer: from molecular genetics to targeted therapies 5728 64798 5163 6009 7249 7248 10797 790 PMC7666199__F4 Reconstructed hydrogenotrophic methanogenesis metabolic pathway with associated carbon fixation through the reductive Acetyl-CoA pathway, methane metabolism and coenzyme biosynthesis by Methanobacterium sp 266710 5447 4548 PMC7673069__F1 Schematic presentation of the life cycle of SARS-CoV-2 in the host cell and proposed sites of famotidine action 59272 7113 5478 PMC7685642__F2 miRNAsis involved in up-regulation of the bladder cancer 5728 407009 64798 PMC7686079__F4 APC mediates biased signaling of PAR1 387 324 5879 5091 PMC7690430__F3 Targeting the PI3K–AKT–mTOR pathway to treat prostate cancer 5728 5163 7248 7249 PMC7692384__F10 Neurofibromin regulation of the growth factor-controlled Ras/PI3K signaling pathway 2885 5163 4763 7249 6009 2475 PMC7697636__F1 Classical degradative autophagy (macroautophagy) 10533 6009 64422 83734 55054 9140 9474 PMC7699596__F3 Key autophagy pathway and its regulators (natural compounds) for treating diverse cancers 5894 7249 7248 2475 8408 PMC7699713__F1 Redox Potential of Antioxidants in Cancer Progression and Prevention 2885 847 85451 6303 PMC7701056__F1 PI3K/Akt/mTOR pathway 5728 5163 5164 64798 6009 7248 7249 PMC7709275__F1 Role of the unfolded protein response (UPR) in cancer 468 83939 22926 PMC7716236__F3 Metabolic variations in the course of NB4 differentiation along the myeloid lineage after treatment with ATRA 1506 3945 230 2597 5223 4712 6389 226 3939 1611 PMC7721156__F2 Interaction of preimplantation factor with the global bovine endometrial transcriptome 7124 8772 836 26136 7975 4892 197259 PMC7724003__F7 Nucleus accumbens-deep brain stimulation (NAc-DBS) alters neural excitability by modulating neuronal signaling pathways 5972 26136 2548 PMC7724953__F1 MTOR pathway 7124 1950 1956 3667 2549 5728 5163 7249 7248 6009 PMC7725927__F1 mTORC1 signaling pathway 2885 7249 7248 6009 1999 PMC7728580__F2 Role of H2S in HCC 875 1956 6774 2475 PMC7729224__F2 Cyclic adenosine monophosphate (cAMP)-cAMP response element binding (CREB)-miR-21- programmed cell death protein 4 (PDCD4) axis 5728 27250 2475 PMC7729224__F3 Wnt/Beta-catenin-c-Myc-miR-17∼92 axis 1499 2475 5465 PMC7734100__F2 How coronavirus disrupts signaling pathways (autophagy, ER stress, cytokine storm, and hypoxia) and induces cell death 22926 8408 9776 83939 7494 6502 468 5355 PMC7746877__F1 Signaling pathway of EMT 6010 1499 324 PMC7751468__F6 Differentially expressed genes between normal mammary tissues and triple negative breast cancer tissues involved in PI3K/Akt signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes analysis 5879 613 6850 5266 5728 4099 572 4199 4602 4193 PMC7756641__F4 Adaptogens on adaptive stress response intracellular signaling pathways (updated from authors’ drawings) 929 5163 2353 PMC7756807__F2 Energy‐generating regulators in Tregs 940 5728 3091 7248 50943 4609 PMC7763629__F2 RTKs (EGFR) signal transduction and are a target site for small molecule and monoclonal antibody in glioma treatment 1956 2475 5728 5163 PMC7768255__F3 Starvation Responses Throughout the Caenorhabditis elegans Life Cycle 238 2549 5728 5163 208 207 PMC7768823__F1 Actionable nodes of the autophagy pathway 8408 9706 9776 60673 55626 9474 9140 10533 64422 83734 PMC7771963__F1 Interconversion of phosphoinositides in eukaryotic cells 4952 5728 56623 5266 9896 PMC7780193__F1 Cell Energy Metabolism and Hyaluronan Synthesis 101448070 2821 7358 8473 10724 PMC7783402__F2 Role of IIS signaling pathway in reproduction and its longevity Schematic diagram elicits that IIS is actively involved in reproductive function and lifespan in C 5728 2885 5170 PMC7783759__F7 Cezanne deubiquitinated IGF-1R and regulated IGF-1R signaling pathways 3479 3667 3480 2002 1386 PMC7784492__F3 Pathways affected by mutations 2264 4763 5728 6774 1017 1019 PMC7785019__F4 Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog 7971 3652 95 100653365 8775 4841 PMC7785817__F2 Structures of Slit/Robo, and the Slit-Robo signaling pathway 122769 1000 57522 1499 998 387 PMC7789510__F6 Simplified schema and functions of SAUR genes in plant evolution 382 560 4149 7054 PMC7790891__F2 Regulatory network of ginsenosides in macrophage 5925 2475 1401 PMC7792222__F4 miRNA-mediated regulation of BCSCs via targeting the PI3K/AKT/mTOR signaling pathway 5728 5163 2475 PMC7794785__F5 Activation of MAPK pathways (highlighted in yellow), the guanyl cyclase pathway (highlighted in orange) and nuclear factorKB (highlighted in purple) by the adenosine A1 receptor (A1R) 367 2885 57580 PMC7795259__F1 Fibrosis related intracellular Ca2+signaling pathways 759 5091 2475 PMC7800773__F1 Combination therapies for MPNSTs targeting RABL6A-RB1 signaling 1017 1021 1019 5925 PMC7821926__F1 Unfolded protein response (UPR) pathway 260431 22926 83939 7494 468 596 PMC7824196__F1 Different steps of autophagy 9140 9474 10533 64422 2475 100170220 4077 60673 9776 8408 PMC7826519__F3 Lipid synthetic pathway 64798 2475 64223 22937 2194 PMC7827439__F3 Cytokine-mediated immune–epithelial crosstalk in inflammatory bowel diseases 90865 7124 7054 324 5008 PMC7827772__F3 Calreticulin (CRT) exposure in the response to immunogenic cell death (ICD) inducers 22926 581 8773 PMC7836022__F1 Metabolic pathways and signaling in cancer 4118 4609 11113 PMC7839966__F5 Comprehensive analysis of the lncRNA-associated competing triplets 125144 441951 60674 PMC7840718__F1 Cancer cells ingesting extracellular small particles, such as protein, necrotic debris, and ATP, through macropinocytosis 1956 5058 5728 998 5879 2475 PMC7841880__F1 Canonical PTEN pathway depicting PI3K/AKT/mTOR and MAPK/ERK signaling 5728 2475 253260 5163 5266 83939 PMC7841926__F4 Illustration of the calcium signaling pathway induced by major putative targets of SMT 858 859 5350 PMC7846970__F3 ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease 4142 387 9475 56954 PMC7859757__F4 ER stress can be triggered by alcohol, bile acids, pancreatic toxins, and increased protein synthesis 7494 22926 83939 468 PMC7864737__F4 Target genes in the mTOR signaling pathway 2475 201163 6009 1977 64798 5728 PMC7865768__F4 Domain structure of SPAK and the phosphorylation target sites on NKCC1 and KCC3 65267 907 130497 PMC7869004__F6 Drug target prediction and repurposing“Waterdrop” diagrams showing drug-target 26136 2744 6616 54704 2475 PMC7876332__F7 Scheme about the central role of erianin in ferroptosis induction and migration inhibition 2475 581 1019 1017 PMC7876795__F3 Alternative signaling activation induced FGFR-TKI resistance 1956 5728 2065 2049 2475 10818 1848 PMC7878563__F6 Signaling pathways coupled to the M4 mAChR 156 10399 2932 PMC7878609__F3 Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling 7852 1956 1950 6387 5163 PMC7879595__F1 The TME of solid tumors has the common characteristic of hypoxia (1% O2), which is due to a low supply of nutrients and oxygen 84890 581 596 PMC7880553__F2 Figure 2.Metabolites in early adulthood are associated with the cardiovascular phenome and identify pathways central to CVD development 5091 718 1431 727 PMC7881277__F3 Apoptosis signaling pathway and the predicted gene targets of miR-410 (IL1R, XIAP, NTRK1, PPP3CA, PRKACB3) and miR-19a (IL1R1, PIK3R3, MAP3K14, PRKACB3), which are involved in cytokine–cytokine receptor interaction 331 355 8717 8772 637 2021 4615 572 472 581 PMC7886700__F1 Growth factor mediated activation of AKT1 207 5163 2932 PMC7887252__F8 Proteins/enzymes in this pathway regulate both calcification and atherosclerosis 953 5167 348 PMC7904555__F2 Intracellular trafficking pathways of TLR4 and TRAM 7099 382 9535 1130 26276 PMC7904579__F7 Applying Genome-wide CRISPR to Identify Known and Novel Genes and Pathways that Modulate Formaldehyde Toxicity 64121 10670 2475 55004 28956 8649 6520 4041 2932 83667 7249 7248 201163 6009 6502 220441 64798 9675 1977 1975 PMC7904626__F1 Biosynthetic pathway of oxetanocin-A (1) 867 2242 6420 PMC7905684__F1 Novel targeted therapies for Parkinson’s disease 2668 120892 2821 4827 2740 6476 4478 PMC7906326__F3 Current understanding of the interplays between host hormones and plant viral infections 1356 26523 221833 PMC7906381__F2 Pathway enrichment analysis of (a) DE-miRNAs and (b) DCGs 2475 3815 5898 PMC7910064__F5 Schematic figures of metabolic alterations in HCC 7038 355 3417 948 5465 2539 3030 PMC7910587__F6 Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry 1956 6714 7410 5879 998 8826 29127 PMC7910854__F8 Schematics of neural circuit involved in phototaxis behavior 8989 5640 64146 PMC7910861__F1 Evasion of RLR-mediated innate immunity through viral manipulation of ubiquitination and ISGylation 1283 9636 389856 1540 9958 7706 57506 29110 3665 3661 PMC7912673__F1 Panel (A): Mechanisms of drug inhibition on cellular pathways 5728 7249 7248 6009 PMC7912811__F1 Gonadotropin releasing hormone (GnRH) receptor signal transduction in endometrial cancer (EC) 8205 1950 1956 6714 2885 3727 6722 2353 PMC7912927__F1 PI3-K/Akt/mTOR signaling cascade 5728 7249 7248 6009 2475 253260 5163 3611 PMC7920857__F8 Mechanism graph of the regulatory network and function of SIRT1 in aging of HEMECsSIRT1 restrains cell aging through GIRDIN phosphorylation via Akt signaling pathway 3479 23411 5163 PMC7921306__F1 Genomic and non-genomic mechanisms of glucocorticoids 7124 3569 3586 PMC7921686__F8 Integrated pathways map of fucosterol in the treatment of NSCLC include (A) the non-small cell lung cancer pathway, marked in yellow as the functional targets of fucosterol, and (B) the key signal transduction pathways 2272 572 1610 842 PMC7921839__F2 Diagram depicting the main proposed events in the autophagy pathway 22863 9776 83734 545 9474 PMC7923165__F3 Actin cytoskeleton regulation pathway is enriched in SYK targets in the MCF7 and MDA231 breast cancer cell lines 3630 2147 1793 324 6010 5829 7414 2934 PMC7925099__F15 The action of PAV-206, a possible first-in-class selective inhibitor of HIV-1 assembly 10146 54464 1656 PMC7925768__F1 O-GlcNAcylation: the “stress and nutrition receptor” in cell stress response 7175 10724 914 PMC7926472__F1 A general map of core metabolism 4553 2242 717 PMC7927447__F2 Action of targeted therapies in PIRDs 324 5728 140892 114034 PMC7929421__F2 Unfolded protein response pathway 22926 378938 7186 83939 7494 468 596 PMC7930745__F2 TMEM16A regulates EMT and cancer cell migration and metastasis 2885 6774 1956 PMC7937672__F1 Cutting the molecular brakes to achieve cardiac regeneration 3611 4041 4040 1499 9771 3091 7008 PMC7941261__F5 Skeletogenic cell gene regulatory network (GRN) 7008 2113 8092 3344 2078 PMC7943547__F1 Role model of intracellular HYOU1 in tumor development 10525 83939 468 22926 PMC7943556__F1 Signaling by the phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway 1956 3480 5163 5728 PMC7944035__F1 TLRs multiple signaling pathways 3479 114548 3661 7099 4087 4086 6774 100133941 4615 PMC7946832__F1 Complement cascade and key canonical and non-canonical activities 717 2475 4179 727 PMC7947908__F5 Insights Into the Involvement of Circular RNAs in Autoimmune Diseases 324 718 920 1386 PMC7948403__F5 Ferroptosis in Alzheimer's disease 23621 2879 5212 PMC7952751__F4 Interplay between autophagy and apoptosis, and the regulation of autophagy and apoptosis by foot-and-mouth disease virus (FMDV) infection 22863 10533 83939 468 8717 PMC7956893__F2 Anticancer molecular mechanisms of PPs 83939 2475 468 PMC7962413__F2 Tick signaling-related genes in the three main immune signaling pathways of arthropods: (A) Toll, (B) IMD, and (C) JAK/STAT 331 8772 54472 23118 8027 51295 58509 PMC7971348__F2 Ubiquitin-proteasome pathway influences proteostasis, the cell cycle, and filamentation 324 999 991 3491 6500 PMC7981903__F3 Role of GRP78 in cellular apoptosis 7186 83939 468 PMC7982634__F3 Natural extracts exert inhibitory effects on PI3 K/Akt signaling pathway 5163 5728 572 842 4193 2932 6194 2626 PMC7986631__F1 Cannabinoid biosynthesis including polyketide and isoprenoid precursor pathways 95 3652 3009 PMC7992277__F10 Na+ controls hypoxic signalling by the mitochondrial respiratory chain 90550 790 4666 759 PMC7996755__F2 Targeting Nrf2 signaling pathway in chemoprotection 5004 847 9817 PMC7998316__F3 Simplified scheme highlighting processes in which PD-related proteins function in the endo-lysosomal pathway 8398 51699 55737 PMC7998903__F5 Involvements of the studied neurotransmitters in tumor development 146 1813 23108 1958 2475 PMC7998928__F1 Detrimental role of Formyl Peptide Receptor 1 (FPR1) in CVDs progression 3553 3569 2357 PMC8001593__F3 Host-catalyzed HIV-1 assembly pathway was developed into a screen for small molecule inhibitors 1656 10146 54464 PMC8003462__F1 Physiological functions of the various kinases included in the PKR/p38/RIPK1 pathway 8737 83939 23621 PMC8005112__F2 Mechanisms of synergy between small molecules and immune checkpoint inhibition in melanoma 673 5163 8205 324 PMC8005514__F1 PI3K/AKT signaling pathway in breast cancer 5728 5163 572 PMC8012837__F1 Trop2 signaling 10399 1499 8650 142 PMC8013721__F1 Summary of radiation-induced oral mucositis pathogenesis 4312 3553 4314 PMC8013731__F8 Toll-like receptor signaling pathway and NF-kappa B signaling pathway regulated by the S100s alteration in HCC 7097 5879 7124 54472 8772 3929 929 8178 23118 958 51135 130749 1513 7098 6955 100187907 PMC8016949__F1 Assessing fatty acid-induced lipotoxicity and its therapeutic potential in glioblastoma using stimulated Raman microscopy 355 8694 84649 PMC8020867__F1 Map of net odds () for reactions of glycolysis and the tricarboxylic acid (TCA) cycle 5183 6120 57120 PMC8020906__F2 mTOR is activated by growth factors via PI3K-Akt and RAS/MAPK pathways 5728 5163 6009 PMC8020906__F3 mTOR in cancer stem cells (CSCs) 6657 2735 1499 PMC8035080__F4 Mycolic acid biosynthesis and recycling 4322 1690 3623 PMC8036867__F2 Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1A) in the onset of Parkinson’s disease 65018 2876 6648 7019 PMC8042594__F1 Monocytic and macrophage contribution to SARS-CoV-2 hyperinflammation 3553 59272 3716 9021 6774 PMC8046533__F3 KEGG Pathway analysis of IFNg protein in tuberculosis disease 8567 842 9118 3565 4609 929 PMC8047446__EV5 GOLPH3‐driven functional enzyme module 64083 5163 1506 PMC8048291__F9 Schematic depiction of endolysosomal pathway dysregulation in Huntington’s disease 967 3916 3064 PMC8059748__F1 PI3 kinase signaling pathway 5728 7249 7248 6009 572 2475 PMC8064375__F4 Persulfidated proteins identified in root tissues involved in autophagy 9776 9140 83734 10533 64422 PMC8067185__F1 Induction of EMT by targeting EMT-related genes via activation of the growth factor signaling pathway in pancreatic cancer 3065 3066 1000 999 6275 4488 PMC8072021__F3 Cellular Prion Protein—ROCK Connection: Contribution to Neuronal Homeostasis and Neurodegenerative Diseases 387 5163 351 857 8178 PMC8076600__F4 Cytoskeleton Dynamics in Peripheral T Cell Lymphomas: An Intricate Network Sustaining Lymphomagenesis 387 238 7409 10451 5879 998 6790 10013 3070 58480 29851 2475 5347 PMC8080614__F5 Glutamine oncometabolites and energy production from glutamine 2271 3418 9817 3417 4190 7038 4191 2806 2805 PMC8082066__F7 SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease 23411 54790 1029 1019 PMC8083963__F2 Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease 55737 2147 2152 51699 PMC8088836__F4 PH Regulation in the Tumor Microenvironment (TME) 197257 2305 2539 5163 2475 3091 7428 PMC8093429__F1 Cellular Responses to the Efferocytosis of Apoptotic Cells 64284 9474 10533 PMC8097443__F7 Ethylzingerone, a Novel Compound with Antifungal Activity 6886 2023 2026 2020 PMC8100412__F9 Integrated Molecular Docking with Network Pharmacology to Reveal the Molecular Mechanism of Simiao Powder in the Treatment of Acute Gouty Arthritis 8717 6887 6955 7536 4094 7054 6476 PMC8102094__F3 Positive and Negative Regulation of Ferroptosis and Its Role in Maintaining Metabolic and Redox Homeostasis 472 23657 27165 PMC8103215__F4 Beta-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NFKB Signal Pathway: In Silico and In Vivo 1611 100187761 90550 1208 10129 PMC8103676__F7 Persistent Giant Algal Virus, with a Unique Morphology, Encodes an Unprecedented Number of Genes Involved in Energy Metabolism 6389 2242 6392 6390 6391 95 PMC8103695__F5 Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo 64798 7249 7248 6009 2932 3667 PMC8106186__F1 Signalling pathways involved in CM, UM and MM oncogenesis, and regulation of HIF under hypoxia 7852 3815 4893 4763 5728 673 2475 PMC8106603__F2 Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma 7494 83939 9927 55669 PMC8110445__F9 拟康氏木霉胞外多糖联合奥沙利铂可体外协同抑制结直肠癌细胞的增殖 55750 6850 930 5728 572 4602 2157 1277 PMC8112354__F1 O-GlcNAcylation in Immune Cell Activation 3663 7189 10724 PMC8113420__F1 Possible mechanistic links between the activation of the PKR-eIF2A branch of the ISR and hippocampal/cortical plasticity under physiological and age-related neurodegenerative conditions 30062 83939 468 PMC8117390__F1 Polymorphisms in MicroRNA Target Sites of TGFB Signaling Pathway Genes and Susceptibility to Allergic Rhinitis 7046 658 718 PMC8122946__F6 Gene Coexpression Network Analysis Indicates that Hub Genes Related to Photosynthesis and Starch Synthesis Modulate Salt Stress Tolerance in Ulmus pumila 6955 2695 8139 PMC8124548__F3 Inhibitors of Chemoresistance Pathways in Combination with Ara-C to Overcome Multidrug Resistance in AML. A Mini Review 150365 2475 581 572 PMC8125679__F2 More Than Meets the Eye: Scientific Rationale behind Molecular Imaging and Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA) in Metastatic Prostate Cancer and Beyond 2316 83595 367 10399 3480 PMC8130408__F1 Nicotinamide adenine dinucleotide (NAD+) biosynthetic pathway mediated by nicotinamide phosphoribosyltransferase (NAMPT) and circadian NAD+ oscillation 952 23411 51548 9575 10135 PMC8135154__F1 Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism 93100 10135 23411 652968 5163 8408 6009 PMC8136750__F2 NAD Metabolism and its biological role in mammalian cells 203447 952 10135 PMC8137523__F2 Oncogenic signaling pathways play a dual role in generating tumor hallmarks that increase demand for mevalonate pathway intermediates while concurrently upregulating mevalonate pathway meet the demand 1499 6010 2885 47 PMC8141582__F7 Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor 1586 2224 3156 2475 7249 7248 22937 PMC8150686__F2 Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer Research 2475 7157 999 PMC8151162__F4 Transcriptome Analysis of the Japanese Pine Sawyer Beetle, Monochamus alternatus, Infected with the Entomopathogenic Fungus Metarhizium anisopliae JEF-197 9437 9436 841 29110 4615 PMC8154354__F2 Insights into Ammonia Adaptation and Methanogenic Precursor Oxidation by Genome-Centric Analysis 2184 4397 275 4548 5447 367 PMC8155122__F3 Biased signaling of oxycodone and morphine 5037 7442 1956 PMC8155903__F5 Differential mRNA and miRNA Profiles Reveal the Potential Roles of Genes and miRNAs Involved in LPS Infection in Chicken Macrophages 3929 7097 10333 929 54472 114609 54106 7098 8772 4609 23118 3661 958 923 PMC8156652__F9 Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles 2885 5728 2932 PMC8165101__F7 Small molecules in targeted cancer therapy: advances, challenges, and future perspectives 472 1111 11200 5888 545 79728 PMC8172474__F1 Therapeutic Escape in GAq-Mutant Uveal Melanoma: It’s a FAK 7204 6010 8314 3902 PMC8172611__F9 Glucocappasalin Induces G2/M-Phase Arrest, Apoptosis, and Autophagy Pathways by Targeting CDK1 and PLK1 in Cervical Carcinoma Cells 983 5347 2475 9474 PMC8183409__F2 Mutations in PTEN and TSC1/2 are associated with dysregulation of translation and transcription 6259 7249 6009 7054 PMC8192743__F12 Mechanistic insights into TNFR1/MADD death domains in Alzheimer’s disease through conformational molecular dynamic analysis 7099 8717 4615 7124 7189 PMC8194146__F7 Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer 693176 574473 4485 442917 6657 PMC8195694__F1 Interferon therapy in patients with SARS, MERS, and COVID-19: A systematic review and meta-analysis of clinical studies 7098 51284 59272 57506 7113 PMC8196972__F6 Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis 6347 947 729230 PMC8197327__F1 Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour 7852 6387 596 581 7189 PMC8200641__F2 Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis 83939 468 7494 22926 PMC8200641__F4 Endoplasmic Reticulum Stress, a Target for Drug Design and Drug Resistance in Parasitosis 83939 4280 11231 PMC8201009__F1 Cancer-Associated Glycosphingolipids as Tumor Markers and Targets for Cancer Immunotherapy 51083 6762 2524 2523 64921 PMC8203325__F2 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges 2885 6009 5728 5163 7249 7248 PMC8203325__F4 Targeting Signaling Pathway Networks in Several Malignant Tumors: Progresses and Challenges 7124 8772 7186 8717 54472 4615 PMC8204019__F3 Radiation Resistance: A Matter of Transcription Factors 7124 472 331 3383 891 595 PMC8217088__F6 Lipid metabolic alterations induced by EPHB2 deficiency in prostate cancer 2048 8694 84649 PMC8217661__F2 Wiskott-Aldrich Syndrome Protein: Roles in Signal Transduction in T Cells 2002 3702 324 1399 PMC8220219__F4 Hippo, TGFB/SMAD, Wnt/Beta-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer 4087 9219 467 PMC8222328__F4 Identification of biological pathway and process regulators using sparse partial least squares and triple-gene mutual interaction 8213 5447 790 PMC8222785__F1 Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas 2475 1956 3417 3418 5728 4255 5411 PMC8224460__F1 Resistance Responses of Potato Plants to Potato Virus Y Are Associated with an Increased Cellular Methionine Content and an Altered SAM:SAH Methylation Index 4524 867 4397 PMC8226607__F1 Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target 952 10135 93100 23475 23098 PMC8226784__F10 Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells 2475 64223 7249 7248 6009 5728 253260 5163 PMC8226934__F1 Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling 5163 2475 5793 10818 2885 2549 2888 7018 PMC8226934__F2 Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling 2261 867 7251 PMC8227265__F1 Enhancing Sesquiterpenoid Production from Methane via Synergy of the Methylerythritol Phosphate Pathway and a Short-Cut Route to 1-Deoxy-D-xylulose 5-Phosphate in Methanotrophic Bacteria 3652 9997 11113 4118 PMC8229605__F1 Molecular Perspective of Nanoparticle Mediated Therapeutic Targeting in Breast Cancer: An Odyssey of Endoplasmic Reticulum Unfolded Protein Response (UPRER) and Beyond 22926 1998 468 PMC8232639__F1 Insulin in Health and Disease: An Update 5163 23216 572 1977 7249 7248 2885 PMC8235525__F2 Metabolic Choreography of Maize Plants Treated with a Humic Substance-Based Biostimulant under Normal and Starved Conditions 55364 718 4118 PMC8235983__F5 Study on the Molecular Mechanism of the Herbal Couple Sparganii Rhizoma-Curcumae Rhizoma in the Treatment of Lung Cancer Based on Network Pharmacology 7124 7913 4609 472 7054 7374 351 339855 PMC8236950__F5 Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients 59272 1636 7113 6774 3717 PMC8236958__F6 Identification of Regulatory Functions of LncRNAs Associated With T. circumcincta Infection in Adult Sheep 6714 59330 6010 51083 960 PMC8238076__F6 Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation 4661 7465 993 545 PMC8247566__F2 MiR-126 pro- and anti-angiogenic function in different cell-types 7412 9294 5296 8788 6120 PMC8248532__F8 Cryptotanshinone Inhibits the Growth of HCT116 Colorectal Cancer Cells Through Endoplasmic Reticulum Stress-Mediated Autophagy 9140 4199 178 PMC8251975__F3 Wnt/B‐catenin signaling: Structure, assembly and endocytosis of the signalosome 8411 7251 5058 998 PMC8257821__F6 PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling 5728 2194 84232 PMC8258161__F1 Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis 1611 4118 2012 51083 3382 4351 58525 PMC8263891__F5 Therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology 355 929 8213 7186 23118 5624 1616 2645 3240 4351 51701 7216 4703 4149 4208 6722 PMC8263891__F6 Therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology 122042 3640 5970 4322 351 PMC8264285__F3 Targeting Tumor-Associated Antigen: A Promising CAR-T Therapeutic Strategy for Glioblastoma Treatment 5879 5058 3082 2885 6667 PMC8264607__F9 Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFB induced collagen synthesis in cardiac fibroblasts 6497 7076 7077 1301 1901 PMC8268101__F2 Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors 5879 998 6774 PMC8268312__F3 Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators 57506 3661 3716 7297 6773 6772 PMC8268527__F1 Targeting NEDDylation as a Novel Approach to Improve the Treatment of Head and Neck Cancer 9039 4738 55832 PMC8269153__F3 NRF2-Related Epigenetic Modifications in Cardiac and Vascular Complications of Diabetes Mellitus 196 9817 55384 PMC8269449__F1 Pharmacogenomics of Hypersensitivity to Non-steroidal Anti-inflammatory Drugs 324 4512 4049 PMC8273767__F5 Insights Into Transcriptome Profiles Associated With Wooden Breast Myopathy in Broilers Slaughtered at the Age of 6 or 7 Weeks 2534 126669 2885 387 7408 3611 1398 998 572 PMC8278111__F1 Complex role of Wnt ligands in type 2 diabetes mellitus and related complications 1499 4040 4041 324 2932 607 4513 595 51701 6259 6714 998 387 PMC8278373__F2 Therapeutic approaches targeting the GFB in clinical or late preclinical development 7225 5879 387 7224 998 PMC8289466__F10 Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer 3792 351 2022 759 PMC8290014__F6 TLR4 in parthanatos and the MyD88 and/or the PI3K signaling pathway in parthanatos 4615 7099 1956 PMC8290830__F4 Autophagy in hepatic fibrosis 2475 10533 9474 8408 9776 9140 PMC8298003__F22 Skin as a critical window in unveiling the pathophysiologic principles of COVID-19 59272 718 727 7450 7018 PMC8301375__F1 XBP1s in Transcriptional Regulation of Target Genes 7494 1998 468 83939 22926 PMC8301375__F4 XBP1s in Transcriptional Regulation of Target Genes 5300 7494 2033 23411 3091 4609 PMC8303665__F2 Trastuzumab Mechanism of Action; 20 Years of Research to Unravel a Dilemma 6714 5728 2885 1956 PMC8306439__F3 Combining Oncolytic Viruses and Small Molecule Therapeutics: Mutual Benefits 2475 3667 5728 6009 5163 7249 7248 PMC8307089__F1 Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer? 3458 545 2241 29110 942 941 3146 PMC8318692__F2 Interleukin-17A (IL-17A): A silent amplifier of COVID-19 7054 59272 84818 3579 6364 PMC8319838__F3 Temozolomide resistance in glioblastoma - a comprehensive review 5728 572 1956 1950 2475 PMC8321669__F10 RNA-seq analysis indicates Chemical carcinogenesis inhibition in M3−/− crypts 4118 7808 81553 6497 4199 100653365 100187761 PMC8323830__F1 Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy 7518 472 675 672 5888 84126 545 PMC8329414__F2 Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer 306 7124 581 2475 PMC8330570__F7 THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy 10802 63892 6396 PMC8334350__F2 Schematic models for combinatorial C. elegans and mammalian system studies regarding the role of insulin/IGF-1 signaling, mTOR pathway, and sirtuins 2067 79631 2475 PMC8336005__F4 Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions 6660 55553 6662 4617 6423 1499 860 8321 2535 79971 7976 4040 6422 8325 4041 8323 90780 8322 6425 6424 64840 85409 85407 26108 PMC8336468__F7 Clostridium cellulovorans Proteomic Responses to Butanol Stress 7808 7054 7263 PMC8337009__F4 ICN: extracting interconnected communities in gene co-expression networks 7186 40 351 57136 4117 2019 4149 PMC8345931__F8 Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident 5473 6359 7124 284340 4254 6369 9049 941 942 7392 6357 6354 PMC8345981__F1 TGF-Beta as a Master Regulator of Diabetic Nephropathy 4092 1278 4089 4088 4087 7046 1282 1284 PMC8346999__F7 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases 84890 11101 197131 23304 PMC8346999__F9 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases 197131 23304 23352 65018 55486 PMC8346999__F11 Signaling Pathways Regulated by UBR Box-Containing E3 Ligases 163859 5111 197131 23304 56852 545 PMC8348875__F8 Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE) 581 595 1019 PMC8349734__F4 Drug-repurposing against COVID-19 by targeting a key signaling pathway: An in silico study 355 100187761 596 PMC8351219__F4 Molecular mechanisms of action of Nutlins in neuroblastoma cells 28996 4193 1869 PMC8353789__F1 Perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed? 22863 2475 9776 60673 7942 10013 PMC8359037__F7 Systematic summary of survival and death signalling during the life of hair follicle stem cells 4193 581 842 836 8772 PMC8361660__F6 Early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies 1019 896 1029 5925 898 1017 672 PMC8363725__F6 The biosynthesis of the nemamides 126006 5121 718 717 PMC8365026__F1 Endoplasmic Reticulum Stress in Cerebral Ischemia 54870 468 83939 22926 7494 PMC8365026__F3 Endoplasmic Reticulum Stress in Cerebral Ischemia 22926 83939 7186 PMC8373148__F7 Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms 468 10411 814 775 2776 PMC8375225__F7 Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer 8161 6774 1019 PMC8375263__F1 One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency 3717 8651 4615 114609 PMC8377231__F1 Mechanisms and Boundary Conditions of Drug Memory Reconsolidation 468 83939 1020 PMC8377544__F4 Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man 145258 1956 100187761 PMC8379503__F8 Impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation 4899 7019 23411 64802 10135 PMC8381650__F5 NFKB: At the Borders of Autoimmunity and Inflammation 50943 326 3662 6366 355 596 PMC8392871__F5 Novel Polyethylene Glycol-Conjugated Triazole Derivative with High Thyrointegrin AvB3 Affinity in Acute Myeloid Leukemia Management 5747 6714 51660 3976 4312 4319 PMC8393760__F4 Molecular Aspect of Nephrolithiasis Development 1373 5009 435 PMC8393842__F1 Adding Some “Splice” to Stress Eating: Autophagy, ESCRT and Alternative Splicing Orchestrate the Cellular Stress Response 2475 8408 9474 10533 83734 25978 128866 7251 PMC8395092__F2 Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes 613 940 324 941 942 920 PMC8396170__F2 RasV12; scrib−/− Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions 4321 23513 2241 6714 4312 PMC8397173__F8 Histidine Kinase Sln1 and cAMP/PKA Signaling Pathways Antagonistically Regulate Sporisorium scitamineum Mating and Virulence via Transcription Factor Prf1 466 7018 5551 PMC83988__F10 Signaling pathways for NFKB activation by IL-1B 4615 5879 998 7189 PMC8400201__F1 Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin 9776 22863 2475 PMC8400831__F4 CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literature 1636 3240 59272 7113 PMC8401727__F5 Physcomitrium patens Infection by Colletotrichum gloeosporioides: Understanding the Fungal–Bryophyte Interaction by Microscopy, Phenomics and RNA Sequencing 266710 759 847 2078 PMC8411238__F6 Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses 3091 7249 2475 PMC8422427__F6 Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications 7494 7186 468 83939 22926 3553 PMC8424979__F5 Tetraploidization event shaped the Aquilaria sinensis genome and contributed to the ability of sesquiterpenes synthesis 3652 3156 4597 2224 PMC8427689__F6 Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment 613 6850 930 2885 5879 5728 7249 572 4145 51083 672 5934 4602 126669 PMC8430083__F5 Comprehensive network analysis of different subtypes of molecular disorders in lung cancer 3685 1311 8434 1277 3371 9021 1636 177 6502 1869 695 4353 6347 PMC8432143__F2 Moving towards clinical trials for mitochondrial diseases 142 7019 5428 5442 PMC8433626__F5 Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine 8818 8813 54344 PMC8434532__F4 Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer 468 83939 22926 7494 PMC8438069__F6 Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS 9563 3553 3569 5226 PMC8438071__F8 In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy 581 142 5972 PMC8438693__F3 Protein phosphatase 2A in kidney disease (Review) 8772 8717 7186 PMC8438979__F4 UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve 4050 4049 1733 5228 PMC8441048__F7 Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology 6648 6649 6647 PMC8444018__F4 Temporary Regulatory Deviations and the Coronavirus Disease 2019 (COVID-19) PCR Labeling Update Study Indicate What Laboratory-Developed Test Regulation by the US Food and Drug Administration (FDA) Could Look Like 331 324 3712 4397 PMC8445727__F8 Active Ingredients and Potential Mechanisms of the Gan Jiang-Huang Qin-Huang Lian-Ren Shen Decoction against Ulcerative Colitis: A Network Pharmacology and Molecular Docking-Based Study 1950 3082 2621 50853 558 572 581 PMC8457726__F1 Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways 50964 51129 1499 324 147111 607 PMC8457986__F3 Positive Role and Mechanism of Herbal Medicine in Parkinson's Disease 114548 834 468 9817 572 PMC84608__F12 The central role of the E2F transcription factors in cell proliferation and apoptosis 990 993 94005 3486 PMC8465097__F5 Differences in Acid Stress Response of Lacticaseibacillus paracasei Zhang Cultured from Solid-State Fermentation and Liquid-State Fermentation 2638 7851 4149 92797 130589 10296 2717 PMC8465636__F6 Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation 467 468 6888 5723 10797 2936 PMC8466366__F1 Fungal Cell Wall Proteins and Signaling Pathways Form a Cytoprotective Network to Combat Stresses 1431 4957 998 4281 1255 PMC8469189__F2 Oral Cavity as a Source of Mesenchymal Stem Cells Useful for Regenerative Medicine in Dentistry 3569 9242 355 PMC8469858__F1 Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer 2621 558 5879 PMC8470495__F1 Promising Biomarkers of Radiation-Induced Lung Injury: A Review 3146 3490 1499 2475 51199 7448 3479 PMC8471942__F1 Genetic Aberrations of DNA Repair Pathways in Prostate Cancer: Translation to the Clinic 5888 2067 7515 5591 7520 2547 545 472 PMC8472298__F2 Insulin and Insulin Resistance in Alzheimer’s Disease 2475 3667 8660 PMC8473084__F5 Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) Promotes M1 Repolarization of Porcine Alveolar Macrophages and Th1 Type Response 4117 57506 1540 4599 4600 9636 9246 596 5580 5447 11274 1612 PMC8476931__F5 Chromosome-level genome assembly of Gynostemma pentaphyllum provides insights into gypenoside biosynthesis 3652 2873 4602 2077 PMC8484489__F3 AP2/ERF, an important cold stress-related transcription factor family in plants: A review 4602 23379 867 2077 PMC8491019__F5 Regulatory network driving shoot lignification in rapidly growing bamboo 4536 4602 1312 57716 PMC8495397__F3 Hippo pathway: a renewed insight in the craniofacial diseases and hard tissue remodeling 4615 7189 5970 4485 26524 9113 3596 PMC8500019__F3 Endothelial activation, dysfunction and immunothrombosis in COVID-19 59272 7018 100187907 7035 PMC8500950__F1 Smoking‐aggravated oral candidiasis: Nrf2 pathway dampens NLRP3 inflammasome 1728 114548 3553 PMC8501049__F10 CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling 6262 9927 90550 PMC8506026__F7 Crosstalk Between Abnormal TSHR Signaling Activation and PTEN/PI3K in the Dedifferentiation of Thyroid Cancer Cells 5728 7253 2475 387 PMC8507016__F1 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) 4041 324 1499 607 4316 PMC8507016__F2 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) 4040 4041 324 607 1499 2191 4316 PMC8507309__F5 RNA-Seq reveals different responses to drought in Neotropical trees from savannas and seasonally dry forests 9140 10533 83734 9776 60673 64422 9474 1879 64641 PMC8508945__F2 Translation Initiation Machinery as a Tumor Selective Target for Radiosensitization 5728 1977 7249 7248 PMC8510947__F2 STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function 9021 4513 6648 6651 6774 90550 PMC8515747__F9 Investigation of anti-osteoporosis mechanisms of Rehmanniae Radix Preparata based on network pharmacology and experimental verification 1956 2717 126669 2885 9166 596 3880 1509 5447 5914 PMC8519338__F1 Macrophage Activation Syndrome and COVID 19: Impact of MAPK Driven Immune-Epigenetic Programming by SARS-Cov-2 59272 929 7099 7098 4615 3553 PMC8526643__F2 What signals the glyoxalase pathway in plants? 4199 4478 22931 PMC8527165__F1 Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward 22944 4353 5409 7067 84890 1621 161823 PMC8529925__F1 Molecular testing for colorectal cancer: Clinical applications 5728 1956 2475 1950 PMC8533303__F6 Anticancer Targets and Signaling Pathways Activated by Britannin and Related Pseudoguaianolide Sesquiterpene Lactones 4609 2475 1977 PMC8543968__F6 Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium 6786 90550 7416 1956 4987 1019 PMC8548690__F6 Can the Cytokine Profile According to ABO Blood Groups Be Related to Worse Outcome in COVID-19 Patients? Yes, They Can 59272 7124 3605 PMC8564564__F4 Unfolding the role of autophagy in the cancer metabolism 7405 2475 8678 PMC8566352__F2 Plasmalogens and Chronic Inflammatory Diseases 95 8540 84188 PMC8567988__F6 Flavonoid Library Screening Reveals Kaempferol as a Potential Antiviral Agent Against African Swine Fever Virus 9140 22863 8408 64798 PMC8569340__F1 Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy 79923 3845 57650 PMC8570864__F5 Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology 8772 367 4340 2242 PMC8572706__F4 Therapeutic effects of Bombyx mori sericin on rat skin psoriasis through modulated epidermal immunity and attenuated cell proliferation 196 920 27040 3466 8168 256933 3725 6095 PMC8576090__F3 Bioprospecting of microalgae metabolites against cytokine storm syndrome during COVID-19 59272 4615 4015 PMC8582418__F3 Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment 2194 3418 2744 PMC8584253__F7 PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway 961 4609 6657 2475 PMC8584326__F1 Cross-Tolerance and Autoimmunity as Missing Links in Abiotic and Biotic Stress Responses in Plants: A Perspective toward Secondary Metabolic Engineering 578 4881 51411 PMC8584528__F1 Model Identifies Genetic Predisposition of Alzheimer’s Disease as Key Decider in Cell Susceptibility to Stress 7494 83939 468 22926 PMC8585084__F3 Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System 4734 4851 9776 22863 8678 8408 9474 9958 83734 7189 9140 23411 4591 84447 10533 201292 64422 PMC8586976__F4 Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics 637 596 581 1017 2021 22926 PMC8592567__F2 Candidate signaling cascades that mediate the action of Indigo and polysaccharides via the gut 9049 196 3661 PMC8599155__F3 Transient Receptor Potential Vanilloid Subtype 1: Potential Role in Infection, Susceptibility, Symptoms and Treatment of COVID-19 59272 7442 7113 PMC8601392__F4 Dynamic Interaction Between Mucosal Immunity and Microbiota Drives Nose and Pharynx Homeostasis of Common Carp (Cyprinus carpio) After SVCV Infection 8567 7706 6955 958 351 1633 6886 100188776 1208 PMC8602812__F4 Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites 47 941 942 790 6098 948 7054 PMC8603497__F4 Transcriptome and metabolome analysis to reveal major genes of saikosaponin biosynthesis in Bupleurum chinense 4598 4597 8213 3652 PMC8607366__F2 Targeting cardiomyocyte proliferation as a key approach of promoting heart repair after injury 4485 9113 26524 60485 3084 PMC8607427__F2 Post-translational modifications of CDK5 and their biological roles in cancer 4613 1958 1020 PMC8614792__F4 MicroRNA Sequencing Analysis in Obstructive Sleep Apnea and Depression: Anti-Oxidant and MAOA-Inhibiting Effects of miR-15b-5p and miR-92b-3p through Targeting PTGS1-NFKB-SP1 Signaling 5728 472 545 26511 2626 2582 914 1017 1019 759 PMC8615865__F3 Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment 100187761 847 5879 PMC8616039__F1 Emerging Therapeutic Landscape of Peripheral T-Cell Lymphomas Based on Advances in Biology: Current Status and Future Directions 238 2475 1233 PMC8616344__F7 Identification of Gene Co-Expression Networks Associated with Consensus Molecular Subtype-1 of Colorectal Cancer 4434 387569 2885 842 572 324 4089 581 2353 4609 51426 PMC8616463__F3 Global Reprogramming of Apoptosis-Related Genes during Brain Development 5966 7124 8772 8717 5447 581 831 6955 2021 7808 790 472 PMC8620939__F2 MTOR Pathway in Pluripotent Stem Cells: Lessons for Understanding Cancer Cell Dormancy 8408 23411 64223 64798 7249 7248 PMC8623382__F1 Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites 8877 6611 64781 340451 56848 PMC8623546__F5 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease 7249 2475 7248 6009 PMC8623546__F7 Nephronophthisis-Pathobiology and Molecular Pathogenesis of a Rare Kidney Genetic Disease 582 585 27031 324 2932 PMC8632384__F9 Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder 7124 7216 8772 8195 759 PMC8632388__F7 Hyperlipidemia May Synergize with Hypomethylation in Establishing Trained Immunity and Promoting Inflammation in NASH and NAFLD 948 114548 2475 7099 5728 4280 5465 2941 47 5091 PMC8635159__F3 An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease 2821 64841 10724 PMC8636667__F4 Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone 2534 2885 5163 5164 126669 10818 PMC8640549__F3 GPR56/ADGRG1 in health and disease 387 975 6010 7124 PMC8649520__F7 Schematic summary detailing the distinct UPR pathways regulated by hypercholesterolemia and aging within aortic and lung tissues in a murine model of atherosclerosis 22926 468 1998 348 PMC8650317__F1 Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts 5228 196 7216 PMC8660968__F1 Regulatory Mechanism of 2-Acetyl-1-Pyrroline Biosynthesis in Fragrant Rice (Oryza sativa L.) Under Different Soil Moisture Contents 1610 4942 5625 PMC8663935__F1 Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions 2885 7248 6009 5728 64798 64223 5163 7942 7030 8408 PMC8663982__F4 Cytokine signaling inhibition on inflammation-driven tissue remodeling 6772 2002 6774 PMC8669111__AF1 Glutathione synthesis primes monocytes metabolic and epigenetic pathway for Beta-glucan-trained immunity 2729 2146 2475 3099 2744 11113 PMC8674839__F2 Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits 7220 6786 6263 6262 84876 PMC8683220__F2 Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. 7124 7412 3383 PMC8692646__F1 mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication 7249 7248 6009 5728 8408 7942 PMC8699551__F5 Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger 8408 10533 9474 PMC8699626__F1 Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective 7791 4478 10129 4771 84962 4485 26524 PMC8699920__F1 Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer 1956 5163 6774 2885 PMC8712284__F4 Modular control of multiple pathways of Corynebacterium glutamicum for 5-aminolevulinic acid production 8066 51083 23237 7909 PMC8720586__F3 Target Deconvolution of Fenofibrate in Nonalcoholic Fatty Liver Disease Using Bioinformatics Analysis 3952 5914 3630 3643 367 5970 1050 100187761 468 581 PMC8739172__F4 Exploring the Mechanism of Panax notoginseng Saponins against Alzheimer's Disease by Network Pharmacology and Experimental Validation 2475 1636 7124 6520 2885 253260 2689 6010 PMC8742232__F3 Advances in the study of CDC42 in the female reproductive system 54556 5901 998 387 PMC8744686__F4 Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy 22926 468 5879 PMC8745220__F5 Combination of Genomic and Transcriptomic Approaches Highlights Vascular and Circadian Clock Components in Multiple Sclerosis 4117 1311 9575 PMC8745604__F4 YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises 1956 7939 1440 1435 1437 3579 PMC8745615__F2 Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins 2322 7084 2475 9100 8239 PMC8750061__F5 Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer’s Disease Patients 3315 847 407006 407007 406987 574452 664617 4281 PMC8753976__F3 Signal transduction mechanism of exosomes in diabetic complications (Review) 4485 4087 2114 3479 PMC8755416__F2 Renal consequences of the novel coronavirus disease 2019 (COVID-19) and hydrogen sulfide as a potential therapy 875 1610 59272 3553 3383 PMC8764384__F1 Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation 7494 468 83939 22926 PMC8770568__F1 Therapeutic targets identified in clinical and pre-clinical studies for ESR1 mutant breast cancer 1021 1019 3479 3480 2475 PMC8773517__F3 Oxysterols in the Immune Response to Bacterial and Viral Infections 5007 83939 468 9023 PMC8774087__F1 Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19 1636 59272 572 6868 PMC8774252__F2 Responsible Genes for Neuronal Migration in the Chromosome 17p13.3: Beyond Pafah1b1(Lis1), Crk and Ywhae(14-3-3E) 81565 1020 1600 1398 7436 PMC8778447__F1 Molecular Mechanisms Leading from Periodontal Disease to Cancer 3845 673 6774 595 PMC8782557__F1 Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases 64223 3667 23411 952 472 142 PMC8787213__F2 Research Advances in Multi-Omics on the Traditional Chinese Herb Dendrobium officinale 367 7358 80146 2444 2821 7504 4351 PMC8798197__F5 Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells 1956 5163 7248 7249 6009 572 PMC8810966__F12 Sex- and estrous-cycle dependent dorsal hippocampal phosphoproteomic changes induced by low-dose ketamine 717 5894 673 759 1264 6608 1390 PMC8815368__F3 BIRC5 was significantly enriched in the apoptosis pathway 8772 1616 637 572 100506742 4703 836 790 351 472 PMC8815517__F1 mTOR Signaling in Kidney Diseases 2932 7248 64798 5163 7249 6009 5728 64223 PMC8818883__F5 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis 8178 550641 4118 4117 51071 23237 PMC8818883__F6 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis 3929 130749 54472 4703 3661 958 PMC8824883__F2 Cell division control protein 42 in tumor and non-tumor diseases: A systematic review 1956 998 999 1499 PMC8825588__F2 Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment 5062 3984 382 324 7018 2475 5728 596 637 581 8772 545 1493 331 472 717 4609 PMC8825588__F5 Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment 9242 8829 7099 920 PMC8827057__F1 Experimental design 1893 4087 174 213 PMC8827382__F2 p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets 9776 8408 9706 22863 7405 55626 10533 64422 9140 9474 83734 PMC8836112__F1 Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport 3643 4205 23216 867 PMC8836162__F2 EphrinB2–EphB4 Signaling in Neurooncological Disease 3717 3265 6656 387 6237 PMC8847026__F12 “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer 1376 23152 5091 23530 47 PMC8848207__F1 Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy 7248 7405 1956 10533 9474 6774 83939 PMC8848207__F2 Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy 55353 1956 64422 2475 6774 PMC8861086__F3 Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease 27179 90865 4615 2475 5728 PMC8862475__F7 Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas 95 11113 2475 PMC8862784__F2 ACE2: a key modulator of the renin-angiotensin system and pregnancy 1636 3553 7124 59272 1728 PMC8863938__F2 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers 150365 581 572 PMC8863938__F3 Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers 83939 468 596 581 PMC8864737__F3 WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization 25859 7054 84890 PMC8869290__F1 Oligomannose-Type Glycan Processing in the Endoplasmic Reticulum and Its Importance in Misfolding Diseases 56886 55741 9695 80267 PMC8870715__F1 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements 4193 331 5728 5163 2475 595 1956 PMC8870715__F3 Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements 3920 3916 7405 22863 23410 2475 PMC8877377__F1 High Expression of Interferon Pathway Genes CXCL10 and STAT2 Is Associated with Activated T-Cell Signature and Better Outcome of Oral Cancer Patients 6418 6773 3627 PMC8883286__F3 Mechanisms Underlying Influence of Bioelectricity in Development 983 1017 1019 1021 PMC8883733__F2 Mucor circinelloides: a model organism for oleaginous fungi and its potential applications in bioactive lipid production 95 4118 11113 3652 PMC8888930__F1 Microglia Polarization From M1 to M2 in Neurodegenerative Diseases 7099 4615 7189 23411 PMC8889522__F2 An insight into the mechanisms of COVID-19, SARS-CoV2 infection severity concerning Beta-cell survival and cardiovascular conditions in diabetic patients 59272 7113 1636 6868 PMC8897051__F2 Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions 6774 2475 4193 1499 PMC8899168__F7 4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway 2729 1728 9817 PMC8901995__F5 Evaluation of Public–Private Partnership in the Veterinary Domain Using Impact Pathway Methodology: In-depth Case Study in the Poultry Sector in Ethiopia 26509 9081 6395 55364 PMC8904967__F2 Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer 23657 2937 2879 PMC8910224__F4 Micro-Current Stimulation Suppresses Inflammatory Responses in Peptidoglycan-Treated Raw 264.7 Macrophages and Propionibacterium acnes-Induced Skin Inflammation via TLR2/NFKB Signaling Pathway 7097 4615 7189 PMC8910341__F1 Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits 933 971 613 930 4067 695 6850 102724566 8915 2638 PMC8910922__F1 Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases 9817 8452 192668 7038 1020 PMC8917441__F7 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis 5891 7018 226 10763 351 PMC8917441__F8 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis 8772 831 351 445347 790 PMC8917441__F10 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis 5728 831 5478 4609 759 9575 PMC8917441__F11 Prediction of the Active Components and Possible Targets of Xanthii Fructus Based on Network Pharmacology for Use in Chronic Rhinosinusitis 929 54472 114609 5447 8772 PMC8918699__F1 Large granular lymphocytic leukemia: a brief review 355 8772 6774 5163 4170 6667 PMC8919722__F8 PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂ 1611 2919 6347 7124 85451 PMC8921549__F4 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury 5925 581 23411 PMC8929128__F1 Impact of Vitamin D Supplementation on Inflammatory Markers’ Levels in Obese Patients 7421 55179 1593 6376 PMC8929360__F3 New insights into the role of melatonin in diabetic cardiomyopathy 83939 468 22926 23411 PMC8931059__F3 CD95-dependent non-apoptotic signaling 2475 5728 5335 84876 PMC8931742__F1 Schematic depicting the ER stress response signaling pathway after SCI 468 22926 7494 PMC8934427__F2 Interplay Between Coronavirus and Type I IFN Response 57506 3661 6773 10379 759 PMC8946148__F2 Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy 64223 64798 6009 5163 7249 7248 5728 1956 253260 PMC8950262__F1 Tissue-Specific Expression of the Terpene Synthase Family Genes in Rosa chinensis and Effect of Abiotic Stress Conditions 4598 4597 3652 PMC8957998__F8 Inspiration for COVID-19 Treatment: Network Analysis and Experimental Validation of Baicalin for Cytokine Storm 7124 4199 7186 4632 7975 339855 4703 4117 7054 637 6651 1431 10129 PMC8959092__F3 Repurposed drugs targets in ovarian cancer 4513 2475 6657 79923 PMC8961590__F1 Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases 768219 2932 79727 5728 3190 2475 3643 8660 3667 29102 54487 54715 23543 PMC8971730__AF1 CCL18 promotes breast cancer progression by exosomal miR-760 activation of ARF6/Src/PI3K/Akt pathway 6362 382 6714 PMC8979796__F4 Metabolic pathways regulating the development and non-genomic heritable traits of germ cells 6472 6470 4524 PMC8980269__F2 PI3K/Akt/mTOR Signaling Pathway: Role in Esophageal Squamous Cell Carcinoma, Regulatory Mechanisms and Opportunities for Targeted Therapy 64798 64223 5728 5163 7249 6009 PMC8982613__F6 Infantile hepatic hemangiomas: looking backwards and forwards 3099 3939 2475 5728 100188864 PMC8986524__F3 Molecular mechanisms underlying the emergence of polygenetic antifungal drug resistance in msh2 mismatch repair mutants of Cryptococcus 8724 64601 23339 110740339 PMC8996999__F2 Posttranslational Modifications in Thyroid Cancer: Implications for Pathogenesis, Diagnosis, Classification, and Treatment 5728 2932 1499 5163 2475 2309 PMC8998487__F3 SUMO E3 Ligases in Signaling Pathway of Cancer Cells 84464 51588 7431 5879 64750 10401 26036 117581 5371 5728 PMC8998814__F4 Metastasis and MAPK Pathways 1956 5879 998 PMC9003189__F2 Amino Acid-Related Metabolic Signature in Obese Children and Adolescents 64798 6009 7249 7248 PMC9004553__F8 Construction and evaluation of a nomogram for predicting survival in patients with lung cancer 990 8317 10926 6502 991 9833 24137 2146 7083 27338 9319 1033 83461 3161 332 10615 701 6241 11004 7153 29089 9232 1164 4605 57405 PMC9005359__F5 Risk-Related Genes and Associated Signaling Pathways of Gastrointestinal Stromal Tumors 59341 3135 472 545 780904 28996 2626 9902 5478 PMC9008482__F2 mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate 23367 2475 83939 1977 1999 1998 PMC9009290__F9 Chrysin Ameliorates Influenza Virus Infection in the Upper Airways by Repressing Virus-Induced Cell Cycle Arrest and Mitochondria-Dependent Apoptosis 1019 1017 581 183 PMC9010822__F2 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances 6608 246744 6469 PMC9016280__F2 Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases 2475 572 23411 PMC9024148__F6 Multi-Omics Characterizes the Effects and Mechanisms of CD1d in Nonalcoholic Fatty Liver Disease Development 276 337 1544 133 9415 2950 5144 2947 PMC9027630__F2 Osteopontin in Microglia Biology: Current Concepts and Future Perspectives 960 5163 5879 998 PMC9029125__F2 Impact of Treadmill Interval Running on the Appearance of Zinc Finger Protein FHL2 in Bone Marrow Cells in a Rat Model: A Pilot Study 6667 6714 11279 2274 860 PMC9030443__F3 Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies 2314 64359 7099 815 11231 139285 5879 27035 PMC9030951__F3 The Homeostatic Unfolded Protein Response in Diabetic Nephropathy 324 23411 7494 22926 PMC9033251__F1 How compensatory mechanisms and adaptive rewiring have shaped our understanding of therapeutic resistance in cancer 2887 1021 1019 253260 2475 3643 3667 8660 1975 5163 7249 7248 6009 1977 1956 PMC9033823__F6 Oncogenic circuit involving FUS-DDIT3, the IGF-IR/PI3K/AKT pathway, and the Hippo/YAP1 axis in MLS 10413 9113 3481 PMC9033932__F3 Targeting TGFB signal transduction for fibrosis and cancer therapy 4089 80176 2922 PMC9035223__F1 Fleshy fruit ripening: from transcription factors to epigenetic modifications 378 2077 4602 PMC9036418__F1 3q26 CNG activates PKCι-driven oncogenic signaling pathways in LUSC 1894 5879 5058 6657 PMC9045034__F3 Anti-tuberculosis drug candidate pipeline and mechanism of drug action 4322 4312 4553 PMC9048014__F5 Candidates for Biomarkers in Bipolar Disorder: A Proteomic Approach through Systems Biology 2152 7035 2159 2147 2161 7450 1361 5091 2 5340 2271 718 1431 966 1380 PMC9080202__F1 Sestrin2 in cancer: a foe or a friend? 847 7249 8408 PMC9083544__F1 Engineering Yarrowia lipolytica to Produce Itaconic Acid From Waste Cooking Oil 790 11113 5192 PMC9084498__F1 Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity 1312 1431 95 PMC9093074__F2 Dual-Targeted Therapy Circumvents Non-Genetic Drug Resistance to Targeted Therapy 545 472 6714 7465 983 PMC9094073__F1 Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy 7249 7248 6009 PMC9094111__F1 Calcium Mediated Cold Acclimation in Plants: Underlying Signaling and Molecular Mechanisms 867 4609 8195 PMC9101507__F4 Endocytosis at the Crossroad of Polarity and Signaling Regulation: Learning from Drosophila melanogaster and Beyond 11021 1956 1950 PMC9103147__F3 Proteostasis Perturbations and Their Roles in Causing Sterile Inflammation and Autoinflammatory Diseases 4193 115004 1081 3661 PMC9107190__F9 Label-free LC–MS/MS proteomics analyses reveal proteomic changes in oxidative stress and the SOD antioxidant strategy in TM cells 1636 1610 4089 8213 6401 4313 7124 5300 PMC9107641__F2 Metabolic engineering of Clostridium ljungdahlii for the production of hexanol and butanol from CO2 and H2 3045 100187828 1690 55749 5447 PMC9112456__F1 Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives 6608 51684 374654 2932 156 PMC9112604__F3 Endotheliitis, Shunts, and Ventilation–Perfusion Mismatch in Coronavirus Disease 2019: A Literature Review of Disease Mechanisms 5045 7113 59272 1636 PMC9124774__F1 Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment 5728 5163 2475 7248 PMC9127500__F9 Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway 1017 468 2475 PMC9138936__F4 Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer’s Disease 10013 3916 7405 100170220 PMC9156734__F4 Localization and function of different molecules involved in the PI3K/AKT signalling pathway in the CE 3082 3479 4827 PMC9157426__F3 Therapeutic Effect of SCFA-Mediated Regulation of the Intestinal Environment on Obesity 1636 5697 51129 PMC9161817__F1 Autophagy and the Bone Marrow Microenvironment: A Review of Protective Factors in the Development and Maintenance of Multiple Myeloma 9474 22926 468 PMC9162456__F3 Natural and engineered metabolic pathways to biofuels 133 49 196 2191 26136 84890 3652 PMC9166529__F2 Characteristics of the cancer stem cell niche and therapeutic strategies 2475 6657 79923 PMC9166529__F4 Characteristics of the cancer stem cell niche and therapeutic strategies 22943 324 2932 1499 6608 51684 PMC9168090__F9 Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine 858 859 5266 3270 90550 PMC9168780__F10 Emerging roles of cystathionine Beta-synthase in various forms of cancer 5728 875 10645 2475 PMC9169637__F7 Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion 654231 7852 2475 5728 PMC9170180__F1 Three Proliferation Pathways (Wnt, Notch, and Hippo) in Intestine and Immune System and Their Role in Inflammatory Bowel Diseases (IBDs) 324 9113 102 PMC9170603__F3 MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers 6714 6774 3578 3586 3569 3589 246778 59067 PMC9175009__F2 Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics 4615 5763 114548 201292 79792 6737 3553 8772 PMC9175095__F8 Exosomal CTCF Confers Cisplatin Resistance in Osteosarcoma by Promoting Autophagy via the IGF2-AS/miR-579-3p/MSH6 Axis 10664 51214 2956 PMC9178660__F4 Advances in Immunosuppressive Agents Based on Signal Pathway 145258 9817 8452 5493 PMC9178660__F5 Advances in Immunosuppressive Agents Based on Signal Pathway 2002 2885 1950 PMC9179367__F1 Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares 10135 160728 93100 PMC9179380__F1 NOTCH1, GATA3, and c-MYC in T Cell Non-Hodgkin Lymphomas 196 2625 4087 4088 3566 3662 920 940 50943 958 604 367 50615 29851 2308 7054 PMC9179574__F3 Genetic Structure and Molecular Mechanisms Underlying the Formation of Tassel, Anther, and Pollen in the Male Inflorescence of Maize (Zea mays L.) 6688 2221 6654 PMC9180116__F4 O-GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology 55577 8473 2821 10724 10020 85569 2733 5132 2582 3667 8660 1431 6120 2271 107966124 PMC9181071__F1 Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway 1950 4615 3066 7038 2475 PMC9181147__F4 Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review 9776 22863 9821 9140 9474 55054 64422 10533 PMC9181879__F1 Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways 1956 2885 5728 6009 7249 7248 324 1499 64750 4087 4088 PMC9182524__F3 Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer 5728 5230 572 PMC9194156__F5 Neurodevelopmental disorders, immunity, and cancer are connected 2885 10818 64798 2475 2002 2549 PMC9200208__F3 Low-dose tissue plasminogen activator in patients with refractory hypoxia due to presumed microthrombi in pulmonary vasculature in coronavirus disease 2019: A case series and review of the literature 2717 1636 5340 PMC9206341__F8 Near-infrared light reduces Beta-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease 7097 7099 2539 3606 6714 PMC9207209__F3 Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism 55276 5230 2023 2026 9377 9001 1537 3417 4512 1329 48 50 PMC9213371__F1 NFKB in control of regulatory T cell development, identity, and function 5970 50943 2157 5971 PMC9220936__F2 MicroRNAs in the Regulation of Solute Carrier Proteins Behind Xenobiotic and Nutrient Transport in Cells 6513 100126323 23657 6520 2475 100302228 PMC9221026__F1 Translational Regulation in mTOR Pathway 7248 7249 6009 2475 5728 64223 253260 PMC9223569__F1 Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy 6611 2531 1674 7368 64781 PMC9235346__F3 Integrating proteomic and clinical data to discriminate major psychiatric disorders: Applications for major depressive disorder, bipolar disorder, and schizophrenia 1356 1520 629 7035 3053 2861 10577 7018 4153 1071 7054 PMC9237930__F2 New dawn for cancer cell death: Emerging role of lipid metabolism 10919 4199 6721 51548 23411 79968 948 9415 10226 123 22937 3638 2194 PMC9240199__F3 Emerging Roles of Human Gut Microbiota in Gastrointestinal Cancer 581 8829 6667 1982 2475 PMC9243343__F2 Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy 2475 6093 10146 9100 10399 PMC9243434__F1 Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development 2475 7494 627 PMC9250200__F2 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis 440 2475 2166 1000 7473 343 PMC9261320__F1 Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases 22926 83939 468 7494 7186 PMC9261320__F2 Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases 22926 83939 468 79866 7494 7186 PMC9265429__F3 Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases 64223 64798 6009 7249 7248 9817 PMC9266441__F2 Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NFKB Signaling Pathway 1081 4512 4615 114609 3654 51135 7189 7099 3661 PMC9266903__F1 Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment 8031 3162 2879 2182 4015 PMC9270311__F2 Effects of Ginsenosides on PI3K/AKT signaling pathway 3156 2932 2308 PMC9271868__F1 Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology 5091 54947 4049 83550 4018 2853 4056 2861 9290 59352 PMC9277163__F11 Protective Effects of Cinnamaldehyde on the Oxidative Stress, Inflammatory Response, and Apoptosis in the Hepatocytes of Salmonella Gallinarum-Challenged Young Chicks 2475 7249 7248 2932 PMC9278015__F4 Significance of interferon signaling based on mRNA-microRNA integration and plasma protein analyses in critically ill COVID-19 patients 4397 102465802 128486 PMC9280276__F2 Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer 1956 2475 367 6520 4495 23657 2879 PMC9280721__F1 MTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation 9675 64798 2475 64223 6446 7249 7248 PMC9288288__F9 Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases 6770 6886 351 9118 7054 PMC9301135__F1 Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease 6009 7249 7248 64798 3611 3654 51135 7189 23411 23118 257397 5879 9817 PMC9306014__F1 CDK4 stabilization and canonical function in the cell cycle 1019 4609 7428 11140 PMC9312706__F3 Drug Repurposing: The Mechanisms and Signaling Pathways of Anti-Cancer Effects of Anesthetics 5163 2475 5728 983 PMC9313267__F2 Mechanism and Role of ADAMTS Protein Family in Osteoarthritis 4843 7432 1311 PMC9315226__F1 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? 983 673 2353 PMC9315226__F4 ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? 673 120892 23476 PMC9315518__F8 Identification and Functional Analysis of Individual-Specific Subpathways in Lung Adenocarcinoma 4092 4087 4088 154796 324 174 6657 3398 4811 PMC9315518__F10 Identification and Functional Analysis of Individual-Specific Subpathways in Lung Adenocarcinoma 6502 4172 4999 23594 4176 4087 4088 4089 1017 1869 1045 1537 990 4193 5111 1022 8318 8317 10926 3240 699 4661 9184 9126 10274 10735 991 999 PMC9316990__F3 Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases 545 472 9656 PMC9321669__F5 Dissimilative Pathway of Komagataella phaffii (Pichia pastoris): Formaldehyde Toxicity and Energy Metabolism 1506 4118 351 PMC9322659__F7 Comparing Transcriptomes Reveals Key Metabolic Mechanisms in Superior Growth Performance Nile Tilapia (Oreochromis niloticus) 37 47 2194 23411 PMC9322890__F11 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) 54106 4615 3654 51135 7189 23118 10454 114548 9817 3553 PMC9324879__F8 New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition 1956 4512 4513 PMC9325865__F1 Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) 7494 1998 468 83939 22926 PMC9326259__F9 Mechanism and Molecular Targets of Ejiao Siwu Decoction for Treating Primary Immune Thrombocytopenia Based on High-Performance Liquid Chromatograph, Network Pharmacology, Molecular Docking and Cytokines Validation 7035 2160 7450 2157 1361 2271 718 1431 930 1380 PMC9329783__F1 Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms 5330 29850 255022 PMC9329783__F3 Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms 5330 29850 255022 6774 PMC9332011__F1 Hsp90 and Associated Co-Chaperones of the Malaria Parasite 11140 367 2925 PMC9338059__F2 KOPI: Kinase inhibitOr Proteome Impact analysis 9967 85021 7155 6449 412 2235 5159 6010 4841 5605 331 4609 10010 1956 31 1506 PMC9339493__F2 Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review) 4513 6774 2535 7472 1499 7471 324 PMC9351107__F3 Targeting KRAS mutant cancers: from druggable therapy to drug resistance 3845 6654 2475 PMC9352922__F3 PKCA and PKCD: Friends and Rivals 994 983 1019 1017 2475 6714 PMC9356176__F12 The cystathionine Beta-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome 2597 5723 47 355 1431 5640 PMC9356732__F4 Comparative Genomics of the Waterfowl Innate Immune System 7054 8405 9140 7186 4117 5603 1147 4792 3627 3592 PMC9361020__F1 Endoplasmic reticulum stress in innate immune cells - a significant contribution to non-alcoholic fatty liver disease 7494 83939 468 22926 PMC9367940__F9 Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca2+, cAMP and ACh 29850 1080 3784 PMC9373848__F1 Autophagy in Adrenal Tumors 55626 9140 9474 10533 8411 3916 PMC9380231__F6 Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing 4862 1906 4314 2006 59 PMC9388302__F2 Essential Role of FoxO1 in the Regulation of Macrophage Function 5163 2308 23411 51548 5371 PMC9392712__F2 Targeting autophagy as a therapeutic strategy against pancreatic cancer 8408 9776 60673 22863 23192 10533 64422 9140 9474 55054 PMC9393183__F3 Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression 5648 59272 5340 PMC9393521__F1 Current therapeutic strategies and perspectives in refractory ITP: What have we learned recently? 613 6850 695 2475 PMC9399644__F5 Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy 6714 4087 4088 1956 PMC9405604__F4 Depletion of Mdig Changes Proteomic Profiling in Triple Negative Breast Cancer Cells 2000 6194 1999 10682 7186 8139 10808 10956 PMC9406846__F2 Clinical and Molecular Implications of Osteopontin in Heart Failure 7018 960 55753 PMC9406846__F4 Clinical and Molecular Implications of Osteopontin in Heart Failure 545 2002 2475 PMC9409119__F2 Emerging Key Role of the mGluR1-PKCG Signaling Pathway in the Pathogenesis of Spinocerebellar Ataxias: A Neurodevelopmental Viewpoint 85397 3632 9262 PMC9413556__F1 Targeting IRE1Alpha-JNK-c-Jun/AP-1-sEH Signaling Pathway Improves Myocardial and Coronary Endothelial Function Following Global Myocardial Ischemia/Reperfusion 83939 468 22926 7494 PMC9423097__F2 Interplay between Helicobacter pylori and the gut microbiota: An emerging driver influencing the immune system homeostasis and gastric carcinogenesis 114548 920 50943 PMC9437261__F7 Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice 8087 355 4318 6774 3716 PMC9451157__F5 Pathway and mechanism analysis of F1-mediated chemoenzymatic synthesis of benzimidazole 6418 720 847 PMC9456274__F1 Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation 9350 204219 91012 PMC9456385__F1 Reactive Oxygen Species and Long Non-Coding RNAs, an Unexpected Crossroad in Cancer Cells 7124 9817 5728 472 4193 2475 581 PMC9456457__F1 Insulin Receptor Substrate Proteins in Bronchopulmonary Dysplasia and Asthma: New Potential Perspectives 2885 2475 5728 PMC9458025__F3 Functional Annotation of Lactiplantibacillus plantarum 13-3 as a Potential Starter Probiotic Involved in the Food Safety of Fermented Products 7504 7454 126669 666 2022 213 847 PMC9462662__F2 Relationship of alpha-synuclein to mitochondrial dynamics and quality control 9342 100170220 4397 10133 65018 PMC9468880__F2 Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells 652968 29904 1977 7249 7248 6009 2475 4488 5163 5728 253260 6446 PMC9471064__F5 Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets 10533 64422 23192 55626 22863 2475 9776 8408 60673 100187761 PMC9476305__F5 Recent advances and limitations of mTOR inhibitors in the treatment of cancer 2475 5163 7248 7249 6009 5728 3480 3667 1977 PMC9476772__F10 Assessment of pulmonary infectious disease treatment with Mongolian medicine formulae based on data mining, network pharmacology and molecular docking 5970 339855 8205 351 100187761 4322 PMC9477170__F3 Inflammation resolution concept 4513 4512 114548 3596 PMC9481929__F8 Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin 999 1499 5879 PMC9486121__F2 Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities 5728 5163 2475 PMC9495541__F6 Cynanoside F Controls Skin Inflammation by Suppressing Mitogen-Activated Protein Kinase Activation 3553 85480 4014 PMC9495798__F9 Physiological and Comparative Transcriptome Analysis Reveals the Mechanism by Which Exogenous 24-Epibrassinolide Application Enhances Drought Resistance in Potato (Solanum tuberosum L.) 51411 1636 8205 7054 100187761 7454 PMC9496462__F1 Dynamic Regulation of NFKB Response in Innate Immunity: The Case of the IMD Pathway in Drosophila 3065 8772 23118 1540 PMC9497173__F3 Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment 8408 60673 9776 9706 22863 23192 10533 64422 9140 9474 55054 PMC9497596__F7 Full-Length Transcriptome Sequencing Combined with RNA-Seq to Analyze Genes Related to Terpenoid Biosynthesis in Cinnamomum burmannii 4598 3652 4200 PMC9512240__F1 Radiation-induced Cell Death and Its Mechanisms 998 5879 54205 PMC9513370__F3 Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis 50943 7124 196 PMC9523121__F1 Hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review 22926 5443 4852 181 468 83939 7494 9021 PMC9526834__F1 Dietary Patterns and Gut Microbiota: The Crucial Actors in Inflammatory Bowel Disease 197259 2475 6965 PMC9527825__F1 Possible mechanisms for ANGPTL1 attenuating CRC liver metastasis 406929 117581 6657 4318 PMC9531149__F3 Role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy 3002 6120 1003 PMC9535304__F2 Molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NFKB pathway under oxidative stress 9817 571 8452 9978 8454 4094 PMC9540541__F2 Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone 4199 7054 270 5192 PMC9542548__F5 Mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo 2056 3263 151176 57817 780904 26136 2512 338340 2034 212 PMC9546106__F2 Neutrophil granule proteins in orchestrating inflammation and immunity 54106 6850 5880 1794 3055 2268 PMC9546682__F7 Yangxin Tongmai Decoction in the Treatment of Coronary Heart Disease with Blood Stasis Syndrome Based on Network Pharmacology and Molecular Docking 6850 2885 351 5728 434 1311 2475 572 51083 4609 4602 PMC9549314__F7 We are all aging, and here's why 2885 5163 5728 27068 PMC9550700__F8 Contribution of the Immune Response in the Ileum to the Development of Diarrhoea caused by Helminth Infection: Studies with the Sheep Model 367 84957 3977 7292 5008 8205 PMC9554952__F4 Review of Herbal Medicine-Based Phytochemical of Garcinia as Molecular Therapy for Breast Cancer 1956 6009 5728 5163 7249 7248 6774 PMC9555684__F1 Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast 2078 95 3652 PMC9557748__F5 Terpenoids and their gene regulatory networks in Opisthopappus taihangensis ‘Taihang Mingzhu’ as detected by transcriptome and metabolome analyses 4598 4597 3652 PMC9563254__F5 p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond 999 6774 6657 79923 4609 1499 4087 4088 1958 PMC9564263__F1 Systematic Interrogation of the Temperature Perturbation in the Insulin Signaling Pathway for Optogenetic Stimulation 3643 3667 5163 2932 PMC9570456__F2 Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment? 4907 132 84890 100 PMC9574357__F2 IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers 3976 51284 54106 4615 847 2590 761 759 51083 PMC9576411__F2 Oxidative Stress and Intervertebral Disc Degeneration: Pathophysiology, Signaling Pathway, and Therapy 9817 4513 114548 PMC9578855__F7 Eucommia ulmoides Oliver's Multitarget Mechanism for Treatment of Ankylosing Spondylitis: A Study Based on Network Pharmacology and Molecular Docking 920 6886 100187907 PMC9579336__F3 Synthesis, function, and regulation of sterol and nonsterol isoprenoids 3156 29914 54704 PMC9584744__F2 Effect of Liraglutide on Serum TSH Levels in Patients with NAFLD and its Underlying Mechanisms 23269 6955 3371 572 3240 PMC9587090__F2 Cellular senescence and acute kidney injury 1021 1019 595 983 1017 PMC9593040__F2 Mitophagy in the aging nervous system 11337 65018 100187761 PMC9599458__F3 Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities 3569 50507 2475 PMC9600272__F2 Emerging Role of ERBB2 in Targeted Therapy for Metastatic Colorectal Cancer: Signaling Pathways to Therapeutic Strategies 6655 2885 2475 5163 4609 7422 29110 7018 1950 PMC9600852__F1 Molecular Defense Response of Pine Trees (Pinus spp.) to the Parasitic Nematode Bursaphelenchus xylophilus 4015 847 1312 412 PMC9603842__F4 Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review 5163 355 8772 841 836 6774 PMC9607181__F1 Important Hormones Regulating Lipid Metabolism 5163 79071 2194 PMC9609640__F7 SmMYB4 Is a R2R3-MYB Transcriptional Repressor Regulating the Biosynthesis of Phenolic Acids and Tanshinones in Salvia miltiorrhiza 4602 3652 340451 PMC9707069__F2 From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling 374654 2619 91653 860 51684 6608 5879 387 PMC9961805__F1 E’Jiao on Skeletal Mineralisation, Osteocyte and WNT Signalling Inhibitors in Ovariectomised Rats 4040 4041 324 50964 PMC9994446__F3 Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin 1610 8454 6500 PMC10034899__F1 Sirtuins in attenuating plaque vulnerability in atherosclerosis 3146 114548 3569 PMC10036590__F4 Targeting CLDN18.2 in cancers of the gastrointestinal tract: New drugs and new indications 2475 3084 51208 PMC10041561__F15 Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs 7124 2006 5624 8139 8168 PMC102215__F1 Pathways to Lignin Monomers.The “metabolic grid” shown in this scheme incorporates the results of recent studies suggesting previously unexpected substrate specificities for F5H and COMT (; ; ) 1690 1312 790 PMC1140402__F2 The central carbon metabolism of E 1636 4118 11113 10724 PMC128926__F2 Activation of the NFKB pathway by IL-1 3656 7189 602 4615 3554 PMC1316260__F6 Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway 1950 5335 126669 PMC1395315__F1 Methionine-Homocysteine metabolism and related pathways 4507 7298 1719 29958 635 4552 27232 10588 4524 191 875 132 1491 2539 PMC1448211__F7 Real time pathway analysis of cell-cycle related genes mediated via TS overexpression in HCT-C18 (TS+) cells using actual gene expression data 545 351 11316 PMC1464269__F1 Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies 11113 84890 4118 7038 PMC1479816__F3 Pathways involved in mesenchymal cell proliferation and differentiation induced by G protein coupled receptors (GPCRs) 2885 387 2475 6010 PMC1483149__F1 Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony 2475 5091 355 PMC1483167__F1 Liver X receptor opens a new gateway to StAR and to steroid hormones 19 1583 355 3949 PMC1507568__F3 The p53 response is triggered by many different stresses involving both DNA-damaging and non-DNA-damaging agents 1499 1869 4609 PMC1550314__F1 Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells 1956 1839 2885 PMC155392__F3 Predicted pathways for degradation, transport, and metabolism of chitin by M 27159 1356 4668 PMC1599931__F1 Phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway 5163 6009 1977 PMC1679905__F6 Signalling routes emanating from the epidermal growth factor receptor (EGFR) 1950 126669 2885 1956 PMC1698511__F3 PKR is an intermediary component in TLR signaling 114609 4615 23586 7189 23118 257397 3661 3665 PMC1698636__F6 F igure 6.— 116844 10993 997 PMC1774275__F4 The chromosomal instability (CIN) pathway (see text for details) 699 51176 324 PMC1794588__F3 Small subnetwork identified for the shift from glucose to ethanol as carbon source 64853 1636 5569 4118 PMC1815248__F5 Co-option of a developmental pathway by invasive tumors 23513 4312 4313 8434 PMC1876750__F2 Focal Adhesions Regulate AB Signaling & Cell Death in Alzheimer’s Disease 847 9817 2186 PMC1934395__F2 Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events 7038 1401 3383 7056 324 2153 PMC1937523__F3 Comparison between the gene expression profiles and predicted substrate uptake rates 85569 5805 2582 2592 2695 4118 11113 1738 PMC1937548__F4 Comparison of nonsynonymous substitution rates among members of RB and p53 signaling pathways 4193 1021 1019 PMC1949901__F1 Current understanding of the pathways of fatty acid synthesis which are known to occur within the Brassicaceae 355 5091 718 PMC1952634__F4 Evolving biology and treatment of prostate cancer 6462 2885 5728 367 PMC1958996__F2 Transcriptional control of adipocyte formation 1019 1869 1874 PMC1963416__F1 Signaling mechanisms for the activation of HAT and HDAC 4803 55869 3065 3066 PMC199181__F2 Proposed mechanisms of NFKB activation in HIV-1–infected cells 920 7186 8772 PMC1994616__F2 New molecularly targeted therapies for lung cancer 6608 102 324 PMC1998884__F1 Pathways involved in GSIS 283871 4118 5132 5091 23152 1431 4397 PMC2048738__F1 Reactions of the Calvin cycle, starch synthesis, photosynthetic carbon oxygenation pathway, triose-P export, and Suc synthesis represented in the model (Supplemental Appendix S1, A and B) 2695 25801 3250 PMC2075035__F4 Scheme of the LNB/GNB pathway in B 51083 2592 101448070 2582 PMC2100400__F2 Innate and Adaptive Immune Response to Apoptotic Cells 2621 4240 5091 1401 PMC2106369__F1 Schematic overview of the RANK-NFKB signalling pathway 7189 23118 10454 7415 PMC2173020__F1 Cross-talk between growth factors and integrins in endothelial cells 6850 6714 581 PMC2192627__F1 Signaling mechanisms involved in lifespan regulation and the cellular response to genotoxic stress 3479 3480 3667 472 7248 2475 7249 23411 PMC219483__F1 Biochemical pathways of TSH and folate metabolism in Leishmania 1719 2356 4524 875 2937 PMC2233667__F6 Computational and Experimental Analysis of Redundancy in the Central Metabolism of Geobacter sulfurreducens 5091 1431 5447 PMC2234347__F2 CNX/CRT cycle 10956 80267 55741 PMC2257939__F2 Bimodal genes highlighted in KEGG ECM-receptor interaction diagram 960 7450 1101 948 84890 961 PMC2258669__F1 Genomic and functional context of glycerate kinase enzymes in bacteria 3250 3240 157739 375057 PMC2258669__F3 Enzymatic reactions and assays 1356 4827 2597 3250 2712 PMC2293256__F4 Reannotation processes 4507 4826 65220 PMC2311419__F1 P. gingivalis accelerates gingival epithelial cell progression through the cell cycle 595 993 7465 PMC2322867__F2 Rapid Signaling Mechanisms of Estrogens in the Developing Cerebellum 1839 1956 2885 6714 PMC2360674__F8 Schematic of porphyrin-synthetic pathway to illustrate potential control points for increased PpIX accumulation 210 4151 130749 PMC2375563__F1 Muscle growth: no IGFs, ands, or buts 6009 7249 2475 4609 1977 PMC2377014__F10 BDNF enhancement of glutamate-induced phase shifting in the SCN, and potential locations in the signaling pathway where ethanol could inhibit this process 627 6714 717 2638 PMC2395050__F1 PG-recycling pathway of the wild type (A) and trapping of anhMurNAc-tripeptide in an ampD mutant (B) 4352 4351 1611 PMC2423297__F9 The role of cAMP-stimulated adipogenesis via PKA- end Epac1-dependent processes 3479 2885 6010 PMC2442833__F1 Metabolic network of oryza sativa L 2695 11113 4118 PMC2476215__F3 Brick by brick: metabolism and tumor cell growth 355 3939 2744 PMC2494567__F10 Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure 7485 7039 1956 PMC2526691__F2 Focal adhesion pathway interaction map 759 8205 100653365 PMC2529154__F4 Four components to yield MDP chromophore 4693 717 730 718 729 727 PMC2538516__F1 Biosynthetic relationships between amino acids, as defined by their biosyntheses and their relationships with the glycolytic pathway and the citric acid cycle 199720 7349 1611 57530 PMC2567351__F2 MAPK Signaling Pathway 27040 1610 4351 4149 PMC2575825__F9 Redox-sensitive steps in hypothetical redox signaling pathways 7039 1956 3479 5728 6714 79400 7099 PMC2583496__F2 Global regulation of the E 22934 1401 3240 5970 PMC2588608__F2 Pathway Annotation and Summary Hit Table 176 3240 1652 PMC2601665__F1 Hh-Gli pathway and the Gli code in tissue patterning and stem-cell lineages 51684 2932 5972 8650 83737 6608 5727 PMC2610122__F1 Classical view of three independent Wnt signalling pathways 4920 387 324 847 51701 PMC2610366__F1 Pathways involved in folate-dependent methionine transmethylation and transsulfuration 4397 4524 875 PMC2635670__F1 Apoptosis pathways: The extrinsic or death receptor pathway (left) is triggered by members of the death receptor superfamily such as Fas 581 8772 637 PMC2643067__F1 De novo purine biosynthesis pathway 5631 7808 158 8833 PMC2648620__F2 Insights into the Roles of Gut Microbes in Obesity 114609 4615 54472 3725 6774 6347 3553 PMC2663527__F1 The formation of leukotrienes (LTs) through the 5-lipoxygenase pathway of arachidonic acid metabolism, and the effects of LT inhibitors in different contexts 1401 4049 4050 PMC2663816__F1 Single-Cell Profiling Reveals the Origin of Phenotypic Variability in Adipogenesis 6247 759 1674 PMC2669548__F1 Generalized schematic presentation of signaling pathways targeted by molecular therapies in malignant glioma 1956 5728 2475 PMC2671631__F1 The L-arginine biosynthetic pathway and its association to proline and polyamine biosynthesis 162417 55577 435 PMC2674698__F1 Structures and metabolic pathway of gangliosides () 410 2581 3073 2760 PMC2674702__F1 Metabolism of extracellular and intracellular bioactive lipids 4099 4018 717 PMC2676994__F1 Schematic model illustrating multiple signaling pathways in regulating StAR gene transcription 5617 1950 6667 PMC2679155__F1 Integrin-RTK signaling 5728 8440 3611 PMC2679770__F3 Proposed saxitoxin biosynthetic pathway 1636 412 717 PMC2681266__F1 NFKB activation in cancer 1956 4050 5970 PMC2682019__F9 A link between glucose and insulin signaling in Beta-cells 3479 2885 2308 2475 PMC2684140__F9 Schematic representation of the S 983 81532 59272 PMC2685579__F1 Synthetic pathways for polar lipids 780904 5091 283871 5662 PMC2685917__F9 Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells 3479 367 3480 1956 572 581 PMC2690394__F2 Molecular targets of natural chemopreventive agents 2885 5728 4193 PMC2693450__F3 Lipodystrophies: Disorders of adipose tissue biology 4018 978 7038 10555 PMC2696130__F3 Liquid Movement Across the Surface Epithelium of Large Airways 435 84890 1080 PMC2696130__F4 Liquid Movement Across the Surface Epithelium of Large Airways 84890 435 1080 PMC2697061__F2 Endoplasmic reticulum stress in disorders of myelinating cells 22926 83939 7494 468 PMC2702844__F2 Cell biology of autophagy in metazoans: a developing story 7248 7249 6009 596 PMC2704241__F5 Hepatic methionine metabolism and GSH synthesis 4397 635 875 PMC2707344__F4 Metabolic implication of leaf mitochondria during water stress 472 729 727 4118 PMC2715808__F8 Regulation of mTORC1 signaling by mTOR S1261 phosphorylation 6009 2475 64223 PMC2722219__F1 The TSC/mTOR signaling pathway 5728 4763 7249 7248 3667 6009 2475 PMC2732336__F1 Outline of the major cell surface receptor-mediated signaling pathways important in the differentiation, survival, and function of melanocytes 1000 5728 2932 1499 2475 572 PMC2734294__F3 Several molecular features in the cell body of an oxidatively stressed neuron 107966124 9817 1728 PMC2736107__F2 In addition to the hypothesis outlined in , a number of other mechanistic pathways could potentially lead to the formation of products 3-5 () 367 847 170302 PMC2737513__F1 IMP Dehydrogenase: Structure, Mechanism and Inhibition 158 2766 8833 PMC2741489__F5 Known components of the IFN signalling pathway and explanation of observed results 91464 5548 759 PMC2744278__F3 Phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways 2885 5728 4193 2475 2932 572 PMC2752022__F3 Akt-FoxO pathway in regulation of heart size 207 4280 7038 2475 PMC2756491__F8 PPARA/p16INK4a Pathway inhibits Vascular Smooth Muscle Cell Proliferation by repressing Cell Cycle-dependent Telomerase Activation 5465 1021 1019 7015 PMC2757186__F9 Working model for the biochemical cascade leading to the AR 4827 5864 4905 PMC2757940__F2 Major components of FGF and HH signaling pathways 10818 2885 6608 51684 PMC2760836__F2 New concepts in herpes simplex virus vaccine development: notes from the battlefield 5132 920 7097 4615 PMC2765277__F3 Scheme of part of the central metabolism of E 11113 4118 443 PMC2765277__F5 Amino acid producing elementary flux patterns 4118 2744 11113 434 PMC2765788__F6 STRIATAL NEUROPROTECTION WITH METHYLENE BLUE 246744 4151 1356 PMC2773711__F1 Canonical TCR signaling pathway 2534 3702 5966 2353 3725 3558 PMC2774072__F7 Proposed consequences of impaired insulin signaling in AD brain and in the STZ-injected rat brain 5728 2475 8473 10724 PMC2774487__F2 Pathway showing genes involved in Parkinson's disease (Courtesy: KEGG pathway) 6622 7054 27429 842 PMC2781329__F4 Schematic diagram for HO-1 modulation of signaling pathway and adiponectin, EET levels, and vascular function 51094 79602 5163 PMC2788159__F2 Current proposed mechanisms of amino acid sensing by mTORC1 Amino acids are imported into the cells via various amino acid transporters and activate mTORC1 either by amino acid metabolites or by undefined membrane/intracellular amino acid sensor(s) 7249 7248 6009 PMC2788936__F3 Signaling and regulation of PRR-induced autophagy 7099 4615 3606 PMC2790152__F3 A model of the inhibitor of growth (ING) 2 signaling pathway 5947 1869 3622 23411 PMC2801289__F1 UDP-galactose synthesis in L 101448070 2592 2582 PMC2805916__F1 Galectins, integrins and cell migration 8751 387 6667 PMC2817017__F2 RAS-RAF-MEK-ERK signaling pathway 2885 9846 5771 PMC2820199__F4 Curcumin’s targets intracellular components implicated in cell proliferation signaling pathway in prostate cancer cells 1956 1017 2475 PMC2840099__F7 Proposed model of miR-486 regulation and function in muscle cells 6722 5728 2932 PMC2841057__F1 Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension 367 545 7808 3667 PMC2841057__F4 Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension 545 3667 5163 PMC2852570__F1 Semaphorin signaling 51466 2932 6010 PMC2854204__F1 TOR-dependent control of autophagy: biting the hand that feeds 664 7248 7249 6009 PMC2857022__F7 Mechanistic model of KLF11-mediated tumor suppression and its antagonism by an oncogenic pathway 1956 5163 25942 8462 PMC2857169__F5 NFKB in conventional T-cell activation 324 3567 920 PMC2858440__F5 Four flux sensors of the in silico cell 5805 2191 3492 1401 1384 PMC2858867__F1 ALPS – Ten Lessons from an International Workshop on a Genetic Disease of Apoptosis 8772 841 843 PMC2864663__F4 Aging-related upregulation of AP-1 signaling in VSMC 2353 3725 5111 PMC2866836__F1 Mitochondrial Ca2+ channels/transporters and role in mitochondrial function 847 90550 1630 PMC2872188__F2 Generalized depiction of the energy cost of neurovascular coupling and its impact on astrocytic glucose utilization (CMRglc) 9373 84890 717 PMC2877979__F8 Schematic representation of some pathways and networks modified during strain improvement program according to results obtained after proteome comparison of NRRL 1951, Wis 54-1255, and AS-P-78 strains 4434 875 1431 PMC2878914__F1 Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway 10682 1499 7421 PMC2879321__F1 Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis 1956 6714 4615 2885 339855 1958 PMC2882741__F1 Schematic view of the GSL metabolism pathways 2717 2581 6611 283459 PMC2885902__F2 Mitochondrial biochemical pathways that are involved in KATP-independent GSIS 355 4199 5091 23152 PMC2886153__F1 Schematic representation of the intracellular cholesterol transport pathway 4864 10577 22937 PMC2888584__F7 Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1A in Melanoma Cells 3611 2475 7422 PMC2895628__F5 Mode of miRNAs that regulate adipogenesis by modulating the canonical Wnt/Beta-catenin signaling pathway 4041 4040 324 PMC2898443__F1 The eukaryotic 80 S initiation pathway 1999 1998 7458 1975 2001 1983 9669 PMC2899872__F1 Sequence Comparison Suggests a Role for TTL in Allantoin Biosynthesis.(A) Alignment of TTL with Urad and Urah protein from zebrafish 150465 391051 646625 PMC2905064__F2 Integration of oncogenic and tumor suppressor inputs by the GLI code in cancer 5728 5727 442900 5972 8650 3725 4193 PMC2905744__F3 Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors 5728 572 2475 PMC2911128__F1 PI3K/Akt/mTOR signaling pathway 4193 572 2475 64798 6009 1977 PMC2913986__F6 Gene Chip analysis reveal SOX11-induced regulation of Rb-E2F and TGFB signaling pathways 367 23118 10454 PMC2917385__F1 Tumor Microenvironment in Non-Small Cell Lung Cancer 1956 5728 2475 PMC2919366__F4 STAT3 signaling pathway 6774 9021 3458 PMC2921274__F4 Eph receptors and ephrins in cancer: bidirectional signaling and beyond 3932 2534 5728 387 PMC2923204__F2 Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease 627 2475 23237 PMC2923369__F2 Auto-layout of ‘Caffeine (C) neighborhood’ based on Ingenuity curated finding (IPA, Ingenuity® Systems) 1392 3952 4852 PMC2925528__F1 Summary of the systemic involvement of choline-containing species and their potential relationship with inflammatory processes 5091 4049 5228 6955 PMC2926749__F4 Proposed model for MALT1 function in NFKB activation 613 8915 10892 7189 PMC2929918__F1 Homocysteine metabolism in the liver 4397 635 4524 875 PMC2930805__F1 Metabolic signaling pathway of candidate pathway 3667 7249 7248 2475 5728 PMC2932466__F3 Signal transduction mechanisms involved in the mediation of cellular responses induced by secreted MIC-1 cytokine in certain cancer cells 1956 4089 387 PMC2937064__F4 Reactive oxygen species, UV light or other genotoxic stresses, that induce DNA damage, principally, double-stranded breaks, is detected by the MRE11-RAD50-NBS1 complex, which in turn activates ATM 472 3486 3479 940 7508 2475 581 PMC2938100__F4 Connections of literature-completed interactome of PI3K-mTOR pathway with other signaling pathways 3479 6010 2475 PMC2938150__F3 Comparison of fluxes of central carbon metabolism determined by MFA and predicted from a genome-scale metabolic model 7083 7084 2597 5183 1431 PMC2938197__F1 Predicted hydroxy/hydroperoxy wybutosine biosynthesis pathway and domain architecture of key enzymes involved in its synthesis 100187761 127253 55253 84890 PMC2943291__F6 Proposed scheme of the molecular mechanism underlying LPCAT2 activation 7099 4615 54947 PMC2948187__F1 Altered cellular pathways and processes in tumours 6010 5901 867 8213 1956 2475 5371 PMC2949025__F2 Correlations (Spearman) of biomass growth (biom) and lignin levels with transcript abundance of specific monolignol biosynthetic genes in a interspecific pseudo-backcross pedigree of Populus (family 52-124) 100188835 1312 790 PMC2949129__F7 Putative signaling pathways leading to translational activation and enhanced MCT2 protein synthesis after BDNF treatment in cultured cortical neurons 627 2475 1977 PMC2950451__F3 Metabolic flux distribution through branching areas of the central metabolism of MG1655 and ECOM4LA cell lines 2695 4118 11113 PMC2958907__F1 Web-accessible DC pathway navigator 114609 6101 367 7186 23586 6955 PMC2963103__F1 Normal biology of the VHL-HIF axis in the setting of (A) normoxia and (B) hypoxia 7428 2475 2056 664 7039 1956 9261 7867 PMC2988877__F2 DNA Damage Response: Making it safe to play with knives 472 641 545 PMC2990064__F4 Modeling Dose-response at Low Dose: A Systems Biology Approach for Ionization Radiation 581 596 995 PMC2990979__F1 Portions of the pathway utilized in Beta-branching are highlighted with color in this depiction of the bryostatin biosynthetic pathway 85451 730 95 PMC2997002__F2 Gene list involved in TLR pathway generated by KEGG 54472 4609 8205 PMC2997522__F2 Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies 6608 920 7852 PMC2998162__F2 Schematics of the Hippo pathway in flies and mice 351 23513 11081 PMC2999286__F1 The involvement of the Unfolded Protein Response (UPR) signaling in lipid metabolism 22926 83939 7494 7038 PMC2999931__F2 Postsqualene cholesterol synthetic pathway 3930 51478 10682 6309 1717 1718 PMC3001241__F1 MHC class II antigen processing pathways containing P 1508 920 4261 PMC3013016__F8 The molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling 7248 7249 6009 1977 PMC3017607__F2 The kinetic framework for programmed –1 ribosomal frameshifting 2056 4553 5447 PMC3018162__F1 Schematic and mathematical representations of the main model assumptions 2548 6476 3550 PMC3022184__F2 A proposed mechanism of TGFA/EGFR/ras-MAPK activation loop in HNSCC 7039 1956 867 PMC3023586__F1 Host-cell signalling induced by EPEC Tir 2534 7006 100124696 5879 PMC3031055__F3 TFM-C-induced alteration to IL-12p40 chaperone interactions 2922 64714 23071 79139 PMC3033158__F3 Signal pathways in systemic regulation of hepcidin 9518 7018 57817 3077 7036 PMC3033602__F1 Adapted from KEGG colorectal cancer pathway [, , ] 324 4087 51199 4089 581 387569 842 2353 PMC3033967__F8 Structural Characterization of the Polar Lipids of Clostridium novyi NT. Further Evidence for a Novel Anaerobic Biosynthetic Pathway to Plasmalogens 5662 780904 283871 716 PMC3035994__F1 Simplified model of nutrient signaling pathways influencing metabolic responses 5728 6009 7249 7248 PMC3038050__F1 Mechanisms by which CD44 can modulate cell death 960 355 8772 2475 11319 PMC3038089__F2 Biological consequences of methylation on Rho-RhoGDI interaction 23463 6010 23440 PMC3043627__F1 Simplified model for the intersection of signaling pathways regulating protein synthesis and degradation 2932 2475 1977 PMC3043796__F1 Signaling pathways activated by endothelin-1 (ET-1) in vascular smooth muscle cells (VSMC) 6714 387 6010 759 PMC3043796__F3 Proteins of signaling pathways activated by ET-1 are targets for O-GlcNAc 759 6714 387 6010 PMC3049195__F1 Proposed diphthamide biosynthesis pathway 51611 1802 285381 1801 PMC3055447__F4 A schematic diagram of pyramidal cells (triangular) and GABAergic interneurons (square) within the trisynaptic pathway of the hippocampus 759 5411 100379198 25801 PMC3056121__F1 Regulatory natural autoantibodies to apoptotic cells: Pallbearers and protectors 54106 51284 5091 49 PMC3060584__F6 ‘Integrative Physiology 2.0’: integration of systems biology into physiology and its application to cardiovascular homeostasis 259 759 8685 PMC3065471__F3 Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map 4094 2512 7314 847 907 8473 PMC3066060__F2 Simplified schematic representation of the apoptosis pathway in mammals and Drosophila 581 56616 355 8772 PMC3068086__F7 Schematic overview of the network of enriched pathways related to HIV disease progression 581 572 836 PMC3076281__F3 Effect of sphingolipids on the PI3K/AKT pathway 5728 2475 4193 842 572 PMC3076854__F2 Global transcriptome analysis reveals CB1R-dependent, PHX-induced up-regulation of key cell-cycle proteins 1950 1311 100187761 23300 6955 PMC3077220__F1 Hepatitis C Virus NS2 Protein Triggers Endoplasmic Reticulum Stress and Suppresses its Own Viral Replication 22926 7494 83939 PMC3088084__F4 Therapeutic effects can be monitored using DMR on scant cell populations 1956 2885 5163 4827 2475 PMC309045__F1 CRP-dependent (A) and CcpA-dependent (B) carbon catabolite repression pathways and the Ntr regulatory pathway (C) 1401 3250 3240 PMC3098789__F6 Portion of the 'Toll-like Receptor Signaling' pathway for two representative cell lines 8772 54106 100187761 841 PMC3110186__F5 Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology 7124 3553 3586 3458 4615 5966 6041 5640 PMC3131135__F2 Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection 1283 57506 3661 PMC3133259__F1 The CoA biosynthetic pathway 79717 60490 5471 PMC3136877__F1 mTOR signaling cascade in the pathogenesis and prevention of skin cancer 5728 7249 7248 6009 4193 PMC3138369__F1 Signaling pathway for epidermal growth factor receptor (EGFR) 2885 5728 2475 1956 22944 6651 PMC3138675__F2 Molecular mechanisms in hereditary cancer 324 1499 4193 5728 2475 PMC3141633__F3 Genes identified in the TGF beta pathway 2444 3458 4050 5478 10468 PMC3142627__F1 Procession to Pediatric Bacteremia and Sepsis: A Series of Covert Operations and Failures in Diplomacy 4049 10392 64127 920 1378 324 PMC3145575__F3 CSR pathways for primary non-HCC hepatocytes and HCC (Huh7) cell types 9118 7039 28755 1611 51701 2475 6955 4397 3458 PMC3148577__F1 Metabolic networks of Corynebacterim glutamicum (a) and Brassica napus (b) corresponding to the experimental fluxes measured by and respectively 64853 4118 7408 7414 11113 PMC3149098__F6 GProX Pathway Analysis of the Cellular Response to EGF Stimulation 4162 367 685 7975 8544 PMC3160333__F2 One Carbon Metabolism in SAR11 Pelagic Marine Bacteria 635 29958 1757 PMC3162038__F2 Biosynthetic pathway to validamycin A and characterization of VldB, VldE, and VldH 4149 4827 4860 PMC316360__F6 Interphase/S phase omission between the two meiotic divisions 4661 4342 7465 PMC3165799__F1 Schematic diagram of the ER stress response 22926 7248 6009 83939 468 PMC3170890__F1 IL-10 signal transduction and hypothesized treatment by dual gene therapy 6774 5163 6418 PMC3171509__F1 This figure illustrates the core TSC-mTor pathway, as discussed in the text 7249 5728 7248 2475 PMC3181220__F3 Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma 5728 7249 7248 6009 1977 PMC3189824__F2 Schematic model for the activation of NFKB signaling pathways 4055 958 5966 5971 5805 PMC3191034__F7 Postulated model for GRTH negative autocrine molecular mechanism of regulation of androgen synthesis in Leydig cells 6770 3156 367 PMC3192838__F7 Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response 57506 7187 7706 9636 83939 PMC3193404__F1 NFKB signaling pathways initiated by TLR4, TCR, TNF receptor 1, CD40 and genotoxic stress 958 7099 7186 472 9419 PMC3193406__F1 Canonical and non-canonical NFKB signaling pathways 958 4055 613 5971 5970 PMC3196210__F2 Relationships of different neurons in the striatum and neurotransmitter signaling involved in interval timing 2821 4666 627 2638 PMC3202988__F1 Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells 7523 10724 8473 PMC3203219__F1 Costimulatory pathways relevant in transplantation 940 958 324 29851 970 151888 PMC3203691__F3 CXCL10/IP-10 in Infectious Diseases Pathogenesis and Potential Therapeutic Implications 4283 920 3458 3383 PMC3206202__F10 Expression Profiling Reveals Differential Gene Induction Underlying Specific and Non-Specific Memory for Pheromones in Mice 51083 2548 8178 PMC3207473__F7 Model: TTP transition from “hypo- to hypermodified” determines its functional switch 2597 8717 8772 7186 PMC3209670__F3 mTOR signaling pathway affected by pollen feeding or varroa parasitism 253260 2000 7248 6009 673 PMC3210925__F5a Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis 283871 3250 183 PMC321741__F1 Signaling pathways for TLR-3 and TLR-4 7098 7099 3661 PMC3225910__F1 Signaling network connecting Rheb and AMPK 6009 7248 5728 PMC3227927__F1 Signaling pathways and effects of EGFR 7039 1839 1950 1956 5728 PMC3233056__F7 Different expressed proteins indicated in glycolysis, TCA cycle, pentose phosphate pathway, nucleotide metabolism, amino acid metabolism, and cell wall development 5805 50863 11113 PMC3234494__F3 Cytosolic RNA sensors 64127 3661 3665 PMC3236571__F7 Resistance mechanisms in the TRAIL signaling pathway 1637 8772 581 596 PMC3237908__F4 Schematic diagram shows the possible effect of xanthones on the apoptosis pathways 8772 581 637 2021 PMC3243350__F1 Biosynthetic pathway of oxylipins in Arabidopsis 1636 1690 11319 PMC3248275__F7 Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice 3479 3480 3667 2885 595 PMC3252978__F7 Summary of the results presented in this study 5879 387 10266 PMC3254042__F7 Signaling pathways involved in synaptic plasticity and neuroglia functions with associated molecules and cellular tasks (analysis based on Ingenuity IPA software) 1950 2885 673 5728 2475 4193 PMC3260274__F5 Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer 27250 5728 920 PMC3262099__F8 The host cell EGF signaling pathway and proteins downstream of the EGF receptor that are activated in response to C 1956 6714 5879 PMC3265821__F1 Change in RAF isoform usage in response to a RAS mutation 2885 673 4286 PMC3268503__F6 The Chl branch.The first step of the Chl branch is the insertion of Mg2+ into Proto IX 4255 5447 1690 27159 PMC3269020__F1 Pathways involved in aging 10229 3479 3480 5728 6416 4899 PMC3272847__F2 E6-mediated survival signaling 1956 2475 4193 PMC3276397__F1 Effects of VitA in gut-associated lymphoid tissue 5914 50943 7097 10333 2592 PMC3283604__F6 TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice 3575 2475 7249 7248 PMC3284544__F6 Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis 3665 338376 57506 10010 85451 5979 3661 9636 PMC3289121__F5 IPA illustrating the predicted effect of milk removal on PI3K signaling in T lymphocytes 640 5728 1611 100187761 PMC3292920__F1 Diagram shows the enzyme points (in cycle) on which the effects of n-3 PUFA might operate in the homocysteine metabolic pathway of relevance 4548 635 5212 4524 875 PMC3296744__F11 Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development 3716 7297 8554 10401 PMC3306981__F1 Summarized the signaling mechanisms of various matricellular proteins contributing to cancer progression 6678 3371 3611 6010 51176 PMC3310485__F4 Schematic of the role of BDNF in the brain reward pathway associated with addiction 7054 627 6957 PMC3314478__F1 Parkinson’s disease: don’t mess with calcium 7220 6786 468 2475 PMC3325001__F1 Hh signaling pathway 5727 6608 2735 51684 PMC3343154__F3 Mammalian unfolded protein response (UPR) pathways 7494 468 7186 83939 22926 PMC3345303__F2 Neural and Cellular Mechanisms of Fear and Extinction Memory Formation 5315 627 23237 2475 PMC3355838__F2 Genetic events involved in thyroid tumor initiation and progression 7253 673 5728 PMC3361414__F5 Schematic representation of the interplay of T7 gp5.5, gp3, E 51206 6741 4553 2814 PMC3362516__F1 Mitochondrial Ca2+ influx and efflux mechanisms 90550 3954 9927 10367 PMC3363007__F6 The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection 351 3553 367 PMC3366885__F1 Signaling pathways involved in head and neck cancer 1956 2064 2065 6774 2885 5163 572 6667 4609 7018 6418 PMC3369817__F8 Pathway diagram of the cyanobacterial core metabolic network 2821 7086 6120 2597 5183 1431 11113 4118 PMC3372318__F3 The two major signaling cascades operating in cancer, following overactivation of the INSR/IGF-IR signaling pathways 3643 6009 2475 PMC3375400__F1 Comparison of the pathways responsible for the anti-apoptotic and pro-apoptotic effects of immune complexes containing oxidized LDL (oxLDL-IC) and malondialdehyde-modified LDL (MDA-LDL-IC) 6850 572 948 7097 PMC3377006__F1 Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression 50943 920 8205 PMC3381238__F1 Schematic representation of APP processing and role of its products in AD pathology 351 9968 43 PMC338271__F1 HDL enhances NO production by eNOS in vascular endothelium 335 6714 338 PMC33831__F1 The branch of the flavonoid pathway for the synthesis of flavones in maize 717 7911 3240 PMC3385714__F3 Paralvinella conceptual glutathione pathway and responses to thermal exposure 5064 191 875 4553 2936 PMC3394800__F4 Developmental Changes in the Metabolic Network of Snapdragon Flowers 2539 2597 6120 PMC3394800__F7 Developmental Changes in the Metabolic Network of Snapdragon Flowers 3423 1431 5723 PMC3405863__F4 EGFR pathway in Drosophila 6770 1956 2885 PMC3406727__F1 Simplified schematic drawing of metabolic pathways in Chlamydomonas reinhardtii (adapted from Ref 729 727 718 717 PMC3406917__F3 Schematic Diagram of Matrix Protein Import into Peroxisomes.Cytosolic PEX5 and PEX7 recognize their cargo proteins (square and round shapes) via binding of specific targeting sequences, PTS1 and PTS2, respectively 5191 5189 5190 5830 PMC3407640__F8 Summary of pathways with differentially expressed genes comparing sarcomas to MSC in the current study 6608 387 1499 1017 1019 PMC3410255__F1 Regulation of PTEN/PI3K/AKT pathway by microRNAs 5728 3479 27250 595 PMC3411810__F6 BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines 5728 5163 2932 PMC3423345__F2 Early Second Trimester Maternal Plasma Choline and Betaine Are Related to Measures of Early Cognitive Development in Term Infants 4397 55349 4524 875 1719 27232 PMC3423951__F1 The interplay between pituitary hormones and main signaling pathways of the IGF system in thyroid, adrenal and ovary cancers 2492 7253 3667 2885 2475 PMC3425078__F5 Effects of NO and nitrosative stress on apoptosis 355 637 317 PMC3430470__F5 The role of Monosaccharide Transport Proteins in carbohydrate assimilation, distribution, metabolism and homeostasis 718 51083 717 PMC3432498__F1 Activation of the IKK-NFKB pathway by radiotherapy and chemotherapy 472 7189 23118 PMC3448443__F2 Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease 7249 6009 5728 2475 PMC3462343__F7 Model depicting how chronic exposure to SAg could elicit an autoimmune disease 6295 613 324 PMC3462655__F2 The signaling pathways involved in T-cell activation 920 940 27040 4058 3932 1445 387 PMC3465335__F4 Temperature Dependent Proteomic Analysis of Thermotoga maritima 2821 5372 2597 PMC3467082__F1 Translation of glutamine codons in yeast 4553 2638 55075 PMC3470116__F6 Simplified schema of putative signaling pathways accountable for the differential responses of A549 (A) and SNB19 (B) cell lines to Hsp90 inhibition and IR 5728 1019 4193 983 PMC3470479__F1 The Genetics of Alcohol Dependence: Advancing Towards Systems-based Approaches 125 217 1571 PMC3474542__F2 Nongenomic and genomic estrogen signaling pathways 8205 1956 1839 7018 PMC3478427__F3 Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act 367 2885 5163 PMC3480720__F1 Innate immune signals during B 54106 64127 10392 3661 100 6772 114609 4615 PMC3481038__F2 Scheme demonstrating mechanisms used by natural compounds to drive changes in the epigenome 5111 5728 1312 1786 PMC3483025__F1 Metabolic pathway of tetrapyrrole biosynthesis in plants 2235 5498 130749 7389 7390 5447 PMC3488210__F3 Sub-network found among the genes in a differential expression experiment that compares FA patients to controls 6955 324 572 2475 9520 4602 2078 PMC3490581__F4 Illustration of fluxes in central carbon metabolism for metabolic phases II and III along the protein/ tradeoff 1356 1368 4118 PMC3491070__F3a Cancer Cell Metabolism: One Hallmark, Many Faces 5728 7428 4609 PMC3491835__F7 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia 2475 7249 6009 7248 PMC3491906__F1 Distinct signaling pathways of synaptic and extrasynaptic NMDAR in neuron fate 23235 627 467 10628 PMC3496044__F7 Sialic acid biosynthetic and degradative pathways 10020 140838 55907 PMC3499024__F2 Bone anabolism regulated by statins 6010 650 860 PMC3502766__F5 Proposed metabolic pathway for the degradation of VFA and TCE inferred from the metaproteomic data 5662 1674 1121 PMC3507808__F1 Metabolites and their metabolic pathway networks measured by the Arg/Thiol Redox Metabolomics Assay 11113 435 875 635 4397 PMC3509892__F1 Transcriptional Changes Associated with Lack of Lipid Synthesis in Parasitoids 2539 5091 1431 1737 355 6319 PMC3514612__F7 Synthesis of nitric oxide and transduction cascades 847 2002 627 23237 PMC3514733__F1 Chemotactic signaling pathway in sperm 2638 759 847 PMC3516782__F5 Metabolic pathway of mannan in R 100188864 10266 10267 PMC3520539__F1 Generalized overview of the regulation of apoptosis by sphingolipids 637 572 842 PMC3538647__F1 Metabolic map of the purine biosynthetic pathway 5814 5813 3258 PMC3541279__F5 Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury 4803 627 8567 4099 8772 6469 84894 6608 7186 105373085 84662 4915 387 1155 PMC3544293__F2 MTOR signaling pathway 1956 3667 5728 6794 2475 253260 7248 7249 6009 PMC3549305__F4 GLUTATHIONE SYNTHESIS 4397 635 875 PMC3556981__F5 Analysis of Central Metabolic Pathway Gene Expression with Compartmentalization Information.Heat maps in boxes indicate the expression of individual genes, and the chart plots indicate the aggregate expression levels of the pathway genes 100379198 2821 1431 4397 2271 PMC3561376__F6 Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways 8717 8772 7186 637 317 PMC3565254__F2 Pathways involved in endocrine resistance 1839 1956 6714 6667 PMC3565315__F2 Overview about currently tested Hedgehog pathway inhibitors and their mode of action 6608 6469 3549 50846 51684 374654 PMC3571329__F7 Proposed metabolic model for syntrophic growth of D 3939 5447 140821 PMC3582714__F1 Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function 7249 7248 253260 6009 4609 3091 2539 PMC3587995__F2 p53/p21/pRb/E2F and p16/pRb/E2F signaling pathway 4193 648 1019 PMC3593900__F5 Schematic illustrating how TNF acts via the Wnt pathway leading to the development of the myofibroblast phenotype 4087 4088 1499 324 4089 PMC3596655__F8 Proposed molecular mechanisms of the anti-inflammatory effects of allosteric SHIP1 activation 5266 5728 5163 695 PMC3604032__F1 PI3K/Akt/mTOR signaling in breast cancer 5728 3667 7249 7248 6009 2932 PMC3608642__F4 Multiple Single-Cell Genomes Provide Insight into Functions of Uncultured Deltaproteobacteria in the Human Oral Cavity 9760 5447 100187907 PMC3613096__F2 Signalling pathways involved in airway smooth muscle contraction 952 50507 387 PMC3613825__F8 Proposed model of regulation of pro-apoptotic signaling pathway by miR-128 3488 23411 4193 PMC3615879__F4 Action of 20-HETE.Notes: Mitogens and ligands of G-protein-coupled receptors activate PLA2 and induce release of arachidonic acid, which is converted by CYP4A/F to 20-HETE 1956 2885 6714 PMC3619548__F1 Schematic summary of the most common mutations found in melanoma patients 5728 673 1029 PMC3621754__F3 MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches 1956 2475 2261 6714 2885 PMC3624606__F1 Oncogenes and tumor suppressor modulate metabolic reprograming in cancer cells 5728 2539 2744 57103 4609 PMC3636756__F2 Two hypotheses for Gwl activation and mitotic entry 4661 7465 10776 PMC3637854__F2 Overview of UPR signaling 22926 83939 468 7494 PMC3639292__F3 Metabolic rewiring in melanoma engages more carbon than just glucose 26227 2875 355 2744 PMC3641604__F9 The innate immune antiviral response triggered by IFNB and TNFA in AECs 50506 23586 57506 29110 3661 3434 405753 7187 7189 PMC3642687__F1 Pathway of reversible protein modification reactions that involve NAD+ consumption 8505 28992 140733 PMC3649103__F1 Hepatic glucose metabolism 2308 3667 355 338 7038 PMC3650620__F4 Cross-talk between insulin and inflammatory signaling pathways 7124 7099 8717 6774 7186 3667 2475 114548 4282 PMC3653146__F1 Possible signal pathway activated by cathelicidin (LL-37) to inhibit cell proliferation in gastric cancer cells 9134 4090 4086 1017 PMC3655322__F4 Diagram showing some of the downstream elements of the proposed Hippo pathway 595 1019 2305 PMC3660250__F8 Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3B, Neurotrophin-3 and CREB Signaling 5340 3479 3481 3480 2932 PMC3662220__F1 Novel zebrafish model reveals a critical role for mapk in lymphangiogenesis 2885 7248 7249 PMC3666381__F1 Metabolism in totipotent stem cells 790 3939 5091 PMC3667869__F1 Resistance to EGFR targeted therapies 1956 558 5728 PMC3668058__F6 Schematic representation of interacting fatty acid metabolic pathways in wild-type, D1, and D1o3-3 leaves 8694 4018 5091 PMC3674867__F1 Plasminogen Activator Inhibitor-1: The Double Edged Sword in Apoptosis 7448 581 100187761 PMC3675586__F1 Sugar nucleotide biosynthetic pathways identified in the genome of P 4351 4350 101448070 2582 51083 PMC3686324__F3 Osteoporosis – a current view of pharmacological prevention and treatment 4040 4041 847 PMC3690688__F8 Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium 10008 1080 3784 PMC3705591__F2 Common signaling pathway for Toll/IL-1R (TIR) family members 90865 4615 3656 7189 PMC3706439__F2 Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae 1636 65057 4118 11113 PMC3717794__F1 Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway 5728 7248 6009 7249 PMC3721730__F2 TRAIL-mediated extrinsic pathway of apoptosis 8772 51564 637 PMC3724399__F1 PI3K/Akt/mTOR pathway 5728 7248 7249 6009 1977 PMC3726443__F6 Full Transcriptome Analysis of Early Dorsoventral Patterning in Zebrafish 4040 1499 7547 145258 4485 PMC3732602__F5 TGFB processing and uPA-uPAR-dependent activation 5340 5045 7939 107966124 PMC3733802__F2 Prioritizing Disease Candidate Proteins in Cardiomyopathy-Specific Protein-Protein Interaction Networks Based on “Guilt by Association” Analysis 1610 1756 5350 4634 4633 PMC3734838__F6 Schematic illustration delineating the role of the AKT/Foxo3a/Bim pathway in selenite-induced apoptosis of CRC cells 6714 5728 5163 PMC3734905__F2 Germline syndromes associated with the Ras signaling pathway.Schematic diagram showing the GM-CSF receptor spanning the phospholipid bilayer 3717 2885 867 4763 PMC3740364__F1 Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways 7706 57506 7189 7187 29110 3661 PMC3746496__F2 PKM2 activity is controlled by a tight regulatory network at the transcriptional, proteomic and metabolic level 1956 6774 3091 595 1499 2744 PMC3753498__F9 Schematic representation of methionine metabolism via methionine cycle and transsulfuration pathway showing cysteine as a precursor of GSH and hydrogen sulfide (H2S) 875 635 4397 PMC3756518__F1 Schematic of the simplified B-cell receptor (BCR) signaling pathway simulated in our Monte Carlo method 613 4067 5066 6850 PMC3767399__F4 The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp 7390 130749 7389 2235 PMC3769322__F3 Regulation of action cytoskeleton in LTLT-Ca MCF-7 cells 929 2768 10672 2534 6010 1398 7408 7414 PMC3773983__F2 Four major signaling pathways in the postsynaptic region of a neuron that combine to form a local signaling network 627 2885 5594 PMC3774329__F6 The interactions between Rho/Rho-kinase signaling and bone morphogenetic protein (BMP)/transforming growth factor (TGF)B signaling 6010 2695 5480 PMC3775648__F4 Major elements of the Rho signaling pathway 2041 393 387 PMC3782205__F2 Nephrin-adaptors complex 2534 7225 23607 PMC3785049__F3 Type I interferon induction is inhibited by paramyxovirus interferon-antagonist proteins at multiple stages 7098 7189 7187 7186 29110 3661 PMC3792371__F1 TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma 3565 1738 3702 2534 3932 7535 3458 7054 PMC3793056__F5 Predictive metabolic pathway of biosynthesis in M 4548 1611 412 PMC3794713__F1 Simplified overview of commonly mutated oncogenes, tumor suppressors, and pathways in endocrine cancer 5979 7428 4763 673 55654 4149 4609 PMC3794713__F2 mTOR and MAPK pathways 2885 5728 7249 7248 6009 PMC3798256__F1 Pathways involved in stem cell hemostasis via regulation of nutrient sensing 5728 7249 7248 23411 PMC3806458__F1 Scheme of the biochemical pathways leading to carotenoids and other terpenoids 3423 3652 727 PMC3807489__F8 Proposed metabolic models for syntrophic growth of D 140821 3939 5447 PMC3808116__F2 Schematic overview of multiple feedback loops in the PI3K pathway 5163 5728 3667 PMC3810612__F6 Schematic diagrams of midsagittal sections through (A) the rainbow trout and (B) rat brains to summarize the contributions and interactions of the serotonergic and corticotropin-releasing factor (CRF) systems in the regulation of food intake 1325 7349 181 23237 PMC3815682__F1 Comparison of typical mammalian cell citrate metabolism and the metabolic pathway for net citrate production 1431 4118 11113 PMC3815777__F2 Putative intracellular cascades activated by cyclic di‐nucleotides 114609 7297 7189 57506 3661 54106 51284 7098 PMC3815941__F3 Bacterial and host effector molecules with potential probiotic effects 4049 7097 54106 PMC3819728__F1 Unfolded protein response and its regulation on cell activities 22926 83939 4899 468 PMC3822531__F2 Regulation of Wnt/-catenin signalling pathway.(A) Wnt forms a ternary complex with Fz and Lrp5/6, which promotes stabilization of Beta-catenin, thereby activating the pathway 4041 4040 324 1499 PMC3825669__F4 KEGG “Parkinson’s disease” pathway relevant to NRF1 target genes 339855 6622 7054 120892 836 842 27429 PMC3829921__F1 Small GTPases as regulators of cell division 23011 11021 382 PMC3831179__F14 Pathway databases 1950 2885 6774 2353 3725 6722 PMC3836209__F1 Metabolism of adenosine 4860 100 367 PMC3836673__F1 Intracellular effects of estrogen are exerted through two main pathways, genomic and non-genomic 2885 6714 50964 7018 6667 PMC3837380__F7 The Potential of 11C-acetate PET for Monitoring the Fatty Acid Synthesis Pathway in Tumors 2194 367 2475 PMC3843373__F4 The PI3K pathway is the evolutionary conserved signalling pathway to ensure that growth and development is synchronised to the appropriate metabolic conditions: energy and substrate requiring processes only proceed when a ‘fed state’ is indicated 5728 2475 572 PMC3844930__F5 Mitophagy pathways 65018 6009 9927 664 4976 PMC3850498__F1 Inhibition of the mevalonate pathway to override chemoresistance and promote the immunogenic demise of cancer cells 387 3091 3606 283871 3652 PMC3852811__F1 Metabolic networks of longevity 3630 3479 5728 3091 PMC3855388__F4 CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis 7006 100124696 126669 2069 PMC3855406__F2 Signaling pathways of NFKB activation 958 8717 7189 8772 5662 4055 PMC3868899__F8 Nicotine’s effect on immunity via the A4 nAChR signaling pathway in T cells 920 114787 998 PMC3875822__F1 Metabolic model of C4 assimilation, rates of reaction, and net fluxes between and 4118 2717 4151 PMC3875828__F1 Asp and aromatic amino acid biosynthetic pathways in plants 374569 5539 867 4397 PMC3879631__F6 Model for potential roles of SIRT7 in ribosome biogenesis 51547 2475 4553 PMC3886269__F4 Inducible antioxidant defense regulated by Nrf2/Keap1 and the antioxidant response element 2937 57716 9817 PMC3897565__F1 Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells 3586 5335 3558 PMC3899973__F1 Canonical signaling of muscarinic receptors 1956 2534 6714 1950 PMC3901225__F2 Protein complexes and their connection with metabolism 5805 11201 4553 PMC3909012__F7 Cell Surface Area and Membrane Folding in Glioblastoma Cell Lines Differing in PTEN and p53 Status 5728 4193 2475 355 PMC3911027__F4 Metabolic potential of Acidilobus-like populations from YNP deduced from coding sequences obtained from metagenome assemblies 4118 8772 5447 3045 100187828 5132 PMC3912487__F1 The sphingolipid rheostat in AD context 3479 23621 8877 56848 3065 3066 PMC3917155__F4 Inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity 54826 2475 353 PMC3917357__F1 Functional properties of ion channels and transporters in tumour vascularization 7006 100124696 59341 PMC3917509__F1 The multiple roles of protein ubiquitylation 5111 353497 7189 3014 PMC3922145__F3 Differential expression of mTOR and HIF-1A pathways between leiomyoma, HLRCC and leiomyosarcoma 7249 7248 6009 2475 1958 PMC3924581__F1 AEG-1/MTDH/LYRIC promotes hepatocarcinogenesis 27044 3490 4318 1499 PMC3926427__F1 FGF/FGFR signaling pathway 1950 2885 2475 PMC3934644__F1 Regulation and effectors of the mTOR signaling pathway 572 1017 1977 PMC3942883__F1 Induction and clearance strategies 5728 4151 7008 PMC3945337__F1 Quantifying the Sources of the Essential Sugar Mannose♦ 4351 5373 101448070 PMC3948775__F9 Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat 175 2582 5566 26136 PMC3959597__F7 Cross talk between metformin, androgens, and IGF system and molecular mechanisms of metformin inhibitory effects 6714 367 2475 PMC3960720__F8 Q43L mutant of neuregulin 2B is a pan-ErbB receptor antagonist 9542 1956 2066 PMC3961794__F1 Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1 7099 4615 3661 6774 7297 3716 PMC3964957__F6 Pathway diagram customization is available via the web interface, and lets the user control many aspects of the pathway diagram 5624 2241 100187761 367 PMC3967167__F5 PI3K/Akt-mediated mTOR activation positively regulates protein synthesis 6009 2475 1977 PMC3976145__F1 Genes involved in the WNT signaling pathway 4040 4041 324 7008 PMC3978385__F3 NRAS mutant melanoma: biological behavior and future strategies for therapeutic management 2885 673 4286 PMC3978635__F2 mTOR-dependent pathways and inhibitors 5728 2475 7249 7248 PMC3984540__F6 S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment care mediated by Gi and Rac 1000 6010 4313 PMC3992846__F2 Production of biosynthetic precursors during glycolytic metabolism and their putative regulation during Xenopus tail appendage regeneration 6515 2821 2539 2597 PMC3996455__F1 Treg functional stability and its responsiveness to the microenvironment 6348 4615 2475 10273 50943 6774 7908 PMC3998523__F1 Sphingolipid pathway and subcellular localization of sphingolipid enzymes 101180900 6611 6497 1674 PMC4001781__F3 Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma 4893 369 673 5159 PMC4011666__F7 Calcineurin Signaling Regulates Neural Induction Through Antagonizing the BMP Pathway 4090 4086 4089 PMC4014746__F1 Canonical Wnt pathway ] 4041 10023 1499 324 595 6908 PMC4017002__F8 PPARB/D promotes HRAS-induced senescence by potentiating p-ERK and repressing p-AKT 10125 5170 3611 4193 PMC4017424__F4 Activation of IKK pathway 2885 5728 6714 2475 PMC4026305__F1 Nox NADPH Oxidases and the Endoplasmic Reticulum 22926 83939 50507 7494 468 PMC4029488__F1 Basic regulation mechanisms required in the process of a cell utilizing glucose and glycogen 1401 5426 3240 5805 3250 PMC4029488__F2 HFPN model of extended center metabolism pathway in E 2695 5426 5805 3250 283871 PMC4032125__F7 Molecular Evolution of the Yap/Yorkie Proto-Oncogene and Elucidation of Its Core Transcriptional Program 7018 474168 1869 7475 100529111 PMC4034110__F1 Mitochondrial and metabolic checkpoints of T-cell activation and apoptosis signals 952 5336 940 790 PMC4034436__F1 Effects of the HIF pathway on mesenchymal stem cells (MSCs) 7852 9242 860 PMC4037387__F2 JAK/STAT pathway dysregulation in tumors: A Drosophila perspective 23513 9055 1445 PMC4040939__F2 Wnt pathway, sclerostin, and DKK1; effects of monoclonal antibodies on bone.(a) Scl and DKK1 bind Wnt coreceptors LRP5/6 to inhibit Wnt binding and signaling to decrease bone formation 22943 4038 4041 4040 PMC4046645__F2 Overview of molecular pathways of oxidative stress and potential points of intervention in T cells in SLE 2475 50943 3558 PMC4048824__F2 Pathways for sulfide biogenesis and clearance 875 847 6007 PMC4050496__F2 Notch: Architect, Landscaper, and Guardian of the Intestine 1950 100188776 5045 PMC4052696__F7 Based on experimental data GDS3634, miR-205 expression effect on prostate cancer cell line, from NCBI public database browser, P value of 8 samples of Student's t-test, microarray data was applied as the link cost for predicted paths 2778 3728 50937 5580 7039 PMC4058638__F1 Core phosphatases of the PI 3-Kinase pathway 5728 23239 23035 PMC4058660__F2 PI3K signaling in neural aging and disease 367 2932 2475 PMC4064064__F3 MicroRNAs and Toll-like receptor signaling pathway in hepatitis B virus infection 7099 7098 51284 54106 4615 3654 7189 3661 PMC4069271__F1a Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (HIF-1B): Is It a Rare Exception? 7428 405 196 PMC4081601__F3 Proposed mechanisms of anticancer activity of digoxin 6714 367 1956 PMC4082763__F1 Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease 3652 6010 2678 PMC4082789__F1 Exploiting sulphur-carrier proteins from primary metabolism for 2-thiosugar biosynthesis 729 727 718 717 PMC4085981__F1 Positive feedback in cardioprotection: Can more mechanism lead to translation? 5091 5163 253260 6194 2475 PMC4086465__F1 NKT-cell subsets: Promoters and protectors in inflammatory liver disease 324 5132 355 PMC4092085__F2 Na+, K+-ATPase-mediated signal transduction 1956 2885 3550 PMC4094786__F4 Metabolic pathways for the production of the high-value products by using Z 3939 6391 3045 100187828 PMC4096159__F2 Emerging Role of Autophagy in Alcoholic Liver Disease 5728 7248 7249 6009 2475 PMC4098898__F2 Glutamate Metabolism and HIV-Associated Neurocognitive Disorders 7852 6772 5266 3603 PMC4102553__F4 Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment 4057 340075 239 PMC4102824__F1 Flow diagram of the monoamine neurotransmitter biosynthesis pathway 6697 7054 367 1312 1621 5409 4350 PMC4106326__F15 Model depicting how PPARB/D promotes H-RAS-induced cellular senescence, whereas ER stress attenuates H-RAS-induced cellular senescence 10125 5170 2475 3611 4193 PMC4107453__F8 Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation 23235 1020 7249 9867 PMC4108926__F2 Melanoma and integrated Breast cancer pathway landscape 355 472 26136 4199 PMC4110478__F1 Hypoxia inducible factor and VEGF link the HIF/VHL and PI3K/Akt/mTOR signaling pathways 5728 7428 2056 3939 133 PMC4116802__F2 Inflammation induces B cell activation 613 4615 6774 PMC4120774__F6 ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC 5163 5164 2475 PMC4123224__F6 Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis 7852 7097 7096 4615 PMC4125180__F8 Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis 5228 6714 6770 596 581 1588 PMC4126464__F10 Metabolic redistribution in Synechococcus sp 3652 11113 4118 PMC4128044__F1 MTOR pathway is a central regulator of cellular processes 64798 55615 6446 PMC4132766__F1 Metabolic pathways for PA production 7038 95 4018 5091 2475 PMC4132813__F8 Model depicting the role of the PP1A signaling pathway in coordinating the activation of BRD4 and P-TEFb for inducible gene expression 23476 10614 1025 PMC4133096__F2 Role of 53BP1 during the cell cycle 472 55183 672 PMC4142723__F2 SIRT6 as a master regulator of glucose metabolism 7018 51548 3725 PMC4143829__F1 Model expressing the distinct molecular pathways of ER transcription factors regulatory actions 1956 6714 7018 PMC4149353__F5 Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms 100187761 55803 4937 6844 PMC4156265__F5 Pathway analysis 4015 5228 5226 4050 5225 PMC4156720__F1 Cotargeting the PI3K/AKT and AR pathways in CRPC 367 5728 2289 2475 PMC4160635__F1 Genomic aberration of the proliferative and invasive pathways of glioma signalling 1950 5728 5879 PMC4160991__F1 Schematic diagrams of DA dynamics and signaling in (A) Drosophila cuticle, (B) Drosophila brain, and (C) mammalian brain 1312 15 1644 7054 PMC4161359__F1 Mechanisms of AR pathway activation in CRPC 367 1869 10499 PMC4163504__F1 Proposed molecular interaction between two neuropathologies such as major depressive disorder and Alzheimer’s disease 351 348 761 PMC4163877__F2 Integrated signaling networks and tumor cellular bioenergetics 14 7249 7248 2475 PMC4171726__F4 Endothelial versus cancer metabolism 2695 5209 7086 2597 2744 2731 PMC4191248__F6 Renal cell cancer pathway 2271 65057 6392 PMC4193161__F8 A simple model was constructed on the basis of transcriptome data 847 5995 2077 578 5091 PMC4196943__F5 Dissecting the Transcriptional Response to Elicitors in Vitis vinifera Cells 5183 5212 1431 412 PMC4199550__F3 Iron Necessity: The Secret of Wolbachia's Success? 210 7909 7390 7389 130749 PMC4204733__F3 Schematic diagrams of Wingless and Arm structure, and pathway relationships 607 7008 324 474168 PMC4209186__F9 Diabetes Recovery By Age-Dependent Conversion of Pancreatic D-Cells Into Insulin Producers 3397 6502 2308 4609 PMC4209417__F2 Insulin-like growth factor-I receptor signaling pathway 3667 5728 2885 2475 2002 572 5111 PMC4213374__F1 This figure illustrates some of the mechanisms by which CD40L can influence on different cell functions and the processes by which these altered cells can impact on host immunity in neoplastic diseases 7018 3558 941 940 PMC4229513__F3 Outline of the targeted therapies, which are currently available or under development for the treatment of hepatocellular carcinoma, and the molecular targets on which they are believed to act upon 1956 2932 1499 572 2475 PMC4233036__F2 Pathway analysis highlights opposing regulation of a DNA repair pathway in radioresistant versus radiosensitive cells 472 9656 3458 545 PMC4233289__F2 Proposed model for the regulation of mTOR signaling in conditions of overnutrition and the cardiorenal syndrome (CRS) 3479 2475 7249 7248 6009 PMC4246236__F1 Cholesterol metabolism, lipid rafts and cellular prion propagation 348 4864 3156 19 PMC4253418__F7 Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer 7473 6259 6714 2932 324 2475 1499 595 891 7018 PMC4256868__F7 Isoprenoid metabolism in photosynthetic plant cells and its relationship to photosynthesis, glycolysis, respiration, and photorespiration 718 1431 3652 727 PMC4258904__F2 Plasmacytoid dendritic cell as the Swiss army knife of the immune system: Molecular regulation of their multifaceted functions 406947 695 51284 54106 4615 7187 7189 941 958 942 3654 51135 3665 3663 4665 3902 PMC4263370__F6 SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies 4018 51094 79602 4099 5465 7099 PMC4263855__F3 Potential protective role of O-GlcNAcylation within the healthy brain, which may become deficient in the AD brain 351 8473 10724 PMC4267524__F8 Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer 9118 3065 5728 PMC4269192__F1 Type 3 deiodinase expression on Warburg phenotype 3091 3939 4601 PMC4271587__F3 Flux map for accession 3231 (13C-MFA) 3240 4118 11113 PMC4273979__F1 Pikromycin and methymycin biosynthetic pathway in Streptomyces venezuelae ATCC 15439 95 1674 4831 PMC4276148__F1 Regulation of miRNAs in NHL 4609 5728 7837 595 23411 331 723778 PMC4279367__F1 Under physiological conditions, ERK signaling is regulated by extracellular signals binding to receptor tyrosine kinases (RTKs) 4763 5728 2475 1019 5925 PMC4280507__F4 One carbon metabolism and the effects of alcohol (EtOH) and nutrition throughout the metabolical pathway 27232 1356 1719 4397 4548 4524 2937 PMC4280834__F2 Proposed biosynthetic pathway of diphthamide 51611 1801 1802 285381 92715 89978 PMC4281031__F3 PI3K-AKT-mTOR signalling pathway and associated hamartoma/overgrowth syndromes (PI3K subsumes PIK3CA and PIK3R2, AKT subsumes AKT1-3) 5728 7249 2475 PMC4281941__F10 miR-93-directed down-regulation of DAB2 defines a novel oncogenic pathway in lung cancer 10018 4092 57659 57379 121340 1869 26524 7422 1601 2152 5728 3696 94241 1026 PMC4282534__F5 Relationship of bm2 to the lignin biosynthetic pathway 4524 4548 1312 790 PMC4286601__F1 Main glucose degradation pathways in the heart 101448070 7086 2597 PMC4290680__F2 ManLAM and PIM action on phagosome maturation and autophagy 3458 2475 8408 51552 PMC4295378__F1 WNT signaling network 387 324 1499 51701 1401 PMC4298491__F2 PI3K in the biology of B cells 613 930 643 958 974 4067 6850 695 5336 2475 PMC4302918__F3 Metabolic crosstalk between key signaling pathways in stem cells via ROS and other metabolic co-factors 5728 2309 23411 7351 PMC4303468__F18 Generation and metabolism of H2S 875 847 4357 PMC4303633__F5 Metabolic scheme of ectoine, glutamate and proline synthesis and catabolism inferred from the Nitrosopumilus genomes 5091 1431 100379198 11319 5625 PMC4305955__F1 Fibronectin-related signaling pathway graph stored in HBVPathDB 6714 1445 6010 PMC4307032__F2 Signaling Molecules: Hydrogen Sulfide and Polysulfide 1610 847 875 PMC4310697__F4 Toll-like receptor (TLR), nucleotide-binding oligomerization domain (NOD)-like receptor (NLR), and retinoic acid-inducible gene (RIG-I)-like receptor (RLR) signaling 114609 4615 6850 7189 64170 3550 7187 3661 PMC4315934__F4 Cardiac muscle contraction and changes with exercise 3479 3082 2626 PMC4320971__F1 Sphingolipid metabolites in inflammatory disease 94103 6611 64781 PMC4322985__F1 BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications 1950 1956 5728 PMC4323349__F1 Transgenic Mouse Models for Alcohol Metabolism, Toxicity and Cancer 2729 2730 847 1571 217 PMC4325629__F2 Hedgehog signaling in cancer stem cells: a focus on hematological cancers 5727 6608 2735 595 PMC4326486__F4 Proposed model is that CD146 promotes angiogenesis and mesenchymal cell migration in melanoma 7474 1856 467 PMC4327875__F2 Accredited translational medicine centre: Human renal fibrotic disease: Translational research at the Center for Cell Biology and Cancer Research (CCBCR), Albany Medical College, Albany, NY 472 1956 7392 PMC4330468__F1 Molecular targets and associated therapies to block three immunosuppressive checkpoints in a malignant brain tumor (glioma) model 941 1493 324 940 PMC4357015__F1 Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi 780904 907 5091 5662 PMC4357208__F1 Metabolic network for flux analysis 7083 11113 4118 PMC4358122__F5 Reciprocal regulation of AMPK and PLD 7249 7248 6009 5337 PMC4359241__F3 Androgen receptors beyond prostate cancer: an old marker as a new target 2475 367 253260 PMC4364658__F1 MiRNA targeted signaling pathways in four different important cells including plaque macrophage, platelet, monocyte and endothelial cell 1956 4803 6010 324 6502 PMC4367433__F2 Pathway for protein modification by UFM1 51569 55325 79876 51506 23376 PMC4371597__F1 Evaluation of the Unfolded Protein Response: PI 3-Kinase Regulatory Subunits as Regulators of the IRE1A Pathway 22926 83939 468 PMC4374654__F3 Emerging regulators of the inflammatory process in osteoarthritis 22926 83939 7494 3553 PMC4378458__F4 NAD+biosynthetic pathways 23475 93100 10135 PMC4386978__F1 Extracellular signalling molecules in the ischaemic/reperfused heart – druggable and translatable for cardioprotection? 5225 6774 2932 PMC4389409__F2 Plant phytochemicals achieve hormesis through multifocal pathway inhibition 23411 5728 2475 PMC4390799__F1 For therapeutic modulation of the UPR 22926 83939 7494 468 PMC4393010__F12 Pathway regulation by CsrA 2695 7086 6120 2597 1431 11113 4118 4397 PMC4396490__F10 Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles 5027 3553 7018 PMC4399270__F4 Functions of Klotho 2308 1594 4303 100 PMC4408919__F3 Opposing effects of target overexpression reveal drug mechanisms 1725 2356 1719 PMC4412741__F1 Effect of Antibodies on Endothelium 7450 6010 6714 PMC4412741__F2 Effect of Antibodies on Endothelium 966 51083 6010 6714 253260 2475 PMC4427577__F1 Signaling by TGFB family members through the Smad-dependent and Smad-independent pathways: TGFB induces its response by multimerization of TGFB receptor II (TBRII) and TGFB receptor I (TBRI) 4088 4089 10454 PMC4437987__F1 Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors 1956 64223 6194 PMC4438218__F1 Proposed model for the regulatory role of methenyl-dH4MPT in methylotrophic metabolism in M 2645 3250 3240 PMC4443896__F1a Activation of the JAK/STAT pathway in Behcet’s Disease 2520 2885 2475 1051 PMC4461458__F2 Prevalent mutations in acute myeloid leukemia (AML) potentially affect HIF levels in cancer cells 2475 4193 3091 7428 PMC4465296__F3 Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer 6469 7046 7048 PMC4469999__F2 Complement cascades 717 727 8168 PMC4472073__F2 Mechanism of castrate-resistant prostate cancer.Notes: 1) Androgens bind and activate the AR despite the castration of testes-derived androgens 367 100187761 5901 PMC4479532__F3 Activation of a B-cell and its regulation by miR-155 613 4067 6850 PMC4479729__F1 The synthesis of glycoconjugates from glucose through the hexosamine biosynthetic pathway (HBP) 8473 7054 10724 51083 PMC4480706__F8 HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation 9734 1956 1017 PMC4484234__F1 Structures of schweinfurthin B and 3-deoxyschweinfurthin B (3dSB) 3652 2224 5906 PMC4485330__F1 Regulation of the interleukin (IL)–17 axis is essential for oral immunity and homeostasis 324 6774 6772 PMC4488003__F6 The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core 4151 581 2475 PMC4489880__F1 When pathways collide: collaboration and connivance among signaling proteins in development 4041 4040 1499 324 PMC4494900__F3 Emerging role of CaMKII in cancer 7074 995 1019 PMC4496101__F1 The extrinsic and intrinsic apoptotic pathway 8772 637 581 27429 2021 PMC4496218__F9 Pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis 5728 7412 3383 PMC4498564__F1 Heme biosynthetic pathway 2235 130749 210 9049 7390 PMC4498740__F2 Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells 1311 27040 100379198 PMC4498740__F3 Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells 27040 5970 759 PMC4508827__F7 Jak-Stat pathway of C 1017 5894 5163 1019 5728 8554 PMC4522091__F1 Simulation of metabolic flux changes in the central metabolism of the redox reaction manipulated strains 11113 197257 2597 PMC4522946__F6 Apoptotic signaling pathway induced by Licochalcone-A in head and neck squamous carcinoma FaDu cells 100187761 637 581 596 572 8772 PMC4532404__F8 Signaling pathway of regulation of actin cytoskeleton 3630 2147 51083 1793 324 6010 10152 5829 7414 2934 PMC4534795__F12 Selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression 4899 7054 100187761 717 1356 PMC4535771__F1 Using DeDaL for visualizing Fanconi pathway in breast cancer 641 100187761 8066 PMC4546523__F2 Biosynthesis of heparin/heparan sulfate and chondroitin sulfates 51083 2717 10090 1431 PMC4555184__F3 Stem cell mechanobiology: diverse lessons from bone marrow 4000 6722 6010 PMC4559511__F1 Complement cascade 718 717 727 PMC4561380__F6 Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw 100034703 2689 7086 PMC4564397__F1 HOCl signaling pathway A 27035 4025 847 PMC4568905__F5 2-Hydroxy Acids in Plant Metabolism 2597 4397 5183 PMC4571974__F9 TRAF6 regulation by arginine methylation 3276 7189 23210 11213 PMC4573837__F1 Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors 253260 2475 5163 1977 1975 PMC4576153__F1 Negative regulators take action at almost all steps of TLR signaling 4118 4615 7189 51135 8772 3656 7187 1540 3661 3665 PMC4587803__F3 NF KB signalling pathway 727 717 718 100187761 720 729 730 PMC4594188__F1A Significant signaling pathway networks in each group 4609 811 6667 5624 PMC4594238__F8 Sensory initiation of a co‐ordinated motor response: synaptic excitation underlying simple decision‐making 7263 7038 4151 PMC4595741__F3 Revisiting the chlorophyll biosynthesis pathway using genome scale metabolic model of Oryza sativa japonica 4118 11113 847 PMC4595979__F1 LOX pathway 4015 1674 1431 PMC4601184__F1 IGFR1, a possible target in tumor progression and metastasis 1956 1950 3479 7018 4313 4318 PMC4601220__F1 RNAi pathways in insects 29102 5901 192669 27161 26523 PMC4614032__F1 mTORC1 signaling pathway 7249 7248 6009 PMC4615225__F6 Overview of regulatory networks in which miRNA/target pairs function during the rice response to fungal elicitors 192670 26523 2077 PMC4617705__F4 Effects of CsA on the expression of genes involved in endoplasmic reticulum stress and FXR-regulated pathways in WT-PCLS and FXRKO-PCLS 2922 5764 65057 6955 338 100187761 31 PMC4632976__F1 The intracellular parasite Toxoplasma gondii depends on the synthesis of long chain and very long-chain unsaturated fatty acids not supplied by the host cell 6924 6923 6921 PMC4633353__F7 Constitutive control of AKT-1 gene expression by JUNB / CJUN in ALK+ anaplastic large cell lymphoma: a novel crosstalk mechanism 6714 2475 3726 3718 3725 6774 PMC4635569__F1 Proteins used in this study 3075 718 2271 PMC4637208__F2 Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts 4397 9317 5447 7374 PMC4643722__F3 Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases 351 8772 847 PMC4643792__F3 Dietary phytochemical alters caste-associated gene expression in honey bees 351 7791 474168 1956 PMC4648866__F1 Glycerol biosynthesis in respond to osmotic stress and redox statue and the interrelationship with yeast-derived aroma compounds in S 2820 2819 7167 PMC4652017__F2 Putative stress signaling pathway in wheat where functional genomics contribute 4602 7018 2077 PMC4661094__F1 RPE Necroptosis in Response to Oxidative Stress and in AMD 8717 8772 637 90427 PMC4664460__F3 Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain 7249 7248 1977 PMC4669103__F4 Role of Innate and Adaptive Immunity in Cardiac Injury and Repair 7097 7099 2534 4615 3661 920 PMC4673016__F1 Transcriptional and chromatin regulation during fasting – The genomic era 28999 10682 5465 7942 PMC4675703__F1 Therapeutic control of complement activation at the level of the central component C3 718 1431 717 PMC4682189__F2 Comparative transcriptome analysis of grapevine in response to copper stress 210 7390 1371 5498 7389 5447 PMC4682887__F1 Vaccines against Gonorrhea: Current status and Future Challenges 7054 920 2638 3553 PMC4684266__F1 Simplified scheme of sulfur metabolism with an emphasis on the H2S-generating reactions 4397 4524 875 847 PMC4700229__F1 Interactions between immunotherapy and targeted therapy 324 1956 2885 2475 PMC4702801__F1 Snapshot of Colorectal Cancer Atlas features 759 5763 27040 PMC4705527__F5 Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin 3652 11113 4118 PMC4706689__F2 IL-10 Anti-inflammatory Signaling Pathway is enriched for putative differentially expressed genes (Progressors vs NonProgressors Enrichment False Discovery Rate adjusted P-value = 0.0287) Figure is a stylized representation of the Biocarta pathway 3587 7124 6777 6775 644 645 PMC4711038__F5 Altered gene expression in the JAK/STAT signaling pathway during diapause 8498 51247 10528 PMC4728678__F2 Lipid rafts as platforms for cell signaling 7852 6714 8772 PMC4733614__F1 Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies 613 6850 4772 10379 PMC4735514__F2 Activation of the methylation cycle in cells reprogrammed into a stem cell-like state 635 10400 4397 4524 875 1491 PMC4736209__F2 Schematic illustration of an inflammatory IDO activation by LPS and inflammatory cytokines and possible regulatory mechanisms on transcriptional, posttranscriptional, and posttranslational level 27040 9021 274 PMC4740345__F3 Sirolimus and CNI impact on insulin signaling pathway 7528 3667 5163 PMC4743853__F6 Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells 2885 4312 3082 PMC4754450__F1 Abbreviated pathway for the biosynthesis and metabolism of Orn in plants in connection to polyamines, amino acids, TCA cycle metabolites, and alkaloids 162417 55577 5625 4942 1610 5009 PMC4755536__F7 De Novo Transcriptome Assembly and Characterization for the Widespread and Stress-Tolerant Conifer Platycladus orientalis 1999 574414 80742 PMC4764103__F1 The CoA biosynthetic pathway 79717 60490 5471 PMC4765995__F1 Polyp to colorectal cancer sequences 3845 6608 51199 4397 4975 PMC4766428__F2 Bacterial cellulose synthesis mechanism of facultative anaerobe Enterobacter sp. FY-07 2597 355 5132 23440 PMC4768675__F6 RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity 2033 11317 171558 1636 100 PMC4773443__F5 Metabolic intermediates regulate Yersinia virulence 3250 1401 5970 PMC4774966__F5 Tolerant and Susceptible Sesame Genotypes Reveal Waterlogging Stress Response Patterns 5480 2020 100187761 11319 390937 PMC4775111__F10 Scheme and coexpression network for a putative flavonol synthesis pathway in tobacco flowers 847 367 2096 PMC4776187__F3 Modes of action of lipids in enterovirus replication 11337 7248 6009 2475 PMC4778854__F3 Changes in the expression levels of genes associated with cell cycle pathway in PC3 cell line after treatment with G 5591 10744 324 894 10278 9759 PMC4784227__F4 Heme biosynthesis pathway 7390 7389 130749 PMC4789259__F1 Canonical miRNA biogenesis pathway 54487 29102 1653 5901 PMC4792934__F10 Proposed store-operated signaling mechanisms in end-feet of Müller glia 4666 6786 7220 PMC4796178__F1 Exercise-induced autophagy signaling 7942 7018 23411 2475 664 PMC4800863__F5 Schematic illustrations of l- and d-proline metabolism in Sinorhizobium meliloti 5624 8039 389333 PMC4809647__F3 Highly heterogeneous, activated and short-lived regulatory T cells during chronic filarial infection 27040 1493 6351 3586 116984 PMC4812151__F2 Signaling pathway and biological function of Rap2B, a Ras family small guanosine 5′-triphosphate-binding protein 2695 5912 10235 9448 23043 PMC4815022__F4 Identified signaling pathways downstream to glycine in NSCs 11197 654 64399 7048 7157 9630 1026 27244 83667 143686 4842 3708 814 841 55729 6469 PMC4819324__F1 Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis 3652 2224 5906 PMC4820400__F2 Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease 1636 3416 4318 23621 PMC4831565__F4 GAPDH nitrosylation pathway mediates cocaine effects 2597 6477 6839 PMC4836208__F3 Targeting aberrant HH-GLI pathway 6608 51684 2736 PMC4836414__F1 The butanone biosynthetic pathway 465 3250 5805 3939 717 84890 PMC4837277__F1 Involvement of ROS in regulating M1 responsible phagocytic activity and inflammatory response 51295 7189 3606 PMC4839264__F7 mTOR signaling in ALK+ ALCL oncogenesis 238 2475 5163 253260 6194 1977 PMC4843955__F1 Signalling and muscle proteins synthesis (MPS) responses induced by amino acids (AAs) and different contraction intensities 2475 1977 1938 PMC4844615__F3 Pathogens-induced TLR signaling cascade in innate immune cells may exacerbate autoimmune diseases 7099 7097 4615 114609 51135 7189 3603 2353 PMC4850081__F23 Central Metabolism probed by hyperpolarized 13C enriched precursors 4118 2744 2271 1674 PMC4857091__F6 Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome 51119 2475 3692 PMC4858120__F5 EGFR, HER‐2 and ER with downstream the RAS/RAF/MAPK and PI3K/AKT pathway 1956 3845 673 5728 2475 PMC4868481__F7 Both the EMP (red) and the OPP (blue) pathways share intermediates with the Calvin–Benson cycle (circled in red), but not the ED (green) pathway 6120 7086 1896 2597 PMC4870238__F1 Signal transduction pathways that mediate Treg resistance converge on the PI3K/Akt pathway 7124 7097 54106 7096 7099 51311 7185 7186 7187 7188 6774 6778 4615 940 7189 PMC4874354__F8 Glycolysis 2821 2597 3240 PMC4889059__F2 Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype 79068 5091 1071 2475 PMC4898659__F3 Signalling pathways modulated by NF1 4763 7249 7248 6009 2475 PMC4904104__F5 Disturbed metabolic pathway related to NAFLD and HD-TE treatment 4018 5091 10400 7038 9791 1071 3931 5662 PMC4905267__F1 Common vesicular trafficking module in the assembly of the immune synapse and the primary cilium 324 9341 90410 6608 PMC4914454__F5 “The Expanding GRK Interactome: Implications in Cardiovascular Disease and Potential for Therapeutic Development” 761 10014 2869 PMC4919564__F2 Representative signaling in the AMPK pathway by various AMPK activators 51094 79602 2475 23411 PMC4923873__F1 Plasma proteomic analysis of stable coronary artery disease indicates impairment of reverse cholesterol pathway 790 6418 642658 PMC4928589__F2 Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective 64798 2475 2309 253260 8408 PMC4934657__F3 Fanconi Anemia Proteins, DNA Interstrand Crosslink Repair Pathways, and Cancer Therapy 545 29089 79728 7398 PMC4936107__F1 (Left) Model for sulfur assimilation 4397 2242 4553 875 867 PMC4939337__F3 Circadian Rhythm Signaling pathway 7432 6616 9575 551 8864 8863 PMC4943213__F1 Wnt signaling 324 2932 1499 PMC4948278__F5 EpCAM-palmitoylated claudin7 complex in pancreatic cancer stem cells 4072 960 2669 6714 3611 5728 PMC4949768__F1 Central carbon metabolism model for M 4118 11113 3250 PMC4964743__F3 Regulation of HER3 and downstream signaling 2885 4734 5728 9101 367 2475 406988 PMC4974519__F1 The induction of ER stress and UPR during coronavirus infection 22926 7494 83939 468 PMC4977886__F4 Differentially expressed proteins regulated cellular processes/diseases and hypothetical depiction of BPA action 4205 6390 60 8139 PMC4980531__F2 Multifaceted regulation of T cell responses by ROS 6774 940 355 6775 PMC4985489__F2 Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment 2475 9455 627 PMC4985808__F7 Transcriptomic analysis of heteromorphic stamens in Cassia biscapsularis L 7054 875 867 PMC4988489__F2 The piRNA Pathway: Guardian of the Genome –A Fly’s Perspective 4199 192669 175 PMC4991528__F3 Recommended decision pathway for UK patients considered for treatment with tolvaptan according to Renal Association guidance based on the NICE decision 1956 2271 140805 PMC4992866__F11 Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation 6194 5660 1984 PMC5000672__F6 Proposed signal pathway activated by HMDB in HeLa cervical cancer cells 1021 1017 1019 2475 PMC5000752__F6 Androgen receptor (AR) signaling pathway 367 2885 6714 PMC5000752__F7 Simplified representation of canonical and non-canonical Hedgehog(HH) signaling 51684 2737 5727 64399 6608 2736 2475 4088 4089 PMC5002299__F3 Regulation of the NLRP3 inflammasome activation by the ubiquitin-proteasome system 7187 7189 114548 79184 3603 PMC5003333__F1 Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms 4854 2022 3777 4089 PMC5003840__F1 Proposed biosynthetic pathway to the synthesis of xanthanolides 2548 1690 5805 PMC5008685__F4 CHOP-induced apoptosis under prolonged ER stress 83939 468 30001 1649 PMC5016702__F8 The signaling pathway by which FSH, via PKA, regulates the PI3K and ERK pathways in GCs 1956 3479 3667 PMC5019180__F2 Complement-mediated regulation of metabolism and basic cellular processes 718 727 716 721 10747 4179 940 1514 2475 596 PMC5020319__F3 De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin 5728 5266 3558 PMC5029616__F2 Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters 4193 7019 6667 PMC5037548__F4 Apoptosis signaling pathways induced by icariin and icariside II 581 8717 8772 637 PMC5038858__F3 The Notch pathway in ovarian (A) clear cell carcinoma ES2 and (B) serous carcinoma OVCAR3 cells following exposure to vorinostat 10763 23493 23462 100188776 4851 759 1431 PMC5047918__F2 Simplified view of B 5805 3939 3948 3945 PMC5053787__F1 Complement cascade 718 716 715 721 727 PMC5056018__F1 Estrogen Signaling Pathway 6714 7018 4609 7039 PMC5063375__F4 Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency 4282 7054 1312 PMC5063588__F9 How Thbs4 functions as an intracellular regulator of muscle cellular attachment and membrane stability 7060 22926 7038 PMC5070033__F1 Molecular signaling events of brain-derived neurotrophic factor-mitogen-activated protein kinase pathway and depression 627 10818 5697 2885 PMC5072418__F1 Proposed Pd0/PdII catalytic cycle for aryl fluorination 170302 367 64146 PMC5075711__F1 Formal modeling and analysis of ERA associated Biological Regulatory Network in breast cancer 3480 1956 3667 4193 672 PMC5079521__F1 Physiological mechanisms and therapeutic potential of bone mechanosensing 5311 5310 860 PMC5085760__F1 Major protein cascade and miRNAs in insulin signaling pathway 406913 768219 9927 PMC5088527__F2 Biosynthesis pathways of acetyl-CoA and NAD cofactors, and their involvement in chromatin-related processes 5212 10135 23411 PMC5089864__F1 Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network 51083 5236 55276 PMC5090835__F1 Anesthesia-induced pathways of neuronal apoptosis.Anesthesia induces apoptosis by seven different pathways 355 627 847 PMC5098802__F2 Injury site-specific targeting of complement inhibitors for treating stroke 5340 727 718 1401 1378 790 PMC5102139__F8 Pathway map of NOD-like receptor signaling in independent JU-RME 2242 64127 4671 PMC5115958__F2 Non-invasive metabolic imaging of brain tumors in the era of precision medicine 5163 27040 4609 PMC5118428__F7 K-state regulation in domesticated and undomesticated strains 1674 85457 8192 PMC5122694__F2 Canonical pathways by IPA: antigen presentation pathway in the NC vs 920 213 811 3458 PMC5124549__F1 Redox Biology and the Interface Between Bioenergetics, Autophagy and Circadian Control of Metabolism 55818 8473 7018 PMC5124731__F1 Production of aromatic compounds via shikimate pathway in microbes 6608 5539 5132 PMC5127716__F4 Immune signaling cascades triggered by Cryptococcus neoformans recognition 6850 64170 5336 114548 10892 3603 3553 8915 PMC5130114__F1 Disorders of the mTORC1 signaling pathway 5728 7249 7248 PMC5133582__F7 Metabolic pathways in hepatocellular carcinoma 65057 1636 6503 1611 85477 PMC5135332__F6 Reconstruction of purine biosynthetic pathway in C 5471 5198 7808 471 158 PMC5138043__F2 FAT4 participates in tumor transformation through the Hippo–Wnt signaling pathway by inducing YAP–TAZ activation.Notes: Src-mediated tumorigenesis also results from Src activation to repress FAT4 gene expression via MEK/ERK or cofilin1 6714 324 1499 79633 221937 PMC5138061__F1 Schematic representation of hypothesized cholesterol/phospholipid recycling mechanisms in the injured CNS 3949 7436 107966124 348 19 PMC5139139__F4 Linking identical processes found between two metabolic maps 11316 3460 3458 2022 3717 435 3659 PMC5141640__F3 Ischemic stroke induces systemic immunosuppression mediated by several factors 2638 7097 367 1813 PMC5143322__F1 AHR signaling pathway 5578 5728 214 3725 5970 1878 196 367 6955 PMC5150411__F1 Metabolic pathways expressed in the deep subsurface 6120 2645 4524 7086 790 2597 4548 5183 3045 100187828 3250 PMC5157899__F4 PEP-mediated metabolism in thermogenic cells of S 5183 10465 4118 PMC5166441__F1 Complement system 1401 2271 720 717 718 721 367 729 966 730 27202 735 PMC5173116__F7 Reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux 5091 2475 79629 PMC5173258__F1 Ivermectin induces cytostatic autophagy by blocking the PAK1-AKT axis in breast cancer cells 5058 2475 8678 22863 5289 PMC5187688__F5 TCA pathway 5183 1431 4200 4397 PMC5199628__F1 Principles of Kinase Inhibitor Therapy for Solid Tumors 3815 1956 238 5979 2475 PMC5206730__F7 Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial 7414 126669 2017 1398 1399 8315 PMC5206990__F3 Rationale for combination therapy in lymphoma 613 958 3717 3716 4067 6850 695 2475 974 973 PMC5213309__F5 Soluble tumor-derived signals change the phenotype of the tumor-associated macrophage, by induction of the mTOR pathway and glycolysis, and epigenetic changes 207 2475 5209 PMC5214458__F1 Schematic demonstrating the signaling networks and their cross talks involved in differentiating the mesenchymal stem cells (MSCs) into osteoblasts 4040 4041 6010 1499 860 6722 9242 PMC5216946__F13 Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer 3156 6667 3652 6010 PMC5217345__F3 Fibroblast growth factor 21 (FGF21) regulates Sirt 1-mediated release of adiponectin from adipose tissue with relevance to NAFLD and the metabolic syndrome 23411 10682 5225 23394 PMC5219787__F4 Hedgehog signaling pathway 5727 6608 51684 2932 PMC5223235__F3 Processing and presentation of MHC class I and II restricted antigens for CD8+ and CD4+ T cell recognition, respectively 920 567 324 PMC5223280__F5 Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptotic Pathway During Chemotherapy in Bone Marrow 2621 993 1017 1019 PMC5225216__F2 Hypothesis of intercellular energy relocation triggered by gut microbiota 5894 114609 4099 PMC523224__F6 Metabolic pathway leading to generation and detoxification of MG 7086 6120 4128 PMC523881__F1 The monolignol biosynthetic pathway 1312 65057 790 PMC524243__F1 Simplified model of insulin signaling 2885 6855 5163 5164 3484 PMC5256616__F4 RGS6 in central nervous system diseases 7054 3240 9628 PMC5264637__F1 Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom 6395 2717 100 PMC5273810__F4 IFN-gamma signaling pathway 3458 3717 2176 4117 1398 PMC5291092__F8 Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox 213 9817 1728 2729 PMC5293201__F1 Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective 94033 211 9817 1956 PMC5295493__F2 Dietary triglycerides as signaling molecules that influence reward and motivation 7038 255239 4803 PMC5297776__F3 MTOR signaling pathway as a target of molecular therapies 5728 7249 7248 PMC5302168__F8 Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 3717 2885 5922 10253 2475 1848 6194 PMC5308639__F7 Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression 6774 4193 6667 PMC5328851__F2 Schematic diagram demonstrating the mechanism of action of perlecan and endorepellin in angiogenesis and autophagy 7422 5178 2475 PMC5329766__F2 Understanding the intersections between metabolism and cancer biology 5091 2271 2744 1723 PMC5330810__F1 Inference of Cancer Mechanisms through Computational Systems Analysis 353 8833 2766 84890 100 PMC5344425__F1 Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway? 7124 2932 367 2147 1499 PMC5344790__F1 Metabolic interactions with cancer epigenetics 4507 27232 4397 635 10400 4837 PMC5345753__F1 Different molecular mechanisms that can induce time-delay necessary for the generation of oscillations in transcription factor activity 4193 8313 1499 3280 PMC5354077__F8 From big data to diagnosis and prognosis: gene expression signatures in liver hepatocellular carcinoma 355 4118 1610 PMC5354934__F3 Anti-tumor activity of metformin: from metabolic and epigenetic perspectives 3479 5163 2475 PMC5355168__F1 Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma 8651 8821 6774 PMC5356509__F2 Intrinsic and extrinsic apoptotic pathways, the TRADD/NFKB survival pathway, and the growth factor (GF) receptors PI3K/AKT pro-survival signaling axis in CSCs 8772 8717 572 581 331 PMC5358695__F3 Identifying myasthenia gravis (MG) risk genes regulated by drugs and miRNAs in the hsa05200 pathway 6608 367 324 1399 1398 6955 3569 5914 5901 3630 PMC536026__F1 Schematic of the Gp1 mGluR/FMRP pathway 53366 156 157 5728 PMC5362561__F1 Scheme of the metabolic pathway of purines and their relation to hypoxanthine-guanine-phosphoribosyltransferase (HPRT) 158 4860 100 PMC5362762__F5 Exploration of small RNA-seq data for small non-coding RNAs in Human Colorectal Cancer 54115 367 351 5728 PMC5363674__F1 Scheme of the unfolded protein response (UPR) 22926 7494 83939 468 PMC5363986__F1 The Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt 324 3280 8549 PMC5372812__F1 Schematic representation of the general phenylpropanoid pathway leading to major branches of flavonoid biosynthesis and their possible interaction with miRNAs 412 3550 4598 253430 PMC5378054__F1 Transforming growth factor B (TGFB) signaling pathway and its context-dependent regulation 735 57154 23327 PMC5378358__F6 Transcriptome analysis of Corynebacterium glutamicum in the process of recombinant protein expression in bioreactors 5091 1636 11113 4397 4118 PMC5381059__F1 Cancer immunotherapies targeting the PD-1 signaling pathway 324 940 29851 958 PMC5382109__F1 Canonical and non-canonical NFKB pathways 7189 6850 695 8915 5971 5970 5966 974 PMC5382784__F1 Schematic illustration of extracellular oligopeptide metabolism in P 1803 29952 5524 PMC5385290__F2 Folate Nutrition and Blood-Brain Barrier Dysfunction 4548 1719 7298 PMC5385559__F5 Genetic dissection of seed oil and protein content and identification of networks associated with oil content in Brassica napus 5914 9118 7054 PMC5389695__F3 SUMO as a regulator of PCNA ubiquitylation and repair pathway choice 56852 5111 118027463 PMC5390871__F9 Lysophosphatidic acid‐induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1 4018 759 5091 PMC5392402__F1 The workflow of PAIRS 9118 5728 6418 PMC5404780__F2 Mechanism of action of various Hedgehog pathway inhibitors 51311 51284 6608 PMC5409774__F6 Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) 4286 1499 7306 1638 PMC5410396__F2 Promiscuity of PLP enzymes involved in H2S synthesis 875 100188776 847 PMC5412459__F1 Isotopomer formation through carbon distribution of [1,2-13C2]-glucose 7086 8277 11113 4118 5091 PMC5418249__F1 PD-1:PD-L1 mechanisms between T-cells and tumor cells 5728 324 2475 7535 PMC5419340__F2 Diet supplies nicotinamide, nicotinic acid, and nicotinamide riboside as well as the essential amino acid tryptophan 93100 952 10135 4837 PMC5423118__F8 Graphic summary 7083 1635 7084 PMC5427221__F1 Various roles of C3 in complement activation and effector functions 718 1356 174 4179 613 1378 1380 PMC5431132__F2 Endoplasmic reticulum‐associated degradation (ERAD) and unfolded protein responses (UPR) 7494 22926 468 83939 PMC5437397__F7 RNA interference (RNAi) pathway members in malacostracans 27161 26523 4199 51071 29102 PMC5440785__F2 Schematic representation of the contribution of ER stress to the development of atherosclerosis
protein 1 83939 468 7494 PMC5446478__F3 Biochemical and metabolic changes within the tumor 2744 2475 47 PMC5447385__F7 HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease 51808 3146 5879 7099 PMC5450421__F4 Key enzymes in the glycolytic, pentose phosphate, pyruvate, and UDP-N-acetyl-galactosamine pathways are upregulated in the in vivo Giardia foci 5226 2821 4118 PMC5452357__F4 Scheme showed the probably metabolic pathways in patient with PH2 and AGXT2 deficiency 1610 9380 64902 18 5091 PMC5454774__F1 Scar-mediated inhibition and CSPG receptors in the CNS 5728 2475 387 6774 PMC5458139__F5 Mutational Signatures in Breast Cancer: The Problem at the DNA Level 7374 7808 5423 3980 100187761 PMC5460589__F2 The folate biosynthesis pathway and its compartmentalisation in plants (modified from ) 1725 1719 2356 PMC5462018__F5 Conserved ABA signaling pathway in epidermis of H 4602 551 6395 PMC5462749__F8 Working model of Beta-Lap in acute pancreatitis 3146 114548 23411 PMC5465356__F8 ATP-binding cassette transporter A1 regulates phosphoantigen release and VG9VD2 T cell activation by dendritic cells 11119 3652 19 2475 PMC5468232__F11 Estrogen signaling pathway 7018 126669 1610 881 PMC5468443__F1 mTOR Signaling Pathway 3667 5728 5170 7248 PMC5477652__F1 Targeting the cyclin D–cyclin-dependent kinase (CDK)4/6–retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions 2885 126669 1021 1019 2475 6667 PMC5480214__F2 Summary of ergot-alkaloid biosynthetic pathways with emphasis on Clavicipitaceae 8177 100034700 100034703 PMC5482185__F5 Diverse cellular functions of arrestin scaffolds 4193 1499 10763 596 PMC5482974__F4 PACS-2 Akt site and NLS together modulate membrane traffic, TRAIL-induced apoptosis, MAM integrity and the response to DNA damage 1950 6868 472 637 23411 581 PMC5485992__F2 Neuronal defense systems 627 2260 2475 351 3416 57716 7019 2730 1728 PMC5490919__F1 Capsaicinoid biosynthetic pathway 355 1312 1431 PMC5496137__F1 Central metabolic pathways of E 3045 100187828 1636 11113 PMC5501684__F4 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection 3466 367 465 790 920 7054 759 958 978 3565 PMC5501684__F7 Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection 7124 7039 2522 4313 8009 PMC5505220__F3 Modeled mechanism by which FSH via PKA inhibits MKP3/DUSP6 to promote the accumulation of phosphorylated ERK in preantral GCs 1956 2492 2885 1848 PMC5508010__F2 Schematic presentation of the basic catabolic and anabolic processes of a typical heterotrophic prokaryotic cell: glycolytic pathway (GL), pentose-phosphate pathway (PPP) with its oxidative and non-oxidative arms, and tricarboxylic acid cycle (TCA) 6120 7086 11113 1431 4118 4967 PMC5513919__F7 Colorectal cancer metastasis signaling pathway 545 572 1057 PMC5514100__F15 HOXA11-AS co-expressed genes were significantly overrepresented in the non-small cell lung cancer pathway, revealed by KEGG pathway analysis– (http://www.kegg.jp/kegg/kegg1.html) 2272 842 2064 1610 1956 5914 PMC5515628__F1 AD immunopathology and mechanisms of action of targeted therapies 386653 9180 3565 PMC5516115__F1 Speculative model on changes in carbon flux during P limitation in a diatom cell 11113 4118 5091 PMC5516800__F2 Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? 3099 3098 355 PMC5524075__F7 Interleukin (IL)‐13RA1 in myocardial metabolism 4118 324 5091 1431 2271 PMC5527958__F1 RTK activation 3930 3845 5728 673 2475 PMC5533267__F6 Glabridin on the estrogen pathway 619410 2002 6667 3479 5241 PMC5533325__F6 Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) 2056 8027 3458 5292 3569 PMC5555817__F2 Association analysis between chemical activity in the p53RE assay and chemical-induced increased expression of downstream genes in the p53 signaling pathway 472 545 4609 PMC5562273__F2 A simple answer to complex questions: C. elegans as an experimental model for examining the DNA damage response and disease genes 1642 7508 7018 7507 2067 PMC5563070__F6 Cell type-specific metabolism of T 3630 11113 4118 PMC5577134__F3 Biosynthetic gene cluster and proposed biosynthetic pathway of ilamycins 11019 718 729 717 727 PMC5578145__F8 Changes in the photosynthetic electron transfer chain, Calvin cycle, and biosynthesis pathway of sucrose and starch in response to rapid changes in temperature in M 2597 2242 5091 PMC5582926__F9 Schematic description of EET-mediated perturbations in the Wnt1-NOV-PGC-1Alpha-HO-1 pathway in cardiac and adipose tissue of db/db mice 7471 1499 3569 3553 PMC5584049__F6 AC6 and AC6-ΔN signaling 367 6774 100187761 6714 859 PMC5590639__F9 Possible interactions between PVN inflammation and sympathoexcitation in spontaneously hypertensive rats 3480 3553 4615 7099 3146 7852 PMC5593680__F1a Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials 1956 7248 2309 6009 355 2475 47 1977 22937 PMC5593680__F3 Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials 1956 472 7249 6009 355 47 2475 1977 22937 PMC5593685__F1 The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy 3939 3945 7422 PMC5606116__F2 Signaling pathways of IL-2 3718 5163 2475 PMC5607574__F1 Schematic of Hh signal transduction in Drosophila and vertebrates 51684 374654 6608 2717 PMC5610547__F5 Metabolic pathways 572 1431 3240 6611 4507 PMC5618562__F2 Interplay between G-Protein Coupled Receptors (GPCR) signaling regulated by melatonin and GPCR signaling regulating YAP/TAZ 6010 9113 367 6910 1499 PMC5618562__F4 Interplay between melatonin signaling, cell contact-cell polarity complexes, mechanotransduction, and YAP/TAZ 5879 9722 847 387 6910 1499 9113 PMC5623854__F2 Non-apoptotic signaling pathway induced by CD95 1956 6714 841 5335 2475 PMC5635727__F3 In HF, SERCA2a is a vital target regulated by Lut for effective cardiomyocyte contraction and relaxation 5350 7341 4485 PMC5640159__F1 Overview of the role of CtIP in the cellular response to DSB damage 545 472 672 1017 PMC5647276__F2 Daily and annual timing share neurobiological and molecular pathways 7008 3131 2140 PMC5648021__F2 Metabolic Instruction of Immunity 4976 2475 1374 PMC5648141__F1 Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks 8027 5292 2475 PMC5648141__F10 Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks 6262 2475 10379 2670 4170 8027 PMC5649368__F1 Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors 2638 367 6667 PMC5653461__F1 Progesterone Receptors (PR) Mediate STAT Actions: PR and Prolactin Receptor Signaling Crosstalk in Breast Cancer Models 5618 3717 7471 PMC5653694__F1 Circadian rhythms are driven by a vast network of oscillators regulated by multiple interconnected feedback loops that, in turn, synchronize the entire organism 4353 23237 5978 PMC5660707__F5 Scheme of magnesium and calcium transporters and their interaction in the AD brain 54822 140803 351 3553 2475 PMC5661640__F3 Schematic presentation of suggested pathways of PTEN involvement in neuronal survival 5728 572 595 355 2475 PMC5665080__F2 Metabolic reprogramming associated with immune cell activation engages the mevalonate pathway 355 47 2475 22937 PMC5665080__F3 Inflammatory and immune responses to mevalonate pathway dysregulation 3652 4598 3845 3603 PMC5668671__F5 HPVs infect host epithelial cells through TLRs 1956 1950 2475 PMC5669448__F3 Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles 4598 828 4397 PMC5669448__F4 Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles 4397 9051 828 4598 PMC5673281__F3 Bile acids as global regulators of hepatic nutrient metabolism 1956 6714 5163 56848 PMC5677514__F1 Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme 5281 23556 5279 PMC5682390__F1 Metabolic pathways for engineering oleaginous yeasts to produce a variety of different compounds 790 355 8772 4015 84890 PMC5694448__F6 A model of leptospire-induced apoptosis in macrophages through bid-induced release of AIF/ Endog signaling pathway 841 637 2021 PMC5701508__F5 Wnt pathways.Notes: (A) Planar cell polarity (PCP) Wnt pathway in “off” state, with no ligand bound to Fzd receptor leads to Beta-catenin proteasome degradation 6259 6010 324 PMC5701683__F2 Signal transduction in melanoma with regard to the role of the SOX10-MITF pathway 7301 8190 4893 673 2475 595 PMC5705532__F1 Signaling involving TLR2 and TLR4 in strenuous and moderate aerobic exercise 7097 7099 6774 2475 3586 PMC5706558__F7 ERBB signaling pathway analysis 7039 126669 6651 759 PMC5709847__F1 Checkpoint cascade in S 6055 6054 4550 6053 PMC5712298__F1 Immunohaemostasis and infection 4353 7035 7018 PMC5713906__F1 Hh signaling and how pathogens may modify pathway activity 6608 3489 4609 3553 4586 2303 117581 3714 PMC5720788__F1 Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis 1356 355 9118 PMC5721944__F2 Hypothetical schematic connecting basal IP3R mediated Ca2+ release to protein translation, via AMPK and the TOR signalling pathway 7248 7249 90550 PMC5722026__F1 PCP and SHH Signaling pathways 6608 51684 374654 PMC5727250__F1 Simplified overview of mammalian Wnt/B‐catenin and Wnt/PCP pathways 1499 4920 4919 4040 4041 324 5879 6010 2932 51176 4609 PMC5732353__F4 Schematic representation of DAPs associated with theanine (A) and flavonoid (B) biosynthesis 2744 2152 2638 PMC5732752__F9 Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle 2932 891 2597 10818 PMC5734045__F2 Interactions between the Wood-Ljungdahl pathway, the Embden-Meyerhof-Parnas glycolytic pathway, and the mevalonic acid pathway for the synthesis of isoprene 2597 4524 4598 4597 PMC5735818__F1 Schematic overview of the TEK signaling pathway which was built with CellDesigner 4.4 5979 7010 126669 5728 23440 4609 PMC5737637__F2 NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism 10135 65220 23475 130013 203447 93100 PMC5745276__F2a Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway 2713 1499 23043 324 PMC5745449__F1 Modular Schema of the Stress Response Network 2475 5132 4509 5728 3091 PMC5746140__F3 Implication from RAS/RAF/ERK signaling pathway increased activation in epirubicin treated triple negative breast cancer 5447 2475 1431 1636 PMC5749905__F1 mTOR signaling pathway and its upstream elements 4763 5728 2932 6009 7015 PMC5753567__F1 Relation between activated WNT/Beta-catenin pathway and Warburg effect in ASD 324 3939 4040 4041 PMC5761799__F8 Metabolic map of phenolic and glucosinolate metabolism in the primary inflorescence stems of the wild type, ccr1-6, and ccr1-6 ProSNBE:CCR1 lines 65057 1312 790 PMC5766549__F4 Activators and repressors of the regulatory network of genes associated with the bovine milk K-casein content 27445 22937 2160 6769 367 55301 1121 50937 100187761 6476 49 11113 PMC5774705__F3 Hybrid genome assembly and annotation of Paenibacillus pasadenensis strain R16 reveals insights on endophytic life style and antifungal activity 367 4397 201989 2241 473 PMC5790215__F1 Prediction of reaction knockouts to maximize succinate production by Actinobacillus succinogenes 4118 11113 1636 PMC5791865__F1 Impact of MK2- and IKK-dependent phosphorylation on RIPK1 function 8737 841 8772 PMC5799771__F7 CK1Alpha-, 26 S proteasome-dependent turnover of FOXO tumour suppressors in RAS-mutant cancer cells 2475 4303 4899 PMC5806108__F3 Upstream cell signaling pathway of autophagy 5728 7249 6009 2475 7248 PMC5806469__F5 Extended compartmentalized lignin pathway model in B 790 1312 100187761 PMC5806628__F5 Summarization of biological function by a Concept Ontology 4280 7374 7454 5728 PMC5809441__F1 Pleiotropic effects of statins 1401 7018 1071 PMC5812347__F2 Biochemical, Cell Biological, Pathological, and Therapeutic Aspects of Krabbe Disease 2581 3479 7097 PMC5814137__F4 Heterocellular nutrient symbiosis in the tumor microenvironment.Tumor-associated stromal cell populations engage in cooperative metabolic processes with cancer cells in the tumor microenvironment 11113 7008 9242 PMC5817859__F2 Alternative downstream compounds-induced EGFR-TKIs resistance 1958 5728 2475 1956 PMC5817862__F2 TKIs inhibit TKs-mediated signaling pathway 2885 5728 2475 PMC5819365__F1 Fanconi Anemia Signaling and Cancer 472 57697 2191 PMC5819904__F2 Regulation of the Wnt/Beta-catenin signaling pathway 2932 4041 324 595 PMC5822899__F1 The main intracellular pathways and the effects of drugs used in dyslipidemia and obesity in (A) differentiation of preadipocytes into mature adipocytes 4023 7038 335 5140 2638 948 PMC5828008__F6 Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior 4763 5010 9414 2706 PMC5831511__F3 Brain-immune interactions in perinatal hypoxic-ischemic brain injury 4087 7189 3654 3586 PMC5833825__F6 Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescence 6120 3553 7852 PMC5838032__F5 Overview of the metabolism of sugars, amino acids, and related compounds 51083 275 4553 PMC5842404__F4 AMP‐dependent protein kinase (AMPK) signalling pathway 2033 4025 100653365 9118 PMC5845444__F2 13C metabolic flux analysis of E 6866 5805 11113 4118 7086 PMC5853294__F1 Metabolic pathways for TAG biosynthesis in green algae 5091 4099 355 PMC5855670__F2 Death ligand pathway 8772 8717 637 331 PMC5858821__F1 Illustration of self-assembly and accumulation of redox-sensitive PTX-HSV nanoparticles in tumor tissues and their intracellular trafficking pathway 960 140805 4810 PMC5861586__F2 Biological pathways whereby PM2.5 promotes cardiovascular events 23237 7124 7099 6010 6908 PMC5866353__F1 Compiled summary of signaling pathways activated by prostanoid receptor PGE2 receptor 2 (EP2) in osteocytes, neurodegenerative diseases, and colon cancer (see text for details) 6714 3082 1499 1956 PMC5869686__F5 Representation of the TCA cycle and glyoxylate shunt pathway 6389 6390 6392 6391 PMC5871976__F2 Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway adapted from figure 2 of and figure 1 of 5728 6009 7249 7248 PMC5871976__F3 Interrelationship between PIM, AKT and mTOR adapted from figure 2 of 1977 7249 1975 PMC5875170__F2 Regulation of adiposity by mTORC1 6009 64798 64223 8408 PMC5877662__F3 cGMP signaling pathway 594857 2638 5225 PMC5879999__F1 Metabolic interventions suggested by OptForce for increasing production of octanoic acid (C8) in E 51495 11113 4118 8772 PMC5880536__F2 Gut microbiota and IBD: causation or correlation? 196 3553 3603 7124 3458 PMC5889750__F10 The Transcriptional Response of Skin to Fluorescent Light Exposure in Viviparous (Xiphophorus) and Oviparous (Danio, Oryzias) Fishes 716 717 720 PMC5889750__F8 The telomerase signaling pathway is oppositely modulated in platyfish (A) compared to medaka (B) and zebrafish (C) following FL exposure 126669 7015 367 PMC5893408__F1 Sphingosine-1-phosphate receptors and innate immunity 1901 9294 1903 8698 53637 6010 5728 PMC5896264__F1 Central C metabolic network of Brucella (adapted from ) 7086 6120 1896 2597 11113 4118 PMC5898978__F1 Prostaglandin E2 as a Regulator of Immunity to Pathogens 4049 5226 4050 PMC5899973__F4 Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis 8213 6714 4609 2353 3458 3553 PMC5903986__F1 Astrocyte glycogen and lactate: new insights into learning and memory mechanisms 627 5662 6714 2475 PMC5908807__F1 Hippo signaling and YAP phosphorylation and translocation 4134 9113 26524 PMC5908849__F5 Metabolic and regulatory network of G 2444 7086 6120 27040 65057 7054 PMC5911514__F2 Primary Cilia as a Signaling Platform for Control of Energy Metabolism 324 6608 1499 51684 PMC5912903__F1 PRPP riboswitches and their regulatory network 2638 25801 55075 5814 5813 PMC5915462__F1 Pathways of deoxyribonucleotide metabolism in mammalian cells 1723 158 8833 3630 PMC5915505__F2 HIF degradation pathway in normoxia and its stabilisation in hypoxia and pseudohypoxia 2271 7428 81888 PMC5916231__F1 Heme synthesis pathway 210 3145 9049 7390 1371 5498 2235 PMC5920436__F1 BCR pathway activation 613 973 4067 695 6850 2475 PMC5928575__F5 PGE2 mediates early implantation 1956 6387 7852 PMC5930279__F1 Effects of choline in lipid metabolism pathway 355 5091 10400 PMC5931255__F2 Hedgehog signaling pathway inhibitors 6469 6608 51684 PMC5938061__F7 Gastrin-CCKBR–GA12/13–RhoA–ROCK signaling in pancreatic cancer 887 759 355 PMC5938095__F8 TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus 627 761 5091 PMC5938286__F3 Illustration of JAK/STAT signaling pathway 6714 2475 4609 596 PMC5940273__F3 Repressing the repressor: Ezh2 mediates macrophage activation 9021 4615 7189 PMC5942524__F3 Hereditary Disorder, Organismal Injury and Abnormalities, Respiratory Disease Ingenuity Pathway Analysis (IPA) Network 1401 3586 3552 PMC5948768__F12 ATP6AP2-induced neural differentiation 10159 51083 2670 PMC5949363__F7 Interaction between T follicular helper (Tfh) and B cells initiating synergetic effect of IL-21/IL-21R and CD40 ligand (CD40L)/CD40 to promote plasma cell differentiation and antibody production in EAE 29851 958 613 6850 759 5091 4340 PMC5953777__F3 Cancer-relevant signaling pathways 1356 3550 572 637 581 780904 790 6093 PMC5955724__F1 Working model for Eph receptor function in tumor promotion and tumor suppression 2064 1956 387 PMC5958082__F2 ADT DEGs enriched in integrin signaling pathway-associated transcripts 7414 7791 153642 2580 100187761 PMC5966718__F2 Detoxification of ammonia in the urea cycle and production of ornithine 435 5009 4942 PMC5971020__F1 RIG-I-like receptor signaling pathway 1540 10010 8772 7124 53918 6955 8717 3558 51071 22808 PMC5972548__F2 Wnt signaling pathways 1499 4920 6259 6010 PMC5975105__F1 Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins 335 19 9619 3949 4864 10577 22937 3156 114880 114883 PMC5975367__F3 Targeting Autophagy in Cancer 1950 1956 4193 5728 472 6774 2475 3725 PMC5977747__F2 Possible scenarios for PanDrugs therapeutic candidates 3082 1950 1956 2475 PMC5979464__F4 Canonical B2-adrenergic receptor (B2-AR) signaling response, the anti-inflammatory cytokine profile mediated by protein kinase A (PKA), and the major anti-inflammatory cellular mediators of the resulting anti-inflammatory immune response 367 2869 2870 6011 156 PMC5982750__F3 SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand 7515 2950 2067 PMC5986049__F1 Control of erythropoietin (EPO) synthesis by the oxygen sensing pathway 7428 2056 405 PMC5986633__F7 Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death 587 28999 6009 7249 2475 PMC5993186__F1 Coproheme decarboxylases - Phylogenetic prediction versus biochemical experiments 3145 7390 7389 PMC5997273__F1 Road to Crohn’s disease 4615 83939 55054 PMC6001073__F5 The gene or protein expression of GLUT1, HK1, PGM1, UGP2, GALT, GALE, SLC35A2, LALBA, and B4GALT1 on the lactose synthesis pathway throughout lactation 3906 7360 2582 2592 51083 7355 2683 PMC6002666__F4 Predicted models for central metabolisms of A 275 4975 7263 875 PMC6005741__F1 The force is strong with this one: Metabolism (over)powers stem cell fate 2475 1956 324 1499 47 5212 PMC6006503__F1 Role and molecular pathway of IL-32 in cancer 331 1499 9235 6774 3553 PMC6008220__F3 Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes 1431 3458 7054 PMC6014315__F1 Impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment 5728 7249 7248 8821 PMC6020056__F1 Complement cascades 717 718 727 PMC6022935__F1 Streptomyces lividans major secretory route (Sec pathway) 5654 27429 6957 PMC6023588__F3 Schematic of glycolysis and ancillary glucose metabolism pathways 3098 5315 5091 355 PMC6023588__F4 Metabolic mechanisms of exercise-induced cardiac growth 1051 163732 2475 PMC6027909__F1 Primary mechanisms by which AIBP protects against macrophage inflammatory response 19 6774 4615 3553 PMC6028121__F4 Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment 324 5159 1499 998 PMC6028781__F4 Central carbon and nitrogen metabolism of Arabidopsis thaliana active in most growth stages and conditions simulated 2695 4118 11113 1356 PMC6030854__F1 The effects of the Insulin-like Growth Factor 1 (IGF-1) on muscle growth and homeostasis 3479 3480 64798 PMC6033520__F1 Hedgehog pathway in nonalcoholic fatty liver disease 5091 6608 3562 PMC6040236__F7 Schematic for alternative complement pathway activity in fHm/m/fP−/− mice 2271 727 718 5617 6120 PMC6049856__F1 CAD/POLD2 gene expression is associated with poor overall survival and chemoresistance in bladder urothelial carcinoma 6418 790 1723 7372 PMC6051722__F4 Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides and Incident Cardiovascular Disease 7038 3949 4023 1071 PMC6052717__F2 Signalling pathways involved in ccRCC 3569 6608 6774 PMC6061156__F1 Ag processing and presentation pathways followed by CPP-Ag in dendritic cells 340451 920 941 PMC6070887__F2 Metabolic rewiring following T cell activation 355 2475 50943 3586 3458 3569 PMC6071257__F1 Epstein–Barr virus (EBV) oncoproteins affecting p53 signaling pathways 7874 4193 51147 PMC6071399__F3 Analyzing Toll-like receptor signaling pathway by QIAGEN, KEGG and wikipathway websites and drawing pathway by Pathvisio software 100187761 6955 100379198 3630 26136 8726 PMC6072898__F3 Mechanistic aspects of the antioxidant and anti-inflammatory action of berberine 23411 6010 7351 PMC6073271__F1 Simplified diagram of the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway for phytohormone abscisic acid (ABA) biosynthesis with components occurring in the Chloroplast and Cytosol 718 727 3652 PMC6073766__F1 Major downstream signaling pathway of mTORC1 and mTORC2 64798 8408 7942 10797 PMC6073924__F5 Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges 3082 2353 8195 PMC6083487__F4 Cyclins and cell cycle regulation is the top pathway downregulated by citalopram treatment 545 5805 4661 PMC6090502__F9 Model for NG2 ICD-mediated intracellular signaling in OPCs 2475 29904 1975 1938 5091 367 PMC6099543__F7 Proposed biosynthetic pathway for nine ginsenosides 5925 369 2147 PMC6100584__F1 Mechanism of Hedgehog pathway activation 6608 5727 6469 2932 51684 4609 PMC6101676__F1 Mevalonate-isoprenoid-cholesterol pathway and pharmacological agents that inhibit the synthesis of key intermediates 3156 727 3652 6010 PMC6102368__F3 Crosstalk between Notch and tumor necrosis factor A (TNFA) in the tumor environment 8650 3170 3280 3553 4342 PMC6102695__F7 Kyoto Encyclopedia of Genes and Genomes pathway map illustrating ‘hsa05200: Pathways in cancer’, as identified by pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery 470 3034 8564 572 PMC6116371__F3 CircRNA and cancer-associated signaling pathways 1956 9869 6774 PMC6119869__F4 Mechanisms of resistance to SMO inhibitors 6608 5727 51684 2735 PMC6121658__F1 MDSCs expansion is regulated by several factors in vivo microenvironment 90865 6761 196 2475 6774 PMC6122031__F9 Putative regulatory mechanisms of the FNM process 108348016 4602 324 PMC6125400__F4 Simplified KEGG pathway “Proteoglycans in Cancer” with H3K4me3 and H3K27me3 enriched genes 23365 387 79923 5566 5596 60 4609 5328 5329 4134 PMC6129971__F1 Pathways of one-carbon metabolism 4524 4397 5212 PMC6131422__F1 Substrates involved in caffeine biosynthesis pathways and its other related pathways catalysed by enzymes that were encoded by genes carrying the TAVs identified from this study 7054 100187761 7808 2695 PMC6135464__F5 Pathway visualisation 26136 8139 100187761 6476 PMC6142822__F3 Gut-brain communicates with the brain mainly via three pathways of the microbiota–gut–brain axis 627 7039 3603 PMC6148080__F19 SST5signaling leading to inhibition of hormone secretion and proliferation 6750 51083 2475 2638 759 3717 PMC6149884__F1 VAV1 signaling in lymphocytes 1911 6010 7409 4851 PMC6153639__F1 Folate structure and metabolic pathway 4693 2356 1719 1725 PMC6158478__F2 Biochemical pathways of lysophosphatidic acid synthesis and degradation 4018 9170 4099 5338 PMC6170333__F1 The synthetic pathway for development of the hyperbranched polymer based theranostic nanomedicine incorporating either A8 (HBP/A8/DOX) or A13 (HBP/A13/DOX) 91653 100187761 26959 PMC6172959__F7 Poxviruses evade cytosolic sensing through disruption of an mTORC1-mTORC2 regulatory circuit 115004 253260 3661 29110 PMC6175696__F5 CA biosynthetic pathway starting from C3 and C5 precursors 727 718 5053 790 PMC6190667__F8 Carbon contribution of medium ingredients to riboflavin based on combined parallel 13C-labeled tracer studies using [13C2] glycine, [13C] formate, [13C5] glutamate, and [U13C] yeast extract 2695 4118 2191 PMC6194161__F1 TLR and CLR interactions with helminth-derived products 325 4615 7099 6850 114548 7098 PMC6206292__F3 Diagram of carbohydrate metabolism pathways with their related DEGs (differentially expressed genes) and DAMs 4489 4284 2821 6476 1431 4397 PMC6206292__F5 Brief diagram of amino acid metabolism pathways with related DEGs and DAMs 125061 15 635 438 PMC6207917__F6 Mechanism of DQP on cardiac lipid and glucose metabolism 1374 33 2932 6342 PMC6212468__F2 Integrin linked kinase (ILK) signaling 5728 759 6010 1832 5073 4613 PMC6212468__F3 Rho GTPase family signaling 6010 7454 5251 5891 85451 759 PMC6214770__F7 Proposed signaling model of crosstalk between NIS and PTEN signaling pathway 5728 2475 387 PMC6221181__F1 Glucocorticoids regulate NK cells and ILC1s functions upon MCMV infection 3458 114822 1831 PMC6222618__F1 Post-squalene cholesterol biosynthetic pathway 1718 10682 6309 PMC6224293__F1 Pathways involved in the synthesis of the main glycerolipids present in Arabidopsis mitochondrial membranes 907 5662 5091 283871 PMC6230871__F3 Genes altered in NHE1 transgenic hearts were enriched in KEGG hypertrophic cardiomyopathy (HCM) pathway 6444 6442 6443 6445 1756 4633 7124 4634 4624 PMC6235774__F1 Signaling reactions induced by thrombopoietin 7066 4352 8660 5581 2017 1398 5566 673 3265 3845 7006 100124696 2475 5580 100187761 759 2548 5447 PMC6237576__F3 Contributions of PCAF‐induced acetylation to the development of liver injury and mediators of inflammation 23411 1869 7071 50943 324 PMC6255977__F1 Transcriptome response of Salvia miltiorrhiza to overexpression of AtPAP1 1431 1312 790 729230 PMC6258353__F3 Proposed biosynthetic pathway for TNL A (1) supported by the isolation of congeners or shunt metabolites 4–11, as indicated by the dashed arrows 3652 79931 79155 10318 PMC6263005__F1 Neuroprotective modulation of the unfolded protein response in Marinesco-Sjögren syndrome: PERK signaling inhibition and beyond 22926 7494 83939 468 PMC6263343__F3 Heme biosynthesis 210 2235 7389 130749 PMC6275466__F2 NOTCH signaling pathway 8650 5045 1024 PMC6278507__F6 Molecules associated with ‘focal adhesion’ pathway 387 3611 5728 3725 126669 2885 PMC6280921__F1 Cross-talk among different signaling pathways involved in MDSCs expansion, activation and function 574452 4615 5728 920 PMC6290135__F1 Polyamine biosynthetic pathway in single-celled parasitic eukaryotes 1984 7038 1356 83475 1611 100187761 2937 PMC6291243__F2 Biosynthesis of the ADR-GlyU disaccharide core 17a 643414 643418 340654 PMC6293973__F1 The Receptor for Advanced Glycation Endproducts (RAGE) and Mediation of Inflammatory Neurodegeneration 3146 4397 1729 PMC6299239__F2 Tankyrase-mediated Wnt/Beta-catenin signalling 324 81847 1499 PMC6304875__F1 General overview of the autophagic pathway and its regulators 23192 8408 9706 2475 PMC6306679__F4 Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy 23530 952 349565 23057 10135 PMC6306858__F1 Primer of the inflammatory cascade 4615 3550 7054 3603 355 3553 PMC6314025__F3 Model unifying proteostasis in ER and cytoplasm of Plasmodium falciparum in mechanisms of artemisinin resistance 1998 83939 5266 PMC6316632__F1 Simple central carbon network of the Xanthomonas oryzae pv. oryzae BXO43 strain 6866 11113 4118 PMC6319725__F8 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells 7290 8817 7097 100 23387 6667 10135 847 8772 10514 PMC6319725__F9 Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells 8772 4086 10135 847 100188835 PMC6321258__F1 Interaction between metabolism and histone acetylation and DNA/histone methylation 5132 47 55902 PMC6322862__F1 Schematic diagram of a simplified model for glucose-mediated mitochondrial transport regulation 2548 8473 10724 4149 PMC6324838__F1 Overview schematic of the proposed relationship of inhalant organic dust exposures induction of bone loss 7099 7097 4615 2919 64127 PMC6330548__F2 The proposed genetic interactive network among genetic factors in lignin biosynthesis pathway, which exemplified by S‐lignin biosynthesis 1312 790 5901 PMC6332464__F2 Schematic representation of glycolysis, the pentose phosphate pathway (PPP), glutaminolysis and lipid synthesis and their inhibition by polyphenols in breast cancer cells 2147 26227 3939 PMC6335096__F4 Peroxisome biogenesis 439 5190 5189 5824 5830 5191 PMC6340093__F1 Interacting enzyme in the monolignol biosynthetic pathway 6101 1312 65057 790 5879 PMC6341806__F2 Summarized molecular pathway of BDNF/TrkB's oncogenic role 627 1956 6774 PMC6343537__F2 Putative pathway for antagonistic Rab35/Arf6 regulation in presynaptic terminals 5872 23527 57465 PMC6346072__F1 Metabolism of sulfur amino acids and H2S synthesis 27232 875 4357 79587 PMC6348814__F2 ALDH1A1 regulation, potential retinoid signaling pathways, and functional effects of ALDH in CSCs 216 4089 22933 1499 4087 4088 54567 PMC6350546__F2 Targets and the simplified downstream effects of their autoantibodies encountered during dermatomyositis 57506 6651 4553 PMC6351787__F5 Hexosamine pathway 729 727 717 8473 10724 PMC6356367__F3 Upstream factors of the TOR pathway 1950 1956 6009 PMC6362574__F1 Metabolic engineering strategies for enhancing citric acid production 316 2717 11113 4118 PMC6365454__F2 Chronic hyperglycemia impairs neuron function 627 718 7442 PMC6379961__F1 Overview of PI3K/AKT/mTOR signaling pathway 5728 5163 2475 PMC6385748__F7 Graphical representation demonstrating the role of PDK4 in obesity-induced MAM formation and skeletal muscle IR 2308 5166 7416 3667 PMC6387699__F1 Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications 4846 2638 80312 PMC6390811__F1 GPCR/Beta-arr-dependent signal pathways controlling cell survival, cytoskeleton remodeling, and gene expression, leading to enhanced cell growth, invasion and metastasis 6714 1499 5900 29127 3611 387 2475 5898 389 6925 PMC6394863__F6 Fluid forces shape the embryonic heart: insights from zebrafish 59341 57493 83605 3084 3796 7484 2064 25937 PMC6395653__F3 The metabolic network 5064 4118 11113 PMC6398521__F4 Effect of 1,25(OH)2D3 and AB on the key reactions involved in the sphingolipid metabolic pathway 10715 253782 91012 204219 29956 79603 64781 2638 PMC6400107__F5a Laser Microdissection-Based Tissue-Specific Transcriptome Analysis Reveals a Novel Regulatory Network of Genes Involved in Heat-Induced Grain Chalk in Rice Endosperm 2077 4602 9242 4117 PMC6409748__F2 TLR-7/-8 signaling in dendritic cells 51284 3654 7189 3665 7187 4615 PMC6412627__F3 Regulation of the expression and cleavage of sterol regulatory element-binding protein-1c (SREBP-1c) and the transcriptional activation of the acyl-CoA:glycerol-sn-3-phosphate acyltransferase1 (GPAT1) gene 3667 22937 51141 PMC6413682__F8 Negative regulation between FoxO3a and EPS8 in EGF/PI3K/Akt pathway 1956 2475 2059 6774 PMC6414239__F1 Metabolic perturbations in classic galactosemia beyond the Leloir pathway: insights from an untargeted metabolomic study 2592 101448070 2582 PMC6421779__F1 Canonical pathway for miRNA biogenesis 29102 54487 5901 9924 255967 PMC6424911__F4 Changes in transcripts related to phenylpropanoid metabolism in response to aphid feeding in susceptible plants 790 1312 5805 PMC6425641__F1 Schematic presentation of strategy for SLA-PEB biosynthesis in E 8205 7909 6503 2010 PMC6425986__F4 Proteomic Analysis of the Human Anterior Pituitary Gland 405 6476 56914 PMC6429987__F1 Brief summary of reciprocal regulation between AMPK and mTOR pathways 7249 7248 6009 2475 PMC6435963__F1 Complement activation cascades and functions 5648 10747 720 718 PMC6436826__F1 Molecular Mechanisms of Regulation of Sphingosine Kinase 1 1674 64781 4026 PMC6441080__F7 The regulation of CP biosynthesis and the attachment to PG in S 1356 822 1363 PMC6446704__F2 Regulation of FABP4/aP2 secretion from adipocytes 2167 7038 7959 4099 PMC6446709__F1 Pathways for glycerolipid synthesis 4018 5091 4099 PMC6449901__F4 Summary of genes involved in the glycolate production pathway 1611 11113 4118 PMC6459169__F4 Transcriptional coverage of penguin transcripts on the vertebrate Janus kinase/signal transducers and activators of transcription (JAK-STAT) (#04630) (A) and vertebrate Toll-like receptor (TLR) signaling pathway (#04620) (B) 7975 929 27040 8544 PMC6459935__F1 Bioinformatics analysis of direct ERRA target genes in mouse liver 6256 5465 100187761 5066 PMC64750__F4 Metabolic pathways related to cell-wall formation 100188863 1312 790 PMC6477581__F1 microRNA-Mediated Tumor–Microbiota Metabolic Interactions in Colorectal Cancer 2475 3939 2194 PMC6478549__F1 An overview of major metabolic pathways in resting and activated fibroblasts 2539 5209 2147 26227 29968 5723 9049 2744 PMC6478758__F3 Pervasive regulation of TLR signaling pathway by miR-146a/b family and miR-125a~99b~let-7e cluster 7099 4615 6774 7189 3654 7124 6348 PMC6486704__F2 Chemoautotroph Ca 4841 4693 7263 2799 PMC6492940__F4 Essential metabolites 2936 57716 3925 443 PMC6494966__F1 Schematic depiction of processes and pathways involved in iron homeostasis and regulation in the brain 351 3949 26234 PMC6496019__F7 Schematic diagram proposed by the present research 22926 7494 83939 468 PMC6499807__F9 Mechanistic scheme of lncRNA lnc-TALC in GBM 6774 2309 4255 PMC6504851__F2 Diagram showing differentially expressed genes in BXW-resistant and BXW-susceptible genotypes of banana after inoculation with Xanthomonas campestris pv 2077 4602 5728 9242 2241 PMC6514310__F1 mTORC1 and mTORC2 64798 64223 2475 253260 PMC6518034__F2 Schematic drawing of the details of the signaling pathways of five major cardiomyopathies 5728 324 355 572 581 PMC6520855__F2 Targeting the Hedgehog pathway 374654 6608 9149 23476 PMC6522716__F5 Differential expression and bioinformatics analysis of circRNA in osteosarcoma 5728 5266 3652 PMC6523340__F4 Simplified biosynthetic pathway of lignin and flavonols 1312 790 65057 PMC6523474__F2 Acute phase response (APR) is central to the FL induced response in skin, brain, and liver of all three model organisms 54210 4282 79923 3146 2322 3611 5447 51295 2475 4803 1270 940 7852 5008 7006 100124696 7276 183 57817 3240 PMC6528196__F3 Predicted metabolic pathway of lignocellulose-derived inhibitors 5891 8081 1690 PMC6534162__F2 Stimulating Cardiogenesis as a Treatment for Heart Failure 3084 890 983 693175 PMC6537480__F2 Signaling pathway mediating cardiovascular protection of OT 9927 4342 790 PMC6539103__F2 Potential roles of aberrant activations of MAPK and PI3K signaling pathways in pathogenesis of PWS/SWS 5921 2695 6714 2776 5728 2475 PMC6540047__F4 BRO modulation of RV-induced NFkB target gene expression 10135 7097 4792 8837 1616 22797 64332 PMC6546329__F3 Intestinal luminal putrescine is produced by collective biosynthetic pathways of the commensal microbiome 435 5009 549 PMC6550017__F1 HH signaling 6608 51684 2121 2735 PMC6551999__F1 A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? 875 1610 847 PMC6562018__F2 Reduction in AAs (EAAs, BCAAs, and Met) induces uncharged tRNA and activates GCN2, eIF2A and ATF4/5, resulting in increased FGF21 production 3479 27232 468 PMC6562601__F1 De novo pyrimidine and purine synthesis pathways 5471 2618 5198 790 10606 158 471 1723 8833 7372 PMC6566596__F4 Cross-talks between tumor and immune cells determining chemo-immune-resistance 283871 920 7018 PMC6566956__F2a Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells 22926 1998 83939 468 PMC6567815__F2 Synthesis and function of NAD+ in the cytoplasm and nucleus 23475 55191 10135 PMC6570498__F1 Endogenous H2S production, metabolism during methionine cycle 4397 875 847 PMC6574129__F5 Aurora kinase plus BTK blockade inhibits the chronic active BCR pathway and induces apoptosis in DH/DE-DLBCL 2597 6850 5336 PMC6575164__F3 Possible mechanisms of action of targeted polyIC 57506 7098 83939 7187 3661 29110 PMC6589336__F2 Synthetic Biology Tools for Programming Cell and Tissue 80312 100188857 100271694 7808 930 PMC6589502__F2 Generalized Lymphatic Anomaly and Gorham–Stout Disease: Overview and Recent Insights 1948 7424 2050 5290 2717 2475 5266 PMC6595688__F1 PKM2: Junction of Metabolic Networks and Signal Cascades 2147 11113 4118 367 7054 PMC6597757__F2 Illustration depicting primary signalling mechanisms of different neuronal and astrocytic proteins encoded by genes implicated in ID/ASDs 4204 85358 2475 PMC6598098__F6 Putative C4pathway in Alloteropsis semialata 5183 4118 5091 PMC6598629__F1 The supraspinal locomotor network 5091 7054 2821 PMC6610485__F2 Mechanisms by which bacteria influence cancer development and progression 6774 1499 201633 PMC6616371__F4 Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing 2885 5894 2002 PMC6616624__F5 Main energy metabolism and carbon/nitrogen fluxes in heterocysts 2539 5183 1431 11113 4118 PMC6619735__F9 Proposed model illustrating the mechanism of arctigenin-mediated AB production inhibition and AB clearance promotion 351 23621 83939 2475 8408 PMC6621164__F9 Model of the function of CTTNBP2 at dendritic spines 5879 6714 83992 PMC6639181__F9 Summary scheme represents the possible pathways of drug sensitive and drug resistance to cordycepin in MA‐10 mouse Leydig tumor cells 22926 2475 83939 7494 468 1019 467 PMC6645632__F5 The hexosamine biosynthetic pathway (HBP) in the heart 8473 10724 2821 PMC6650384__F2 Changes in placental signaling in IUGR 3479 3480 83939 PMC6657305__F1 Cellular Compartmentation and the Redox/Nonredox Functions of NAD+ 8564 4860 23498 10135 PMC6667742__F7 A model demonstrating the multiple platelet activation pathways inhibited by the methylated metabolites of quercetin 5336 6850 27040 PMC6668540__F2 TLR signaling pathways 51135 7189 23118 3665 3661 3603 PMC6668592__F2a GC/MS and LC/MS-based Tissue Metabolomic Analysis Detected Increased Levels of Antioxidant Metabolites in Colorectal Cancer 7086 6888 875 23475 PMC6676383__F5 Metabolic pathway map showing fold changes of leaf metabolite concentrations of Plantago lanceolata subjected to different precipitation and temperature treatments 11113 4118 847 PMC6678366__F4 Molecular mechanism of soft-jet plasma-induced cancer cell apoptosis via the mitochondrial intrinsic pathway and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activation 847 581 3014 PMC6678716__F2 CSCs-activated signaling pathways: Schematic representation of the signaling pathway responsible for induction and maintenance of CSC state 6608 7046 4041 3717 4040 4485 9113 6774 26524 324 51684 1499 3569 PMC6685392__F4 Multi-loop model of AD: an integrated perspective on the Wnt/GSK3B, Alpha-synuclein, and type 3 diabetes hypotheses 2932 22943 3416 PMC6696068__F1 Canonical Wnt/Beta-catenin signaling pathway 324 8658 2932 607 332 595 PMC6704133__F6 Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma 1956 3688 6714 3689 6010 PMC6704427__F1 Genetic abnormalities in HNSCC contribute to poor tumor immunogenicity 6657 5290 2475 PMC6708273__F6 Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic Beta-Cells to Type 2 Diabetes 5163 2885 2475 5080 389692 4609 PMC6710771__F1 Ang/Tie2 signalling in the diabetic eye, including crosstalk with the VEGF pathway 6120 6714 596 581 1499 2932 PMC6712508__F6 The proposed mechanism of TN-C release following RV infection of bronchial epithelial cells 3949 3383 51284 7098 PMC6713153__F2 Signalling pathway induced by ManLAM 7096 7097 4615 PMC6714079__F4 Central carbon metabolism of T 2821 5226 4118 11113 PMC6714168__F2 The role and proposed mechanism of Wnt5a in psoriatic arthritis 7474 4920 6010 PMC6715949__F1 Mucosal innate immune responses to STIs in the female genital tract that could potentiate HIV transmission risk 7097 4615 3661 3665 3553 PMC6722098__F1 DEGs’ products protein-protein interaction network for each mineral 5550 1311 6651 2515 79135 10631 54205 6924 1462 PMC6722688__F1 A simplified diagram of the metabolic fate of maternal dietary choline and its delivery to the developing fetus 10400 8504 5091 PMC6724557__F1 TNFR2 can modulate TNFR1 signaling 8717 8772 7186 PMC6726749__F10 Based on our findings, there are several crucial paths, including PI3/AKT/mTOR as well as HIF-1A activation (in hypoxia) and inhibition (in normoxia) 5266 5728 2475 64344 80705 PMC6745797__F1 Major hallmark of immunosuppression in the TME through diverse pathways in EGFR-mutant NSCLC 50943 2932 374 1956 6347 PMC6746687__F3 Schematic diagram of EB virus involved in the G1/S transition 472 1820 1021 1019 5111 PMC6747043__F3 Endoplasmic reticulum (ER) stress-mediated inflammation 22926 7186 7494 83939 468 PMC6747339__F1 Schematic representation of ERK1,2 signalling regulation of channels and transporters along the nephron 1638 5741 5894 PMC6752947__F6 Tbx1-Isl1-Met genetic pathway regulates only a subset of CPM-derived muscles 1368 4397 5091 6899 3670 3082 4617 5081 4656 PMC6765251__F6 Putative metabolic map of a bacterium within the miscellaneous Bacteroidales metagenome reconstructed from the metagenomic data 275 4118 51228 PMC6770402__F5 Apoptosis pathways (hsa04210) and targets of cordycepin 1616 23033 686 7054 PMC6770591__F7 Scheme of the de novo synthesis pathway of glutathione 875 1491 2937 PMC6773405__F4 Focal adhesion pathway with enriched genes DOCK1, FLNB, FLT1, FYN, IGF1R, PPP1R12A 175 7408 2316 5649 7414 1101 5728 100187761 PMC6774422__F2 LRRK2 substrates involved in vesicle trafficking and synaptic transmission 10890 201475 11021 8934 53917 100170220 22931 4905 339122 PMC6779911__F6 Configuration of organellar GS-GOGAT cycles and split-organelle arginine biosynthesis 58510 1356 55750 11113 435 PMC6782151__F11 Mechanism of microglial activation by fibrillarBA and PrP peptides responsible for neurotoxicity 4067 6850 2885 PMC6784888__F4 Leveraging single-cell genomics to expand the fungal tree of life 100187761 1356 5091 PMC6789489__F1 Action of methylxanthine (MTXs) in glioblastoma (GBM) 2475 3066 2670 PMC6789908__F1 Rationale and workflow of CRISPR-BEST 2638 5673 5066 339855 PMC6791698__F1 Metabolic pathways concerning dTTP biosynthesis 4693 2731 1719 PMC6799833__F7 Potential mechanisms of fluoxetine in the remission of AD 627 351 4204 25942 3065 PMC6811524__F6 Canonical and non-canonical Wnt signaling manipulation by pathogens occupying an extracellular niche 324 2934 1499 4781 PMC6814074__F2 Non-genomic mechanisms of thyroid hormones action in the brain 7054 5594 2475 6774 PMC6815035__F7 MicroRNAs and their regulatory networks in Chinese Gushi chicken abdominal adipose tissue during postnatal late development 5155 85366 5156 PMC6820234__F1 Heme biosynthetic pathway and experimental porphyria models 3145 7390 2235 10058 5498 1371 7389 9429 9049 1499 1644 4353 PMC6823181__F1 GPER signaling pathways in cancer cells 1956 6010 581 2353 PMC6823874__F1 Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response 5426 11201 5447 PMC6824679__F2 Synthesis of phosphatidylinositol and acyl chain remodelling 4018 132001 283871 5091 7038 79143 PMC6826160__F5 ROS‐dependent priming and activation of the intrinsic cell death pathway 842 7417 4976 PMC6830055__F1 Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance 157739 8473 23411 PMC6851023__F2 Pathways leading to IDO enzyme production and regulation 196 7124 9021 PMC6858495__F3 pRB/E2F pathway dysregulation leading to unrestricted CASP3 gene transcription 1019 1021 836 PMC6861747__F17 Antidepressant-like effects and mechanisms of GXDSF via mediation of the CaMKII-CREB-BDNF signalling pathway in chronic unpredictable mild stress (CUMS)-induced depressive rats 627 7263 10468 4803 PMC6862548__F2 Estrogen biogenesis, and its metabolism 6714 6667 2002 2321 PMC6863373__F2 Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies 468 9759 1647 54498 PMC6871180__F3 Molecular mechanisms of arrhythmogenic cardiomyopathy 2932 4771 4485 9113 26524 PMC6873406__F9 Non small cell lung cancer KEGG pathway 2272 572 842 1956 2064 581 51426 3718 11186 1610 PMC6874456__F8 Schematic model of how TG NPs ameliorate CKD progression 594857 7038 22926 PMC6878604__F1 FGFR pathway.FGFRs dimerize upon ligand building and trigger a downstream cascade of signaling pathways 10818 2885 53834 PMC6880621__F2 NLRC5’s role in renal diseases 84166 3099 7045 PMC6882011__F4 Pathway display visualisation of significant changes in primary/intermediary metabolite abundances observed between COL2246 and ECU72 during the infestation cycle 3652 3416 85451 PMC6892507__F5 Gene expression is associated with virulence in murine macrophages infected with Leptospira spp 6955 2021 472 PMC6893313__F8 Representative model of the MMP-2 and MMP-9 secretion induced by leptin in a cultured model for breast cancer 6714 6774 3717 PMC6894473__F2 Schematic view of the TLR4 signaling pathways between MSCs and HCC cells in inflammation microenvironment 9242 7099 4615 7189 114609 3929 PMC6895604__F2 Targeting senescent cells in translational medicine 759 5728 472 7808 545 3930 572 2475 581 3516 4703 PMC6901966__F10 Protective effects of farrerol on CDDP-induced AKI and the underlying mechanism 50507 9817 581 114548 PMC6920770__F4 Angiogenesis activation through reactive oxygen species (ROS) via hypoxia dependent and hypoxia independent pathways 5879 5728 2475 4313 4318 PMC6921025__F1 Overview of PI3K-AKT signaling pathway 157313 1399 5728 2475 253260 PMC6923668__F1 Mechanism of mutant CALR-induced MPN and approaches for therapeutic targeting 811 4352 3717 324 PMC6929077__F1 Nicotinamide (NAM) and Nicotinamide Adenine Dinucleotide (NAD+) metabolism 203447 10135 93100 65220 23475 4837 PMC6930621__F10 Hepatic metabolic pathways of Met 4397 5212 4524 875 PMC6933909__F8 Schematic representation of the working model 5728 4853 2475 2034 79733 PMC6934488__F6 Metabolic network diagram between phenylpropanoid biosynthesis pathway, pentose phosphate pathway and proline metabolic pathway 790 5625 1312 PMC6941427__F9 The regulatory network of key long non-coding RNAs (lncRNAs), genes, and metabolites involved in flavonoid metabolic pathway, terpenoid metabolic pathway, and jasmonic acid/methyl jasmonate (JA/MeJA) biosynthesis and signal transduction pathway 4015 790 4598 2641 PMC6945844__F3 High Flux Through the Oxidative Pentose Phosphate Pathway Lowers Efficiency in Developing Camelina Seeds 3240 11113 4118 PMC6945997__F3 Recognition of Candida species is mediated by Toll-like receptors (TLRs), C-type lectin receptors (CLRs) and nucleotide-binding oligomerization domain (NOD) receptors 64127 114548 64170 5894 8915 10892 7054 3553 PMC6951458__F1 Mnk 1/2 signaling 1977 3178 10253 PMC6952935__F1 Schematic representation of the metastatic cascade 7422 4397 57124 PMC6952948__F5 The role of mTOR in glutamine metabolism and hexosamine biosynthesis 4609 2744 6675 PMC6959606__F4 Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector 5183 8566 3423 3033 PMC6963649__F2 Simplified schematic diagram showing synergistic and antagonistic interactions between the ABA signaling pathway and other hormonal signaling pathways during abiotic and biotic stress 2077 4609 4602 PMC6966089__F2 Methanol condensation cycle (MCC) for assimilation of methanol into higher alcohol with maximal carbon conservation 6120 7086 4163 PMC6977016__F3 Role and mechanisms of frequently-studied traditional herbs in treating NAFLD 8087 114548 4615 23411 22926 PMC6978796__F3 Roles of defective mitophagy in AD with a vicious cycle between them 142 1020 952 9958 84749 57558 10133 PMC6982102__F2 Ceramide is the central molecule in sphingolipid metabolism and can be synthesized by three different pathways: de novo synthesis pathway, sphingomyelinase pathway and salvage pathway 3791 1674 6611 64781 PMC6985464__F3 Molecular signaling in poultry feather follicle and feather development 324 2932 1499 595 6608 PMC6992650__F5 Kaposi sarcoma-associated herpesvirus infection pathway from KEGG 6773 637 465 2444 4863 8190 PMC6993408__F6 LSS-triggered VEGF-ATOH8 signal axis mediates CRC m-CTCs survival 4047 3099 2539 84913 PMC6996500__F6 Protein expression profile changes of lung tissue in patients with pulmonary hypertension 6443 1756 4634 4633 3479 PMC6996500__F7 Protein expression profile changes of lung tissue in patients with pulmonary hypertension 1756 6262 1832 1824 PMC6996500__F8 Protein expression profile changes of lung tissue in patients with pulmonary hypertension 1756 5350 4634 4633 4624 PMC6997398__F7 Pathological biological network construction of high calorie diet combined with pneumonia 868 6387 5465 51738 5617 6347 1401 3569 6720 3162 23411 284207 5660 7204 465 PMC6999456__F2 Sketches for DCA synthetic pathways 355 727 729 735 PMC7005498__F1 Cartoon Illustrating the UPR Pathway Involving Multiple Organelles and Three Branches, Several TFs, and Downstream Molecules Involved in Feedback Loops 22926 83939 468 PMC7007115__F2 Dietary Restriction 3479 7249 7248 6009 5465 PMC7015854__F2 Isolation of an archaeon at the prokaryote–eukaryote interface 1634 27294 11113 4118 PMC7019488__F4 Steamed bread and baked bread on the cytokine network (a) and central metabolic pathway metabolic network (b) 1950 3440 2597 PMC7020378__F9 Spatiotemporal metabolism in the apple fruit 2695 5183 443 PMC7023858__F3 IGFBP-3 was a predicted target of SAN by bioinformatics analysis 27040 619501 367 7157 3486 PMC7025433__F1 Methionine metabolic pathway 635 4548 27232 191 875 PMC7026856__F1 [U-13C6]-glucose metabolism in the brain 11113 2695 4118 PMC7029350__F8 Both extrinsic and intrinsic pathways converge in the same terminal execution pathway, which is initiated by the cleavage of caspase-3 8717 8772 581 PMC7039855__F1 Wnt signaling pathways 4920 4919 8658 324 5879 387 3725 607 2932 PMC7044062__F8 Changes in the urea cycle following LPS stimulation with or without DCA pretreatment 435 133 5009 PMC7047768__F1 Summary of transcriptional regulation of senescence in MSCs 9242 1021 1019 1017 3014 PMC7049061__F1 Bibliometric analysis flow chart of mTOR pathway in liver disease research 100187761 7054 8473 PMC7052306__F1 Activity-dependent synaptic plasticity at the Drosophila larval NMJ 4312 100188011 474168 PMC7054734__F9 CircNR3C1-Regulated Pathway in RPE CellsRed arrows indicate promotive function and green lines indicate suppressive function 6120 5728 2475 PMC7060546__F3 Roles of (P) RR in pathways that contribute to oncogenesis, as well as cancer progression and metastasis 183 4040 1636 324 1499 2475 PMC7062075__F5 KEGG metabolic pathway map showing significantly differentially expressed genes within the cytokine–cytokine receptor interaction pathway for hindgut control versus UCS 183 3977 3953 6295 1896 10913 5617 7173 4352 PMC7064563__F6 Metabolic pathways associated with EPS production in Phaeodactylum tricornutum 101448070 2444 4351 4693 2582 4350 PMC7072213__F2 Biogenesis mechanism of (a) exosomes and (b) MV, and their release processes which are coordinated through two different intracellular pathways, such as exosomes generation pathway and lysosomal degradation pathway 6386 5873 5874 11021 PMC7072466__F3 Expression profiles of key genes that are involved in the characteristic metabolite biosynthesis pathways in tea plants 435 8833 790 2638 PMC7072681__F1 Growth factors, such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF) bind receptor tyrosine kinases (RTKs) on the cell surface 1950 1956 2475 1019 PMC7072741__F10 Postulated differences in the CXCR4-LASP1-AKT1 signaling between breast cancer and CML 7852 2475 1399 6387 PMC7073561__F1 Lipid biosynthesis 2194 2581 6611 7357 PMC7073664__F7 Putative fatty acid synthase pathway of Thraustochytriidae sp 355 1356 100187761 1674 7054 PMC7074686__F1 Interplay of different signalling pathways that enable C 100187761 847 8473 PMC7090099__F3 Integrated analysis of GC-MS and LC-MS profiles 847 1636 1611 2695 PMC7105732__F1 “Four Hits” Hypothesis of IgA Nephropathy 7099 54106 51284 7054 PMC7106920__F1 Relationship between PCOS and immune cells 1638 3627 85451 920 PMC7107779__F7 Diagram revealing the impact of p62 on the initiation and development of tumors in prostate tissues through the Keap1/Nrf2/ARE pathway 9817 1728 2730 PMC7112240__F1 Drosophila-associated bacteria differentially shape the nutritional requirements of their host during juvenile growth 100187761 367 9049 PMC7116063__F7 Signal integration in the (m)TORC1 growth pathway 652968 83667 6009 153129 4864 83547 201163 PMC7120155__F11 Antifibrosis therapy 4018 2621 8205 2735 2444 2475 PMC7123108__F2 Cordyceps militaris adenine metabolic pathway 132 4907 100 4860 PMC7133421__F5 Graphical representation of the PI3K-Akt-mTORC1 signaling pathway 5728 7249 7248 PMC7139475__F5 Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea 3717 43 6774 847 4852 PMC7140485__F1 Canonical and non-canonical pro-fibrotic pathways of transforming growth factor B (TGFB) and Wnt and the pro-fibrotic interleukin 11 (IL-11) pathway 3589 2885 51199 PMC7140961__F3 Metabolic pathway based on phenolic profiling 65057 1312 790 PMC7143295__F2 Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway schematic representation of the Canonical Wnt Pathway and pharmacologic inhibitors of the Wnt/beta-catenin signaling pathway 2713 1499 23043 5091 PMC7149109__F1 Antiviral innate immune response 127882475 3588 7084 3716 7297 57506 4615 6773 6772 7187 7189 29110 3661 3437 325 PMC7149927__F9 Schematic diagram showing the effect of MG-infection on chicken thymus tissues 4615 7189 2475 114548 3553 PMC7155752__F3 Signal transduction in the early Drosophila follicle stem cell lineage 51715 6608 51684 PMC7156766__F5 Purine alkaloid metabolic pathway 4536 4537 353 PMC7176436__F1 De novo and salvage pathways of purine synthesis in eukaryotic cells 353 158 2766 8833 PMC7176765__F1 Multiple Lysine methylation regulate cellular functions of p53 80854 3276 57646 2695 56950 PMC7190945__F2 VSL#3 on intestinal barrier function 4280 920 2592 4023 6772 PMC7197765__F1 Cross-coupling reactions of benzylic C–H bonds and alcohols via a radical relay pathway 847 367 170302 PMC7199655__F1 Coupled-clock pacemaker system of the sinoatrial node 9575 759 847 PMC7199713__F1 Herbal medicine on the intrinsic pathway of apoptosis 324 331 1499 2475 581 595 4040 4041 PMC7209958__F1 Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants? 5447 210 3145 7390 7389 1371 5498 PMC7211213__F3 Therapeutic targets associated with activation of the Wnt signaling pathway 55366 8549 1499 324 7018 PMC7211589__F1 This figure illustrates the differential glucose metabolism in a healthy macrophage and in a COVID-19-activated macrophage 2475 5132 438 15 PMC7214542__F1 Regulatory and catabolic pathways for glucose and xylose metabolism in E 3250 1401 85569 5805 PMC7216182__F6a BST Stimulation Induces Atrophy and Changes in Aerobic Energy Metabolism in Rat Skeletal Muscles—The Biphasic Action of Endogenous Glucocorticoids 1325 847 3291 3290 PMC7218030__F3 Partial action pathways of H2S donors and their derivatives on TNBC 1499 94234 2475 842 836 PMC7226428__F1 Growth hormone (GH) on the vascular endothelium 2690 3717 6714 126669 2885 2689 PMC7226484__F2 L-cysteine metabolism 1491 7263 6821 4553 PMC7226514__F2 “Prion diseases pathway” from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database with genes significantly modulated in brain samples from ASD patients that have been color-coded from blue (downregulated) to red (upregulated) 64434 6761 1958 PMC7226770__F3 Blood–brain barrier, theoretically a motorway for a melting-pot of EXOs 4179 5873 5874 PMC7232103__F1 Proposed mechanism for the synthesis of dihydroindoles from triazole 1a and rationalization of dihydroindole regioselectivity from sigmatropic rearrangements 4397 129521 4827 4478 PMC7235771__F1 NGF and TrkA binding, just as BDNF and TrkB, leads to dimerization and autophosphorylation of receptors at tyrosine residues 4803 627 6010 PMC7241622__F1 Intracellular signaling pathways examined (A) and the experimental protocol used (B) 7038 5978 100653365 PMC7242365__F4 GWSS host support of nutritional metabolisms in Sulcia-GWSS and Baumannia 5212 79717 60490 80347 5053 7067 339896 7808 PMC7246647__F2 Oncogenic FGFR signaling in gastrointestinal stromal tumors (GISTs) 2249 10664 55107 PMC7247570__F3 Cross-talk of the mitogen-activated protein kinase (MAPK)/ERK signaling pathway and mechanism of cell death induction through the ERK-Hippo interplay 1956 2932 596 4170 836 PMC7249037__F7 KEGG pathway for breast cancer 5901 126669 5728 5426 100188776 7939 PMC7250321__F9 EV71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS accumulation 51 4094 571 PMC7250912__F1 Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways 4397 673 3845 PMC7260648__F1 Mechanisms underlying cytoplasmic organellar dysfunction after chemotherapy and melatonin's protective effects under these conditions 23410 847 3553 PMC7261776__F8 Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network, causing differences in pigment composition among mulberry fruits 2744 1431 4602 PMC7261837__F8 Anti-inflammatory responses of circumdatin D 4615 7189 3717 6774 PMC7264424__F8 Calcium signaling pathway 90550 5350 489 1356 2040 3270 2905 10345 613 PMC7273480__F9 Metabolic pathway analysis 6476 5891 126669 PMC7277093__F1 Role of CBS and other enzymes in the regulation of mammalian sulfur amino acid metabolism 4397 635 4524 875 1491 PMC7279331__F2 Key signalling events modulated by Ca2+/calmodulin and decisive for cell proliferation and survival 1956 3845 5894 2885 1839 PMC7281231__F7 Schematic representation summarizing the impacts of PEDV ORF3 on NFKB and IFNB signaling cascades 57506 29110 5970 3569 3661 3665 PMC7287096__F4 Schematics of EGFR degradation and recycling assays 1956 1950 4218 PMC7288675__F2 Regulation of the microbiota in adaptive immunity 920 7097 149233 PMC7289600__F3 ERK and tested pathways 1956 5909 5879 PMC7291237__F1 Late phase of the HIV-1 replication cycle 107966124 6667 6668 5091 PMC7317989__F1 Model illustrating the steps of EBV infection of epithelial cells 1969 8829 1380 PMC7319438__F1 SPEED2 application We manually selected pathway-specific perturbation experiments and estimated their pathway-relevance 7262 1839 9592 4170 1960 PMC7322178__F5 Metabolic impact of tyrosine kinase inhibitor (TKI) administration 1956 5979 2475 717 PMC7323084__F4 Rationale for targeting complement in COVID‐19 728 718 59272 PMC7330686__F3 Aromatic hydrocarbon in conjunction with CYP1B1 signalling pathway 5053 196 405 1545 PMC7332907__F2 Roles of FFA2 in immune cell populations 114548 163 6774 8178 3662 8854 7494 PMC7338763__F1 What Matters for C4 Transporters: Evolutionary Changes of Phosphoenolpyruvate Transporter for C4 Photosynthesis 100187761 1431 5183 2638 4118 PMC7341904__F1 Upregulation of the MAPK pathway in tumor cells leads to proliferation and progression of thyroid cancer 5979 673 2475 940 6752 PMC7343448__F10 Mechanism of Sirt1 associated Adriamycin-resistance in DLBCL cells 23411 4535 4541 7019 PMC7348182__F7 Results of RT‐qPCR and ELISA validation for cAMP and Rap1 signal pathway 641 111 107 114 PMC7348939__F1 Fundamental aging mechanisms that contribute to sarcopenia 4976 55669 9927 PMC7349634__F1 Pathways of synthesis of oxylipins from Eicosapentaenoic acid (EPA) and ARA PUFAs 2717 4015 26136 PMC7352172__F1 NAD+synthesis pathways 952 203447 10135 PMC7352595__F9 Biosynthesis pathway of phenylpropanoid in P 1312 790 1236 PMC7360727__F2 Insulin signaling with highlighted in red pathways found to promote brain insulin resistance in AD and DS 3667 2475 351 PMC7366512__F1 Biomaterial-triggered complement activation drives early thromboinflammatory changes during hemodialysis 728 718 3553 7018 717 716 2271 PMC7369697__F1 BRAF signaling pathway including abnormal signaling from BRAFV600E mutated proteins 673 369 572 PMC7377858__F6 circRNA-miRNA-mRNA network 10210 55137 324 2922 1325 8833 339745 85004 PMC7378251__F3 Expression of genes related to starch and sucrose metabolism, glycolysis, TCA cycle and amino acids pathway under CK, MD, AT and SD 47 440 1738 PMC7381633__F6 Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway 26031 3091 6010 PMC7383044__F1 Activated c-Mpl dimer leads to activation of multiple signaling pathways which promote proliferation and platelet production 4352 4351 3717 2885 PMC7391499__F5 Lignin biosynthesis pathway and monolignol biosynthesis related gene expression in P 790 1312 1611 PMC7393405__F1 Activation of the Main Innate Immune Receptors Involved in CVDs(A) Toll-like receptor (TLR) signaling pathway 114548 10392 64127 8767 4615 PMC7397839__F1 Metabolic Role of PTEN in Insulin Signaling and Resistance 5728 2475 2885 PMC7400212__F1 In (A): Interactions of methionine cycle, folate cycle, transsulfuration and methylation pathway 4524 5212 2356 PMC7400404__F11 Complexin 2 in green box was mapped onto the synaptic vesicle cycle pathway (04721) generated by KEGG PATHWAY (Organism: Danio rerio) 6651 100170220 8205 6855 PMC7404778__F2 Graphical representation of the mechanism of action of bioactive compounds on the antioxidant and immune response 9817 4353 4094 7124 847 PMC7407119__F2 The antioxidative landscape in the cell, and the corresponding modulators of key players 2937 2936 2810 84565 9817 7295 PMC7426575__F5 Schematic Model for Major Immune Escape-Initiating Domains and Immune Escape Points in Tumor-T Cell Interaction(A) Major immune escape points depicted in schematic model, highlighting tumor-T cell interaction at last stage of cancer-immunity cycle 3458 4283 2833 PMC7428719__F1 Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders 847 1728 2475 PMC7429633__F2 Pathway to protein phosphorylation and cysteine modification of sarcoplasmic reticulum Ca2+ handling proteins 1356 6262 5350 PMC7432774__F1 Biology of tumor hypoxia 2475 22926 7494 468 PMC7437582__F1 New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target? 1499 6259 5754 324 847 PMC7438890__F1 Effect of local RAS on normal and leukemic hematopoiesis, as well as plasticity and systemic circulation, are shown () 183 367 1636 2973 5476 6770 59330 PMC7439920__F3 Critical role of HGMB1 in the complex interplay between apoptosis and autophagy 3315 3146 6009 9140 PMC7443474__F3 Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential 5728 7249 7248 3480 PMC7445374__F2 Contact system in disease states 2 720 716 715 717 5340 PMC7448569__F6 Gene expression profiles of the IL-17 signaling pathway in the breast cancer group 5966 8772 7054 100187761 6955 8178 3558 PMC7456945__F6 Simplified metabolic network indicating major pathways of volatile organic compound (VOC) synthesis and associated CO2 decarboxylation processes in the light 5183 5132 3652 4015 PMC7460532__F1 Phosphatase and tensin homolog (PTEN) signaling pathway and its interactions 717 7157 5728 2475 PMC7460550__F2 Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population 1356 5578 2308 10309 3458 PMC7461825__F1 Role CRP on the innate immune system and tumor progression 1401 5728 2475 PMC7464394__F3 Glutamatergic synapse pathway and expression levels of sea lice exposed to three drugs 65057 2744 4149 PMC7472658__F6 Clinical implications of PTEN loss in prostate cancer 3667 5728 7249 7248 2475 6009 253260 PMC7476343__F1 Representation of the reciprocal links between cancer and thrombosis 847 324 5091 7018 7450 PMC7478739__F6 SOAT1 abrogates cholesterol feedback inhibition to promote mevalonate pathway dependency in PDAC 3949 6010 6646 3156 PMC7483885__F2 Pathway map for the production of terpenoid compounds 11113 4118 3652 PMC7488355__F3 Association between Alcohol Use Disorder and manifestation of Alzheimer’s disease (AD) 2932 1020 2475 PMC7497240__F2 A) Comparison of the putative biosynthetic gene cluster (BGC) of tjipanazole biosynthesis in F 6769 7082 9414 PMC7497778__F2 Functions of HSCARG in the cytoplasm 7124 8717 7874 7187 3661 847 435 7186 PMC7502477__F3 Chemical Structure and Biosynthesis of NAD+ 10135 93100 23475 PMC7504917__F2 Endogenous production of H2S and cross-talk between H2S/RSS and ROS/RNS in bacteria 875 4397 847 4810 140821 PMC7530640__F1 Role of microglia and canonical NLRP3 inflammasome in Alzheimer's disease 114548 3146 79792 3553 PMC7531533__F1 Schematic showing how retinoids regulate thermogenic gene expression in adipocytes 64220 7350 155 PMC7532371__F4 Biological process crosstalk among CMTgset-enriched biological processes 100187761 5624 1674 PMC7533603__F4 Modeling the metabolic modifiers of T-cell function in Tconv and Treg, showing differential impacts of glycolysis and oxidative phosphorylation on each and the role of the mTOR pathway in mediating this 940 57521 50943 PMC7539770__F3 Influence of the SRSF1 splicing factor on malignancy through AKT signalling 7248 7249 6009 1977 PMC7540572__F1 Tricin biosynthetic pathway from the key pathway‐branching intermediate, p‐coumaroyl‐CoA, with generic enzymes in grasses noted in green (Lam et al., ; Eloy et al., ), and in red are those from Medicago sativa (Ms) and M 412 2152 790 PMC7563732__F4 Enzymes from the purine salvage cycles identified in the L 9615 353 2766 8833 435 PMC7564048__F3 Crosstalk with the TGFB/BMP SMAD pathway at focal adhesions (FA) 659 2022 7939 PMC7564532__F4 Hypothalamus-pituitary-gonad (HPG) axis in vertebrates and related molecular pathways 181 4852 6866 5617 51083 2798 3973 2492 PMC7564754__F3 Selected polyphenols that interfere with p27 expression and activity (see and text for details) 6714 1017 1027 PMC7564838__F1 The metabolic pathway for MA biosynthesis in E 1431 6608 84890 PMC7565564__F2 Examples of molecular mechanisms underlying the effects of uremic toxins on various cells, with focus on the aryl hydrocarbon receptor signaling (AHR) pathway 4942 196 6714 7018 PMC7570648__F2 Each herb in fighting cancer through oxidative stress pathways 847 5728 3091 PMC7578900__F7 Signal pathway of PIO on mitochondria‐mediated apoptosis in cisplatin nephrotoxicity 4280 23411 581 PMC7580956__F4 Carbon metabolism in the plastids of E 51684 2242 2597 367 22934 6120 283871 PMC7582838__F2 Modified tricarboxylic acid (TCA) pathway in cyanobacteria 4397 5132 5183 PMC7583029__F1 Plant abiotic stress perception and response, concerning different cell compartments/organelles, and the terpenoid biosynthesis pathway 759 4342 9961 6395 4597 3652 PMC7589301__F1 The possible molecular mechanism of amantadine’s antidepressant effects at the level of dopaminergic and glutamatergic transmission 1644 4129 627 PMC7590081__F1 Catabolic pathways regulating TG levels in cells 7038 80339 355 PMC7590900__F1 CXCR3 signaling pathways in different cell types 4283 3627 6373 2833 51071 4280 790 100187761 9118 PMC7599682__F2 SRC structure and regulation 7448 1956 2475 6774 PMC7599912__F3 Metabolic Pi sensing in mammals (modified from ) 846 10818 2885 9807 80763 PMC7599957__F1 Network diagram of the model 39 4598 10654 3949 4597 3652 2224 PMC7599984__F4 Hedgehog signaling pathway 6608 51684 2736 91653 PMC7601404__F1 Arginine biosynthesis 162417 55577 435 PMC7604572__F1 ATP drives ATPase pump, membrane potential and Hh patterning 11319 2597 4026 6608 PMC7641192__F3 Calcium signalling pathway (map04020) obtained from KEGG database with official permission and guidance from Kanehisha Laboratories (permission ref 200,290) 90550 5350 859 613 PMC7642854__F3 Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling 3630 3667 5266 7499 5728 PMC7643606__F2 Leishmania spp.-induced activation of the NLRP3 inflammasome 6850 114548 79792 3553 PMC7653775__F7 An overview of homocysteine metabolism and the transsulfuration pathway 10400 191 1103 875 1491 PMC7656798__F1 PI3K/AKT/mTOR signaling pathway in cancer 5728 7249 7248 2475 PMC7662426__F3 Molecular signaling pathway of PA28G in cancer 23411 4193 1616 9232 PMC7667085__F1 Pseudomonas aeruginosa injection (PAI) make the naïve T cell mature through both CD80/86 and MHC-II signal pathway in dendritic cells (DC) 940 941 942 PMC7669588__F2 Pathway for Nucleotide Excision Repair (NER) 7508 7507 5111 PMC7670425__F3 Critical roles of FAM134B in ER-phagy and diseases 619501 367 55504 PMC7671463__F3 Cell signalling influences immune response and resistance to immunotherapy 3458 1499 2475 PMC7672213__F6 Potential apoptotic pathway for anticancer effects of RPL against lung cancer 1103 100187761 56616 472 PMC7677142__F1 Subcellular localization of the cholesterol biosynthetic pathway in mammalian cells 570 404713 3638 22937 PMC7685642__F3 Resveratrol, curcumin and paclitaxol affects the mTOR pathway at several stages from inhibition to PI3K to suppression of Akt signaling to prevent the mTORC1 and mTORC2 complexes 5728 6009 7248 7249 2475 64798 PMC7689683__F1 Signaling pathways of three estrogen receptors 1956 1839 6714 2885 2002 PMC7693344__F1 Metabolic enzymes associated with glycolysis and the pentose phosphate pathway, depicted here, serve as critical regulators of inflammatory responses in myeloid and lymphoid cells 2475 5315 4609 PMC7693462__F6 NAA as a selective, alternative cytoplasmic and nuclear acetyl-CoA source 443 339983 23152 55902 47 PMC7693799__F5 Molecular enrichment networks of genes associated with diabesity and the cluster 1 network enrichment analysis 100 213 1475 3371 1356 2520 100187761 PMC7694322__F1 Melatonin biosynthesis and intracellular signal-transduction pathways activated by stimulation of melatonin specific receptors 438 2638 4504 PMC7696079__F2 Underlying mechanisms of LND-mediated antitumor activity 2539 2936 581 6391 6392 6389 PMC7697203__F14 Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications 5066 1431 5539 PMC7702481__F5 Dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs 4151 2638 5091 965 PMC7714782__F1 Response of methionine metabolism in the liver 4548 635 875 PMC7720132__F6 Summary of major impacts of challenge with Vibrio coralliilyticus RE22 and probiotic treatments with Bacillus pumilus RI06–95 and Phaoebacter inhibens S4 on Crassostrea virginica larval immune responses 7189 8195 847 79065 PMC7723172__F3 Effects and mechanisms of corosolic acid-induced anti-inflammatory and anti-MS activities 4397 114548 3667 PMC7728579__F2 Transsulfuration and H2S oxidation pathways 6821 875 7263 23474 717 PMC7731198__F4 Novel mechanism of lysostaphin resistance in ST72 isolate and its associated metabolic pathway 1725 1719 4397 4524 191 875 PMC7734804__F1 Initial establishment of anti-viral state via innate immune responses to DENV infection 4615 29110 57506 115004 7187 3661 3665 7189 PMC7744508__F1 Central carbon metabolism network, which was implemented in the multi-level kinetic model of Synechocystis 183 25801 3250 7086 1896 2821 PMC7747089__F1 Induction of type I IFNs and ISGs by influenza virus 8638 64127 3716 7297 9023 57506 6773 6772 4615 3659 3661 3665 PMC7753017__F4 Four pillars of sarcoidosis model 472 2475 28755 929 54210 PMC7753360__F1 Lipid metabolism overview in normal and cancer cells 355 4023 47 3156 3949 7436 PMC7756379__F5 Proposed pathway for gladiostatin biosynthesis 4397 5966 275 PMC7764203__F5 Metabolic pathways involved in lactate-based or ethanol-based chain elongation and production of acetate, n-butyrate, iso-butyrate, and n-caproate as predicted from the genome annotation of strains BL-3, BL-4, and BL-6 100 2108 2109 PMC7764760__F2 An EGFR-centric view of EV biogenesis 1950 2885 1956 1356 367 PMC7774019__F8 EBV early protein BFRF1 inhibiting RLR-mediated IFNB signaling pathway 7187 29110 3661 PMC7775471__F3 NAD+ biosynthesis pathways 93100 203447 23475 130013 55191 10135 PMC7784996__F3 Metabolism of Methylophaga aminisulidivorans SZUA-1124 49 10763 6476 6395 PMC7795003__F2 IGF-1 receptor, insulin receptor and hybrid receptor 3479 3480 2475 PMC7795003__F3 Interplay of GH, IGF-1, insulin, hybrid receptor and nutrients in the muscle 3479 3717 153129 2475 PMC7799431__F1 Importance of Keeping Time in the Liver 10135 406 23411 51548 9575 6095 PMC7802442__F4 Case of UDP-Galactose 4′-Epimerase Deficiency Associated with Dyshematopoiesis and Atrioventricular Valve Malformations: An Exceptional Clinical Phenotype Explained by Altered N-Glycosylation with Relative Preservation of the Leloir Pathway 51083 101448070 2592 7360 2582 PMC7806659__F10 The proposed hypothesis model showing that miR-148a-3p positively regulates neuronal apoptosis via activating the PI3K-AKT signaling pathway by targeting SYNJ1 8867 2475 572 842 PMC7816678__F3 Diversity in stimulus sensing, fuel sources, and thermogenic mechanisms of brown and beige adipocytes 367 948 8140 9673 7038 7350 1734 PMC7817624__F1 Metabolic pathways in breast cancer cells 3091 4609 5315 3939 2475 2194 47 2744 6510 PMC7824611__F4 Diphthamide synthesis and ADP-ribosylation 1938 1801 1802 285381 51611 PMC7825432__F3 Glycolysis reactions and the reactions of encapsulated enzymes (GDH + AAT) in erythrocyte 2821 1611 2597 PMC7828713__F1 Effectors of microglia function associated with neurodegeneration and how microglia damage or kills neurons 203228 54209 3064 PMC7836502__F6 Production of PA and DGPP by different pathways and interconversion reactions mediated by phosphorylation and dephosphorylation 4018 759 761 5091 768 766 767 771 4952 5266 PMC7838196__F8 PI3K-AKT signaling pathway 2475 5894 5879 613 6850 930 5728 572 4602 PMC7840310__F6 Cell cycle program in cell death and metamorphosis 1101 4313 7448 4318 7450 4320 4322 4323 960 948 961 PMC7840718__F2 Growth factors stimulation induces the PI3K/Akt/mTORC1 pathway 7249 7248 6009 PMC7843495__F3 Mitochondria-related core genes and TF-miRNA-hub mrDEGs network in breast cancer 7054 367 3991 PMC7843791__F2 Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer 23269 2774 8473 10724 5723 PMC7848146__F2 Signaling pathway and mechanism related to lung cancer driver gene in brain metastasis 5728 6935 1499 2475 PMC7849055__F5 Diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence 948 3667 5728 208 2932 PMC7855922__F1 PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective 1443 2475 673 5728 PMC7863362__F5 Expression changes of central carbon and energy metabolic pathways 7956 2597 1431 2821 2875 PMC7864012__F2 One-carbon metabolism around the folate cycle, methionine cycle and trans-sulfuration pathway 2731 1719 4524 635 4548 875 1491 PMC7864954__F6 miR156-based regulation of SPL13 enhances photosynthesis, phenylpropanoid, and ABA biosynthesis in response to flooding 5183 4602 5091 2641 PMC7867633__F1 Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes 4899 27343 11201 7019 5442 PMC7868569__F10 Chrysophanol-mediated suppression of the inflammatory response 3146 3553 8841 PMC7870078__F5 Identification of differentially expressed genes involved in amino acid and lipid accumulation of winter turnip rape (Brassica rapa L.) in response to cold stress 4942 10157 189 PMC7870784__F4 Depiction of MAPK signaling pathway dysregulation and miRNAs in the KEGG database 3480 238 4763 8190 PMC7872968__F5 HIF-1 signaling pathway and (B) relaxin signaling pathway in lungs 2475 6774 1977 3091 4318 4313 59350 PMC7882174__F2 Role of leonurine in cardiovascular disease 1356 8213 572 2475 PMC7885873__F1 Cytokine regulated alterations to the splenic microenvironment during experimental visceral leishmaniasis 7124 4915 1236 639 6366 6363 10563 6955 3902 6387 PMC7890028__F1 Wnt signaling pathways and their modulation by pharmacological molecules 6259 324 1499 PMC7892431__F1 RNA sensing and viral manipulation of TLR and RLR signaling pathways 57506 29110 841 4615 3661 3665 114548 PMC7895386__F5 Wide range of metabolic adaptations to the acquisition of the Calvin cycle revealed by comparison of microbial genomes 7086 1896 4118 5183 11113 PMC7906391__F5 Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease 351 8455 3033 PMC7907040__F2 Major signaling pathways of GPCR subfamilies 5225 367 1499 PMC7911501__F1 TLRs are involved in regulation of Mycobacterium tuberculosis (MTB)-induced production of proinflammatory cytokines 54106 7097 7099 54472 PMC7916160__F2 Overview of phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR signaling pathway and inhibitors 3667 5163 5728 6009 1977 PMC7917105__F4 Genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume 6476 790 1312 PMC7917554__F4 Key features of different forms of regulated cell death 142 4282 2879 PMC7918761__F1 Methionine cycle facilitates re-methylation of homocysteine to methionine via methionine synthase (MTR) and betaine-homocysteine S-methyltransferase (BHMT) enzymes 4548 4552 635 27232 875 191 1491 PMC7920551__F8 Model depicting lymph gland progenitor heterogeneity and response to immune challenge 27040 100653366 100188011 7015 PMC7923825__F1 Engineered (S)-linalool biosynthetic pathway in P 4598 4597 3652 PMC7938726__F1 Diagram of osteoimmunology and potential regulatory sites of TCPTP 920 10113 6387 PMC7945216__F7 Mechanism graph of the regulatory network and function of FoxM1-mediated miR-335-3p in NSC self-renewal 2332 1017 1019 2305 PMC7953864__F6 Signaling pathway of MBHD-VD PPI network (blue and pink circles stand for compound target and VP genes, resp; red diamond stands for pathway; green hexagon stands for herb) 4852 2475 3727 3791 6850 7018 6714 355 54205 867 3725 4049 4803 PMC7961611__F1 Transsulfuration pathway (TSP) and related pathways 4397 635 27232 4524 875 3242 PMC7961611__F2 Hydrogen sulfide production pathways 847 875 4357 PMC7975969__F2 Nutrient effects in activation of mTOR system and the end-organ results 3667 5163 2475 6009 64798 PMC7983599__F1 Effect of Thyroid Hormones on Adipose Tissue Flexibility 7200 367 7216 6957 1374 PMC7984366__F2 Endogenous estrogen regulates the proliferation and differentiation of NSPCs 1956 2852 6714 PMC7990354__F1 Molecular mechanisms of renal aging 3553 183 2932 324 6098 4040 4041 PMC7996755__F3 Nrf2 signaling in mediating DOX resistance of cancer cells 960 4018 6722 PMC7996784__F2 Mevalonate and methylerythritol 4-phosphate pathways in Cannabis sativa 4200 4597 3652 PMC7997823__F1 Signaling pathways of the main cytokines involved in cardiovascular diseases 3554 3553 8717 7186 126669 PMC7998429__F3 Nail organ markers and the requirement of the bone morphogenetic protein (BMP) signaling in proper nail development and differentiation 4014 59352 22822 PMC8001445__F4 Metabolomic map of flor yeast gluconic acid consumption 2695 5091 11113 4118 PMC8002743__F6 Detailed schematic models representing changes in cellular processes with CdSe/ZnS QDs or InP/ZnS QDs in the budding yeast 619538 100187761 4553 PMC8004207__F17 Schematic diagram showing the effect of prenatal exposure to VPA on the pathological changes in the brains of young-adult male offspring 7249 6009 7248 PMC8005514__F3 PI3K/AKT pathway and HER2-targeted therapy resistance 3480 4585 5728 2475 PMC8006921__F7 Wnt signaling gene expression profiling in healthy versus asthmatic bronchial fibroblasts generated by PathViso pathway analysis and drawing software 3630 5447 387 8000 4773 2353 5328 PMC8007787__F1 Reverse transsulfuration pathway and inputs from associated pathways 5212 4397 635 4524 875 847 PMC8024566__F1 CCR7 and the reactive LN 613 1236 6363 643 6366 10563 PMC8034456__F8 The beneficial effects of FGF19 on muscle atrophy, metabolic homeostasis and irisin secretion in skeletal muscle 9965 7350 4656 3667 7019 4899 PMC8034969__F8 JAK-STAT signaling pathway and other related signaling pathway as well as the mechanism of the function of inhibitors identified in this study 1950 3717 2475 PMC8035078__F1 LTA synthesis, models for the cross-membrane d-alanine modification process and examples of WTA and complex SCWP synthesis pathways 4049 2973 51083 PMC8037590__F2 Insulin-mediated feedback loops following PI3K/mTOR inhibition 2885 5163 2475 64798 5728 6194 1977 PMC8039545__F7 Visualization of the differential gene regulation in PBMCs responding to A 2078 367 5966 6418 PMC8043969__F1 Germline Variants that Affect Tumor Progression 2885 23152 54715 1521 23451 5728 2767 5290 2475 PMC8046925__F6 Visual pigment cycle reactions in vertebrate and invertebrate photoreceptors: (A) Pathways for visual pigment regeneration in the vertebrate retina, including both the classical and non-classical pathways 6120 5995 9227 PMC8047476__F1 Psoriatic arthritis is a multifactor disease 7099 4615 6774 149233 PMC8055737__F1 ESCAPE-NA1 Trial Brings Hope of Neuroprotective Drugs for Acute Ischemic Stroke: Highlights of the Phase 3 Clinical Trial on Nerinetide 847 100187761 5340 PMC8056677__F7 Calvin (left) and C4-Dicarboxylic acid cycle (right) in S 5183 7086 2597 6120 PMC8065217__F1 Spatiotemporal regulation of hydrogen sulfide signaling in the kidney 875 847 1610 PMC8065760__F3 Involvement of the significantly dysregulated microRNAs in renal cancer signaling pathways 407009 7428 2475 1956 1950 406984 PMC8068500__F2 Bioengineering strategies to control epithelial-to-mesenchymal transition for studies of cardiac development and disease 7490 6722 1499 PMC8071856__F1 Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk With Nitric Oxide 23411 10135 7019 4899 PMC8079762__F1 Targeting Solid Tumors With BTK Inhibitors 695 4193 572 PMC8080617__F3 Active D-secretase is the trigger for both AD and PD 6733 4129 217 PMC8081888__F4 Metabolic Landscape for Maintaining Retina Integrity and Function 6120 4118 3945 PMC8085316__F2 Adapting T Cell Receptor Ligand Discrimination Capability via LAT 3932 27040 100187761 PMC8085478__F1 Sclerotic chronic GVHD: you may WANT to block WNT 324 4040 1499 PMC8087485__F1 Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine 100187761 1571 619501 8213 PMC8087567__F1 How the love of muscle can break a heart: Impact of anabolic androgenic steroids on skeletal muscle hypertrophy, metabolic and cardiovascular health 367 1956 3667 PMC8087698__F1 Serine synthesis pathway (SSP) and downstream anabolic pathways 26227 29968 5723 PMC8087812__F2 Response of green leaf volatile (GLV) biosynthesis in MeJA-primed fresh tea leaves 4015 217 4397 PMC8093614__F1 PD-1 Immune Checkpoint Inhibitor Therapy Malignant Tumor Based on Monotherapy and Combined Treatment Research 324 940 942 PMC8095380__F7 Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology 5290 3265 9241 572 6095 1147 4117 4602 PMC8097461__F6 Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin 2353 3652 1984 11113 4118 PMC8107084__F6 MiR‐155 promotes colitis‐associated intestinal fibrosis by targeting HBP1/Wnt/B‐catenin signalling pathway 26959 324 1499 PMC8107678__F1 Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease 7189 4615 114609 PMC8117212__F3 Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response 3661 4615 7099 6774 PMC8117532__F6 Role of chimeric genes in pathway-related gene co-expression modules 7054 324 920 PMC8135047__F1 Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis 6651 9118 100187761 PMC8136793__F3 Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication 201973 1652 5111 PMC8138161__F6 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway 2475 7099 771 PMC8139735__F11 An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia 126669 7018 596 3880 PMC8144126__F9 Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease 4615 7099 929 7038 5465 PMC8146326__F8 Extracellular Vesicle Release Promotes Viral Replication during Persistent HCV Infection 387 382 9475 6093 PMC8150642__F1 KRAS, A Prime Mediator in Pancreatic Lipid Synthesis through Extra Mitochondrial Glutamine and Citrate Metabolism 3725 2353 4609 2475 3091 PMC8151307__F10 Quo vadis Cardiac Glycoside Research? 1956 6714 2885 PMC8152475__F9 Multi-Functional MPT Protein as a Therapeutic Agent against Mycobacterium tuberculosis 340451 29110 3661 3099 PMC8161229__F3 Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis 2175 7054 4099 PMC8163825__F2 Key metabolic pathways in Hermodarchaeota genomes 4942 50853 7429 4118 175 PMC8169546__F1 The Protective Mechanisms of Paeoniflorin in Neurological, Cardiovascular, and Renal Diseases 1956 6774 9817 PMC8170419__F3 Intersectional analysis of chronic mild stress-induced lncRNA-mRNA interaction networks in rat hippocampus reveals potential anti-depression/anxiety drug targets 100187761 4201 6476 126669 4975 1103 PMC8170687__F1 Integrin function is regulated by conformational activation and vesicular traffic and is crucially involved in mechanosensing and TKR signaling 23062 5872 960 PMC8170847__F2 Developmental Pathway and Interconnectivity of Immunotherapy and Nanotechnology: 594857 8205 325 PMC8174708__F1 Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies 5723 4552 4524 1491 875 4397 435 PMC8176847__F2 Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications 8772 836 581 PMC8188603__F7 Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy 183 5091 7124 759 351 PMC8194072__F3 Pleiotropic Roles of CXCR4 in Wound Repair and Regeneration 9242 7852 3712 PMC8194268__F1 Mesenchymal Stem Cell Protects Injured Renal Tubular Epithelial Cells by Regulating mTOR-Mediated Th17/Treg Axis 9242 6009 920 2475 6774 PMC8197226__F1 Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis 4478 2353 3725 11221 PMC8198168__F2 Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer 100996569 2475 4609 2146 55818 7403 23081 2744 PMC8198195__F5 Resolving the Contradictory Functions of Lysine Decarboxylase and Butyrate in Periodontal and Intestinal Diseases 3045 100187828 79944 PMC8198876__F1 Targeted Therapeutic Approach Based on Understanding of Aberrant Molecular Pathways Leading to Leukemic Proliferation in Patients with Acute Myeloid Leukemia 51684 3717 2475 6608 54790 945 581 PMC8200290__F4 Up-regulated genes in advanced basal cell carcinoma overlaid on the KEGG “extracellular matrix–receptor interactions” pathway 1101 7450 960 948 961 PMC8204019__F1 Radiation Resistance: A Matter of Transcription Factors 6774 3717 6772 4582 PMC8216287__F4 Multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity 672 29128 472 PMC8220701__F1 Genome-wide expression and network analyses of mutants in key brassinosteroid signaling genes 54861 51411 578 4149 PMC8222790__F4 Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML 55364 7054 6770 4827 PMC8224422__F2 Synthetic Formatotrophs for One‐Carbon Biorefinery 2147 51083 2875 4049 3034 PMC8224569__F6 Global Transcriptional Response of Aspergillus niger to Blocked Active Citrate Export through Deletion of the Exporter Gene 847 3938 1431 11113 4397 PMC8224798__F2 Harnessing the Physiological Functions of Cellular Prion Protein in the Kidneys: Applications for Treating Renal Diseases 2475 387 100616258 7018 PMC8226009__F4 N6-Methyladenosine RNA Methylation Regulator-Related Alternative Splicing (AS) Gene Signature Predicts Non–Small Cell Lung Cancer Prognosis 51701 79858 3075 9643 5805 27343 3845 2017 7054 2077 1384 3155 351 2534 5371 PMC8226072__F1 Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research 1723 790 2618 7808 7372 4975 10606 158 471 8833 PMC8226851__F4 SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants 10379 59272 3661 3665 7098 51284 PMC8230717__F3 Genetic Susceptibility to Periodontal Disease in Down Syndrome: A Case-Control Study 666 2056 572 759 PMC8232269__F4 One Hundred Candidate Genes and Their Roles in Drought and Salt Tolerance in Wheat 5091 7018 4015 PMC8233448__F1 NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies 114548 140609 3553 PMC8235326__F2 Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma 84876 6786 6275 664 572 7038 90550 PMC8235519__F8 Comparative Analysis of Flavonoid Metabolites in Foxtail Millet (Setaria italica) with Different Eating Quality 4828 23531 268 PMC8237035__F1 SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19 1636 7054 1191 100187761 5132 PMC8243607__F6 Transcriptomics identifies key defense mechanisms in rice resistant to both leaf-feeding and phloem feeding herbivores 100187761 2077 4602 PMC8245769__F1 Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles 4862 875 8864 PMC8246373__F2 Activity-Dependent Gene Expression in Neurons 5447 5091 387 7018 PMC8253836__F1 Consolidated bioprocessing for bioethanol production by metabolically engineered Bacillus subtilis strains 5805 7851 5132 PMC8256842__F8 13-Gene Metabolic Prognostic Signature Is Associated With Clinical and Immune Features in Stomach Adenocarcinoma 126669 1081 4099 3976 3630 6651 PMC8266488__F3 Sex Hormones and Gender in the Gut Microbiota 6714 7018 6667 PMC8268312__F1 Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators 59272 7113 51284 51311 4615 57506 3661 PMC8273435__F4 The F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases 9050 9051 1445 PMC8277576__F5 Steroids on T lymphocytes 326 940 50943 PMC8277969__F3 Metabolic reprogramming in cancer: mechanistic insights from Drosophila 1956 8473 4609 23513 474168 1445 PMC8281578__F1 Neutrophil extracellular traps in cancer: not only catching microbes 4353 7097 7099 PMC8283099__F5 Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitude 282617 101180976 2539 2936 PMC8286267__F7 HBcrAg species, biogenesis, and application as biomarkers to monitor HBV gene expression and replication during natural resolution 3972 619511 6461 PMC8286568__F5 Bacterial alginate metabolism: an important pathway for bioconversion of brown algae 5132 351 3652 PMC8289871__F10 Cartoon depicting the putative molecular mechanism for insulin protection of pancreatic acinar cells during acute pancreatitis 2147 100 2717 PMC8291708__F1 De novo purine synthesis (DNPS) pathway 2618 7808 10606 158 353 8833 PMC8291901__F2 Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment 100379198 28 2582 23411 5225 PMC8294160__F4 Oxyresveratrol Modulates Genes Associated with Apoptosis, Cell Cycle Control and DNA Repair in MCF-7 Cells 4342 2669 2040 PMC8301030__F1 Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans 3008 5805 406905 PMC8301219__F3 Immune Checkpoint Inhibitors in Human Glioma Microenvironment 7054 4280 51083 PMC8302727__F2 Proposed biosynthetic pathway of ARTs based on the two-polyketide-chain assembly model 387569 1636 420 PMC8304138__F2 Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies 7276 64220 1592 PMC8304577__F9 Analysis of Phytohormone Signal Transduction in Sophora alopecuroides under Salt Stress 5162 5132 23743 1491 1737 445347 3156 4598 1121 10682 4597 2597 1674 PMC8304747__F2 Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second Alteration 445 435 3939 2194 47 2744 PMC8306961__F2 Arginine Signaling and Cancer Metabolism 6009 153129 5163 222545 PMC8307213__F6 Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis 4976 55669 65018 283514 PMC8313979__F2 Systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis 7018 1869 6480 PMC8330049__F1 Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies 847 2885 6714 4763 5350 PMC8333862__F1 NAD+ Homeostasis in Diabetic Kidney Disease 93100 10135 23475 PMC8334720__F1 Interplay Between mTOR and Hippo Signaling in the Ovary: Clinical Choice Guidance Between Different Gonadotropin Preparations for Better IVF 6194 3491 894 PMC8343065__F1 Cell Cycle Commitment and the Origins of Cell Cycle Variability 1021 1019 4609 1017 PMC8348138__F5 Transcriptome-Based WGCNA Analysis Reveals Regulated Metabolite Fluxes between Floral Color and Scent in Narcissus tazetta Flower 5447 717 718 3652 PMC8349595__F4 Nutrition, One-Carbon Metabolism and Arsenic Methylation 5091 4397 635 10400 2548 57412 2593 4548 6573 4524 PMC8351231__F1 Different signaling pathways involved in resistance to EGFR tyrosine kinase inhibitors (TKIs) driven by Protein Kinase C delta (PKCD) and receptor tyrosine kinase recycling 1956 1314 64866 2241 5784 PMC8351524__F9 Apolipoprotein C‐II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway 2638 4397 2022 4318 4313 PMC8353268__F4 Quantitative developmental biology in vitro using micropatterning 9241 4838 256933 PMC8353397__F10 Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis 7535 8717 4803 3065 3066 4049 PMC8354137__F1 Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay 65018 55486 4397 131474 PMC8359813__F1 Improving the Production of Riboflavin by Introducing a Mutant Ribulose 5-Phosphate 3-Epimerase Gene in Bacillus subtilis 7086 6120 5640 PMC8371345__F1 Thyroid hormones and the potential for regulating glucose metabolism in cardiomyocytes during insulin resistance and T2DM 948 95 5091 PMC8379279__F1 Model assumptions 7075 387 5728 6714 PMC8380940__F1 Engineering Biological Electron Transfer and Redox Pathways for Nanoparticle Synthesis 4149 410 411 PMC8386298__F2 Moving Towards Targeted Therapies for Triple-Negative Breast Cancer 2475 5728 367 PMC8389183__F5 Recent ecophysiological, biochemical and evolutional insights into plant carnivory 7018 5640 22944 PMC8391210__F3 Follistatin-Like Proteins: Structure, Functions and Biomedical Importance 4088 4087 7124 3383 2475 2308 9961 PMC8392360__F1 PI3K/Akt Pathway: The Indestructible Role of a Vintage Target as a Support to the Most Recent Immunotherapeutic Approaches 2475 3458 5728 PMC8394875__F4 Ovarian Cancer and Cancer Stem Cells—Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology 595 648 4609 960 PMC8396838__F5 Comparative Transcriptome Analysis Reveals bmo-miR-6497-3p Regulate Circadian Clock Genes during the Embryonic Diapause Induction Process in Bivoltine Silkworm 1407 1629 1408 PMC8403061__F6 C-Type Natriuretic Peptide Plays an Anti-Inflammatory Role in Rat Epididymitis Induced by UPEC 1267 3553 8161 PMC8424549__F7 Regulation and metabolic functions of mTORC1 and mTORC2 2475 5728 7942 6009 3064 PMC8424797__F1 LncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy 2308 10379 920 PMC8430856__F2 Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance 5164 4193 637 572 5728 51499 PMC8431530__F3 Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis 1719 4524 4397 4548 635 875 PMC8436174__F1 HER2-Directed Therapy in Advanced Gastric and Gastroesophageal Adenocarcinoma: Triumphs and Troubles 5728 2475 4193 1956 PMC8437644__F7 Studies on the Role of circRNAs in Osteoarthritis 1101 1832 100187761 948 961 PMC8437933__F7 Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway 4905 10468 7263 PMC8443620__F2 Metabolic capabilities in three new actinobacterial classes 7054 4118 1636 PMC8447736__F5 Bioinformatics analysis of SARS-CoV-2 infection-associated immune injury and therapeutic prediction for COVID-19 940 6945 10874 5020 5367 5429 5447 6476 1610 1392 7432 3953 PMC8449655__F1 De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3‐hydroxylase with 2‐hydroxylase side activity 2152 2271 2023 PMC8465517__F4 Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease 6667 468 83939 PMC8468657__F3 Iterative Upgrading of Small Molecular Tyrosine Kinase Inhibitors for EGFR Mutation in NSCLC: Necessity and Perspective 1956 2475 1950 5728 PMC8468723__F3 NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective 2932 5111 6774 PMC8468876__F2 Gamma-Aminobutyrate (GABA) Regulated Plant Defense: Mechanisms and Opportunities 4967 65220 7054 847 PMC8468939__F8 Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells 1956 3717 6774 1950 PMC8471358__F3a Ketogenic Diets in Pancreatic Cancer and Associated Cachexia: Cellular Mechanisms and Clinical Perspectives 3479 3480 3845 2475 PMC8471828__F6 Ferroptosis Meets Cell–Cell Contacts 999 26524 9113 2182 PMC8472725__F1 Alpha-Synuclein and the Endolysosomal System in Parkinson’s Disease: Guilty by Association 8411 3916 3920 PMC8474014__F8 Transcriptomic and Metabolomic Analyses Provide Insights Into an Aberrant Tissue of Tea Plant (Camellia sinensis) 2271 79866 3630 PMC8487426__F5 Alcohol use disorder (AUD)-associated miRNA–mRNA regulatory networks in the nucleus accumbens (NAc), the prefrontal cortex (PFC), the putamen (PUT), and the ventral tegmental area (VTA) of AUD subjects (the Set 1 sample) 7454 4099 64167 1356 391 PMC8491037__F7 Triacylglycerol remodeling in Physaria fendleri indicates oil accumulation is dynamic and not a metabolic endpoint 95 4018 5091 PMC8492275__F1 Therapeutic Effects of Polyphenols on the Treatment of Colorectal Cancer by Regulating Wnt Beta-Catenin Signaling Pathway 324 1499 4397 PMC8495593__F3 Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers 7508 5111 7507 PMC8501036__F7 Proposed mechanistic pathway for the Fe2O3@KO2/zeolite catalyzed hydrogenation of CO2, highlighting the efficacy of our multifunctional system 55364 1690 2241 PMC8502875__F5 Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1 2932 5266 6722 PMC8504269__F2 Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells 387 5163 860 PMC8507231__F1 Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases 132 100 367 PMC8507250__F8 Nanoselenium transformation and inhibition of cadmium accumulation by regulating the lignin biosynthetic pathway and plant hormone signal transduction in pepper plants 914 790 1312 PMC8507617__F1 Hedgehog Signaling in Myeloid Malignancies 51684 2736 6608 PMC8509056__F6 Molecular and Metabolic Insights into Anthocyanin Biosynthesis for Leaf Color Change in Chokecherry (Padus virginiana) 5617 4149 4602 PMC8511707__F1 Fatty Acids Derivatives From Eukaryotic Microalgae, Pathways and Potential Applications 355 95 1674 PMC8516553__F5 Insights into the Role of Oxidative Stress in Ovarian Cancer 4040 4041 324 1499 PMC8517477__F1 STING Signaling and Sterile Inflammation 115004 29110 3661 100187761 2522 PMC8518235__F8 Endometrial regenerative cells with galectin-9 high-expression attenuate experimental autoimmune hepatitis 920 940 3932 27040 51083 PMC8524770__F3 Sex hormones in lung cancer 8168 6387 7852 PMC8526190__F1 Neutrophil Extracellular Traps (NETs): Opportunities for Targeted Therapy 4353 4827 1431 PMC8528922__F3 Genes involved in the Taxol biosynthetic pathway 3652 7263 5066 7054 6651 PMC8533518__F1 Enhancement of Beta-Alanine Biosynthesis in Escherichia coli Based on Multivariate Modular Metabolic Engineering 4118 1636 11113 443 PMC8533981__F5 Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer 1499 595 581 2475 PMC8534102__F3 Mental Illness and Amyloid: A Scoping Review of Scientific Evidence over the Last 10 Years (2011 to 2021) 23621 351 100187761 PMC8537491__F2 Cellular Signalling and Photobiomodulation in Chronic Wound Repair 2475 1977 3397 64750 57154 2885 PMC8539415__F1 Metabolic Perturbation and Synthetic Biology Strategies for Plant Terpenoid Production—An Updated Overview 727 3652 5805 4026 PMC8542988__F3 Shedding Light on Microbial “Dark Matter”: Insights Into Novel Cloacimonadota and Omnitrophota From an Antarctic Lake 5901 7263 2689 PMC8558397__F1 Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges 8213 324 1499 1956 PMC8561419__F3 Prenatal inflammation as a link between placental expression signature of tryptophan metabolism and preterm birth 8942 5805 8567 PMC8573224__F4 In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment 3250 5805 3258 2597 4118 4397 1636 1431 11113 6120 1896 PMC8573224__F5 In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment 3250 5805 2597 100 4118 4397 1636 1431 11113 6120 1896 PMC8575484__F3 Identification of Candidate Genes Related to Synovial Macrophages in Rheumatoid Arthritis by Bioinformatics Analysis 572 5183 4118 PMC8576385__F3 Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout 4638 831 140821 572 4118 717 PMC8582349__F3 MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets 5901 29102 27161 PMC8584226__F3 Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases 5091 4018 2475 PMC8588006__F4 Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis 7096 7097 4615 PMC8592571__F8 Proposed cold-induced vasoconstriction signalling pathway in young and aged mice 8989 79054 4280 PMC8602792__F4 Novel Therapeutic Targets in Liver Fibrosis 6608 51684 2932 PMC8606765__F1 T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells 324 958 941 942 940 920 3458 50943 PMC8615798__F6 Association of Mutations Identified in Xanthinuria with the Function and Inhibition Mechanism of Xanthine Oxidoreductase 4337 4338 27304 10243 55034 PMC8617206__F4 JAK/STAT signaling pathway: from bench to clinic 6774 6778 4086 10379 6772 6773 10401 207 PMC8620617__F4 Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye 7276 64220 9227 5950 PMC8623046__F9 Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway 9817 10468 581 PMC8623138__F1 Microalgae Xanthophylls: From Biosynthesis Pathway and Production Techniques to Encapsulation Development 1431 3652 727 PMC8630009__F8 Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology 717 3240 1610 367 183 PMC8634864__F2 Evolution of memory system‐related genes 771 6714 4118 PMC8638432__F12 Exosomal microRNA-107 reverses chemotherapeutic drug resistance of gastric cancer cells through HMGA2/mTOR/P-gp pathway 2638 2475 8091 PMC8640120__F1 Pro- and Anti- Effects of Immunoglobulin A- Producing B Cell in Tumors and Its Triggers 920 7054 958 2638 PMC8640216__F1 Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin 22926 83939 468 PMC8645368__F2 Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation 6387 6347 3620 PMC8655846__F1 TypiCal but DeliCate Ca++re: Dissecting the Essence of Calcium Signaling Network as a Robust Response Coordinator of Versatile Abiotic and Biotic Stimuli in Plants 5091 4691 867 2241 759 7018 PMC8659262__F1 Co-Production of Isoprene and Lactate by Engineered Escherichia coli in Microaerobic Conditions 4598 4597 3652 PMC8660813__F9 Kinetin-induced death of Vicia faba ssp. minor root cortex cells 3258 22944 84890 PMC8670125__F7 Proteomic and biochemical responses to different concentrations of CO2 suggest the existence of multiple carbon metabolism strategies in Phaeodactylum tricornutum 3250 5132 4118 5009 PMC8671294__F1 Purinergic Signaling in the Regulation of Gout Flare and Resolution 4615 114548 8544 PMC8678573__F3 Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System 8773 2534 6850 5091 PMC8688651__F1 Network map of apelin-mediated signaling 847 8168 4118 7808 8405 4117 5970 23111 100187761 140805 31 367 5447 PMC8690056__F1 Nicotinamide and acute kidney injury 23475 93100 10135 952 23098 PMC8697445__F1 Enhanced production of Gamma-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation 4118 847 11113 PMC8699097__F1 Therapeutic Targets of KRAS in Colorectal Cancer 5900 5163 2885 11186 PMC8699888__F1 Cellular Senescence in Adrenocortical Biology and Its Disorders 1017 1021 1019 PMC8705212__F4 Camptothecin Encapsulated in Beta-Cyclodextrin-EDTA-Fe3O4 Nanoparticles Induce Metabolic Reprogramming Repair in HT29 Cancer Cells through Epigenetic Modulation: A Bioinformatics Approach 57103 2539 2271 47 27159 7086 10606 5471 2618 29920 PMC8707026__F1 Molecular Rationale of Insect-Microbes Symbiosis—From Insect Behaviour to Mechanism 7018 847 7187 PMC8708027__F1 Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review 1956 5728 7039 2885 PMC8709197__F7 Global Metabolic Map Defines the Effects of a Si-Based Biostimulant on Tomato Plants under Normal and Saline Conditions 1081 847 266710 6476 5813 PMC8712697__F3 Comparative Genomic Analysis of Labrenzia aggregata (Alphaproteobacteria) Strains Isolated From the Mariana Trench: Insights Into the Metabolic Potentials and Biogeochemical Functions 63908 6957 6955 PMC8716696__F4 Impact of Rubella Virus Infection on a Secondary Inflammatory Response in Polarized Human Macrophages 114609 4615 3661 7297 3716 6773 6772 PMC8719641__F3 New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris 5805 130589 2821 PMC8727737__F2 JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance 2475 56940 11122 5789 PMC8739177__F1 Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF 100034700 23111 5447 1390 PMC8745251__F2 Bile Acid Metabolism to Improve Plasma Lipid and Lipoprotein Profiles 2264 9965 64240 1581 PMC8745448__F1 Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion 948 57406 4099 4018 2548 2864 PMC8753987__F6 Top-Down Enrichment Strategy to Co-cultivate Lactic Acid and Lignocellulolytic Bacteria From the Megathyrsus maximus Phyllosphere 5132 6120 7504 PMC8759529__F1 Histiocytoses converge through common pathways 238 2475 867 5781 595 PMC8759533__F1 ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition 2475 867 595 5781 238 PMC8760362__F2 Zika virus infection of the placenta alters extracellular matrix proteome 100507436 197 4117 3240 25801 325 3815 PMC8777261__F4 Proteomic analysis of metabolic pathways supports chloroplast–mitochondria cross‐talk in a Cu‐limited diatom 2821 2597 5091 1896 PMC8786145__F2 Renal Sensing of Bacterial Metabolites in the Gut-kidney Axis 2475 920 4942 81285 PMC8787129__F11 Liver Fibrosis—From Mechanisms of Injury to Modulation of Disease 6010 1636 3717 PMC8790316__F3 Central Role of Extracellular Vesicles in the Mechanisms of Thrombosis in COVID-19 Patients With Cancer and Therapeutic Strategies 7018 7450 3552 324 5091 7054 PMC8790554__F2 Celiac disease: From genetics to epigenetics 55000 7374 283131 9863 7018 PMC8790935__F2 NLRP3 Inflammasome in Myocardial Ischemia-Reperfusion Injury and Ventricular Remodeling 140609 10628 114548 90550 100653365 PMC8799033__F6 Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer 1101 7450 960 948 961 PMC8802973__F1 Safety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL) 7124 3718 6774 6778 PMC8804744__F3 Mitochondria in Physiology of Chondrocytes and Diseases of Osteoarthritis and Rheumatoid Arthritis 1950 3553 581 PMC8818883__F4 Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis 7124 7186 8772 83737 4703 PMC8820687__F1 Brain as a source and a target of prolactin in mammals 5618 2885 5617 3717 6714 2592 PMC8824439__F1 CCM in Mtb 4163 4118 11113 PMC8840921__F2 Aplysia Neurons as a Model of Alzheimer’s Disease: Shared Genes and Differential Expression 5970 4615 330 PMC8858030__F3 Mass spectrometry imaging reveals substrate channeling by the purinosome, a liquid-like multi-enzyme assembly 5471 7808 5198 10606 158 8833 PMC8863366__F1 Blocking cholesterol storage to treat Alzheimer’s disease 348 19 38 4864 10577 22937 PMC8870839__F2 Iron in Porphyrias: Friend or Foe? 211 212 5498 210 1371 7390 7389 9049 PMC8875540__F3 Transcriptomic Analysis of Fish Hosts Responses to Nervous Necrosis Virus 2521 1522 925 55746 6955 26278 23347 79132 94240 2113 91543 10148 PMC8877168__F4 The NFKB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV 7054 4099 5972 3553 4791 6351 7124 8837 5743 7185 5328 PMC8877852__F1 Characterization and Interaction Analysis of the Secondary Cell Wall Synthesis-Related Transcription Factor PmMYB7 in Pinus massoniana Lamb. 1312 275 790 PMC8878749__SF2 Nanosized Codelivery System Based on Intracellular Stimuli-Triggered Dual-Drug Release for Multilevel Chemotherapy Amplification in Drug-Resistant Breast Cancer 5805 4860 960 PMC8879981__F1 Unravelling Formaldehyde Metabolism in Bacteria: Road towards Synthetic Methylotrophy 9242 4163 2548 PMC8892604__F3 Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives 948 2744 100187761 PMC8896082__F1 Effects of the probiotic cocktail on modulation of the NF-kB and JAK/STAT signaling pathways involved in the inflammatory response in bowel disease model 114609 4615 51135 64127 3717 3718 PMC8909928__F1 Fibroblast Growth Factor 23 and Osteoporosis: Evidence from Bench to Bedside 7421 8074 846 5741 PMC8911477__F3 Dysregulation of mTOR Signaling after Brain Ischemia 3479 627 7249 7248 6009 PMC8913403__F3 Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review 637 790 581 PMC8920690__F1 Nervous System Contributes to the Tumorigenesis and Progression of Human Digestive Tract Cancer 367 3480 6714 PMC8921549__F5 Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury 5925 9817 581 PMC8921673__F1 Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration 3667 28 2932 PMC8921673__F2 Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration 2932 9882 351 5140 126669 2885 PMC8939180__F4 Metabolome and transcriptome analyses identify the plant immunity systems that facilitate sesquiterpene and lignan biosynthesis in Syringa pinnatifolia Hemsl. 4598 4597 3652 790 1312 PMC8942302__F6 STAT3 pathway in cancers: Past, present, and future 6774 1956 1950 6714 PMC8944605__F3 MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Redox Control of Cell Senescence 2626 2146 648 440823 652995 100124700 3091 10135 2152 23410 23408 22933 23411 51548 23409 51547 283120 PMC8946552__F4 Ferric Nitrilotriacetate in Renal Carcinogenesis and Cell Death: From Animal Models to Clinical Implications 2879 10162 2182 1719 PMC8947257__F8 Proposed model of RTK bypass pathway activation in Tpl2 -/- keratinocytes 1956 6774 2885 3643 2475 PMC8953329__F1 An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications 2717 11113 4810 PMC8960495__F7 In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice 1356 85458 58480 27122 PMC8960495__F9 In utero exposure to electronic-cigarette aerosols decreases lung fibrillar collagen content, increases Newtonian resistance and induces sex-specific molecular signatures in neonatal mice 1356 7939 58480 6790 54093 3845 PMC8961234__F4 Unraveling the regulation of sugar beet pulp utilization in the industrially relevant fungus Aspergillus niger 137735 367 2582 PMC8961591__F1 Pathophysiology of H2S in Renal Glomerular Diseases 875 847 1610 PMC8970309__F2 Overcome Drug Resistance in Cholangiocarcinoma: New Insight Into Mechanisms and Refining the Preclinical Experiment Models 324 847 10257 9429 PMC8971568__F1 Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus 7038 338 335 3156 2194 PMC8972406__F1 Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System 5805 4810 7067 PMC8980436__F3 Cancer Metabolism: The Role of Immune Cells Epigenetic Alteration in Tumorigenesis, Progression, and Metastasis of Glioma 1956 6774 2475 6657 2932 PMC8988049__F7 Proteome-Level Investigation Into Plasmodiophora brassicae Resistance in Brassica napus Canola 7896 2077 4602 4609 PMC8990307__F2 Microglia and Neuroinflammation: Crucial Pathological Mechanisms in Traumatic Brain Injury-Induced Neurodegeneration 114548 79792 3661 7099 54209 942 PMC8994495__F6 Network diagram of “component-target-pathway” 581 5566 1956 140821 351 4099 2022 5241 43 PMC8997969__F2 Metabolic Reprogramming and Its Relationship to Survival in Hepatocellular Carcinoma 1356 133 226 47 31 4018 5091 PMC8998918__F4 Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer 5728 367 572 2078 7018 5327 5328 6935 PMC8998929__F1 Hippo Signaling in the Endometrium 122786 6789 2475 5728 PMC8999913__F6 Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum 29956 6723 91012 PMC9001662__F8 In DR, increased levels of LPS activates the inflammasome in typical and atypical forms 114548 3553 84890 79792 PMC9007636__F4 Expression Profiles of HOXC6 Predict the Survival of Glioblastoma Patients and Correlate with Cell Cycle 2645 1362 1311 3266 100187761 10763 3223 7851 PMC9010822__F3 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances 5290 7045 4118 PMC9013808__F3 cAMP-Dependent Synaptic Plasticity at the Hippocampal Mossy Fiber Terminal 9465 5864 91683 PMC9019758__F9 Bushen Culuan Decoction Ameliorates Premature Ovarian Insufficiency by Acting on the Nrf2/ARE Signaling Pathway to Alleviate Oxidative Stress 4094 4118 847 1191 571 PMC9020238__F2 Hepatitis C virus core protein: Not just a nucleocapsid building block, but an immunity and inflammation modulator 7096 7097 325 4615 7189 PMC9021453__F6 Regularity of Toll-Like Receptors in Bovine Mammary Epithelial Cells Induced by Mycoplasma bovis 4615 10333 3661 3665 PMC9027133__F5 Research Status of the Orphan G Protein Coupled Receptor 158 and Future Perspectives 57512 2239 858 627 6000 367 PMC9032823__F7 Metabolism of the Genus Guyparkeria Revealed by Pangenome Analysis 6120 7086 100379198 PMC9035535__F1 Gut Microbial Community and Host Thermoregulation in Small Mammals 6588 7350 7352 7099 PMC9035589__F9 Microbial Utilization of Next-Generation Feedstocks for the Biomanufacturing of Value-Added Chemicals and Food Ingredients 4397 5132 1431 847 65220 355 PMC9038119__F3 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species 125061 93100 8942 10135 3242 PMC9038119__F5 Targeting metabolic pathways for extension of lifespan and healthspan across multiple species 353 132 158 10606 7498 PMC9039247__F2 Cellular Metabolism in the Formation of Neutrophil Extracellular Traps in Airway Diseases 24145 4353 2744 PMC9040001__F6 Comparative transcriptomics discloses the regulatory impact of carbon/nitrogen fermentation on the biosynthesis of Monascus kaoliang pigments 7038 355 130589 2184 1431 PMC9047021__F1 Impacts of MicroRNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer 5901 54487 29102 PMC9052917__F7 Complement dysregulation is associated with severe COVID-19 illness 1401 3075 717 1431 PMC9069066__F5 Differential Physiological, Transcriptomic, and Metabolomic Responses of Paspalum wettsteinii Under High-Temperature Stress 130589 6390 5371 847 PMC9085840__F2 Pathways of mitophagy 10133 367 79735 PMC9086828__F3 Microglia in the Neuroinflammatory Pathogenesis of Alzheimer’s Disease and Related Therapeutic Targets 3566 948 6352 51094 23621 PMC9097084__F9 Transcriptional Profiling of Resistant and Susceptible Cultivars of Grapevine (Vitis L.) Reveals Hypersensitive Responses to Plasmopara viticola 2077 4602 412 PMC9100643__F3 Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes 5805 7086 3535 PMC9100681__F5 Unraveling the Role of Acetic Acid Bacteria Comparing Two Acetification Profiles From Natural Raw Materials: A Quantitative Approach in Komagataeibacter europaeus 2597 5183 2271 5132 1431 PMC9125579__F4 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues 4118 90550 759 7220 PMC9132726__F2 Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium 23432 6608 10142 PMC9133881__F5 miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network 1499 650 652 9355 26281 27121 1896 10913 128178 5091 8213 5315 11113 PMC9142813__F1 Cellular and molecular basis of thyroid autoimmunity 7038 7173 7054 7253 PMC9147752__F2 Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration 4666 2475 2353 3725 54795 PMC9151343__F1 Metabolic engineering of Vibrio natriegens for anaerobic succinate production 5805 4118 2271 4397 1431 11113 PMC9152215__F4 Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition 847 27343 7054 7913 176 PMC9153171__F2 Metabolomic, proteomic and lactylated proteomic analyses indicate lactate plays important roles in maintaining energy and C:N homeostasis in Phaeodactylum tricornutum 4118 1431 11113 PMC9163393__F3 Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression 7371 6774 4313 1950 1956 PMC9164031__F6 Inhibition of eNOS Partially Blunts the Beneficial Effects of Nebivolol on Angiotensin II-Induced Signaling in H9c2 Cardiomyoblasts 2475 6194 5879 PMC9168780__F11 Emerging roles of cystathionine Beta-synthase in various forms of cancer 596 2475 9817 875 7298 PMC9170600__F1 Effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential 10135 203447 93100 PMC9170767__F3 FunHoP: Enhanced Visualization and Analysis of Functionally Homologous Proteins in Complex Metabolic Networks 27159 23269 847 PMC9174413__F7 Comparative proteomic analysis on chloroplast proteins provides new insights into the effects of low temperature in sugar beet 57716 5091 847 PMC9178270__F1 Immune Regulator Retinoic Acid-Inducible Gene I (RIG-I) in the Pathogenesis of Cardiovascular Disease 57506 29110 3661 PMC9178347__F2 Critical metabolic pathways and SAD/FADs, WRI1s, and DGATs cooperate for high-oleic acid oil production in developing oil tea (Camellia oleifera) seeds 412 2597 7504 PMC9184225__F6 Improvement of Biosynthetic Ansamitocin P-3 Production Based on Oxygen-Vector Screening and Metabonomics Analysis 4118 11113 2695 PMC9191825__F2 Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19 2242 3728 4118 6497 PMC9200284__F2 Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy 203 84890 100 952 PMC9214054__F8 Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism 4280 152559 1643 PMC9220155__F3 Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation 9817 7099 7019 1051 23621 114548 115004 54106 65018 PMC9226217__F2 Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells 4615 4118 7096 929 PMC9229764__F2 Variation in the Humoral Immune Response Induced by the Administration of the BNT162b2 Pfizer/BioNTech Vaccine: A Systematic Review 940 941 355 324 59272 PMC9237610__F1 Genetic Manipulation of Biosynthetic Pathways in Mint 340451 3156 5241 PMC9238060__F2 Epigenetic modifications in drug resistance and treatment of breast cancer 6996 1788 1786 10873 PMC9239783__F6 Exploration of the Molecular Mechanism of Danzhi Xiaoyao Powder in Endometrial Cancer through Network Pharmacology 5328 1312 367 3265 PMC9243884__F3 IL-1 family of cytokines and receptors in pathogenesis of COVID-19 90865 100187761 1314 PMC9245023__F1 Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder 55183 7189 7099 4615 PMC9246955__F2 Riluzole regulates pancreatic cancer cell metabolism by suppressing the Wnt-Beta-catenin pathway 828 4117 351 572 4827 4397 PMC9249328__F8 Identification of VdASP F2‐interacting protein as a regulator of microsclerotial formation in Verticillium dahliae 51534 2147 5879 PMC9250200__F1 Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis 2475 2638 2492 PMC9254496__F1 Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways 4598 1756 3652 PMC9254539__F2 Lipid metabolism in tumor microenvironment: novel therapeutic targets 5728 3156 4598 4597 10654 6713 4047 PMC9255252__F1 Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication 3716 3717 324 51684 2736 PMC9256444__F5 Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting 2735 2736 6608 324 4040 4041 1499 2932 PMC9266688__F8 Tumor-Suppressor Role of the A1-Na/K-ATPase Signalosome in NASH Related Hepatocellular Carcinoma 2308 6714 1956 2475 PMC9276080__F1 MicroRNAs and their signaling pathway in mycosis fungoides 6774 50615 6775 3718 PMC9284871__F7 Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4 9242 4734 5728 6120 PMC9285505__F1 Hydrogen sulphide in liver glucose/lipid metabolism and non‐alcoholic fatty liver disease 4357 875 847 PMC9288068__F4 Exploring immunotherapy in colorectal cancer 6772 7054 3627 4283 6373 11201 920 PMC9288732__F2 Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes 10159 23400 2475 201163 65018 55737 120892 8398 54832 PMC9289111__F6 Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway 5728 2475 50943 PMC9289261__F2 Neuroimmune Interaction in Chronic Pain: A Review on Immune Cells in Peripheral and Central Sensitization 100379198 100187907 4615 PMC9290522__F3 Pathogenic Mechanism and Multi-omics Analysis of Oral Manifestations in COVID-19 4615 51135 7189 3663 7187 3665 57506 3661 7297 6773 7124 PMC9292941__F3 Genome of a nonphotosynthetic diatom provides insights into the metabolic shift to heterotrophy and constraints on the loss of photosynthesis 5183 1431 5091 1896 PMC9293517__F10 Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis 5091 4015 7124 PMC9298356__F1 CAM photosynthesis: the acid test 5183 718 1431 PMC9299865__F1 Key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions 10135 203447 93100 952 PMC9303011__F2 Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer 4149 6418 7018 PMC9304887__F1 Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery 27161 1956 4609 6774 PMC9305908__F1 17Beta-Estradiol Concentration and Direct B2-Adrenoceptor Inhibition Determine Estrogen-Mediated Reversal of Adrenergic Immunosuppression 367 581 666 847 PMC9309082__F2 Copper in the tumor microenvironment and tumor metastasis 475 3065 4205 4209 80312 6649 PMC9311231__F3 Metabolic assessment of tumors reveals alternative pathways for Trp catabolism 1545 55753 130013 PMC9311918__F3 mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases 2475 64798 3667 64223 PMC9313971__F1 Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated—A Systematic Review 7508 7507 5111 PMC9321204__F4 Glycine betaine uptake and metabolism in marine microbial communities 1757 635 29958 PMC9322890__F10 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) 3169 2475 1950 581 PMC9328443__F6 SNPeffect: identifying functional roles of SNPs using metabolic networks 100187761 1611 5995 PMC9328443__F3 SNPeffect: identifying functional roles of SNPs using metabolic networks 8139 7808 5995 PMC9330582__F1 Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer 201633 50943 6774 2475 920 100187761 55364 PMC9335447__F5 MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study 2235 1636 4199 1956 51199 4860 PMC9338328__F5 Radiotherapy combined with immunotherapy: the dawn of cancer treatment 6387 7852 6774 6347 729230 PMC9339672__F1 Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease 6651 2854 2841 PMC9354823__F1 Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy 8473 10724 2539 2597 5132 84532 55902 2271 47 2744 PMC9356167__F6 Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3B pathway 2932 7038 3553 PMC9356732__F3 Comparative Genomics of the Waterfowl Innate Immune System 10010 54472 100187907 1513 7018 351 1147 2353 PMC9360879__F5 IL-13 alleviates idiopathic pulmonary hypertension by inhibiting the proliferation of pulmonary artery smooth muscle cells and regulating macrophage infiltration 666 3621 847 83876 4118 PMC9364625__F2 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity 2475 948 1636 PMC9367281__F1 PTEN in Epithelial–Mesenchymal Transition 5728 7248 7249 6009 PMC9368823__F2 Cell Signaling Pathways and Non-Coding RNAs by Baicalein in Different Cancers 253260 54541 7249 7248 6009 PMC9369367__F1 Harnessing the Power of Purple Sweet Potato Color and Myo-Inositol to Treat Classic Galactosemia 2584 2592 468 83939 PMC9370349__F1 Alleviating Effects of Black Soybean Peptide on Oxidative Stress Injury Induced by Lead in PC12 Cells via Keap1/Nrf2/TXNIP Signaling Pathway 847 9817 10628 PMC9375293__F1 Targeting purine metabolism in ovarian cancer 5471 8833 100 4860 158 84890 PMC9379893__F1 An overview of mechanotransduction pathways in cells 57591 6714 6722 9780 59341 PMC9381850__F7 Comprehensive Analysis of Interferon Regulatory Factor Expression: Correlation with Immune Cell Infiltration and Patient Prognosis in Endometrial Carcinoma 8772 4284 10913 8205 1611 471 PMC9382032__F7 Genetic and transcriptome analyses reveal the candidate genes and pathways involved in the inactive shade-avoidance response enabling high-density planting of soybean 4118 126669 4099 PMC9385303__F10 Network Pharmacology Analysis, Molecular Docking, and In Vitro Verification Reveal the Action Mechanism of Prunella vulgaris L. in Treating Breast Cancer 351 355 7124 8717 4149 PMC9386474__F1 Oncogenic signaling pathway-related long non-coding RNAs for predicting prognosis and immunotherapy response in breast cancer 7039 4609 6418 PMC9393183__F2 Targeting thromboinflammation in COVID-19 – A narrative review of the potential of C1 inhibitor to prevent disease progression 5648 717 716 718 727 PMC9398856__F5 Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved 8471 3479 3667 8660 2475 6910 PMC9402773__F2 Wnt Signaling Pathways: A Role in Pain Processing 324 2932 1499 PMC9409683__F1 Regulatory Roles of Estrogens in Psoriasis 2078 7018 2852 PMC9424728__F9 Integrating physiology, genetics, and transcriptome to decipher a new thermo-sensitive and light-sensitive virescent leaf gene mutant in cucumber 7390 2973 7389 5447 210 1371 5498 PMC9424857__F1 Entner-Doudoroff pathway in Synechocystis PCC 6803: Proposed regulatory roles and enzyme multifunctionalities 1896 5624 5183 3250 183 2597 PMC9437628__F2 System level modeling and analysis of TNFA mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets 835 7124 8772 841 8717 7186 842 836 PMC9437888__F2 Developing a CRISPR‐assisted base‐editing system for genome engineering of Pseudomonas chlororaphis 3242 2641 7038 PMC9439701__F8 Specific microRNA Profile and Functional Networks for Children with Allergic Asthma 3630 100379198 6010 2638 PMC9441940__F1 Multiple myeloma metabolism – a treasure trove of therapeutic targets? 6509 26227 55902 PMC9454445__F2 Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer 23475 93100 65220 203447 952 10135 PMC9455597__F3 PARP inhibitor resistance in breast and gynecological cancer: Resistance mechanisms and combination therapy strategies 8505 91607 545 PMC9456096__F10 Metal Ion Periplasmic-Binding Protein YfeA of Glaesserella parasuis Induces the Secretion of Pro-Inflammatory Cytokines of Macrophages via MAPK and NFKB Signaling through TLR2 and TLR4 7097 4118 7189 4615 PMC9456549__F2 Targeting PI3K/AKT/mTOR Signaling Pathway in Pancreatic Cancer: From Molecular to Clinical Aspects 7249 2475 5728 PMC9459018__F4 Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots 4118 5447 435 PMC9459018__F6 Metabolome and RNA-seq Analysis of Responses to Nitrogen Deprivation and Resupply in Tea Plant (Camellia sinensis) Roots 3815 132 9615 4015 55821 5091 6955 6395 PMC9462519__F6 Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease 10392 7099 8767 3553 PMC9465410__F4 Exploring the mechanism of YangXue QingNao Wan based on network pharmacology in the treatment of Alzheimer’s disease 23621 351 5663 348 PMC9466598__F1 The hedgehog signaling pathway in rheumatic diseases: An overview 6608 51684 5167 54822 PMC9468207__F6 Meta-analysis highlights the key drought responsive genes in genes: PEPC and TaSAG7 are hubs response networks 100187761 2022 5972 6476 1674 PMC9469021__F10 Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Carassius auratus Linnaeus) gill disease caused by Myxobolus ampullicapsulatus 10803 3458 5476 3553 1508 PMC9476737__F4 Cytotoxicity of oleanane type triterpene from leaf extract of Pterospermum acerifolium (in vitro) and theoretical investigation of inhibitory signaling pathway 2475 5728 7248 7249 PMC9477818__F1 Antimicrobial potential of a ponericin-like peptide isolated from Bombyx mori L. hemolymph in response to Pseudomonas aeruginosa infection 1644 8772 23118 PMC9490047__F1 Current applications of adipose-derived mesenchymal stem cells in bone repair and regeneration: A review of cell experiments, animal models, and clinical trials 1499 4040 4041 860 7428 2915 PMC9490861__F3 Osteogenic differentiation of periodontal membrane stem cells in inflammatory environments 7099 7096 10333 4615 PMC9495330__F13 Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity 847 7097 7189 4615 7099 PMC9496435__F3 Targeted genes in the mitogen‐activated protein kinase pathway (MAPK) 7018 1616 65057 4117 2122 7157 90525 PMC9498834__F2 Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products 102 100188776 23493 PMC9507402__F2 Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage 79792 56169 1687 55876 PMC9508752__F3 Profiles of transcriptome and metabolic pathways after hypobaric hypoxia exposure 4397 7054 175 26136 PMC9510030__F1 Molecular inhibition of RAS signalling to target ageing and age-related health 2885 3667 4193 PMC9521228__F2 Successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARS-CoV2 infection and multisystem inflammatory syndrome in children 716 715 10747 717 PMC9523695__F6 Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway 2475 355 472 PMC9528770__F2 Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders 8717 8772 7186 2475 PMC9528914__F1 Polycystic Liver Disease: Pathophysiology, Diagnosis and Treatment 8315 673 6955 324 5091 PMC9530862__F2 Effect of fasting on cancer: A narrative review of scientific evidence 3479 2475 3920 23411 PMC9534868__F2 Activation of the canonical Wnt signaling pathway 324 4040 1499 54894 84133 PMC9535337__F1 Complement activation in Hidradenitis suppurativa: Covert low-grade inflammation or innocent bystander? 7124 2219 718 730 729 3458 966 2271 1378 717 735 7448 1380 PMC9537356__F5 On-Target Side Effects of Targeted Therapeutics of Cancer 1445 3084 2475 PMC9547606__F2 Platelets, Macrophages, and Thromboinflammation in Chagas Disease 5091 7018 2161 PMC9550351__F1 Emerging roles of microRNAs in the regulation of Toll-like receptor (TLR)-signaling 7096 7097 4615 51135 7189 23118 257397 3656 7187 3661 3665 PMC9553755__F6 Exploring Potential Biomarkers, Ferroptosis Mechanisms, and Therapeutic Targets Associated with Cutaneous Squamous Cell Carcinoma via Integrated Transcriptomic Analysis 7157 6790 7054 PMC9558278__F2 Identification of key gene networks controlling polysaccharide accumulation in different tissues of Polygonatum cyrtonema Hua by integrating metabolic phenotypes and gene expression profiles 2821 101448070 7360 2582 7358 4351 2762 PMC9561420__F2 Microbial dysbiosis and childhood asthma development: Integrated role of the airway and gut microbiome, environmental exposures, and host metabolic and immune response 7097 5132 3586 7099 7189 920 3661 29110 PMC9564314__F9 Emergence of MUC1 in Mammals for Adaptation of Barrier Epithelia 6714 5159 1956 2885 PMC9565660__F1 Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis 952 717 718 PMC9569764__F8 Developmental Transcriptome Analysis of Red-Spotted Apollo Butterfly, Parnassius bremeri 7851 355 7010 367 PMC9570183__F1 Polyphenols as Potent Epigenetics Agents for Cancer 168002 324 1789 PMC9576726__F7 Effects of MSC-Exos on glycolysis and renal fibrosis 9242 5213 7006 100124696 PMC9576796__F5 Proposed metabolic pathway for anaerobic propane oxidation coupled to nitrate reduction 8772 5096 4524 PMC9579336__F2 Synthesis, function, and regulation of sterol and nonsterol isoprenoids 7054 3156 3652 6009 3949 29914 22937 PMC9588473__F4 High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach 27122 7042 6932 920 27123 6422 PMC9589297__F4 Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects 54822 7046 4087 4088 PMC9598519__F10 Glutathione and Glutaredoxin in Redox Regulation and Cell Signaling of the Lens 1956 2885 6714 PMC9598866__F5 Metabolite Profiling of Paraquat Tolerant Arabidopsis thaliana Radical-induced Cell Death1 (rcd1)—A Mediator of Antioxidant Defence Mechanisms 2744 3652 51083 PMC9600404__F3 Newest Therapies for Cholangiocarcinoma: An Updated Overview of Approved Treatments with Transplant Oncology Vision 2263 2475 5728 PMC9600751__F3 Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions 5728 2475 5979 673 50507 7173 PMC9600751__F4 Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions 5728 2475 100144748 143 100216001 PMC9603526__F2 Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease 875 847 1610 PMC9611148__F2 STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway 115004 83939 3661 PMC9616781__F1 Molecular Effects of Environmental Enrichment on Alzheimer’s Disease 5340 23621 627 2002 PMC9617413__F4 Transcriptomic and metabolomic analyses for providing insights into the influence of polylysine synthetase on the metabolism of Streptomyces albulus 1611 5162 6390 PMC99537__F5 Basic metabolic pathways in C 2690 2242 5805 PMC99857__F9 The B(a)P-induced apoptotic signaling pathway, which is mediated by APIX 998 5879 5058 PMC10036181__F4 Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease 3934 22943 50964 8074 PMC10037512__F6 Mechanism of STX5 involvement in HCC metastasis 6811 2475 790 PMC10040812__F8 Signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet B cells in response to high glucose 6714 5879 387 PMC111167__F1 BR biosynthesis pathway 1362 2688 1431 PMC1195384__F2 Folate pathway in Plasmodium falciparum and the proposed mode of action of the diaminopteridines, analogs of folate precursors 1611 1725 2356 1719 PMC1383515__F6 Proposed tentative mechanism underlying MAFA-mediated selective inhibition of FcɛRI-induced cytokine gene transcription 2534 2002 2353 3725 PMC150988__F1 JAK-STAT signaling and the generation of Th1 and Th2 cells 6775 6778 3716 PMC1560097__F3 Light-cycle of rhodopsin 4827 4149 4397 PMC1774275__F1 Simplified diagram of the Wnt/APC pathway 1499 324 595 PMC1774677__F1 Diagrammatic indication of the cytokines, transcription factors, and signalling molecules which polarise virgin CD4 cells into T helper cell type I cells 6772 6774 6775 PMC1797319__F1 Shewanella oneidensis MR-1 anaerobic carbon metabolism pathway 11113 4118 100187761 PMC1817805__F2 AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer 355 7249 2475 PMC183833__F2 Canonical Wnt/Beta-catenin pathway 4041 10023 1499 324 595 6908 PMC1856802__F2 Canonical Wnt signalling pathway and its APC partner in colon cancer development 2932 1499 324 PMC1867370__F9 Root Phenotypes of Wild-Type, noxy2, and coi1-1 Plants Responding to Oxylipins.Ten-day-old seedlings grown on MS medium and in the presence of 9-HOT (25 μM), 9-oxo-C9 (15 μM), or JA (10 μM) 4397 4015 1674 PMC1885990__F1 Scheme depicting a molecular pathway by which cell-cycle-related molecules promote cell death in neurons in development and disease 6839 1874 1019 3065 PMC2000831__F3 Proliferation induced by androgen independent pathways 367 1950 7039 PMC2064427__F10 Schematic diagram illustrating the signaling mechanisms that control the bidirectional responses of the growth cone to BMP7 gradients 3984 6010 655 PMC2180420__F9 Co-coculture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells 2885 2534 1956 PMC2194080__F1 Proposed mechanism of CD4+ T cell priming after Leishmania major infection 4072 4615 920 PMC2212850__F2 Major signaling pathways for type I IFN gene transcription 54106 51284 7098 7099 4615 7189 29110 3663 3661 7124 PMC2217489__F4 F igure 4 5728 6009 2475 PMC2235216__F1 Arsenic-induced acquired androgen independence 367 2002 3725 2353 PMC2268740__F1 Neuroarchitecture of Aminergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster 7200 1644 7054 PMC2360544__F2 Novel therapeutic targets and proposed mechanisms of androgen resistance (text in red) in hormone refractory prostate cancer 367 103 100187761 2475 7113 PMC2386416__F1 Illustrations of the 5 Alpha-reductase action and the pathway of androgen action on target gene expression 367 1950 3479 7039 PMC2435380__F1 Methionine metabolic pathway 27232 635 4397 4524 875 PMC2536507__F2 Pathogen recognition systems 7187 7189 3661 PMC2546905__F4 Predicted targets of miR-100 and miR-101 in the 3′-UTR of members of the mTOR pathway 253260 2475 1977 PMC2574996__F12 We then examined the Pd-catalyzed oxidative kinetic resolution of hydroxyester (±)-15 1431 472 100271695 PMC2574996__F15 Our difficulty in suppressing epimerization at the bis-benzylic stereocenter bearing the ester in the azide displacement led us to pursue an alternate route to amurensinine via intermediates with attenuated acidity at the bis-benzylic carbon () 1431 472 100271695 PMC2585609__F1 A schematic representation of the functional domains of Stim and Orai proteins 57620 84876 80228 93129 PMC2593475__F1 PI3K/PTEN/Akt/mTOR Pathway 5728 2475 572 2522 PMC2635127__F4 PI3K/Akt non-Smad pathway 4088 4089 2475 PMC2639705__F9 Two Chromogranin A-Derived Peptides Induce Calcium Entry in Human Neutrophils by Calmodulin-Regulated Calcium Independent Phospholipase A2 340451 2638 1081 847 PMC2645343__F2a Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy 3082 1499 5340 PMC2675030__F3 Steps in the generation of Th17 cells 149233 6095 6774 50615 PMC2679749__F3 Control of autophagy 2309 83939 1874 2475 PMC2702690__F9 Molecular Mechanisms of HIF-1A Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells 650 2475 6774 10763 PMC2708980__F8 Proposed signaling pathway 10125 25780 581 596 PMC2715236__F6 Model for the role of FANCM in the DNA damage response 57697 2177 91442 PMC2725945__F1 Stabilization, degradation, and activation of the Ci/Gli proteins by the Hh signaling pathway 51684 6608 8405 PMC2727126__F1 Noteworthy, the inhibition of this pathway through COX-inhibitors leads to induction of apoptosis and tumor growth reduction (Figure ) 4015 26136 1950 PMC2730990__F2 TGFB can leave you breathless 324 7908 4155 PMC2744654__F5 ProMeTra visualization of relative metabolite pools and transcript abundances during fermentation of the l-lysine producer C 1738 3033 49 PMC2758233__F2 P75NTR-mediated signal transduction pathways 7189 3725 387 PMC2762943__F1 Epidermal growth factor receptor (EGFR) pathway 7039 1950 1956 2885 5728 PMC2766659__F4 Signaling molecules and pathways regulating the fate of spermatogonial stem cells 4089 652 2668 3975 6714 PMC2770326__F4 Pathway options for sialic acid glycoengineering 1690 10020 54187 PMC2785127__F5 Putative targets of common changes in gene expression with single and repeated IMO stress 7054 2353 8505 PMC2789270__F1 TGFB: A New Role for an Old AktTOR 4318 4313 2475 PMC2793058__F10 IFNG signaling pathway in retinal pigment epithelium 1080 3716 6772 PMC2835321__F6 Retrograde mechanisms in NMJ formation 474168 5979 2668 PMC2846691__F1 Pathways initiated by ACSL, FATP, and ACSBG isoforms 4018 5091 5183 PMC2858442__F3 Model of CD95-mediated signaling 1431 718 7939 729 PMC2867412__F2 Proposed role for AMPK in the kidney in coupling catabolic pathways requiring ATP hydrolysis (primarily sodium transport) with metabolic pathways leading to ATP synthesis (primarily fatty acid and glucose oxidation) 1080 1938 2475 PMC2871922__F4 Regulation of spermatogenesis processes by non-classical testosterone signalling 1956 2492 367 PMC2885761__F2 Schematical overview of the signaling pathway mediated by MC1R 4157 4286 5873 PMC2892252__F1 Host responses to Candida albicans: Th17 cells and mucosal candidiasis 920 3553 6774 3605 PMC2894370__F4 “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology 5728 6009 7249 2475 3091 7428 PMC2935335__F1 The highly simplified PI3K/Akt and MAP kinase pathways in thyroid cancer 5979 5728 673 2475 PMC2955448__F1 Pathogenesis of prostate cancer: from molecular to metabolic alterations 5728 5594 47 355 3156 PMC2958210__F12 Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice 3652 885 6651 761 5091 PMC2976847__F1 Cytokines, hormones or growth factors that activate Stat5 2056 7173 5008 1950 3717 6776 6777 572 PMC2978002__F7 Model demonstrating the specific apoptotic effect of SREBP-1 and FAS inhibition on GBM cells bearing EGFRvIII 1956 5728 355 2475 PMC3008633__F1 Examples of reaction–diffusion processes in muscle 4151 5091 1431 3371 PMC3010690__F2 Zinc metalloprotease activity in APP processing 351 2717 3416 PMC3033145__F2 Anticoagulant properties of endothelial cells 324 7018 7035 5091 PMC3045562__F1 Neural pathway for habituation in response to odors 100187761 4151 183 7038 PMC3047474__F1 Architecture of intestinal TD and TI IgA responses 85480 920 958 5284 PMC305600__F7 An EGF receptor/Ral-GTPase signaling cascade regulates c–Src activity and substrate specificity 1956 6714 126669 6774 PMC3062534__F1 Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort 718 2271 3426 3075 PMC3070284__F2 Endothelial growth factor receptor (EGFR) signaling pathway 1950 1956 2885 2475 PMC3087924__F1 Autophagy in macrophages 6774 6778 2475 PMC3110060__F1 MicroRegulators come of age in senescence 406920 648 2002 3654 8091 1019 1021 23411 595 9134 PMC3110730__F1 Wnt signaling and regulation of Beta-catenin in tumorigenesis 1499 324 1387 6925 595 PMC3126020__F2 Targeting the Hedgehog pathway in cancer 5727 6608 51684 596 PMC3131147__F2 Possible pathways to androgen independence and the involvement of ANG 2475 367 1977 PMC3134325__F1 Action of ErbB receptor 7039 1950 2885 PMC3134613__F6 Specificity in neuronal activity-regulated gene transcription 2048 2309 627 2353 1179 PMC3136091__F1 Canonical and non-canonical NFKB signalling pathways 5970 602 5971 PMC3137255__F2 A simplified model for Hh signaling in mammalian cells 6608 91653 2736 51684 374654 PMC3152494__F7 The crosstalk between the NOTCH and AKT pathways at the molecular and cellular levels 4352 7173 5728 PMC3160786__F2 Amino acids sensing of mTORC1 Rag-Ragulator-dependent mTORC1 activation in response to amino acid 7249 4351 6009 PMC3163839__F3 Progression of amyloidogenesis in parahippocampal region and hippocampal formation of mediotemporal lobe 761 759 23411 PMC3186052__F6 Inhibition of prostate cancer cell proliferation through statin use, and its impact on the HMG-CoA pathway 367 5879 6010 PMC3189826__F7 Signaling pathways leading to 3D invasion of ErbB2 transformed MCF10 cells over-expressing p130Cas 2064 2475 5879 PMC3193288__F1 Innate immunity against RNA viruses in mammals 7098 57506 29110 3661 PMC3193874__F2 Caloric Restriction and Chronic Inflammatory Diseases 3480 3667 5728 PMC3199279__F2 Metabolic interactions between folates and vitamins B12, B6, and B2 4524 1719 635 2618 PMC3203699__F8 TRAF3-mediated positive and negative regulation of IFN signaling 7187 57506 10010 3661 3665 PMC3221743__F5 Working model describing how in HIV+ macrophages constitutively activated PI3K elicits blunting of lipid A-induced increases in TNFA release through sustained mTOR activation 7099 4615 2475 PMC3242418__F1 HER 2: Biology, Detection, and Clinical Implications 367 1950 3273 7039 7018 PMC3269020__F3 Role of miRNAs in aging of mice 23411 6667 3479 3480 596 PMC3277712__F1 Importance of cytokine signalling for CD4+ T-cell differentiation 920 50943 3569 2625 100196919 PMC3295626__F1 JAK-STAT intracellular signaling pathway in myelofibrosis 2056 3717 8651 2475 PMC3296959__F2 Innate immunity and the ubiquitin–proteasome system in PD 472 120892 9636 PMC3310155__F1 Model of CaS receptor sorting traffic 846 10267 10268 PMC3312480__F1 Schematic view of potential targets and site of action of some biologics in IBD 7054 324 4092 4089 PMC3317163__F2 One-carbon metabolism 4548 635 57412 PMC3322992__F8 Pathways required for the role of CDCP1 in EGF/EGFR-induced cell morphological changes and increased cell migration 1950 64866 1956 PMC3346990__F3 The potential molecular mechanisms of crosstalk between nuclear receptors LXR and FXR–SHP–LRH-1 regulatory cascade in the liver and intestine 8213 1581 9965 2264 PMC3358449__F1 Key components in the regulation of methionine metabolism 4482 635 4397 27232 875 PMC3376380__F1 mTOR signaling and its regulation by DGKs 7249 6009 7248 253260 2475 PMC3401974__F2 Mammalian target of rapamycin (mTOR) pathway regulates T-cell activation, differentiation and migration 324 940 2475 920 1236 PMC3418056__F5 Postulated interactions between 20-HETE and RAS in the vascular endothelium 1956 1636 183 367 PMC3445776__F1 The Hedgehog signaling pathway 5727 6608 51684 PMC3465263__F10 Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice 5728 100187761 5110 PMC3474187__F9 Methionine sulfoxide and methionine sulfoxide reductase (MSR) redox cycle 875 4482 1491 PMC3489757__F1 New insights on the role of CD8+CD57+ T-cells in cancer 3558 7040 10219 PMC3489928__F4 Proposed Reaction Pathway 367 1431 6476 PMC3492204__F5 A simplified scheme to illustrate the dual roles played by KIF7 in Indian Hedgehog (IHh) signaling and chondrocytes development 3549 6608 374654 PMC3494627__F3 Cancer-suppressive inflammation 3553 4615 7189 PMC3510123__F7 Eliminating the SLAC1 anion channel affects K+ channel activity, K+ uptake, and the rate of stomatal opening through its impact on and as predicted by the OnGuard model (; ) 4118 4827 1392 PMC3525024__F7 Schematic representation of canonical and noncanonical Hh signaling activation in MM 5727 6608 6469 595 PMC3531712__F1 p62-interacting partners and functions 7189 9817 2475 PMC3532456__F2 Transforming growth factor (TGF)B signaling pathway 5340 7939 387 7048 PMC3534848__F8 A proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and NO• generation in PAH 80312 6420 1585 PMC3545532__F2 Model depicting the canonical Nrf2 stress response pathway in each of the different phases: basal, preinduction, induction, postinduction 5728 2932 2534 2729 571 PMC3556263__F1 Molecular pathways affected by CR and irradiation 3479 3480 2475 PMC3557799__F3 Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting 51608 439 7485 PMC3565315__F1 Overview of the Hedgehog signaling pathway: a simplified model for Hh signaling in mammalian cells 6608 51684 374654 PMC3573271__F1 Role of aryl hydrocarbnon receptor (AHR) signalling on CD4+ T cells 50943 6772 196 PMC3591094__F8 LPA-LPAR1/3 GAi2–mediated activation of p130Cas in cell migration 4018 6714 6010 PMC3594782__F1 Serotonergic transcriptional networks and potential importance to mental health 121278 6697 5860 2643 PMC3599859__F1 CySBGN overview 170 1311 619410 PMC3620319__F3 An Integrated Approach to Uncover Driver Genes in Breast Cancer Methylation Genomes 3065 1870 7186 PMC3636549__F2 HEDGEHOG SIGNALING IN CHOLANGIOCYTES 6608 2735 2736 64399 PMC3639415__F8 The regulation and function of MYC in the androgen signaling pathway in molecular apocrine breast cancers 4609 367 3169 6934 4149 PMC3644335__F2 Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes 3949 29881 64241 64240 PMC3650130__F216 Recently, Anderson and co-workers described cycloisomerization of O-allyl oximes into pyrroles catalyzed by the Ir(I)/Ag(I)-combined system 238 367 5979 PMC3650130__F85 Recently, Zhang et al 472 238 367 PMC3672665__F1 Epithelial cancer cell inflammatory response 6774 1540 5728 PMC3675076__F5 Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy 6608 2736 3065 2735 PMC3677135__F6 The canonical Shh signaling pathway 6469 6608 51684 PMC3677135__F8 Intracellular mechanisms underlying Wnt-induced axon guidance 7474 1951 6259 PMC3686815__F9 Regulated Extracellular Choline Acetyltransferase Activity— The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway 1103 43 348 PMC3689254__F2 General scheme of EGFR activation 1956 5728 2475 PMC3697124__F3 Antibiotics doxycycline and minocycline inhibit inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi 1950 4049 114609 5971 PMC3712618__F4 Putative PGC-1-mediated mechanism of cancer-induced skeletal muscle wasting 3479 3667 2475 PMC3726373__F5 Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer 6240 5728 1000 PMC3734089__F1 Macrophages in pancreatic cancer initiation and progression 6774 6662 133 3845 PMC3742868__F11 Proposed scheme for the role of mTOR in p53-induced kidney cell injury 847 7157 355 PMC3743096__F4 Signal integration by mTORC1 coordinates nutrient input with biosynthetic output 83939 6009 7428 468 8607 10856 PMC3759646__F1 Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia 3479 3480 3667 238 2475 PMC3760546__F6 Natural inhibitors of coagulation and anticoagulant drugs.TF, tissue factor; VKA, vitamin K antagonists; AT, antithrombin; APC, activated protein C; TFPI, tissue factor pathway inhibitor type-1 7018 324 2147 PMC3761286__F1 Diagram showing Na-K-ATPase control of cell function by ouabain via its ion transport and signaling functions 1956 6714 759 2885 PMC3782237__F4 Mammalian target of rapamycin pathway is deregulated by mutations in cancer 1950 2475 5728 7248 7249 PMC3784161__F2 AKT controls T-cell differentiation 324 2475 253260 6009 4088 PMC3790664__F1 Comparing feedback mechanisms in morphogen signaling 1950 64220 9249 PMC3791171__F4 Molecular pathogenesis and mechanisms of thyroid cancer 7038 7253 7173 673 PMC3798724__F3 Hedgehog signaling pathway in the primary cilia 6608 51684 8405 PMC3825115__F1 Notch pathway effects on cytoskeletal plasticity 7275 8650 7054 PMC3826451__F4 Intracellular PRR signaling pathways involved in RSV and hMPV-induced gene expression 114548 64127 57506 3603 3661 PMC3827358__F8 Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway 7099 859 4734 PMC3830611__F1 Circuitry and biochemical basis for Tuberous Sclerosis symptoms: From Epilepsy to Neurocognitive deficits 7248 7249 6009 PMC3834200__F7 MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells 2668 2674 5979 346673 PMC3834580__F2 Future of targeted agents in metastatic colorectal cancer 1956 2885 2475 PMC3836174__F5 Hallmarks of Aging 3479 5728 23411 2475 PMC3857553__F2 Summary of Tim-3 expression on different innate immune cell populations and its functions 717 7098 51284 54106 PMC3868890__F2 Main synaptic signaling mechanisms of endocannabinoid and hypocretinergic systems 3061 3062 759 9118 PMC3886588__F1 Targeting the Th17 pathway 3553 84818 50615 149233 3603 PMC3903252__F7 Schematic illustration of the TGFB/ENaC pathway in a generalized alveolar epithelial cell monolayer, described in this study 4087 4088 5091 8394 50507 PMC3915289__F1 The kynurenine metabolic pathway 3553 8942 8564 23498 PMC3918413__F4 Transforming growth factorB (TGFB) signalling pathway 4090 4086 57154 64750 7018 PMC3921497__F4 Chitinase 3-like 1-associated Beta-catenin activation signaling pathway, which is inhibited by methylxanthine derivatives 1499 595 6908 PMC3923157__F2 Tumor necrosis factorA and its osteoblastogenesis paradoxical effects 64781 860 50964 4040 4041 PMC3928130__F4 AMP-activated protein kinase (AMPK) beyond metabolism 472 83667 6009 PMC3928706__F1 Mechanism underlying GD T cell killing of tumours: GD T cell receptor (TCR) interacts with isopentenyl pyrophosphate (IPP) generated through the mevalonate pathway in tumours 3652 4277 100507436 PMC3932922__F1 Cartoon presentation of LRRK2 showing multidomain structure 120892 2580 9529 PMC3936199__F3 Iron homeostasis in the liver 2056 148738 7036 3077 6774 1050 2057 164656 PMC3954954__F6 Tissue Factor Inflammatory Response Regulated by Promoter Genotype and p38 MAPK in Neonatal vs. Adult Microvascular Endothelial Cells 8717 1958 6667 7018 6774 PMC3982103__F1 Astrocytic–Neuronal–Astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA 5091 11113 4118 4969 PMC3983064__F9 Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation 7124 3553 7097 4615 6850 64170 54106 64127 PMC3991965__F2 Prostaglandin Analogues on Aqueous Humor Outflow Pathways 5228 1956 6010 1499 7018 PMC3993104__F2 Interplay between host and bacterial factors leads to tissue destruction, vascular leakage, and hyperinflammation in invasive GAS disease 920 324 6295 5340 5066 2597 PMC4007596__F2 Cytoscape plugin was used to analyze within Balb/c up-regulated genes, genes interaction within the same pathway and across different pathways 3725 230 3064 5594 PMC4009396__F2 microRNAs in cancer 29102 54487 57510 27161 PMC4013405__F3 nAChR-mediated signaling in lung squamous cell carcinomas and adenocarcinomas 1950 6714 1956 PMC4030154__F2 Metals and cholesterol implicated in AB processing and neurotoxicity 19 348 3416 100187761 3949 PMC4032892__F1 Schema of PI3K/mTOR and other oncogenic signaling pathways in hematologic malignancies 2475 5728 1977 PMC4063399__F2 Resistance to vemurafenib 5159 673 3082 PMC4086483__F1 NFKB signaling pathway 958 613 325 PMC4111999__F1 Schematic showing the possible integration of emerging, mass spectrometry-based technologies into the untargeted metabolomic pipeline 367 3423 4397 PMC4118485__F7 Simplified schematic showing the proposed mechanism of how SEs may suppress cellular immunity and antitumor responses 920 3718 6774 PMC4131037__F5 ChiBE overview 3458 7341 6772 8554 5771 PMC4132962__F1 Protective mucosal immunity mediated by epithelial CD1d and IL-10 324 6774 10808 4280 PMC4177985__F1 LD-Aminopterin in the Canine Homologue of Human Atopic Dermatitis: A Randomized, Controlled Trial Reveals Dosing Factors Affecting Optimal Therapy 5471 2618 7298 1719 PMC4178426__F6 Cell cycle pathway 8178 759 4118 PMC4189230__F1 Process and mechanisms of blood vessel formation 5156 6714 4087 4088 PMC4211077__F2 Advances in understanding of bile acid diarrhea 2264 9965 152831 PMC4232283__F8 Proposed working model 953 4907 84890 PMC4245781__F1 Signaling pathways of TRKA activation by NGF 4803 2885 3667 668 PMC4251064__F2 Dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) 7161 8626 3065 25942 PMC4256331__F11 The signaling pathways affected by Syk that drive AB production, neuroinflammation, and Tau hyperphosphorylation 6850 2932 23621 PMC4258820__F1 Representative ARG biosynthesis routes in prokaryotes 175 100653366 11113 PMC4279155__F1 The heme biosynthetic pathway and aspects of its regulation in hepatocytes 4599 3162 211 2235 7389 3145 PMC4287801__F1 Molecular pathogenesis and therapeutics of Marfan syndrome (MFS) 7038 2200 6885 4089 7018 PMC4320493__F7 Proposed model of the distinct features of Hh signal transduction in insect, fish and mammal 6608 5727 51684 PMC4334309__F2 Directed evolution of the nonribosomal peptide synthetase AdmK.Notes: Andrimid is biosynthesized by a hybrid nonribosomal peptide synthetase/polyketide synthase pathway 133 7038 4397 PMC4339542__F4a Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells 3716 6774 7018 PMC4342569__F8 The multi-targeted tyrosine kinase inhibitor vandetanib plays a bifunctional role in non-small cell lung cancer cells 5979 6010 85451 PMC4351152__F1 MTOR pathway is regulated by numerous upstream pathways, typically in response to growth factors (anabolic) or energy/nutrient deficiency (cell static or catabolic) 5728 6009 2475 253260 PMC4366432__F1 Epidermal growth factor receptor pathway 1956 673 2475 PMC4397421__F1 Translocations affecting the NFKB activation pathway 4615 84433 8915 7189 3550 329 5805 PMC4403007__F3 Intricacies of cardiac damage in coxsackievirus B3 infection: Implications for therapy 920 3661 7098 51284 PMC4434617__F1 Role of transmethylation reactions in alcoholic liver disease 4397 635 4524 5212 875 PMC4450349__F1 Of flies, mice and men: Evolutionarily conserved tissue damage responses and aging 474168 85451 4609 PMC4462367__F1 Schematic diagram of estrogen receptor (ER) signaling 5728 2475 6667 PMC4470747__F1 Innate Immune Evasion In Re-Emerging RNA Viruses 7706 7098 57506 7189 29110 3661 3665 27161 PMC4474341__F1 Biochemical pathways 3712 4163 26275 PMC4478296__F2 Mitogen-activated protein kinase (MAPK) signalling pathway 1956 3815 2885 2475 PMC4489880__F2 When pathways collide: collaboration and connivance among signaling proteins in development 6259 6714 387 PMC4497429__F1 The PI3K/Akt/mTOR signaling pathway and CSC biology 9429 253260 4072 PMC4503878__F6 Schematic representation of the dual role of 25-HC in the sterol biosynthesis pathway and the IFN--regulated innate immune response using SBGN system (inset shows key) 3156 467 9023 PMC4504805__F1 Schematic of BH4 de novo synthesis, salvage, and regeneration pathways and its role in 5-HT synthesis 121278 1719 231 PMC4515126__F1 Sirt1 controls the immune responses in macrophages 51548 23411 10135 PMC4520528__F2 B cell-derived cytokines direct the ensuing immune response 4397 4049 7124 PMC4521627__F3 Integrating physiological regulation with stem cell and tissue homeostasis 5728 7428 648 63976 PMC4524753__F2 Diagrammatic sketch shows the hypothetical mechanism of HOTAIR in digestive tract cancers 100124700 1499 10873 PMC4564397__F2 The NO/peroxynitrite signaling pathway A 27035 4025 5447 PMC4570748__F7 Redox control of the cellular energy metabolism 3091 2475 472 PMC4586784__F2 Modes of signaling in Hh pathway-dependent cancer 6608 5727 2735 64399 PMC4597337__F5 Molecular Mechanisms for High Hydrostatic Pressure-Induced Wing Mutagenesis in Drosophila melanogaster 3611 8650 3240 4734 100187761 PMC4611759__F1 Type I IFN gene expression 7098 51284 4615 29110 51135 3654 3661 PMC4613338__F1 Glutamine metabolism and potent targets for cancer therapy 8140 4609 2475 23657 PMC4614397__F1 Feedback regulation of PI3K/Akt/mTORC1 signaling by Grb10 5728 2887 2475 PMC4623426__F5 Reciprocal regulation of TGFB and Jak-Stat signaling 3458 6772 7018 PMC4624093__F1 Biomarkers of Angiogenesis in Colorectal Cancer 7424 5281 7423 7422 6714 PMC4628383__F1 Schematic representation of the brain microvasculature features and corresponding Impact of TS 1003 7412 5175 PMC4629494__F1 Pyruvate and octanoate metabolism in the liver 5091 1431 11113 PMC4631974__F2 Activation of PPARG by bioactive lipids can modulate signaling in progressive colorectal cancer 9314 4582 4854 PMC4671844__F2 MAPK signaling pathway in CRC 1956 2885 2475 PMC4673013__F1 MicroRNA interactome in metabolic homeostasis 7157 94241 100170220 PMC4673623__F1 Simplified diagram of one-carbon metabolism (1-CM) including the methionine cycle, the roles of one-carbon nutrients, and links to lipid metabolism 5091 4524 4397 635 10400 PMC4698395__F5 Mechanisms of stretch-induced reactive oxygen species (ROS) production and Ca2+ influx in dystrophic muscle 859 6714 5879 6261 PMC4712335__F8 Age-related neuroinflammation and changes in AKT-GSK-3B and WNT/ Beta-CATENIN signaling in rat hippocampus 1856 2932 1499 8313 PMC471568__F2 Schematic illustrating the current working hypothesis on the hormonal servomechanism regulating uterine gland morphogenesis and function in the ovine endometrium during pregnancy 5618 2690 7297 3716 PMC4729089__F1 Metabolic pathway of monoamine neurotransmitter synthesis and degradation 2643 367 5053 7054 PMC4748291__F5 Paediatric obstructive sleep apnoea syndrome (OSAS) is associated with tonsil colonisation by Streptococcus pyogenes 7099 4615 920 PMC4766407__F7 Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation 3553 3554 3556 3716 7189 3276 4615 PMC4773729__F2 Signaling mechanisms through the Janus kinase (JAK)/STAT pathway and action point of a JAK inhibitor tofacitinib 7173 2056 3716 3718 3717 7297 PMC4782155__F3 miR-146a-5p and miR-155-5p mechanism of action under normal conditions and early stages of inflammation (, , ) 7099 3654 7189 PMC4783290__F7 Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development 2118 4163 1431 5132 PMC4791944__F1 Longevity: Mapping the path to a longer life 3480 3643 2120 PMC4795462__F2 New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease 355 47 2744 PMC479700__F1 IFN-Gamma-inducible CIITA transcription from the type IV promoter is mediated by the Janus Kinase-1/Signal Transducers and Activators of Transcription-1 (JAK-1/STAT-1) signaling pathway 6772 7391 4261 PMC4813474__F10 Proposed model of the p8-regulated autophagy signaling pathway in response to palmitic acid stress 468 22926 83939 PMC4818393__F4 Integrative analysis of pathway features and the associated metabolites 226 7054 1491 PMC4822554__F1 Glucose promotes tumor growth by activating lipid synthesis and uptake upon N-glycosylation of SCAP 1956 22937 3949 PMC4825184__F1 TLR and NLR pathways driving pro-inflammatory state after exposure to extracellular and Intracellular microbial products 7100 4615 10392 29949 PMC4826392__F3 The dynamics of TET-mediated cytosine oxidation and its impact on DNA methylation patterns on regulatory elements in vivo 80312 200424 54790 6996 PMC4830836__F1 Notch canonical and non-canonical signaling 1499 7528 3091 PMC4835624__F1 Signaling through EGFR 2885 5728 2475 PMC4863577__F1 Hh pathway critical components which could be targeted by potential antibasal cell carcinoma drugs.Notes: The mechanism of action of each single drug is explained in the text 1956 51684 6608 PMC4867367__F5 Cross talk of GR with the STAT signaling pathway 6714 6774 7097 PMC4870071__F1 Hepatocyte growth factor/mesenchymal epithelial transition factor and phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway, and their inhibitors evaluated in gastric cancer patients 3082 2885 5728 2475 PMC4889588__F1 Schematic depiction of oncogenic MYC signal transduction 5728 2475 4609 1977 4149 2353 3725 PMC4896925__F2 Localization of AKAPs in T cells 920 367 847 PMC4899530__F14 Mechanism of Nrf2 activation by DMF and MMF and its role in neuroprotection 9817 571 4094 PMC4899583__F3 Schematic shows the potential role of epigenetic mechanism that may be involved in manganese induced chronic neurotoxic effects and in pathology of Parkinson's disease 6622 26281 572 PMC4906396__F5 Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes 5008 3717 6770 PMC4926799__F3 Summary of the mechanisms by which stress-related immune alterations may precipitate depression 6097 3553 85451 PMC4947825__F1 Cascades of the coagulation system 7018 7450 7035 5340 5091 PMC4950965__F2 Targeting the RB-E2F pathway in breast cancer 1019 1021 4609 PMC4959089__F1 General schematic model of a NR signaling pathway 5091 3240 2638 1283 PMC4969098__F3 Actions of IL-21 on T cells are context-dependent and shaped by cellular and environmental parameters 6772 6774 2475 6775 3662 PMC4972110__F1 Oncogenic addiction versus synthetic lethality to explain GSK621-induced cytotoxicity in AML 2475 83939 6009 PMC4973254__F5 Predictive Immunohistochemical Markers Related to Drug Selection for Patients Treated with Sunitinib or Sorafenib for Metastatic Renal Cell Cancer 7428 5728 5979 PMC4988688__F2 Hedgehog (HH) signaling pathways 5727 6608 51684 PMC4990059__F2 Canonical Wnt signalling pathway 1499 324 2932 PMC4995293__F5 Extracellular pH‐sensitive ion channels in the PNS 3786 3785 7442 PMC5026573__F6 JNK pathway activation modulates acquired resistance to EGFR/HER2 targeted therapies 1956 3480 85451 PMC5026797__F1 mTORC1 re-wires GI cell metabolism upon glycolysis inhibition to promote growth and proliferation 2539 2821 790 PMC5035020__F4 Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection 4838 729020 6497 2885 145258 11011 PMC5037500__F2 A glutamatergic synapse and the molecular circadian clockwork 2670 9575 4666 PMC5038225__F1 IGF-1R downstream signaling cascades 3479 3480 3667 2475 6774 PMC5059177__F1 Pterin and monoamine metabolism 1719 5053 7054 PMC5061788__F1 mTOR signalling pathway 2475 253260 1975 1977 27250 PMC5072688__F5 Power-Law Modeling of Cancer Cell Fates Driven by Signaling Data to Reveal Drug Effects 1956 6774 836 PMC5075576__F2 Complement-dependent cytotoxicity and inflammation 718 966 721 PMC5080925__F6 Model showing association of PAX5, CD19, CD3, p53, Ras, Raf, MAPK and Zap70 in B-cell and T-cell type non-Hodgkin's lymphoma 930 5079 7535 PMC5133786__F1 Proteolytic processing of the amyloid precursor protein (APP) and its modulation by vitamins A, D, E, and K 351 3416 8754 5212 PMC5133970__F7 Schematic representation of the proposed TCS pathogenesis model 6420 7555 7157 PMC5139081__F8 CF airway epithelium and pathogen adaptation 1080 4615 7097 PMC5146274__F8 Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis 10631 3690 3685 PMC5165017__F1 Working Hypothesis of mechanotransduction in EC cells 4397 857 63895 84890 PMC5216465__F8 Four possible pathways (circles) by which CNP could activate CFTR 2638 1267 1080 PMC5216829__F1 Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer 5728 2475 5281 5979 3815 PMC5219787__F3 Wnt signaling pathway 4040 4041 2932 324 847 PMC5240041__F3 Intracellular signaling pathways in lymphangiogenesis 7424 5879 2475 PMC5244394__F9 Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation 1950 1956 1103 PMC5248531__F2 Mechanisms by which alteration of normal miRNA profiles can occur, leading to aberrant miRNA profiles in childhood solid tumours 574449 4609 29102 54487 5901 57510 6895 23405 PMC5283711__F1 Redifferentiating Thyroid Cancer: Selumetinib-enhanced Radioiodine Uptake in Thyroid Cancer 5979 4893 2885 5728 2475 PMC5300302__F7 The trans-sulphuration pathway coupled with glutathione synthesis 4143 4144 875 1491 PMC5306062__F2 Cell death induced by benzopyran compounds by minor chemical modifications of the benzopyran scaffold 637 2021 2475 331 PMC5329138__F2 Cross-Talk between the Cytoplasmic RIG-I and STING Sensing Pathways 3454 3455 57506 7189 7187 PMC5333385__F2 Proposed biosynthetic pathway of sex pheromone production in female DBM moths (adapted from [, , ]) 355 1674 7808 367 PMC5343023__F3 Fatty acid (FA) and cholesterol sensing in T cell immune responses 50943 940 22937 PMC5343808__F1 Sonic Hedgehog Pathway: Shh acts on Ptch to inhibit the repression of Smo by Ptch 6608 51684 4609 PMC5348443__F2 Kinase inhibitors as potential agents in the treatment of multiple myeloma 958 5971 5970 PMC5349656__F1 Hh signaling pathway and RUSKI Hhat inhibitors 57758 6608 55733 PMC5354237__F2 Systemic damage responses of the fat body methionine metabolism (A) Methionine metabolism in Drosophila 27232 875 191 PMC5361678__F6 Resveratrol fuels HER2 and ERAlpha-positive breast cancer behaving as proteasome inhibitor 5728 6714 2475 253260 64798 PMC5366313__F5 Representative view of the iNKT/innate CD8(+) T-cell axis hypothesis in chronic myeloid leukemia (CML) 3606 8320 6010 912 PMC5367635__F1 Metabolic reprogramming in T cell fate and function 3575 355 7038 940 2475 PMC5380946__F2 Sumoylation promotes the stability of cGas and Sting and regulates the kinetics of the response to a DNA virus 59343 10475 3661 PMC5384354__F9 Proliferation by crosstalk of miR-204 and miR-17/92 in smooth muscle cells 5053 6714 6774 PMC5386521__F1 Scheme depicting a molecular pathway by which Cdc25A is induced/activated and promotes neuron death in disease and development 406991 993 1019 4602 PMC5410960__F16 Top illustration shows disruptions in normal cell survival and normal apoptosis in glioblastoma 2475 1956 355 1950 PMC5413074__F6 Canonical (NFKB1) pathway requires the NEMO (NFKB essential modulator) complex (IKB kinase A, IKB kinase B, IKB kinase G) to phosphorylate IKB, leading to its degradation 958 3569 6366 PMC5439240__F2 Paracellular intestinal barrier in health and inflammation 9075 7122 9073 PMC5440111__F2 Enhanced anabolic PI3K/Akt pathway in a cancer cell 2475 572 4609 47 PMC5460107__F2 FLT3 signaling pathway 2322 2885 2475 PMC5482702__F2 Hypoxia signalling pathway in haematological malignancies 7428 4609 5728 7173 1950 PMC5492089__F7 Schematic of canonical Hh pathway 6608 2735 7054 2737 PMC5502164__F1 Methylation cycle pathway: (A) Methionine and homocysteine (Hcys) are generated by the following enzymes: CBS = cystathionine Beta-synthase, MAT = methionine adenosyltransferase, MS = methionine synthase, SAHH = S-adenosylhomocysteine hydrolasa 4397 5212 875 2593 PMC5507649__F2 Targeting the ALK signaling pathway 238 5764 6801 6774 PMC5520901__F8 UCNPs-Ce6-mediated PDT and the mechanism of autophagy.Notes: UCNPs-Ce6-mediated PDT exhibits an autophagic response through the PI3K/Akt/mTOR signaling pathway that is regulated by ROS, which causes the ABCA1-dependent cholesterol efflux 4827 2475 19 PMC5528350__F1 miRNA deregulation in cancer 4609 54487 29102 5901 57510 27161 PMC5532623__F2 MET regulated signaling pathways implicated in the hallmarks of cancer 3082 6714 6774 1398 PMC5548615__F1 Emerging role of PI3K/AKT-mediated epigenetic regulation in cancer 1786 2146 5111 5371 PMC5580529__F3 Proposed model for the regulation of synaptic restructuring by Wnt during learning (from ) 2932 324 1499 PMC5584463__F1 Mechanistic target of rapamycin (mTOR): A mediator of social development 2475 3240 1243 PMC5590790__F1 Molecular mechanism underlying cardiovascular diseases associated with the changing of intracellular Ca2+ through TRPCs 7038 7225 7222 PMC5638182__F2 Mongersen, tofacitinib, filgotinib: mechanisms of action 4088 4087 3718 PMC5649483__F1 Showing a putative Th17/Treg/Th1/Th2 regulatory axis 50943 920 2625 3596 PMC5655313__F4 Role of growth differentiation factor 11 in development, physiology and disease 10272 117166 10220 PMC5659172__F3 Trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase 717 718 7295 PMC5661640__F4 General overview of the process of cell death in SMA 572 5728 2475 PMC5688955__F1 Diagram showing the various effects as well as the different pathways activated by ouabain in ADPKD cells 1080 581 6714 1956 PMC5689469__F6 Proposed mechanism of muscle immaturity in CDM 10664 1760 6774 PMC5705614__F2 Schematic depicting the hormonal regulation of the mammalian Hippo signaling pathway 4018 387 324 5879 154796 PMC5711482__F1 Targeting polyamine metabolism for cancer therapy and prevention 196743 84890 54498 PMC5714692__F2 Nutrient regulation of pancreatic Beta-cell proliferation 948 7038 4099 PMC5715147__F1 Schematic of albumin/AlbiVax nanocomplexes for efficient vaccine delivery and combination cancer immunotherapy 324 4280 325 PMC5732761__F8 Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway 6714 27035 10811 PMC5744685__F1 Targeting Metabolism for Cancer Therapy 1723 4975 1719 PMC5745276__F2b Non-Canonical Wnt Pathway and the Notch and Sonic Hedgehog Pathway-The two major non-canonical pathways are Wnt/calcium and Planar Cell Polarity (PCP) pathways 6608 387 3280 51684 1499 PMC5746412__F5 PKM2 in carcinogenesis and oncotherapy 23087 1956 2475 PMC5746573__F2 Ca2+ and ROS crosstalk between ER and mitochondria, with emphasis on redox control of the MCU 90550 8011 63933 2937 PMC5749629__F2 Hepatic methionine metabolism is closely linked to GSH synthesis 4397 635 875 PMC5771804__F4 GD T cells in homeostasis and host defence of epithelial barrier tissues 4615 4283 7097 PMC5789353__F1 Central pathway for fatty acid and cholesterol synthesis 6319 2194 47 3949 PMC5790345__F5 PD173074 inhibits the signal pathway downstream of FGFR1 in ESCC 2260 6772 2475 PMC5797008__F5 Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer 3481 6714 4763 PMC5811448__F9 Model linking the adaptive and innate immune responses during tumour development via IL-33-ILC2 axis 90865 6778 6772 4283 3627 7054 PMC5812824__F2 Gonadotropin regulation by pulsatile GnRH: signaling and gene expression 2488 2798 847 6498 2353 PMC5817861__F2 Cell signaling pathways induced by Src kinases 6714 6774 2475 PMC5825090__F1 The folate pathway in pancreatic cancer risk 7298 1719 4522 635 27232 4548 55349 4524 4552 5091 191 10400 875 1491 PMC5852508__F6 Proposed central and peripheral pathways/mechanisms being activated by circulating Ang II and high dietary salt intake 367 6651 4922 551 PMC5855797__F2 GPCR agonism bias towards insulin receptor activation 367 10682 4318 4829 3667 PMC5859860__F2 Proposed model of cross-regulation between LAP and canonical autophagy in p47phox−/− mice 7939 729 1612 PMC5863151__F1 Estrogen pathway in lung carcinogenesis and its implications for targeted therapy 1956 7852 7054 759 100187761 PMC5871897__F5 Colorectal tumorigenesis by both APC and KRAS mutations 324 3845 2932 1499 PMC5889750__F6 Acute phase signaling pathway in fish 8717 51295 2475 629 3240 3273 9373 717 PMC5899973__F3 Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis 8213 4015 7124 619501 6955 4311 PMC5905170__F1 Summary of the workflow followed in the present study 6418 4397 3423 PMC5908975__F7 FAK/paxillin/AKT signaling pathway 4313 4318 6657 595 PMC5921923__F1 Using gene expression data to direct breast cancer therapy: Evidence from a pre-clinical trial 1956 4609 387 6714 6774 PMC5943638__F1 Metformin as a Tool to Target Aging 3479 3643 3667 23411 2475 PMC5944465__F3 Quantum dots in cytotoxicity 4615 7189 114548 317 4703 PMC5955127__F3 Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells 324 1499 2305 6925 90780 2932 PMC5979464__F1 The major neuroendocrine and autonomic pathways that regulate secondary immune organs are illustrated 1392 1325 2592 PMC5985295__F5 Cooperation of unphosphorylated and phosphorylated ISGF3 and GAF components and IRF1 in the regulation of basal and IFN-induced transcription 3460 3454 3459 204 3717 10379 3659 PMC6009929__F1 Synthetic pathway for preparation of II-V [reagents; i = NC-CH2-CN, ii = (CH3CO)2CH2, iii = (NH2)2C = NH, iv = NH2NH2, v = MeI] 367 1690 1362 PMC6023503__F2 IPA pathway analysis, in which specific genes emerged throughout our review, are shown in purple 3064 51123 4703 84851 PMC6050918__F8 Proposed model for CaSR activation of NCC through a PKC-WNK4-SPAK pathway 813 26249 1638 8178 PMC6072433__F6 Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids 1571 1499 64215 PMC6079274__F2 JAK2 protein in intracellular crosstalk 2885 3667 8660 2475 PMC6095005__F2 Inflammation-associated BH4 pathway 2643 1719 5053 7054 PMC6102368__F2 Interplay between IL-6 and Notch affects the anticancer immune response 3569 3570 920 3586 7054 3565 6774 PMC6110909__F1 Direct and indirect mechanisms of action of metformin in cancer cells 6580 7249 7248 6009 2475 PMC6119869__F2 The HH signalling pathway 6608 5727 51684 PMC6131826__F6 Phosphatidylinositol signaling pathway 5728 5266 7083 PMC6139616__F1 Hepatic lipid metabolic pathways investigated in this study 29102 7038 2194 54659 47 3156 1374 PMC6141902__F1 The two commonly activated pathways and genetic aberrations involved in thyroid cancer, as well as the targeted therapies studied in thyroid cancer 238 1956 5979 5728 4763 2475 7015 7157 PMC6148086__F8 Schematic summary 7040 2475 6722 PMC6151767__F27 Asymmetric aldol/lactonization sequence for the synthesis of spirooxindole dihydropyranones 93 91653 6476 4683 PMC6178170__F10 Scheme showing a possible mechanism of the alleviated TLR-mediated inflammatory responses of macrophage U937 cells to the mycobacterial infection by coinfected A549 epithelial cells 4615 7189 2475 2932 PMC6186337__F1 In this figure, we consider potential mechanisms regulated by physical activity and caloric restriction in inhibiting the mTOR pathway 3479 3480 2475 PMC6186653__F2 Schematic diagram showing both the pathway for VEGF upregulation though EGFR/ALK gene alteration and its immunosuppressive role 1956 238 2475 PMC6216000__F1 Radiation and tyrosine kinase inhibitor resistance 2885 1956 2475 PMC6239905__F12 Metabolisms of SGG in seminiferous tubules: interrelationship between testicular germ cells and Sertoli cells 4280 410 2581 PMC6260216__F8 Scheme summarizing the protective effects of miR-27a on LPS-induced acute lung injury via the inhibiting TLR4/MyD88/NFKB activation 7099 3553 4615 PMC6260573__F7 Flavonoids downregulate mdr1 expression through wnt/Beta-catenin signaling pathway 8321 4040 324 1499 PMC6262822__F1 Parts of the signaling pathways of the five mutated proteins in the 5 syndromes of this review 846 7253 2492 PMC6263799__F1 Summary of the current model of the GET pathway 439 51608 7485 PMC6274916__F2 Complement activation by foreign biomaterial surfaces in bone tissue, and strategies to modulate the complement system 727 718 1356 9242 1378 PMC6295738__F4 The enzymes of bile acid synthesis 23600 6342 570 PMC6312990__F4 Signalling pathways related to PRL-3/EGFR/c-myc genes in cancer cells 1956 5728 6714 1445 PMC6321433__F3 Cholesterol biosynthesis deficiency syndromes 4598 5447 50814 114548 3553 PMC6321632__F2 mRNA translation stress feedback to ribosome biogenesis and cell proliferation 2475 1869 11201 PMC6323203__F1 Kyoto Encyclopedia of Genes and Genomes pathway analysis of differentially expressed proteins 717 718 727 324 8178 PMC6325590__F8 Mechanisms underlying the loss of primary cilia frequently observed in cancer cells with aberrant RTK 9101 124739 84640 159195 7347 PMC6327307__F2 Epigenetic control of CD8+ T cell differentiation 1788 1789 2638 1786 PMC6332742__F1 The central role of C1 inhibitor in various plasma systems., Upon contact with negatively charged surfaces factor XII (FXII) is (auto‐) activated to activated factor XIIa (FXIIa) 716 715 5547 5340 PMC6338478__F8 IGF-IR is now considered a functional RTK/GPCR hybrid, integrating canonical tyrosine kinase and GPCR signaling 8471 3667 8660 4193 PMC6338564__F6 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses 5728 4609 472 PMC6346075__F1 Transsulfuration pathway 4524 875 51380 PMC6357837__F7 Working model of cholestasis in Pemt+/+ and Pemt–/– mice fed the HFD 5091 10400 5205 4280 PMC6358305__F1 Schematic biochemical pathway for the production of bioactive chemical mediators leukotriene C4 (LTC4) and leukotriene B4 (LTB4) 7939 4049 4050 PMC6369476__F1 Potential proinflammatory role of resistin in the pathogenesis of osteoarthritis 7099 4615 4118 7189 PMC6384427__F2 NFKB and IRF3 signaling pathway regulation by miRNAs implicated in inflammatory diseases 4615 51135 3656 3654 8717 7189 257397 23118 7187 3661 PMC6391560__F6 Model for light input to the circadian clock network of Drosophila 64146 9427 6588 PMC6403468__F13 Model of ApoER2 and VLDLR mediated signaling during cortical development 1630 1600 1356 PMC6405305__F4 Network modeling of the epithelial-to-mesenchymal transition (EMT) 7018 6935 6469 23462 100187761 PMC6405884__F3 Schematics shown miRNAs which might regulate mGluR/mTOR/LTD signaling 5728 6009 2475 PMC6409697__F9 rLj-112 was internalized with EGFR to suppress the downstream signaling pathways to initiate the anti-tumor steps in B16 cells 1950 1956 2475 PMC6412895__F2 Signal transduction pathway of EGFR 1956 2885 2475 PMC6448643__F1 Illustration showing the activation of a T lymphocyte (via a three‐signal pathway) by an antigen‐presenting cell 958 3718 940 2475 PMC6478395__F3 BRAF mutations on tumor cell survival and the tumor microenvironment 4893 673 2475 5728 PMC6484897__F1 TLR signaling and downstream molecules 7096 7097 4615 3661 PMC6487485__F1 Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome 80270 1593 1582 25801 9420 PMC6493842__F1 Schematic representation of central histaminergic components 3067 3176 1610 PMC6515024__F1 Bone morphogenetic protein (BMP) signaling pathway and inhibition by Noggin 4090 4086 4089 PMC6520835__F1 Canonical SMO-dependent HH/GLI signaling 51684 23432 91653 6608 2736 2737 PMC6520835__F2 Genetic and molecular mechanisms conferring resistance to SMO inhibitors 51684 23432 91653 6608 2475 PMC6521150__F2 Proposed model for actinomycin D assembly (A) and 4-MHA precursor production (B) in S 717 351 718 438 727 100187761 PMC6527283__F2 Interaction of tumor-associated macrophages and cancer chemotherapy 942 6774 941 PMC6536925__F6 Relationship of the three diseases at gene, pathway, module, and function levels and the biological mechanism of T2DM, CML, and PCa 2475 390 6444 5091 PMC6543964__F2 Complement cascade and complement regulatory proteins (CRP) 718 629 3075 1675 3426 7056 1356 PMC6559733__F1 Hypothesized therapeutic role of blocking IL6 pathway in Sarcoidosis 3569 2475 3458 PMC6591470__F1 Schematic presentation of PI3K-Akt intracellular signaling 54209 5728 2885 6850 2932 PMC6596994__F7 A Conserved PLPLRT/SD Motif of STING Mediates the Recruitment and Activation of TBK1 115004 29110 3661 PMC6605362__F1 Schematic showing methionine metabolism reactions 4548 191 635 875 PMC6606950__F4 Herbal medicines promote the activation of the HIF-1 pathway through different targets in ischemic stroke 3717 2475 6774 PMC6628503__F6 Proposed model of gga- miR-1306-5p regulation on activation of pro-inflammatory responses via targeting Tollip in chickens (Red arrow: up-regulation or down-regulation) 54472 4615 3654 51135 3553 PMC6631594__F2 In the absence of Hh signal, Patched1 (Ptch1) inhibits the Hh pathway through the modulation of the Smoothened (Smo) 6469 51684 6608 PMC6642231__F1 The folates and the one-carbon cycle (1-CC) 4524 1719 875 PMC6646339__F7 Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke 3479 3704 2475 PMC6678794__F1 Delta-like ligand 4 (DLL4) and Jagged1 exert different effects on Th subsets differentiation 54567 7054 324 PMC6695603__F1 Epidermal growth factor receptor (EGFR) pathway in non-small cell lung cancer (NSCLC) 1950 1956 2066 2064 2475 PMC6698603__F6 Possible mechanism of drug resistance related to miR-326 in pediatric acute lymphoblastic leukemia (pALL) leukemic cells 6608 20 21 PMC6704952__F9 Proposed mechanisms involved in the increase of SMN expression induced by ERK inhibition in the spinal cord of severe SMA-like mice 4280 2002 6607 PMC6707069__F8 Influence of extracellular HA in erlotinib efficacy using a reductionist 3D glioblastoma model 1956 960 5728 6774 PMC6715589__F2 APP regulation of mitochondrial OXPHOS metabolism 351 3643 572 PMC6719619__F1 T-cell development 7704 30009 864 2625 PMC6721648__F2 Pathways of androgen action in the Sertoli cell 1956 6714 367 7018 PMC6728366__F7 The PCP and Wnt pathways act in parallel to establish coordinated hair cell polarity and orientation in the neuromast 7481 57216 2239 PMC6757160__F2 General mechanism of SYK activation and SYK-mediated signaling: a pathway demonstrating the involving of downsignaling associated with SYK activation 6850 114548 1080 PMC6770718__F1 Schematic drawing presents the detailed signaling pathways of breast carcinogenesis 1499 7189 4087 4088 6935 3082 1950 PMC6779479__F12 Proposed disease model of LMNA-DCM 4000 6262 817 PMC6786387__F11 Proposed model illustrating the mechanism that underlies NTZ in the amelioration of AD pathology 1728 2475 2932 PMC6789287__F7 Diagram of Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways 2932 572 842 836 PMC6815315__F1 GSK3b and growth regulation 3479 3667 324 6009 2475 PMC6816428__F1 Crosstalk between the Hippo pathway and Multi-vulval class B (MuvB) complexes 26524 1859 1874 PMC6817488__F5 AA-induced vasorelaxation and relationship to aldehyde metabolism 2638 367 217 PMC6859927__F1 Representation of normal BRAF pathway 673 5447 8213 PMC6885373__F1 DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency 51053 79923 6604 4609 PMC6894473__F3 Schematic view of the AP-1 and PKB signaling pathways between MSCs and HCC cells in inflammation microenvironment 9242 5728 7189 2475 572 619501 PMC6907065__F2 The mechanism of UVA-modulated HO-1 regulation through the PERK and Nrf2 signal pathway 9817 468 83939 PMC6923660__F8 The activation of leptin signaling pathway in preadipocytes induces adipogenesis and the production of proinflammatory cytokines 3953 857 2475 PMC6940896__F13 A sketch map of immunoregulatory induced by LTAa 4615 7189 3553 PMC6944604__F5 The roles of ADAR2-mediated RNA editing in cancer development 6581 619501 3490 PMC6954967__F8 Genes within the cGMP-PKG-Ca2+ signaling pathway altered via alternative splicing in the myocardium of DM and ChD mice 51564 4205 4209 775 9639 4659 PMC6959353__F1 Example of atom mappings of the 13C-labeling experiment used for isotopomer analysis 5091 1431 11113 4118 PMC6977166__F2 Overview of the affected pathways in the THP-1 cells after treatment with the free MTX and MTX loaded NPs 2356 2618 8836 PMC6982256__F5 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents 8408 7248 6009 PMC7003380__F1 Biology of ICOS in the tumour microenvironment 324 29851 50943 1493 7054 PMC7035310__F3 Main anatomical connections—outputs and input pathways (shown as arrows) of the zona incerta 2821 6476 1634 100187761 PMC7042886__F2 APP and ΑB Metabolism 351 1636 3416 471 PMC7052851__F1 Cholesterol biosynthesis pathway in cancer cells 38 39 3156 6713 PMC7056627__F1 LncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/Beta-Catenin Signaling Pathway 60674 27123 1499 PMC7098128__F2 Extracellular DNA in blood products and its potential effects on transfusion 54106 29110 3661 3553 PMC7115894__F4 Effect of elevated Na+ on cancer progression and the tumour microenvironment 1957 23387 5879 2744 3565 PMC7155752__F2 Signal transduction in the early Drosophila follicle stem cell lineage 1956 4313 474168 100188011 324 PMC7156858__F2 Suppressive role of MIR143‐3p in rat sarcoma (RAS) signaling pathway 1956 4893 3265 3845 4763 2475 PMC7166227__F3 Different mechanisms are triggered when stimulated by the different nucleotides in the CeCa TME 84890 1956 7372 PMC7167343__F1 Androgen metabolism scheme 7364 7367 7366 7038 PMC7177266__F4 Speculated view of the melanin synthesis pathway 4157 434 123041 6663 596 PMC7181577__F7 Proposed effect of NgR reduction on APP traffic to lysosome through Rho/ROCK2 pathway 4099 84894 4280 387 PMC7185083__F5 PTEN may regulate autophagy by allowing for a bypass of PTEN/PRAS40 signaling in TSC2-/- cells and influence cell proliferation 5728 7249 7248 6009 PMC7185488__F3 Hypothesized Human Endogenous Retrovirus (HERV)-Mediated Activation Cascades Leading to the Pathogenesis of Multiple Sclerosis (MS) 7099 324 6295 3383 325 PMC7187988__F5 Adipocyte lipolysis is implicated in disease such as diabetes, fatty liver disease and cancer 355 5346 50486 3553 5091 PMC7215558__F2 Autophagy and UPS alterations bridging altered proteostasis with neuroinflammation, the paradigm of protein glycation 2475 920 3466 PMC7216777__F1 Metabolic processing of bioactive lipids and their role in host immune response to infection 4015 26136 4050 PMC7219953__F1 Proposed mechanism of action underlying the fast and sustained antidepressant effects of ketamine 627 2475 2932 PMC7226813__F3 JNK modulates keratinocyte production of inflammatory cytokine/chemokines and recruitment of immune cells in psoriasis 3458 3491 6364 PMC7226927__F5 Action of Hedgehog signaling pathway 6608 2737 2736 PMC7232714__F8 DIFFERENTIAL ROLES AND ACTIVATION OF MAMMALIAN TARGET OF RAPAMYCIN COMPLEXES 1 AND 2 DURING CELL MIGRATION IN PROSTATE CANCER CELLS 1950 5053 253260 5879 PMC7240781__F8 Crosstalk between the adrenal steroidogenic regulatory network and the immune pathway 5241 3553 2896 PMC7244374__F1 Vitamin A uptake, transport, and metabolism 949 9227 5950 7276 64220 PMC7247696__F1 Toll-like-receptor (TLR)-4, after activation by pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) supported by myeloid differentiation factor-2 (MD-2), initiates downstream signaling in two major ways 7099 114609 4615 3654 7187 7189 3661 PMC7267004__F1 Phagocytic receptors and modulating factors functioning in the phagocytosis as well as the antigen-presenting effect to naïve T cells in teleost phagocytic B cells 613 933 54106 940 941 942 PMC7277837__F13 Hypothesized pathway for the production of prokaryotic glycolipids in C 4018 355 51083 5091 PMC7291868__F4 Common neuroinflammatory pathways in different neurological diseases regulated by miR-146a 4615 3075 3654 4397 5548 7189 PMC7305518__F5 Graphene induced activation of macrophage signaling pathway (Zhou et al 4615 7189 51135 3654 PMC7308544__F2 The metabolic interrelationships between low-density lipoprotein (LDL) subfractions and their hepatic precursors 7038 4023 1071 338 PMC7338796__F2 Crosstalk between the tetrahydrobiopterin (BH4) and kynurenine (KYN) pathways 8942 8564 6697 1719 130013 23475 PMC7343516__F8 Schematic diagrams showing the potential mechanism in the protective effects of Epothilone B on LPS induced inflammatory bone destruction 6774 100187907 1513 4772 4318 PMC7360727__F3 Shared alterations between young DS and AD brain 3667 5728 2475 2932 PMC7369933__F3 One-carbon metabolism, DNA/histone methylation, and drug interaction 1312 5212 4397 4522 4524 PMC7375019__F1 Activation of RAGE axis in Sars-Cov-2 infected cells in DM patients 3146 114548 1803 1636 3553 PMC7393681__F2 More RAS vulnerabilities, downstream 2475 4609 1025 PMC7395869__F1 Means to inhibit canonical HH, WNT and NOTCH pathways 6608 51684 5727 64840 1499 PMC7402427__F8 Summary for nuclear and cytoplasmic roles for EZH2 during osteoclastogenesis 2146 2475 9935 PMC7435717__F5 Effect of Icariin, Purmorphamine, U0126, and PD98059 on osteogenic signaling pathways 6608 1499 860 632 PMC7436626__F1 Role of H2S in lung inflammation 3553 3569 9817 PMC7456948__F1 MSCs in regulating the IL-10 producing regulatory B cells 3586 10148 9242 PMC7461113__F1 Notch signaling pathway 5045 1499 2475 PMC7465890__F10 Asp metabolism after enteral administration within the small intestine (a) and liver (b) and postulated metabolic pathway of Ala in periportal hepatocytes 4118 11113 1356 PMC7468432__F2 Activation of Breg cells 958 613 4615 3662 50615 PMC7469703__F5 CSHMM predicts the precise timing of Wnt modulation as a determinant of cell fate 11197 85407 8313 PMC7470804__F8 Proposed mechanisms for the GluOC therapeutic effects on hyperglycemia and hepatic steatosis in KKAy mice 2308 2932 355 7038 PMC7485269__F4 Role of mTOR-dependent processes in NMJ alteration upon aging 2475 1121 3479 PMC7492291__F1 Apoptotic signaling pathways triggered in CD4+CD8+ double positive (DP) thymocytes during T 920 2638 5617 5618 355 7124 PMC7503096__F1 Two common pathways implicated in thyroid cancer 5728 2475 7015 PMC7513951__F2 MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment 2475 1956 6714 2885 PMC7564116__F3 Functions of circRNAs in colorectal cancer (CRC) 1021 5209 55366 PMC7564143__F3 Four processes model of cardiac regeneration 2246 3084 5008 PMC7565746__F4 Diagrammatic representation of significantly differentially expressed genes associated with the fatty acid biosynthesis pathways, glycolysis, pentose phosphate pathway and TCA cycle when Schizochytrium was cultured under low-temperature conditions 5226 5091 355 PMC7593920__F3 The HMGB1 signaling pathway 3146 6667 6401 1356 PMC7595669__F7 Lipid metabolic pathway analysis of the identified differential lipid species 7038 5091 355 PMC7602498__F1 Homocysteine (Hcy) metabolic pathway 5212 4397 4524 PMC7602874__F2 Schematic diagram of the role of the cGAS-STING pathway in cancer immunity 6573 940 7054 PMC7606690__F4 Nef-mediated activation of Itk requires Nef homodimers 3702 920 3932 759 PMC7608107__F7 A proposed working model wherein miR-210 positively regulates microglia-mediated neuroinflammation via activating the NFKB signaling pathway by targeting SIRT1 and blocking p65 deacetylation 23411 3553 3569 PMC7651136__F9 Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer 4609 4286 2475 5728 PMC7653241__F1 S‐adenosylmethionine (SAM) biosynthesis and metabolism 4397 191 875 PMC7667862__F9 Model for OTUD7B deubiquitination of TRAF3 and inhibition of NIK to suppress LCL161-induced lung cancer cell invasion and migration 56957 958 7187 5971 PMC7680678__F1 Therapeutic strategies have been developed to target various steps in the PI3K/AKT/mTOR pathway, thereby blocking cell proliferation, growth and survival 1956 5728 2475 PMC7690394__F1 Folic acid metabolism and 5-MTHF transport across the choroid plexus epithelium in the brain 1719 10588 4397 4524 PMC7707548__F6 Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells 2638 4255 1723 3014 PMC7718059__F8 KEGG pathway enrichment of the S100 genes and their significantly related genes selected from the top 5 module analysis 4099 572 1398 PMC7723893__F2 TNFR2 activation pathway 7185 7187 5970 23118 257397 PMC7747855__F7 Astrocytic SHH signaling pathway regulates BBB integrity after ICH 6469 6608 2735 PMC7760417__F1 Virus entry initiates the interferon (IFN) response 3454 163702 7297 4615 4118 3661 PMC7761238__F1 Interaction of interleukin-2 (IL-2) and IL-15 with their receptors and downstream signaling pathways 3601 3559 3716 3718 6774 2475 PMC7761947__F3 Signaling mechanisms for TRPM2 and TRPM8 activation 7226 3603 79054 PMC7794986__F2 Molecular basis of chemoresistance in GBM 85028 6667 4255 144455 PMC7795003__F1 Growth hormone (GH) receptor 3717 3479 3486 PMC7795494__F2 Comparison between the opposite effects of probiotics and early-life use of antibiotics in NOD mice 7099 4615 4295 5350 3586 PMC7795614__F3a Comparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action 5901 10763 1104 PMC7796379__F2 Scheme of the mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN) in mice treated with paclitaxel (A) or oxaliplatin (B) 3146 6387 7852 7099 324 9015 5091 PMC7798015__F2 Complex regulation of CCN2 expression, and the diverse actions of the CCN2 protein, as reported in literature 1490 8200 6010 81501 4856 3482 1956 7450 PMC7804279__F2 The Hippo pathway in the pathogenesis of inflammatory bowel disease 9113 26524 7018 PMC7823493__F2 Synovial membrane and bone interactions in rheumatoid arthritis 3458 7124 4018 PMC7827907__F1 Updated Insights on EGFR Signaling Pathways in Glioma 1956 4763 6714 2475 PMC7833428__F6 Functional significance of activation of EGFR, IGF-1R, and B1-integrin receptor downstream signaling in wound healing 3480 1956 2885 126669 6714 PMC7838196__F10 AGE-RAGE signaling pathway in diabetic complications 1610 6401 7018 PMC7843937__F8 An overview of pathways involved in mediating Cor and DDP-induced cellular effects 2475 836 595 PMC7866651__F8 Diagram of regulated pathway in liver of GIFT exposed to acute hypoxia stress after 96 h 3630 3643 4151 3315 26330 79071 7038 PMC7874138__F6 Breast cancer by SIRT4 3569 6774 23409 PMC7886076__F4 PTEN signalling in other major oncogenic pathways 1499 5728 10761 5045 PMC7890213__F2 Nrf 2 pathway as a target in different neurodegenerative diseases 2932 3064 3575 4397 PMC7894463__F2 Lumped network of the carbon metabolism of Rhodobacter sphaeroides, including pathways for substrate uptake and product formation 1431 729 3652 717 718 1636 4118 PMC7917119__F9 Proposed model for the mechanism by which induced miR-2187 negatively regulates NFKB and IRF3 signaling expression by targeting TRAF6, thereby avoiding excessive inflammation and immune responses 57506 7189 3661 4599 9636 3553 4615 3654 51135 PMC7947196__F1 Microglial metabolic programming and immune functions in AD 2475 3091 3553 PMC7952440__F1 miRNAs flowing up and down to facilitate keratinocyte hyperproliferation 5728 9099 7078 3553 PMC7956574__F3 Wnt/Beta-catenin signaling pathway in osteogenesis 6422 6423 324 2932 1499 860 PMC7961955__F7 Common signaling pathways in liver disease (primarily HCC) and the kinase inhibitors aimed at these pathways 1956 6714 5979 2322 3815 558 2475 PMC7969947__F3 Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition 10342 238 2475 PMC7975969__F3 Suppression effect of starvation in anorexia nervosa on mTOR system and end organ results 3667 2475 6009 64798 PMC7976442__F5 Kyoto Encyclopedia of Genes and Genomes analysis of predicted pathways 554 6850 3791 771 PMC7984080__F1 Brain death‐induced lung injury is complement dependent, with a primary role for the classical/lectin pathway 729 730 735 PMC7985098__F4 Effects of statin on NLRP3 inflammasome and TLRs pathways 9973 4615 114548 PMC7996041__F5 Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery 4615 51135 3654 7189 PMC8003318__F4 Role and mechanism of miR-29a in metabolic adaptation 90632 6678 6091 23411 PMC8018932__F8 Proposed model of mToxin effects in the brain of AD mice (with emphasis upon A7AChR function) 23621 4666 342538 PMC8035226__F2 Metabolism of multiple substrates supports acetyl-CoA production in the fat cell 2194 47 55902 PMC8037234__F3 E2s participate in the DNA repair pathway 29089 5111 56254 9810 2177 55215 9025 PMC8057882__F10 Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation 2309 3014 581 PMC8062309__F2 T helper cell changes locally and peripherally in healthy pregnancy and preeclampsia 942 941 920 940 3458 PMC8071327__F1 Sphingolipid metabolism and compartmentalization 340451 10087 6418 PMC8076159__F6 Novel circGFRA1 Promotes Self-Renewal of Female Germline Stem Cells Mediated by m6A Writer METTL14 57721 389400 2674 PMC8083902__F2 Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis 65018 7038 664 PMC8125319__F2 Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma 673 2475 5728 PMC8125491__F3 Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease 1786 6622 120892 100616269 PMC8126961__F3 Is There a Carcinogenic Risk Attached to Vitamin B12 Deficient Diets and What Should We Do About It? Reviewing the Facts 4524 1719 4397 PMC8131382__F7 Hypothetical model for the regulation of cell proliferation and tumorigenesis by the Notch3ICD/PTEN axis 4854 5728 2475 PMC8138659__F2 Nkx3.1 in Cancers and Stemness 6774 6657 9314 PMC8155968__F2 Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities 5728 2475 3575 595 PMC8156589__F1 Diabetic Retinopathy and NADPH Oxidase-2: A Sweet Slippery Road 54790 1786 5879 PMC8157020__F1 Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer 2475 367 29 PMC8161134__F1 Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome? 1719 4397 4524 875 PMC8163614__F2 B2-Adrenergic receptor agonism as a therapeutic strategy for kidney disease 367 55869 65266 PMC8197226__F3 Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis 1950 284403 547 PMC8198065__F2 PLysRS-Ap4A Pathway in Mast Cells Regulates the Switch from Host Defense to a Pathological State 9242 2475 4286 PMC8219020__F1 Live-attenuated oral polio vaccine as a potential source of protection against COVID-19 – Review of literature 201633 10666 5817 324 PMC8228386__F2 FGF15 in Hepatic Surgery in the Presence of Tumorigenesis: Dr. Jekyll or Mr. Hyde? 6773 6774 2264 9965 PMC8232086__F1 Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review 4609 1499 92140 PMC8234271__F1 MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma 3815 1956 2885 PMC8237755__F2 WIP, YAP/TAZ and Actin Connections Orchestrate Development and Transformation in the Central Nervous System 1975 253260 3667 3479 6714 PMC8256442__F4 Signaling Pathways That Regulate the Crustacean Molting Gland 3643 1950 1956 6009 2475 PMC8267750__F4 Fructose and the Liver 4615 3553 114548 PMC8276676__F3 Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma 84818 717 7189 PMC8277916__F4 Computational Drug Repurposing for Alzheimer’s Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies 3569 3553 2932 PMC8296701__F1 Genistein as a regulator of signaling pathways and microRNAs in different types of cancers 6774 472 1956 2475 3845 6423 PMC8308051__F3 Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological Alpha-Synuclein Expression in an In Vitro Model of Parkinson’s Disease 1101 7450 960 948 961 PMC8313358__F2 Posttreatment Downregulation of Type III Interferons in Patients with Acute Brucellosis 324 920 3587 PMC8323643__F1 Interleukin-10: A double-edged sword in breast cancer 9021 3587 6774 7297 2932 PMC8359037__F3 Systematic summary of survival and death signalling during the life of hair follicle stem cells 6469 6608 51684 PMC8368180__F1 Inflammation and the TME in oesophageal carcinogenesis 3458 3553 3569 3586 PMC8369065__F1 Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection 324 7099 7097 PMC8395054__F3 CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy 3479 595 5925 PMC8400324__F1 Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention 5728 2475 367 PMC84049__F9 Control of LHB gene expression by Egr-1, Ptx1, and SF-1 1958 2798 847 PMC8416465__F2 How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension? 1636 6520 2475 5091 PMC8421567__F1 Emerging Role of T-Cell Immunoglobulin Mucin-3 in Breast Cancer: A Promising Target For Immunotherapy 1499 6774 10563 920 PMC8426635__F7 Tricin Biosynthesis and Bioengineering 57716 790 1312 PMC8431582__F1 From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development 7481 652 7471 9353 1908 2065 3084 PMC8435533__F7 Schematic figure showing EMP3 signaling pathway 91746 2014 2475 PMC8437142__F10 Morphine-induced inhibition of moderate acute intermittent hypoxia-induced phrenic long-term facilitation (pLTF) 627 4666 7099 PMC8440458__F2 Farnesoid X Receptor (FXR) agonists in non-alcoholic hepatitis 1581 2264 9965 PMC8454773__F1 Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals 875 100188776 4397 4524 2356 7351 PMC8458797__F1 Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway 718 727 729 966 PMC8482636__F7 Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer 64754 11185 9242 PMC8500707__F1 Genomic Landscape of HIV-Associated Plasmablastic Lymphoma 960 4609 4851 PMC8507033__F4 Preliminary construction of a regulatory network of miRNAs in the pathogenesis of nucleus pulposus degeneration - a review based on data mining 8200 7189 3654 6934 6774 7099 PMC8524770__F4 Sex hormones in lung cancer 1950 3479 3273 2475 PMC8530523__F3 Epigenetic regulation of energy metabolism in obesity 23411 51548 8473 PMC8533985__F7 Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model 387 6093 9242 PMC8556325__F1 KRAS pathway and targeted preclinical and clinical agents 1956 2885 2475 PMC8580948__F3 Inhibition of Wnt-Beta-Catenin Signaling by ICRT14 Drug Depends of Post-Transcriptional Regulation by HOTAIR in Human Cervical Cancer HeLa Cells 10664 3725 6925 PMC8582496__F4 Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement? 4090 4086 3397 PMC8582545__F1 Disruption of Tumor Suppressors HNF4A/HNF1A Causes Tumorigenesis in Liver 8717 7186 6774 PMC8607235__F5 SOCS proteins and their roles in the development of glioblastoma 9021 9846 5008 10401 1950 PMC8611092__F4 Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression 5728 3480 2475 3688 PMC8626591__F1 Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates 3146 5027 958 941 PMC8630747__F5 Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1B 6774 3091 406 PMC8631454__F8 Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice 114548 79792 3553 PMC8632384__F11 Network Pharmacology-Based Study on Irritable Bowel Syndrome Prevention and Treatment Utilizing Shenling Baizhu Powder 7372 3725 7124 6401 PMC8635802__F4 Kinase Inhibition as Treatment for Acute and Chronic Graft-Versus-Host Disease 324 5335 3707 7054 PMC8636667__F1 Biocompatibility pathways and mechanisms for bioactive materials: The bioactivity zone 7189 4772 6476 PMC8651556__F1 Endothelial Dysfunction and Hyperhomocysteinemia-Linked Cerebral Small Vessel Disease: Underlying Mechanisms and Treatment Timing 4524 4397 875 635 PMC8654269__F1 IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies 3654 4615 7189 114609 497189 PMC8655512__F2 Progranulin as a Potential Therapeutic Target in Immune-Mediated Diseases 54106 5657 6774 4303 3726 1311 PMC8657675__F4 Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance 100188864 56729 6347 PMC8659360__F1 Selective Progesterone Receptor Modulators—Mechanisms and Therapeutic Utility 140805 1950 7471 4089 4087 4088 PMC8670018__F1 T cell-associated tissues and T cell activation by RANKL-RANK-OPG 7189 326 958 4055 920 4049 PMC8686808__F2 Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe reactions to SARS-CoV-2 infection 23152 7018 920 324 4353 7450 PMC86880__F1 Receptor proximal signaling pathway for IL-1 4615 7189 23118 PMC8702415__F3 Bioactive glasses incorporating less-common ions to improve biological and physical properties 2932 1499 51199 PMC8706168__F9 Homophilic Interaction of CD147 Promotes IL-6-Mediated Cholangiocarcinoma Invasion via the NFKB-Dependent Pathway 3550 3579 3577 PMC8708448__F2 Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective 9794 4609 1026 896 2064 441478 PMC8732282__F8 Proposed model depicting the therapeutic mechanism of GRB7-PLK1 axis inhibition to overcome MEKi resistance in KRAS mutant colon cancer cells 2886 5347 6774 PMC8740689__F1 Multipurpose Drugs Active Against Both Plasmodium spp. and Microorganisms: Potential Application for New Drug Development 1725 1719 2353 5091 PMC8753976__F4 Signal transduction mechanism of exosomes in diabetic complications (Review) 7099 8650 1788 PMC8766493__F7 Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy 5091 4099 7038 2864 PMC8773762__F2 Adipose Triglyceride Lipase in Hepatic Physiology and Pathophysiology 1958 6667 23411 PMC8778078__F3 Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging 114548 3553 3606 PMC8779519__F4 Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis 5447 8027 2670 PMC8781800__F2 Current Aspects on the Pathophysiology of Bone Metabolic Defects during Progression of Scoliosis in Neurofibromatosis Type 1 4763 2885 2475 PMC8786484__F6 Study on the Mechanism of Fentanyl in Pain Treatment Based on Network Pharmacology 351 4099 978 PMC8789654__F5 Anti-Hepatocellular Carcinoma Effect and Molecular Mechanism of the Estrogen Signaling Pathway 4615 3654 3065 PMC8795506__F9 Mesenchymal Stem Cells Overexpressing ACE2 Favorably Ameliorate LPS-Induced Inflammatory Injury in Mammary Epithelial Cells 4615 7099 3553 9021 6774 PMC8809363__F1 Recent Advances in the Role of Arid5a in Immune Diseases and Cancer 7099 6772 10865 PMC8818677__F9 Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial-to-Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing IKBA 6502 8408 2475 PMC8820521__F2 Introduction to DOK2 and its Potential Role in Cancer 1445 6714 1950 1956 9046 2475 PMC8825370__F1 Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer 7099 596 1950 2475 PMC8829062__F1 Deciphering the Roles of Metformin in Alzheimer’s Disease: A Snapshot 351 23621 2475 PMC8839250__F10 Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5 93100 203447 10135 23475 PMC8841346__F1 Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System 2821 8473 10724 4760 PMC8841346__F2 Beginner’s Guide to O-GlcNAc: From Nutrient Sensitive Pathway Regulation to Its Impact on the Immune System 10724 8473 3667 PMC8859258__F4 Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients’ Stratification 64146 7124 8717 7186 PMC8874510__F1 Structural View of miRNA Biogenesis and Function 54487 29102 27161 PMC8880811__F3 The Metabolome and Non-Coding RNA on Pheochromocytomas and Paragangliomas: An Update 4763 5979 2475 PMC8894518__F1 Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy 558 1956 5728 2475 PMC8908322__F1 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? 367 7018 1956 PMC8908322__F2 What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us? 1956 367 6662 PMC8913698__F8 Co-functioning of 2AP precursor amino acids enhances 2-acetyl-1-pyrroline under salt stress in aromatic rice (Oryza sativa L.) cultivars 100653366 4942 1610 PMC8921682__F3 Decline in Liver Mitochondria Metabolic Function Is Restored by Hochuekkito Through Sirtuin 1 in Aged Mice With Malnutrition 875 55349 1581 1384 PMC8928443__F4 Association of the Microbiota and Pancreatic Cancer: Opportunities and Limitations 4615 5091 6416 5728 6774 PMC8945898__F1 Histamine Intolerance—A Kind of Pseudoallergic Reaction 1610 3067 3176 4129 PMC8964223__F3 Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn's Disease 1581 2249 9965 PMC8992566__F1 Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms 367 1325 6908 PMC8999129__F3 Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review 1499 5728 2475 6774 1956 PMC9006990__F2 Anti-EGFR Monoclonal Antibody in mCRC Maintenance Therapy 1950 1956 2475 5728 PMC9010822__F1 Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances 51684 6469 4609 PMC9022632__F2 Biology and Clinical Relevance of HCMV-Associated Adaptive NK Cells 6850 7124 3133 PMC9028087__F1 MD2 AMP(K)s up the link between lipid accumulation and inflammation in NAFLD 4615 29110 7099 PMC9029562__F4 Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase 1621 4827 7306 PMC9050318__F6 Mechanism of Osthole in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking Technology 27095 7124 598 PMC9051474__F2 Comparison of Metabolome and Functional Properties of Three Korean Cucumber Cultivars 5177 3652 8027 PMC9054782__F6 Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet 355 7124 3667 PMC9071930__F7 Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NFKB Signaling Pathway following Stimulation of the Inflammatory Microenvironment 4318 6662 860 3397 PMC9099669__F5 Demystifying the Neuroprotective Role of Neuropeptides in Parkinson’s Disease: A Newfangled and Eloquent Therapeutic Perspective 847 7124 581 PMC9114699__F1 Thyroid Cancer and COVID-19: Prospects for Therapeutic Approaches and Drug Development 5979 2475 673 PMC9138070__F1 Physical-Exercise-Induced Antioxidant Effects on the Brain and Skeletal Muscle 9817 4094 1719 4524 4397 PMC9146702__F1 An Insight into the Novel Immunotherapy and Targeted Therapeutic Strategies for Hepatocellular Carcinoma and Cholangiocarcinoma 2475 2322 7297 PMC9179253__F2 New Therapeutic Strategies for Adult Acute Myeloid Leukemia 2322 2475 2247 2260 PMC9186411__F1 Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus 6573 115004 114548 PMC9189345__F2 Research progress of endothelial‐mesenchymal transition in diabetic kidney disease 2638 6469 1499 6608 PMC9191896__F9 Pathway for sex hormone synthesis in the juvenile zebrafish 3291 1586 3283 3293 3292 PMC9195137__F3 AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications 367 7018 6714 1956 PMC9204587__F1 Cholesterol and Its Derivatives: Multifaceted Players in Breast Cancer Progression 22937 3156 2224 19 PMC9243210__F2 Metabolic reprogramming and epigenetic modifications on the path to cancer 8473 10724 2648 PMC9248717__F2 Wnt Signaling in Postnatal Tooth Root Development 387 5879 3725 847 761 PMC9250769__F1 Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis 8213 22944 4145 PMC9255247__F2 Prostate cancer stem-like cells in the development of antiandrogen resistance 324 1499 5970 6608 PMC9267745__F6 VEGFA, KRAS, and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer 2475 7422 4780 PMC9284435__F2 Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer 2177 23657 468 7045 PMC9294245__F2 Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells 57291 6608 84870 406913 PMC9326605__F1 DNA Hypomethylation May Contribute to Metabolic Recovery of Frozen Wood Frog Brains 6996 80312 54790 200424 PMC9328443__F7 SNPeffect: identifying functional roles of SNPs using metabolic networks 3652 4200 1312 PMC9331252__F6 Mulberry Leaf and Neochlorogenic Acid Alleviates Glucolipotoxicity-Induced Oxidative Stress and Inhibits Proliferation/Migration via Downregulating Ras and FAK Signaling Pathway in Vascular Smooth Muscle Cell 5111 5879 100196919 PMC9337267__F1 Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma 435 1956 2271 9817 2744 PMC9345804__F1 Molecular Alterations in Malignant Pleural Mesothelioma: A Hope for Effective Treatment by Targeting YAP 1956 2475 960 27343 921 PMC9354757__F1 Profile of Glasdegib for the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML): Evidence to Date 51684 2736 6608 2737 PMC9364625__F4 Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity 5728 50943 7019 PMC9370344__F10 Waterlogging Stress Induces Antioxidant Defense Responses, Aerenchyma Formation and Alters Metabolisms of Banana Plants 5132 84680 2077 PMC9393500__F1 Biosynthetic approaches to efficient assimilation of CO2 via photorespiration modification in plant chassis 847 4397 81888 PMC9411204__F4 Proposed biosynthetic pathway of triptonide (2) from 14-hydroxy-dehydroabietadiene (5) in S. cerevisiae 3008 51199 3009 PMC9417995__F7 Schematic description of TRAF4/SMURF2-mediated regulation of HER2 signaling and Trastuzumab resistance in HER2+breast cancer cells 9618 64750 2475 PMC9460414__F1 Plant-Derived (Poly)phenols and Their Metabolic Outcomes: The Pursuit of a Role for the Gut Microbiota 3630 1628 4155 PMC9471015__F1 Applications and prospects of genome editing in plant fatty acid and triacylglycerol biosynthesis 5132 4018 5091 PMC9476726__F9 Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer 2475 4087 4088 PMC9520460__F10 Complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment 9332 3240 718 PMC9541052__F1 Severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians 2160 7018 959 5196 7450 5340 PMC9562887__F2 “Sweet Spot” of Targeting Tumor Metabolism in Ovarian Cancers 6774 5728 2475 PMC9576590__F5 Senescence-associated secretory phenotype (SASP) 920 2475 472 PMC9576687__F2 Cellular senescence signaling pathways 545 472 4609 PMC9583131__F2 Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice 7098 3661 920 929 3553 PMC9599362__F1 NFKB Mutations in Germinal Center B-Cell Lymphomas: Relation to NFKB Function in Normal B Cells 613 5970 4055 5971 PMC9604036__F2 Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases 3553 196 3458 PMC9604112__F1 Etiology of IBD—Is It Still a Mystery? 325 324 6364 PMC9604206__F2 Molecular Targets in Osteosarcoma Treatment 3714 182 102 100188776 1956 PMC9609401__F1 Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond 4143 4524 635 4397 875 PMC9609401__F3 Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond 635 4524 1719 8566 4397 55163 PMC1446957__F5 In vitro keratinocyte mitosis 1950 126669 2885 1956 PMC2042025__F3 Notch pathway is a frequent target of insertion 5663 8650 595 PMC2078333__F1 Summary of known actions of activated ras-p21 in cells, beginning (top, left) when a growth factor binds to its cell receptor 2885 3725 2353 4609 PMC2323406__F4 Stimulus Design for Model Selection and Validation in Cell Signaling 1950 1956 2885 PMC2656900__F1 Working model for Eph receptor function in tumor promotion and tumor suppression 2064 1956 387 PMC2681728__F8 Proposed model of the role of p47 in E 2534 84333 5771 PMC2685877__F1 Combined Yeast-derived Beta-Glucan with Anti-tumor Monoclonal Antibody for Cancer Immunotherapy 940 324 958 920 7054 PMC2698936__F2 Integrins in Lens Development and Disease 3480 6714 2885 PMC2901146__F2 Taxol biosynthetic pathway 3652 735 5066 PMC2928541__F2 Wnt signaling pathway 2931 324 1499 PMC3001555__F1 Representation of the transduction pathway involved in Cd signaling 7018 914 5091 PMC3087811__F8 Schematic model for the role of TGFB signaling pathways in iTreg and Th17 cell development 4092 7049 50943 PMC3173801__F1 Many receptors modulate Wnt signalling 1499 6259 5754 PMC3183592__F1 Normal hepatic methionine metabolism 10400 5091 4397 875 PMC3218540__F2 Folate metabolic pathway 4524 875 4397 1719 PMC3226689__F7 Hole-in-One Mutant Phenotypes Link EGFR/ERK Signaling to Epithelial Tissue Repair in Drosophila 1956 2353 1644 4478 PMC3260548__F1 The signaling cascade in response to the release of dsRNA from LRV particles, production of IFNB and secretion of proinflammatory cytokines and chemokines 7098 3661 54106 51284 4615 3627 PMC3260814__F1 Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer 1956 5728 2475 PMC3264379__F9 Proposed model for regulation of HCV replication mediated by the Ras/Raf/MEK pathway 3716 7297 6773 10379 PMC3287362__F1 The anatomic and molecular mechanisms of sepsis-mediated sympathoexcitation and ghrelin's anti-inflammatory effect via sympathoinhibition 4922 23237 367 7099 PMC3288293__F1 Molecular mechanism of senescence 3569 23410 23411 PMC3315189__F1 S-ADENOSYLMETHIONINE TREATMENT OF ALCOHOLIC LIVER DISEASE: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL 4143 4397 27232 875 PMC3356019__F1 Emerging pharmacological strategies for CSCs targeting include self-renewal pathway antagonists and chemoresistance-reverting agents 1499 5727 6608 PMC3404846__F1 Mechanism of the tandem DRA/N-Boc protection proposed in this study based on the known pathway 367 91653 7054 PMC3466494__F1 GSK3 regulates a variety of pathways involved in neurodevelopment 1499 324 5266 PMC3474280__F1 Central position of the locus coeruleus in relation to the acoustic startle reflex and pupillary light reflex pathways 1431 27040 5979 PMC3488811__F1 Simplified diagram of choline-related one-carbon metabolism 4522 10400 5091 PMC3495133__F1 Schematic of the desaturation and elongation biosynthetic pathway of essential dietary fatty acids to longer chain fats 9415 2717 3992 PMC3497822__F7 The signaling pathway by which FSH promotes AKT activation in GCs 3667 9846 2638 PMC3497822__F1 The signaling pathway by which FSH promotes AKT activation in GCs 3667 9846 2638 PMC3522553__F1 Components of the Hedgehog (Hh) Signaling Pathway and molecular sites targeted by Hh pathway inhibitors 6469 6608 51684 PMC3534691__F8 Neuregulin Facilitates Nerve Regeneration by Speeding Schwann Cell Migration via ErbB2/3-Dependent FAK Pathway 2065 2064 6714 PMC3556327__F4 Cholesterol biosynthesis theme analysis 22937 3931 37 PMC3595309__F5 Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFKB signaling pathway 1015 3550 7424 PMC3642384__F2 Hypothetical evolutionary and functional relationship between Beta-catenin and nuclear transport receptors 5901 1499 4040 4041 PMC3652637__F11 Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases 1950 2885 2638 PMC3666312__F1 Current landscape for T-cell targeting in autoimmunity and transplantation 324 940 2475 1043 PMC3675894__F2 Summary of association of genetic alterations of the HH pathway and cancer type 6469 6608 51684 PMC3677135__F2 Shh and Wnts guide commissural axons in the vertebrate spinal cord 6469 64399 6608 91653 PMC3703147__F1 Ubiquitination-mediated regulation of interferon responses 3466 6772 6773 PMC3704172__F3 miR-181b and miR-146a induced in CAFs are involved in the regulation of the NFKB signaling pathway 6774 7189 3654 PMC3733232__F1 TGFBeta-mediated signaling and transcriptional regulation in pancreatic development and cancer 3553 1950 3458 PMC3798916__F1 Methylation cycle 635 875 4397 10400 PMC3827695__F4 Women and Lung Cancer: What’s New? 2885 1956 6774 PMC3847901__F3 Divergent roles of myeloid differentiation factor 88 (MyD88) in colon carcinogenesis 4615 4280 114548 171389 PMC3861981__F5 A simplified schematic diagram of the neural circuitry underlying eyeblink conditioning 5091 2638 1431 PMC3874981__F4 Schematic of Hedgehog signaling pathway 6608 2736 2737 PMC3886801__F2 STAT-3: A Molecular Hub for Signaling Pathways in Gliomas 3569 5008 2885 6774 7273 PMC3907751__F1 ROS generation and its effect on angiogenesis 5879 4353 7097 PMC3925720__F1 miR-22 in tumorigenesis 4609 407004 5728 PMC3939313__F1 Quantitative Lipid Metabolomic Changes in Alcoholic Micropigs with Fatty Liver Disease 10400 5091 7038 6319 PMC3983226__F1 Predicting Kinase Activity in Angiotensin Receptor Phosphoproteomes Based on Sequence-Motifs and Interactions 367 572 2002 PMC4000109__F2 TGFB signalling cascade alterations that lead to prostate cancer 654 4838 7040 9518 PMC4028619__F1 Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma 27232 4397 635 PMC4043666__F7 Mass Spectrometry Based Identification of Geometric Isomers during Metabolic Stability Study of a New Cytotoxic Sulfonamide Derivatives Supported by Quantitative Structure-Retention Relationships 2153 2147 2152 PMC4085546__F2 KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma 7422 4318 6608 3845 PMC4095764__F1 Physiological anticoagulant characteristics of blood vessels on endothelial cells 7018 5091 324 7035 PMC4113109__F2 Hedgehog signalling at a glance 51684 6608 5727 PMC4115292__F1 The one carbon (methyl group) metabolism in vivo 4397 27232 875 PMC4138268__F8 Schematic representation of smoke-provoked MUC1 glycosylation in regulation of MUC1-C/p120ctn interaction and adherens junction (AJ) disruption 11226 1956 6714 PMC4177473__F1 S-adenosylmethionine is produced from methionine by methionine adenosyltransferase 635 4397 875 PMC4211700__F4 PKCD and θ Possibly Mediate FSH-Induced Mouse Oocyte Maturation via NOX-ROS-TACE Cascade Signaling Pathway 374 1956 2492 PMC4232069__F2 A FOXO3-driven pathway abrogates inflammatory responses in a transforming growth factor (TGF)B1-dependent manner 2309 7040 3553 PMC4238355__F7 Model for roles of microRNAs during the reprogramming process 633 1634 7048 PMC4275311__F3 Cellular and metabolic functions for autophagy in cancer cells 7189 9817 2475 PMC4281589__F1 Retinoic acid (RA) synthesis pathway in the gut 7097 7100 941 PMC4283135__F2 Notch signaling modules relevant for brain tumors 1956 8650 100188776 3371 83737 PMC428488__F1 Outline of the Taxol biosynthetic pathway 3652 735 5066 PMC4293489__F2 Participation of CD14 in TLR4 signaling pathways triggered by sLPS and rLPS 929 7099 4615 PMC4350683__F6 Regulation of sonic hedgehog expression by integrin B1 and epidermal growth factor receptor in intestinal epithelium 1956 652 650 6608 PMC4356074__F3 Canonical and non-canonical Wnt signaling pathways 387 324 2932 PMC4393358__F1 FGF and FGFR families 3553 7083 7084 PMC4396475__F11 Casein kinase 1A–dependent feedback loop controls autophagy in RAS-driven cancers 5900 2475 664 PMC4433776__F1 HHLA2 interaction with two receptors to regulate T cell functions 324 11148 126259 PMC4445728__F1 Development and in vivo function of TH9 cells 324 7054 6778 6774 6775 3458 PMC4572253__F1 Homocysteine metabolism 635 4397 4524 875 PMC4586772__F1 Inhibitors have been developed for their ability to block Hh signaling at various signaling nodes in the pathway 6608 5727 51684 PMC4598605__F5 Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease 2885 6009 2475 PMC4611209__F1 Sporadic traditional/CIN/suppressor pathway: sequential pathological stages and molecular events 387569 324 2191 PMC4613549__F1 Proposed mechanisms of evodiamine signaling in white adipocytes 1956 2475 3667 PMC4685736__F1 Tissue‐specific function of Blimp‐1 expression in dendritic cells 64127 2638 3603 3662 PMC4714670__F4 Cooperation between RasV12 and oncogenic niche cells (ONCs) 474168 23513 7124 PMC4777991__F1 Regulation of insulin-like growth factor signaling pathway by microRNAs in hepatocellular carcinoma 3486 3480 3482 10642 10644 10643 PMC4806302__F6 Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway 6295 6469 6608 PMC4855716__F6 miRNA-gene network in the steroid hormone biosynthesis pathway and regulatory network in early sex differentiation of Nile tilapia 102465858 1585 1761 268 PMC4871813__F2 Schematic illustration of B-cell activating factor (BAFF) signaling pathway 7187 7186 7189 PMC4881503__F1 EPO-induced intracellular signaling pathways Erythropoietin and its receptor signaling through JAK2 activate multiple downstream signaling molecules including STAT5, PI3K/Akt, NFKB, and MAPK 2056 2057 3717 572 PMC4956769__F4 Features of an altered AMPK metabolic pathway in Gilbert’s Syndrome, and its role in metabolic health 54658 5225 23411 PMC4993159__F2 Hepcidin Regulation in the Anemia of Inflammation 148738 3569 6774 57817 PMC4996658__F2 Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development 4089 4087 4088 3516 PMC5004891__F4 STING: infection, inflammation and cancer 4615 3553 115004 925 PMC5034700__F1 Proposed metabolic pathway of lapatinib 1577 1576 7939 PMC5081262__F2 Major metabolic pathways in fatty acid metabolism: A) de novo lipogenesis and B) Polyunsaturated fatty acid metabolism 2194 2717 6319 PMC5103281__F2 Mechanistic cycle for silyl-mediated cross-coupling 6418 367 238 PMC524242__F1 Proposed schematic of chemokine-induced traffic and activation of DCs following DNA vaccination with plasmid-encoded Flt3L and MIP-1A 1236 941 9308 324 PMC5275750__F1 Cancer Cell Metabolism and the Modulating Effects of Nitric Oxide 7428 2475 5266 PMC5287404__F4 Roles of malyl-CoA/Beta-methylmalyl-CoA lyases and malyl-CoA lyase/thioesterases (red) in different acetate assimilation pathways: the methylaspartate cycle in H 4397 4199 4200 PMC5351412__F1 Differentiation potential of mesenchymal stem cells 9242 650 2475 PMC5486005__F1 Key miRNAs in the resistance to BC treatment 6774 5728 2475 PMC5573409__F4 Diagram of P53 signaling pathway with overlaid molecular activity prediction after heat stress 5371 100187907 367 PMC5630322__F7 Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma 1950 1956 9242 PMC5634336__F2 The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention 7173 2056 7297 3716 3717 3718 6776 6774 6775 PMC5713451__F1 Physiologic and oncogenic Hedgehog signaling 6608 5727 51684 PMC5714444__F1 Intracellular sugar-responsive gene regulatory network 23411 23387 9575 PMC5739690__F8 Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway 11274 7297 3716 10379 PMC5818912__F7 ADAM17/EGFR signaling an important player in CF and COPD lung disease 374 1956 6774 PMC5858703__F4a Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease 6774 149233 922 PMC5871897__F2 RAS-ERK signaling pathway 1950 1956 2885 PMC5920772__F3 Development and Connectivity of the Habenular Nuclei 6405 6469 9037 1630 223117 PMC5931372__F1 Clonal evolution mechanisms in NT5C2 mutant relapsed acute lymphoblastic leukemia 22978 8833 7172 PMC5966807__F4 A schematic showing the proposed signaling pathways in type II cells activated by neurochemicals at the carotid body sensory synapse 3006 24145 84890 PMC6016866__F5 The effect of the IR on the expression of the IGF-1Ec isoform 2690 3717 6774 3479 PMC6071262__F6 Schematic drawing of the 1-carbon methylation cycle 4397 4524 875 PMC6095005__F3 Mechanisms involved in the induction of depressive symptoms in inflammatory conditions (gray arrows) and potential therapeutic implications following pharmacological or nutritional interventions (blue arrows) 5053 7054 8564 PMC6134417__F1 抗表皮生长因子受体和抗血管内皮生长因子药物在非小细胞肺癌治疗中的作用 100187907 3480 1956 2475 PMC6138031__F2 Illustrative model of the IFN signal transduction pathway 3458 7297 6772 PMC6290882__F1 Hedgehog signaling pathway 5727 6608 51684 PMC6316656__F2 Hedgehog pathway activation in cancer 5727 6608 51684 3569 PMC6356247__F2 Effects of chemotherapy on coagulation activation 7018 5091 324 PMC6387269__F3 For using mTOR in PD treatment 2475 6009 5728 PMC6406365__F1 A simplified model for canonical HhP 51684 5727 6608 PMC6411369__F7 Molecular mechanism of miR-194-5p in HPC involves the mTOR signaling pathway by targeting SMURF1 57154 2475 5111 PMC6412520__F1 Simplified diagram of methionine metabolism (adapted from ) 4397 635 4524 875 PMC6471594__F2 Cilia-dependent regulation of the Hedgehog signaling pathway 51684 6608 5727 2736 PMC6584414__F1 Schematic illustration of albumin nanoparticles preparation and their targeted delivery to breast cancer cells and metastatic lymph node 594857 6608 6678 PMC6602343__F1 Developmental signaling pathway architectures sense, process and control ligands in space and time 1950 2932 6608 7018 1499 PMC6631457__F8 Schematic showing that exosomes carrying miRNAs promote NDV infection 57506 3661 3665 6772 407041 PMC6664527__F2 The canonical Wnt signaling pathway 324 1499 2932 PMC6739980__F3 Summary of ventral midline crossing 6469 64221 1630 6091 91653 658 PMC6756496__F3 Proposed signaling pathway in type II receptor cells 29850 7038 255022 PMC6776186__F6 Graphical abstract of the model of the activation of IL2RG/JAK/STAT following the overexpression of the ITK-SYK fusion gene 3561 3702 6850 PMC6778014__F1 SIRTUIN 3, ENDOTHELIAL METABOLIC REPROGRAMMING AND HEART FAILURE WITH PRESERVED EJECTION FRACTION 100616211 7157 673 PMC6836728__F5 Schematic representation of the proposed intracellular trafficking pathways of NPRA through the multi-organelle systems in cell compartments: 1601 2638 107966124 PMC6885838__F10 Effects of hydrostatin-SN10 on the JAK2/STAT3 signaling pathway 3717 7297 6774 596 PMC6896083__F2 Schematic overview of CD147 associated partner, molecular pathway and microenvironment interaction involved in cancer progression 6714 6774 8038 PMC6909742__F5 NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology 7018 9759 3065 3066 PMC6932957__F7 Hypothesized pathway of mitochondrial apoptosis activation induced by HEV infection 7432 3553 50507 PMC7174405__F1 Key proteins and important processes in vertebrate HH signaling pathway 55733 57758 84976 5727 6608 51684 PMC7198750__F5 Cell interactions in TME engaging the cGAS-STING pathway 115004 355 325 PMC7335982__F6 Signaling pathways and deregulation of its modalities such as Stat3/mTor, Hedgehog, Notch and Wnt/-catenin cascade defined as a new therapeutic strategy in the prevention of cancer extension, especially CSCs growth behaviors modification () 6608 1499 324 PMC7407119__F1 The major sources of reactive oxygen species (ROS) in the cell and the corresponding inhibitors of those sites 50507 1723 30001 PMC7481292__F5 Summary of effects of TCDD on OCM gene expression and metabolites 4144 27232 1757 635 191 875 PMC7492390__F3 Complement-dependent mechanisms of antibody mediated rejection 727 718 966 7450 PMC7499322__F2 Promotional roles of MSC-derived exosomes in tumors 9242 100616251 9965 PMC7607850__F1 ZA inhibits the RANKL/RANK pathway 7189 2475 4772 PMC7609840__F1 Relevant JAK-STAT signaling pathways in the pathogenesis of Spondyloarthritis 149233 3594 7297 3717 3718 3716 6772 6775 6774 PMC7678304__F3 Literature-based illustration of TNFA signaling pathway in the presence and absence of macrophages 6774 841 842 PMC7681022__F1 Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism 7298 2618 4524 4397 PMC7769953__F1 IL-6 signaling pathway and inhibitory agents 3569 6714 6774 PMC7797663__F1 Central pathway of cancer cachexia involving GDF15 and GFRAL with RET proto-oncogene as a coreceptor 9518 389400 5979 4922 PMC7894481__F8 Scheme representing the effect of FGF2 on the activity of connexin hemichannels and consequences on ATP release and proliferation of cultured tanycytes 4852 2247 2260 PMC7896234__F1 Mechanisms underlying microglial response to peripheral inflammation.(A) Schematic representation of the signaling pathway underlying changes in microglial Ca2+signaling, induced by peripheral inflammation 3553 7226 114548 PMC7914561__F1 Methionine cycle 4397 635 4524 PMC7956574__F2 BMPs and TGFB signaling pathways in osteogenesis 4087 4088 8195 64750 57154 9759 860 PMC8014339__F7 F528 treatment ameliorated smoke-induced inflammation and emphysema through NFKB signaling pathway 4313 4318 3569 PMC8108463__F3 Endogenous retroviruses in the origins and treatment of cancer 7098 57506 3665 PMC8165262__F1 Interleukin-27 and Its Diverse Effects on Bacterial Infections 3716 7297 10148 PMC8178558__F1 Innate type 1 immune response, but not IL-17 cells control tuberculosis infection 51428 115004 29110 3661 PMC8201405__F3 Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms 7097 4615 7189 54106 3665 7187 3661 7098 PMC8221351__F9 Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/Beta-catenin pathway 89780 1499 23621 PMC8227424__F1 4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer 6007 5966 920 PMC8231807__F1 FGFR Inhibitors in Oncology: Insight on the Management of Toxicities in Clinical Practice 3845 673 2475 1591 9965 PMC8351592__F2 Type I Interferon Induction in Cutaneous DNA Damage Syndromes 3661 115004 11277 PMC8507016__F3 Wnt/Beta-catenin signaling pathway in the pathogenesis and treatment of multiple myeloma (review) 3574 6348 55366 3569 PMC8508836__F7 Survival Motor Neuron Gene Expression by Calcium Signaling 7038 814 8683 PMC8529064__F5 Microbiota in Infant Health: From Early Life to Adulthood 92610 3045 100187828 7189 PMC8568584__F7 Direct modulation of hepatocyte hepcidin signaling by iron 6774 4090 4086 654 50507 PMC8624316__F1 Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition 1788 1789 6996 PMC8668794__F3 Gene expression and epigenetic responses of the marine Cladoceran, Evadne nordmanni, and the copepod, Acartia clausi, to elevated CO2 635 27232 4524 PMC8698202__F1 Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms 4615 29110 3661 3665 PMC8820534__F1 High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats 51380 875 27232 1491 6821 7263 635 58472 PMC8835057__F8 Cytokine Receptors—Regulators of Antimycobacterial Immune Response 7297 3716 6774 PMC8835057__F9 Cytokine Receptors—Regulators of Antimycobacterial Immune Response 3716 7297 6772 6774 PMC8900217__F2 DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling 115004 6367 324 PMC8912934__F3 Tinker, Tailor, Tumour Suppressor: The Many Functions of PRP4K 1956 2475 5728 PMC8918554__F9 The functions of NR2F1-AS1 in pancreatic cancer 441094 2475 7025 PMC8945563__F2 Immunotherapy for SMARCB1-Deficient Sarcomas: Current Evidence and Future Developments 115004 57506 29110 PMC8996945__F2 Prognostic Role and Significance of Dll4 and Toll-like Receptors in Cancer Development 182 3714 28514 100188776 PMC9170780__F4 Bone pain: Progress in research from bench to bedside 387 1630 9242 PMC9185618__F2 Targeting the methionine addiction of cancer 4524 875 635 4397 191 27232 4507 PMC9266892__F1 Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus 324 2932 387 PMC9281973__F1 Benefit–risk assessment of sonidegib and vismodegib in the treatment of locally advanced basal cell carcinoma 6608 51684 5727 PMC9313121__F4 Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia 100170220 5864 6616 PMC9313337__F3 Comparing Bayesian-Based Reconstruction Strategies in Topology-Based Pathway Enrichment Analysis 3716 7297 3717 3718 PMC9405832__F1 MTHFR SNPs (Methyl Tetrahydrofolate Reductase, Single Nucleotide Polymorphisms) C677T and A1298C Prevalence and Serum Homocysteine Levels in >2100 Hypofertile Caucasian Male Patients 875 4524 4397 1719 PMC9539794__F6 Triptolide in the treatment of systemic lupus erythematosus - regulatory effects on miR-146a in B cell TLR7 signaling pathway in mice 51284 4615 3654 PMC9540480__F1 Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need 3665 51284 51311 PMC9577175__F1 Activation of NOD1 and NOD2 in the development of liver injury and cancer 10392 8767 64127 114803 331 7189 PMC9605422__F9 Research Progress on Fungal Sesterterpenoids Biosynthesis 3652 685 140805 PMC4277955__F1 Interleukin-22 signaling pathway 7297 3716 6774 PMC5412537__F1 Diagram of IL-10 and IL-10R pathway 7297 6774 3716 PMC8429033__F7 Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver 6774 7297 595 PMC9670319__F4 RNA-seq and qRT-PCR analyses reveal the physiological response to acute hypoxia and reoxygenation in Epinephelus coioides 2641 1103 2642 2475 2778 2776 2695 5163 5836 2147 23235 5315 7959 5447 23089 PMC9630750__F2 Drosophila melanogaster as a model to study innate immune memory 4615 1386 5966 8772 PMC9695301__F3 Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer’s Disease: Dietary Plant Polyphenols 7099 729230 3553 PMC9675141__F6 Antioxidant and anti-inflammatory activities of Centratherum anthelminticum (L.) Kuntze seed oil in diabetic nephropathy via modulation of Nrf-2/HO-1 and NFKB pathway 9817 581 4512 PMC9688074__F7 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases 2524 100124700 1499 7099 3553 PMC9693028__F3 Antioxidant Properties of Hemp Proteins: From Functional Food to Phytotherapy and Beyond 9817 847 3553 PMC9632491__F7 Protein phosphorylation in cell signaling, disease, and the intervention therapy 4478 2002 7039 197259 114609 834 4615 PMC9632491__F5 Protein phosphorylation in cell signaling, disease, and the intervention therapy 1950 1956 2885 5058 7124 8717 7186 PMC9632491__F4 Protein phosphorylation in cell signaling, disease, and the intervention therapy 4170 1499 4609 993 5111 1019 1021 1874 1869 2079 1080 PMC9632491__F8 Protein phosphorylation in cell signaling, disease, and the intervention therapy 374654 1499 3014 100313892 4609 51701 3696 PMC9632491__F1 Protein phosphorylation in cell signaling, disease, and the intervention therapy 1311 572 29984 5879 5728 7249 PMC9632491__F3 Protein phosphorylation in cell signaling, disease, and the intervention therapy 8717 7124 7186 2002 5080 1616 4149 2475 545 596 672 4609 PMC9658148__F3 Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology 4838 6469 6495 7020 5080 5307 4990 1749 2290 5309 3856 2488 3861 1410 PMC9669388__F2 Astragalus and its formulas as a therapeutic option for fibrotic diseases: Pharmacology and mechanisms 4092 1499 23411 2932 9817 2879 4851 759 4087 4088 8650 3611 79792 114548 7099 7124 355 581 6761 90865 4312 PMC9681860__F2 Copper homeostasis and cuproptosis in health and disease 2242 2230 11019 1737 PMC9684800__F4 Roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors 2475 5163 3654 3397 1499 27302 4090 4086 324 6714 5062 2050 PMC9686346__F3 Health benefits of Nigella sativa on diabetes mellitus and its complications: A review from laboratory studies to clinical trials 7038 4025 581 3479 PMC9688074__F1 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases 7099 102464837 7189 PMC9688074__F8 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases 7045 388341 283120 7503 114548 3553 PMC9700492__F5 Transcriptomic and metabolomic insights into the role of the flgK gene in the pathogenicity of Pseudomonas plecoglossicida to orange-spotted grouper (Epinephelus coioides) 4046 5971 3553 4772 4775 1959 1960 3586 6850 5336 801 PMC9900921__F7 Simplified de novo sphingolipid biosynthesis pathway 2531 2581 7357 6476 410 79152 PMC9621223__F2 Short Sleep Duration and Erectile Dysfunction: A Review of the Literature 4852 2638 387 PMC9622720__F4 Network exploration of gene signatures underlying low birth weight induced metabolic alterations 613 930 6850 3667 5879 5728 5163 951 7249 572 4193 6009 51083 672 4609 5934 150365 PMC9632491__F6 Protein phosphorylation in cell signaling, disease, and the intervention therapy 4485 85451 11186 2322 2885 1950 1956 6714 3667 10379 8027 2022 4067 6850 PMC9633658__F1 Muscle-specific MicroRNAs in patients with chronic obstructive pulmonary disease and skeletal muscle dysfunction 406904 3479 2475 627 6722 PMC9641156__F3 Novel insight into the functions of N6-methyladenosine modified lncRNAs in cancers (Review) 54915 2638 619501 56339 5091 PMC9646750__F1 Advances in multi-omics study of biomarkers of glycolipid metabolism disorder 1499 6934 3767 1803 80339 6833 PMC9647469__F3 Didang Tang inhibits intracerebral hemorrhage-induced neuronal injury via ASK1/MKK7/JNK signaling pathway, network pharmacology-based analyses combined with experimental validation 3320 5468 6714 7157 836 1499 3725 5743 4846 4318 4609 2875 5465 841 6517 3791 842 3551 2908 2904 1437 4843 5566 891 5241 3553 PMC9652280__F4 Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome 8205 27040 1636 5891 PMC9653672__F6 Analysis of RIOK2 Functions in Mediating the Toxic Effects of Deoxynivalenol in Porcine Intestinal Epithelial Cells 847 6667 581 55781 PMC9658791__F3 Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury 22926 7494 468 PMC9664769__F5 Disinfectant dodecyl dimethyl benzyl ammonium chloride (DDBAC) disrupts gut microbiota, phospholipids, and calcium signaling in honeybees (Apis mellifera) at an environmentally relevant level 859 627 1756 PMC9671909__F6 Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models 8518 5864 7054 PMC9674149__F7 Kyoto encyclopedia of genes and genomes (KEGG) signaling pathway map 1103 100188011 7939 6955 PMC9678611__F4 Prediction of network pharmacology and molecular docking-based strategy to determine potential pharmacological mechanism of Liuwei Dihuang pill against tinnitus 7099 3939 4703 1610 7428 717 2056 7018 100306940 2160 9241 7037 226 PMC9681860__F1 Copper homeostasis and cuproptosis in health and disease 9973 6647 475 538 540 1317 10063 6341 1353 PMC9682773__F2 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development 196 1543 208 PMC9682773__F3 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development 406 196 7038 PMC9686558__F3 Ameliorative Effect of Tocotrienols on Perimenopausal-Associated Osteoporosis—A Review 9817 9978 8452 847 PMC9687456__F8 m6A Methylation Analysis Reveals Networks and Key Genes Underlying the Coarse and Fine Wool Traits in a Full-sib Merino Family 613 930 3667 5728 7249 5894 572 6256 4193 5934 4602 51083 PMC9687725__F6 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media 4117 8163 3313 821 PMC9688074__F3 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases 55384 114548 283120 6774 PMC9693344__F3 Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma 581 1616 8772 22926 PMC9696247__F1 Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia 26291 664 65018 PMC9696358__F2 Methylglyoxal in the Brain: From Glycolytic Metabolite to Signalling Molecule 8989 351 836 PMC9696821__F6 Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics 5230 2821 5315 226 PMC9697017__F6 Integrating Network Pharmacology and Transcriptomic Strategies to Explore the Pharmacological Mechanism of Hydroxysafflor Yellow A in Delaying Liver Aging 2641 2776 1998 108 1610 5447 5266 2147 3270 5350 4397 5315 90550 11113 100187907 258010 200186 5465 6402 4118 220134 8161 2875 PMC10025411__F1 Neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and neuroinflammation 468 57761 7494 581 22926 PMC9180620__F6 Could a Lower Toll-like Receptor (TLR) and NFKB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron? 5045 7113 59272 7124 7098 51284 3661 3665 7099 4615 7097 PMC9180978__F3 Soluble Epoxide Hydrolase and Diabetes Complications 59341 468 581 4703 50507 7124 114548 7412 1003 PMC9282724__F3 Models of autophagy dysfunction in neurodegenerative diseases 1362 10133 203228 6622 120892 29110 8301 11315 5071 65018 2521 25978 29978 7415 55737 79890 23646 8398 8867 23607 54209 2896 9896 23400 PMC9322180__F1 Genetics in Familial Intrahepatic Cholestasis: Clinical Patterns and Development of Liver and Biliary Cancers: A Review of the Literature 2264 9965 8213 1581 4851 5091 54532 1080 PMC9488186__F1 Promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis 7249 6009 64798 8408 6446 PMC9604538__F5 Interactions between pathogens and LAP/CASM 8673 9140 9474 55054 PMC9611857__F2 A Pathological Interaction between Beta-amyloid and Mitochondria in the Occurrence and Development of Alzheimer’s Disease 4976 9927 55669 51024 PMC9622871__F8 Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions 4151 6120 2752 PMC9623337__F1 New insights into Chlamydia pathogenesis: Role of leukemia inhibitory factor 2885 2549 3716 3976 3977 6774 9021 PMC9623415__F2 PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer 2475 1019 5163 207 2932 1499 1385 PMC9626530__F2 Therapeutic potential of triptolide and celastrol in neurological diseases 23621 3579 2475 4803 627 3717 PMC9626809__F1 Sulfur compounds in chronic obstructive pulmonary disease 847 875 79587 PMC9628250__F2 The Wnt signalling pathway in the energy metabolism of bone remodelling 847 948 2744 PMC9630107__F3 Glucose metabolism proteins regulated by Src 2534 2539 6714 2821 2147 2597 3099 5209 PMC9630603__F4 Intersection of stem cell biology and engineering towards next generation in vitro models of human fibrosis 4088 4087 4089 9242 PMC9630654__F1 Meta-analysis indicates that the regulation of cell motility is a non-intrinsic function of chemoattractant receptors that is governed independently of directional sensing 387 6010 998 54434 PMC9631428__F1 Research progress on microRNA in gout 4615 51135 7189 9839 1969 114548 100126320 PMC9633954__F2 Pattern recognition receptor signaling and innate immune responses to schistosome infection 6850 114548 3603 PMC9634082__F2 Ubiquitin modification in osteogenic differentiation and bone formation: From mechanisms to clinical significance 2263 867 9618 64750 9736 4086 57154 3726 4089 7375 6737 9099 650 6502 10626 11060 860 8239 4087 4734 83737 5970 54532 2736 78990 7855 91445 1499 23133 7874 10297 991 83844 7189 PMC9636637__F2 Iron metabolism in chronic diseases related to obesity 8031 148738 6102 6520 2879 3651 23657 PMC9637655__F1 Dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology 7494 1375 10724 PMC9637655__F3 Dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology 9759 7494 50507 4968 2475 115201 9342 5978 4087 217 948 PMC9639813__F6 Key neuronal signalling pathways are downregulated in fast growing in vivo juvenile liver fluke 5447 6855 5185 8139 PMC9641750__F6 Mitigation of Multi-Organ Radiation Injury with ACE2 Agonist Diminazene Aceturate 1636 59272 3586 PMC9641939__F6 Effects and related mechanism of alpha-adrenergic receptor inhibitor phentolamine in a rabbit model of acute pulmonary embolism combined with shock 5350 759 367 PMC9644577__F2 Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation 324 1499 128486 PMC9652569__F5 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking 842 4988 5328 3725 1869 1544 4313 6256 3553 5578 3565 1950 5599 3458 3162 3486 7422 3481 581 595 2353 4609 4843 6257 2099 207 836 7153 860 8972 4353 4069 6347 4792 5925 5594 5579 1509 1401 4312 11200 1956 2100 1432 5465 1026 596 4318 6590 6401 3315 3576 3558 5970 3569 2920 6696 5894 3791 4314 1111 3586 6647 3551 890 4846 1147 598 959 3627 196 3552 1576 5467 2944 1543 PMC9653341__F3 Immune response associated with ischemia and reperfusion injury during organ transplantation 4851 6367 6361 PMC9654339__F3 In Vivo Models for Prostate Cancer Research 10499 7468 5728 8405 367 2078 2115 PMC9654339__F4 In Vivo Models for Prostate Cancer Research 4193 4609 10481 5728 672 4255 79611 PMC9654339__F5 In Vivo Models for Prostate Cancer Research 238 4316 1499 324 8767 4609 4149 2535 6774 10006 5728 673 PMC9654827__F8 Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma 6622 6620 4905 PMC9654982__F1 Advancements on the Multifaceted Roles of Sphingolipids in Hematological Malignancies 6611 95 9350 64781 PMC9655337__F6 Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis 7124 7099 4615 7189 PMC9656133__F6a Integrated Multi-Omic Characterization of the Detachment Process of Adherent Vero Cells with Animal-Based and Animal-Origin-Free Enzymes 5182 51056 5184 PMC9657665__F1 Cellular Senescence in Metabolic-Associated Kidney Disease: An Update 23411 1017 1019 1021 PMC9657779__F10 Regulatory Role of Sphingosine-1-Phosphate and C16:0 Ceramide, in Immunogenic Cell Death of Colon Cancer Cells Induced by Bak/Bax-Activation 581 8877 7186 PMC9658128__F4 Emerging Effects of IL-33 on COVID-19 90865 54106 51135 3654 7189 51284 4615 7187 3665 5132 920 3553 6761 PMC9659297__F4 Biological Relevance of Papaverine in Cancer Cells 2475 253260 1950 5728 6010 5163 PMC9663387__F1 Optogenetic interrogation of cell signalling: human neuropsin (hOPN5) represents a potent tool for controlling the Gq pathway with light 4827 51083 7225 PMC9663996__F5 ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis 3146 114548 3553 79792 4615 PMC9672095__F4 Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer’s disease with metabolic syndrome 3416 6622 4023 7939 3643 351 671 1636 324 90550 4508 28 7124 23063 PMC9674404__F3 Signaling condensates in the B cell receptor pathway 613 6850 8161 PMC9675355__F5 Regulators of nucleotide excision repair (NER) in melanocytes 1910 545 4157 7507 406 9575 7508 PMC9676213__F7 MS-proteomics provides insight into the host responses towards alginate microspheres 325 5648 5340 5624 7448 7035 629 3075 1675 1191 1401 717 720 3426 PMC9681554__F9 Melatonin Suppresses Macrophage M1 Polarization and ROS-Mediated Pyroptosis via Activating ApoE/LDLR Pathway in Influenza A-Induced Acute Lung Injury 942 383 79792 114548 PMC9681929__F3 Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression 6041 2475 207 102464837 4609 596 PMC9682161__F2 Prostaglandin E2 in neuroblastoma: Targeting synthesis or signaling? 1956 2885 6714 2475 4041 4040 324 2932 1499 PMC9683337__F2 Receptor activator of nuclear factorKB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds 7189 126014 100187907 1513 4772 2729 847 56954 9049 9817 PMC9684248__F2 Pyroptosis in inflammation-related respiratory disease 1283 284110 55876 56169 79792 1687 PMC9687725__F2 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media 2695 666 4318 2788 6237 29909 1950 PMC9687725__F3 Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media 7139 815 4620 PMC9688074__F6 Long Noncoding RNAs in the Regulation of Cellular Immune Response and Inflammatory Diseases 7503 7099 1432 3553 79576 7189 440823 406939 100507316 PMC9688300__F1 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease 8473 10724 200186 5105 355 PMC9688300__F2 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease 3667 2932 5163 PMC9688300__F3 O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease 8473 7494 6722 5159 11035 7032 619501 PMC9688888__F9 Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway 8772 637 581 595 3146 3569 6774 PMC9691967__F3 Tailoring biomaterials and applications targeting tumor-associated macrophages in cancers 594857 8205 958 920 613 2152 4261 8685 PMC9692235__F2 Transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation 7088 4609 595 2290 79094 672 2064 999 PMC9693344__F2 Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma 9817 9978 1728 PMC9694790__F4 Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases 1647 596 581 331 1019 1021 1017 PMC9695474__F3 Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions 57506 7187 3661 7098 51284 7189 1956 4615 3665 3659 7297 6773 10379 PMC9697478__F13 Immunomodulatory Effects of an Aqueous Extract of Black Radish on Mouse Macrophages via the TLR2/4-Mediated Signaling Pathway 6774 7099 7097 3603 PMC9706101__F2 Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors 6446 2308 10397 2309 10725 7249 65266 149233 7124 PMC9708800__F4 Targeting inflammasome-dependent mechanisms as an emerging pharmacological approach for osteoarthritis therapy 23411 3553 114548 84973 4615 3654 51135 7189 834 3606 79792 7874 50507 PMC9709153__F6 Molecular mechanisms of exercise contributing to tissue regeneration 7078 5728 2475 23411 595 596 204851 112597 54798 406904 9759 6722 7003 11016 407010 4088 50964 10554 PMC9709755__F3 Transcriptome profiling of colorectal tumors from patients with sepsis reveals an ethnic basis for viral infection risk and sepsis progression 51422 57521 5528 5527 3646 171177 6229 391 4622 4624 6217 2475 1356 5595 8660 8153 8672 6231 7423 468 1387 5521 3611 55742 4625 2932 6133 836 3690 5608 9349 72 6169 7414 3694 6136 6128 4791 23521 6181 6130 6154 6464 6144 59 PMC9832433__F2 Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis 3939 5209 2147 4353 7099 7412 3383 2308 PMC10028837__F1 The oxidative phase of the pentose phosphate pathway including 6-phosphogluconolactonase (Pgl), that converts 6-P-gluconololactone to gluconate-6-P 5814 5813 5640 3034 7054 4049 2353 PMC7613831__F4 DMT induces a transcriptomic signature promoting FAO and opposing fibrosis in the renal cortex of ZDF and ZDSD rats 140805 5091 176 183 22937 5465 5468 10370 51 1962 PMC8423867__F3 N-terminal acetylation and lysine acetylation 8520 55140 1386 9575 6872 114799 157570 4261 9085 8888 3065 3066 10014 10013 8841 55869 51564 83933 23411 22933 23410 23409 23408 51548 51547 PMC8423867__F4 The protein acetylation in regulation of cancer-associated events 5105 2308 2113 207 6502 5728 472 6773 10379 PMC8473587__F1 p53 regulates glucose, lipid, amino acid, nucleotide, and iron metabolism 23657 440 4609 8833 6240 6241 84889 2147 57103 5209 26227 3099 3098 5105 5106 5163 5164 53354 7857 2395 2232 54677 2242 57817 187 81894 PMC8492792__F1 Conserved Hh signal transduction pathway 6608 55733 374654 51684 27148 25989 156 8405 PMC8629847__F1 MyD88 Signaling Leads to Cell Specific Functions in Cardiovascular Disease 4615 3146 3553 51135 3654 3656 3663 3665 7189 7187 3661 PMC9099719__F2 Tumour Stem Cells in Breast Cancer 8205 7097 6347 6387 9474 3091 3569 6402 23152 100187761 PMC9246651__F1 Cellular communication network factor 1 by Ras homolog family member A in bovine steroidogenic luteal cells 9113 26524 3973 387 6722 3491 PMC9273332__F1 Single-cell deletion analyses show control of pro-T cell developmental speed and pathway by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b 6688 4211 3205 53335 10486 582 2078 6932 2625 64919 10487 960 3815 PMC9363460__F1 Non-exhaustive representation of lipid metabolic pathways addressed in the review 948 1376 47 355 4099 PMC9489100__F2 Lung involvement in monogenic interferonopathies 5159 51816 55768 472 115004 57506 29110 3661 1777 25939 11277 10379 6772 6773 1314 7297 3454 3455 11274 9636 51371 54 PMC9604538__F2 Pathways for ATG16L1-mediated conjugation of LC3 to membranes during autophagy and LAP/CASM conjugation via the V-ATPase-ATG16L1 axis 7405 7939 22863 55054 26100 9474 64422 10533 9140 PMC9620778__F8 MAPK signaling pathway. The red nodes represent CN–NI-related genes 246744 355 929 51083 7186 1616 8161 4149 351 PMC9623297__F2 Regulatory roles of circular RNAs via autophagy in ischemic stroke 5163 7248 7249 6009 664 2932 2021 PMC9623391__F1 Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease 8942 8564 23475 130013 6697 PMC9623415__F1 PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer 5163 207 2475 PMC9623991__F2 Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer 3190 6294 10211 2319 2147 4023 382 5338 11031 6714 3371 1956 64857 56848 998 5879 PMC9623991__F6 Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer 24145 2913 100170220 3187 7224 6774 84876 6786 8773 9066 PMC9626530__F3 Therapeutic potential of triptolide and celastrol in neurological diseases 23621 2475 7124 7097 3146 114548 6761 90865 PMC9627214__F2 Necroptosis: A new target for prevention of osteoporosis 7124 8717 7186 8737 3553 8772 197259 11035 PMC9628128__F1 Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications 5209 2147 5315 1956 1950 5728 4609 3845 3099 1499 324 PMC9628250__F3 The Wnt signalling pathway in the energy metabolism of bone remodelling 50964 5163 324 4041 1499 2932 6934 PMC9628328__F1 IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NFKB–Induced Inflammation 7189 10454 23118 7099 4615 7097 10333 3654 PMC9630328__F2 Tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors 201633 8205 928 3458 6367 6352 100507436 4277 7124 1233 6347 3576 6387 6774 558 PMC9633197__F7 Molecular Mechanism of Epimedium Extract against Ischemic Stroke Based on Network Pharmacology and Experimental Validation 5624 3976 7054 6770 3630 PMC9634253__F2 Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer 1263 2475 6774 9112 472 PMC9634419__F4 Human stefin B: from its structure, folding, and aggregation to its function in health and disease 27185 2475 2932 1499 PMC9634734__F1 BMP4 in adipose-derived stem cell differentiation: A minireview 652 25805 659 PMC9635865__F1 Recent advances in postoperative pulmonary rehabilitation of patients with non-small cell lung cancer (Review) 5290 1832 7015 7473 2944 1499 4318 PMC9636380__F1 Activation of RIPK3 by multiple stimuli 7098 7099 81030 8737 11035 6737 5495 57162 197259 PMC9636624__F4 Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation 3158 7316 5360 1581 4312 PMC9640569__F6 Genomic control of inflammation in experimental atopic dermatitis 85480 90865 7422 PMC9644706__F3 FADD as a key molecular player in cancer progression 8772 100187761 596 PMC9647849__F4 Mass spectrometry‐based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways 28 6693 51083 6622 847 90550 581 PMC9648670__F1 Interaction between gut microbiota and immune checkpoint inhibitor-related colitis 5212 3553 7097 1401 PMC9650235__F3 IL-7: A promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines? 3716 581 572 4170 3718 2308 PMC9650603__F2 FOXK2 transcription factor and its roles in tumorigenesis (Review) 2353 3725 3607 25942 80312 8314 3066 8819 580 1499 PMC9650829__F2 Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside 1499 4072 51176 6868 2274 1956 1950 1000 79923 6657 PMC9652569__F1 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking 3725 7124 5970 2353 4792 4117 PMC9652569__F7 Hedysarum multijugum Maxim treats ulcerative colitis through the PI3K-AKT and TNF signaling pathway according to network pharmacology and molecular docking 3725 5970 7124 PMC9652818__F1 N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting 8663 558 11211 56339 79068 5137 9474 10024 57721 54890 79923 3717 3206 51441 54915 10642 90427 23650 6722 55236 PMC9652818__F3 N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting 857 56339 9589 57721 79068 10481 54890 6657 3480 54915 51441 10642 11240 23035 55615 2475 79899 3667 400550 23089 6659 PMC9652895__F7 Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer 3569 3717 6774 3570 468 581 596 PMC9654823__F6 Equus Beta-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage 3553 7097 6850 6347 PMC9655262__F4 Necroptosis: A Pathogenic Negotiator in Human Diseases 8737 11035 197259 PMC9655277__F1 Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease 1893 5741 6098 5879 2475 PMC9657596__F6 Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway 595 5315 3939 PMC9657829__F4 DNA Methylation in Neurological Diseases 351 56940 5663 23621 672 PMC9657829__F6 DNA Methylation in Neurological Diseases 5649 1788 54790 4204 55777 100188776 84890 132 PMC9658128__F2 Emerging Effects of IL-33 on COVID-19 90865 2919 2920 4353 958 941 PMC9658582__F5 Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson’s Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis 5447 6622 90550 7054 7454 831 PMC9658772__F2 E3 Ligases in Cervical Cancer and Endometrial Cancer 1956 23608 5728 4089 4087 4088 6502 1499 54894 10346 64127 5930 2273 201292 4193 8870 100187761 PMC9659230__F5a Reprograming of Gene Expression of Key Inflammatory Signaling Pathways in Human Peripheral Blood Mononuclear Cells by Soybean Lectin and Resveratrol 581 3458 8651 3659 3437 10379 PMC9659858__F1 Clinical implication of genetic composition and molecular mechanism on treatment strategies of HER2-positive breast cancers 6347 3569 581 596 5728 5058 5163 7248 7249 595 1019 1021 1869 PMC9659888__F1 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer 79792 114548 3553 7124 8737 8772 6774 56169 1687 55876 PMC9659971__F3 Immunometabolism in the tumor microenvironment and its related research progress 5105 2194 8205 23409 948 11035 PMC9663521__F7 Protein tyrosine kinase 6 regulates activation of SRC kinase 1956 6714 5753 PMC9664061__F1 Promising research direction for colorectal cancer immunotherapy: The regulatory mechanism of CCL5 in colorectal cancer 7124 6352 1230 1499 9242 6774 8205 3627 PMC9668530__F2 Recent advances in understanding the metabolic plasticity of ovarian cancer: A systematic review 2539 5209 3939 3418 7351 PMC9669439__F2 Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma 3845 382 3099 3098 3939 2194 47 2746 587 586 2744 9230 3620 PMC9669513__F2 Effect of oncogenic activation of RAS signaling in OC 1956 2475 2885 6774 PMC9671114__F6 Changes and significance of gut microbiota in children with focal epilepsy before and after treatment 4668 572 6476 7523 4118 PMC9672132__F1 Investigation of the physiological response of radiation-induced cystitis patients using hyperbaric oxygen 3162 7124 4843 627 5743 3553 5594 4803 1392 6863 3586 7422 6648 6387 3725 3569 3552 4908 7032 142 5595 3565 1270 6352 2147 PMC9679345__F2 Gap Junction–Mediated Transport of Metabolites Between Stem Cells and Vascular Endothelial Cells 4118 9241 150365 100187761 4340 947 9242 PMC9682092__F2 LncRNAs involved in regulating the RIG-I signaling pathway 152225 6421 8168 55601 7706 57506 3661 3665 2944 84740 7297 10379 100506668 105221694 3454 100126791 104326052 3455 4117 3716 6772 6773 PMC9682773__F4 Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development 196 405 7038 PMC9682817__F3 Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2 4041 4040 324 5879 PMC9684248__F1 Pyroptosis in inflammation-related respiratory disease 4615 114548 10628 140609 3606 929 3146 79792 1283 PMC9684248__F6 Pyroptosis in inflammation-related respiratory disease 7099 114548 7097 22861 1283 79792 PMC9684248__F7 Pyroptosis in inflammation-related respiratory disease 2735 1283 56169 79792 3569 6774 1687 PMC9685566__F9 Transcription level differences in Taxus wallichiana var. mairei elicited by Ce3+, Ce4+ and methyl jasmonate 998 5879 1616 5894 4342 2316 PMC9685729__F2 Noonan syndrome: improving recognition and diagnosis 867 2885 5781 22808 8036 4763 6016 8216 8452 161742 PMC9685814__F2 From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders 627 43 590 PMC9686310__F6 A muscle cell and the proteins linked to protein turnover and quality control 64374 10049 9531 22954 3920 203547 57724 8878 PMC9686909__F2 Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia 355 581 8772 637 7124 PMC9686959__F2 Ferroptosis and Its Potential Role in Glioma: From Molecular Mechanisms to Therapeutic Opportunities 2182 10162 2879 6520 PMC9687343__F4 Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment 1499 4040 59272 2475 183 PMC9687343__F5 Cancer Metastasis and Treatment Resistance: Mechanistic Insights and Therapeutic Targeting of Cancer Stem Cells and the Tumor Microenvironment 1499 4513 1636 PMC9687482__F4 Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets 351 4035 348 PMC9687758__F10 Genome-Wide RNA Sequencing of Human Trabecular Meshwork Cells Treated with TGFB1: Relevance to Pseudoexfoliation Glaucoma 4092 4087 4088 4086 64398 154796 4089 9113 324 374 174 6657 PMC9687868__F3 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis 3091 4969 2475 4771 1956 2060 1950 PMC9688625__F7 Targeting Wnt/Beta-Catenin Signaling Exacerbates Ferroptosis and Increases the Efficacy of Melanoma Immunotherapy via the Regulation of MITF 1499 4286 3458 2879 PMC9688663__F1 Advances in Understanding of Metabolism of B-Cell Lymphoma: Implications for Therapy 6714 6850 695 4609 26227 6470 1719 7298 6472 4967 PMC9688668__F2 Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy 2885 3667 5266 5728 7249 6009 7124 64798 PMC9688771__F2 Sweet Warning: Mucin-Type O-Glycans in Cancer 6714 8729 51083 PMC9688847__F1 Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1A/PPARA Players 6472 2731 4507 6470 4524 6723 6611 4548 875 191 PMC9689226__F8 Overcoming Anxiety Disorder by Probiotic Lactiplantibacillus plantarum LZU-J-TSL6 through Regulating Intestinal Homeostasis 100506013 8862 718 727 51083 2925 10874 4295 8620 4852 4922 3060 5020 6750 6866 2862 5021 6865 6870 10911 551 5367 3972 2837 2834 2492 7253 7200 4018 5724 7201 1392 2695 2691 2641 5741 6343 7432 799 6344 3952 5617 7442 2908 3953 PMC9690286__F1 Small Non-Coding RNAs in Human Cancer 29102 5901 192669 4553 PMC9692093__F2 RNA modification in the generation of acquired drug resistance in glioma 2146 2760 11166 79923 554203 79068 5163 6023 84133 145258 4609 103 10643 PMC9692235__F6 Transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation 4609 7088 3195 3280 7091 5728 1540 57801 596 2322 7090 2296 3065 PMC9692683__F2 SARS-CoV-2-Induced Amyloidgenesis: Not One, but Three Hypotheses for Cerebral COVID-19 Outcomes 2670 6285 1401 114548 PMC9694790__F2 Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases 4615 7189 3553 PMC9696119__F5 Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID 51311 59272 7098 51284 7189 7099 4615 7187 29110 57506 3661 3665 3455 3716 6772 3659 10379 3454 7297 6773 163702 PMC9697247__F1 Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases 2932 324 1499 4041 23554 8434 PMC9698307__F1 Emerging Direct Targeting Beta-Catenin Agents 4041 4040 1499 324 607 PMC9699238__F8 Fascaplysin Induces Apoptosis and Ferroptosis, and Enhances Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) by Promoting PD-L1 Expression 23657 468 2879 581 596 PMC9699619__F2 Renin–Angiotensin-Aldosterone System, Nitric Oxide, and Hydrogen Sulfide at the Crossroads of Hypertension and COVID-19: Racial Disparities and Outcomes 875 1636 59272 PMC9700348__F1 Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via A6B1 Integrin-Fyn-RhoA-ROCK Signaling 999 5879 6010 2534 PMC9700862__F8 Overall mechanisms involved in CNNM4 overexpression caused by APAP overdose 22926 468 26504 7494 7124 PMC9701405__F6 Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure 4313 7045 4314 6347 7424 3082 4846 7124 1269 2064 126669 5447 2321 5972 183 1636 1401 285 8139 PMC9701576__F3 Racial disparities in prostate cancer: A complex interplay between socioeconomic inequities and genomics 367 1499 324 1628 3169 1105 5728 7314 3110 7113 2078 2194 7043 6002 PMC9701731__F1 Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination 4763 10215 6663 5156 116448 627 PMC9702548__F7 The effects of HFPGE on the immune response in RAW 264.7 cells 7189 7124 3627 PMC9705310__F8 Schematic diagram of the proposed divergent effects of astrocyte-specific Cp knockout on learning and memory function 1356 3240 7018 581 PMC9705325__F7 Proposed antitumorigenic mechanism of CPX on GC growth 6714 6774 1019 595 2638 PMC9705593__F1 Crucial role of T cells in NAFLD-related disease: A review and prospect 3627 6364 6774 2833 619501 PMC9706587__F9 Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy 961 140885 3258 1436 340451 PMC9709153__F3 Molecular mechanisms of exercise contributing to tissue regeneration 3084 6722 3479 3480 2475 163732 627 PMC9709205__F3 Impact of SOX2 function and regulation on therapy resistance in bladder cancer 9462 3484 3481 6657 4513 PMC9710158__F1 Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells 1435 6347 1437 8205 9332 650 4254 729230 968 140885 961 PMC9726313__F8 Network-based pharmacology and molecular docking exploring the “Bupleuri Radix-Scutellariae Radix” mechanism of action in the viral hepatitis B treatment 8717 7186 7187 197259 8772 4703 83737 840 2920 355 8809 9021 3726 64127 6401 3383 PMC9832433__F4 Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis 7097 7099 324 5091 3603 4353 7018 PMC10153643__F2 Thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans 255738 3949 4023 PMC7706582__F4 Epigenetic Mechanisms in Leukemias and Lymphomas 10113 613 2322 5079 5781 1879 10320 472 23451 1106 4851 595 7157 7186 8085 604 4853 7128 355 8915 970 567 10892 727 596 4615 58508 718 1387 100271849 2146 5728 8740 10672 9308 387 6446 4792 84433 6774 4794 673 1029 5925 717 4609 3399 6597 79718 10365 7187 329 27086 4023 973 974 3492 896 4094 2261 3662 PMC8492792__F4 Multiple strategies for inhibiting Hh signal transduction pathway 55733 51684 6608 23476 PMC8542015__F3 Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model Organism Caenorhabditis elegans 10399 5163 207 65095 1499 PMC8643334__F1 Hepatitis B Virus e Antigen and Viral Persistence 7124 3553 7097 PMC8895352__F2 Androgen receptor (AR) signalling pathway associated PC IncRNAs (Adapted from Aird et al. ) 728606 144481 64002 100124700 285463 100126354 101978785 145837 104472713 1487 6774 3569 PMC9050958__F8 Interferon-gamma Induces Melanogenesis Via Post-Translational Regulation of Tyrosinase 4254 1499 4286 4157 7306 1638 3459 3460 3716 3717 3458 6772 4397 PMC9149051__F2 Figure 2:. Adaptive response programs in tumor cells and in the tumor ecosystem 3667 2475 1956 983 7465 1017 472 545 3014 5888 672 PMC9189572__F10 Longitudinal intronic RNA-Seq analysis of Parkinson’s disease patients reveals disease-specific nascent transcription 468 4508 7466 7186 100506742 100187907 258010 9978 6500 PMC9189572__F11 Longitudinal intronic RNA-Seq analysis of Parkinson’s disease patients reveals disease-specific nascent transcription 468 1869 3725 717 4149 7942 7030 10133 PMC9220817__F1 Blood Cell-Derived Microvesicles in Hematological Diseases and beyond 7018 929 930 4353 928 1043 960 PMC9488681__F1 Pulmonary hypertension associated with neurofibromatosis type 1 4763 7248 7249 6009 2475 PMC9488999__F1 Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? 65018 57506 260431 114548 3553 PMC9525271__F8 ADH1C inhibits progression of CRC by ADH1C/PSAT1/ serine metabolic pathway 5723 26227 29968 126 PMC9525711__F7 Schematic depicting the role of TLB on AD 7189 23410 7099 4615 PMC9613427__F1 Gain-of-function TLR7 and loss-of-function A20 gene variants identify a novel pathway for Mendelian lupus and lupus nephritis 4615 613 3665 51284 PMC9621617__F4 Alterations in bone fracture healing associated with TNFRSF signaling pathways 9242 860 4772 8772 PMC9627224__F1 RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral 7124 2353 3725 7099 1998 1997 54106 1999 3659 PMC9627342__F3 Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma 3091 5163 4151 PMC9628250__F1 The Wnt signalling pathway in the energy metabolism of bone remodelling 9242 7480 7477 PMC9629402__F7 In Silico and In Vitro studies of taiwan chingguan yihau (NRICM101) on TNFA/IL-1Beta-induced human lung cells 7124 3929 7189 929 2353 2002 3725 6885 10454 7186 9261 1277 3569 7130 3576 PMC9630328__F1 Tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors 6774 50943 920 PMC9630567__F1 Involvement of endoplasmic reticulum stress in rifampicin-induced liver injury 468 9817 7494 PMC9633631__F3 Lung fibrosis: Post-COVID-19 complications and evidences 1499 324 7018 4323 4316 PMC9635866__F6 Realgar-induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis 3845 2182 2879 PMC9635867__F1 RNA m6A methylation regulators in endometrial cancer (Review) 2475 51441 10481 56339 57721 2159 23035 54915 595 9589 857 3480 1277 6657 400550 3667 10642 23089 6659 PMC9635867__F2 RNA m6A methylation regulators in endometrial cancer (Review) 5728 56339 57721 5163 23035 51441 7248 7249 6009 PMC9638168__F2 MicroRNAs in Kawasaki disease: An update on diagnosis, therapy and monitoring 6774 28 56674 5159 3572 693160 4318 7078 5515 581 4091 4092 4117 9314 PMC9639265__F1 Endoplasmic reticulum stress targeted therapy for breast cancer 7494 468 22926 PMC9639265__F2 Endoplasmic reticulum stress targeted therapy for breast cancer 7494 468 6774 7124 PMC9639265__F3 Endoplasmic reticulum stress targeted therapy for breast cancer 7494 2475 468 6935 999 22926 PMC9639265__F4 Endoplasmic reticulum stress targeted therapy for breast cancer 7494 4609 3091 468 PMC9641109__F7 Identification of candidate hub genes correlated with the pathogenesis, diagnosis, and prognosis of prostate cancer by integrated bioinformatics analysis 2947 2950 2946 1577 2949 2944 2330 316 290 5743 6241 3760 2878 5730 5742 5740 776 3764 1910 4882 3779 800 801 94274 477 1305 894 4638 10398 1288 7414 4311 858 1298 1280 1311 56034 2318 7060 7422 857 3691 3914 9899 6387 7043 3109 284 6347 PMC9641212__F1 Immune response induced by novel coronavirus infection 7124 3659 836 840 90865 197259 PMC9641390__F3 Targetable vulnerability of deregulated FOXM1/PLK1 signaling axis in diffuse large B cell lymphoma 2305 4193 253260 7852 7019 2956 4436 983 10397 995 5111 891 6657 5347 472 545 6774 7270 29904 3488 558 4854 3485 3280 PMC9641401__F5 Krüppel-like factor 6 splice variant 1 in the development, diagnosis, and possible treatment strategies for non-small cell lung cancer 1316 7291 6369 581 999 1000 PMC9643007__F10 Stromal contributions and potential therapeutic agents 9837 51659 64785 84296 3815 596 472 673 6714 266710 4350 PMC9647533__F7 MicroRNA-16 inhibits the TLR4/NFKB pathway and maintains tight junction integrity in irritable bowel syndrome with diarrhea 7099 7503 3569 3553 PMC9647636__F10 Crosstalk between TBK1/IKKE and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury 8177 7099 29110 3661 3716 7297 6772 PMC9655901__F3 Interplay between Autophagy and Herpes Simplex Virus Type 1: ICP34.5, One of the Main Actors 115004 29110 3661 57506 5111 9817 708 PMC9656839__F8 High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role 3480 8660 3667 7248 7249 6009 2475 5163 5224 PMC9656973__F7 Visfatin-Induced Inhibition of miR-1264 Facilitates PDGF-C Synthesis in Chondrosarcoma Cells and Enhances Endothelial Progenitor Cell Angiogenesis 2475 56034 100302251 PMC9657949__F1 MicroRNAs in HER2-Positive Breast Cancer: Where We Are and Future Prospective 693120 406988 4170 407006 100616132 574506 4603 2309 3481 3667 PMC9658244__F2 IL-33/ST2 Pathway in Cerebral Malaria 3553 958 941 942 3567 90865 6761 PMC9658491__F4 Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review 7046 4092 64750 4088 4087 4089 860 1749 4086 4090 4091 4322 PMC9659888__F2 Noncoding RNA-mediated regulation of pyroptotic cell death in cancer 100506305 9447 100316868 60674 22861 114548 79792 3553 100507098 55384 84973 7503 399972 4827 283131 PMC9659959__F1 Nucleic acid-sensing toll-like receptors: Important players in Sjögren’s syndrome 81622 7098 7187 29110 51311 7189 3661 3665 51284 4615 54106 PMC9659971__F2 Immunometabolism in the tumor microenvironment and its related research progress 29933 7124 8205 9123 4609 PMC9661764__F5 ERAlpha-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer 2078 2729 1244 9429 5243 960 PMC9663482__F9 Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3B/Beta-catenin/ZEB1 Signaling Pathway 2932 1499 6935 PMC9664042__F1 Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1B 90865 79792 3553 PMC9664406__F4 Mitochondrion-targeted RNA therapies as a potential treatment strategy for mitochondrial diseases 4553 85495 6023 2926 60674 101927152 PMC9667311__F2 Ultrahigh resolution MS1/MS2-based reconstruction of metabolic networks in mammalian cells reveals changes for selenite and arsenite action 2539 5226 2821 8405 7054 7086 PMC9669913__F6 Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NFKB signaling pathway 7124 1280 6662 PMC9671940__F2 Growth stimulation expressed gene 2 (ST2): Clinical research and application in the cardiovascular related diseases 90865 51135 7189 PMC9675361__F1 DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study 472 5893 675 10111 4361 7516 5888 7517 PMC9675776__F9 GediNET for discovering gene associations across diseases using knowledge based machine learning approach 8828 213 7498 253260 31 581 4609 7157 472 5728 7422 1147 7372 5328 1950 PMC9677642__F7 Identification of crucial genes and metabolites regulating the eggshell brownness in chicken 54977 9429 2235 23456 1371 5498 210 3145 7390 7389 PMC9681929__F2 Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression 5514 6773 9958 64778 4293 4208 27107 6695 100616495 23019 PMC9682092__F1 LncRNAs involved in regulating the RIG-I signaling pathway 1283 7706 57506 7187 29110 3661 3665 PMC9682092__F3 LncRNAs involved in regulating the RIG-I signaling pathway 55000 5820 8847 57506 29110 3661 3665 PMC9682817__F4 Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2 717 4089 4086 406940 103504737 406915 100302237 PMC9684248__F3 Pyroptosis in inflammation-related respiratory disease 55876 1283 114548 3553 5198 79792 9447 7099 PMC9684248__F4 Pyroptosis in inflammation-related respiratory disease 1431 1283 114548 79792 10628 PMC9684653__F3 Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma 7249 2475 4193 472 6790 PMC9684661__F1 Immunometabolism in the pathogenesis of vitiligo 5132 2539 4283 3627 58191 847 PMC9687868__F2 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis 4969 1499 1956 PMC9687982__F1 Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury 22861 9447 58484 PMC9688046__F2 USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective 4193 50943 7874 PMC9688694__F1 Antitumor Activities of Interleukin-12 in Melanoma 3594 6774 6775 3595 3662 3717 6772 100996569 3659 3559 PMC9691885__F1 Determinants regulating Toxoplasma gondii bradyzoite development 2026 1469 2023 PMC9691885__F2 Determinants regulating Toxoplasma gondii bradyzoite development 3458 4280 920 8841 PMC9697406__F1 Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer 10274 7015 23657 8289 113791 301 4436 2475 545 10013 2146 3066 7525 PMC9698586__F3 Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets 1374 5901 948 7038 PMC9699340__F3 Constitutively Active Androgen Receptor in Hepatocellular Carcinoma 367 1499 2289 23239 2932 7249 PMC9700707__F6 In silico and in vitro analysis of microRNAs with therapeutic potential in atherosclerosis 4023 10577 5360 948 100187907 PMC9702353__F8 Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NFKB/NLRP3 signaling pathway 942 7124 114548 79792 PMC9706580__F8 Mutant Kras and mTOR crosstalk drives hepatocellular carcinoma development via PEG3/STAT3/BEX2 signaling 3845 7248 2475 5178 6774 84707 PMC9709075__F6 Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus 831 87178 25939 4940 3456 3440 4939 10581 8519 PMC9709153__F2 Molecular mechanisms of exercise contributing to tissue regeneration 9780 4485 10014 50964 4041 4040 PMC9709153__F4 Molecular mechanisms of exercise contributing to tissue regeneration 3084 2064 595 4088 11201 1019 PMC9709224__F7 Oleic acid-induced steatosis model establishment in LMH cells and its effect on lipid metabolism 7038 2194 4547 338 PMC9709406__F6 Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity 5728 2475 1956 2885 PMC9709420__F6 Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation 3034 8772 847 351 4117 PMC9949995__F2 Transgenerational epigenetic inheritance of axonal regeneration after spinal cord injury 2348 1719 4524 4397 PMC9981633__F1 Targeting matrix metalloproteases in diabetic wound healing 4851 6387 4283 3627 58191 942 941 7077 4312 PMC10150895__F2 Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers 1000 554203 1499 10663 2638 7291 999 7422 894 2475 6659 PMC10242330__F2 Autophagy: A challengeable paradox in cancer treatment 6009 7248 7249 596 22863 55626 PMC10242642__F1 SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia 10278 25939 978 1635 22978 1633 51727 6240 6241 PMC10278599__F2 CAR T cell cytolytic mechanisms and paracrine effects 355 3458 7124 PMC8647629__F1 The Renin–Angiotensin System in the Cancer Stem Cell Niche 4513 545 1499 1636 PMC8817700__F1 Targeting Toll-Like Receptors in Sepsis: From Bench to Clinical Trials 7096 114609 51284 51311 3146 3654 4615 54106 7097 51135 3665 10333 7100 3661 7098 29110 7099 PMC8872633__F4 Protein cysteine palmitoylation in immunity and inflammation 920 3932 7535 3702 27040 5335 PMC9240418__F6 Molecular checkpoints of distorted autophagy pathways in lupus nephritis 22863 55054 9140 9474 65018 5071 8408 60673 2475 9776 10533 64422 PMC9273281__F1 Senescence-associated secretory phenotype in ovarian cancer dissemination 84444 3148 57721 56339 115004 PMC9343382__F1 Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe? 10135 203447 93100 23475 130013 PMC9489161__F2 Immunological and toxicological risk assessment of e-cigarettes 3383 3553 3569 PMC9620658__F1 Targets of aspirin in bladder cancer: bioinformatics analysis 4792 4609 7157 5111 1909 595 5743 836 834 PMC9621333__F1 Epstein–Barr virus infection, B‐cell dysfunction and other risk factors converge in gut‐associated lymphoid tissue to drive the immunopathogenesis of multiple sclerosis: a hypothesis 613 2592 3123 920 PMC9621439__F2 Mammalian and basal innate immune signaling via NFKB 115004 3665 3661 PMC9628242__F6 Tetrahedral framework nucleic acids promote diabetic wound healing via the Wnt signalling pathway 1499 51176 595 7422 PMC9632420__F7 Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel’s activity by suppressing the NF-kB signaling pathway 1956 9101 999 1000 PMC9633314__F5 Fibroblast growth factor receptor 3 overexpression mediates ALK inhibitor resistance in ALK‐rearranged non–small cell lung cancer 27436 238 2261 PMC9633631__F4 Lung fibrosis: Post-COVID-19 complications and evidences 9113 26524 558 374 332 182 PMC9637482__F8 Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis 6774 3717 9242 960 PMC9638655__F1 Blood-based biomarkers for diagnosis, prognosis, and severity prediction of COVID-19: Opportunities and challenges 7098 7124 59272 920 999 3383 7412 8174 PMC9643775__F2 New insights into iNKT cells and their roles in liver diseases 355 958 940 941 942 961 140885 3383 PMC9651967__F7 Integrated proteomics and phosphoproteomics revealed druggable kinases in neoadjuvant chemotherapy resistant tongue cancer 998 207 286 5590 9322 3895 9669 1656 5058 4650 23365 387 3858 11187 3848 9462 5581 5595 5594 8428 2011 2309 5879 5598 5924 6446 1794 9053 PMC9652939__F9 MICAL1 facilitates pancreatic cancer proliferation, migration, and invasion by activating WNT/Beta-catenin pathway 64780 23216 8324 324 8312 2932 1499 PMC9653480__F6 Obesity downregulates lipid metabolism genes in first trimester placenta 7038 4023 51 5465 PMC9655342__F3 Targeted Therapies in Advanced and Metastatic Urothelial Carcinoma 2065 2260 2263 2264 2066 2261 2885 6009 7248 7249 5058 331 4193 PMC9657162__F8 Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood–Milk Barrier 114548 9474 55054 9140 PMC9658244__F3 IL-33/ST2 Pathway in Cerebral Malaria 6347 3627 90865 3553 3383 6761 PMC9658487__F5 Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses 595 5728 2475 PMC9658491__F5 Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review 1499 2932 324 PMC9658645__F3 Monocyte, a Maestro in the Tumor Microenvironment (TME) of Breast Cancer 284340 7422 6678 6362 83394 1950 1435 PMC9659209__F1 Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target? 7018 3065 3066 574493 10370 22880 960 PMC9663420__F6 P2RX receptors and inflammatory markers in SCZ 12 5025 114548 5027 PMC9663828__F6 Tumor suppressor DEAR1 regulates mammary epithelial cell fate and predicts early onset and metastasis in triple negative breast cancer 4087 4088 6591 PMC9679411__F6 Delamanid suppresses CXCL10 expression via regulation of JAK/STAT1 signaling and correlates with reduced inflammation in tuberculosis patients 3717 3627 100187761 PMC9681083__F9 Schematic for the plausible mechanisms by which PI3K pathway inhibition mediated the anti-leukemic activity of FD268 AML cells 2475 572 581 PMC9682092__F4 LncRNAs involved in regulating the RIG-I signaling pathway 100302692 84740 3665 57506 PMC9682745__F3 Innate immunity, cytokine storm, and inflammatory cell death in COVID-19 7124 6772 3659 81030 8737 PMC9684248__F5 Pyroptosis in inflammation-related respiratory disease 7099 114548 9447 1283 1687 79792 PMC9684248__F8 Pyroptosis in inflammation-related respiratory disease 9447 1283 10399 10628 114548 PMC9687478__F1 Antiviral Innate Immune Responses in Autoimmunity: Receptors, Pathways, and Therapeutic Targeting 115004 29110 3661 4615 7096 7097 10333 51135 7189 3654 3656 3665 7099 57506 51284 51311 54106 7098 PMC9688773__F8 Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology 1717 1718 3156 5091 5833 10400 PMC9693644__F1 Epha2 Receptor Blockers Involved in Cerebral Malaria from Taraxacum officinale, Tinospora cordifolia, Rosmarinus officinalis and Ocimum basilicum: A Computational Approach 3383 85451 6347 7124 4049 1969 1003 PMC9695027__F3 NTRK Gene Fusions in Solid Tumors and TRK Inhibitors: A Systematic Review of Case Reports and Case Series 2885 2549 5163 2475 PMC9695749__F7 Mulberry Leaf (Morus alba L.) Extracts and Its Chlorogenic Acid Isomer Component Improve Glucolipotoxicity-Induced Hepatic Lipid Accumulation via Downregulating miR-34a and Decreased Inflammation 2194 23411 5465 PMC9696608__F1 Immunotherapeutic Implications of Toll-like Receptors Activation in Tumor Microenvironment 4615 3661 7098 7187 PMC9698582__F11 G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells 9283 5591 2475 1786 PMC9703992__F6 Cub pathway 83786 6868 5045 1956 6237 2885 5566 5971 2768 5970 PMC9704080__F8 13-Acetoxysarcocrassolide induces apoptosis in human hepatocellular carcinoma cells through mitochondrial dysfunction and suppression of the PI3K/AKT/mTOR/p70S6K signalling pathway 572 581 2475 PMC9704363__F5 Noncoding RNAs in cancer lipid metabolism 2194 2475 100187761 728655 5465 5914 2180 PMC9704363__F6 Noncoding RNAs in cancer lipid metabolism 2194 47 3156 2180 2182 6713 2744 100423013 PMC9704760__F5 An example paths-between query to find the two distinct directed links between two simple chemicals in the Urea cycle pathway with k = 7 5471 4942 445 5009 162417 435 PMC10100231__F7 Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGFB1 signaling 4088 4087 4089 7040 1499 PMC7612806__F1 Simplified schematic of the KYN pathway 3620 8564 8942 PMC8492792__F3 Hh signaling in cancer 5727 23432 6608 51684 PMC8627558__F2 Dynamic and cell-specific transport networks for intracellular copper ions 538 475 540 PMC8638406__F8 IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases 920 84818 2919 6374 3579 PMC8647428__F1 Osteochondroma Pathogenesis 7482 54361 6469 5727 4040 4041 8325 4090 4086 3549 1499 PMC8647434__F1 Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer 3091 7424 5155 7422 80310 5159 5629 PMC8714987__F8 Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension 9780 4854 182 4851 PMC9491642__F1 Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma 6778 3718 3597 7297 3717 196 PMC9552028__F1 Organoids as a Model System for Studying Notch Signaling in Intestinal Epithelial Homeostasis and Intestinal Cancer 102 3280 474 PMC9643771__F1 Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer 3661 29110 115004 PMC9646327__F8 Virtual Screening and Network Pharmacology-Based Study to Explore the Pharmacological Mechanism of Clerodendrum Species for Anticancer Treatment 2099 2261 1956 7157 960 2950 836 675 3265 672 2475 3320 6790 4312 367 238 4318 3791 2321 5170 8161 3717 5290 8743 5241 5618 7048 354 7015 5578 6714 5315 11200 PMC9650140__F1 Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis 1277 6502 655 6774 PMC9666114__F1 MP0274, a Novel DARPin Therapeutic Targeting Human EGFR2 Signaling in Breast Cancer After Prior Trastuzumab and Pertuzumab 572 2309 2475 619537 PMC9672378__F1 Myeloid and lymphoid cell development by O-glycans on Notch 4851 1950 182 28514 54567 102 9794 PMC9684661__F2 Immunometabolism in the pathogenesis of vitiligo 2833 6772 4283 3627 PMC9685408__F2 Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation 1108 2113 2114 5629 54345 2303 64321 PMC9688731__F3 Extracellular Vesicles in Multiple Myeloma—Cracking the Code to a Better Understanding of the Disease 9242 100187907 4318 7852 1956 374 860 PMC9692129__F7 Spatiotemporal characteristics of P-selectin-induced B2 integrin activation of human neutrophils under flow 6850 695 5336 3383 5906 PMC9697024__F8 Apigenin Ameliorates Hyperuricemia and Renal Injury through Regulation of Uric Acid Metabolism and JAK2/STAT3 Signaling Pathway 3717 6774 9021 PMC9707496__F2 Dysregulation of FBW7 in malignant lymphoproliferative disorders 6774 2033 1387 PMC9658955__F8 LMNA Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial–Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling Pathway 1956 1950 6935 PMC9832176__F2 TGFB signaling in the placenta via miR-574–5p mediated SMAD2/4 regulation 4089 4087 4088 PMC9395173__F1 Using human data on cardiovascular risk associated with T1DM to guide mechanistic studies in mouse models 345 6279 6280 PMC9666723__F8 Digital gene expression profiling of the transcriptional response to Sclerotinia sclerotiorum and its antagonistic bacterium Bacillus amyloliquefaciens in soybean 84916 51096 55272 92856 55813 5822 6949 10528 4809 51602 9790 28987 27343 11201 10436 55651 1736 55505 6023 5901 51068 55341 4733 PMC10036296__F1 An Evolving Understanding of the Basis and Management of Vascular Complications of COVID-19: Where Do We Go From Here? 59272 3383 7450 1401 PMC10085880__F7 In silico identification of potential miRNAs -mRNA inflammatory networks implicated in the pathogenesis of COVID-19 554212 6850 7098 6773 23118 7187 114548 4703 3586 3661 10379 100187761 103 PMC10124776__F1 Pig heart and lung xenotransplantation: Present status 51083 324 961 140885 3133 PMC10140937__F4 Mitochondrial DNA Supplementation of Oocytes Has Downstream Effects on the Transcriptional Profiles of Sus scrofa Adult Tissues with High mtDNA Copy Number 7187 10486 3122 3119 8801 1738 4967 4200 6392 3418 3421 4191 1743 6391 2271 10873 1431 PMC10148080__F4 NAT10 as ac4C writer in diseases 55226 1017 595 1019 9859 581 PMC10148099__F7 Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease 1738 18 593 594 316 197322 4151 1629 26275 3033 11112 586 587 4329 84693 6389 6390 2271 5095 5096 4190 4191 8802 8801 55902 79611 35 1431 50 4967 1962 3420 3155 5162 5166 134526 2194 1737 PMC10149906__F1 Building on the backbone of CD47-based therapy in cancer: Combination strategies, mechanisms, and future perspectives 325 115004 140885 4035 961 PMC10150574__F3 Signaling through the phosphatidylinositol 3-kinase (PI3K)/AKT pathway 6774 2885 6714 1956 998 5879 4193 5728 2475 2932 572 PMC10151377__F3 Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases 619501 133 10533 574473 1499 283120 PMC10151765__F2 Generation, activation, and polarization of monocyte-derived macrophages in human malignancies 355 8772 2534 142 PMC10239259__F2 Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy 3667 2475 154075 11059 28999 PMC10241773__F2 Epigenetic regulation and therapeutic targets in the tumor microenvironment 23358 2146 56339 4088 6347 3627 54915 958 941 1237 1236 6279 383 4283 8205 79885 10013 64863 PMC10242070__F5 Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages 196 6774 54106 6692 3659 169355 7100 3663 3661 3665 405 8832 1543 1545 1544 50615 6775 834 864 2217 PMC10242999__F3 Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer 3717 1499 3845 7018 5879 5728 1950 7124 2152 2475 406979 407050 407051 406900 PMC10243463__F1 BMP4 signaling in trophoblast emergence from pluripotency 331 10454 652 657 130399 659 92 93 7048 PMC10309513__F2 Triggering receptor expressed on myeloid cells 2–apolipoprotein E signaling pathway in diseases 945 4023 8530 558 928 1435 6696 3687 348 4088 6299 4205 9935 54209 64581 10457 2171 3958 968 581 PMC10310354__F2 Function of Akkermansia muciniphila in type 2 diabetes and related diseases 9965 123 7350 348 PMC10310766__F2 Canonical pathway of p53 that regulates ferroptosis 5820 81894 2232 56301 23657 27165 1994 6303 246 27035 1803 401253 2879 875 PMC10311035__F3 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders 7248 7249 64223 1499 324 PMC10311566__F1 Recent progress of peptide regulators for the Wnt/Beta-catenin signaling pathway 4041 4040 55366 8549 59352 5741 324 1499 2922 4088 4089 PMC10353343__F4 Gene expression changes for genes in the Toll-like receptor 4 (TLR4) Signaling Pathway 3663 4615 929 3654 4118 23118 3929 695 7189 51295 2002 257397 6722 7412 3569 PMC10372646__F1 Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms 1950 6469 3479 2932 5728 5163 PMC10374588__F2 Pathways controlling pyroptosis, apoptosis, ferroptosis, and cuproptosis 114548 147945 22861 9447 7099 2182 10162 84883 30061 79792 7037 8648 8717 7186 8737 23118 2230 11019 1737 2242 8772 1317 637 581 540 PMC10374640__F5 Pharmacological mechanism of Beta-elemene in the treatment of esophageal cancer revealed by network pharmacology and experimental verification 7157 7422 5243 581 595 842 1027 3586 4790 5728 3569 4830 5743 596 999 1956 11200 1499 4318 5111 5925 598 332 1000 1026 2475 5328 6774 3091 4610 5052 7124 7431 331 PMC10374777__F2 Molecular mechanism of ferulic acid and its derivatives in tumor progression 2475 7157 595 6778 1017 1019 1021 3717 581 5111 PMC10375449__F8 Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis 6774 6520 2879 23657 PMC10376197__F2 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation 468 7226 54822 PMC10376197__F4 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation 7226 10395 59341 6714 54822 PMC10377020__F2 ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review 7523 7189 23118 6714 4286 10326 126014 4772 245972 81501 4318 100187907 1513 4094 9817 4773 PMC10377067__F7 Metabolic Profiles Point Out Metabolic Pathways Pivotal in Two Glioblastoma (GBM) Cell Lines, U251 and U-87MG 2539 355 35 34 2744 PMC10377123__F3 Pharmacological Potential of Betulin as a Multitarget Compound 196 405 9817 4094 2730 2729 PMC10377333__F1 Indoleamine 2,3-Dioxygenase (IDO) Activity: A Perspective Biomarker for Laboratory Determination in Tumor Immunotherapy 169355 8564 8942 196 23475 PMC10377916__F2 Revisiting Estrogen for the Treatment of Endocrine-Resistant Breast Cancer: Novel Therapeutic Approaches 6714 7494 581 3162 22926 355 8772 836 7124 6774 841 PMC10378139__F2 Ferroptosis in Cancer Progression 2181 8205 4513 2069 1950 PMC10380440__F3 Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis 821 3458 7124 51596 811 1508 174 6892 920 PMC10380571__F2 Vascular Ageing: Mechanisms, Risk Factors, and Treatment Strategies 165918 84126 472 1017 545 1019 1021 PMC10380929__F3 PINNet: a deep neural network with pathway prior knowledge for Alzheimer's disease 3133 9453 3030 57030 3109 1644 808 5793 784 314 4129 224 120892 3122 1577 1491 2806 10993 8526 6655 92935 5447 23236 3709 7057 4318 2258 783 5331 2934 5562 6850 5290 5027 2693 7939 3606 4067 2316 958 6714 208 284 1906 5467 952 6622 5781 3611 8837 5530 19 581 5970 7097 2778 5580 5566 5604 64127 3551 335 3845 3952 998 5579 3099 5213 3101 472 369 10347 1017 3707 5894 3710 3082 2263 5341 2535 6934 4790 604 351 4088 3815 182 387 5532 5581 7157 4602 54205 5211 25 5914 54115 2043 3265 2033 4609 488 100188776 4775 3728 5291 28514 5048 7042 100 1392 3066 6608 659 476 4780 83439 301 6119 8013 90 2624 1191 6932 4191 3105 3112 3117 PMC10380946__F3 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer 8717 7186 637 8772 355 317 134 581 572 28 19 331 1956 2475 PMC10380946__F5 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer 8772 355 317 581 572 5728 PMC10383966__F1 Pellino Proteins in Viral Immunity and Pathogenesis 3661 3665 29110 4615 2002 3654 51135 10454 257397 23118 7189 3556 79792 PMC10384322__F2 Free Radical and Viral Infection: A Review from the Perspective of Ferroptosis 920 7099 7018 6098 4025 2879 PMC10384765__F6 Exploring the Molecular Basis of Vesicular Stomatitis Virus Pathogenesis in Swine: Insights from Expression Profiling of Primary Macrophages Infected with M51R Mutant Virus 56832 3458 3440 3441 3451 196 9021 6773 3455 10379 3661 10475 7726 3660 6737 7706 2353 PMC10387486__F4 Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets 387 55727 999 9780 25777 23353 4090 4086 3611 4089 4087 4088 7040 PMC10388552__F6 Aberrations in ion channels interacting with lipid metabolism and epithelial–mesenchymal transition in esophageal squamous cell carcinoma 5154 649024 5008 3976 1956 3977 3643 PMC10390051__F3 Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections 2670 6285 2668 7113 59272 55364 PMC10472888__F3 GPX4 in cell death, autophagy, and disease 23657 2879 2729 2937 PMC10473100__F1 Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities 6772 6773 8737 11035 7124 197259 8717 8772 841 54822 4284 7099 4615 7098 PMC10473156__F3 DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease 7518 3981 1763 9156 641 5888 4361 10111 545 PMC10474047__F8 Neurod1/4-Ntrk3-Src pathway regulates gonadotrope cell motility during gonadotrope differentiation 80725 5770 5781 5782 4538 4535 1600 1445 4916 5783 4760 7791 PMC10474074__F2 Kennedy pathway and Lands cycle in ferroptosis 4018 5183 10162 2879 2182 100379198 907 PMC10474093__F9 Working model 6361 22926 1233 6367 8205 PMC10474116__F3 Pathways of mitochondrial quality control 4899 22809 468 10730 8192 2021 139341 664 PMC10474200__F4 Interconnectivity between prioritized high confidence transcription factors 3485 26147 6773 5241 2146 5970 3659 58480 3661 330 7852 1521 2580 7010 9927 5721 133 6775 7124 65989 558 4282 6188 5617 397 3976 PMC10474200__F5 Prolactin signaling pathway 7006 100124696 4752 5879 387 6010 9111 8651 3717 6772 10682 1442 126669 847 2885 3265 5605 PMC10474437__F2 Differentially expressed non-coding RNAs and their regulatory networks in liver cancer 3082 693195 7039 2885 339201 4086 4090 4088 4087 1869 693210 1499 324 27122 1019 1021 84657 693211 7157 3169 6774 311 5728 728655 6714 1950 PMC10474666__F4 FBXW7 in breast cancer: mechanism of action and therapeutic potential 55294 23462 5163 2475 7124 5970 7465 PMC10520679__F1 Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets 6714 382 5338 1956 11031 5873 5874 5872 11021 100170220 406 PMC10520786__F2 Nrf2-mediated therapeutic effects of dietary flavones in different diseases 2022 8452 9817 23411 2534 PMC10520974__F3 Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications 3661 57506 2932 152742 29110 283131 55586 2879 2936 PMC10520974__F7 Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications 920 8205 7046 7048 940 952 1436 PMC10523190__F1 Progress in the research of cuproptosis and possible targets for cancer therapy 538 540 4520 1743 2230 1737 5160 1738 95 PMC10525124__F2 Oxidative Stress in Liver Pathophysiology and Disease 50507 27035 50506 53905 79400 9817 847 PMC10526115__F3 Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented? 627 4803 23479 8031 468 22926 10000 207 2932 208 8660 3667 3605 PMC10526140__F4 Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology 5728 4609 675 672 275 545 PMC10527328__F1 Exploring the Molecular Landscape of Myelofibrosis, with a Focus on Ras and Mitogen-Activated Protein (MAP) Kinase Signaling 867 2885 4763 673 4352 811 PMC10530696__F1 Deciphering the Enigmatic Influence: Non-Coding RNAs Orchestrating Wnt/Beta-Catenin Signaling Pathway in Tumor Progression 101669762 154822 693166 1499 6659 79854 324 729177 693223 6667 100652772 PMC10531065__F8 Antitumor Effect of the DNA Polymerase Alpha Inhibitor ST1926 in Glioblastoma: A Proteomics Approach 4522 2194 7534 283571 6624 3301 11335 2821 396 293 191 7913 26227 10525 10226 5315 11240 301 5037 6117 6513 8663 PMC10531073__F3 Fluconazole-Induced Protein Changes in Osteogenic and Immune Metabolic Pathways of Dental Pulp Mesenchymal Stem Cells of Osteopetrosis Patients 492 91663 4151 488 1371 441531 308 5836 301 4478 309 5925 10890 PMC10532419__F3 LOXL2 in Cancer: A Two-Decade Perspective 4017 23081 6935 9839 6667 2353 54764 54765 51162 PMC10532491__F3 Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer 1950 6774 1956 6772 8205 374 PMC10534927__F3 Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives 1431 115004 29110 3383 7412 27159 5177 1401 PMC10535870__F9 Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats 2475 581 596 PMC10536053__F3 Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer 286257 7518 3981 5426 641 9156 1763 5893 2067 PMC10536053__F4 Targeting DNA Damage Repair and Immune Checkpoint Proteins for Optimizing the Treatment of Endometrial Cancer 6741 10111 545 7465 983 1017 472 3600 29110 3661 115004 6352 3627 PMC10537991__F4 Quantitative Differences in Rumen Epithelium Proteins in Lambs Fed Wheat, Perennial Wheat, or Perennial Wheat plus Lucerne 197322 27349 54995 84869 7923 109703458 51102 35 36 3033 10449 100034703 3420 201562 9524 PMC10538549__F1 cGAS-STING signaling pathway in intestinal homeostasis and diseases 6573 57864 5167 115004 3428 3553 29110 3661 6778 7297 6773 10379 6774 PMC10538757__F2 STRING analysis of protein–protein interactions 4851 1786 5243 6774 5966 4118 572 9099 18 55696 25949 27339 7157 9716 PMC10539319__F1 Systemic iron sources and metabolism 154214 9843 2056 PMC10539319__F3 Testicular iron metabolism and ferroptosis 1356 7018 154214 8031 2182 2512 2879 23657 10162 1728 23516 PMC10539698__F3 Emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages 170 4513 8205 2475 6774 1234 729230 PMC10539878__F3 Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease 3554 8772 7124 79184 5763 29108 846 57506 9927 114548 79792 PMC10539942__F1 Ferroptosis in effects of anesthetics on multiple organ diseases: A literature review 6774 10162 2182 9817 2539 2879 PMC10539950__F2 Innate immune signalling in response to cytosolic DNA and DNA damage 115004 3661 29110 3627 6352 5971 472 3428 7189 6364 PMC7614756__F6 Effect of NRP1 on the TGFBR2-VE-cadherin pathway in regulating adherens junctions and inflammatory responses 8829 3569 1401 7043 7040 7042 6373 2919 3162 3589 2920 3592 6402 6403 1440 58191 6387 3603 23411 6347 6352 1435 1003 7048 PMC8535854__F2 Metabolic changes allow cancer cells to survive in circulation and promote colonization of distant organs 8205 999 6714 5625 3417 406992 PMC8571027__F4 Arginine methylation negatively regulates the anti-viral response 84166 10419 3428 115004 29110 3661 54496 10196 55170 57506 PMC8651070__F2 Mechanisms Regulating HLA Class-I Antigen Processing Machinery Component Expression in Cancer Cells 3716 6772 3717 115004 3661 3665 29110 7186 7188 3659 4050 7187 4077 PMC8669353__F3 DNA methylation profile of liver of mice conceived by in vitro fertilization 6810 6844 2475 867 1398 47 5728 5163 5140 3991 572 2549 2885 3643 2534 9021 2887 PMC8678298__F1 Renal and Intestinal Urate Physiology 116085 56606 4118 10050 9429 10864 4942 PMC8736280__F1 Vasculopathy in COVID-19 1636 5879 59272 4142 1003 10365 1267 5091 324 1431 2224 5340 1604 966 PMC9010455__F2 Upstream Regulator Analysis, based on “omics” integration using the Ingenuity Pathway Analysis software 558 6890 960 4313 975 4869 5970 4723 1956 3190 1382 9636 6876 2099 367 2475 6774 717 7157 1386 8743 3725 4792 6597 PMC9048811__F2 Epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson’s disease 120892 65018 23410 1786 54790 4899 23369 6622 103611090 PMC9085972__F11 BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance 26000 9531 11021 PMC9099564__F2 Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives 960 648 10215 79923 6657 5764 6678 8404 10763 6010 2475 PMC9143803__F2 New Insights into the Pathogenesis of Giant Cell Arteritis: Mechanisms Involved in Maintaining Vascular Inflammation 7879 920 1524 929 729230 6347 4283 1236 941 942 9308 6363 6362 6366 50943 PMC9160962__F1 Methyl Metabolism and the Clock: An Ancient Story With New Perspectives 2348 115286 10797 441024 123263 2356 160428 6472 25902 1738 2731 81034 10588 113235 6573 6470 4522 1719 4524 7298 10841 6611 6723 51074 58478 55256 4552 4548 2618 55349 471 10840 635 23743 501 4143 4144 27430 191 100188776 23382 1491 262 PMC9329261__F2 Elevated CD4+ T Cell Glucose Metabolism in HIV+ Women with Diabetes Mellitus 3101 5164 5160 3417 130752 PMC9343399__F7 Key role of aminoacylase-1 in myocardial fibrosis and the regulatory effect of 20(S)-ginsenoside Rg3 in heart failure 7045 4088 4312 PMC9371363__F2 Negative and positive regulators of IL-4 and IL-13 signaling: 3566 6778 3718 383 54625 3716 3667 8651 9021 142 3597 7297 3717 6774 84818 7189 PMC9489610__F3 Evidence for activation of apoptosis in ALS 596 4170 572 637 203228 2521 666 581 842 4149 29110 8737 836 PMC9489610__F5 Necroptotic signaling mechanisms and outcomes in ALS 6647 10133 29110 8737 197259 11035 8772 841 PMC9489683__F3 Treg suppression of conventional T cells 324 8829 10875 201633 3902 941 942 3248 940 355 196 6774 PMC9492833__F2 Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy 53407 662 55850 9554 55014 65082 22863 9842 6811 10282 8417 9482 8673 6845 10228 8674 8411 8675 11311 6844 9341 6809 127833 PMC9561407__F3 Iron metabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns 326343 23657 729082 401253 2553 102465513 875 150696 145249 100129387 2879 2182 10162 6520 10146 PMC9576167__F1 Platelets and tyrosine kinase inhibitors: clinical features, mechanisms of action, and effects on physiology 6850 4067 2534 4512 27040 5336 695 7006 100124696 PMC9587158__F1 Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD 11075 55272 10146 PMC9620650__F2 Role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights 9350 468 2475 9776 60673 8408 7852 23411 10533 9474 664 PMC9623116__F4 Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential 84876 6786 613 6850 695 29760 637 581 90550 PMC9623986__F3 Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data 5893 84515 23604 1612 1613 1017 983 890 7161 9184 9134 2033 1263 83737 5347 1111 25898 5300 79728 699 675 2261 3845 3265 369 673 11186 5604 5605 5594 5595 1149 9252 51741 10277 6942 51654 1020 1432 PMC9626535__F10 MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome 581 596 2879 PMC9629834__SF4_2 Protein network and Netrin-DCC pathway analysis 5813 6529 2775 4773 8831 6812 6792 65061 9423 1630 5747 1759 6714 6616 8633 4690 5063 5781 998 387 5879 3983 9475 817 816 2890 5335 815 818 4905 7102 163 5582 1173 5579 161 1175 160 PMC9634729__F1 Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma 6741 4436 4437 7508 7516 672 PMC9635594__F1 Schematic diagram showing the mucins role in cancer stemness and chemoresistance 4582 79923 6657 7852 1956 5243 2309 4585 581 596 4040 1499 8549 960 4586 56667 94025 3717 6774 85453 4005 PMC9635594__F3 Schematic diagram showing the role of mucins in cancer metabolism 6513 4582 5230 2023 3099 3939 5208 55276 5315 57103 672 5163 56667 94025 PMC9636677__F6 Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC 3146 581 596 983 891 PMC9637147__F1 Molecular mechanisms of ferroptosis 23657 6520 2936 27165 1723 2879 4967 19 27035 1803 3156 123 4891 7037 8031 10162 3162 2643 55640 55652 113235 5447 PMC9640682__F4 MiR-27a as a diagnostic biomarker and potential therapeutic target in systemic sclerosis 6774 2735 1499 3479 3082 2885 5163 7189 4087 4088 4089 3611 1000 4322 PMC9641500__F2 Lysophospholipid Mediators in Health and Disease 5091 4023 4018 4099 124976 388931 4827 4026 55937 8877 56848 PMC9643504__F2 Hippo signalling pathway and its implications in human health and diseases 4485 55841 23286 80014 60485 9113 26524 7004 8463 7003 7005 PMC9643504__F3 Hippo signalling pathway and its implications in human health and diseases 154796 4771 6478 51701 23513 999 650 55243 PMC9645326__F2 Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections 5476 213 59272 PMC9645596__F1 TGFB: Signaling Blockade for Cancer Immunotherapy 6010 7939 4092 57154 9618 7189 7375 9958 8237 2885 4088 4087 4089 64750 7046 7048 PMC9646457__F7 Myeloid checkpoints for cancer immunotherapy 10859 567 6714 10288 348 11006 383 PMC9647118__F2 Homologous recombination 9156 4827 79728 675 580 5888 PMC9647168__F1 Modification of phosphoinositides by the Shigella effector IpgD during host cell infection 7074 3383 1956 10043 PMC9649847__F1 Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury 7099 999 9575 114609 4615 PMC9650365__F1 Crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease 9474 64422 581 2475 84971 8408 9140 PMC9653766__F1 Predictive and Prognostic Role of RAS–RAF–MEK–ERK Pathway Alterations in Breast Cancer: Revision of the Literature and Comparison with the Analysis of Cancer Genomic Datasets 22821 5922 9462 8437 64926 5037 6196 6197 6195 8061 283455 8844 10256 4609 6654 3845 3265 5781 4133 5604 5594 2353 2113 3725 2114 4193 2002 10235 25780 115727 10125 5924 5923 9693 2889 9986 23463 10253 81848 10251 10252 2077 8682 5300 1844 1843 1845 1847 1846 1848 23513 22808 5364 5728 PMC9654076__F1 Molecular Targeting of the Most Functionally Complex Gene in Precision Oncology: p53 4117 472 545 4193 581 1019 1021 PMC9654300__F2 Aberrant B Cell Signaling in Autoimmune Diseases 26191 613 7189 1445 4067 8915 84433 10892 973 974 6850 640 930 55024 695 5728 4609 2002 933 971 2475 PMC9655478__F10 L-Citrulline Supplementation Restrains Ferritinophagy-Mediated Ferroptosis to Alleviate Iron Overload-Induced Thymus Oxidative Damage and Immune Dysfunction 8031 3553 4280 2879 6647 PMC9656396__F3 Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy 7248 7249 6009 6733 5728 6446 2194 55902 47 2932 55294 65220 5163 PMC9656902__F4 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways 6659 84793 10419 6774 102723932 619501 285987 1788 1786 1789 23705 PMC9656902__F5 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways 400500 79753 3099 5209 2735 6608 5727 2619 6657 PMC9657218__F4 Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress 472 7518 5893 142 10721 5888 9156 1763 PMC9661388__F6 Basal diet composition contributes to differential performance, intestinal health, and immunological responses to a microalgae-based feed ingredient in broiler chickens 84890 31 178 2582 3420 51422 55276 4117 660 51703 51083 54677 56894 2182 PMC9661392__F8 Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway 55273 6339 999 1000 581 595 PMC9664671__F1 HOXA9 in solid tumors: mechanistic insights and therapeutic potential 9140 8408 9776 2353 3725 3099 5163 3205 3667 1499 1536 860 6657 596 2475 PMC9665039__F3 Signalling by TNFR1 and overview of the three characterized cell death checkpoints in the TNFR1 pathway 10010 81858 8737 8717 8772 7124 79792 23118 11035 197259 PMC9667393__F2 Increased Pi availability on cellular signaling 10818 1958 6722 4513 2303 7422 PMC9669386__F1 Ferroptosis in lymphoma: Emerging mechanisms and a novel therapeutic approach 468 2936 2937 6520 23657 2879 6772 55240 8031 10162 4015 6319 2181 PMC9671555__F4 Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease 1636 59272 340024 PMC9672399__F5 Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins 6423 1315 70 2194 2159 203068 3908 5919 6422 47 1410 7170 1675 7474 5176 1404 8425 338 720 721 4869 26585 351 710 3190 1435 3949 567 3958 1519 3026 5791 5649 3569 718 4016 1464 6678 1462 348 4237 7130 4323 22795 347 4884 5806 84624 3487 1191 5549 27286 3240 25903 1278 4854 84171 1893 3698 2199 4052 84695 PMC9675801__F1 SPATA2 at the level of TNF-RSC 9825 1540 81858 7124 7186 8717 8737 10454 23118 11035 197259 8772 841 717 PMC9676924__F3 CD160 receptor in CLL: Current state and future avenues 637 581 5728 5163 6850 3717 6774 PMC9678516__F9 Exploring the mechanism of Tengli Kangliu Decoction in the prevention and treatment of colorectal cancer precancerous based on network pharmacology 7124 5327 6010 3659 2152 4353 10855 1519 1576 11200 860 5467 1401 3099 5328 3481 6347 598 367 5579 31 2147 338 6401 1017 581 1909 5241 596 1147 3725 54205 4609 890 1870 2353 1869 5770 1956 3551 5970 4843 2908 5468 4306 7157 PMC9679015__F2 Polymerase D-interacting protein family and their emerging roles in diseases 26073 387 1894 50507 7442 10845 3091 51601 595 1000 PMC9679292__F2 New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke 100 875 2744 1491 7296 2182 2937 2241 2936 10162 2879 PMC9679292__F3 New insights in ferroptosis: Potential therapeutic targets for the treatment of ischemic stroke 100 2182 10162 2879 468 55240 23657 7018 1758 4094 PMC9680067__F4 Teleost NOD-like receptors and their downstream signaling pathways: A brief review 920 7189 197358 114548 2475 84166 6774 3717 7422 PMC9682072__F3 Viral tropism for the testis and sexual transmission 7099 7098 7097 7100 10333 4615 3661 8651 3627 8027 2621 9636 4599 115004 PMC9682695__F1 Early postnatal alterations in follicular stress response and survival in a mouse model of Classic Galactosemia 2584 468 2592 PMC9684507__F6 rs28714259 risk (A) allele dysregulates genes following dexamethasone/doxorubicin combination treatment and contributes to an attenuated hypertrophy signaling 6010 1730 10846 1978 3480 9759 201164 PMC9685611__F2 Ovarian cancer stem cells: Critical roles in anti-tumor immunity 4512 999 960 4615 1363 1493 100506311 404201 PMC9685675__F6 Roux-en-Y gastric bypass-induced perturbative changes in microbial communities and metabolic pathways in rats 151056 3931 2531 123099 427 56624 10715 79603 PMC9686736__F4 Targeting Mitochondrial Metabolism to Reverse Radioresistance: An Alternative to Glucose Metabolism 331 581 472 6741 718 6774 PMC9686795__F1 Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer’s Disease: Therapeutic Implications and Future Perspectives 120892 65018 51024 4077 8887 8408 60673 9776 22863 55626 PMC9687113__F2 DNA Damage and Repair in Idiopathic Pulmonary Fibrosis 4595 5111 3978 5423 3980 6741 7508 7507 4436 2956 5395 9156 PMC9687595__F2 Wound Healing versus Metastasis: Role of Oxidative Stress 9817 1728 847 50507 5163 7124 3553 PMC9688160__F1 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders 6714 9113 26524 7004 8463 7003 7005 6010 558 4485 9448 8491 11183 11184 5871 60485 PMC9691389__F6 Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis 7012 3949 2066 382 273 160 60 1601 3310 161 868 163 22905 9372 4087 30844 11337 11345 5867 2204 7097 9146 2212 2213 2215 29082 51160 7059 1200 3111 3105 9476 968 138050 54 4891 PMC9692260__F1 Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical 7412 3383 114548 317 581 PMC9693004__F3 Hematotoxic Effect of Respiratory Exposure to PHMG-p and Its Integrated Genetic Analysis 4313 6010 393 3569 7184 57817 51649 22926 23155 5925 8553 948 7297 114294 3458 4170 PMC9693225__F3 Shared Proteome of the Apomictic Fern Dryopteris affinis ssp. affinis and Its Sexual Relative Dryopteris oreades 55276 2023 6651 1973 9610 56961 4485 847 PMC9695095__F2 The NLRP3 inflammasome in chronic inflammation in asthma and chronic obstructive pulmonary disease 7099 114548 8989 7442 59341 8544 834 7226 196 4586 23411 79792 103 PMC9695228__F11 Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core 6608 156 51684 55582 2932 2619 50937 91653 PMC9697637__F2 Marine Natural Products from the Russian Pacific as Sources of Drugs for Neurodegenerative Diseases 1020 2932 351 PMC9701458__F4 Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy 3791 5950 208 4069 1956 729230 629 3265 207 5599 7010 4317 4318 2321 7276 8639 7454 4314 2811 2099 1268 5594 1636 6093 7421 1576 2346 3320 6850 387 6524 102 3690 4790 8877 5328 4313 1230 2066 3156 5972 3091 598 1544 5321 2260 5294 4846 213 2944 3312 154 5894 3934 998 1020 5604 3643 596 3676 5159 6774 7046 1234 4843 7099 6401 1559 3251 3558 340061 3717 5879 2475 116085 353 841 8766 5468 5578 4325 834 6648 2147 3308 6890 5054 836 1803 5747 2263 3688 5295 5580 1080 695 5241 7535 5478 43 4282 2159 4311 5742 6714 6352 6548 153 5743 673 2902 PMC9703913__F2 Cofilin Acts as a Booster for Progression of Malignant Tumors Represented by Glioma 6010 407021 407026 998 5058 6093 9475 7046 7048 208 9948 7291 11326 PMC9705963__F1 Ferroptosis in osteosarcoma: A promising future 23657 9682 6774 2936 6520 2879 7018 55240 5447 10162 4015 PMC9706722__F3 Genomic characterization of intracranial teratomas using whole genome sequencing 2475 4609 64840 7004 139285 10608 5728 5290 5518 6794 4613 253260 4084 4149 51107 675 23269 1869 8216 83439 5664 3714 6422 6423 7046 9611 4763 7157 2322 2260 3845 2196 369 2261 4914 6197 11200 472 5784 8642 54798 PMC9709426__F2 Targeting ferroptosis, the achilles’ heel of breast cancer: A review 4921 3131 51684 2182 2879 2181 23657 22943 6774 6925 2264 PMC9746897__F2 Pyroptosis: A new insight of non-small-cell lung cancer treatment 79792 114548 3458 7124 55876 3001 3146 56169 841 1687 836 284110 3002 PMC10131518__F2 Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma 1649 83737 6347 960 596 7422 7040 8837 356 6774 5783 3725 8797 PMC10137169__F1 One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes 27232 4524 151842 4548 635 84890 875 1491 191 10400 5091 PMC10138370__F6 GCN2/eIF2A/ATF4 Pathway in the Liver and Induction of FGF21 in Young Goats Fed a Protein- and/or Phosphorus-Reduced Diet 26227 7018 29968 26136 5723 6470 6472 PMC10138803__F7 MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells 929 7099 4615 51135 3654 7189 5970 4548 3569 3553 3552 3716 3717 6774 PMC10139073__F3 Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone 1901 1903 4513 9294 2932 1499 8877 PMC10141502__F1 Nutrigenomic profiling of reduced specification diets and phytogenic inclusion effects on critical toll-like receptor signaling, mitogen-activated protein kinase-apoptosis, and PI3K-Akt-mTOR gene components along the broiler gut 9516 3569 4049 7099 355 4615 3265 7249 7189 1147 7098 3661 PMC10143579__F1 Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD 23475 8564 8942 130013 PMC10148646__F1 Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection 619501 1499 2002 6722 2950 50507 1789 PMC10149902__F12 Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis 284207 4280 348 PMC10149936__F14 Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth 10298 6714 6010 5879 PMC10149994__F1 Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses 57506 3661 10379 6772 6773 57762 PMC10150004__F1 Infection routes, invasion mechanisms, and drug inhibition pathways of human coronaviruses on the nervous system 6347 6351 3627 7054 4283 59272 1803 7113 PMC10151763__F2 Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy 650 9365 860 1499 7477 PMC10151830__F7 Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy 2597 2194 31 1674 34 3030 PMC10153444__F2 Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders 10371 2534 1020 PMC10237023__F2 Intratumour microbiome of pancreatic cancer 2919 2920 3579 6850 64170 90865 7099 7097 834 114548 100653366 975 PMC10239166__F1 Transcriptional regulation on effector T cells in the pathogenesis of psoriasis 3717 3570 920 50943 3559 3566 PMC10239578__F4 Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma 2254 2256 5649 1280 4803 5156 3696 8516 2885 5728 2475 572 4193 PMC10242157__F7 Versatile role of Serpina3c in physiological and pathological processes: a review of recent studies 1499 2308 7099 3164 2023 PMC10243716__F2 Ferroptosis as a vulnerability in cancer 2879 60481 1723 2643 999 1956 4771 7428 3417 7037 2182 50507 29923 PMC10243851__F1 Clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis 7248 7249 6009 960 9113 26524 1499 3661 PMC10244677__F1 Integrated high-throughput analysis identifies super enhancers in metastatic castration-resistant prostate cancer 367 2289 405 10460 23476 613 89796 PMC10260623__F1 Schematic of the clock pathway 406 4862 9575 1628 9572 7018 PMC10302997__F1 Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention 7405 9140 5266 10533 9474 9776 83734 2475 8408 55054 64422 PMC10307880__F2 Viral-mimicry response induced by DNMTis 6780 57506 3661 3665 29110 7098 26136 3466 PMC10308077__F2 Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective 26291 27329 7873 64838 10457 90 4023 152831 1234 2842 960 23411 7350 4088 10682 5468 PMC10308135__F4 Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis 4015 5159 6696 PMC10308667__F1 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis 2932 324 1499 4920 5879 387 PMC10308769__F1 First reported double drug–drug interaction in a cancer renal patient under everolimus treatment: therapeutic drug monitoring and review of literature 3667 5728 6009 7249 7248 5163 2475 64798 8408 64223 253260 PMC10309183__F4 Ether lipids and a peroxisomal riddle in sperm 8443 84803 137964 150763 84188 8540 25979 PMC10309559__F2 IFNB expression: focusing on the role of its promoter and transcription regulators 8195 7189 4615 57506 108348016 29110 115004 6773 6772 PMC10311035__F2 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders 22943 324 50964 1499 4086 4090 4089 4771 4485 9113 26524 28514 54567 10683 6608 51684 999 6422 100188776 PMC10311176__F3 Transcriptome analysis of CD4+ T cells from HIV-infected individuals receiving ART with LLV revealed novel transcription factors regulating HIV-1 promoter activity 4792 7128 3164 3726 1959 1958 3576 6351 7124 3553 5743 7099 5336 6850 2354 4929 115650 3383 958 10673 3725 5187 2353 4783 9839 7071 467 8013 10221 4605 4318 64651 9314 6659 1390 2920 3569 604 9586 1326 602 4323 3976 3205 1052 3087 7088 1879 53335 6925 9935 23316 30009 3394 1488 1050 6660 5079 84969 3221 3662 10644 26040 4778 8638 9242 22797 27287 4286 PMC10311254__F1 Unlocking the power of precision medicine for pediatric low-grade gliomas: molecular characterization for targeted therapies with enhanced safety and efficacy 5163 5728 2475 7248 3845 673 4763 PMC10311505__F3 YAP at the progression of inflammation 7189 4485 3654 23586 7187 3661 57506 29110 115004 PMC10311568__F2 Research progress of sophoridine’s pharmacological activities and its molecular mechanism: an updated review 1017 2104 1499 5728 PMC10311615__F11 18Beta-glycyrrhetinic acid inhibits proliferation of gastric cancer cells through regulating the miR-345-5p/TGM2 signaling pathway 2475 9776 7052 8878 10533 4077 PMC10311893__F5 MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study 4801 3953 8809 57758 2690 2099 9612 6135 6890 650 7157 6934 7481 2309 8445 1908 PMC10313199__F3 Advances in epigenetic modifications of autophagic process in pulmonary hypertension 3065 3066 8841 10014 10013 51564 23411 79885 2475 2308 9474 8678 10533 PMC10357943__F3 Shining a light on the dark proteome: Non‐canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology 5163 10000 57646 55294 57650 1956 6774 6714 401397 PMC10372241__F1 New insights into regulatory cell death and acute pancreatitis 355 8772 637 4170 581 331 317 PMC10373067__F2 Bispecific antibody targeting TGFB and PD-L1 for synergistic cancer immunotherapy 7939 5045 4087 4088 7049 4089 7048 7046 PMC10374481__F7 HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations 330 637 581 317 331 1956 PMC10374743__F2 Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells 5209 3099 2597 3939 PMC10375050__F2 Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease 10392 64127 7189 3661 PMC10375783__F2 Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy 472 23657 2879 115004 2182 10162 5447 PMC10376127__F2 New Insights on the Uptake and Trafficking of Coenzyme Q 57107 23590 27235 51805 84274 2230 51004 2232 112812 10229 218 3652 140805 51117 57017 56997 79934 93058 80219 PMC10376170__F2 Targeting Triple-Negative Breast Cancer by the Phytopolyphenol Carnosol: ROS-Dependent Mechanisms 22926 6774 2475 468 581 PMC10376197__F3 TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation 7222 4773 8989 7442 581 7226 PMC10376369__F5 Alzheimer’s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress 581 572 2932 627 1889 PMC10376369__F7 Alzheimer’s Disease and Green Tea: Epigallocatechin-3-Gallate as a Modulator of Inflammation and Oxidative Stress 4170 581 2932 5728 PMC10376673__F1 Breaking Bad: Inflammasome Activation by Respiratory Viruses 79792 114548 115004 PMC10376943__F4 FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway 2246 2475 1950 1956 PMC10377024__F3 Landscape of Genetic Mutations in Appendiceal Cancers 3265 4893 7039 1950 3082 1956 2064 3815 2322 2885 5336 2767 3845 5900 673 6010 4609 PMC10377024__F5 Landscape of Genetic Mutations in Appendiceal Cancers 7157 1026 472 545 7046 7048 PMC10377491__F1 Landscape of Small Leucine-Rich Proteoglycan Impact on Cancer Pathogenesis with a Focus on Biglycan and Lumican 6774 3717 633 2191 3146 101928931 55294 PMC10377498__F5 Mitophagy: A Bridge Linking HMGB1 and Parkinson’s Disease Using Adult Zebrafish as a Model Organism 5071 7099 51024 3146 PMC10378150__F1 STAT3 deficiency prevents GVHD in target organs while preserving GVL activity in lymphohematopoietic tissues 6774 920 4609 PMC10378789__F2 Revisiting the Role of Autophagy in Cardiac Differentiation: A Comprehensive Review of Interplay with Other Signaling Pathways 5163 9776 2475 8408 596 22863 23192 10533 64422 729 9140 83734 9474 55054 PMC10379376__F2 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells 8932 1019 1021 595 894 6929 6657 79923 122060 10766 9802 10637 7044 4838 PMC10379376__F5 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells 1789 55870 6929 6657 207 2146 23512 79923 26524 7465 PMC10379484__F2 Endothelin-1 in Health and Disease 1906 7450 4827 975 3920 PMC10379601__F5 Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis 1595 50814 51478 1717 10682 1718 PMC10379778__F1 ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin 5170 207 7249 6194 5605 6654 6464 1616 2353 1051 3725 673 6885 331 4214 7189 4091 4087 1386 5054 998 5058 387 7528 1387 6667 6093 5879 983 50855 4616 324 6498 51343 PMC10379778__F2 ARHGAP1 in Rho GTPase Inactivation during Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin 1001 1000 999 6714 28514 1499 3728 9223 9863 7414 2035 2241 324 998 5728 8826 5879 51176 6249 387 PMC10380201__F7 Small-Extracellular-Vesicle-Derived miRNA Profile Identifies miR-483-3p and miR-326 as Regulators in the Pathogenesis of Antiphospholipid Syndrome (APS) 7412 3383 2475 5728 2152 941 7018 PMC10380468__F2 Investigation of the Effects of Metallic Nanoparticles on Fertility Outcomes and Endocrine Modification of the Hypothalamic-Pituitary-Gonadal Axis 1839 2798 1956 1958 3972 2488 PMC10380532__F2 mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy 64223 2475 64798 9675 253260 PMC10380735__F1 Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease, the Consequence of Neural Cell Death 317 8717 355 8772 PMC10380946__F2 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer 8772 355 317 581 572 3014 PMC10380946__F6 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer 317 581 572 PMC10382028__F1 Plant-derived extracts and metabolic modulation in leukemia: a promising approach to overcome treatment resistance 6387 7852 2475 5111 3725 5214 226 2597 5315 PMC10382180__F3 Immunity by tryptophan microbial metabolites 196 405 57491 1544 1545 100379198 PMC10384366__F11 Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells 999 1499 6929 6662 9314 79923 PMC10384750__F6 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer 2475 3667 6009 5163 7248 7249 5728 PMC10389832__F1 CGAS-STING in Age-Related Diseases from Mechanisms to Therapies 115004 29110 3661 PMC10389832__F4 CGAS-STING in Age-Related Diseases from Mechanisms to Therapies 11277 5167 80198 3661 142 6774 3717 PMC10390225__F2 Mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis 3569 4282 2204 718 929 PMC10390316__F1 Cellular mechanisms of fibrin (ogen): insight from neurodegenerative diseases 3383 3569 6347 3627 1956 387 90 PMC10472646__F1 Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application 1493 8030 50943 100187761 7874 1786 5243 PMC10473115__F2 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease 54209 1611 6850 5335 PMC10473115__F3 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease 54209 348 5336 PMC10473115__F4 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease 54209 5336 1611 6850 PMC10473154__F1 Understanding the Involvement of microRNAs in Mitochondrial Dysfunction and Their Role as Potential Biomarkers and Therapeutic Targets in Parkinson’s Disease 4899 7019 6622 65018 120892 4976 9927 55669 PMC10474042__F2 Calcium signaling in efferocytosis 10461 51185 84876 6786 90550 PMC10474116__F4 Apoptotic signaling pathways 8772 637 581 317 638 331 PMC10474147__F2 Necrosis and apoptosis: morphological features and signaling pathways 8772 8717 843 841 637 836 840 581 842 PMC10474740__F2 Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization 3490 2885 79812 4087 3479 2308 6598 3667 3480 22918 6714 999 1003 1839 PMC10474740__F3 Angiogenesis modulated by CD93 and its natural ligands IGFBP7 and MMRN2: a new target to facilitate solid tumor therapy by vasculature normalization 3490 22918 79812 1398 998 5879 387 6714 5062 999 5878 PMC10483736__F1 Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA) 7015 1200 25913 100134934 79991 80169 PMC10508215__F1 AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3B,17Beta-Diol 1583 3283 1646 1586 412 8644 1645 PMC10518439__F2 Pyroptosis and inflammasomes in cancer and inflammation 79792 3146 56169 1687 3002 3001 55876 PMC10519146__F10 Intracellular innate immune response to avian influenza 3661 3665 7189 24138 57506 51284 4615 3458 7098 7187 29110 8638 10581 91543 PMC10523725__F7 Gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis 23657 6520 2879 PMC10525260__F3 Multi-Faceted Role of Cancer-Associated Adipocytes in Colorectal Cancer 7124 389421 63976 7350 89780 6774 7480 4312 2167 2919 2920 5140 5352 4035 PMC10525531__F7 High Hepcidin Levels Promote Abnormal Iron Metabolism and Ferroptosis in Chronic Atrophic Gastritis 6774 3717 2879 PMC10525645__F1 Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development 538 540 475 6647 9973 5250 10063 1356 150684 PMC10525998__F10 Transcriptomic Analysis of Light-Induced Genes in Nasonia vitripennis: Possible Implications for Circadian Light Entrainment Pathways 9575 1408 4862 PMC10526161__F1 Integrated Multi-Omics Profiling of Young Breast Cancer Patients Reveals a Correlation between Galactose Metabolism Pathway and Poor Disease-Free Survival 5290 7157 999 PMC10526485__F2 Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases 286097 10367 55013 221154 90550 PMC10526530__F2 What General Neurologists Should Know about Autoinflammatory Syndromes? 4598 9051 828 114548 834 3606 64127 3586 90268 11277 6611 115004 PMC10526805__F2 Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes 375 382 5728 153090 55353 4734 1956 4134 8826 PMC10526805__F3 Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes 5297 8826 5163 PMC10526871__F3 Nuclear Estrogen Receptors in Prostate Cancer: From Genes to Function 1950 3479 6714 3725 PMC10526873__F1 G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology 7124 6714 1950 1839 1956 PMC10528301__F3 An Overview of CD133 as a Functional Unit of Prognosis and Treatment Resistance in Glioblastoma 11140 595 7248 4193 7249 1978 1977 5894 2810 596 4846 5743 PMC10528430__F1 Microglial responses in Alzheimer’s Disease 7124 7099 1436 945 1524 1471 53829 64805 338773 834 90865 348 1378 54209 3945 5315 6850 6772 6774 5080 478 4704 2475 718 7097 3687 8530 4023 972 PMC10528641__F2 Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes 4485 9113 26524 60485 5728 2475 PMC10529750__F6 Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis 6648 116512 23410 PMC10530385__F1 Tet1 regulates pathways responding to PM2.5-induced oxidative stress 3091 405 196 7039 374 1543 3162 1728 9817 1956 7494 7186 90865 3553 3312 4189 PMC10530558__F2 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells 3099 2821 3939 4613 4609 3845 PMC10530916__F8 Endoplasmic Reticulum Stress-Related Ten-Biomarker Risk Classifier for Survival Evaluation in Epithelial Ovarian Cancer and TRPM2: A Potential Therapeutic Target of Ovarian Cancer 4790 5970 6772 3091 5468 6774 6667 2099 3569 7157 PMC10531041__F2 Stress Response in Autophagy Processes and Aging-Related Diseases 10576 26353 9531 23192 10533 PMC10531058__F1 Lnc-RNAs in the Pathogenesis and Development of Diabetic Retinopathy 100507246 3667 2475 55384 100859930 PMC10531306__F2 Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism—A Favorable Backdoor Mechanism for the GHR Function 2690 3479 3717 6714 PMC10532123__F6 Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells 100653366 79923 5460 6657 145873 55897 4691 3791 5156 2626 9350 22943 3670 1482 6910 8322 70 7139 4624 PMC10532319__F7 Isolinderalactone Induces Apoptosis, Autophagy, Cell Cycle Arrest and MAPK Activation through ROS–Mediated Signaling in Colorectal Cancer Cell Lines 995 890 1017 842 836 PMC10534279__F4 Growth differentiation factor 15 in cancer cachexia (Review) 7046 6774 5443 4852 389400 1392 2638 5979 4296 9518 581 6347 4087 4088 4089 PMC10534805__F9 Lonicera Caerulea Juice Alleviates Alcoholic Liver Disease by Regulating Intestinal Flora and the FXR-FGF15 Signaling Pathway 4280 7038 8213 1581 5465 4583 4585 PMC10535706__F8 Akkermansia muciniphila inhibits tryptophan metabolism via the AhR/Beta-catenin signaling pathway to counter the progression of colorectal cancer 7166 196 1499 3398 PMC10535809__F2 Host and HBV Interactions and Their Potential Impact on Clinical Outcomes 355 6418 920 PMC10536747__F2 Liver and Muscle Transcriptomes Differ in Mid-Lactation Cows Divergent in Feed Efficiency in the Presence or Absence of Supplemental Rumen-Protected Choline 51422 6319 23175 5467 2170 3099 5606 PMC10537413__F4 Unraveling MYC’s Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance 23476 1025 1022 4609 2475 7874 57646 57602 5347 4149 PMC10538627__F1 Research progress on the role of the Wnt signaling pathway in pituitary adenoma 4041 4040 8312 8313 1499 324 1537 4609 998 5879 1386 387 PMC10540075__F8 Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights 8140 120103 130013 8564 8942 160728 6581 23475 93100 23057 64802 349565 65220 203447 10135 84561 952 PMC10540449__F1 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications 10454 331 1386 4090 4086 4093 4089 4091 4092 PMC10540449__F4 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications 4089 4091 4092 4090 4086 4093 4288 6469 324 1499 7374 657 7431 PMC10540768__F2 Unleashing the power of complement activation: unraveling renal damage in human anti-glomerular basement membrane disease 727 716 715 720 717 10747 5648 735 729 718 PMC8485741__F1 Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection 7098 3661 3665 51284 51311 4615 7706 57506 9636 4599 6772 6773 10379 7297 PMC8535854__F1 Metabolic reprogramming orchestrates primary tumor cell invasion and supports PMN priming via exosomes 64422 10533 5209 PMC8604761__F1 Pyroptotic pathway in immune cells 79792 8737 7124 3553 114548 PMC8669714__F1 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics 7124 11035 8737 8717 7185 8772 331 197259 637 317 638 PMC8669714__F3 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics 638 637 8408 9474 9140 10533 60673 9776 331 2475 PMC8692171__F1 PTEN-PI3K-AKT-mTOR pathway and therapeutic targets 5310 5728 7248 7249 6009 6446 PMC8693951__F1 TLR7 signaling in lupus B cells 613 81622 51284 54106 7189 4615 51135 3654 121260 3665 6772 55024 3663 80231 3458 PMC8805653__F1 IL-33/ST2 pathway and its conceptual role following ischemic stroke 90865 4615 3556 3654 51135 7189 7099 PMC8817240__F7 Sam68 contributes to intestinal inflammation in experimental and human colitis 5970 3627 729230 1437 7124 PMC8817698__F3 MAVS Immune Recognition Pathway in Viral Infection and Sepsis 57506 29110 3661 3665 PMC8894518__F3 Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy 10683 28514 54567 3714 182 4851 4853 4855 4854 367 1499 324 2932 7045 4087 4088 4089 PMC8914507__F2 Contributions of glycolytic intermediates and glutamine to collagen protein synthesis 26227 29968 5723 6472 2744 PMC8958553__F1 AKI and CKD affect FGF23 via inflammatory, iron deficiency, anemia, and metabolic related pathways 3569 6774 3934 84876 2056 8074 4018 2475 2308 3479 PMC9006750__F1 Pathway choice in replication-coupled ICL repair 10293 55247 7415 57697 PMC9042933__F1 NRF2 Expression Under Different Conditions 9817 9978 8452 1728 3845 1029 PMC9149100__F1 CDK4 and CDK6 pathway in cancer 1019 1021 1499 595 1030 367 1017 993 7153 PMC9167730__F3 TLR-dependent signaling pathways are modulated by allosteric activation of CD11b 6714 6850 2309 4615 3661 PMC9218499__F1 Taste Receptors in Innate Immunity and Oral Health 5330 29850 255022 64806 PMC9246655__F4 Insights from two independent transcriptomic studies of the bovine corpus luteum during pregnancy 4217 5728 111 8228 1109 9249 3486 145226 4214 7704 5371 8805 6604 PMC9273267__F1 Ferroptosis at the crossroads of tumor-host interactions, metastasis, and therapy response 8031 7018 55240 30061 121549 10162 23657 6520 2879 PMC9339518__F1 NAD+ redox balance, consumption and synthesis 93100 23475 10135 125061 8564 8942 23498 130013 PMC9343460__F8 Effect of PINK1 on Alzheimer’s disease-like pathology induced by intracerebroventricular injection of forskolin in rats 2932 9817 4094 1728 PMC9371363__F1 Canonical and non-canonical IL-4 and IL-13 signaling pathways: 3566 3718 5266 3667 6778 3716 6714 7297 3717 6774 3598 PMC9487300__F7 Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis 7124 3082 7018 3596 3565 PMC9510148__F2 Contribution of altered neuronal autophagy to neurodegeneration 2475 100187761 9776 9706 60673 8408 PMC9525297__F8 Schematic presentation of  process involved in the inhibitory effect of SC on TNBC metastasis 7124 2146 1003 PMC9597127__F3 Major STING combinatorial approaches with additive or synergistic effects 115004 6774 324 PMC9604498__F10 Model integrating the network involving Churc1, Nodal and Notch-dependent pathways in the induction and segregation of germ layers in the Xenopus MZ 91612 6657 4838 4851 9839 6862 57801 28514 PMC9612852__F2 Intracellular checkpoint of IL-15 signaling in human or murine NK cells 2885 7494 3716 6774 9846 3002 8320 55611 3601 3718 2475 2308 PMC9614394__F11 Schematic mechanisms by which Wnt agonist 1 (Wnta1) regulates atrial atrial natriuretic peptide (ANP) secretion and mechanical dynamics 10454 1386 51176 6929 6925 PMC9618966__F6 Macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer 7098 3661 4615 9961 5879 4049 4609 2353 3725 PMC9619051__F1 Perspectives of herbs and their natural compounds, and herb formulas on treating diverse diseases through regulating complicated JAK/STAT signaling 7124 4397 6774 59067 3976 5008 246778 3558 8651 6775 2056 3091 1956 28755 6778 260431 PMC9619213__F2 Follistatin-like protein 3 in human non-tumor pathophysiologies and cancers 8038 4088 4087 10272 23411 4318 4313 3553 948 10413 151534 100506492 1499 PMC9619486__F1 In silico investigation of the role of vitamins in cancer therapy through inhibition of MCM7 oncoprotein 4176 8318 4174 4172 4171 4175 4173 PMC9622788__F2 Regulatory necrosis in traumatic brain injury 59272 140609 9447 114548 3553 79792 192111 7099 PMC9626853__F1 Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery 718 716 5648 717 721 720 730 729 PMC9630482__F2 Extracellular vesicles as advanced therapeutics for the resolution of organ fibrosis: Current progress and future perspectives 2932 1499 4087 4089 4088 4092 655 4090 4086 PMC9631451__F8 Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer 5743 836 5602 8517 2932 5599 7157 3569 5600 7422 3551 3717 7124 3725 5594 5747 842 5579 2033 595 2774 5578 673 5566 5604 PMC9631787__F1 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 59272 7045 4088 4087 4615 22926 4353 PMC9631787__F3 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 59272 2475 1950 999 7040 7189 4087 4088 57291 1000 PMC9632440__F7 Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer’s disease 7124 581 3569 3725 5743 2932 572 596 PMC9634190__F1 Association Between Gut Microbiota, Toll-Like Receptors, and Colorectal Cancer 7100 4615 51284 51311 54106 7096 7097 114609 51135 3656 7189 10333 7099 3661 3665 7187 29110 7098 PMC9635594__F2 Mucin’s role in epithelial to mesenchymal transition (EMT) 999 6774 1000 6935 4585 4586 94025 PMC9636403__F1 Identification of TCF1+ progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade 6418 925 940 1234 6357 729230 3702 5367 719 7535 2358 6363 2833 1524 1230 58191 10663 6368 3135 3107 3659 4599 10581 3434 3105 3106 8519 3433 914 926 2022 917 916 29126 920 919 915 80380 5551 PMC9637027__F2 A3A (A) and A3B (B) expression by HPV 834 6773 7332 9978 8453 1874 171017 1876 PMC9637033__F2 miRNAs: The Key Regulator of COVID-19 Disease 59272 7113 29102 PMC9637672__F12 Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules 200186 5741 4234 7421 1591 8074 PMC9647059__F1 Neuroinflammation in retinitis pigmentosa: Therapies targeting the innate immune system 3717 6774 6347 8651 9021 1907 3554 4615 1910 3976 114548 3603 PMC9647096__F2 Regulatory pathway and possible targets of ferroptosis in HCC 3418 2182 23657 6520 26528 25824 8463 468 55847 59344 2553 2495 2954 7317 5768 1956 4495 10057 PMC9647626__F2 microRNAs associated with the pathogenesis and their role in regulating various signaling pathways during Mycobacterium tuberculosis infection 7096 7097 10333 4615 4118 7189 494334 100422910 7039 1950 100422990 100302122 7124 6774 596 2475 8772 PMC9648404__F8 Sexual dimorphism of early transcriptional reprogramming in degenerating peripheral nerves 3976 3265 7124 4792 2069 2247 1847 8473 1543 2155 1440 3082 7040 1734 1950 3458 183 1544 2852 5741 5595 5155 1956 1385 2147 1906 328 5894 3562 2002 5447 3553 2064 PMC9651583__F4 Integrated text mining and PPI for the combined effects of Hst and VCR on cancer-related signaling pathways 7124 331 4609 3725 5743 3569 2353 7157 841 836 7422 2475 596 5728 3630 7040 5599 842 4117 PMC9652959__F2 Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways 4041 4040 1499 2932 324 51701 6010 4089 4086 4092 4091 PMC9652959__F4 Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways 7189 3725 2353 4286 6010 648 51684 PMC9653755__F2 Current Status and Prospects of Targeted Therapy for Osteosarcoma 5163 2475 6790 9212 7465 PMC9653759__F1 Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability 581 331 115004 3661 PMC9653866__F2 BTN3A: A Promising Immune Checkpoint for Cancer Prognosis and Treatment 324 3458 3717 10384 11119 6774 11118 3565 PMC9653955__F13 Phytocannabinoid Compositions from Cannabis Act Synergistically with PARP1 Inhibitor against Ovarian Cancer Cells In Vitro and Affect the Wnt Signaling Pathway 1499 22943 1856 2155 51393 5888 PMC9654040__F2 Whole New Comprehension about ncRNA-Encoded Peptides/Proteins in Cancers 1499 619501 2932 2638 324 57650 1956 5163 6714 PMC9654658__F1 Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response 3458 8161 7908 7054 7124 7040 6955 6957 3122 3600 3586 PMC9654795__F1 Ferroptosis: A New Development Trend in Periodontitis 8031 6520 2879 23657 27165 4088 4015 10162 5743 4771 2182 PMC9654807__F1 Prognostic and Therapeutic Potential of DNA Damage Repair Pathway Alterations and Homologous Recombination Deficiency in Lung Cancer 142 7508 5887 472 545 79728 672 675 5888 PMC9656460__F1 Ferroptosis of Endothelial Cells in Vascular Diseases 8031 2182 10162 55240 5447 2879 23657 2643 1719 PMC9656488__F2 DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex 545 1111 4361 993 10111 472 11200 995 PMC9656535__F5 Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight 1019 595 1017 1000 999 PMC9656741__F3 PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer’s Disease 10347 945 2041 26278 9026 57091 5664 4137 6653 123041 23208 2580 6311 54664 23064 120892 23400 9896 55823 4854 80208 PMC9656931__F10 Protective Effect of the Polysaccharides from Taraxacum mongolicum Leaf by Modulating the p53 Signaling Pathway in H22 Tumor-Bearing Mice 920 930 581 PMC9657658__F2 Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells 22926 7186 64127 10392 PMC9659743__F2 Dynamic and static biomechanical traits of cardiac fibrosis 9780 6010 545 59341 PMC9661362__F2 Central Adiponectin Signaling – A Metabolic Regulator in Support of Brain Plasticity 51094 79602 26060 5465 3630 7248 7249 PMC9661523__F4 Non-cardiomyocytes in the heart in embryo development, health, and disease, a single-cell perspective 6899 5629 10630 948 2167 28984 762 3569 6347 3383 6376 54567 1948 56920 10516 2006 84870 2532 64093 4883 1009 4772 4915 PMC9661723__F2 Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay 5976 56006 55181 23049 9704 26019 23293 23381 9887 PMC9662265__F1 Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion 9242 1901 10628 55553 PMC9663771__F2 Angiopoietins in Neovascular Diabetes-Related Retinal Diseases 1003 5879 387 PMC9666367__F2 Cellular phenotypic transitions in diabetic nephropathy: An update 2260 387 1499 4041 4040 6608 PMC9666724__F4 Functional and clinical characteristics of focal adhesion kinases in cancer progression 8205 6352 6354 3627 7042 7424 6714 PMC9667740__F1 Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment 966 920 5648 2271 221981 5654 PMC9669482__F4 Ferroptosis and its role in skeletal muscle diseases 6520 23657 2879 PMC9669583__F3 8p11 myeloproliferative syndrome: Genotypic and phenotypic classification and targeted therapy 6772 6774 2308 2885 2549 10818 7249 PMC9673340__F9 N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway 54890 10642 100505696 2669 1487 PMC9674619__F4 Mechanism of mutp53 in ferroptosis 23657 6520 2879 27165 1994 401253 875 5743 7874 6303 29117 239 81894 1803 27035 1026 PMC9678096__F7 Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway 6657 23411 619501 PMC9678227__F9 Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NFKB signaling pathway 3717 6774 3553 9021 PMC9678415__F7 Systematic review of the biological mediators of fat taste and smell 6714 6786 29850 255022 PMC9684170__F3 Hypersensitivity reactions to small molecule drugs 718 715 716 717 6774 721 117194 1431 729 730 735 PMC9686289__F8 Exploring the pathogenesis linking traumatic brain injury and epilepsy via bioinformatic analyses 2113 6772 7107 2992 55108 10154 3635 192670 10220 53615 10261 84263 5286 83716 200205 PMC9686921__F6 NADPH Oxidase 5 (NOX5) Overexpression Promotes Endothelial Dysfunction via Cell Apoptosis, Migration, and Metabolic Alterations in Human Brain Microvascular Endothelial Cells (hCMEC/D3) 54853 6159 6143 6158 11224 6595 6164 6204 5094 6193 PMC9687146__F5 Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism 472 545 1017 6657 79923 960 PMC9687454__F2 Tirzepatide—Friend or Foe in Diabetic Cancer Patients? 2696 3486 3479 3480 4060 2475 PMC9687797__F3 Epigenetics in the Development and Progression of Multiple Myeloma 6774 9759 468 55384 PMC9687819__F3 Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism 115004 3659 3661 PMC9688160__F2 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders 4041 4040 324 2932 1499 7004 8463 7003 7005 147111 PMC9688210__F1 Targeting TET2 as a Therapeutic Approach for Angioimmunoblastic T Cell Lymphoma 54790 387 920 29851 940 2308 2475 PMC9688352__F1 Macrophages and Wnts in Tissue Injury and Repair 1499 2932 324 4041 4040 6259 4920 387 3725 PMC9688488__F1 HIF-1A Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases 90865 6774 3717 4851 PMC9688631__F3 Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia 1019 1021 4193 1017 472 545 PMC9692680__F5 Network Pharmacology- and Molecular Dynamics Simulation-Based Bioprospection of Aspalathus linearis for Type-2 Diabetes Care 2033 5579 1956 5970 3099 5582 3643 PMC9693075__F1 Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss 1950 6469 1956 6608 2932 1499 2735 PMC9693551__F1 Modulatory Effect of Chlorogenic Acid and Coffee Extracts on Wnt/Beta-Catenin Pathway in Colorectal Cancer Cells 2932 1499 324 1081 2638 595 1956 960 8549 PMC9693741__F2 Advances in neovascularization after diabetic ischemia 1499 9353 6091 7428 PMC9694162__F6 PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway in Resveratrol Alleviation of Zearalenone-Induced Oxidative Stress and Apoptosis in TM4 Cells 581 596 9817 PMC9694461__F1 New Therapeutic Trend: Natural Medicine for Ameliorating Ischemic Stroke via PI3K/Akt Signaling Pathway 175 7124 51090 2475 637 355 8772 PMC9695947__F1 Farnesoid X Receptor as a Master Regulator of Hepatotoxicity 64240 64241 1576 1581 1582 1593 9420 PMC9698579__F3 Can Natural Products Targeting EMT Serve as the Future Anticancer Therapeutics? 7077 7078 1000 999 PMC9699386__F5 High Glucose-Induced Cardiomyocyte Damage Involves Interplay between Endothelin ET-1/ETA/ETB Receptor and mTOR Pathway 581 2353 2475 717 PMC9699401__F11 Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression 468 1649 27113 PMC9699542__F4 Mitophagy Induced by Metal Nanoparticles for Cancer Treatment 65018 2475 3091 PMC9699766__F7 lncRNA HHIP-AS1/HHIP modulates osteogenic differentiation of BM-MSCs by regulating Hedgehog signaling pathway 646576 64399 6469 2735 6608 860 PMC9708673__F1 Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases 5136 2475 54790 5139 5141 200316 1789 8654 5422 3417 8564 10846 2581 5027 55627 1213 9829 157807 285190 2802 351 84084 1211 8615 169044 1289 4054 1828 6709 3676 7082 472 675 23476 2033 7450 2251 324 3480 2898 2535 2903 11188 127064 3717 5331 390072 301 5334 5340 719 6469 4194 57521 5275 8243 9126 7157 4627 22918 3707 9611 5295 860 5336 6774 27086 2185 253260 7099 6830 7006 100124696 3718 7494 84466 778 8997 7480 7204 5287 2318 4703 9353 PMC9709415__F1 Protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway 9817 4094 847 PMC9709415__F3 Protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway 2932 9817 847 1728 4615 7099 3553 PMC9709426__F1 Targeting ferroptosis, the achilles’ heel of breast cancer: A review 2643 10162 3156 5447 6520 2879 23657 7018 PMC9710321__F1 Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases? 4803 7442 6774 2932 324 PMC9710325__F2 Perspectives on Challenges in Cannabis Drug Delivery Systems: Where Are We? 572 468 57761 4513 6714 387 PMC9793423__F1 Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights 1392 1270 1178 3976 5008 PMC9793423__F5 Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights 3976 6774 140685 3977 4313 1499 999 6935 2625 595 4322 3397 4193 PMC9878249__F3 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches 7187 57506 29110 3661 3665 PMC9878249__F6 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches 57506 7187 29110 3661 3665 PMC10055176__F8 Changes in Environmental Stress over COVID-19 Pandemic Likely Contributed to Failure to Replicate Adiposity Phenotype Associated with Krtcap3 10018 2296 4488 23435 3156 2222 22937 3638 1356 6720 6721 6307 65985 PMC10149254__F5 Chemical composition of pigeon crop milk and factors affecting its production: a review 6776 3717 5617 6777 9021 PMC10159521__F9 miR-613 suppresses renal cell carcinoma proliferation, invasion and migration by regulating the AXL/AKT pathway 693198 2621 558 PMC10239240__F5 Mettl3 Mediated m6A Methylation Involved in Epithelial-Mesenchymal Transition by Targeting SOCS3/STAT3/SNAI1 in Cigarette Smoking-Induced COPD 3569 3570 6774 9021 999 PMC10239510__F7 Paradigm summarizing the thermogenic and anti-inflammatory properties of YJT via the gut microbiota and related multiple signaling pathways 2865 7054 1734 162514 64127 7099 2867 114770 5111 8993 8477 1733 7442 155 9759 1149 63976 PMC10239798__F7 Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A 3661 55802 6772 6773 PMC10242111__F4 Venetoclax durable response in adult relapsed/refractory Philadelphia-negative acute lymphoblastic leukemia with JAK/STAT pathway alterations 8651 2690 598 2475 8835 6777 5291 5894 5777 3977 3716 4609 6774 3596 3595 1441 7157 4352 596 4170 PMC10243030__F7 NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway 4925 3156 999 1000 PMC10243706__F1 Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies 59307 54472 4615 3654 7099 406938 6774 7097 7100 PMC10244118__F8 Ly6D facilitates chemoresistance in laryngeal squamous cell carcinoma through miR-509/Beta-catenin signaling pathway 8581 1499 8313 5243 4363 PMC10244678__F9 Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway 114548 9965 23063 PMC10308129__F2 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes 4092 4087 3725 7403 6477 83737 7071 PMC10308129__F4 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes 4088 4087 7071 4086 4090 3065 4280 2167 7350 63976 PMC10308129__F7 Krüppel-like factor 10 (KLF10) as a critical signaling mediator: Versatile functions in physiological and pathophysiological processes 3065 729082 7403 1786 7071 5728 283624 90 3625 PMC10308132__F1 Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies 890 25939 7189 115004 3661 3665 PMC10308199__F3 Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes 2805 6821 1036 51380 PMC10308384__F5 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development 361 7099 1604 966 594857 PMC10308384__F9 Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development 7099 2302 288 PMC10308667__F3 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis 7471 100505633 128439 324 221883 5218 27123 2932 607 1499 693162 27086 89780 6659 400604 3159 100507651 400043 PMC10310766__F3 Noncanonical pathway of p53 that regulates ferroptosis 23657 239 95 PMC10310781__F1 Amyloid Beta-based therapy for Alzheimer’s disease: challenges, successes and future 351 23621 25825 PMC10310986__F5 Histone post-translational modification and the DNA damage response 23411 9866 51547 8841 672 PMC10311025__F8 Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response 1101 114548 1687 79792 PMC10311114__F2 Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges 51094 79602 1012 PMC10311182__F1 Key piece of the airway remodeling puzzle revealed—LIGHT signaling in the lung 4055 7186 7187 5971 PMC10372325__F6 Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats 4780 3727 1050 1051 6925 3726 2626 4088 5371 2033 3659 50943 4851 1499 6668 7343 7157 8553 10538 9575 PMC10373173__F2 Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review 4609 7124 4312 PMC10374212__F3 NLRP3: a new therapeutic target in alcoholic liver disease 4615 79792 1571 3553 PMC10375050__F3 Know your neighbors: microbial recognition at the intestinal barrier and its implications for gut homeostasis and inflammatory bowel disease 80216 92610 7189 PMC10375321__F1 One-carbon metabolism comprising the transmethylation pathway, nucleotide synthesis pathway, transsulfuration pathway and remethylation pathway 1719 4397 635 875 4524 10588 10797 4522 PMC10375653__F2 Involvement of the SIRT1-NLRP3 pathway in the inflammatory response 7099 114548 3553 PMC10375783__F3 Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy 7040 23657 6520 472 3458 6772 2182 10162 3845 3146 PMC10375937__F1 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway 7099 4615 51135 7189 PMC10376827__F1 Dissecting the Protective Effect of CD8+ T Cells in Response to SARS-CoV-2 mRNA Vaccination and the Potential Link with Lymph Node CD8+ T Cells 324 355 3458 7124 PMC10376991__F8 An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis 7030 4286 8526 60674 9817 PMC10377129__F9 Active Estrogen–Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells 8648 6390 211 54977 PMC10377462__F10 Molecular Basis of Transglutaminase-2 and Muscarinic Cholinergic Receptors in Experimental Myopia: A Target for Myopia Treatment 4314 1432 10018 2147 4397 4904 3269 1029 7052 1636 183 1950 7053 5595 5599 154 PMC10377641__F3 Leptin: A Heavyweight Player in Obesity-Related Cancers 3717 6774 7018 PMC10377929__F7 Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3B in Cultured Human Dermal Papilla Cells 4041 4040 324 1499 PMC10378680__F5 The Piezo1 Mechanosensitive Channel in Heart Failure 729230 3586 920 9780 7040 3553 3569 PMC10379122__F1 Unravelling the Role of P300 and TMPRSS2 in Prostate Cancer: A Literature Review 367 6462 2078 7113 PMC10379230__F5 Isoflurane Anesthesia’s Impact on Gene Expression Patterns of Rat Brains in an Ischemic Stroke Model 1843 7466 3164 255877 3977 5903 6817 1959 116064 360023 81575 2845 50964 PMC10380015__F2 Challenges and Future Trends in Atopic Dermatitis 3554 90865 6761 4615 7189 27179 10068 PMC10380530__F1 Comprehensive Review: Unveiling the Pro-Oncogenic Roles of IL-1ß and PD-1/PD-L1 in NSCLC Development and Targeting Their Pathways for Clinical Management 11213 51135 3656 3654 7189 4615 79792 PMC10380532__F3 mTOR Signaling Pathway and Gut Microbiota in Various Disorders: Mechanisms and Potential Drugs in Pharmacotherapy 90865 6774 2475 PMC10380640__F4 Crosstalk of Inflammation and Coagulation in Bothrops Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology 717 727 720 5648 10747 735 PMC10380759__F2 Clinical Significance of CD73 in Cancer 84890 941 942 PMC10380946__F1 Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer 637 317 581 572 PMC10382538__F7 Schematic model of the anti-inflammatory effects of IL4I1 on LPS induced-ALI 3459 405 196 PMC10382901__F5 Genetic alterations in MED12 promote castration-resistant prostate cancer through modulation of GLI3 signaling 2744 2737 5447 PMC10383317__F3 Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children 2693 4852 181 627 4915 3953 6492 1363 25970 PMC10384495__F2 Molecular and Genetic Interactions between Obesity and Breast Cancer Risk 2100 2475 6774 3953 51094 79602 PMC10384840__F9 Natural Flavonoids Quercetin and Kaempferol Targeting G2/M Cell Cycle-Related Genes and Synergize with Smac Mimetic LCL-161 to Induce Necroptosis in Cholangiocarcinoma Cells 2717 7186 8717 717 8737 11035 197259 PMC10385932__F1 Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies 3559 8651 3560 467 3716 3718 1958 3702 PMC10473100__F3 Necroptosis and Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Opportunities 7124 11035 197259 28 PMC10473946__F1 Impact of inhaled and intranasal corticosteroids on glucose metabolism and diabetes mellitus: A mini review 2638 3667 51129 PMC10474119__F9 Mechanistic diagram summarizing the regulatory effect of TGR5 in mitochondrial dysfunction and neuroinflammation in Müller cells 5091 3661 115004 29110 PMC10474147__F14 Mechanism underlying oxeiptosis 9817 192111 9131 PMC10474868__F1 Polyhydroxylated Fullerene C60(OH)40 Nanofilms Promote the Mesenchymal–Epithelial Transition of Human Liver Cancer Cells via the TGFB1/Smad Pathway 4089 4087 4088 999 1000 PMC10518396__F7 Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt’s lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib 613 695 2146 7157 331 PMC10520536__GA1 Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/Beta-catenin signaling pathway 2932 1499 324 4087 10276 4088 1277 PMC10520667__F7 LncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death 285987 8408 648 2475 PMC10520719__F11 ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer 652 4185 4090 4086 6658 6657 8324 1499 595 4041 4040 3326 PMC10521506__F10 Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis 8835 22822 100506229 581 7157 PMC10522371__F7 KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling 81930 5728 4313 4318 PMC10522874__F2 Mature white adipocyte plasticity during mammary gland remodelling and cancer 1499 2932 324 4089 4086 4090 4091 51684 6608 PMC10523328__F2 Tactile twist: decoding the phenomena of mechanical itch and alloknesis 114131 4852 93986 799 2925 2922 63895 83737 9780 4879 PMC10525362__F1 Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond 5212 1628 1593 1594 PMC10525517__F2 RUNX1-Regulated Signaling Pathways in Ovarian Cancer 7249 1950 1956 4193 581 PMC10526262__F2 Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets 2475 2932 56339 1116 3958 3959 PMC10526343__F1 Comprehensive Review on Neuroimmunology: Insights from Multiple Sclerosis to Future Therapeutic Developments 920 7412 324 4397 PMC10526800__F3 Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond 4041 2475 10970 22943 255738 4040 5728 3479 3480 10211 PMC10526836__F1 Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential 2885 4117 50615 6774 3716 3718 PMC10527059__F8 Presenilin-1-Derived Circular RNAs: Neglected Epigenetic Regulators with Various Functions in Alzheimer’s Disease 2099 23476 2626 2033 11335 56979 5468 4087 1874 7046 4088 3280 388585 100188776 441478 PMC10529747__F3 TGFB as A Master Regulator of Aging-Associated Tissue Fibrosis 4087 4088 50507 4089 472 PMC10530375__F3 Anti-Inflammatory Effects of Peripheral Dopamine 7474 2932 1499 89780 PMC10530945__F1 Remodeling of Tumor Microenvironment by Nanozyme Combined cGAS–STING Signaling Pathway Agonist for Enhancing Cancer Immunotherapy 115004 3661 7124 PMC10531892__F8 Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients 811 114548 29108 3553 54908 PMC10532049__F1 Angiogenesis—An Emerging Role in Organ Fibrosis 6366 907 9508 1236 140766 7424 54345 PMC10532080__F8 Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/Beta-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer 1499 2932 6657 PMC10533267__F7 sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway 7187 29110 3661 7189 7124 PMC10534279__F3 Growth differentiation factor 15 in cancer cachexia (Review) 4087 4088 4089 4090 4086 9518 2064 389400 5979 2475 PMC10534675__F1 Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases 1283 5053 659 100187907 PMC10534981__F1 Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy 182 3280 23462 84842 3717 PMC10536258__F3 Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke 7422 29949 2919 PMC10536768__F4 Innate Immune Response to Viral Vectors in Gene Therapy 115004 7098 7187 3661 4615 3665 3454 PMC10537080__F2 Critical role of platelet in cancer progression and metastasis 958 387 3383 7412 100507436 4277 6868 PMC10537516__F1 IL-15 and N-803 for HIV Cure Approaches 3601 9021 3716 3718 5770 5771 10401 PMC10537781__F9 African swine fever virus I10L protein inhibits the NFKB signaling pathway by targeting IKKB 8717 7186 10454 23118 4615 9618 3654 7189 PMC10538549__F2 cGAS-STING signaling pathway in intestinal homeostasis and diseases 4582 4583 27040 3606 374 3565 3567 3586 7033 PMC10538549__F3 cGAS-STING signaling pathway in intestinal homeostasis and diseases 115004 3466 3553 PMC10538627__F2 Research progress on the role of the Wnt signaling pathway in pituitary adenoma 11197 1499 4041 4040 54361 8312 2932 8313 324 PMC10539544__F1 GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis 581 6510 81539 2717 2744 2752 PMC10539948__F1 IFNG signalling pathway 2475 9021 8651 3717 3716 254102 5771 6772 PMC10540449__F3 BMP signaling in the development and regeneration of tooth roots: from mechanisms to applications 4090 4086 4093 4089 1834 22943 9314 1499 324 657 90 2932 3381 PMC8478810__F1 Wnt pathway: an important control mechanism in bone’s response to mechanical loading 4041 324 2932 PMC8817718__F2 Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis 114548 834 4615 6850 6774 PMC8817718__F3 Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis 7097 7099 54106 114548 834 PMC8903056__F3 SIRT6 and epigenome maintenance 51548 7486 115004 3240 PMC9124578__F3 Origins and roles of osteoclasts in bone development, homeostasis and repair 1436 7474 10371 51384 10507 4041 4040 50964 PMC9144327__F3 Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials 546 90 2146 7157 340602 4613 PMC9144739__F2 Vaccination against Bacterial Infections: Challenges, Progress, and New Approaches with a Focus on Intracellular Bacteria 958 594857 613 920 3458 PMC9189063__F3 IFNB basal expression through TLR4/TBK/IRF3 pathway 7099 3661 94005 PMC9233125__F1 Box 1. Molecular subtypes and metabolic reprogramming in PDAC 3172 6495 51804 2932 3098 3099 PMC9233125__F2 Genetic alterations induce metabolic reprogramming in PDAC 3845 4609 22934 PMC9248984__F3 Targets for limiting DC maturation / activation 6446 1236 970 941 942 958 PMC9250635__F2 CGAS activity in cells 11277 10084 10146 85364 115004 838 834 837 836 PMC9338018__F1 MiR-30a-centered molecular crosstalk regulates Th17 differentiation 7099 5970 8821 50615 PMC9472579__F1 Insights into pandemic respiratory viruses: manipulation of the antiviral interferon response by SARS-CoV-2 and influenza A virus 1283 7706 29110 3661 4938 51284 7098 9636 115004 6772 6773 PMC9488581__F1 Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review 727897 7015 1832 4353 PMC9488956__F2 Hermansky–Pudlak syndrome pulmonary fibrosis: a rare inherited interstitial lung disease 10981 3257 89781 PMC9489683__F5 Maintaining the regulatory T cell program during inflammation: a delicate balance 90865 29851 4204 2146 50943 54790 200424 1786 1788 84101 7874 4783 3398 201633 10273 3553 PMC9589302__F6 Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NFKB pathway and protecting the intestinal barrier 7099 3654 51135 PMC9616595__F1 Intersection of metabolism and inflammation is governed by the intracellular topology of hexokinases and the metabolic fate of glucose 3098 2597 22933 3099 6280 6279 PMC9619093__F2 Joint together: The etiology and pathogenesis of ankylosing spondylitis 6097 861 6774 11009 9021 8651 7099 PMC9622788__F1 Regulatory necrosis in traumatic brain injury 4199 7186 8717 1540 197259 140805 2932 23237 128866 PMC9622808__F6 Schematic model 1593 9420 100187761 PMC9626029__F3 Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation 6850 695 5336 PMC9630602__F4 Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases 7189 3661 29110 PMC9630901__F12 Synergic Effect of Combined Therapy of Hyperbaric Oxygen and Adipose-Derived Mesenchymal Stem Cells on Improving Locomotor Recovery After Acute Traumatic Spinal Cord Injury in Rat Mainly Through Downregulating Inflammatory and Cell-Stress Signalings 2475 7189 4615 4118 968 2670 PMC9630943__F3 IL-33/ST2 immunobiology in coronary artery disease: A systematic review and meta-analysis 7099 3654 51135 7189 90865 4615 59307 PMC9632889__F10 Potential mechanism of the effects of leonurine attenuating cardiac fibrosis in heart failure 4087 79792 1281 2335 PMC9634088__F2 Immune defenses of the mammary gland epithelium of dairy ruminants 948 7096 114609 4615 7097 10333 7189 7099 7187 3661 7098 10392 64127 3553 PMC9636152__F1 DNA damage signaling pathway 472 3014 9656 9025 165918 580 672 55183 PMC9642324__F1 Immunomodulators: still having a role? 7172 55270 8833 5879 PMC9649783__F7 MYBPC3 deficiency up-regulated NFKB/TGFB1/HIF-1A/aerobic glycolysis signaling cascade in cardiac fibroblasts, contributing to HCM myocardial fibrosis 4607 6347 3553 1277 PMC9650365__F2 Crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease 23410 3920 23411 2475 1508 114548 10628 79792 PMC9652018__F1 Growing Role of the BH3 Mimetic Drug Venetoclax in the Therapy of Acute Myeloid Leukemia 637 581 572 90427 638 PMC9653095__F6 Graphic summary representation of tryptophan metabolism and disposition in cancer biology and proposed therapeutic strategies 8942 8140 6520 23428 PMC9656873__F3 COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs 59272 115004 3661 29110 PMC9656902__F2 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways 693221 999 4851 1000 55000 6657 4609 145258 6935 388585 3280 285194 8650 PMC9656902__F3 Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways 6932 7476 7482 54361 2186 26298 55366 3205 728655 1499 7054 2146 619501 57291 407037 406996 PMC9657855__F9 Storax Attenuates Cardiac Fibrosis following Acute Myocardial Infarction in Rats via Suppression of AT1R–Ankrd1–P53 Signaling Pathway 4193 27063 581 PMC9658815__F2 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications 4087 4089 4088 PMC9658815__F5 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications 5443 7306 4286 PMC9658815__F6 Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications 4312 1728 7124 PMC9658871__F8 Exosome Secretion and Epithelial-Mesenchymal Transition in Ovarian Cancer Are Regulated by Phospholipase D 5337 5338 10631 7431 2335 PMC9659945__F1 Progress of protein synthesis factors eIFs, eEFs and eRFs in inflammatory bowel disease and colorectal cancer pathogenesis 1998 468 3400 PMC9661339__F2 NLRP3 Inflammasome in Parkinson’s Disease and Therapeutic Considerations 948 7097 7099 140609 114548 PMC9662161__F5 Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells 7124 8241 1000 999 595 PMC9662188__F2 Caspase-2–dependent activation of de novo lipogenesis 84818 1717 1718 1581 3949 2194 PMC9667637__F2 Neutrophil extracellular traps in cancer progression, metastasis and therapy 55246 54106 7099 6935 PMC9667637__F3 Neutrophil extracellular traps in cancer progression, metastasis and therapy 3577 7099 54106 4353 PMC9668345__F3 Alterations in the Salivary Proteome and N-Glycome of Sjögren’s Syndrome Patients 5530 7422 3082 1278 4792 6097 5008 6772 2908 3959 3849 3858 5371 10673 PMC9675387__F3 Oncology biosimilars: New developments and future directions 6774 3717 2057 PMC9678997__S1 Tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis 7054 120892 65018 PMC9680067__F6 Teleost NOD-like receptors and their downstream signaling pathways: A brief review 22861 114548 4049 171389 91662 3553 3606 PMC9681895__F3 Effect of maternal body mass index on the steroid profile in women with gestational diabetes mellitus 1583 1586 1588 PMC9684205__F1 Emerging roles of fibroblast growth factor 21 in critical disease 26291 10818 2885 PMC9685423__F1 Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry 9420 1593 10998 23600 8309 1583 3007 3283 PMC9686445__F9 Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations 100187761 1232 10344 7908 8213 PMC9687157__F2 MicroRNAs as Mediators of Adipose Thermogenesis and Potential Therapeutic Targets for Obesity 7099 6347 729230 5468 51094 79602 26060 5465 PMC9688160__F3 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders 9113 26524 4485 9448 8491 11183 11184 5871 558 4041 4040 324 2932 1499 3064 PMC9688160__F4 Crosstalk between the Hippo Pathway and the Wnt Pathway in Huntington’s Disease and Other Neurodegenerative Disorders 9113 4018 4485 PMC9688488__F4 HIF-1A Regulates Bone Homeostasis and Angiogenesis, Participating in the Occurrence of Bone Metabolic Diseases 7078 860 4318 4314 4317 4316 4313 4319 4320 51705 2475 PMC9691847__F6 Baihu renshen decoction ameliorates type 2 diabetes mellitus in rats through affecting gut microbiota enhancing gut permeability and inhibiting TLR4/NFKB-mediated inflammatory response 7099 4615 3553 7124 PMC9693457__F2 Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia 1950 1956 613 PMC9693478__F3 Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex 7482 84870 54361 4158 56246 2146 8313 84133 6423 2487 6608 6469 1499 PMC9693603__F11 Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan 3717 6774 4318 596 581 PMC9699629__F1 Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications 920 10628 51322 2184 3034 PMC9704719__F6 Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation 8140 196 405 PMC9709483__F2 Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms 8864 6095 406 9575 10135 PMC9711860__F7 Illustration of how loss of cell–cell adhesion triggers cell migration 5879 7074 6714 6774 27035 7431 PMC9711961__F8 Paeoniflorin Inhibits LPS-Induced Activation of Splenic CD4+ T Lymphocytes and Relieves Pathological Symptoms in MRL/lpr Mice by Suppressing IRAK1 Signaling 3654 7099 7124 PMC10143456__F7 Dickkopf-1 Acts as a Profibrotic Mediator in Progressive Chronic Kidney Disease 4041 4040 22943 PMC10149954__F2 Receptors that bind to PEDF and their therapeutic roles in retinal diseases 4041 4040 1499 2932 324 4316 4313 7124 652 4318 PMC10151263__F8 Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway 7442 2475 7942 8408 PMC10151556__F1 An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review 2308 10628 114548 3553 PMC10151763__F1 Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy 101 1499 7049 1958 4088 4087 387 4089 8074 7099 3480 3479 PMC10242177__F1 Myostatin: a potential therapeutic target for metabolic syndrome 4087 4088 2660 4089 PMC10244093__F9 Linc00662 m6A promotes the progression and metastasis of pancreatic cancer by activating focal adhesion through the GTF2B-ITGA1-FAK pathway 148189 10643 2959 3672 6714 PMC10244910__F10 Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGFB/Smad signaling pathways 7048 4088 4087 PMC10300409__GA1 Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response 619537 3601 3600 920 PMC10377024__F8 Landscape of Genetic Mutations in Appendiceal Cancers 4089 7048 4087 4088 7046 PMC10379139__F2 Genetic Risk Factors Related to Coronary Artery Disease and Role of Transforming Growth Factor Beta 1 Polymorphisms 7040 7042 7043 4089 7049 4087 7048 4088 7046 PMC10382948__F1 Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology 1582 1593 1581 9420 PMC10383069__F2 Understanding the Roles of Very-Long-Chain Polyunsaturated Fatty Acids (VLC-PUFAs) in Eye Health 60481 54898 64834 83401 6785 PMC10388466__F7 Peptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NFKB activation via disrupting multiple-site ubiquitination of NEMO 221476 81858 301 PMC10388482__F9 SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression 7424 7422 7423 PMC10472599__F8 Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML 969 947 2475 595 1021 7852 6387 9242 7157 6418 PMC10474176__F6 NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway 9039 1437 6347 3553 5132 PMC10518420__F3 An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment 619501 6935 84890 4088 3458 PMC10520362__F3 Mammalian Intestinal Development and Differentiation—The State of the Art 653 27122 84870 7482 8549 2300 PMC10520887__F9 Porcine IKKE is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway 3661 115004 29110 PMC10525532__F4 Thioredoxin/Glutaredoxin Systems and Gut Microbiota in NAFLD: Interplay, Mechanism, and Therapeutical Potential 10628 114548 3553 PMC10525672__F3 Stress Urinary Incontinence: An Unsolved Clinical Challenge 7046 4089 4087 PMC10526378__F3 Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors 3717 6774 9021 PMC10530547__F3 Transcription Factor Zbtb20 as a Regulator of Malignancy and Its Practical Applications 4313 4318 494327 406996 1523 406906 26137 5468 1499 693219 1956 174 595 PMC10530558__F1 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells 3091 4609 4613 3845 PMC10530962__F2 Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications 4089 4088 4087 PMC10531214__F3 Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications 3716 6772 6776 3717 6773 3572 6777 3718 6774 6778 7297 6775 PMC10532419__F4 LOXL2 in Cancer: A Two-Decade Perspective 5159 4017 7424 PMC10532491__F2 Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer 1950 2064 7039 1956 2885 3082 PMC10534925__F3 Epidermal Growth Factor Receptor-Targeted Neoantigen Peptide Vaccination for the Treatment of Non-Small Cell Lung Cancer and Glioblastoma 941 942 940 355 PMC10536099__F6 Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections 163702 3716 6772 10379 4938 3434 PMC10536768__F2 Innate Immune Response to Viral Vectors in Gene Therapy 7097 54106 115004 4615 7099 3665 29110 3661 3454 PMC10536768__F3 Innate Immune Response to Viral Vectors in Gene Therapy 54106 7097 4615 115004 3665 29110 3661 PMC10537261__F3 Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis 23237 181 4852 PMC10537735__F10 Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NFKB Signaling Pathway 100187907 1513 4772 PMC10538533__F1 Updated roles of cGAS-STING signaling in autoimmune diseases 115004 7506 3661 PMC10540347__F10 SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3B signaling pathway through P53 6713 2932 5728 PMC8478810__F2 Wnt pathway: an important control mechanism in bone’s response to mechanical loading 4038 4041 50964 22943 PMC8478810__F4 Wnt pathway: an important control mechanism in bone’s response to mechanical loading 4041 54894 84133 55366 8549 59352 284654 PMC9131857__F9 Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly 7189 4615 114548 PMC9187215__F1 Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? 3716 3394 7297 6772 6773 10379 3663 3665 4088 4087 PMC9187215__F2 Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? 5132 3455 6772 3716 6773 7297 3663 PMC9233125__F3 Link between inflammatory mediators, autophagy, and metabolic reprogramming 11009 7054 2806 2805 2920 PMC9488512__F3 Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis 2254 2255 6469 PMC9488800__F4 Multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease 4049 283871 4050 3579 PMC9489610__F1 Immunological outcomes of apoptosis versus programmed necrotic mechanisms 286410 55113 7448 10461 PMC9633854__F3 Choroid plexus epithelium and its role in neurological diseases 3458 920 1356 PMC9640836__F4 PAX5 alterations in B-cell acute lymphoblastic leukemia 84186 5079 2006 2120 3717 1029 PMC9641817__F4 Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease 5132 3620 920 PMC9641982__F2 Innate immune mechanisms of mRNA vaccines 2638 4615 7098 51284 51311 3661 3665 3716 6772 6773 10379 3627 7124 920 3717 PMC9649744__F4 New insights into the characteristics of DRAK2 and its role in apoptosis: From molecular mechanisms to clinically applied potential 4088 4089 4087 PMC9655983__F9 Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway 3553 6347 2919 7038 PMC9656419__F3 Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease 4609 6772 6774 PMC9658666__F2 Pathways of Angiogenic and Inflammatory Cytokines in Multiple Myeloma: Role in Plasma Cell Clonal Expansion and Drug Resistance 3553 3082 7124 6423 22943 PMC9666786__F1 Crosstalk between enteric serotonergic neurons and colorectal cancer stem cells to initiate colorectal tumorigenesis 121278 8312 1499 595 3351 3352 3355 PMC9675748__F6 Consequences of HDAC6 activity inhibition regulation through TubA treatment in DMD mice model 2475 4088 10013 PMC9676400__F7 Chicken anemia virus VP1 negatively regulates type I interferon via targeting interferon regulatory factor 7 of the DNA-sensing pathway 29110 3665 115004 PMC9686445__F6 Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations 1392 1394 3569 4803 PMC9687047__F8 Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo 7099 90865 3654 51135 7189 4615 114548 PMC9687819__F2 Alteration of the IFN-Pathway by Human Papillomavirus Proteins: Antiviral Immune Response Evasion Mechanism 3716 6772 10379 56832 7297 6773 4938 91543 115004 3717 PMC9692260__F3 Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical 7124 3383 7412 PMC9694413__F3 Biodegradation and Metabolic Pathway of the Neonicotinoid Insecticide Thiamethoxam by Labrys portucalensis F11 51075 54495 56255 PMC9699419__F2 Cluster C19MC in Pre-Eclampsia Development 668 4929 5069 4313 6372 7128 114548 PMC9710844__F7 Graphical abstract of DDOST-regulated MITA-mediated signaling pathway 115004 29110 3661 PMC9878249__F4 SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches 57506 7187 29110 3661 10146 PMC10473147__F2 Neuroinflammation: A Common Pathway in Alzheimer’s Disease and Epilepsy 2670 968 54209 3553 PMC10531214__F4 Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications 3976 29949 11009 PMC9669749__F2 Inflammatory pathophysiological mechanisms implicated in postpartum depression 50943 3569 114548 PMC10244098__F2 N7-methylguanosine modification: from regulatory roles to therapeutic implications in cancer 10785 8731 96764 PMC10375641__F5 Super-enhancers complexes zoom in transcription in cancer 4609 619501 6657 4149 2353 642587 100506119 1956 PMC9434547__F1 Lactate metabolism in human health and disease 51441 100379198 383 PMC9627168__F2 Lactate drives cellular DNA repair capacity: Role of lactate and related short-chain fatty acids in cervical cancer chemoresistance and viral infection 2867 2865 266790 197257 PMC9691176__F1 Vascular Endothelial Growth Factor Receptor 2: Molecular Mechanism and Therapeutic Potential in Preeclampsia Comorbidity with Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections 7422 7423 5281 998 7424 PMC10239497__F10 Dissecting specific Wnt components governing osteogenic differentiation potential by human periodontal ligament stem cells through interleukin-6 4041 4040 10023 324 1499 PMC10239817__F1 Peptides in reversing chemoresistance of breast cancer: current facts and future prospects 6623 2064 574045 PMC10382489__F3 PTMs involve some mechanisms in CVDs 55669 9927 5763 8454 10628 PMC8817698__F4 MAVS Immune Recognition Pathway in Viral Infection and Sepsis 57506 57762 79671 220213 PMC9646879__F7 Various biological functions of the human Rix1 scaffolding complex 27043 26168 54881 PMC9654020__F1 Looking into Endoplasmic Reticulum Stress: The Key to Drug-Resistance of Multiple Myeloma? 22926 7494 7186 468 90550 10645 2475 PMC10374588__F4 Graphical depiction of the mechanism of classical pyroptosis pathway and non-classical pyroptosis pathway 4615 7099 3553 79792 PMC10526378__F1 Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors 2475 1956 6774 PMC10539668__F8 TNFA counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes 4067 9021 7297 3716 6774 PMC9681871__F2 SMAD-(in)dependent bone morphogenetic protein (BMP) signalling pathway (oversimplification) 387 64750 57154 PMC10540835__F1 Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe? 114548 7054 3553 PMC9690211__F6 Transcriptome Analysis of Chinese Cabbage Provides Insights into the Basis of Understanding the Lignin Affected by Low Temperature 790 1312 7414 PMC10137778__F9 Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (O. niloticus) Subjected to Chronic Stress Reveals Signaling Pathways Associated with Depressed Growth 7275 5979 183 PMC10138871__F7 NpPP2-B10, an F-Box-Nictaba Gene, Promotes Plant Growth and Resistance to Black Shank Disease Incited by Phytophthora nicotianae in Nicotiana tabacum 847 6500 8454 PMC10149907__F5 Regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer 3417 5230 4967 PMC10149931__F9 Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction 1606 940 3932 2534 998 PMC10150162__F9 Progress in non-viral localized delivery of siRNA therapeutics for pulmonary diseases 3845 5898 5728 729230 6347 PMC10152377__F1 Somatic Variants Activating Ras/Raf/Mitogen-Activated Protein Kinase (MAPK) Pathway Genes in Mesial Temporal Lobe Epilepsy 2885 2002 4763 PMC10152446__F7 Structure Elucidation and Biosynthesis of Nannosterols A and B, Myxobacterial Sterols from Nannocystis sp. MNa10993 10682 4598 1717 10654 1718 3652 PMC10237620__F1 MTOR signaling pathway in cardiac aging 7248 7249 64223 64798 2475 9776 8408 65018 6446 4485 6010 PMC10239456__F3 Interaction graph and dynamic behavior of the PanNETs Boolean model 1616 4193 7157 3651 4221 6502 5728 4609 PMC10242022__F1 Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis 3098 10295 355 2597 79717 53354 5471 60490 PMC10242764__F7 Molecular Mechanisms of Notopterygii rhizoma Et Radix for Treating Arrhythmia Based on Network Pharmacology 472 545 581 84883 1017 64065 5728 637 64326 4193 842 836 2475 PMC10242999__F2 Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer 3717 7018 998 6714 PMC10288531__F3A Differential Pathway Expression of Antigen Processing and Presentation 821 7124 3458 51596 811 567 6892 1508 920 PMC10311035__F1 Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders 4041 324 1499 6259 387 PMC10312162__F4 Changes in the metabolic pathways of young and old leaves in the two soybean ecotypes 7851 102659353 2147 1636 PMC10313304__F9 Exploring the active ingredients and mechanism of Shenzhi Tongxin capsule against microvascular angina based on network pharmacology and molecular docking 355 929 7124 8717 7186 1616 23118 5894 2316 4352 2444 51701 2002 4149 3727 4208 6722 PMC10313451__F6 Imipramine mechanism of action in breast cancers 1019 545 672 2078 PMC10373097__S1 Rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy 4827 5350 2475 PMC10374032__F1 Genome-scale metabolic modeling and in silico analysis of opportunistic skin pathogen Cutibacterium acnes 51287 9200 2752 4199 4118 1431 11113 6120 4311 10249 3145 1823 191 PMC10376516__F4 Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics 581 637 2475 PMC10377020__F1 ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review 7494 9817 468 PMC10380296__F6 Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus 2717 3466 3939 5163 5447 2056 1950 7012 226 1537 PMC10380296__F7 Transcriptional Modulation Reveals Physiological Responses to Temperature Adaptation in Acrossocheilus fasciatus 66037 6850 613 930 3667 5879 5728 5266 7249 572 828 6256 4193 388 8161 PMC10380572__F2 Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients 27040 4067 695 2885 PMC10380707__F2 Inflammation, Dopaminergic Brain and Bilirubin 4513 3569 6387 7099 4397 3596 3162 1810 7054 1312 847 54658 PMC10380887__F1 MTOR Signaling: Emerging Role of Cyclic Nucleotide-Dependent Protein Kinases and Implications for Cardiometabolic Disease 2887 64798 5728 5163 7124 7248 7249 6009 2638 23387 PMC10381408__F4 Compound K Production: Achievements and Perspectives 3652 55276 4099 PMC10383295__F3 Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells 7054 2475 672 572 8772 8717 581 6648 637 PMC10384200__F4 Association between High Interferon-Gamma Production in Avian Tuberculin-Stimulated Blood from Mycobacterium avium subsp. paratuberculosis-Infected Cattle and Candidate Genes Implicated in Necroptosis 7124 2242 3466 8772 3014 7187 3661 9825 1540 637 27005 11035 197259 5836 5447 5008 3146 90865 4015 PMC10384352__F3 Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections 9474 10010 10859 3661 6850 PMC10384750__F1 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer 2475 64223 8408 64422 6010 6446 PMC10388730__F6 Influence of cold-stimulated adipocyte supernatant on the expression of adhesion-related molecules in Schwann cell line 627 7124 1950 355 929 7189 7186 1616 23118 51295 5894 3240 2316 1399 4351 51701 4117 3727 4149 6722 8161 PMC10389837__F3 Research Progress on the Etiology and Pathogenesis of Alzheimer's Disease from the Perspective of Chronic Stress 1392 2932 1020 23621 PMC10474053__F5 Dysregulation of Ca2+ channels and pumps in metabolic diseases 90550 5350 6786 200186 7942 PMC10521544__F6 Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma 847 367 790 10763 4145 8567 4201 572 1537 140805 6402 8161 3242 PMC10525272__F5 Canine Somatic Mutations from Whole-Exome Sequencing of B-Cell Lymphomas in Six Canine Breeds—A Preliminary Study 858 859 613 5266 3270 5350 10345 90550 PMC10525526__F1 Phenotype Alterations in the Cecal Ecosystem Involved in the Asymptomatic Intestinal Persistence of Paratyphoid Salmonella in Chickens 10818 126669 1398 2885 2549 7189 387 572 PMC10525949__F6a Transcriptomics Reveal the Effects of Breeding Temperature on Growth and Metabolism in the Early Developmental Stage of Platax teira 126669 335 4023 5360 4312 7316 1376 7350 3611 PMC10526229__F1 Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies 4853 4854 4855 5045 6476 2475 100188776 28514 10683 54567 PMC10526250__F1 Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression 1869 572 581 PMC10527326__F2 The Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis 10330 340061 9817 3667 8204 847 2593 1499 PMC10531449__F3 Transcriptomics of Canine Inflammatory Mammary Cancer Treated with Empty Cowpea Mosaic Virus Implicates Neutrophils in Anti-Tumor Immunity 8161 8178 8772 23118 257397 4703 7975 7054 3934 PMC10535041__F5 Antagonistic Activity of Oroxylin A against Fusarium graminearum and Its Inhibitory Effect on Zearalenone Production 2271 2539 25796 5226 22934 50 PMC10539095__F2 Molecular Basis of Wnt/Beta-Catenin Signaling Pathways in Neurodegenerative Diseases 2147 6259 23002 6010 PMC10540234__F8 Sulforaphane and bladder cancer: a potential novel antitumor compound 4055 5971 958 PMC10540641__F9 Schematic representing the manufacturing process of a targeted delivery system 4313 960 100187761 PMC8632930__F1 Antitumor effect of PARP inhibitors 6741 1105 367 7515 1106 672 472 675 79728 5888 7517 7516 PMC9125579__F10 Contribution of Mitochondria to Insulin Secretion by Various Secretagogues 948 150763 84803 137964 7038 4099 847 7226 100170220 29850 54795 6616 7220 6786 139760 7222 84876 PMC9156568__F15 Characterizing the Propagation Pathway of Neuropathological Events of Alzheimer’s Disease Using Harmonic Wavelet Analysis 27040 3630 5426 PMC9319223__F2 Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation 4353 4536 4512 4513 4535 4537 355 4514 4519 4541 4538 4539 3792 4899 847 PMC9553103__F2 ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain 952 5167 203 84890 100 4860 PMC9569545__F1 Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing 6741 55669 9927 PMC9622788__F4 Regulatory necrosis in traumatic brain injury 8717 11035 664 79792 4282 PMC9623116__F1 Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential 90550 6786 57620 PMC9630602__F2 Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases 4615 7189 3661 114548 834 1687 79792 5728 2308 4193 PMC9632414__F1 Editorial: Dissection of the molecular basis of fatty acid composition in oil crops and molecular breeding of oil crops with improved fatty acid composition 84649 355 54861 4018 PMC9637639__F6 Identification of the effect and mechanism of Yiyi Fuzi Baijiang powder against colorectal cancer using network pharmacology and experimental validation 4434 387569 266710 842 5900 324 572 4609 2956 51426 PMC9637915__F6 Proteomics unveil a central role for peroxisomes in butyrate assimilation of the heterotrophic Chlorophyte alga Polytomella sp. 847 5829 47 5132 4434 PMC9641012__F7 Quantitative proteomic analysis reveals the molecular mechanism of the Yesso scallop (Patinopecten yessoensis) in response to Polydora infection 4026 4074 274 5058 PMC9647060__F4 Transcriptome and metabolome analyses provide insights into the relevance of pericarp thickness variations in Camellia drupifera and Camellia oleifera 1312 790 6738 PMC9648792__F8 Comprehensive analysis of prognostic significance of cadherin (CDH) gene family in breast cancer 613 3565 4803 3265 6010 84433 5966 759 5879 572 930 998 2475 PMC9655409__F8 Neuromedin S Regulates Steroidogenesis through Maintaining Mitochondrial Morphology and Function via NMUR2 in Goat Ovarian Granulosa Cells 129521 56923 4485 9113 26524 51083 6770 PMC9656873__F1 COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs 59272 114548 1017 25939 3661 PMC9657932__F2 Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside 1956 6722 2885 2002 5728 PMC9664149__F6 Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation 4353 847 9241 2876 260431 1401 PMC9664149__F8 Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation 4353 6955 1636 847 59272 100187761 1401 PMC9666724__F6 Functional and clinical characteristics of focal adhesion kinases in cancer progression 1956 387 9113 26524 3065 3066 PMC9666758__F3 Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome 154796 166824 2264 4771 60485 4485 PMC9670321__F2 GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models 2776 5163 2475 7204 6010 154796 PMC9674421__F11 Expression and Prognostic Significance of PDIA3 in Cervical Cancer 468 22926 4397 581 100187907 258010 7327 7316 6500 PMC9675292__F1 Insulin Receptor Substrate Signaling Controls Cardiac Energy Metabolism and Heart Failure 2147 5091 2645 2539 5166 2194 PMC9683098__F6 ECM-associated protein secretion and intracellular accumulation in dermal fibroblasts 730 7052 6396 4088 4087 PMC9685520__F1 Phase separation drives the formation of biomolecular condensates in the immune system 115004 29110 23613 PMC9687179__F1 Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription 466 2203 9815 PMC9694420__F1 PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-Negative 717 5728 5163 695 5266 PMC9701395__F9 Computation and molecular pharmacology to trace the anti-rheumatoid activity of Angelicae Pubescentis Radix 6714 998 842 572 4513 PMC9705465__F3 Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases 875 23474 7263 6821 847 1610 PMC9705782__F1 Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome 4553 26523 192669 27161 192670 PMC9707336__F5 M6A methylation profiles of immune cells in type 1 diabetes mellitus 9365 355 929 8027 7124 8717 64167 1616 1610 8213 10379 2316 51701 4703 2002 4149 10750 PMC9707336__F6 M6A methylation profiles of immune cells in type 1 diabetes mellitus 6850 7124 930 355 929 8717 2885 5728 7186 1616 23118 951 51295 572 1610 5894 51701 4193 4149 5934 1537 PMC10138955__F5 Comparative Genomic Analysis of a Methylorubrum rhodesianum MB200 Isolated from Biogas Digesters Provided New Insights into the Carbon Metabolism of Methylotrophic Bacteria 4118 759 8178 440823 PMC10141597__F1 Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids 613 958 4155 PMC10151533__F2 Developmental origin of tendon diversity in Drosophila melanogaster 6092 6091 64221 3343 1956 PMC10152985__F15 Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications 7318 55236 79876 10533 7316 79654 10075 4734 11059 9978 8454 51444 55658 55294 6502 7706 8314 PMC10229232__F1 Krüppel-homologue 1 regulates the development of Tuta absoluta and its cascade regulation pattern in the juvenile hormone signalling pathway 4173 990 26523 6161 PMC10239924__F1 Raptor in lymphocytes differentiation and function 64223 10645 2475 7249 7248 6009 64798 5163 2308 2309 PMC10243112__F7 Machine Learning Reveals Lipidome Remodeling Dynamics in a Mouse Model of Ovarian Cancer 717 7038 5091 729 PMC10244546__F1 Potential of epigallocatechin gallate in the chemoprevention and therapy of hepatocellular carcinoma 581 6774 975 2475 PMC10288531__F2A Differential Pathway Expression of Cardiac Muscle Contraction Pathway 10345 3270 7006 100124696 7054 845 3371 PMC10304357__F1 Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME 3661 115004 7189 PMC10308444__F5 Integrated transcriptome and microRNA sequencing analyses reveal gene responses in poplar leaves infected by the novel pathogen bean common mosaic virus (BCMV) 5091 847 3815 5132 PMC10310980__F1 Circadian clocks in cancer: Mechanisms and clinical implications 9575 1408 1429 2475 581 960 1407 2638 PMC10310985__F4 DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer 1956 2885 5163 2475 5728 6774 2002 7186 324 PMC10311107__F7 Metabolic and transcriptomic analyses elucidate a novel insight into the network for biosynthesis of carbohydrate and secondary metabolites in the stems of a medicinal orchid Dendrobium nobile 1644 5053 8205 1312 PMC10311769__F2 Revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens 4548 4598 4597 3652 PMC10312032__F2 Research progress on the kynurenine pathway in the prevention and treatment of Parkinson’s disease 130013 8564 23475 PMC10373932__F5 Insights into the physiological and genomic characterization of three bacterial isolates from a highly alkaline, terrestrial serpentinizing system 183 275 4397 PMC10374575__F6 GHS-R1a/D2R heterodimers activation in dopaminergic neurons 4280 51083 7054 PMC10377042__F2 Potential Influence of Uremic Toxins on the Homeostasis of Bones and Muscles in Chronic Kidney Disease 4942 196 5741 7350 PMC10378552__F2 Exploring the Molecular Complexity of Medulloblastoma: Implications for Diagnosis and Treatment 51684 6469 6608 5727 2475 PMC10379125__F5 Transcriptome-Wide Identification and Response Pattern Analysis of the Salix integra NAC Transcription Factor in Response to Pb Stress 10090 100170220 8139 7454 PMC10380285__F1 Influence of Single Nucleotide Polymorphisms on Vitamin D Receptor Protein Levels and Function in Chronic Liver Disease 7421 6667 2539 6714 6670 619501 PMC10380440__F2 Sexual Dimorphism of Skeletal Muscle in a Mouse Model of Breast Cancer: A Functional and Molecular Analysis 845 6262 10345 3270 PMC10380517__F2 CDK4/6 Inhibitor Resistance in Hormone Receptor-Positive Metastatic Breast Cancer: Translational Research, Clinical Trials, and Future Directions 2475 1019 1021 2260 7465 PMC10380785__F3 Lignin, the Lignification Process, and Advanced, Lignin-Based Materials 412 790 1312 PMC10380881__F1 Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study 4524 7298 1719 4548 4552 191 875 23028 PMC10383192__F1 Peptide Vaccine Design Targeting KIT Mutations in Acute Myeloid Leukemia 3815 2475 6714 572 PMC10383966__F4 Pellino Proteins in Viral Immunity and Pathogenesis 3661 3665 3654 51135 4615 PMC10383978__F3 Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer 4199 5091 4200 PMC10384366__F1 Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells 1499 4397 2932 100188776 2936 51684 6608 PMC10384750__F3 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer 3667 6009 5163 7248 7249 5728 PMC10389819__F6 C-Phycocyanin Ameliorates the Senescence of Mesenchymal Stem Cells through ZDHHC5-Mediated Autophagy via PI3K/AKT/mTOR Pathway 9242 25921 2475 PMC10389822__F2 Intersection of COVID-19 and Rheumatoid Arthritis: Shared Mechanisms, Treatment Challenges, and Potential Therapeutic Approaches 5970 23476 6774 PMC10472646__F3 Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application 6387 9097 3620 23411 PMC10473115__F1 Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer’s Disease 54209 1611 6850 PMC10473144__F2 Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease 2932 1499 324 22943 4041 4040 PMC10473144__F3 Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease 2932 324 4041 4040 PMC10474053__F3 PI3K-AKT pathway and major upstream effectors in the signaling network 5728 8821 572 5163 2932 253260 7248 7249 6009 PMC10474083__F1 Detailed kinetic model of glycolysis in Plasmodium falciparum-infected red blood cells for antimalarial drug target identification 2020 2019 2539 PMC10519225__F5 Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles 5624 920 567 PMC10522861__F7 Analysis of the response mechanisms of Pinellia ternata to terahertz wave stresses using transcriptome and metabolic data 51411 1879 64641 847 7168 PMC10522995__F1 CREB-Regulated Transcriptional Coactivator 2 Proteome Landscape is Modulated by SREBF1 200186 10993 2776 4397 PMC10526873__F2 G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology 6714 1956 10365 4208 387 PMC10527779__F3 Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View 65018 8301 10280 PMC10528086__F2 When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex 2475 4041 4040 324 1499 PMC10529884__F1 Report from the 24th Annual Western Canadian Gastrointestinal Cancer Consensus Conference on Colorectal Cancer, Richmond, British Columbia, 28–29, October 2022 4266 5395 4436 4292 673 PMC10530558__F6 Illustration of Altered Glucose Dependency in Drug-Resistant Cancer Cells 2539 95 6510 PMC10530615__F1 Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria 79717 60490 5471 PMC10530670__F5 Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes 7124 638 8772 1616 472 3002 835 56616 6955 790 351 PMC10531003__F2 Pathway from Acute Kidney Injury to Chronic Kidney Disease: Molecules Involved in Renal Fibrosis 5340 7939 1499 7225 PMC10531420__F6 Seasonal Developing Xylem Transcriptome Analysis of Pinus densiflora Unveils Novel Insights for Compression Wood Formation 1312 790 57716 PMC10531730__F1 Depiction of Branched-Chain Amino Acids (BCAAs) in Diabetes with a Focus on Diabetic Microvascular Complications 3667 7248 7249 3479 6009 PMC10531820__F6 Regulatory T Cells in Cancer Treatment Resistance 920 2475 5728 PMC10531837__F2 Exploring the Complex and Multifaceted Interplay between Melanoma Cells and the Tumor Microenvironment 4763 673 5728 324 2932 PMC10533046__F3 Recent Advances in the Biosynthesis of Natural Sugar Substitutes in Yeast 3652 54658 59330 PMC10534826__F2 Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer 7054 5091 1311 1431 2744 PMC10538272__F5 Irreversible repolarization of tumour‐associated macrophages by low‐Pi stress inhibits the progression of hepatocellular carcinoma 4615 4513 1236 7124 920 6361 PMC10540332__F7 Combined transcriptomic and metabolomic analysis of alginate oligosaccharides alleviating salt stress in rice seedlings 5182 51056 5184 PMC7614835__S1 Purine Biosynthetic Pathway, the Pathway Transforms PRPP (Phosphoribosyl Pyrophosphate) into IMP (Inosine Monophosphate) in 10 Biosynthetic Stepsa 435 5471 7808 PMC8595768__F1 Insulin signaling 2932 3667 5163 2475 2885 PMC8595768__F3 Oxidative stress-induced damage of IDE and BVR-A is associated with development of brain insulin resistance 3416 2932 5163 2475 PMC8630058__F5 Metabolic pathway linking methane oxidation to selenate reduction by bacterial consortia 23531 189 3045 100187828 1431 2645 1636 6395 PMC8648894__F1 Signaling in the crowded cell 153129 6009 9675 2475 64798 2885 23531 761 5728 1956 5879 PMC8669714__F2 Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics 22863 9140 10533 9474 8408 83734 9776 60673 2475 PMC9103744__F6 Overexpression of Renin-B Induces Warburg-like Effects That Are Associated with Increased AKT/mTOR Signaling 780904 351 6395 55066 253260 PMC9126990__F1 Biochemical genesis of enzymatic and non-enzymatic post-translational modifications 2821 435 7086 875 4524 6651 47 355 3033 1962 2744 PMC9149100__F7 Figure 3.Effect of CDK4 and CDK6 inhibition upon tumour cell-intrinsic and -extrinsic signalling pathways 1019 1017 253260 2475 1021 7249 6009 PMC9618889__F6 Major pathways involved in macrophage polarization in cancer 6714 2885 301 5728 6774 PMC9619038__F1 Editorial: Sirtuins and brain homeostasis 3603 114548 23410 1786 22933 23411 PMC9619106__F7 Transcriptome analysis reveals the proline metabolic pathway and its potential regulation TF-hub genes in salt-stressed potato 4942 5625 58510 PMC9626029__F4 Bleeding Propensity in Waldenström Macroglobulinemia: Potential Causes and Evaluation 4049 7450 102 PMC9629042__F2 Ultrasensitive chemiluminescent neuraminidase probe for rapid screening and identification of small-molecules with antiviral activity against influenza A virus in mammalian cells 4149 4827 5447 PMC9630645__F3 Therapeutic applications and potential mechanisms of acupuncture in migraine: A literature review and perspectives 3371 7038 7442 7124 6697 PMC9632296__F5 T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy 940 920 1956 978 PMC9632461__F6 CA regulates the mitochondrial quality and enhances the vitality of LMSCs 55669 51024 65018 9927 PMC9634730__F1 Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment 4609 50943 7157 PMC9636824__F9 Loss of Brca1 and Trp53 in adult mouse mammary ductal epithelium results in development of hormone receptor-positive or hormone receptor-negative tumors, depending on inactivation of Rb family proteins 2475 595 1019 1021 5925 1017 2099 PMC9637487__F3 Conservation and divergence: Regulatory networks underlying reproductive branching in rice and maize 51526 667 6670 27161 6688 PMC9638134__F6 Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder 4049 4050 3458 613 126014 27040 6850 373 7010 2274 1540 1610 29760 5879 10379 472 7124 1513 100187907 PMC9639746__F1 Cancer immunotherapy strategies that target the cGAS-STING pathway 324 115004 8161 PMC9640632__F1 Probabilistic model checking of cancer metabolism 4118 11113 4827 PMC9640784__F2 Select mechanisms of HER2-targeted resistance 2475 1017 1019 1021 595 4585 960 PMC9646812__F4 Transcriptomic profiling analysis to identify genes associated with PA biosynthesis and insolubilization in the late stage of fruit development in C-PCNA persimmon 1431 217 5132 PMC9650488__F6 Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking 5328 9961 7045 7216 367 581 5970 5447 3725 64853 PMC9654658__F3 Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response 4342 355 23237 266710 444 PMC9657932__F6 Enhancing an Oxidative “Trojan Horse” Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside 3845 2597 2242 PMC9659945__F2 Progress of protein synthesis factors eIFs, eEFs and eRFs in inflammatory bowel disease and colorectal cancer pathogenesis 4609 2475 1938 PMC9662279__F5 SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases 4520 51548 6502 7124 10135 5970 7226 PMC9662279__F7 SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases 51548 5966 4088 2297 9140 2475 6009 6667 2626 PMC9664868__F1 Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library 79717 60490 5471 PMC9670202__F2 When the clock ticks wrong with COVID‐19 59272 7113 406 PMC9671658__F8 Glis1 and oxaloacetate in nucleus pulposus stromal cell somatic reprogramming and survival 7086 2539 2597 5091 3948 5315 1737 5053 PMC9676466__F6 Whole genome analysis for plant growth promotion profiling of Pantoea agglomerans CPHN2, a non-rhizobial nodule endophyte 4151 7054 133418 4117 100 PMC9680067__F3 Teleost NOD-like receptors and their downstream signaling pathways: A brief review 10392 64127 3661 3665 57506 PMC9684343__F7 CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor 5091 3418 2194 3417 PMC9684732__F4 Endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy 7038 7186 7494 468 22926 1998 9618 PMC9685446__F9 Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis 23411 2194 7038 PMC9686704__F1 Research Progress on Mitochondrial Dysfunction in Diabetic Retinopathy 387 3383 2597 367 PMC9687165__F3 Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways 1436 23411 9935 84890 9314 6778 3717 PMC9687381__F2 Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation 367 22926 10682 7494 PMC9687450__F5 UPLC-QTOF/MS Metabolomics and Biochemical Assays Reveal Changes in Hepatic Nutrition and Energy Metabolism during Sexual Maturation in Female Rainbow Trout (Oncorhynchus mykiss) 7038 5091 638 PMC9687473__F1 Targeting Adiponectin in Breast Cancer 355 581 595 PMC9687800__F1 Emerging Role of YAP and the Hippo Pathway in Prostate Cancer 9686 4485 60485 9113 PMC9693457__F1 Old and New Facts and Speculations on the Role of the B Cell Receptor in the Origin of Chronic Lymphocytic Leukemia 695 5336 6850 2475 PMC9693569__F1 Polyphenols for Livestock Feed: Sustainable Perspectives for Animal Husbandry? 3652 10692 4974 PMC9694773__F1 The Pathogenesis of Acute Porphyria Attacks and Increasing Hepatic PBGD as an Etiological Treatment 210 130749 2271 7389 7390 PMC9696306__F6 Screening for Hyperthermophilic Electrotrophs for the Microbial Electrosynthesis of Organic Compounds 2271 4548 3045 100187828 65985 4311 PMC9700084__F1 Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury 4803 7099 595 847 PMC9701047__F6 Comparative transcriptomic analysis provides insights into the molecular basis underlying pre-harvest sprouting in rice 2597 1431 1743 PMC9708627__F2 Interferon in systemic lupus erythematosus—A halfway between monogenic autoinflammatory and autoimmune disease 11277 5132 920 PMC9708732__F3 Microglia autophagy in ischemic stroke: A double-edged sword 7099 8408 664 9776 7186 9474 9140 114548 PMC9709458__F1 T cell function by protein S-acylation 355 920 1445 2534 27040 2885 5335 324 6786 PMC9710321__F2 Cannabis sativa and Cannabidiol: A Therapeutic Strategy for the Treatment of Neurodegenerative Diseases? 2932 324 7442 PMC10137778__F8 Whole Transcriptome Analysis of Differentially Expressed Genes in Cultured Nile Tilapia (O. niloticus) Subjected to Chronic Stress Reveals Signaling Pathways Associated with Depressed Growth 6262 3270 845 PMC10142983__F6 Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2 3992 2717 9415 PMC10308667__F2 Comprehensive insight into the correlation between ncRNAs and the Wnt/Beta-catenin signalling pathway in gastric cancer pathogenesis 22943 2932 85407 324 1499 PMC10374606__F8 Prx II knock-down HaCaT cells are sensitive to H2O2 stimulation 57716 2932 317 PMC10375937__F13 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway 7099 4615 51135 7189 PMC10375937__F14 Cardioprotective effects of arjunolic acid in LPS-stimulated H9C2 and C2C12 myotubes via the My88-dependent TLR4 signaling pathway 7099 4615 51135 7189 PMC10376142__F1 Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms 84168 5045 100187761 PMC10377897__F3 KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review 9314 7018 4851 PMC10378342__F2 Intravenous Immunoglobulin in Kawasaki Disease—Evolution and Pathogenic Mechanisms 7188 114548 3553 3606 PMC10380727__F2 Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect 7225 729 8788 1499 4087 4088 PMC10384750__F2 Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer 2475 253260 64223 PMC10474053__F6 Ca2+-mediated inhibition of membrane localization of PIP-binding proteins 90550 5350 2932 7248 7249 PMC10474743__F4 Advances in immunotherapy for triple-negative breast cancer 115004 4582 1493 PMC10525295__F1 Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle Cell Anaemia 6319 2271 718 PMC10526236__F4 MicroRNAs in the Regulation of RIG-I-like Receptor Signaling Pathway: Possible Strategy for Viral Infection and Cancer 7706 63891 574442 7189 57506 3661 3665 PMC10526380__F3 Molecular Classifiers in Skin Cancers: Challenges and Promises 7157 2475 51684 5727 4609 PMC10528086__F1 When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex 4041 4040 1499 324 PMC10528955__F1 Neuroinflammation: A Modifiable Pathway Linking Obesity, Alzheimer’s disease, and Depression 7038 3553 7099 PMC10531892__F9 Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients 811 29108 114548 2597 PMC10534731__F2 Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review 4615 50507 3091 PMC9221318__F3 Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction 6608 2736 2737 PMC9250635__F1 CGAS activation and cGAS-STING signaling 115004 29110 3661 PMC9488848__F2 Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease 2885 5728 2475 PMC9629566__F3 Niloticin binds to MD-2 to promote anti-inflammatory pathway activation in macrophage cells 7099 4615 29949 PMC9629604__F1 IFN activation of the JAK-STAT signaling pathway 6772 367 6773 3458 9365 PMC9673322__F7 Inhibition of platelet activation suppresses reactive enteric glia and mitigates intestinal barrier dysfunction during sepsis 958 3553 7189 PMC9684870__F3 Disease-specific tissue glycosylation 10585 6347 324 PMC9699629__F3 Immunomodulatory Role of Thioredoxin Interacting Protein in Cancer’s Impediments: Current Understanding and Therapeutic Implications 6945 2475 3777 10628 6774 PMC9700203__F7 Chromosome-level genome assembly for Dracaena cochinchinensis reveals the molecular basis of its longevity and formation of dragon’s blood 57716 847 4602 PMC9877271__F1 Unfolded protein response and ER-associated degradation under freezing, anoxia, and dehydration stresses in the freeze-tolerant wood frogs 22926 468 467 PMC10152798__F5 HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway 7474 54361 7481 PMC10242860__F4 Ferritin in cancer therapy: A pleiotropic tumoraffin nanocage‐based transport 29110 54106 3661 PMC10473922__F9 Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NFKB pathway 23411 948 355 PMC10520882__F7 Biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype 84254 10645 2475 PMC10536258__F2 Brain pericyte biology: from physiopathological mechanisms to potential therapeutic applications in ischemic stroke 1267 2863 2475 PMC9653095__F3 NAD+ synthesis from the de novo, Preiss-Handler and Salvage pathways 4827 93100 23475 PMC9661468__F4 Stress during mitosis activates apoptosis and inflammation 115004 4193 3661 PMC9710037__F2 Mathematical model of the cell signaling pathway based on the extended Boolean network model with a stochastic process 1956 2064 2885 PMC9923939__F1 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 930 1956 581 595 5728 5163 PMC9923939__F2 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 7124 929 8717 7186 4615 7189 331 PMC9923939__F5 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 7039 367 1950 1956 2549 6714 581 6774 5728 572 2932 2475 PMC9923939__F3 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 7124 5894 355 8717 1616 7186 PMC9923939__F6 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 355 4193 1017 1021 1019 581 PMC9923939__F8 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 2932 5728 5163 7248 51256 64798 PMC9923939__F9 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 3549 50846 6469 5727 6608 2736 2737 2735 147040 4609 PMC9923939__F4 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 25805 324 1499 595 4316 PMC9923939__F7 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action 4838 4090 4086 4088 4087 4091 4092 4089 4434 PMC9902738__F2 Potential benefits of cinnamon to patients with diabetes, obesity, or CVDs 5465 7350 8989 948 PMC9935926__F3 Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions 1499 6774 2475 5728 6741 PMC9935926__F7 Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions 283871 10562 664 7039 1956 PMC9934381__F11 Model of cGAS-mediated antiviral function in EV-A71, SVV, and FMDV replication 115004 29110 3661 PMC10280140__F11 TGF‐B‐induced PI3K/AKT/mTOR pathway 4318 7046 7048 64422 9474 10533 3667 2475 PMC9713001__F2 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma 100653366 8140 3098 3099 6510 2673 3939 2805 2806 2744 PMC9713001__F4 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma 3845 4089 6774 2475 23657 6520 8408 2879 10533 64422 PMC9713001__F6 Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma 406983 5728 27250 3200 7077 100422909 407006 442920 6935 7428 7022 9839 9021 8651 3198 406992 406913 6774 4087 6772 693122 4089 9306 442918 7048 1051 2308 3726 857 664 7350 PMC9755959__F8 MiR-378a-3p acts as a tumor suppressor in gastric cancer via directly targeting RAB31 and inhibiting the Hedgehog pathway proteins GLI1/2 6608 6469 11031 51684 2736 2735 5727 PMC9901261__F1 Emerging role of triggering receptor expressed on myeloid cell-2 in malignant tumor 102 6868 6850 6714 PMC9943254__F2 Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment 2194 5132 3418 3417 2271 23476 2744 4609 6510 8140 PMC9943254__F8 Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment 6608 6469 51684 2735 5727 PMC9929940__F5 Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern 912 941 940 942 3458 613 1236 6361 920 958 29851 643 PMC9942973__F9 Working model for HCMV-induced SOCS3 upregulation in NPCs 9021 64864 3976 PMC10273736__F2 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies 27040 613 6850 29760 4615 7189 472 331 1540 10913 7187 7706 4513 3929 929 114609 51135 3654 7099 1270 4803 1950 7186 4049 4050 PMC10273736__F3 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies 2002 6722 3727 3240 7124 8717 355 4615 929 1616 23118 51295 4149 994 51701 PMC10273736__F5 Review of Duhuo Jisheng decoction mechanisms in intervertebral disc degeneration in vitro and animal studies 7054 7124 4513 PMC10275075__F5 Population response of intestinal microbiota to acute Vibrio alginolyticus infection in half-smooth tongue sole (Cynoglossus semilaevis) 4397 2313 55137 PMC10657592__F1 Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering 4089 4087 4088 4092 7189 2885 5879 1950 4018 PMC10722483__F6 Acupoint catgut embedding attenuates fibromyalgia pain through attenuation of TRPV1 signaling pathway in mouse 7442 1636 2475 PMC10750275__F1 YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer 6010 4771 4485 60485 5784 9113 26524 PMC10750275__F7 YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer 6498 114004396 3146 9474 5728 PMC10750282__F2 CGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention 7099 7098 7186 115004 29110 3661 5140 6347 7412 3383 4318 6833 5080 4485 9113 79792 217 11326 PMC10750282__F3 CGAS-STING Signalling in Metabolic Diseases: from Signalling Networks to Targeted Intervention 7099 7187 4615 7189 29110 114548 9447 8878 115004 3661 3667 8408 2475 3455 3454 PMC10750283__F4 Nuclear Receptors in the Pathogenesis and Treatment of Non-alcoholic Fatty Liver Disease 2264 9965 5465 23175 84649 1581 PMC10750287__F4 Cross-Communication of Cuproptosis and Regulated Cell Death in Human Pathophysiology 79792 836 841 834 58484 114548 PMC10750291__F4 Biological mechanism and emerging therapeutic interventions of liver aging 8717 8195 4149 51701 1386 PMC10750291__F5 Biological mechanism and emerging therapeutic interventions of liver aging 7097 54472 4615 114609 3929 929 8195 7189 3663 958 941 5132 51135 1513 54106 7187 3661 8772 100187907 1616 790 468 9049 4703 367 PMC10750291__F6 Biological mechanism and emerging therapeutic interventions of liver aging 920 6886 8717 8772 100187907 6280 3934 6278 7054 546 1663 114799 157570 9126 5885 23383 23063 983 1874 4088 4087 4089 10403 4193 6502 4609 9319 9184 324 991 5111 993 1021 1019 1017 1022 90381 27085 990 8317 10926 999 PMC10751671__F1 Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research 7422 7412 3479 2475 PMC10751671__F2 Impact of Physical Exercise on Melanoma Hallmarks: Current Status of Preclinical and Clinical Research 581 3481 3479 6774 940 3458 PMC10751873__F5 CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers 643911 6431 1871 8301 5906 PMC10754983__F7 Current insight on the mechanisms of programmed cell death in sepsis-induced myocardial dysfunction 5728 2475 8408 PMC10755185__F6 Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes 3426 102 581 351 2056 57085 10135 PMC10755271__F6 Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf 226 5747 5894 383 1509 5604 2353 3326 3479 3717 6772 3055 1991 3265 5599 7422 5781 3718 5594 387 54331 4790 4846 207 2033 3725 6714 3558 2782 5879 3932 4318 2885 3486 6850 5340 3791 695 2147 2247 1956 3569 2099 5170 367 7124 PMC10755469__F2 Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury 114548 4353 79792 2539 2821 115004 PMC10755684__F2 Neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance 1435 1440 4922 PMC10755915__F6 Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism 9332 4481 9314 19 5468 5004 948 4495 1593 4496 PMC10756743__F6 Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation 961 9509 4035 7058 92949 3688 81792 4313 11096 PMC10757365__F3 Immune checkpoints in antitumor response: a potential antitumor immunotherapy 940 941 942 3717 3716 6772 324 3659 PMC10757641__F1 G protein-coupled receptors and obesity 4160 181 2693 23237 2740 2642 5443 2696 4922 5697 2695 PMC10757967__F2 Advances in the regulatory mechanisms of mTOR in necroptosis 8717 7186 8737 1540 23118 90268 7098 8772 841 11035 7099 100187761 81030 197259 9365 355 PMC10757967__F3 Advances in the regulatory mechanisms of mTOR in necroptosis 8717 7186 8737 8772 841 11035 2475 197259 PMC10758279__F2 In Vitro and In Vivo Analysis of Neurotrophin-3 Activation of Arf6 and Rac-1 627 7074 160622 382 PMC10758458__F1 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer 1956 2885 5728 4193 572 2475 7249 7248 1977 PMC10758458__F2 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer 9817 4363 1244 10257 10057 9429 PMC10758458__F3 Advances in the role of microRNAs associated with the PI3K/AKT signaling pathway in lung cancer 407009 5728 100616135 7157 23035 23239 2308 10659 3399 5879 100423026 554212 406929 PMC10758489__F1 Metabolic reprogramming in the tumor microenvironment: unleashing T cell stemness for enhanced cancer immunotherapy 4548 635 2475 PMC10758851__F1 Development and Clinical Applications of PI3K/AKT/mTOR Pathway Inhibitors as a Therapeutic Option for Leukemias 613 5728 7248 7249 1147 6009 64798 253260 64223 9675 4193 PMC10758887__F16 Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives 22943 4041 4040 324 1499 PMC10758965__F2 Regulatory mechanisms of one-carbon metabolism enzymes 1869 2305 4904 468 4609 26227 29968 1719 5723 7298 6472 6470 4524 4548 441024 160428 4522 25902 PMC10758965__F3 Regulatory mechanisms of one-carbon metabolism enzymes 4088 4609 468 467 23081 PMC10758965__F5 Regulatory mechanisms of one-carbon metabolism enzymes 5631 6470 6472 5471 4522 441024 2618 25902 7808 1719 7298 10606 158 5111 471 10588 PMC10759256__F1 DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells 2729 2730 2937 PMC10759355__F1 Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability 4615 7099 175 PMC10759521__F9 DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma 8451 1642 25879 9978 355 581 1026 PMC10759702__F7 Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy 3458 3569 3553 7124 7098 1051 6774 3725 6667 4790 1050 PMC10759737__F6 RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding 2475 57521 7528 56848 6774 PMC10760828__F9 Schematic representation of overall outcome of the study 5371 6672 1616 PMC10761042__F8 PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway 1018 898 983 PMC10933535__F1 Metabolic reprogramming and signalling cross-talks in tumour–immune interaction: a system-level exploration 1950 2064 3458 355 941 324 7186 8717 7054 100188776 5728 7249 6361 6367 7124 8139 920 3566 1233 8651 7535 50943 PMC10991369__F6 Comparative transcriptome analysis of Trichoderma reesei reveals different gene regulatory networks induced by synthetic mixtures of glucose and Beta-disaccharide 7095 100187907 258010 6396 22926 PMC10991915__F4 Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation 5183 4118 6120 5132 11113 PMC10991944__F1 Metabolic engineering of methylotrophic Pichia pastoris for the production of Beta-alanine 11113 554235 4118 443 PMC10992393__F1 De novo synthesis of nervonic acid and optimization of metabolic regulation by Yarrowia lipolytica 355 26136 11113 3067 PMC10992410__F2 Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast 2078 2022 60672 85569 PMC10993494__F9 Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development 57104 948 2099 1906 3553 3952 3569 4314 887 3479 4023 4353 834 3458 5468 5045 2494 5879 10094 8772 5241 6256 51129 998 6667 6720 7040 2194 79071 7157 5366 3992 5376 3576 1523 3638 1051 2252 6351 10858 3635 2308 5514 4615 93974 1050 5155 9370 133 92335 32 5295 80339 92691 84196 4843 51351 7124 5743 PMC11003747__SF3_1 I-ASD p-proteome network analysis 23022 9967 27316 8661 10763 6194 23524 51755 55660 4904 23476 124245 64223 6660 58517 6599 PMC11003747__SF3_2 I6pDel p-proteome network analysis 6601 4678 1978 100101267 4686 8661 5073 23215 50810 1975 113251 9324 PMC11003748__F1 Matrix-derived coupling factors 7480 649 2475 3479 58191 PMC11003766__F5 The BTN2A1-BTN3A1-BTN3A2 complex regulation 11119 11120 11118 11079 84166 3659 7764 1487 861 2242 717 718 57128 9054 27247 23479 2395 2230 2232 22 4682 51218 3313 26502 9391 150274 84920 79053 29880 9526 29929 79087 8813 8818 54344 79796 10195 10020 201595 1603 3703 1650 6184 6185 7991 23193 7841 11253 79644 79868 1798 22845 57171 56052 91869 54187 140838 55907 29926 29925 2821 4121 10905 4245 4124 4122 57134 4351 5373 4248 4247 11320 25834 146664 4249 11282 152586 6480 84620 2683 8704 8703 10559 PMC11003953__F2 Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic 2668 627 5697 7040 PMC11004224__F5 PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study 5360 4023 4312 3611 7316 PMC11004224__F7 PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study 7099 3458 7428 2056 7018 5163 2597 226 3939 PMC11004261__F3 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions 1809 2146 2932 PMC11004261__F5 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions 6774 81029 7474 7481 6714 2475 898 595 1019 2353 3725 596 598 836 PMC11004450__F1 Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells 2821 64841 5238 55577 6675 8473 10724 PMC11004450__F6 Single cell and bulk RNA expression analyses identify enhanced hexosamine biosynthetic pathway and O-GlcNAcylation in acute myeloid leukemia blasts and stem cells 55577 64841 5238 6675 8473 10724 PMC11004819__F3 Pharmacogenomics-based systematic review of coronary artery disease based on personalized medicine procedure 2222 3156 64240 64241 6713 84532 1581 3949 4035 4023 3990 6646 8694 64714 4547 949 1071 5360 3931 19 344 341 345 338 116519 337 407039 693120 PMC11004986__F8 Autotaxin and lysophosphatidic acid deficiencies on depression-like behaviors in mice exposed to chronic unpredictable mild stress 4018 6855 627 PMC11005288__F5 Compound Shenma Jingfu granule alleviates cerebral ischemia via HIF-1Alpha-mediated promotion of angiogenesis 7099 7975 6194 2475 1610 7428 8453 2056 7018 7037 5163 2597 226 3939 PMC11005958__F1 Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo 9510 324 5764 1499 325 4627 PMC11006482__F9 Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice 23411 114548 7124 3032 PMC11007064__F6 Enhanced GATA4 expression in senescent systemic lupus erythematosus monocytes promotes high levels of IFNA production 1029 115004 3661 2626 PMC11007101__F2 Therapeutic prospects of nectin-4 in cancer: applications and value 207 6868 6714 PMC11007187__F1 Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies 192670 27161 26523 192669 5901 29102 PMC11007187__F4 Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies 627 5728 2885 23411 2475 7249 7248 6009 PMC11008418__F8 Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis 23411 23657 2879 79792 6520 PMC11008420__F1 MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma 1950 3082 1956 100616283 2885 999 693235 5728 2475 406962 1000 595 9839 442901 407033 6935 PMC11008420__F2 MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma 960 999 7048 6774 4087 4088 324 1499 4089 1000 595 9839 6935 100422860 PMC11008464__F1 New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis 23408 2744 4199 4118 95 1373 162417 11113 2805 5009 339983 4942 445 383 435 PMC11008728__F2 Fine-tuning tumor- and allo-immunity: advances in the use of immune checkpoint inhibitors in kidney transplant recipients 3627 6373 4283 941 324 PMC11009036__F1 Nonsense-mediated RNA decay pathway 23049 65109 26019 4116 5976 9775 23381 23293 9887 PMC11009184__F7 Translatability of mouse muscle-aging for humans: the role of sex 4280 2475 10000 3667 208 5287 207 PMC11009220__F2 Interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health 59272 57506 3661 3665 51284 4615 7189 29110 PMC11009445__F1 Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review 6010 26524 9113 355 4485 PMC11010261__F1 YAP/TAZ‐TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma 4771 9231 60485 4485 9113 26524 3611 6714 55233 92597 29888 7005 8463 7004 7003 6010 PMC11010636__F2 Exploring the regulatory mechanism of intestinal flora based on PD-1 receptor/ligand targeted cancer immunotherapy 10803 2833 920 115004 64127 PMC11011055__F7 Targeting Siglec–Sialylated MUC1 Immune Axis in Cancer 10020 54187 51083 PMC11011199__F2 Prediction of Response to Anti-Angiogenic Treatment for Advanced Colorectal Cancer Patients: From Biological Factors to Functional Imaging 572 5728 6714 2885 5894 PMC11011407__F2 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies 2048 2475 2247 1969 2043 2260 5879 998 6237 PMC11011430__F6 Analysis of the Gene Networks and Pathways Correlated with Tissue Differentiation in Prostate Cancer 859 90550 5350 3270 10345 9241 613 1610 5266 PMC11011684__F3 Gene Expression Patterns Associated with Survival in Glioblastoma 11197 3486 4804 4088 4089 5335 1278 6010 2475 5578 1499 1956 4904 2033 PMC11011857__F3 Genetic Signature of Human Pancreatic Cancer and Personalized Targeting 1950 1956 3845 2475 PMC11011983__F1 Alterations in Proteostasis Mechanisms in Niemann–Pick Type C Disease 4864 11337 64225 PMC11012149__F2 Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease 9049 790 355 3480 3064 3146 7099 22861 114548 9447 58484 8717 8772 197259 3182 4082 PMC11012151__F2 Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism 5728 572 65018 PMC11012151__F7 Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism 284207 145957 7019 PMC11012155__F1 Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer 196 9049 1543 405 1545 1316 PMC11012292__F1 Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet 635 1103 43 4524 4397 10400 PMC11012314__F7 Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis 3091 54583 112398 112399 2271 405 1387 2033 7428 9978 6921 8453 6923 5546 7030 1026 81578 7942 1513 253559 6513 7422 7040 5155 7039 1856 1729 7042 79444 7043 1950 PMC11012409__F1 Agnostic Administration of Targeted Anticancer Drugs: Looking for a Balance between Hype and Caution 673 4915 4916 4914 5979 672 PMC11012486__F1 Identification of PTPN12 Phosphatase as a Novel Negative Regulator of Hippo Pathway Effectors YAP/TAZ in Breast Cancer 11059 83737 154796 558 79633 4485 9113 26524 5784 11099 6010 4018 PMC11012558__F3 Calcium and Neural Stem Cell Proliferation 57113 7225 7222 7223 7220 2260 80228 84876 6786 PMC11012607__F4 Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review 3383 7124 54898 60481 83401 64834 PMC11012648__F1 Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways 960 218 220 4072 216 1604 79923 7852 6657 2735 1499 217 6608 PMC11012648__F3 Informed by Cancer Stem Cells of Solid Tumors: Advances in Treatments Targeting Tumor-Promoting Factors and Pathways 64840 84133 54894 324 1499 PMC11012680__F2 Synthetic Routes and Clinical Application of Representative Small-Molecule EGFR Inhibitors for Cancer Therapy 1956 2549 2885 6714 PMC11012756__F5 Therapeutic Advances and Challenges for the Management of HPV-Associated Oropharyngeal Cancer 1019 673 6790 7465 2195 1499 5728 2475 55294 4193 5347 5300 PMC11013731__F6 Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NFKB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice 7099 85451 6395 PMC11014460__F1 Responses of HIFs to hypoxia or hyperoxia 7428 2056 5230 PMC11014885__F4 Endosymbiont Tremblaya phenacola influences the reproduction of cotton mealybugs by regulating the mechanistic target of rapamycin pathway 6821 10380 23474 PMC11015223__F9 OMA1 competitively binds to HSPA9 to promote mitophagy and activate the cGAS–STING pathway to mediate GBM immune escape 3002 115209 3313 7416 665 664 PMC11015399__F1 Hippo signalling pathway and its impact on eye diseases 4771 6010 4485 5817 PMC11015576__F8 PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer 3146 80243 29110 115004 3661 PMC11015656__F1 Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review 1956 1950 6714 3082 5728 6010 3091 3417 64798 4255 PMC11016017__F3 Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling 472 545 581 51135 4513 51548 960 100133941 79923 1956 7124 2475 6657 64754 PMC11016256__F2 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis 3655 5728 5163 5164 4087 PMC11016256__F3 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis 5970 5971 3146 PMC11016256__F4 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis 3655 5728 8091 4088 6608 4969 3146 PMC11016262__F2 Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis 920 10392 64127 PMC11016524__F2 Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example 717 1443 5728 7249 7248 PMC11016731__F3 Rationale for immune checkpoint inhibitors plus targeted therapy for advanced renal cell carcinoma 2475 7428 9242 324 940 7535 PMC11016796__F2 Proteomic analyses on chicken breast meat with white striping myopathy 7157 9532 1026 65018 5071 4193 PMC11016919__F1 Trimetazidine May Potentially Confer Neuroprotective Effects against COVID-19-Induced Neurological Sequelae via Inhibition of Death-Associated Protein Kinase 1 (DAPK1) Signaling Pathways: An Evidenced-Based Hypothesis 5728 627 581 PMC11017435__F1 NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease 581 355 8717 8772 637 PMC11018134__F7 FBL Promotes LPS-Induced Neuroinflammation by Activating the NFKB Signaling Pathway 929 4615 2091 PMC11018843__F1 Main cytosolic DNA sensors and their downstream pathways 115004 9632 26100 9474 51428 695 9415 197259 3428 9447 81030 11035 8737 8772 29110 6778 3661 7186 3627 6352 6347 6364 10344 2475 PMC11018843__F3 Parkinson’s disease (PD) and cytosolic DNA sensors 65018 10452 115004 29110 3661 9447 3428 3454 PMC11018843__F4 Amyotrophic Lateral Sclerosis (ALS) and cytosolic DNA sensors 115004 51428 695 29110 6647 3661 203228 24145 PMC11019011__F5 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity 860 3569 4772 3606 22943 PMC11019012__F2 Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy 572 8772 637 581 331 PMC11019147__F4 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging 7189 5879 5335 4772 2932 PMC11019147__F1 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging 84876 5335 7189 4772 7187 PMC11019147__F3 Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging 7189 596 54790 10365 8408 664 PMC11019464__F2 Chemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review) 1499 55364 324 4041 4040 PMC11019495__F3 Recent advances of nanoparticles on bone tissue engineering and bone cells 651 860 100187907 650 PMC11019597__F3 Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review 4038 4314 4593 PMC11019653__F7 Effect of 23‑hydroxybetulinic acid on lung adenocarcinoma and its mechanism of action 5743 1636 4193 PMC11019719__F2 Exercise induction at expression immediate early gene (c-Fos, ARC, EGR-1) in the hippocampus: a systematic review 23411 627 6774 23237 1958 PMC11019835__F1 Canonical and non-canonical function of CD55 1950 1604 717 718 3932 2932 6774 1499 727 729 735 730 79923 672 6657 4292 4313 4609 4318 PMC11033207__F1 Redox signaling and skeletal muscle adaptation during aerobic exercise 6649 343 50507 6648 PMC11033207__F6 Redox signaling and skeletal muscle adaptation during aerobic exercise 6649 7124 2879 4050 847 8717 8772 4055 3418 23409 23410 23411 5970 4513 4094 5971 4504 6647 6648 PMC11033413__F2 Progress of medicinal plants and their active metabolites in ischemia-reperfusion injury of stroke: a novel therapeutic strategy based on regulation of crosstalk between mitophagy and ferroptosis 3156 4771 2744 3652 29923 2879 PMC11033433__F2 Research progress on radiation resistance of cervical cancer 92140 6927 596 5892 253943 4751 2033 7471 3149 23409 9325 PMC11033433__F4 Research progress on radiation resistance of cervical cancer 995 25818 891 472 147948 PMC11033467__F5 Immunomodulatory effects of a probiotic combination treatment to improve the survival of Pacific oyster (Crassostrea gigas) larvae against infection by Vibrio coralliilyticus 10333 7098 790 7128 4615 55366 8780 5716 7099 329 330 79444 PMC11033503__F2 C/EBPB: A transcription factor associated with the irreversible progression of Alzheimer's disease 2932 351 6418 627 6733 PMC11033503__F4 C/EBPB: A transcription factor associated with the irreversible progression of Alzheimer's disease 6786 7220 84876 PMC11034130__F2 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy 355 948 1493 50943 7086 5728 2308 7019 9453 2339 2342 3091 6775 22937 29851 PMC11034130__F3 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy 4023 948 50943 4609 940 3091 1493 5728 7428 6775 2308 163882 PMC11034130__F4 Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy 948 5728 2879 50943 970 939 1493 PMC11034170__F3 Updated mechanisms of MASLD pathogenesis 6520 55240 275 2879 619501 PMC11034608__F7 p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model 23657 2879 2512 6303 PMC11035622__F8 Mitochondrial enzyme FAHD1 reduces ROS in osteosarcoma 92014 4118 6576 5091 11113 2744 47 3240 PMC11035635__F2 Core molecular mechanisms of different types of RCD and the potential CAF-derived molecules that regulate RCD 8408 9776 55626 60673 22863 2475 100506068 283120 3082 3146 6387 3606 1723 2643 2879 79792 PMC11035723__F1 Early dynamic changes to monocytes following major surgery are associated with subsequent infections 942 941 729230 1233 1493 940 3575 PMC11036006__F13 Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation 5266 5163 581 PMC11036065__F2 Molecular targeted therapies for cutaneous squamous cell carcinoma: recent developments and clinical implications 4041 847 6009 7008 PMC11036351__F1 Hyper-Responsive Chemiluminescent Probe Reveals Distinct PYRase Activity in Pseudomonas aeruginosa 4827 4151 51083 PMC11036658__F9 Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer 581 2475 983 PMC11036733__F6 Dengue virus pathogenesis and host molecular machineries 140691 115004 716 6773 PMC11037034__F3 Novel milestones for early esophageal carcinoma: From bench to bed 9235 4615 7099 4087 PMC11037416__F2 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages 140609 79792 7099 8737 8717 7186 8767 8772 197259 11035 PMC11037416__F1 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages 100 7018 121549 2744 2937 2879 10162 2475 9776 60673 8408 9706 9140 9474 83734 10533 64422 PMC11039397__GA1 StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NFKB/p-ERK MAPK-NFATc1 signaling pathway 9049 196 405 1513 4772 54 81501 245972 PMC11039815__F1 Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions 115004 6573 4363 29110 3661 PMC11039848__F2 How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography? 1581 1593 1582 9420 570 PMC11039990__F7 Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis 4881 9118 7018 PMC11039994__F8 Levels of p53 govern the hierarchy of DNA damage tolerance pathway usage 84083 5111 6596 51455 11201 27343 353497 201973 27445 PMC11040167__F6 Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells 4094 545 9817 PMC11040290__F1 Emerging role of galectin 3 in neuroinflammation and neurodegeneration 960 3459 3611 10461 3479 PMC11040299__F1 Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer's disease 7124 8717 8772 8737 11035 197259 PMC11040350__F1 Platelet Membrane Nanocarriers Cascade Targeting Delivery System to Improve Myocardial Remodeling Post Myocardial Ischemia–Reperfusion Injury 6774 7124 383 29949 PMC11040904__F5 Emerging therapeutic frontiers in cancer: insights into posttranslational modifications of PD-1/PD-L1 and regulatory pathways 3703 83590 2683 144423 1499 324 10331 1950 23480 79633 79623 2590 PMC11042021__F7 KEGG pathway diagram for graft-vs.-host disease depicting the complex interplay of cellular and molecular interactions involved in the pathogenesis of graft-vs.-host disease (GVHD) 940 324 920 7124 3002 PMC11042021__F8 KEGG pathway diagram for antigen processing and presentation illustrating the central processes involved in antigen processing and presentation, which are essential for immune system function 3458 6890 6891 821 6892 811 567 1508 920 PMC11042502__F2 Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD 1376 1374 948 37 33 34 35 28976 3030 1892 3032 10449 PMC11042538__F2 Cellular senescence in cancer: molecular mechanisms and therapeutic targets 10873 25842 7290 472 545 4312 115004 3661 7124 6774 3717 2475 2626 1051 PMC11165723__F3 Journey of a generation: advances and promises in the study of primordial germ cell migration 387 5879 6387 7852 4026 23303 6714 4920 3815 PMC11202107__F1 Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis 7908 2625 9021 6778 9655 6775 3566 3716 3717 3718 7297 3569 6774 PMC11208122__F12 Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3B signaling pathway 3716 5163 930 581 PMC11210699__F2 Therapeutic effects of baicalin and baicalein 7099 2475 1499 890 1017 8408 581 PMC11211395__F2 Dual role of sirtuins in cancer: biological functions and implications 4609 51548 6210 7037 5163 6648 23410 23409 PMC11211395__F3 Dual role of sirtuins in cancer: biological functions and implications 51548 142 6996 581 7486 545 23411 7507 PMC11211608__F2 Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes 387 9344 8452 253980 9961 PMC11211685__F4 Fusarium mycotoxins: The major food contaminants 6935 9839 7216 6955 7263 PMC11211685__F5 Fusarium mycotoxins: The major food contaminants 7124 100653365 5728 PMC11212332__F7 Characterisation of sRNAs enriched in outer membrane vesicles of pathogenic Flavobacterium psychrophilum causing Bacterial Cold Water Disease in rainbow trout 8411 8651 9021 PMC11212664__F8 Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis 4615 10392 64127 PMC11212700__F1 From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders 79594 25820 29110 65018 10133 11331 665 664 192111 139341 6714 PMC11212700__F2 From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders 11245 4485 2778 665 664 2686 9927 23411 54106 3164 114548 65018 8408 PMC11213636__F7 Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGFB/Smad Signaling Pathway 4087 4088 4089 PMC11214299__F3 Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia 867 6478 25801 8216 90678 55294 8445 7189 4609 6502 8408 5728 7874 29761 9100 5371 8239 9098 9958 55031 PMC11214488__F8 GSK2334470 attenuates high salt-exacerbated rheumatoid arthritis progression by restoring Th17/Treg homeostasis 5170 6446 3939 3099 920 PMC11214942__F4 Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions 581 5163 572 PMC11214942__F5 Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions 6714 4485 387 1398 5879 9780 PMC11215092__F1 Molecular pathways and targeted therapies in head and neck cancers pathogenesis 1956 4041 4040 2885 5728 8312 8313 6774 1499 2475 55294 4485 4609 3725 55841 9113 2033 1387 PMC11215396__F1 CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis 811 4352 2057 PMC11215460__F1 Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway 5318 362 360 1499 PMC11215755__F1 PI3K pathway in non-malignant cells and cancer 5728 5170 7249 7248 6009 PMC11215755__F3 Signalling and epigenetic mechanisms limiting the efficacy of PI3K inhibitors 8821 5266 5170 5728 8085 1019 1021 595 672 PMC11216096__F1 Wnt signaling in gastric cancer: current progress and future prospects 999 324 5879 387 85451 1499 PMC9715766__F2 Gut microbiota, pathogenic proteins and neurodegenerative diseases 7099 10333 114548 54209 4615 115004 100187761 PMC9755961__F3 Heterogeneity of neutrophils in cancer: one size does not fit all 7226 3082 942 920 383 140885 961 PMC9843445__F3 Major roles of the circadian clock in cancer 2475 9575 218 4613 PMC9843448__F1 Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies 6774 619501 7422 4513 26471 6659 2247 5154 6387 2260 7852 4090 4086 PMC9923233__F7 Screening for diagnostic targets in tuberculosis and study on its pathogenic mechanism based on mRNA sequencing technology and miRNA-mRNA-pathway regulatory network 7707 7398 7273 57646 7704 7337 7157 7508 3113 9135 26052 29126 1950 8936 868 28964 375 389 207 26003 817 26999 6396 23191 7841 11276 6845 PMC9926763__F8 Sirtuin 3 regulation: a target to alleviate Beta-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells 23410 4703 355 4312 2475 8408 PMC9926998__F8 Ozonated Water Inhibits Hepatocellular Carcinoma Invasion and Metastasis by Regulating the HMGB1/NFKB/STAT3 Signaling Pathway 4313 4318 3146 PMC9927011__F1 Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer 6774 3002 2919 2920 6374 3596 8205 PMC9927011__F2 Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer 115004 1493 941 PMC9928209__F2 Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug 2475 3146 1017 1021 1019 5640 581 PMC9928209__F7 Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug 5728 2475 51083 1977 1975 PMC9928999__F2 Regulatory effects of oral microbe on intestinal microbiota and the illness 7082 7097 7099 6364 6280 PMC9929207__F4 MAPKAPK2-centric transcriptome profiling reveals its major role in governing molecular crosstalk of IGFBP2, MUC4, and PRKAR2B during HNSCC pathogenesis 1994 7538 9261 4117 PMC9929508__F3 Microgravity and immune cells 3385 6955 545 472 942 941 940 PMC9929774__F5 Bioinformatics analysis of differentially expressed genes in diabetic foot ulcer and preliminary experimental verification 51701 6502 4485 664 3479 5728 3630 3643 472 7874 10365 PMC9931120__F11 The working model of how FMDV infection regulates host amino acid metabolism 7249 146167 6009 2475 PMC9932084__F10 Work model of 181-Rik function in the mitochondria-mediated inflammatory response of microglia 647087 7351 114548 834 79792 PMC9935929__F5 Signaling pathways in rheumatoid arthritis: implications for targeted therapy 6850 5879 89797 695 2475 2932 3091 1499 1386 PMC9949365__F1 Orthogonal Functional Genomic and Proteomic Analyses Nominate AKT Activation as an Actionable Consequence of Selinexor Treatment 7514 23533 2475 5170 10000 208 253260 5294 79109 5728 339855 64798 2932 7249 7248 5347 8772 PMC10276824__GA FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury 920 2308 619501 PMC10305623__F1 11-oxygenated androgens in prostate cancer 6716 5091 367 8644 3294 3283 1646 8630 PMC10511167__F7 MiR-143/145 cluster induced by TGFB1 suppresses Wilms’ tumor 1 expression in cultured human podocytes 4087 4089 7490 PMC10551140__F7 Sestrin2 protects against hypoxic nerve injury by regulating mitophagy through SESN2/AMPK pathway 2475 665 664 79671 PMC10750202__F2 Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation 4041 4040 10454 8195 324 1499 57154 64750 860 1749 9759 10014 PMC10750205__F2 Endosialin in Cancer: Expression Patterns, Mechanistic Insights, and Therapeutic Approaches 161198 79812 5054 PMC10750294__F8 MANF Promotes Unexplained Recurrent Miscarriages by Interacting with NPM1 and Downregulating Trophoblast Cell Migration and Invasion 7873 4869 4313 5111 4318 PMC10751868__F5 H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer 3181 283120 6615 PMC10751872__F3 Advances in Regulating Cellular Behavior Using Micropatterns 650 9113 26524 PMC10751873__F4 CRNDE: A Pivotal Oncogenic Long Non-Coding RNA in Cancers 643911 100422996 1499 1021 1019 898 891 PMC10756743__F5 Transcription Analysis of the THBS2 Gene through Regulation by Potential Noncoding Diagnostic Biomarkers and Oncogenes of Gastric Cancer in the ECM-Receptor Interaction Signaling Pathway: Integrated System Biology and Experimental Investigation 9383 101929623 7058 PMC10757071__F5 Significance of long non-coding RNAs in the pathogenesis, diagnosis and treatment of inflammatory bowel disease 7099 7133 2146 3939 7040 PMC10758544__F9 Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NFKB signaling pathway 1513 4772 4318 PMC10758606__F1 NFKB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells 958 5971 5970 PMC10759449__F8 Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway 9601 8887 581 PMC10915323__F1 Leveraging molecular targeted drugs and immune checkpoint inhibitors treat advanced thyroid carcinoma to achieve thyroid carcinoma redifferentiation 3082 2668 1950 1956 5979 2322 2475 7173 PMC11003951__F8 Inflammatory Factor IL1A Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca2+/CaMK2b Pathway 3552 2905 816 PMC11003953__F3 Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic 627 9575 2865 2867 PMC11004261__F4 Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventions 4193 4613 331 PMC11005242__F7 GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway 6935 999 260431 PMC11005695__S1 Thermosensitive Bi‐Adjuvant Hydrogel Triggers Epitope Spreading to Promote the Anti‐Tumor Efficacy of Frameshift Neoantigens 115004 4810 51284 7189 29110 3665 3661 PMC11006730__F4 Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link? 8737 11035 387 PMC11006979__F2 Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies 4089 1024 1025 6772 PMC11007890__F5 Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma 6418 3066 3065 4316 2146 999 6774 2932 324 PMC11010095__F8 The pivotal role of CTRP9 in reendothelialization of EPCs and the protective mechanisms of AMPK‐mediated Akt/eNOS signaling involved in adipoR1 and N‐cadherin receptor 51094 1000 79602 PMC11011033__F3 NDRGs in Breast Cancer: A Review and In Silico Analysis 10397 1956 999 6446 PMC11011352__F1 Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway 29102 54487 389421 79727 23318 PMC11011407__F3 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies 2048 2047 4613 2050 1019 PMC11011407__F4 Clinical Relevance of the EPH/Ephrin Signaling Pathway in Pediatric Solid and Hematologic Malignancies 1969 857 2045 PMC11011897__F3 Proteomic Analysis of Salivary Extracellular Vesicles from COVID-19 Patients Reveals a Specific Anti-COVID-19 Response Protein Signature 619501 1191 7018 2244 3240 213 2266 2335 1356 2243 2200 1292 3908 1282 3911 3853 1277 3912 1284 3339 100187907 PMC11012077__F2 Chemokine Fractalkine and Non-Obstructive Coronary Artery Disease—Is There a Link? 7412 3383 6376 1524 5970 5971 PMC11015710__F2 Rosacea: Pathogenesis and Therapeutic Correlates 7097 4318 4313 7124 PMC11015925__F4 Circulating Levels of HOTAIR- lncRNA Are Associated with Disease Progression and Clinical Parameters in Type 2 Diabetes Patients 5170 6774 10891 4893 2308 5465 5594 3569 5581 3551 5295 5728 5601 PMC11016256__F1 Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis 8091 6495 7045 4092 4087 4088 4089 PMC11018843__F2 Alzheimer’s disease (AD) and cytosolic DNA sensors 10084 115004 3661 3454 29110 3627 3569 6772 9447 6773 PMC11018997__F6 Multiple functions of the nonstructural protein 3D in picornavirus infection 57506 3661 10010 64127 3455 7297 10379 3665 PMC11019011__F3 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity 6010 8313 8312 51339 1499 3479 3606 3569 860 1789 PMC11019011__F4 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity 4089 4086 4090 860 4087 4088 PMC11019011__F6 Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity 55366 3569 3606 4772 PMC11019510__F5 Role and mechanism of TXNDC5 in disease progression 367 619501 81567 PMC11019826__F8 Utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction–associated steatohepatitis 1958 4739 619501 PMC11033207__F10 Redox signaling and skeletal muscle adaptation during aerobic exercise 50507 5175 23411 3091 PMC11034561__F3 Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities 1950 1956 5654 54567 23462 23493 1958 PMC11039819__F2 Interplay between autophagy and cGAS-STING signaling and its implications for cancer 115004 3456 29110 3661 PMC11039944__F2 Alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma 174 960 4072 7852 PMC11040302__F1 Application of artificial hibernation technology in acute brain injury 5935 9332 4615 7099 PMC11040941__F6 C6orf15 promotes liver metastasis via WNT/Beta-catenin signalling in colorectal cancer 1499 51176 1374 PMC11210699__F3 Therapeutic effects of baicalin and baicalein 664 114548 627 79792 23411 PMC11211258__F1 Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment 3002 3001 114548 9447 3394 79792 56169 1687 55876 PMC11214400__F6 Inflammatory loop involving Staphylococcus aureus, IL-36G, and cathepsin S drives immunity disorders in familial acne inversa keratinocytes 23385 3458 920 9314 PMC11215075__F5 Ezetimibe, Niemann-Pick C1 like 1 inhibitor, modulates hepatic phospholipid metabolism to alleviate fat accumulation 9415 2180 7038 5091 10400 PMC9922515__F7 Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway 28971 4609 468 83667 PMC9942259__F7 LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/B‑catenin pathway 595 4318 4313 50943 7805 1000 999 PMC9951170__F2 When AHR signaling pathways meet viral infections 6714 196 405 57491 PMC11005058__F2 Adipocyte leptin promotes lymphocyte activation and TH17 differentiation 3953 3458 6774 613 PMC10757967__F1 Advances in the regulatory mechanisms of mTOR in necroptosis 64798 9675 729438 375 6009 PMC11013124__F1 Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches 54209 2475 114548 PMC11015775__F1 Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China 3586 3569 1043 324 7054 7039 PMC11033433__F6 Research progress on radiation resistance of cervical cancer 3065 4313 4316 PMC11216096__F2 Wnt signaling in gastric cancer: current progress and future prospects 7473 7482 7472 7471 7480 54361 7474 406932 100126310 999 4041 4040 1499 4919 4920 54894 324 6925 PMC11011519__F2 NFKB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury 1192 6774 718 PMC11016009__F4 B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention 920 6774 80328 PMC4631354__F3 Characterization of SCDs as Membrane Maintenance Regulators 2195 2196 120114 79633 PMC10514522__F2 Microglial metabolism shifts from OXPHOX to glycolysis in the inflammatory state 4615 4513 2475 5209 2539 7086 6888 790 PMC10514522__F3 Lipid metabolism in microglia in the inflammatory state 3949 4795 948 355 54209 348 4035 PMC10088895__F1 PD-1/PD-L1 pathway plays a role in immunosuppression 27040 7535 5728 940 324 PMC10093079__F5 Baicalein in regulating the cancer signaling pathways 2077 4193 2475 999 4088 1386 PMC10095454__F6 The mechanism by which SDC3 cooperates with the regulation of milk fat synthesis and inflammatory response 7124 9672 23411 5468 PMC10095594__F1 Canonical Wnt signaling pathway 4041 4040 324 1499 607 999 PMC10121351__F8 Schematic of the molecular mechanism underlying UA anticancer activity in NSCLC cells 3717 6774 1956 1950 6657 9429 PMC10125773__F5 TNFA signalling pathway 8717 7186 7187 8772 3550 7124 PMC10135105__F3 Activation of NRF2 signaling pathway by 4-HNE 9817 8452 4094 PMC10135467__F2 Illustration of the regulatory network of METTL3 in the nervous system 442904 6423 378938 390937 627 23237 7189 2146 4036 10683 9513 3164 266743 6657 7916 PMC10135714__F10 Schematic illustration shows the protective effect of extract of Lonicera japonica in particulate-matter (PM)2 4615 581 7124 PMC10135928__F7 Lipid synthesis in adipocyte differentiation and functions 9242 10682 2194 7038 8694 84649 948 PMC10136030__F1 Structure and functions of telomeres 7015 7012 25913 1200 472 545 PMC10136030__F3 TERT is involved in major signaling pathways and participates in regulation of gene expression 7015 331 581 572 PMC10136283__F7 KEGG pathway map for Wnt signaling pathway 6423 6424 147111 51701 324 4089 50964 4088 25805 6477 9978 2040 29984 9475 27130 6259 PMC10136307__F2 Inhibition and induction of autophagy 9776 8408 60673 7405 9140 9474 10533 83734 PMC10136307__F4 Proposed ER-related mechanisms in the induction of autophagy and UPR in B cells 596 22926 7494 7405 55626 83939 468 9474 57761 10533 9140 7248 7249 8408 9776 PMC10136495__F2 TGFB signaling pathway in LC development and metastasis 7046 6010 2475 6615 4313 4318 6935 7422 6657 79923 4609 50943 3569 PMC10136495__F3 Targeting TGFB signaling pathway in LC 7046 4313 4318 6935 7422 6657 79923 1282 4609 50943 3558 3569 PMC10136533__F2 Regulatory network of OTUD5 in immune response and DNA damage repair 4615 7187 29110 3661 3665 115004 51366 6749 6097 9141 7157 581 PMC10136533__F3 OTUD5 is involved in the development of cancer (see also Table 1) 55593 100420631 54546 64798 2475 729230 9141 7706 619501 7157 5371 5728 PMC10136584__F1 WNT signaling pathways 4041 4040 324 387 23002 847 998 51701 PMC10136831__F1 Biosynthesis of prostaglandins 4512 4513 5228 5226 PMC10136831__F3 Crosstalk between PGE2 and EGFR 1956 6714 1950 7018 2919 3579 PMC10136857__F1 Canonical and non-canonical Wnt signaling pathways in cholangiocytes and the role of the primary cilia in modulating these pathways 1499 324 4041 4040 387 5879 PMC10136927__F3 Targeting Wnt signaling pathway by the latest technologies 8549 8324 4041 4040 84133 54894 5754 324 1499 PMC10136970__F3 Pan-pathway inhibition 1950 1956 1019 1021 2885 5163 PMC10137108__F1 Contribution of various long non-coding RNAs and microRNAs in osteogenic pathways 4041 4040 10454 64750 8195 860 9759 1749 57154 324 1499 PMC10137108__F2 Bone formation by miRNAs 442915 860 50964 PMC10137108__F3 Long non-coding RNA that regulates osteosarcoma invasion and metastasis 85028 2261 100124700 PMC10137218__F4 WNK kinases regulate HCO3− versus Cl− secretion across human airway epithelia 435 65125 65268 130497 PMC10137309__F1 Extravasation steps in breast cancer brain metastasis 960 4582 100133941 7852 214 4312 81849 10855 4318 101 84879 1839 4513 2633 10507 PMC10137309__F2 Extravasation steps in melanoma brain metastasis 6275 4313 4318 54477 5340 1233 2833 PMC10137601__F7 Working model illustrating the mechanism that underlies the role of RA in regulating LH-induced oocyte meiotic resumption 5950 374 2069 1956 2002 1958 7538 4880 1267 4882 5139 PMC10138520__F3 Glycolysis and its relationship with other metabolic pathways in TNBC 29968 355 26227 PMC10138520__F5 Lipid metabolic reprogramming in TNBC 117581 4087 5228 231 7291 355 PMC10138595__F1 Cytokine Storm and ALI/ARDS Induced by Influenza Virus Infection 51284 3146 4615 3665 3661 920 PMC10138709__F2 Hedgehog signalling pathway 6469 51684 6608 55733 2735 5727 4609 79923 6657 PMC10138709__F3 Canonical and non-canonical Wnt signalling 847 324 6010 100653366 1386 PMC10138709__F5 Hippo pathway and its crosstalk with other signalling pathways 6010 4771 4485 154796 26524 9113 8473 51701 9686 324 1499 5784 182 374 PMC10138908__F7 Which OBHS remodels abnormal glycometabolism, referring the experiment results 3098 2539 5230 2023 PMC10139073__F2 S1PR function in osteogenic cells 1901 9294 1903 4513 8698 6010 1499 860 8877 PMC10139088__F5 Metabolic plasticity regulation on tumour microenvironment 2203 23152 5209 PMC10139088__F6 Metabolic regulation on tumour metastasis 6615 6935 6591 PMC10139189__F1 Migration and invasion of GBM cells is related to the inherent capacity and the cellular interactions that occur on the migratory front 6657 7474 3976 145258 1000 285 7054 7473 960 1524 7852 PMC10140952__F4 Selected molecular targets of resveratrol 367 6850 9474 10533 1958 581 9140 6774 22863 6772 2002 5728 9429 5243 1017 23411 3082 847 1956 5347 6647 6790 7099 3479 1576 PMC10141515__F5 Differentially expressed proteins of the glutamine metabolic pathway in ovarian cancer 586 2744 445 435 PMC10142331__F1 Mechanisms by which SFTS inhibits key immune signalling pathways and promotes inflammation 57506 3661 3665 6737 7706 581 6773 114548 10379 PMC10142331__F2 SFTSV mediates cell cycle, apoptosis, and the cGAS-STING pathway to achieve immune escape 983 115004 8678 29110 4149 PMC10144233__F1 Heme b biosynthesis pathway 11113 4118 3145 7390 1356 7389 PMC10144535__F7 Classical MAPK signaling pathway altered by 15 μM 7KCh treatment in mRPE cells and reversion effect exerted by 10 μM SA over this modulation 2885 4352 6722 4703 2002 PMC10145126__F2 PD-L1 regulation by IFNG 3716 3717 6772 3659 PMC10145673__F2 Molecular pathways involved in pituitary tumorigenesis 6608 3480 1956 4485 60485 51684 324 9113 5728 1499 7248 7249 6009 4193 572 PMC10145676__F1 Main metabolic pathways related to myo-inositol transformation inside the cell 51477 51447 9807 117283 3628 5163 253430 5728 PMC10147314__F4 Several signaling pathways are closely related to NEDD8 8453 7428 9040 9820 26524 9113 1956 PMC10158519__F7 Schematic diagram by GroA promotes of expressions of inflammatory mediator TNFA and COX-2 by activating NOD1/RIPK2-mediated JNK, ERK and p38 MAPK pathways in HNSCC progression and metastasis 3579 3577 8767 7124 10392 PMC10177044__F2 Ratio of p38 signaling to ERK determines whether cancer cells enter a dormant state or undergo proliferation 2662 22943 652 7049 58191 6376 3481 4313 4318 7852 3579 26585 4015 4017 3479 3082 PMC10177107__F1 Different signaling pathways and epigenetic mechanisms that have been deregulated during TNBC progression and growth, contributing to stemness 5728 2475 675 672 545 472 PMC10177184__F6 Evolutionary chart of human molecular pathway Akt 26548 6446 22985 65125 331 367 4193 9846 595 2932 2931 5753 2308 5209 9882 3320 23239 2624 7248 2475 572 7249 57521 64223 6714 672 5163 5164 1629 5728 11140 6247 4615 114609 3480 1839 10134 930 7099 6850 23643 2885 PMC10177184__F7 Evolutionary chart of human molecular pathway of EGFR signaling (A), Notch (B), and Hedgehog (C) pathways 5058 4214 6010 5879 1956 4133 5604 9053 867 2885 2002 9046 999 3716 3717 1950 6714 5747 2059 4582 1445 5163 2549 9712 6608 51684 PMC10177184__F9 Evolutionary chart of human molecular pathway of WNT signaling 2487 11197 5879 387 4041 324 2932 4316 5467 4897 9076 8507 4513 595 PMC10177463__F3 BRAF V600-Mutated Metastatic Melanoma and Targeted Therapy Resistance: An Update of the Current Knowledge 3082 6423 5159 4763 5728 8661 2475 5519 4286 1906 PMC10178209__F4 Biosynthetic pathway to produce patchoulol and Alpha- and Beta-santalol in S 5805 3652 3422 PMC10178682__F1 Simplified picture of cancer metabolism 3099 6510 2744 8140 2806 84706 1431 2271 PMC10178712__F5 RNA-sequencing analysis revealed the role of trimethylamine-N-oxide (TMAO)-mediated signaling in vascular dementia 7484 487 1536 3934 6279 4314 6347 6351 6696 PMC10178966__F3 Potential biotargets associated with the CI−AKI 7099 9734 114548 1800 54790 27250 10628 581 23410 90865 PMC10179184__F2 Mechanism of CYLD function in oxidative stress-induced DNA damage 90268 9825 1540 PMC10179295__F2 Paxillin participates in Wnt, integrin-FAK, and TGFB signaling pathways 387 7046 7048 4087 4088 2534 4089 PMC10179295__F3 Paxillin participates in MAPK and PI3K/AKT signaling pathways 1956 6714 11122 2002 595 PMC10179549__F10 HMGB2 in the development of the diseases 2203 3148 1499 2638 4313 115004 PMC10179672__F5 Key components involved in the regulation of activation/inactivation of the canonical or Wnt/Beta-catenin pathway 7472 324 1499 PMC10179893__F5 PS inhibits macrophage M2 polarization via IL-4/STAT6 signaling pathway, and in turn suppresses TAM-induced tumor progression 6778 383 8205 PMC10180405__F3 BMP-2 and Wnt/Beta-catenin signaling pathways participate in the pharmacological activity of naringin in mediating osteogenic differentiation 4089 4090 4041 4040 8313 324 1499 860 6925 PMC10180667__F4 “Components-targets-pathways” network 2932 898 5578 5590 3091 5601 6772 4170 5159 6513 2645 5054 4843 3688 1017 7099 4313 1147 4790 3320 5295 PMC10181312__F2 Circadian clock system involved in regulating photoperiodic flowering in Arabidopsis, soybean, and rice 64326 1999 55615 574414 80758 10938 91869 PMC10187169__F2 Pathways included in the model 3280 8829 7428 6714 5728 7249 5163 6009 PMC10189743__F5 Involvement of ITGA and ITGB receptors in ‘focal adhesion’ and ‘ECM receptor interaction’ from the Kyoto Encyclopaedia of Genes and Genomes pathway database 387 7408 3611 5728 998 1398 126669 572 PMC10193376__F4 Protein network encoded by jointly regulated genes 4646 4294 4638 57533 7576 63891 6271 9534 4325 1300 284443 8030 64386 1956 3075 81856 51351 57617 738 26959 4651 51621 94241 5728 605 22834 8317 1870 93134 51362 170959 PMC10198048__F7 Working model of how Cas regulates osteoclastogenesis 7189 4772 1513 4318 81501 PMC10198710__F3 m6A methylases that participate in ferroptosis 56339 54915 10644 51441 79068 57721 64848 7018 23657 6520 81539 6510 7037 2879 7074 54890 PMC10215085__F9 Hypothetical molecular mechanism model was developed for the influence of starch on the growth and proliferation of B 610 10021 2821 5211 PMC10215262__F1 Canonical Wnt pathway 324 4041 4040 607 3725 998 4920 4919 1499 387 PMC10215584__F5 PPI network analysis according to STRING database and KEGG pathway enriched in DEPs in the groups of (A) MRC vs 83876 729359 3910 3158 4126 3155 10449 5579 2588 7169 1281 1811 3163 7068 208 PMC10215600__F1 Nrf2 and SIRT1 signaling pathways regulation by antioxidants 5728 9817 23411 2309 4504 PMC10216079__F3 Main signaling pathway in rheumatoid arthritis 7124 5163 324 2475 1499 PMC10216286__F2 TRAIL resistance 1637 8772 637 581 331 PMC10216337__F2 Schematic representing the suspected roles of and molecular pathways involving MeCP2 in colorectal-cancer progression 4204 6688 9314 6935 6657 999 10644 57721 56339 PMC10216337__F3 Schematic representing the suggested roles of and molecular pathways involving MeCP2 in pancreatic cancer 4204 5045 1000 999 79727 6657 79923 389421 PMC10216404__F2 Effects of RSV on activation of SIRT1 signalling pathway 6662 4772 23411 860 9242 6648 PMC10216440__F2 CGRP cellular pathway 10267 121340 860 468 PMC10216514__F5 Ferroptosis signaling pathway 7018 6510 2744 2937 2879 PMC10216619__F2 Adiponectin paradox and its related pathways during COVID-19 infection 7113 59272 3146 1012 PMC10216619__F4 Possible neurological and mental COVID-19 outcomes related to the angiotensin-converting enzyme 2/Mas/brain-derived neurotrophic factor (ACE2\Mas\BDNF) signaling pathway occupation by SARS-CoV-2 1636 59272 627 7113 581 3553 PMC10216727__F2 Role and function of FOXM1 in pulmonary fibrosis 2247 6774 55611 59 4088 595 891 5347 7124 6935 4313 PMC10217168__F14 Graphical summary of the protective effect of Lactiplantibacillus plantarum Lac16 against enterohemorrhagic E 7099 8324 7054 4615 581 7189 1499 8313 595 PMC10217556__F1 Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain 4282 972 7852 3146 7099 PMC10217562__F5 KEGG diagram of plant hormone signal transduction pathway under salt stress 64641 1879 51411 4881 PMC10217969__F5 Transcriptome and Metabolome Reveal Distinct Sugar Accumulation Pattern between PCNA and PCA Mature Persimmon Fruit 11181 2992 2632 355 PMC10218067__F7 Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo 8900 1017 898 596 2475 PMC10218387__F3 Major pathways of carbon and energy metabolism in M382 25796 7086 1896 6608 8190 64902 828 4190 PMC10218397__F9 TASE and thymol supplementation in neuronal differentiation and outgrowth effect 4133 55577 627 PMC10218668__F1 Therapeutic peptides for lung diseases 114548 7432 387569 1267 26291 PMC10218870__F1 Schematic diagram showing the main molecular targets of luteolin during the initial steps of the metastatic cascade 581 4193 1000 4851 999 6714 6774 2475 8323 PMC10221447__F3 Natural Products Targeting PI3K/AKT in Myocardial Ischemic Reperfusion Injury: A Scoping Review 581 7124 22926 2922 PMC10222048__F3 KEGG pathway analysis of glycolysis and gluconeogenesis 1368 84532 221 2023 57818 3945 5106 5207 5160 55276 PMC10222578__F5 Networks of interactions between the genes affected by the production of sfRNA in ZIKV infection of human brain organoids 51176 51199 94 116512 339122 7809 10980 84435 10682 1959 4192 29767 162515 770 3726 3845 1026 1019 894 130497 8793 55388 4170 5457 896 3240 7422 1740 57282 1641 23272 338 2919 51083 56146 83667 64065 355 8930 81542 4803 3033 5915 9531 5081 10553 56005 1420 226 80070 10039 3024 8208 8975 8339 23304 55170 2152 PMC10222578__F6 Interconnection between sfRNA-affected biological processes in ZIKV-infected human brain organoids 10039 2152 2099 10600 8110 11341 56005 5081 116512 339122 10553 29079 5728 55179 5473 1740 894 770 79971 595 23166 1038 6608 1969 1959 3845 PMC10223558__F5 Networking among differentially expressed genes (DEGs) and pathways identified via GSEA 163351 1586 23705 3437 130367 10316 8993 23037 9200 401262 2006 1154 2001 1983 570 4232 64122 479 23205 29785 222 192134 6347 3627 1281 1612 7431 3383 23563 23127 6289 727936 55217 146664 26301 316 10965 284486 4842 5837 270 7124 4314 27115 9966 5803 230 9955 5152 8013 241 6296 239 2272 6097 2819 8991 90161 383 374907 643414 84532 212 56667 9162 7512 26027 1295 57571 7851 51179 2643 5563 9252 8654 118788 3635 2974 1128 634 3481 1278 875 7058 8515 8639 4969 1956 3909 6652 158067 3381 1298 5294 9542 2887 8437 1101 4638 1293 448834 441478 25780 80310 124975 2940 5284 5753 2941 50487 4609 10125 85409 4773 285 2944 654 81029 64399 54361 2902 8061 11069 2846 10411 23236 3684 10636 PMC10223558__F6 Identification of key hub genes 2687 4258 2940 2974 9252 3635 1612 7431 3627 3383 7124 5563 8013 3481 1278 7058 8515 1293 3381 3485 3484 3486 3482 9547 80310 79923 947 340348 5460 1636 6387 7852 2833 5054 25802 92949 2626 1101 3909 5175 81792 4638 6347 81794 59 2941 2887 4609 1298 25780 50487 5294 54361 3684 285 2902 810 871 4060 1290 7076 1281 4314 4015 2006 81029 1277 3689 10636 5329 7045 8710 23236 26577 4322 3479 124975 241 3434 PMC10223558__F8 Expression analysis of genes involved in PI3-AKT-mTOR pathway post MMTV expression 80310 285 3479 3481 7248 6009 2475 7249 25780 672 54361 4609 595 5163 5934 2885 3667 7097 7099 5879 613 6850 930 11140 1277 1278 5728 572 842 4193 PMC10223772__F5 Proteins related to resistance in HIGS lines infected with A. flavus 7018 2077 4602 375298 4015 PMC10224166__F3 Anti-inflammatory effect and mechanism of atractylenolide I and III 7099 4615 2357 3717 6774 PMC10224166__F4 Anti-cancer effects and mechanism of atractylenolide I, II, and III 7099 3717 4615 1728 6774 2475 983 637 1017 581 150365 572 PMC10224264__F3 Hypothesized mechanism of coronavirus-induced neuronal damage via oxidative stress and mitochondria dysfunction 59272 7113 100379198 3553 PMC10224264__F5 Anti-apoptotic and anti-inflammatory effects of Ginkgo biloba extract (EGb) and its constituents 1020 2932 6772 6774 PMC10232107__F2 Compound-gene targets-signaling pathway network of the eight phytochemicals related to neuroinflammation 7124 100187761 4846 6714 836 5468 PMC10245950__F9 ß-oxidation pathway for fatty acids is strongly downregulated by oxaliplatin 2180 1375 1376 729 1892 3030 4967 3032 3033 38 PMC10245950__F10 TCA cycle is affected by oxaliplatin 51660 25874 1431 3419 50 3420 4191 4967 6389 1743 8802 8803 8801 PMC10245950__F12 Glycolysis in cardiomyocytes is upregulated in the oxaliplatin treated mice 3098 3099 3101 2645 140805 5230 5223 5224 8789 226 229 2023 2027 2026 5315 2597 3939 3945 PMC10245950__F13 Effect of oxaliplatin on NAD+ and NADP+ synthesis and salvage pathways 23530 952 4860 10135 92014 23410 22933 23411 683 23409 65220 59084 5168 5167 22875 83594 133121 5169 64802 349565 PMC10252036__F2 Various mechanisms that have been reported to regulate epithelial–mesenchymal transition (EMT) in SACC patients 1950 3082 3091 2475 1000 2335 7431 999 4602 1499 2932 324 4781 PMC10252624__F2 Primary mechanisms of ICIs-associated cardiotoxicity 324 940 1493 PMC10252649__F1 mTOR Signaling Pathway in Bone Diseases Associated with Hyperglycemia 2308 64798 5163 2887 7248 7249 6009 7942 8408 PMC10253150__F6 Wnt signaling pathway, including the canonical pathway, the pathway associated with cell polarity determination (Wnt/PCP), and an increase in intracellular Ca2+ (Wnt/Ca2+), whose genes were significantly regulated in the ZG zone 64840 11197 147111 9350 22943 27123 27121 50964 6424 6423 6259 4920 2239 23236 5330 1855 85407 5331 80319 5332 59343 1856 1857 85409 23401 1457 1460 27130 23500 387 324 1499 9475 5530 5578 122011 815 5579 816 5533 5534 5535 818 6885 64321 4772 4773 6932 4775 1487 1488 6934 4609 8061 595 3725 894 5328 83439 51176 51701 PMC10253150__F7 Biogenic amine synthesis signaling pathway, whose genes were characterized by expression significantly regulated in the adrenal medulla 1103 43 3067 1644 2571 2572 4128 7166 1621 15 438 5409 1312 5053 7054 PMC10253263__F6 Signaling pathway of PNPLA3-I148M-induced activation of LX-2 cells 80339 9619 1281 4313 7076 7077 9927 6647 PMC10253306__F3 Splicing Modulators Are Involved in Human Polyglutamine Diversification via Protein Complexes Shuttling between Nucleus and Cytoplasm 7415 2885 9001 10013 998 6010 PMC10253382__F3 Anti-inflammatory pathways induced by baicalin 2308 7099 9021 3146 2932 114548 PMC10253673__F1 Potential mechanisms by which alcohol modulates Alzheimer’s disease (AD) pathology 23621 351 1020 2475 PMC10254162__F11 FAK/Src signaling pathway 6714 1398 1793 998 PMC10254355__F4 CIN and MSI signaling pathways in colorectal epithelial cancer: A modified cartoon from KEGG depicts known activated pathways in colorectal epithelial cells 29110 324 1499 595 83732 572 1147 4087 4088 4089 581 7046 1956 2475 51426 PMC10255416__F7 Supplementation affects metabolic reprogramming of cumulus cells in aging ovarian patients 3939 3099 2821 3417 3418 8803 2023 2026 48 50 6389 6390 1431 2271 4190 4191 3945 5162 PMC10255599__F2 Vitamin D and resveratrol immune response against SARS-CoV-2 infection 1594 10682 7421 23411 10010 920 6774 114548 PMC10266771__F1 Proposed mechanism for the regulation of NRAS mutation-driven hematopoietic malignancies involves the CBL/JAK2/RAB27B signaling axis 867 3717 5874 4893 51114 PMC10272955__F8 Graphical summary of the signaling pathway that mediates fenofibrate (FF)-induced cytoprotection against cisplatin toxicity 196 6648 9817 PMC10286592__F3 Alteration of mTOR signalling pathway post TBI 8408 2475 5163 7248 6009 PMC10295080__F1 Nrf2 signalling pathway 8452 9817 2730 7296 PMC10295928__F5 MiRNA-assisted targeted therapy 100616132 1956 3480 3481 3066 2099 3667 3845 6935 6009 2475 3082 960 558 4582 6696 6469 PMC10295928__F6 MiRNA-assisted immunotherapy 6351 3716 3717 6935 100505641 5728 693161 PMC10296674__F3 Canonical pathways derived using the IPA tool 6464 5728 80243 81858 572 596 595 PMC10296711__F8 Schematic illustration of the TLR/IL1/IRAK/NFKB inflammatory signaling pathway axis 4615 3656 51135 11213 3654 7189 5970 10454 23118 3552 PMC10296711__F10 Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer 7096 7097 7099 10333 7098 4615 51311 51284 54106 81793 3656 51135 11213 3654 7189 29110 354 367 4609 4613 6657 6790 3661 3665 2146 961 PMC10296830__F1 The Hippo pathway and YAP/TAZ mechanosignaling 4485 60485 26524 9113 5597 5598 9411 387 PMC10297136__F3 Signal pathways associated with lung adenocarcinoma 4763 1956 324 6794 7248 7249 4193 2475 7157 472 PMC10297136__F5 Glioblastoma multiforme (GBM)-related signal pathways 1030 1956 4763 1019 5925 2475 7157 PMC10297376__F2 PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds 5728 64223 5163 2475 64798 253260 143686 8408 9776 7248 6010 7249 572 6009 595 1977 PMC10297881__F12 Apoptosis and p53 signaling pathway in the control compared to adipocytes, chondrocytes, neural-like cells and osteoblasts 153090 9133 8503 10376 7057 84790 9020 595 3708 6708 5295 330 3479 1111 901 10018 1513 51512 597 5293 891 8797 983 637 83667 1509 9451 4001 7277 6477 1520 2353 4803 9134 5054 1021 6241 60 7846 8837 7124 PMC10297881__F13 Apoptosis and p53 signaling pathway in all analyzed groups 10018 3710 1514 1643 83667 7057 143686 1075 7277 1520 330 1021 3708 6477 1647 8797 4803 4616 1519 2353 3479 1649 1029 5293 27244 597 5295 8743 3551 1512 6241 983 51512 332 596 4001 894 5602 7124 9133 8837 PMC10298151__F7 Diagram showing the mechanisms involved in D2R Beta-arrestin-dependent pathway-mediated ERK activation 156 4193 6714 PMC10298332__F4 The TNF signalling pathway by M-glucans 7124 8772 840 718 836 83737 8717 4703 197259 1437 8809 3976 9021 4323 64127 6401 3659 PMC10298332__F5 The C-type lectin pathway by M-glucans 4046 5971 6850 7124 868 387 1540 602 6367 6361 4193 3659 PMC10298332__F6 The IL-17 signalling pathway by M-glucans 920 8772 55540 4099 7187 1601 257397 84818 9618 29761 4513 4163 6280 4318 3458 7189 PMC10299014__F1 IL-17RA/RC signalling pathways (Figure adapted from Monin and Gaffen , and from Chung ) 10682 7189 84818 7186 PMC10299070__F3 Core pathways involved in development of Peyronie’s disease and their interrelationships 6469 6608 5727 22943 6422 387 4092 4087 4088 3479 4089 5054 3164 PMC10299206__F3 Relationship between genes related to TGFB signaling pathway and pathogenesis of oral cancers 7045 1019 864 383 4609 4087 4089 7295 7189 PMC10300974__F5 Hypericum perforatum L. and the Underlying Molecular Mechanisms for Its Choleretic, Cholagogue, and Regenerative Properties † 6714 3383 1956 581 7097 6279 2920 3579 3611 PMC10300995__F2 Altered amino acid metabolism and potential drugs in DLBCL 4609 10419 2744 23410 PMC10300995__F4 Influence of altered tumor metabolism on immune cells 3002 383 8205 56670 PMC10301029__F1 Tyrosine kinase (EGF pathway) and Wnt/Beta-catenin pathways 4041 4040 324 1499 1950 1956 1398 2885 6772 6774 10818 4513 27289 4318 PMC10301029__F2 Overlap between the tyrosine kinase pathway, Wnt/Beta-catenin, and prostaglandin inflammation pathways 2247 4513 6932 1499 PMC10301029__F3 EMT transition pathway 7124 126669 3611 4087 4088 6714 2885 1499 6774 51176 9839 6935 8841 3066 3065 1786 PMC10302309__F2 Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application of New Therapeutic Strategies 1956 238 6098 5979 4914 3845 5728 673 2475 595 894 898 1019 1021 7157 5925 PMC10304248__F2 Mycobacterium tuberculosis and apoptosis modulation 7124 8717 8772 581 637 331 PMC10304248__F3 Mycobacterium tuberculosis and the necrotic-like cell death modulation 7124 4615 3654 7189 64127 114548 8717 7186 8737 11035 2879 5524 10892 80712 5478 197259 23118 257397 79792 PMC10304636__F4 Schematic diagram representing cardioprotective molecular mechanisms of GLP-1 analogs in cardiomyocytes 2740 55669 9927 1821 2876 581 572 2475 PMC10305000__F6 Reconstructed fatty acid synthesis pathway of ST7-B 2539 2821 2820 1738 1737 PMC10305525__F2 Three major H2S synthesis pathways are of enzymatic, non-enzymatic, and gut microbial origin 1610 875 847 23474 PMC10312928__F5 Protein-protein interaction network and functional enrichment analysis of proteins with acetylation, carbamylation and phosphorylation sites regulated by bacterial lipopolysaccharide 3068 4000 7150 226 81 57817 1655 5902 1973 9097 1642 5339 6232 7317 6059 4602 9188 9031 58508 7431 302 10487 PMC10312929__F8 Wnt signaling pathway 51701 147111 324 4089 50964 4088 25805 847 27130 6259 6477 9475 PMC10313365__F8 Roadmap of molecular changes and cellular phenotypes when cells lose MLL3/4-COMPASS 11091 9070 5929 84661 23054 PMC10318600__F1 Signaling pathway of ferroptosis 2936 2879 8031 PMC10340792__F2 Targeting transcription factor YY1 for antitumor therapy 7528 3297 65986 355 100873962 367 2064 941 5214 29904 693220 1956 PMC10341274__F2 Contrasting roles of AGRP and POMC neurons in glucose and lipid homeostasis 3953 2693 181 5443 23237 PMC10341343__F2 Glucose metabolism in cancer cells 2821 2147 5209 5210 2597 5230 26227 5223 3939 3945 5132 PMC10341567__F1 Main pathways involved in cholesterol transport involved in Alzheimer’s Disease 22937 348 19 2932 4035 10858 54209 351 23621 PMC10341681__F2 Signaling pathways and targets of AB metabolism regulation by saponins 351 558 102 7942 3416 PMC10341681__F3 Signaling pathways and targets of saponin-regulated tau protein phosphorylation 3667 51451 1020 PMC10341681__F4 Signaling pathways and targets of saponins against neuroinflammation in AD 50507 30812 1499 1017 PMC10341681__F5 Signaling pathways and targets of saponins against oxidative stress in AD 1499 50507 847 2950 2729 PMC10341681__F6 Signaling pathways and targets of saponins against apoptosis in AD 7186 627 30812 1499 PMC10341927__F10 Identification of Moesin (MSN) as a Potential Therapeutic Target for Colorectal Cancer via the Beta-Catenin-RUNX2 Axis 4478 1499 860 PMC10341943__F3 Role of the Notch pathway in cell-fate decisions in the somite 5077 10660 5175 PMC10342783__F9 Phenylalanine metabolism (a) and neuroactive ligand-receptor interaction (b) KEGG pathway 51738 2693 10911 2837 799 551 1392 4295 2862 2696 2798 10874 5367 7200 7201 8620 2492 4852 2691 3972 7253 4018 5741 8862 2925 4922 6343 6344 1241 7432 3060 718 5737 727 5020 5021 2690 6750 885 3952 6865 3953 51083 6866 6870 5618 PMC10343257__F10 Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha 5163 114548 2475 PMC10344634__F10 Graphical abstract 10980 226 999 1000 PMC10346248__F11 Schematic models of the NRF2 signaling pathway and its regulatory mechanisms in human skeletal muscle 8452 9817 729 PMC10346484__F2 Key metabolic pathways for the biosynthesis of NEAAs, the enzymes in each pathway, and the main functions of each AA [54,173] 5723 51699 6472 6470 27430 4144 191 635 23743 4548 55256 5053 2875 84706 27165 2752 2805 2806 2746 2747 440 80150 175 29920 4942 2475 PMC10348770__F1 Treg-mediated immunosuppression and resolution of lung inflammation 7124 7409 5879 PMC10367548__F8 The mechanism by purinergic receptor P2Y12 drives ConA-mediated autoimmune hepatitis through hexokinase 2-dependent glycolysis pathway 64805 3099 3458 PMC10367567__F1 CXCL12-CXCR4/CXCR7 signaling pathway 7852 6387 572 324 1499 PMC10377024__F2 Landscape of Genetic Mutations in Appendiceal Cancers 472 7157 545 7046 1026 7048 4087 4088 4089 4851 4854 4855 100188776 5728 7039 1956 1950 3265 2885 3845 673 4609 2322 5336 3082 5900 6010 2767 2778 2932 324 1499 4041 4040 PMC10377024__F7 Landscape of Genetic Mutations in Appendiceal Cancers 4851 4855 4854 100188776 2767 387 2778 8312 324 2932 1499 4041 4040 4609 PMC10379831__F1 Deciphering the Signaling Mechanisms of Osteosarcoma Tumorigenesis 2475 3569 558 5728 2735 7018 6608 4193 7249 4609 596 572 6935 9839 79923 6657 6662 100188776 PMC10380015__F3 Activation of the adaptive immune system via various receptors, different interleukins and its receptors, and the Janus kinases (JAK) STAT pathway 85480 3597 133396 3716 3717 7297 3718 6850 695 6778 6774 6772 6775 196 8989 3598 84565 PMC10380296__F5 Significantly DEGs identified by KEGG in protein digestion and absorption pathways (ko04974) 1506 4666 7462 PMC10380946__F4 Illustrates the apoptosis mechanisms triggered by DHA 355 8772 7124 8717 1956 847 2475 572 637 317 29948 6774 7494 22926 468 331 83939 6382 5728 7099 PMC10380946__F7 ARA on apoptotic death pathways 355 8772 83939 3611 317 PMC10385841__F4 Rotavirus interactions with the host innate immune system 57506 3661 6370 56477 3454 6773 6772 10379 4938 4599 3455 338376 3569 PMC10385841__F6 Top networks associated with lipid metabolism identified in PIEs infected with G5P 579 5208 3090 50937 11095 4542 26047 4360 64084 8564 23768 5099 54510 79782 9734 PMC10394732__F2 Mechanisms involved in mutant p53 exerting GOF effects 7018 3574 4609 6602 983 581 PMC10398793__F4 In the IPA data software the disease and function analysis of the RNA sequencing data from Primbio 1869 2101 1848 2308 3576 8678 2932 3006 3091 1356 4609 2475 84557 5594 6300 3297 PMC10407612__F8 Ghrelin in promotion of ADMSCs cardiomyocyte differentiation 10521 6424 1499 2626 7139 PMC10411462__F8 Function and mechanism of PARP inhibitor in thyroid cancers 142 100187907 27292 81847 PMC10411465__F2 Gut microbiota-derived metabolites in AAD 51596 51076 2328 PMC10411465__F3 Major amino acid metabolic pathway involves AAD 4397 23411 384 4313 4318 920 3276 10873 PMC10411465__F4 Alterations of polyunsaturated fatty acids metabolic pathways in AAD 2717 4313 4318 3383 7412 PMC10417163__F2 Signaling pathways play an essential role in organizing the Golgi apparatus and maintaining neuronal polarity during neurogenesis 23760 5306 10494 1600 64083 399687 375 387 PMC10417430__F4 Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level 5293 5371 2932 5295 5296 8503 5289 23411 7186 7343 9878 246751 891 7157 4193 355 317 64393 64065 836 54205 27324 7531 207 208 7534 7532 2033 7529 7533 10971 5515 7341 6613 2810 55602 5591 896 1019 1020 5925 983 595 153527 5728 51512 9134 6241 993 1111 56254 2475 9219 8841 3065 6598 6597 3329 3732 7057 23049 1643 27244 7249 83667 8493 PMC10417430__F8 Synergistic effect of N3a with HSPs and mTOR inhibitors in lymphoma cells: Summary of the therapeutic scheme followed in our study, with major findings highlighted in bold 2475 4193 4827 PMC10417792__F1 The MET signaling pathway and the sites of action for MET targeted therapies 3082 5879 6714 2885 2549 6774 2475 1956 PMC10418437__F1 Signaling pathways activated by free mtDNA in the pathogenesis of metabolic syndrome 29110 115004 54106 4615 23118 257397 114548 7189 3665 3661 3553 PMC10418609__F8 Expression of the DBNDD1 signaling pathway in prostate cancer (MetaCore) 5879 572 3356 4803 2247 2260 3667 2549 2885 10023 1385 324 PMC10418884__F10 Regulatory pathway of GR 2638 6714 4703 PMC10418941__F4 LSCs mechanism that employs fat as fuel 79923 6657 240 PMC10419059__F2 Insulin and IGF-1 signalling pathway 3479 3480 5163 2932 PMC10419059__F3 Wnt/Beta-catenin signalling pathway 1499 6422 22943 27123 4038 4041 4040 324 PMC10419152__F1 MAPK signaling pathways in mammalian cells: The MAPK signaling pathways are mediated by highly conserved MAPKs, which are activated sequentially 7096 7100 7099 10333 7097 387 7186 7187 7189 4615 6714 998 4342 23118 PMC10419152__F2 Mammalian MAPK pathways by effector proteins: This figure depicts the various components of MAPK pathways targeted by the bacterial effector proteins 5879 7189 998 6010 PMC10419312__F2 Macrophages in CTD-ILD 6347 6383 7124 6362 PMC10419859__F2 ATX/LPA signaling pathway in different inflammatory diseases 4023 4018 6010 4397 PMC10420029__F8 Transcription related pathways in the seminal tissues of P 5901 51808 51068 23440 2000 6396 9972 79023 79902 1998 1997 10209 9669 79228 57122 348995 80145 23636 9688 10605 8021 23165 53371 23511 9883 5903 1975 22827 11017 10523 10569 4116 151903 55696 9716 6908 6880 6878 6873 6879 1022 902 6882 83860 6874 6884 8148 6883 6881 PMC10420029__F11 Fanconi anemia pathway of P 84126 1196 545 57697 91442 80198 197342 146956 7398 2067 84464 2187 2175 80233 3280 55215 2177 2176 55120 2189 2178 80010 116028 29089 2188 641 22909 51455 27434 675 5889 11201 51426 5888 672 4292 5395 PMC10420029__F12 mTOR signaling pathway of P 2475 83667 220441 6520 201163 2932 64798 6009 1977 5728 253260 6010 6446 PMC10420159__F1 Immune checkpoints in a tumor microenvironment (TME) 325 942 941 3902 11148 PMC10421513__F10 Structure Characterization and Immunomodulatory Activity of Misgurnus anguillicaudatus Carbohydrates 51295 114609 4615 54472 7189 23118 10454 3725 PMC10433440__F6 (A and B) Illustration of classical and non-classical Wnt/Beta-catenin signaling pathways 7939 1499 324 PMC10450211__F1 An Illustration of the circRNAs that directly or through specific miRNA sponges activate the Wnt signaling pathway and play a role in the progression of lung cancer 57448 100302132 100302208 11279 4858 7678 7203 2252 7124 8322 5326 6659 PMC10450211__F2 Circular RNAs: novel actors of Wnt signaling pathway in lung cancer progression 83737 100302136 22943 1499 PMC10451232__F4 Transcriptomic changes in p53-associated apoptotic signaling in burn-wound-healing pathway 4193 3082 3725 836 6351 596 7124 637 841 578 842 581 7157 666 4790 317 5366 3034 3479 PMC10451380__F1 Scheme of the NRF2 signaling pathway 9817 9978 8452 8454 2810 4094 PMC10451660__F3 AhR signaling pathway 6714 196 405 57491 1545 PMC10451954__F1 Primary Coenzyme Q10 Deficiency: An Update 27235 23590 57107 51117 51805 84274 10229 56997 57017 93058 80219 51004 79934 PMC10451996__F12 Mechanism by which fibroblast upregulation of VDR suppresses lung fibroblast proliferation and activation during pulmonary fibrosis 7421 3716 6774 22926 PMC10452344__F1 Influence of microRNAs on the hippo signaling pathway in gliomas 4771 4485 9113 5771 5784 10413 7003 PMC10452661__F1 PI3K/AKT/mTOR pathway-related gene alterations involved in the pathogenesis of Endometriosis and Endometriosis-Associated Ovarian Cancer 5290 207 2064 5295 5728 8289 PMC10452677__F1 Relevance network of genes, transcription factors, small molecules, functional classes, miRNA, and biological processes that are shared between DMD and HMB (based on Pathway Studio Web Mammalian) 7124 7040 3479 2660 3569 3952 1440 3586 3458 84676 2308 23411 4618 581 PMC10452754__F2 The molecular interaction between HLA-G and decidual NK cells at the maternal–fetal interface 3135 3805 5164 5087 5764 4969 4513 PMC10453069__F2 ATM- and ATR-mediated pathways in the presence of damaged DNA 472 3014 545 11073 7465 7157 7161 983 PMC10453069__F3 Excision repair pathways of DNA single-strand breaks 27301 328 2956 4436 4968 5395 4292 27030 7508 4437 7515 2067 9156 2071 175 5111 3978 3980 PMC10453069__F4 DNA repair pathways of DNA double-strand breaks 10111 142 4361 4683 5932 9156 641 64421 7486 10721 3981 3980 472 11073 675 545 79728 5888 672 2176 2175 2177 2188 PMC10453169__F2 Schematic model of the canonical HH signaling pathway 6608 51684 50846 3549 6469 PMC10453317__F2 GAB1 recruitment modes to activated receptors and major GAB1 signaling pathways 2549 1398 2885 PMC10453365__F1 Ethanol Induces Neuroinflammation in a Chronic Plus Binge Mouse Model of Alcohol Use Disorder via TLR4 and MyD88-Dependent Signaling 7099 4615 3654 51135 7189 2353 3725 3661 3665 4513 PMC10453526__F2 Nodes and tracks of the cholinergic anti-inflammatory pathway 6774 3606 7124 PMC10453554__F1 Cyclin K-CDK12/13 complexes affect important biological processes and contribute to cancer development by phosphorylating different targets 8621 51755 1283 5062 672 PMC10454035__F2 Hedgehog (Hh) signaling pathway, normal and with Gorlin syndrome 2736 2737 2735 6608 51684 5727 8643 PMC10454115__F4 Mechanisms of Pi, Tf, Td, and Cr in AS 7018 7097 7099 PMC10454149__F2 MiRNA-146a—A Key Player in Immunity and Diseases 27040 142 472 613 6850 29760 695 375616 7189 331 8717 1540 10913 7124 7706 3929 929 114609 4615 7099 958 4049 4050 4055 7187 5899 PMC10454457__F3 Constitutively expressed genes of class I and II major histocompatibility complex processes of endogenous and exogenous antigen processing pathways found in chicken thrombocytes 567 821 6892 6890 6891 972 811 PMC10454700__F3 Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells 4041 1499 3065 650 PMC10454700__F4 Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells 7043 998 10454 860 3630 3479 1749 3569 PMC10458348__F4 Histone Modification of Colorectal Cancer by Natural Products 324 2932 1499 4040 4609 960 100187761 PMC10458661__F2 TLR and RLR signaling pathways present in airway epithelial cells in response to viral infections 7097 51284 51311 7099 4615 54106 7098 29110 PMC10458925__F1 EGFR/PI3K/AKT/mTOR signaling pathway 1956 64798 6009 5728 5163 7248 7249 PMC10459054__F2 Anti-cancer mechanisms of five agents (1) resveratrol induces growth inhibition and apoptosis in colon cancer DLD-1 cells by reducing miRNA-96 expression through MAPK/ERK1/2 signaling pathway activation 1956 2475 2065 100616182 581 2122 9245 6774 PMC10459248__F2 Cellular pathways modulated by ASFV 912 1438 3460 3459 3454 3455 163702 3588 965 9332 3716 3717 7297 10379 6773 6772 6774 3916 3920 8408 115004 4864 23339 5530 3838 3839 3840 6737 3661 3665 2033 114548 PMC10466072__F9 Schematic diagram 999 1019 11186 5728 4485 60485 26524 9113 1021 PMC10471462__F1 Hippo pathway is a signaling pathway that regulates the self-renewal and differentiation of hematopoietic stem cells (HSCs) 4771 4485 26524 9113 998 6010 861 PMC10471462__F2 Hippo pathway is involved in T cell development 81704 92597 55233 920 4485 5879 2309 2308 2152 50943 6774 PMC10475367__F2 Kyoto Encyclopedia of Genes and Genomes pathway of target genes in CRC 324 2932 387569 1630 836 1499 4087 4089 581 4436 595 10000 572 842 673 5900 54205 4437 2956 PMC10476815__F6 Predicted targets of Ruxian Shuhou prescription in the PI3-Akt signaling pathway 2475 51083 6009 7249 2885 613 6850 930 4609 951 5934 5728 572 842 6256 4193 PMC10478283__F8 Mechanism diagram 9242 5460 6657 79923 3214 7852 PMC10478443__F4 Functional enrichment analysis of IGF2BP1 regulated pathways in B-ALL 3417 36 1352 9277 7529 677 10959 7098 23481 56902 1349 2806 5718 27350 5708 3192 57493 6667 9991 1665 1736 5685 23394 581 5683 54790 10440 27339 9343 861 8195 1478 4205 2107 5695 25879 351 5579 54205 4942 23636 55226 3191 51621 5725 5324 55720 10940 607 2308 5613 2821 55759 6792 92609 10236 1399 8867 1374 26168 5707 6668 3845 5690 10785 56993 25926 54517 5901 4700 10189 867 23767 5594 5701 27340 79084 84946 6426 5684 6427 2521 4720 37 6834 89941 2322 5911 5037 7071 19 6515 4084 6815 8553 1316 26191 3965 5734 3383 5187 146850 10019 64762 9770 3735 8660 4783 3146 388 51114 7531 3725 2081 11314 85358 389840 1843 259 7018 5605 9590 5341 467 1435 7040 23764 1051 5052 1647 182 6647 23135 29937 23645 177 4035 3654 10365 205 27346 3939 29968 10197 6917 2632 10962 8935 9695 3992 811 3329 7296 3638 134429 9415 10061 57761 6117 871 7037 6241 1717 5033 4860 899 5347 928 2936 7374 5163 2539 440 5629 10452 54541 5478 586 10212 10642 22809 9294 958 115650 10970 1400 3109 1523 84293 2078 2272 6664 3118 10763 2788 94241 4293 4481 9811 389384 894 135228 8635 8795 3669 8829 3556 5896 5457 113791 6720 PMC10478475__F8 Hypothesized mechanism by which Ex-4 reduces tau hyperphosphorylation via Wnt/Beta-catenin/NeuroD1 signalling in T2D models 1499 324 4760 PMC10480466__F7 Lenvatinib inhibition of EMT in ICC cells 563 4088 999 1000 PMC10483926__F7 Illustration of a hypothetical model in which TgESPs regulate aerobic glycolysis to promote osteogenic differentiation through the Wnt/Beta-catenin signaling pathway 1499 51176 4041 4040 3099 3939 860 PMC10484181__F3 Potential mechanism of P2X7R overexpression causing tumor progression 4772 4513 383 8205 PMC10484649__F4 Mitogen-activated protein kinase (MAPK) signal pathway in subchondral bone 860 468 1749 PMC10484658__F2 Schematic diagram of ERS in renal resident cells in LN 468 7494 22926 7412 3383 PMC10485805__F1 Intestinal flora regulates tumor microenvironment components 6774 7099 7124 1513 PMC10486691__F6 Association of EN2 with ERBB, insulin, BCR-ABL and JAK signaling 2885 3725 5770 1398 2549 9846 6772 6773 6774 6775 6778 2475 572 4193 9470 4609 867 10580 1399 2889 2670 5292 4170 PMC10486718__F1 Schematically representing the signal transduction and biological activities induced by androgen in ER-positive breast cancer cells 1950 6446 6714 5879 PMC10486718__F2 Schematically representing the signal transduction and biological activities induced by androgen in ER-negative breast cancer cells 1950 7094 6446 5879 6714 4087 4088 5058 PMC10486880__F4 Anti-cancer mechanisms of leeks and their active compounds 9474 10533 2475 581 PMC10487526__F9 Proinflammatory immune response in BV-2 microglial cells induced by NfEVs 7097 6774 3716 PMC10487916__F3 miRNA–mRNA network based on the target genes of miR-141-3p, miR-150-5p, miR-182-5p, and miR-661 (obtained from the Integrated Breast Cancer Pathway (Wikipathways)) 301 5598 79877 57178 204851 6009 1022 4088 1647 1869 2355 6794 10454 4089 5599 4953 659 5879 595 2033 672 5728 7422 657 6772 5597 3667 1605 466 10499 8554 637 4436 2099 8202 1017 596 7035 724031 4193 836 4790 1019 2308 472 580 6667 581 998 1432 28996 25 207 1956 7248 5347 4092 10111 993 7249 6790 PMC10487928__F4 Gamma interactome of the top 20 most connected differentially expressed genes (DEGs), defense response to virus genes, angiogenesis genes, adaptive and innate immune genes, and SARS-CoV-2 proteins 3018 890 983 3024 8345 2048 6622 8359 3728 3008 3958 4171 7039 2064 220972 1969 3556 682 4940 6347 3959 9610 3164 5159 3397 9636 4599 89790 5753 55715 800 PMC10487928__F5 Delta interactome of the top 20 most connected differentially expressed genes (DEGs), defense response to virus genes, angiogenesis genes, adaptive and innate immune genes, and SARS-CoV-2 proteins 53840 8318 27074 117854 84932 2048 5743 10346 64167 4938 4599 79132 26270 3958 3665 5371 9830 5888 2050 9636 8638 983 3433 3434 4940 3315 8335 5347 1514 8359 11113 3018 10112 3437 2633 55601 684 84875 722 83666 8780 665 2150 54625 9582 2635 PMC10487929__F6 Influence of COVID-19 on SNCA expression and PD 1137 1843 4915 6347 6853 4929 6352 2012 3458 59272 6854 7157 10381 5979 8973 10752 972 5950 207 885 183 7124 6772 3665 91543 25 5743 9636 4599 3569 5359 3122 3553 3397 9049 6622 54210 PMC10487929__F7 Network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of SNCA and PD 3553 6352 6622 3458 59272 183 PMC10487929__F9 Network connectivity pathway map of the downstream effects of simulated SARS-CoV-2 infection on the predicted activity of the NISP 6347 6352 3665 3553 6622 7124 3458 59272 3127 6772 183 207 3569 3122 5743 PMC10487929__F10 Network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of the NISP 6347 3458 59272 5743 6352 6622 7124 3553 3569 PMC10488162__F3 The Nrf2 signaling pathway in age-related ovarian aging 5052 6647 847 1728 4094 7018 2879 23411 891 PMC10488162__F4 The Nrf2 signaling pathway in environmental pollutant-related ovarian aging 847 1728 4094 9817 PMC10489316__F9 Details of KEGG pathways of Ras, PI3K-Akt, and MAPK signaling pathway 4118 2885 6010 572 27040 998 367 8036 1610 5879 PMC10489316__F10 Targets-pathways network 25 1636 6868 207 317 367 598 834 836 847 873 6352 998 1017 1021 1508 1509 1513 1514 1956 2066 2099 2100 2147 2246 2260 2263 2932 2936 9446 2950 3162 3320 3312 3480 3558 3643 3718 3791 3934 4312 4313 4314 4318 4843 4846 142 5328 5465 5468 5781 5868 5879 5914 6009 387 6280 6401 6648 6714 6772 7042 7421 331 PMC10489547__F3 Main signaling pathway of cell division cycle 20 homologue (CDC20) in cancers 102466235 100302171 60672 4605 991 29882 7471 89780 27338 51203 7428 3717 6774 6657 891 PMC10492287__F9 The metabolic pathway in placental cells 2805 3099 5214 2806 23428 7462 PMC10493031__F3 Schematic illustration of the CRC-derived exosome mechanisms for CRC metastasis 7852 928 6714 7832 975 58191 387 967 3082 100302142 4087 4088 4089 960 6868 PMC10493031__F5 Schematic illustration of key molecular signaling pathways in metastasis 3082 1956 3845 4909 7852 960 5968 114824 343641 3229 1499 4582 54790 55294 346389 7077 3479 3897 346171 PMC10494486__F7 Signaling model for late-phase IP-10 induction by MRP8/14 in endotoxic mice 7099 3716 7297 6772 3665 2833 PMC10494518__F1 Insulin signaling pathway 3667 2885 5163 2475 867 1398 PMC10495361__F5 Joint analysis of Chinese yew seed transcriptome, proteome, and metabolome 353 1544 5226 1431 847 132 1965 5604 2752 100 1977 978 6209 2107 64223 8454 10855 6500 29128 1788 PMC10495361__F6 Summary diagram of specific metabolic pathways involved in Chinese yew seed germination 2224 2222 9453 48 6389 4026 5662 6120 PMC10495745__F5 Activation of GPCR signaling pathway in macrophages 4041 4040 6352 6347 2932 387 324 5879 998 6772 6774 PMC10495745__F1 Activation of the NF‐KB signaling pathway in macrophages 7099 4615 7186 51135 3654 7189 7187 8772 8717 10454 23118 29110 3661 PMC10495745__F4 Activation of MAPK and TGF‐B‐SMAD signaling pathways in macrophages 4087 4088 1950 1956 2885 4092 64750 10454 387 4089 1386 PMC10497558__F3 BCAAs metabolism in Cancer 587 3845 6850 23409 3479 5163 2475 83939 7398 586 PMC10497558__F6 Aspartate metabolism in solid tumor 3845 6507 79751 3932 10165 440 468 22890 PMC10497558__F8 Arginine metabolism in tumor cells 6541 383 6774 384 PMC10498649__F2 Lipid metabolic alterations induced by oncogenic events and TME cues 948 4609 5728 2746 55902 47 2194 10555 PMC10500222__F1 CELF2 affects ferroptosis through the MAPK signalling pathway 10659 2744 4772 8031 3164 79968 2182 59344 7037 382 2879 23657 PMC10500222__F2 CELF2 affects ferroptosis through the PI3K/AKT signalling pathway 2879 23657 10659 5728 1978 2475 2495 1728 4495 2534 PMC10500222__F5 CELF2 affects ferroptosis via the Wnt/Beta-catenin pathway 10659 5058 4040 2879 4513 1499 PMC10500222__F6 CELF2 is the upstream regulation factor of MAPK signalling pathway, PI3K/AKT signalling pathway, autophagy and ERAD pathway, which can promote cancer cell ferroptosis through these pathways 9474 4772 10659 5728 80243 PMC10501637__F5 PPI network analysis of total DEGs in ELMOD3mut and ELMOD3corrected iPSCs 1268 2920 2587 3827 6372 5443 301 10874 2925 6863 885 6846 1906 1910 2769 6019 70 796 6343 133 58498 7431 6696 3488 5630 4747 3778 54757 255738 1942 53358 2046 8862 183 6376 2914 624 134 554 1944 10161 1131 6247 480 2556 887 2042 1364 2561 5724 491 PMC10502204__F2 ctDNA as a novel and promising approach for cancer diagnosis: a focus on hepatocellular carcinoma 7015 472 545 6125 6135 6137 6201 4041 4040 4193 324 1499 PMC10502988__F8 Following CARNIVAL analysis (or re-uploading previous results) the user can carry out pathway enrichment and visualisation on the inferred signalling network 5566 2064 5290 5293 25 5979 5914 7704 1385 1958 2005 2034 2099 4149 26959 2309 2308 4303 2113 10499 5970 2063 3297 7025 6657 6720 6688 6721 5595 5604 2033 2066 5294 1956 PMC10505163__F9 Hallmarks of severe asthma and the possible role of the identified mRNAs by artificial intelligence methods 5725 7099 4857 4615 5728 2475 PMC10505224__F0 By hindering hnRNPA2B1 from binding to the E3 ubiquitin ligase TRIM21, whose mediated ubiquitin-dependent degradation was thereby inhibited, CRNDE protected the stability of hnRNPA2B1’s high protein expression in CRC 643911 3181 3845 6737 PMC10505339__F1 Interaction of Wnt/Beta-catenin and Wnt/Ca2+ signalling pathways in an inflammatory environment 4041 4040 1499 51701 PMC10505339__F2 NFKB signalling pathway 7124 4050 5971 860 PMC10505605__F1 Extranodal lymphoma: pathogenesis, diagnosis and treatment 2475 355 5728 596 4609 613 973 974 4615 695 3654 51135 84433 PMC10506040__F2 Schematic representation showing downstream signaling events in cross-talk between adiponectin signal transduction and insulin signaling pathway[67] 26060 51094 79602 3667 5728 5163 PMC10506215__F3 PTM of PGK1, including acetylation, phosphorylation, ubiquitination and O-GlcNAcylation 5230 2475 8841 109729180 PMC10506243__F5 Protein-protein interaction network and functional enrichment analysis of proteins with acetylation, carbamylation and phosphorylation sites regulated by bacterial lipopolysaccharide (LPS) 3068 4191 4627 4000 3329 7150 6184 226 5034 81 3183 8539 1973 9097 5230 6233 7317 4602 9188 9031 58508 7431 5903 1655 5902 1642 3615 302 2023 10487 PMC10506410__F1 MTOR Signaling Network (A) Overview of the mTOR signaling pathway (B–D) mTORC1 signaling in mRNA translation, metabolism, and protein turnover (E) mTORC2 signaling function 1956 5163 5728 2885 4763 7248 51256 2932 7249 6009 153129 468 3091 27250 1977 1975 10797 790 7405 8408 7942 2308 PMC10506516__F6 Schematics of proposed pathway for beneficial effects of L-carnitine on lipid parameters 5465 3156 1376 PMC10507829__F1 Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells 22801 3688 857 2013 5578 2534 2909 824 7791 387 81 7408 2316 7094 5170 5829 5728 5747 4659 998 103910 1499 10451 5879 10298 1793 9564 1398 2889 1950 1956 25759 3265 5894 3725 960 2002 5604 6714 2017 2885 7454 369 595 572 596 2549 10000 23365 51196 3708 815 1514 29102 6774 3791 3236 5566 3316 7422 PMC10511911__F5 Regulation of insecticide resistance mechanisms involves epi-transcriptome signals, detoxification signaling pathways, and long non-coding RNAs (lncRNAs) 9817 196 7018 405 100188857 PMC10513492__F7 Lipid and atherosclerosis and (B) AGE-RAGE signaling pathway in diabetic complications map of Chaihu Anxin Capsule for their potential treatment of depression 3661 114609 6402 7124 114548 7054 1958 PMC10514503__F3 S1P protects the intestinal barrier through multiple means 8877 1901 9294 1903 8698 53637 6774 1003 3606 387 PMC10516898__F15 Mechanism of D-TT-BMSCs inhibiting ferroptosis to repair the wound 571 23657 30061 2495 3162 2879 PMC10518103__F9 DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress 7157 79075 3326 6774 PMC10519534__F8 DZP active constituents on myopia through the “AGE-RAGE diabetic complication signaling” pathway 4089 6774 3717 6401 4313 7018 581 1019 PMC10520073__F7 Graphical representation of the regulation mechanism underlying ABC variant rs4810856 and CRC risk 7018 57580 6935 1434 6780 5728 PMC10520679__F3 An illustration demonstrates the involvement of ncRNAs and oncogenic signaling pathways in CRC metastasis 378938 100750225 100652730 5921 406952 5728 2475 302 999 2526 387 10413 27250 PMC10520786__F3 Nrf2 modulates inflammation and apoptosis 9817 581 4513 PMC10520974__F4 Regulatory mechanisms of lncRNAs in cancer cell antigen presentation 6890 6891 3105 811 3106 284930 3107 131405 2146 64167 51752 PMC10521544__F4 Luteolin-target-pathway network 5347 5566 5585 5728 5747 5970 5292 4792 4790 4615 5155 4314 5209 4313 5294 4322 4312 1021 1147 1019 1285 1017 1437 983 1457 959 4193 4170 5601 3627 6387 3576 840 1950 836 958 595 5599 5595 54627 85417 9133 834 6885 3791 2810 1956 598 3727 6352 6517 1958 842 6348 3725 596 6347 6714 581 6850 29110 7040 7099 2064 355 3091 3162 7124 329 847 3567 8743 8626 7161 3383 238 3456 207 3458 196 3480 59 177 3553 3596 7422 7423 2354 7450 2247 3562 3565 PMC10525272__F6 Platelet activation pathway confirmed in the KEGG pathway analysis 7450 387 2147 5624 1610 7408 4067 2534 6850 2444 1311 8773 PMC10525645__F2 Simplified scheme for the conversion of food-derived copper into biovaluable copper 475 538 213 1356 540 6647 10063 PMC10527059__F4 Predicted function of miRNAs interacting with circPSEN1s is summarized in this picture 100422874 25825 114804 5757 125111 4087 4088 3619 64960 126374 4089 7046 26524 1874 3400 3399 3398 PMC10527795__F1 Wnt signaling pathway 1499 4920 4041 4040 324 5879 998 6010 PMC10530616__F15 Schematic illustration for the effects of Actinidia deliciosa (kiwi) extract on pathways related to T2DM 5728 5163 572 2932 6774 23411 9817 847 PMC10531058__F2 SIRTI 1 pathway 693164 283120 55384 407040 23411 100126335 84973 2308 PMC10531058__F4 TGFB pathway 440823 55384 25805 PMC10531058__F5 Nuclear factor erythroid 2 related factor 2 (NRF2) pathway 378938 9817 6657 55384 PMC10531837__F4 Phenotype switching in melanoma 4286 3662 1638 5077 6663 6591 9839 4162 55553 6662 358 7021 4804 6660 6657 27022 6935 5054 6615 558 2335 6925 7291 2191 3725 1956 PMC10536424__F3 Anti-cancer mechanisms of PDE5 inhibitors 4843 383 595 2475 PMC10537408__F8 miRNAs in the HSV-2 infection of macrophages 3586 7297 3716 581 207 857 6654 2885 2475 PMC10542959__F3 FOXM1 is involved in regulation of diabetes-related inflammatory responses 4088 2475 3458 7124 2305 6376 PMC10544979__F8 The MyD88 and TRIF signaling pathways and downstream responses by the protein-based adjuvants rSIP and FLH in APCs 7099 4615 941 942 324 PMC10545718__F1 Bioactive lipid-mediated regulation of insulin downstream signaling and lipid metabolism in adipocytes: mechanistic overview 3667 5140 7038 948 5465 1384 5163 PMC10545798__F8 Cholesterol affects tumor cells by modulating immune responses, ferroptosis, tumor cell stemness, and the DNA damage response 948 3717 6774 2879 3652 3156 10162 2224 23613 PMC10546379__F7 SIK2 on Wnt/Beta-catenin signaling pathway 4040 23235 23035 3417 PMC10548138__F1 Transduction and regulatory pathways of PI3K/Akt pathway 8821 5728 5163 5164 PMC10550586__F4 Representation of the KEGG TNF Signaling Pathway, showing up-regulated (red boxes) and down-regulated (green boxes) genes 7124 8772 329 83737 8837 4293 257397 2353 7186 1051 602 468 9530 4790 4792 1147 2919 6372 1435 1437 355 182 3553 4049 7185 3726 3725 4314 4323 4318 1906 2277 64127 11035 197259 6401 3383 5743 7187 PMC10551897__F13 KEGG pathway diagram for MAPK signalling pathway 2885 6722 7054 7124 8717 7186 355 1616 4149 929 23118 7189 51295 PMC10551897__F8 SX Components-Targets-Pathways Network (Green hexagon node shows SX, pink diamond nodes show the components, blue rectangle nodes show target genes, orange ellipse-shape nodes show pathways and edges show the interaction between two nodes) 2322 1017 367 3717 5747 3320 2247 5734 5777 2321 5743 841 836 2033 5347 5578 994 2475 7157 1436 3815 2246 983 6790 5581 1956 2064 3791 207 4193 6714 PMC10552500__F3 Nutraceutical-mediated signaling pathways underlying some neuroprotective processes 102 351 23621 581 4803 627 4513 PMC10552782__F2 Regulatory Mechanism of Iguratimod on Signaling Pathway (IFN, interferon; TNF, Tumor necrosis factor; IL, Interleukin; Th, helper T cells; Treg, Regulatory T cells) 3569 3458 3725 1749 7124 920 1958 PMC10555535__F1 Metabolic pathway of exogenous and endogenous lipoproteins 348 3949 4023 PMC10555542__F4 Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial 83667 196 51141 5284 581 28999 9958 139596 8773 2033 5728 57381 55023 596 5290 2885 2650 10890 2297 5332 6616 3156 1398 8202 7422 2099 5786 6844 3845 1906 595 1285 PMC10556387__F1 Neuroprotection targeted to oxidative stress and induced mitochondrial dysfunction and ferroptosis in ischemic stroke 9817 10162 2879 4015 2182 PMC10556387__F2 Neuroprotection targeting to signal transduction of apoptosis, necroptosis, and autophagy in ischemic stroke 54822 8772 11035 8737 637 197259 5163 581 22863 PMC10556522__F1 Pathogenic signaling pathways in ALK+ ALCL () represents deregulated T-cell receptor signaling pathways mediated by NPM::ALK 8205 3932 2534 3702 56940 51744 29851 962 572 2475 47 6713 238 6774 3066 4436 3065 4204 1786 4437 6772 3574 3569 3586 3578 3596 3565 5008 50616 112744 55801 149233 2625 51176 64919 100126333 PMC10556522__F2 Genomic rearrangements that contribute to pathogenesis of ALK- ALCL () represents ALK- ALCL harboring DUSP22-rearrangement and associated signaling pathways 965 4609 10320 3662 51741 2066 55509 639 29123 8085 79718 56940 6098 9612 4791 PMC10558228__F1 NFKB signaling pathway and targets of inhibitors against neuroinflammation in AD 51094 929 7099 4615 7189 7124 PMC10558228__F4 PPAR, STAT3 and PI3K/Akt signaling pathways and targets of inhibitors against neuroinflammation in AD 5728 3717 6774 7124 PMC10559873__F6 Detail of pathways 5053 6401 3717 920 8772 7054 7124 4513 6280 3934 9365 2444 PMC10559929__F5 Explain the correlation among the chemical components, candidate targets, involved pathways and corresponding pharmacological effects of AGNHW 6647 3481 857 142 3162 9429 4282 2950 3627 1786 4318 3055 873 6772 1051 3383 301 5294 5970 596 5328 5602 836 7124 PMC10559930__F1 Mechanism involved in ZNF703 including the signaling pathway, upstream regulation network and downstream targets 80139 1364 2475 999 10238 9612 1869 5925 PMC10559995__F1 Signaling Pathway of Estrogen Receptor 1950 8205 1956 10395 7018 PMC10561274__F2 Inflammation associated signaling activated by fractalkine 6376 1524 5163 9817 7124 PMC10562563__F1 Toll-Like Receptors (TLRs) signaling pathways, intra-, and inter-signaling crosstalk circuits, and their regulatory loops 7097 7096 114609 4615 3654 51135 7189 10333 7100 7099 23118 257397 7098 51284 54106 51311 7187 29110 3661 3458 PMC10564423__F8 Schematic diagram illustrated how core fucosylation regulated alveolar epithelial cells senescence in pulmonary fibrosis through TGFB/Smad2/3 pathway in vivo and in vitro 641 4087 4088 999 PMC10565042__F1 Diverse types and molecular mechanisms of the Wnt signaling pathway 6259 5879 23002 387 1499 324 9475 998 PMC10565042__F2 Involvement of ncRNAs in modulating the Wnt signaling pathway in prostate cancer 100302203 574473 324 1499 6259 347689 388796 85028 79854 23642 154822 641518 101927992 PMC10565042__F3 Wnt signaling pathway-related ncRNAs in the regulation of invasion and migration in prostate cancer 55000 347689 79854 101805488 85028 324 11063 57447 6422 7090 85407 7922 6934 3149 7855 85458 1499 55366 960 2535 5879 100302203 574473 2146 23642 641518 154822 647979 PMC10565042__F4 Wnt signaling pathway-related ncRNAs in the regulation of EMT, apoptosis, stemness, and CRPC formation in prostate cancer 647979 100506311 154822 7922 8766 51176 1499 324 641518 101927992 388796 6422 960 2535 PMC10565453__F2 Organelle-level mechanisms of mitochondrial quality control 51024 56947 4976 7054 23411 25886 4899 PMC10565453__F3 Altered mitochondrial quality control in renal tubule cells under high glucose conditions 4899 7019 23241 10628 283131 23410 65018 11331 55586 192111 7852 6774 51024 55669 4976 2475 PMC10568034__F2 Manner in which the studied product acts on the Wnt pathway in lung cancer 7018 324 1499 PMC10568316__F1 Multifunctional role and mechanism of IMφs in NEC pathogenesis 7124 3479 383 6374 650 PMC10570508__F2 PITX1 acts as a core gene that regulates the p53 signaling pathway 7027 1869 5300 7536 5307 PMC10570830__F2 PIFs are the key regulators of skotomorphogenesis 1642 64326 55070 51411 PMC10571545__F5 TF–FVIIa–driven PAR2 activation triggers EV generation from human TNBC cells, which promotes EMT in non–metastatic breast cancer cells, leading to the induction of proliferation, migration, invasion, and anti–apoptosis 999 1000 5728 PMC10571577__F1 HGF/c-MET signaling pathway 3082 4486 4919 960 1956 2549 2885 1499 6774 2475 PMC10571651__F1 Normal physiologic MET receptors form dimers upon HGF signaling, and Cbl binding leads to ubiquitination 867 6714 2549 3082 2885 PMC10571700__F5 Gene expression (CAMs) 1000 1001 920 3696 917 915 6693 3383 3684 940 29851 57689 29126 1493 4897 5133 923 4685 6403 925 201633 6900 26047 1272 919 916 27040 3932 4794 7535 5293 10000 1956 1950 3458 2353 9369 9379 4773 238 55509 116071 PMC10571764__F1 Therapeutic mechanisms involving elotuzumab and Anti-SLAMF3 in multiple myeloma (MM) 1445 57823 7018 2885 PMC10571814__F8 Oxytocin signalling pathway, with yellow boxes representing proteins identified in this study and green circles representing metabolites identified in this study 1956 5020 2982 784 952 7226 387 389 6714 5567 10398 5604 63891 673 26509 1938 51806 7125 9499 29904 7134 84033 4633 29895 4632 4634 4635 9201 85476 140465 1028 100137049 123745 5997 4513 1827 4208 595 PMC10571979__F8 Norrin signals through DVL1 to stimulate barrier properties 23554 8322 4041 4040 7122 1855 1365 PMC10572085__F2 Signaling pathways of the CD44 intracellular domain (CD44-ICD) under hypoxia 960 11319 860 6657 79923 595 5163 5210 PMC10572085__F3 Signaling pathway activated by HA-CD44 interaction 960 5879 6010 998 2064 1956 PMC10572085__F5 HA-CD44 binding-activated signaling pathways 960 79923 6657 596 PMC10572209__F7 Molecular pathways in Hep3B cell line 619501 5728 572 1019 2922 7975 3630 PMC10572466__F6 Schematic drawing illustrating the action mechanisms underlying the effects of baicalin on cytoskeleton rearrangement induced by PVL in BMECs 9475 3985 3984 387 PMC10572524__F7 DEGs in NOD/Toll-like receptor signaling pathway 64170 4671 7099 7100 3661 10379 2920 6773 PMC10572663__F2 Signaling pathways regulating EMT 1950 3082 6469 50846 3549 6608 324 4087 4088 4089 1499 2475 51176 3725 2736 2735 6615 6935 7291 PMC10572708__F12 Lipid and atherosclerosis metabolic pathway 9241 572 958 6774 3929 929 114609 4703 6403 6401 3416 10010 3661 5183 338 4067 100187907 84693 257397 4015 6955 7124 10529 836 581 PMC10573127__F1 Airway epithelial differentiation pathways 8626 3852 286887 3861 3866 3851 3860 3868 25984 7356 117156 25803 4586 727897 166979 10309 159989 121643 1080 4602 5991 5990 7161 4803 PMC10573127__F3 Secretory cell (SC) differentiation programs 647309 4610 100188776 1080 345643 3596 860 2305 25803 7356 3170 6439 653509 6441 362 6338 688 6340 9314 4586 143662 10551 3171 1179 5733 PMC10573607__F4 Soluble sugar, cellulose, and lignin contents 3725 790 1312 79192 PMC10573612__F2 Exploring the Cellular and Molecular Mechanism of Discoidin Domain Receptors (DDR1 and DDR2) in Bone Formation, Regeneration, and Its Associated Disease Conditions 780 4921 5728 6010 4133 PMC10573925__F1 Effect of sclerostin on the Wnt/Beta-catenin pathway 4041 4040 1499 324 PMC10578286__F1 Insulin signaling pathway schematic 3630 3667 5728 5163 PMC10584331__F1 Ferroptosis mechanisms 100 8031 10162 4015 2936 2879 PMC10584331__F2 Reverse of liver fibrosis by inducing ferroptosis by bioactivated compounds in HSCs 7018 26291 8314 2879 7538 8031 2937 2936 PMC10586346__F3 Osteogenic differentiation-related signal pathway diagram 1499 59272 1834 860 PMC10586807__SF3_1. Correlation between CRISPR KO and CRISPRa screen gene hits within certain pathways 7124 8837 5594 8737 7132 3383 64422 5289 2475 83734 9776 89780 595 8945 8312 84962 5771 8651 3717 6772 PMC10603888__F10 Signal path analysis: (A) thyroid hormone synthesis (Calcium ions within the cell are transported outside the cell via the transmembrane, as indicated by the red boxes 7276 7054 8458 7253 1610 7038 7173 50506 2936 PMC10603981__F1 Signaling pathways involved in ferroptosis 6520 23657 2879 31 2182 2194 8878 26471 PMC10603981__F2 Necroptosis signaling pathways 355 8737 8772 3466 7098 81030 11035 8717 7186 142 197259 PMC10604135__F6 Mutated proteins in four patients colored with red, green, cyan, and brown with arrangements of their roles on Wnt and mTOR signaling pathways 11197 999 1499 203522 285362 3423 2250 60 2316 8239 7248 7249 6194 1977 27330 PMC10604560__F3 Lipid metabolism 948 5465 7124 4018 47 2194 79071 7038 PMC10604974__F2 Autophagy in viral infection 2475 64422 10533 8408 9706 57762 60673 9776 55626 22863 83734 9140 9474 PMC10605176__F1 Neuroprotection by the volatile anesthetics sevoflurane and isoflurane 6667 2932 7099 3717 6774 PMC10605176__F3 Noble gas-induced neuroprotection 581 7097 7099 6647 PMC10605634__F1 Tumor intrinsic factors related to immune evasion and ICI resistance 2932 1499 3716 3717 3659 324 567 3105 3107 3106 84166 4089 3902 PMC10607277__F9 Compound–disease–therapeutic targets-core pathways network; red triangles represent diseases, blue triangles represent compounds, purple ovals represent pathways, and green ovals represent targets 3717 2932 5879 5970 598 5747 3320 1019 4314 2308 4846 4312 3553 2099 596 3066 3312 9261 5579 3326 1017 PMC10607347__F3 The anti-apoptotic action of MSCs in the hepatocyte–MSC co-cultures 581 637 3099 5292 5728 2475 3082 9242 PMC10608541__F13 Pathways and localization of astaxanthin biosynthesis and esterification in Haematococcus algae 3652 355 8694 84649 PMC10608708__F7 Mapping of the top targets in the PI3K-AKT signaling pathway 6009 7249 2885 2475 613 6850 930 5728 1977 1975 4609 5934 572 6256 PMC10610064__F1 ABL Kinase Activation and Signaling in Solid Tumors 1600 7204 25 27 7852 6714 2475 595 6010 10006 1728 PMC10610100__F2 Protein–protein interaction (PPI) network map of the KEGG enriched signal pathway of differential genes 4129 2328 2326 2878 2687 64399 367 4852 2353 7010 7432 2977 57121 5465 183 5880 5997 3937 2516 5593 10846 10636 55740 PMC10610204__F4 Activation of DNA damage-induced checkpoint signaling pathway in ATM-deficient cells and mechanism of ATR inhibitor and ATM defect-induced synthesis and lethality (by Figdraw) 472 84126 545 993 995 PMC10610204__F5 WEE1 and TP53 synthetic lethal interaction mechanism (by Figdraw) 6741 472 545 7465 1017 983 PMC10610499__F5 Interplay between EVs and the TLR4 signaling pathway in the context of HCC 7099 619501 25859 3146 7097 6281 1956 PMC10620831__F8 PRMTs regulate antiviral innate immunity 3275 7099 10196 3276 54496 90826 10419 115004 57506 3428 7189 29110 3661 84166 55170 PMC10622988__F4 Tumor-associated signaling pathways influenced by lncRNA SOX21-AS1 in breast cancer, lung adenocarcinoma, and glioma 1499 4771 100507533 595 23286 7103 4485 26524 PMC10622993__F2 Common signaling pathways and ALDH1 expression in CCA 4041 1956 324 1499 2932 7046 4089 2475 999 10682 4088 4087 1000 PMC10623083__F7 CFH knockdown suppresses the stemness of breast cancer cells through regulation of the EPB41L3/MAPK axis 23136 3075 100133941 960 6657 4072 4810 PMC10623085__F7 Proposed signaling pathway by which NE mediates HepG2 cell proliferation 5163 6009 7248 7249 PMC10625490__F2 HIV infection induces intestinal mucosal barrier damage and immune cell dysfunction, which aggravates the inflammatory response 7099 7124 3458 PMC10631767__F2 Associations between CCA, TAMs and TANs 6774 7422 3586 3589 5008 PMC10635689__F8 BJ-5ta Exo exert a protective effect against UVB-induced photoaging 7040 4513 5888 PMC10644365__F2 Signaling pathways associated with ERA 2475 5728 6009 5163 2885 324 1499 7248 7249 2202 7018 PMC10647353__F2 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis 64840 1499 324 6662 204851 10927 6657 PMC10647460__F7 Regulatory mechanism of cis-9, trans-11 CLA on milk fat synthesis 5468 9474 3162 PMC10647618__F1 Canonical Hedgehog Signaling Pathway 6608 51684 2932 156 PMC10647767__F1 Developments in Genetics: Better Management of Ovarian Cancer Patients 472 2177 675 5888 672 11200 PMC10647767__F5 Developments in Genetics: Better Management of Ovarian Cancer Patients 6774 595 4313 216 4318 1499 79923 1000 999 PMC10648005__F1 Main molecular consequences of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway activation 5728 2308 5163 2475 PMC10648512__F3 Effect of exosomes derived from glioma stem cells and containing miR-26a on the BBB 145258 5163 2475 5728 PMC10648520__F8 Brief Review of Bone Cell Function and Importance 4041 4040 1499 PMC10648679__F1 PSCs have emerged as a promising candidate for stem cells in PDAC 100653366 1499 3481 PMC10649278__F6 Diagram of IL-17 signaling pathway 920 7054 8717 8772 100187761 4117 4513 10129 PMC10649670__F6 Central illustration 7857 652 2277 7494 6347 1232 3690 79924 6369 3579 5228 2833 6678 7057 9510 56999 3627 PMC10650070__F2 NFKB, MAPK and Oct-1 pathways for expression of Beta-defensins 4049 4615 7097 PMC10665998__F6 Long non‑coding RNA PEG13 regulates endothelial cell senescence through the microRNA‑195/IRS1 axis 3667 359809 4193 7412 3383 PMC10669195__F1 Unleashing the Potential of Nrf2: A Novel Therapeutic Target for Pulmonary Vascular Remodeling 9817 6256 9978 1004 4094 PMC10669226__F3 Cardiac Hypertrophy Signaling pathway is predicted to be upregulated in EVPs from aged animals 3479 3569 6010 10454 2885 3667 2475 6198 9261 6195 64100 3725 6722 2002 1386 159 PMC10669528__F4 Process of GSDMD in the pathogenesis of systemic onfection 59272 9447 7018 79792 929 100187907 PMC10669584__F1 APE1/Ref-1 role in inflammatory bowel disease and the potential of redox signaling inhibition 7099 6774 7018 PMC10669635__F2 PI3K-Akt signalling pathway 5728 5163 4193 PMC10669635__F3 Partial epithelial to mesenchymal transition (p-EMT) and full EMT with associated biological markers 999 1499 1000 PMC10669822__F6 “PPAR signaling pathway” was an upregulated KEGG pathway for the transcriptomics profiling of HMEC-1 treated with MPE (0 5360 1543 4023 4973 4312 7350 3611 7316 364 PMC10670187__F1 LncRNA MIR4435-2HG is involved in signaling pathways for cancer progression 541471 1832 128239 113130 1499 4087 2475 999 1000 6615 4318 PMC10670414__F8 Anticancer Effects of 6-Gingerol through Downregulating Iron Transport and PD-L1 Expression in Non-Small Cell Lung Cancer Cells 1956 3717 6777 581 8011 55240 PMC10670481__F6 Analysis of KEGG pathway and interactive enrichment networks 5140 200186 108 3276 2695 5836 2147 11113 5315 PMC10671144__F3 Upstream regulator analysis of cisplatin revealed the upregulation in FAS, PRKCA, and CDKN1A, and involvement of tumor microenvironment pathway (lung adenocarcinoma (LUAD) [lung] cisplatin 9800) 1356 467 1647 8493 7508 6232 26256 7832 PMC10671144__F7 Network analysis of oxaliplatin revealed that oxaliplatin as a master regulator was predicted to be inhibited and the SPINK1 pancreatic cancer pathway was inactivated in ischemic cardiomyopathy 8786 1356 8878 6690 7040 5651 7048 2150 7046 1208 5644 5645 PMC10671441__F2 Wnt Signaling pathway 1499 324 10297 8312 11197 2011 11184 10454 6885 8945 4193 1029 7157 10856 51701 2494 3725 595 6925 6927 4609 5467 22943 6422 8313 960 PMC10671441__F4 IPA Core analysis of the Epithelial Adherens Junctions Signaling in SW480 AHCY deficient cells with increased expression of LEF1 protein 4301 9855 1398 9828 387 340719 89797 1956 1894 2909 6794 8826 10097 10458 7454 8936 9863 5728 7414 999 7074 2534 2241 10413 4771 1950 3082 3480 2246 2260 7042 1000 10009 6615 6591 PMC10671441__F9 Human Embryonic Stem Cell Pluripotency Signaling 3976 2247 2249 406937 6926 1855 79923 55211 4609 7015 4838 2103 5978 PMC10671474__F1 Current endocrine and targeted treatment of metastatic ER+ breast cancer 1019 1021 2475 PMC10671516__F3 Granulosa cell glucose and lipid metabolism on oocytes 9973 3939 3945 123 PMC10671577__F3 MAPK signaling pathway containing T 1147 3925 1950 1956 673 2254 2885 4351 2002 6722 5156 4342 5801 10000 7124 7186 355 1616 4149 929 10766 51295 994 PMC10672284__F1 Multifaceted functions of (AMPs): (A) Depiction of the signaling pathway involved in Gram-negative bacteria-induced infection caused by lipopolysaccharides (LPS) 3929 4615 51135 7124 114609 PMC10672974__F13 Recent Advances in Drug Discovery for Triple-Negative Breast Cancer Treatment 5163 3667 5728 2475 PMC10675221__F2 Results of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis 2475 5328 1111 9133 2147 5777 994 240 891 695 4322 983 142 4314 5054 1017 331 836 3558 1019 3932 596 1759 4914 598 3569 7099 5743 2534 5601 6850 114548 9020 4804 207 8767 4312 5321 4193 3716 5335 4170 1268 1432 834 4843 5600 6097 5602 3791 2064 3091 5580 5290 3320 6772 5781 5771 3676 5970 6778 5595 3689 3480 4318 5159 1956 2321 5170 5515 3725 6774 673 3123 7124 3685 5770 208 2099 6198 2932 6714 2100 3690 1374 1080 3156 1909 3066 890 3065 8841 2168 25 3718 4313 5578 1586 3702 6258 3643 3717 6256 5291 6257 1234 9475 10499 5241 2167 PMC10685161__F1 Major UPR pathways initiated from the ER and the potential role of AGR2 in interacting with EGFR and MUC2 22926 83939 7494 468 10551 7186 4583 1956 PMC10685161__F2 Role of AGR2 as a critical regulator of maintaining intestinal barrier function by affecting the intestinal goblet cell differentiation, maturation, and secretion of MUC2 474 2672 25803 1950 4583 10551 1956 PMC10686715__F2 Exosomes from different MSCs mediate PCD in myocardial cells after myocardial infarction 5728 9242 55240 2475 581 9474 7187 114548 PMC10686715__F4 Angiogenic effect of exosomes released by different MSCs after MI 3082 100302142 7054 11098 1944 9242 PMC10686798__F1 Wnt/Bcatenin signaling pathway 4041 4040 8549 55366 54894 84133 324 1499 PMC10704547__F1 AhR ligand-activated pathways mediate anticancer activities in breast cancer cells 1019 196 405 6659 4851 1543 1545 581 1544 PMC10704547__F2 AhR ligand-activated pathways mediate pro-cancer activities in breast cancer cells 6999 8942 5053 4313 196 1543 1499 595 5728 10013 6777 4318 405 154075 10682 5971 1545 PMC10704547__F4 AhR ligand-activated pathways/genes exhibit anticancer or pro-cancer activity in breast cancer cells 9049 196 9314 405 57491 595 4318 4313 182 581 7852 6659 PMC10705325__F13 Study on the Effect of Oleic Acid-Induced Lipogenic Differentiation of Skeletal Muscle Satellite Cells in Yanbian Cattle and Related Mechanisms 5360 4023 4312 7350 3611 7316 364 PMC10705747__F6 CBD’s neuroprotective mechanism in ABeta-induced impairments 2896 5336 7001 1075 56833 627 2668 PMC10705753__F1 Illustration of semaphorin 6A–D signaling pathways and their interaction with the cellular molecular network in cancer cells 11319 10501 10500 80031 5465 6925 6591 6714 387 6774 9839 4851 2260 6935 3280 2791 1499 595 PMC10705753__F3 Illustration of the mTOR–Sema6D–PPARG signaling pathway in controlling macrophage polarization toward anti-inflammatory (antitumorigenic) phenotype M2 via regulation of fatty acid uptake and metabolic reprogramming 80031 948 2167 7124 383 5468 PMC10705939__F2 Schematic diagram of the regulatory pathways of K+ channels or transporters in Arabidopsis and rice 208 9530 83933 PMC10706418__F5 Analysis of hormone signaling transduction in response to CGMMV infection 108348016 7018 64641 1879 578 51411 4881 PMC10706592__F1 TRAIL signaling pathway 581 331 8772 637 PMC10706592__F3 TRAIL signaling pathway indicating the therapeutic targets modulated by flavonoid compounds 637 8772 331 PMC10706690__F6 CPNE7 study schema related to EMT 999 1277 27132 4313 4314 1000 6935 PMC10707303__F5 Fibrotic factors in the development of DKD 7490 6772 1636 4313 PMC10708062__F8 Analysis of DEGs involved in carbon fixation under osmotic stress 6120 22934 4191 PMC10708062__F10 Analysis of DEGs involved in citrate cycle pathway in roots under osmotic stress 5091 5162 4190 4191 6389 6391 6390 47 1431 3417 3418 4967 PMC10708146__F2 GSDMD-mediated pyroptosis in DCM 7099 4615 3661 57721 115004 9447 9968 114548 23410 79792 440823 PMC10723546__F3 Biological pathways in ccRCC 6595 8289 6597 5931 23512 55193 196528 8726 2146 65980 29072 5728 7249 1029 472 545 3091 6146 55294 2475 1387 10868 7157 4193 4194 3845 405 2033 6921 7428 673 29128 5741 5604 5605 7345 PMC10725447__F0 Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/Beta-catenin signaling activation 324 5163 113828 1499 PMC10728021__F5 Proposed combination treatment strategy to tackle p53‐mutant esophageal squamous cell carcinoma (ESCC) tumors with a WEE1 inhibitor 6118 7465 472 545 983 PMC10728906__F4 Inflammatory activation of astrocytes and microglia by Alpha-Syn and phenotypic switching between astrocytes and microglia 2475 114548 4615 7124 6376 6352 PMC10728939__F3 Signaling pathways regulated by BAMBI 929 7046 4041 4040 7099 25805 4615 7189 4087 4088 324 4092 4089 3383 7412 6925 PMC10740436__F3 Comparative Serum Proteome Profiling of Canine Benign Prostatic Hyperplasia before and after Castration 367 5284 1855 7316 2932 1956 10188 998 2885 9564 10023 PMC10740511__F4 Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer 4851 113878 8650 1487 9612 4855 22938 84441 196403 4853 2648 3714 11317 2033 4242 1857 8850 5664 1856 494334 23220 55534 151636 100847014 3066 388585 5663 182 10683 9253 3280 1840 1387 PMC10740567__F1 Signaling pathways involved in the inhibition of apoptosis by Apicomplexan protozoa 7124 8717 7186 8772 637 1956 6774 317 581 PMC10740672__F10 Oncogenic signaling pathway plays a crucial role in tumor suppression in vivo 545 472 4193 PMC10740933__F3 (Left) Initial biosynthetic pathway for the formation of a lipofuscin fluorophore A2E in photoreceptor outer segment (OS) and its structure as a component of lipofuscin (LF) in the RPE cell 545 6120 4827 PMC10741130__F6 Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer 3082 7248 7249 572 842 4193 999 595 1977 PMC10741569__F1 Viruses modulate the EGFR signaling network 1956 7425 10247 PMC10741648__F1 Reelin signaling pathway 7436 1600 6714 1398 1399 5163 PMC10741662__F1 WNT/Beta-catenin signaling pathway 999 147495 4041 4040 324 1499 PMC10741690__F2 Mitophagy pathway 10133 65018 8887 55626 664 139341 PMC10741975__F5 Compound-pathway network has 41 points and 151 lines 2475 2932 1019 6778 9020 1513 3718 5290 5601 2833 5293 1232 5291 729230 4217 7124 PMC10741975__F7 Chemokine signaling pathway and PI3K-Akt signaling pathway influenced by esaxerenone 1950 3718 729230 1232 5293 6714 1026 1027 1017 3569 3570 1956 PMC10742113__F1 Comparative signaling pathways mediated by adiponectin, leptin and resistin 51094 79602 3953 3717 6774 7099 9021 3569 7412 3383 5443 181 PMC10742113__F2 Comparative signaling pathways of IL-6, PAI-1 and MCP-1 3717 9021 6774 729230 PMC10742113__F3 Signaling pathway mediated by Escherichia coli lipopolysaccharides (LPSs) 3667 4615 7189 7099 7124 355 7412 3383 PMC10742113__F5 Bacterial degradation of trimethylamine (TMA) for trimethylamine N-oxide (TMAO) formation 2326 2328 114548 55364 PMC10742340__F1 Molecular signaling pathways associated with Mn neurotoxicity 581 5728 5163 23411 627 65018 115004 6009 83939 3717 6774 3661 114548 7124 3606 PMC10742473__F4 Canonical and alternative signaling pathways in B-cells 613 4067 29760 6850 695 5336 930 3055 5880 2475 PMC10743592__F2 Presentation of the action of ghrelin on autophagy 2475 9776 8408 9706 260431 PMC10743660__F1 Key molecular events of EMT 999 1499 1000 PMC10743660__F3 Nexus of Inflammation-Induced Epithelial-Mesenchymal Transition and Lung Cancer Progression: A Roadmap to Pentacyclic Triterpenoid-Based Therapies 3479 3082 3146 3480 302 6714 4615 7099 6387 7852 5728 5976 324 1499 4088 4089 4087 PMC10743660__F4 Immune component of inflammation-induced EMT in lung cancer 4088 4089 4087 999 3570 3717 6774 6347 729230 PMC10743660__F6 Inhibition of inflammation-induced EMT by PTs 4041 4040 3146 7099 1956 1950 4615 7189 324 1499 4087 4088 5163 6010 6502 9978 6500 8454 4089 999 57154 3717 11346 2475 6774 1000 7076 PMC10743660__F7 Inhibition of stemness by PTs 64220 1956 1950 6502 5163 9978 6500 8454 5914 324 1499 216 3717 6774 79923 6657 PMC10743675__F4 Bone morphogenetic proteins (BMPs) signaling pathways 654 353500 653 7040 7042 7043 10220 2660 3626 83729 60 3625 3624 3623 650 652 4838 2658 27302 659 860 9518 2662 2661 22943 50964 5741 4041 4040 324 5745 PMC10744232__F3 Pomegranate (Punica granatum L.) and Its Rich Ellagitannins as Potential Inhibitors in Ulcerative Colitis 7124 3554 2475 6774 6194 PMC10744266__F1 Action of warfarin relevant to pharmacogene identification (further details provided in the Data Supplement) 348 5005 5243 8529 1559 1576 1548 1543 79001 2052 5212 2677 813 1728 PMC10744281__F1 Interconnection of glycolysis with other metabolic pathways 1950 3099 11113 5210 5209 7248 7249 6009 2475 4199 4190 3156 3417 4191 2194 3418 2271 PMC10744281__F3 Apoptotic process by glycolysis and lipid metabolism in glioma 8772 637 3099 581 596 2194 PMC10744281__F4 Autophagy by glycolysis, lipid metabolism, and glutamine in glioma 5209 3156 1950 84335 2744 7248 7249 6009 3099 2475 8877 23411 3091 596 8408 2194 664 9706 83734 10533 3939 7942 5230 PMC10745105__F6 Working model of GAH-dependent vascular repair 4093 4086 4090 331 10454 4089 PMC10748092__F2 Colorectal Cancer Stem Cells and Targeted Agents 960 8549 100133941 4072 6774 2475 1499 79923 6657 6608 PMC10748332__F5 Signaling pathways involved in neuroprotective mechanisms 2309 2475 27068 7124 PMC10749620__F2 NRF2 peptide with its seven Neh domains and their roles 9978 8452 9817 6256 4094 PMC10749620__F3 KEAP1-NRF2-ARE pathway 9978 8452 9817 4094 PMC10749620__F4 KEAP1-NRF2 by P62 non-canonical pathway 9978 8452 9817 PMC10750287__F6 Molecular mechanisms of autophagy triggered by excess Cu 538 540 6647 475 9973 9817 2475 8408 10063 9997 6341 2147 PMC10758056__F8 NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway 84126 545 983 11073 PMC10758146__F1 Lithium exerts neuroprotective effects in ischemic stroke through multiple mechanisms 1499 114548 627 2475 PMC10770036__F0 Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer 115004 3661 29110 567 3627 6352 PMC10770335__F3 Regulation mechanisms of KCC2 in mature neurons 627 5335 130497 4087 PMC10778012__F5 tRF-mediated translational regulation 4553 4904 6234 1977 3714 PMC10778111__F3 Non-coding (nc)RNA-regulated signaling pathways involved in gastric cancer invasion 6010 1956 22943 4087 324 4088 998 2475 4089 PMC10778261__F8 Modulation of PI3K/AKT/TORC1 signaling pathway and AMPK activity downstream of M2 mAChR activation by APE or N8 in U251 and GB7 cell lines 2475 8408 5163 PMC10778290__F7 Schematic diagram shows that tumor-derived ESM1 combines with the c-Met expressed by endothelial cells to promote GC peritoneal metastasis by inducing angiogenesis 7422 3091 4318 11082 PMC10778515__F6 The Rap1 signaling pathway 2246 2885 4803 3791 4893 PMC10778571__F3 Pathways regulated by DKK-3: insights into DKK-3 functions 4041 4040 10970 27122 324 4920 PMC10778705__F3 cGAS-STING antitumoral and protumoral mechanisms 115004 29110 3661 64761 6774 PMC10778733__F3 Visualization of CAC-related genes and their functional cross-talks 54472 6404 2932 5004 5970 2908 8841 4843 8517 4804 4908 6774 9020 4318 6622 7124 7448 1147 4790 7157 114548 9451 330 729230 25797 4052 6523 3192 1636 5340 7099 4638 826 6403 3486 374 23411 29123 5054 154 5468 823 6272 3551 5327 2778 PMC10778733__F7 PPI is related to adipocytokine signaling 5468 154 4843 PMC10779012__F1 Metabolism of cholesterol within an ovarian cancer cell 3931 19 9619 5174 3949 6713 2222 3156 22937 51199 PMC10779012__F3 Mechanisms by which pitavastatin and metformin act to (A) turn cancer cells sensitive to chemotherapy and (B) help to revert the exhaustion state of CD8+ T cells 3156 2475 920 PMC10779100__F1 Regulation of osteoclast formation by MERTK and TYRO3 2621 7301 5627 10461 387 PMC10779100__F2 TAM receptors and their downstream signaling pathways in osteoblasts 8205 3479 2621 5627 558 3480 7301 3667 387 22943 10461 7410 3717 1499 2932 324 PMC10779133__F1 Ketogenic and ketolytic pathways in the liver and brain cells 38 3158 622 3155 1431 PMC10779133__F3 Signaling functions of KBs and KD for anti-apoptosis, antioxidant defense, and epigenetic and post-translational modifications 2308 50507 7351 6648 2539 627 PMC10779133__F4 Signaling functions of KBs and KD for anti-neuroinflammation and autophagic flux 338442 2309 6774 4512 6010 5465 2308 3920 8408 7942 114548 PMC10779351__F2 NADPH Production Pathways in Cells 2821 2539 2597 4199 10873 3417 5226 4522 3418 10797 4335 PMC10779351__F4 Illustration of Insulin Signaling and Resistance Pathways 7186 5163 3667 2539 2475 PMC10779351__F5 Illustration of Ferroptosis in Pancreatic Beta Cells and Its Relation to NADPH 7018 7124 6510 2744 2937 2879 PMC10779434__F2 The actin cytoskeleton within the foot processes 7225 5879 387 23607 54434 998 8826 81 PMC10780299__F4 Activation of the NFKB/MAPK signaling pathway by saponins regulates the expression of a series of immune-related cytokines, NO, surface-stimulating factors, and mRNAs and/or proteins of the cell cycle 3550 4615 6722 1386 3558 PMC10784739__F7 TIFA regulating the inflammatory and osteoclast differentiation in the RAW264 4318 114548 4772 PMC10796096__F1 cGAS-STING signaling pathway in amyotrophic lateral sclerosis (ALS) 54209 115004 203228 7415 8878 6647 29110 3661 10133 3181 PMC10796102__F3 Possible mechanisms of co-occurring neuroinflammatory response and brain edema in patients with hepatic encephalopathy and potential therapeutic targets for hepatic encephalopathy 7124 7424 361 PMC10796102__F4 Binding of CCL19/CCL21 to CCR7 activated signaling pathways in tumor cells, including PI3/Akt, MAPK/ERK and Jak/STAT, which enhanced the expression of VEGF-C and thus promoted lymphangiogenesis 940 942 941 6363 6366 1236 7424 PMC10796102__F5 Communication between the gastrointestinal tract and cerebral lymphatic system is mediated directly and indirectly by immune, neural and endocrine pathways 1325 361 114548 54209 PMC10796104__F1 Mechanisms of Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) in chronic pain 857 3717 6774 9021 90865 6347 PMC10809359__F7 PPI network of the signalling molecules regulating macrophage activity and HIF-1 signalling pathways 57126 286 640 230 3684 4313 3945 383 6132 7076 5209 3566 11224 6206 3565 3162 6217 2242 6194 PMC10812436__F3 Main anti-inflammatory properties of HDLs 7124 7412 3383 6347 PMC10813560__F8 Heatmaps were generated to visualise the notable pathways identified as significant by DIANA-miRPath (v 23118 174 572 5914 PMC10814159__F3 MDM2 and CDK4 pathway regulation 4193 1029 1019 PMC10814280__F1 RABV-induced incomplete autophagy 835 9140 10410 64422 23192 10533 8408 PMC10814950__F8 Key signalling pathways targeted by a combination of PI3Ki (PIK-75) and CDKi (dinaciclib) 983 2475 1019 5925 1017 PMC10814963__F2 Common mechanisms of melanoma progression and treatment resistance 1956 4893 780904 673 PMC10815168__F1 Schematic diagram depicting the miRNA signaling pathways activated by aldosterone through the MR 1994 65125 3291 768219 816 6446 55000 857 50618 6453 4092 5728 7078 PMC10815231__F4 Graphical summary of the mechanisms of action of miRNAs and lncRNAs in DKD 1958 51024 494328 79068 80267 5865 9475 6774 50507 2475 49 79727 378938 PMC10815547__F8 Scheme of the ginsenoside biosynthetic pathway in ginseng according to Li et al 4598 9961 6750 8213 344022 2973 2160 2885 PMC10815595__F1 HBV-HCC pathways of top 10 downregulated miRNAs 7046 1026 4609 619501 1147 4790 596 2885 7419 6714 3845 5595 3725 7157 355 1017 5925 1869 PMC10815595__F2 HBV-HCC pathways of top 10 upregulated miRNA 6714 1642 836 PMC10815772__F1 FGF/FGFR and downstream signaling pathway 10818 2885 2549 2475 PMC10816189__F5 Cell cycle metabolic pathway, with Zhuansihao serving as the control and 071113 as the experimental group 4088 4087 9126 10735 10274 4089 4193 6502 324 9184 991 5111 993 1017 1022 990 8318 929 924 4999 5000 23595 23594 PMC10816189__F6 Plant hormone signal transduction pathway, with Zhuansihao serving as the control and 071113 as the experimental group 108348016 64641 1879 51411 8161 PMC10816282__F7 Proposed scheme for transcriptome stress response to APS 83939 2353 3725 4312 474168 PMC10816924__F7 KLF10 in cardiac fibrosis 7071 596 581 9232 3065 3578 PMC10819745__F3 Pattern diagram of immune cell response process triggered by PRR signal triggered by HSV-1 infection 7097 4615 3654 51135 7189 4118 7098 51284 51311 54106 57506 7187 29110 115004 3428 3661 64423 PMC10819970__F8 Engineering CXCL12 biomimetic decoy-integrated versatile immunosuppressive nanoparticle (VIN) for the management of overactivated brain immune microenvironment 9242 7852 6387 115004 383 PMC10820115__F3 Canonic polyamine biosynthetic pathway of mammals (hosts of trypanosomatids) 84890 25913 1984 PMC10820555__F3 Study on the Pharmacological Mechanism of Icariin for the Treatment of Alzheimer’s Disease Based on Network Pharmacology and Molecular Docking Techniques 7099 6774 638 8453 100996569 1610 2056 7037 5163 5211 2597 226 3939 PMC10821092__F1 Pharmacology of Veratrum californicum Alkaloids as Hedgehog Pathway Antagonists 8405 6608 374654 51684 4342 57758 156 2737 2736 50937 2619 91653 PMC10825793__F3 EBV-miRNAs modulating inflammatory signaling pathways 1147 7410 7097 3665 57506 7124 8717 2353 3725 3718 2534 PMC10831399__F3 NRP-1 gene expression generating axis of stem-cell properties 8829 79923 389421 PMC10831402__F2 Suggested PML/RARA-related signaling pathway that leads to cell proliferation and the evasion of apoptosis 999 1499 3728 5914 5371 1027 1017 PMC10835843__F8 Expression heat map of related genes and metabolites in phenylpropane biosynthesis, ascorbic acid, succinic acid and glutamic acid metabolic pathway 1312 3099 1431 4335 4967 2744 2937 6101 6102 PMC10836028__F9 Schematic figure showing that melatonin attenuates mechanical trauma-induced hepatic injury by inhibiting IP3R1-mediated MAMs formation via activating the melatonin receptor-ERK1/2-FoxO1 pathway 2308 7416 2922 PMC10836493__F3 Mechanism by which GPX3 is involved in maintaining the stemness of OCSCs in the TME 2878 6319 8205 7038 960 PMC10837142__F7 Peroxisome biogenesis pathway in T 5191 5805 5830 5189 5190 9409 8504 55670 5193 5828 5192 5194 5195 5824 5827 4358 11264 PMC10838060__F1 Molecular mechanism of the cGAS-STING pathway 29110 3428 6786 22954 81844 7187 7189 7099 54106 7010 PMC10838060__F10 CGAS-STING by metal ions 115004 114548 2237 6786 PMC10838060__F2 cGAS-STING pathway and the NFKB pathway 472 29110 7189 8408 22954 85363 PMC10838060__F8 cGAS-STING and cell senescence in diabetes 2177 115004 29110 4361 11277 140805 PMC10838672__F3 PI3K/AKT/mTOR signaling pathway and targeted inhibitors 2064 1956 5979 5163 5728 7249 7248 2932 572 6733 2308 595 PMC10843903__F6 Increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study 10682 1977 7249 613 6850 930 5728 5934 572 PMC10844198__F2 Putative NFKB signaling pathway data mined from Euprymna scolopes reference transcriptome and genome 4615 51135 7187 7186 9618 29110 7189 197358 84231 10454 257397 PMC10844364__F1 Main functions and metabolic origins of novel acylations 29766 64223 1017 84844 PMC10845554__F1 IL-17-producing Treg differentiation 920 3558 50943 64375 22807 1493 1235 29851 4094 6774 325 6097 6497 4088 4089 324 1655 196 7099 3685 1236 PMC10845928__F1 Immunologic properties of cancer stem cells (CSCs) 6890 6891 634 2475 6774 57761 6925 1499 27243 3099 6662 6352 6347 961 140885 1435 PMC10845928__F2 Ferroptosis in CSCs 26872 2512 23657 6520 3178 2879 7852 2920 PMC10845928__F3 Mechanisms underlying radio-resistance in CSCs 9156 5888 6774 472 545 894 993 1017 22863 PMC10845928__F4 Mechanisms underlying chemoresistance in lung CSCs 7474 9475 5058 4851 8788 3280 9429 100187761 4800 10622 217 5243 648 PMC10846380__F6 CK1A degradation by FPFT-2216 and subsequent p53 pathway activation and CBM complex/NFKB pathway inhibition 1642 8451 51185 10892 4193 84433 8915 PMC10846991__F3 Interleukin-6 (IL-6) signaling pathway 6774 25759 2475 PMC10848377__F2 Koetjapic acid molecular mechanism in curbing carcinogenesis 596 581 3717 4088 4087 4089 PMC10850140__F7 Exploring the mechanism of action of Sparganii Rhizoma-Curcumae Rhizoma for in treating castration-resistant prostate cancer: a network-based pharmacology and experimental validation study 367 6716 5728 1017 5328 5327 7018 572 5163 4193 2885 PMC10850268__F1 Signaling pathway of insulin action and the selective impairment of insulin receptor substrate (IRS)-protein kinase B (Akt) signaling pathway in insulin resistance 948 3667 8660 5170 2308 2475 PMC10851565__F3 Autophagy’s dual-edge effect on NF-KB and PI resistance 4615 3654 51135 23118 257397 1540 5966 8717 90268 7412 6850 472 8408 3383 5971 9140 PMC10853261__F8 Proposed model of GC-induced adiposity 687 64147 5743 383 6774 25942 7350 PMC10853543__F4 SOX TFs acts as the hub of signaling pathways in the tumorigenesis 3082 9112 4087 94234 9965 2264 1230 10818 2932 11063 6656 6657 6659 6662 6664 9580 6666 54345 2146 1825 7291 238 9982 2744 3728 2806 4162 5159 3678 3479 440 4316 2324 6354 1000 999 3570 2120 83595 10644 1660 124901024 114548 1869 90427 8650 8842 6426 PMC10853571__F2 The pharmacological mechanism of fluoxetine in astrocytes 1956 6714 1950 5728 PMC10854459__F8 Anticancer role of JAC in AGS cells 89780 1017 6774 1019 1021 572 999 1000 1499 PMC10854592__F2 STAT3 signaling pathway: STAT3 activation is initiated by upstream activity including ligand binding by (a) cytokines (IL-6 and non-IL-6 family members), (b) growth factors (EGF, FGF, etc 2268 1956 6774 6714 7291 595 387 PMC10854678__F9 Arf6 signaling pathway, the inhibitors used in this study, and a model of MuLV Gag release 2475 382 5337 5338 967 PMC10854713__F3 Phosphorylation regulates EMT and other functions of CRC cells 79144 5728 8877 3717 4088 324 10295 6714 64077 1499 165324 6774 2264 3679 6773 64083 1869 4306 23043 PMC10854713__F5 Glycosylation regulates the metastasis of CRC cells 51083 718 6480 3383 3732 2146 8473 10724 10402 100124700 2475 1499 2932 324 9945 2524 6935 PMC10854734__F5 SADS-CoV infection induces apoptosis and complete autophagy 8772 5354 2475 8408 79868 22863 841 637 842 2002 PMC10854812__F9 Downstream effectors of RTK-mediated pathways and their biological consequences 2886 4893 2885 5728 64798 673 6446 4193 2932 331 596 PMC10854888__F1 HSP in biochemical functions of cells 718 572 637 581 717 7099 9776 22863 PMC10854933__F2 An illustration of the theoretical modes of action of the MRGPRX2 signaling pathway inhibitors 117194 6714 4067 84876 80228 PMC10856016__F2 Phosphatidylinositol 3-kinase (PI3K) protein kinase B (AKT)/mammalian target of rapamycin (mTOR), PI3K/AKT/mTOR, and mitogen-activated protein kinase (MAPK) signaling pathway activation in gastric cancer (GC) 2263 1956 3845 5290 7157 2065 572 581 2308 2475 1977 2638 PMC10857159__F6 Expression of DEGs involved in the plant hormone signal transduction pathway of M 7018 51411 4881 PMC10857240__F1 Proteins and genes involved in chlorophyll synthesis pathway 7390 3145 7909 7389 1371 4256 5498 4553 5447 27159 PMC10859375__F5 Lipid laden macrophage accumulation in the p 5346 729359 4023 948 10577 2167 2180 84649 6319 PMC10860821__F3 OA is a condition that involves the breakdown of cartilage in the joints 114548 3553 11096 PMC10861537__F7 Summary: impact of chemotherapy on CAF-S1 and CD8 T cell density in HGSOC 2191 84168 10413 5551 3002 PMC10861954__F4 Apoptosis and Inflammatory Signal Pathways Associated with Unremitted ER Stress and UPR 468 83939 22926 7186 PMC10862883__F5 Acceleration within PREs widely affects the Notch signaling pathway 182 3714 28514 3955 4242 4851 4854 4855 1855 6868 1856 1857 8650 23385 1840 113878 51107 196403 83464 7088 1487 1488 7089 3516 3065 3066 79816 9612 6310 22938 11317 9794 1387 9541 2033 84441 8850 55534 3280 23462 23493 388585 171558 26508 PMC10865100__F1 Classical model of G1–S transition regulated by cyclins and cyclin-dependent kinases (CDK) 6774 1017 2475 1019 1021 7045 983 PMC10865172__F3 Roles and mechanisms of ESM1 in tumor angiogenesis 1950 11082 1956 54567 23118 6774 10454 257397 2475 7450 PMC10865529__F5 Phenolic metabolic pathways and associated network diagrams 1312 729230 1233 1234 1237 790 PMC10865661__F15 Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IKKB/NFKB p65 signaling pathway: insights from in silico and in vivo investigations 1610 4513 998 572 PMC10866157__F6 Schematic diagram depicting the mechanisms of 5-aza-dC treatment in inhibiting choroidal neovascularization in a laser-induced mouse model 4041 4040 324 8312 8313 147111 595 51176 PMC10866657__F2 BMP9-10/ENG/ALK1/SMAD4 signaling pathway maintains vascular quiescence by repressing angiogenic pathways 27302 5281 2022 7422 7423 5728 7046 4087 4088 4090 4086 6446 4089 1019 1021 PMC10867181__F3 Hypoxia regulates the metastatic cascade 6935 6929 4015 51129 7852 3091 5048 3611 1499 PMC10867724__F4 Demonstration of the TNF signaling pathway and the target to be tested 7124 8717 4703 1540 83737 8772 836 197259 7186 1434 8168 3725 64127 6401 PMC10869077__F9 TNF signaling pathway 7124 329 10454 2353 7186 8717 6364 6347 2920 6372 1435 1437 8737 1051 355 182 4790 468 9530 3569 3600 3976 4049 3551 4792 7185 602 7128 9021 1147 1540 840 8772 836 11035 83737 8837 331 3726 3725 4323 4318 4314 2277 64127 6401 3383 7412 5743 197259 192111 10059 5290 207 7187 153090 3659 3456 PMC10869406__F5 Relationship between major genes and the PI3K/AKT/mTOR signaling pathway 10016 311 5605 805 1514 816 1973 972 1508 2475 1509 3482 396 387 6242 9475 817 392 1977 PMC10870057__F2 Molecular regulatory mechanisms of dormant PGCCs 998 999 6790 995 9212 7025 4609 6657 5997 545 PMC10870057__F1 Molecular regulatory mechanism of dormant cancer cells 6352 324 10733 56898 998 655 2475 5997 5111 PMC10871146__F1 Hydrogen maintains an anaerobic environment in the intestine and reduces oxidative damage via selective antioxidant effects 4353 468 7494 83939 PMC10873402__F5 JAK-STAT signaling pathway 2057 1270 3952 5618 2690 1440 2688 5617 4352 1441 7066 2056 1442 3953 1271 3570 3569 3578 3600 3572 3575 1489 3574 59067 3977 3581 10254 8027 9180 3976 3558 3596 3559 5008 3565 85480 1438 3560 3716 6772 10379 51561 1437 3561 1439 3717 5777 6773 3567 3592 53342 3563 3566 3718 5771 6774 3562 3593 3589 3568 3597 7297 6775 6777 3590 3598 6776 6778 3601 149233 50615 3594 64109 3595 5781 6654 3265 3460 3459 2885 6655 50604 3458 3456 3446 282618 3440 3586 3441 282616 3448 3449 11009 3442 282617 3451 3439 338376 3444 3445 3467 56832 3452 53832 53833 58985 3454 3455 116379 5894 3587 5290 5295 207 2475 3588 5291 5296 208 9466 163702 5293 8503 10000 PMC10873884__F3 Different self-incompatibility systems 80055 5601 2241 6098 2739 5337 PMC10874461__F2 X-linked osteoporosis in males 7450 5358 4041 4040 324 1499 PMC10874461__F5 Pathological mechanisms of osteoporosis induced by diabetes, glucocorticoids, and psychological stress 9242 1499 2691 1392 4852 10874 50964 3485 2638 2695 5741 PMC10874556__F1 Mechanical cue-dependent scarring 90865 6761 6774 6239 6935 9839 3589 PMC10874582__F2 Immune-related signalling pathways in mosquitos 4615 27161 192669 23405 29102 PMC10875024__F8 Key signaling pathways regulating stem cell pluripotency 6774 3976 3977 4838 652 100653366 6657 79923 133418 6498 6929 324 5978 PMC10875036__F5 IAV NS1 and SARS-CoV-2 Nsp1 antagonism of innate immune responses 3454 3455 7297 3716 7098 51284 4615 7706 83939 6772 3661 6773 9636 57506 3665 10379 PMC10875085__F1 Mechanisms for S protein-induced lung injury 27035 7099 59272 6774 114548 3569 PMC10875085__F2 Mechanisms for E protein-induced lung injury 64398 7097 114548 4615 3569 PMC10875826__F1 (i) ERBB/HER family members and their cognate ligands (ii) Structural difference of various (I-VI) types of NRG1 3084 1839 23118 9542 10718 145957 1950 7249 6009 PMC10875894__F8 VNP-shCCDC25 blocking CCDC25-NET-DNA and remodeling immunity in B16F10-bearing mice and 4T1-bearing mice 10763 998 5879 29780 941 3611 55246 4284 PMC10876307__F5 Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells 2885 387 377677 771 56934 770 768 23632 PMC10878139__F4 Cross-talk between glucocorticoid receptor and Wnt signaling pathways 1499 8313 324 22943 6422 4920 5879 387 PMC10879038__F4 Programmed endothelial cell death pathways 11035 8737 2879 2475 PMC10879038__F3 GSK‐3B as a converging point in key signaling pathways regulating BBB integrity post‐stroke 4041 4040 219699 324 1499 7248 7249 PMC10879484__F8 Therapeutics identified as strongly inhibited upstream regulators in Ingenuity Pathway Analysis 5054 9971 6773 857 7157 1387 2353 3725 5469 10379 PMC10879685__F2 NSCLC: from tumorigenesis, immune checkpoint misuse to current and future targeted therapy 2246 2260 1950 1956 3466 6774 6772 3659 4609 920 324 941 942 940 3932 10125 5728 5335 2885 5163 7409 998 2475 2625 PMC10881233__F2 Action of cryoablation combined with immune checkpoint blockers 324 941 942 940 PMC10882078__F7 TNF signaling pathway in atherosclerosis-related and non-related to CKD 7124 843 8772 6670 83737 7186 8717 7187 PMC10882314__F2 Emerging role of SENP1 in tumorigenesis and cancer therapy 581 29089 23410 6774 4313 3091 4318 29843 2623 6935 3099 56339 4609 2260 PMC10884763__F3 Illustrative representation of molecular mechanisms of obesity-induced non-communicable diseases 5728 7248 7249 857 2885 PMC10884928__F3 Prevotella along with NR supplements improving the signaling pathway of BCAA metabolism in MASLDNAD precursor supplements can affect fatty acid oxidation and lipid synthesis as well as the TCA cycle and insulin sensitivity 10295 10135 208 23411 7352 7351 355 PMC10885697__F2 MAPKs signaling is obligatory for male reproductive function in a development-specific manner 367 1956 6714 PMC10885964__F2 Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China 4086 4089 148738 4756 3077 7036 7018 650 652 25805 3458 4091 4092 25942 9978 3065 3066 79875 6497 6500 7057 4087 1874 2331 2014 1616 387 3547 4088 10468 4838 5308 PMC10886007__F5 PI3K/Akt/mTOR signaling pathway 6009 5728 5163 7248 7249 581 2308 PMC10886137__F4 JNK and p38 MAPK signaling pathway of filefish upon Cd exposure 7124 3589 3558 8717 4615 7186 3727 2002 PMC10886137__F5 Glycolysis pathway of filefish upon Cd exposure 3099 7167 2597 2023 2026 2645 PMC10886137__F7 Citrate cycle (TCA cycle) pathway of filefish upon Cd exposure 6392 6390 6389 4191 5162 1737 PMC10886236__F4 Heatmap of the pathway of glycolysis, antioxidant enzymes, and ascorbate–glutathione cycle 2597 7360 7358 4666 6648 847 57716 PMC10886467__F1 Relevant signaling pathway potentially being involved in the pathogenesis of polycystic kidney disease (PKD) and/or chronic kidney disease (CKD) 5163 5728 253260 2475 PMC10886467__F2 An illustrative representation and overview of PINK1, Parkin, and related molecules in the regulatory pathway for mitophagy 9927 55669 7416 65018 55486 10133 29110 PMC10886574__F3 Sirtuins Affect Cancer Stem Cells via Epigenetic Regulation of Autophagy 23410 22933 114548 23409 7852 3717 9242 51547 1499 6657 79923 51548 80312 54790 PMC10886582__F4 Necroptosis signaling pathway 8737 8717 8772 7186 1540 10454 23118 11035 197259 PMC10886920__F1 Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma 558 2621 5894 6772 6774 2475 4318 PMC10887009__F4 MR suppresses gastric cancer development by inhibiting GSCSs 326624 9474 1956 PMC10887023__F2 Gene interaction network of dyslexia and stress-associated genes 23136 10457 2289 231 6285 6532 55257 4306 93621 6091 26047 6900 10142 94137 94104 80790 2908 51473 9856 5116 1831 9801 54682 222865 24144 8848 23181 5028 79932 57534 6936 81628 1588 161582 100287284 3275 9819 1363 PMC10887079__F1 Nrf2 signaling pathway 9978 8452 9817 PMC10887103__F5 Defective PI3K/Akt pathway in T2DM results in insulin resistance and the activation of the pro-inflammatory, pro-apoptotic inhibition of eNOS and glycogen production 2475 5350 6262 PMC10887252__F5 Molecular mechanisms for the involvement of the JNK pathway in insulin resistance 3667 8660 1734 3569 2002 1386 9611 5465 26291 PMC10888037__F8 Schematic diagram showing the potential pathways which were more active in non-mucilage BS 2821 2242 1431 6389 4967 4171 5982 4174 4175 5985 5983 1738 1743 PMC10888202__F6 Comparative analysis of DEGs at different growth stages 5236 2597 5230 PMC10888344__F9 Molecular mechanism that drives the positive impact of CSE in OVA-induced AR mouse model 90865 6761 7124 4155 999 PMC10888452__F1 The PI3K/AKT signaling pathway and its activation 7249 7248 5728 7189 5163 4193 572 PMC10888650__F4 ABCC8 Expression in Hypoxic and Inflammatory Conditions 7186 4615 6667 6833 PMC10888664__F2 Evolution of CRC 324 4893 3845 4089 1630 7157 1499 673 7048 PMC10889086__F1 Bruton’s Tyrosine Kinase Inhibitors: Recent Updates 613 921 933 930 4067 4615 695 29760 5336 942 969 941 84433 10892 8915 PMC10889199__F1 Endothelial cell senescence 2475 23411 1019 1021 PMC10889208__F1 Heterogeneity of the dermal fibroblast population 325 5156 26018 2252 8516 2200 PMC10889501__F4 Postulated relationship between IL-1B/IL-1RA axis and autophagy signaling pathway in invasive bladder cancer 5163 7248 2475 7249 PMC10889522__F6 Schematic illustration of YTHDF2 mediating the action of BDNF stimulating the proliferation of porcine follicle granulosa cells 627 51441 5111 1019 PMC10889780__F9 Putative roles of glutathione and AP-1 in the cooperation between VDDs and Nrf2 activators in inducing differentiation of AML cells 8452 9817 7421 6256 4094 PMC10891274__F1 YAP/TAZ activity is tightly regulated via Hippo signaling 4485 92597 55233 9113 26524 671 7004 7005 7003 8463 PMC10891858__F4 Major signaling pathways by ncRNA in NAFLD/NASH as discussed in the text (Created with BioRender 2475 283120 283131 100505854 PMC10892304__F6 Protein–protein interaction (PPI) network in biosynthesis of plant hormones and signal transduction pathways 4881 578 64641 PMC10892344__F6 Schematic diagram generated by IPA of the death receptor signaling pathway with which the DEPs with |FC| ≥ 1 22985 8772 4000 8815 PMC10892479__F2 Activation of the NF-kB signaling pathway induced by SARS-Co-V-2 and mediated by RIP/TRAF-dependent pathways or RIP-dependent/TRAF-independent IKKB activation 7124 4615 8717 51135 3654 7099 4050 23118 257397 10454 PMC10892479__F5 Illustrates a diagrammatic representation of the intracellular signaling pathways activated by SARS-CoV-2 infection 7098 51284 51311 4615 6348 PMC10892755__F1 Cholesterol and isoprenoid synthesis pathway illustrating how statins inhibit the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase 387 5879 998 PMC10893629__F4 Frequently altered signaling pathways in SCLC 92597 55233 26524 9113 4485 60485 596 6657 5727 2735 429 10683 5978 4609 100188776 2146 1387 2033 51684 6469 6608 10873 PMC10894496__F8 Optimized New Shengmai Powder modulation of cAMP/Rap1A signaling pathway attenuates myocardial fibrosis in heart failure 5906 6774 595 PMC10894836__F2 MiRNAs on gliogenesis 100187761 8091 4854 6662 896 PMC10894836__F4 MiRNAs in Müller cells on retinal regeneration 79727 1406 6657 999 3329 7168 27122 9314 3688 58190 PMC10896898__F3 Recreated RAS signaling pathway 7074 2885 6654 5923 5900 9610 11186 4485 6010 29110 998 PMC10897204__F6 Newly identified APA-linked cancer susceptibility genes are enriched in metabolic reprogramming and apoptosis-related pathways 578 9324 56006 7015 3845 5295 151050 5290 355 7157 83787 2593 4851 57326 4784 57580 207 51524 100128881 843 56942 22937 83734 5604 57332 10623 84916 2199 27352 55737 11200 55437 440248 92822 675 439921 672 23383 23567 5439 10156 9784 9874 2255 283635 653361 146923 252983 63910 124045 120534 583 654433 84844 7086 6687 2186 23312 6727 326625 6714 29082 84272 101060226 441168 6827 79415 51177 51312 92335 5894 10397 51255 8837 2677 440434 5728 PMC10897999__F1 Roles of circRNAs involving interaction with RBPs or other proteins in GC 10643 960 8140 8637 27161 3172 11184 4855 4851 6517 80736 7555 5093 2876 PMC10897999__F3 CircRNAs work as translational templates to contribute to the proliferation and progression of GC 324 2475 5594 142 9978 7001 6418 PMC10898159__F1 Gene and epigenetic regulations of KIT expression in GIST 3815 79068 9421 6452 23476 2294 3090 2115 332 4286 10664 PMC10898159__F3 Mechanism of action of existing drugs targeting KIT expression and mutations 6608 5727 8643 2247 2261 2735 3815 272 6667 867 1022 23476 PMC10902128__F4 TGFB signaling pathway 613 8772 8717 7186 4087 4088 4089 324 847 920 PMC10902464__F1 Galactose metabolism and CG pathophysiology 130589 367 2584 2592 2582 101448070 PMC10903154__F1 Hippo signaling pathway and its network 4771 60485 4485 55233 92597 26524 9113 374 860 4609 PMC10903154__F4 Hippo pathway dysregulation from pancreas precursor lesions to malignancy 133 6774 6662 54623 PMC10903931__F4 Apoptosis model induced by fatty acid metabolism 7038 5091 581 PMC10903931__F5 LXR-LPCAT3-ERS signaling pathway 10162 7186 7494 22926 7124 83939 468 PMC10905161__F2 Nrf2/Keap1 signaling pathway 9978 8452 9817 571 3162 1728 2730 2729 5471 10797 3417 5226 355 948 8685 8408 10241 PMC10906782__F8 Different biological activities of DCV-derived soluble CPE and sEV-CPE 1363 3354 596 PMC10907440__F2 Positive effects of SGK1 in embryogenesis 6446 10397 7422 655 PMC10907749__F4 T. gondii antigen alters the signaling pathway of the host cell 1234 3458 8835 7099 114548 6778 6774 383 PMC10908104__F2 ALS disease pathological signaling pathway 203228 6647 2521 PMC10910037__F2 Crosstalk between NFKB signaling and other signaling pathways 973 3575 4067 6850 7099 4615 324 1499 PMC10910747__F8 Working model: BMP9/BMP10/ALK1/SMAD4 Signaling drives the regulation of direct and indirect pathways in ECs 4090 4086 27302 1019 4089 2060 2078 4091 3397 6401 3037 5743 4397 PMC10910758__F4 NFKB signalling during chondrogenesis in endochondral ossification 9242 655 652 650 5879 340419 3479 6662 860 5163 PMC10910758__F7 Therapeutics of endochondral ossification and FOP targeting NFKB signalling 23411 5970 4093 4086 4090 3146 90 7099 9242 6662 3397 860 PMC10910842__F3 Roles of the kinesin-5, 6 family members in HCC 259266 1499 3832 56924 9493 2305 2736 10112 286826 PMC10910842__F5 Roles of the kinesin-12, 13, 14 family members in HCC 56992 26227 1499 6925 11004 7248 7249 51256 3833 7291 4313 6774 999 3801 3796 PMC10912430__F1 Signaling pathways that may be triggered by cellular oxidation or inflammation during intestinal I/R 7187 51548 5465 581 23410 10935 6648 1728 847 PMC10912430__F3 Signaling pathways that may be triggered by cellular apoptosis and necrosis during intestinal I/R 5310 23410 5603 7187 10935 5300 65018 8841 3383 581 355 PMC10912430__F5 Signaling pathways that may be triggered by cellular ferroptosis during intestinal I/R 4129 7442 2879 7015 23657 2182 PMC10912430__F6 Signaling pathways that may be triggered by cellular autophagy during intestinal I/R 23192 79671 10628 139341 8508 8408 PMC10912471__F2 Notch signaling pathway in tumor immune microenvironment 8205 920 341567 PMC10912719__F7 Regulation of DNPNB enzyme clustering and purinosome assembly-disassembly under the control of regulatory proteins and signaling pathways 10606 471 158 5163 PMC10915378__F6 Neurodevelopmental and thalamocortical processes involved in epistasis driving spike‐and‐wave discharge (SWD) phenotypes in mice 27229 51400 5870 220042 5058 1499 1854 PMC10915952__F2 Small molecule compounds inducing the osteogenic differentiation of mesenchymal stem cells 22943 4041 4040 4086 4090 324 1499 860 PMC10916191__F8 Working model of lipid synthesis induces by PPAR and cell cycle regulation in GCs after MLN4924 treatment 948 10682 55902 2194 581 5111 1019 596 595 1021 PMC10916417__F6 Relationship between PS, PC, and PE in the glycerophospholipid metabolic pathway 5091 162466 9791 5833 23761 81490 PMC10917537__F1 Fundamental ferroptosis-related intracellular pathways and mitochondrial regulation 2879 4015 2182 7419 7417 27165 2875 637 PMC10917541__F3 NMN-mediated longevity and the main reasons for decreasing NAD+ level with age 8658 952 23411 PMC10917925__F2 Pathways included in the model 3280 3091 8829 6714 5728 5163 11113 PMC10917983__F2 Biogenesis and mechanism of miRNAs 54487 29102 27161 54464 255967 9924 PMC10917983__F3 Acrylamide promoted cell apoptosis via the miR-27a-5p-Btf3-ATM-p53 signaling pathway, adapted from Zhang et al 689 472 142 581 4728 PMC10919309__F4 Elucidating the role of Rhodiola rosea L. in sepsis-induced acute lung injury via network pharmacology: emphasis on inflammatory response, oxidative stress, and the PI3K-AKT pathway 2475 6009 7249 1975 2885 613 6850 930 4609 5728 5934 572 6256 4193 PMC10919760__F3 Targeted and immunotherapeutic agents screened in GC PDX and PDO models 6608 1956 4041 4040 2263 374654 51684 2737 2735 2736 3082 324 4485 7248 7249 761 545 7465 PMC10920255__F1 Macrophages participate in mediating inflammatory pain in GA 100187761 7099 114548 PMC10920911__F4 Lipid metabolic reprogramming on CRC 4018 56895 3553 355 1374 114548 6774 PMC10921668__F8 The early ATL80-dependent response to WDS and its presumed function in retrograde signaling pathways 4602 9575 2077 23261 PMC10921743__F10 AMPK involvement in central sensitization of chronic migraine 3371 29128 383 PMC10922197__F9 Mechanism by which NBP inhibits osteoclastogenesis is demonstrated 7189 9817 847 2936 4772 1513 2353 54 PMC10926087__F1 Activated hedgehog gene pattern correlates with dismal clinical outcome and tumor microenvironment heterogeneity in hepatocellular carcinoma 6608 2737 50937 91653 1452 374654 51684 2736 2932 55733 23432 85455 57758 156 2121 132884 5727 PMC10926276__F5 Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRB/PI3K/AKT pathway 3034 4151 4350 81030 2634 1020 6613 9146 3684 7320 9475 2022 10628 2764 2173 5159 6622 6291 5594 5819 10457 5062 80168 6319 440 9818 6385 286205 7169 2959 9420 2054 790 122622 51202 6715 3284 8634 4553 PMC10926624__F2 Molecular mechanisms of Trp metabolism in gastric cancer 115004 3661 1303 2877 196 6774 PMC10926848__F4 BCR signaling pathway and BCR-associated CXCR4 signaling in CLL 613 930 5728 4067 6850 5163 5336 6387 7852 7248 7249 6009 PMC10929194__F1 Canonical pathways downstream of KRAS mutations 3845 5898 5899 78990 2475 6908 3725 PMC10929194__F3 Signaling pathways in the TME 2921 10628 558 2621 PMC10929203__F1 Exosomes in psoriasis pathogenesis 7124 3569 56300 PMC10930821__F1 Common intrinsic and extrinsic apoptotic signaling pathways induced by anticancer drugs 8772 8717 581 637 27429 331 PMC10930821__F3 Summary model for the c-Jun N-terminal kinase (JNK)/c-Jun/activator protein 1 (AP-1)-mediated signaling pathway in anticancer drug-induced cell death 581 355 22926 PMC10930821__F5 Molecular mechanisms of immunogenic cell death and tumor-specific immune activation via unfolded protein response (UPR) activation by anticancer drugs 468 331 5027 5029 3146 7099 2357 3458 PMC10930821__F6 Enhancement of drug sensitivity via molecular therapies targeting tumor growth and antitumor immunity 942 941 1019 1021 PMC10930964__F1 Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets 64798 64223 253260 PMC10931026__F1 The polyamine synthesis pathway 262 4953 196743 6723 6303 6611 54498 PMC10931359__F3 S1PR signaling pathways in liver regeneration and HCC progression 1901 9294 1903 6010 999 PMC10931375__F5 miRNAs targeting different components of the WNT signaling pathway to promote tumorigenicity 324 22943 1499 100302142 4306 PMC10931536__F4 Selected epigenetic changes and host-virus interactions perpetrated by EBV nuclear antigens and latent membrane proteins 613 7189 5970 467 973 974 6850 695 29760 5336 6774 PMC10931645__F2 Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets 324 942 941 940 7124 27040 PMC10931690__F9 Diagram depicting the mechanism of neuroprotective effect of siponimod/BAF312 50945 3627 7293 6364 8074 6374 PMC10931763__F8 “Component–gene–pathway” network 5925 1956 7421 5340 5743 1436 6774 1813 836 3676 2260 5290 4914 1812 5468 207 4312 3558 598 1508 1565 3725 3357 7422 10855 5465 7015 154 4322 3356 3480 7442 4318 4915 1901 5144 2908 PMC10931770__F2 Positive and negative regulation of osteoclast differentiation 7189 10454 23118 6387 6376 54209 10682 4772 780905 5079 122953 468 PMC10932453__F2 Non-coding RNAs in the host response to M 9655 23118 3845 5495 4214 5728 2309 3725 2353 PMC10932453__F3 Immune response of the tracheal mucosa to M 324 7099 6775 6357 3458 PMC10932966__F1 Two Sphks play different roles 8877 114548 6774 56848 PMC10933834__F9 Biosynthesis pathway and gene cluster of erythromycin 5095 53 55 PMC10934115__F1 Genome-wide DNA methylation profiling identifies hypermethylated genes that are linked to regulation of multiple oncogenic signaling pathways in response to resveratrol (RSV) in breast cancer cells 84441 54361 7475 51384 5578 5579 5308 3845 207 10000 5336 5727 139411 2475 6196 PMC10935043__F7 Diagram picturing two alternative pathways of sorting damaged mitochondrial components into mitochondrial-derived vesicles 51429 65018 5071 PMC10935119__F9 Enzastaurin, midostaurin, and lestaurtinib 5728 2322 2475 PMC10935305__F9 Graphical illustration of the interaction between the gut microbial SCFA-induced Nrf2 redox signaling pathway and LPS/ROS facilitated systemic inflammatory cytokines 1728 2941 847 4615 7097 7099 4513 114548 7189 PMC10935410__F4 Protein-to-protein subnetworks involved in prolactin, leptin, BDNF, and neurotrophin signaling pathways in CD4+ lymphocytes 572 5894 7532 7531 596 3265 5770 5295 2932 8660 2885 581 207 7157 5580 3667 4915 627 4790 6777 2534 5781 6464 2099 6714 595 2064 5970 5747 25 2475 4137 6774 1147 8648 7534 7409 6853 5777 PMC10937114__F3 Hypoxia affects adenosine signaling pathways in erythrocytes(A) AMPK-BPGM signaling pathway 84890 8877 136 669 272 PMC10937367__F3 Effect of uridine on disease through O-GlcNAcylation 4760 207 5163 2475 2308 2539 351 3398 PMC10937391__F9 Hypotheses on the mechanistical/functional involvement of each microRNA and its potential mRNA targets on OPC differentiation 2534 22800 3725 387 9844 5879 5728 4155 5058 6863 6009 11214 595 5354 10890 745 664 64506 1363 PMC10937431__F3 Signalling pathways and targets of botanical medicine flavonoids against CIRI-induced autophagy 2475 8408 9776 55626 22863 55054 9140 9474 64422 11337 PMC10937431__F4 Signalling pathways and targets of botanical medicine flavonoids against CIRI-induced PANoptosis and ferroptosis 7124 197259 8717 8737 7188 7186 23118 257397 9825 8772 841 2182 637 9817 58484 81030 79792 10162 11035 2937 1687 2879 PMC10937592__F5 Possible mechanisms of SCFAs-induced epigenetic modifications to improve NAFLD 1786 8932 2475 7528 494327 PMC10938139__F2 Research progress of periostin and osteoporosis 324 1499 51176 PMC10938947__F2 Introduction of pathways related to bone regeneration, like WNT signaling pathway 4041 4040 324 9242 PMC10938947__F3 Introduction of pathways related to bone regeneration, like Hedgehog signaling pathway, Notch signaling pathway and FGF signaling pathway 3549 2735 2736 6608 182 3714 28514 54567 10683 2885 10818 100188776 2549 9242 PMC10938947__F4 Introduction of pathways related to bone regeneration, like BMP/TGFBsignaling pathway 4091 4092 10454 4087 4088 4086 4090 4089 9242 PMC10940030__F4 Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases 2534 6850 9846 375 6010 2475 6497 PMC10940142__F1 Schematic overview describing the target pathway and overall metabolic strategies for heme production 4553 7909 1356 1362 56961 PMC10940682__F10 Glycosylphosphatidylinositol anchor proteins (GPI-APs) play a role in several cellular signal transduction pathways 135228 929 7099 4087 4088 6774 4615 7124 939 1956 2348 PMC10940682__F4 S-palmitoylation is involved in the regulation of multiple cellular signal transduction pathways 3265 1956 2885 355 115004 6097 6774 3717 3661 23513 4040 1499 324 7474 55750 5728 255738 PMC10940682__F6 N-myristoylation is involved in the regulation of multiple cellular signal transduction pathways 85409 324 4836 3932 4067 613 695 7099 7535 27040 5335 9148 4615 3661 2475 PMC10940682__F8 S-prenylation is involved in the regulation of multiple cellular signal transduction pathways 6009 2885 2475 64223 7074 9610 998 11074 57506 6010 PMC10941343__F9 Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach 59341 1267 10365 387 7124 126669 652 351 PMC10942021__F9 Crosstalk between mTOR and AMPK 3630 8717 51382 7248 7249 2309 6502 1017 387 PMC10942825__F6 Signaling pathways of DUSP22 in EndMT 56940 4088 4087 1003 PMC10943178__F10 The effects of EC‐EVs in sepsis‐related ALI/ARDS 7412 3676 941 942 PMC10943832__F5 AhR signaling pathway 3717 6714 196 7018 1642 10607 8450 9978 405 367 1499 57491 114548 3586 1316 PMC10943956__F2 SASP regulation of aging intervertebral disc cells converges on the p53/p21 and p16/Rb pathways 5728 7248 7249 29110 115004 472 3014 6741 PMC10944245__F10 Cytotoxic effect of flavonoids resulted from nuclear factor erythroid 2 (Nerf-2), Ak strain transforming (Akt), and nuclear factor kappa B (NFƙB) pathways 9817 5728 5163 4615 PMC10944245__F9 Cytotoxic effect of flavonoids related to MAPK and PI3KAkt pathways 673 1950 5163 5728 PMC10944252__F2 Enrichment analysis of KEGG signaling pathway, hub gene screening and PPI network analysis based on Genemania database 6229 6157 64960 5036 79590 6183 9790 6189 134430 55651 10436 6155 1938 PMC10944288__F1 chemokine signaling pathway (hsa04062) as outlined in the KEGG database 572 1794 8205 5624 PMC10945197__F1 Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis 378938 2526 6387 4088 2475 5728 4440 998 100423026 57659 387 PMC10945329__F13 MSC-EV effect on bone regeneration 3586 3589 3557 7124 114548 4811 3091 5741 9242 633 650 6320 89780 641373 378938 PMC10946270__F3 Classical and alternative pathways of NF-KB signalling are mediated by a variety of receptors and signalling molecules, including TLR, CD30L, CD40L, RANKL, etc 8915 4615 7189 3654 51135 10892 84433 5971 PMC10948231__F2 PPARG and the PTEN-PI3K/AKT Signaling Axis May Cofunction in Promoting Chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma 5468 10000 208 207 5728 5290 PMC10948527__F2 SHP2 signaling pathways: SHP2-dependent signaling in both developing and established cancer cells is illustrated, with arrows denoting positive regulators and T-bars indicating negative regulators 3667 9846 6714 2885 8844 2475 1499 595 PMC10948527__F4 Immune cell-specific roles of SHP2 151888 940 7535 5817 3702 10666 201633 961 2475 140885 4283 324 100133941 3394 3206 3458 1436 3586 1435 PMC10949532__F1 Non-canonical NFKB pathway and its regulation: The non-canonical signaling pathway may be initiated through the binding of a variety of exogenous ligands to their cognate receptors (top right) 10892 8915 958 939 4055 7187 7186 80829 6774 5971 56957 91662 29110 PMC10949534__F10 KEGG pathway analysis: (A) PI3K-AKT signaling pathway and (B) MAPK signaling pathway 7249 2022 2475 6850 930 951 5934 5728 572 4602 6722 4149 2316 7054 8717 351 355 1616 4208 23118 51701 PMC10949534__F11 Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression 5747 1956 2099 6774 367 6714 5594 5295 207 PMC10949727__F3 FOXO3a regulating EMT and drug resistance in breast cancer 4193 6502 51548 999 23476 1021 PMC10949864__F2 Cancer-associated alterations of Ca2+ fluxes at acidic tumor microenvironment and targets 8532 7223 7220 7224 1499 5894 387 6093 83939 6446 6774 5243 7442 283871 PMC10950852__F9 Paradigm illustrates the beneficial efficacy of ginseng extracts in modulating circadian rhythm and inflammation 9575 5111 2865 7099 8993 26291 64127 PMC10950892__F2 Shows the benefits of Warburg and molecular signaling 6009 7248 7249 5728 3099 2821 2539 25796 5226 3091 1977 5163 2746 2744 PMC10950925__F5 Ferroptosis Signaling Pathway 7018 6510 2744 55240 2937 2879 PMC10950953__F4 Immune cells interacted with jaw stem cells by signaling pathways 154075 4087 7124 6608 4088 1749 860 51684 324 1499 9242 9780 PMC10951222__F5 Tumor evolutionary analysis and clinical vignettes for patients who derived clinical benefit from palbociclib, everolimus, and exemestane triplet therapy 5290 2064 58508 2099 4763 207 7157 PMC10951504__F5 Underlying mechanism of obesity and hyperuricemia 7124 5443 338 9370 2597 6347 7157 1401 3569 3725 3630 5972 348 213 847 3952 1636 2875 5465 PMC10951504__F6 Associations between obesity and hyperuricemia combing mendelian randomization with network pharmacology 2475 8717 7124 7186 9021 5443 3952 6774 181 4852 PMC10952045__F4 Various molecular mechanism of the osteogenic and osteoclastogenic function through cellular uptake of GNPs and functionalized GNPs 594857 5879 5008 10682 860 650 4322 4772 100187907 126014 PMC10952836__F1 Signaling pathways involved in ferroptosis regulation 100 2182 10162 6520 2879 23657 780904 55240 8463 PMC10953212__F2 Glucose–insulin signaling pathway 2645 3667 8660 5167 2646 2308 2194 PMC10954797__F2 Graphical representation of stress signal-mediated dysregulation of p53 expression during progression from colitis to cancer 472 545 3081 PMC10954797__F4 ERCC4 may serve as an important regulatory factor for the upregulation of PD-L1 expression induced by DNA damage signals and DDR defects 472 545 2072 PMC10955039__F6 Hippo signalling pathway in ferroptosis 23657 2879 51129 2012 2182 50507 PMC10955158__F5 FLRT3 and TGF‐B/SMAD4 signalling: Impacts on apoptosis, autophagy and ion channels in supraventricular tachycardia 4838 238 23767 PMC10957538__F1 Impact of particulate air pollution on airway injury and epithelial plasticity; underlying mechanisms 727897 3553 3569 999 114548 PMC10957538__F2 Epithelial plasticity and impact of particulate matter (PM): Exposure to PM in short term, leads to inhibition of Notch1 by stimulating STAT3 and aryl hydrocarbon receptor (AhR) activation in basal epithelial cells 7356 6774 26278 196 23476 9839 6935 405 1000 999 PMC10957617__F3 Versatile Mechanisms of STING 115004 3661 9632 3099 PMC10957658__F1 AA metabolism 5228 4512 4049 1690 PMC10957658__F4 Membrane receptor mechanism of EET in RCC 1558 1573 1559 1839 1956 2308 595 581 596 PMC10958678__F6 Functional activities of mut‐p53 in cancers 4173 9134 5111 5606 1956 11073 5371 6657 8549 960 79923 8928 23657 6576 2114 7083 387 23405 4087 5728 1869 6925 1874 672 7150 7421 2308 6387 7832 23764 128209 468 836 PMC10960062__F5 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity 4280 7018 5468 7469 3169 2033 3172 1387 6256 7494 9572 1050 23476 1051 2908 5885 2874 3175 PMC10960062__F6 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity 4280 7018 5468 23476 3169 1387 83860 6256 229 2203 230 226 64902 5313 84706 3939 5230 2645 5162 2875 2874 5629 2033 7494 6095 10735 6908 7469 9612 9572 5211 189 5315 7167 PMC10960062__F7 Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity 4280 1050 3172 2033 23476 3169 1051 2908 5885 83860 5468 9572 7018 6389 8801 47 55526 50 1431 5106 3418 4190 4191 48 2551 3175 9575 1385 55193 1387 6095 2874 3297 6908 10499 3421 PMC10960729__F4 Activation and inhibition of the cGAS–STING signaling pathway in viral infection 5167 115004 29110 7124 3553 PMC10960765__F2 Ubiquitination enzymes in the Wnt/Beta-catenin signaling pathway of CRC 54894 84133 324 1499 27338 23327 64750 23650 5987 81847 9604 PMC10960969__F8 Metabolic pathway of methanotrophs 4967 2821 1743 3417 2012 1537 3416 2539 2597 25796 1431 1896 1636 PMC10961392__F2 Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases 4534 8897 9110 9107 9108 66036 6262 64419 8776 8898 115004 1392 55613 PMC10962118__F9 Mechanistic map of PELI1 ubiquitination of RPS3 activating the PI3K/AKT/GSK3B signaling pathway, promoting p53 degradation, and thus facilitating progression in PC 57162 6188 4193 PMC10962462__F2 Novel molecular targets in endometrial cancer (EC) 7018 1956 4485 60485 7248 2475 115004 7514 472 545 902 1022 983 7465 4661 PMC10963420__F1 Mechanism of astrocyte regulation of Lcn-2 3934 83939 4804 4792 50507 PMC10963452__F4 Schematic plots illustrate the signaling mechanism of other organokines in intervertebral disc cells 11167 23181 7942 9817 2693 55908 51129 2475 2932 4094 PMC10963904__F4 Metabolic map of the L‐methionine synthesis pathway of E 4118 11113 7067 PMC10964526__F8 Potential pathways of exercise training to improve pulmonary function 84101 50943 79054 6348 2475 PMC10965438__F6 Nanomaterials modulating TAM polarization for the treatment of HCC via the STAT signaling pathway 6774 9332 942 6772 941 6778 PMC10965438__F7 Nanomaterials modulating TAMs polarization for the treatment of HCC via the NFKB signaling pathway 7100 594857 51284 115004 942 941 6772 6778 208 207 PMC10967111__F8 RTEL1/JNK/ELK-1 signaling-induced tumorigenesis of glioma 2002 51750 7015 PMC10967338__F3 Therapeutic tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies in glioblastoma anti-EGFR mAbs bind the EGFR extracellular domain, preventing EGFR dimerization and subsequent activation 1956 685 7039 1950 2885 5728 5163 6774 7248 7249 6009 PMC10967338__F5 Allosteric inhibition of Aurora-A kinase by the vNAR-D01 intrabody 6790 6909 22974 5888 672 675 4193 581 1950 2932 1499 6774 1956 9076 PMC10967338__F7 TGFB canonical intracellular pathways and single-domain vNAR T1 coupled to TGFB1 4088 4087 4089 8163 PMC10967382__F5 Altered sphingolipid metabolism and signaling in monocytes and neutrophils during pneumonia 124976 19 7097 7096 7099 5091 7189 4615 114548 259230 7357 6609 166929 8879 8877 596 208 207 10000 5894 125981 340485 55331 9517 10558 55304 PMC10967848__F1 Representation of metabolic pathways of lipoprotein 335 3931 19 4547 3949 4023 345 344 5360 PMC10968029__F1 Illustration of GRB2 in humans and other organisms, highlighting its role in signal transduction and depicting the subcellular localization of GRB2 2885 867 2549 5888 5728 5930 4361 PMC10968029__F4 Configuration of GRB2 in Protein Interaction and Signal Transduction 1956 867 78994 2549 3667 6714 9846 2475 PMC10968131__F5 EFNA4, FGFR4, SLC3A2, and HNF1A are involved in signaling pathways that may promote carcinogenesis 2264 2885 3265 5293 3266 5894 673 369 1499 6520 4193 2475 324 6927 PMC10968226__F2 TRPV4 channels in osteoarthritis 59341 7124 6662 176 PMC10968558__F2 Mitochondrial dysfunction in the pathogenesis of SCA3 4287 596 7416 581 54205 PMC10968558__F6 Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review 847 3162 6648 6647 1728 4780 2729 2950 4287 10891 54205 6649 2941 598 581 6857 7157 3708 5332 3312 3297 PMC10968822__F3 Upregulation and downregulation of PD-L1 by YY1 through various factors 7528 5728 3716 6774 2475 PMC10968836__F3 TRAIL canonical signalling pro-apoptotic pathway 8772 637 331 8737 PMC10968836__F4 DR5 non-apoptotic signalling pathways 8772 8737 11035 197259 7186 8877 1386 6347 7852 PMC10968836__F5 TRAIL-induced non-canonical pro-tumoral signalling via DR5 secondary complex formation 1370 6010 6714 5879 8772 8717 7186 85451 6093 5728 1956 1386 6774 7042 2475 6347 PMC10969083__F4 Regulated genes in the Adrenergic signaling in cardiomyocyte KEGG-constructed pathway 468 490 6330 491 6543 11149 6547 64091 154 2778 816 815 23533 208 10000 146850 5566 10411 5567 11069 596 4625 4624 4602 805 808 810 6262 488 489 5350 9252 5330 5332 2776 183 7137 7139 7171 9254 784 55799 783 785 4633 5520 5515 5516 55844 55012 5523 5521 5526 5525 5527 5528 PMC10969083__F6 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways 5601 6416 2353 7124 7189 4615 3725 3569 51135 1147 3551 8517 5970 5515 3459 3460 5516 4843 5520 5521 55844 718 2770 7045 811 1636 2776 624 2773 2771 5332 2769 7042 7043 5331 2778 5290 208 10000 7046 7048 4087 8837 355 8772 841 3458 916 919 915 PMC10969083__F7 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways 1376 5166 5164 5165 10105 7417 4712 4720 4697 4722 4713 126328 4714 4698 54539 4724 4708 4725 4715 4700 4701 51079 4726 4709 4717 4702 374291 4695 4710 4718 4728 4719 4711 4696 4704 6389 6390 6392 1349 1340 1329 125965 1350 1339 4509 515 5162 51660 25874 PMC10969160__F1 Summary of potential therapeutic targets 4041 4040 1499 100302142 407047 664613 324 1950 6608 2475 648 6657 79923 960 4316 3202 64754 51684 PMC10970066__F1 Major components and auxiliary factors of the Notch signaling pathway (modified from ) 5927 1950 55294 2033 4609 896 PMC10970097__F1 The PI3K/Akt/mTOR signaling pathway 5728 5163 3845 4193 7248 572 6009 PMC10970167__F1 The protein interactome of PDE4A, B, C and D with their interconnecting protein neighbors 10399 2885 2534 474 6714 8161 6453 22890 409 10133 7185 25 5111 408 4193 4067 51588 3920 9472 2932 9049 839 2353 3725 4223 27185 4222 5080 4513 2928 PMC10970410__F8 Transcriptional Regulatory Networks (TRNs) based on DE pcRNAs common to KLF4KD and MXD4KD cells, in association with lncRNAs 102724105 163778 574414 284756 3936 100652988 10666 9955 101927630 109729169 196883 8605 5507 168667 58494 22854 84913 728264 627 5332 337876 6404 643401 3672 2977 79633 5587 100628315 81029 7168 387644 22808 6095 2318 633 1837 4325 5999 64131 6482 2252 2335 222663 1000 595 118597829 83660 100861555 8997 84848 140766 3569 9435 106660612 7431 23286 7042 2246 5308 3423 1906 1490 773 8325 5806 5021 100507516 100132111 101926996 6334 2668 8013 3037 6876 80830 678655 6641 25805 3725 3663 2634 115361 100131551 7096 6376 3400 100507291 100287896 57834 1033 80321 9133 207107 147841 4751 105369807 645 995 2941 4257 64946 54930 9232 119391 85236 5525 6119 55449 1373 230 768 PMC10970480__F2 Lipid metabolism-related proteins and pathways involving mitochondria-associated membranes 84649 6319 7417 706 7038 5662 1583 1727 PMC10970480__F3 Potential mechanisms by which exercise intervenes in insulin resistance through mitochondria-associated membranes 90550 7038 9927 139341 51024 PMC10971231__F1 Interplay of signaling pathways: cellular dynamics within the pancreatic ductal adenocarcinoma microenvironment 3569 90865 6347 4803 4318 4313 PMC10971254__F8 Binding of IL-25 to its receptor induces the transcription of IL-25 responsive genes via the TRAF6/NFKB-dependent signaling cascade and TRAF4/MAPK/AP-1-dependent signaling pathway 64806 55540 9618 7189 PMC10971967__F6 Proteomics analysis of gastrocnemius and soleus muscle in the ET group 5594 1737 3099 5160 5162 22933 5164 5230 5096 5095 4706 51074 30846 844 10383 203068 389125 1284 1277 2022 4191 4716 549 3910 PMC10973144__F2 Protein glycosylation is closely interconnected with glycolysis and other metabolic pathways 2821 5238 8473 10724 412 PMC10973673__F1 Crosstalk between non-coding RNAs and cell-cycle events: A new frontier in cancer therapy 1019 1021 1875 1874 999 472 2931 1017 6742 983 324 23411 545 7465 PMC10974036__F12 Recent Advances in the Nutritional Value, Chemical Compositions, Pharmacological Activity, and Application Value of Orychophragmus violaceus: A Comprehensive Review 9817 4094 3727 468 PMC10975175__F2 Heat stress triggers nitric oxide (NO) production and increases calcium levels 4881 338386 84273 117159 1431 PMC10975212__F5 Non-SMAD, non-canonical TGFB pathways 7189 4091 64750 9618 4092 387 2475 998 5879 7018 5062 PMC10975298__F1 Mechanisms of drug resistance in cancer cells 283871 581 5728 PMC10975298__F4 Signaling pathways against resistant cancer 1956 355 2695 5728 2475 4318 4313 1017 6608 572 51684 2735 374654 581 4851 PMC10975450__F2 Signaling pathway molecular mechanisms: Several signaling pathways play a major role in tissue development and thus in PSC differentiation, specifically into cardiac tissue 4041 4040 1499 324 4089 4838 4092 4087 4088 4086 4090 3667 8660 2475 3481 2308 2152 2309 6464 3549 6469 50846 6608 5727 8643 60485 26524 9113 2735 2737 2736 PMC10975841__F4 Dietary Factors on DNA Methylation Levels of TNF-Alpha Gene and Proteome Profiles in Obese Men 1977 6009 7249 5879 613 930 951 5934 5728 572 150365 4193 PMC10975890__F1 MAPK signaling pathway (KEGG: 04010) enriched in bovine fibroblasts infected with B 4351 2885 6722 4763 2316 3727 7124 8717 7186 1616 929 23118 7189 4149 4208 51701 1950 PMC10976388__S1 Depiction of Wnt Signaling Dysregulation in TNBC Cells When Compared to Healthy, Noncancerous Cells 4041 4040 324 1499 8324 607 PMC10976794__F2 Schematic overview of the Hippo signaling pathway 4485 6788 26524 9113 10413 8463 7003 92597 55233 60485 7004 7005 2810 7529 7531 7534 23237 PMC10976794__F3 Schematic overview of LMNA mutant pathways and MAPK3/1 (ERK1/2) initiated changes in cardiac remodeling 10413 25937 28514 4000 5595 5594 29109 6469 1846 2475 207 3725 PMC10976824__F2 Infection of endothelial cells by pathogenic microorganisms triggers the activation of the NFKB pathway, resulting in increased levels of HIF-1A 10333 7097 7096 7099 4118 4615 6714 6850 8737 7124 8717 7186 51135 57506 7189 64170 10892 8915 PMC10977553__F6 Mechanism through which agarwood against RAS 7124 329 2353 1051 6364 6352 6347 2919 6372 1435 1437 8809 355 182 7186 5609 8717 8737 5970 5606 468 9530 3551 1147 4792 1540 83737 8837 840 8772 841 836 11035 331 197259 5290 207 7185 7187 3553 3569 3976 602 7128 9021 3726 3725 4323 4318 4314 1906 2277 64127 6401 3383 7412 5743 153090 3659 3456 PMC10977574__F8 Compound-key target-core pathway 3932 4313 3002 5747 2324 10000 7442 5972 5241 695 4804 706 4638 1075 1129 5979 3683 4137 5467 2261 238 94005 43 1512 6622 2268 7124 5156 5465 5328 7422 673 1803 886 3718 3717 5021 1909 1020 203447 5045 472 7852 1509 331 PMC10977574__F9 Core-compound-core key target-core pathway 4314 5743 5781 4318 4792 238 2475 3791 7124 5468 3569 3717 3716 4312 2147 7015 1017 7157 1508 1956 3065 952 3932 596 5747 6714 331 3156 5290 367 2099 4193 5595 5295 4313 5294 2915 PMC10978726__F3 SKP2-p27 axis 6502 1017 6500 8454 PMC10978726__F4 Involvement of SKP2 in hematological malignanices 6502 1017 4609 2885 613 9846 PMC10978763__F3 Polyphenols and immunomodulation: a mitochondria-centered multi-modal approach 613 196 114548 6774 4513 3383 2475 355 PMC10979123__F7 Schematic diagram illustrates the multifaceted role of the redox-sensitive GSK3B in podocyte injury upon type 2 diabetic insult and the protective effect of targeting GSK3B 3667 3569 7124 1728 3486 PMC10979751__F3 Macrophages in osteosarcoma cell proliferation and metastasis 3717 6774 1950 7039 383 8205 PMC10981134__F1 Main alterations in TCR signaling pathway and accessory molecules associated with autoimmunity/immunodeficiency 940 941 942 920 3702 27040 50943 6777 3932 2885 PMC10981339__F3 Anti-inflammatory effects of SIRT in IVDD 7097 5970 23411 6839 51548 7099 PMC10981749__F8 Model for the induction of proinflammatory SASP by typhoid toxin 3454 3455 115004 29110 83939 3606 467 PMC10981756__F7 Mechanism of the antineoplastic role of PQR309 and gemcitabine in nasopharyngeal carcinoma 6774 999 1499 1000 PMC10982327__F2 Molecular pathways involved in animal glaucoma models at the level of retinal ganglion cell 4087 4088 4089 6714 355 PMC10982379__F1 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer 7018 55240 6510 2744 2937 2182 10162 2879 246 PMC10982379__F2 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer 581 596 5728 2475 PMC10982379__F3 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer 55107 5728 23657 2879 PMC10982379__F4 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer 23657 215 10057 7203 6774 384 1152 7076 2879 4257 PMC10982379__F5 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer 7018 23410 2182 55240 10162 PMC10982379__F6 Ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer 64781 10057 2879 2495 7416 23657 3458 5223 3934 PMC10982391__F1 Direct immunomodulatory function of TDEs on CD8+ T cells 100126341 355 8473 383 3135 648 4088 3383 PMC10982391__F2 TDEs indirectly regulate CD8+ T cells via the TME cells 383 3965 920 5281 4318 PMC10982457__F1 Viral RNA‐driven peripheral serotonin reduction impairs neurocognition by directly dampening vagal signaling 7098 3466 59272 PMC10982647__F8 Metabolic rewiring mechanisms in drug-resistant breast cancer cells 5209 26227 2194 3276 PMC10982685__F1 Integration of Psat1 into glycolysis and the serine biosynthetic pathway and its contribution to additional signaling mechanisms 29968 26227 4280 468 5723 PMC10985004__F5 Construction of signaling pathway between DEPs 23011 339829 221421 440 3315 1390 123872 207 7802 23499 80150 1537 36 1385 7416 646480 79054 6648 2475 4000 239 4184 3146 2879 6772 5468 7040 3303 39 3336 PMC10985190__F4 Communication between tumor cells and nerves facilitates tumor perineural invasion 1499 7852 1524 999 9353 6376 6387 23129 223117 64221 PMC10986035__F5 Pattern diagram for the role of NCAPD3 in NSCLC cell proliferation and apoptosis 3479 23310 581 1019 PMC10986082__F2 Multiple mechanisms of environmental stress regulating CSC transcription A The immune cells in TME activate the STAT, Wnt, AKT and Notch pathway of CSC by mainly releasing cytokines (IL-6) and inducing contact 960 10631 7018 1499 2475 8205 PMC10987301__F3 visually outlines the RAS/microRNAs (miRNAs) pathway in cancer metastasis, emphasizing the pivotal role of the Ras signaling pathway, particularly in tumor initiation and metastasis 5900 2885 5163 11186 PMC10987302__F1 Crosstalk between lncRNAs and Wnt/Beta-catenin signaling pathways in lung cancers: From cancer progression to therapeutic response 57291 3146 8313 7482 1499 1832 554203 6659 100506696 654434 PMC10987323__F10 MtETC in M2 macrophage polarization 3566 6778 948 5207 2147 2475 2744 PMC10987323__F9 MtETC in M1 macrophage polarization 5163 47 23152 5979 PMC10987652__F7 GSK3B inhibition inhibits microtubule dynamics 4131 150465 22846 374969 79805 PMC10987721__F2 Akkermansia muciniphila: a potential candidate for ameliorating metabolic diseases 7097 3384 2865 2867 7099 2328 7038 PMC10987773__F3 Hepatic glucose metabolic pathway during pregnancy 6514 3643 3667 208 51129 6517 PMC10987773__F5 Hepatic protein and amino acid metabolic pathway during pregnancy 4780 207 6198 2678 PMC10989355__F1 Pivotal signaling cascades in peripheral nerve regeneration (PNR) 4803 2668 387 627 10818 2885 2549 2932 2475 PMC10989355__F4 Molecular signaling pathways affected by electrical stimulation (ES) of peripheral nerves 627 2668 4803 PMC10989365__F6 CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway 800 5163 5728 PMC10990278__F1 The Wnt signaling pathway 4041 4040 64840 1499 324 8312 84133 54894 PMC10990754__F1 Various intracellular signaling molecules and pathways involved in HSCR 5979 2668 389400 4902 9048 5623 4908 6663 8929 9839 6469 3549 10887 128674 60675 3084 26128 223117 10512 PMC10990754__F3 NcRNAs related to cell apoptosis, proliferation, migration, and differentiation in HSCR 5728 5979 5880 1786 64096 1641 23236 57522 1871 100302212 693222 55384 84740 PMC10990851__F9 Integrated transcriptomic and metabolomic analysis reveals the regulation mechanism of early bolting and flowering in two cultivars of Angelica sinensis 64326 1999 574414 80758 PMC10991391__F2 Integrin receptors influence cellular metabolism through ECM sensing 6010 23175 2475 6737 PMC10992626__F2 Simplified illustration showing key pathways involved in disc degeneration 7124 4035 6385 11096 9507 3717 6774 176 PMC10993167__F6 FTO, ALKBH5 and pseudouridine synthase partial inhibitors and their inhibitory pathways are introduced 10642 79068 8651 51676 4609 5914 1050 54890 4255 PMC10993167__F5 Molecular mechanism of action of the FTO inhibitor 18097 8651 10642 1647 83734 57103 5371 7249 27165 7832 1643 581 1969 1200 2876 4255 1282 2309 27244 83667 PMC10993426__F1 Metabolites, metabolic pathways and related metabolic genes that play the roles in apoptosis 57103 10135 2475 47 2118 581 6319 317 8772 8717 PMC10993426__F2 Metabolites, metabolic pathways and related metabolic genes that take part in necrosis and necroptosis 468 51228 81030 11171 197259 PMC10993426__F3 Metabolites, metabolic pathways and related metabolic genes that play the roles in ferroptosis 8314 55611 23657 2936 2879 7018 PMC10993426__F4 Metabolites, metabolic pathways and related metabolic genes that play the roles in pyroptosis 3949 3606 114548 2167 2879 79792 PMC10993482__F5 Gal-1 pathways promoting EMT in cancer 4089 1901 7099 5163 4087 2735 4088 1499 2475 PMC10993482__F6 Gal-3, Gal-4 and Gal-8 pathways to EMT in cancer 1956 3480 5163 1499 860 PMC10994423__F5 Advances in the application of traditional Chinese medicine during the COVID-19 recovery period: A review 8737 7186 2885 23118 257397 2004 6772 2002 PMC10995332__F2 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma 7471 100126296 8324 89780 5879 1499 324 100302142 85407 51701 4609 51176 960 PMC10995332__F3 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma 3091 3611 5728 574449 6387 5163 2475 1000 999 PMC10995332__F4 MiRNAs affect the occurrence and development of EMT in liver cancer cells by activating the TGFB signaling pathway and cross-talking multiple signaling pathways including PI3 K and MAPK 100302284 693122 4093 4086 4090 693215 1789 4091 4092 4087 4088 4089 4313 4318 6667 2191 7431 1000 PMC10995332__F5 Underlying mechanism and targeted therapy strategy of miRNAs cross-regulating EMT process through multiple signaling pathways in hepatocellular carcinoma 442911 64754 10171 2549 8660 2627 7018 1499 6935 9839 1000 7431 999 PMC10995750__F3 Genes enriched in plasma membrane estrogen receptor signalling pathway 4088 2353 3725 861 573 2885 5925 896 7421 8295 7157 5515 6772 5451 2268 9611 23054 1457 10499 8648 6597 PMC10995981__F2 CircRNAs play a pivotal role in the advancement of esophageal cancer by modulating the Wnt pathway through diverse mechanisms 140809 83737 6659 1499 7976 PMC10995981__F3 circRNAs play a pivotal role in the initiation and progression of liver cancer by regulating the Wnt pathway through diverse mechanisms 5230 1871 1876 324 1499 219790 7545 27122 693211 PMC10996061__F2 Impact of amotosalen/UVA treatment on phosphoproteome signaling and platelet pathways 4217 5606 9261 3315 5062 6714 PMC10996135__F6 Distribution of common targets in the two most associated pathways 1977 6009 1975 7249 613 6850 930 951 5934 5728 572 4602 4193 4351 2885 6722 4149 7124 2002 8717 2645 355 1616 929 51295 51701 PMC10996278__F5 Major TCR signalling pathways 8651 9616 8065 919 868 921 84174 2534 7535 53347 399 3932 5777 3702 7409 27040 5335 998 2885 8525 1848 1606 8915 10892 5970 3725 2353 PMC10996278__F6 Critical genes and signalling pathways engage in T cell anti-tumour responses 8651 9021 8065 50943 2625 940 4055 84433 8915 10892 5970 3662 639 10538 9760 PMC10999050__F3 Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis 7124 842 581 4609 3553 836 841 5970 5743 5578 356 801 6774 5566 1026 595 2308 PMC10999658__F7 Molecular mechanism underlying CE accumulation in ccRCC and suppression of cancer progression upon CE depletion 7428 2475 6646 857 PMC11000312__F1 Mechanisms underlying SALL4 regulation and function in esophageal cancer 3608 4211 57167 6657 4851 4854 4853 28514 9794 29959 89780 1499 PMC11000535__F3 STAT3, EMT-TFs, miRNAs and lncRNAs form complex network to regulate EMT 283131 6774 7291 6935 PMC11001198__F6 Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue 1950 3569 6774 84699 4089 2056 57817 3077 151176 7037 1356 7018 3263 3240 9332 30061 3162 55652 57192 2242 51647 64210 PMC11002130__F4 tsRNAs as inhibitors of MAPK pathway activation via targeting MAPK-related proteins 627 776 6010 998 595 4553 6722 PMC11002443__F6 Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells 4157 4286 4482 PMC11002909__F2 Antiviral role of ubiquitination in enterovirus infection 81786 57506 10475 3661 6737 7706 91947 201292 PMC11003275__F1 Schematic chart for molecular mechanisms of metabolic dysregulation in DCM 948 355 1376 PMC11003748__F2 Clastokines produced by osteoclasts and osteoclast precursors and interaction with their receptors on cells from the osteoblast lineage 4772 1513 8877 1948 124976 2050 6010 6774 115908 89780 5879 3976 6586 6091 6092 4920 4041 3977 1000 860 1499 632 121340 1277 PMC11011430__F5 Signaling pathways upregulated in higher Gleason grade groups 546 9126 25836 5885 10735 10274 23383 23063 4089 4193 6502 9319 4118 9184 5111 993 1017 90381 27085 8318 1869 8317 10926 10763 5901 23636 8021 348995 79023 55746 6396 79902 4116 9775 10921 10284 51808 51068 23511 23165 53371 9631 55706 9883 59343 10762 57187 80145 79228 PMC11012558__F6 RTK pathways 1956 5156 3480 5163 6774 595 PMC11013310__F6 Our results are summarized in this diagram 3479 3082 1499 5111 PMC11015457__F9 Compound-target-pathway network 2247 7015 3815 5465 5290 2248 3791 7067 6774 5604 1956 5468 142 2885 3725 7068 6714 1432 5578 2475 3320 23411 7124 2099 367 4318 3558 836 5743 983 7054 7422 100187907 596 4193 5894 3480 4194 5788 PMC11015656__F2 20S proteasome inhibitors and their targets 7124 1019 1017 1874 891 PMC11016731__F2 Mechanism of tumor cell genesis induced by hypoxia inducible factor (HIF) 7428 2056 2475 PMC11019658__F1 Mechanistically, DHM inhibits tumour cell proliferation 993 7852 6774 6935 3146 PMC11019658__F3 Mechanisms by which DHM inhibits tumour cell invasion and metastasis 6667 6935 5728 999 1000 PMC11020452__F4 Regulatory mechanism of tsRNAs in cancers 3714 5728 221937 776 5163 324 1499 7248 7249 4193 1915 7018 PMC11020458__F4 Direct osteogenic effects and mechanisms of RE NMs 6905 4086 4090 324 2932 1499 9679 7008 PMC11021402__F5 Fe and S binding by ISCU2 at consecutive stages of de novo [2Fe-2S] cluster biosynthesis 9054 2395 112812 PMC11021430__F5 Representative scheme illustrating regulatory mechanisms of PTEN in BMSCs 3479 5728 10683 28514 54567 8788 65989 4193 2475 324 2932 545 472 23462 4094 PMC11021430__F6 Representative scheme illustrating regulatory mechanisms of PTEN in RPCs 2247 3479 3667 5728 51684 6608 6295 5727 6469 1499 7248 7249 2475 6009 3280 388585 4087 5080 9314 1958 PMC11021430__F7 Representative scheme illustrating regulatory mechanisms of PTEN in HSCFs, SCs, ISCs and SSCs 650 5728 9474 9140 10533 83734 64422 1956 2308 9794 9365 5979 6714 3815 PMC11021710__F3 Cell cycle signaling pathway (A) and cellular senescence (B) 546 1663 114799 9126 8243 25836 5347 5885 23383 10274 23063 983 151648 5515 9212 7040 5933 1029 9700 1874 4087 2932 7027 4089 5591 472 10403 7272 4193 6500 9232 6502 4609 9319 5925 7157 7709 57082 4085 1111 701 996 1647 2810 699 9184 991 7529 5111 993 595 1021 898 1017 890 902 1022 891 90381 25 27085 7465 8318 990 81620 1869 4171 4998 8317 10926 51343 2308 6009 2309 8945 2475 3265 545 4605 2626 5481 PMC11022384__F5 Therapeutic strategies targeting metabolism between GAMs and Gliomas 383 6713 4929 23475 9619 19 1717 335 PMC11022604__F1 Wnt/Beta-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target 4041 4040 1499 2932 324 PMC11023972__F1 DNA-damage response pathways 3014 5888 5884 84126 1642 1643 7508 545 472 641 5965 7486 5426 10721 7515 80198 7507 9156 4255 PMC11023972__F2 DDR components regulate IFNs signaling pathways 545 472 672 675 23476 641 10721 115004 2177 11277 5888 29110 3661 3428 80198 PMC11023972__F3 DDR components regulate cytosolic RNA sensors-dependent IFNs and NFKB signaling pathways 57506 7187 472 29110 3661 3665 PMC11024251__F2 Signaling pathway of EGF 1950 1956 2885 2549 867 PMC11024688__F4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of the PI3K-AKT (A, B) and mitogen-activated protein kinase (MAPK) (C, D) signaling pathway was mapped by fold changes 6009 3667 613 6850 5728 5934 572 6256 150365 1950 2316 3727 2002 8717 7186 1616 4149 4208 7124 PMC11025274__F2 Mechanisms by which the gut microbiota promotes CRC metastasis by targeting seeds 7099 64127 10392 1956 634 121278 8312 6347 1499 999 1000 6935 PMC11027554__F2 "hit and run" mechanism posits a potential role for H 6714 999 1499 6868 672 PMC11029991__F7 Bioinformatics-based discovery of biomarkers and immunoinflammatory targets in children with cerebral palsy: An observational study 8027 3558 3716 3717 3569 7297 3718 10379 2475 2670 6502 220441 6520 201163 2887 1977 4041 4040 2932 64798 6009 5728 2885 6010 64223 253260 PMC11032202__F6 Intratumoural heterogeneity informs intertumoural heterogeneity 3091 7428 54413 PMC11032739__F7 Musashi2 affecting radiosensitivity of lung cancer by modulating DNA damage repair 3014 84991 545 PMC11033278__F8 PPI interaction network 5091 10312 9194 9997 291 51763 29957 10102 4709 27089 4722 2313 2624 5277 80207 81855 4833 874 161882 4710 55856 10159 6341 100996939 4697 4696 3783 4731 4716 84419 29796 10588 55967 PMC11033433__F7 Non-coding RNAs involved in the regulation of radiation tolerance in cervical cancer (A) the relationship between lncRNAs and radiotherapy resistance in cervical cancer 60674 641638 100506305 1021 7528 5728 6241 6815 595 3217 2919 1994 2475 1399 1026 5888 51441 56339 PMC11033503__F1 C/EBPB regulates signaling pathways associated with brain inflammation in AD 718 624 131450 PMC11034561__F2 HTRA1 can affect BrM morphology through cleavage of ECM (Fibronection) 5654 7448 2202 961 7040 4087 4088 392255 PMC11036006__F4 Diagram of “component-target-pathway” 7498 3362 5580 3558 3351 8654 43 3320 983 5144 1565 835 1991 1956 7124 1812 834 7422 351 231 208 5743 759 2246 6093 5578 768 151 841 4321 7442 152 840 2247 207 50507 1909 10855 6774 5243 4313 3356 839 4322 1813 3357 3791 6097 3958 PMC11037416__F5 Pyroptosis mediates macrophage reprogramming of the tumour immune microenvironment 7097 7099 3146 920 3002 3001 6774 1687 55876 114548 56169 79792 PMC11039397__F7 Mechanism diagram of SR1 alleviating bone lossIn the natural environment, air pollutants contain different AhR ligands 7189 9049 196 8195 57491 405 4772 1513 54 81501 245972 PMC11040418__F2 Network pharmacological analysis of chondrocyte apoptosis modulation by RJNTF 5594 23411 142 6714 2932 5300 2146 2033 25 3725 3066 351 5829 10013 2316 1956 6233 3383 367 408 2885 4087 7189 6152 3308 4609 4088 7534 9641 4174 7531 8451 409 3676 3609 4171 2099 2130 5970 4193 7275 7157 23524 26986 7514 4792 60 7316 4790 6187 6134 6790 9820 203068 4914 4214 11338 2335 3312 1017 6045 7412 8452 7428 7415 2521 83987 4843 10987 1213 23363 1660 6118 8454 6119 55832 4691 3192 6117 6188 3315 5684 22938 9531 988 8453 6202 9775 4738 3627 2920 6347 3091 6401 3569 3659 3553 5743 7124 PMC11040904__F2 Regulatory pathways governing PD-L1 via phosphorylation and ubiquitination 120892 3716 142678 1950 3703 324 841 7128 54941 3434 8405 1019 1021 9099 83590 10075 54918 10273 146223 PMC11040904__F3 Negative regulatory pathways of PD-L1 mediated by other posttranslational modifications 324 23376 51569 4318 4322 4316 9636 51147 80854 PMC11040904__F4 Regulatory pathways of PD-L1 via deubiquitination 324 55611 10130 23326 9101 158880 7874 257000 8078 8239 9099 10868 11274 7345 PMC11040904__F6 Positive regulatory pathways of PD-L1 mediated by other posttranslational modifications 10954 382 324 2194 51304 51114 1950 3066 PMC11040904__F7 Posttranslational modification of PD-1 4193 3932 2530 8078 1154 81545 1977 PMC11042222__F4 Loss of Ffar4 is associated with decreased AMPK signaling and increased cellular senescence in the infarcted myocardium 25886 1149 355 3630 3135 3732 5728 4361 10111 472 545 1017 1019 2626 90550 59341 PMC11043956__F7 SSYYJN ameliorates CKD-induced muscle atrophy by inhibiting ferroptosis in tibialis anterior muscle cell via HIF-1A/SLC7A11 pathway 23657 6520 2879 PMC11043957__F1 Signaling pathways in radiation-induced lung injury 3490 4088 4089 4087 PMC11043957__F2 Nrf-2 and signaling pathways 3550 10454 4088 4089 4087 1728 PMC11044150__F10 Modulating the MAPK signaling pathway of LQZ against AD 1950 2885 7124 4615 7189 10454 2002 4149 PMC11044490__F6 DEGs in plant hormone signal transduction pathway 108348016 4881 51411 7018 64641 1879 PMC11046063__F1 NRF2 signalling pathway 9817 9978 8452 8454 PMC11046441__F3 Diversity of metabolic arrangements for Alpha-glucan and disaccharide pathways in the context of prokaryotes 4118 2638 4117 22944 PMC11046856__F1 Canonical Wnt/Beta-catenin signaling pathway 4041 4040 324 1499 PMC11046879__F2 Illustrates the functions of PTEN in the cytoplasm and nucleus 5728 9961 2475 1060 4171 5888 6117 51199 PMC11046940__F2 Mechanisms by which autophagy modulation affects chemosensitivity are multifaceted and involve multiple signaling pathways 64223 60673 9776 8408 9706 100170220 9474 55054 9140 10533 83734 64422 8878 PMC11047590__F1 Redox systems involved in microglia 9978 8452 9817 10628 1499 114548 23657 2937 57716 2879 PMC11047590__F2 Redox regulation of immunometabolism in the polarization of microglia in DR 6649 7099 5728 5209 6009 2242 2475 3383 4803 PMC11048169__F1 Main signaling pathways within cancer cells 1956 2065 2066 2885 8821 472 545 5728 4214 4193 4133 6416 7249 2308 9776 3725 1019 1021 4609 2353 581 596 4170 PMC11048169__F3 Information exchange and signal transmission between cells within the tumor microenvironment 468 83939 7186 384 3565 3569 6935 7494 4853 4854 4851 4855 3717 3716 445 6347 942 3458 7939 7124 729230 3002 7535 27040 PMC11048329__F2 Schematic presentation of current evidence on Cx32 association with EMT and the HCC chemotherapeutic resistance with oxaliplatin or doxorubicin 619501 999 1499 PMC11048531__F2 Combination of DSF/Cu and chemotherapeutic drugs sensitizes breast cancer (BC) cells and their stem cells by targeting various cellular and signaling mechanisms 283871 581 50943 960 100133941 6774 PMC11048596__F4 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma 100187907 650 11167 9350 6206 5788 3921 51284 914 6693 PMC11048596__F5 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma 3921 6143 10023 1488 6206 27122 650 1643 6142 729 11167 4193 3400 1870 7132 6515 23764 100187907 PMC11048596__F6 Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma 11167 324 10023 1499 4193 650 4086 4090 4089 9350 PMC11049012__F1 BCG-driven activation of the bladder cancer TME involves the NFKB/TNFA signaling pathway and IRFs/IFN pathway 4513 7124 6352 4283 3627 6373 51199 3576 6387 6367 PMC11049046__F5 KEGG pathway of the MAPK signaling pathway with target genes of our known miRNAs shown in red stars and targets of novel miRNA NC_060925 4351 695 6722 4149 2316 79633 7124 8717 7186 435 355 1616 4208 929 23118 51295 1610 51701 1950 PMC11049046__F6 KEGG pathway of the PI3K-Akt signaling pathway with target genes of our known miRNAs shown in red stars and targets of novel miRNA NC_060925 2475 6009 7249 2885 613 6850 930 951 5934 572 4602 PMC11049089__F1 Signaling cascades of TLR4 and TLR2 receptors 23643 4615 51135 3654 7189 4049 5879 64127 10392 8767 207 3661 3663 2353 3725 7124 8651 PMC11049334__F2 Polyphenol-target network and associated signaling pathway and biological function 5594 5743 4792 4843 4790 7124 4318 PMC11049885__F2 Network comprised of the IRs affecting ecdysone synthesis 3175 1610 1019 231 26019 3043 92689 112812 3048 7054 8626 9039 3047 4129 4653 6646 1798 221 4665 199857 10682 1718 5295 6309 85358 684 1595 6721 224 79001 2675 6184 51606 10427 2027 5598 23556 9477 5519 6249 10026 3064 54797 5501 8636 1453 64983 115106 84131 196441 22981 65080 81618 PMC11049885__F3 Network comprised of the IRs that compete with ecdysone synthesis 5519 1595 2027 81618 1718 6184 6646 1019 10682 6249 5501 221 3047 112812 1453 8636 115106 196441 9039 3043 231 54801 5598 26019 7054 92689 84335 4665 22981 5295 84131 4653 3048 8626 64983 54797 23556 199857 1798 3175 1728 4129 224 80339 9477 29914 6721 65080 10427 PMC11049885__F6 Key IRs significantly affecting ecdysone synthesis 112812 6721 6309 10682 PMC11049935__F5 Plant hormone signaling pathways and related DEGs 7018 64641 1879 51411 PMC11050151__F2 Representative scheme of the 15 genes shared by the selected pathways using pathway enrichment analysis 5788 3710 5294 5296 5880 4773 2353 5743 PMC11050151__F3 Gene association networks that result from entering the list of eight genes—PIK3CG, PTGS2, FOS, PTPRC, VAV1, ITPR3, NFATC2, and PIK3R2—as input into the GeneMANIA software 3710 50943 5296 916 4773 29850 5730 6916 917 55824 7006 100124696 915 7409 3727 2549 5879 3815 867 1956 5293 5294 5530 5788 23533 3725 5743 2355 468 2353 5588 5290 5742 5740 146850 10507 3490 23135 PMC11050203__F1 Activated signaling pathways: (a) the Wnt signaling pathway is activated in the presence of Wnt 2475 4041 324 1499 4193 PMC11050207__F4 Significantly altered KEGG pathways in LAPST versus CPG group comparison 2885 4352 2316 7124 8717 7186 4615 355 1616 23118 4149 4208 6497 1977 6009 2475 7249 672 5879 6850 373073 5934 5728 572 150365 PMC11050257__F3 Representation of the diversity of the AP-1 family of TF 3726 10538 2885 998 5058 1386 4208 PMC11050262__F8 Gene expression changes in GO terms: (A) base excision repair, (B) mismatch repair, and (C) homologous recombination pathways in response to high–THC extract #18 compared to DMSO control in the HT–29 CRC cell line 4436 4437 5890 641 472 1311 150365 675 79728 5091 PMC11050262__F14 Cytotoxic effect of cisplatin on the HT-29 cell line based on gene expression and pathway analysis 4553 637 572 317 PMC11050296__F10 Scheme showing the mechanism of olive-derived secoiridoids that regulate melanogenesis signaling pathway 4157 1499 4286 1638 PMC11052371__F3 Pathogenesis of acne and the mechanism of action of P 920 948 2255 2252 2263 1499 2475 5228 7412 3383 PMC11052502__F4 Results of PPI, KEGG, Reactome, and GO analysis of 19 common proteins that were targets of 1-MNA and RA-associated gene targets 3643 5170 1977 3932 2932 7042 142 5144 1017 1432 834 2159 1800 2946 4317 4314 331 4318 PMC11053014__F1 Model of Hippo sinaling pathway in mammalian cells and the activity of Hippo sinaling pathway controls the dynamic localization of YAP/TAZ between nucleus and cytoplasm 26524 9113 4771 4485 PMC11053014__F2 Molecular mechanism by which mechanical cues regulate YAP/TAZ 4771 4485 387 26524 9113 PMC11053446__F6 KEGG pathway analysis for DE mRNAs from cTECs infected with IBV DMV/1639 or IBV Mass41 1506 7098 10333 54472 7097 4615 8772 114609 3929 929 7099 23118 7124 7100 7189 958 941 942 1513 54106 7297 3665 3661 6773 PMC11053446__F10 KEGG pathway analysis for DE mRNAs in tracheal tissues from chickens infected with IBV DMV/1639 or IBV Mass41 1506 7097 5879 10333 54472 4615 8772 114609 4703 3929 929 23118 7189 5132 1513 130749 54106 7098 7187 3661 958 941 7297 10379 PMC11053886__F2 Signaling related to flowering 1408 574414 9575 2000 1999 80758 PMC11054595__F2 Mechanisms or pathways associated with sepsis-induced ALI 4615 7099 358 581 847 PMC11054859__F7 KEGG pathway (hsa04151 P13K-AKT signaling pathway) 2475 6009 7249 1975 5447 5934 572 613 930 5728 PMC11055311__F1 Main signaling pathways involved in TPL in cancer 6774 4318 4040 999 6425 11197 64321 8321 1017 5970 9698 PMC11055549__F3 Construction of the prognostic target-ingredient network 1019 5501 4860 768 7083 5347 5591 7272 9134 993 983 2539 7086 476 2768 3832 9133 890 6790 9212 891 PMC11055915__F4 Mitochondrial quality control regulates cell death induced by copper and iron 79792 11035 197259 8737 355 114548 8717 5132 9927 55669 2182 2230 2242 10162 2879 1737 PMC11055934__F1 Depicts the eicosanoid inflammatory pathway 5740 4513 1579 2638 1558 2053 PMC11056316__F9 Schematic illustration outlining the mechanism by which PIN operates during osteoclastogenesis 27035 7189 5879 4772 54 4318 245972 PMC11056900__F1 Molecular mechanism of mitochondrial dysfunction modulating the relationship between chronic liver disease 115004 3661 23410 114548 664 6772 90550 PMC11056900__F3 Mitochondrial and endoplasmic reticulum-associated signaling regulates the molecular mechanism of chronic liver disease 9927 6098 55669 22926 PMC11057055__F5 Identification of microRNA (miRNA) target genes 3479 3586 2697 2632 4086 1513 2294 3685 4089 1289 2353 3688 4092 1026 182 4628 6591 9315 5155 864 4087 4751 4088 5069 10210 5468 51422 23035 5728 55737 5743 4851 860 2247 595 6774 5339 6863 7046 2006 5141 4313 7026 2475 4627 3909 55975 5594 1958 8678 3091 27122 6387 10672 56963 1294 10163 3082 5803 7048 6102 8087 1290 10810 6326 3068 2335 1281 89780 2200 6497 2252 6667 1525 10413 7057 56848 9839 186 3576 1278 1277 7020 7077 55082 7168 7042 70 7157 7422 8626 10006 9618 1462 9509 59 114904 538 54829 1956 PMC11058197__F6 Proposed model of the Notch-ROCK pathway and its biological significance 3714 4851 3280 7097 7099 4843 PMC11058230__F7 A hypothetic model for signaling pathway alterations and cellular phenotypes in MPS II neurons 1499 8313 4316 4747 8061 6335 773 5024 10242 3751 PMC11058355__F2 Functions of Mincle 79595 5052 6850 64170 8915 10892 PMC11058607__F2 Pathways in HNSCC cells involving growth factor receptors like TGFB causing cell migration and invasion leading to metastasis 7048 7046 6885 8195 2475 PMC11061161__F1 T cell activation and subset differentiation and function by lipid metabolism 355 6820 948 920 6774 366 1374 PMC11061361__F3 LIPUS regulates chondrocyte function via multiple pathways 6714 176 6010 1490 4312 1499 1431 2475 6659 7077 7422 PMC11062136__F1 Graphical model illustrating the complex roles of Cytokinin Response Factors (CRFs) in the trade-off between abiotic stress response and plant developmental processes 3258 9575 878 5300 PMC11062289__F5 ENPP1 in Blood and Bone: Skeletal and Soft Tissue Diseases Induced by ENPP1 Deficiency 8074 4628 5167 7421 11197 6422 8325 PMC11063341__F1 Mechanism of Hippo pathway and the hippo targets of ncRNAs 4485 60485 100302183 652995 9686 7004 7005 7003 8463 378938 PMC11063508__F1 Schematic diagram of the entire study 920 836 891 545 1017 9134 1019 1029 54205 51512 4194 4193 5728 PMC11063913__F2 Regulatory mechanisms of WT1 in sex differentiation 7490 7536 6010 998 6662 268 PMC11064142__F10 TLR signalling leads to apoptosis in tumour cells 7099 3454 3455 114609 637 3716 7297 7098 8717 6772 6773 4615 8772 581 4170 7189 3654 51135 10379 7187 PMC11064142__F8 A) Interaction of mir15a/16-5p cluster and mir-7641 with targeted genes involved in intrinsic and extrinsic signalling pathways of apoptosis 581 406948 150365 4609 898 57659 1027 7422 144455 7094 4170 5111 5728 3725 595 596 3845 10018 PMC11064406__F3 Intracellular copper distribution pathways 9973 6647 475 540 538 10063 PMC11064406__F4 Molecular mechanisms of cuproptosis 540 538 1737 2230 11019 10063 PMC11064802__F1 Action of TCM prescriptions and natural bioactive molecules in atherosclerosis therapy by targeting peroxisome proliferator-activated receptors (PPARs) 9619 5465 19 51 1374 948 7097 7099 4615 PMC11064802__F7 Action of carbohydrates in atherosclerosis therapy 5465 2475 4615 64240 64241 29881 PMC11068999__F2 Wnt/Beta-catenin pathway 5925 1499 324 PMC11068999__F4 Hh signaling pathway 5925 1499 324 PMC11074409__F2 Activity of probiotics, synbiotics and postbiotics 3586 3565 7157 581 3458 3569 596 4513 1499 PMC11074473__F3 M5C methylation in innate immunity (By figdraw 59272 7097 7100 51311 7096 7099 85495 57506 55695 4615 115004 2879 3665 54888 3661 54106 51284 7098 PMC11076649__F8 JCYSTLF exerted an anti-senescence effect through regulating the HIF-1A/autophagy pathway in diabetic kidneys 9474 4397 55014 PMC11076692__F2 46,XX Testicular and ovotesticular DSD 7490 2516 6736 7026 1499 6662 668 1761 2263 2254 30812 6663 6658 54361 284654 PMC11076696__F3 GLP-1RAs in reducing macrophage inflammation and foam cell formation 50507 85451 2475 1051 114548 79792 PMC11076713__F8 Schematic model: The interferon and interleukin 27-dependent JAK-STAT signaling pathway 246778 3454 7297 10379 3455 3716 3717 6772 6773 6774 9636 3620 3669 51311 3428 51284 7099 115004 7098 7097 9447 81030 3434 3600 3569 9235 3574 6354 6352 6355 6347 558 952 6614 57823 941 942 958 972 567 3106 3105 4261 9021 3718 PMC11076734__F4 PINs-mediated auxin transport regulation during salt stress 5300 5303 6655 PMC11076791__F4 Proposed regulatory network 6615 56992 7471 2113 407043 2672 4838 3169 6469 8092 407047 1999 PMC11077368__F11 Schematic diagram explains the mechanism underlying by which SP protects against colitis 2879 23657 2182 115004 3627 PMC11077374__F1 LncRNAs in modulating the Wnt/Beta-catenin signaling pathway in pancreatic cancer 11197 100124700 105373869 100885775 26220 100423029 7153 285987 100505641 693142 399717 4040 54881 324 283120 286077 729082 2305 5820 90780 1487 11091 140828 55384 2309 3205 25798 1499 100316868 2308 100505633 2146 9589 8662 100288077 22943 PMC11077374__F3 HuR during Wnt/Beta-catenin signaling pathway, autophagy and drug resistance in pancreatic cancer 100288077 8662 1499 9589 10533 7465 3417 1633 PMC11077374__F4 FOXO1 and FOXO3 in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer 2309 140828 50507 23411 2308 1499 283120 10533 100124700 PMC11077374__F7 HIF in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer 112398 5223 6925 664 1024 81671 4089 PMC11077374__F8 FOXO3-FOXM1 axis in regulating drug resistance in pancreatic cancer 7347 2305 5245 960 5160 2309 PMC11077380__F2 Mechanism diagram illustrates the crosstalk between Se-AA metabolism and various cell types in the TME 2876 2878 355 3133 PMC11077654__S1 Cerebrospinal Fluid Dysregulation via a SPAK and OSR1 Targeted Framework Nucleic Acid in Hydrocephalus 942 1435 130497 PMC11079205__F1 Bone remodeling is a dynamic process that is completed with the participation of BMU 9242 5741 3479 PMC11079205__F2 The GM and gut hormones on bone metabolism 5697 7054 5212 3479 PMC11079205__F4 Incretin hormones’ effect on bone 5741 2695 5697 3479 2696 860 9340 PMC11079285__F3 TREM2 mediated immunosuppression and regulation of cancer progression 54209 1499 2932 PMC11079312__F8 Proposed lipogenic pathway regulated by MUL1 during conditions of HFD 4706 4726 79594 2194 PMC11079401__F2 MiRNAs in EMT regulation via TGFB signaling pathway in pancreatic tumor cells 8829 100129597 4092 64750 4087 4088 5894 4089 406909 100302188 387 1844 PMC11079401__F3 MiRNAs in EMT regulation via PI3K/AKT signaling pathway in pancreatic tumor cells 306 6286 10765 5163 2475 PMC11079401__F4 MiRNAs in EMT regulation via WNT and JAK/STAT signaling pathways in pancreatic tumor cells 4041 4040 283120 324 100033819 9655 100507463 9021 60674 54879 442903 1499 619556 PMC11082402__F5 Riboflavin metabolic pathway 645 55312 80308 PMC11082748__F4 Graphical representation of the CREB signaling pathway downregulated in the control group (see Figure 3A) 6464 2885 5894 6300 5594 814 6195 2002 1387 6908 2033 2959 PMC11082748__F5 Genes (N = 21) detected by IPA as involved in the neuroimmune pathway were entered into a representation using the GeneMANIA algorithm 2353 3384 1524 353376 1536 1520 7305 1432 2357 1441 3146 567 4615 3459 5606 4210 5730 5295 29108 3148 1436 3386 27035 90 5603 PMC11083344__F4 BCAR3 in cell cycle progression 998 9564 8412 387 6714 1019 1021 1017 PMC11083429__F1 When a DNA single-strand break (SSB) happens, poly (ADP-ribose) polymerase (PARP) guides SSB repair through NAD+poly(ADP-ribosyl)ation (PARylation) of histones and chromatin remodeling enzymes 6741 23476 472 672 580 79728 2177 7398 367 545 1111 1586 PMC11083682__F2 Influenza viral degradation of cellular proteins involved in the interferon responses 3459 3460 3454 3455 163702 7189 6048 57506 4077 54472 55611 7297 3716 3717 142 200933 10379 6772 8651 3661 1789 PMC11083682__F3 Influenza viral degradation of cellular proteins that do not directly regulate IFN signaling 1080 83737 4193 896 6647 4343 57762 2874 26270 79671 84181 5371 29101 1975 10410 6772 79885 9759 10013 3065 3066 PMC11083860__F8 FGF23/FGFR1cAklotho signalling pathway which mediates phosphorylation of NHERF1 9368 6446 6654 2885 10818 8074 PMC11084413__F5 KEGG pathway analysis of carnosic acid downregulated proteins associated with glycolysis/gluconeogenesis 218 2597 4397 2821 3098 3099 3939 5162 5211 PMC11084589__F2 Inhibition of pathway activity induces microglial cell state transition 7099 4615 5163 7474 7189 387 PMC11084589__F3 Increased pathway activity induces a shift from a neurotoxic to a neuroprotective state in microglia 7099 4615 761 7189 PMC11085255__F1 Molecular structure and signaling pathway activation mechanism of Nrf2 9817 10763 6256 84181 8452 PMC11085255__F2 Regulation mechanism based on Nrf2 signal pathway 9817 23411 2534 5163 5164 8841 581 2879 PMC11087094__F3 Four most related metabolic pathways in digestive system tumors 445 435 383 23464 5009 95 157739 10993 2744 5091 137362 122622 PMC11087724__F2 Leptin and insulin signaling pathways in the hypothalamus of chickens regulating neuropeptide genes (created with BioRender 3667 3717 6774 5163 2308 5443 9021 4852 PMC11088914__F3 The interaction of the lipid pathway with other signaling pathways for the regulation of pluripotency 4838 652 3481 2247 2885 10818 4086 4090 4087 4089 5310 6926 4609 6657 79923 6929 324 1499 PMC11089157__F4 Post-translational regulation of FOXK2 472 3607 2475 2309 51588 23411 5631 790 PMC11089157__F5 Emerging roles of FOXK2 in cancers and metabolic disorders 3607 2146 5978 25942 8314 7428 10628 PMC11091328__F1 Regulatory mechanisms of SIRT1 on ER stress and NFKB signaling pathways 7494 23411 22926 2922 468 PMC11091639__F8 PD-L1 regulatory signaling pathway [23] 6772 4615 7189 5728 PMC11092382__F2 Antitumor effects of sophocarpine through multiple signaling pathways 1000 4318 23462 3280 2475 5728 PMC11092636__F3 Exercise activates the EGFR/insulin signaling 6812 5590 1398 5578 351 761 759 5781 1432 2997 53358 7249 2475 2889 3643 5607 7786 10580 208 5604 9020 5580 23433 9882 5602 6616 6416 5728 PMC11095602__F2 Senescence-associated lymphoma progression and drug resistance 2146 695 2475 4615 10257 3718 3717 6774 2626 4609 79923 6657 PMC11098888__F4 CCL1/CCR8, CCL3/CCR5, CXCL6/CXCR2, and CXCL12/ CXCR4 axes in esophageal squamous cell carcinoma 1234 6348 3579 6372 7852 6387 1237 6346 51083 6714 5728 6010 PMC11099588__F1 Biological functions of Amot family proteins and associated signal transduction pathways 10413 4734 64398 55114 10207 154810 51421 154796 64236 1003 4485 253260 2475 PMC11101339__F5 Main mechanisms of therapy targeting TME in SMARCA4-UT 355 324 920 4283 3458 2146 PMC11103046__F1 Cardioprotective Mechanisms of SGLT2 Inhibitors Against Cancer Treatment–Induced CardiotoxicitySodium-glucose cotransporter-2 (SGLT2) inhibitors protect against cardiovascular toxicity induced by anticancer drugs via multiple mechanisms 468 2475 27035 1728 114548 PMC11103046__F2 The Anticancer Effects of SGLT2iSGLT2 inhibitors (SGLT2i) inhibit glucose uptake by inhibiting SGLTs (SGLT-1 and SGLT-2) and glucose transporters (GLUTs) 7076 1956 2475 3169 3190 10413 6469 PMC11103502__F9 Pharmacological activation of the HIF pathway improves the ischemic tolerance of brain-resident cells by reprogramming of glucose metabolism 847 2821 2597 5163 PMC11106351__F9 Anti-hepatitis B virus mechanism of dopamine 619511 3972 6772 9636 1812 PMC11106741__F1 Esc in cancer cells was revealed to be related to apoptosis, which is governed by the mitochondrial pathway, ER stress and ferritinophagy 4780 2879 2495 7494 22926 6668 6667 PMC11107893__F1 Molecular targets and therapeutic interventions in non-small cell lung cancer treatment 1956 238 5979 27436 3845 673 1019 1021 2475 6098 PMC11117599__F3 Anti-fibrosis mechanisms of H2S 4088 4087 6778 4089 PMC11117599__F5 SO2 exerts its antifibrotic effects by modulating key intracellular signaling cascades 4485 1499 7076 PMC11117611__F6 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases 23327 4734 5728 3480 302 10628 2203 4312 PMC11117976__F1 TLR and NOD receptor-mediated immune response 10392 64127 7189 10628 8767 8011 10454 114548 PMC11117976__F5 M2 macrophage polarization 6778 3662 383 57716 6647 4353 PMC11118191__F2 Overview of USP36-mediated signaling pathways 4485 6648 4193 57602 26524 9113 80254 8087 3099 27063 142 PMC11118937__F1 Nrf2 signaling in mitigating heat stress and xenobiotic-induced oxidative distress and apoptosis 8452 9817 847 PMC11119800__F1 Involvement of OGT in hepatic cellular stress 8473 8408 11035 2475 197259 83939 1998 PMC11119800__F3 OGT contributes to the progression of NAFLD 2168 2308 8473 355 7965 23411 7494 142 23410 PMC11119800__F5 Biological function of OGT in HCC 1977 177 875 2475 1499 8473 5903 860 3170 10524 999 4323 4318 11035 PMC11119900__F3 PAI-1 alters TME and regulates tumor cell migration and invasion 4035 5159 780 5340 PMC11120013__F4 CP-derived RONS promote cancer cell autophagy and death by activating the mitogen-activated protein kinase (MAPK) family signalling pathways 1356 9474 596 581 1687 PMC11120359__F1 Representation of the signaling pathway in the activation of CXCR4 (left) and ACKR3 (right) 6387 7852 2475 57007 PMC11120667__F11 Proposed model of the mechanisms of action of male M 355 1956 7442 8772 841 581 836 842 468 PMC11120667__F12 Proposed model of the mechanisms of action of female M 355 8772 841 5163 1956 7442 581 836 842 468 PMC11121000__F1 Insights into Salinity Tolerance in Wheat 10533 847 1178 PMC11121230__F2 SHIP1 and SHIP2 in the PI3K/AKT signaling pathway (created with BioRender 5728 5170 7248 7249 6009 PMC11121235__F8 N-glycan metabolic pathway 79868 54344 8818 440138 79796 7841 23193 PMC11121563__F4 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review 284551 10963 128439 607 PMC11121637__F1 Schematic representation illustrates the role of miRNAs in the regulation of FOSL1 999 8061 407040 407042 PMC11121637__F4 FOSL1 in promoting drug resistance and radio resistance 8061 1849 8682 3691 PMC11123779__F5 Protein–protein gene network in RA-infected ducks 5733 2922 4319 57576 4313 4688 948 2170 1390 1843 6372 3902 2686 467 1051 6351 6347 6363 29126 6361 51554 3598 4311 4982 8792 920 3656 3586 3046 1154 53335 3460 3665 4792 329 55601 10379 683 11341 11274 91543 80149 5783 64332 351 151056 6385 10144 4843 5009 9583 57689 84628 5092 7416 2934 5241 7124 PMC11123998__F5 Supplementation influences the metabolic reprogramming of cumulus cells in aging ovarian patients 3099 2821 3417 3418 8803 48 50 6389 6390 2023 2026 1431 2271 4190 3939 3945 5162 PMC11124422__F2 Mechanism by which APS induces apoptosis in cancer cells by interfering with the cell cycle, inhibiting signal transduction pathways, and inducing apoptosis 406991 9021 7099 114609 4615 7189 9618 4088 6774 5970 108348016 1499 595 581 1019 1021 2475 PMC11124422__F3 APS on ICIs, CAR-T therapy, and DC cancer vaccines within the TME 941 920 2475 PMC11125340__F7 Platelet-Derived Growth Factor Receptor Beta and JAK2/STAT3 Pathway 6774 3717 6010 5159 2623 1017 983 891 595 898 861 PMC11125634__F3 Schematic representation for DOCK11 and its partner AGAP2 regulating ARF1 activity to facilitate HBV retrograde trafficking 1956 139818 116986 375 PMC11125634__F4 Proposed hypothesis explains the mechanism for the role of DOCK11 in HBV cccDNA formation and its modulation of histone modifications and RNA Pol II on HBV cccDNA 998 139818 1283 545 51567 5111 PMC11125855__F3 Inhibition of DNA-sensing pathways by KSHV viral proteins 115004 100187761 9447 10111 4361 64170 3661 3665 3428 PMC11125956__F7 T helper 1 Activation Pathway 246778 3606 925 23308 942 941 3458 2885 29851 7409 5588 3454 9466 8651 8809 3824 3821 5608 29126 3965 84868 9021 3569 30009 6774 6772 6775 2625 4783 406938 406991 406947 407021 100885789 1234 920 325 3558 2833 8600 PMC11125956__F8 T helper 2 Activation Pathway 3565 958 7292 28514 940 2885 920 3689 29851 7409 5588 85480 90865 7293 9021 7040 6775 1234 79365 717 864 4094 30009 1108 3725 10320 11009 1901 1230 1232 1233 1237 7852 10663 11251 386653 PMC11125956__F11 Osteoblasts in Rheumatoid Arthritis Pathway 11197 650 3479 5741 7124 3589 3569 7040 89780 4982 1435 860 4035 1855 659 4091 6714 4093 4086 4090 57154 4089 1452 324 10297 8312 2932 596 121340 249 6696 1277 632 27123 1749 PMC11125956__F13 B Cell Receptor Signaling Pathway, KEGG 933 971 6850 613 4067 695 640 55024 29760 2885 25780 8915 975 930 2638 PMC11126064__F8 Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis 847 581 1728 7124 PMC11126959__F3 Autophagy pathway 10645 2475 8408 9140 9474 55054 9342 PMC11126959__F4 Impact of sustained changes in cardiac O-GlcNAcylation 7494 468 6262 1375 10724 8473 6667 9759 5978 2475 PMC11127239__F2 Cytotoxic effects of deoxynivalenol (DON) and mechanisms of diarrhea induction 1080 114548 2512 PMC11132832__F5 Hub target-pathway network (67 nodes and 95 edges) 7054 3458 7040 110231149 PMC11134594__F2 TGFB signaling pathway: Integrins release TGFB by binding to LLC on ECM 4087 4088 4089 PMC11141153__F6 AMPK signaling pathway depicted using KEGG in tissue lysate fractionThe levels of upregulation of the proteins observed in AMPK pathway are as follows: CAB39/MO25 log2 0 2147 51719 9370 1080 5519 355 948 3479 7249 3630 3643 5163 5164 6009 2475 PMC11141639__F1 Winer et al 3716 4609 5347 PMC11144369__F1 Outlines of the AhR signaling pathway 196 9049 6714 405 57491 1544 1545 1728 4513 PMC11144369__F2 FICZ-induced, AhR-mediated skin carcinogenesis from UV radiation 196 9049 1956 405 1543 PMC11149107__F1 HER3 targeted therapies in the clinic and HER3 downstream signaling pathways 1956 3480 2885 6714 5163 5728 2475 PMC11153983__F6 Illustration of the mechanism of DHA inhibiting T-ALL cell viability, inducing ferroptosis by modulating the SLC7A11-GPX4 signaling pathway and provoking ER stress 23657 6520 2879 468 PMC11155398__F2 Biological significance manipulated by SUMOylation in tumors 81847 6612 10644 7341 3607 51588 165918 8554 29843 10155 22880 1457 PMC11155398__F4 Biological functions of SUMOylation cascade in tumors 8535 6612 81847 3659 6737 9589 56339 57721 7341 79068 51441 10155 10055 PMC11161882__F3 Differentially regulated pathways obtained from IPA analysis A 54345 1964 55638 27299 6652 4681 6122 PMC11171484__F4 Systemic inhibition of TGFB signaling in the fibrotic lung by pirfenidone and localized inhibition of TGFB signaling in the fibrotic niche by bexotegrast (A,B) 4087 4088 4089 1281 7076 115908 PMC11172074__F1 Effect of miR-21 on the PTEN/AKT Signaling Pathway 1956 2885 6714 5728 5163 PMC11172503__F1 Nrf2 and NFKB signaling pathways by royal jelly (RJ) 7124 4015 4513 4313 4318 4094 847 1728 260431 PMC11172503__F2 Anti-senescence effect and molecular mechanisms of royal jelly (RJ) and its components on cellular senescence, healthy aging, and longevity induced by endogenous and exogenous factors 472 545 1017 1019 1021 PMC11172744__F7 After TCR stimulation, two signaling pathways are induced via 3,4,5-triphosphate (IP3) and diacylglycerol (DAG) 7535 27040 5335 83440 2820 PMC11172800__F3 Significantly, DE genes (identified by KEGG) were involved in the bacterial invasion of epithelial cells signaling pathway during 8-week S 3688 126669 26052 1496 858 23607 1398 5747 3611 5293 391 6010 998 7454 10092 PMC11172918__F3 Different signaling pathways activated by the binding of CGs and ROS to NKS 1956 6714 2475 4827 84876 6786 PMC11172918__F4 Ouabain–NKA-induced changes in epithelial cultured cells MDCK 6714 2475 59341 PMC11173094__F3 Natural products that modulate specific proteins in the molecular pathway of inducing and inhibiting ferroptosis 150696 3658 2512 2495 8031 9474 10533 84557 81631 94033 9131 30061 7417 1356 4780 10413 3162 4891 4057 7018 7037 467 468 25937 239 59344 4734 23657 6520 7296 7295 2729 2937 84883 246 5447 6303 1803 7157 2879 2936 6667 7022 3091 2034 2182 29923 10162 PMC11173095__F3 VEGF signaling pathway 10818 2444 6714 2885 6461 2932 2475 PMC11173247__F8 Wound-induced genes involved in plant–insect interactions in arabidopsis WT and lox2 mutants 57139 4602 4609 57716 PMC11173325__F1 The mTOR signaling pathway and the cellular functions driven by the formation of its two main complexes, mTORC1 and mTORC2 3667 5728 5163 9675 64798 7248 7249 6009 6446 PMC11173325__F2 Roles of mTORC1 and mTORC2 in regulating metabolic diseases, cancer, and aging 197358 5045 3667 1977 5728 7038 PMC11173950__F3 Oxidative stress: Nrf2 signaling pathway (adapted from Hammad et al 9817 8452 9978 PMC11174683__F3 Mechanistic map of signaling pathways associated with NPs for liver cancer treatment 3717 6774 4485 283120 1499 5111 2119 2635 2475 8313 581 595 960 999 6469 PMC11174690__F4 PI3K-Akt signaling pathway by active ingredients in goji berries 596 581 3929 2475 5728 2308 114548 PMC11174838__F3 Resistance Exercise and Essential Amino Acid Intake on Muscle Quality, Myokine, and Inflammation Factors in Young Adult Males 5163 2475 7124 PMC11174978__F3 Understanding Fibrous Tissue in the Effective Healing of Rotator Cuff Injury 2932 1499 4089 324 4323 1278 4316 4087 4088 1277 1281 PMC11177172__F5 Regulatory associations between protein-protein networks, based on the IPA Knowledge Base 7706 2171 23435 79026 1964 6726 6203 6209 6210 6206 6204 1356 3146 873 5092 PMC11185840__F2 Sphingolipid metabolic pathway 1674 64781 7368 9514 PMC11186353__F4 Illustration representing the sites of action of different polyphenols in cancer pathway 5340 7077 5888 PMC11186373__F8 Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12 6446 6539 79792 PMC11187369__F4 Druggable toll-like receptor (TLR) cascades 51284 51311 54106 4615 8411 114609 695 PMC11187922__F9 The main findings in this study 4192 9242 4035 6696 4256 PMC11188434__F0 GUP can effectively inhibit the activation of cGAS-STING pathway induced by multiple stimuli and reduce the expression of type I interferon and pro-inflammatory cytokines 115004 3661 4280 7124 PMC11195429__F2 CGAS-STING signaling pathway 5167 11277 1776 9654 284076 10524 10419 142 84243 59343 57337 115004 23252 10475 1613 10107 57558 7124 PMC11200741__F3 Outline of the Hippo signalling pathway 60485 26524 9113 4609 PMC11200880__F1 Oxytocin signaling brain pathway 5020 57468 7442 1956 5021 3769 5598 5894 4139 7099 83939 5997 116 PMC11200984__F6 Action of Isoflavone Derived from Soy-Based Tempeh as an Antioxidant and Breast Cancer Inhibitor via Potential Upregulation of miR-7-5p: A Multimodal Analysis Integrating Pharmacoinformatics and Cellular Studies 142 1956 3480 4363 983 6098 581 4089 4087 4088 2475 6774 5728 PMC11201249__F2 Schematic presentation of mTOR modulation pathways 5163 7248 7249 2475 8131 9681 10641 PMC11201617__F2 Canonical activation of the WNT/Beta-catenin pathway 1499 2932 324 2752 6926 4942 389058 8549 PMC11201617__F3 Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview 4313 4318 6591 332 598 PMC11201617__F4 Hippo signaling pathway 4771 4485 60485 26524 9113 PMC11201617__F6 Notch signaling pathway 8788 65989 51162 92737 3280 6662 595 PMC11201634__F1 Canonical Wnt signaling pathway 4041 4040 324 1499 PMC11201634__F4 An illustration of the specific Wnt signaling pathway associated inhibitors that have been studied in preclinical and clinical trials for pediatric tumors 64840 4041 4040 324 1499 PMC11201890__F2 USP5 participates in immune regulation through a variety of signaling pathways 8078 2305 1499 114548 7189 PMC11201989__F8 Working model for PD-L1 in the regulation of ciliogenesis 2735 90410 4218 129880 9742 2737 PMC11202101__F1 Interleukin-17 signaling pathway (Kyoto Encyclopedia of Genes and Genomes (KEGG) ID: Human (Homo sapiens), hsa04657) 920 7851 8178 8717 8772 351 7054 23118 3576 2920 6374 6364 6278 7124 PMC11202538__F1 Canonical Shh signalling pathway 6469 5727 374654 51684 6608 2736 2735 79923 6657 PMC11202538__F2 Crosstalk with the Shh signalling pathway 6469 5727 6608 51684 7248 7249 5728 6009 324 2736 2735 1499 6657 79923 PMC11202538__F3 Targeting the Shh signalling pathway regulators 6469 6608 5727 2736 2735 51684 79923 6657 PMC11202552__F2 Simplified diagram of the insulin signaling pathway 5879 2308 5140 355 PMC11203709__F3 VHL-mediated signaling/regulatory pathways in ccRCC with respect to PAX involvement 654433 7428 4087 4088 4092 4609 64750 7849 2932 324 2475 5076 57556 1499 595 PMC11203986__F8 NAP1L1-associated pathway 4673 3068 1019 1021 595 PMC11204038__F1 Schematic diagram showing the NAD+ metabolic pathway 27231 54981 1571 10135 4837 23411 PMC11204099__F8 Chlorogenic acid and cinnamaldehyde synergism on Akt-mediated signaling pathway downstream target proteins 5163 4318 1000 999 PMC11204236__F11 Proposed model illustrating the network of molecular mechanisms governed by miR-1 during early differentiation of the cardiac sinoatrial region 4208 801 5469 9611 6910 2626 PMC11204910__F1 Heme biosynthetic pathway in erythroid cells and the role of ATP-binding cassette transporter B7 (ABCB7 gene): The first enzyme of heme synthesis is 5-aminolevulinate synthase (ALAS2), which is the rate-limiting enzyme 210 54539 212 51218 51312 2242 3313 150274 22 PMC11206589__F2 Suggested anticancer molecular mechanisms of bromelain 960 581 1019 1017 983 PMC11206589__F3 Suggested anticancer molecular mechanisms of sulforaphane 581 960 5728 1019 1021 1017 847 2729 3553 PMC11206721__F1 Nutrition-related signaling pathway leading to diabetic nephropathy 6648 23411 2309 9844 23410 2475 5465 355 PMC11206879__F3 Alterations in major signaling pathways that have been identified in OS development and metastasis: PI3K/AKT/mTOR, JAK/STAT, Wnt/Beta-catenin, NOTCH, Hedgehog/Gli, TGFB, MAPK, and receptor tyrosine kinases (RTKs) 4092 4091 4089 4088 3280 6774 2475 6469 5728 51684 5727 847 2885 6608 4041 4040 7425 PMC11206888__F7 Diagram of PI3K–AKT signaling pathway 2475 1977 51083 7249 3667 930 951 5728 4609 5934 572 150365 4193 PMC11208996__F1 Schematic graph illustrating the TGFB/Smad signaling pathway and its roles in the regulation of various biological processes during chronic kidney disease 4050 4089 4087 4092 4088 7006 100124696 50943 PMC11209433__F5 Interactions among genes involved in the type 1 interferon signaling pathway using STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) 27179 132014 4311 6356 133396 112744 6401 2919 9547 2920 26525 84639 2882 8972 3067 26270 386653 1359 57007 9034 51176 1440 6347 2833 6373 79368 3434 4599 3627 54106 643 2921 50943 2829 5743 27035 4790 259197 867 7187 8638 727 4940 91543 3437 9636 55072 50852 6916 4214 3122 117854 PMC11210914__F1 Ferroptosis 23657 7037 4780 2879 5447 2182 84883 2643 1723 4257 PMC11210914__F5 Mitophagy in ferroptosis 65018 139341 94033 10059 PMC11210914__F7 CMA- or TAX1BP1-mediated GPX4 degradation in ferroptosis 23657 8887 2879 3920 3312 6609 5641 2475 1152 PMC11220218__F1 Metabolic reprogramming in thyroid cancer and therapeutic resistance 2539 6470 23152 2475 673 PMC11222861__F8 Brief proposal model of altered epigenetic regulation mechanisms of histone H3K27 acetylation causing FLHS and a summarized workflow of comparative analysis of fatty liver disease among different species 4915 3815 337 256691 83729 312 5105 PMC11232665__F2 Intervertebral disc degeneration 3667 2475 4314 4322 23410 467 PMC11232665__F3 Mechanism of metformin in intervertebral disc degeneration 9242 3146 9342 115004 PMC11232665__F4 Metformin likely acts on intervertebral disc degeneration through SIRT-related signalling pathways 23411 23410 65018 6648 PMC11232677__F7 KEGG pathway analysis of differentially expressed genes on cell cycle pathway in AML patient group with high beta-catenin levels vs controls 546 1663 25836 5885 23383 5347 23063 4089 7272 9232 6502 8190 8379 9319 9184 996 991 5111 993 995 994 3732 891 1017 1022 9133 90381 27085 8318 990 1869 924 10926 8556 8555 PMC11232677__F8 KEGG pathway analysis of differentially expressed genes on signaling pathways regulating pluripotency of stem cells in AML patient group with low beta-catenin levels vs controls 100653366 3716 6774 3976 3977 8503 4838 4089 6657 6926 4090 1852 652 659 6929 324 7976 79923 6498 3479 1499 5978 55183 PMC11234204__F1 Canonical mechanism of ferroptosis 7018 55240 8031 2181 2182 10162 6520 23657 81539 6510 27165 246 2879 2936 1723 2643 PMC11234204__F3 NRF2 is involved in preventing lipid peroxidation and ferroptosis in HCC 6520 23657 10998 64881 252995 706 23411 9817 2879 51094 10643 10814 80184 2954 5768 1728 2936 2495 PMC11234204__F4 Metabolic dysregulation mediates ferroptosis in HCC 27198 6520 23657 56902 587 6319 10999 6773 1717 10430 2879 PMC11234204__F5 Regulatory factors involved in sensitivity and resistance to ferroptosis in HCC patients treated with sorafenib 3934 493856 3977 6774 6520 23657 8678 4170 10127 84933 26528 2879 2194 8644 468 2182 4771 6319 999 PMC11234216__F3 Signal mapping of transcription factors regulating the fate of HPCs 3172 6662 1499 PMC11234281__F2 Piezo1 located in different cells regulates bone formation 3240 4397 5530 387 6093 56975 4854 4772 50964 1499 650 1758 2475 1906 7422 864 9780 860 4982 968 941 7057 4615 PMC11240352__F1 Genetic and nongenetic mechanisms of CRC resistance to cetuximab 1956 5728 673 6935 999 3082 3480 PMC11240352__F4 Cetuximab mechanism of action and summary of how RAC1 and RAC1B could contribute to the known mechanisms of cetuximab resistance in CRC 1956 5879 3480 4314 999 5058 PMC11240421__F13 CK1A interplay in the NFKB pathway 4615 3654 51135 7189 1540 23118 257397 8915 10892 5970 4904 8717 7188 7186 8737 9825 90268 PMC11240502__F1 Effects of UVA and UVB radiation on skin tryptophan lead to pro-inflammatory pathways 1956 196 4513 PMC11240630__F1 Pathways associated with the signaling of BCSCs 6608 2932 324 2475 PMC11240800__F2 Abnormal signaling pathways contribute to the pathogenesis of uLMS 6608 6714 2885 51684 PMC11241432__F3 MyD88-independent signaling pathway 4118 4615 51135 3654 7189 10454 23118 257397 PMC11242417__F1 Macrophage origins and biological functions 7124 367 613 383 PMC11242417__F3 Signaling pathways of macrophage polarization 7099 3717 7297 3716 3718 8651 9021 51135 7189 6774 6775 4088 6772 6778 4851 383 PMC11242587__F1 Association of type 2 diabetes mellitus with cancer, for example, pancreatic cancer 999 3479 3643 2475 6774 PMC11242595__F2 TGFB Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities 7189 55000 6714 6774 PMC11244889__F8 T3SS triggered LTB4 synthesis differs between neutrophils and macrophages 3055 4067 2268 6850 114548 8935 834 79792 6786 4050 PMC11251740__F1 Clinically relevant dysregulated pathways in GBM 1956 5156 4763 1029 5728 4193 1019 1021 2475 PMC11257078__F3 Bile acid regulation of the autophagy-lysosome axis 9965 2475 7942 9474 3988 PMC11257078__F4 Bile acid crosstalk with sulfur amino acid metabolism 1036 51380 1581 PMC11263586__F5 HPV perturbs DNA damage response signalling pathway 3014 10111 5888 5884 3364 84126 472 545 9656 11073 PMC11266911__F2 Molecular mechanism of antitumoral properties of 6‐shogaol 891 993 581 331 3550 6774 999 1000 595 5111 896 207 208 2475 4851 3280 PMC11273247__F11 Sodium sulphate ameliorates hypercholesterolemia and hepatic insulin resistance in mice fed an HCD 3667 5163 1581 2264 PMC11273248__F1 Flavonoid compounds exerting protective effects against brain injury after ICH 7189 581 836 114548 1728 834 PMC11273248__F2 Flavonoid compounds exerting protective effects on SAH 10365 23411 114548 1728 834 581 836 PMC11274091__F3 Interrelationship of major pathways and coexisting inflammatory mediators between oxidative stress and inflammatory process in excisional skin wound healing 5966 114548 4025 4353 3569 4513 3586 1401 847 PMC11274159__F2 EBV-affected signaling pathways associated with ferroptosis 30061 7157 23657 6520 467 2177 8031 2879 1026 1803 5447 6303 1994 8678 PMC11274344__F6 The cancer antioxidant regulation system in therapeutic resistance and scientific questions to be solved 6510 23657 6536 2744 2730 2729 2937 9817 2746 3417 3418 3297 4199 4200 10873 133686 2936 3845 10797 4522 10840 23530 PMC11274390__F1 Zn and Cu in the synapse under physiological and pathophysiological conditions: (A) Roles of Zn and Cu under normal physiological conditions 351 4504 538 PMC11274428__F1 The PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma 3091 5728 7248 7249 64223 2475 64798 4193 PMC11274491__F7 Proposed scheme for the anti-angiogenic activities of PZ-DHA 2932 2475 896 5728 5163 998 6010 PMC11274515__F3 Various natural compounds (EGCG, emodin, quercetin and crocin) inhibit HCC through interconnected signaling pathways 2475 619501 7124 PMC11274597__F1 Outline of the HH signaling pathway [16] 6608 51684 374654 2736 PMC11274695__F3 Interacting proteins in the classical cell signaling pathway validated using BiFC 10553 10211 5355 5911 80194 2014 7189 84962 324 4137 1499 7444 4431 64422 27101 4615 3586 55509 2353 595 1029 4609 PMC11274695__F4 Protein interactions in plant hormone pathways confirmed using BiFC 56987 1879 5524 381 5252 375 23179 30846 10938 338386 1312 PMC11274826__F3 OPN in the regulation of various signaling pathways 1956 3091 6935 9839 6774 2475 673 468 554210 1499 999 PMC11274826__F4 Diagrammatic representation of multifaceted function of OPN in various tumors 3611 960 2475 11166 79923 999 1000 468 3550 3939 1956 2932 1499 PMC11274826__F6 Osteopontin: A Key Multifaceted Regulator in Tumor Progression and Immunomodulation 2191 9332 4345 8205 1000 79923 4283 PMC11275360__F3 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation 324 1499 1857 283120 PMC11275360__F5 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation 6714 4342 861 PMC11275360__F6 Function and Mechanism of Long Noncoding RNAs in Adipogenic Differentiation 5163 100874345 2309 2475 PMC11275499__F1 Antidepressant potential of ghrelin, which exerts neuroprotective effects by promoting neuronal proliferation and neurotrophic factor production in the brain 3717 6774 2475 1499 627 PMC11276060__F3 LncRNAs in autophagy, apoptosis response, and inflammation of cells to bacterial invasion 4049 2146 6775 2475 55384 4615 7503 114548 PMC11276987__F2 Schema of pathways producing and utilizing endoplasmic reticulum (ER)-derived H2O2 50507 10549 493869 PMC11276987__F3 Maladaptive UPR and endoplasmic reticulum (ER) stress-mediated inflammation 5212 468 83939 22926 7494 7186 7124 PMC11276987__F5 Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review 3569 114548 23411 3297 2475 PMC11276987__F7 Adiponectin signal transduction [118] 51094 79602 26060 5728 PMC11276987__F10 Lipids as signaling molecules that regulate metabolism 7099 6714 4615 3667 10454 3661 PMC11277110__F2 Roles of miRNAs involved in the developmental growth and apoptosis of Drosophila 5163 7249 7248 6009 6497 406904 PMC11277110__F4 Signaling pathways regulated by miRNAs in wing development 51684 6608 474168 324 79971 PMC11277296__F2 Mechanisms of mitochondrial dysfunction 581 56947 55669 9927 4976 51024 637 8717 8772 2021 27429 115004 114548 29110 3661 PMC11278003__F5 KEGGs pathway and GO molecular function (MF) analysis based on AD correlated interactors of Apaf-1 and TNFA 7124 3569 3553 7099 2597 1401 3630 920 3586 PMC11278107__F3 Antifibrotic activity of EchA in SSc model 6362 4088 968 9332 4843 7097 PMC11279058__F2 Mycoplasma hyopneumoniae generates immune evasion by modulating the host immune system 7097 7099 10333 22926 7494 3553 7124 581 PMC11279438__F1 Vitamin D’s role in skeletal muscle 1628 4036 8029 7421 2309 PMC11279438__F2 Relationship between oxidative stress and weakness of muscle 7124 23411 6647 6648 PMC11279438__F3 Antioxidative role of vitamin D in muscle dysfunction 9817 23411 2309 9927 55669 4976 PMC11280061__F6 Auxin-regulated TFRN attenuates lignin biosynthesis 23261 50805 729230 PMC11280205__F5 Mechanism in the development of a higher 2D:4D ratio 367 4854 4087 4088 8877 PMC11280308__F3 Mechanisms of action of the A 8772 8717 998 581 331 317 3596 1385 6778 6774 6772 6773 3662 941 7124 1019 983 1017 2475 4087 4088 4089 999 1000 PMC11281156__F6 Proposed cellular signal transduction pathway of TCBPA-induced cell inflammation in Jurkat cells 2852 3569 7124 2876 3605 6647 5597 5599 2938 847 3558 3552 5594 6648 5595 PMC11281541__F10 Hypothetical schema of the protective role of MIN in TBEV-infected Vero cells 6616 1956 6262 23208 PMC11281550__F6 Changes in metabolites in PI3K/AKT/FOXO signaling pathway after TeA, PAT alone, and combined exposure 4089 4088 51701 6502 4193 6418 664 9140 3630 3643 5728 23411 472 6774 1956 8213 1017 10365 PMC11284386__F1 Systemic and renal iron homeostasis 6774 151176 3091 2056 PMC11292300__F4 The rationale for possible targeted therapies in CMTC 8312 324 5728 64840 2475 5979 673 4609 595 6774 2002 2353 PMC11294417__F10 Schematic diagram for NEK2 functions during porcine embryonic development 4751 1499 4041 4040 324 4609 1017 983 891 995 11200 1111 4361 5591 672 2547 PMC11294427__F2 S100A9 binds to Toll‐like receptor 4 (TLR4) to activate downstream pathways for biological effects 7099 6280 4615 114548 6010 5879 5880 5465 PMC11302868__F2 Four main defense pathways in ferroptosis 2643 1723 2879 PMC11302957__F1 Core components of the Hippo pathway in mammals 10413 4485 60485 9113 558 374 81788 PMC11302957__F3 Crosstalk of Hippo signal pathway with other signaling pathways to regulate YAP1 2535 11235 1956 3082 340419 5959 4485 60485 5163 9113 2475 10413 51804 PMC11307883__F3 Metabolic pathways of the microRNAs and their target genes 7915 56954 2746 18 2571 9945 2752 27165 5471 8659 790 1373 1029 1019 1021 1030 595 1869 4149 6500 6502 1017 898 5925 1441 3569 PMC11310285__F2 Hypoxia pathway proteins-microRNA-phosphodiesterase crosstalk in steroidogenesis regulation 3091 8622 5138 6770 1583 1586 1584 3291 3290 PMC11311281__F4 PAR2-induced Beta-catenin stabilization and targets of RNF43 1499 54894 5728 5163 PMC11311379__F9 Regulatory effects of novel-m0230-3p on cell TJs and adhesion via CSF1/CSF1R/Ras signaling pathway in yak SCs 1435 1436 999 PMC11311579__F1 Metabolic pathway of vitamin D and the role of VDR (Vitamin D Receptor) in signaling based on Płomiński et al 1717 1583 1593 120227 7421 PMC11312265__F1 Molecular mechanisms of inhibited and activated canonical Wnt/Beta-catenin signaling pathway 4041 4040 1499 324 100420631 PMC11312265__F2 Signaling cascade of non-canonical Wnt/PCP and Wnt/Ca2+ pathway 4920 4919 6259 5754 23002 6010 5879 998 51701 1499 PMC11312265__F5 Non-canonical Wnt/PCP and Wnt Ca2+ signaling and their implications in cancer 57216 81839 846 960 6010 51701 PMC11312279__F9 Ceramide Ehux-C22 Targets the miR-199a-3p/mTOR Signaling Pathway to Regulate Melanosomal Autophagy in Mouse B16 Cells 2475 8408 4157 9474 PMC11312684__F2 GPx4 in the ferroptosis regulatory pathway: (a) GPx4 catalytic cycle representation 6520 23657 3156 4015 3652 PMC11312688__F2 Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention 59272 6868 9817 23411 PMC11312688__F3 Proposed Rearticulation of the Mechanism for Radiation-Induced Fibrosis: Initial radiation exposure initiates at least three distinct pathways 6741 90865 3458 50508 27035 50507 79400 50506 53905 PMC11312736__F8 Saturated and unsaturated fatty acid metabolic pathways and mevalonate and isoprenoid biosynthesis at intermediate and mature stages of YGD and MPT zygotic embryos 27349 39 3156 4597 3422 1891 PMC11314049__F5 Schematic illustration of reactive oxygen species (ROS)-mediated activation of various cell signaling pathways in the skin 6722 1386 596 PMC11314475__F5 Investigating the Molecular Mechanisms of Resveratrol in Treating Cardiometabolic Multimorbidity: A Network Pharmacology and Bioinformatics Approach with Molecular Docking Validation 3757 8942 411 2162 3002 7349 7124 10133 9611 3351 10763 2878 1675 3736 5644 5984 2934 10855 5284 50506 374 100 2252 1401 1432 1910 6855 8972 1363 8835 2057 3065 1717 7295 7056 3385 5599 3164 132 26291 114757 5394 84811 4060 7067 1491 3667 7402 4277 7431 6943 6775 375790 4282 8877 644 3240 3075 5962 352909 1605 1719 6932 6582 4023 56616 2947 7015 23266 183 6717 3188 5196 10468 7068 3745 799 5697 1191 80724 3984 4670 7066 1956 50507 5600 7414 4217 158 652 10135 5376 655 1756 6941 2937 4353 6010 5046 7086 63826 3162 1674 8458 875 7450 3263 6801 10411 3708 27035 953 56652 6876 9021 2944 3952 4656 2249 5538 5598 8823 4214 5337 348 1520 4860 2010 10529 3192 64131 1806 7389 367 4864 255738 2597 92667 1952 115004 2257 56729 3630 5594 50508 3423 2255 3728 3082 7173 762 1103 93649 4683 5241 79172 633 2052 706 1803 6774 26960 6722 55937 100506658 1513 4151 2251 5021 5340 5982 3659 5972 8504 2690 6414 10577 6560 2006 6885 7423 5530 3831 2028 9734 2877 3248 2538 54875 1621 2332 7038 813 302 4842 84233 3161 2876 3981 128674 4659 196 2194 148113 213 6580 64409 1893 326 4256 191 2260 8074 51259 3458 7019 4072 811 53905 3953 10280 100507436 5111 8841 3709 7035 4899 57105 26762 6262 718 8542 309 8651 650 10499 2968 8660 2520 2670 1509 885 9365 727 2056 10654 959 5230 3710 4691 27302 8862 3036 3066 3383 949 5617 1361 7424 11343 567 8648 847 30061 5914 405 9536 2643 7276 826 3178 301 2246 PMC11338244__F2 Tamoxifen resistance 2475 5728 5163 3845 7248 7249 6009 PMC11338244__F4 Methylation of the PI3K/AKT/mTOR signaling pathway on tamoxifen 3845 5728 205 56339 5163 467 6297 9518 7248 7249 285489 5308 6009 54206 283576 283120 2146 PMC11347096__F2 Phospholipids and their binding proteins mediate normal or malignant B cell activation 5728 613 930 695 6850 6714 84433 8915 10892 PMC11347096__F5 Schematic diagram summarizes the regulation of lipid metabolism in normal or malignant B cells 695 613 8877 56848 7357 4609 5728 2194 6714 84433 4615 PMC11347096__F6 Schematic diagram summarizes the potential therapeutic targets of different lipid species and related pathways to treat inflammatory disease or B cell malignancy 613 8877 56848 355 7357 695 2475 4609 3065 3066 PMC11350665__F7 Main biological pathway responses to acute Cd exposure in oysters 914 10257 8714 5243 19 2194 4259 51056 4553 PMC11350703__F18 PDK1-mediated TGFB/Smad signaling pathway by hypoxia in yellow cattle and yak PASMCs 5163 8877 4087 4088 PMC11351389__F2 Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review 860 121340 632 8074 7077 PMC11351389__F3 Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review 2932 8313 4041 4040 1499 9242 PMC11351392__F3 Targeting the Nrf2/HO-1 axis for the treatment of IBD 114548 999 2879 PMC11351628__F1 PPAR targets and contributing factors in MASLD/MASH 116255 7038 9370 2167 948 4547 348 344 4023 345 84649 376497 3158 1962 7942 355 5465 PMC11351691__F4 Hub proteins were obtained and verified by molecular docking 1956 100187761 2159 9429 23476 10135 3620 5315 1268 196 5027 5742 1559 7099 1387 3791 673 5290 PMC11351910__F3 PI3K/AKT signaling pathway and miRNAs in pancreatic cancer 1950 1956 4585 7157 406942 5728 5163 2475 406991 407006 PMC11351910__F4 KRAS signaling pathway and miRNAs in pancreatic cancer 1950 1956 2885 10253 406935 407053 PMC11351910__F5 JAK/STAT signaling pathway and miRNAs in pancreatic cancer 2056 4843 9111 4609 9306 PMC11351910__F6 TGFB signaling pathway and miRNAs in pancreatic cancer 64750 4089 4087 PMC11351910__F7 Wnt/Beta-Catenin signaling pathway and miRNAs in pancreatic cancer 407010 4041 4040 54623 324 2932 1499 4609 PMC11352684__F4 TRIM proteins in the cellular signaling pathway of MAFLD 29886 8805 7726 6737 2194 10626 81603 79931 201292 23118 257397 10475 64285 2879 286827 11074 1052 3091 23411 440730 PMC11353125__F1 Receptor tyrosine kinases (RTKs), epidermal growth factor receptor (EGFR), and its variant EGFRvIII activate the PI3K/AKT signaling pathway, subsequently influencing mTOR activity 1956 5728 253260 5163 5164 8408 PMC11353167__F1 FCERI signaling pathway 27040 4067 6850 2534 2885 9846 8915 10892 PMC11353167__F2 MAPK signaling pathway 6010 998 5879 2002 26959 1386 3727 3726 PMC11353192__F7 Lactate and LOX regulation of the HCAR1-RAS/PI3K signaling cascades 7018 27198 6654 2885 2549 4015 PMC11354414__F3 Cell signaling pathway involving TNFA in activating NFKB 7124 8737 29110 10454 23118 PMC11354507__F1 SARS-CoV-2 entry, mitochondrial damage sensing and innate immune dysregulation 79065 59272 7113 65018 57506 3661 29110 7187 115004 54106 114548 PMC11354507__F2 Inflammation triggered by macrophage after SARS-CoV-2 infection 59272 7096 7097 7100 10333 7113 3716 7297 3717 6772 6773 6774 57506 51284 115004 54106 4615 7187 10379 7189 29110 3569 PMC11354614__F2 Glucose and stress metabolism 178 2997 5837 5236 2821 5213 226 2597 7167 5230 5224 2023 2027 5315 3939 3945 3312 3315 126393 3326 10935 25824 765 761 771 768 767 762 56934 377677 766 770 23632 1410 3336 493829 309 310 312 311 653145 11199 8416 6647 6648 11315 2739 1652 2876 4357 23530 8078 23066 PMC11354764__F1 Insulin signaling pathway 2885 3667 867 1398 7249 572 6009 PMC11354818__F12 Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice 10006 10152 7018 64641 1879 51411 PMC11355432__F7 Proposed model for the protective mechanism of CPE against CKD-induced HAS 1363 59272 1628 5091 PMC11356322__F3 Metabolic pathway interaction network of Cluster-0 metabolite (4-hydroxybenzoic acid) 51004 57017 84274 23590 57107 6713 8564 27235 6817 PMC11356641__F4 Signaling pathway involved in probiotics recognition 7097 7096 10333 4615 114609 51135 3654 3656 7189 23118 10454 PMC11356869__F1 Signaling pathways in osteogenesis and osteoclastogenesis 1513 4772 100187907 7189 860 650 4086 4090 4089 1499 PMC11356869__F2 East Asian Herbal Medicine (EAHM) effect on bone to prevent osteoporosis 4615 3654 7189 1499 650 860 4513 4314 PMC11356883__F4 Outline of the DTSAs biosynthetic pathway in Dendrobium species 252843 587 124512 PMC11356930__F3 MEHTCMPs on the MAPK signaling pathway 2885 4615 3654 51135 7189 5894 3929 6772 6774 PMC11356930__F5 MEHTCMPs on intestinal flora 7099 4615 7124 PMC11357136__F2 Several modulator molecules linked to the signaling of GLP-1 receptor within the PI3K/AKT/mTOR pathway are demonstrated 4803 5163 5728 253260 8408 PMC11357158__F1 Biological pathways and interactions of three ncRNAs 54487 1243 828 29102 10482 PMC11357158__F3 Hippo and Hedgehog pathways mediated by identified ncRNAs 5727 55384 60485 4485 51684 374654 55294 9113 55233 7004 7005 7003 8463 6608 156 283131 PMC11357158__F5 Wnt/Beta-catenin pathway and associated ncRNAs 84973 4041 4040 114004396 324 283131 PMC11357207__F4 Working model to propose ABC-transporter mediated cholesterol efflux reduces the pro-inflammatory immune response that initially occurs from T 7099 19 9619 PMC11357267__F3 Pathways altered in chickens vaccinated with GII 22937 22926 7186 83939 7494 468 10682 811 821 596 267 6400 10956 7415 PMC11357512__F2 Signalling pathway in a cardiomyocyte with lamin A/C variant factors such as pERK1/2, pSmad1/2, and TEAD1 affect the gene expression of LMNA mutant cells 5159 7003 817 59341 6262 PMC11359136__F2 HCMV regulates the classical Wnt/Beta-catenin signaling pathway 4041 4040 324 1499 PMC11359136__F3 HCMV regulates the Notch signaling pathway 102 110740339 6774 23462 23493 182 6657 PMC11360076__F4 Protein–protein interaction map of the upstream regulators that significantly altered after the exposure to V 1081 5617 102 135 84231 4430 1641 5329 7317 8450 9589 23367 2332 5997 2521 23532 58485 26097 3070 55746 57333 57634 5888 4613 1594 3064 5728 6794 4893 5607 2353 5295 7786 130367 124976 8192 22937 80781 224 3172 217 463 51085 2936 405 6415 7494 6515 54502 915 9915 6775 26119 3600 468 2938 6402 23321 7350 3298 6048 58495 706 7174 PMC11360101__F7 Cytoscape shows the interactions between 9 major components of CSAEs and 4 known kidney injury pathways 5350 6786 7222 57620 1610 6262 84876 7098 8737 8717 11035 7186 7099 4958 2475 998 5879 8772 6093 387 PMC11360101__F13 Actin Dysregulation Mediates Nephrotoxicity of Cassiae Semen Aqueous Extracts 387 5879 998 PMC10093079__F7 Baicalein inhibits cancer cell progression by targeting P13K/FOXO pathways 2475 5728 581 PMC10093344__F1 Innate immune signaling pathway that recognizes cytosolic DNA in tumor-infiltrating dendritic cells (TIDCs) 115004 9447 834 3661 79792 7124 PMC10093344__F3 Tumor immunosuppressive mechanism of AIM2 in TIDCs 115004 9447 29110 3661 3606 79792 3627 PMC10094755__F6 Metabolic pathway of 17Beta-estradiol biosynthesis 6770 1583 3294 3284 3283 6715 3292 1588 PMC10095465__F1 Apoptotic signaling pathway 4170 572 637 7124 355 8717 8772 581 90427 8739 331 PMC10121353__F8 Main nodes of AGE-RAGE signaling pathway 183 5091 574 4162 351 PMC10125773__F3 IL-1A and IL-1B synthesis and signal transduction pathways 7850 4615 3654 7189 PMC10135819__F2 Diagram illustrating RET and RET-regulated NAD+-dependent sirtuin signaling pathway as a contributor and potential therapeutic target for aging, age-related diseases, and ischemic stroke 4722 5979 4723 PMC10136030__F2 Classification of BCL-2 family proteins and their role in the regulation of the internal pathway of apoptosis 581 572 638 90427 8739 666 PMC10136030__F4 In the nucleus, TERT performs both canonical (elongates telomeric ends) and non-canonical functions (participates in the regulation of gene expression) 7015 545 472 581 637 2021 595 331 PMC10136628__F1 Metabolic pathway of tetrahydrobiopterin (BH4) 1719 7054 5053 PMC10137236__F1 TGFB signaling pathway 4089 4092 4087 4088 7046 PMC10137309__F3 Extravasation steps in lung cancer brain metastasis 214 57016 6347 8754 84879 6010 PMC10137494__F2 Steroid synthesis pathway 1589 1584 1585 PMC10138520__F2 Compounds secreted by adipocytes support tumor growth, angiogenesis and metastasis 6774 3479 3082 7422 4320 PMC10138595__F3 PGE2 Promotes Immunoregulation through Cross-Regulation between Beta-catenin and NFKB by Activating the Wnt-Beta-catenin Signaling Pathways 324 2932 1499 PMC10138623__F6 TLR4–RAGE crosstalk participates in the HG-enhanced LPS-induced inflammation in BAMs (created with BioRender 7099 3146 6279 4615 PMC10139027__F5 Scheme of LDLR activity signaling pathway for follicular development with lovastatin stimulates steroidogenesis in ovaries 2492 6770 3949 PMC10141515__F6 Differentially expressed proteins of the serine metabolic pathway in ovarian cancer 5723 6472 29968 26227 PMC10142234__F1 Graphical representation of JAK-STAT signaling pathway and therapeutic compounds suppressing it through the inhibition of one or several members of the family 3716 7297 3717 3718 PMC10143138__F2 Osteoblast cellular cholesterol homeostasis 3949 7038 3156 PMC10143509__F3 Involvement of p53 in activation of interferon genes, of interferon-stimulated genes, and in feedback loops regulating these processes 3716 6772 7297 6773 27293 3635 57506 3437 115004 3661 3665 152007 3663 3717 8651 10379 64135 4599 9636 3433 3434 84875 PMC10144233__F2 Formation of uroporphyrinogen III (UPG III) and the branching of the heme b biosynthesis 1362 3145 7390 7389 56961 PMC10145673__F1 G-protein-coupled receptor (GPCR) signaling pathway 6714 1956 9049 2475 196 405 PMC10147314__F2 NEDD8 regulates the ubiquitin-proteasome degradation pathways related to CRL and MDM2, and it realizes the regulation of proteins by promoting the NFKB, PI3K/AKT/mTOR, Hippo-YAP and receptor tyrosine kinase signaling pathways 2475 4193 1956 4738 5728 7428 PMC10147314__F3 Several signaling pathways are closely related to NEDD8 4193 5728 2475 5479 PMC10147314__F5 NAE inhibitor MLN4924 has utility in the treatment of lung cancer 4295 140739 2475 PMC10158029__F12 The regulator mechanism of S100A16 in Glioma 140576 4485 9113 8451 PMC10173380__F7 Schematic diagram illustrating the mechanisms through which VNN1 in PC cells induces Beta-cell dedifferentiation by inhibiting the AMPK/GAPDH/Sirt1/FoxO1 signaling pathway 8876 23411 2597 2308 PMC10177097__F9 Effects induced by Exe plus CBD in MCF-7aro cells 367 1960 374 7031 PMC10177541__F9 Effects and mechanisms of SQSTM1/p62 on migration and invasion of HCC 9817 4313 4318 PMC10178416__F2 Schematic drawing presenting signaling pathways affected by ferulic acid 7099 9817 581 7040 4087 4088 4092 4089 PMC10178434__F2 D+ synthesis pathways 93100 349565 64802 23057 10135 PMC10178469__F2 Downstream signaling pathway of TLRs 7099 4118 4615 51311 51284 7098 54106 PMC10179314__F1 PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis 3082 1950 1956 7428 2475 PMC10179536__F9 Proposed diagram for the therapeutic effect of PRP improved bladder overactivity induced by OHD in rat model 960 6662 2475 PMC10179672__F4 Ligands, receptors, and transcriptional regulators of Hedgehog signaling pathway 6608 51684 2736 2735 PMC10180667__F5 Effect of FS on toll-like receiver signaling pathway 7097 5879 10333 54472 4615 8772 114609 3929 929 23118 7189 958 3663 942 3661 51135 3665 1513 54106 7098 7187 PMC10181252__F1 Wnt/Beta-catenin signaling pathway in tumor progression 324 2932 1499 PMC10181252__F2 Various flavonoids on the Wnt/Beta-catenin pathway 2932 324 1499 PMC10189745__F1 IL-36 signaling pathway 27179 4615 7189 PMC10193374__F1 In wound healing, CTHRC1 can recruit additional M2 macrophages to the wound site to promote skin repair and activate the TGFB and Notch pathways 115908 4851 4855 2931 324 5879 2885 387 1798 6093 9475 23462 23493 3280 388585 6850 2475 PMC10197881__F9 Proposed mechanisms 729230 6772 6624 55008 54739 PMC10198710__F2 m6A methylases that participate in cancer glycolytic metabolic pathways 5166 56339 57721 2026 3099 9589 2186 54890 79068 54915 PMC10203752__F3 Mechanisms of proanthocyanidins in treatment of HSP 4615 7099 7124 PMC10215119__F1 Mechanisms involved in the regulation of macrophage polarization by exosomal ncRNA in AS 9619 19 652 6774 8091 9314 10642 5728 1316 PMC10215262__F2 Studies related to the role of the Wnt/Beta-catenin signaling pathway in Acute Myeloid Leukemia 7471 7482 2305 7480 22943 864 8322 64321 11197 4297 PMC10215516__F2 PI3K/AKT/mTOR signaling pathway activation in HPV-positive HNCs 5728 6590 2475 PMC10215719__F7 Proposed mechanisms of the effect of Ptn overexpression (A) and the pharmacological inhibition of RPTPB/ζ with MY10 (B) on some of the principal signaling pathways implicated in ethanol and/or LPS acute response in adolescent mice 5764 7099 238 2534 PMC10215824__F3 Obesity-altered adiponiche and tumour development: some novel proposed mechanisms in mature adipocytes and precursor cells 7124 2475 7018 7424 947 PMC10215861__F3 Roles of RONSs during skeletal muscle pathologies 3479 260431 1756 3667 847 2475 8408 PMC10216084__F8 TRPV4 and TRPM8 signalling pathways relevant to the present study 59341 79054 729 7225 7222 PMC10216109__F2 Melatonin antioxidant properties and tryptophan metabolic pathway 847 57716 438 1312 23066 PMC10216286__F1 The TRAIL apoptosis pathway 8772 637 581 PMC10216337__F6 Schematic representing the suspected roles of and molecular pathways involving MeCP2 in prostate-cancer progression 4204 7077 8805 1647 PMC10216404__F4 Effects of RSV on the regulation of microRNAs and BMP2 signalling in protecting bone 650 50507 860 9242 PMC10216531__F1 The fundamental parts of TLR4 signaling 3929 7099 929 114609 4615 7189 29110 11035 7187 3661 PMC10216727__F3 Proposed mechanism of vagus-mediated liver regeneration 6774 3569 2305 PMC10216727__F6 EGFR/mTOR signaling pathways that regulate FOXM1 are involved in Beta-cell proliferation 1956 2475 2305 PMC10216802__F2 LPS (TLR4)-mediated inflammation and its interplay with RhoA activation and the downstream ROCK signaling pathways 7099 7124 387 6093 9475 PMC10217757__F1 Specific Features of Focal Cortical Dysplasia in Tuberous Sclerosis Complex 7248 7249 51256 6009 57521 64798 2475 84335 PMC10218028__F2 SNPs affecting NET formation 6850 55083 4353 7128 84000 PMC10221877__F8 Response of DA metabolic pathway to Cd stress in duckweed 7054 1621 5409 PMC10222038__F1 Vitamin D metabolic pathway 120227 1594 5891 PMC10222229__F2 Roles of protein phosphatases in liver regeneration 6774 5494 5208 PMC10236263__F6 Models of the positive regulatory feedback loop of p65/miR-27a-3p/TAB3/NFKB axis 7187 9020 257397 PMC10242764__F5 Construction of drug-compound-target-pathway network 718 727 735 717 729 730 PMC10251820__F1 Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis 1956 2885 5728 2475 4193 572 PMC10252624__F1 Mechanisms of VEGF (receptor) inhibitors-induced cardiovascular complications 7422 7423 7424 PMC10253306__F2 Interactions found in polyQ-containing ID hub proteins located in both cytoplasm and nucleus using protein interaction annotation of HPRD 7874 8841 6310 PMC10253447__F1 Notch signaling pathway inhibition leads to intestinal differentiation 28514 3516 474 3280 4583 PMC10253447__F2 Hedgehog signaling pathway in the development of intestinal metaplasia in the distal esophagus 4089 50846 3549 652 6469 6608 5727 8643 4086 4090 4583 1045 10551 3170 6662 51684 PMC10253478__F1 Action of probiotics 627 1325 2638 727897 4583 4588 56667 4582 4585 94025 81793 7097 50943 3565 3558 PMC10255413__F2 Biosynthetic pathway of chlorophyll 1371 5498 4256 5447 PMC10255599__F3 Anti-oxidant and anti-thrombotic activity of Vitamin D and Resveratrol in COVID-19 462 7421 114548 3146 PMC10258460__F1 Novel Metabolic Detour for Pancreatic Cancer Survival 4942 1316 6723 6611 3845 PMC10266770__F1 STAT2 deficiency and other inborn and acquired defects of type I IFN signaling result in susceptibility to viral infections 3716 7297 6772 6773 PMC10281733__F10 LPS-antagonist potential of Q3G on pulmonary injury 114548 7099 581 79792 PMC10286592__F1 How TBI altered calcium dependent PLC pathways, oxygen species scavenging system and p53 signalling 3146 4615 8195 PMC10286596__F1 Mitochondrial biogenesis in neurons 23411 219402 4528 5442 64216 5428 7019 4899 51106 PMC10286596__F2 Resveratrol-modulated mitochondrial biogenesis in neurodegenerative diseases 10135 23411 2309 2308 7015 23409 7019 PMC10296091__F1 A2AR effects in microglia, astrocytes, and synapses under physiological conditions 84890 367 627 PMC10296498__F1 IL-33/ST2 signaling pathway activation 90865 4615 23118 54472 7189 PMC10296705__F2 Biosynthesis pathways of isoprenoids and the biosensors that are responsive to isoprenoids and their precursors 7275 727 3652 PMC10296711__F5 Schematic illustration of the activation process of TLR receptors and their downstream signaling molecules upon activation forming the TLR-MYD88-IRAK1/4-TRAF6-NFKB/IRF or TLR3/TLR4-TRIF-IRF/NFKB signaling pathways 4049 10333 7097 7100 7099 81793 4615 51284 51311 3654 51135 54106 7098 7189 7124 3569 6347 942 941 7096 PMC10296711__F12 Schematic illustration of the IL1-R/TLR/NFKB pathway with emphasis on activation of different NFKB subunits via the IRAK1/TRAF6-mediated pathway 4615 3654 51135 11213 3656 7189 23118 257397 PMC10297006__F2 Ezrin controls several major cellular functions through the regulation of downstream signaling transduction pathways 6010 6495 6667 PMC10297110__F5 The effects of inhibiting TGFB signaling pathways on hCECs in vitro 4087 4088 6010 2475 11319 PMC10298365__F5 Neonatal Meningitis-Causing Escherichia coli Induces Microglia Activation which Acts as a Double-Edged Sword in Bacterial Meningitis 3569 3553 7124 PMC10298409__F11 Integrated Transcriptomics and Metabolomics Analysis of the Fructan Metabolism Response to Low-Temperature Stress in Garlic 2821 7360 2582 2717 PMC10298860__F11 Albino phenotype of ‘HJY’ might be modulated by a plastid retrograde signaling pathway 5447 27159 79717 PMC10299133__F1 HGF/MET signaling pathway and most frequent alterations in NSCLC 3082 6774 3845 PMC10299161__F4 Oxidative stress promotes the activation of programmed cell death initiated by intrinsic apoptotic signaling in the mitochondria or extrinsic apoptotic signaling by death receptor pathways in CRC cells 637 572 581 PMC10299206__F2 TGFB signaling pathway 4087 4088 9618 6010 4092 4091 4089 2475 3725 29102 PMC10299455__F2 NOTCH signaling pathway, ligands, and inhibitors 3516 4609 3280 100188776 4067 2534 640 PMC10299596__F1 BCR signaling pathway and BTKis resistance in CLL 6714 613 4067 6850 695 29760 5336 2475 PMC10299676__F1 Mechanisms for activation of the JAK-STAT signaling pathway 3716 3718 3717 7297 PMC10300995__F3 Altered fatty acid metabolism and potential drugs in DLBCL 5728 948 2194 2475 47 PMC10301361__F4 Involvement of the cytoskeleton in the immune response to viral infections 57506 29110 3661 PMC10302777__F2 Betaine as a Functional Ingredient: Metabolism, Health-Promoting Attributes, Food Sources, Applications and Analysis Methods 875 4524 635 4397 PMC10304117__F1 ASFV proteins modulating the cGAS/STING and NFKB signaling pathway (Created with BioRender 10379 51444 115004 79589 3661 29110 PMC10304648__F1 Detection of influenza A virus infection by pattern recognition receptors (PRRs) and NLRP3 inflammasome 51284 114548 7098 3665 3240 3661 23586 57506 PMC10304713__F2 SARS-CoV-2 employs different mechanisms to activate the host’s innate immune system 4615 3654 51135 7189 23118 5966 7706 10379 57506 3661 PMC10312956__F3 Networks of the rare-variant genes associated with suicidal behaviors in AI 64344 1639 2697 5179 4985 3293 405 7423 3791 5176 3087 6402 2321 947 10371 8829 6770 80765 90075 200010 PMC10316197__F2 Inflammation on NAFLD progression 6774 7099 7124 3667 7128 54106 PMC10316197__F3 Apoptosis in NAFLD patient 6431 3661 581 6041 11232 4833 6035 PMC10334824__F5 Prospective application of lncRNAs in the treatment of diabetic wounds 378938 283120 2146 6662 5728 5629 114548 100124700 PMC10336275__F3 CREB-induced immune response 51135 4615 7189 5970 7124 PMC10340243__F5 The main metabolic pathways of unsaturated fatty acids 4015 239 242 1103 PMC10340761__F4 Gene interaction pathways and their regulation in cancer 768 112399 79365 56901 PMC10341168__F9 Ginsenoside Rh4 Improves Hepatic Lipid Metabolism and Inflammation in a Model of NAFLD by Targeting the Gut Liver Axis and Modulating the FXR Signaling Pathway 1582 2194 7038 PMC10341567__F3 Major pathways and interactions regulated by GSK3B: (A) Wnt/B-catenin pathway and (B)PI3K/Akt/mTor pathway 1499 2932 324 2475 PMC10341567__F4 Major pathways and interactions regulated by BACE1: (A) Notch signaling pathway, (B) Amyloidogenic pathway, and (C) NFKB pathway 4851 23621 182 2932 PMC10341567__F5 Major signaling pathways that regulate SREBP2 activation during cholesterol synthesis: (A) P53 pathway, and (B) Akt pathway 387 19 7249 6009 2932 PMC10341567__F6 Major pathways in which ABCA1 plays an important role for cholesterol transport in brains: (A) Reverse cholesterol transport pathway, (B) LXR/RXR pathway, and (C) SREBP2 pathway 19 335 3931 949 948 22937 PMC10341567__F7 TREM2/DAP12 pathway 348 54209 6850 2932 1499 PMC10341762__F1 One-carbon metabolism 1719 4552 4397 635 4524 4522 572 875 PMC10341911__F3 Syntenic analysis of genes in the Moso bamboo and rice cytokinin pathway families 3240 100188821 100286836 PMC10341937__F2 Canonical Wnt signal transduction pathway 4041 4040 2932 324 PMC10341994__F8 Mechanism of AM polarization toward M1 phenotype and early apoptosis induced by rLLB exposure 3569 581 596 PMC10342868__F8 Regulatory mechanism of lncRNA 220 7099 4615 5290 5295 2475 PMC10343400__F6 Glycosides and UC-related receptors AND transcriptional regulation 7099 114548 1728 PMC10343815__F5 Differentially expressed genes in the cAMP metabolic pathway suggested that upregulated genes were dominant in this pathway 7432 2695 6750 4852 5020 51738 1080 268 572 PMC10343931__F4 Possible mechanisms by which exercise upregulates NAD+ to improve mitochondrial autophagy 25886 23057 23411 92014 PMC10346897__F4 Mechanism by which PUFAs suppress cholesterol synthesis via inhibition of the signaling pathway of sterol regulatory element-binding protein-1 (SREBP-1) [74] 107966124 355 9619 64240 64241 3638 22937 PMC10367551__F8 Mechanism by which miR-552-3p alleviates liver fibrosis and inflammation 7046 4087 4088 7048 4089 6347 39 1277 1281 7077 PMC10369979__F1 An oligonucleotide-based cGAS agonist for cancer immunotherapy 115004 594857 3661 PMC10373120__F5 Regulatory pathway involving lncRNA H19, miR-124-3p and ITGB3 in modulating ectopic endometrial cell proliferation and invasion in endometriosis 283120 3690 59 PMC10376127__F1 Coenzyme Q functions 55349 1723 717 5625 718 2110 29958 1757 1728 PMC10377024__F4 Landscape of Genetic Mutations in Appendiceal Cancers 1956 7039 1950 2322 3082 PMC10377024__F6 Landscape of Genetic Mutations in Appendiceal Cancers 5290 5728 1956 1950 2064 2322 3082 PMC10379333__F3 Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots 19 6347 2475 7249 PMC10380638__F5 Schematic presentation of low-dose IR-induced immune effects in the spleen of mice, according to Cho et al 920 4280 3567 PMC10381003__F2 The TLR signalling pathways with highlighted gene polymorphisms involved in OA susceptibility 54106 51284 51311 7097 7096 10333 7100 7099 4615 7098 7187 7189 3661 PMC10381408__F3 Compound K Production: Achievements and Perspectives 369 152100 5925 2147 PMC10383295__F2 High levels of ROS promote cancer cell growth, proliferation, invasion, and metastasis 847 5209 6741 PMC10384352__F2 Review: Understanding Molecular Mechanisms of Antibody-Dependent Enhancement in Viral Infections 715 716 721 PMC10385272__F5 Key gene expression patterns in carbohydrate metabolism and lipid metabolism pathways in the pulp and seeds of Symplocos paniculate 2821 2632 4018 47 2271 4967 PMC10385528__F3 Anticancer mode of action of melittin on the essential molecular targets in different carcinomas 581 595 6774 4313 PMC10385841__F5 Top networks associated with lipid metabolism identified in PIEs infected with G9P[13] 91057 132299 127391 27163 5090 2117 85439 27141 133 1677 158763 79853 79026 219738 2588 11218 50636 1201 79152 8707 9766 PMC10385954__F13 Putative mechanism of artemisinin neuroprotective action against 6-OHDA and MPP+-induced neuronal injury 2885 2534 6714 PMC10413047__F2 LncRNAs regulating the proliferation and apoptosis of NSCLC 101929074 4904 378938 1832 6015 7503 100506392 4194 PMC10413047__F3 CASC9 and lncRNA UCA1 in drug resistance in NSCLC 101805492 652995 2355 2146 1843 PMC10417115__F2 miRNA binding sites at the rs8720 and rs12587 variants of the KRAS gene and their function in tumor regulation 3845 5728 6667 PMC10417677__F3 Anti-inflammatory mechanism of MBPs 7124 114548 3569 PMC10418475__F1 Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects 4157 1638 4286 PMC10418722__F12 Study on the Regulation Mechanism of Quality Deterioration Due to Chilling Stress and Dry Exposure during Anhydrous Storage and Transportation of Yesso Scallop Patinopecten yessoensis 351 3725 4975 PMC10418793__F6 Major pathways involved in retinal inflammation 6774 5971 3725 2353 2475 PMC10418941__F2 Molecular crosslinks produced by the interaction of the HSCs and LSCs 1000 3491 9314 79923 PMC10418941__F3 LSCs’ microenvironment in relation to epigenetic modification 10664 834 5788 968 7099 51284 7124 7422 3569 960 4609 3914 860 406984 406983 5728 554210 PMC10419312__F3 Agents to target macrophages in CTD-ILD 90865 6761 4088 4089 4092 1499 6275 PMC10419760__F1 TLR2 MyD88-dependent signaling pathway 7097 114609 4615 3654 51135 7189 23118 257397 PMC10420321__F8 Molecular mechanism underlying the beneficial effects of FJE in the OVA-induced CARAS mouse model 90865 6761 85480 PMC10439834__F1 IL-17 signaling pathway: transduction and amplification 9618 7188 7186 10682 PMC10443056__F1 Different interventions enhance nerve regeneration for the treatment of AD 627 4803 43 9242 PMC10447124__F8 Mapping of Rap1 signaling pathway in NI vs 22808 2778 2776 1398 60 3713 6714 27040 847 147111 64840 4301 387 27130 3265 5467 PMC10451182__F2 Intrinsic and extrinsic apoptotic pathways and confirmed target genes of miR-106a 355 11124 8772 7124 5728 637 581 PMC10451275__F3 Changes in subcellular localization of Ras upon S-nitrosylation 3265 3091 6714 PMC10452461__F2 Fusobacterium affects chemotherapy drugs 7099 4615 100616274 PMC10452661__F2 Crosstalk between IL-6 signaling and the PI3K/AKT/mTOR pathway in EAOC 8289 406991 2475 5728 PMC10452836__F7 Reconstructed network using StringDB of the dynamic interactome of KRASG12C (grey halo) in HEK293 cells identified in the AP-MS screen 3845 55698 126374 3728 PMC10453069__F1 Clonal evolution of plasma cell dyscrasias 4609 472 7157 673 3845 PMC10453169__F5 Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma 6469 55733 6608 PMC10454149__F1 MiRNA-146a—A Key Player in Immunity and Diseases 7100 7097 7096 929 4615 3656 7189 PMC10454149__F3 MiRNA-146a—A Key Player in Immunity and Diseases 5966 4792 1326 3065 5971 4790 2033 1147 3551 5970 79155 PMC10454457__F2 Genes of the TLR signaling pathway observed in chicken thrombocytes 7099 7100 7097 929 7096 114609 4615 51135 7189 3663 3665 54106 51284 7098 7187 10010 PMC10454494__F3 Prostate cancer pathways [112] 9961 7018 572 5328 367 PMC10454639__F11 Regulatory pathway map of roots suffering Mn poisoning in soybean 847 831 2241 PMC10454712__F2 Diagram of genes and metabolite pathways associated with the major secondary metabolites of tea plants 2638 2641 353 PMC10454862__F10 S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NFKB/NLRP3 Inflammasome Signaling Pathway 6275 114548 79792 PMC10458543__F5 Protein interaction network created using STRING database based on Bos taurus genome 958 114548 4790 353376 54106 4615 7189 3661 925 7098 3627 920 942 3665 3569 51284 3456 7297 3454 51561 PMC10458946__F6 STING signaling pathway inhibition by STINGB in various ways and at various steps 29110 115004 1283 PMC10459054__F1 Typical pathway of miRNA formation 29102 54487 5901 PMC10459054__F4 Natural Products Treat Colorectal Cancer by Regulating miRNA 4314 5725 3178 PMC10459190__F2 Molecular mechanisms involved in atherogenic effects of Cd exposure 5444 3383 7412 3717 6774 114548 PMC10463219__F6 Resveratrol ameliorates insulin resistance by improving insulin signaling via the DDIT4/mTOR/IRS-1/PI3K/AKT/GLUT4 pathway 2475 54541 3667 PMC10467107__F7 Cardiac Toxicity Induced by Long-Term Environmental Levels of MC-LR Exposure in Mice 7018 2475 7045 PMC10468807__F1 lncRNAs are involved in tumor cell lipid metabolism by targeting different signaling pathways 6256 7038 100507246 728655 2180 50652 102800310 2475 PMC10471462__F3 Hippo pathway is involved in megakaryopoiesis (upper panel) and erythropoiesis (bottom panel) 387 4193 11167 3624 947 PMC10476361__F6 HDAC5 regulates MEF2A expression by influencing the ERK/EGR1 signaling pathwayVentricular remodeling induces cytoplasm translocation of HDAC5 10014 1958 4205 PMC10476430__F2 Underlying upstream and downstream mechanisms of cardiokines that mediate the heart-to-adipose tissue communication 255738 3949 2475 2260 26291 9969 11167 PMC10478265__F1 The cGAS-STING pathway in radiotherapy for non-small cell lung cancer 115004 3661 7124 PMC10478265__F2 The cGAS-STING pathway in radiotherapy for non-small cell lung cancer 115004 3661 4283 3627 PMC10478470__F2 HMGB1 and TLRs signaling pathway 3146 7096 10333 7097 7100 7099 4615 7098 54106 51284 51311 7124 PMC10478613__F2 Structure and function of kartogenin 865 861 655 4090 860 1499 PMC10478980__F1 Process of necroptosis 7124 8717 7186 8767 8737 11035 7099 197259 8772 114548 PMC10478980__F4 Process of apoptosis 7124 355 8717 8772 637 596 581 317 PMC10484938__F7 Metabolic remodeling in the brain and liver following STF 635 4548 3176 84706 57494 284716 2346 445 11113 435 PMC10486522__F1 Leptin and a schematic representation of leptin-induced signaling pathways 3667 8660 3717 9021 10645 2475 6774 PMC10486522__F2 Adiponectin and a schematic representation of adiponectin-induced signaling pathways 3667 8660 9021 6774 26060 55198 23411 2475 PMC10486640__F8 Identification of the expression of key genes of the TLR signaling pathway 7097 10333 54472 8772 114609 3929 929 23118 7099 7100 4615 7189 958 942 1513 7098 3661 6769 4609 941 51284 54106 3665 2159 PMC10486718__F3 Diagram illustrating the androgen-mediated signal transduction via integrins and the resulting biological activities 7018 2475 4582 PMC10487821__F9 Activation of the Wnt/Beta-catenin signaling pathway via lithium released from the IPN-Li hydrogel 4041 4040 2932 324 1499 PMC10487929__F11 Downstream effect analysis of molecules downstream ACE2 and upstream of the NISP in the network connectivity pathway map of ACE2’s downstream effects of simulated SARS-CoV-2 infection on predicted activity of SNCA and PD 5743 7124 3553 6347 6352 3569 PMC10487967__F2 CGAS–STING pathway in cell death, autophagy, and senescence 3661 29110 197259 115004 PMC10487967__F3 Different roles of the cGAS–STING pathway in host defense and various diseases 3661 115004 3725 1314 PMC10488294__F3 AML cell differentiation by S100A9 7099 6280 6279 PMC10489936__F4 Polysaccharides modulate liver bile acids (BAs)-related signaling pathways of metabolic associated fatty liver disease (MAFLD) 9965 2264 355 8213 PMC10490091__F7 Anti-Inflammatory Effect of Meriania hexamera Sprague by Targeting Syk Kinase in NFKB Signaling 7099 4615 6714 6850 PMC10492386__F10 EVs interacting with immune cells 7099 4615 114548 PMC10495336__F6 Working model of the oncogenic potential of SGG UCN34 2475 3611 1956 5156 947 10630 PMC10495745__F2 Activation of the JAK‐STAT signaling pathway in macrophages 3466 10379 3716 3717 7297 3566 PMC10495745__F3 Activation of PI3K/Akt and Notch signaling pathways in macrophages 5310 5728 7248 6009 2308 2932 9794 3516 PMC10495754__F1 RIPK3-CaMKII-mPTP signaling pathway 8717 7186 8767 8737 2746 2752 5836 11035 8772 90550 6262 197259 PMC10497558__F5 Aspartate, Arginine and Methionine metabolism 4507 4548 435 5009 4397 191 440 PMC10498433__F8 Lactate-induced oxidative stress 27198 3099 2539 50507 4314 6348 PMC10499775__F1 Illustration of the Fas-FasL pathway 355 8772 841 843 2475 PMC10502012__F5 Proposed mechanism for PHT1 mode of action 4615 51284 51311 54106 3663 64127 10392 80231 PMC10502727__F1 Basic research on chordoma 1956 4088 2475 PMC10503159__F9 Proposed model depicting the possible mechanism of bta-miR-223 on mediating inflammatory injuries and oxidative stress via regulation of NLRP3 inflammasome and Keap1/Nrf2 pathway 7099 114548 9817 PMC10505339__F4 BMP signalling pathway 4091 4092 4086 4090 4089 PMC10506410__F3 Vitamin D receptor deficiency may induce alopecia through the Ddit4/mTOR signaling pathway 7421 54541 7249 649 PMC10507626__F2 Molecular mechanism of inducing cognitive impairment in OSA patients through intermittent hypoxia (IH) 114548 4615 23621 PMC10507829__F4 Illustration of contributing factors of the signaling pathway for DDR1 in human adipose-derived MSC (A), (B), (C), which generated using ReactomeFIPlugIn in Cytoscape (B and C—enlarged parts of the image A) 861 860 864 PMC10508518__F5 KEGG simulated signaling pathway analysis 842 867 4117 324 100187761 100187907 100188776 7504 51426 27040 4118 4958 637 PMC10509026__F1 Schematic view of vitamin D (VD) signaling pathway mediated VD receptor (VDR) 120227 1591 1594 8074 5741 7421 PMC10510267__F8 MCL’s protection against PD-related peritoneal fibrosis 7040 4087 4088 PMC10511904__F3 Diagram illustrates how IMD activates various downstream signaling pathways through different CLR/RAMP receptor complexes 2548 4088 2638 PMC10512452__F6 IL-10 Exerts anti-inflammatory effects through STAT3 signaling pathway 3716 4827 6774 7099 4615 PMC10512581__F1 Hippo signaling pathway and therapeutic targets 4485 26524 9113 5054 1021 4001 10097 PMC10513393__F5 Cytokine-mediated signaling in T-cell lymphoma metabolic reprogramming 50615 149233 2475 PMC10514503__F2 S1P maintains the intestinal intraepithelial EC barrier 53637 55937 124976 9294 8698 6010 PMC10515252__F4 m6A modifications interact with the CRC inflammatory microenvironment 3486 3485 8835 7422 1969 56339 PMC10517567__F8 Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression 11197 1855 1856 2932 324 1499 7347 5515 607 51176 7089 7088 595 894 896 4609 8061 3725 83737 PMC10525272__F4 Vascular smooth muscle contraction pathway confirmed in the KEGG pathway analysis 1909 551 790 387 5739 133 1267 PMC10529739__F3 Signalling pathways and transcription factors involved in MSC senescence 9242 23408 349565 10135 23410 23409 2475 51547 22933 23411 51548 1499 64802 PMC10531451__F6 Heatmap of DEPs participated in the mevalonate (MEV) and methylerythritol phosphate (MEP) pathways of terpenoid biosynthesis 4597 727 3652 PMC10531837__F1 Melanin production 7157 6490 1638 7306 4157 4286 PMC10532491__F5 EGFR signal transduction pathway—an overview (modified after [94]) 1956 5979 238 558 3845 5290 5728 673 2521 4193 2475 7157 5925 PMC10534417__F1 Putative biosynthesis pathway of limonin 4598 3156 4597 3652 PMC10535221__F7 HAs induced LoVo cell apoptosis and inhibited the phosphorylation of Akt 355 637 581 572 PMC10536292__F9 Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells 3949 255738 2308 2645 2194 3156 2932 PMC10541724__F7 Schematic illustration showing that CSSC-EVs mediated the LESC phenotype by regulating the Notch1 pathway through miRNAs 4851 100302276 3280 PMC10542901__F1 Endothelium as initiator and target of type I IFN responses 6772 6773 10379 115004 7124 3661 3659 29110 3627 847 PMC10542959__F4 FOXM1 may be involved in diabetic nephropathy by regulating signaling pathways such as NFKB/NLRP3 and Wnt/Beta-catenin 23409 2305 114548 1499 595 PMC10545718__F2 Genetic deletion of lipid biosynthetic and metabolic enzymes on adipocyte metabolism 144110 94103 5140 7038 948 PMC10545783__F1 Bacterial PSAs transduce signals through innate receptors to modulate immune responses 7097 7096 7099 4615 3661 920 PMC10545798__F1 Landscape of cholesterol homeostasis regulation 3949 22937 19 9619 3156 38 PMC10545798__F6 Internal and external factor regulation of cholesterol metabolism 7124 125170 5728 3156 22937 2475 3949 255738 19 9619 PMC10546030__F2 Methionine biosynthesis and metabolism: Diagram of metabolic pathway showing aspartate family pathway, metabolism of methionine and cysteine biosynthesis 1725 157739 4397 PMC10546379__F4 SIK1 inhibits tumor cell EMT by suppressing Beta-catenin signaling pathway and the expression of Twist 1 150094 1499 51176 6925 PMC10548138__F2 PI3K /Akt in COPD regulation 7808 260431 3569 7124 PMC10548218__F1 FGF effects in breast cancer cells 2246 2254 2247 2252 2255 2885 10818 PMC10551637__F1 Targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy 594857 140885 961 PMC10551897__F11 KEGG pathway diagram for PI3K-AKT signalling pathway 7249 5066 3667 613 6850 930 27159 373073 5728 672 5934 572 PMC10551897__F12 KEGG pathway diagram for EGFR tyrosine kinase inhibitor resistance pathway 1956 5728 126669 673 100506123 PMC10551897__F9 SX Components-top 8 Targets-Pathways Network (Green hexagon node shows SX, pink circle nodes show the components, purple rectangle nodes show target genes, orange V-shape nodes show pathways and edges show the interaction between two nodes) 5747 367 6774 7157 2064 2033 1956 6714 PMC10552298__F1 , Hypothetical VOC production pathway originated from lipid peroxidation of membrane lipids 4015 3939 7808 PMC10552637__F1 Metabolic cycle of tetrahydrofolate (THF) and the one-carbon (C1) metabolic pathway 4522 25902 160428 10797 6472 275 PMC10556370__F3 Mechanisms underlying TAX-mediated neuroprotection against AD or CAA 23411 351 348 23621 PMC10556577__F1 TGFB signaling pathways (Activin and Bone Morphogenetic Protein) 60 4087 54498 PMC10558021__F2 Cyclophosphamide metabolic pathway 1576 1555 1559 1557 1577 PMC10558228__F3 NLRP3 signaling pathway and targets of inhibitors against neuroinflammation in AD 7099 114548 79792 PMC10558228__F5 Targeting inflammatory signaling pathways with drugs shows promise in AD treatment 114548 351 4280 729 6774 PMC10558709__F7 The main findings on HMEC-1 10724 8473 847 1728 PMC10559578__F2 Production of IL-1B and its transduction signaling pathway 10628 79792 114548 23118 4615 51135 3654 7189 PMC10559995__F3 Estrogen metabolism pathway in humans 1312 412 54659 54600 PMC10560454__F1 tFNAs improve hUMSC chondrogenic potential through the regulation of the PI3K/AKT pathway 2475 387 176 1280 6662 PMC10561294__F7 Construction of PPI networks 4314 6364 2921 597 1440 2920 7124 PMC10564417__F7 Schematic diagram showing the proposed mechanisms by which exosomal miR-486-5p derived from M2 macrophages regulates the osteogenic and adipogenic differentiation of BMMSCs 4087 4088 4089 860 PMC10564428__F8 Myeloid-specific knockout of SHP2 regulates PI3K/PLCG signaling pathway to protect against early myocardial infarction injury 4280 4615 7124 3458 10461 PMC10568316__F2 Mφ-related inflammatory signaling pathways in NEC 3146 7099 79792 3654 51135 4615 7189 114548 7124 PMC10571577__F3 Acquired mechanisms of resistance to MET-Is 1950 3084 3845 1956 673 PMC10571713__F1 Lipid sources include the de novo fatty acid synthesis pathway and exogenous lipid uptake 47 2194 355 PMC10572156__F7 Beta-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells 2475 2194 6319 5686 847 7124 581 PMC10572622__F3 Representation of part of phenylpropanoids and oleuropein biosynthetic pathway in olive fruits 1896 1674 10763 PMC10572663__F3 Hypothetical contribution of EMT-like process to the pathophysiology of RA 4087 2475 861 26136 4314 4318 PMC10572663__F4 Hypothetical contribution of EMT to the pathophysiology of pSS 4087 7040 26136 9839 4318 1278 1281 PMC10572711__F2 Major and other possible molecular pathways associated with NLRs in IBD 64170 22861 114548 140609 171389 199713 58484 64127 91662 7099 4615 3654 7189 57506 79671 834 79792 55054 1432 5599 PMC10572723__F3 Interacting compounds and PTMs of PPARG that regulate its function in the endothelium 1956 8554 2308 1499 PMC10573125__F1 The JAK-STAT signaling pathway by LNK in hormone receptor-positive breast cancer and non-tumor cells 3570 3717 6774 5618 5617 595 4312 5292 PMC10573127__F2 Molecular pathways involved in multiciliogenesis 4851 1874 345643 4602 10309 5991 5990 2302 4163 PMC10573510__F6 Asthma pathway 958 324 7124 5226 4155 2056 PMC10583183__F11 Mechanism that HRF prompts pyroptosis via CaSR/NLRP3/caspase1 signaling pathway under MI/R conditions 79792 846 114548 PMC10590753__F11 Differentially expressed proteins and metabolites KEGG annotation and visual analysis in the purine metabolism pathway 5550 351 100 4975 PMC10594068__F3 Bone is a tissue that consists of diverse cell types (osteoblasts, osteoclasts) that interact in a complex manner 5741 9242 5745 PMC10603966__F5 Schematic view showing melatonin-mediated actions in stroke 7097 7099 7186 3717 6774 9817 23410 847 4353 23411 114548 PMC10604364__F3 Illustration depicting the formation and fate of hybrid cells 9242 1499 7099 PMC10604902__F1 Oxidative stress from dysregulated NOX activation and mitochondrial dysfunction regulates the signaling pathways involved in initiating and maintaining AF 27035 3579 2919 50507 6262 960 6774 PMC10604974__F3 Activation mechanism of the NLRP3 inflammasome 7124 4615 57506 114548 79792 PMC10604999__F1 Scheme illustrating the main hippocampal mechanisms observed in the diabetes-related depression 2638 627 572 581 759 7099 4615 PMC10605254__F4 PDLIMs and integrin signaling pathway 64236 9124 9260 8572 4008 PMC10605254__F5 PDLIMs and TGFB signaling pathway 4008 387 10371 10611 4087 4088 4089 9260 4086 4090 PMC10605254__F6 PDLIMs and MAPK and NFKB signaling pathway 27295 10611 64236 3985 4008 9124 8572 9260 6774 PMC10605306__F1 Interleukin-33 signaling pathway 90865 4615 7189 51135 PMC10605590__F7 The potential non-genomic P4 action in colorectal cancer 29937 10424 5241 26135 3577 PMC10605613__F3 Cellular regulatory pathways involving PrPC protein in cancer 331 2534 6304 4320 4318 2316 PMC10606123__F1 Underlying mechanism of histone deacetylases in regulating ovarian cancer metastasis 8841 23411 9734 10014 1499 3146 10013 3169 9314 9759 23410 PMC10607207__F1 Neuroprotective intracellular signaling pathways in the central nervous system involving TRPC6 activation 7225 80228 627 57620 PMC10607711__F2 Propagation of pressure in the epidermis and certain mechanotransducers involving the modulation of mechanical stimuli in keratinocytes 846 59341 9780 PMC10608450__F5 Protein–protein interactions between 341 members of antimicrobial peptides in Trachinotus ovatus 132 1463 351 1113 797 9547 5319 PMC10609794__F2 The PRG4-CD44 axis in mitigating the pro-inflammatory and pro-fibrotic signaling pathways in DJDs 960 114548 4087 4088 4089 7018 PMC10609905__F1 Vitamin D synthesis pathway 1594 1591 2247 4619 7421 PMC10609929__F2 Modeled DDIs for phenytoin 1559 1557 1576 PMC10610144__F7 SBP effects on BMP2-Smad1/5/9-Runx2 signaling pathway 4086 4090 4093 650 860 6678 PMC10610230__F7 Mechanism underlying the therapeutic effect of PT on IDD 7124 5743 2353 3725 1906 1280 176 PMC10610499__F2 TLR4 downstream signaling pathways 3929 929 7099 4615 7189 3661 3569 7187 PMC10610499__F3 Liver manages a complex antigenic load from the blood, relying on immune tolerance mechanisms and mainly LPS tolerance 4615 7189 7099 PMC10610897__F7 Interaction network of genes and co-expressed lncRNAs involved in IAV replication regulation in MDCK cells 9076 7297 3716 3717 91543 10456 3059 6772 10379 PMC10616926__F1 Schematic drawing of the major neuroprotective signaling pathways regulated by ghrelin and GHS 948 596 581 PMC10618387__F3 Apoptosis is mediated by intrinsic and extrinsic pathways 572 637 355 8772 8717 1540 7939 79792 PMC10618387__F5 Crosstalk between the signaling pathway of pyroptosis, apoptosis, and autophagy 79792 83667 2475 114548 PMC10619560__F4 Biosynthetic pathway of caproic acid and other organic acids in C. butyricum GD1-1 3045 100187828 847 PMC10620037__F3 IL-37 inhibits liver fibrosis 4088 4086 3397 10716 PMC10620037__F4 IL-37 inhibits hepatocellular carcinoma (HCC) 619501 6009 7249 2475 PMC10627266__F5 CEBPB increases inflammation/SASP independent of DDR pathway to promote senescence 1051 545 472 3569 2920 6374 3592 PMC10631767__F1 Interactions between CAFs and CCA cells 1839 3082 1956 80310 7422 7852 6774 7424 PMC10635949__F5 Effect of BD exposure during adolescence on skeletal muscle metabolism and myokine secretion 3667 2475 2309 8408 627 26291 3976 6678 PMC10636769__F2 IORT regulates the proliferation of microRNA-223, thereby reducing EGF levels and ultimately attenuating the EGFR signaling pathway 2475 1950 1956 PMC10647353__F4 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis 182 28514 84441 55534 PMC10647353__F6 Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis 4087 4088 4089 472 PMC10647767__F4 Developments in Genetics: Better Management of Ovarian Cancer Patients 324 1499 6010 PMC10647767__F6 Developments in Genetics: Better Management of Ovarian Cancer Patients 3082 6774 2475 PMC10647767__F8 Developments in Genetics: Better Management of Ovarian Cancer Patients 1950 2475 6774 PMC10648128__F5 DEGs belonging to the gap junction signaling pathway in the hippocampus (magenta) and frontal cortex (red) of OXYS rats at PND3 and PND10 761 27040 8544 PMC10648403__F6 Expression profiles of genes involved in the phenylpropanoid biosynthesis pathway 1359 1357 1312 790 PMC10648981__F3 Jasmonates in coordinating secondary with primary metabolism 4015 471 3652 PMC10650444__F8 Compound 6b for promoting apoptosis of HepG2 cells 7468 4193 581 PMC10669090__F2 The influence of risk factors on the formation of peak bone mass 53366 860 50964 1356 3479 PMC10669226__F4 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages signaling pathways is predicted to be upregulated in EVPs from aged animals 3458 140885 4139 5596 7124 6772 4688 PMC10669348__F3 Schematic and simplified overview of the intracellular transduction cascades induced by 5-HT2AR TrkB and Sig-1R receptor activation by psychedelics 627 2885 2475 PMC10669501__F2 Interplay of NRF2 in Kupffer cells and HSCs during the progression of chronic liver disease 9817 7045 4087 4088 PMC10670053__F1 Most common signalling pathways active in muscle and adipocytes during cancer-associated cachexia 3479 7124 3976 4087 4088 2475 7350 3977 PMC10670368__F2 SHP2 is critical in regulating RAS/ERK, PI3K/Akt, and JAK/STAT signaling pathways in cancer cells 2885 1445 3845 2475 6714 PMC10670380__F3 Multi-level functional integration of extended regions of the human genome, above and beyond individual noncoding RNAs 4280 283131 378938 348 109136579 109136578 4841 PMC10671144__F1 Carboplatin molecular network in cancer 3651 4087 30009 8626 2099 1027 6720 2146 5970 3725 860 4790 3164 6886 1026 672 2033 PMC10671169__F7 NXC736 Attenuates Radiation-Induced Lung Fibrosis via Regulating NLRP3/IL-1B Signaling Pathway 1901 8698 4087 4088 114548 4089 PMC10671302__F4 Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases 7422 8205 1116 960 6778 PMC10671441__F8 S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells 1440 7054 3082 4609 355 8837 596 319 11201 PMC10671474__F2 Common mechanisms of secondary endocrine resistance in advanced ER+ breast cancer 5728 6790 1956 4763 2475 PMC10671516__F1 Paracrine-mediated signaling between granulosa cells and oocytes 9210 4090 4086 2661 4087 4088 5806 3037 6770 581 842 7157 PMC10672452__F1 LPS-induced inflammatory response of the innate immune system and the anti-inflammatory effect of LPS-binding peptides/proteins from marine invertebrates 3929 929 4615 PMC10673274__F1 Sites of cellular PPi formation and details of galactose metabolism 5464 27068 130589 7360 2582 2592 PMC10674583__F1 Nrf2-keap1/ARE signaling pathway 9817 847 4094 1728 PMC10674663__F7 Comparative Analysis of Cd Uptake and Tolerance in Two Mangrove Species (Avicennia marina and Rhizophora stylosa) with Distinct Apoplast Barriers 4602 1312 3240 PMC10674800__F6 Transcriptomics and Physiological Analyses Reveal Changes in Paclitaxel Production and Physiological Properties in Taxus cuspidata Suspension Cells in Response to Elicitors 5066 4598 4597 3423 3652 PMC10675221__F3 Direct targets of the ethyl acetate extract from decoction of Sargentodoxa cuneata (EAdSc) action on the NOD-like receptor signaling pathway 100188776 90550 10010 6503 3558 PMC10675562__F6 HS potential inhibitory mechanism of GA via TGFB/Smad signaling pathway 4089 4087 4088 4092 PMC10685161__F3 Effect of UPR-AGR2 signaling pathways on goblet cells during ETEC infection 4583 10551 1956 PMC10686715__F5 Exosomes secreted by different sources of MSCs regulate the inflammatory microenvironment after myocardial infarction 9242 2242 604 2146 10018 PMC10688450__F4 Link between U2AF1 and NFKB signalling in MDS and AML 51135 7307 6427 23451 841 6885 4615 PMC10688769__F2 Cell-produced SASP affects OA 1789 9242 6662 1280 11096 9507 PMC10688769__F4 miRNA alterations affect cartilage synthesis 9242 11096 1280 6662 PMC10705282__F2 Exogenous pathway is a process for delivering triglycerides to peripheral tissues using chylomicrons and VLDLs 3949 4023 348 PMC10705282__F4 In PTC, glycolysis is crucial for tumor growth 6774 3717 79068 PMC10706414__F1 Interleukin (IL)-37 maintains its anti-inflammatory outcomes by limiting IL-18RA from adhering to IL-18 and by attracting the orphan decoy IL-1R8 to the IL-18R/IL-37/IL-1R8 complex 4615 4088 2475 5728 114548 2534 6774 6778 PMC10706706__F6 DEGs expression pattern diagram of JA biosynthetic pathway in mustard leaves after beet armyworm larvae chewing 4015 314 8639 PMC10706788__F10 Pathway of purine metabolism by EHP in the early stages of infection 351 23440 133 57817 PMC10706788__F11 Pathway of glutathione metabolism by EHP in the early stages of infection 51056 5182 5184 PMC10706788__F13 Pathway of glutathione metabolism by EHP in the late stages of infection 619537 51056 5182 5184 PMC10706934__F1 Hypothetic signalling pathway triggered by FK506 4086 4090 27302 PMC10707854__F2 Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis 4092 4088 4087 4089 PMC10707854__F3 Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis 2932 324 1499 1277 PMC10723408__F1 Workflow and methodology used in this work 4397 5212 6418 11113 2010 PMC10731584__F7 Simplified de novo sphingolipid biosynthesis pathway 2531 7357 410 2581 79152 PMC10733979__F1 Key cellular metabolic pathways in which NAD(P)H and FAD are involved, including glycolysis, the TCA cycle, oxidative phosphorylation, fatty acid oxidation and synthesis, and the glutathione pathway 23530 57716 7350 PMC10739988__F2 Advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review) 1956 2475 6774 PMC10740485__F7 The proposed mechanism of Nrf2 in osteoporosis 7189 100187907 4772 81501 PMC10740511__F5 Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer 100847014 494334 1855 11317 23220 3714 84441 1857 5664 2648 8650 5663 2033 4242 196403 1488 8850 4855 23385 4854 120237 1856 3066 4853 1387 4851 9253 113878 22938 151636 9612 388585 PMC10740672__F8 Growth suppression mediated by p53 5728 7248 7249 6009 PMC10740823__F9 Graphical abstract of the mechanism 4092 4087 4088 4089 1278 PMC10740873__F2 Ihh signaling pathway in regulating osteoblast differentiation (refer to Pan et al 3549 5727 6608 2736 2737 860 6662 PMC10741038__F5 PC biosynthesis in S 283871 5662 5091 780904 100379198 PMC10741879__F7 Schematic model showing the tumor-progression-promoting interaction between CRC cells and TAMs 6355 6354 6347 2475 3939 3920 PMC10742271__F4 Signaling pathway involved in the osteogenesis process due to Mg effect 4703 4772 1499 1385 2736 9242 84061 54822 PMC10742434__F1 Gut microbiota–host interplays in tryptophan and tyrosine metabolism, which affect mood and emotional states 7054 1621 438 PMC10742465__F7 The proposed cardioprotective mechanism of hydrogen after CIH exposure 2242 26234 9817 PMC10743075__F9 N-3-PUFAs decreased mRNA expression of key enzymes of fatty acid biosynthetic pathway 2194 2271 2242 6955 3073 PMC10743075__F10 n-3-PUFA administration decreased mRNA expression of pro-inflammatory cytokines, as documented in the TNF signaling pathway 7124 8772 836 3976 3600 7018 10293 2353 8717 4703 64127 197259 6401 7187 248 PMC10743093__F3 Schematic illustration highlighting targets of senotherapeutics including senolytics and senomorphics 10457 2475 4303 PMC10743408__F3 Mechanistic illustration of downregulation of interferon-responsive genes and JAK/STAT1/2 signaling pathway 3454 3455 7297 3716 6772 6773 10379 4599 3434 9636 3669 3433 4939 3437 91543 3659 PMC10743522__F3 The signaling pathways regulated by phase separation during development 7003 4609 1499 652 79923 PMC10743556__F2 Keap1/Nrf2/ARE signaling pathway 9817 847 1728 PMC10743592__F3 Presentation of association between apoptosis and necroptosis 581 596 637 8772 8737 8717 11035 197259 PMC10743675__F3 Osteobiologies for Spinal Fusion from Biological Mechanisms to Clinical Applications: A Narrative Review 5727 3549 6608 9794 847 100188776 860 6662 4041 4040 PMC10743706__F2 Biosynthetic pathways of BR 1362 148362 1431 PMC10744776__F4 Anticancer properties of glycyrrhizinic acid in cervical cancer models 8772 3146 595 3280 596 100653365 581 572 5132 100187761 PMC10744863__F1 Pathophysiology of acquired aplastic anemia (AA) 3458 6774 50943 355 PMC10745077__F6 Pro-apoptotic Bax-induced release of cytochrome stimulates the caspase signaling pathway in the mitochondria, resulting in enhanced hepatic cell apoptosis 581 842 836 PMC10745821__F9 Proposed model of the signaling pathway induced by the CSHE treatment 51 2308 2194 PMC10746942__F1 SAMMSON via different mechanisms exerts its oncogenic roles in melanoma 79800 101927152 2146 3170 PMC10746942__F2 The function of SAMMSON in different cancers 2146 101927152 693207 10873 56998 6667 PMC10747773__F4 HCV-induced ROS/JNK/Itch signaling pathway promotes VSP4A polyubiquitylation, leading to enhancement of VPS4A ATPase activity, thereby upregulating the release of HCV particles 83737 57132 27183 PMC10748259__F6 Molecular mechanisms leading to the detection of viral genome 115004 54106 7098 3665 51284 51311 114548 3661 7186 7188 7187 9618 57506 29110 PMC10748259__F7 Involvement of metabolism in viral genome detection 54106 115004 51284 51311 7098 3665 29110 3661 7188 7187 7186 57506 PMC10748259__F8 Antiviral effectors and cell metabolism interactions 6773 3455 3454 7297 3716 3661 163702 9636 4938 6041 9023 2537 PMC10751873__F2 High expression level of CRNDE contributes to CRC by upregulating the signaling pathways such as Ras/MAPK, Wnt/Beta-catenin 221092 643911 2146 1847 1026 6934 29028 1869 1499 PMC10758155__F6 Huaier suppresses cell viability, migration and invasion in human non-small cell lung cancer via lncRNA DLEU2/miR-212-5p/ELF3 axis 8847 1999 4854 PMC10774482__F1 Canonical signaling pathways of cGAS 115004 29110 3661 PMC10777970__F7 Hedgehog (Hh) signaling pathway 6608 2735 5727 51684 PMC10778012__F1 Oncogenic signaling can drive changes in the transcription of tRNA genes 2475 4609 4553 PMC10778204__F2 Representation of the important miRNAs that effectively regulate the Notch signaling pathway in glioblastoma 4851 4853 7405 10683 PMC10778207__F4 Src intracellular signaling pathway and various cellular processes controlled by each pathway 6714 6774 2885 2475 387 PMC10778465__F1 The antitumor effect of SST receptors after ligand binding 6755 6752 6751 6754 6753 6750 6714 581 PMC10778864__F2 VEGF-VEGFR signaling pathway 7423 7422 5281 7424 2277 PMC10779012__F2 Insulin-like growth factor 1 (IGF1) signaling pathway and major downstream effects on cancer cells 2475 3480 3479 4193 572 2002 PMC10779133__F2 Neuroprotective effects of KBs and KD by providing energy source and improving mitochondrial dysfunction in the brain 23410 22933 23411 2308 PMC10779157__F3 SHP-1-mediated inhibition of the JAK/STAT signaling pathway 2056 3717 2057 3716 7297 6772 6773 PMC10779188__F1 BRAF signaling pathway and targeted therapies in the BRAF pathway 2885 673 2475 PMC10779236__F4 Main molecular mechanisms regulated by sialic acid 7099 10020 4615 847 627 7124 1728 PMC10779236__F5 Possible action mechanisms of sialic acid mediated by the signaling pathway and gut environment 10020 7099 4615 847 627 1728 PMC10779351__F3 NADPH in Insulin Secretion from Pancreatic Beta-Cells 2539 29843 4335 PMC10779699__F2 Proposed model for the pathogenic role of the NLRP3 inflammasome signaling pathway in RA and its clinical implications as the therapeutic potential 7124 114548 5806 79792 440823 10068 PMC10779870__F11 KEGG TNFA signaling and its association with the PI3K-AKT signaling pathway 7124 7186 7187 PMC10779870__F13 Proposed molecular effects of fucoxanthin through modulation of genes and proteins of the PI3K-AKT signaling pathway in TNF-Alpha-stimulated MDA-MB-231 and MDA-MB-468 cells 5164 2308 2002 5921 3265 5747 1978 387 114609 3667 5595 1975 PMC10779880__F4 Mechanisms of treatment of neurodegenerative diseases (NDs) using capsaicin and N-oleoyldopamin (OLDA) 1270 2475 2166 7442 PMC10780299__F3 Saponins activate the TLRs signaling pathway through TLRs, upregulate class I and II MHC molecules in APCs, and promote antigen capture, processing, and presentation 942 941 920 940 324 PMC10780960__F3 Comparative analysis of differentially methylated regions and differentially expressed genes in the metabolism pathways related to sink-source regulation 64641 1879 2582 412 PMC10788715__F5 MiRNA-766-3p inhibited gastric cancer via targeting COL1A1 and regulating the PI3K/AKT signaling pathway 1277 1284 1285 1282 1280 3910 1292 3908 1291 1286 3913 1288 1293 3918 PMC10789540__F5 IFITM3-mediated activation of TRAF6/MAPK/AP-1 pathways induces acquired TKI resistance in clear cell renal cell carcinoma 10410 7189 3654 PMC10792990__F4 Mechanism of GB on independent risk factors for atherosclerosis 7038 3717 6774 7099 PMC10796102__F6 Action of cerebral lymphatic system in brain diseases due to impaired renal function 196 85451 80824 1847 1850 1843 7054 PMC10804064__F2 Comprehensive Review of the Key Characteristics of the Genus Mentha, Natural Compounds and Biotechnological Approaches for the Production of Secondary Metabolites 4598 10654 3652 727 PMC10807637__F6 HDAC inhibitors target IRS4 to enhance anti-AR therapy in AR-positive triple-negative breast cancer 3845 8471 2475 595 PMC10813042__F3 Antioxidant mechanism of estrodiol 1956 6714 246751 847 PMC10813163__F1 Schematic illustration of leptin-induced signaling pathways 3717 6774 2475 PMC10813482__F1 DNA modification of MSCs in SONFH 9242 8321 5243 860 PMC10813911__F3 Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury 2670 4087 4088 PMC10814071__F4 Regulatory Gene Network Associated with the Ameliorative Effect of Oat Antibacterial Peptides on Rat Colitis 2475 6497 4026 PMC10814159__F5 Activation of the Hh/GLI signaling pathway 6608 51684 2932 595 596 PMC10814280__F2 : promotion : inhabition 2840 596 581 PMC10814963__F4 Proposed model for Fyn-CD133 signaling to the PI3K pathway induces melanoma intrinsic and acquired resistance to anti-cancer agent in melanoma cells 673 5728 2534 2886 2885 4193 PMC10815231__F2 Therapeutic implications of miRNAs and lncRNAs in AKI 861 114548 5465 3099 104472715 387066 204851 8737 2002 64083 6347 647979 PMC10815231__F3 Action of ncRNAs in CKD 7248 10725 2475 PMC10815231__F5 Graphical summary of the mechanisms of action of microRNAs and lncRNAs in renal fibrosis 2475 5213 643911 7006 100124696 PMC10815326__F7 Different patterns of inflammatory gene activation in cerebral cortex and cerebellum of Npc1−/− mice 4864 7099 51192 2921 200734 10148 6387 6354 3627 6372 PMC10815665__F2 CXCR signaling pathway 3576 6372 2919 2920 6373 4283 3627 6387 10563 58191 643 10663 3717 3718 7018 PMC10815665__F3 Proposed conceptual framework for the involvement of CXCR signaling in modulating Th1/Th17-driven pathologies 7852 3579 3577 3458 10663 PMC10815772__F2 Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers 2261 3815 5979 100187907 10818 2885 2475 PMC10816220__F1 Transforming growth factor B (TGFB) and bone morphogenetic proteins (BMP) signaling pathway 4086 4090 4087 4088 4092 64750 4089 4091 387 2475 PMC10816282__F6 Transcription response to APS of the JNK/MAPK (A), JAK/STAT (B), Toll and Imd (C) signaling pathway genes in the control and GagrRNAi females and males 355 4312 474168 PMC10816399__F2 IL-6R interaction with gp130 for Stat3-mediated inflammatory target gene expression 6774 4312 9021 8651 3479 PMC10816532__F3 Potential mechanisms underlying the inhibitory effects of magnesium on vascular calcification 846 54822 1499 PMC10816780__F15 Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs 3717 6774 7423 4609 596 355 7424 PMC10818625__F1 Mechanism by which pathogenic infection causes cell necroptosis 3466 355 7099 11035 197259 7098 3716 8772 3717 8717 7186 8737 6772 23118 257397 3659 81030 PMC10818625__F2 Pharmacological interventions against necroptosis in pneumonia 355 8737 11035 197259 7099 PMC10818876__F2 Signaling pathways triggered by traditional medicine-derived SCFAs 2475 4615 114548 196 79792 3091 6774 PMC10819295__F2 Possible signaling pathways activated by ORF8 23765 4615 3661 7189 3569 PMC10820593__F5 Common adjuvants and proposed mechanisms 351 115004 3661 3665 7124 PMC10820833__F2 Cellular senescence pathways affected by Tax 545 472 6741 PMC10834963__F8 Proposed signaling mechanism for the effects of amlexanox on LPS-induced neuroinflammation in BV2 microglial cells 6774 6347 3627 PMC10834974__F5 Novel preliminary metabolomic panel for IHD diagnostics and pathogenesis 729 717 718 727 PMC10835878__F10 Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells 2475 3099 3939 7019 PMC10837142__F5 Terpenoid biosynthesis pathway in T 4597 6713 2222 9453 PMC10838060__F3 cGAS-STING and JAK–STAT pathways 3716 7297 84659 115004 3661 29110 8651 9021 11274 PMC10838060__F4 Other media for activating STING 5591 115004 3428 7189 29110 3661 619537 PMC10838060__F6 cGAS-STING and pyroptosis 9447 114548 79792 29110 3661 283120 PMC10838060__F7 cGAS-STING pathway and metabolic reprogramming 730249 5164 5166 PMC10838060__F9 CGAS-STING pathway in diabetic complications 114548 29110 115004 PMC10838202__F5 mRNA-seq results of KEGG pathway enrichment analysis and western blot results 1674 7124 7975 114609 6955 351 4803 PMC10838448__F2 RANKL/RANK signaling pathway activates NFATc1 306 7189 602 7874 170954 150372 4772 3091 PMC10838672__F6 Smo‐driven canonical Hh signaling pathway and targeted inhibitors 6608 5727 374654 51684 2737 2736 PMC10838672__F1 VEGF protein family and receptor signaling pathway 7422 5281 7423 7424 PMC10838672__F2 RTKs and its related downstream signaling pathways and their targeted therapies for hepatocellular carcinoma 1950 3082 1956 3717 5728 2475 PMC10838672__F4 Wnt on and Wnt off state of Wnt/B‐catenin signaling pathway and therapeutic strategies based on them 4041 4040 1499 2932 324 PMC10838672__F5 JAK/STAT signaling and targeted inhibitors 3716 3717 3718 7297 6772 6775 6774 6776 6778 6777 6773 PMC10840486__F9 Schematic illustration showing synergistic calcium supplementation and SIM delivery strategy for osteoporosis 650 860 2152 PMC10840489__F3 Endosomal and cytoplasmic viral RNA sensing by RLRs and TLRs 57506 51284 3661 3665 7098 4615 PMC10840523__F1 Therapeutic Potential of Fingolimod in Diabetes Mellitus and Its Chronic Complications 1901 9294 1903 8698 53637 PMC10844364__F2 Novel acylations participate in head and neck cancer metastasis 54503 5873 1956 8841 7038 7018 PMC10844364__F4 Novel acylations act as significant regulators in HCC metastasis 4329 1431 204 3569 2335 3690 7019 PMC10845297__F3 Fibroblasts of metastatic organ in PMN formation 7128 2191 9358 6346 1237 PMC10845654__F8 Working model 164091 4280 581 PMC10846991__F4 Overall signaling pathways between podocytes and glomerular endothelial cells (GECs) 7852 7422 285 284 6387 PMC10850749__S1 Garcinone C attenuates RANKL-induced osteoclast differentiation and oxidative stress by activating Nrf2/HO-1 and inhibiting the NF-kB signaling pathway 4772 4318 1513 PMC10851593__F4 Lignin synthesis pathway map 3630 790 1312 PMC10853571__F3 Molecular signaling schematic of cytokine hypothesis in the pathogenesis of MDD 114548 7351 2932 6774 1499 3569 6925 PMC10853571__F6 Molecular mechanisms of tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin/norepinephrine reuptake inhibitors (SNRIs) and ketamine 627 814 2475 PMC10853679__F7 Graphical abstract to present metabolic heterogeneity in central and peripheral tumour areas of LumA and LumB 5320 4023 1956 5290 7298 5166 PMC10854112__F10 Schematic showing the preliminary mechanism of Gnao1 in SCs regulating SC differentiation and myelination 2775 108 5563 1959 116448 5454 5453 PMC10854597__F8 FAK signaling in FLNC cardiomyopathy 2318 5156 23239 PMC10854699__F2 Cachexia-related pathways in skeletal muscle: The mTOR (mechanistic Target of Rapamycin) signaling pathway, which is initiated by activated Akt and inhibits the phosphorylation of FoxO, facilitates the process of protein synthesis 3479 3480 3667 2475 2660 7124 4087 4088 PMC10854812__F5 Function of CD133 protein 2534 2885 2886 5728 4893 4193 PMC10854812__F8 Models of both non-receptor tyrosine kinase- (NRTKs) and receptor tyrosine kinase-mediated signaling pathways in tumor progression and drug resistance 64798 2534 2885 2886 4893 5728 6774 673 4193 PMC10854812__F10 Selected agents targeting the Fyn/CD133/PI3K/Akt/mTOR pathway 2475 2534 5728 7249 6009 PMC10855445__F3 Interaction between ALR, NLR, and cGLR (cGAS/STING signaling pathway) 197358 115004 27005 9447 3661 79671 114548 PMC10855599__F2 JAK-STAT signaling pathway and PI3K-AKT signaling pathway that affect AD 3667 3597 3716 7297 6778 6774 PMC10855920__F2 Innate and adaptative immune systems 7097 4615 23118 257397 7189 3661 7187 7098 920 3466 3566 PMC10855920__F4 Molecular pathways hypothesized to be involved in the pathogenesis of nonspecific orbital inflammation 90865 7124 3458 4615 6761 3566 3466 920 23118 7189 3661 7187 6361 2833 PMC10855951__F5 Transcriptomic Analysis Provides Insights into Candidate Genes and Molecular Pathways Involved in Growth of Mytilus coruscus Larvae 6608 11127 374654 51684 2737 2736 1874 4087 4088 4089 PMC10857877__F6 RND3 induction and interaction with TLR4 and IFNG receptor signaling in activated proinflammatory macrophages 390 4851 3627 PMC10860311__F1 Ovarian clear cell cancer carcinogenesis 8289 5290 5728 PMC10860821__F1 Three types of pyroptosis pathway 4615 114548 129607 79792 7099 8737 PMC10864729__F6 Predicted downstream pathway of MIR17HG 407975 4193 51194 3672 PMC10865418__F5 Schematic diagram illustrating the hypothesis of signaling regulation in aGVHD 2475 920 50943 PMC10866932__F7 SALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification 56339 1499 57167 960 595 PMC10869479__F3 P2X7-mediated signaling pathway 114548 5879 351 3553 PMC10869786__F7 The mechanism by which FXR promotes NSCLC metastasis 3572 3717 6774 PMC10869798__F2 Microglial activation and neurodegeneration 54209 3553 7124 6850 PMC10869801__F0 Macrophage TSC1-mediated AKT/MST1/NRF2 signaling pathway in I/R-triggered liver inflammation 3146 7099 7248 4485 9817 7189 PMC10870461__F16 Signal pathways related to CALD1 mapped by KEGG database 1909 551 790 387 5739 133 1267 PMC10873211__F9 Nasal Administration of bFGF-Loaded Nanoliposomes Attenuates Neuronal Injury and Cognitive Deficits in Mice with Vascular Dementia Induced by Repeated Cerebral Ischemia‒Reperfusion 581 9817 1728 PMC10873402__F4 Enrichment analysis for leading target genes 9242 920 5680 PMC10874285__F1 HCV inhibits the innate immune response 7189 3454 3455 115004 29110 57506 9021 8651 4615 PMC10874285__F2 Interplay between HCV-induced autophagy and host innate immune response 115004 29110 3661 7189 PMC10874560__F3 Representative bacterial-origin immunostimulants signaling pathway 7099 7100 4352 114609 4615 3661 3240 58484 54106 3654 7189 3665 PMC10874752__F13 miR-140-y targets TCF4 to regulate the Wnt signaling pathway and promote embryonic feather follicle development in Hungarian white goose 6925 2932 324 1499 PMC10875024__F6 CCN3 involvement in cell apoptosis and FGFR2 signaling pathways 7157 54971 51230 4856 5457 5458 25946 10817 2263 10818 8626 5770 PMC10875059__F1 Metabolic pathway of risperidone 1565 1576 1577 5243 54658 PMC10875059__F3 Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future implications 5243 1576 1565 PMC10876676__F2 Upon infection with HIV, the virus infiltrates cluster differentiation positive (CD4+) T-lymphocytes and induce pro-inflammatory intracellular micro-environment marked by increased ILB 920 4353 1401 7412 3383 PMC10876703__F7 TEAD1 promotes the fibroblast-to-myofibroblast transition during TAC or Ang-II-induced pathological cardiac remodelling through the Wnt signalling pathway 7003 23476 54361 1499 PMC10878139__F3 Cross-talk between glucocorticoid receptor and YAP/TAZ signaling pathways 26524 9113 4485 PMC10878139__F5 TGFB signaling pathway mediates the effect of the GR signaling pathway in the TM 7042 4087 4088 4089 PMC10878147__F1 Illustration represents the polyphenols targeting the NFKB pathway associated with Alzheimer's disease 351 7124 114548 PMC10878151__F1 Structure of the SMAD family and overview of TGFB/SMAD and BMP/SMAD signaling pathway 4087 4086 4090 4088 3240 4092 4089 4091 10763 PMC10878151__F2 Crosstalk between TGF‑B/SMAD and other pathways 100507431 4088 2475 3725 4089 4092 4087 PMC10878151__F4 Phosphorylated SMAD2/3 signaling pathways regulate the process of HCC 4087 4088 4089 PMC10878789__F10 Schematic diagram illustrating the occurrence of asthma 114548 8408 79065 PMC10879340__F4 Zebrafish Studies on TGFB Signaling and Pharyngeal Arch Patterning 9464 2625 64388 5396 56033 PMC10879484__F7 Predicted activation of macrophage classical activation signaling pathway in parenteral nutrition piglets 3458 929 7099 54625 5970 406919 10461 6364 3659 7124 1536 2634 4719 5315 PMC10879531__F6 Mechanism of action of Gal-3 in the A-ED through the TLR4/MyD88/NFKB pathway 7099 4615 7124 PMC10880550__F1 Effect of acetylcholine released from cholinergic neuron on heart, visceral smooth muscles and the brain 7223 7224 3785 PMC10880550__F5 Complex interactions among GIRK, TRPC1/4/5 and KCNQ channels with GPCRs via G proteins A or BG subunits and PIP2 in neurons 7200 7223 7224 7220 PMC10882095__F5 Immune molecule interaction network in the blood and heart tissues of chronic Chagas disease (CCC) patients 3627 6352 4283 3458 6347 PMC10883245__F8 DOCK7 in EVs mediates intercellular communication between TAMs and CRC cells 85440 2308 19 PMC10884126__F8 Interaction networks of “pathways-differentially expressed lncRNAs-target genes” 1281 5275 57115 8061 1277 929 404203 51804 84152 256076 25975 PMC10884763__F5 WATME-specific immunotherapy for obesity-induced coronary heart disease (CHD) 114548 3661 7099 255738 PMC10884928__F1 NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota 23475 93100 55191 203447 10135 952 PMC10886007__F2 Mitochondria-dependent apoptosis pathway 596 581 27429 2021 637 PMC10886007__F3 TGFB/SMAD signaling pathway 10220 4087 4088 4086 4090 650 655 652 4092 4089 4091 PMC10886007__F4 AMPK/SIRT1/PGC-1A signaling pathway 9817 847 23411 4899 7019 PMC10886030__F4 Oxidative inactivation of PTEN in insulin-related metabolism and muscle differentiation 1950 5728 2475 PMC10886332__F3 Co-expression network for the PP group based on lncRNA key regulators 1311 25819 100188776 PMC10886574__F2 The SIRT1–c-Myc axis in the control of stem cells 23411 23326 4149 7015 27293 4144 PMC10886582__F3 Pathways related to activation of pyroptosis 114548 22861 79792 PMC10886830__F7 Toll-like receptor (TLR) signaling pathway with a focus on TLR4 7099 7124 4615 7189 PMC10887144__F1 In vitro liver organoid model creation 652 2249 1950 3082 246744 5008 PMC10887283__F2 Therapeutic potential of anti-IL-1 agents in hidradenitis suppurativa 3552 3553 3554 27179 27177 4615 51135 3654 3656 941 9308 2920 6364 3576 2919 PMC10887358__F2 Signaling pathways of B cell receptor (BCR) 974 973 4067 2534 6850 29760 5336 613 27086 933 PMC10888650__F1 Potassium’s (K+) Role in Various Cellular Processes 2821 2597 2885 3479 3480 3667 2353 3725 8772 841 836 355 790 PMC10889827__F1 BMP signaling represents a fundamental signaling profile in periosteal effects 5741 89780 650 654 652 PMC10889827__F2 PDGF signaling mediates periosteal activation and blocks BMP2-induced osteogenesis 650 5159 4086 4090 PMC10889827__F3 Ihh signaling plays a critical role in periosteal bone biology and shows complex interaction with other molecules 650 4086 4090 3549 6608 27148 51684 PMC10889827__F4 Wnt signaling has important indirect as well as direct effects on PDCs 650 4086 4090 3549 2932 7477 1499 324 PMC10891054__F9 PART1/AC007728 25859 401109 8857 PMC10891274__F2 YAP/TAZ in fibroblast-like synovial cells (FLS) and its related signaling pathway involved in RA 7004 7005 7003 8463 PMC10891858__F1 Investigating the Role of Non-Coding RNA in Non-Alcoholic Fatty Liver Disease 2475 355 7038 PMC10892479__F1 NFKB signaling (canonical and non-canonical) pathways 613 4055 5971 5970 PMC10892479__F4 Cytokine storm induced by SARS-CoV-2 proteins (ORF7a, ORF3A, M, and N proteins) mediated by the activation of NF-kB 6356 6363 6361 6370 6364 6366 10850 10344 7124 PMC10893548__F7 NMN promotes hair growth by regulating the paracrine system of cells 1499 367 3553 3383 PMC10895590__F6 Immunorecognition of RNA/DNA fiber NANPs via the cGAS-STING signaling pathway can be regulated through functionalization with aptamers 115004 29110 3661 PMC10896604__F4 Metabolic pathways involved in rectal cancer radioresistance, including significantly upregulated (marked in red) and downregulated (marked in green) abundances of proteins and metabolites in poor responders tumor tissues 3099 2539 2597 3939 26227 2271 6472 6470 6510 2744 PMC10896652__F1 Relationship between NGF/TrKA signaling pathway and KOA peripheral hyperalgesia 4803 283871 7442 PMC10896898__F4 Mixed and gene only representations of the original KEGG pathway 10235 5336 25780 51196 5579 5335 5578 10125 115727 5582 PMC10898159__F2 Regulations in KIT protein and signaling pathway 2247 3815 2261 6608 272 167410 5727 8643 114783 PMC10898168__S1 Inhalable hybrid nanovaccines (NVRBD-MLipo) with virus-biomimetic structure against SARS-CoV-2 infection 941 7099 7124 942 PMC10898204__F5 KLF participates in the pyroptosis process of ulcerative enteritis through positive regulation of TXNIP/NLRP3 pathway 9314 10628 114548 79792 PMC10899349__F1 IGF1/IGF1R axis and its downstream signaling pathway 3479 3480 673 2475 2932 1499 PMC10900617__F8 ZnONPs disrupt lysosome activity and impair autophagic flux to facilitate exosome secretion in keratinocytes and macrophages 114548 7096 7098 PMC10902513__F2 TGFB/Smad signaling pathway involved in radiation skin fibrosis 4092 64750 4089 PMC10903931__F1 Hepatic phospholipid biosynthesis pathways 7038 10400 5662 PMC10904539__F2 AhR in tumor energy metabolism 405 367 3099 29 196 2597 6839 PMC10905894__F4 Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation 7186 100506742 3002 1616 839 8772 840 790 7124 842 637 835 56616 27429 472 4703 8739 PMC10907606__F8 Hypothetical model showing the role of OAT in IPF pathogenesis 4942 5625 4087 4089 4088 PMC10907749__F1 Host immune responses to T. gondii infection 7099 81622 7097 54106 51284 4615 3394 920 PMC10907749__F2 Antagonizing the host immune response by T. gondii 6772 6774 8651 3717 9021 PMC10909944__F9 Mechanistic schematic model of action of circRNA_SLC8A1 in macrophages against Mtb infection 8878 3569 7124 PMC10909982__F5 Wnt/Beta-catenin signaling pathway potentially contributes to PTC progress 1499 324 595 PMC10910240__F7 Mechanism of aerobic exercise combined with canagliflozin therapy against ISO-induced CHFCanagliflozin combined with aerobic exercise therapy modulates protein kinase activity 1543 8854 56603 PMC10910709__F9 Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis 9817 79792 114548 PMC10910758__F1 Simplified diagram of the canonical pathway and alternative pathway of the NFKB signalling pathway (Created with BioRender 7124 7099 4050 958 5971 PMC10910758__F6 Scheme of FOP pathogenesis and the involvement of NFKB signalling 90 100187761 4093 4086 4090 7099 4089 3146 9242 5168 4018 2475 6662 3397 860 PMC10910842__F2 Roles of the kinesin-2, 3, 4 family members in HCC 9928 2113 9371 24137 23095 PMC10911275__F4 FlyBase Pathway Report pages 1956 6010 867 PMC10912430__F4 Signaling pathways that may be triggered by cellular pyroptosis during intestinal I/R 10628 7099 11035 8737 114548 1956 PMC10912471__F1 Notch signaling pathway 3714 182 2273 3516 100188776 PMC10912719__F2 DNPNB pathway 5471 7808 5640 2271 471 10606 5813 5814 158 8833 2717 PMC10914313__F7 The mechanism by which ARM promotes chemoresistance via PPARG/ABCG2 pathway 948 9429 7018 PMC10915131__F6 Working model for the role of the mechanistic target of rapamycin complex 1 (mTORC1) and its regulated macroautophagy in the induction of cardiomyocyte necroptosis by large doses of isoproterenol (ISO) 197259 11035 7942 8737 PMC10915940__F1 Canonical signaling pathway of interferon-gamma 3717 3716 6772 3459 3460 PMC10915952__F3 The crosstalk between the Wnt and bone morphogenetic protein signaling pathways in osteogenesis 2932 324 4086 4090 6010 1499 860 9242 PMC10915960__F1 Preconditioned mesenchymal stem cells with high therapeutic potential in various pathologies 9242 875 847 PMC10917649__SF6 Mapping of the identified gene classes of MetaCyc PWYG-321 mycolate biosynthesis to the KEGG ko00061 fatty acid biosynthesis pathway 2194 355 2242 84869 109703458 51102 3073 54995 1356 PMC10917885__F1 UST treatments specifically target the IL-12/IL-23 signaling pathway 10090 7297 6775 3717 149233 6774 PMC10917928__F1 TCM polysaccharides’ role in regulating tumor innate immune response 7097 4615 7099 7189 10010 929 PMC10917928__F2 TCM polysaccharides’ role in regulating tumor adaptive immune response 613 6850 4117 PMC10917964__F3 Schematic diagram illustrating the promotion of bone formation by incorporating Sr2+ on the surface of titanium-based materials 6668 1499 4318 100187907 4772 PMC10918650__F1 l-isoleucine biosynthetic pathway in E 7067 7068 157739 PMC10918892__F5 Schematic diagram illustrating the role of miR-223-3p on NLRP3 inflammasome signaling pathway in LPS-induced HTR8/SVneo cells 7099 4615 114548 79792 PMC10918910__F1 Mechanisms through which the gut microbiome contributes to oncogenesis 7099 1499 196 1545 1543 1573 5921 PMC10918910__F2 AhR activation by microbiome in the tumor microenvironment 324 196 1545 1543 PMC10920255__F2 Gut bacteria and their metabolites can reach blood vessels, exert local effects in joints, modify macrophage-mediated inflammation and influence GA pain through breaches in the intestinal barrier 7099 4615 114548 PMC10920326__F2 Differential cellular components within the bone marrow microenvironment involved in immune evasion of MM 958 6280 952 2247 929 PMC10920911__F3 Glucose metabolic reprogramming on CRC 2539 6774 10628 3939 PMC10921469__F9 TRPM4 and TRPM5 mediate Na+ influx upon stimulation with bitter compounds and carbachol (acetylcholine) in parietal cells from the cell line HGT-1 as major signaling pathway 717 54795 29850 PMC10925712__F1 Schematic biosynthetic pathways of tocopherol and tocotrienol synthesis 3652 100682260 3258 PMC10925886__F3 Myeloid cell behaviors and functions by the circadian clock 7852 3383 2920 3579 6387 4267 6366 942 PMC10925886__F4 Lymphocyte behaviors and functions by the circadian clock 9575 80790 613 4783 1901 1236 6366 3586 PMC10925900__F7 Amyloid-Beta-Induced Dendritic Spine Elimination Requires Ca2+-Permeable AMPA Receptors, AKAP-Calcineurin-NFAT Signaling, and the NFAT Target Gene Mdm2 4776 4775 718 4193 PMC10928192__F1 TNF/TNFR1 signalling through complex I 7124 8737 8717 7186 23118 PMC10928192__F2 TNF/TNFR1 signalling through complex II 7124 8737 8717 7186 23118 8772 11035 197259 PMC10928192__F3 Interplay between TNF/TNFR1 complex I and complex II signalling pathways 7124 197259 7186 8737 8717 8772 11035 1540 23118 257397 PMC10928970__F1 BRAF gene signaling pathway 3273 1950 1956 369 673 PMC10929826__F8 MUC1 promotes RIF by regulating macrophage ROS-SHP2 signaling pathway to up-regulate inflammatory response and inhibit angiogenesis 4582 3458 29110 2475 3091 PMC10930675__F8 RUNX2 and CXCR4 effects on melanoma cells 7852 860 2475 PMC10931375__F6 miRNAs targeting different components of the WNT signaling pathway to inhibit tumorigenicity 8325 693185 6319 324 1499 11278 PMC10931608__F11 Signaling pathways involving MISP 11339 126353 6774 PMC10931645__F3 Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets 324 634 914 962 3902 2267 11126 4049 151888 51744 10666 10225 201633 PMC10931919__F1 Origins and intracellular sensors of self-nucleic acids promoting the IFN-I signaling pathway 51284 54106 3454 3455 7297 3716 7098 115004 29110 10379 PMC10932085__F1 TRPs modulate inflammation in immune cells 7225 7220 7442 59341 7226 7222 54795 29850 54822 6772 6778 6774 114548 2475 7189 50943 PMC10932085__F2 TRPs modulate anti-inflammation in immune cells 7224 7442 79054 PMC10932467__F2 Possible effects of IL-6 signaling on energy intake and energy expenditure under non-obesogenic conditions 472 6774 7350 PMC10932966__F3 Distribution of S1P is strictly controlled and involved in innate and adaptive immunity 7097 124976 324 920 969 PMC10933033__F1 Adaptor proteins mediating the signaling of TLR receptors 7097 7099 54209 114609 79745 79930 4615 50964 2885 7189 84166 7187 3661 3663 PMC10933033__F2 TOLLIP-mediated regulation of IL-1R signaling 54472 3654 7189 PMC10933033__F3 Pro-inflammatory cytokine expression by interleukin receptors via STAT and IRF transcription factors 6778 6772 3663 3662 958 3661 PMC10933033__F4 Adaptor protein SLAP-2 regulates CSF1R-mediated differentiation and survival of macrophages 1436 9846 2885 PMC10933339__F9 Schematic model of the contributor and potential mechanism of KAL in the occurrence and development of NAFLD 4040 9314 57104 51099 PMC10933439__F1 Canonical Activin-, BMP-, and IFN-mediated signaling pathways 659 92 93 3716 7297 4087 4088 4089 4086 6772 6773 10379 4093 4090 11274 57154 PMC10933445__F6 Model depicting the reciprocal interplay between miR-579-3p and MITF in BRAF-mutant melanoma cells through the modulation of MAPK signaling pathway 673 4286 51663 PMC10934027__F6 Metabolic pathway of terpene biosynthesis 4598 9961 4597 3652 282552 PMC10934612__F3 Gene regulation in fatty acid metabolism pathways by GFIPO compared to WEGG 31 2194 4018 100 847 7038 3991 1149 338 137964 4547 PMC10935121__F8 DEG pathways involved in the sesquiterpene synthesis pathway 4598 4597 3652 PMC10937442__F8 Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT signaling of CD4+ cells 3565 3567 3596 PMC10937455__F1 The intrinsic immune system in the pathogenesis of GN 114548 929 4615 PMC10937592__F3 Mechanism of SCFAs madiate a decrease in cholesterol levels 64240 29881 1581 8213 19 PMC10937592__F4 SCFAs bind with FFAR2, FFAR3 and GPR109A to improve hepatic steatosis, respectively 2867 2865 355 PMC10937645__F8 Proposed model of the recognition of bacteriophage DNA by the animal immune system 54106 4615 3654 51135 7189 3665 29110 3661 115004 PMC10937991__F8 Graphical abstract 3458 3460 3717 PMC10938139__F1 Research progress of periostin and osteoporosis 9242 4041 4040 847 859 649 PMC10938783__F7 Multifaceted mechanism of KTC1101 in anti-tumor therapy and immunomodulation 2475 6352 3627 3458 PMC10939994__F2 Correlation of HDAC7 and three signaling pathways 7474 51564 324 5728 572 4193 6774 PMC10940489__F7 STAT3 influences cardiac fibrosis through multiple pathways 6774 4087 4088 4089 PMC10940631__F3 Compensatory relationship between the ubiquitin‒proteasome pathway and the autolysosome pathway 8408 595 1026 331 PMC10941343__F12 Elucidating the anti-hypertensive mechanisms of Uncaria rhynchophylla-Alisma plantago-aquatica L: an integrated network pharmacology, cluster analysis, and molecular docking approach 9475 1950 1956 1499 4193 5594 6714 7412 PMC10941471__F7 Graphical abstract 4018 4087 4088 PMC10942463__F10 Nucleotide metabolism associated with purine and pyrimidine pathways 3263 4693 6240 3614 7084 PMC10943832__F2 Metabolic pathway of tryptophan (Trp) 23498 8942 125061 1571 PMC10944040__F1 Molecular mechanisms of IL‐1 release 3554 4615 7189 23118 257397 3553 79792 114548 PMC10944040__F3 Antagonism of IL‐1 signaling pathway 3556 51135 4615 3554 7850 PMC10944040__F2 IL‐1 signaling pathway 3556 4615 3553 3554 3654 51135 PMC10944225__F8 Schematic summary of the mechanism of the role of BMP2 and the BMPR/Smad1 signaling pathway in the modulation of CGRP expression and progression of BCP 650 4086 4089 796 PMC10944957__F1 TGFB superfamily signaling pathway and the potential therapeutic targets in pancreatic cancer 26585 4087 4088 4089 4086 4090 PMC10945197__F3 Function and mechanism of exosomes derived from different cells as communication mediators in colorectal cancer metastasis 387 8829 100302142 85495 5728 2833 6387 7852 PMC10945329__F9 ADSCs-Exo pathway reduces pyroptosis and improves tissue regeneration in the liver, which has been injured by ischemia-reperfusion and partial resection 1499 595 7472 7099 114548 79792 PMC10945329__F10 Exosomes generated from human adipose mesenchymal stem cells reduce hepatic fibrosis by suppressing the PI3K/Akt/mTOR signaling pathway and altering choline metabolism 2475 907 56994 PMC10946266__F6 MgH2 protects against APAP-AKI by inhibiting TXNIP/NLRP3/NFKB pathway 572 581 114548 PMC10948547__F1 Molecular mechanisms of TLR4 in osteoporosis development 8451 6935 3146 9682 693215 7099 4615 6285 860 PMC10949727__F2 FOXO3a regulating apoptosis and cell cycle in breast cancer 842 836 581 355 595 PMC10949864__F3 Mechanisms for the extracellular acidification inducing alterations of Ca2+ fluxes 7223 1267 2828 7220 7224 7442 PMC10950698__F9 IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11 6778 3597 6520 23657 8651 PMC10950925__F2 Visualization of the extrinsic and intrinsic apoptosis pathway 355 8772 637 4170 581 331 317 PMC10950953__F5 Cellular interaction of immune cells and stem cells in the jaw 9242 50616 6347 PMC10951359__F6 CGRP-induced anxiety-like behavior through epigenetic regulation of the p-HP1G–KLF11–MAOB–dopamine pathway 3240 8462 4129 PMC10953212__F1 Lipid metabolism in NAFLD 345 948 80339 345275 79143 4018 338 4547 53345 PMC10953212__F4 Relationship between inflammation and NASH disease progression 3716 3717 114548 6774 PMC10957538__F3 Impact of particulate matter (PM) on airway remodelling 3567 3576 2919 920 7474 PMC10957552__F1 Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis 5743 3037 26585 2661 9210 PMC10957566__F2 Protective effect of the Notch signaling pathway on B cells under irradiation exposure 6476 5045 5079 10113 100188776 PMC10957658__F3 COX-2-PGE2 signalling pathway in RCC 6714 6774 5909 PMC10958678__F7 P53 and mut‐p53 in the TME during cancer development 80328 920 9636 PMC10958717__F2 Oxidized lipids and cholesterol affect MSC differentiation 1950 9242 10682 860 PMC10959754__F4 Ubiquitination in TNF signaling 7124 8717 7186 8737 90268 1540 9825 81858 3550 23118 257397 8772 197259 11035 PMC10960420__F12 Patterns of effectiveness of C 3717 6774 50943 PMC10960729__F5 Tumor suppression and promotion of the cGAS–STING signaling pathway 675 115004 3466 PMC10960729__F6 Activation of cGAS–STING signaling pathway in autoimmune diseases, neurological diseases, and visceral inflammations 11277 203228 4397 472 260431 1777 PMC10960729__F2 Triggers of cGAS–STING signaling pathway 10084 115004 4841 PMC10960729__F3 Signal transduction mechanism of cGAS–STING 115004 29110 3661 PMC10960957__F5 Ferrihydrite-mediated methanotrophic nitrogen fixation in paddy soil under hypoxia 1896 1636 3250 2645 PMC10963404__F6 Mode of action of DMXAA and its derivative HHMX in human and mice 115004 4280 3661 29110 3569 PMC10963452__F2 Schematic plots illustrate the signaling mechanism of various adipokines in intervertebral disc cells 3953 387 3717 6774 26060 1240 51094 79602 4615 1499 729 23411 PMC10963452__F3 Schematic plots illustrate the signaling mechanism of various osteokines in intervertebral disc cells 1499 6469 6678 3579 3577 PMC10963904__F3 Metabolic map of the l‐methionine synthesis pathway of E 7067 4118 11113 7054 PMC10963904__F2 Metabolic map of the l‐methionine synthesis pathway of E 4118 11113 7067 2717 PMC10963930__F0 An active form of vitamin D, calcitriol, directly enhances the expression of Rspo2 by binding to the vitamin D receptor (VDR) 7421 8549 4038 4593 5913 340419 PMC10965438__F1 Nanomaterials modulating TAMs for the treatment of GC 1844 6774 594857 9332 942 941 PMC10965438__F13 Nanomaterials modulating TAMs polarization for the treatment of pancreatic cancer 596 594857 1508 7099 9332 PMC10965438__F15 Macrophage membrane-coated nanomaterials and macrophage-based microrobot for the treatment of digestive system tumor 594857 3146 1956 2475 PMC10966608__F4 EcDNA in drug resistance 1956 673 1719 PMC10967197__F10 The role of the IGF2BP2-TRPM2-AS/PABPC1-NUMB-NOTCH1 axis in GBC angiogenesis 101928607 10644 8650 26986 27161 3280 23462 4851 PMC10967338__F2 EGFR wild type and EGFRvIII mutated comparison 1956 1950 7039 685 PMC10967338__F4 IL13RA1/IL4RA JAK-STAT6 pathway, IL13RA2, and single-domain vNAR coupled to IL13RA2 3597 6778 3598 PMC10967436__F7 ROS modulation of the Keap1-Nrf2-ARE signaling pathway 9817 4094 1728 PMC10967781__F1 Functional connections between the IR and IGF-R signaling axis 3481 3479 3480 3482 PMC10967781__F2 Insulin-like Growth Factor-1 Receptor in Tobacco Smoking-Associated Lung Cancer Development 3484 3486 3485 572 596 2475 3481 3479 3488 3489 3480 PMC10968029__F3 Diagrammatic portrayal of GRB2 splicing variants, particularly GRB3-3, in signal transduction 2885 3183 100 PMC10968114__F6 TSG-6 Inhibits the NFKB Signaling Pathway and Promotes the Odontogenic Differentiation of Dental Pulp Stem Cells via CD44 in an Inflammatory Environment 960 860 1834 PMC10968558__F3 Alteration of DNA damage response in the pathogenesis of SCA3 472 545 9656 11284 1111 7157 581 5366 PMC10968836__F2 Comparison of the signalling pathways triggered by TNFR1, Fas and TRAIL agonist receptors 7124 6868 355 8717 7186 8737 PMC10969083__F5 Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways 3908 6543 6547 153 2778 196883 60 1756 1674 5566 487 488 5567 5350 489 6262 4625 4624 4602 7273 7137 2010 4000 7168 7139 781 784 55799 783 785 10369 59283 7169 7124 7170 7045 183 7042 7043 4607 PMC10970237__F5 Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways 7248 7249 1975 1977 PMC10970282__F8 Construction of the potential miRNA-target negative correlation regulatory network involved in the FoxO signaling pathway following G 114907 1514 84676 664 PMC10970410__F12 LncRNAs potentially involved in the immaturity-stemness regulation processes in the human keratinocyte lineage 678655 84848 5966 25805 4091 2252 627 2668 100628315 255480 81029 9314 PMC10970955__F1 Systematic engineering for the de novo biosynthesis of genistein and glycosylated derivatives 5236 55276 355 65057 PMC10971110__F3 Immune response and gene expression through the NF-kB signaling pathway in sepsis 54106 7098 51284 7097 7100 10333 7096 7099 4615 6347 942 941 3929 958 PMC10971231__F2 Pivotal role of the NGF/TrkA signaling pathway in PDAC 4803 2668 7442 9311 627 PMC10971254__F10 Binding of IL-33 to its receptor induces the MyD88/IRAK1/IRAK4/TRAF6/NFKB- dependent signaling pathway and the TRAF6/MAPK/AP-1-dependent signaling pathway 90865 6761 4615 7189 PMC10971338__F1 General schemes of the NAD+ metabolic pathway 203447 93100 10135 23475 952 PMC10973144__F3 Pathological macrophages that promote inflammation or fibrosis have altered metabolism as a results of lung injury 4758 1118 6774 929 7097 PMC10974426__F1 Virus-activated intracellular signaling pathways 3661 115004 3454 3455 3716 7297 6772 10379 3659 PMC10975212__F1 TGFB/SMAD signaling pathway 4087 4088 4092 4089 4086 4090 4091 PMC10975235__F2 Type I IFN signaling 2475 10379 3661 3665 3454 3455 7297 3716 6772 6773 6774 PMC10976354__F2 KEGG enrichment analysis of the SGNI targets 5914 7124 1616 3725 5728 596 581 1636 790 842 637 835 351 472 367 PMC10976710__F4 Molecular connection between the mTOR signaling pathway and polyploid giant cancer cells: (A) The interplay between polyploidy, senescence and mTOR signaling 2475 3569 960 PMC10977403__F2 Dependence receptors have two properties: when the ligand is present, binding to the ligand promotes cell survival, migration or differentiation 5478 2475 3725 331 355 PMC10977574__F7 Core pathway of AP intervened by SHG (PI3K-Akt signaling pathway) 7097 5879 3667 2885 4193 572 6256 PMC10979625__F8 Brief figure summarizes the FGF2-FGFR1-p21 regulatory pathway in FGFR1 amplified ER + BC cells 2260 6774 595 PMC10980228__F6 H. Model for the BCM mode of action 6010 7006 100124696 2242 PMC10980521__F7 Main pathways of reproductive candidate genes for follicular growth and ovulation in Tibetan sheep 652 285704 5069 3485 3479 659 658 3480 3973 4089 4086 4090 2778 1583 6770 PMC10983073__F3 Diagram of the inhibition of TSLP Signaling by HZ-1127 and TEZE 85480 3717 3716 6774 PMC10984535__F6 Pathway dynamics of islets during diabetes progression 885 886 774 3099 2289 2308 5728 2309 8737 4087 PMC10984988__F9 Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells 7124 3934 330 6288 64332 1440 6364 3656 1435 5971 PMC10985098__F3 Skeletal interoception in the aberrant subchondral bone remodeling of OA 4852 23237 181 9242 PMC10985190__F2 Nerves promote tumour cell growth and survival The neural impact on tumors is mediated through sympathetic, parasympathetic, and sensory nerves, as indicated by solid lines in the diagram 1956 154 56339 627 4803 PMC10985261__F12 The VDR-mTOR Signaling Pathway in DKD Development 7421 54541 2475 PMC10985914__F2 Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers 1543 1576 1312 1545 PMC10985960__F10 Hypothesis of possible IFN-I signaling pathway regulatory mechanism based on our findings in PD 4773 10379 7124 PMC10985998__F8 Expression of genes in carbon, ATP, NADPH metabolism in C 2821 2539 6120 7086 2597 4967 PMC10986082__F1 Targeting TFs in CSC from multiple perspectives A Directly blocking the combination of TFs and DNA: mainly through epigenetic mechanisms 7018 6608 1499 960 PMC10987323__F7 MtETC in regulating bacterial infection 3586 114548 717 718 PMC10987773__F4 Hepatic lipid metabolic pathway during pregnancy 3643 5465 338 7038 51129 1581 PMC10987845__F1 Glycan biosynthesis mutants were screened for immune stimulatory properties 941 942 2973 51083 PMC10989355__F2 Regulatory signaling pathways activating Schwann cells (SCs) response in peripheral nerve regeneration (PNR) 1270 627 6714 9780 6663 PMC10990851__F8 Metabolic pathway map of biosynthesis related to photosynthesis 572 2242 5091 PMC10991391__F3 TGFB influences cellular metabolism through canonical and non-canonical pathways 4087 4089 5209 26227 6472 2475 5468 PMC10991391__F5 Cellular metabolism and myofibroblast contraction cascades 6010 5209 26227 6472 4087 4088 4089 2475 PMC10993167__F2 Related regulators of N6‐methyladenosine (m6A), 5‐methylcytosine (m5C) and N7‐methylguanosine (m7G) are involved in the signalling pathways of drug resistance during tumour treatment 3717 6774 9589 57721 54890 3206 4314 4319 PMC10993426__F7 Metabolites, metabolic pathways and related metabolic genes that work in autophagy 145837 9370 6794 2597 23411 PMC10993482__F4 Gal-1- and Gal-3 pathways promoting EMT in fibrosis 4089 4087 4088 1499 PMC10995224__F2 Signaling pathway that was affected by ridaforolimus 27250 7249 2475 23239 23035 5728 64798 PMC10998350__F5 Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway 472 23411 7014 PMC10999489__F2 Personalized treatment concepts in extraocular cancer 2735 51684 2736 6608 PMC10999569__F3 PIAS family in cancer: from basic mechanisms to clinical applications 7124 8554 10401 51588 PMC11000312__F2 Mechanisms underlying SALL4 regulation and function in gastric cancer 57167 1499 2638 2146 7403 3099 960 7045 6774 PMC11000312__F3 Mechanisms underlying SALL4 regulation and function in colorectal cancer 57167 574513 2735 1499 PMC11000312__F4 Mechanisms underlying SALL4 regulation and function in liver cancer 7124 57167 5728 3880 960 4072 619501 PMC11001198__F5 Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue 3569 1950 1956 4089 2056 57817 151176 9518 3077 30061 1356 7037 3263 3240 9332 7018 55652 3162 57192 PMC11002873__F3 Working model for the Wnt, TGFB, and Pax6 signalling in the regulation of ciliary body development 4087 4088 5080 652 4086 4090 4089 51176 8313 4487 4488 PMC11003173__F10 Hypothetical modules and cold response pathways of eggplant 4602 2077 867 PMC11003173__F5 Metabolic pathways of glutathione and expression profile of related genes 26873 2937 2936 PMC11004224__F8 KEGG network diagram of cytokine-cytokine receptor interactionLarge white box: biological pathway map 7124 4049 4050 1271 1896 6846 7173 PMC11006178__F12 Proposed schematic model of METTL14 in TLR4-mediated innate immunity and promoting CSFV replication 57721 51441 7099 PMC11010822__F7 MTA1/mTOR pathway in prostate cancer 9112 2475 595 PMC11011165__F1 Inappropriate STAT activation in cancer cells 1956 6714 613 PMC11012138__F3 Oxygen sensing and HIF pathway activation in embryonic neurogenesis 2056 5080 1747 430 1499 PMC11012558__F4 TRPVs and neural stem cell proliferation 1950 3479 51393 59341 162514 1431 PMC11012798__F2 C and N metabolisms affected by N sources 2444 2597 5183 PMC11016262__F3 Immune cells along the gut-lung axis 90865 64806 8174 PMC11019658__F2 DHM induces apoptosis in tumour cells and induces the associated signalling pathway 355 581 4851 3416 2475 PMC11022384__F3 Metabolic characteristics of microglia 2744 2475 627 PMC11022503__F8 Proposed mechanism of erroneous differentiation of TSPCs under high glucose 3146 860 642658 64102 1277 PMC11023816__F1 Vitamin A metabolic pathway and the enzymes involved in retinoid metabolic flux in human liver 5950 1381 1382 157506 216 80339 51109 8854 1592 1545 56603 9227 PMC11023816__F9 Proposed pathways by which paracrine and autocrine cytokine signaling modulates vitamin A metabolism across stellate cell activation phenotypes 7186 9227 1382 3570 7099 4615 5915 5950 PMC11023972__F4 DDR components regulate NFKB signaling pathways 4615 7189 51284 51311 54106 472 3665 PMC11023972__F5 DDR components regulate JAK-STAT signaling pathways 2237 3454 3455 3716 7297 6772 3717 6773 10379 55215 641 PMC11024162__F9 TGFB signaling pathway 4087 4088 4089 PMC11024365__F9 Proposed modeling of antioxidant mechanisms in H 1312 57716 790 108348016 1879 4602 PMC11024860__F9 Working Model: HDAC6 maintains primordial follicle dormancy 7249 4803 627 10013 7018 PMC11027102__F3 Blockade of the CD47-SIRPA signaling pathway initiates an adaptive immune response to kill tumor cells 115004 140885 961 PMC11028018__F5 Proposed model illustrating the inhibitory effects of GBE on TGFB downstream signaling pathways 1277 4087 4088 PMC11032202__F3 Oncogenes versus tumour suppressor genes in glioblastoma 1956 5290 5728 1029 7157 5925 4609 4763 PMC11033252__F5 Mechanisms of human NLRP3 inflammasome activation and regulation 7124 9294 3554 57506 4615 841 79792 114548 140609 834 PMC11033252__F6 Mechanisms of human NLRP6 inflammasome activation 7124 7099 4049 171389 834 79792 114548 PMC11034122__F6 Comparative physiological, biochemical, metabolomic, and transcriptomic analyses reveal the formation mechanism of heartwood for Acacia melanoxylon 1312 5053 790 PMC11034122__F7 Different pathways activated in A 7504 101448070 6120 790953 4597 PMC11037416__F3 Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages 961 140885 3627 7097 7099 2475 729230 6347 114548 920 PMC11045263__F1 Mechanisms underlying enhanced immunotherapy efficacy through exercise 3601 2833 6373 4283 3002 6713 PMC11045904__F2 Inflammatory signaling pathway involved in AD is depicted in the figure 114548 351 7124 3553 PMC11045904__F3 Intricate relationship between the gut and brain axes in PD is delineated by the schematic signaling pathway, with a focus on the inflammatory cascade triggered by dysbiosis at the gut lumen and BBB 7054 920 7099 PMC11046830__F2 Glycocalyx degradation in LPS or septic conditions 7450 7018 324 7035 PMC11046830__F3 Oxidative stress response in ECs 50507 26073 79400 114548 2242 847 4282 PMC11046830__F4 Cascade of effects resulting from the release of IL-33 under the action of endothelial injury and other factors 90865 6761 7412 920 6346 4353 6774 4313 4318 PMC11046856__F2 Non-canonical Wnt signaling pathways 4920 5879 3725 PMC11046856__F4 Crosstalk between Wnt/Beta-catenin, Notch, and TGFB signaling pathways during wound healing 182 4088 3280 100188776 7422 8313 1277 PMC11046940__F3 Regulation of autophagy to affect radiosensitivity involves a complex network of signaling pathway 6714 6774 5728 3146 472 3717 2475 8408 PMC11048214__F5 IPA canonical pathway analysis in genes containing prioritised variants 581 9049 4282 2053 10845 351 54059 4118 8050 5096 30850 2744 6472 1629 PMC11048239__F1 Flux-independent signaling pathways activated by AMPARs in neurons 4067 627 23237 PMC11048239__F4 Flux-independent signaling by NMDARs in neurons 9722 24145 6714 7442 PMC11048329__F3 Schematic presentation of current evidence on Cx32 association with signaling pathways regulating proliferative and cell death processes 1956 7124 595 6714 8737 11035 197259 2475 3065 PMC11048425__F5 Proposed metabolic routes associated with lipid and Beta-carotene biosynthetic pathways in ΔcarRP WJ11 in comparison with the WJ11 strain 11113 2717 4669 4693 PMC11048686__F1 Vitamin D synthesis pathway 1628 120227 1593 1594 7421 1591 PMC11048799__F5 Mechanism by which GAA promotes muscle development and growth through mirNA-targeted gene regulatory signaling pathway [27,43,44,47,48,49,50,51] 2548 1977 2475 3481 3265 5154 80310 PMC11049059__F8 CCN1-mediated signaling pathway in pregnant women with SARS-CoV-2-infection 3491 2022 7046 5281 PMC11049451__F3 Estrogen biosynthesis pathway from cholesterol to estetrol with the enzymes involved 1583 1586 3284 1588 1576 PMC11049850__F3 Molecular mechanisms of LPS bacterial interaction with dental stem cells 7099 4615 1758 1832 3569 PMC11049926__F4 General model of neuroinflammation in epilepsy 7124 3569 3553 3458 3627 6347 6352 PMC11050207__F5 Significantly altered KEGG pathways in LAPST vs 29984 7408 5728 2534 126669 572 7450 4863 1101 1758 948 1832 PMC11050257__F2 Androgen receptor structure and signaling pathway in PCa 6462 367 6908 7113 PMC11050257__F5 MYC protein and its signaling pathway 4609 4149 2932 324 PMC11050413__F10 Mechanistic map illustrates the role of NDUFA6-DT as a sponge for miR-455-3p in gliomas, disrupting its ability to suppress YWHAH/YWHAG expression 7533 7532 572 100132273 994 995 PMC11053566__F10 Proposed mechanisms of action of eudesmane-type sesquiterpene lactones on the TNF-Alpha-induced NFKB signaling pathway 8717 7186 8737 5970 PMC11053710__F2 Cross-talk of Dyrk1B in signaling pathways in development and disease 2736 5727 2737 6608 3845 2475 6018 9149 PMC11053956__F6 JAK/STAT signaling pathway mapper 7124 8717 8772 1540 2752 2242 7099 27005 7098 81030 3014 4015 5008 197259 637 114548 90865 PMC11054193__F7 DEGs and DMs change following exogenous ABA therapy and UV-B stress in the R 5162 1737 3156 4597 2224 PMC11054859__F5 KEGG pathway (hsa05200 pathway in cancer) 6779 4117 8772 PMC11054859__F6 KEGG pathway (hsa05226 gastric cancer) 324 4089 4583 6469 51426 PMC11055934__F4 illustrates the various components of the p53 regulatory pathway and relevant polymorphisms associated with ISFO 4193 4318 4313 55135 7515 55000 PMC11056518__F3 IL-23 and IL-12 and their receptors, with summary of associated effector cells, cytokines, and immune function 3717 6774 149233 7297 6775 PMC11056704__F8 Graphic illustration for role of oestrogen‐induced exosomal SNHG17‐CCL13‐CCR2‐M2 macrophage axis in ovarian cancer 388796 729230 6357 PMC11058799__F7 Gene network crosstalk between selected DEGs (TYK2, STAT1 and TLR7) created with NetworkAnalyst software [44] 3437 3429 6772 3716 51284 7297 55601 4939 834 PMC11058998__F3 Piezo1 affects the occurrence and development of diseases through multiple signaling pathways 9780 114548 2475 619501 PMC11058998__F4 Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors 90550 26524 9113 5878 4087 4088 2475 PMC11060011__F8 Molecular action schematic 27122 6925 56339 1499 56947 PMC11061161__F3 Amino acid metabolism modulates T cell survival and lineage commitment 7054 2475 920 PMC11061361__F2 LIPUS holds potential as an effective approach to counteract synovial inflammation and fibrosis 114548 3553 1499 595 8878 5315 PMC11062983__F7 pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells 6774 3569 3570 581 PMC11063389__F2 Therapeutic targets and inhibitors targeting JAK2/STAT3 signaling pathway for TNBC treatment 2548 3717 6774 PMC11063913__F1 Regulatory mechanisms of cytokines in male sex determination in mice 6736 2626 7536 2254 268 30812 6662 5730 7490 1761 PMC11063913__F4 Regulatory mechanisms of SOX9 in sex differentiation 6736 2254 6662 PMC11063913__F5 Graphical summary During sex determination in the male embryo, the expression of numerous cytokines at specific times and spaces act together to regulate the lineage differentiation of Sertoli cells 2626 268 7490 7536 6736 2254 6662 1761 5225 PMC11064393__F1 CGAS-STING signaling pathway 115004 29110 3661 PMC11065696__F7 Mechanistic scheme of UBB in ccRCC 1788 7314 6667 7422 PMC11065698__F1 5-LO-dependent oxylipin formation from ARA, EPA and DHA 4048 4056 4258 4050 PMC11076692__F1 Genes and mechanisms of sex determination 2626 84733 2018 56956 7490 7026 6736 2516 6662 2263 2254 1761 6663 1499 668 PMC11076696__F2 GLP-1RAs in protecting endothelial cell function 7124 3383 7412 PMC11076710__F9 Nrf2/ARE signaling pathway, mitochondrial ROS, and NLRP3 inflammasome in renal tubular epithelial cells under high lipid conditions 9817 1728 114548 PMC11077374__F5 FOXM1 in regulating Wnt/Beta-catenin signaling pathway and autophagy in pancreatic cancer 729082 2305 1499 PMC11077380__F3 Antitumor application of Se-AAs 4087 129521 6741 100507436 4277 596 80328 PMC11079208__F3 HER-2/EGFR signaling pathway in breast cancer 1956 4087 4088 4089 PMC11079208__F5 Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies 3569 6774 5728 2191 654 8434 7078 7168 27250 PMC11079285__F2 TREM2, as an oncogene, promotes the progression of PTC, GC, PRAD, RCC, EAC, and BCC by activating the PI3K/Akt, NFKB, and JAK/STAT3 signaling pathways, respectively 54209 6850 6774 2638 PMC11083345__F5 DEGs and DEPs involved in Alpha-linolenic acid metabolism, terpenoid biosynthesis and phenylalanine metabolism pathway 4015 4149 10654 4597 PMC11083431__F6 Possible gene expression changes from enhanced NRF2 signaling and depleted NOTCH signaling in the bile acid synthetic pathway from cholesterol in Keap1F/F::RbpjF/F::AlbCre liver at 3 W of age 4899 1581 1593 9420 4097 1582 8647 PMC11083511__F1 Subsets and functions of CD4+ T cells 2625 3662 196 920 50943 604 PMC11083695__F1 Canonical hedgehog signaling pathway acts after the hedgehog (HH) ligands join the Patched-1 (PTCH-1) to release Smoothened (SMO) and enhance the translocation of glioma-associated oncogene (GLI) into the nucleus 6608 51684 2294 3234 PMC11083695__F2 Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma 6010 55872 6608 2475 2735 2736 1499 PMC11084201__F18 Mechanisms of MPs’ impacts on the liver 355 7038 4099 4280 55364 3952 PMC11084272__F7 Action of multifunctional FYD in preventing cancer metastasis 7412 3383 7124 6935 4313 2335 1000 1499 PMC11084446__F8 Brief diagram of the proposed therapeutic effect of the LiESWT in improving detrusor hyperactivity via TRPV channels and the cellular signaling pathway involved in regulating intracellular Ca2+ oscillation in a rat model of OHD-induced DHIC 7442 59341 387 PMC11084561__F3 Two consecutive signals are requisite for inflammasome activation 114548 9447 79792 PMC11084589__F4 Possible targeting pathway of ABA in PD 55915 7099 4615 10645 PMC11085123__F1 Biosynthetic pathway of terpenoids (A), alkaloids (B), and phenylpropanoids (C) in plants 4598 9961 3423 3652 340451 PMC11085166__F2 Keap1-Nrf2 signalling pathway for gene expression control 9817 847 1728 5444 4353 PMC11085255__F3 Effects of natural products targeting Nrf2-related signaling pathway on myocardial ischemia 114548 23411 22933 PMC11085419__F5 Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation 1956 3949 7454 2309 6927 255738 PMC11087094__F4 Three greatly important metabolic pathways in digestive system tumors 6715 3294 2752 283871 189 1584 1585 3291 1431 5091 PMC11087106__F7 High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NFKB and PI3K/AKT/mTOR signaling pathways in rats 7124 581 2475 PMC11087724__F1 AMPK/mTOR signaling pathway involved in regulation of feed intake in chickens (created with BioRender 7248 7249 6009 2475 PMC11087724__F3 Detailed leptin signaling pathway in the hypothalamus of chickens (adapted from “Cytokine Signaling through the JAK-STAT Pathway”, by BioRender 3717 6774 9021 4852 PMC11087971__F4 The ECM-receptor interaction pathway and (B) the IL-17 signaling pathway 960 7450 255743 1101 1758 948 1832 961 920 8772 23118 257397 84818 7186 9618 6280 6274 3934 6278 7038 4314 4318 4322 7189 PMC11088339__F2 The transforming growth factor B (TGFB) signaling pathway in cardiac fibrosisTGFB regulate phenotypes of the cells through activation of mothers against decapentaplegic (SMAD)-related pathway together with p38 pathway 140805 4087 4088 4089 PMC11088339__F5 Therapeutic application of adipose-derived stromal vascular fraction in myocardial infarction 7189 6347 729230 4087 4088 2475 PMC11089157__F3 Transcriptional regulation of FOXK2 1950 1956 6662 3607 406987 693187 PMC11089204__F5 Proposed metabolic pathway of psilocybin and its active metabolite psilocin 54575 54600 4280 1565 PMC11095605__F2 Activation and inhibition of the Wnt/Beta-catenin signaling pathway 1499 6425 10788 92162 PMC11097647__F6 B cell receptor signaling pathway-enriched Module_01 7784 81793 5099 89857 1606 773 8851 3274 3384 100 930 933 5777 640 63951 51301 85442 91010 974 1143 PMC11098157__F1 Metabolic pathway for S‐warfarin 1559 54658 1576 873 PMC11099600__F4 KEGG Pathway Analysis of ultravist-treated mast cells 7124 2887 64798 6009 6010 2475 6502 220441 6520 201163 2932 7975 5728 PMC11101339__F4 KRAS pathway and KRAS inhibitors 3845 5900 2475 PMC11103679__F1 Direct and indirect mechanisms of androgen signalling 367 6714 7018 PMC11106741__F2 Esc, a compound with potential anticancer properties, promotes apoptosis and inhibits the proliferation of tumor cells 3479 9817 6774 2475 3716 3717 1499 6667 595 3178 PMC11116266__F2 JAK STAT signaling proteins in spondyloarthropathy and possible mechanisms of action of the JAK inhibitors 2056 3458 7173 PMC11117599__F1 Anti-fibrosis and fibrogenesis mechanisms of NO/NOS system 4088 4087 4089 PMC11117599__F2 Anti-fibrosis mechanisms of CO 50507 4088 4087 4089 114548 PMC11117599__F4 Anti-fibrosis mechanisms of H2 in fibrotic diseases 4088 4087 6778 114548 4089 2475 847 PMC11117611__F3 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases 4734 23327 5728 3480 3479 5962 PMC11117611__F4 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases 4609 4734 23327 7528 PMC11117611__F5 NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases 4734 23327 5728 9113 10253 6774 2475 PMC11117676__F2 The nuclear signaling pathway of RIP-mediated EpCAM 4072 23621 51176 2274 PMC11117695__F9 MAs protect IPEC-1 cells from H2O2-induced oxidative stress, inflammation and tight junction protein disruption via activating the Nrf2 pathway to inhibit the ROS/NLRP3/IL-1B signaling pathway 2810 114548 1728 7124 PMC11117976__F3 NETosis in neutrophils 7097 3579 10628 PMC11117976__F8 Immune suppression during bacterial infection 771 57716 10628 114548 PMC11118972__F5 Effect of pteF deletion on cell metabolism 4018 11113 4118 PMC11119514__F1 RDNVs reverse osteoporosis by potentiating osteogenic differentiation of hBMSCs via targeting estrogen receptor A (ERA) signaling 650 4086 4090 860 PMC11119800__F2 OGT is required for the development of infectious liver diseases 2475 8473 10724 PMC11119800__F4 OGT has dual effects on liver fibrosis 8473 6722 7032 PMC11120013__F2 Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer 1839 1950 1356 9817 1728 847 PMC11120279__S1 FDT vaccine with the ability to activate systemic immunity for tumor inhibition 324 920 10461 3456 PMC11120609__F1 Metabolic pathway of cyclophosphamide 1555 1559 1557 1576 PMC11121022__F1 Systemic sclerosis, recognized as a prototypical autoimmune disease, is intricately governed by a myriad of autoimmune mechanisms 7292 7297 324 920 919 3119 3592 PMC11121248__F7 Two separate mechanisms for the role of MerTK and ENG in TNBC progression 4609 10461 2022 PMC11121563__F1 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review 627 693152 118788 6362 51564 1540 57214 6367 2475 1277 5728 PMC11121563__F2 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review 100313781 693160 3977 2012 5728 693167 2309 PMC11121563__F3 Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review 106144539 283131 378938 5728 283422 2475 PMC11124330__F17 This study 6280 6279 7099 4615 2921 6374 PMC11125669__F1 Pattern recognition receptors (PRRs) involved in intracellular viral sensing and downstream signaling 115004 57506 29110 51284 54106 4615 3665 3661 3663 10379 6772 6773 PMC11125855__F1 Intracellular DNA sensors involved in the activation of IFN signaling and the NFKB pathway 51428 3181 3661 1660 57506 29110 54106 4615 51135 3654 7189 7187 170506 3665 23210 7124 PMC11126050__F7 KIT structure and signalling 3815 2475 7083 7084 PMC11126125__F4 Immune response induced by DTMUV infection and its immune evasion 2522 22954 81844 57506 29110 3661 PMC11126959__F2 Biosynthesis of O-GlcNAc 2821 2673 55577 51005 7054 64841 5238 10724 PMC11130833__F1 Molecular activity of BTK- and BCL2- inhibitors in CLL 613 4067 6850 5336 695 29760 2475 581 596 PMC11130840__F1 PCP-mediated signaling pathway in Drosophila and mouse 9620 1951 1952 57216 81839 22881 1855 1857 1856 7481 PMC11130926__F1 Bacterial Q de novo and salvage pathways 84267 81890 79691 PMC11147929__F6 LSS affects endothelial cell pyroptosis through IKKE/STAT1/NLRP3 signaling pathway 4047 6772 79792 3606 114548 834 PMC11148314__F4 Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging 10097 4001 115004 PMC11170970__F6 SH alleviates DSS‐induced colitis via the “SH‐gut microbiota‐5HIAA‐AhR axis 4280 196 3553 3569 PMC11171322__F8 Graphical overview of representative exclusively differentially expressed genes from our RNA sequencing data in the myeloid and lymphoid group that are clearly assigned to the BMP/TGFB signaling pathway 7124 7040 8326 100507588 2931 8772 11213 3381 4982 6423 55504 3654 4488 1284 1296 1298 PMC11171594__F1 TLR-mediated signaling 3146 7097 7096 10333 7099 7100 81793 4615 51135 3654 7189 51311 54106 51284 3663 3665 114609 7098 3661 PMC11171836__F11 Mechanism by which Pin1 regulates NAFLD 5300 1374 2194 PMC11172187__F1 Gliogenic switch during brain development 4774 6662 3280 2670 PMC11172217__F10 FGF5 promoting secondary hair follicle growth 3082 581 27123 147111 2250 2260 54894 1499 51176 7454 PMC11172514__F1 The mechanism regulating NLRP3 inflammasome activation in canonical, non-canonical, and alternate pathway 4615 3654 51135 7189 23118 114548 79792 8772 841 140609 834 PMC11172598__F1 Gene interaction network map of each group 8854 777 11162 22944 PMC11172960__F1 Signaling pathways in psoriasis pathogenesis in keratinocytes 3716 3717 6772 84818 7297 8717 7186 6774 4283 3627 6373 6279 6278 3872 5743 6364 3383 3569 7412 PMC11172960__F2 Putative molecular targets and their associated signaling pathways for psoriasis in keratinocytes 51592 2171 7415 2444 114548 9447 6774 1843 196 23411 3146 PMC11172960__F4 Molecular targets of natural product-derived compounds for psoriasis treatment 23411 6774 6772 114548 5970 6364 1052 6502 PMC11172987__F2 Host Cell Death and Modulation of Immune Response against Mycobacterium tuberculosis Infection 3454 3455 3716 7297 6772 6773 10379 PMC11173086__F9 Proposed regulatory network of bulbil initiation in P 7018 54861 4015 108348016 30062 PMC11174581__F1 Promotion mechanisms of microecologics on sports performance 1325 7480 7039 7350 23411 PMC11174684__F5 Schematic representation of the hypothetical signaling pathway activated under PEG-6000 treatment in Saragolla and Svevo cultivars 2077 5597 7018 4602 PMC11174690__F3 Fas/Fasl signaling pathway by active ingredients in goji berries 3929 355 8772 836 PMC11174690__F5 SIRT signaling pathway by active ingredients in goji berries 1374 7019 355 23411 4899 23410 2308 PMC11174998__F1 One-carbon metabolism 1719 4552 4397 635 4524 572 875 PMC11175075__F1 Jasmonic Acid on Stress Response and Quality Formation in Vegetable Crops and Their Underlying Molecular Mechanisms 4015 4609 4602 PMC11177111__F0 miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL 595 1499 100302259 3155 PMC11177995__F8 Schematic diagram for the mechanism underlying the apoVs-mediated rescue of the impaired OVX MSCs biological function and their capacity to improve osteoporosis 406937 4041 4040 7048 324 1499 PMC11185840__F3 Activation of the complement system and its functions 718 717 727 114548 4179 1509 55054 729 730 735 1514 2475 PMC11185840__F4 Sphingolipids and complement components signaling in glioblastoma 1901 124976 3717 6774 23786 6935 51645 114548 1514 7852 PMC11186353__F3 Illustration representing the sites of action of different polyphenols in asthma pathway 90865 64806 85480 920 PMC11186359__F8 Schematic diagram showing how PM increases AREG-dependent glutamine metabolism and lung cancer proliferation 374 1956 6510 2475 PMC11186432__F4 Different regulatory functions of F-box proteins in gastric cancer 387 55294 7419 54461 9113 25827 2305 26234 79791 23014 27250 80204 5728 26232 1000 PMC11187367__F6 Summary of the findings 5624 972 3579 960 4282 7124 3606 54360 9332 2662 6387 221044 PMC11192764__F1 TGFB complex and TGFBR signaling pathways 7939 7046 4087 4088 PMC11192909__F0 Mechanism of NGR1 in alleviating colitis 4041 4040 324 1499 8549 PMC11194209__F1 Major abnormal signaling pathways in TNBC 1956 4855 4851 8324 4040 1950 4041 126669 2885 5728 2475 324 PMC11195429__F1 cGAS-STING and cell death pathways 581 836 840 11035 197259 842 81030 29110 3661 115004 7124 79792 834 114548 PMC11195429__F3 Antitumor therapies awake the cGAS-STING signaling to accelerate the antitumor immunity 842 115004 6573 4283 3627 PMC11200706__F2 Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes 1499 4286 7306 1638 PMC11200741__F1 Canonical pathway (WNT/Beta-catenin pathway) 4041 4040 2932 324 1499 51176 PMC11201201__F2 VEGFR activation by the VEGF family of growth factors and resulting downstream signaling pathways to angiogenesis and lymphangiogenesis 5281 7422 7423 7424 2475 PMC11201617__F1 Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview 1950 3082 1956 2002 PMC11201619__F2 Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model 9817 2946 6622 PMC11201634__F2 Wnt/Beta-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment 4041 4040 2932 324 1499 PMC11201817__F2 The influence of curcumin on mammalian DHA synthesis pathway and its neuroprotective effect [61] 9415 627 3569 7124 PMC11201820__F1 Relevant pathways and their targeted inhibitors (in red) for the EC 284 2022 7422 1950 1956 5728 2475 PMC11201820__F2 Interaction between activated ECs and pericytes/vascular smooth-muscle cells (vSMCs) and their targeted inhibitors in red 2022 2475 7422 1950 1956 5728 5155 PMC11202056__F8 STRING pathway analysis depicting protein–protein interaction (PPI) networks 64581 388325 9476 342667 64221 130120 283748 203111 3624 93649 203100 391723 250 64063 80332 5158 4887 56934 283953 84636 10563 83715 4342 PMC11202427__F1 BMP pathway in cardiomyocyte differentiation 4086 4090 4089 3670 PMC11202427__F2 WNT signaling pathway 2932 1499 324 PMC11203016__F10 Illustration of the Toll-like receptor signaling and apoptosis pathways in M 54472 114609 929 100187907 1356 5447 6955 790 828 6769 472 PMC11203611__F4 Diagram of endocannabinoid biosynthesis and mode of action of the endocannabinoid system within a neuron 222236 2166 7442 PMC11203986__F6 CAF-1-associated pathway 3065 25842 7290 5111 PMC11203986__F7 HIRA-associated pathway 7290 4609 3838 PMC11203986__F10 DAXX-associated pathway 1616 9869 6839 546 PMC11204528__F8 Dicerandrol C Suppresses Proliferation and Induces Apoptosis of HepG2 and Hela Cancer Cells by Inhibiting Wnt/Beta-Catenin Signaling Pathway 4041 4040 2932 1499 51176 PMC11205484__F2 Biosynthetic Pathways of Protectins and Maresins in Macrophages and MaR-2 in Brown Adipose Tissue Activation 59352 54209 729230 3240 1690 PMC11206024__F3 TLR4 signaling pathway 114609 4615 7189 7187 29110 3661 PMC11206339__F1 Common synthesis pathway for testosterone from cholesterol and its subsequent conversion into estrogenic and androgenic active metabolites 1583 1586 3283 6715 3293 1588 PMC11206395__F3 Therapeutic mechanism of polyphenols for anxiety disorder 3589 627 847 PMC11206589__F1 Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies 1956 3480 2194 581 PMC11211753__F6 Possible mechanisms of action of TR for altering ECM turnover 4092 4087 4088 4089 5340 PMC11223907__F1 Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics 1557 1576 1559 PMC11225869__F1 In alveolar general capillary endothelial (gCap) cells, IGFBP7 prevents FBXW2-dependent ubiquitination and degradation of NFKB1/2 3490 26190 4790 PMC11240502__F2 Tryptophan metabolites interact with AhR and potentially interfere with serotonin and melatonin synthesis 15 196 1543 1544 1545 438 PMC11240772__F1 Active Canonical Wnt/Beta-Catenin Signaling Pathway 4041 4040 324 1499 PMC11240772__F2 Inactive Canonical Wnt/Beta-Catenin Signaling Pathway 1499 4041 4040 324 PMC11241178__F8 Target pathway analysis of cordycepin combined with doxorubicin against breast cancer 8717 7124 841 836 6885 4790 83737 8837 6347 2919 3726 4318 4314 3383 PMC11241191__F7 Schematic illustration of SRI regulating apoptosis in HCC 6717 6774 596 619501 PMC11241496__F2 Targeted therapies in RAS-RAF-MAPK pathway 1956 5979 3845 5728 2475 PMC11241496__F3 Targeted therapies in the vascular endothelial growth factor (VEGF) pathway 7423 5281 7422 7424 5728 2475 8205 558 PMC11241568__F2 The JAK–STAT Pathway in Childhood B-Cell Acute Lymphoblastic Leukemia 3716 3718 6772 6774 64109 85480 3717 PMC11247318__F1 Action in lymphoma 930 695 4067 6850 940 3458 7124 PMC11247557__F9 Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T‐cell lymphoma via TLR4 signaling pathway 7185 330 8837 331 596 7099 114548 79792 PMC11252768__F8 Working summary of the study 3156 6608 51684 2735 PMC11257078__F1 Species differences in bile acid synthesis 1581 1582 1593 PMC11257964__F1 Molecular machinery of apoptosis, pyroptosis, and necroptosis 355 8717 8772 58484 8737 7186 114548 637 581 11035 197259 79792 PMC11257964__F4 Targeting PANoptosis for cancer therapy 11035 8737 81030 8772 114548 1687 197259 79792 PMC11262449__F1 Genes involved in glucose sensing, the reward system, sweet taste receptors, the endocannabinoid system, and insulin mediated glucose uptake found to have SNP associations with dietary sugar intake and/or cardiometabolic risk factors in children 3643 3667 8660 PMC11265800__F6 Signaling pathways in melanoma cells and tissue 411 51363 1464 4313 PMC11274024__F6 Different cellular events in RG7388-resistant CLL samples 1643 1026 64782 23612 4193 64393 5111 10973 7508 55332 8793 94241 355 581 27113 8795 PMC11274073__F11 Therapeutic Potential of Dalbergia pinnata (Lour.) Prain Essential Oil in Alzheimer’s Disease: EEG Signal Analysis In Vivo, SH-SY5Y Cell Model In Vitro, and Network Pharmacology 3717 6774 3569 3570 7297 6775 6772 6778 PMC11274312__F6 PPI network of the DEGs in immune-related pathways 27040 3702 939 3932 5551 2833 5473 29851 6775 940 917 3002 920 925 30009 5133 1493 915 916 PMC11274515__F1 Signaling cascades of autophagy in hepatocellular carcinoma cells (HCCs) 1956 5728 8408 619501 PMC11275100__F1 PARPi effect in cancer cells and immune cells 672 675 115004 PMC11275360__F4 lncRNA regulates adipocyte differentiation through TGFB/BMPs/Smad signaling pathway 10220 285958 655 652 PMC11276560__F5 DEGs in selenium metabolic pathways of KEGG metabolic pathway map 1491 6401 867 PMC11276702__F7 Gene expression of plant hormone biosynthesis pathway in the intraspecific hybrid fruit of H 6476 8205 1610 4015 84890 PMC11276752__F1 Deciphering Drug Resistance: Investigating the Emerging Role of Hyaluronan Metabolism and Signaling and Tumor Extracellular Matrix in Cancer Chemotherapy 960 7358 6010 80146 3037 594842 3036 3038 PMC11277918__F2 cGAS-STING can transform a cold tumor into a hot tumor and promote tumor cell apoptosis 3586 3569 7039 3553 115004 PMC11278074__F1 Therapeutic approaches to vascular Ehlers–Danlos syndrome 4318 545 6714 367 PMC11278853__F1 Schematic illustration depicting the potential anti-inflammatory effects of hypolipidemic agents primarily targeting LDL-C reduction 114548 3156 7412 47 3383 255738 7422 PMC11278853__F2 Emerging evidence regarding the anti-cancer features of novel lipid-lowering treatments, including CETP inhibitors, bempedoic acid, and PCSK9 inhibitors 1071 8313 595 255738 331 581 47 PMC11278952__F3 Alterations of bile acids involved in the synthesis pathway in HD 1581 1593 10858 1582 9420 51302 25801 PMC11279831__F1 IL-36 signaling pathway 920 130340 27179 79092 12 6348 PMC11279976__F2 Common metabolic pathways of NAD+ and NMN 93100 349565 64802 23057 23475 130013 952 203447 10135 4837 PMC11280316__F8 Suggested schematic illustration of the mechanism by which crocin could induce cell survival and exert anti-oxidative and anti-inflammatory effects in stressed cardiomyocytes 23531 581 7099 4615 5728 9817 2475 2152 1728 PMC11280978__F1 Mechanism of action by which MNPs cause neurotoxicity 1786 7472 627 PMC11281655__F2 RIG-I-like receptor signaling pathway in antiviral immunity 29110 57506 3661 3665 23476 PMC11281666__F9 Deoxynivalenol and Its Acetylated Derivatives on Lipid Metabolism in Human Normal Hepatocytes 10400 5091 3931 100137049 10162 10908 11145 56261 10434 PMC11284857__F3 Disturbance of DFC signaling pathways results in disorders of osteoclast differentiation 7092 7048 4488 PMC11284857__F4 Depicted regions primarily reside within the dental follicle tissue surrounding the root apex 7480 5727 4089 7048 PMC11287639__F1 SMAD4 in the transforming growth factor-beta (TGFB) signalling pathway 650 652 657 27302 659 92 93 4090 4086 4093 7046 7048 PMC11292300__F2 WNT signaling pathway in CMTC 324 8312 1499 2932 4609 595 PMC11292615__F0 This review seeks to offer a comprehensive look at how salidroside impacts gut microbiota and its potential therapeutic role in treating atherosclerosis 7099 4853 2475 4615 114548 PMC11294427__F3 The S100A9‐receptor for advanced glycation end products (RAGE) signalling pathway in cardiovascular disease 6280 650 860 PMC11302569__F3 Four key mechanisms of gut microbiome associated with the occurrence and progression of colorectal cancer a 351 1235 920 3082 PMC11307123__F6 Mechanism of diabetes promoting myocardial fibrosis via AMP-activated protein kinase (AMPK)/enhancer of zeste homolog 2 (EZH2)/peroxisome proliferator-activated receptor G (PPARG) signaling pathway 8726 2146 23512 PMC11310285__F1 Hypoxia signaling pathway 3091 7428 7018 PMC11311387__F4 Involvement of p53 in cell stress responses and glycosylation-related pathways and the relationship between p53 glycosylation and cancer progression 957 2517 57103 PMC11311808__F2 Genetic and Signalling pathway dysregulation in AC 1499 324 4771 4092 4485 4088 4089 4087 26524 9113 PMC11312684__F1 GSH synthesis and transport of precursor amino acids: (a) Gamma-Glutamyl cycle of GSH synthesis 23657 960 6520 6510 2744 8140 6509 PMC11312736__F7 Glycolysis/gluconeogenesis, pentose phosphate pathway, photosynthesis and sucrose and starch metabolism in zygotic embryos of Yucatan green dwarf and Mexican Pacific tall cultivars 2821 2597 5132 PMC11313175__F2 RNA methylation in the development of muscle and fat in livestock 4616 4208 3716 7038 3717 6774 10682 PMC11313179__F7 Illustration of the most significant regulated target genes related to PPAR signaling pathway 440503 5465 4023 PMC11313500__F2 Molecular pathway mechanisms of cytokines and chemokines associated with inflammation for the progression of pulmonary hypertension 4087 4088 4615 PMC11313706__F6 Regulatory mechanism of bone injuries induced by fluoride 596 1277 2260 4322 4318 650 655 PMC11314424__F3 Diagram summarizing the effects of salidroside (SAL) on cellular signaling pathways 654 650 655 4087 PMC11315658__F5 Synergism between TMEM16A and EGFR in mediating the proliferation of tumors 595 6774 2885 1956 PMC11316721__F1 Molecular mechanisms of RBP4 in insulin resistance 3667 64220 7097 7099 3717 4615 PMC11316721__F2 Molecular mechanisms of RBP4 in pancreatic Beta-cell function 5950 64220 3717 6772 PMC11317487__F0 Graphical abstract and proposed pathway of rhMFGE8 administration attenuate hippocampal injury by improving neurogenesis in SAH models 4240 2475 3208 595 1641 PMC11324288__F1 SLC44A2 mediates the VSMC phenotypic switch in aortic aneurysm 7939 3690 8829 57153 4088 4087 59 6876 9314 861 PMC11326265__F7 The effect of miR-1 loss on glycolytic and pentose phosphate enzymes and intermediates 2539 9563 2821 5226 5725 226 2597 2023 9123 5166 PMC11332896__F2 Signaling pathways involved in muscle atrophy during cachexia 3569 3480 3479 4087 4088 2475 PMC11343602__F8 Schematic diagram illustrating the mechanism and intervention strategies of the IL-27/Blimp-1 axis in regulating Tim-3 expression on Tregs 6772 6774 201633 PMC11347096__F3 Cholesterol metabolism is necessary to defend against foreign antigens 930 613 10410 19 695 4615 6850 6714 2475 3156 9619 PMC11347096__F4 Sphingolipid metabolism 1674 6611 64781 PMC11351413__F2 Biosynthetic pathway of cordycepin 5813 5814 100 132 PMC11351712__F7 Graphical abstract 5727 581 6608 6469 2735 3014 PMC11352233__F7 HER2/epidermal growth factor receptor (EGFR) signalling pathway in breast cancer 4087 1956 4088 4089 PMC11352355__F2 Cell functions of K6, K16, and K17 1956 6772 6774 3458 50616 3868 326 3151 3014 2475 PMC11352841__F1 Bacterial induced mastitis via activating TLR2/TLR4/NFKB signaling pathways in mammary gland cells 7097 7099 4615 3654 51135 7186 7187 7189 PMC11352841__F2 Bioactive compounds targeting NFKB signaling pathway to prevent inflammatory changes and mastitis 7097 7099 4615 7186 3654 51135 7187 7189 PMC11352841__F3 Probiotic targetingTLR2/TLR4 /NFKB signaling pathway to prevent inflammatory changes and mastitis 7097 7099 4615 3654 51135 7186 7187 7189 PMC11352994__F7 Schematic overview of the B7-H4-mediated signalling pathway in trophoblast cells in patients with early-onset PE 4827 6774 595 PMC11353016__F2 Molecular drivers regulating hair follicle fate specification and the initiation of its growth 10913 1499 51176 26281 6469 7042 5154 PMC11354542__F6 Neurotrophin-signaling pathways in the high-intensity exercise group (blue: downregulation) 126669 1610 6955 PMC11354572__F1 Serum TLR2 and TLR9 in Prostate Cancer Patients in Relation to EBV Status 7097 4615 51284 7098 54106 57506 115004 3661 3665 9447 3428 PMC11354688__F5 Process of human steroidogenesis 6770 1583 1586 3294 3292 3284 1584 3291 3290 1588 PMC11354764__F2 Main pathways involved in the development of insulin resistance 5728 2885 3667 4615 2888 7249 6009 3725 PMC11354767__F6 GPR30 signaling pathway 6714 1839 2885 1956 6774 PMC11354818__F14 Integrative Analyses Reveal the Physiological and Molecular Role of Prohexadione Calcium in Regulating Salt Tolerance in Rice 1544 1571 1576 PMC11354872__F2 Short chain fatty acids (SCFAs) and antioxidant roles against CRC development 717 718 9817 847 114548 PMC11355043__F1 Current model of the blood coagulation cascade, depicting NOACs’ mechanism of action 7035 5340 324 PMC11355545__F8 Schematic depicting the signaling pathway ROS/PARP/TRPM2 that causes SiNPs-induced lung inflammation in mice 4280 7226 8505 8878 PMC11356816__F9 Interactions between BAs and Other Viruses 8213 7099 246744 PMC11356930__F2 MEHTCMPs on the signaling pathway of TLRs 10333 7099 5669 929 7097 4615 3654 7189 PMC11356930__F4 MEHTCMPs on the NLRP3 signaling pathway 7099 4615 140609 114548 PMC11357158__F2 TGFB1/Smad pathway mediated by identified ncRNAs 7939 4087 4092 11167 4088 7044 101805488 4089 51174 1277 PMC11360082__F2 Catechol estrogens synthesis pathway in humans and the possible homologs identified in schistosome species 3293 3292 1543 1544 1576 1545 PMC11361845__F5 Analysis of changes in the proteome and phosphoproteome according to DNK72 treatment in patient derived glioblastoma cells 7157 10763 6010 51083 120892 PMC11361850__F3 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) regulate the immune response 4615 7099 5728 114548 3663 2081 3654 7189 PMC11361850__F5 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) regulates apoptosis and autophagy 581 5728 27250 2475 23476 5602 2247 7189 10014 PMC11361850__F6 Mechanism by which mesenchymal stem cells-derived exosomes (MSCs-Exos) promotes axonal growth and neuronal regeneration 114548 868 867 4803 8091 4087 PMC11364386__F1 Blockade of secretory vesicle biogenesis provides a therapeutic strategy for targeting cancer 27032 27333 64083 5329 5328 PMC7615304__F4 Germline and somatic mutations associated with primary aldosteronism 4158 476 3762 2767 9218 1584 1585 8912 3973 1499 1808 PMC7616045__F1 Serine synthesis pathway, folate cycle and methionine cycle 26227 29968 5723 1719 PMC10911341__F9 Potential mechanisms of inhibiting Perk-ATF4-P21 pathway to enhance the efficacy of MPPAlpha-PDT 468 9474 83939 PMC10140933__F12 Pathways of protein synthesis and transport activated by CsRALF34 overexpression (based on the KEGG signal pathway database) 100187907 10985 6845 PMC10459989__F5 Schematic diagram of the plant hormone signal transduction pathway and its correlation with DEGs in response to B 2077 578 10682 6193 6187 PMC10468808__F2 Activation of NFKB and MAPK signaling pathways regulates the expression of catabolic factors 7186 7189 7124 PMC10491753__F5 Pictorial model of intracellular redox balance facilitated by compartmentalization of amino acid biosynthesis enzymes within optimally sized peroxisomes 2820 619537 2819 PMC10607693__F5 Fatty acid biosynthesis and TAG assembly pathway reconstruction 84803 137964 8694 84649 84680 150763 4938 355 PMC10706216__F16 Activation of UPR signaling pathways during ER-stress, caused by TAA injections, in liver cells 7186 581 468 PMC10745682__F2 Potential association between the ER stress signaling pathway and obesity 83939 22926 3667 7494 468 PMC10816037__F1 Different signaling pathways affected by the probiotic strains with anti-obesity or anti-diabetic properties in C 51 9798 207 5465 PMC10837142__F6 Common symbiosis signalling pathway in T 79902 55746 5810 PMC10861954__F3 Unfolded Protein Response 468 83939 22926 PMC10886137__F6 Fatty acid degradation-related pathways of filefish upon Cd exposure 1376 65057 3033 1891 PMC10956371__F1 UPR signaling pathway 22926 83939 7494 468 PMC10966134__F8 Schematic illustrating the proposed mechanism by which the PERK pathway modulates autophagy during RACK1‐mediated neuroprotection after TBI 83939 468 10399 9474 PMC10985007__F1 HIFs and NRF2, adaptive response systems to variable oxygen availability 8453 7428 9978 8452 8454 PMC11022384__F4 Metabolic interactions between tumor cells and GAMs 5230 2820 3091 PMC11056900__F2 Endoplasmic reticulum dysfunction modulates chronic liver disease 7494 22926 83939 3553 468 PMC11074996__F1 The multi-modular engineering and efflux strategies for lycopene synthesis in Saccharomyces cerevisiae 2078 3652 3422 PMC11079205__F3 GLP-1 effects on bone 9846 355 860 PMC11216939__F2 Interplay between the PI3K/AKT pathway and circadian rhythm regulators 5163 9575 406 1628 PMC11276987__F4 Unfolded protein response signaling with their regulating microRNAs 22926 83939 7186 7494 468 PMC11280061__F7 Auxin-regulated TFRN attenuates ABA transport, conjugation and signaling 10006 2878 2241 51225 23261 PMC11354764__F3 Three main UPR pathways induced by ER stress 3667 83939 468 22926 PMC11231459__F2 Tumor progression targeting PDGFR-B signaling pathway, contributed to the pathogenesis of DFSP (created with Biorender.com) 5155 5728 6773 6772 2475 1277 PMC11231459__F5 Understanding of FGFs/FGFR signaling pathway in pathogenesis of DFSP (created with Biorender.com) 2260 2263 10818 2885 PMC11395329__F6 MiR-27a-5p functions in hDPCs 5970 11167 7099 4615 3654 51135 7189 23118 10454 PMC11395544__F9 Oral Administration of Probiotic Bifidobacterium breve Ameliorates Tonic–Clonic Seizure in a Pentylenetetrazole-Induced Kindling Mouse Model via Integrin-Linked Kinase Signaling 3611 836 1499 4280 PMC11396105__F10 Interaction network of lipid metabolism-associated pathways and key genes 5290 1954 3655 122970 10965 570 55902 5443 3490 1376 81616 948 7971 2173 3486 8694 3488 5601 32 2168 2170 84649 PMC11396105__F11 Schematic diagram reveals key genes and pathways involved in the heterosis formation of EFT 335 338 7422 319 1954 355 376497 10999 11001 2257 6720 3690 3691 570 81616 31 32 9415 8694 50486 5443 2295 3488 3490 3487 PMC11373554__F5 MetaCore pathway analysis of the coexpression gene network involving KDM1A in pancreatic cancer 324 619501 5328 545 472 6010 1499 998 5906 5879 999 PMC11373554__F6 Expression of the KDM5A signaling pathway in pancreatic cancer (MetaCore) 2668 5979 545 3082 472 672 23429 7054 23626 1019 PMC11373554__F7 MetaCore enrichment pathway analysis of genes coexpressed with KDM5B in pancreatic cancer 6469 1956 2305 1499 221937 108348019 79960 619501 387 79800 7015 351 8538 6925 27086 23426 6996 3066 PMC11375557__F1 Mechanisms of Epithelial-Mesenchymal Transition 1000 1950 999 PMC11375557__F2 Transcription Factors and Signaling Pathways in the Process of EMT 1950 4585 4680 56648 3694 4323 10123 1977 2064 689 6667 1869 6781 2627 6935 2305 9839 11278 9314 6662 2303 58495 7490 6286 10112 3717 6774 PMC11383172__F2 IBT induced downstream upregulation of the TNFA pathway in human neutrophils 4049 8717 7186 7185 7187 10454 8772 83737 197259 841 843 840 836 3659 6352 6347 6364 1435 8809 355 3553 3569 64127 3383 5743 2919 2921 2920 1437 182 3600 3976 7128 9021 6401 6374 3627 PMC11392669__F10 Tumoral VISTA facilitation of the proliferation of CML cells and suppression of apoptosis 2885 9846 1399 1398 3717 2475 572 596 PMC11395143__F2 Nrg1/ErbB signaling 2064 2065 3084 2885 2475 PMC11395599__F4 Illustration of NETs, ROS, cancer mitochondrial oxidative damage and altered glucose metabolism, including the Warburg effect and glucose metabolic reprogramming, in human cancers is shown 2539 26227 29968 5723 4522 10797 2744 PMC11397228__F4 Impact of BPs on metabolic disease treatment via gut microbiota modulation 8213 7099 4615 5697 9965 7038 2194 PMC11245093__F4 Genomics-based reconstruction of pathways involved in the utilization of monosaccharide derivatives 4284 2444 5226 6120 4668 PMC11333789__F6 Effect of rotenone on regulating the Nrf2 signaling pathway and induction of Parkinson’s disease was proposed 140805 2242 627 PMC11364484__F2 TGFB and BMP receptors and their signaling pathways 4087 4088 92 94 659 657 658 4090 4086 4089 3397 3398 PMC11373551__F8 Identification of core regulatory genes and construction of partial correlation interaction networks related to taurine metabolism pathways 2919 6351 972 5743 29102 324 7538 351 931 3932 10488 3507 958 2534 3495 PMC11375541__F10 Dual functionality of necroptosis in CC patients 3717 7422 4283 3627 6373 3002 10563 915 PMC11375560__F4 LOX activity in promoting tumour progression in breast cancer 4015 649 6714 1398 6774 PMC11379068__F8 The interaction between the PERK/ATF4 branch of endoplasmic reticulum stress response and mitochondrial one-carbon metabolism after ICH 10797 468 8011 6472 PMC11379071__F8 Diagram illustrating the underlying molecular mechanism identified in the present study 56339 26524 51441 23019 29968 10413 468 PMC11379076__F2 MTORC1/2 signaling pathways 5728 5163 8408 9706 9776 7248 7249 6009 64223 64798 PMC11379076__F3 Interaction between mTOR pathway and HCC 3972 174 7248 7249 7528 47 8408 7852 4609 6513 619501 PMC11380518__F3 Biosynthesis of the IPP and DMAPP via the MVA pathway (purple) and MEP pathway (green) 4598 4597 3652 PMC11383167__F1 Biomarker validation in AGS 10379 6772 6773 3429 9636 91543 6614 PMC11387119__F3 Inflammasome sensors have diverse roles in tumorigenesis 114548 171389 9447 58484 4583 6774 920 PMC11387120__F3 Drug resistance mechanism of tumor immune microenvironment factors 6367 3091 6355 3716 6774 PMC11387478__F0 HIRI is a thorny problem after liver surgery such as liver transplantation 2621 10461 5743 PMC11392660__F3 Immunologic mechanisms following decellularized matrix transplantation involve several crucial steps 54106 4615 2475 5728 PMC11392662__F8 Domperidone, a Dopamine Receptor D2 Antagonist, Induces Apoptosis by Inhibiting the ERK/STAT3-Mediated Pathway in Human Colon Cancer HCT116 Cells 1813 3717 6774 PMC11393980__F8 Other targets of pVHL in ccRCC and SNC hemangioblastomas 22882 51460 29110 3717 55893 8877 PMC11393989__F1 Molecular and cellular mechanisms of TGFB signaling pathway in GO 4041 4040 387 4092 8322 6662 1855 4087 4088 4089 50507 PMC11394240__F1 YAP/TAZ mechanisms in solid tumors, particularly HCCs, in hypoxic environments 619501 4485 60485 4018 6010 26524 9113 PMC11394240__F3 Phosphorylation of YAP/TAZ under hypoxic conditions 4018 3156 26524 9113 6010 4485 60485 6477 3480 332 PMC11394487__F2 Mitochondrial biogenesis pathways 4117 7019 7018 23082 PMC11394487__F5 AMPK signaling pathway 6786 23216 6794 92335 1158 64223 57521 2475 7248 7249 1978 8408 3156 1080 3989 2194 29904 3172 1938 595 1376 PMC11394487__F6 ERK/MAPK signaling pathway 1399 1398 6464 5747 2889 6714 2185 8844 5829 1793 673 8649 4342 369 1844 7444 572 6195 1978 1977 6722 2353 2099 5468 6772 2002 4772 PMC11394487__F7 PI3K/AKT signaling pathway 3987 2885 5728 3611 2549 9846 6464 5170 117145 11140 4170 7248 4846 4217 5894 572 1027 7249 4193 2810 9479 7531 1026 6009 596 7157 2475 1978 79923 595 1499 1977 PMC11394629__F1 Genetics of BCC 6608 51684 2735 6469 PMC11394629__F2 Action of Hedgehog Pathway Inhibitors 6469 6608 51684 2735 PMC11394644__F1 NAD+ biosynthesis pathways 125061 339855 8942 93100 10135 23498 23475 952 4837 PMC11394644__F2 Reaction schemes for NAD+-consuming enzymes 952 23411 51548 23410 22933 23409 4837 PMC11394644__F3 Summary reaction schemes depicting the influence NAD+ biosynthesis pathway reactions on the tumor microenvironment (TME) 93100 10135 54956 23057 4837 PMC11395051__F7 The results and the proposed mechanisms of action of the examined proteins and signaling pathways in HEC-1A cells 1524 1950 1956 6774 64321 7077 7076 4313 4318 6648 3569 3977 3976 650 PMC11395074__F3 miRNAs play a pivotal role in maintaining the delicate balance between cell survival and death by modulating the activity of key pathways such as PI3K/AKT/mTOR, MAPK, TGFB, Wnt/Beta-catenin, and JAK/STAT 2064 3082 1950 100302137 2475 5662 3716 3717 6774 324 5090 10746 27250 1499 PMC11395074__F4 Schematic representation highlights how miRNAs involved in the metastatic process through modulation of key molecular pathways such as TGFB, PI3K/AKT, Wnt/Beta-catenin, JNK/STAT, and Hippo/YAP, which are vital for cancer cell invasion and migration 619501 574492 100126296 4087 3838 1399 6667 9112 3084 1500 55290 4851 3732 2064 1499 6659 4088 4092 5728 100126333 150094 27123 9612 85407 8313 6774 3569 5054 10746 8703 6093 PMC11395144__F2 Application of nanotechnology in breast cancer and PMA treatment targeting TRPA1 inhibition 8989 10267 27035 2475 23209 PMC11395144__F3 Application of nanotechnology in MS and KOA treatment targeting TRPA1 inhibition 4397 6588 8989 2670 10645 23411 PMC11395325__F7 Proposed mechanism by which HAE improves lactation 5728 355 7248 64798 PMC11395567__F2 Simplified illustration of the signalling pathway depicting priming and activation of the NLRP3 inflammasome 4615 8717 8772 3654 51135 79184 114548 140609 79792 PMC11395697__F3 Serrated neoplasia routes 4255 3845 4292 673 PMC11395697__F7 Gut microbiome–host interactions in colorectal cancer development 7097 7099 4615 PMC11395697__F8 Tumor–immune interactions and the dynamic interplay between tumor killing and immunosuppressive mechanisms 324 6348 5551 7422 6347 10344 6356 6354 6352 6369 1950 4312 1508 1509 2247 4803 1431 4318 5008 3082 383 PMC11396780__F9 Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism of Protopanaxadiol Triphenylphosphate Derivative in Non-Small-Cell Lung Cancer 2261 51548 23410 6513 3098 5223 3939 9123 1956 2475 4553 4141 8565 PMC11396801__F1 Selection of Reference Genes in Siraitia siamensis and Expression Patterns of Genes Involved in Mogrosides Biosynthesis 4598 4597 2717 PMC11397273__F4 Ubiquitination- and de-ubiquitination-regulating components related to milk fat synthesis 4023 6048 31 2180 2194 2170 6319 8694 79594 51160 PMC11397273__F5 Model for the promotion of milk fat synthesis in dairy cow mammary cells through the ubiquitination pathway by soysterols and myristic acid 948 2475 2194 8694 PMC11397714__F2 IL-1B signaling pathway activates NFKB and MAPKs through the IL-1 receptor, leading to the transcription of genes involved in inflammation and immune responses (Created with https://www 54472 4615 3654 7189 23118 10454 PMC11397714__F3 IFN signaling activates the JAK-STAT pathway, leading to the transcription of genes involved in the immune response (Created with https://www 56832 3454 3455 7297 3716 6772 6773 163702 3459 3460 3717 8660 3667 10379 PMC11398426__F7 Regulation of STING expression by CBFB/RUNXIn basal conditions, CBFB acts as a rheostat to fine-tune cGAS-STING pathway activity 115004 7428 29110 3661 PMC11410975__F0 ALKBH5 activated JAK2/STAT3 signaling pathway and mediated m6A demethylation on Stat3 mRNA, but not Jak2 mRNA, resulting in the phosphorylation and nuclear translocation of STAT3, which enhances the transcription of hypertrophic genes (e 54890 3717 6774 4878 4879 PMC11411235__F2 Functions of tetraspanins in GC 10103 7103 6302 10098 10867 1956 4316 PMC11411235__F3 Functions of tetraspanins in liver cancer 23555 6302 1019 7103 10098 10103 8038 999 7102 2932 4318 PMC11411235__F4 Functions of tetraspanins in PC 10103 60343 7103 54790 6774 6714 7424 7102 4318 4322 PMC11411235__F5 Functions of tetraspanins in CRC 10867 10103 7103 10098 23554 7105 PMC11411607__F3 Canonical and non-canonical NFKB signaling pathways by andrographolide 7124 613 5970 5971 PMC11413889__F9 MetaCore pathway analysis of Schlafen 5 (SLFN5) co-expressed genes in COAD patients from TCGA 6770 5906 920 7852 260431 6347 831 4860 8743 PMC11414392__F11 RUNX1-MUC13 regulatory mechanisms in CRC metastasis 861 56667 8313 595 PMC11414529__F2 Injury induced by histone methylation disorders in diabetic nephropathy affect the major effector cells of the kidney 2146 4851 7403 7071 1786 1602 4916 5080 7490 6422 1499 56998 2145 220930 4088 3164 22943 6347 5054 55553 6868 28996 80335 10365 PMC11419411__F2 Molecular mechanisms and pathways associated with PCa bone metastasis cells (By Figdraw) 1020 7124 8325 6352 4150 3845 6774 1499 6909 4089 10410 PMC11430608__F1 Mechanism of development of AP 7124 3569 6774 PMC11430608__F3 Activated intracellular signaling pathways in acute pancreatitis and their inhibition by natural compounds 3717 7099 4615 9817 197259 6774 PMC11430655__F1 Interaction network constructed for genes involved in central carbon metabolism in cancer (hsa05230) limited to Homo sapiens (https://genemania 7025 171425 5313 8900 2027 5315 3945 387712 5223 2026 5224 864 861 177 23657 8140 3939 682 860 6576 55556 5163 57546 55066 6520 54704 1293 56301 3910 10003 PMC11430655__F2 Graph representing the interaction network of AGER (the gene encoding RAGE) with genes encoding RAGE ligands 829 4790 830 5970 51135 6275 1956 3146 8550 6439 177 1580 6285 3689 6271 6532 6283 3684 6279 1729 PMC11430655__F4 Graph representing the interaction network of Diaph1 with proteins involved in cytoskeletal dynamics 6242 6285 6283 177 2066 3146 1730 1729 387 345456 6778 5970 5216 389 85464 1072 5217 7408 60 54961 58 54434 23002 3984 5311 PMC11430655__F5 Graph representing the interaction networks of selected genes 3910 8263 1293 27164 4162 346171 126823 1788 10155 865 89932 1786 1789 8900 22838 2026 2023 29947 23657 2475 10003 3070 5163 5166 6520 8140 5164 5313 2027 7025 PMC11430996__F4 Effect of anthocyanin on initiating apoptosis in human colon cancer line 355 637 581 572 PMC11431580__F2 Schematic presentation of the interaction between estrogen receptor (ER) and the PI3K/AKT/mTOR pathway 1263 983 1017 1021 1019 2475 PMC11431580__F4 PI3K (phosphatidylinositide 3-kinases)/PTEN (phosphatase and tensin homolog gene)/Akt pathway 367 5163 5728 2475 PMC11432004__F3 Pathways associated with O-GlcNAcylation, thrombosis, inflammation, and cancer 5728 2475 7039 1956 2064 1950 4254 2885 2323 2322 3082 595 1019 PMC11432004__F4 PI3K/Akt/mTOR signaling pathway by O-GlcNAcylation 8660 3667 5163 5728 8473 7249 2194 PMC11432203__F7 Causality of CD4+ TEM markers and PTB and COVID-19 infection based on MR analysis (by Figdraw 2 2634 920 3902 PMC11434717__F3 Terpene trilactone biosynthetic pathway 4598 4597 3423 3652 PMC11434829__F1 Simplified overview of the omega-6 and omega-3 PUFAs metabolism, focusing on the AA metabolic pathway components with relevance in CF 4513 4056 4048 PMC11435552__F2 DBV and GTV suppressing the IFN antiviral system by NS sequestration of key signaling molecules into IBs or FSs 6772 29110 3665 6773 7706 57506 3661 PMC11436262__F3 PPM1G-associated signaling pathways 5496 7248 7249 3397 PMC11436262__F4 PPM1G participates in the occurrence and development of hepatocellular carcinoma and liver fibrosis via different pathways 6428 11060 3280 4854 3276 841 PMC11447943__F2 Main interactions of TRPC5 channel with signaling proteins in a cellular context 84876 7224 9615 9368 9351 6786 PMC11449287__F12 D2O on expression levels of cellular genes involved in “TNF signaling pathway” and “p53 signaling pathway” 7124 7975 1019 1017 472 581 4609 4193 84883 1537 8544 7249 5728 PMC11450209__F3 Exploring kinase-substrate interactions of proteins using KiNet 5058 572 207 10000 6093 5594 5580 6548 1432 5595 7272 673 9475 5562 79923 1915 1917 5566 5605 6195 6446 5604 1956 3643 2549 5770 3667 23178 65018 7046 5894 6885 5599 8844 5063 5062 4659 9113 6714 4609 56924 7071 3717 PMC11450209__F4 Exploring kinase-substrate interactions in functional contexts, such as pathways and shared domains using KiNet 8550 7054 5053 5594 5805 6197 7166 121278 10298 5566 1719 9261 5595 9252 6697 2643 815 5593 818 5592 816 1457 5562 9759 28996 3066 3065 1956 2869 6714 8841 55869 9734 10013 120892 10014 6885 51564 25 817 25865 2932 2011 5587 1020 814 5747 23235 5563 5585 9212 5580 23683 8536 PMC11451039__F2 Modulating mechanisms of the Ang/Tie signaling pathway 1003 387 5879 6714 2308 572 3383 7412 PMC11452178__F9 The regulation of muscle phenotypes by MSTNDel73C mutation with FGF5 knockout 2660 8061 4654 389827 101929726 PMC11453023__F7 TLR-activating and the induced signaling pathway 7100 7099 51135 114609 4615 3654 3656 7189 23118 257397 7187 3661 51311 7186 51284 7098 3665 54106 PMC11455816__F8 Schematic of MAGL blockade-mediated protection from GC-induced bone homeostasis imbalance 1499 860 4023 PMC11456611__F2 The diverse signaling cascades implicated in colorectal carcinogenesis 3481 2064 2066 8660 2885 324 2194 2475 572 1499 8312 4193 472 7046 6608 7048 4485 51684 4087 4088 8772 26524 9113 2735 4089 2736 836 4609 6932 PMC11459742__F4 Modeling ncRNA interactions with signalling pathways using GO data 115004 406905 4615 1956 29110 3661 PMC11460135__F8 Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway 3227 150696 581 2879 PMC11461658__F3 Tryptophan-kynurenine metabolic pathway 8942 8564 23498 130013 23475 PMC11462682__F2 Hexosamine biosynthesis pathway and cardiac function 4976 10724 8473 PMC11464522__F1 Ferroptosis 7018 23657 6520 2182 55240 10162 8031 2879 PMC11464522__F2 Molecular mechanism of ferroptosis in RCC 7018 55240 9601 468 100506392 9447 23657 6520 2182 9817 10162 91039 8031 23417 1803 2879 10365 8462 8473 PMC11464522__F3 Molecular mechanism of ferroptosis in PCa 3191 3458 7018 6772 26227 23657 6520 1666 57214 3710 2182 5925 1786 55240 10162 7942 8031 2879 10110 6665 26 2475 PMC11464522__F4 Molecular mechanism of ferroptosis in BCa 7018 26227 5094 2012 5468 3309 9589 23657 6520 2182 23768 55240 10162 8031 2879 5093 114294 23761 3315 30815 PMC11464892__F7 IL-17 signaling pathway in CD 138 + MM cells 920 8772 351 84818 7054 29761 23118 257397 7124 6278 4314 4318 132014 PMC11465581__F8 The effect of neuroinvasion on immune tolerance in NSCLC NGF released from NSCLC cells induces neuronal cell differentiation and axonogenesis in the tumor microenvironment (TME) 3352 4803 2475 PMC11465851__F3 Pattern recognition receptors on ependymal cells are involved in inflammatory signaling The TLR4/MyD88/NFKB signaling pathway induces the release of inflammatory cytokines like IL-1B and TNFA, while promoting phagocytic apoptosis 929 7099 4615 54106 2302 7124 PMC11466420__F8 Graphical overview of the effect of BA treatment on porcine oocyte maturation 9817 6647 847 6648 2876 PMC11466965__F4 HO-1 may be involved in diabetic cardiomyopathy by regulating various signaling pathways 114548 2879 581 4087 847 PMC11466965__F6 Signaling pathway of HO-1 in the protection of diabetic nephropathy 7124 2182 114548 847 2879 PMC11467144__F5 EGF signalling pathways in the intestinal crypt and potential therapeutic targets 1839 1950 90865 PMC11467144__F7 Summary Chart 1950 8549 3981 23452 4326 657 9314 90865 PMC11468005__F1 PI3K/AKT/ mTOR signaling pathway 5728 7248 7249 PMC11468018__F5 Proposed signaling pathway illustrating effects of cancer and inflammation in the kidney 4615 6935 7189 3654 4087 4088 4089 8717 7186 PMC11474142__F3 Major signaling pathways associated with ENPP1 115004 3240 1869 581 596 PMC11475022__F6 GSEA of 18 patients with CTEPH from the GEO database 1063 2017 11064 9126 85464 23365 2990 7054 230 324 51330 11190 10844 84890 7204 5311 10682 8621 8455 1278 4363 4118 134429 25836 3157 9415 2274 1535 594 5805 226 6611 6834 6389 1384 10884 34 644 26330 1376 10940 3418 64960 7417 1737 PMC11475559__F3 RhoA is overexpressed in cancer and promotes cancer progression via RhoA/ROCK2 signaling pathway 387 9475 595 PMC11475825__F2 Actin mechanism of the NRF2 signaling pathway 8452 122953 2879 2729 2730 6647 54658 10058 3569 3091 654 4851 79923 6657 9314 PMC11475825__F4 IPA analysis of the signaling networks between AhR signaling and NRF2 signaling 196 2033 405 1026 1543 1544 PMC11476647__F1 Nrf2/Keap1/ARE signaling pathway 9817 8452 5978 55290 4553 PMC11476647__F2 Pathways influencing Nrf2 build-up and its downstream pathways 5728 192111 9817 2539 2638 PMC11478363__F5 Research Progress on the Mechanisms of Protocatechuic Acid in the Treatment of Cognitive Impairment 4615 6416 5604 6772 23411 581 596 842 836 PMC11480102__F11 Implications of ITCH-mediated ubiquitination of SIX1 on CDC27-cyclinB1 signaling in nasopharyngeal carcinoma 6495 83737 996 891 PMC11480210__F2 14–3-3 proteins in MAPK, PI3K/AKT, TGFB/Smad, Wnt/Beta-Catenin and Hippo/YAP signaling pathway 7124 3725 5163 261734 324 1499 581 PMC11480210__F3 14-3-3 proteins in the TNFR signaling pathway 5495 581 7124 7186 8717 7185 2475 2002 PMC11480210__F4 14-3-3 proteins in bone biology 1280 176 1311 PMC11481463__F1 Critical role of IET as a drug precursor and the metabolic pathways relating to IET biosynthesis in S 6886 128 7300 PMC11481580__F7 Transcriptome sequencing analysis of overexpressed SikCDPK1 in tobacco reveals mechanisms of cold stress response 4117 54903 578 5901 4609 PMC11481725__F1 Protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure 4842 26291 4086 4090 PMC11481725__F2 Protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure 4318 4313 4087 4088 1958 26291 PMC11482718__F10 Graphic summary of potential signaling pathway involved in MG-induced lipotoxicity in vitro and in vivo 4280 7038 2194 3156 2739 PMC11482726__F10 Working model for NONO positively regulating IRF3-mediated IFNB signaling pathway by detection of PRRSV N 4841 3661 57506 29110 PMC11484033__F6 Lats-IN-1 protects cardiac function and promotes regeneration after myocardial infarction by targeting the hippo pathway 4485 26524 9113 PMC11484321__F7 Distinct methylome profile of cfDNA in AMI patients reveals significant alteration in cAMP signaling pathway genes regulating cardiac muscle contraction 7434 115 2867 2693 6548 55799 10369 6262 3371 845 3270 7074 5058 PMC11484340__F3 Cross-inhibition between the PI3K/AKT/mTOR and RAF/MEK/ERK pathways 5728 5163 7248 7249 4193 572 PMC11484394__F2 Diagram illustrating the regulation of the p53 pathway by miRNAs in prostate cancer (WP3982) 100616323 693129 100302270 472 11200 407019 841 637 5366 63970 581 27113 7157 64393 6477 64065 407037 100616330 143686 192668 842 836 317 5728 2475 3479 406958 406979 4193 PMC11484773__F2 Schematic diagram illustrating the interaction between neuroinflammation and microglial activation, as well as a separate schematic diagram depicting the TREM2 signaling pathway 102 6868 54209 7124 6850 PMC11486635__F3 Apoptosis by IRFs 3454 3455 3459 3460 3716 7297 3717 6772 6773 8772 3661 3659 3665 29110 7187 7186 57506 7189 581 90268 637 317 3662 PMC11486635__F5 IRFs Respond to TLR Signaling and Participate in the Expression and Function of IFNs 56832 3454 3455 3459 3460 163702 114609 3716 7297 3717 4615 6772 6773 7187 29110 3665 3661 10379 121260 3662 51135 80231 3663 7189 3659 3654 3394 3660 3627 PMC11487499__F2 SPOCK1 promotes cancer occurrence by inducing the PI3K/Akt signaling pathway (by Figdraw) 26227 29968 468 4553 PMC11487528__F2 COL10A1 regulates EMT, tumor cell proliferation and metastasis by phosphorylating Smad in conjunction with DDR2 and activating the TGFB signaling pathway 1300 4921 4313 4318 999 1000 6662 PMC11487528__F3 COL10A1 activates signaling pathways and regulates gene expression 1300 4921 1000 999 56339 PMC11487528__F4 COL10A1 in malignant tumors 999 1000 7472 2335 5034 4087 4921 1300 2191 494333 51176 6662 56339 55000 7447 PMC11488446__F2 Alterations in the WNT/PCP Signalling Pathway During the Progression of OA 23002 387 81839 57216 1855 1857 1856 5879 23513 24147 1951 9620 PMC11489006__F1 Hippo signaling pathway 4485 26524 9113 PMC11489006__F2 Upstream regulators of Hippo signaling pathway in CRC 26524 9113 4151 79923 PMC11489333__F8 Positive feedback for self-driving of NK-92AFR-CAR-CXCR3A cells based on IFNG and TNFA synergistically induced high CXCL10 expression 3627 3459 6772 PMC11490128__F7 Schematic model delineating the mechanisms of SEC14L3 in ccRCC 4790 266629 6188 PMC11490609__F4 MAPK pathway activation in zccs1703 7422 2885 3791 6654 10818 2260 4763 673 595 1019 1021 PMC11491057__F2 Tumor immune efficacy by the cGAS-STING pathway 324 941 942 PMC11491057__F3 Epigenetic modulation and tumor immune efficacy 2146 958 941 942 6352 6932 4609 30009 3105 PMC11491057__F4 Illustrates the mechanisms of metabolic regulation in tumor immune evasion 961 3845 4609 948 PMC11491146__F7 Molecular mechanisms by which CCN2 regulates the activity of TRPV4 channels under mechanical stimulation in fibrochondrocytes 1490 59341 6662 PMC11491369__F3 Mitochondria in embryonic heart development 51024 4976 9927 55669 65018 PMC11491690__F1 HOXA9/MEIS1 and FBXO22 promotion of KMT2A‐r acute leukemia 571 2305 4297 3205 4211 1499 PMC11491726__F2 Relationship of class I HDACs and NOXs in CVDs 3458 9817 6772 50507 27035 79400 8841 3066 3065 PMC11491976__F2 PI3K and PIP2-mediated pathway 5105 367 2475 PMC11491976__F3 PI3K/AKT/mTOR signaling pathway 3667 6009 1956 3480 1950 PMC11492689__F1 Roles of non-coding RNAs (ncRNAs) in host response to PRRSV infection 9332 977 51284 7098 57506 3661 29110 7297 9021 8651 6773 6774 51135 3665 6772 10379 6727 5879 7124 1656 PMC11492689__F2 Roles of ncRNAs in host response to PRRSV infection 3455 3665 3659 10000 10346 PMC11492922__F3 Enriched KEGG terms and PPI network highlight upregulated genes involved in immune response and inflammation 3667 613 930 51083 6009 7249 672 1537 5934 572 4602 4193 5728 4513 998 3820 10850 51330 969 3937 11314 3570 2791 5054 1282 5270 3918 29887 PMC11493653__F3 LncRNAs in main phases of diabetic wound healing 378938 6772 4240 6774 60674 283120 114548 100124700 79667 3091 7422 PMC11495063__F4 Metabolic pathways enriched by DEGs between the EPG and PPG 130589 9562 3651 6389 5091 6390 84532 84693 3073 4758 PMC11495891__F6 Application of EVs in circulatory system injury 140885 790 9242 961 PMC11495891__F9 Application of EVs in the digestive system 831 355 4151 PMC11496054__F1 CGAS–STING pathway of cytosolic DNA sensing 115004 29110 3661 PMC11496054__F2 CGAS-STING signaling in female reproductive system diseases 8841 5426 115004 57558 9869 10155 29110 3661 PMC11496173__F4 Molecular mechanisms of Keap1-dependent and Keap1-independent modulation of Nrf2 8452 9817 1738 4094 PMC11496173__F5 Probable mechanism of action of ISL on the Nrf2 pathway 23411 9817 114548 3550 1728 PMC11497390__F7 Rosmarinic acid promotes cartilage regeneration through Sox9 induction via NFKB pathway inhibition in mouse osteoarthritis progression 3553 6662 4314 4322 4513 1280 176 PMC11497461__F1 Graphical representation of imatinib metabolism and transport 5243 9429 1576 6580 613 25 3815 1577 1558 1543 1544 1559 1557 1565 PMC11498046__F4 Preparation of PGRsEV-siYTHDF1 140885 961 3458 54915 8324 1499 8205 PMC11500076__F1 STING signaling pathway 115004 29110 3661 PMC11500076__F2 STING signaling in dendritic cells (DCs) 115004 940 3661 PMC11500330__F3 Radiation-induced skin fibrosis and OS 4087 4088 4089 50507 6667 PMC11502356__F6 Insulin signaling pathway and the shortlisted key mRNA markers 6774 6714 472 5728 7099 3662 639 4193 2475 4609 2932 596 2308 PMC11502381__F2 Bidirectional regulation of the cGAS-STING pathway and immune cells in the tumor immunosuppression microenvironment (A) The cGAS-STING pathway inhibits M2 macrophage polarization and promotes anti-tumor immunity 7942 942 6774 115004 6347 6354 4843 729230 6778 50943 4088 920 PMC11502721__F3 Intestinal stem cells (ISCs) by glucose, fatty acid, and ketone body metabolism 1374 3099 51660 2194 3158 PMC11502721__F2 Intestinal homeostasis by microenvironment 1950 3084 284654 84870 7040 4326 1499 196 6774 84649 PMC11502746__F6 Selected impacts of MGO exposure in SH-SY5Y cells 5211 3421 3420 2026 4724 7381 4701 4710 51004 513 1329 9817 7296 3162 2730 PMC11502918__F1 Various stress at ER levels causes the induction of UPR pathway 22926 1998 468 7494 PMC11502918__F4 Diverse lncRNA-medicated signaling pathways targeting different hallmarks of cancer (lncRNAs written in black and red color represent oncogenes and tumor suppressors, respectively) 652995 100124700 100885775 283120 643911 6659 728655 503639 85028 8888 51214 55384 55000 80154 60674 378938 101927152 2475 PMC11502918__F5 An intricate relationship between ER stress and lncRNAs: bidirectional relationship between ER stress and lncRNAs in the context of the UPR pathway 55384 619501 7494 468 6023 647979 80154 22926 PMC11502918__F6 LncRNAs in ER stress-driven HCC progression 60674 55384 468 619501 80154 572 6023 6648 PMC11504183__F1 BMP concentration on fate of ectodermal cells to induce epidermal, placodal, neural crest, and neural derivatives 3280 6495 6469 5080 PMC11504183__F2 BMP signalling pathway and modulators during development of pre-placodal ectoderm 57045 650 652 655 4086 4090 4089 PMC11504336__F2 Complex pathological processes during PCO formation under oxidative stress 4041 4040 324 4087 4088 4089 1499 PMC11504336__F3 Role and mechanism of Grx1 and Grx2 in protection against PCO formation 8011 4041 4040 3611 324 1499 999 1000 6935 PMC11504891__F2 CSF-1R axis mediates the crosstalk between tumor microenvironment cells 3579 2191 383 146433 3569 PMC11505051__F3 Onset and exacerbation pathogenesis of chronic inflammatory respiratory disease by PM exposure and associated ROS signaling pathway 260431 4353 3458 3569 6347 3383 4513 727897 3565 3567 3596 7082 999 PMC11505051__F5 Pathogenesis of inflammatory skin disease and aging by PM exposure and associated ROS signaling pathway 196 581 572 5366 3552 4014 3569 4513 7124 3383 PMC11505109__F2 DNA damage response (DDR) pathway activates the ATM-CHK2-P53 signaling pathway and inhibits CDK2 expression, thereby affecting the G1/S transition 472 545 1017 7465 993 995 983 PMC11505293__F2 Updated PCOS network: network depicting the associations (connecting lines) of PCOS-relevant genes/gene products (nodes) 3814 84634 1081 2798 2488 3087 9210 269 268 2693 79068 3949 9340 551 1803 27035 2805 5093 2641 2626 6934 3688 89122 885 3659 1588 5094 6462 1634 183 1589 1586 1636 2875 6822 3630 7099 2100 8660 7037 4891 27324 23327 59272 7124 1740 91 3739 7704 2066 2033 57817 2512 596 60 3553 3552 10552 9611 5728 2539 4790 3576 7799 8633 1639 5781 3309 5599 7157 4780 23028 65018 6648 9869 4582 23410 2176 10018 823 6203 11103 10155 51317 80312 54790 7592 7515 4589 23657 24140 10168 10111 252969 7579 79623 63892 23660 22919 2879 2938 705 831 10024 2939 2182 11343 1268 11132 121549 84467 PMC11505293__F4 Polycystic Ovary Syndrome and Ferroptosis: Following Ariadne’s Thread 2939 121549 2938 4780 2539 2879 2182 6648 23410 5094 5093 4891 7037 27035 1803 3569 57817 3630 4790 3091 7157 51317 54790 80312 65018 5728 472 4582 4589 79623 4087 91 23327 2512 PMC11505501__F1 Mechanisms underlying signaling pathway crosstalk in OA 7124 920 7189 1499 860 799 7852 126014 3690 1513 54 4090 4086 4087 4088 PMC11505556__F11 Therapeutic effect of baicalein against insulin resistance (IR) 3643 2475 3667 PMC11506062__F1 Comparison of the major metabolic pathways in (A) normal and (B) cancer cells 8140 2475 6510 PMC11506062__F2 Major metabolic pathways at work within cancer cells 7086 2475 2539 57103 2597 2023 55902 27165 8140 6009 31 2194 6319 3156 PMC11506204__F1 Signal pathways of calycosin in breast cancer 100124700 10642 79084 10538 50943 5874 51655 581 PMC11506204__F2 Signal pathways of formononetin in breast cancer 3479 2475 5728 2358 1019 PMC11506204__F3 Signal pathways of astragaloside IV in breast cancer 10451 5879 693198 2308 PMC11506310__F1 TRAIL-induced pro-apoptotic signaling pathway 8772 637 581 317 331 PMC11506310__F2 Non-canonical TRAIL signaling pathway 5879 6774 6714 8737 8772 7186 11035 197259 1386 PMC11506335__F3 Comparison of ATR activation and signaling pathway in interphase and in mitosis 545 84126 54465 11073 983 7465 PMC11506434__F6 NPS-1034-targeted pathways in RCC 558 7132 1647 PMC11506536__F2 Illustrates the multifaceted mechanisms of action of niclosamide in cancer treatment 324 2932 2475 6774 253260 6009 23440 PMC11506648__F6 AREG’s role in ESCC-MSC interactions 1956 374 9242 2191 PMC11506738__F3 Key pathways of COVID-19 vaccine-induced adverse immune reactions 7054 324 117194 PMC11506738__F4 Various mechanisms of adverse immune activation by COVID-19 vaccines 5196 54106 51284 51311 3565 3458 115004 3567 3596 3665 3661 7124 PMC11506742__F2 IRAK1 in the metastatic cascade 3654 2919 1000 983 8318 8317 4171 7124 3586 6364 6352 7412 3383 8205 PMC11507121__F6 Transcription and expression analysis of genes related to wax synthesis pathway in leaves of ‘Ningqi I’ goji and ‘Huangguo’ goji 95 55711 9350 PMC11507252__F5 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review 114548 4615 7099 PMC11507252__F6 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review 23411 581 4899 PMC11507252__F7 Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxicity: A Review 2475 9474 10533 PMC11508835__F1 mTOR signaling pathway 2887 3667 5163 5728 1855 4041 4040 729438 652968 83667 6502 220441 3551 55437 64798 7248 7249 6009 PMC11508835__F2 Insulin/PI3K/AKT signaling interactions with mTOR 2932 7248 7249 6009 51256 5594 1147 5604 5894 5170 3265 2885 6654 5728 3479 3667 2887 PMC11508835__F3 AMPK signaling pathway 55437 7248 7249 6009 51256 PMC11508835__F4 Amino acid pathway interaction with mTORC1 83667 652968 6502 220441 729438 153129 10542 8140 6520 57600 201163 PMC11509156__F3 Metabolite Profiling of Macroalgae: Biosynthesis and Beneficial Biological Properties of Active Compounds 4553 2638 5498 PMC11509893__F2 Possible mechanisms involved in the therapeutic effect of acacetin on liver disease 6774 619501 7099 4088 2475 PMC11510019__F3 Illustration of MEHHs’ phenolic acids regulating lipid metabolism pathways 1081 355 3156 51 3158 338 23411 PMC11510019__F4 Depiction of how MEHHs phenolic acids regulate the insulin pathway 1081 8660 3667 PMC11510019__F5 Illustration of MEHHs’ phenolic acids mitigating the inflammatory response by modulating various pathways 1081 4615 10628 114548 9817 7124 3383 7412 PMC11510019__F6 Illustration of MEHH phenolic acids mitigating oxidative stress by modulating various pathways 95 468 1081 2876 847 1728 PMC11510049__F9 Comparative analysis of transcript and protein abundance in the HSP60-HSP70-TLR2/4 signaling pathway in children with severe malarial anemia 929 7097 4118 51135 4615 7099 7189 10454 23118 257397 847 9308 958 969 942 941 3383 PMC11510507__F5 Signaling pathway diagram of phagosome (the images are sourced from the DAVID database 2024 9341 53407 811 7097 7099 929 10333 8685 948 83547 7982 203068 4353 PMC11512255__F6 Schematic model illustrates the mechanism by which HSV-2 UL24 blocks the IRF-3 signaling pathway 3661 57506 29110 PMC11512478__F8 Mechanism of CHRDL1-MED29-mediated interruption of EMT evolution in OSCC 91851 85451 999 55588 1000 PMC11512513__F3 Signaling pathway with UPS-related muscle wasting in cardiac cachexia 3479 7124 3569 3480 3667 2475 84676 PMC11513202__F2 Relationships between DNA methylation and hepatocellular carcinoma (HCC) proliferation, apoptosis and angiogenesis 595 1019 4193 841 PMC11513202__F4 Relationships between DNA methylation and sorafenib resistance in HCC 1788 22880 4771 283120 79885 664 665 1786 1544 6774 3066 54790 619501 PMC11513202__F3 Relationships between DNA methylation and adhesion, invasion and metastasis of HCC 999 1013 7078 5340 4312 4314 2016 1956 PMC11513202__F7 Pivotal role of DNA methyltransferase in DNA methylation and HCC progression 2475 999 3082 93649 56666 56956 2146 1786 11186 2626 8999 9112 1788 1789 PMC11513379__F2 Nanomedicine in HNSCC therapy-a challenge to conventional therapy 7039 1950 1956 6714 2885 3480 5728 5979 6774 5608 5058 1786 2475 4513 1869 5111 PMC11513491__F3 Schematic illustration proposed for the probable role of PI3K axis in AML cells 5728 84973 2475 PMC11514642__F9 Abnormal expression of MECOM in uterine corpus endometrial carcinoma and its mechanistic involvement in regulating the Hippo signaling pathway and affecting cell cycle and apoptosis 2122 50943 4087 4088 595 PMC11514755__F8 NF-kappaB signalling pathway 3929 114609 3654 51135 929 4615 7189 7099 7185 7186 331 3569 4513 7412 941 942 PMC11515775__F2 Caffeine metabolism pathway and metabolites 196 5447 1544 10 1548 9429 PMC11515775__F4 Genetic variants and their effects on caffeine dependence 6532 51085 1312 1813 627 283450 1544 217 57107 196 1548 9429 5447 PMC11516169__F9 CsEVs in promoting malignant proliferation and metastasis of CCA cells 1017 1019 1021 595 999 896 PMC11518755__F2 NIS expression 7253 4087 4088 4089 7849 7270 PMC11519383__F7 Schematic summary of the study 861 7057 7040 PMC11519594__F6 Mechanism diagram of m6A-autophagy-mediated tumor treatment resistance 79068 56339 9474 54915 8408 2309 10643 51372 2475 79066 8878 84837 10054 394 22926 65018 167227 4924 8975 51441 PMC11519594__F7 M6A autophagy axis involved in tumor signaling pathway network 4077 441951 57721 79068 58476 10643 378938 54915 8678 3181 23192 10533 PMC11519599__F2 Signal transduction pathways of necroptosis under HS 8717 8737 7186 197259 8772 11035 81030 7098 3297 PMC11519599__F3 Signal transduction pathways in ferroptosis under HS 6520 7099 23657 2879 2182 7004 7003 PMC11519791__F10 An illustration of the proposed role of cholinergic and calcium signaling pathways in ISIAF and WK treatment in neuronal and non-neuronal (cardiac) systems 43 1131 1103 PMC11519876__F1 Reelin signaling pathway in Alzheimer’s disease (AD) 1600 6714 7436 PMC11520424__F2 Main STAT3 signal transduction pathways in breast cancer 1950 9021 6774 3266 2475 1956 6714 7018 5292 1271 9180 3977 3575 50615 2690 5789 5788 11122 1844 10155 10401 PMC11520425__F2 Wnt signalling regulation of osteoblasts and osteoclasts 4041 4040 1499 4163 4920 387 6010 6714 29941 PMC11520539__F3 Diagram illustrates the immune exchange pathway mediated by ADAR1, a dsRNA A-to-I editing transformation modulating enzyme 3563 3717 6776 389421 103 PMC11521822__F6 The angiogenic signaling pathway in lean vs 51094 79602 7291 PMC11521927__F3 Various signaling pathways activated by TGFB1 stimulation and their partial cross-talk are outlined 5728 7189 57154 64750 100616437 4087 4088 80176 2885 4089 4091 4092 3611 9618 554212 PMC11522688__F9 Schematic illustrations of AMSC-EV and HUMSC-EV repairments on photoaging in vitro and in vivo via regulation of the TIMP1/Notch pathway (Created with BioRender 7076 9242 4851 102 3280 4280 23411 PMC11522757__F1 Regulated cell death (RCD) pathways implicated in pathological cardiac hypertrophy 581 114548 7124 11035 197259 2879 8031 4025 79792 2475 9706 PMC11522771__F2 Signaling pathways involved in cardiac fibrosis 650 4091 4087 4088 64093 57154 PMC11523104__F1 2–3% of glucose entering the cell is diverted from glycolysis into the hexosamine biosynthetic pathway (HBP) 55577 8473 10724 PMC11523277__F1 Effect of ubiquitination imbalance on osteosarcoma cells and its clinical application 8239 7874 7398 10293 6737 25820 285671 4193 80128 PMC11523277__F2 Ubiquitin-mediated regulation of key signaling pathways in tumor cells 9616 23032 10869 9101 23608 10600 9866 9099 8405 8452 7375 8450 9100 7726 8453 84133 7874 58495 83737 9960 54894 55294 4193 29089 6737 4591 8079 PMC11523277__F3 Dysregulated ubiquitination pathway drives osteosarcoma malignancy 5159 6737 286077 25820 9817 80128 1499 387 1 26292 6282 8239 8078 285671 10293 9759 79586 8535 1022 5427 4193 23326 5111 10346 3486 6502 1316 860 7874 114548 284930 23411 7398 4209 83746 960 54890 9810 2475 PMC11523277__F4 Potential of ubiquitination modulation in osteosarcoma treatment 6657 57403 7874 56852 10155 6047 80128 55294 7398 65992 84133 1869 PMC11523861__F1 Dietary Sources of Tryptophan and Main Pathways of Tryptophan Degradation (a) Tryptophan, an essential amino acid, is commonly acquired from dietary sources such as turkey, eggs, cheese, tofu, seeds, and fish 125061 8564 8942 23498 23475 15 438 PMC11523861__F2 Tryptophan Sample Collection, Detection Methods, and Biological Functions Samples for tryptophan detection are typically obtained from blood specimens, cancer tissues, and cancer cell lines 4397 958 920 613 PMC11523861__F3 Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer 125061 8942 8564 196 8140 6510 PMC11523861__F5 Molecular Mechanisms of Tryptophan Metabolism in Digestive System Cancers (a) Tryptophan metabolism plays dual roles in digestive system cancers, promoting or suppressing tumor growth 4609 8140 991 196 3458 920 4353 PMC11524014__F3 Carbon dots in anticancer immunotherapy 4478 51185 3569 942 941 3553 PMC11524448__F8 T3SS triggered LTB4 synthesis differs between neutrophils and macrophages 4067 3055 2268 6850 114548 8935 6786 834 PMC11524886__F3 Potential mechanisms by which exercise-mediated release of irisin exerts antidepressant effects 252995 7350 627 7099 4615 7351 PMC11525629__F1 Signaling pathways activated by mito-DAMPs 57506 3665 3661 54106 115004 114548 4615 9447 PMC11525629__F3 MAOs in the suppression of antitumor immunity 5727 6469 6778 3565 3596 8205 PMC11525935__F7 MiR-126 can inhibit the PI3K signaling pathway, promote M1 macrophage polarization, and suppress the activation of FAK and Rac-1, thus accelerating the progression of UUO 3667 9332 4318 PMC11526712__F1 Study workflow: Four differential microbial strains were found in the fecal microbiota of Laiwu pigs and Lulai black pigs 94005 6009 7248 7249 6772 9332 PMC11526712__F8 Pathways through which E 5728 7248 7249 6009 PMC11526956__F1 Distribution of dNdS values for genes encoding proteins involved in upstream and downstream NFLs across various signaling networks 27122 8651 26524 9113 8313 1499 PMC11528219__F2 Stomatal development by environmental signaling in Arabidopsis 759 762 2077 23379 PMC11528463__F7 BC-derived CAV1 promoting BC lung metastasis 857 6440 6714 6347 7099 114548 4318 PMC11528492__F5 Bioinformatic reconstruction of the L 727 4553 7909 1431 7216 3242 7360 5053 PMC11529026__F2 Smad-dependent and Smad-independent TGFB signaling in EndoMT 4089 4087 4088 7046 7048 6935 999 1000 PMC11529186__F6 Peripheral nerve injury exacerbated progression of muscle HO, caused by the release of NRG3, which induced osteogenic differentiation of FAPs via the ErbB4/PI3K/Akt signaling pathway 10718 2066 860 PMC11529329__F2 RPs interacting with p53 and MDM2 4193 619501 6135 9349 6125 6154 6158 6181 7099 PMC11529329__F3 RPs and proliferation of HCC 619501 6210 6233 6164 1020 1019 595 7391 6132 10399 873 PMC11529329__F4 RPs and metastasis of HCC 1499 6210 2261 6194 8817 4318 9349 7398 6217 6176 PMC11529338__F3 Osteoclast-mediated bone resorption reactivates dormant tumor cells 29110 7852 4920 3977 6387 655 7474 3976 2475 27122 649 7042 1000 2621 PMC11529338__F5 Bone microenvironment of prostate cancer with bone metastasis 27319 10419 1437 5935 5745 7048 56339 1499 920 PMC11529444__F2 O-GlcNAcylation cycling and UDP-GlcNAc synthesis 6675 285203 8473 10724 PMC11530815__F2 Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment 637 572 2475 2885 PMC11530815__F3 Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment 8772 637 581 PMC11531110__F8 Metabolic pathway analysis and metabolite-protein interaction networks in broiler chickens challenged with CP and its different toxin combinations 55364 4842 2618 216 PMC11531110__F9 Integrated metabolic pathway network analysis in NE-affected jejunal tissues 5832 4842 4843 384 4942 5091 1431 2628 8974 PMC11531143__F1 PIM kinase family gene structures 5292 11040 8835 3091 3205 51199 415116 PMC11531143__F2 PIM1 enhances aggressive oncogenic characteristics in breast cancer through multiple mechanisms 3570 5292 864 4851 4854 572 1026 1030 367 10397 3190 10155 829 4772 PMC11531143__F3 PIM1 signaling in Hepatocellular carcinoma 5292 3570 1956 6935 999 572 PMC11531143__F4 PIM1-mediated signaling pathways in lung cancer 2549 5292 2885 2475 581 999 257397 3939 3099 PMC11531143__F5 PIM1 activates AKT signaling in ovarian cancer 2668 5292 2475 5230 572 1950 1956 50853 595 1021 PMC11531455__F7 A5-nAChR and SOX2 signaling cascade is involved in lung cancer progression and immune escape 8205 6774 6657 PMC11532153__F3 Functions of p120-catenin in physiology and diseases 387 7099 114609 4615 3661 PMC11532857__F4 MicroRNAs in EMT process 3659 2475 6774 6732 PMC11532857__F5 MiRNAs in metastasis of HCC 619501 6732 102 6774 999 1499 PMC11532857__F6 MiRNAs regulating glycolysis in HCC 619501 5728 2475 3099 3939 PMC11532857__F7 MiRNAs regulating angiogenesis in HCC 5156 4313 54567 3082 PMC11534180__F11 Alzheimer's disease pathway modified from the KEGG database [29] 351 57142 10313 3416 65057 28 90550 6622 4023 8772 637 100653365 842 836 100506742 22926 7186 1998 468 7124 1020 324 203068 4513 2475 60673 8408 9776 29982 3630 3643 PMC11534180__F13 PPI subnetwork of DEGs from HC and EC tissue 6616 808 6857 2597 60 203068 23521 828 6124 6203 6132 PMC11534180__F5 Synaptic vesicle cycle pathway modified from the KEGG database [29] 100170220 5864 6616 4905 PMC11534180__F6 GABAergic synapse pathway modified from the KEGG database [29] 2744 2717 4905 PMC11534336__F1 Schematic models of the core of MAPK/ERK pathway and human eIF3 complex 2002 595 1999 2885 5058 5063 5062 7248 7249 6009 27250 29904 PMC11534612__F1 Pathophysiologic roles of IL-17 signaling in cardiac fibrosis 84818 55540 132014 7186 7188 7189 1045 3569 2919 3576 3627 6374 PMC11534688__F11 Blestriarene C exerts an inhibitory effect on triple-negative breast cancer through multiple signaling pathways 2885 572 581 PMC11534861__F2 Histone lactylation in cancer 5187 7157 2861 3939 28969 3421 PMC11534861__F4 Relevant mechanisms of lactylation in the development of cancer by modulating TME 3091 56339 7422 50943 PMC11535070__F4 Proposed crosstalk model between TET1, WNT, mir200b, and miR494 in CRC progression 1499 9839 6935 648 324 PMC11535288__F7 Overall metabolic pathways altered in systemic (plasma) and lung tissue of OVA-induced asthma mice after BS012 administration 4280 5091 7038 4015 PMC11535355__F7 Proposed model 7189 3654 7124 3569 PMC11536562__F2 Alpha-KG homeostasis and m6A regulation 3417 79068 5214 1050 4609 3945 PMC11536562__F3 m6A modifications in fetal hematopoiesis and HSC maintenance 4280 51441 56339 91746 4851 64321 861 2624 6041 4170 596 572 581 6772 4609 4929 648 8321 5595 208 PMC11536562__F4 Promotion of ILC3 cell proliferation in m6A-dependent manner 54890 3164 4853 PMC11537654__F1 Homoharringtonine (HHT) directly binds the nuclear factor-kappa B (NF-KB) repression factor (NKRF) through the second double-strand RNA-binding motif (DSRM2), a nuclear localization signal for NKRF 4609 11184 5728 407975 4211 2322 3205 6667 7248 717 7249 2475 80312 PMC11537654__F2 Homoharringtonine (HHT) causes phosphorylated eukaryotic initiation factor 4E (p-eIF4E) to SUMOize more fully 5728 2475 1977 1017 95 102 6737 6612 26279 54947 PMC11537654__F3 Combination of homoharringtonine (HHT) and quizartinib inhibits the FLT3-AKT signaling pathway and its downstream targets (purple line) 581 2322 2475 PMC11537654__F4 Homoharringtonine (HHT) enhances the proapoptotic effects of venetoclax by inhibiting the MAPK/ERK and PI3K/AKT pathways and activating the p53 pathway (orange line) 5728 2932 472 545 4193 PMC11537862__F2 Brucella triggers inflammatory responses 10628 7186 64127 637 9447 114548 4615 PMC11537862__F3 Possible pathways of apoptosis inhibition by Brucella 1649 6390 4726 1152 4831 4734 PMC11538000__F1 Pyroptosis regulation by Salmonella effectors 114548 79792 5163 6010 197259 1687 PMC11538000__F3 Salmonella plasmid virulence factors and pyroptosis 114548 58484 79792 PMC11538887__F8 Mechanism of exosome treatment of androgenetic alopecia 367 4345 5111 PMC11539687__F2 This figure illustrates the neuroprotective mechanisms of GLP-1 receptor agonists (GLP-1RAs) in neurons and microglia, highlighting the key molecular pathways involved in neurodegeneration and inflammation 2475 7019 581 114548 PMC11540160__F1g SOX4 protein in the nucleus of CD31+ HemECs binds to the downstream target gene ESM1, further activating the PI3K/AKT signaling pathway 7422 6714 6659 11082 2475 PMC11540618__F7 Lipid metabolic profiling and diagnostic model development for hyperlipidemic acute pancreatitis 352963 5091 7454 PMC11541314__F6 Codeine and morphine Metabolism pathway as the most significant curated signaling pathway with a p-value of 3 1576 7363 1565 1558 7364 54658 54659 54600 1244 8714 5243 10599 PMC11541728__F2 Signalling pathway of ephrin receptors (EphR) is depicted 6714 5879 6010 998 PMC11542157__F6 CMA dysfunction contributes to multiple diseases 114548 4170 1956 5076 1950 PMC11542427__F3 Shows that, owing to aging, there is an increased release of proinflammatory adipokines that stimulate the activation of TNF, TGFBR, and insulin receptors 4088 8408 324 2308 1499 7350 688 10682 PMC11542495__F1 Schematic diagram of Nrf2 and Keap1 domain structure: Nrf2, is a transcription factor characterized by multiple functional domains, including Neh2, Neh4, Neh5, Neh6, Neh7, Neh1, and Neh3 9817 6256 8452 PMC11542495__F2 Cytoprotective Mechanisms of HO-1: Heme oxygenase 1 is an enzyme responsible for the breakdown of heme into Fe²⁺, CO, and bilirubin, which is subsequently converted to bilirubin by BVR 9817 571 26263 PMC11542495__F3 Regulatory mechanisms for Nrf2/HO-1 signaling pathway: Under normal conditions, Keap1 mediates the ubiquitination and proteasomal degradation of Nrf2 by binding to Nrf2 and interacting with the CUL3 ubiquitin ligase complex 8452 9817 2879 4094 3725 1728 PMC11543427__F3 The formation of VSMC-derived foam cells induced by ox-LDL 7474 4035 4067 948 51548 7942 54209 19 PMC11544004__F5 Dynamics of activation signaling in NK cells in contact with cancer and stressed cells 7917 5817 962 3383 100507436 4277 79465 80329 80328 27040 6850 6714 2885 7409 7535 10451 7410 5879 3458 1398 867 2308 PMC11544004__F9 Impact of the environment on NK cells: Phytoncide model 196 405 3458 1543 1545 3620 57491 7166 51676 PMC11544107__F4 Distribution of key targets in the two main pathways 6401 799 133 137735 551 5724 1392 5443 1511 4295 2695 2696 10874 8620 5367 594857 387129 2492 2691 183 4852 3973 100506013 8862 4018 5741 256933 4922 680 2922 6697 6343 6344 3827 706 718 3060 1442 2690 5020 6651 7067 1325 885 1909 3952 51083 2587 80763 6863 1537 140805 367 1610 5624 PMC11544107__F5 Aripiprazole-target-disease-pathway network and molecular docking results of aripiprazole with core targets 5979 10021 50808 54583 2534 140805 3274 43 6752 4067 3757 9429 4985 3354 2100 4988 348980 8484 213 1436 4986 8879 2912 695 8767 2260 3269 7026 59340 6580 51135 23030 1128 6865 1131 1129 4363 6531 3358 3351 1815 147 1814 5243 3363 1813 154 1812 1576 4129 7124 148 1816 153 1565 151 3356 152 3350 3352 3362 PMC11544397__F6 ERS induces renal fibrosis in high-fat diet mice via the TGFB/SMAD pathway 4087 4088 4092 PMC11544528__F5 Mechanisms by which NR4A1 regulates osteoporosis and adipogenesis via the Notch signaling pathway 3164 3280 860 PMC11544529__F2 DUBs in the PI3K/AKT, NFKB and MYC pathways in urologic cancers 1956 3480 7124 5728 7874 1540 5163 10713 51377 10600 8975 124739 2475 23326 PMC11544529__F3 DUBs in the RAS/RAF/MEK/ERK, p53 and TGFB pathways in urologic cancers 2885 7874 4193 8239 10869 10713 57646 4087 4088 4089 367 83844 PMC11544529__F4 DUBs in the Wnt/Beta-catenin and Hippo pathways in urologic cancers 7347 1499 4485 324 60485 29761 9736 26524 9113 1540 55793 PMC11544849__F4 Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research 999 1499 1950 PMC11545013__F10 Elevated RBP4 in Subclinical Ketosis Cows Inhibits Follicular Granulosa Cell Proliferation and Steroid Hormone Synthesis 5950 64220 9134 983 8900 595 581 6770 1586 1594 PMC11545099__F1 B cell receptor signaling pathway 613 973 974 930 4067 6850 695 5336 2475 PMC11545229__F8 ENAH-mediated OSCC progression 1950 1956 6714 2932 324 55740 1499 7018 3693 PMC11545288__F6 PPI network analysis of core targets screened from potential targets (A) and network diagram of the active component–key target pathway (B) of sugarcane vinegar polyphenols to mitigate oxidative stress 1081 3320 6774 367 4318 5970 2932 5743 4780 1017 PMC11545288__F7 Mechanistic Insights into the Antioxidant Potential of Sugarcane Vinegar Polyphenols: A Combined Approach of DPPH-UPLC-MS, Network Pharmacology and Molecular Docking 920 7187 6347 6364 7124 7054 100187761 6668 3934 6278 6280 29761 10129 PMC11545656__F1 Scheme of CD95 pathway 8772 581 637 317 PMC11545656__F2 Scheme of CD95-mediated apoptotic and non-apoptotic signaling 7186 8772 8737 PMC11545787__F1 Effect of Probiotics on Gastrointestinal Health Through the Aryl Hydrocarbon Receptor Pathway: A Systematic Review 196 405 57491 1544 1545 PMC11545879__F2 Various genes expressed by Tregs and their surface molecules 941 942 201633 6346 1237 6361 6367 1233 3627 4283 2833 3902 940 50943 2475 PMC11545879__F4 Mechanisms of Tregs in immune checkpoint blockade therapy 940 941 942 324 10666 201633 2885 9815 4087 4088 5062 10538 7535 7189 50943 PMC11545938__F1 Sphingosine-1-Phosphate Signaling Pathway in Pancreatic Diseases 1903 8698 1901 9294 56848 PMC11545986__F3 Circadian dysregulation of lipid metabolism and adverse pregnancy outcomes 9575 406 8864 8863 1408 4018 1374 1375 37 PMC11546116__F2 Regulatory mechanisms involved in myocardial regeneration 9242 3084 2066 2064 1499 1874 1870 1019 1869 1017 57057 983 PMC11546116__F3 Vascular regeneration after MI 9242 54567 4851 PMC11546156__F1 Brief molecular mechanisms of the autophagy signaling pathway 22863 7405 9776 9706 8408 9140 9474 83734 10533 64422 PMC11546748__F2 Molecular and hormonal pathways contributing to insulin resistance in gestational diabetes 2475 5163 3569 3606 6347 PMC11546859__F11 Analysis of the glycolysis/gluconeogenesis metabolic pathway 130589 2821 1737 2597 1738 5132 5162 PMC11546914__F3 AI-Assisted Identification of Primary and Secondary Metabolomic Markers for Postoperative Delirium 3458 3952 3586 6347 3569 3002 468 79068 968 16 7453 10352 958 3735 3684 6850 PMC11547089__F10 Expression of genes involved in AsA biosynthesis in L 130589 2592 3628 55586 PMC11547105__F5 Comparative Metabolomics to Unravel the Biochemical Mechanism Associated with Rancidity in Pearl Millet (Pennisetum glaucum L.) 355 5091 4099 PMC11547603__F1 Activation of the components of the TGFB/Smad canonical signaling pathway initiates the fibrosis process by inducing transcription of the downstream fibrotic genes 7048 7046 4088 PMC11547603__F2 Activation of TGFB stimulates NFKB and MAPK signaling pathways with the subsequent activation of the Wnt/Beta-catenin pathway 7048 7046 7189 9618 PMC11547603__F4 Interaction between non-canonical Wnt/Beta-catenin and TGFB/Smad signaling pathways to stimulate the fibrogenesis process and transcription of the downstream fibrotic genes 4087 8325 81029 1499 PMC11547603__F5 An overview of role of TGFB in the pathogenesis of intestinal fibrosis 1278 1277 7076 4312 4318 5728 406991 2475 PMC11547832__F8 DOE is involved in the Akt signaling pathway to regulate protein synthesis and lipogenesis 3667 7350 4620 PMC11548906__F2 Regulation of adipogenesis in lipedema 257194 84935 2066 4086 4090 4089 4015 2247 5468 3976 6422 2200 5593 80031 84034 3479 54 4060 22933 23411 2624 2625 118 1051 1435 1436 80114 127018 1050 4360 968 PMC11549395__F5 Regulatory network of the 32 DEMs and the 66 DEM-regulated DEGs was drawn by Cytoscape 3 1278 6790 367 983 991 8318 4173 9700 57082 7272 7473 9319 4998 3236 2318 7291 7472 2817 57817 8322 PMC11549404__F9 Molecular mechanisms underlying FNDC4-mediated protection against cardiac I/R injury 2246 64838 3091 PMC11549785__F1 LncRNAs modulate MR of solid tumor cells by targeting glucose metabolism 283131 100506190 2023 5223 5230 2475 9474 9140 202299 339529 10644 3939 PMC11549785__F2 LncRNAs modulate MR of solid tumor cells by influencing lipid metabolism 145820 3183 5465 1374 948 2167 283131 2171 123706532 2180 4869 PMC11549785__F4 LncRNAs orchestrate MR in solid tumor cells by influencing interactions between tumor and non-tumor cells in TME 8205 283587 9547 3939 100188953 5208 PMC11550943__F3 Metabolic pathways for a metabolism of glucose via the classical hexosamine pathway has a rate-limiting step at phosphofructose kinase (PFK1) that is inhibited by ATP, low pH and citrate 6652 3795 2597 PMC11550995__F3 NFKB signaling pathway 1956 6774 7124 958 4055 4615 7186 8915 10892 5971 PMC11550995__F5 Noncoding RNAs in rheumatoid arthritis: modulators of the NFKB signaling pathway and therapeutic implications 958 4055 4615 1956 7186 6774 8915 10892 207 5971 PMC11551531__F4 JAK/STAT signaling pathway in macrophage polarization 8651 6774 3718 6778 9021 PMC11551531__F5 Notch signaling pathway in macrophage polarization 3280 54626 388585 4615 PMC11551531__F6 TGFB/SMAD signaling pathway in macrophage polarization 4091 7939 4087 4088 PMC11551650__F3 MET oncogenic activation 3082 867 7175 3123 3799 5803 PMC11551650__F4 Hepatocyte growth factor/c-Met axis activates the Hedgehog pathway through downstream signaling 3082 2885 2549 6774 374654 6608 2735 2737 2736 51684 2475 64399 595 PMC11551650__F6 C-MET pathway relays downstream signals to activate multiple oncogenic events to promote cell proliferation, migration, protein synthesis, and antiapoptosis 3082 572 2475 2885 2549 6774 4193 PMC11551672__F1 Under the tumor microenvironment, abnormally activated wingless/integrated signaling pathway in cancer cells can be interpreted as an M2-tumor-associated macrophage polarization mediator 2932 324 1499 8205 PMC11551840__F6 Proposed modes of mechanism of action of AZD5582 in OSCC 7124 55072 8717 7186 8772 841 197259 PMC11552210__F2 Molecular pathways involved in the increase of fibrosis in the ovary and uterus by exposure to micro/nano plastics 3146 7099 367 4087 4088 4318 4313 PMC11552248__F1 Adhesin RadD: the secret weapon of Fusobacterium nucleatum 201633 999 4318 5111 PMC11552340__F1 WNT signaling pathways affected by WNT6 in cancer 7475 1499 4920 324 6774 387 1386 5754 6259 3725 PMC11552340__F3 Compounds that target components of WNT pathway 8658 324 1499 PMC11552425__F2 Whole-exome sequencing in cerebrovascular diseases 10085 114795 9659 162514 122970 100187761 4854 8985 102 4799 50863 7173 94 727897 4036 113189 PMC11554266__F3 This illustration details the PI3K/AKT/mTORC1/HIF1A pathway, focusing on its regulatory role in glucose uptake through GLUT1 and GLUT4 transporters 1956 5163 3091 PMC11554530__F2 Functional plasticity of Tregs and Th17 cells 3620 201633 50943 3586 6774 5728 PMC11554578__F2 Exemplary Ca2+ signaling microdomains 6262 6263 84876 54822 6261 6786 7416 PMC11554632__F1 Outline of force-sensing proteins in cardiovascular system 9780 2475 1019 595 PMC11555136__F5 Signaling pathway involved in the development of persistent bladder hyperalgesia 4282 3146 7099 4615 PMC11555182__F1 KEAP1-NFE2L2 signaling pathway 8452 9978 9817 4780 PMC11555182__F2 NFE2L2-dependent genes in ferroptosis 4780 8924 7037 30061 3162 23657 6520 8031 2495 2512 2235 10058 84883 2937 8544 4495 2539 1728 4257 2182 2879 2936 PMC11555290__F1 (By Figdraw, ID: RASTR41933) Mechanism of fibrosis promotion by malignant tumors: Tumor cells secrete pro-fibrotic factor TGFB and activate CAFs through the TGFB/Smad signaling pathway 4089 4087 4088 PMC11555290__F2 Decoding tumor-fibrosis interplay: mechanisms, impact on progression, and innovative therapeutic strategies 90865 374 1956 PMC11555832__F3 Resistance to PD-1 blockade in CRC 4099 567 5728 PMC11555832__F4 Facilitating tumor cells recognition by innate immune cells 7099 51284 51311 7098 54106 4615 7189 7186 7187 100187907 115004 23586 3665 3661 PMC11556706__F1 Phase regulation of Ca2+-cAMP oscillation and corresponding mathematical modeling 3550 4827 11216 PMC11557232__F6 Model for the functions and acquisition pathways of acetyl-CoA in multiple organelles of Toxoplasma 4118 11113 324 PMC11557563__F2 Glycolysis and its ancillary pathways in WB muscle 26227 3939 3945 PMC11557815__F3 Impact of P 3596 3569 6352 58191 6722 93649 860 5175 PMC11558907__F2 Function and main molecular mechanism of various adipokines on myocardial ischemia/reperfusion (I/R) injury 3146 7099 10487 284207 115004 8408 3656 78986 6774 3717 23411 948 PMC11559183__F1 Regular neuregulin 4 (Nrg4)-erb-b2 receptor tyrosine kinase 4 (ErbB4) signaling pathway 2066 145957 1950 PMC11560026__F11 Mechanism by which SH3KBP1 impairs PRRSV replication, created in BioRender 30011 7706 57506 29110 3661 PMC11560437__F4 Aquaporins in sepsis- an update 358 366 360 6667 PMC11560440__F4 Pathogenesis of SjD 51311 920 942 PMC11560455__F1 Ferroptosis signaling pathway 7018 7037 55240 30061 2182 2643 10162 1723 4015 2879 PMC11561128__F8 GLS2-mediated glutaminolysis accelerated AS process by encouraging endothelial mitochondrial dysfunction and pyroptosis via SIRT3/FOXO3a axis 23410 79792 114548 27165 PMC11562642__F5 Schematic diagram illustrating the toxicity mechanism of MNNG in the gastric mucosa and the protection mechanism of FA against MNNG-induced gastric mucosal injury 114548 5728 2475 PMC11562816__F1 Low-frequency variants in genes involved in glutamic acid metabolism and Gamma-glutamyl cycle and risk of coronary artery disease in type 2 diabetes 2730 2752 2678 2937 2571 2744 2729 64174 79017 26873 2572 5832 2805 2806 PMC11562918__F3 HSV-1 mediates innate immune signalling and escape strategies 7097 4615 115004 54106 7098 3428 57506 51428 7189 7187 58484 867 29110 3661 114548 PMC11563827__F5 Peri-implantitis involving multiple signaling pathways 7471 89780 7474 7097 7099 4615 7189 PMC11563829__F2 Major downstream events of Trop-2 6714 999 10399 3480 102 PMC11563972__F3 Curcumin in the treatment of Parkinson’s disease (PD) 9817 7099 1499 PMC11565213__F2 PIK3CA gene mutation activation of PI3K/AKT/mTOR signaling pathway will resist the action of anti-EGFR monoclonal antibody on EGFR signaling pathway, resulting in resistance to EGFR monoclonal antibody in colorectal cancer patients 5290 2475 1956 673 PMC11566155__F10 Novel function for Alpha-synuclein as a regulator of NCK2 in olfactory bulb: implications for its role in olfaction 100187761 2043 8440 6010 PMC11566155__F7 Axon guidance pathway analysis 387 2534 998 4690 8440 7852 6387 6585 6092 9353 6091 64221 29984 27289 10371 2242 5810 8482 5727 6469 6608 3611 6259 5163 8863 655 151449 PMC11566304__F1 Metabolic pathway diagram of hypoxanthine 7067 5640 5814 5813 3258 PMC11566422__F2 ENO1 and its targeted therapy in tumors 2023 1499 6657 960 595 4316 PMC11566422__F3 ENO1 and its targeted therapy in tumors 80381 54918 140885 961 2023 53834 6714 2191 85478 1499 6657 960 4316 595 PMC11566475__F9 Metabolic pathway gene association network 203068 6309 1490 991 7465 PMC11566483__F2 NLRP3 inflammasome construction and activation 7124 114548 5763 79792 140609 PMC11566483__F4 Caspase-3/8/9- and granzyme-mediated pathways 7124 331 11035 8737 8772 3002 3001 824 823 581 637 79792 56169 1687 55876 PMC11566834__F8 Optogenetic stimulation of the “Zusanli” acupoint alleviates inflammatory pain through active Wnt/Beta-Catenin and MAPK signaling pathway in rats 2885 324 1499 PMC11568081__F2 Figure illustrates how kaempferol induces apoptosis in digestive system tumors 8549 983 355 572 3725 1594 581 638 637 7052 114548 PMC11568081__F3 Figure illustrates how kaempferol inhibits digestive system tumors cell proliferation 472 3845 995 3014 3178 5725 581 983 891 PMC11568081__F4 Figure shows how kaempferol suppresses metastasis and invasion while inducing autophagy in digestive system tumors 1956 6714 2475 983 9474 10533 9140 581 PMC11568081__F5 Figure illustrates the mechanism by which kaempferol enhances sensitivity to anti-digestive system tumor drugs 1956 6774 637 3178 581 5725 PMC11568095__F10 Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway 3479 2885 6654 4318 4313 PMC11568601__F9 Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway 22926 7494 142 PMC11570929__F4 mTOR signaling pathway and cellular senescence 6009 7249 55615 7248 64798 595 1019 PMC11570929__F5 Insulin-like signaling pathway and cellular senescence 3716 6774 8660 3667 2475 7248 7249 6009 PMC11572133__F7 LPAR3 regulates EPO induction by hypoxia 7428 4018 23566 PMC11572637__F1 Elafibranor on alcohol-associated liver disease in mice 5465 6647 847 7099 PMC11573773__F2 SLC34A2-Bmi1-ABCC5 signalling pathway hypothesis diagram 10568 10057 648 PMC11573773__F3 Regulatory pathways of ABCC5 in cancer 9817 2305 648 10057 PMC11574184__F6 KEGG pathway analysis 920 7124 100187761 9118 8717 1540 331 64127 6401 6955 PMC11574213__F3 New insights into crosstalk between Nrf2 pathway and ferroptosis in lung disease 6774 9817 23657 7015 7124 2879 1728 4094 PMC11575037__F14 Figure shows selected subnetwork of the differential network for Artery Coronary tissue in Atherosclerosis 4846 9370 4353 2171 5465 1071 5468 5891 4023 1803 PMC11575037__F16 Selected subnetwork of the differential network for Artery Tibial tissue in Atherosclerosis 1071 3952 4846 5891 4023 4982 2167 2171 3082 4282 PMC11575037__F3 Figure shows selected subnetworks of the differential network for Liver tissue in Diabetes 83605 100 268 255738 5443 1571 3082 383 6364 729230 940 51277 6352 6097 4353 366 4880 1803 57761 3164 31 3934 2678 1236 30009 23410 9437 9447 916 219623 2645 3458 19 942 79689 79924 11035 11274 185 8651 7226 2852 467 5590 59272 59341 10461 114548 6775 145957 1636 28 6095 10863 54209 1524 5468 4311 1594 23098 6351 53831 152831 5140 257000 4306 2150 375616 116986 3084 9450 6462 1235 7124 11072 5008 57124 925 9476 PMC11575037__F5 Figure shows Selected subnetwork of the differential network for Aorta tissue in Diabetes 940 116986 117159 57085 1386 59341 5167 128486 390 1810 3084 5465 10461 152559 268 11266 219623 412 59272 1636 5008 3991 6775 3667 7226 79068 7124 79671 64838 4023 11274 1524 8788 916 3931 10170 384 5443 54106 4353 30009 3934 472 1803 114548 375616 942 727 1950 2645 28 9450 729230 1879 1571 383 6351 197259 7098 5590 114609 355 4880 50507 100 1956 2678 30837 1236 3659 652 1794 4306 11213 3662 7097 4311 9476 285 257000 3082 23411 920 57761 11035 79924 146433 6095 4968 145957 9935 9759 3949 19 10863 2887 7185 PMC11575037__F7 Figure shows selected subnetwork of the differential network for Heart tissue in Diabetes 83605 6347 100 27434 847 133 1636 213 9476 472 31 3991 PMC11575122__F9 CARMN mechanism involving transcriptional and post-transcriptional regulation 728264 6667 1660 4904 7020 5603 9817 PMC11575262__F9 Seed and foliar application of nano-selenium improves sesame triacylglycerols and oil yield via photosynthetic pigment and enzymatic and chemical antioxidant enhancement revealed by spectrophotometric, UHPLC-analysis and chemometric modeling 95 5091 2875 847 10350 PMC11575309__F7 DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2+ breast cancer 920 54567 3516 1991 4353 9601 PMC11575457__F1 [KRAS signaling pathway and targeted therapeutic agents 6654 1956 2885 3480 2549 9846 139716 3845 2475 PMC11575928__F2 Survival mechanisms of ovarian cancer spheroids in ascites 4854 1284 3082 100124700 7291 8324 3845 PMC11575928__F3 TAMs in spheroid formation, survival and metastasis 51366 10631 3383 1950 1956 7424 6362 9332 383 6935 999 2875 961 140885 1234 8205 1839 4318 100133941 PMC11576080__F1 Major B-cell signaling pathways and their crosstalk 2695 613 973 974 958 4615 6850 695 5728 7187 7249 5164 5163 6194 572 842 4193 84433 5970 5971 PMC11576080__F2 Therapeutic interventions that specifically target signaling pathways in B-cell lymphoma 5728 4067 973 974 6850 613 695 PMC11576158__F2 Is choline kinase alpha a drug target for obesity? 5465 5468 23411 63976 7350 PMC11576170__F2 Perception and transduction of cold signals in plants 867 23379 83548 PMC11576170__F3 The ICE1-CBF-COR signaling cascade 23379 51411 80119 878 9575 PMC11576170__F4 ROS homeostasis regulates plant cold tolerance 4602 2026 847 6950 PMC11576191__F1 CaMKK2 signaling pathway 2693 10645 8536 814 PMC11576406__F4 Pathways significantly affected by shear stress in HBMECs(A) Effects of physiological shear stress (1 90550 5350 857 858 3270 859 3371 7942 10345 613 5266 3385 3683 3689 3684 3384 100506658 958 58494 5175 3676 3688 90952 3680 1003 2919 6374 4267 6372 3577 3695 3576 6402 2920 947 2921 3579 6403 2734 6401 4283 2833 3627 6373 10666 5817 10563 643 7852 6387 914 965 58191 10663 PMC11576406__F6 Pathways significantly affected by iRBC exposure in HMBECs(A) The endosomal signaling pathway was affected by co-incubation with ring stage iRBCs and shear stress (1 382 6714 3949 1601 387 4087 4088 2060 30846 11021 273 832 998 10890 11311 8723 8411 30844 30845 8724 29934 55737 9798 51534 91782 8027 51160 7251 84313 79643 51652 100170220 6642 27131 2919 6372 3577 3576 2920 100506658 2921 3579 58494 4283 2833 90952 3627 1003 6373 10563 643 5175 7852 4267 6387 58191 10663 PMC11576426__F5 KEGG pathway “Regulation of actin cytoskeleton” (ssc04810) 3630 4018 2147 9965 7852 2149 2245 89846 6010 5829 7414 324 10152 2934 PMC11577197__F1 CD8+ T cell differential hierarchy upon antigen exposure 1236 9760 10219 969 8320 201633 PMC11577197__F2 Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis 941 940 951 201633 9760 8320 10538 3662 PMC11577739__F9 Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPARG /FDX1 signaling 538 2230 1737 59 860 650 PMC11577950__F7 Metabolic pathway diagram of lysosome and autophagy pathways of DEGs after knockdown of HlDnmt1 and HlDnmt in Haemaphysalis longicornis 5641 2717 2548 3425 4668 4669 2990 2581 3073 2588 2799 3423 6448 53 3988 175 2760 20 23457 1201 9516 138050 54 PMC11577955__F8 Mechanisms underlying the tryptophan metabolic pathway 1644 125061 26 6999 1738 PMC11578537__F7 Iron-dependent hepatic regulation of hepcidin 7036 3077 148738 57817 6774 PMC11580016__F1 AHR signaling 196 6714 405 57491 1545 PMC11580016__F2 The sources of AHR ligands 8942 8564 196 6964 PMC11580055__F7 Mechanism of EE improving secondary brain injury after TBI through the TLR2/NFKB/MMP9 pathway 7097 4318 7124 PMC11580298__F3 Network-based hub biomarker discovery for glaucoma 64077 27115 10667 473 50650 5744 6311 2122 28 114793 1191 2762 55289 51071 23414 169792 64778 23293 PMC11580395__F1 SHH pathways in tumorigenesis and their types (canonical and non-canonical) 6608 6469 50937 91653 1283 51684 891 2736 2737 PMC11580395__F2 Interaction between the sonic hedgehog signalling pathway and other molecular pathways 6469 51684 6608 6422 2736 7248 7249 6009 2737 2932 324 1499 2475 PMC11580480__F8 Summary chart 1956 4485 60485 4087 4088 4092 4089 PMC11580516__F1 Metabolic Reprogramming and Drug Resistance in Breast Cancer 3099 6774 47 2744 2475 6391 64798 PMC11580516__F2 Metabolic Reprogramming of Immune Cells in the Hypoxic Tumor Microenvironment 383 2920 3603 406992 3091 3065 3458 7124 6774 PMC11580516__F3 Key Mechanisms of Metabolic and Immune Modulation in the Tumor Microenvironment 2475 1956 1950 3479 8205 PMC11580516__F4 Molecular Mechanisms of Breast Cancer Metastasis, Drug Resistance, and Target Organ Selection 3553 4313 4318 6387 4015 5281 6347 3479 90865 64806 85480 3565 7908 920 PMC11581872__F8 Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway 56339 57721 79068 596 4170 581 836 PMC11582033__F1 RTK/RAF/MAPK signaling in melanoma and its effects on immune cell activity 673 920 941 942 PMC11582033__F2 BRAF/MAPK pathway 3082 2549 2885 7248 7249 2308 2475 PMC11582033__F5 MAPK/ERK signaling pathway and its role in cancer development 6714 3845 673 5728 207 10000 1846 6774 595 1019 1029 4286 2736 2735 4088 PMC11582033__F7 Combination therapy of melanoma using BRAF, MEK, and immune checkpoint inhibitors 1493 941 942 4893 5163 7054 920 PMC11582033__F8 Druggable targets and therapeutic strategies for melanoma treatment 4893 1493 673 942 2475 920 PMC11583660__F1 Urinary estrogen metabolite before and after values 1543 1576 1545 1312 PMC11583678__F4 Elucidated mechanism of OMVs 324 920 940 4615 PMC11583782__F1 Predicted pathway and gene network in the treatment of AD with Jiawei Qifuyin 842 3553 5566 116 43 4128 3356 3725 4312 6416 1131 1133 581 148 836 1543 2932 5970 1128 2555 2147 1576 7040 5468 6401 2562 1132 1812 154 1544 4843 6532 6256 4846 1129 1135 152 2891 5294 153 3326 5530 2944 2554 4988 5743 4792 1139 5709 240 596 207 6258 5644 6531 779 3458 PMC11584093__F4 Anti-cancer signalling pathways modulated by curcumin, gingerol, and shogaol in cervical cancer cells 1499 581 1956 PMC11584862__F6 Two-step model describes the transition from naïve to primed epiblast and subsequent differentiation 4089 1789 8928 4087 6657 2250 8320 7473 PMC11585094__F7 Potential ferroptosis and osteoporosis biomarkers through TMT proteomics and bioinformatics analysis 7018 6520 23657 9817 2879 1728 PMC11585128__F7 Secondary BAs regulate liver TH17/Treg cell differentiation to maintain NASH tolerance 149233 50943 3156 570 1582 969 7368 6819 916 920 960 10803 8213 7189 1244 2354 3725 6280 2168 4312 25801 PMC11585160__F2 Smad5 Signal Path Diagram 4090 4089 3098 4609 860 3397 3398 3399 PMC11586091__F3 Function of exosomal circRNAs in tumorigenesis 5164 3791 2475 100302116 5208 2186 10972 51773 9219 1870 83478 9100 302 693222 PMC11586091__F1 JAK/STAT3 signaling pathway regulated by circRNAs 51701 6347 6774 693222 PMC11586126__F4 CLACs are most significantly enriched in neurological pathways, including (A) glutamate receptor signaling pathway and (B) axon guidance signaling pathway 2593 22944 6091 7054 6092 430 4656 7546 7547 4760 PMC11586749__F6 Analysis of classical signaling pathways and immune infiltration 71 1236 4086 8726 4801 2186 3662 6934 2353 6722 1788 2260 8626 1958 7023 5090 7022 7025 1385 8462 429 4613 3065 6421 5993 4800 9739 7157 6667 53615 6662 10661 865 1655 9126 4782 1387 23081 8085 4149 4602 1106 6925 7528 3725 6929 23028 3169 1022 5452 23186 2033 25836 4609 5885 8243 5087 4791 2078 1050 171023 5929 1025 10155 1876 6772 6872 6908 6591 4629 1386 2551 83860 10538 604 5914 4000 4790 2308 7376 8805 3720 1051 7706 9682 5469 3054 57680 7975 6886 8553 1105 54880 123169 2624 2146 56981 2113 6613 53335 1024 196 2305 51341 3104 9314 7403 3622 4205 6829 10664 6668 6774 2908 23462 3659 3170 3091 7020 4899 84678 7421 30827 5241 1879 862 864 367 51574 7702 6938 4297 4150 2313 4849 7090 23476 PMC11586797__F1 Mammalian target of rapamycin signaling pathway and its interaction with EZH2 expression in hepatocellular carcinoma: Mechanisms and implications 5163 2475 5728 2146 PMC11587691__F2 Lipid metabolic pathway 948 355 9415 6319 47 3418 3417 3156 55902 27165 PMC11587691__F1 Glucose metabolism in cancer cells 1385 2475 2821 2147 3091 5230 10189 728655 6774 3939 PMC11587777__F1 Immunopathological interactions in tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) 4283 324 920 PMC11588630__F1 AIM2 inflammasome activation signaling pathway 9447 79792 7297 115004 2634 2633 115362 29110 3661 6773 PMC11588630__F2 Other signaling pathways of AIM2 79792 11035 8772 3554 3662 149233 114548 9447 197259 115004 3661 PMC11588630__F3 Regulatory mechanism of AIM2 in inflammatory response 4609 2475 9447 331 58484 3627 2833 3659 PMC11588630__F4 Regulatory mechanism of AIM2 in tumor cell proliferation and migration 9447 2475 6774 PMC11588768__F2 TGP treatment: A TGP regulates the Wnt/Beta-catenin signaling pathway to treat IgAVN 7124 920 9314 4094 2879 351 PMC11589783__F5 KEGG graphical of MAPK signaling pathway32 22944 5966 4351 2002 6722 4149 8195 1616 23118 7124 8717 355 929 1950 3727 7189 994 PMC11589783__F6 KEGG graphical of FoxO signaling pathway32 4089 4088 51701 6502 4485 4193 5728 3630 3643 5163 5164 6774 1950 1956 2885 7874 1017 27040 2290 PMC11591163__F1 Blood–brain barrier is severely damaged during ischemic stroke 23657 118672 4553 55240 2879 3652 6713 PMC11591163__F3 Mechanistic diagram of the Nrf-2/AREs signaling pathway 9817 8452 9588 1728 231 PMC11591473__F4 Detoxification of reactive oxygen species pathway 9973 50507 6647 2877 25828 2936 PMC11591473__F6 Oxidative stress induced senescence pathway 3456 7295 50488 6416 5608 5606 5609 9261 7867 3725 7157 23135 8726 1869 2146 23512 4193 PMC11591633__F3 Post-translational modifications regulating NCC activity in the DCT 130497 65266 65125 51719 26249 8452 PMC11591633__F4 Physiological stimuli that modulate NCC activity 551 130497 65266 65125 26249 8452 6446 1325 3630 PMC11591633__F5 Pharmacological modulation of NCC function in the DCT 130497 65266 65125 6446 846 26249 8452 PMC11591698__F1 General Hippo signaling pathway 10207 154796 1499 960 4771 4485 6010 60485 26524 9113 5784 23513 7004 8463 7005 7003 4018 PMC11591698__F2 IPA ingenuity pathway analysis: IPA is a software application used for the analysis and interpretation of YAP’s complex biological interactions in cancer development 23418 79633 9414 23513 PMC11591698__F4 Hippo pathway 4771 4485 7018 60485 23513 PMC11591759__F1 Two possible options for the interaction of Notch signaling pathway targets (Hes1, Hey1) with Runx2 3280 23462 860 PMC11591759__F2 Tissue-specific effect of the Runx2 transcription factor and its associations with various signaling pathways and target genes 3560 860 22943 4155 4359 PMC11591849__F1 Impact of metformin on cancer-related signaling pathways via AMPK activation 7249 2475 8408 2932 3480 595 3667 PMC11591849__F3 The diverse mechanisms through which anti-diabetic pharmacotherapy may affect tumor microenvironment dynamics 3576 3383 114548 6774 6347 3627 8205 PMC11591885__F1 Action of Leu and its metabolites 8140 51520 83667 100682260 207 587 7249 7248 51256 6198 1978 PMC11591885__F2 Leu supplementation leads to tumor cell death by inducing apoptosis and oxidative stress 3479 207 3620 PMC11591922__F3 Mechanisms by which fasting or fasting-mimicking diets kill cancer cells in solid tumors 100187761 3480 2308 3479 10533 60673 9776 8408 2475 23410 PMC11592033__F1 Image depicts a signaling pathway where neurotransmitters bind to membrane receptors, activating G-proteins and effector proteins to produce second messengers like Ca2⁺ and cAMP 3727 3726 2354 PMC11592674__F6 Simulated microgravity effects on transcriptomic profile of bone marrow cell culture 10207 154796 64398 10413 122786 6788 9113 26524 4485 60485 84962 126374 6714 8994 836 4211 1490 8642 79633 4026 4771 3689 249 8463 860 5803 10971 PMC11592687__F1 Core components of the Hippo signaling pathway and their upstream regulators 4771 60485 4485 6010 26524 9113 PMC11592687__F2 Hippo signaling pathway in ROS production 4485 26524 9113 2308 PMC11592687__F3 Oxidative stress activates Hippo signaling pathway 9817 4771 4485 9113 26524 4734 PMC11592827__F6 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study 2066 4193 5915 840 7421 3718 834 2100 10062 2167 3558 4846 3643 2932 2260 2944 4318 1728 4313 6772 6714 336 6256 998 208 2171 2885 207 5170 331 1956 4314 2950 836 3717 2099 PMC11592827__F13 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study 1977 7248 6009 2475 7249 1975 5879 613 6850 930 951 5934 5728 572 4193 PMC11592827__F14 Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study 5360 1581 4023 1376 4312 7350 3611 5163 7316 364 PMC11592846__F4 Lactic acid in macrophages during inflammation as a signaling molecule 159963 160728 4318 6774 7422 383 PMC11593047__F3 Contribution of Sox17-induced gene products to the maintenance of the hematopoietic capacity and cluster formation 4851 90952 3280 64321 54345 2624 2932 861 4087 4088 7046 83595 2623 PMC11593353__F2 Differential Gene Expression Associated with Idiopathic Epilepsy in Belgian Shepherd Dogs 10379 6772 6773 PMC11593403__F10 Characterization of phenotypes in melanoma cell populations resistant to dabrafenib or AZ628 558 673 23788 595 890 2495 2879 23657 PMC11593441__F4 Signaling pathways regulating macrophage (Mφ) polarization 7099 114609 4851 729230 4615 6772 7187 7189 6778 1636 2475 3661 6774 383 3663 3586 PMC11593954__F5 Comparison of neuro-regeneration mechanisms in the peripheral and central nervous systems 1499 627 1000 1270 2475 6469 6010 PMC11594113__F1 Insulin-like growth factor 1 signaling pathway 2475 4193 572 PMC11594131__F5 Possible ways of protective action of MKs and MKT in signaling and metabolic pathways under oxidative stress and heavy physical exercise 23411 4899 5465 2475 5166 65018 PMC11594159__F1 Redrawn from WSP268, the version of the Notch signaling pathway depicted on Wikipedia https://www 9794 55534 1855 1856 1840 1387 3955 1857 113878 8650 4242 196403 9253 5986 23220 151636 28514 4851 10683 4853 54567 4854 4855 182 83464 3714 7124 5664 8756 23385 3280 388585 171558 9612 3065 1487 1488 3066 PMC11594203__F6 Differentially expressed genes related to mammary epithelial cell proliferation and milk protein synthesis in the PI3K-Akt, WNT, and mTOR signaling pathways after knockdown of S100A9 in MAC-T cells 4040 6280 7099 1857 7249 206358 28956 2475 64798 2309 595 983 1017 PMC11594236__F1 Cellular mechanisms involved in OA synovitis in osteoarthritis 4322 6347 6352 6348 6279 PMC11594238__F4 Hormone synthesis and signal transduction pathways 238 4691 4015 2077 1879 64641 8205 1362 PMC11594620__F1 Metabolic pathway of complex sphingolipids in budding yeast Saccharomyces cerevisiae 5004 5005 1442 PMC11594856__F1 Signaling pathway of CTLA-4 941 942 940 PMC11594976__F7 Differential expression of hormone signaling pathway genes in PhARF5- and PhARF19a-silenced petunias 51411 578 108348016 7018 4881 1879 64641 PMC11595439__F3 The CWI signaling cascade 8161 55288 6667 116844 466 4156 PMC11595909__F1 Effects of BDNF and NGF on the cell signaling processes that potentially lead to cellular effects with the end results of neuroregeneration or neurorepair 4803 627 5163 PMC11595909__F2 Signaling mechanism of IGF-1 upon binding to IGF-1 receptor (IGF-1R) 3479 3480 5163 2475 572 PMC11595909__F3 LIF signaling mechanism upon binding to LIF receptor that is constituted by LIFRB and gp130 heterodimer 3976 3977 2475 PMC11596539__F3 UV damage and EGCG repair of collagen network layers in photoaged skin 1956 4087 4088 PMC11596795__F5 Metabolic pathway and relative abundance of key genes of DAMO bacteria (a–c) and DAMO archaea (d–f), with predicted metabolic function as recorded in KEGG 7086 4548 4524 PMC11597433__F4 Wnt signaling pathway [04310] 54894 51701 147111 9350 84445 4041 4040 324 4089 23411 50964 4088 25805 57805 4163 PMC11597542__F2 TLR and RLR signaling pathways and LNP effects 51284 54106 51311 7189 4615 57506 3661 3569 2919 3586 3606 PMC11597624__F1 Secondary metabolites in invasive weeds, for the synthesis of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), methylerythritol phosphate (MEP), and mevalonate (MVA) pathways responsible 9961 4597 3652 PMC11598538__F3 Metabolites and DEGs in the biosynthesis pathways of fatty acid derivative and terpenoid in Oncidium Twinkle ‘Red Fantasy’ 4015 4598 9961 3423 3652 PMC11598704__F3 Role of deubiquitinating enzymes on the cell cycle in GC 10713 10868 8975 57558 57663 57695 4485 60485 9960 26524 9113 55593 219333 55611 8239 56957 25862 5682 PMC11598914__F2 Various interactions between RABV proteins and interferon signaling pathway 3665 29110 3661 5371 6773 10379 6772 3659 9636 PMC11598946__F5 Some of the respiratory syncytial virus’s immune-evading mechanisms 7098 7099 4615 3661 57762 57506 64127 PMC11599025__F1 Innate immune responses against ASFV infection 114548 7099 7187 3716 7297 3717 115004 57506 51284 7098 51311 3661 10379 6772 6773 PMC11599189__F2 Figure illustrates the various functions and molecular interactions of circFOXP1 in cellular processes 2475 1786 10765 6774 5725 9242 PMC11599216__F4 Crossroads of epigenetics and immune pathways 5253 4615 56339 7189 10765 8242 54790 3661 2146 PMC11599537__F3 TLN1 in cancers 100302284 2147 2152 1020 7094 PMC11599740__F2 Activating insulin growth factors and energy deprivation triggers the HIF signaling pathway 92335 6009 2885 7248 7249 3667 4763 8473 5163 7428 6010 PMC11599795__F1 Hippo signaling pathway is a key regulator of cellular and systemic metabolism, maintaining organ size and tissue homeostasis by controlling cell proliferation, survival and regeneration 4485 60485 26524 9113 10413 PMC11600033__F12 HA/PEI-RH NYPs for UC treatment 594857 960 4615 PMC11600669__F1 Signaling pathway according to KEGG (A) NAFLD and (B) PPAR 619501 831 335 4023 1363 3611 PMC11601888__F4 Function analysis of the high-confidence functional lncRNAs 2247 4838 652 4087 4088 4089 1499 6657 7012 79923 7454 6418 5901 10763 PMC11602063__F15 ROS promote ginsenoside biosynthesis under water stress 3156 3652 847 8213 PMC11602425__F1 Metabolic reprogramming of tumor cells 3099 2539 3939 PMC11602425__F2 Metabolic reprogramming drives HCC progression 2475 5079 10320 2539 5226 4609 3099 57103 2147 3939 6472 5163 3418 2271 23409 7295 56961 2744 PMC11602425__F3 Metabolic reprogramming drives MASLD progression 6774 114548 80339 7015 58191 6373 2475 PMC11602477__F2 Notch signaling pathway in CSCs (By Figdraw) 4851 4855 4853 4854 PMC11602477__F3 Hedgehog signaling pathway in CSCs 6469 5727 6608 51684 2735 2736 PMC11602941__F2 TGFB family signaling pathway 4838 4092 4087 4088 4089 4086 4090 4091 PMC11602941__F3 TGFB family signaling in human pluripotent stem cells 4838 4087 4088 6657 4089 79923 4086 4090 PMC11603026__F4 Drug repurposing discovery in Mpox infection 2033 1398 619410 10538 PMC11603026__F5 Mpox’s role in antiviral and proviral cell signaling regulation 7054 100187907 115004 84188 355 6101 PMC11603026__F6 Mpox manipulation and activation of proviral signaling via AKT, Wnt, and STAT3 signaling pathways 6774 7186 3656 3725 367 2932 581 29110 1019 572 355 3661 28996 9021 4513 PMC11603363__F1 Pyroptosis pathways 56169 3002 3001 79792 55876 PMC11603363__F2 Pyroptosis and the role of immune and non-immune cells in asthma 114548 79792 9447 7099 6772 58484 22900 22861 PMC11603636__F7 Schematic mechanisms concerning the IRE1Alpha-XBP1 axis in LPS-induced acute lung injury 7494 10628 114548 PMC11603854__F1 Current concept of the signaling pathway underlying the Beta-adrenergic regulation of CaV1 1431 875 1638 PMC11603874__F4 TNFR2/Mb-TNFA signalosome pathway 7186 1540 5728 660 5208 81858 7189 6890 6891 8829 4582 1499 1956 2475 4513 7852 6387 6774 3479 3371 4318 6364 80312 10682 5971 PMC11603874__F6 TNFA/TNFR2-mediated invasion and metastasis in BC TME 920 7291 1956 6774 3082 6347 3577 3579 729230 7852 PMC11603874__F7 TNFR2 supports BCSC growth and development 1956 331 6591 6657 7186 6774 55704 961 3091 960 4609 PMC11603874__F8 Signals from Mb-TNFA/TNFR2 stimulate HIF-1A, CXCR4, and PD-L1 1956 3725 4609 7852 607 6774 6955 7428 468 961 6387 5966 4942 PMC11604295__F2 Functions of TDEVs in tumor progression 9242 3845 1956 5214 3099 2539 226 7086 6888 100 PMC11604586__F1 Progress and perspectives on BMP9-ID1 activation of HIF-1A and VEGFA to promote angiogenesis in hepatic alveolar echinococcosis 3397 7422 2475 51564 PMC11604654__F4 Two signaling pathways that Fish oil and Forskolin involved23–25 4513 3643 6770 3949 1588 2492 9210 654 PMC11604675__F1 Fusobacterium nucleatum facilitates the metastasis of CRC via modulating the expression of FadA-Wnt/catenin signaling cascade and NFKB/TLR4/MYD88 signaling pathway 7099 4615 999 1499 100302166 595 6364 PMC11604893__F1 Tumor energy metabolism: implications for therapeutic targets 693188 2475 2597 5132 5315 3939 PMC11604893__F3 SWI/SNF complex regulating tumor metabolismThe purple gene and arrow represent glucose metabolism 2194 47 6597 6595 1373 6604 6319 5468 2203 3939 5214 5315 51 PMC11605246__F8 Schematic explanation of the mechanism of action: the transformation into M2-like of spleen macrophages in patients with PH is activated, which in turn activates the Ras-Raf-MEK-ERK-c-Myc signaling pathway axis 3565 3596 3586 948 9332 PMC11607510__F3 Glucose metabolism reprogramming of VECs 2646 3098 5209 4047 3099 5292 2147 7412 3939 PMC11607510__F4 Glucose metabolism reprogramming of VECs in atherosclerosis 3949 5562 3383 23410 5209 7412 1000 387 9474 2475 5163 57103 1003 6093 PMC11607693__F1 Genome engineering Drosophila TGFB/BMP signaling 100188011 4087 5199 2821 23170 387582 6678 PMC11607765__F1 Clinical role of Aldehyde dehydrogenase-1A1 (ALDH1A1) in pancreatic cancer 6714 2932 216 PMC11607912__F3 Differentially expressed genes and DNA (hydroxy)methylation levels within the TRP metabolic pathway and NAD pathway 26 1571 93100 4860 8140 169355 23475 23057 1718 2806 56267 142 55191 65220 143 23411 23498 55526 1738 22978 56953 1582 PMC11607912__F6 Gene regulatory network (GRN) of TRP and NAD pathway 6520 216 39 1573 847 219 8140 2639 1576 38 1743 4129 1543 4128 1571 1738 3620 169355 23410 83666 10135 23411 54625 142 5743 1544 22933 1962 217 8854 51547 4967 23475 952 51548 5740 PMC11608335__F1 Using Z. mobilis as the chassis for biochemical production 7498 718 3652 5132 717 727 10278 PMC11608501__F11 Proposed schematic describes the mechanism of TRPM7-induced pyroptosis in SE 54822 6774 3717 79792 114548 PMC11608829__F6 miRNAs and circRNAs role in pathogenesis 619501 27250 1050 PMC11609662__F8 Metabolic pathway map of detected metabolites 4975 355 95 PMC11609686__F1 Illustration shows the suggested role of SARS-CoV-2 in EMT induced by ROS in cancer cells 8829 59272 114548 2475 6935 558 PMC11610194__F7 Regulatory networks of critical pattern pathways 50964 7480 7475 6424 22943 7976 11211 6502 2937 2877 890 1499 90381 2936 79094 1501 4998 990 51176 51056 627 2323 2255 80310 7422 23529 4915 3576 3570 5159 3815 2784 3716 1230 1235 7535 6850 3667 775 776 27040 5290 5295 6261 5335 10000 5581 2185 91860 5519 5588 84699 2934 65108 85477 84433 114 3551 598 596 896 5970 316 7185 7128 PMC11611192__F8 The signaling pathway by which high glucose participates in the GEnCs injury via the RXRA/circ8411/miR-23a-5p/ABCA1 pathway 6256 19 79792 PMC11611323__F2 Metabolism of AdA 60481 100 4015 1628 3929 PMC11611323__F3 Action of AdA in NAFLD 100 948 2876 920 3002 PMC11611719__F7 Schematic model indicates that ozone promotes macrophage efferocytosis and alleviates neuropathic pain 6868 9021 2621 10461 PMC11612265__F3 Glycolytic reprogramming in macrophages orchestrates NLRP3 inflammasome activation in ALI/ARDS 114548 2147 5209 PMC11612265__F1 Possible activation mechanism of NLRP3 inflammasome 57506 114548 79792 7099 8772 PMC11612504__F2 Role and mechanism of the EGFR/MET-mediated signaling pathway in cancer cells 3082 1950 1956 5728 2475 2932 572 PMC11612565__F2 Effect of DAMPs on vascular ECs during sepsis or severe bacterial infections 3146 1003 114548 PMC11612565__F3 Specific pathophysiological mechanisms of EC apoptosis in sepsis 581 2549 9353 5292 55000 106182249 100126354 406991 6774 6093 27230 54434 8828 2475 PMC11612565__F4 Mechanisms of EC pyroptosis in sepsis 79792 115004 114548 7099 1667 1668 574045 6761 90865 3146 PMC11612565__F5 Mechanisms related to ferroptosis of ECs in sepsis 9817 26872 2879 10644 467 6382 23411 50507 10220 PMC11612565__F6 Relationship of EC autophagy and function and EC autophagy-related mechanisms in sepsis 8542 23411 114548 1003 4282 972 5725 6502 860 2475 100126297 10135 10533 PMC11612781__F3 From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling 5187 7432 3164 1407 2554 551 60675 128674 1959 1958 2885 PMC11613313__F2 Endometrial Receptivity Affected by Fibroids 650 133 659 4086 4089 3206 3207 PMC11615404__F10 Fisetin on ferroptosis and oxidative stress in glutamate- and erastin-stimulated HT22 cells and rats after TBI, which may involve the PI3K/AKT/NRF2 pathway 6520 55240 2879 2512 8031 PMC11615452__F1 Wnt signaling pathway 324 23002 1499 6010 998 595 51701 PMC11615452__F2 Therapeutic strategies targeting Wnt/Beta-catenin signaling 1499 11197 6424 22943 PMC11615488__F5 Map of phospho-proteins in cellular signaling pathways that regulate YPP expression in mosquito fat body 7248 7249 6009 2475 5728 253260 5861 7405 8650 7791 342371 23513 9711 8897 596 64422 9140 PMC11615816__F6 PGRN Inhibits B‐cell Activation and IgE Production through the PGRN‐IFITM3‐STAT1 Signaling Pathway 2896 10581 1637 930 100187761 952 4280 PMC11616179__F1 Liver macrophage in the initiation and progression of liver fibrosis 6347 729230 6346 1237 6352 1234 7124 114548 3146 4017 4318 PMC11616179__F2 Liver macrophages in liver fibrosis repair 6774 4318 4321 4322 PMC11616179__F3 LAMs and LCMs in liver injury 1524 729230 54209 114548 9927 PMC11616203__F3 Effect of TRPM channels on signal pathways related to tumor progression 4308 1956 54795 54822 7226 2475 1499 4193 5728 10399 3091 898 5111 1017 79054 PMC11617210__F10 ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1A/PPARA pathway: integration of WGCNA, machine learning and experimental validation 154 23411 5465 6347 3576 3627 PMC11617408__F5 Apoptosis: Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) initiates cell death through two mechanisms: direct caspase activation or indirect activation via the release of apoptogenic factors from mitochondria 7124 355 8717 8772 7186 PMC11617408__F6 Activin and BMP signaling pathway 4087 4088 4089 4086 4090 PMC11617596__F4 Ac4C‐related signaling pathway in cancer 108348016 1499 55226 595 1000 999 PMC11617596__F3 NAT10 plays a critical role in cancer 55226 22983 7020 2305 79026 4286 55139 1051 91746 2342 558 4854 PMC11617665__F1 Metabolic signaling pathways modulated by PTP1B 5163 5728 3717 3667 6774 PMC11617869__F2 SSA significantly impacts cancer by inhibiting cell proliferation, inducing apoptosis, suppressing invasion, reducing cell growth, and alleviating skin toxicity 2475 1956 50507 6714 581 7852 572 2638 PMC11618000__F8 MST2-mediated Hippo signaling pathway involved in T 7004 8463 7005 7003 9113 PMC11618518__F1 Molecular mechanisms of tissue fibrosis 90865 6010 5970 2475 4087 4088 4089 1499 717 PMC11618518__F4 Macrophages in organ fibrosis 7124 3553 6347 729230 3597 7448 4087 4088 PMC11619108__F2 Cnetplot of enriched pathways of DRPs identified through REACTOME analysis 55193 55170 6883 9611 11091 9739 8089 5928 23135 23028 23522 10902 8242 6603 8518 23186 6597 57492 6599 22992 54815 6595 9219 1107 6605 9112 1108 79718 23774 94239 196528 4629 8295 998 55352 808 805 56943 5058 6010 84661 79595 4627 55578 801 3054 8473 9643 10498 6598 10524 6601 1788 9612 6907 3014 112869 53615 5063 6602 25855 8819 3065 5062 4637 10398 PMC11619108__F3 Cnetplot of enriched pathways of DRPs identified through KEGG analysis 81873 1073 10095 1398 8877 10096 57180 2934 3635 5578 1072 10094 5581 382 10092 5880 4067 10093 4082 10109 10097 4690 3845 998 10451 5058 7409 5894 5293 387 868 5530 2932 5063 7535 5062 5515 55844 5518 2534 8440 3937 5522 3304 3320 3326 3458 2923 3308 3123 3126 4801 567 3303 5720 3134 3122 3312 3105 3305 3309 3115 6892 3306 3118 PMC11619119__F2 Key IFN signaling pathway targets disrupted by HBV components 3454 3455 7099 4615 7187 81030 57506 29110 3665 3661 7098 51284 51311 9021 3654 51135 8651 3716 7297 6667 6670 6668 6772 6773 4599 4600 3434 9636 6041 PMC11619421__F6 PPI network of associated pain-related genes enrichments in KEGG pathways and tissue expression 4609 23291 51176 8313 7474 1499 27130 8321 1855 4846 50944 4920 779 8911 818 7483 5153 3708 109 9630 54361 8322 196883 2778 8326 3360 5141 5170 1816 1129 5154 2065 146 148 6844 10716 10681 793 1958 6750 2562 2895 1392 6185 2353 6184 116444 2901 9463 2668 6336 4914 163 2247 10215 23426 1759 2817 8871 274 3631 23396 63827 5457 338917 551 1938 6229 1267 PMC11619685__F1 Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration 7124 8772 847 597 572 637 22926 581 PMC11619685__F2 Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration 114548 79792 1687 PMC11619685__F4 Activation of the p38 MAPK-mediated senescence pathway can occur because of pH changes or stimulation of ASIC1 or ASIC3, which initiates the ATM/ATR pathway 9311 41 545 472 23411 1017 2475 1021 1019 PMC11620105__F7 Distribution of key targets in the PI3K/AKT signaling pathway 2475 1977 6009 7249 1975 2885 3667 5879 6850 613 930 5934 5728 572 4193 PMC11620636__F7 LncRNAs induced by SARS-CoV-2 can exert cis-regulation on the IL-27 pathway 100187761 3716 3717 109729169 6772 51311 10148 51135 3654 3656 3665 3661 2354 3725 4791 114614 400759 100506178 8638 3620 4940 2633 3593 6348 7124 3569 80149 115361 91543 3627 1437 3458 1435 115362 7039 400941 PMC11620901__F4 ACL injury management: a comprehensive review of novel biotherapeutics 1950 4087 4088 387 7249 4089 5058 5062 PMC11621219__F4 Immunostimulants regulating adaptive immune responses by activating TLRs 7096 7097 10333 7099 7100 54106 7098 4615 3665 3661 3586 PMC11621238__F4 Mitochondrial dynamics and mitophagy in GBM cells 10131 10981 27185 55669 9927 664 9314 65018 23786 729533 PMC11621763__F4 C-Myc/Max signaling pathway 8772 4609 4149 637 581 PMC11621776__F4 Important AM pathways 7851 11113 4118 355 PMC11621778__F9 Multi-omics co-analysis 8877 9517 56848 718 146 5027 136 2914 151 7200 948 29904 5522 5105 7040 183 4829 8620 7432 2560 6774 1387 8482 23682 79132 10537 655 4086 283078 1277 9636 345611 6591 3036 8648 101 85301 57761 220296 54900 55601 1284 115361 1278 4087 1282 11274 81030 3665 3569 55679 790 376497 22884 PMC11621799__F4 Pathway activation in ACO and COPD identified through KEGGpathway enrichmentanalysis 7099 6774 9978 7428 8453 2056 7018 7037 2475 5163 2597 226 3939 260431 7124 9825 8717 8772 1540 2752 355 3466 27005 81030 7098 4015 197259 637 114548 3014 5447 90865 PMC11622572__F7 Signaling pathway analysis of genes in cluster 5 using KEGG database (A) Gene expression profile during functional unloading (B) Heatmap of DEGs with p 5360 3157 345 336 335 116519 948 2167 28965 6256 2171 4023 2168 4973 10999 6342 5346 51 729359 1962 33 1376 51129 9370 10580 PMC11622655__F1 Effect of Triolein on brain damage after ischemic stroke 3586 3569 2475 PMC11622859__F4 Reconstitution of the biosynthetic pathway of CNs in this work and the semi-synthesis of ISIR-050 3652 108353830 108383235 1257 1255 PMC11624271__F2 General signaling pathway of CLRs from Dectin-1 and Dectin-2 clusters 387837 283420 6850 5894 695 64170 10892 8915 PMC11624276__F8 Schematic diagram displaying the role and mechanism of GPR160 in bone cancer pain 6667 26996 4311 PMC11624796__F7 Natural lung-tropic TH9 cells: a sharp weapon for established lung metastases 7189 6387 7852 83737 8205 PMC11624815__F9 Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity 961 5066 920 PMC11625190__F1 Biosynthetic pathway of 1-phenylethylisoquinoline-derived PIAs 780904 1644 131 PMC11625754__F4 Effect of AB on the NMJ formation process 351 4038 4593 PMC11625809__F1 Neuroendocrine Evolution and drug resistance mechanism of prostate cancer 367 105373241 100124700 64595 400960 26255 283120 100507008 154822 378938 724102 140828 PMC11625809__F2 LncRNAs are involved in the neuroendocrine secretion of prostate cancer 154822 283120 140828 100507008 367 10397 6774 103504737 84733 1499 PMC11625809__F3 LncRNAs are involved in the AR pathway to regulate enzalutamide resistance 400960 3190 100124700 367 4193 23326 378938 PMC11625861__F1 The HS biosynthetic pathway 64131 64132 11285 126792 2137 2131 2132 26035 9653 PMC11626610__F4 Genes from the Toll-like receptor signalling pathway remain differentially expressed 8 h post 4th dose in MAD cohorts 7096 7097 5879 10333 54472 7124 8772 114609 3929 929 4615 23118 51135 7099 5132 1513 54106 7098 3665 3661 7187 958 PMC11626780__F3 Glutamine interconversions and metabolic pathways 440 5723 5625 29968 PMC11626780__F4 Urea synthesis pathway involving arginine and PRMT-mediated FLT3 arginine methylation 445 435 2731 2322 23081 PMC11626780__F5 Immunosuppressive pathways involving tryptophan 23428 3620 6999 120103 PMC11626780__F6 Intracellular metabolic pathways of BCAAs and the mTORC1 signaling pathway 586 6009 3091 6198 7942 8408 84271 PMC11626976__F2 Interaction role between TRIM family and Akt signaling pathway in GI cancer 8805 5728 286827 5987 5163 22954 9830 54765 PMC11626976__F3 Interaction role between TRIM family and Wnt/Beta-catenin signaling pathway in GI cancer 81559 89870 23650 8805 10498 324 10155 22954 1499 135892 25893 595 4316 PMC11626976__F4 Interaction role between TRIM family and STAT3 signaling pathway in GI cancer 23650 5987 9866 9830 6774 84851 8877 4313 4318 PMC11626976__F5 The TRIM family in the TGFB signaling pathway in GI cancer 7706 4087 4089 4088 91107 6359 PMC11626976__F6 Interaction role between TRIM family and p53 signaling pathway in GI cancer 7706 373 4193 440730 10155 8805 286827 22954 56658 10612 PMC11627363__F7 Golgi apparatus stress response pathway activated by AIV infection 7030 10402 523 4247 PMC11628441__F1 MTOR signaling pathway in astrocytes (simplified scheme) 5728 7248 7249 6009 3643 3026 PMC11628519__F3 Molecular mechanisms of the JAK-STAT pathway in CRC cell proliferation, apoptosis, migration, and invasion 6778 7421 6774 387 4609 23476 472 PMC11628531__F1 LAG-3 signaling pathway and its ligands in tumor immunity 324 2267 3902 920 6868 102 PMC11629350__F6 Neural graph network displaying the six signaling pathways that were detected as significantly regulated, along with the genes within these pathways that were significantly affected by mechanical loading (0 410 782 123720 100188776 9612 6517 364 23370 PMC11629383__F2 Truncated yet functional NOTCH2NL genes 4853 28514 3565 4609 PMC11629383__F3 POU5F1P1 and NANOGP8, two processed pseudogenes encoding functional proteins 414134 126669 340217 349372 414131 3006 414135 79923 26291 374 6774 999 PMC11629464__F1 MiRNA regulation of apoptosis and autophagy in Mtb-infected macrophage 7099 929 114609 4615 8651 51135 207 3654 572 6772 7189 6009 2308 2309 10454 23118 604 637 581 7942 2475 3458 7124 PMC11629574__F8 Schematic diagram showing the yes-associated protein 1 (YAP1) as a critical molecular pattern for diabetic kidney disease (DKD) 4485 26524 9113 10413 3569 6372 2919 65018 7019 6363 PMC11629812__F6 S‐Nitrosylation of NOTCH1 Regulates Mesenchymal Stem Cells Differentiation Into Hepatocyte‐Like Cells by Inhibiting Notch Signalling Pathway 4851 3280 182 PMC11631473__F2 Metabolic pathways for anabolism and catabolism of DAG in model yeast Saccharomyces cerevisiae 4099 2195 5091 PMC11632373__F1 Biosynthetic pathway of GPI-APs 2822 58986 5277 5279 5283 51227 9091 84992 64801 8818 9487 81037 84302 27315 93210 8705 80235 284098 93183 55650 23556 9488 54965 84720 5281 94005 10026 80055 54872 51604 128869 PMC11632667__F3 1) BMPs activates the SMAD pathway, which increases inflammatory cytokines VEGF, tumor necrosis factor alpha (TNFA), and Interleukin-6 (IL-6) 4089 4086 4090 4091 9242 PMC11633002__F3 Network constructed based on the interaction test within the small cell lung cancer pathway from KEGG 7157 3913 208 PMC11634591__F1 CGAS-STING signaling pathway 115004 3661 3665 PMC11634591__F2 cGAS-STING pathway plays a significant role in mediating cardiovascular disease 217 115004 79792 26524 9113 29110 10413 3661 11277 4485 3383 PMC11634591__F3 cGAS-STING pathway plays a critical role in mediating obesity in adipose tissue 7099 5140 29110 3661 115004 PMC11634591__F4 cGAS-STING pathway in the liver plays a key role in mediating NAFLD/NASH/ALD 7099 115004 29110 3661 PMC11634819__F8 Schematic diagram illustrating the signaling pathway through which A‐MG influences hypertension, hypertension‐associated vascular remodeling, and changes in uric acid levels 1636 1264 59272 PMC11635172__F2 Related pathway mechanism of pyroptosis, necroptosis, and ferroptosis in the occurrence and development of ALD 10628 114548 79792 11035 8737 8031 197259 2879 64778 23657 6520 PMC11635172__F3 Molecular mechanisms of the immune response are involved in the progression of ALD 3553 7099 3576 2919 3934 PMC11635231__F2 Importance of FXR in the enterohepatic circulation of BAs 1581 64240 64241 3172 1582 1593 9420 570 25801 2264 9965 PMC11635231__F3 FXR in four lung diseases 115761 1728 2729 7124 3606 6615 6591 1950 1956 6774 3717 3572 PMC11635239__F8 LPS induces the upregulation of activin-A in recAMs, which can drive the EMT process by activating the TGF-Beta-SMAD signaling axis 3624 4087 999 PMC11635611__F2 Morphine tolerance-related signaling pathways inside microglia 627 5159 7099 114548 1956 PMC11635611__F3 Crosstalk among microglia and astrocytes with neurons 3627 2833 627 114548 PMC11635660__F2 Transcriptomic analysis of dietary G 1036 47 9514 3033 27293 3638 PMC11635689__S1 Metabolic Pathway of Conversion of 5-ALA to Protoporphyrin IX in Gram-Negative Bacterial Cells 3145 7389 2235 PMC11635874__F1 TGFB signaling in bone 7939 4087 4088 10454 4092 4089 64750 PMC11635874__F2 BMP signaling pathway in bone regeneration 26585 10454 4090 4086 4092 4091 57154 4089 860 1749 PMC11637887__F3 Comparison of changes in the eye among normal, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR), and the signaling pathways of DNA methylation alterations associated with DR development 54790 1786 5879 5465 7076 PMC11637887__F6 Impact of DNA Methylation on Schizophrenia 2571 1786 1312 1392 1268 2908 PMC11637887__F7 DNA methylation changes in the pathogenesis of HD and the cellular impact of toxic huntingtin protein variants 328 672 6117 6119 627 79923 6657 4478 PMC11638059__F3 Few molecular mechanisms by which TAM affects EC 6367 1233 7422 4318 6280 6279 PMC11638062__F2 Examples of protein ubiquitination and their roles in ovarian cancer 55553 26270 26232 8635 25777 157574 8452 54822 10213 23092 3091 PMC11638062__F3 Examples of protein phosphorylation and their roles in ovarian cancer 1017 2241 5164 55872 1956 23235 8471 3607 4591 4638 5296 5728 4633 2475 PMC11638311__F4 Metabolic pathway of sphingolipids 171546 10558 9517 204219 91012 29956 79603 10715 8560 123099 81537 130367 56848 64781 PMC11638432__F6 The mechanism of PTX3 regulation of innate immunity and ferroptosis after LPS challenge 5806 6364 1235 PMC11638488__F7 Mechanism of Trp in alleviating MS 1581 1582 1593 8213 9420 2264 9965 PMC11638664__F6 Schematic synthesis of data and hypothesis 55366 8549 1956 324 474 1499 PMC11639970__F1 WNT and TGF-Beta Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Populations 324 3725 6010 2885 2475 PMC11640042__F1 Wnt signaling pathway 4041 4040 324 6259 1499 51701 PMC11640042__F2 Wnt signaling regulates HCC biological behavior 55859 2048 864 6935 100126333 693224 55521 1021 442909 6665 8932 4670 378938 100885779 10626 57159 6925 51701 6664 51474 5243 11211 PMC11640042__F3 Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities 6422 324 1499 140628 4041 4040 4071 PMC11640101__F1 Metabolic reprogramming in cancer 3098 3099 3939 3156 9961 2194 47 PMC11640101__F4 Involvement of the ARF6-AMAP1 pathway and Arid5a in cancer progression and immune evasion 3091 382 3098 3099 3939 6935 3845 57669 9230 9961 7157 10865 3620 6347 PMC11640331__F1 Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies 6608 5727 51684 2737 2736 PMC11640686__F2 Some small molecules and signaling pathways promoting the development of the nervous system (based on the poster https://www 7045 4838 4087 4089 6608 2475 847 PMC11640686__F3 Chemically induced reprogramming of fibroblasts into neural stem cells and into neurons in the brain and retina [12,36,37,39,41,42,43,85,86] 6469 102723505 4018 627 2668 85457 3479 PMC11640686__F5 Chemically induced reprogramming of ESCs and iPSCs into neural stem cells and into neurons of the brain and retina [2,47,52,54,97,98,99] 102723505 85457 3479 PMC11640686__F6 Chemically induced reprogramming of RPE into neural stem cells and into neurons in the brain and retina [12,27,46,93] 22943 3479 85457 PMC11640812__F2 Crosstalk relationships between signaling pathways 1616 3716 2475 PMC11640923__F2 Intestinal iron absorption (left) and iron handling in a generic cell (right) 7018 9843 57817 7037 8031 22 94033 9927 PMC11640923__F3 Iron homeostasis by cellular iron levels (left) and oxidative stress (right) 9817 6622 2512 2495 351 7037 8878 PMC11640923__F4 Iron handling in the brain 57817 9843 7012 PMC11640923__F5 Pathomechanisms of FTD that might involve iron imbalance 94033 8031 29978 2521 8148 2130 PMC11640972__F2 Tryptophan metabolic pathways 8942 8564 23475 PMC11641026__F4 Biosynthesis of aminonucleosides 1476 1475 4553 PMC11641149__F1 Regulatory factors of mitochondrial dynamics, associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD) 55669 9927 56947 65018 120892 PMC11641392__F2 Notch signaling pathway with Notch and Bcl-2 therapeutic targets in T-ALL 5045 102 572 637 4170 597 5763 PMC11641400__F3 HA35 enriches signaling pathways involved in growth and antioxidant response in the developing murine intestine 140739 7341 4193 6233 3845 9039 7320 2475 7157 PMC11641539__F12 Diagram illustrates the neurotrophic activity of FVSE via activation of the Trk-B receptor in the Neurotrophin signaling pathway 627 4803 2885 596 PMC11641583__F2 YAP activation in KCs 3861 3852 8502 1828 5317 1830 4771 7070 6714 60485 4485 302 81532 26524 9113 374 1956 7004 8463 7005 7003 9314 8289 PMC11641583__F3 YAP and TAZ interactions with signalling pathways and TFs 10664 2521 558 1956 2263 6714 5031 2736 6469 374 23476 4040 2932 1499 4086 4090 4087 4088 4092 4089 51384 10683 28514 7049 6591 9314 9686 6615 PMC11641594__F5 Human papilloma virus infection pathway with differentially expressed proteins (DEPs) 5728 23513 324 3661 8717 8772 572 1017 472 545 7015 1956 2885 6908 7297 6773 8638 8066 PMC11641594__F6 HIF-1 signaling pathway with differentially expressed proteins (DEPs) 7099 3466 6774 7428 8453 2056 7037 7018 2475 1906 5163 5211 226 2597 3939 PMC11641594__F7 Apelin signaling pathway with differentially expressed proteins (DEPs) 4854 5140 10365 4089 4088 PMC11641594__F8 WNT signaling pathway with differentially expressed proteins (DEPs) 54894 51701 147111 25776 9350 324 4089 50964 4088 25805 6500 9978 2040 387 9475 27130 6259 PMC11641594__F9 Protein–protein interaction (PPI) performed by Ingenuity pathway analysis (IPA) 1956 710 2160 3700 57291 56833 3963 337 2161 462 3698 715 7472 9370 23024 23052 23184 27346 79834 219287 7094 8618 2705 7145 26045 6518 23242 83987 105373767 5829 79073 3001 57662 6187 10439 4633 2184 51499 10133 147906 2590 6155 10944 10297 11014 51309 23650 7840 283431 2078 6772 6935 9749 3170 5970 6774 7089 4088 79923 7157 56892 3091 9141 55139 4208 8928 6872 8379 595 81669 103 23493 148398 129685 83719 PMC11641605__F3 Intracellular signaling regulation of the ECM signal transmission 7410 5163 26524 9113 4485 60485 PMC11641605__F5 Hypoxia regulates intracellular signaling through multiple mechanisms 6010 4485 9113 2056 PMC11641605__F6 Crosstalk of ECM and hypoxia in the Hippo signaling pathway 154796 4485 60485 6010 84962 999 26524 9113 122786 10207 2066 6910 1958 PMC11641610__F3 Key signaling pathways involved in T cell senescence within the tumor microenvironment 3135 7535 7015 472 2475 PMC11641910__F1 Network of protein interactions involving p21 in diverse cellular processes 7251 6418 6774 5111 4193 91768 PMC11641910__F2 Various metabolic pathways involving p21 1950 1956 2539 57103 6236 PMC11642109__F1 Schematic illustration showing the effects of the sympathetic nervous system (SNS) and the renin–angiotensin system (RAS) on cancer development 59272 183 5906 2475 2623 6774 PMC11642419__F2 PRV evades the TLR and RLR signaling pathways 7099 57506 29110 7187 3661 3665 7097 7100 4615 7098 51284 54106 7189 PMC11642419__F3 PRV evades the DNA-sensing signaling pathway 9690 115004 54472 3428 3661 29110 PMC11642419__F4 PRV evades the IFNAR–JAK–STAT signaling pathway 3455 7297 6773 10379 2056 7726 9636 3669 4599 PMC11642960__F4 Pathway and network analysis of the proteins identified in the AR/SRF interactome 27043 6722 3169 1499 367 9451 3309 3320 7184 2597 7167 2288 11140 196 2064 1019 2908 3845 7015 4117 PMC11642960__F6 Proposed common pathways of the SRF/AR interactome and the key proteins identified by APMS and bioinformatics 6722 367 5901 27043 10383 10382 PMC11643440__F2 Insulin signaling pathway in adipocytes in healthy and obese (pathologic) subjects 2308 2309 2152 PMC11643850__F2 Signaling pathways for the neuroprotective effects of CAP and CB: CAP acts on TRPV1 and activates the PI3K/AKT/mTOR signaling pathway, enhances the phagocytosis of microglia, and activates the promoter of BDNF 7442 2475 627 PMC11643850__F3 Signaling of Wnt and calcium ions through MCOLN: CUR can activate Wnt signaling way by increasing the stability of Beta-cyclin, leading to its accumulation in the cytoplasm 324 1499 7942 4609 PMC11643850__F4 Protective Effects of Pungent Flavor Components in Neurodegenerative Diseases 4513 7494 468 PMC11645450__F3 Regulatory roles of the DUB family in signaling pathways 114609 4615 7189 958 4055 90268 56957 2885 9101 8717 828 7186 7187 7375 55432 10617 1540 7874 10454 23118 5894 27005 10600 55611 9099 9097 5970 2475 5728 2002 1386 286257 80143 7871 8237 7345 8078 23326 8975 4287 5163 220213 7398 4485 80014 55841 23286 60485 4087 4088 83844 4091 4092 9958 1499 324 26524 9113 7248 8239 10413 78990 4089 10869 55593 84669 PMC11646733__F1 Efficacy of Oroxylin A in ameliorating renal fibrosis with emphasis on Sirt1 activation and TGFB/Smad3 pathway modulation 3099 23411 4088 PMC11646805__F2 Diagram of endothelial cell mutant GAq signaling (p 5728 7248 7249 6009 2475 2776 PMC11647257__SF2 Various signaling molecules, such as glucocorticoids, androgens, progesterone, BMP4 (which activates SMAD), and IL-6 (which activates the downstream signaling molecule STAT3), regulate the transcriptional activity of S100P in cancer cells 652 6286 27101 6774 PMC11647257__SF6 CNN1 signaling pathway involved in cancer 1264 7077 22943 2475 4318 4313 1499 PMC11647263__F6 In SAE, Nogo-A plays a critical role through a series of complex signaling pathways 3661 114548 7124 PMC11647666__F11 Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms 2475 54822 1956 4919 4920 7248 7249 6009 324 1499 664 6662 8061 8840 PMC11647666__F7 Proteome analysis after Mg treatment for t = 2 days 11337 1645 3417 55626 3091 664 3420 539 22808 4698 8803 338382 4695 9167 23236 1278 1281 513 1282 4519 4725 1277 9334 4860 7389 3073 6609 3614 1719 2938 5837 1158 6888 3703 4144 427 2581 5805 686 5130 7915 7086 2729 1355 166929 283209 93100 64802 54187 56894 113675 63917 377677 51540 64324 92935 51074 29940 55650 11285 2595 5501 1376 1301 5646 1307 1289 481 1290 3672 2335 3371 6385 3339 10370 203228 PMC11648424__F2 Compound target–protein–protein interaction functional enrichment network of A 5423 3611 2580 2147 3359 1198 8445 51135 27163 5243 3932 865 1019 7046 998 5566 218 2321 29110 5604 558 2911 5595 3363 9212 4914 3702 43 7272 4397 1719 6198 766 5601 80854 6850 695 3065 10013 7442 157 156 6531 23411 673 3248 367 4750 27040 1196 6622 25797 5291 6548 6714 1845 983 7052 1812 5594 9373 8841 1588 2475 5600 1376 3066 5293 572 1432 79885 3358 51567 10038 7201 207 4311 6319 10203 2260 1387 208 3757 3577 100306940 23476 5024 27250 993 6555 8019 2170 5771 5770 994 5289 150465 142 57007 5742 2053 1230 3417 2931 5603 4193 824 5972 10000 3815 3156 1268 7015 5467 2168 5465 5468 2167 PMC11648684__F8 M6A on apoptosis 56339 79068 581 54915 4609 5728 253943 90550 10644 PMC11648684__F10 Main mechanisms involved in the regulation of oxidative stress by m6A 56339 9817 54487 847 4899 7019 79068 9377 253943 57721 9589 10935 283450 23461 51310 PMC11648684__F11 M6A is involved in regulating the immune function of innate immune cells neutrophils, macrophages, NK cells and adaptive immune cells T cells and B cells 54890 51441 126204 3371 65125 56339 79068 4853 57721 10113 920 PMC11648720__F8 Schematic diagram shows that two residues change in SARS-CoV-2 N protein trigger NFKB inhibition 4615 8717 717 7186 7188 3654 51135 7189 23118 257397 7113 8737 57506 PMC11648920__F3 Schematic diagram represents the DEGs expression enriched in SA, JA and ET signalling pathway 4881 1879 64641 PMC11648920__F5 Various signalling pathways and resistance mechanisms in wheat in response to Puccinia infection 867 7018 4881 2077 PMC11649390__F2 Wnt signaling pathways 6259 1499 3725 PMC11649616__F3 Cancer-associated fibroblasts crosstalk with extracellular matrix 4089 4087 4088 9908 5163 4485 26524 9113 4609 PMC11650353__F7 Proposed model of curcumin inhibiting PCa progression via regulation of m6A-modified circ0030568-FMR1 pathway 56339 51441 2332 PMC11650354__F1 Inhibition of the Wnt/Beta-catenin signaling pathway by WIF1 11197 22943 4316 PMC11650354__F2 Inhibition of the non-canonical Wnt signaling pathway by WIF1 7474 7481 11197 387 5879 27123 PMC11650354__F3 Inhibition of the PI3K/Akt, NFKB, and TGFB signaling pathways by WIF1 11197 2475 4313 4318 4087 PMC11650354__F4 DKK3-related signaling pathways in Wnt/Beta-catenin and non-canonical Wnt signaling 27122 1499 4609 595 8313 PMC11650354__F5 DKK3’s inhibition of the PI3K/Akt signaling pathway 27122 2475 5728 6010 367 PMC11651285__F1 First-line treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives 1956 2885 2475 PMC11651441__F11 Inflammatory signaling pathways of SYGCT therapy for asthma-IBS 920 150365 8717 8772 55540 4703 114034 29110 6955 9618 29761 257397 100187907 7189 2920 6347 3627 7124 4513 3934 6278 6280 4318 4322 324 3662 3718 3716 3717 6095 196 1610 952 2353 27040 6778 2625 3466 50943 100187761 29984 PMC11651451__F2 Oxidative stress and inflammatory response leading to CHD associated with SLE 7412 3383 7124 5806 PMC11651451__F3 Initiation and activation of inflammasome of NLRP3, and the production process of IFN-I 7124 114548 3665 3661 PMC11652206__F2 Mechanisms by which phthalates affected sex steroids-related pathways 1628 1583 1586 6770 949 3293 367 6716 1432 5602 6469 2255 652 PMC11652206__F3 Mechanisms by which phthalates affect epithelial-mesenchymal transition (EMT) 9475 6093 1628 367 999 5217 4087 4088 4089 1000 PMC11652206__F4 Mechanisms by which phthalates affected autophagy 1628 64399 2475 5727 367 2735 PMC11652206__F7 Hypothesized macro-mechanism by which phthalates induce hypospadias 6716 367 6774 7422 PMC11652361__F2 Illustration of osteoclasts differentiation 960 6850 7189 PMC11652534__F3 Annotated map of the target genes related to Beta-sitosterol in VR on RA-related signaling pathways 4088 51701 6502 4193 5728 3630 3643 664 9140 7874 472 1017 6774 10365 2290 2885 5879 6850 930 373073 951 2475 6009 7249 572 6256 PMC11652788__F5 TsRNA in neurodegenerative diseases 10978 4553 54888 PMC11653102__F8 AD-like neuropsychiatric dysfunction in a mice model induced by the combination of high-fat diet and intraperitoneal injection of streptozotocin 54210 54209 3667 7124 PMC11653397__F5 Proposed metabolic pathway of PCB95 in mice exposed to PCB95 based on the LC–HRMS analysis of intestinal content samples 8473 27294 1312 PMC11653467__F7 Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis 7494 22926 468 581 PMC11653477__F1 Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy 627 23411 9817 3479 PMC11653592__F1 Main metabolic processes of estrogen 1545 1576 1543 3294 1312 3292 PMC11653592__F2 Mechanism of 16Alpha-OHE promoting pulmonary hypertension 64321 894 1869 948 4087 4088 4089 659 4090 4086 7124 348 3397 27035 50507 5214 595 6647 8161 PMC11653592__F4 4-OHE in pulmonary hypertension; 4-OHEs competitively decrease the activity of 2-OHE2, inhibiting the formation of 2-ME2 9817 367 2950 4513 7124 2475 PMC11653592__F5 Influence factors of CYPs and HSD17B in PH 5142 1545 27035 595 196 260431 4513 7124 3481 3479 3292 406992 3294 PMC11653707__F1 MTOR signaling in activating TME cells 1956 2475 6009 3716 5163 7248 PMC11654178__F4 Upstream Pathway of Triterpenoid Synthesis in C 3156 4598 4597 2224 PMC11654217__F1 Proposed signaling pathway representing PD-1, PD-L1, and their interactions 3466 1950 7124 4582 1956 6772 89780 2475 1499 6935 PMC11654217__F4 Mechanistic overview of targeting PD-1/PD-L1 by bioactive natural compounds 6772 1956 7124 4582 952 6850 2475 6774 PMC11654217__F5 Impact of natural compounds targeting PD-1/PD-L1 on various signaling pathways 2879 5728 6714 3845 920 PMC11654293__F8 Expression levels of differentially expressed genes related to galactose, starch and sucrose metabolism 11181 2821 8972 7360 2717 3906 PMC11655208__F4 Circadian regulation of drug response in mental disorders 5468 3371 268 1644 1312 771 377677 PMC11655346__F1 Unique role of DLL3 in the notch signaling pathway 429 3516 102 10683 PMC11655665__F0 Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFKB1/CXCL9-mediated tumor growth and metastasis 1573 5339 4283 4790 PMC11655924__F1 Anomaly of the insulin-signaling pathway 5894 6654 2885 126669 3667 6009 2475 7249 7248 PMC11655924__F2 Adrenergic signaling at the crossroads of diabetes, obesity, and cancer 155 10221 156 3667 PMC11655924__F3 High glucose in diabetes enhances Wnt-stimulated nuclear accumulation of Beta-catenin 4041 4040 324 4920 6259 1499 595 51176 387 PMC11655944__F2 Antitumor effects mechanism of EH 595 4318 7099 3553 6774 7494 468 581 7124 4609 5155 4313 PMC11655944__F3 Main components of EH Antitumor’s effects mechanism 581 4087 4088 4089 1021 1017 6774 2475 5347 1956 PMC11656820__F1 Tim-3 signaling pathway 3146 2534 3932 7535 PMC11656820__F2 Expression of Tim-3 on various immune cells and the functional alteration of these cells in sepsis-induced immunosuppression 1121 7124 3146 3586 960 50943 PMC11656958__F7 Schematic diagram depicting that STING exerts antiviral innate immune response by activating pentose phosphate pathway 115004 7337 7086 29110 3661 PMC11657104__F1 Biosynthetic pathway of L-Homoserine in E 85569 7068 7067 11113 443 PMC11657277__F9 Function and mechanisms of Chiglitazar in CML cells 2475 3099 5214 PMC11657595__F2 Mechanisms of GDF15 expression, maturation and secretion 9817 468 467 9518 PMC11657697__F1 Inflammasomes are multiprotein complexes composed of several domains with distinct functions 6010 3146 6280 22861 58484 171389 9447 114548 79792 PMC11657697__F2 Inflammasomes in the three stages of HSCT Mobilization 6280 79792 3146 7412 7852 PMC11658145__F7 Schematic summary of the effects of PEVs on the MV3 and A2058 spheroids 1401 967 975 928 PMC11658190__F2 Functions of the Ddx family in the development, differentiation, and homeostasis of oligodendrocytes 11218 4193 79039 4155 1655 PMC11658190__F4 Dual inhibition mechanism of the p53 pathway by Olig2 11218 50628 8487 54960 79833 79760 25929 4193 10215 PMC11658435__F7 Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGFB/Smad2 axis in oral submucosal fibrosis 4087 4088 4089 PMC11659109__F3 Triggers for postnatal metabolic shift 3091 7351 2717 PMC11659141__F4 Complement and coagulation genes are differentially expressed in head kidney samples between A 718 730 966 1431 PMC11659389__F5 STRING protein‒protein interactions between the recognized proteins and our prioritized proteins for each skin cancer 51684 6608 51284 7062 6469 1520 434 51151 7157 6855 1029 3872 3866 3848 3861 631 7015 386676 4157 2315 4055 81037 673 4507 3550 4893 6098 823 PMC11659631__F8 Mechanism of GGO inhibited cervical cancer cell proliferation and angiogenesis 2475 10253 5728 4313 4318 PMC11660123__F2 AIM2 regulation in CRC, HCC, and RCC in inflammasome-independent manner 9447 4261 2475 3122 619501 PMC11660123__F3 AIM2 in regulating the development of breast cancer and LUAD independent of inflammasome 9447 6774 572 581 PMC11660139__F8 Inhibition of miR-675 on TGFB signaling and OC progression 4087 4088 4089 100033819 PMC11660554__F5 Alterations in the HSV-1-associated host antiviral signaling pathway in HGFs 57506 3665 811 PMC11661762__F2 Key enzymes of glucose metabolism (gluconeogenesis, green arrows), DNL (blue arrows), and FAO (orange arrows) are activated by TH (in red) 2194 95 5166 7351 PMC11661909__F4 Metastatic brain metastasis 6624 5879 10715 3135 960 5395 1956 6774 1499 23476 7403 4314 7852 10232 3725 5979 4582 3383 9732 5167 5156 PMC11662063__F6 Proposed model suggests that SS18-SSX drives the acitivation ofTYK2/STAT3/Bcl2 axisthereby mediating apoptosis evasion in SS cells 7297 6774 596 PMC11662066__SF3 Clinical pathway, Cohort II 54113 1401 90550 100187761 PMC11662157__F2 PI3K/mTOR signaling pathway during early T cell development 64223 3575 7852 3280 5728 5163 PMC11662456__F1 Figure demonstrates PPARG and its relation to signaling pathways 6955 3006 3024 PMC11662631__F8 Schematic show that the mechanism of hsa_circ_100791 promote the progression of allergic rhinitis 4076 10206 3565 90865 7124 3558 PMC11662784__F2 DEAD-Box Helicases in Esophageal Cancer: DDX5: DDX5 enhances the expression of CDK2 and Cyclin D1, promoting the G1/S phase transition in esophageal cancer cells 1655 1017 999 317781 9879 5728 1499 2475 PMC11662784__F3 DEAD-Box Helicases in Gastric Cancer: DDX5: DDX5 increases the expression of p-mTOR and p-S6K1, promoting the growth of gastric cancer 1655 1656 8886 9188 57062 55661 9879 1017 3098 2308 29102 2932 4026 898 2475 5728 PMC11662784__F4 DEAD-Box Helicases in Colorectal Cancer: DDX3: DDX3 enhances the transcription of KRAS by increasing the binding of SP1 to the KRAS promoter, leading to increased KRAS expression and activation of the PI3K/AKT pathway 1655 1662 10521 9188 55661 3845 6667 1856 1499 2475 4869 11224 11091 2305 6935 79901 983 PMC11662784__F5 DEAD-Box Helicases in Colorectal Cancer: DDX27: DDX27 promotes the gene expression of known CSC markers (CD44, CD133, EpCAM, LGR5), stabilizing the self-renewal phenotype of CRC cells and contributing to tumor initiation and development 55661 7919 54606 9879 8549 960 4072 2525 7465 10273 1021 595 4087 6935 PMC11663348__F1 Stimulation by oral pathogenic bacteria induce dysfunctional PDLFs 114548 7099 7097 24145 51295 64127 8031 10156 6774 11035 197259 PMC11663375__F3 The core regulatory pathways involved skin inflammaging (including NFKB/RIG-I, mTOR, TGFB, AMPK–SIRTs pathways) 7939 387 6885 2475 4087 4088 23411 8195 4092 4091 64750 64798 4089 23410 51547 22933 23408 51548 23409 5971 6009 4397 114548 9474 10533 5648 10747 102 718 79792 717 727 735 PMC11663674__F1 Isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities 51076 26136 4151 4199 5539 5132 PMC11663741__F7 Protein-protein interaction networks were analyzed among differentially abundant proteins 919 7535 5345 629 727 26253 2322 5880 1500 1794 3689 5908 10747 3717 5599 4773 5293 5336 7454 22800 5534 3688 55970 1230 713 714 6774 3672 409 7450 4067 974 1675 5551 256158 64170 3662 PMC11663741__F10 Hypothesized immune mechanisms of fish spleen against N 919 7535 5293 933 974 10892 5551 5336 26253 4615 5880 4773 10563 715 716 727 2512 2495 1356 2181 PMC11663867__F4 Cerebrotendinous xanthomatosis: a literature review and case study 1593 1581 80270 PMC11663879__F4 Molecular mechanism and RNA modification with their functions in Macrophage 6772 51441 79068 6778 2113 9589 PMC11663918__F1 Changes in proteins induced in the cytosol of microglia activated by BzATP and lipopolysaccharide (LPS) 4615 7128 7189 114548 1958 7124 PMC11664622__F1 Hepatitis B virus immune tolerance mechanism 1493 3661 3466 7124 PMC11664622__F2 Pathogenesis of liver cancer 5727 6608 51684 4041 4040 102 8312 324 1499 596 1026 100379198 PMC11665378__F1 Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications 5163 5728 5294 5293 5291 2475 253260 64223 PMC11665378__F3 This schematic illustrates the downstream pathways influenced by AKT activation 4193 572 331 7249 6009 2475 2932 2695 PMC11665378__F4 Schematic view of the relationship between ncRNAs and LC cell proliferation and apoptosis via the PI3K signaling pathway 100506660 404266 693185 4851 56339 100302167 51352 5728 100302122 898 581 1019 1021 728655 643911 4858 693220 PMC11665378__F5 Schematic view of the relationship between ncRNAs and the LC cell progression, invasion, and migration via the PI3K signaling pathway 100506866 5728 255480 101928607 1956 1728 647979 PMC11665378__F6 Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications 554202 1956 100996301 652995 196872 285084 100874091 7148 1000 999 3667 5728 400619 PMC11665856__F7 A working model of PFOA stimulation of lung cancer metastasis 5829 6714 5728 PMC11666154__F5 LTBP3 combined with SLC (TGFB and LAP via disulfide bonds) significantly strengthen the bioavailability of TGFB 7939 4054 4087 4088 4089 5947 PMC11666815__F1 Schematic illustration of the natural compound–induced protective effects against CVD damage through AMPK/SIRT1/PGC‐1A signaling pathway 114548 7019 4899 PMC11666973__F6 Pattern diagram of H9N2 PB1 regulation of the RIG-I signaling pathway 57506 29110 7706 3661 PMC11667047__F1 Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions 23456 54977 210 7390 10058 2235 130749 7389 PMC11667047__F2 Molecular mechanisms underlying the physiological and pharmacological effects of 5-ALA (in the presence of Fe2+)The green line indicates positive regulation, the red line indicates inhibition, the dashed line represents indirect effects 3667 613 9817 7350 7351 PMC11667055__F6 Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation 5052 7099 4772 730249 PMC11667160__F3 ERS-induced apoptosis 22926 7186 468 30001 581 PMC11667160__F4 Schematic diagram illustrating the macroautophagy process 8408 9776 60673 9140 83734 9474 10533 64422 PMC11667160__F5 Schematic diagram of ERS regulating autophagy through four pathways 22926 7494 7186 468 83667 2475 PMC11667160__F6 The common upstream signaling pathways of autophagy and apoptosis under ERS 22926 1612 468 7186 7494 30001 2475 581 PMC11667232__F6 Big data analytics for aortic aneurysm 55744 4638 7112 7078 4321 6693 5447 6497 PMC11667561__F7 Illustrates the TCA cycle, MVA Pathway and downstream of saponins synthesis metabolic pathway 3652 2147 5925 PMC11667779__F3 Adenosine signaling in TAMs 84890 8205 29 383 PMC11667780__F2 mTORis inhibit tumor metastasis to the lungs by suppressing EMT, tumor proliferation, and angiogenesis, whereas CNIs exert the opposite effect 64223 64798 4072 3091 PMC11667780__F4 mTORis reduce the number and function of Tregs via multiple mechanisms to inhibit tumor progression 7248 7249 6009 50943 PMC11667808__F5 PI3K/AKT/mTOR, JAK/STAT3 and Rho pathway in optic nerve axon regeneration 9021 6774 5728 84894 7248 7249 6010 2475 1977 PMC11667896__F2 GLP-1 (glucagon-like peptide-1) plays a vital role in neuroprotection and regeneration through multiple mechanisms 842 836 4899 581 PMC11667996__F2 Oncogenic Role of H 387 6714 2885 6722 2002 PMC11667996__F3 EBV-Driven Oncogenesis: Manipulating MAPK Signaling and Apoptotic Pathways: EBV promotes tumorigenesis through the MAPK signaling pathway, manipulating host cellular mechanisms 970 961 6667 1848 1850 2043 PMC11668132__F2 Quercetin on cancer cellular biomolecules and functions 472 581 572 5879 2475 PMC11668352__F7 Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease 468 10628 114548 22926 PMC11668677__F6 Summarizing figure for NA protective effect on lung tissues against the toxic effects of radiation 383 7124 7040 4843 4280 PMC11668798__F2 Sphingolipid rheostat targeting in adult-type diffuse gliomas 2531 204219 91012 29956 79603 10715 6609 259230 166929 81537 130367 8612 8611 8613 8879 PMC11668870__F2 TRIM14 plays a double-edged role in cancer 3661 6774 101927125 29110 2521 6941 115004 1856 4255 9830 581 2475 PMC11668870__F3 Emerging discoveries on the role of TRIM14: from diseases to immune regulation 7124 9830 114548 PMC11668870__F4 Expression of TRIM14 is upregulated in response to inflammatory stimuli, subsequently enhancing the expression of pro-inflammatory factors 9097 9830 7124 54941 79184 7099 55693 1499 5971 10133 PMC11668870__F5 Emerging discoveries on the role of TRIM14: from diseases to immune regulation 115004 100996569 9097 9830 3661 3665 6772 1283 5548 5537 57506 PMC11668900__F1 Mechanisms affecting gastric epithelial cell plasticity 54567 28514 10683 4041 4040 324 399 1499 998 5727 8643 4092 6608 4087 4088 374654 2735 2737 2736 51684 4089 22943 4609 999 7852 6935 6591 1000 100133941 PMC11668946__F1 Ferroptosis in ischemic stroke: Animal models and mechanisms 351 23657 2182 2937 10162 2879 9373 246 6520 PMC11668946__F3 AA participates in the deacylation/reacylation cycle of membrane phospholipidscPLA2A cleaves glycerophospholipid molecules at the sn-2 position to produce AA 10162 2182 4015 PMC11669278__F7 Interaction network among the key genes, enzymes, pathways, and metabolites 2806 2678 64902 2875 84706 189 95 57505 162417 3817 3816 7166 440 55191 2752 5471 790 8833 9945 2673 590 1119 1120 4129 4128 5337 314 60496 5338 1103 162466 PMC11669335__F2 Extrinsic and intrinsic apoptotic pathways 8772 581 637 317 PMC11669335__F3 Canonical and non-canonical inflammasome pathways in pyroptosis 114548 3553 79792 PMC11669335__F4 Necroptosis pathway 7124 8717 7186 8737 8772 11035 197259 PMC11669335__F5 Classical autophagy pathway 9776 60673 8408 9140 83734 10533 55054 64422 5289 PMC11669362__F6 Activation profile of the Growth hormone signaling pathway (gene expression via SRF, ELK1, STAT5B, CEBPD, STAT1, STAT3) in the experimental NSCLC groups of RECIST responders (A) and non-responders (B) to PD(L)1 ICI immunotherapy 2690 5777 3667 3717 1051 2002 6722 PMC11669362__F8 Activation profile of the Interleukin 10 signaling pathway in the experimental NSCLC groups of RECIST responders (A) and non-responders (B) to PD(L)1 ICI immunotherapy 644 7099 3586 9021 929 7538 7297 7072 PMC11669671__F3 Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products 6652 7018 145553 PMC11669671__F6 BGCs and biosynthetic pathways of (A) amphichopyrone B (39) and (B) penilactone A (41) and B (42) 273 6955 1690 PMC11669685__F6 Schematic summary of the effect and mechanism of baicalin on H2O2-induced oxidative stress, inflammation and apoptosis in BMECs 9817 1728 581 PMC11670023__F1 Triggering receptor expressed on myeloid cells signaling pathway 54210 54209 4615 6850 7535 51135 2885 3654 7189 64170 10454 8993 3146 57126 4318 114548 PMC11670207__F6 Identification of key genes related to growth of largemouth bass (Micropterus salmoides) based on comprehensive transcriptome analysis 3953 5054 2597 6774 3716 81616 1026 5468 8864 5209 666 3725 2308 5595 5970 207 5594 5880 443 5295 23411 PMC11670415__F1 Necroptosis activation in AD 7124 8737 11035 197259 PMC11670419__F1 Primary bile acid metabolism and secondary bile acid metabolism pathways with microbially encoded enzymes 1581 1593 25801 PMC11670419__F2 BA regulates glucose homeostasis 7350 2264 9965 2168 7352 1734 PMC11670419__F3 FXR signaling in diabetic nephropathy 355 26052 1499 7038 1374 PMC11670693__F1 Inhibition of the canonical Wnt/Beta-catenin signaling pathway by BI 905681 4041 4040 1499 6925 54894 84133 55366 PMC11670700__F1 Inhibition of the canonical Wnt/Beta-catenin signaling pathway by BI 905677 55366 54894 84133 4041 4040 1499 6925 PMC11670804__F5 Visualization of GO terms and DETs connected to the development of HFs in sheep 340481 6662 8861 23492 34 9415 5143 4038 1622 4047 79017 125061 4804 6120 5337 10628 4089 9475 252839 5583 4772 147409 5330 84890 301 2810 247 2033 3872 5580 3229 9612 25984 84441 2353 3883 342574 114548 6597 7053 8754 8837 PMC11670821__F1 Generation and release of exosomes in response to bacterial infection 7251 967 928 27161 PMC11670821__F5 Roles of H. pylori OMVs and infected cell exosomes in the extra-gastric diseases 1045 91662 6774 10365 3383 7412 999 PMC11670864__F1 Generation of B10 cells via in vitro stimulation of TLR pathways 54106 4615 100187907 7099 29760 640 7187 3550 3661 PMC11670864__F2 BCR and CD19 signaling pathways work together to promote production of IL-10 6714 930 2475 PMC11670978__F9 Pathway of action of HnAg in treating UC mice 7124 4583 196 PMC11671241__F7 Cortisol synthesis and secretion pathway and network of CRH‐ACTH‐cortisol signaling in Hu sheep 4158 56246 183 3949 5087 6770 PMC11671241__F5 Thyroid hormone synthesis pathway and network of TRH‐TSH‐TH signaling in Hu sheep 7054 8458 7253 7849 213 7276 7038 7173 2936 PMC11671241__F6 Thermogenesis in Hu sheep 1311 4974 26291 6009 PMC11671260__F2 Multiple drug treatments that interfere with the gut microbiota 51135 4615 5697 PMC11671467__F3 EGCG-Mediated Pathways Targeting Oxidative Stress 7124 3280 23462 PMC11671467__F5 EGCG in inhibition of cancer growth 5728 7124 581 2475 PMC11671501__F3 Apoptotic caspase-mediated pyroptosis 7124 637 581 1687 PMC11671575__F1 Signaling pathway of FOXF2 in tumor progression 7808 1956 4089 374 2295 685 3398 7018 6935 9839 9686 64207 1499 PMC11671673__F8 Schematic diagram about working model of YTHDC1 8661 91746 6256 6167 8503 PMC11672279__S1 The brain‐targeting and therapeutic mechanism of T+A@Glu‐NPs against glioma 23476 594857 4851 PMC11672291__F7 The potential mechanism by which intracellular PC capsules exert anti‐inflammatory effects by inhibiting apoptosis 5091 581 4513 85451 PMC11672511__F1 Activation of the cGAS–STING signaling pathway by cytosolic mtDNA 115004 29110 3661 PMC11672511__F4 NLRP3 inflammasome induction by mtROS 3659 7124 129607 114548 140609 PMC11672511__F5 TNFR1-mediated survival and cell death pathways 7124 355 8717 8737 197259 11035 10133 81030 29110 1540 8772 PMC11672879__F3 Protective mechanisms of phytochemicals in AMD 1728 2729 2730 23411 581 PMC11672923__F8 Signaling pathways involved in adipocyte metabolic disorders caused by melatonin decline with aging and HFD in eWAT 1051 114548 2878 4318 PMC11673094__F1 Potential molecular pathways of fatty acid, especially PA-induced vascular endothelial dysfunction, are illustrated and summarized—PA uptake by endothelial cells through fatty acid transporter or passive diffusion 50507 142 7099 55669 9927 4976 3667 114548 3491 4615 7189 3383 5806 PMC11673094__F2 Targeting to attenuate the programmed cell death is illustrated and summarized 23411 114548 100750246 5806 PMC11673094__F3 Targeting to attenuate the inflammation is illustrated and summarized 50507 7099 10628 4615 2181 114548 7189 56005 9448 5806 3553 3383 PMC11673094__F4 Targeting to attenuate the ROS is illustrated and summarized 27035 50507 23410 2740 847 PMC11673094__F5 Targeting to maintain mitochondrial function is illustrated and summarized 142 55669 23411 9927 4976 54795 PMC11673094__F7 Targeting to insulin resistance is illustrated and summarized 7099 3667 4615 7189 3383 PMC11673339__F5 Search for pathways that reflect gene expression effects of Semax and ACTH(6–9)PGP at 24 h after tMCAO in FC 2353 3717 1958 1956 7124 3164 8877 1959 162417 8974 3726 1848 PMC11673384__F1 Driver mechanisms of ferroptosis 55240 8031 2182 10162 5447 PMC11673387__F6 LTA causes mammary gland injury in dairy cows 4049 2194 22926 94005 6721 5743 7124 PMC11673418__F1 Simplified schematic representation of the PI3K/AKT/mTOR, RAS/RAF/MAPK, RB, and p53 pathways 5728 4193 4194 2475 1029 7157 1019 1021 5925 PMC11673418__F7 Wnt/Beta-Catenin Pathway 4041 4040 324 1499 PMC11673418__F9 TGFB signaling pathway in gene expression regulation 4089 4087 4088 4092 PMC11673533__F1 Artificial sweeteners affect hormonal pathways in breast cancer 3630 3479 1588 2099 PMC11673720__F2 A-to-I editing in mRNA coding region resulting in missense mutation 103 2317 387 8621 1314 2475 PMC11673720__F4 Regulatory mechanisms of A-to-I editing on Alu 103 387 6093 9475 57506 PMC11674137__F1 DOX-induced cardiotoxicity in cardiomyocytes 3146 7097 54106 2064 6774 PMC11674137__F2 Landscape of the mitophagy mechanisms 57154 79594 29110 8408 10133 65018 139341 PMC11674240__F2 TRIM proteins in the signaling pathways 7124 9830 23650 6737 7706 8717 8772 8805 10155 4087 10346 81559 11074 22954 201292 4088 10612 10626 135892 324 1499 5163 25893 4089 54765 84851 135644 91107 51592 55521 286827 PMC11674267__F1 Mechanistic pathway of methuosis-induced vacuolization 4803 5879 200576 PMC11674267__F3 Schematic summary of alkaliptosis pathway induced by JTC801, a pH-dependent form of cell death 9114 768 6774 3146 177 340061 PMC11674267__F4 How SNG induces oxeiptosis in colorectal cancer cells based on [20] 847 192111 9131 PMC11674331__F4 PAK1 and PAK2 in vascular remodeling 5879 5058 5062 572 PMC11674331__F5 PAK1 and PAK2 in angiogenesis 5879 5058 5062 PMC11674331__F6 PAK1 and PAK2 in the regulation of vascular integrity and permeability 5058 5062 998 1003 PMC11674460__F2 The molecular mechanism underlying the pleiotropic anticancer activity of As2O3 against GBM cells 581 7494 7508 4851 545 472 995 1869 PMC11674460__F6 The molecular mechanism underlying the pleiotropic anticancer activity of tetrandrine against GBM cells and GSCs 581 637 1956 999 331 5111 595 PMC11674514__F1 IL6 classical and trans-signaling activation pathways 3569 6868 102 PMC11674514__F3 Various IL6 pathway inhibitions 3569 3570 8651 9021 PMC11674646__F1 Interactions and connections between the gut microbiota, metabolites, and cellular components with IBS 8213 196 4513 650 PMC11674667__F3 HIF signaling pathway in normoxic and hypoxic state 2475 7428 2056 4313 PMC11674716__F7 KEGG network diagram of the adipocytokine signaling pathway 2475 8717 7186 9021 3952 3953 6774 5443 181 4852 PMC11674716__F11 WikiPathway outline of burn-wound healing 58 7040 1277 5175 2056 1839 58510 7157 595 2697 7422 4846 7124 4843 2335 284217 PMC11674716__F12 KEGG network diagram of the PPAR signaling pathway 335 5360 4023 1376 4312 3611 5163 7316 PMC11674716__F13 Diagram of red KEGG of AMPK signaling pathway 9370 2147 3172 29904 25886 1080 1149 355 948 7249 3630 3643 5163 5164 6009 2475 PMC11674716__F14 Diagram of red KEGG of Non-alcoholic fatty liver disease 9021 100187761 619501 PMC11674819__F2 PD-1/PD-L1 signaling pathway 324 942 940 941 PMC11674862__F2 Interactions of ADAM17 with IL-6, IL-1B, and IL-15 6868 3553 3601 PMC11674862__F4 ADAM17 activation triggers AREG-dependent pathways 374 6868 1956 6772 PMC11675326__F17 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation 2885 5901 2002 6722 2316 3727 7124 1537 8717 7186 4615 355 1616 4149 4208 929 7189 51701 PMC11675326__F18 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation 1977 7248 6009 2475 7249 1975 2885 3667 5879 6850 613 930 951 5934 5728 572 4703 4193 PMC11675326__F19 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation 100187761 64127 90550 8772 351 2271 PMC11675326__F20 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation 6009 5728 5478 472 545 90550 59341 4151 PMC11675326__F21 Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation 1398 10818 2885 627 126669 2549 572 51527 29984 7189 581 998 5879 PMC11675435__F2 KEAP1–Nrf2-ARE pathway in constitutive condition and under oxidative stimuli 9817 8452 9978 PMC11675435__F3 Nrf2 signaling pathway in RCC 7428 5546 3091 1029 29072 7030 9817 PMC11675822__F2 NPFF and its receptors’ signaling pathways 8620 64106 10886 PMC11676223__F1 Irisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology 468 2475 7351 114548 PMC11676223__F3 Figure depicts the capacity of irisin to affect multiple pathways involved in age-associated neurodegeneration and mechanisms underlying AD pathogenesis 3717 6778 4803 252995 3479 627 23411 PMC11676253__F1 Anti-Müllerian Hormone (AMH), signaling pathway in granulosa cells 268 367 2492 269 PMC11676689__F4 FoxO signaling KEGG pathway; (B) ABC transporters KEGG pathway 4089 4088 51701 6502 4193 664 9140 5728 23411 3630 472 10400 1017 6774 10365 100187907 367 7054 26154 100272147 5244 23237 23456 2717 25913 4151 7939 7018 4199 225 PMC11676821__F3 Action of PAK2 in the regulation of different signaling pathways in different cancers 51755 2475 5062 6657 55014 2182 4176 6667 PMC11676931__F5 Nerelimomab alleviates capsaicin-induced acute lung injury by inhibiting the TNF signaling pathway and apoptosis in vivo and in vitro; (some of the material is from Figdraw https://www 7124 100187761 581 PMC11677171__F1 Effects of MSC-derived immunomodulatory and growth factors on survival, migration, phenotype and function of immune cells and parenchymal cells in inflamed and injured lacrimal and salivary glands 3082 9242 50943 572 PMC11677171__F2 Molecular mechanisms responsible for the suppression of T:B cell cross-talk in inflamed glandular tissues 6774 3717 9242 355 50943 PMC11677181__F1 Wnt signaling pathways and the targets of their inhibitors 23002 387 9475 3725 64840 8658 324 1499 PMC11677427__F4 Under physiological conditions, insulin binding to its receptor (IR), which is auto phosphorylated at Tyr residues and consequently promotes the phosphorylation of its substrate, insulin receptor substrate 1 (IRS1), activates the signaling pathway 8826 8660 3667 3482 3479 PMC11677460__F10 Hypothetical model 7157 23657 9242 PMC11677578__F10 Autophagy–animal pathway 3630 5728 7249 2475 58476 1509 1514 1508 4149 PMC11677578__F11 Arachidonic acid metabolism pathway 5091 10728 27306 1733 9536 873 874 4149 PMC11677934__F8 Essential Role of Cortactin in Myogenic Differentiation: Regulating Actin Dynamics and Myocardin-Related Transcription Factor A-Serum Response Factor (MRTFA-SRF) Signaling 2017 10413 6722 PMC11678013__F2 “Disease-Pathway-Target-Component-Drug” network 6868 11040 6850 65220 6752 3958 5771 3265 590 6095 9212 1129 2324 771 1717 695 5580 7010 238 5595 5243 8435 100 6713 6790 7458 6754 6197 3965 7498 2246 6885 5604 8317 3725 768 2247 5241 5724 1610 2859 136 5465 6753 1557 5550 993 415116 7428 5294 6714 4889 6097 2908 5467 766 23632 4322 5579 390245 5802 4323 558 10135 52 135 7276 7015 4137 1269 6462 4306 5423 3643 5581 43 1909 4843 6403 3292 246 4255 1021 25 2322 3932 249 7153 4316 4293 367 3620 3099 10855 6531 1969 2203 3551 5583 4067 239 4638 2159 8824 4915 2742 10988 9429 59340 3791 2539 890 5732 4893 4321 80351 142 1511 823 7124 4314 152 8658 952 114548 5320 2932 3156 3738 4318 1080 1586 7941 116085 11255 191 5321 56923 10724 64078 2030 8851 1508 7421 1956 3312 5743 196 2147 2064 1020 2342 2222 983 5777 5747 4313 217 2101 2149 259290 6721 762 2936 1326 2167 2100 140 2152 3815 1017 6319 5783 5347 10733 150 2870 1019 5209 5159 132 673 3963 6532 2170 6865 6622 6530 1588 9133 2260 4311 351 5739 5788 5468 9536 377677 2050 3558 5578 50507 3291 5582 3294 5792 9153 3293 2171 5591 2166 2168 PMC11678534__F2 Creatine in the promotion of cancer malignancy 6535 581 3725 2593 3099 1152 4087 4088 PMC11678862__F1 Molecular mechanisms linking dietary restriction to lipid metabolism and health benefits 3479 5728 7249 7248 6009 1581 PMC11678862__F2 Dietary restriction on lipid profile changes and healthspan 3479 5465 2308 PMC11680093__F5 Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture 652 4086 4090 4092 4089 4087 4088 5225 PMC11680093__F6 Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture 5728 595 2932 572 5163 7248 7249 2475 253260 PMC11681754__F7 Potential mechanism of LPL-RH in salvaging bone calcium loss in OVX rats 4772 7189 100187907 7099 4615 PMC11682641__F2 BCR signalling and associated pathways network, genetic resistance mechanisms and pathway adaptive resistance mechanisms to targeted therapies in CLL 4919 7474 930 695 29760 973 4615 4067 3654 51135 6850 8915 10892 4609 PMC11682641__F3 Detailed overview of chronic lymphocytic leukaemia's genetic landscape in the context of signalling network 4851 958 7186 329 695 4067 7187 29760 6850 330 4615 3654 51135 581 8915 10892 596 4170 23451 8880 100653382 8847 472 PMC11682973__F1 The PI3K/AKT/mTOR signaling pathway 8408 7248 7249 3667 6009 5728 5163 9776 60673 2152 1999 2308 2309 PMC11682995__F4 Selected signaling pathways regulated by AKR1B10 5163 57016 999 3845 PMC11682996__F1 Mechanisms of IFI44L in human diseases 3455 11035 29110 3454 54210 51284 581 PMC11683013__F2 CGAS-STING pathway activation, Chinese medicine inhibits or activates cGAS-STING signaling pathway to treat various diseases 29110 115004 3661 3569 PMC11683146__F6 Tyr-Pro-induced Aß signaling pathway in SAMP8 mice 351 23621 3416 PMC11684189__F1 Cholesterol metabolic pathway 29881 4023 64240 64241 8647 3949 19 1581 3156 7038 PMC11685086__F1 FSH functions through the FSHR 2492 7412 7350 3949 3156 PMC11685086__F2 Action of FSH-FSHR in OC proliferation and EMT 2492 5728 8877 56848 999 1000 595 PMC11685086__F3 Nanotechnology and immunotherapy for ovarian cancer (OC) targeting FSHR 2488 925 652070 3099 940 PMC11685696__F4 Intestinal microbiota mediate CID through the TLR receptor and cGAS-STING pathway 7099 4615 4049 51135 7189 51284 54106 51311 7098 29110 3665 3661 7124 3569 115004 PMC11686125__F5 Related target action relationship between QJ and the HIF-1 signaling pathway 7099 6774 7428 9978 8453 2056 7018 7012 2475 5163 5211 226 2597 2023 3939 PMC11687105__F1 M(6)A biological functions 2305 51426 3815 6657 79923 255743 402381 1982 26986 595 89845 51441 9474 10533 54915 79068 627 25962 1154 8651 9021 2475 8835 79365 3579 2919 2194 8823 PMC11687105__F2 Therapeutic potential of RNA m(6)A in lung cancer 54822 23604 207 23657 3198 2146 5881 6423 2475 3726 5728 65018 167227 5352 56339 57721 9470 1613 3014 80144 23476 79066 1300 25962 9589 5820 8835 2305 54890 7078 11065 7083 10642 10643 7291 3183 9787 10644 990 7874 7593 1869 64848 4753 54915 79068 2324 51441 2539 9140 3181 8312 3399 9817 7145 1540 81610 1645 PMC11687129__F8 Mechanism of TAL in PD models 7200 7201 7054 1813 5914 PMC11687167__F4 Signaling pathways associated with PCSK9 during the immune response (created in https://BioRender 4772 255738 581 7099 6775 6774 6772 7054 PMC11688061__F7 Jak-STAT signaling pathway and related target expression, such as STAT 8027 3716 3717 7297 10379 7099 2475 4703 2670 9978 7428 8453 1610 7018 7037 5163 5211 226 2597 3939 PMC11688120__F3 Key signaling pathways in the pathogenesis of CCM 7099 929 57493 1003 387 57154 5290 83605 4215 10365 9314 2475 PMC11688252__F2 Key signaling events underlying D-lactate-induced metabolic reprogramming in bFLS 3939 3091 5163 PMC11688305__F1 The structural comparison and similarities between CD4 and LAG-3 920 3902 6868 102 324 PMC11688383__F1 ER stress and activation of the UPR signaling pathways 7494 22926 468 PMC11688383__F2 Insults to airway epithelial cells, their impact on UPR and the consequences of UPR activation 22926 7494 468 PMC11688383__F3 Inflammatory signaling pathway regulated by UPR 22926 7186 468 22809 10628 PMC11688383__F5 ER stress-mediated autophagy and the possible mechanisms 7186 8408 9776 60673 7405 9140 9474 22926 468 1612 PMC11688492__F3 The molecular mechanisms related to microglia activation by the SARS-CoV-2 and S protein 7099 4615 114548 3606 3553 24145 6868 PMC11688492__F4 The molecular mechanisms related to astrocytes activation by the SARS-CoV-2 and S protein 8829 4318 1803 PMC11689543__F5 Inflammatory and immunoregulatory role of megakaryocytes in sepsis 7852 3569 90865 920 7054 85480 1236 7097 7099 3458 10410 3383 388 6010 114548 5132 79792 115004 3146 100170220 6813 PMC11693507__F2 IL-6 signaling pathway in kidney cells 9021 6774 1003 6374 407040 558 1786 PMC11693700__F3 BAP1 and USP37 in the HIF signaling pathway 29923 2012 50507 PMC11693700__F4 VHL and Beta-TrCP in the Ferroptosis signaling pathway 7428 8314 57695 PMC11693700__F5 BAP1 in the Ferroptosis signaling pathway 23657 7428 8314 2937 2879 PMC11693700__F6 Deubiquitylase in the PI3K/AKT/mTOR signaling pathway signaling pathway 5728 220213 84937 7428 64854 54585 55294 8140 PMC11693700__F7 Deubiquitylase in the p53 signaling pathway signaling pathway 2475 9100 10616 4193 91107 PMC11693700__F8 Key proteins in the HIF, ferroptosis, PI3K/AKT/mTOR, and p53 signaling pathways are subjected to ubiquitination modifications by deubiquitinases and E3 ubiquitin ligases 2475 7428 55294 91107 10616 8314 57695 220213 64854 9100 2879 50507 PMC11693731__F7 Diagram of catalpol enhance Shh signaling pathway to promote neurogenesis and synaptogenesis by regulating mitochondria 847 6469 6608 2735 PMC11693940__F8 CXCR2 activated JAK3/STAT3 signaling pathway exacerbating hepatotoxicity associated with tacrolimus 6774 3718 3579 2920 999 PMC11694028__F3 Interaction of FBXW7 with signaling pathways and key molecules in gastrointestinal cancers 1950 1956 1499 324 8036 55294 4851 302 5728 581 983 1017 4134 2475 27035 PMC11694080__F7 Fluxes of glycolysis, pentose phosphate, and TCA cycle pathways in hMφ treated with DETA‐NO and CK 6120 5183 259266 133 5091 2731 6101 PMC11694134__F4 RAS pathway activation and downstream effects in chronic myelomonocytic leukemia 5781 6654 6655 2885 4763 867 5163 7248 7249 6009 1019 1021 595 6790 5347 7465 983 995 PMC11694134__F5 Additional established and investigational therapeutic targets in chronic myelomonocytic leukemia 3553 114548 596 3205 23476 11006 5132 54790 PMC11694147__F7 Mechanism of protective effect of Herpetospermum pedunculosum seeds on liver 9817 7939 4087 4088 4089 PMC11695279__F4 M6A-mediated tumor regulation in the immune microenvironment 56339 958 941 7099 10644 11278 57721 54915 200734 3579 54890 9123 6774 10643 79068 3726 PMC11695430__F1 Protein signaling pathway involving both DAMPs and selected cytokines in ICD modulation 3146 811 3308 3320 3576 3627 3569 3456 7124 3605 3458 3592 3593 51561 PMC11695688__F9 Simple signaling pathway diagram 2335 64393 3688 PMC11696735__F5 Biosynthetic pathway of steroidal saponins in P 2222 7108 1718 1717 10682 PMC11697715__F3 Histone lactylation changes in tumor-associated macrophages 7189 8205 383 PMC11697870__F5 Multifaceted biological processes and pathways that are identified to be associated with AD progression 5243 51206 613 PMC11697911__F7 Graphical overview of the canonical role and potential regulatory mechanisms of the Notch signaling pathway on porcine oocyte maturation 54626 3280 23493 23462 3714 28514 182 10683 54567 PMC11699683__F2 UA in antioxidative stress and anti-inflammation 56606 7097 7099 114548 PMC11699683__F5 Signaling pathways of UA-mediated antioxidative stress and anti-neuroinflammation in neurodegenerative diseases 627 4041 4803 9817 6774 8312 1499 324 PMC11700300__F2 Pathogenetic mechanisms of WT1 in AML 596 7490 8900 595 4609 54790 55384 PMC11700734__F11 Metabolomic and metagenomic analyses elucidate the role of intercropping in mitigating continuous cropping challenges in tobacco 7054 7275 3240 81553 20 100653365 23237 7939 9429 133418 5212 26509 5091 PMC11700868__F1 Scheme of establishment and application of Nano-IFNG/Zole for remodeling the suppressive TIME induced by iRFA 3458 383 4843 6778 3662 6772 3459 3460 3716 3717 3652 7942 PMC11700987__F1 NRF2/KEAP1 signaling pathway adapted from [17] 9978 8452 9817 2730 1728 PMC11700987__F2 Staphylococcus aureus prevents Nrf2 pathway activation in THP-1 macrophages through upregulation of MAPK/p38 and downregulation of p62/SQTM1, scheme modified from [35] 9817 7124 6347 6648 PMC11700987__F3 Activation of Nrf2 in S 2810 9817 7124 4094 PMC11700987__F4 Listeria monocytogenes evades the host immune response by Tim-3-dependent inhibition of the Keap1/Nrf2 signaling pathway 8452 9817 948 PMC11700987__F6 Keap1/Nrf2 signaling pathway plays a crucial role in the cellular response to P 7039 1839 1956 9817 3151 847 PMC11701040__F2 Mechanisms by which mitochondrial dysfunction drives the development of chemotolerance in colorectal cancer (CRC): mitochondrial dysfunction drives CRC cell proliferation and chemotolerance 673 375 983 139562 113115 1499 PMC11701242__F10 MTORC1 pathway by condensate 2475 7249 8444 10146 64798 64223 PMC11701242__F3 Mechanism and activation of the Hippo pathway through phase separation 154796 4485 7871 26524 9113 PMC11701242__F4 Pathogenesis and therapeutic resistance mediated by the phase separation of the Hippo pathway 10046 23476 5469 4841 9113 735301 26524 4485 780 4771 3661 29110 57506 2033 PMC11701242__F5 Molecular mechanisms of phase separation in cGAS-STING-mediated innate immune responses 115004 10146 79699 5094 11277 3661 29110 3665 23411 PMC11701242__F6 Molecular mechanisms of phase separation in TGFB, NFKB, and JAK-STAT pathway 7124 4087 4088 4089 6421 1499 6774 PMC11701242__F7 Phase separation-mediated MAPK/ERK activation of T cell signaling pathways 324 3932 7535 5335 27040 2885 1443 PMC11701242__F9 Phase separation in Notch signaling for oncogenic Myc activation and developmental fate control 3516 23476 5469 317762 8650 PMC11701794__F3 CEMIP‐related hyaluronan (HA) degradation occurs through rapid vesicle endocytosis 57214 960 1956 8692 3036 3037 3038 PMC11701794__F2 CEMIP affects the PI3K/AKT, EGFR, and Wnt/B‐catenin signaling pathways, which contribute to cancer progression by promoting cancer cell growth, angiogenesis, and proliferation, while also inhibiting cell death 3710 57214 23657 10371 1956 430 5467 PMC11702054__F2 TRIB2 in the physiological proliferation of granulosa cells, myoblasts, naive T cells, and thymocytes, and pathological proliferation of VSMCs 28951 2475 864 920 1958 PMC11702054__F3 TRIB2 in the lung cancer cell, liver cancer cell, and leukemia cell proliferation 28951 6737 4088 3939 64326 581 595 6774 8091 1869 1499 57154 5094 5693 10682 7037 2879 5090 4211 3205 6925 PMC11702054__F5 TRIB2 in melanoma cell, colorectal cancer cell, ovarian cancer cell, and osteosarcoma cell proliferation 1499 28951 55000 PMC11702196__F7 Lipid Metabolism Regulatory Network Revealed by Multi-Omics Data Analysis 10010 4312 3308 958 5330 929 8743 3929 54205 7097 19 2920 355 1147 317 7157 4047 3717 3845 3265 1385 1594 6307 7124 2673 6720 10724 5781 5728 5584 1398 3099 399694 391 PMC11702196__F8 Pearson Correlation Network of Lipid Metabolism-Related Molecules in Bovine Hepatic Cells Following TMAO Treatment 1386 7054 8205 PMC11702355__F2 Classical and non-classical Wnt signaling pathways 7481 7471 7474 324 1499 595 4609 4316 PMC11703377__F1 Remodeled fatty acid metabolism in tumor cells 95 367 1956 47 2475 2194 7428 6319 PMC11703395__F5 Advanced whole transcriptome sequencing and artificial intelligence/machine learning (AI/ML) in imiquimod-induced psoriasis-like inflammation of human keratinocytes 2520 887 5777 5781 2776 1154 5894 5604 4133 5770 2475 1026 3725 3569 2353 598 920 5698 5696 5693 5694 3458 2923 6892 4261 PMC11703747__F2 Cellular metabolic pathway involving GOT1 3091 3845 2805 23411 50943 PMC11703838__F2 Signaling pathways in TCSCs 23028 324 1499 6608 374654 51684 6774 2737 2735 2736 9794 6657 79923 PMC11703838__F5 Crosstalk between TCSCs and immune cells 8205 140885 6347 6359 1435 7097 7471 89780 3569 284266 961 6774 PMC11703843__F1 LLPS and signalling pathways in the cytoplasm of healthy liver cells and HCC cells 122786 51135 3654 3656 7189 257397 619501 PMC11703929__F1 Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis 29110 115004 3661 PMC11704404__F1 Schematic diagram illustrating the role of hepatic AMPK in regulating lipogenesis and lipolysis 2475 23411 84680 2194 PMC11704404__F2 Autophagy initiation regulated by AMPK and mTORC1 7248 7249 6009 8408 64223 9776 8678 2475 64798 60673 9706 22863 PMC11704410__F7 The function of Tanshinone in androgenetic alopecia 222545 50506 53905 405753 90527 PMC11704687__F6 Signaling pathway model 26524 9113 9201 374 332 PMC11704872__F3 Inhibition of autophagy by the IGF-1 signaling pathway 5163 3479 3481 3480 8660 3667 64798 7248 7249 572 6009 9706 8408 PMC11704872__F4 The IGF-1 Signaling Pathway in Mitophagy 3479 664 4899 PMC11705062__F4 Impact of lysine succinylation on signal transduction 2200 4851 6281 PMC11705629__F5 AMPK signaling pathway in macrophages and fibroblasts cross-talk 4092 64750 4089 4087 4088 1435 6347 2475 7249 PMC11705844__F7 The mechanism by which BMAL1 deficiency impairs cognitive function 374 351 23621 1956 406 PMC11706183__F8 Uncovering iron imbalance and inositol metabolism disruption: insights from the yeast model of N88S seipinopathy 5300 5091 3630 PMC11706781__F1 Angiogenic cascade and metabolic reprogramming of ECs in tumorigenesis 4851 5209 2194 26227 29968 1374 355 440 PMC11706781__F3 Interactions between immune cells and tumor endothelial cells in the tumor microenvironment 7422 5209 1374 440 7006 100124696 2194 8205 PMC11706994__F8 LCWE-induced ALI 7097 7099 4615 3569 114548 PMC11707140__F5 Dysregulated expression of genes associated with neurovascular coupling 2911 5338 5743 80228 59341 3759 387 5742 4137 PMC11707400__F5 Immune signaling pathway of infected cells 7113 115004 59272 7097 10333 7096 7099 3466 4615 54106 51284 51311 7189 7187 3665 3661 PMC11707604__F1 Severe asthma immunopathogenesis in type 2 (T2)-high asthma and the specific targets of biologic therapies 85480 64806 90865 PMC11707604__F3 Signal transduction via interleukin (IL)-4R complexes and mechanism of action of dupilumab 3717 3718 3716 7297 6778 PMC11708511__F7 Inhibition of triple-negative breast cancer growth via delphinidin-mediated suppression of the JAK2/STAT3/PD-L1 pathway 3717 6774 969 PMC11711130__F6 SPC enhances Th9 cell differentiation and function by upregulating Smad3, STAT5, and Beta-catenin signaling pathways, mediated by increased mitochondrial ROS 4088 4087 3902 1493 PMC11711403__F9 Model depicting PBLD and Cedrelone inhibit viral replication via activating the NFKB-mediated IFN-I signaling response 64081 6737 10379 PMC11711721__F7 Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/Beta-catenin pathway modulation 324 2932 1499 PMC11711753__F4 Analysis of a phosphoproteomic perturbation dataset in PTMNavigator 2475 1956 2885 3667 673 57521 7249 6009 1977 51256 5163 253260 6194 2932 3925 4609 PMC11711753__F6 Extending a canonical pathway with PTMNavigator 4342 6654 5894 673 5604 5605 5595 5594 5597 5596 387 6093 9475 9459 8874 2549 6195 2077 6548 4904 2932 2017 6449 983 6655 8021 23152 PMC11714729__F3 Hedgehog signaling pathway 6469 6608 51684 2735 PMC11715079__F1 Cytoplasmic recognition of HAdV DNA occurs through cGAS sensing 5132 54106 115004 29110 3661 4615 PMC11715079__F2 Complement activation pathways and antibody neutralization effects of HAdV infection 721 717 720 718 6737 PMC11715079__F3 T-cells mediated adaptive immune responses 3458 324 5093 920 861 5094 PMC11715087__F9 Working model summarizing key conclusions from this study 55739 26227 9001 PMC11717529__F7 Mechanism of action of hsa_circ_0109623 and hsa-miR-146b-3p and their downstream target gene SORT1 in the pathogenesis of AIH 920 6272 6772 6775 PMC11718791__F1 PI3K pathway and FDA-approved, or fast-track designation-granted PI3K inhibitors 5728 5163 207 7248 7249 PMC11718791__F2 PI3K, cell cycle, and ER pathways crosstalk in HR+ HER- BC 207 7248 5163 5728 1019 1021 595 PMC11718844__F2 Signaling by IL-23R 6775 149233 7297 3717 6446 5902 2308 6774 6304 50943 PMC11718844__F5 Key approved pharmacological agents for the IL-23R pathway 149233 7297 3717 PMC11718879__F1 Hedgehog signaling pathway 5727 2735 6608 6469 PMC11719737__F4 Molecular mechanisms of UBE2T in tumorigenesis 1499 29089 55120 2475 324 2177 55215 PMC11719987__F6 Role of Notch signaling in modulating ferroptosis and its contribution to cataract formation 2495 2879 23657 182 PMC11720051__F2 Diagram of Hippo Signaling Pathway “on” & “off” states 4771 60485 4485 26524 9113 4520 81532 PMC11720236__F1 Pathogenesis of fibrosis: After tissue injury, immune cells (mainly macrophages) are activated and release cytokines (e 1499 4087 4088 4089 PMC11720236__F2 Mechanisms of exercise modulation of pulmonary fibrosis 7099 4040 1499 6374 3579 4087 4088 PMC11720236__F3 Exercise modulation of renal fibrosis 50507 23411 5465 4088 PMC11720236__F4 Exercise modulation of myocardial fibrosis 26291 2353 23411 1116 3084 11167 4087 4088 23410 407040 6774 8074 4017 PMC11720236__F5 Antifibrotic mechanisms of exercise: Exercise exerts its anti-fibrotic effects by directly or indirectly (secreting exerkines or targeting microRNAs) affecting multiple signaling pathways associated with fibrogenesis 26291 11167 1116 23411 4040 5465 1499 PMC11720488__F1 Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets 1956 64129 3215 5754 PMC11720488__F2 Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets 5728 2475 64798 253260 55615 PMC11721126__F1 The development of SARS-CoV-2 induced osteoarthritis 4312 4322 1906 1909 1910 8600 7124 PMC11721226__F2 TGFB/SMAD4 signaling pathway in immune cell; A The TGFB/SMAD4 signaling pathway promote the differentiation of naive CD4+ T cells into Th17 cells and regulatory T cells (Tregs) 920 4087 4088 PMC11721291__F7 CGAS/STING activity 3661 115004 11277 PMC11721695__S1 hCeO2@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway 1508 860 114548 PMC11722366__F2 Key signaling pathways involved in kidney fibrosis 7124 7049 10716 3717 4092 4089 6774 3716 7297 4087 3611 PMC11722372__F2 The putative biosynthetic pathway of DAs in Aconitum plants 9961 4598 4597 3652 PMC11722408__F2 Mesenchymal Phenotypes Utilize Autocrine and Paracrine Signaling to Reinforce SCLC Subtypes 375790 4179 999 1464 1950 375704 2335 3815 3897 3977 4359 100506658 3725 100187761 182 5764 5797 8531 7163 6667 3280 7054 6696 558 10400 PMC11722561__F1 Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease 1401 5212 7018 7124 3569 PMC11724356__F2 NSCLC immunotherapy resistance 567 3902 1956 3845 6794 673 3383 6774 2475 1029 4507 PMC11724432__F4 Mitochondrial Apoptosis and Inflammation 115004 331 317 3661 114548 PMC11724471__F1 KRAS proteins and metabolic pathways affected by oncogenic KRAS mutation 3845 948 3098 3099 47 3418 2194 9415 3992 2806 2475 2805 PMC11724515__F1 Mechanism of Sirtuins in the occurrence and development of obesity 51547 51094 952 7038 2308 51548 23410 23411 6774 PMC11724515__F2 Specific mechanism by which Sirtuins regulate the occurrence of osteoporosis 6648 23410 51547 1499 860 50964 22933 4772 170302 367 23411 PMC11724515__F3 Mechanisms by which the FTO and TBX15 genes regulate obesity and osteoporosis 51548 3303 79068 860 6913 9242 PMC11724515__F5 Oestrogen, melatonin and NPY on obesity and bone 3953 23410 50964 23411 51548 355 4852 860 1499 114548 3726 7003 PMC11724515__F6 SIRT1 regulates the balance between lipogenic and osteogenic differentiation of mesenchymal stem cells 51094 23411 60674 860 PMC11724797__F17 KEGG NF-kappa B signaling pathway—Homo sapiens (human) 27040 472 29760 6850 613 4067 4615 7189 8717 1540 10913 7706 4513 331 3929 929 114609 7099 4803 1950 1270 4049 4050 PMC11725633__F1 Fatty acid metabolism in T cells 948 2864 2867 338557 2865 2194 4018 PMC11725633__F2 Immunoregulation of CD4+ and CD8+ T cells by fatty acids 2625 5833 922 47 2194 50943 8320 3002 PMC11725820__F1 Canonical type I IFN signaling pathway 3455 3454 3716 7297 6772 6773 10379 56832 PMC11726638__F9 Diagram encapsulates our hypothesis that cytidine/uridine monophosphate kinase 2 (CMPK2) promotes the progression of allergic rhinitis by activating the NLRP3 inflammasome via the mitochondrial DNA (mtDNA)‐STING signalling pathway 129607 114548 115004 PMC11726887__F10 Effect of echinacoside in HepG2 cells 23657 6520 2182 2879 PMC11726942__S1 Amantadine and its therapeutic role in spinal cord injury 3075 1436 1524 9450 3074 3553 975 6696 PMC11726948__F8 Summary diagram of AGH treatment in mdx mice 1756 2308 4656 PMC11727080__F1 Fate of glucose and fatty acids in macrophages and HCC cells 619501 3099 2936 47 355 1376 23152 1431 PMC11727080__F2 Crossroad in amino acid metabolism in macrophages and HCC cells 6542 619501 435 3099 4998 4999 4942 2638 383 PMC11727142__F9 Osteoblast‐Derived ECM1 Promotes Anti‐Androgen Resistance in Bone Metastatic Prostate Cancer 1893 2023 2885 6654 PMC11727316__F6 Molecular basis of Jusvinza’s mechanism of action on neutrophils 8764 3146 7099 114609 4615 9209 7186 7188 51135 3654 7189 3059 23118 5728 11140 5971 834 92140 114548 1622 85441 6615 10226 4904 3297 2919 4312 2313 4319 6352 79143 PMC11727388__F4 Aberrant tumorigenic ECM modulates several intracellular signaling pathways involved in tumor development and progression 960 9780 154796 4089 4771 5163 1072 2475 4087 6714 6010 4485 60485 2932 324 PMC11727420__F2 Signaling interactions between the Wnt/Frizzled pathway, MINK1, Prickle1, and their downstream effects on cellular processes 144165 50488 23122 90102 PMC11727420__F4 MINK1 and JNK signaling pathway interaction 104472715 50488 9448 23043 PMC11727420__F5 MINK1 and Hippo pathway regulation 50488 9113 26524 PMC11727972__F6 Bile acids (BAs) regulate cancers via the farnesoid X receptor (FXR) 860 4316 1956 2475 3717 6774 9021 6714 4585 PMC11728246__F2 TRAPPC4 and TRAPPC9 in cell signaling 83696 5971 51399 PMC11728517__F4 Extrinsic and intrinsic apoptosis pathway 8772 8717 7186 637 581 331 PMC11729014__F13 Mechanism of action of NCOA4-mediated ferritinophagy-induced ferroptosis promoting endothelial injure 4280 348 7412 115004 8031 PMC11730190__F4 Action of DPEP1 in malignant tumors 1956 2821 430 1800 999 4609 2475 PMC11730944__F5 Upregulated and downregulated gene expression profiles within distinct pathways 6366 10563 7852 4050 3623 114609 6846 3976 2057 6761 4838 3953 268 PMC11731108__F2 T cell senescence‐related signaling pathways 472 10454 3932 7535 115004 7124 7015 6772 6774 PMC11731210__F10 Work model 1869 4605 2638 144455 PMC11731478__F1 Metabolic pathways of riboflavin in E 5640 22934 1896 PMC11731763__F9 Signaling pathway of LH resist apoptosis and promote proliferation of freeze-thaw folliculars and granulosa cells by TGFB and its superfamily members 2661 9210 668 8549 PMC11731776__F2 Figure compares normal and G3BP1-depleted or inhibited senescent cells 10146 3661 6774 PMC11731776__F3 Figure illustrates the DNA damage response pathway leading to cellular senescence 2626 472 545 595 1019 1021 1017 PMC11732762__F2 CD28 signaling in FOXP3 expression and the effects of belatacept 324 941 942 940 5970 2475 50943 PMC11733248__F2 Current therapeutic targets in gastric cancer and GEJ adenocarcinoma 22943 5163 2475 PMC11734361__F4 Tumor-associated-mycobiome regulates the physiological and immune responses of cancer through different signaling pathways 6850 5879 64170 64127 5923 3265 2695 5236 3099 3716 3717 2997 8915 10892 6772 PMC11734646__F9 SCF involves in the regulation of immune response 26273 54620 23291 23014 326 5310 PMC11735026__SF4_3. GnRH signaling pathway: The KEGG graph shows the involvement of ADCY3 and MMP2 genes driving the GnRH signaling pathway 2798 4323 4313 1839 1956 2778 109 5566 468 3708 801 815 2767 5330 4214 5606 1432 5598 3972 5337 6714 998 5599 3725 2185 2885 6654 3265 5894 2002 1958 1081 2488 PMC11737358__F2 Metabolic pathway of homoarginine (hArg) synthesis and associated substrates 5009 2628 383 353189 435 445 PMC11739089__F6 Research progress on the synthesis process, detection method, pharmacological effects and application of glycocholic acid 4015 4512 4049 4050 5226 PMC11739150__F1 Structures of the insulin/insulin-like growth factor (IGF) system 126669 2885 3481 3479 7249 572 PMC11739504__F7 Summary illustration of this study 8850 6295 7054 6608 PMC11740111__F5 Analysis of the effects of TPBG-KD on signaling pathways using KEGG 54894 147111 25776 51701 324 50964 25805 27130 4163 6477 9978 6259 126669 213 1794 PMC11740368__F5 Pers expression regulates tumorigenesis 8864 9575 7465 891 648 2475 8863 1499 4193 PMC11740368__F6 Cancer stem cell generation and mechanisms of PERs action on cancer stem cells 920 406 8863 8864 1499 9575 PMC11740643__F5 Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis 3630 4089 6418 5728 1956 3458 1537 351 1017 51274 1513 100187907 PMC11740669__F1 Autophagy negatively regulates pyroptosis pathway 5899 114548 345611 26191 3965 64844 8408 2475 79792 5728 11274 142678 PMC11740669__F2 Ferritinophagy regulatory network influences ferroptosis sensitivity 2495 2512 7942 2475 9817 26234 4520 472 8924 8673 8031 PMC11740669__F3 Mitophagy resists two forms of cell death 2475 8408 7942 139341 664 65018 581 114548 1687 79792 2879 8031 PMC11740669__F5 Innate immune system regulates two types of ICD through autophagy 7099 4615 115004 2879 114548 29110 5428 8031 9113 79792 PMC11740669__F6 LMP with STAT3 signaling pathway promotes pyroptosis and ferroptosis 114548 115004 79792 1687 3916 1509 1508 6774 8031 PMC11741906__F4 Effect of differentially expressed miRNAs related to cisplatin resistance on PI3K-Akt signaling pathway 613 930 6651 572 5934 5728 PMC11741906__F5 Effect of differentially expressed miRNAs related to cisplatin resistance on MAPK signaling pathway 1610 2316 10000 1616 4149 51701 PMC11742290__F2 LGR5 in the WNT/Beta-catenin pathway 1499 8549 54894 84133 324 4041 4040 4609 595 PMC11742494__F2 CHI3L1-induced tumor angiogenesis, growth, migration, invasion, and inflammation 1116 4318 3576 3598 960 4087 4088 PMC11742494__F7 CHI3L1’s role in the pathology of Alzheimer’s disease through modulation of neuroinflammation 1116 7124 6774 PMC11742855__F4 Сomplex interplay between cell cycle-related genes and their influence on various signaling pathways in NETs 4072 596 4613 2146 1019 7345 1048 5979 3925 8788 1956 2475 253260 PMC11743317__F6 Signaling pathways of duck RIG-I in gene-edited DF1 chicken cells 57506 3661 4599 3665 3659 7098 7706 PMC11743450__F3 Deregulated cell signaling pathways targeted by Bergenin 6774 2475 7099 4193 3091 PMC11743488__F1 TGFB pathway signaling in MFS 7939 7046 4050 PMC11743681__F1 Cellular and Molecular mechanisms regulating Neural Crest (NC) cell migration and polarity 387 998 7204 5879 7852 1265 5754 PMC11743736__F1 Lipid metabolism pathways and promising targets for breast cancer treatment 1376 355 4023 5091 3949 3156 6713 84680 47 PMC11744640__F6 Molecular mechanisms of SARS‐CoV‐2‐induced pulmonary fibrosis 59272 7113 3458 54209 PMC11744640__F9 Important signaling pathways involved in fibrosis 7048 7046 3590 3611 5465 6608 1499 115004 22926 468 7494 PMC11744640__F8 Canonical and noncanonical TGF‐B signaling pathways 7048 7046 4087 4088 4089 4092 9618 387 2475 PMC11745087__F2 Outline of the interplay between m6A modification and radiation-induced injury effects on distinct normal organ tissues (created in Figdraw) 51441 56339 2308 54890 3146 10644 7003 114609 79068 57721 54206 PMC11745087__F3 Newly elucidated regulatory mechanisms relevant to RNA m6A modification (created in Figdraw) 142 56339 6908 4782 57121 10643 10664 8570 22803 6657 5715 2475 9739 8140 10644 PMC11745089__F2 Relationships between gut microbiota, gut microbiota-associated metabolites, and EGFR/VEGFR/KRAS pathways 8213 1950 1956 8829 2475 6667 4703 PMC11745090__F7 IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages 3717 3716 1956 6774 PMC11746911__F1 Canonical and non-canonical Smad signaling pathways induced by TGFB 4089 5879 998 5062 PMC11746911__F2 VEGF signaling pathway 7410 2475 1003 1499 1435 PMC11746911__F3 Wnt/Beta-catenin and NFKB signaling pathways 7099 4041 4040 23411 4615 324 1499 PMC11747284__F4 Schematic represents the PRLR signaling pathways, including both long and short isoforms 5618 3717 3667 2534 2885 PMC11747344__F6 Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation 673 5979 7175 10342 1499 581 51426 595 2475 6009 7249 3667 5879 6850 613 930 11140 5934 5728 84188 572 4151 4193 PMC11747375__F1 Molecular targets and mechanism of action of GA in hyperlipidemia 948 572 581 355 7124 4843 6720 2167 7350 5225 PMC11747375__F2 Inhibition of atherosclerotic lesions by GA 26073 50507 387 998 283455 PMC11747375__F3 GA inhibited the proliferation and migration of VSMCs 387 998 5879 355 5728 283455 983 PMC11747557__F5 Active components of Radix Codonopsis promote lung cancer cell death and inhibitinvasion and metastasis 2885 8717 7186 7188 5163 842 572 PMC11747557__F6 Active ingredients of Radix Codonopsis exert anticancer effects in gastric and livercancer 619501 4280 581 PMC11748510__F10 Scheme summarizing the inhibitory effect of baicalein on PRRSV infection 2813 2814 6714 1956 PMC11748645__F5 PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPA/SYK/FcGR signalings in tumor associated macrophages 6774 4609 8205 6850 961 140885 PMC11748645__F8 PD-L1 monoclonal antibody improves left ventricular function by modulating the CD47/SHP2/SIRPA/SYK/FcGR signaling pathway in tumor-associated macrophages, thereby inhibiting cGAMP expression 961 6850 115004 3661 847 114548 PMC11748936__F7 SIGLEC11 promotes M2 macrophage polarization through AKT–mTOR signaling and facilitates the progression of gastric cancer 114132 2475 7040 PMC11749133__F2 Impact of traditional Chinese herbal preparations on cancer pathways 7099 4615 3725 7124 PMC11749133__F3 Astragalus-mediated inhibition of tumor growth 2069 5873 1499 355 10365 PMC11749133__F4 Immune responses by bufalin in cancer therapy 5966 64127 23657 10645 PMC11749302__F3 Selected results of natural product-based nanomedicines against liver disease 4478 51083 4352 51366 PMC11749404__F1 Synthesis of Phospholipids in association of ER to mitochondria 5662 5091 10400 283871 54675 PMC11749514__F5 Role of the key gene set in the signaling pathway in PI3K-AKT 2475 6009 3667 5879 613 6850 930 373073 951 5728 5163 5934 572 4193 8027 10379 2670 PMC11750270__F8 Therapeutic potential of monomethyl fumarate and aluminum ion combination in alleviating inflammation and oxidative stress in psoriasis 9817 4280 4094 1728 PMC11750448__F4 Network view depicting hub metabolites, their associated miRNAs, and the target genes within the corresponding metabolic pathway 1558 339896 2686 2628 570 2571 1571 PMC11751205__F5 Autophagy pathways in normal and burned tissues 55669 84749 9804 65018 664 PMC11752968__F2 Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases 22926 7186 7494 468 PMC11753526__F6 Type I interferons attach to their receptors, causing tyrosine kinase 2 to phosphorylate tyrosine and activate STAT1 and STAT2 7297 6773 3661 PMC11754051__F7 Interferon alpha production by the MAGUK-family protein CASK under H5N1 infection 3665 8573 3055 1020 10575 8711 8148 10963 4397 PMC11754067__F1 Structure and formation mechanism of KL-la, KD-la and Kce 5163 3939 2739 8841 22933 PMC11754069__F1 Intrahepatic network and metabolic signaling in NAFLD 3795 47 55902 4547 9451 22926 2081 7494 PMC11754069__F2 Extrahepatic organ-specific networks associated with NAFLD 181 4852 5443 9575 26291 6678 2695 9965 9420 8213 PMC11754255__F1 CCL2/CCR2 axis and its associated signaling pathways 6347 729230 2475 6778 6774 PMC11754255__F2 Primary role process of CCL2 in fibrotic diseases 6347 4854 7124 6366 1238 59272 PMC11754404__F7 The effect of Formononetin (FMN) on porcine oocyte in vitro maturation and early embryo in vitro 9973 5743 5742 960 847 9817 PMC11754522__F1 Ceramide biosynthesis pathways (created by Figdraw 2 355 91012 79603 29956 10715 204219 1674 6611 64781 PMC11754522__F3 Mechanisms by which nutritional interventions alter ceramide metabolism (created by Figdraw 2 204219 91012 29956 10715 79603 1674 6611 338 PMC11754893__F8 Mechanism diagram of MH regulating S100A8-CAMKK2-AMPK axis against cerebral IR injury 6279 581 10645 PMC11755046__F9 Synergy between the LINC01419/miR-8070/RAD51AP1 axis and HBV in HBV-associated HCC 103352670 102465870 10635 PMC11755879__F1 Molecular mechanisms of NLRC5 regulation of NFKB and type I IFN pathways and MHC I gene expression 3716 3717 84166 57506 6772 29110 3661 3659 8625 PMC11755879__F2 Functions of NLRC5-dependent domains 54472 6693 3661 84166 8453 595 6774 25942 2167 920 PMC11755879__F3 NLRC5 in cancer 1499 619501 7422 84166 9522 7503 100422829 4009 PMC11755957__F8 Cellular response in bovine sperm after frozen-thawed 4803 1191 3002 11315 9588 PMC11756006__F1 Molecular signaling of nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 priming and activation 4615 114548 140609 79792 PMC11756006__F2 Molecular and cellular signaling pathways of nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 in obesity, diabetes, and other metabolic diseases 7097 7099 948 114548 3458 PMC11756206__F2 Development of gastric cancer is induced by H 7124 6774 7004 7003 1499 PMC11756206__F3 Aberrant Wnt/Beta-catenin, STAT3, and Hippo/YAP signaling pathways activation in H 7124 1956 3558 6010 6774 4485 60485 6714 9113 1499 PMC11756206__F4 Signaling pathways regulated by H 7124 1956 999 1499 5163 324 PMC11757137__F1 M5C modifications in immune signaling regulation 57506 85495 29110 54888 3661 3665 7097 10333 7096 7099 7100 51284 51311 54106 7098 115004 11219 4615 7187 2879 55695 PMC11757636__F3 Influence of autophagy on the progression of pneumoconiosis 7099 2475 2621 2002 23211 355 PMC11757636__F4 Influences of apoptosis and pyroptosis on the progression of pneumoconiosis 114548 79792 355 581 83939 PMC11758636__F9 Lin28b-let-7 Modulates mRNA Expression of GnRH1 Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells 389421 3760 2475 3814 PMC11758792__F1 Lung TME chip operation principles 3569 920 3458 PMC11758808__F5 Biosynthesis of ncAAs 51091 118672 79596 3385 PMC11758815__F8 Iron signaling 5093 5094 8031 7018 57192 960 654 2242 4086 4090 57817 PMC11758815__F9 Copper signaling 540 538 51248 283537 960 5250 1956 11315 9973 475 4504 6648 2475 1737 1743 6647 PMC11758815__F11 Cobalt signaling 54822 867 4397 PMC11758948__F9 Cell division regulation by the EphA2–Ephexin4–RhoG signaling pathway 1969 983 391 PMC11758981__F1 Gut microbial regulation of lipids reflects the influence of gut microbiota on hyperlipidemia in various treatment methods 27329 8213 4023 55908 PMC11759193__F7 Mechanistic overview scheme of the effects of aircraft noise on endothelial function 1392 8452 968 9817 27035 PMC11759460__F7 Graphical abstract 7942 3920 5426 PMC11759867__F1 Action of eCIRP in hemorrhagic shock 7099 54210 4615 PMC11760113__F1 Metabolism of glutamine between normal cells and cancer cells 6510 23657 8140 54407 81539 83733 27165 2746 2806 84706 PMC11760447__F1 Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application 1431 38 3155 5019 PMC11760468__F1 Ras signaling and its involvement in myeloid malignancies 9846 3717 2885 4763 5900 2932 2475 572 1499 1977 2002 2322 4352 PMC11760605__F2 This diagram represents a schematic overview of the MAPK pathway, comprising three principal activation branches: RTK, ERK, JNK activation nodes 3569 2885 5894 2002 1386 6772 9261 8550 7867 PMC11760869__F1 Role of the IHH/PTHrP signaling pathway in regulating chondrocyte hypertrophy 3549 5727 6608 860 4322 PMC11760869__F2 Roles of the WNT, BMP, and TGFB signaling pathways in regulating chondrocyte hypertrophy 652 650 4041 4040 4086 4090 4087 4088 324 4089 1499 4322 860 6662 176 PMC11760869__F3 Roles of the hypoxia, inflammatory (NFKB and VEGF), FGF, YAP, and mTOR signaling pathways in regulating chondrocyte hypertrophy 860 2475 4322 PMC11761133__F5 Functional model of resilience 9314 2670 54715 55083 6750 5816 5205 5649 627 4915 285 7010 84894 PMC11761272__F6 Protective effect of HDH against IAV via activation of the innate immune system 3454 3455 3716 7297 6772 6773 10379 115004 3669 3661 23410 PMC11761653__F11 Seq2Hybrid recovers Ilamycin G BGC 2271 1431 275 95 100187761 PMC11761900__F1 JAK/STAT signaling pathway and the selective inhibition of JAK1 by upadacitinib in inflammatory bowel disease 7297 3716 3717 3718 PMC11762533__F1 Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion 3082 6774 1499 2549 1398 PMC11762533__F2 Impact of HGF/c-MET Signaling Pathway on Immune-Suppressive Cells and Their Interactions: Immune-suppressive cells primarily include CAFs, TAMs, MDSCs, and Tregs 3082 6774 383 1116 8205 9242 9965 2264 2116 2118 PMC11762533__F3 Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion 5976 3082 383 6774 PMC11762533__F4 Effect of aberrant activation of the HGF/c-MET signaling pathway on PD-L1 expression in various tumors: increased PD-L1 expression in NSCLC by activating the downstream pathway PI3K-AKT-mTOR 3082 2475 6775 346389 54918 6772 PMC11762646__F6 microRNAs regulate pathways by targeting multiple genes 6667 6720 8202 3488 3479 3667 5728 4087 4088 5163 207 1581 1374 19 PMC11762942__F3 Amino acid metabolism in chondrocytes 4312 6662 4942 PMC11763227__F4 FGF19 alleviates LPS-induced hepatocytes apoptosis associated with AMPK activation in vivo and in vitro 100187761 2353 9965 PMC11763227__F7 FGF19 working model 1581 1582 9965 2264 PMC11763285__F5 Regulatory pathways controlling cell proliferation and differentiation 8216 998 4771 2475 6016 51004 6598 5058 64423 6722 PMC11763662__F1 Various cell signaling cascades involved in breast cancer 1499 4087 4088 324 4089 8650 1956 6608 6774 2735 2737 2736 2475 1950 6790 PMC11763662__F3 Culmination of signaling pathways in the tumor stroma microenvironment involving cancer-associated fibroblasts (CAFs), adipocytes, and mast cells 6347 6352 2919 857 2247 1950 2191 5156 4312 2921 58191 9235 948 2171 2167 6355 PMC11763662__F5 Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review 3099 5214 7040 7048 3601 6774 154075 3717 6376 2919 6657 6935 9332 79923 6347 3131 PMC11763662__F6 Representative molecular targets in breast cancer, along with the corresponding immunotherapeutic and targeted treatment approach 1956 1950 5163 1019 1021 6714 2885 324 PMC11763799__F1 EGFR signaling pathway scheme 1956 673 5728 4609 2475 1950 6774 1869 PMC11763799__F3 RAS triggering processes in cancer cells 3569 2921 1019 1021 4609 2305 3660 7422 2475 PMC11763988__F4 Antioxidant role of butyrate in promoting animal health 581 9817 1728 847 PMC11764055__F2 Mechano-transduction pathways regulating YAP/TAZ activity 26524 9113 4771 4485 55233 92597 PMC11765076__F1 Aerobic glycolysis in cancer 5315 2821 1356 2597 PMC11765076__F2 Pentose phosphate pathway and its connections with our metabolic pathways 2539 22934 7086 5226 6120 6888 PMC11765076__F4 Serine metabolism pathway 26227 29968 5723 6470 6472 7298 1719 PMC11765076__F5 Proline metabolism pathway 8659 4942 5625 5184 PMC11765076__F6 Tricarboxylic acid (TCA) cycle or Krebs cycle 6389 6390 6391 6392 2271 4191 1431 8802 8801 50 3419 3418 3420 3421 4967 1743 1738 PMC11765393__F1 Insulin signaling pathway in a healthy human brain 126669 2885 8660 3667 2475 4899 PMC11765430__F7 Schematic diagram illustrating the molecular mechanism by which lactate promotes granulosa cell autophagy via the HIF-1A/BNIP3/Beclin-1 signaling pathway 596 664 3939 PMC11765629__F6 Metabolic pathway genes and metabolites altered in patients with MacTel 79603 10558 1719 9517 2646 2645 26227 5723 4548 27232 635 4524 1373 875 PMC11765784__F2 Mechanism of amino acid signal sensing in PCa 220001 4553 10985 6009 468 PMC11766336__F2 lncRNAs regulate the progression of malignant brain tumors 440823 100287616 100885779 100506211 728655 283131 285908 4609 101927152 100130776 750 378938 PMC11766572__F1 MYD88 and IRAK signaling pathway 51135 3654 7189 4615 7124 PMC11766595__F9 TLR4 inflammatory pathway 7189 23118 114548 3929 7099 114609 3661 1386 834 PMC11767231__F1 CBM complex controls T cell signaling by the mammalian target of rapamycin (mTOR), nuclear factor kappa B (NFKB), and c-Jun N-terminal kinase activation (JNK) 84433 79092 2475 10892 146206 PMC11767231__F2 The JAK/STAT pathways contain various factors, including STAT5, which leads to myeloid activation, or STAT3, which upregulates transcription of the gene ZNF341 6772 6774 6777 3716 3717 84905 PMC11767231__F4 Inborn Errors of Immunity Presenting with Early-Onset Severe Atopy 146206 7454 7456 10095 81704 940 PMC11767263__F1 Exercise alleviates sarcopenia by regulating multiple signaling pathways 3479 1499 2932 324 252995 6009 9927 7350 PMC11767460__F7 Association Analysis of the Genomic and Functional Characteristics of Halotolerant Glutamicibacter endophyticus J2-5-19 from the Rhizosphere of Suaeda salsa 8039 5624 1200 55272 6652 PMC11767473__F1 Importance of mesenchymal stem cells (MSC) in the bone-formation mechanism 861 9242 55576 3199 23411 2308 860 468 654 7480 PMC11767564__F2 Metabolic or disease regulation by LEAP-2 antagonism of GHSR1a in human organs 116842 6347 181 4852 2475 4088 7076 1277 112609 2645 PMC11768203__F2 Virulence factors of Fusobacterium nucleatum 7124 2919 4615 330 201633 999 7099 PMC11768235__F1 Exosome-mediated communication between immune cells and keratinocytes contributes to the development of psoriasis 10562 56300 11009 PMC11768371__F7 Mechanism underlying the gedunin-mediated inhibition of C 7097 4615 114548 PMC11769378__F3 Activation of TLR2 signaling pathway by bacterial lipoproteins (BLPs) 4615 114609 7097 7189 7124 PMC11769711__F3 NF‐KB signaling pathway and NLRP3 inflammasome in AS 5970 4615 7189 114548 3066 2627 PMC11769711__F2 Canonical Wnt signaling pathway and targeted therapy in AS 1499 4041 4040 324 2627 6662 PMC11769711__F1 Canonical and noncanoical TGF‐B signaling pathway and targeted therapy in AS (BMP signaling pathway is not shown) 961 7939 4092 4087 4088 4089 2475 9518 9353 26291 7018 22933 1616 6418 PMC11769711__F4 Mechanistic models of AS 114548 4615 4312 1490 10631 999 PMC11769975__F1 Mechanisms by which Fusobacterium nucleatum may contribute to colorectal carcinogenesis [This figure was created using MedPeer (www 5058 7099 1499 7476 7477 7483 595 4609 999 7124 4615 5728 PMC11769975__F2 Fusobacterium nucleatum reshapes the tumor milieu in CRC cells and immune cells [This figure was created using MedPeer (www 383 8205 1950 201633 7124 2920 6348 PMC11769975__F5 Apoptotic effect and immune invasion of Porphyromonas gingivalis in OSCC [This figure was created using MedPeer (www 572 114548 581 6774 PMC11770092__F9 Hypothetical model 147804 5936 5971 PMC11770381__F5 Neutrophils in CAC 4318 2879 6098 6774 6651 2919 57126 3486 PMC11770925__F4 Components-disease-target gene-pathway network 30835 836 4624 2950 3815 6462 4321 3320 55869 7124 3481 3717 367 4942 23569 1890 1969 3718 998 1803 8972 655 2053 6352 3643 4313 7052 2641 5468 4282 2597 10724 5914 410 100 6714 4843 2172 6524 2582 1956 132 5465 4137 PMC11770944__F3 Relationship between common targets of wogonoside and AS therapy and the top 15 enriched targets of the KEGG signaling pathway 27040 5879 5970 5743 7124 2100 2099 5144 100187907 4049 472 PMC11771116__F3 Putative pathophysiological mechanisms leading to the incidence of amyloid-related imaging abnormalities (ARIAs) in the brains of patients with Alzheimer’s disease (AD) 715 716 721 348 7076 4318 PMC11771162__F3 Statins exhibit pro-angiogenic properties 6010 4088 650 PMC11771717__F1 KRAS signaling pathway functions differently in normal cells compared to cancer cells 1956 2885 3845 PMC11772327__F1 Proposed biosynthetic pathway of LC‐alkanes pentadecane and heptadecane in Pogostemon cablin 27349 355 9350 PMC11772333__F5 Biosynthetic pathway of three representative pyrroles 210 7390 130749 7389 4255 5447 5279 PMC11772370__F1 Metabolic crosstalk between neurons and glia involving lactate is implicated in epilepsy 7416 292 3146 114548 PMC11772370__F3 Protein lactonylation modification is an important influence in the process that is HIF-1-mediated HMGB1 activity 4615 2475 5728 6778 3146 7097 7099 5230 PMC11772949__F3 The RLR adaptor MAVS mediated by protein palmitoylationIn the RLR signaling pathway, CPT1A interacts with ZDHHC4 to promote MAVS palmitoylation at Cys79 5879 841 11074 8737 254359 57506 55146 1374 55625 PMC11772949__F5 RLRs induced by protein palmitoylationNLRP3 palmitoylation is induced by ZDHHC7 but suppressed by ABHD17A at Cys126 8878 948 64127 25921 5538 81926 55625 2194 114548 10392 29800 23390 84885 79575 PMC11772949__F6 Pattern recognition receptor signaling by palmitoylation 7124 4615 948 158866 253832 998 10392 57506 115004 55625 25921 51114 5874 4893 PMC11772949__F7 Pattern recognition receptor signaling by palmitoylation 114548 25921 27293 3606 79792 55625 79683 51114 PMC11772949__F8 Modulation of JAK-STAT signaling by palmitoylationIn the JAK-STAT signaling pathway, JAK1, JAK2, STAT1, STAT3, and STAT5A can be palmitoylated 6774 6772 84885 51304 55625 254887 25921 2670 340481 3716 948 3717 6776 6773 3454 2932 29801 3627 55146 PMC11772995__F6 Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway 1325 1392 627 2475 1641 PMC11773722__F9 Graphical summary of disrupted immune and structural milieu in the intestinal epithelium of Mpj and Lpr mice 4280 3603 5132 941 3815 PMC11774878__F2 EMT in TNBC metastasis 5396 91746 27303 4088 9493 2305 2932 PMC11774878__F3 Crosstalk between ferroptosis and EMT in TNBC metastasis 999 4771 26524 9113 7037 7291 2182 6935 10797 1000 2879 PMC11774878__F4 Functions of non-coding RNAs that target ferroptosis and EMT in TNBC metastasis 55288 6774 4306 7391 23657 10866 2879 56899 PMC11775980__F2 Lipid Pathways Located at MAM 10558 9517 5662 38 6770 706 6319 PMC11779860__F6 Mechanistic diagram of HF against HAPH 5111 595 1021 4087 4088 PMC11779893__F6 Possible mechanism of AMLN diet and exercise on mitochondrial homeostasis during MASLD development 8192 9361 468 26291 PMC11780521__F5 Metabolic reprogramming in fibrogenic HSCs activation in chronic liver diseases 54209 6868 5916 5915 3949 7099 4041 255738 7067 7494 38 10682 1277 PMC11780528__F9 Working model for the signaling pathway controlling the formation of SGs in yeast under 2-DG treatment 5004 5005 51690 PMC11781165__F3 Gut microbes and metabolites mediate various signaling pathways related to AP progression 79792 4615 7097 5879 55054 9474 9140 1611 64127 10392 331 114548 PMC11781169__F7 Proposed mechanism underlying TRIM32 in enhancing neuronal ferroptosis after SCI 22954 472 2879 PMC11781172__F1 Novel representative therapeutic targets for SCLC 201633 3902 6790 10683 961 PMC11781175__F8 AS III induces autophagy and activates the nuclear translocation of Nrf2, resulting in the accumulation of p62 and autophagic flux blockade 9817 10413 4094 PMC11781520__F1 MiR-29s in the signalling of innate immunity 7097 7100 64127 207 4513 51284 51311 4615 3569 7124 6347 941 942 7297 6773 3716 6772 8651 6778 3717 10379 PMC11782130__F7 Location and role of Gtl2-Dio3 target genes in the Wnt and PI3K-Akt signaling pathway 7448 6696 1288 5649 1293 3911 1946 284 1942 2252 285 3479 2263 1969 7010 4804 5156 1956 2690 3455 9180 6423 6422 6424 27123 388336 149345 613 4041 4040 6850 3667 8313 23533 5579 1499 5295 4638 387 8395 7088 7091 PMC11783064__F3 Molecular-signalling pathways activated by methamphetamine contribute to cardiotoxicity 51024 596 134864 9817 581 PMC11783322__F6 Protein-protein interaction (PPI) analysis (A) PPI network analyzed through STRING web site (www 140805 1432 5595 3845 7454 4690 387 10552 PMC11784099__F9 Antiviral activity of myricetin against pseudorabies virus through regulation of the type I interferon signaling pathway 115004 3665 3661 3716 6772 10379 6773 9636 4938 PMC11784343__F6 The figure shows the PI-PLC protein, which participates in the IP3 and IP4 synthesis pathways and mobilizes calcium to regulate cell reactions and proliferation requiring free calcium 7291 999 1499 9905 PMC11784353__F10 Schematic diagrams illustrate how EIAV negatively regulates RLR pathway activation by degrading MAVS 57154 57506 3661 29110 PMC11786022__F7 Mechanism of TGFB activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation 1017 1019 1021 983 3098 2335 999 PMC11786412__F7 Reconstruction the sex determination regulatory pathway involving amhr2 269 268 54361 1761 3291 PMC11786704__F6 Schematic illustrates the signaling pathways involved in wound repair 2642 2641 5091 3725 581 4513 PMC11786704__S1 Preparation and application of PC capsules for promoting wound healing in diabetic mice 5091 4280 581 4513 PMC11786761__F9 SH2B1 promotes apoptosis in diabetic cataract via p38 MAPK pathway 25970 581 596 PMC11786765__F7 MRNA expression of different signaling pathway genes 51176 54361 4087 4088 4089 PMC11787113__F2 Phenotypic and functional characteristics of tumor-infiltrating B cells determine their overall impact on tumor progression or suppression 50943 920 8205 PMC11787465__F4 Intricate signaling pathways and functional networks of miR-23 in tumor cell biology 6367 5728 27253 860 619501 6307 355 3090 2744 7421 1012 9817 378938 6387 PMC11787465__F5 Functional roles of miR-23 in organ development 1499 3037 8452 860 23314 6424 60674 3151 5728 PMC11787699__F1 YAP/TAZ in soluble biological signals in bone 4018 4087 4088 4089 6010 4485 4090 4086 PMC11787754__F1 PINK1-dependent mitophagy 65018 10133 9927 55486 PMC11787754__F8 EA treatment might activate the mitophagy-related PINK1/Parkin signaling pathway through lncRNA-XR_002789763 65018 10133 9927 55486 PMC11788002__F1 Galactose metabolism and proposed pathophysiology 2584 2582 2592 PMC11788143__F2 Signalling pathways in pancreatic and peripancreatic cells whose abnormalities cause diabetes of the young at maturity (MODY) 51094 2645 3767 6833 8462 5078 6928 3172 3651 222546 640 3630 7248 7249 6009 2475 PMC11788431__F8 C1GALT1-mediated regulation of Hh signaling and EWSR1::FLI1 expression 6608 51684 2736 2735 2130 PMC11788444__F4 Iron dysregulation in the lysosome and mitochondria of PD 7018 7942 8031 55669 9927 94033 1356 PMC11788642__F8 Schema of Rnf111 regulating the development of hematopoietic stem and progenitor cells by maintaining Smad2/3 phosphorylation and activating the Gcsfr/NO signaling pathway 4087 4088 4089 4092 1051 PMC11788965__F1 Simplified brassinosteroids (BR) biosynthesis and signalling pathways 1362 5243 578 51411 7358 57716 PMC11789227__F3 Therapeutic potential of SOX family transcription factors in osteoarthritis 23411 51547 6662 1999 57713 7874 5717 6387 7852 1499 8091 79727 PMC11789495__F5 MTORC1 signaling pathway extensively controls cellular metabolism 8408 7942 3091 221937 468 2539 3099 5634 790 6733 226 7167 2618 5198 5230 26227 55276 471 2023 29968 5723 6472 10797 25902 PMC11790428__F1 Signaling pathway of NOD1 10392 6010 55054 7187 3553 3665 PMC11790448__F1 Adropin regulates multiple signaling pathways 387 3717 5728 6774 627 2842 2876 23411 5166 1375 4023 PMC11790539__F2 Pyroptosis signaling pathway 79792 1687 2475 PMC11790539__F3 Necroptosis signaling pathway 197259 8717 8737 PMC11790539__F4 Autophagy signaling pathway 64422 9474 673 54502 2475 2309 PMC11790539__F5 Ferroptosis signaling pathway 23657 2118 2879 100302158 PMC11790539__F6 Cuprotosis signaling pathway 2230 699 472 6122 PMC11790572__F1 Shared immunopathologic mechanisms of the atopic march 64806 90865 85480 7040 PMC11790812__F3 Apoptosis of tumor cell induced by Dioscin 472 581 572 PMC11790812__F4 Dioscin regulating autophagy in tumor cells 9101 7052 2475 PMC11790818__F3 Notch signaling pathway 5045 100188776 4609 PMC11790847__F1 Multiple post-transcriptional modifications regulate cancer progression via manipulating the activity of the Hippo signalling pathway 56339 219333 285629 2683 4485 51441 26524 9113 PMC11791038__F7 FAM210B inhibits the proliferation and metastasis of lung adenocarcinoma via interacting with TOM70 and promoting IFNA/B production 57506 116151 3661 6772 10379 3437 PMC11791101__F1 Normal activation mechanism of hedgehog signaling pathway 6608 51684 2737 2736 374654 2619 2121 132884 2735 8643 PMC11791101__F2 Autocrine of the hedgehog signaling pathway 6608 374654 91653 2619 51684 898 894 2305 4613 182 2249 7422 596 2735 8643 PMC11791101__F3 Paracrine of the hedgehog signaling pathway 4803 374654 91653 2619 6608 2520 51684 596 8643 898 894 182 4613 2305 2249 PMC11791135__F6 Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation 6009 7249 1975 613 5879 930 11140 5728 5624 672 5934 572 150365 4602 PMC11792030__F1 CoQ biosynthetic pathway 3652 27235 22796 51805 51117 84274 PMC11792170__F1 Some immune cells regulated by IL-27 10148 920 355 6774 2625 6772 7124 6773 6775 3002 PMC11792170__F2 Part of IL-27 signaling pathways in obesity and other related metabolic diseases 920 6774 2475 324 7350 3717 19 PMC11792405__F3 TSC1-TSC2 complex in ovarian GSCs, Nephron progenitor cells and ISCs 7248 999 84133 4040 324 1499 4609 PMC11792562__F4 Pathway map of differentially expressed genes involved in cytidine synthesis across the comparison groups: A glycolytic pathway; B TCA cycle; C cytidine synthesis pathways 6389 6391 6390 PMC11792562__F5 Pathway diagrams of differential metabolites related to the cytidine synthesis pathway in the comparison groups: A glycolytic pathway; B TCA cycle; C cytidine synthesis pathways 6389 6390 6391 6392 PMC11793009__F9 Potential regulation loop of MET and ETS collaboration 374 3082 7852 PMC11794540__F8 The mechanism by which endothelium-derived AGGF1 attenuates ischaemic retinopathy 55109 890 595 983 8742 PMC11794838__F9 HU protecting against DKD in this study 3569 3383 7412 581 PMC11794924__F3 Molecular mechanisms of granulomatous inflammation for sarcoidosis; Antigen-presenting cells, like macrophages and dendritic cells, initiate phagocytosis of antigens 920 2833 30009 1234 6364 1235 6778 3603 3716 6772 50943 3717 6774 7297 2475 90865 PMC11795048__F1 Design and application of A@HAP NPs in cancer therapy 594857 3146 6774 920 PMC11795593__F7 Transcriptomic and metabolomic-based revelation of the effect of fresh corn extract on meat quality of Jingyuan chicken 253782 8877 166929 PMC11796038__F8 CTSB induces ferroptosis via SAT1-mediated lipid peroxidation, mitochondrial damage and MAPK signalling pathway activation 2879 6303 1508 PMC11796190__F7 Diagram highlights the distinct mechanisms by which EA and MA modulate hypothalamic function in PCOS 80320 3688 7046 4087 PMC11796622__F5 IL17RA mutation and downstream signaling pathway 84818 10682 7189 PMC11797775__F2 The main cell signalling pathway mechanisms reportedly disrupted by hyperglycaemia-associated oxidative stress and AGEs in MSCs, osteoblasts and osteocytes, potentially contributing to impaired bone healing in T2DM patients 324 847 5163 2475 860 PMC11798966__F1 Proposed mechanisms of NLRP3 inflammasome activation and regulation in HBV infection 7099 114548 79792 PMC11799081__F1 Apoptosis and Necroptosis 79792 8737 8772 PMC11799259__F2 Interaction between genes/pathways in prostate cancer (A) Rb deletion promotes the expression of genes downstream of the AR pathway through transcriptional activation of E2F and facilitating promoter recruitment of the AR 4609 367 5728 PMC11799769__F4 Correlation network diagram between renal‐secreted proteins and proteins on the most significantly altered KEGG pathways in skeletal muscle 4698 4702 4701 4712 5004 6300 65260 54205 64077 4729 8991 3976 3913 3912 3421 3911 4191 3419 1605 3908 6696 8802 207 208 3240 PMC11799893__F3 Transcriptome analysis of isopentanol synthesis pathways 2147 25874 51660 5132 PMC11800460__F7 Graphical abstract image illustrating the mechanism of EPN3-mediated EGFR stability and its role in NSCLC development 1950 55040 1956 PMC11800603__F2 Innervation in gliomas promotes tumor growth 627 54413 6714 2885 2475 PMC11800603__F3 Several example mechanisms of therapeutic avenues of cancer neuroscience: A Inhibit of ADAM10/NLGN3 can suppress glioma growth by targeting its downstream PI3K-mTOR signaling pathway 54413 102 627 4803 PMC11800652__F5 Metabolic maps of Sulfurovum species from Kebrit Deep BSI 5447 8634 4842 PMC11802338__F2 TNF‐A/TNFR1 mediates the major signaling pathway of necroptosis 23118 7124 7186 8717 8772 730 PMC11802338__F3 Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation 197259 192111 11035 PMC11802527__F2 Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure 114548 345 3554 79792 8737 388325 4067 6850 PMC11803289__F2 How S1P works 1901 9294 1903 8698 53637 PMC11803499__F2 B cell signaling is integrated downstream of activating receptors to regulated B cell‐specific cellular functions and B cell fate decisions 613 958 930 973 974 7189 7187 6850 4067 7186 5163 695 253260 64798 2475 5970 5971 7248 7249 6009 847 1977 4615 54106 51284 PMC11803499__F4 Inhibitory receptors modulate the PI3K/AKT/mTOR pathway to influence B cell fate decisions 958 613 253260 64798 7248 7249 355 6009 933 5728 PMC11804041__F11 SNHG involved in a serious of cellular biological role in EC 2475 4851 8434 387066 60674 641638 23642 6659 388796 84973 100093630 100507246 85028 57291 102465502 607 PMC11806010__F4 Clec9a-initiated ITAM-Syk signaling cascade and downstream pathways 64170 8915 283420 6850 10892 114548 5971 PMC11806117__F4 Canonical signaling pathways involved in liver repair and regeneration 84133 54894 60485 51523 6608 252839 324 6790 9021 50507 23411 1499 5465 3164 6774 PMC11806117__F6 Lipid metabolism during liver repair and regeneration 1950 9611 2539 1956 3082 2264 2305 2194 4015 595 54894 84133 3156 10221 1581 51141 1499 11315 1965 57708 5728 1374 5465 19 4615 4513 PMC11806117__F7 Amino acid metabolism during liver repair and regeneration 1956 2744 2308 595 2194 PMC11806174__F3 Deciphering Regulatory Networks Governing Seedling Emergence in Deep-Sown Direct-Seeded Rice Cultivation 1356 100187761 103 100 PMC11806588__F2 The potential pathways and mechanisms of genes associated with skin colour-related phenotypes 434 172 4157 27132 6687 3662 10381 54849 1800 PMC11806588__F3 The potential pathways and mechanisms of genes associated with wrinkling and sagging-related phenotypes 63976 10558 6095 8412 9575 PMC11806588__F4 The potential pathways and mechanisms of genes associated with skin cancer-related phenotypes 4026 7015 81037 54796 PMC11806845__F1 Mitochondrial membrane permeabilization results in mtDNA leakage 1843 192111 581 79792 7444 51429 2271 PMC11806845__F5 Dysfunction in mitophagy is closely related to mtDNA leakage 65018 7494 139341 81671 7019 55737 7124 581 PMC11806845__F6 Primary cytoplasmic DNA sensors activated by cytosolic mtDNA 115004 81030 114548 9447 65018 54106 11035 4615 29110 3661 PMC11806886__F5 Combination strategy to suppress tumor cell proliferation in anti-HER2 resistant PTEN-deficient breast cancer cells 5728 948 2475 2194 PMC11807217__F8 Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis 3611 7018 1019 1021 5467 581 PMC11808201__F2 Mass Spectrometry as a First-Line Diagnostic Aid for Congenital Disorders of Glycosylation 23443 5236 4351 5373 29926 29925 79868 29880 116150 79947 79644 22845 8813 8818 54344 11253 5589 23193 91869 10195 29929 84920 1650 3703 201595 84061 7991 58505 6748 6747 9382 25839 91949 84342 10466 83548 22796 57511 60684 55858 147007 7355 4247 2683 55343 197258 7264 64116 6487 537 10159 23545 84317 203547 10559 PMC11808218__F11 Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway 627 7037 2879 23657 PMC11808587__F2 The role of mGlu5 activation in neuropathic pain 3627 6347 7442 8989 PMC11808623__F5 Mechanism of CSEAE regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway (Created with BioRender 207 4597 4280 348 PMC11809005__F3 Reconstruction of the ginsenoside biosynthesis pathway in PN flowers, with expression profiles of structural genes across the six developmental stages 3156 4598 4597 2224 PMC11809008__F9 HSPA1A inhibits pyroptosis and neuroinflammation after spinal cord injury via DUSP1 inhibition of the MAPK signaling pathway 3303 1843 114548 79792 PMC11809362__F3 Major function of RECK: (A) RECK is a metal protease negative regulatory factor: (a) RECK binds to MT1-MMP and binds it to the GEEC-CLIC endocytic pathway for degradation 8434 4313 7476 1499 102 6868 3717 PMC11809390__F8 Constitutive DRD4 activates TGF‐B receptors independent of ligands to promote CRC metastasis 1815 7048 7046 659 4087 4093 4090 4086 182 6615 4089 6418 PMC11810461__F1 MiRNAs that regulate 5-FU resistance in GI cancers 317 23 406971 7465 1844 6935 1871 56852 5091 619501 2638 7298 8651 9021 27250 5728 5925 64881 1848 406935 332 694 1806 2305 100313892 5764 7431 8324 407018 9817 1977 3209 51147 7048 51727 3397 27123 51341 PMC11810530__F1 Pyroptosis signalling cascade in IHD involves a series of events 7099 7187 114548 79792 PMC11810530__F2 IHD‐mediated pyroptosis occurs through canonical, noncanonical and alternative pathways 7099 7187 355 8772 7186 114548 79792 1687 PMC11810975__F3 Synthesis of Primary BAs and Secondary BAs 1593 9420 1581 1582 8213 570 4945 PMC11811070__F1 Pathways to apoptosis 355 7124 8772 8717 7186 581 637 596 PMC11811070__F2 Molecular mechanism of autophagy 2475 8408 9140 83734 9474 10533 64422 PMC11811070__F3 The main mitophagy pathways 65018 10133 664 23786 139341 23770 11331 PMC11811070__F4 Pathways involved in necroptosis 8717 8737 1540 7186 355 11035 8772 197259 81030 PMC11811495__F3 Example of network visualization from the KEGG Pathway database for the “Wnt signalling pathway” (https://www.kegg.jp/pathway/hsa04310), analysed using Orthoweb 59343 10297 6259 4163 5467 11211 PMC11812559__F2 Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases 4087 4088 4089 PMC11813047__F1 STAT3 signaling pathway 3569 6774 6714 PMC11813745__F1 Figure-Schematic illustration depicting the role of Phosphodiesterases in Endocrine system and associated diseases 1636 59272 1267 342538 367 3627 3576 PMC11813773__F2 Dual roles of SBAs in colon cells: anticancer and cancer-promoting effects 8213 4194 4193 10682 1956 PMC11813773__F3 Anticancer effects of SBAs in Hepatocellular Carcinoma (HCC) and Pancreatic Cancer 8213 581 57447 6774 PMC11813976__F2 Molecular mechanisms of STAT3 signaling pathway in CRC 7124 6774 1435 1950 6714 51701 2475 5780 7157 PMC11814165__F2 Illustrating of the binding mechanisms of berberine with PLA2, MD2, BACE1, AB1-42, TGFBR1, and JAK2 in human cells 4615 4512 7099 351 23621 7046 PMC11814332__F9 Schematic depicting the role of CerS6 in ceramide metabolism and innate immune responses 253782 7416 115004 29110 PMC11814419__F6 Schematic for the mechanism by which PGAM1 functions to promote the malignant phenotypes of BC via the Wnt/Beta-Catenin signaling pathway 5223 1499 2932 324 PMC11814426__F1 miMOMP activates mtDNA-cGAS-STING pathway and promotes cellular senescence and tissue aging 581 3569 3552 PMC11814453__F2 High salt or sodium ions on immune cells in the tumor microenvironment 6778 2475 58484 114548 3002 4049 55509 7099 4843 383 6774 PMC11815446__F1 Metabolic pathway of Clopidogrel 1557 1544 1555 1559 PMC11815730__F3 Hippo signaling pathway components in mammals 4485 60485 26524 9113 10413 7004 PMC11815735__F9 Proposed mechanism elucidating the involvement of EBV in oral cancers encompasses the regulation of host cellular lncRNA LINC00944 387895 3659 3663 6348 6772 941 4283 3627 PMC11816580__F1 In MASLD, CS affects the AMPK signaling pathway in different ways in the liver (A), adipose tissue (B), and ileum (C) to perturb lipid metabolism 4353 9817 23411 847 2475 355 7038 55512 3667 PMC11816580__F2 Molecular mechanism of CS-induced hepatocellular damage 284106 4199 7124 367 355 8772 581 596 847 1571 4843 3596 79792 114548 PMC11816580__F3 Downstream signaling in regard to the promotion of liver fibrosis by CS 7124 1431 54361 1856 6774 4087 4088 4092 7076 2932 4313 1277 1281 4089 1499 PMC11816596__F1 Canonical Wnt pathway (left): Wnt ligands (such as Wnt1, Wnt2, Wnt3, Wnt3a, and Wnt 8) bind to the frizzled (FZD) receptor and its coreceptors LRP5/6 (LDL-receptor-related proteins) 4920 5879 387 2932 324 1499 PMC11816720__F1 Kynurenine pathway (KP) 169355 3620 8564 23475 PMC11816720__F3 Molecular mechanisms of kynurenine pathway in liver diseases 6955 8564 2859 196 1543 23645 PMC11816792__F2 Wounds healing by exosomes derived from adipose stem cells containing lncRNA 378938 283120 283131 7503 60674 100507392 400619 152559 51284 494327 6774 6662 2200 8408 4921 7422 7291 PMC11816792__F3 LncRNAs involved in diabetic foot ulcer healing 103695365 55869 283120 2146 6722 7291 378938 400619 152559 9314 128408 768097 255082 PMC11816803__F9 Figure illustrates simplified pathways involved in the development and progression of EC based on KEGG BRITE data (BRITE accession ID: K04503, pathway map ID: map05213) 5728 842 572 3611 2885 324 1499 581 51426 PMC11817128__F6 Target protein involved in NGF-NTRK1 signal transduction controls key protein targets 4803 4914 2885 4513 6770 PMC11817190__F3 Influence of micronutrients on bone metabolism 9242 860 50964 22943 5741 PMC11817496__F9 The apoptosis signaling pathway triggered by PM2 5053 8717 8772 7186 581 9049 841 843 836 842 840 PMC11817781__F4 Top 10 genes and associated critical phenotypes network 3162 5327 59341 4312 4088 2668 6513 8878 5328 PMC11817786__F5 Integrative multi-omics data analysis, including DEGs, DEPs, and DElncRNAs 3630 5837 10512 2905 5590 7249 3691 3914 PMC11818536__F3 Tumor suppression and promoting mechanisms of LACTB 7291 389 2879 23657 114294 2475 PMC11818554__F2 Wnt Signaling in MSC osteogenesis 7471 7473 7474 7481 50964 4041 6010 324 1499 81030 9242 5091 3725 PMC11818554__F7 Pathway regulating MSC osteogenic differentiation 5741 6608 1499 4087 468 860 PMC11818720__F5 Carbohydrate metabolic pathway diagram 4311 5106 11187 PMC11820109__F7 Cdk5-gated light signal 1020 8864 5187 2669 150094 23373 PMC11820142__SF7_3. Graphical abstract 3554 4615 3654 51135 7189 387 6093 9475 59272 PMC11820663__F4 Macrophage polarization-related signaling pathway (by Figdraw) 3566 7099 4615 3661 4087 4088 6774 6772 6778 PMC11820753__F3 Impact of CR on different nutritional pathways indicating how it promotes anti-cancer activity 3479 3480 7248 7249 6009 2475 PMC11820857__F10 In darkness (A), CRY1 remains in its inactive form and is unable to suppress BR signaling because it does not interact with dephosphorylated BES1 64326 1407 907 7956 PMC11820997__F3 Beneficial effects of hydroxytyrosol (HTyr) on insulin signaling through the enhancement of insulin signaling pathways 3553 3569 7124 PMC11821285__F2 Proposed molecular mechanism of ARI in cancer involving modulation of Hippo signaling and Wnt signaling pathway 4485 60485 9113 324 1499 PMC11821611__F4 Biosynthetic pathway of flavor in fresh C 7360 2821 2597 1431 4967 2752 PMC11821632__F1 Canonical and non-canonical TGFB signalling pathways 4087 4089 7046 6885 4088 7189 9618 4092 7018 2475 PMC11821961__F1 Two NFKB signaling pathways include the classical (canonical) and alternative (noncanonical) routes 613 958 4049 4050 4055 6850 4067 7189 7186 3932 695 29760 27040 114609 4615 8717 7187 3654 51135 7188 1540 10454 23118 5971 5970 PMC11821962__F4 WWP1-involved signaling pathways and regulatory mechanisms 8314 4087 688 2066 11059 5728 26994 80762 4609 136259 PMC11821962__F5 WWP1 in different types of human cancers 11059 5728 6925 1499 1021 688 8314 2475 80762 10533 4485 60485 26524 9113 118856 6774 4318 4313 999 136259 4609 4087 79674 PMC11822028__F3 Transcriptomic and proteomic profiles of G. subvermispora and T. versicolor of 4-HBA catabolic pathways, TCA cycle, and glyoxylate shunt under different cultivation conditions 2271 1431 4397 PMC11822051__F6 The proposed mechanism 5091 5338 2475 PMC11822647__F8 Schematic image shows the role of neuronal CTSS in the process of aging and Alzheimer's disease (AD) 4280 1520 6376 1524 3717 6774 PMC11822654__F2 Efferocytosis in immune cells 29933 4609 10461 5879 7409 948 1846 1788 5743 4513 PMC11822654__F3 Impaired efferocytosis in aging 961 100133941 10461 558 7301 140885 2621 PMC11823593__F2 Canonical and non‐canonical Wnt signaling pathway 4041 4040 54894 84133 284654 8549 59352 55366 324 1499 22943 6259 23002 387 6010 3725 PMC11824814__F8 Dietary DHA Regulated the Androgen Production in Male Chinese Tongue Sole Cynoglossus semilaevis 6770 3291 3283 3294 3293 3292 PMC11825097__F8 LIPG regulates goat intramuscular preadipocyte lipid deposition through the PPARA signaling pathway 7038 9388 2194 PMC11825590__F4 Portion of the canonical NFKB signaling pathway containing IRAK1 and inflammatory cytokines discussed in this study (IL-1beta, IL-6, and IL-8) 10454 23118 51135 4615 3656 3654 7189 3663 PMC11825788__F2 Neuropeptides released from nerve endings and receptors on GCs are illustrated 79054 7442 59341 10203 7432 7433 6778 25803 1956 4586 3171 3170 54795 29850 PMC11825806__F7 Schematic diagram illustrating the effects of targeted activation of ErbB4 receptor on neuronal aging via ferroptosis inhibition 23657 207 2879 2066 PMC11825815__F2 Macrophages in the progression of CP to PC: M2 macrophages interact with PSCs and contribute to the fibrotic process in the pancreas 100653366 1950 7124 1956 6774 PMC11826106__F9 CSRP2 inhibits the necroptosis of glioma cells by activating the JAK-STAT1 signaling pathway 8554 1466 6772 11035 8737 197259 PMC11826472__F2 After PNI, several cellular changes are observed in the spinal cord, the injury site, and target organs 7124 1435 2670 PMC11827473__F6 Anti-tumor effects of ArcA on the aggressive behavior of metastatic melanoma cells 1019 4318 4322 PMC11827847__F10 Hypothesized mechanism by which NRP1 mediates NGF/TrkA pain signaling 4803 8829 10755 PMC11827889__F1 TrkA/NGF/NRP1/GIPC1 targeting for pain treatment 4803 100187761 8829 10755 PMC11828848__F4 Enzymes of energy metabolic pathways divergent in UGT2B17-deficient livers 2645 9563 56886 7086 5091 PMC11828970__F2 Simplified pathways of ammonia metabolism and treatment 162417 1373 4998 5009 435 PMC11829435__F7 Proposed model showing the mechanism of combined HDAC and FLT3 inhibition 2322 4280 9241 472 5888 7465 947 PMC11829548__F2 Toll-like receptor signaling pathways 10333 7097 7100 54106 4615 51284 51311 51135 3654 3656 7189 10454 23118 257397 7099 114609 7187 3663 3661 3665 7098 PMC11829561__F4 Metabolic reprogramming in the tumor microenvironment 1373 445 435 PMC11829765__F8 Lineage diversification in the ureteric mesenchyme 6469 7477 652 8854 93649 PMC11830326__F2 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers 4087 4089 1499 6935 9839 PMC11830326__F3 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers 1499 3714 2335 51176 2625 PMC11830326__F4 Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers 4087 4088 3611 2932 1499 4089 387 10342 6591 9839 6935 999 PMC11830326__F5 Dietary phytochemicals targeting Wnt, TGFB, JAK/STAT, NOTCH, PI3K, and TNFA signaling pathways involved in EMT transitions 7124 5163 2475 2625 4087 4088 79923 PMC11830326__F6 Signaling pathways involved in repurposing drugs in cancer therapy 1611 847 6774 2475 4193 PMC11831194__F3 Neuroprotective role of OPN in Alzheimer's disease pathology 4035 4615 6850 54209 PMC11831195__F3 Molecular docking of PD and targets 5743 5054 3383 6774 4314 3162 4846 PMC11831438__F10 Scheme depicting the proposed mechanisms for the neuroprotective effects of Tat‐Nrf2 peptide treatment in ischemic stroke 26054 2729 6648 PMC11831484__F10 Fatty Acid Oxidation‐Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica‐Induced Pulmonary Fibrosis 51 1374 3099 5213 PMC11831486__F3 Tumor type‐specific protein network profile 6714 5880 3673 2335 387 2317 2318 2316 1280 10398 51083 9844 2783 94235 54331 2786 2790 2788 57580 5894 7057 5747 83660 7414 7058 1278 10000 7448 7143 1277 2309 5106 3563 7249 2475 2776 4000 1501 4131 4133 3880 2931 1808 2932 3183 1832 1452 119 1495 3856 4082 8660 1500 5037 3875 PMC11832533__F9 Brief Introduction to the Functions of lncRNAs (Wilusz et al 643911 55000 4174 100303491 5347 2146 10890 PMC11833111__F5 Correlation analysis of differential microbiota, metabolites, proteins and FST 10468 375775 79888 5168 59084 PMC11833784__F5 Schematic representations of energy metabolites and enzymes involved in glycolysis, TCA cycle, ETC and AMPK pathway in ileum of layer pullets 7019 1431 4899 PMC11834262__F8 Graphical abstract illustrating the mechanism of SS in treating BC 3550 1956 23657 2879 PMC11834690__F1 Production of insulin and the classical insulin signaling pathway 5728 5163 7248 7249 6009 PMC11834966__F3 Action of PRMT3 and CARM1 in different cancer 10196 5820 10498 3091 3939 2475 619501 3178 2597 57721 4781 4190 2182 2879 2146 4609 7422 2638 7942 4350 5210 7528 5054 9209 55038 1499 8451 7982 PMC11835119__F4 Phyllanthus emblica–active components–target–pathway network 6095 4306 1654 6715 846 4915 6323 51567 6331 51305 57704 3611 6046 3417 132 1508 2936 10188 6505 11255 249 2912 2950 8242 4985 2166 706 1557 2597 2260 2897 6335 1845 3767 1859 7124 2645 3359 1136 8973 6532 150 1129 9429 1128 1131 6531 2561 3312 1142 5138 151 7422 4282 4988 1141 836 1137 6462 2903 3352 2562 763 2915 3358 2559 1139 3763 4137 3760 43 2550 351 3350 2554 5743 2555 1457 135 367 2475 134 673 1020 4318 5894 5290 5595 5604 207 2566 5594 781 1544 2081 6774 7150 766 768 771 759 4129 7442 7364 1565 2914 4363 5243 2902 4128 2556 5602 11238 761 2932 23632 765 PMC11835119__F7 Exploring the mechanism of action of Phyllanthus emblica in the treatment of epilepsy based on network pharmacology and molecular docking 51738 2693 10911 2837 799 3814 551 5724 1392 4295 2862 2695 2696 51052 2834 7200 7201 5367 2492 2692 3972 187 100506013 7253 4018 5741 2925 6344 1241 718 347148 727 2908 7425 5739 2690 5021 3953 6865 80763 6870 PMC11837068__F7 Schematic diagram illustrating that lncRNA H19 positively regulates S1PR3 expression by disrupting HDAC2/H3K27ac binding in EPCs 1903 283120 100188864 3066 PMC11837473__F1 Integrated stress response signaling pathway 1998 4553 468 PMC11837473__F2 Mitochondrial dysfunction and ISR: The activation of the integrated stress response (ISR) during mitochondrial dysfunction is triggered by various mechanisms 468 9812 115209 PMC11837473__F3 Integrated stress response in neurodegenerative disorders 3458 6647 4397 57761 468 PMC11837477__F10 EGFR roles in fetal and postnatal pancreas development 1950 685 1956 1839 6868 6714 5163 2475 5879 PMC11837477__F13 EGFR roles in lung fibrosis 1950 374 6868 1956 5163 PMC11837477__F2 EGFR ligands and signaling pathways activation 1950 685 374 1839 255324 7039 6868 2069 6714 1956 5163 867 PMC11837477__F3 EGFR role in the placenta development 1950 1956 4318 4313 6774 5163 3399 3814 PMC11837477__F4 EGFR roles in IECs proliferation and gut regeneration 374 998 1956 2069 3716 5163 6774 PMC11837477__F5 EGFR roles in liver regeneration and fibrosis 1839 7039 374 26137 6868 8213 1956 6714 1581 5163 6774 PMC11837477__F6 EGFR roles in bone development 7039 1839 2475 650 1956 3480 10216 3486 4086 PMC11837477__F8 EGFR role in brain development 1950 1839 1956 6469 6774 8650 6657 5163 PMC11837477__F9 EGFR role in T cell regulation 374 1839 90865 1950 920 3458 PMC11837758__F1 The metabolic pathway for the biosynthesis of monocyclic aromatic chemicals 5805 85569 7498 7504 7086 1312 1756 PMC11839352__F4 枸杞多糖改善高原低氧环境雌性大鼠生殖损伤的机制研究 1956 1066 8242 3320 2539 983 54583 5467 768 3960 5300 598 5581 1374 6774 2222 5583 8841 6505 2247 140 4986 993 2203 5243 4313 1889 476 4988 3958 3098 3558 2346 1588 10825 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2021 572 581 637 355 8772 PMC11840414__F1 Steroidal glycoalkaloids biosynthetic pathway in potato (Solanum tuberosum) and tomato (Solanum lycopersicum) 643847 643834 25801 PMC11840736__F2 Epigenetic regulation-mediated disorders in dopamine transporter endocytosis: A novel mechanism for the pathogenesis of Parkinson's disease 627 9026 8301 PMC11840835__F3 Diagram of mechanisms of glucose controlling the fate of blastocyst 2475 10413 7022 7004 1045 PMC11841260__F3 Application of spatial transcriptomics to rheumatoid arthritis 2191 6279 4314 3569 4345 PMC11841418__F1 3D printed magnesium silicate/Beta-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis 4397 860 2932 1499 PMC11841850__F1 Heme biosynthetic pathway and multisystemic manifestations in EPP and XLP 212 2235 5498 1371 210 7390 7389 PMC11842143__F1 Developmental signaling pathways regulating osteoblast differentiation 650 652 5228 6608 4041 4040 1499 3516 4086 4090 100188776 4089 6662 860 PMC11842281__F4 PI3K‐AKT signaling pathway by nSolver Software (PathView) 2475 6009 7249 1975 3667 5879 6850 613 930 5728 5934 572 4602 4193 PMC11842293__F7 Mechanisms by which OPC mitigates LPS-induced renal tubular injury 847 581 7124 PMC11842335__F2 Underlined molecular mechanism during mastitis development 8452 9817 847 7124 PMC11842335__F3 Activating the Nrf2/KEAP1 signaling pathway to counteract oxidative stress and subsequent inflammatory reactions, including mastitis, induced by LPS through the administration of bioactive compounds from an external source 8452 9817 847 7124 PMC11842356__F2 Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics 115004 29110 3661 6352 3627 7124 PMC11842380__F12 Signaling pathways that the exosome may regulate 4117 942 941 3566 PMC11843152__F7 NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis 1869 983 23397 891 2475 PMC11843235__F6 Working model for ADAM10 in lung cancer 1000 999 4318 102 4851 PMC11843251__F11 Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis 284207 2879 2182 PMC11843905__F14 STRING network of FREM2 8828 9638 1996 9435 143162 64403 1950 2064 3485 255743 340481 158326 3688 256158 83872 23426 123169 23139 9119 219874 10579 160762 340277 341640 2065 7386 7223 25975 10531 57486 7064 342527 55966 2066 7020 63929 115209 26519 6259 PMC11844033__F8 Graphical Abstract Under hypoxic conditions, JUN enhances the transcription of EGLN3, which subsequently binds to HUR to positively regulate the stability of EGFR mRNA 112399 1956 3725 PMC11844283__F7 Schematic model illustrating the mechanisms by which DSF/Cu activates innate immune signaling pathway to enhance anti-tumor immunity and potentiate therapeutic responses to PD-1 checkpoint blockade (created with BioRender 115004 29110 3661 6352 3627 3458 PMC11844401__F1 Four-step protopathway (highlighted in lilac) restores growth of ΔpdxB E 7068 3651 8566 4860 PMC11845729__F5 Expression pattern of differentially expressed genes involved in the Wnt signalling pathway, an ancient and evolutionarily conserved pathway regulates the cell migration, polarity, neural patterning and organogenesis during embryonic development 51701 84445 100306940 2160 324 4089 50964 4088 57805 6500 8161 387 9475 PMC11846447__F4 Muscle protein regulation through the mTOR pathway 2475 3479 3667 7249 6194 PMC11846535__F1 This figure illustrates Canonical (SMAD dependent) and Non-canonical (SMAD independent) TGFB signaling pathways 4087 7048 7046 6010 2475 PMC11846535__F2 Exploring TGFB Signaling in Cancer Progression: Prospects and Therapeutic Strategies 1950 3082 5727 6608 324 2475 PMC11846535__F4 Diagrammatic summary of therapeutic strategies and agents (light purple) targeting the TGFB signaling pathway 4089 4087 4088 PMC11846620__F6 Molecular Mechanisms of Immunoinflammatory Infiltration and Ferroptosis in Arthritis Revealed by a Combination of Bioinformatics and Single-Cell Analysis 2937 6520 23657 2879 2182 10162 7018 55240 1356 5094 94033 2147 5093 9474 10533 8031 PMC11847137__F9 Schemic working model revealing the possible role of ZC3H15 in mediating BCP 55854 9817 1728 2729 PMC11847233__F1 Regulatory effect of lncRNA Erdr1 on T cells 6364 920 1235 581 PMC11847347__F6 Cancer-secreted exosomal miR-1825 induces angiogenesis to promote colorectal cancer metastasis 100302183 3621 4087 4088 PMC11847631__F3 Expression of inflammatory mediators induced by pathogen invasion 4615 7099 7124 6347 PMC11847756__F2 PPI network was constructed using STRING to visualize the interactions among the 140 shared targets between Chrysin and breast cancer 4282 4843 3627 50943 6868 5644 4312 6462 1244 412 3292 6817 1548 5465 174 1545 4363 196 5970 4316 4313 6774 5243 3725 4792 4088 5328 1499 2932 2260 387 331 7161 6790 1495 1031 5111 25913 80824 7031 PMC11847756__F3 Topological analysis of the PPI network using Cytoscape identified 10 key hub genes, shown in this network visualization 3725 7157 3091 207 213 836 7124 3569 596 6774 PMC11847854__F3 Saikosaponin A-target-pathway network 3725 1956 596 5879 3558 3091 2932 1017 2247 5781 367 5743 2321 5770 598 3791 3480 4313 5347 7422 1545 PMC11848126__F4 CK2 signalling pathway, highlighting interactions that regulate canonical initiation 5170 5728 207 8864 1408 9575 406 1981 10146 468 1975 1973 23367 7048 7040 8668 2001 8669 8665 8666 4690 PMC11848126__F2 MTOR signalling pathway, highlighting mTORC1 and interactions that regulate canonical initiation 5170 207 8408 6009 1408 5728 9575 2475 4686 23367 468 23178 1915 84232 27250 29904 1612 1938 3476 PMC11848412__F5 A, Schematic illustration of how calcium dysregulation in the aging association cortex leads to activation of calpain‐2 and an exacerbation in sporadic AD pathology 6093 3984 351 1020 6262 PMC11848799__F2 Monocyte eukaryotic initiation factor 2 signaling differentiates 17-hydroxy-docosahexaenoic acid levels and pain 1998 83939 10278 100188776 26986 4118 100187761 5978 PMC11849169__F1 Pathway for triterpenoid saponin biosynthesis in S 3652 157739 5132 PMC11849169__F5 Construction of a biosynthetic pathway for CK production in S 2023 1832 3652 2078 PMC11849288__F4 Expression profiles of genes in starch and sucrose metabolism pathway 2353 412 2444 2821 4602 PMC11849638__F9 Schematic depiction of the PKA/SHP2/STAT1 pathway 3454 3455 5144 7297 10399 6773 3716 6772 10379 4513 PMC11850271__F1 TNF-Alpha-driven formation of necroptosis-specific protein complexes 10010 8737 8717 7186 23118 197259 8772 11035 PMC11850271__F2 Regulatory role of posttranslational modifications in the activation of RIPK1 1540 9825 10133 29110 8737 8717 57162 8772 11035 23118 257397 PMC11850813__F7 Molecular mechanism underlying knee arthrofibrosis 1490 1956 1803 3371 PMC11851453__F1 Two-end black (TEB) coat color phenotype, schematic diagram of EDNRB transcripts and their encoded protein, three-dimensional structure prediction of the EDNRB protein, and an EDNRB melanin pathway diagram 1910 1906 4286 PMC11851563__F1 Canonical Wnt signaling pathway 2932 324 1499 PMC11851563__F2 Beta-Catenin and DNA repair pathways 1499 6477 6925 472 2932 545 6996 4255 7507 3146 1045 2067 5111 2237 7515 3980 142 4436 2956 4437 4605 672 3276 675 4292 5395 5888 7855 9156 8607 5318 3981 7518 PMC11851658__F1 Pexophagy-related peroxisomal proteins 5830 5194 9409 1962 8504 5195 2475 PMC11851658__F2 ROS function as signaling mediators in pexophagy 472 5830 7942 5828 PMC11851696__F7 Expression profiles of DEGs in pathways related to IAA, GA, and ABA hormones and reactive oxygen species accumulation 140805 7018 100187761 PMC11852824__F10 Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth 4893 673 572 2353 581 PMC11852866__F8 ITIH5-mediated fibroblast–macrophage crosstalk exacerbates cardiac remodelling after MI 80760 960 6774 383 PMC11852910__F4 Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies 8312 5728 154796 29117 57506 142 6662 PMC11852910__F5 Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer Therapies 142 80351 81847 3091 PMC11852973__F1 Tumor-derived double-stranded DNA (dsDNA), which can be derived by genomic instability, activates AIM2 inflammasome and cGAS-STING signaling pathway 9447 115004 3661 PMC11852973__F3 Therapeutic strategies targeting the AIM2 inflammasome in cancer 9447 2247 5132 3627 PMC11853202__F5 Schematic diagram displaying APOL1RRV-mediated downstream signaling pathway leading the activation of the RAS and participating in the progression of CKD 406968 7421 7490 PMC11853215__F7 Proposed simplified signaling pathway elucidating the mechanism underlying the amelioration of steatosis induced by Exendin-4 2740 355 7376 4547 33 100187761 2305 378938 999 983 7852 6935 PMC11853266__F4 Advanced glycation end products (AGEs) induced inflammatory cell signaling pathways 1729 114609 387 5879 998 PMC11853266__F5 TLR4 signaling pathway in DPN 7099 4851 4615 1540 3280 PMC11853365__F1 Multifaceted roles of ApoE4-induced Glial dysfunction in Alzheimer’s disease pathology 4035 114548 834 3569 PMC11853510__F2 Mechanisms of bioactive materials and cytokines in regulating inflammation and maintaining pulp equilibrium through various signaling pathways involving the nucleus [70,71,72,73,74,75,76,77,78] 7054 8717 6955 324 5163 3565 PMC11853522__F3 Interaction between nutrient-sensing pathways and mitochondrial oxidative stress and chronic inflammation 23411 51547 51548 115004 23410 10234 65018 2475 3630 3479 3480 847 PMC11853609__F9 Schematic model of the mechanism by which PHF8 promotes malignant phenotypes and immune escape of KRAS- or BRAF-mutant CRC cells 23133 3106 6890 3105 3665 3659 6352 673 3845 PMC11853667__F1 mTOR signaling pathway in cells 5728 253260 64223 2475 89780 7248 7249 6009 8408 PMC11853774__F1 Crosstalk between the Hedgehog (Hh) and PI3K pathways in hematological malignancies 6608 51684 2735 2932 2322 2475 2296 PMC11853781__F4 Multi-pathway mechanisms of luteolin in inhibiting colorectal cancer 999 9817 1956 114548 PMC11853788__F4 Proposed regulatory network involving relevant metabolic pathways in Longissimus dorsi muscle (LDM) after composite plant extracts (CPE) addition 5295 5091 1509 581 26279 123745 5163 1506 1363 PMC11853802__F2 Schematic diagram summarizing the possible involvement of the GnIH system in endocrine axes and peripheral regulation 1392 5443 4852 7200 2638 7054 PMC11854110__F2 Action of circRNAs participated in the chemotherapy resistance of cancer 4904 4087 4088 6774 6794 7482 3570 5894 10114 1499 693222 4089 PMC11854242__F4 Rho/ROCK/MRTF/SRF transcription pathway and its upstream regulation by the actin cytoskeleton in liver fibrosis 4018 387 6093 9475 6714 6722 1277 PMC11854242__F5 YAP-mediated gene expression in liver fibrosis 4018 387 4485 60485 9475 26524 9113 6714 27063 1277 PMC11854242__F6 Mechanosignaling via Integrins: Pivotal Players in Liver Fibrosis Progression and Therapy 7939 4087 4088 4089 1281 59 PMC11854354__F2 Signaling cascades generalized for ubiquitin-mediated IKK activation in IL-1R/TLR and TNF pathways 51135 4615 3654 7189 23118 257397 81858 7124 8717 7186 10133 PMC11854354__F3 Ubiquitin-mediated IKK activation and Bcl10 autophagy in the T cell signaling pathway 3932 7535 8915 10892 2522 PMC11854358__F7 Proposed effect of low-dose PFESA-BP2 exposure on the hepatic fibrosis signaling pathway in the liver [59] 1956 4609 890 983 332 3479 PMC11854358__F8 Analysis of cell cycle pathways and differentially expressed genes because of different levels of PFESA-BP2 exposure 1019 4085 1958 10460 8835 1894 9055 90427 4609 4171 890 983 1017 7153 PMC11854358__F11 Hypothesized mechanistic diagrams for the effect of PFESA-BP2 exposure on EGF signaling and JAK/STAT signaling based on previous supportive studies 1950 1956 1958 2885 6464 8835 5770 619501 2475 3725 4790 1051 PMC11854592__F2 The EpCAM signaling pathway in cancer progression 4072 1956 6868 2274 1499 51176 PMC11854632__F1 Effects of miR-21 on key signaling pathways involved in SCI, with a focus on axonal regeneration, apoptosis, and inflammation 4803 627 1270 1271 572 581 6774 595 2670 4092 8772 5728 841 4920 2475 836 1499 27250 PMC11854706__F6 Signaling pathways induced and inhibited by ACE 1499 1956 2932 3845 5290 5295 8312 8313 5879 324 1636 5728 7124 8717 207 8772 572 841 843 56288 84552 84612 50855 836 840 596 595 894 896 54205 317 842 PMC11854763__F2 Signaling pathways directly and indirectly linked to RhoA/ROCK-mediated activation of GSK3B and the positive feedback loop between AB deposition and GSK3B activation 4040 351 387 6093 9475 6714 23621 5728 PMC11854789__F1 Mechanism and Applications of Vagus Nerve Stimulation 7124 6774 3717 627 10220 581 PMC11854957__F1 Transcription Factor CcMYB330 Regulates Capsaicinoid Biosynthesis in Pepper Fruits 1312 275 1431 PMC11855067__F3 Core genes of key signaling pathway map of tectoridin against ischemic stroke 6009 2475 7249 1975 2885 3667 8480 613 930 951 5934 5728 572 4199 4193 PMC11855089__F8 Comprehensive analysis of metabolomics and network pharmacology 3007 1559 55364 3008 3009 341567 3010 3006 PMC11855151__F5 Antigen processing and presentation pathway (KEGG: 04612) displaying DE gene expression between AU and EU and the influence of the top-ranking lncRNAs in the prostate 7503 7124 3458 821 811 6892 567 414777 1508 1514 1520 920 791114 6546 PMC11855151__F6 displays the chemokine signaling pathway with all top-ranking lncRNAs and their interaction with pathway genes 126669 2885 791114 414777 7503 572 5978 8863 1398 387 PMC11855151__F9 Antigen processing and presentation pathway (KEGG: 04612) displaying gene regulation of AF vs 7124 3458 6616 2160 821 6892 26512 3991 1508 920 PMC11855151__F10 Chemokine signaling pathway (KEGG: hsa04062) illustrates gene regulation differences between AF and EU prostate cancer patients, highlighting the influence of lncRNAs identified through structural equivalence analysis 126669 50652 572 2312 1794 998 387 2160 6616 PMC11855193__F2 ApoA-I regulates blood sugar 10682 3651 3667 PMC11855299__F6 SMG modulates OBD by regulating the activity of both transcriptional and metabolic pathways 650 23411 1374 PMC11855393__F2 AR and associated pathways and their potential inhibitors in triple-negative breast cancer (TNBC) 367 2475 1019 1021 5728 PMC11855393__F3 Cancer stem cell-associated pathways and their potential inhibitors in triple-negative breast cancer (TNBC) 5754 6774 4041 4040 1499 4089 4087 4088 11319 PMC11855393__F4 EGFR, FGFR, PI3K and MEK pathways and their potential inhibitors in triple-negative breast cancer (TNBC) 1950 1956 5728 2475 PMC11855393__F5 Targets of immunotherapy in triple-negative breast cancer (TNBC) 201633 3902 942 941 PMC11855511__F8 Construction of DEmiRNA-mRNA expression regulatory network based on JAK-STAT signaling pathway and phagosome 7506 4942 7504 PMC11855587__F1 Endogenous Specialized Proresolving Mediators in Mast Cells and Their Involvement in Inflammation and Resolution 9415 60481 3992 54898 PMC11855613__F1 Diagrams summing up the pathogenetic pathways relevant to BBB disruption in TBE and discussed in the paper 4282 7124 4317 4318 4314 4316 PMC11855671__F6 Biosynthetic and signal transduction pathways of SA 4881 4883 3242 PMC11855704__F2 Application of MAPK, PI3K, and JAK/STAT signaling pathways in the pathogenesis of obesity 3667 4852 181 5443 7350 7351 1734 4925 3479 PMC11855704__F3 Wnt/Beta-catenin pathway in the pathogenesis of obesity 4041 6774 1499 51523 147111 9885 6259 387 7350 118 PMC11855906__F1 Comprehensive scheme for the complex regulation of cardiac non-selective autophagy in HFD-induced metabolic cardiomyopathy 10533 9370 4485 217 9140 2475 9474 596 8408 100187761 PMC11855906__F2 Comprehensive scheme for the complex regulation of cardiac non-selective autophagy in STZ-induced metabolic cardiomyopathy 4485 284207 8737 2308 10533 145957 2475 596 8408 3920 PMC11855906__F3 Simplified scheme for the regulation of cardiac selective autophagy in HFD-induced metabolic cardiomyopathy 6423 8408 7942 283120 23476 5340 7030 6774 8031 10533 10313 7095 PMC11855906__F4 Mechanistic insights and multifaceted applications of autophagy as a potential therapeutic target for metabolic cardiomyopathies 4485 8737 596 10135 217 65018 8408 6423 6774 2495 8031 7095 10313 284207 1984 PMC11856057__F1 General mechanisms involved in Notch signaling 6868 102 84441 55534 9794 3280 PMC11856057__F2 Signal transduction in the Hedgehog (Hh) signaling pathway 84976 2619 91653 374654 51684 6608 2737 2736 2932 11127 PMC11856472__F3 Crosstalk between Wnt, Notch, TGFB, BMP, and Hedgehog signaling pathways 2932 81839 57216 5727 6608 144165 166336 4087 4088 5879 387 4090 4086 4089 324 1499 4609 3280 23462 PMC11856986__F6 Associations between stroke and vascular dementia combing Mendelian randomization with network pharmacology 1956 6774 5290 5728 572 3082 126669 2885 7039 673 581 558 PMC11856996__F3 Inhibitory Effect and Mechanism of Hexanal on the Maturation of Peach-Shaped Phallus impudicus 3240 5728 5266 6094 717 57534 PMC11857241__F1 During neurodegeneration, critical pro-inflammatory and oxidative molecular pathways are involved in the occurrence of neurodegenerative conditions 7124 3383 7412 23411 PMC11857241__F2 Our manuscript denotes the neuroprotective effects of many phytochemical classes, including those from flavonoids and alkaloids, against neurodegeneration 23411 114548 8651 PMC11857725__F2 The metabolic pathway of tryptophan and phenylalanine in ADHD 1644 15 438 5053 130013 8942 7054 1621 5409 1312 PMC11857948__F9 Selected differentially significant signaling pathways in M 3929 3575 7099 920 55540 1441 9180 4615 5879 6774 5292 2475 2920 2919 3576 4513 6364 4318 4314 PMC11858609__F3 Illustrates the NFKB signaling pathway, highlighting the role of pro-inflammatory stimuli such as LPS, IL-1, IL-36, TNFA, and PAMPs, which activate receptors (TLR4, IL-1R, TNFR) to initiate intracellular signaling cascades 7099 3654 7189 4615 3656 8717 8737 7186 PMC11858609__F6 Illustrates the MAPK and NFKB signaling pathways activated by pro-inflammatory stimuli such as LPS, IL-1, IL-26, TNFA, and PAMPs 5226 4513 7099 PMC11858609__F7 Effects of bioactive compounds on periodontal bone remodeling 650 860 4772 PMC11860879__F1 Signaling pathways in the immune TME in AOC 7124 7186 3717 6774 8205 4117 941 942 940 2920 PMC11860879__F2 Multiple signaling pathways in the non-immune TME in AOC 538 540 1956 2885 126669 1499 472 2932 545 2475 4209 PMC11860879__F4 Applications of NPs to reverse the non-immune TME in AOC 574456 594857 672 4209 PMC11860889__F1 Activation or silencing of WNT signaling pathway in the presence or absence of WNT ligands 1 999 1499 4041 4040 324 7291 PMC11863469__F10 PI3K/AKT/mTOR pathway in GBM progression 1977 64223 64798 5728 7248 7249 6009 572 PMC11863469__F12 Notch signaling in GBM progression 26508 23462 23493 3280 5728 PMC11863469__F16 Complex and dynamic interactions between signaling pathways in shaping GBM progression, therapeutic resistance, and disease outcomes (*To draw this figure, data from the reports in references [39, 146, 155, 245, 249, 294, 333–380] were used 1956 3479 673 960 998 387 5879 780 PMC11863469__F17 SHH signaling pathway in GBM, particularly in GSCs: In the absence of the hedgehog (HH) ligand, the Ptch receptor inhibits Smo, leading to the formation of GliR, a repressor that suppresses the expression of target genes 6608 51684 6469 PMC11863469__F3 Signaling pathways in GBM 2475 324 23440 545 472 4193 PMC11864756__SF1_3. Analyses of differentially expressed genes that were enriched at different timepoints 7124 100187907 7975 2353 1847 1848 11221 351 PMC11865046__F7 TMYXP's key blood components and mechanisms for treating the elderly CHD 836 7040 5743 3576 7124 355 3717 1147 598 5925 6198 3326 7046 2950 3685 3676 939 PMC11865073__F3 Neuroinflammation signaling pathway activity and member DEGs from mThy1-Alpha-synuclein overexpression at 7 months 6376 4280 2904 6387 6352 2890 4137 2561 2560 9586 6538 6622 6850 4780 3416 3162 3458 4314 4827 51284 3627 942 51135 91 3146 7124 7471 353376 7187 3665 2932 3661 2705 1499 5743 6347 596 23621 3586 4908 4803 3606 3565 4318 1401 958 8837 29108 834 1524 PMC11865073__F5 Neuroinflammation signaling pathway activity and member DEGs from mThy1-Alpha-synuclein overexpression at 10 months 6376 54209 7305 4280 5743 6352 355 6850 6622 9568 4318 11213 941 4615 1536 330 93 2563 3458 4827 3146 3606 7124 7471 3554 353376 114609 3416 3162 5979 8321 2932 29110 3661 2705 1499 6347 2668 596 4908 3569 3565 8837 958 29108 834 1524 7054 PMC11866596__F1 TREM1 signaling pathway 2885 54210 7535 6850 7189 3717 6774 64170 4615 PMC11866803__F10 Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer 1499 2254 27161 23002 387 9475 PMC11866848__F4 SLC7A11 inhibiting ferroptosis in cancer cells 6541 239 2879 PMC11866848__F6 Research progress of disulfidptosis in the TME 23657 9817 920 468 PMC11866848__F7 Relationship between disulfidptosis-related pathways and ICIs 2744 3099 5879 3662 1958 PMC11867957__F1 Classic Wnt/Beta-catenin pathway cascade diagram 4041 4040 324 1499 PMC11868049__F1 Ubiquitination in cellular processes of cGAS-STING Pathway 115004 27005 3661 29110 90933 90864 PMC11868049__F2 Downstream effects of the ubiquitination process in the cGAS-STING pathway 115004 7189 27005 29110 3661 581 10206 PMC11868168__F3 Lung cancer metastasizes outward through exosomes 214 5728 5873 10413 23410 6659 PMC11868168__F4 Metastasis from other organs to lungs via exosomes 23135 857 389421 23468 1291 387 9314 10365 6387 100423026 57659 PMC11868327__F3 Molecular cascade of the involvement of GluD2 or GluRD2 in cerebellar cell death 581 637 9474 5091 PMC11868397__F7 Pattern of USP35 negatively regulates the MAVS signaling pathway to attenuate type I interferon production 57506 29110 3661 57558 PMC11868719__F1 Using the String database to analyze protein interactions 4489 4153 7421 2309 10333 23429 55159 7083 5245 8607 8312 25988 23643 7099 3146 6294 5371 10153 353376 3064 26155 4869 7443 50507 114609 1051 1856 8650 9338 5747 55904 7345 7295 55620 3065 56950 2114 10105 5469 55670 4173 23411 6015 8237 25898 142 10389 7629 8431 8772 1387 7157 23113 10075 8503 4691 51135 7097 7178 6721 65057 4088 7534 7316 2033 286514 8805 55872 30827 7584 6477 6045 4193 6925 2810 115426 8405 8833 9612 5300 5347 1155 7965 613 1616 4194 4801 64326 7158 6047 7703 339745 4118 5534 5515 51438 2965 3315 9063 7112 266740 9891 51177 572 90102 83985 78986 7341 29117 147923 11200 7486 6659 8678 27113 7405 596 10197 599 29108 5366 578 10134 114034 6622 581 493856 637 9774 351 4170 6647 6667 8626 5565 6188 PMC11868719__F2 Using the String database to analyze protein interactions 5230 161882 7083 4086 6622 5971 6118 2064 50808 351 1499 2997 51339 2783 29110 26277 6647 7157 636 10522 10153 54946 5566 7248 8312 121340 6615 9817 4843 1956 324 51199 4040 8468 120892 1213 23043 5550 7295 815 23310 6279 3064 158471 64396 2534 51527 4137 4077 6790 57506 5970 5579 4790 2308 6188 301 90485 5590 2194 55620 84914 5493 11140 7431 9815 1540 4176 2475 2309 8878 1017 23411 793 10010 5518 10569 4792 55072 4609 207 890 7128 6714 9616 472 5335 53339 5515 7267 157310 8559 8517 2908 23184 26060 81858 79959 22938 29948 51083 1786 545 10616 6789 9869 7316 6857 8737 1147 5914 171023 7124 1387 154796 23118 3875 51020 8533 80149 84270 84433 8915 10892 27238 64170 84080 602 7341 7186 PMC11868719__F4 Signaling pathway of LPS-induced apoptosis 7099 4615 581 PMC11868730__F3 Drug-active components-common targets-pathways network diagram 2950 3037 3162 3384 2946 3551 2697 3643 2152 2264 2554 2556 2155 6885 2149 1733 3356 1803 4312 7424 1128 1576 3725 2555 5743 1555 4134 26191 1131 1135 4319 4313 1545 4843 1132 4609 1544 154 2159 4846 1129 1543 3326 4988 1812 5530 842 1499 5139 5717 135112 5970 5445 841 983 6331 836 857 4585 5468 6401 5566 840 5644 6514 79957 3747 596 51806 6530 6531 5728 5294 581 240 5742 6532 367 6590 213 7040 147 6775 43 7153 148 207 7124 8644 4684 10598 196 7498 PMC11869728__F1 Canonical TGFB/SMAD and Wnt/Beta-catenin signaling pathway 4087 4088 4092 4091 4089 4041 4040 324 1499 PMC11870059__F8 Metabolic pathway reconstruction graphs of the starch, nitrogen, and lipid in the rumen of sheep fed different forage and grain sources 3006 3005 3008 3024 3007 3009 PMC11870265__F5 MAPK signaling pathways, their activators, and inhibitorsrelevant to this study 1950 1956 2002 PMC11871115__F7 Mechanism of action of polyphenols in Alzheimer's disease (AD) through modulation of the WBC signaling pathway 324 1499 22943 PMC11871217__F7 Deduced signaling pathways regulated by LvMmd2 221938 100505381 5894 152559 572 9113 PMC11871796__F1 Microglia M1 polarization–mediated tic onset 1230 6352 1234 22861 3383 6347 3162 4609 9021 7054 5309 PMC11871796__F2 The possible mechanism leading to Tourette syndrome (TS) associated with the immune response/inflammation 6774 7124 3569 PMC11872079__F8 Schematic model illustrates the role of Sirtuin 5 (SIRT5) in the regulation of follicular recruitment in chickens through its influence on the autophagy-lysosome pathway in granulosa cells (GCs) 2147 2152 2153 23408 3916 PMC11872466__F10 KEGG pathway enrichment analyses of screened compounds in the treatment of AD 351 57142 3416 90550 4023 8772 637 572 842 836 6622 100506742 22926 9241 1020 7054 4041 324 203068 4513 7124 2475 9776 22863 29982 3630 3280 388585 100188776 8650 441478 PMC11872610__F1 Design and preparation of Qu-CDs for the treatment of burn wound healing 999 4090 4086 383 3398 3400 3397 3399 1000 4827 PMC11872695__F1 Illustrates the interplay between gut microbiota, ImP production, and cardiometabolic diseases 6376 26291 8660 1956 PMC11873031__F5 Experimental design, analysis and validation 4280 26995 6418 PMC11873051__F1 Resistance mechanisms to CDK4/6 inhibitors 2195 2064 2260 2261 2263 4763 1019 1021 5728 1017 6790 PMC11873181__F2 Regulation of mitochondrial quality control by PGAM5 55486 4041 4040 1499 324 192111 PMC11873641__F1 Metabolic adaptations in cancer cells 3949 948 355 55902 9415 6319 3418 3417 47 PMC11873641__F4 Intricate signaling pathways linking obesity to cancer progression 3479 3480 2475 4609 3569 PMC11874147__F2 Dysregulation of lipid synthesis and related pro-oncogenic signaling pathways involved in BC development 355 47 3156 1956 19 PMC11874147__F3 FAO signaling pathway and ferroptosis in BC 355 3458 23657 9415 3992 4609 2879 2182 367 6774 9839 1375 PMC11874752__F8 Schematic diagram displays the function of FLJ in CRPC 367 84971 23192 8408 9706 PMC11876172__F1 Signaling pathways and associated genes with mutations linked to hyper-IgE syndrome 3569 7046 7048 6774 6778 84905 55914 84433 8915 10892 7189 23118 257397 81704 PMC11876390__F1 Metabolic pathways of polyamines 5009 2628 4942 384 196743 6723 1984 1725 83475 435 1610 6611 PMC11876490__F4 Enrichment by Gene Ontology (GO) and pathway terms were visualized using the ClueGO/CluePedia plugin from Cytoscape 8615 5699 10591 2512 2597 334 6652 4069 8970 490 7280 860 9978 2932 2036 5111 535 175 9114 3094 5830 6711 PMC11876490__F3 Enrichment by Gene Ontology (GO) and pathway terms were visualized using the ClueGO/CluePedia plugin from Cytoscape 1937 55920 10059 440686 203068 8239 22818 9039 5499 81609 7082 55737 4677 8338 7094 55766 10890 55207 1478 5859 22916 1915 5518 8774 64423 9114 85235 60 23435 1739 71 2673 8546 55269 9521 3987 3013 9775 2617 5901 5520 1983 3376 6455 57403 5869 79834 723790 3065 5048 8331 158078 51095 10672 10980 1509 3482 23499 7919 286451 51493 27068 27044 381 51138 8336 2590 126003 9061 8452 54845 8683 PMC11876573__F3 Association network of differentially expressed genes (DEGs) in the tumor necrosis factor signaling pathway in the organ of Corti in wild-type mice following acoustic overexposure (AO) 468 3726 5600 1051 9021 2353 5608 3725 2919 3976 1435 5743 2920 3553 5970 3627 7132 11035 3383 6401 8809 4323 PMC11876573__F5 Association network of differentially expressed genes (DEGs) in the MAPK pathway in the organ of Corti in Fkbp5−/− mice before acoustic overexposure (AO) 2019 90806 3725 10454 PMC11876573__F6 Association network of differentially expressed genes (DEGs) in the MAPK pathway in the organ of Corti in Fkbp5−/− mice following acoustic overexposure (AO) 11221 5602 5608 1616 7132 3553 7124 22808 8491 25780 781 285 1945 PMC11876635__F7 SEMA3F-dependent pathways 8828 6405 2475 PMC11876862__F1 Mechanisms of protein degradation and synthesis in muscles 664 65018 9140 6774 5682 2475 2660 10220 3479 4086 4087 4088 4090 4089 2170 PMC11877141__F0 Battling pain from osteoarthritis: causing novel cell death 2937 23411 2879 6422 4615 2475 114548 1499 102 9817 10628 79792 115004 1687 7874 50507 2353 1728 7018 8717 8737 7186 55240 8772 136 11035 4609 197259 9780 8989 342538 PMC11877274__F1 Mechanism and site of action of pharmacological agents targeting the IL-17 signalling pathway (figure created in BioRender.com). SABR, single-arm pilot study of brodalumab 149233 132014 84818 55540 7189 PMC11877449__F2 PI3K/AKT/mTOR Pathway 6009 1956 3480 8408 PMC11877449__F3 Interactions in the Tumor Microenvironment (TME) Affecting Lung Cancer Progression 8205 7422 5066 PMC11877844__F6 Possible signaling pathways that are partially stimulated by hCG and induce the synthesis of proteins with cell fusion-activating properties 51094 2475 6286 9590 467 7004 6667 1499 3291 8521 30816 6382 5228 3623 51393 PMC11878248__F2 Predicted targets of host miRNA responsive to HSV-1 infection 100187907 6955 8651 5771 PMC11878481__F1 Autophagy by mTORC1 and AMPK 7249 7942 9474 9140 64422 8408 PMC11878485__F1 The role of signaling pathways in the mechanisms of glaucoma in retinal ganglion cells apoptosis, optical nerve protection and regeneration, and the LC damage and remodeling 627 5728 6010 PMC11878485__F2 Review of glaucoma related signaling pathways and their mechanisms 627 857 5728 572 581 7124 8717 7186 387 5340 PMC11879837__F10 Illustration of the JAK2/STAT3 and PI3K/AKT signaling pathways implicated in the protective effect of SM on kidneys injured by DN 3717 207 2475 6774 7124 581 PMC11879902__F4 Diagram of glycolytic signaling pathway in senescent cells 4609 4193 3939 8660 3667 3099 57103 PMC11879902__F3 Aerobic glycolysis in tumor cells 2303 3099 57103 3939 PMC11880501__F7 Working model 51540 7538 4041 PMC11880705__F3 NS1 in counteracting innate immunity1: Binding of NS1 to p85Beta-SH2 relieved p85B repression of p110a, activated PI3/Akt signaling, and inhibited the apoptotic program induced by influenza virus 7706 4938 6041 3661 PMC11880705__F5 Applications of live attenuated influenza a virus with modified NS1 gene 7098 51284 3661 3665 PMC11880738__F1 Mechanisms responsible for copper uptake and homeostasis in cells 475 9973 6647 5250 10063 6341 9997 1353 538 540 PMC11880738__F5 Dual role of copper in melanoma 6275 9706 8408 84695 9973 673 4286 PMC11880921__F1 Biosynthesis pathway of GD2 (5) 7357 51083 9334 6489 51046 2583 8705 PMC11881607__F1 E3 ubiquitin ligases promote asthma pathology 267 4281 8535 64806 PMC11881607__F2 E3 ubiquitin ligases inhibit asthma pathology 8065 83737 8450 8651 54620 6737 7226 6778 2625 114548 90865 3553 PMC11881607__F3 Deubiquitinases functioning in asthma pathology 9100 84640 29761 7375 3726 580 7124 114548 2625 7187 79184 3066 27005 1540 55611 PMC11881679__F2 AAT is involved in the regulation of the cell signaling pathways and the pathogenesis of disease 8177 4615 412 7186 2885 51135 8772 7189 23118 257397 PMC11881707__F3 Interaction mechanism between intestinal flora and cAMP-PKA signaling pathway in neurological diseases 1312 7166 1392 1325 PMC11881714__F3 Mechanisms of neuronal damage attributable to Cu toxicity 6647 351 7124 PMC11881735__F7 Epigenetic regulation of NFKB and JAK/STAT signaling pathway in SAH 4615 7189 9021 2146 8841 221883 6774 9314 3383 7412 3586 PMC11881760__F3 Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren’s Disease 7099 9447 114548 4615 115004 6774 3661 PMC11881903__F7 Proposed model depicting the process underlying TOD-dependent muscle regeneration 142 6348 6347 PMC11882405__F6 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action 5163 5728 331 3939 3099 PMC11882405__F7 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action 7124 4615 7186 7188 23118 4055 7187 29110 5970 5971 PMC11882405__F8 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action 2885 2104 355 637 572 8844 PMC11882405__F9 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action 472 545 4193 595 23657 1019 2879 PMC11882405__F10 Reversal of chemotherapy resistance in gastric cancer with traditional Chinese medicine as sensitizer: potential mechanism of action 6774 8651 581 PMC11882760__F3 DUBs on periodontal inflammation and bone resorption 220213 114548 8078 1540 6774 10483 928 961 650 219333 7189 140609 3606 9618 PMC11882765__F1 Ferroptosis Signalling Pathway 7018 8031 6520 23657 55240 2879 2643 1719 2182 10162 PMC11883231__F7 Proposed biosynthetic pathway of polyphyllins in P 53366 7911 6747 6745 6746 PMC11884060__F6 Map of the metabolic pathways related to the differentially expressed genes in strains S26 and S26-AE2 under 20 g/L and 100 g/L glucose conditions 2203 2819 2820 5230 2023 2026 6886 PMC11884102__F1 Signaling pathways in fibrotic processes involving macrophages 7124 4087 4088 4089 2475 4320 999 PMC11884491__F7 Schematic illustrates the antiproliferative effect of P 4087 4088 5111 PMC11884773__F1 Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function 8989 79054 7442 999 PMC11884866__F10 Diagram illustrates the role of PCBP2 in immune evasion in prostate cancer 5094 29110 3661 PMC11885102__F4 Schematic diagram of the regulation of intestinal ACE2 on islet function 1636 350383 59272 PMC11885449__F10 Mito-nuclear carbon metabolism in Toxoplasma 4118 324 3418 11113 3417 2271 PMC11885516__F2 Dual role of reactive astrocytes 4920 3280 3554 4851 9475 7124 PMC11885647__F4 Redox regulation of proteolysis 10537 11101 5763 PMC11885647__F5 Redox signaling modulates metabolic reprogramming 10367 221154 90550 3667 3845 5163 5728 7248 PMC11885647__F6 Stem cell exhaustion and intercellular communication regulated by redox signaling 6469 5727 6608 4087 4088 1499 4089 9817 6010 2534 2735 2736 154796 4771 4485 60485 9113 PMC11886387__F3 McCullough protocol: Base spike detoxification 5340 59272 7099 PMC11887407__F4 Oncogenic GNAS activation and downstream signal transduction 1499 324 6469 6608 9113 6714 150094 665 23235 23387 4609 332 10413 6774 2735 595 PMC11889221__F4 Metabolic differences between M1 and M2 macrophages 6510 2752 4144 8205 PMC11889221__F6 Tissue Macrophages in Diseases 6347 3627 6696 3958 8742 6348 6351 6352 54209 351 472 120892 PMC11889322__F3 Diagram depicts the Aryl hydrocarbon receptor (AhR) signaling pathway, starting with the cytoplasmic retention of inactive AhR in a complex with heat shock protein 90 (HSP90), X-associated protein 2 (XAP2), and p23 196 5053 405 1543 1545 57491 PMC11889408__F1 IL-6 family cytokine signaling pathway 3266 6774 3976 1270 5008 3977 9021 2475 7018 PMC11889548__F5 Abnormal Hedgehog (Hh) signal transduction caused by EFCAB7 mutation 51684 6608 132884 84455 2121 2695 4624 1482 PMC11889592__F3 miR-34 family has suppressor effects on cancer invasion, proliferation, and metastasis by regulating molecular pathway 595 9134 596 6935 23411 1956 2668 5156 2674 983 1019 4851 1021 3146 995 5728 581 PMC11889691__S1 Multiscale mechanical-adapted hydrogel for the repair of IVDD 3712 4513 4314 4318 4322 PMC11889768__F11 Potential pathways by which abscisic acid (ABA) influences 2-acetyl-1-pyrroline (2-AP) biosynthesis in aromatic rice 1610 4942 5625 PMC11889768__F1 Biosynthetic pathway of 2-AP 4942 1610 5625 PMC11889778__F1 NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium 4397 4827 6469 5727 6608 2735 PMC11889860__F5 Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies 7097 5879 54472 4615 8772 114609 3929 3550 929 23118 7189 958 942 51135 1513 54106 7297 10379 PMC11889860__F6 Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies 7124 921 914 3627 3600 3569 3976 8717 1540 8772 836 64127 331 197259 717 2353 3725 4314 4312 1906 6401 PMC11889932__F2 This diagram illustrates the interconnected pathways involved in ferroptosis 55240 8031 2182 10162 2937 246 2879 9817 PMC11889932__F3 Regulation of ferroptosis by JAK/STAT signaling pathways, focusing on the roles of different STAT proteins, including STAT1, STAT3, and STAT6, in modulating ferroptosis through pathways like SLC7A11 and GPX4 (Amino acid metabolism) 3627 3717 3716 6772 6774 619501 8651 6778 4170 8678 84447 2833 2937 2879 23657 10552 PMC11889932__F4 Regulation of ferroptosis through the interaction of iron metabolism and the STAT3/NRF2 pathway 9817 3717 196 6774 8031 11054 2512 23657 2879 55240 PMC11889932__F5 Interaction of lipid metabolism pathways of ferroptosis with STAT proteins in human diseases 3717 6772 6774 1374 3659 2182 10162 8788 246 6778 2180 PMC11889932__F6 Ferroptosis and STAT signaling pathways by various compounds in cancer models 619501 2638 6774 6772 6778 2182 10162 2937 246 2879 23787 PMC11889934__F3 Molecular modifications of lactylation in cancer 2539 8408 3939 5159 10524 2033 5187 51441 7157 8567 2861 6774 7422 10371 7412 PMC11889934__F4 Anticancer strategies targeting lactylation 3099 3939 3091 8405 23410 9113 1490 PMC11890030__F1 Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology 6418 3652 5066 PMC11890030__F3 Comprehensive strategies for paclitaxel production: insights from plant cell culture, endophytic microorganisms, and synthetic biology 3652 4602 2077 4609 5066 PMC11890417__F8 The role of LINC01305 and LAD1 in ESCC 3898 2017 285084 1000 999 PMC11890630__F8 Progressive accumulation of transcriptional alterations during the progression of T2D reduces adipocyte thermogenic capacity 59341 10891 4883 4881 4149 5970 23411 10128 9575 5350 79885 406 6096 148523 9759 1149 114548 25842 1375 5728 581 578 3164 1909 56616 5139 8864 55690 6263 6261 845 PMC11891048__F2 S-palmitoylation is involved in immune response types 324 920 3932 5064 27040 5335 2353 131540 8878 948 25921 29801 6774 51304 55625 79844 340481 84885 6850 4067 8772 23390 581 55146 3717 PMC11891113__F3 Expression levels of genes in phenylpropanoid biosynthesis, flavonoid biosynthesis, and galactose metabolism pathways under different drought treatments (CK, D9, D12) in C 1312 790 412 2592 2744 PMC11891403__F6 Exogenous fatty acids inhibit fatty acid synthesis by competing with endogenously generated substrates for phospholipid synthesis in Escherichia coli 8772 95 4018 PMC11892029__F2 BMPR2 and CAV‐1 in PAH 659 3601 5053 51292 4854 387 5879 6876 1499 857 891 4800 PMC11892029__F3 RNA methylation, DNA methylation, and demethylation in PH 9314 5728 56339 10644 1543 54890 9589 10365 400550 51441 91663 91746 9500 54915 2305 1789 1786 7503 9383 6648 2004 659 PMC11892138__F7 Eugenol accelerates intestinal stem cell regeneration to protect the intestinal barrier integrity through inhibiting JAK2/STAT3 signaling pathway in Salmonella enteritidis-challenged broiler chicks 6774 3717 8549 PMC11892258__F3 Mechanism of immunosenescence promoting tumor occurrence and development 3577 6850 54209 10135 23411 PMC11892979__F1 Clinico-genetic Analysis of Adenosine Signaling Pathway in Drug-Resistant Epilepsy 4907 104 132 134 5594 1385 PMC11893431__F2 Molecular mechanism of SATB1 in breast cancer 6304 7291 673 2475 283120 PMC11893456__F8 The main pathological changes in COVID-19 brains and related molecular pathways identified 960 6696 1524 4353 841 64802 6376 100187761 PMC11893557__F2 Impact of autogenous and post-intervention gut microbiota on immune cells in HCC 619501 3627 2475 920 3002 7018 64806 58191 10663 4280 PMC11893596__F2 Pathophysiological actions of MLKL in the lysosome and endosome 11035 197259 581 3146 2919 2920 2475 1508 PMC11893596__F3 MLKL-related pathophysiological events in the endoplasmic reticulum and nucleus 11035 197259 8737 PMC11894105__F2 Molecular mechanisms of apoptosis pathway activation 355 8717 8772 637 581 331 PMC11894105__F3 TNF-induced necroptosis signaling pathway 1540 8772 8717 7186 7188 197259 PMC11894105__F5 Molecular mechanisms and regulatory networks of ferroptosis 7018 2936 55240 2879 2182 10162 PMC11894248__F3 An example of the complexity of p21‐activated kinase (Pak1) signaling in a ventricular cardiac myocyte 6010 998 5058 1356 6722 PMC11894248__F4 Scheme illustrating ON and OFF states of the canonical Hippo signaling pathway 4485 9113 55233 81532 PMC11894577__F8 KEGG website to retrieve a map of the key pathways of CE action in ovarian cancer 2475 1977 6009 7249 2885 7097 7099 5879 6850 613 930 5934 5728 572 6256 4602 4193 PMC11894581__F6 PPI networks 7448 6422 6696 3339 51107 1051 5606 9253 8650 3891 4239 114899 5499 10631 7450 4653 2167 60559 2239 7529 3689 7417 3026 3726 7739 2274 56944 6203 10399 1488 5627 286 6868 4772 28983 PMC11895685__F1 Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma 7124 3565 3596 3558 3567 85480 90865 3578 PMC11896656__F1 Interferon-driven Metabolic Reprogramming and Tumor Microenvironment Remodeling 3428 7098 115004 29110 3661 3665 3454 3455 3459 3460 3716 7297 3717 6772 6773 2475 PMC11896785__F2 Mass Spectrometry as a First-Line Diagnostic Aid for Congenital Disorders of Glycosylation 5236 199857 79868 29880 4351 116150 79947 22845 5373 29926 29925 8813 8818 54344 11253 23443 91869 10195 29929 5589 23193 84920 1650 3703 201595 84061 7991 58505 6748 6747 9382 25839 91949 84342 10466 83548 22796 57511 60684 4247 2530 55343 197258 7264 2683 6487 64116 55858 147007 537 10159 23545 84317 203547 10559 PMC11896877__F2 Activation process of nuclear factor kappa B (NFKB) and the regulation of the NFKB signaling pathway by the small ubiquitin-like modifier (SUMO) 26054 59343 29843 301 7873 PMC11897032__F1 Pathways of serine synthesis and metabolism 6470 6472 26227 4397 875 PMC11897346__F7 Graph model for the role of SR-A3 in protecting against MAFLD through the XIAP/PTEN/AKT axis 331 5728 2475 PMC11897526__F1 Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway 29949 3717 7297 PMC11897528__F2 Lipid metabolism in GBM cells 22937 1956 3949 54898 PMC11897528__F5 Double-edged sword of metabolic reprogramming in GBM, showing the balance between resistance mechanisms and therapeutic vulnerability 3099 19 2194 367 3934 3615 2879 5971 PMC11897911__F6 PGAM5 activating NFKB signaling pathway to promote polarization of M1 macrophages 192111 2475 7124 PMC11898294__F1 T-cell activation, immune suppression, and therapeutic strategies in the TME 941 940 970 939 325 3162 355 PMC11898294__F3 Types and mechanism of nanovaccine adjuvants 115004 7124 3458 4283 PMC11898294__F6 Enhanced CTL responses in TNBC via MUC1 mRNA nanovaccine and anti-CTLA-4 therapy 594857 4582 940 1493 4280 PMC11898294__F7 CD8+ T cell-enhancing nanovaccines for cancer treatment 3661 3665 7124 PMC11898298__F6 Ironomycin cytotoxic effects alone and in combination with other drugs 2879 581 695 613 84433 PMC11898300__F5 Diagram of tumor cell biomechanical perception, conduction, and effect mechanism 2475 6010 759 9780 4397 999 PMC11898721__F11 QSAR-Based Drug Repurposing and RNA-Seq Metabolic Networks Highlight Treatment Opportunities for Hepatocellular Carcinoma Through Pyrimidine Starvation 51727 953 56474 1503 1841 129607 1854 1723 377841 7298 PMC11898953__F9 Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways 10346 3717 6774 2475 PMC11898961__F1 Simplified 5-ALA metabolic pathway 210 10058 2235 PMC11898978__F1 PI3K/AKT signaling pathway is a key regulator of primordial follicle activation 3815 2475 5163 5728 7248 7249 6194 PMC11898978__F2 Tissue fragmentation and mechanical manipulation disrupt the ovarian Hippo signaling pathway, promoting follicle growth 4485 26524 9113 60485 PMC11898993__F8 Molecular mechanism of GNC against IR-induced DOR 602 3880 1509 5447 7018 7054 2099 2100 PMC11899125__F1 Signal Transduction Pathways of Co-inhibitory Immune Checkpoints 940 941 942 634 3902 201633 151888 PMC11899125__F3 Immune-checkpoint signaling 940 941 942 3932 PMC11899125__F6 Primary resistance 3627 4283 1493 3902 567 1956 5728 9760 1499 2475 PMC11899224__F10 Effect of BBR on NLRP3 inflammasome pathway and TLR7/NFKB pathway 114548 79792 4615 51284 3553 PMC11899273__F2 Schematic diagram of LPS clearance: LPS entering the systemic circulation binds to HDL in the blood to form an LPS–HDL complex 7099 4615 3569 3383 7412 PMC11899273__F3 Increased expression of FABP4 in LSECs may represent a potential target for liver injury 2167 3627 2833 PMC11899589__F7 Schematic representation illustrating the mechanism of action of erianin in lung cancer 2475 790 1723 PMC11899595__F1 Key molecular mechanisms/rationales for targeted agents in mantle cell lymphoma (MCL) 51185 7852 6387 2475 22806 10320 581 596 695 3492 973 4067 6850 PMC11899777__F4 Comprehensive Review of Fc Gamma Receptors and Their Role in Systemic Lupus Erythematosus 6850 6714 695 6010 2002 PMC11899827__F1 IL-17 signaling pathway in the pathophysiology of spondyloarthritis 51752 149233 84818 7124 PMC11899831__F3 Mechanotransduction in tumor cells: sensing and transducing mechanical signals from the ECM into intracellular biochemical signals 999 5879 55920 6714 387 26524 9113 9411 9448 PMC11899857__F7 NFATc1 plays a central role in regulating the expression of downstream genes and proteins, including CTSK, MMP9, DCstamp, integrin B3, ATP6v0d2, and ACP5 4772 1513 4318 81501 245972 54 PMC11899884__F1 PI3K/AKT/mTOR pathway in Cancer 5728 64798 7248 7249 PMC11899884__F4 PI3K/AKT/mTOR-mediated autophagy by NPs in cancer therapy 7248 7249 6009 PMC11899901__F4 KEGG pathway map showing the differentially spliced genes within the adrenergic signaling pathway in the heart 6324 6262 5350 3371 2778 112 7169 4633 775 781 PMC11900433__F5 NRF2–ARE pathway 9978 8452 9817 PMC11900433__F9 Phosphoinositide 3-kinase (PI3K)/Akt pathway 5728 5163 2475 PMC11900433__F11 Unfolded protein response (UPR) pathway 7494 7186 468 22926 PMC11900819__S4 Proposed organization and role of adenosine receptors in mitochondria 145258 84890 7416 PMC11900823__F7 Mechanism of BRD7 inhibiting immune escape of NPC 29117 6774 2475 PMC11900955__F1 Different immune cells by TBK1 29110 115004 3661 6352 PMC11900955__F2 TBK1 in key mechanisms of inflammation-associated diseases 4397 619501 29110 PMC11900975__F2 Multiple mechanisms of T-cell exhaustion induced by neutrophils in the TME 969 10135 4914 249 6774 PMC11900999__F2 This figure shows a schematic diagram of the molecular mechanism of neutrophil suicidal NETosis 2597 1019 1021 4353 79792 PMC11900999__F3 This figure shows the role of NETs in AS and its related mechanisms 114548 4353 7035 7450 54106 100187761 3172 3008 PMC11901361__F2 Proposed FRAlpha-mediated endocytosis and signaling pathways in cells 6774 999 2821 7157 PMC11901387__F1 Effect of the microbiota on drug resistance in HCC 3716 2309 114548 196 7099 1956 2475 6774 PMC11901428__F1 Host-microbiota interactome in IBD 8213 2859 196 1903 53637 8698 9294 1901 7100 PMC11901933__F8 Reparative potential of LF in UVB-exposed HaCaT cells 3037 3373 4312 4087 4088 4092 PMC11902984__F1 Pro-apoptotic TRAIL signaling pathway 8772 637 581 317 331 PMC11903262__F2 Protective role of Trem2 in different models of myocardial injury 54209 6850 4280 3586 PMC11903573__F3 KATs and HDACs play a role in glucose tolerance and insulin resistance 8841 9759 10013 23411 51548 79885 7536 7099 3667 2308 8660 PMC11904106__F1 Targeting intracellular autophagic process for the treatment of post‐stroke ischemia/reperfusion injury 1950 5163 7248 7249 6009 PMC11904505__F3 Endometrial carcinoma (EC) cells strategically employ immune checkpoint pathways, with a notable focus on the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis 8205 3845 920 PMC11904754__F5 The GALNT14 protein regulates the occurrence and development of lung cancer 79623 4092 637 4088 4087 4089 1499 324 5099 3918 PMC11904754__F6 GALNT proteins involved in lung cancer and pathway related 2589 2590 2591 114805 11226 8693 PMC11904867__F2 Nur77 in glucose metabolism 8544 2203 2027 5315 5224 2023 2475 PMC11905258__F6 Potential therapeutic role of MSCs and EVs in treating CKD 3082 911 9242 999 4314 7076 4087 4088 4318 7124 3383 6347 5111 6352 PMC11906358__F4 Molecular model of light-induced signalling pathways for clock phase shifting 23373 1020 8864 5187 2669 150094 1846 3725 2353 PMC11906358__F5 Balancing dopamine levels by clock components 8864 1407 7054 4128 PMC11906670__F3 S1P synthesis and influence on cDC migration 1903 53637 8698 9294 1901 8877 56848 1236 6366 6363 PMC11906670__F4 Biosynthesis and role of 7A,25-OHC in cDC localization within secondary lymphoid organs 9023 9420 10563 643 1236 6366 6363 920 PMC11906677__F7 Mechanism of PP suppressing NLRP3 inflammasome by targeting CK1A–Beta-catenin–NFKB–NRF2–mitochondrial OXPHOS pathways during bacterial infection 1499 79792 114548 PMC11906681__F2 Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation 6469 5727 2735 2736 6608 51684 2737 PMC11906681__F3 Targeted therapy in pediatric central nervous system tumors: a review from the National Pediatric Cancer Foundation 3479 3480 7248 51256 6009 7249 2475 PMC11907527__F3 Additional analysis on Amini et al, J Neuroinflammation, 2023 (PMID: 36691064) 65065 9110 23143 3082 9644 3221 8540 84284 2869 10544 54796 3609 23075 9781 7482 1021 8745 5781 5139 3091 1655 23165 5588 5295 8573 10000 5583 23516 84707 5775 55770 1803 79879 56477 2113 5533 2841 27334 1901 1493 3590 4088 2625 2475 2744 57634 28659 285282 6146 6504 4522 84524 51561 7188 9397 29121 2053 89894 11044 4753 152926 23345 57546 55422 10225 5198 125488 7745 140883 PMC11907527__F6 Subgroup-specific heterogeneity in common pathways 2688 1950 7292 650 8600 7124 4803 959 7039 4049 958 4055 608 114609 51567 4615 7188 7189 7186 7187 7535 3654 5336 7128 7335 23118 257397 84433 6885 4214 841 10454 1147 29775 8915 8945 3551 5970 4791 3066 3065 81537 54210 3459 4907 1241 29851 3554 5265 374 2064 2182 5166 1604 3934 27306 1378 3949 1843 3082 5873 2119 3340 240 5657 4317 4318 1991 51738 3606 2353 3557 5008 944 PMC11907553__F1 The KRAS signaling pathway 3845 572 2475 29110 998 PMC11907837__F1 Wnt/Beta-catenin signaling pathway 4041 4040 324 1499 PMC11907837__F2 Wnt/Beta-catenin-related ncRNAs that regulate tumour cell proliferation, metastasis and invasion 140828 100422991 9218 23476 100302208 387111 324 1499 724027 2146 494333 285735 84791 100126313 57216 100302179 5326 139628 406961 23492 84973 PMC11907956__F4 Structure and PTMs of PD-L1 (phosphorylation, glycosylation and ubiquitination): Presented here is a schematic diagram that illustrates the functional domains of PD-L1 as well as its diverse PTMs 4751 2931 1950 2932 3716 10331 1019 8405 6737 54918 25820 4734 54941 144423 55611 7874 9101 8239 27005 23326 PMC11907956__F5 PTMs of CD47: When CD47 on the surface of tumor cells interacts with SIRPA on macrophages, it causes the intracellular portion of SIRPA to be phosphorylated 140885 961 6737 PMC11907956__F8 PTMs of TIGIT: TIGIT binds to CD112, CD113, and CD155 324 201633 2885 7189 PMC11907960__F2 Key effector cells in radiation-induced lung injury 4087 4088 387 2475 PMC11907984__F2 Main function of CBXs family proteins 10873 8535 23466 84733 7703 10951 6839 PMC11907984__F3 Details of CBX members regulate Wnt/Beta-catenin, Hippo, MARK signalling pathways in tumours and mechanism 2638 10951 619501 11335 84733 8535 57332 8091 64151 1499 2263 5142 595 3845 23492 1786 1788 126374 57016 652 PMC11907984__F4 Details of CBX members regulate PI3K/AKT/mTOR, NFKB signalling pathways in tumours and mechanism 84733 5704 5290 5293 2475 146850 1956 5091 57332 23492 7316 2261 3667 595 2146 619501 6280 79102 5728 PMC11907984__F5 Details of CBX members regulate TGFB, Notch, HFI-1, P53/P21, E2F1/BIRC5, Rho GTPase, PRDM1/c-FOS signalling pathways in tumours and mechanism 8091 11335 5091 23492 8535 11091 3690 7040 51129 7422 64750 7046 406928 595 7431 23468 1956 57332 619501 1869 4904 3838 65268 7316 83478 5879 4313 639 6010 PMC11908050__F1 Glioblastoma signaling pathways 2475 1977 6009 2885 6850 613 5879 930 5728 5934 572 4199 4602 PMC11908107__F8 LXR-alpha agonist is involved in various biological functions in liver transplants 2475 7124 367 PMC11908393__F8 Tenascin-C induces microglial polarization through the TLR4/MyD88/NFKB pathway 3371 7099 4615 PMC11908617__F4 Effect of ZNFs on CRC metastasis‐related pathways [46, 47, 51, 52, 55] 346171 23528 92822 55713 10794 171017 1499 284695 PMC11909752__F8 The proposed mechanism for chronic adrenergic stimulation induced heart failure via cAMP-PKA-PDE4D signaling pathway and protective mechanism of PDE4D inhibition 5144 23411 65018 PMC11909974__F10 Integrative analysis of transcriptome and metabolome reveal molecular mechanism of tolerance to salt stress in rice 4118 100188011 9365 PMC11910004__F7 Epimedium brevicornum Maxim alleviates diabetes osteoporosis by regulating AGE-RAGE signaling pathway 4087 4089 183 6401 3383 7412 7056 4313 7018 2308 836 581 6774 3717 6772 5292 4772 1019 1958 PMC11910855__F8 Schematic diagram illustrates the impact of targeted activation of ErbB4 receptor on hippocampal neuronal damage, neuroinflammation, and cognitive functions in mice exposed to PS-MPs 2066 6857 7099 23410 6855 1795 114548 PMC11911240__F1 CGAS-STING-TBK1 signaling pathway 115004 3661 5971 5970 29110 PMC11911240__F4 Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy 115004 5064 10419 3276 5763 3661 8520 29110 1650 10475 23650 10107 PMC11911305__F2 Simplified unscaled representation of MD‐2/TLR4 complex signaling induced by extracellular LPS 3929 929 7187 29110 3665 7099 114609 4615 51135 3656 7189 10454 PMC11911377__F1 CGAS-STING signaling pathway and its role in innate immunity 3661 3455 3454 6773 6772 29110 3627 7124 PMC11911377__F5 HBV evasion and activation of the cGAS-STING pathway 8520 115004 3838 PMC11911380__F2 Inflammatory crosstalk and anti-inflammatory mechanisms in the angiotensin II-induced fibrosis pathway 7124 5879 4117 PMC11912584__F1 HRS-4642 can inhibit KRAS G12D binding to SOS or RAF1 and inhibit downstream MEK-ERK signaling pathways KRAS: Kirsten rat sarcoma viral oncogene homologue SOS: Guanine nucleotide exchange factors (GEFs, e 1950 3845 7074 29110 998 572 2475 PMC11913433__F8 M6A modification-mediated MTHFD2 upregulation drives tumor-promoting effects via the PEBP1-RAF1/MEK/ERK signaling cascade 56339 10644 10797 5037 PMC11913671__F2 Inflammatory pathways in glomerular disease 6774 6775 6772 5771 5781 3383 3903 114548 10013 PMC11913674__F1 mRNA vaccines immunogenicity 324 920 613 7098 23586 57506 51284 51311 4615 29110 6041 3665 3661 PMC11913683__F2 Mechanisms by which CAT promotes osteoblast differentiation 7474 7481 847 6469 4513 7124 6608 5727 6283 2735 5310 23411 2932 4086 4093 4090 4089 650 860 3479 2475 PMC11913683__F3 CAT inhibition of osteoclast differentiation 5728 51548 4772 581 1513 100187907 126014 PMC11913683__F4 CAT has anti-osteoporotic effects through other pathways 5310 23411 2932 860 3458 2879 1543 4513 596 3717 6774 PMC11913833__F10 Regulation network by ACS on the innate and adaptive immune systems of young rabbits 7097 7099 64127 10392 114548 324 920 PMC11913853__F12 Differentially expressed genes implicated as top candidates for mediating the effect of selective breeding on behavior are often regulators of bioenergetic function 7351 90550 387787 51599 9798 6687 10939 4967 56964 PMC11913854__F7 DHP-mediated apoptosis in HCT116 cells 355 8772 7454 637 100188784 PMC11914309__F7 Differentially expressed genes in Chemokine Signaling Pathway (rno04062) using transcriptomic data at 168 h after TMT administration 2885 3845 1399 5908 5604 572 PMC11914309__F9 Differentially expressed genes in TNF Signaling Pathway (rno04668) using transcriptomic data at 168 h after TMT administration 8717 1147 1540 8772 3725 PMC11914587__F10 TGFB signaling 7046 7048 4087 PMC11914587__F11 Interactions between astrocytes, microglia and neurons leading to neuroinflammation 3553 6647 114548 929 7097 PMC11914587__F14 Mitophagy in neurons 23410 6774 9140 PMC11914587__F3 Interactome of the molecular systems architecture of the NMJ microenvironment involved in ALS pathogenesis 23098 6010 2521 10371 29978 203228 PMC11914587__F7 Autophagy in neuronal death 8878 203228 55255 140775 10133 29110 PMC11914797__F2 BBR and its derivatives influence the mechanism of apoptosis 581 331 637 PMC11914797__F5 BBR and its derivatives are involved in autophagy mechanisms 2475 22863 64798 64223 8408 115004 7942 960 65018 PMC11915041__F4 Research progress on the role of decorin in the development of oral mucosal carcinogenesis 1634 3480 7078 7422 PMC11915071__F3 Biological roles and molecular mechanism of circular RNAs in epithelial-mesenchymal transition of gastrointestinal malignancies 80005 6774 4087 4088 4089 5019 693167 57817 324 2932 1499 6935 2521 1003 102 PMC11915076__F1 Oncogenic and tumor-suppressive roles of Lipocalin 2 (LCN2) in tumor progression 468 3934 3569 1901 3570 6774 PMC11915795__F9 Proposed model for SVV antagonizes type I IFN signaling by targeting HDAC4 9759 3661 4938 PMC11915864__F9 RNF20 demonstrates dual regulation of the chicken MDA5-IFNB signaling pathway by targeting chMDA5 (created using Figdraw) 57506 29110 56254 3665 PMC11917101__F11 Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/Beta-catenin/TCF4 signaling in sepsis-associated encephalopathy 4353 7473 1499 1003 6925 PMC11917137__F7 Schematic model for the mechanism and role of HOGA1 in ccRCC 112817 1499 595 PMC11918095__F7 SiO influences fibrosis in HTMCs via ferroptosis induction 2879 23657 50507 4088 PMC11918467__F6 H2 can protect H9c2 cells from H/R injury by inhibiting the Wnt/CX3CR1 signaling pathway 7099 1524 3146 847 324 1499 PMC11918971__F7 Aerobic exercise (AE) stimulates the synthesis of anti-inflammatory “muscle factors” such as IL-6, IL-10, and IL-1ra through skeletal muscle contraction while reducing the activity of proinflammatory factors such as TNFA 7124 627 1392 3479 PMC11919857__F5 LncRNA-NEAT1 in cancer 4117 283131 6662 23213 3159 1786 3845 PMC11920683__F10 Schematic showing genes upregulated by ibudilast treatment during NMDA retinal damage on scRNA‐seq analysis 3479 2885 3667 7248 5163 64798 64223 6010 2475 9675 253260 23678 6446 51256 6009 1977 8408 2887 PMC11921546__F2 LPS-TLR4 mediated signal transduction pathway 3929 929 7099 6850 4615 3654 51135 3656 7189 10454 64374 7187 10010 29110 54822 PMC11921618__F9 Schematic model illustrating the mechanism of TMEM176B inhibiting OC progression 28959 1499 595 PMC11921692__F1 USPs and NFKB signaling pathway 4615 8717 3654 51135 8737 7189 7186 7375 1540 23118 10869 11274 9100 7187 8237 29761 7874 9958 5971 PMC11921692__F2 USPs and TGFB signaling pathway 8239 7375 4092 7189 9618 1540 57154 4087 4088 83844 9958 64750 4089 9100 8237 PMC11921692__F3 USPs and Nrf2 signaling pathway 9101 8975 7874 9958 10600 29761 9817 8452 9978 8237 57663 PMC11921692__F4 USPs and p53 signaling pathway 7874 9100 1540 8239 8237 10713 159195 7375 4193 3091 23326 55131 100187761 57602 PMC11921819__F1 Molecular mechanisms and crosstalk among five cell death modalities: Apoptosis, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis 7124 8772 7186 317 114548 10162 2879 55876 1737 11019 81030 2242 PMC11921819__F4 Ferroptosis in Tumor Immunity 6520 23657 2879 948 920 PMC11921819__F5 Cuproptosis in Tumor Immunity 3146 115004 920 3002 3454 6772 6774 84171 942 6347 PMC11922625__F2 Interaction of tau and DRN 3550 1018 5550 1020 PMC11922731__F8 This graphic illustrating the role of the CXCL2/CXCR2/Jun signaling pathway in microglia-neuron crosstalk in SAE 2920 3579 7037 5743 3725 PMC11922768__F8 The molecular architecture of plaque-associated axonal spheroids 23208 6844 9145 160 6855 6857 3916 2548 5476 10670 3920 1509 64121 6616 1191 535 27072 64601 4905 8775 55737 79065 1213 10533 10313 6252 821 203068 7846 7314 5708 7317 5707 5577 351 55605 1778 7874 824 2023 3301 23193 3303 5702 372 4137 23385 2475 8874 6543 6262 348 2893 3069 6009 87 2891 718 30849 815 3074 55004 10094 5530 207 10787 492 10396 4628 491 51761 6711 490 3708 4915 801 9908 2562 PMC11922887__F1 Potential mechanisms of HDAC1 and HDAC2 in microglial activation and/or neuropathic pain 6667 3066 3371 7099 3065 4615 8841 PMC11922887__F2 Potential mechanisms of HDAC3 in microglial activation and/or neuropathic pain 23411 120892 8841 6772 54790 9447 115004 PMC11922887__F3 Potential mechanisms of Sirt1 in microglial activation and/or neuropathic pain 114548 23411 23237 6469 2735 3146 7099 4615 PMC11922957__F3 Multiple Pathways of Draconis Resina Treating MIRI 3146 7472 1687 581 1499 PMC11922957__F5 Mechanisms of the Draconis Resina on Cardiovascular Diseases 5340 6774 5743 3383 7412 5300 4087 4088 4089 PMC11923325__F2 Structure and mechanism of TLR4, highlighting both MyD88-dependent and MyD88-independent pathways 4615 7099 3661 PMC11923325__F3 Involvement of TIR domain-containing adaptors in TLR signaling pathways 51284 7100 54106 10333 7096 114609 4615 3654 7189 7097 929 7099 7098 PMC11923325__F5 Downregulation of TLR signaling 8651 7189 3654 6761 59307 51135 929 7099 114609 4615 PMC11923548__F10 Paeonia suffruticosa Andrews root extract ameliorates photoaging via regulating IRS1/PI3K/FOXO pathway 472 3667 2475 1647 847 9817 PMC11923913__F5 Signaling pathways in TRALI 3146 7099 6387 958 7852 9353 54538 2475 PMC11923913__F7 Cellular mechanisms, signaling pathways, and potential therapeutic targets in TRALI 958 54538 7852 3146 PMC11923913__F6 TRALI‐targeting therapies 3140 7099 3146 958 7852 2475 PMC11923990__F9 Zbp1 Mediates central nervous system inflammation induced by AC via promoting macrophage inflammatory phenotypes 3627 4283 920 PMC11927159__F1 SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer 2879 6382 581 317 PMC11927159__F3 SLC7A11 Inhibitors Represent a Promising Therapeutic Target by Facilitating the Induction of Ferroptosis in Breast Cancer 7018 55240 6510 2744 2937 2879 PMC11927577__F3 KEGG signaling pathway analysis of up-DEGs and down-DEGs in AD 1514 2760 1785 55367 10787 1520 1512 5605 9267 2317 PMC11927582__F2 LAT in the TCR pathway enhances signal transduction by sequestering inhibitory factors through a LLPS mechanism 27040 2885 2353 PMC11927582__F3 Sufu plays an important regulatory role in Toll-like receptor (TLR)-mediated inflammatory responses 4615 3654 51135 7189 51684 114548 PMC11928134__F7 HPS1 and ITK function in melanocyte and T-Cell 3257 3702 3558 3569 7124 PMC11928533__F3 Diverse biological functions of the CRIP family 324 1396 8424 10273 1499 355 7874 475 1397 2475 637 595 3458 6374 2919 581 10131 6352 7424 1385 PMC11928765__F2 Epithelial growth factor receptors (TGFBR/EGFR/KGFR) cellular signaling and their regulation by 16E5 1956 1950 7039 3082 2255 2247 4092 4087 64750 4088 2885 10818 54845 80004 7248 7249 6009 6774 4089 PMC11928779__F5 MTOR signaling network 64223 64798 1977 4553 652968 6009 84232 PMC11928779__F10 One carbon (1C) metabolism 1719 4548 4507 4144 262 4397 4524 191 875 9054 867 2937 51380 PMC11928779__F8 A‐KG and tRNA deoxygenation in the cytosol and mitochondria 54888 63899 8846 24140 PMC11929342__F5 Nrf2 as a target in ovary and ovarian dysfunctions focusing on its antioxidant properties 9817 100126333 5052 847 PMC11929655__F1 MTOR signaling pathway 7248 7249 6009 2475 54541 PMC11929655__F3 Protein–Protein Interaction (PPI) Network and Enrichment Analysis 7249 7534 7157 2810 7248 8626 7533 7532 10628 PMC11929932__F2 Immunomodulation on tumor immune microenvironment in acquired targeted therapy resistance and implication for immunotherapy resistance 958 9332 1236 1019 4585 9611 94025 PMC11930081__F8 Proposed signaling pathway activated by oxidative stress in NHEKs 7295 10628 1956 10970 2305 5163 22943 PMC11930217__F1 Key signal transduction processes of TGFB and Notch signaling pathways in renal cells 4851 4089 4088 3280 595 4193 PMC11930265__F9 LTA promotes aerobic glycolysis (AG) and M1 polarization in macrophages by activating the NFKB signaling pathway 3099 3091 572 4049 PMC11930710__F2 Model illustrates how resistance to EGFR-targeted drugs develops due to the loss of PTEN expression, caused by impaired nuclear translocation of EGR1 in lung cancer cells: A 1956 1958 5728 PMC11931041__F2 Diagram of the PI3K/AKT/mTOR (PAM) signaling pathway 80762 5728 5163 5164 253260 9817 7249 7248 64223 64798 PMC11931045__F2 Red rectangles for upregulation, the blue rectangle for downregulation 100271873 100506229 2475 3383 643911 PMC11931053__F8 Huoshan Dendrobium Zengye Jiedu Formula mitigates radiation-induced oral mucositis and improves oral immune microenvironment by targeting the EGFR/PI3K/AKT pathway: evidence from network pharmacology, molecular docking, and experimental validation 1950 1956 581 PMC11931058__F8 Distribution of key targets in the most relevant pathways 6722 4149 2316 7124 8717 7186 2645 355 1616 4208 929 23118 51701 1950 183 6401 4313 7054 7018 5300 6774 3717 1019 1958 PMC11931165__F8 Osteogenic differentiation of GLP-1RA on BMSCs 4041 1499 324 860 121340 PMC11931784__F8 Heatmap of DEGs involved in the JA synthesis pathway 4015 3055 4609 PMC11931864__F6 Molecular mechanisms through which hUC-MSC-sec improves aged oocyte quality 9242 627 1618 54766 PMC11932036__F1 Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review 4851 4855 4853 4854 100188776 PMC11932658__F1 n-6 and n-3 HUFA biosynthetic pathway 9415 60481 3992 54898 745 7808 PMC11932845__F1 FGF/FGFR signalling pathway in mammary epithelium and TNBC 3535 100187907 2886 PMC11932863__F6 Targeting cell cycle arrest in breast cancer by phytochemicals from Caryto urens L. fruit ethyl acetate fraction: in silico and in vitro validation 546 1663 114799 157570 9126 25836 5885 23383 10274 10735 23063 983 151648 4087 4089 4193 6502 9319 57082 699 9184 991 5111 1017 1022 90381 27085 4661 8318 923 81620 10926 324 8555 PMC11932893__F2 Molecular mechanisms of AMPK-regulated lipid metabolism 2194 8408 355 10628 7942 PMC11932893__F3 Regulatory mechanisms of AMPK in MASH-associated inflammatory response 23411 10014 96459 56947 8408 3553 4087 4088 2475 6648 PMC11933022__F4 TMAO effect on CKD: Three main pathways are depicted: TMAO activates macrophages by stimulating NLRP3 (NOD-like receptor protein 3) and stimulates T cell differentiation to produce multiple inflammatory factors, such as TNFA, IL-6, etc 114548 4088 4089 2475 7124 1401 PMC11933059__F2 PAM pathway mechanism of action 5728 1019 1021 PMC11933101__F1 Pyruvate synthesis pathway 367 7498 7504 PMC11934544__F7 Protective mechanism of EA on IVDD 1998 4131 4130 4133 358 360 PMC11934714__F2 The roles of retrotransposons in adult neurogenesis 3065 6657 1499 4204 4916 6664 91746 80312 9 79670 PMC11934714__F4 HERV in schizophrenia 1813 27185 109729128 115004 3661 207 2879 6520 7474 7222 627 1814 PMC11935715__F7 Piezo1 promotes atherosclerotic endothelial inflammation in response to OSS 3383 7412 9780 6714 PMC11936079__F3 Involvement of EMR2 in Wnt/Beta-catenin signaling pathway 1107 155465 2300 1655 10630 4763 PMC11936485__F8 Mechanism and signaling pathways of the inhibitory effects of HST on the proliferation of LUSC cells 4851 891 83939 983 581 836 PMC11936551__F2 LncRNA-MALAT1 acting as ceRNAs and its involvement in the EMT process of retinopathy and regulating the corresponding signaling pathway factors 378938 699 10643 29028 1003 6774 55014 5148 6295 7422 2978 10533 1499 3383 PMC11936574__F1 Interleukin-18 signaling pathway and its functional binding with IL-18 receptor 114548 4615 7189 3654 51135 10068 7124 PMC11936945__F1 TRAIL-DR5 related cell death regulation signaling pathway (Das et al 197259 54822 11035 56169 79792 114548 7124 7186 841 637 9049 581 545 472 836 840 6774 842 317 596 PMC11936992__F3 AMPK regulates the mechanism of action of FNIP1 780896 10133 7942 201163 96459 7249 6009 PMC11936992__F5 Interaction of FNIP1 with autophagy 96459 57644 6938 4656 6355 PMC11936992__F6 Action of FNIP1 in causing cancer 201163 57600 96459 7248 7249 6009 6010 1956 7030 6773 7942 PMC11937136__F6 Proposed mechanism for reproductive damage induced by ICIs through testicular inflammation, oxidative stress, and ferroptosis, as well as the protective role of RSV against ICIs-induced reproductive toxicity 1728 847 9817 23657 6520 2879 2182 4513 PMC11937194__F4 Related mechanisms of TRPV3, TRPV4, and Orai1 in tumor angiogenesis 59341 162514 84876 PMC11937194__F5 Related mechanisms of TRPC1, TRPM7, CLCA2, CLCA4, and TTYH3 in the process of EMT 54822 7220 22802 80727 5894 1000 PMC11937194__F6 Related mechanisms of TRPV1, TRPM8, Orai1and KCa3 7442 79054 84876 969 7124 PMC11937194__F7 Related mechanisms of TRPC3, TRPV1, L-VGCC, A2D1 and TTYH3 in regulating tumor stemness 7222 7442 80727 3265 595 4313 PMC11937447__F2 Functions and mechanisms of lncRNAs in endoderm differentiation 100507428 10664 101410536 2128 3170 2627 64321 145258 79923 3192 2020 2019 3198 847 7855 10644 PMC11937519__F4 Schematic overview of the proposed BDNF-TrkB-FRS3 signaling pathway, its role in energy balance regulation, and its connection to the leptin-melanocortin pathway 3953 181 5443 4160 5122 4280 627 10817 PMC11938626__F2 HBsAg induces the HCC tumorigenesis by promoting proliferation 5894 6714 2932 324 1499 595 619501 PMC11938626__F3 Various oncogenic effects induced by the ER stress in the development and progression of HBV-related HCC 6461 3972 2475 22926 7186 7494 6720 47 468 2181 9415 7422 9965 6774 3717 PMC11938626__F6 Oncogenic mechanisms of HBsAg mutants in hepatocarcinogenesis 6461 3972 619511 7422 1019 1017 2475 619501 PMC11938631__F3 Multifaceted roles of TGFB signaling in BBB integrity 4087 4088 4089 7046 7048 PMC11938631__F5 Activation of the Wnt/Beta-catenin signaling pathway maintains the BBB integrity 84879 857 1499 324 PMC11938631__F6 Mechanisms of Shh signaling pathway in maintaining BBB integrity 6469 2735 6608 5727 PMC11938631__F8 Major common pathways regulating BBB integrity after TBI and in AD 4035 2475 4318 6608 6469 2735 5727 857 84879 PMC11938789__F7 The role of ZBTB6 in BC proliferation 10773 395 6774 PMC11939404__F9 Proposed mechanism of action of GAD037 3643 91653 81 PMC11939858__F1 Influence of RANKL, sclerostin, and DKK1 on glucose metabolism and the corresponding signaling cascade 4041 4040 22943 1803 2919 324 1499 7187 2475 PMC11939868__F2 Long non-coding RNAs (lncRNAs) regulate immune escape in the tumor immune microenvironment (TME) 283131 5820 6774 149775 100422829 378938 10230 652995 102800310 PMC11939868__F3 LncRNA and Tils in TNBC 60674 100859930 4633 920 100616320 114915 100507436 4277 PMC11939912__F2 Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders 627 126669 2885 2549 572 6010 PMC11939912__F3 ProBDNF/p75NTR reverses the effects of BDNF/TrkB signaling, which activates the mTOR pathway to control actin remodeling and spine protein production, hence weakening dendritic spines [115] 2475 627 2059 387 1975 1977 PMC11940265__F5 Oocyte meiosis signaling pathway, with genes detected in ovary and testis transcriptomes 3630 3479 5447 4342 1017 914 4661 699 5347 717 9985 10734 9126 PMC11940265__F6 Arachidonic acid metabolism pathway, with genes detected in ovary and testis transcriptomes 4057 4050 4049 239 5225 5228 PMC11940282__F4 Hepcidin regulation in hepatocytes 7099 6774 654 8452 9817 650 151176 7036 3077 406906 4092 4091 4086 4090 4089 3725 57817 PMC11940432__F2 Intracellular signaling pathways of LGR4 55366 84133 4041 4040 324 1499 5308 PMC11940455__F5 Signaling pathway activated by EGFR and TRKB receptors resulting in cell proliferation 1956 1950 627 3845 2885 2475 PMC11940482__F5 Calcium signaling pathway with RMPs 90550 5350 857 858 759 859 3270 7942 10345 613 5266 PMC11941040__F3 Acute inflammation and molecular pathways induced by red complex bacteria and Fusobacterium nucleatum in endothelial cells 4975 929 7096 7097 7099 4615 1003 3383 7412 19 PMC11941073__F1 GOLPH3 regulates the spatial distribution of glycosyltransferases within the Golgi cisternae 64083 2475 6480 PMC11941171__F11 Mechanism of action of SJB2-043 in A549 cells 2475 7398 1499 PMC11941256__F1 BMP signaling pathway 655 653 650 652 654 6010 PMC11941340__F1 Interaction of the WNT pathway, Hippo pathway, and Notch pathway 4485 80014 55841 23286 26524 9113 4151 4041 4040 8312 2932 324 1499 7004 8463 7005 7003 PMC11941373__F7 Impact of DNA damage pathways on improving anticancer efficiency and reducing systemic drug resistance 472 672 5888 PMC11941543__F2 Influenza virus interaction with autophagy 8678 3320 2475 PMC11941683__F1 Summary of healing stages following a bone fracture 4089 4086 4090 4091 9242 7939 1499 324 860 PMC11941885__F2 Immune-mediated podocyte injury 920 941 942 1604 718 114609 4615 3661 3665 2271 PMC11941885__F3 Mechanical stress-related podocyte injury 7224 7225 998 5879 387 8542 23529 57669 PMC11941992__F2 Three main signal transduction pathways associated with GPR120/FFAR4 stimulation: —ANTI-INFLAMMATORY EFFECTS via beta-arrestin 2 (ARRB2) signaling in immune pro-inflammatory cells 355 7099 10454 114548 2695 920 PMC11941992__F3 The mechanisms by which visceral obesity is a triggering factor for both systemic inflammation and insulin resistance (IR) 324 7099 114548 325 920 23452 3630 3643 2475 PMC11942496__F3 Function of the MAPK Signaling Pathway in Cardiac Hypertrophy 655 5606 2475 PMC11942534__F3 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism 4485 60485 55233 9113 PMC11942534__F4 5-Methylcytosine Methylation-Linked Hippo Pathway Molecular Interactions Regulate Lipid Metabolism 4485 60485 55233 9113 355 1788 PMC11942745__F3 Putative schematic representation of the mTOR signaling pathway in APS 7248 7249 6009 64223 64798 PMC11943269__F4 Schematic model represents the possible RT role in adjuvant therapy for TNBC 10663 22949 1956 1723 6774 2475 7272 PMC11943624__F3 Key metabolic pathway components and targets for nanomedicine-based targeting (rectangles represent components, rounded rectangles represent enzymes, and dashed lines and multiple arrows indicate omitted multistep reactions) 29881 3939 790 1719 1723 948 355 3156 3614 3615 2618 471 PMC11943704__F5 Plasma Proteomics and Metabolomics of Aromatase Inhibitors-Related Musculoskeletal Syndrome in Early Breast Cancer Patients 1956 126669 3858 3861 596 9166 1509 3880 7031 5241 7018 PMC11943880__F1 Kynurenine pathway 125061 8942 8564 23498 130013 23475 PMC11943880__F2 Physiological effects of KYN pathway metabolites 2859 196 115004 29110 3661 8614 1045 4583 PMC11944037__F11 Biomarker-pathway-target network diagram of IPE anti-RA 7167 683 387 3934 4860 5599 5743 6714 207 1432 1890 4846 213 1719 3320 5602 PMC11944057__F2 Crosstalk between the PI3K/AKT/mTOR pathway and the MAPK pathway 3667 5728 5163 2475 PMC11944911__F6 D-LA biosynthetic pathway in engineered S 2819 2820 51660 PMC11945191__F1 The host type I interferon signaling pathway by bacteria 115004 57506 64127 10392 7099 7098 51284 54106 51311 7187 4615 29110 7189 PMC11945442__F11 Proposed mechanism by which ACA affects the TNF-Alpha-induced NFKB pathway and ICAM-1 expression 8717 8737 7186 3383 PMC11945619__F6 Principal component analysis (PCA) of growth and development indices and related genes in the liver tissue of Rana zhenhaiensis tadpoles after exposure to polypropylene (PP) and polystyrene (PS) 59330 4846 8647 43 7001 5313 6389 2879 10935 6390 11315 2597 5743 3455 3551 121457 84649 80221 5467 3295 2167 54954 47 6342 338 55289 32 7917 55334 29108 223082 840 663 64798 5296 56658 836 PMC11945810__F1 Possible mechanism underlying hepatotoxicity 1431 5053 7124 PMC11945810__F2 Illustration of cell crosstalk and molecular pathways of different chemicals in the liver microenvironment 5053 942 196 PMC11945976__F4 Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact 2539 6120 7498 7504 PMC11946485__F1 PI3K signaling pathway inhibition and antitumor immune synergistic therapy strategy 50943 6774 325 7054 PMC11946485__F2 Regulatory role of PI3K signaling pathway in immune cell function 581 613 8320 604 6774 920 572 PMC11946485__F5 Development of PI3K inhibitors represents a promising strategy to enhance the efficacy of cancer vaccines through the modulation of immune responses 324 942 941 940 613 3565 1236 PMC11946680__F7 Action induced by 3-MCPD 11035 197259 8737 PMC11946830__F2 Hijacking cellular pathways and oncogenic mechanisms in Cryptosporidium infections: Cryptosporidium manipulates several key host cell signaling pathways to ensure its survival and potentially contribute to cancer development 7097 7099 2875 998 324 8826 5970 PMC11946974__F1 Bitter Taste Signaling Pathway 29850 255022 119395 PMC11947053__F2 Research progress and prospect of MAPK signaling pathway in knee osteoarthritis 7124 7186 7189 5879 5008 3725 2114 2002 2353 4609 PMC11947373__F1 COVID-19-induced molecular mechanisms that propel OSCC development and chemoresistance 59272 8829 114548 2475 8678 PMC11947922__F1 Novel mechanism targeting Beta-arrestin-2 for the management of diabetic nephropathy 22926 468 7494 PMC11948033__F3 Modulation effect of TEVs on CD8+ T cell 648 3135 8473 3383 84890 355 PMC11948033__F4 Treatment strategies to reversing immune escape 9101 4072 84890 PMC11948861__F3 Autophagy-mediated ferroptosis 23657 9474 55054 8031 79065 10533 7942 2475 2879 8887 5641 1152 23558 468 10299 3091 30061 3241 1000 1719 PMC11948861__F4 Autophagy-mediated other forms of RCD 2475 3146 811 324 920 7405 693222 9140 9474 23001 83734 10533 142 1508 PMC11948946__F8 Analysis of gene expression related to hormone signaling pathways 51411 404685 2077 1879 64641 PMC11949690__F6 Findings—hypothalamic IGF1 signaling can be dynamically regulated 3479 3488 3480 3643 3667 8660 406 2308 181 4852 5443 9607 80763 51083 PMC11950169__F6 Key mechanisms involved in TTFields-induced activation of AKT 387 1000 572 PMC11950302__F8 Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer 4691 581 637 5163 PMC11950527__F3 Annotated map of EM on PCa-related signaling pathways 2322 920 8453 51426 8772 7187 23118 7186 29761 6364 6354 6347 3934 6278 4314 4322 100187907 7054 PMC11951404__F1 Transcriptional and posttranslational regulation of CONSTANS (CO) CO acts as the core regulator of the photoperiod response pathway to integrate external and internal signals into the photoperiodic flowering pathway 878 64326 1408 PMC11952772__F2 Lactobacillus regulate skeletal muscle pathways through short-chain fatty acids 3479 2475 2867 2865 PMC11952802__F4 Periosteal microenvironment on P-SSCs 860 4803 6424 10631 4345 PMC11953055__F8 Schematic illustration summarizing the mechanism by which NSUN2 promotes colorectal cancer (CRC) 6774 54888 8450 1956 PMC11953061__F3 Protein–protein interaction (PPI) networks of reproducible and differentially expressed proteins (RDEPs) were generated via the STRING database 999 54205 581 7157 142 6857 1026 5468 595 5562 5777 5747 2475 6648 7846 5970 4313 7852 5111 7431 PMC11953409__F1 Metabolic pathway shifts in T cells 324 7248 7249 6009 PMC11953509__F7 NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/Beta-catenin signaling pathway in colorectal cancer 324 1499 4751 595 PMC11953522__F2 String pathway analysis of the significant genes with k means clustering → Red: apoptosis network (Bcl-2 family protein complex), yellow: Aspartyl transferase activity, Green: S100 protein pathway (1 6280 6279 6283 90427 10603 867 23624 2885 868 8739 598 93978 10018 4170 599 638 5366 637 PMC11953571__F3 Exercise activates the EGFR/insulin signaling 351 847 759 57381 5596 PMC11953998__F22 Design strategies for nanodrugs targeting the mitochondria and lysosomes 2191 51596 4827 594857 PMC11953998__F24 Synthesis process for the polymer DBD and the formation of NP-DBD nanoparticles 4827 29110 115004 PMC11953998__F5 Schematic illustrations showing different nano-targeting systems achieving precise mitochondrial localization and killing tumor cells through mtDNA perturbation (a–b) and metabolism disruption (c–d) 115004 7019 3661 29110 PMC11954216__F1 Cellular Mechanisms of mTOR in BCSCs: This schematic illustrates the multifaceted roles of mTOR in regulating cellular functions in BCSCs, with implications in metastasis, metabolism, autophagy, and ferroptosis 7416 10013 5879 387 2475 6662 8408 PMC11954216__F2 The mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials 3273 3479 3480 10544 6489 2014 7249 6657 4087 4088 4092 64750 960 PMC11954216__F3 Targeting the PI3K/Akt/mTOR Pathway in BCSCs with synthetic drugs: This figure depicts synthetic inhibitors targeting the PI3K/Akt/mTOR pathway in BCSCs to reduce survival, proliferation, and resistance 2475 1956 4851 PMC11954216__F5 Naturally occurring products that inhibit mTOR in BCSCs 2475 5728 718 10873 PMC11954244__F2 Isoflavone biosynthetic pathway 5539 3398 3652 5805 PMC11954783__F2 Review of recent molecular pathology of bladder urothelial carcinoma 84133 54894 1499 324 4041 4040 55366 8549 59352 PMC11955304__F3 STAT3 Signaling Pathway in Health and Disease 6774 3569 3589 9021 6714 10401 PMC11955602__F0 Diagram illustrates how herbal formulations and extracts derived from TCM exert potential effects on AD through modulation of the PI3K/AKT signaling pathway 572 581 5728 5163 PMC11955613__F4 Ferroptotic osteocytes promote osteoclastogenesis 6520 23657 2182 10162 2879 PMC11955613__F5 Pyroptotic osteocytes promote osteoclastogenesis 114548 834 79792 837 838 PMC11955616__F2 The cGAS-STING Signaling Pathway in Lung Cancer Immunotherapy (By figdraw) 115004 54790 83850 9572 27239 7465 29110 54984 25939 3661 PMC11955616__F3 Function and Regulatory Mechanisms of the TLR Signaling Pathway in Lung Cancer (By figdraw) 7096 7097 10333 7100 7099 81793 4615 7098 3661 3665 51284 54106 51311 PMC11955616__F4 Function and Regulatory Mechanisms of the RIG-I Signaling Pathway in Lung Cancer (By figdraw) 57506 29110 3661 3665 PMC11955630__F9 Pathway analysis for CKS1B and related genes 6098 5979 2066 3815 2322 1956 4915 2261 2260 3480 2263 2064 238 4914 5156 6654 867 54206 4893 3845 253260 5781 5728 5879 3265 6016 4763 5921 369 673 5605 5894 5604 10000 208 207 7248 4193 6794 7249 1029 7157 6009 57521 6197 472 11200 PMC11955793__F5 Anti-inflammatory and antioxidant effects of hUCB-MNCs 3569 7124 3558 3596 3586 9817 PMC11955793__F6 hUCB-MNCs inhibit fibrosis process 999 1000 4087 572 PMC11956203__F4 Key mechanisms of neuro-cancer crosstalk in HNC 3569 2571 2717 8811 4318 4313 9429 4513 4316 7852 3717 6275 4322 PMC11956211__F6 Apoptosis signaling pathway in KEGG 7018 759 1616 8772 790 835 9825 7124 472 1540 2752 5836 27005 4015 5008 197259 100 3014 637 114548 90865 PMC11956214__F8 Cell cycle signaling and key proteins 546 4199 5111 1537 1017 100187761 4118 PMC11956240__F8 Interaction analysis of the differentially expressed proteins and metabolites involved in the top 10 enrichment pathways 80150 32 1373 2628 5106 435 6296 790 10873 4200 2746 162417 27165 79814 8647 2875 84706 5091 383 5009 1576 2806 18 1544 7363 5315 8659 54600 847 1080 10864 10599 1610 6470 6822 2639 51166 8564 1559 1558 54658 29920 7915 217 501 54659 1571 224 125061 223 316 PMC11956425__F5 CXCR3/PLC/IP3/IP3R signaling pathway stimulated by PT 1080 2833 2717 3458 PMC11956735__F2 Platelet factor 4 (PF4) regulates several immune cells 5196 7046 920 2833 3558 3596 6352 6850 54106 5132 51284 324 51311 3569 PMC11956896__F1 Mechanism by which PCSK9 regulates lipid metabolism 3949 948 255738 PMC11956896__F3 The regulatory effects of PCSK9 in T cells and tumor cells 255738 3949 4772 7099 7054 PMC11957794__F3 Different types of COL remodeling-mediated signaling pathways 6774 780 11319 9817 6374 PMC11958682__F2 Rewired amino acid metabolism and FA metabolism in HCC 151258 81539 2746 2747 2805 2806 84706 440 80150 1373 5009 445 383 26227 29968 5723 6470 355 948 8140 2180 586 587 790 435 47 PMC11958682__F3 Rewired acetyl-CoA metabolism and redox homeostasis in HCC 81539 2744 2937 PMC11958781__F9 Mechanistic diagram illustrates that KLF6 cooperates with FOSL2 to promote H3K23su levels and enhance 5-FU resistance in HCT15-FR cells 1499 10629 10512 2355 5879 PMC11958968__F3 Network representation of DSF, its modulated targets, and pathways involved in RF 2475 5580 7066 1571 3356 240 5159 6104 8737 94005 3717 5743 5728 114548 1026 7124 9966 1512 2512 2309 3028 4318 217 3757 5295 5320 PMC11958968__F5 Cluster analysis for DSF-modulated targets 1576 4313 7077 1728 6647 3696 217 4318 7412 4257 7124 7852 1571 1230 240 5742 1380 2990 1236 PMC11958968__F11 DSF against renal fibrosis via inhibition of PIK3/Akt/mTOR signaling pathway 4089 4088 2475 5728 5163 1000 999 PMC11959002__F1 ncRNAs inhibit PCa metastasis through the PAM signaling pathway 8450 55353 5728 55366 9846 7764 2064 2065 4751 5066 PMC11959002__F2 ncRNAs promote PCa metastasis through the PAM signaling pathway 541471 100505875 8450 990 100616146 100302166 6364 57291 8420 5101 100506190 100302217 5728 78998 1956 105376843 2146 255082 5066 PMC11959002__F3 ncRNAs promote PCa growth through the PAM signaling pathway 100616146 57291 1956 100302166 5728 728192 6364 105376843 2146 5066 PMC11959002__F4 ncRNAs inhibit PCa growth through the PAM signaling pathway 493812 8450 57498 2020 9314 55366 60674 5728 5066 PMC11959002__F5 ncRNAs regulate PCa angiogenesis through the PAM signaling pathway 57498 253260 2475 5066 PMC11959002__F6 ncRNAs regulate PCa tumor stemness through the PAM signaling pathway 79923 1956 648 2260 9314 3480 6657 5066 PMC11959038__F7 Association of LRP1B with the Hedgehog signaling pathway in CRC 6469 53353 5727 8643 6608 51684 11200 2735 1869 595 891 983 1017 2737 2736 PMC11959054__F7 Role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout 8651 9021 3717 4615 6774 6772 PMC11959080__F2 Subcellular localization and proposed molecular mechanisms of ZNFX1 114548 57169 57506 PMC11959089__F1 Overview Diagram of Ferroptosis Mechanism in Mycobacterium tuberculosis, EB Virus, and SARS-CoV-2 Infections 23657 2879 5524 5743 PMC11959147__F1 Illustration of the PI3K (left) and TP53, inside the nucleus, (right) signaling pathways [21, 22] 5728 3479 64798 472 545 11200 4193 581 PMC11959162__F3 Ubiquitination in bone homeostasis and osteoporosis 11060 4734 6502 57154 51444 9100 860 10413 7874 2263 4086 4090 4041 4040 4087 4088 55611 83844 54532 1499 64750 79791 PMC11959162__F2 Phosphorylation in signaling pathways involved in osteoblast differentiation 4041 4040 6608 4086 4090 4093 1499 51684 4089 6662 860 PMC11960544__F3 Exploration of the signaling pathway of extracellular matrix (ECM)-receptor interaction in stem cells from human exfoliated deciduous teeth-conditioned medium (SHED-CM) 960 7450 255743 1101 1758 56955 948 1832 961 PMC11960914__F9 Schematic diagram of PHB1 and PHB2 expression in blood vessel wall cells and the possible molecular pathways in terms of adhesion of ECs and proliferation, migration, and autophagy of VSMCs 3383 7412 595 2475 4318 PMC11961428__F2 Transcriptional regulation of HIF induced by hypoxia, adapted from (3) 7428 665 2056 PMC11961548__F7 Construction of miRNA-gene regulatory networks in rat fatty liver associated PNF cases 23476 51386 6873 6874 6884 PMC11963613__F1 This figure illustrates the role of the APC gene within the Wnt signaling pathway and its significance as a cancer biomarker 4041 4040 1499 324 PMC11963613__F3 This figure illustrates the toxicity and management strategies associated with Wnt-directed therapies in cancer treatment 1499 324 55364 PMC11963613__F4 This schematic illustrates the role of Wnt/Beta-catenin signaling in tumor immune evasion and potential therapeutic strategies targeting this pathway 324 1499 3902 201633 961 151888 PMC11964413__F7 Proposed mechanism suggests that ABCG8 upregulation in RT-R-MDA-MB-231 cells mediates cholesterol efflux, leading to increased cancer cell progression through the LRP6/Wnt/Beta-catenin signaling pathway in RT-R-MDA-MB-231 cells 4040 1499 5347 2194 64241 PMC11964643__F2 Effector-mediated inflammation 201292 998 5058 7189 58484 6774 81844 PMC11964952__F2 Proposed chart of T1D dual vulnerability initiated by Beta-cell metabolic dysfunction and CD4+ T-cell activation 942 847 324 941 940 920 2695 169792 10628 1512 7297 7494 83939 467 79792 PMC11964952__F3 T1D targets for therapeutic interventions in endocrine cells 1956 3651 4825 1839 6750 3630 217 572 894 1019 10628 114548 2642 2641 170302 1786 2696 PMC11964952__F4 T1D targets for therapeutic interventions in immune cells 324 942 930 920 914 6775 7124 941 367 1803 940 84890 1390 3662 50615 10628 3486 969 3458 3479 389692 124446 PMC11965140__F3 Immune activation and immune imbalance induced by CORT 1325 920 114548 3553 2475 51744 6362 6361 6367 472 11277 3428 90865 PMC11965140__F5 Immune activity by CORT through TREM2 3586 54209 1325 5336 4615 3717 6774 114548 8651 9021 PMC11965140__F6 Multiple pathways mediate the inflammatory injury of CORT induced cell death 1325 28514 558 7099 8651 9021 4609 7942 10461 2621 5627 54567 114548 79792 7494 22926 80204 604 PMC11965322__F1 STRING PPI analyses 6414 7040 2811 3480 7078 6868 3791 3549 2879 84168 627 2324 285 6671 5789 2321 7423 10381 6910 3162 1071 154 3075 55829 6609 23554 185 8322 4693 4041 9201 2034 3091 10247 1803 6387 8874 4846 9069 7099 8899 183 1636 3553 3586 7124 2056 PMC11965601__F1 LBP in inhibiting retinal cell apoptosis 3929 2475 3553 PMC11965601__F6 Autophagy regulation in Lycium barbarum L 3929 7249 8408 9706 5163 PMC11965705__F1 Important pathways and their functions in pancreatic ductal adenocarcinoma 1956 1950 2475 2885 5728 1499 PMC11966298__F1 CGAS-STING pathway 115004 3661 7124 3627 4283 PMC11966298__F4 Applications of metal-based nanomaterials in tumor immunotherapy 115004 29110 3661 PMC11966486__F1 CD28 signaling motifs mediate co-stimulatory signaling to regulate T cell function 324 942 941 940 7409 2885 3702 3932 3558 PMC11967072__F5 miRNA-mRNA regulatory network analysis and screening of the hub miRNAs 7157 6777 6935 55294 3480 1958 1147 5925 960 6667 5578 894 5594 598 627 23411 2932 2033 1385 5599 2308 2247 6720 2475 949 5728 2309 1021 6009 7249 3667 6850 613 930 5934 572 4193 PMC11967251__F7 Mechanism graphic in this study 6714 6774 10643 7424 999 PMC11967982__F13 C-type lectin receptor signaling pathway (Pathway ID: hsa04625) from KEGG pathways 4046 6850 114548 10487 868 387 100187761 7054 602 10129 7216 6347 6361 4193 PMC11968285__F7 SONFH reveals that BMSC Piezo1 in response to elevated IOP regulates bone vascular homeostasis through CAM-NFAT1 signaling pathway 9780 6387 860 PMC11968292__F3 Keap1-dependent and Keap1-independent regulatory pathways of Nrf2 8452 9817 196 857 PMC11968360__F1 Organoid models of ovarian cancer from three different sources 3099 675 3418 3939 6773 221937 3694 7350 PMC11968765__F2 Signal transduction mechanism of SWELL1 in different tissues and cells 857 2885 2308 3725 596 1017 595 581 4904 54888 PMC11968978__F1 Canonical Wnt pathway signaling 7551 54894 4041 4040 1499 324 8658 4609 1956 6657 PMC11968978__F2 Non-canonical Wnt pathway signaling encompasses two major branches: the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway 4920 4919 6259 23002 387 51701 1386 PMC11968978__F3 Overview diagram of Hedgehog pathway, Notch pathway and TGFB pathway 6469 3549 50846 51684 6608 54567 28514 10683 3714 182 3280 388585 23462 26508 4087 4088 4089 PMC11968978__F4 Crosstalk between Wnt and FGF signaling pathways 10818 2885 2549 1499 PMC11968978__F5 Wnt signaling pathway in cancer stem cells (CSCs) 4920 4919 6259 7551 54894 4041 4040 5376 10131 960 4038 3202 2146 8549 1499 340419 596 PMC11968978__F6 Wnt signaling pathway plays a crucial role in modulating the immune microenvironment of tumors 3620 4041 4040 3484 6351 50943 PMC11968978__F8 Wnt signaling pathway in various cancers, including colorectal cancer, hepatocellular carcinoma, lung cancers, chronic myeloid leukemia, triple-negative breast cancer, melanoma, and glioblastoma multiforme 324 2932 619501 1499 3172 81847 7976 23002 1857 5879 9687 10401 387 3052 1386 613 7543 595 4286 4041 2475 23554 PMC11969464__F2 Ingenuity pathway analysis of differentially enriched proteins 5649 6844 100170220 6616 627 348 26059 1398 5340 572 23122 2475 4082 5923 8831 2889 1500 4301 7094 5894 673 1432 1742 10160 1020 1072 PMC11969464__F3 Visualization analysis of pathways identified from normalized, significantly differentially-SUMO-enriched proteins 2931 55750 3954 84446 5879 88 375 26059 2915 2043 11346 8927 5781 9066 273 115827 4134 7818 6009 57142 9456 8661 27335 PMC11969919__F4 Transcriptome profiles of blastocysts originating from oocytes matured in follicular fluid from preovulatory follicles of greater or lesser maturity 288 408 8313 1629 8323 3087 9371 51274 4257 27253 144165 6641 440104 79183 324 1499 595 PMC11970819__F1 Pathophysiology and emerging therapeutic targets of IBD 5724 864 401237 50615 11033 324 149233 920 PMC11972266__F2 Isorhamnetin inhibits cholangiocarcinoma proliferation and metastasis via PI3K/AKT signaling pathway 10682 7249 1977 6497 6850 613 930 373073 1537 951 5934 5728 572 6256 4602 PMC11972380__F8 Schematic diagram deciphering the mechanisms by which ROBO1, G3BP2 and eIF3A form hetero-complex to mediate radio-resistance in ESCC cells 6091 8661 9908 2475 PMC11972507__F6 ceRNA Network of m6A-modified circRNAs in OSA-induced Cardiac Injury 3340 7461 30815 8772 92558 126433 8874 201562 50813 122618 79017 124222 283450 9766 6843 64837 79802 79939 222068 8061 150383 59343 23621 57171 5990 10498 84364 114625 1666 8566 7434 PMC11972515__F2 LncRNAs in acute myeloid leukemia 55000 652995 406987 442892 100506311 283120 145200 1788 55384 3480 104472848 101154753 8205 7503 PMC11973335__F1 MPC mesengenic and angiogenic differentiation pathways are mutually exclusive 54567 717 9242 PMC11973847__F3 PRR signaling pathways associated with autoinflammatory diseases 8737 114548 58484 57506 115004 3661 PMC11974029__F1 Mechanisms through which berberine treats breast cancer involve modulation of the XRCC1 enzyme in BER 4968 7515 5111 2237 PMC11974029__F2 Mechanisms by which capsaicin treat NSCLC involve modulation of the ERCC1 enzyme in the NER pathway 7508 1642 1643 7442 2067 5111 PMC11974029__F3 Apigenin holds promise in the treatment of ischemic stroke by modulating RAD51 and BRCA1 during HRR as well as Ku70/80 in NHEJ 5888 672 2475 PMC11974029__F5 Retigeric acid B effectively treats prostate cancer by modulating the MSH2 and MSH6 enzymes involved in MMR 4292 4436 2956 9156 7518 5888 472 672 PMC11974557__F1 Adipose Tissue Inflammation and Insulin Resistance Mediated by TLR4 Activation and Adipokines 1401 3667 8660 PMC11975384__F1 Comprehensive examination of the Wnt/Beta-catenin signaling pathway 4041 4040 324 2932 1499 PMC11975626__F3 Symbiotic relationship between cancer‐associated fibroblasts (CAFs) and prostate cancer (PCa) 6510 23411 2475 47 PMC11975626__F2 Interactions between immune cells and cancer‐associated fibroblasts (CAFs) 3579 6374 7097 7099 7852 6387 1540 6774 3717 6347 729230 4313 59 PMC11975626__F4 Exosomes between urinary system tumours and cancer‐associated fibroblasts (CAFs) 144766 54894 3181 8091 100506930 5243 8651 6774 2475 3082 1956 64388 PMC11976366__F6 Quercetin inhibits gefitinib-activated cell death in NSCLC via regulating SHP2/ROS/AMPK/XBP-1/DJ-1 signaling pathway-mediated mitochondrial autophagy 115004 3661 114548 PMC11976435__F1 Wnt/Beta-Catenin signaling pathway 4041 4040 1499 324 22943 PMC11976435__F2 Non-canonical Wnt signaling pathway 23002 23500 387 4041 4040 51701 PMC11976707__F2 Key molecular alterations and signaling pathways involved in the pathogenesis and progression of gastric cancer, along with selected targeted therapies (adapted from Lei et al 22943 2263 5728 324 5163 2475 1499 PMC11977057__F6 Mechanism by which phanginin A activated SIK1 to promote glucose uptake in skeletal muscle 150094 10014 9759 51564 3728 4205 PMC11977258__F4 OB-EC communication 7450 652 655 650 7040 5741 860 2246 PMC11977285__F3 Extracellular vesicles (EVs) in mitigating MASLD 2290 3082 283120 383 6774 155 PMC11977922__F1 Signaling mechanism of the canonical cGAS-STING pathway and its downstream effects in diseases 115004 29110 3661 PMC11977922__F2 Mechanisms by which lipid metabolism regulates the STING signalling pathway 10924 115004 22937 8205 PMC11977922__F4 Mechanism through which STING activation leads to insulin resistance 7124 3667 5080 51390 3661 339123 5519 29110 PMC11978054__F11 Impact of hydroxyurea and metformin on Gamma-globin induction involves complex molecular pathways 5594 6667 23764 10642 2623 572 9314 2651 4778 3065 2309 406936 4602 53335 10661 4005 PMC11978054__F5 Visualize interactions between the hub-genes in a co-expression blue module using GeneMAINA 11343 29995 55351 54492 55553 65981 5139 3043 5218 7068 389337 8644 3880 2651 7325 858 10642 6640 221711 389421 10643 9843 3045 100187828 8477 1287 57730 PMC11978139__F2 Molecular processes underlying CXCL2 secretion 7099 355 6774 9021 2920 PMC11978336__F1 Interaction between lipid metabolism and macrophage polarization in atherosclerosis 5091 4018 581 PMC11978336__F3 Interaction between lipid metabolism and macrophage polarization in atherosclerosis 55937 7412 7124 3383 10011 PMC11978336__F5 Interaction between lipid metabolism and macrophage polarization in atherosclerosis 19 9619 114548 7099 3586 PMC11978694__F5 MiRNA in treatment of gout arthritis 7097 8651 114548 2069 10725 9839 4615 10365 7422 7099 PMC11978822__F1 MPDOLs for treating primary lung tumors and brain metastases in NSCLC 7808 1956 10643 PMC11978843__F6 Analysis of DEGs related to energy metabolism, phytohormone synthesis, and signaling pathway 790 2147 2152 2153 4149 PMC11978951__F4 Astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique 1387 3685 4780 6774 5290 5781 6256 7422 7099 2475 7298 31 2247 4313 1019 367 25 5328 2033 4193 1147 4790 1956 1017 207 2645 598 4582 604 1080 6714 5156 3320 5294 1576 3417 208 3688 PMC11978951__F5 Molecular interactions and downstream effects of the HIF-1 signalling pathway 2056 7037 5891 3939 5163 226 PMC11979195__F2 Modulating oxidative stress: a reliable strategy for coping with community-acquired pneumonia in older adults 9817 4094 847 PMC11979243__F3 Exosomes from different mesenchymal stem cells mediate apoptosis in brain cells after cerebral ischemia-reperfusion injury 23326 2308 23604 23411 2475 9447 PMC11979251__F2 Immunogenic cell death (ICD) induced by epigenetic modifiers of DNA methyltransferase, histone deacetylase and proteasome inhibitors 8841 301 3627 11334 3146 811 7494 PMC11979251__F6 Crosstalk between immunogenic cell death (ICD) and different intracellular signaling pathways of nuclear factor kappa-B (NFKB), stimulator of interferon genes (STING), and mitogen-activated protein kinase (MAPK) 10892 3146 29110 811 3661 PMC11979264__F7 Mechanisms by which Met inhibits HGHF-induced ferroptosis and DOP 2495 23657 6520 2879 PMC11979393__F1 The apoptosis signaling pathway 637 581 8772 8717 7186 596 PMC11979612__F12 Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway 664 4976 9474 PMC11980037__F3 KEGG disease pathways map analysis displays downregulated DEGs influenced by DEX-induced M2c macrophages involved in anti-allograft rejection 941 942 940 324 3002 7124 958 920 3458 PMC11980100__F9 Histone acetyltransferase CBP participates in regulating the DNA damage response through ATM after double-strand breaks 3014 472 4361 10111 PMC11982459__F3 Hormonal regulation of the UPR by ABA, JA, and SA 5640 4881 2597 PMC11983172__F11 Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study 7099 3569 2841 PMC11983301__F2 Podocytes, renal tubular epithelial cells, and glomerular mesangial cells in DKD 324 23327 23650 999 7428 2539 84676 117584 55294 65018 2194 2626 29761 7189 57154 23326 1540 23411 10206 PMC11983340__F1 Engineered metabolic pathway for the biosynthesis of disubstituted MAAs 7086 6886 1537 PMC11983443__F1 Leptin and adiponectin in health and disease 2475 6774 3717 920 7054 PMC11983503__F2 CTNND2 involved in the WNT/Beta-catenin pathway 999 2260 3091 79918 10298 324 1499 PMC11983503__F3 Regulatory mechanisms of D-catenin associated with neural development and function 999 85358 253260 324 PMC11983633__F6 Ribosomal protein L9 is a potential therapeutic target for B-ALL through the activation of the p53 signaling pathway 6133 79068 100507436 4277 PMC11983764__F1 BCAA metabolism and tumours 55890 586 9673 587 10295 152926 PMC11983764__F2 BCAA hypocatabolism promotes tumour development 586 2146 57559 9673 26001 587 5861 594 593 991 4211 10295 47 PMC11984396__F3 Diagram of cellular immunity mediated by splenic immunocytes 324 920 7054 325 PMC11984396__F6 Molecular mechanisms underlying neuro-immune interactions 7442 79054 8989 7432 2357 6774 PMC11984396__F8 Activation of CAP by electrical cervical nerve stimulation and splenic ultrasound stimulation to combat inflammation 7054 1103 920 3717 PMC11984404__F9 Schematic diagram regarding key parts of this study 4280 3934 3718 6774 1524 PMC11984845__F8 Proposed model integrating multi‐omics data of FIIN‐2 highlights the regulatory network of downstream and involved signaling pathways 1956 10818 7248 7249 2475 6774 7018 4397 55529 598 5054 3383 1969 PMC11985188__F2 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in PI3K/AKT/mTOR signaling pathway in the pathogenesis of esophageal cancer 2475 6278 3608 60674 101805492 6657 1956 PMC11985188__F3 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in Wnt/Beta-catenin signaling pathway in the pathogenesis of esophageal cancer 116113 100124700 101805488 100885775 1499 9839 4313 7422 3383 PMC11985188__F4 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in p53 signaling pathway in the pathogenesis of esophageal cancer 1017 100423038 5728 9589 400500 10898 51441 4193 PMC11985188__F7 Regulatory function of oncogenic and tumor suppressor long non-coding RNAs in MiR-Axis signaling pathway in the pathogenesis of esophageal cancer 7422 5728 100859930 5090 PMC11985419__F9 ICAM-1-Mac-1 mediated NET formation mechanism in response to LPS or LTA 4049 7099 7097 3383 11113 PMC11985624__F1 Osteocytic changes in sclerostin expression mediate bone mechanotransduction to skeletal loading 9242 1499 2932 324 7939 PMC11985624__F2 Conceptual representation of potential mechanisms for osteogenic effects of exercise 55364 3569 50964 9242 PMC11985700__F1 Key signalling pathways involved in muscle atrophy and hypertrophy 100653365 5978 4087 4088 3479 6009 7249 7248 2475 PMC11986138__F1 Expression changes of genes associated with protein processing in the endoplasmic reticulum by the correction of LRRK2 by BAC DNA 6396 5091 258010 55824 100187907 545 100506742 22926 468 9978 PMC11986939__F3 PPI network vs 3815 387569 6714 7372 1956 2099 5467 3558 5894 3643 3717 PMC11987241__F8 M2Φ-exos-mediated TGFB1-induced phenotypic transformation in BEAS-2B cells 4087 4088 4089 4092 PMC11987372__F2 Expression and mechanism of action of chemokine family members in PNI 6347 2920 6280 6279 6374 6387 6354 7494 2919 729230 7852 3579 2475 114548 4615 3976 1524 5728 2596 7097 7099 7098 467 10563 84911 9869 3065 PMC11987792__F3 Exosome-mediated DOX resistance in BC 406947 26994 5295 4851 5728 PMC11987792__F5 Exosome-mediated platinum drug resistance in breast cancer 283871 114548 5728 79184 54478 9024 100616250 PMC11988131__F3 Dual function of PHLDA3 as both an apoptosis inducer and inhibitor 23612 2876 140809 7494 PMC11988162__F1 Illustration of the MAPK (left) and JAK/STAT (right) signaling pathways 6010 998 5788 3725 4609 1386 PMC11988641__F1 MMP13 orchestrates dynamic remodelling of the extracellular matrix (ECM)’s physical properties 4322 8205 4015 4318 1956 999 PMC11988686__F2 Perilla frutescens terpene synthesis pathway; (B,C) P 3156 4598 4597 3652 6420 PMC11988865__F6 Regulatory mechanisms of Brandt’s vole brain tissue in response to hypoxia 2821 7167 5230 3065 9314 5728 207 572 PMC11988921__F1 Unfolded protein response (UPR) signaling pathway consists of three major branches: activating transcription factor 6 (ATF6), inositol-requiring enzyme-1A (IRE1A), and PKR-like ER kinase (PERK) 7186 7494 22926 468 PMC11989024__F3 Cellular signalings and mechanisms of integrin-mediated drug resistance in cancer cells 1956 2475 6714 PMC11989106__F1 MTOR signaling pathway: The mTOR signaling network consists of two branches, each mediated by a specific complex, mTORC1 and mTORC2 1977 23367 7248 7249 64798 5728 6009 PMC11989151__F9 Canonical MC1R signaling pathway 6256 4157 6714 PMC11989323__F2 Biosynthetic pathway of NAPE and NAE 117245 63874 51573 27163 2166 PMC11989355__F4 KEGG pathway diagram 7054 5447 759 PMC11989373__F2 AMPK signaling pathway in brown adipocyte thermogenesis 148 7350 7019 PMC11989508__F1 ER is a membranous network structure in eukaryotic cells, divided into the RER and the SER 22926 83939 468 107966124 PMC11989508__F3 In PD, the molecular mechanism of ERS involves the interaction of multiple factors 83939 284069 7057 120892 PMC11989508__F4 In PD, ERS forms a complex vicious cycle with mitochondrial dysfunction, oxidative stress, and neuroinflammation, collectively driving disease progression 581 120892 7099 3146 PMC11989623__F1 Complexity of the molecular pathways governing the function of the cyclin-dependent kinases (CDKs) through the cell-division cycle 1019 1017 983 4609 1021 PMC11989623__F2 Main mechanisms of resistance to ET and/or CDK4/6is in advanced ER+/HER2− breast cancer 5728 1956 2475 5925 1019 1021 6790 26524 9113 4089 5373 7018 9759 4763 1588 400500 1301 1017 7157 675 672 472 545 11200 PMC11989906__F4 Adipose Tissue Metabolism in Naturally Grazing Sheep at Different Growth Stages: Insights from mRNA and miRNA Profiles 10645 31 2194 6517 5209 6319 5214 PMC11990295__F5 Anthocyanin in modulating PI3K/Akt/FOXO pathway in obesity 5163 2308 2645 PMC11992302__F2 Six signaling pathways associated with the PD-L1 and PD-1 pathways in melanoma 5728 2475 2737 2736 PMC11992733__F6 Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway 7001 6667 2335 PMC11992794__F5 Analyze the DEGs within metabolic pathways 2821 2597 7358 2585 2582 2592 PMC11992894__F9 General schematic view of enzymatic browning (EB) in apple pulp and proposed pectin-related signaling pathway 2077 847 4602 PMC11993586__F1 Lipid synthesis pathways and associated proteins in this review 100996949 5131 3422 84706 1040 11161 84249 5004 5005 983 5091 1442 PMC11993743__F9 The potential of the SA8-E6-12 antibody cocktail to modulate immune responses activated by S100A8 367 7099 4615 6279 581 PMC11993841__F6 Influence of porous metal materials on osteogenesis 1499 860 4969 PMC11993959__F2 Signalling pathways that regulate osteoblastogenesis 5727 6608 860 PMC11993993__F2 LPS proinflammatory signaling pathway 3929 929 114609 4118 4615 3654 51135 7189 7187 3661 3569 3553 7124 6347 PMC11994588__F3 Liquid-Liquid Phase Separation (LLPS) in Cellular Signal Transduction Pathways 2475 8312 324 PMC11994599__F7 Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges 4087 4088 4092 4089 4313 4318 4093 4090 4086 PMC11994677__F1 Crosstalk between KTRM and renal cellular networks 6774 4615 1437 7124 6279 6280 PMC11994733__F1 Suitable concentrations of brassinolide application enhances growth performance and saikosaponin biosynthesis by transcriptional activation of triterpenoid pathway genes in Bupleurum chinense DC 4598 4597 3652 8213 PMC11994733__F6 Expression of key genes in the saikosaponin biosynthesis pathway in B 3930 3652 8213 680 PMC11995091__F2 Sketch represents the impact of nano-encapsulated tea polyphenols impact poultry health 2879 847 2876 7099 4615 PMC11995161__F2 Role and regulatory mechanism of LAPTM4B in tumors 1956 55353 9474 4734 7942 29986 51755 6009 PMC11995514__F2 Core mechanism of apoptosis and related kinases affect the signaling pathway 637 1956 581 6774 2475 PMC11995514__F3 Core mechanism of pyrotosis and related kinases affect the signaling pathway 147945 114548 22861 8717 3002 1687 56169 79792 1956 3001 55876 6774 3717 PMC11995514__F4 Core mechanism of autophagy and related kinases affect the signaling pathway 660 5347 11040 6850 83734 10533 64422 8408 9776 60673 9140 9474 6774 1956 PMC11995514__F5 Core mechanism of necroptosis and related kinases affect the signaling pathway 3466 8772 8717 7186 8737 81030 11035 197259 PMC11995514__F6 Core mechanism of ferroptosis and related kinases affect the signaling pathway 8031 30061 84883 4921 2264 23410 6714 1499 6925 23657 8678 2879 PMC11995686__F3 NFZ signaling pathway diagram 6774 596 993 2078 100616234 27005 8205 PMC11996656__F1 Classical, non-classical, and other pathways involved in pyroptosis 114548 1687 79792 3553 PMC11996656__F2 Pyroptosis in OA pathogenesis 114548 79792 3146 PMC11996656__F3 Signaling pathways involved in the pathophysiological development of OA, along with their corresponding targeted therapeutic drugs 284207 4087 6772 3146 79792 114548 2475 406938 64506 7099 7189 8473 115362 129607 10628 3659 29761 4615 PMC11997178__F2 TRAF2 role in the TNFR1 and TNFR2 signaling pathways 8717 8772 6772 8737 23118 257397 11035 7186 660 PMC11997178__F3 TRAF2 role in the canonical and noncanonical Wnt signaling pathways 6925 23043 1499 4919 7186 PMC11997178__F5 TRAF2 roles in cancer 7186 10487 10486 7474 7855 4919 2475 PMC11997203__F1 PI metabolism and the PI3K/AKT signaling pathway in cell dynamics 200576 5163 4534 90809 4952 8867 5728 56623 253430 3631 5317 PMC11997203__F5 PIPn signaling at the cytoskeleton in the regulation of cell dynamics 4827 998 146057 22897 5177 PMC11997273__F2 The vagus afferent nerve conveying gastric-derived ghrelin signals 23237 4922 2693 PMC11997338__F9 Working model showing a positive role of DSP in the migration and endothelial differentiation of DPSCs through DSPaa34–50–ENGZP association and subsequent activation of AKT1 signaling pathway 2022 1832 207 51129 2321 7060 PMC11997497__F8 Graphic model of dedifferentiation-immunosuppression loop formed by malignant cell and macrophage in ICCMalignant cells and macrophages in ICC are involved in a dedifferentiation-immunosuppression loop 10859 10288 3606 3148 10413 7422 5054 PMC11998019__F3 Exploration of Traditional Chinese Medicine Comprehensive Treatment of Triple Negative Breast Cancer Based on Molecular Pathological Mechanism 3930 1499 3976 2475 PMC11998454__F4 Exosomes secreted by BMSCs, modified with HO-1, deliver miR-124-3p 55240 5728 2879 PMC11998497__F9 PRRSV nsp5 protein interaction that accelerates the ubiquitination and degradation of Nrf2, thereby antagonizing its antiviral activity 9817 3162 5970 3661 1728 2938 4790 3716 7297 10379 PMC11998530__F8 Abortive PDCoV infection triggers Wnt/Beta-catenin pathway activation, enhancing intestinal stem cell self-renewal and promoting chicken resistance 324 1499 8549 PMC11999469__F8 Connection of Nrf2, NFKB, NLRP3 Pathways and the mechanism of SA 9817 8452 9978 7099 834 1728 2730 PMC11999627__F2 IL-33/ST2 signaling pathway 3554 90865 59307 4615 3654 7189 23118 257397 PMC12000012__F3 Divergent regulatory pathways in moderate erythropoiesis and excessive erythrocytosis 2056 2057 355 1460 PMC12000012__F4 Hypoxia-regulated iron homeostasis and erythropoiesis 2056 7018 2057 151176 7036 212 PMC12000012__F5 Pathogenetic cascade of HAPC 5979 355 2056 2623 29843 3569 PMC12000036__F1 TREM2 signaling pathway 2475 54209 6714 79930 945 102 6868 6850 5336 PMC12000036__F2 Functions of TREM2 8027 54209 2475 1499 6714 123 38 19 79930 2885 6654 4615 3717 4087 4088 6772 PMC12000086__F5 Synthesis pathways of 16 esters and alcohols 3064 5132 65057 PMC12000292__F2 ANXA2-induced autophagy inhibits apoptosis in tumour cells 6774 302 7942 6281 8408 PMC12000292__F4 ANXA2 inhibits tumour cell apoptosis and its effects on tumour immunity 8408 302 8772 114548 355 7097 PMC12000394__F0 Molecular mechanisms of HBsAg suppression of the IFNB signaling pathway and triggering of early autophagy 29110 9342 3661 PMC12000830__F2 Regulatory role of MEG3 in cancer progression and suppression 65997 55384 5781 5728 3569 3606 PMC12000830__F3 MEG3 lncRNA: a key regulator of tumor suppression across multiple cancer pathways 55384 5921 581 4318 4313 2475 6774 PMC12000890__F1 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology 7099 7048 7046 4087 4088 4092 4089 PMC12000890__F2 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology 5925 7249 8408 4485 PMC12000890__F3 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology 4615 7189 114548 PMC12000890__F4 Traditional Chinese medicine compounds modulate signaling pathways to improve cardiac-related pathology 9817 23410 847 PMC12001097__F4 Inflammatory cytokines and activation of PI3K/Akt pathway by Yiqi Jiedu Formula in recurrent Herpes Simplex Keratitis: Experimental and network pharmacology evidence 4790 2335 1277 5290 5295 2247 7099 7157 1956 3551 4803 2263 2064 2260 7422 1385 3558 3569 3565 627 596 3791 207 5879 356 1147 5728 672 PMC12001479__F4 Key molecular mechanisms governing mitochondrial dynamics, biogenesis, and mitophagy 7019 2475 55669 9927 4976 65018 10133 PMC12001728__F3 Intricate regulatory mechanisms of programmed death 1 in tumor cells 3466 4193 2475 8011 2530 PMC12001862__F9 Protective function of DHM on renal oxidative stress, inflammation, and mitochondrial-induced apoptosis by regulating the EGFR/HSP27/STAT3 signaling pathway in CP-induced AKI 1956 6774 581 PMC12002712__F1 Biosynthetic pathway of D-tocotrienol in Y 3242 3258 3652 3422 PMC12003104__F2 Relationship between iron metabolism disorder and diabetes and its complications 9973 1356 538 475 540 PMC12003390__F1 Crosstalk between benign non-immune cells and cancer cells 7474 6774 6714 3976 6387 7852 3576 5091 PMC12003521__F2 Mouse LrNK cells in other liver diseases (except for liver viral infection and liver cancer) 115004 90865 7124 3627 2833 920 PMC12003768__F5 Studying the efficacy of JBOL volatile components in idiopathic pulmonary fibrosis (IPF) using GC-MS and network pharmacology 50507 5950 6714 2950 6037 3055 4843 2554 673 9971 4316 5228 3320 6198 1234 5800 54106 1848 5156 6774 5594 2149 5468 3577 5142 1080 240 4317 2638 6532 2147 185 1956 5747 5159 3156 2944 3815 5328 1118 2152 7010 3383 5327 4137 5894 595 1511 3356 207 3558 238 6280 5141 4282 7412 26191 1326 998 2321 729230 4790 1432 3480 4321 4322 4193 5290 1548 650 4842 1991 1559 649 1909 7015 7421 213 3934 2260 5320 1636 2064 5604 5743 6331 836 4312 5739 4780 4318 5243 7276 1889 4314 4638 6401 6469 5340 4353 7153 3717 8654 367 596 7415 5168 427 2324 7225 6868 7498 10381 4311 834 4221 1131 2099 3265 5580 5972 7298 5644 11330 4846 5294 3479 6096 2908 3553 5781 7134 5578 1543 5054 1215 3162 PMC12003952__F1 PLEVPs hydrogel alleviates psoriasis by modulating the IL-17 signaling pathway 920 5132 50943 PMC12003952__F10 PLEVPs deliver pab-miR396a-5p to mediate down-regulation of the IL-17 signaling pathway 3627 3569 3717 6774 6374 PMC12004233__F5 Significant differentially expressed unigenes enriched KEGG pathway analysis by the comparative transcriptomic analysis of Mro-IR knockdown 1588 3949 1601 1950 1956 30846 867 2475 3643 3630 2885 2798 4948 7046 7048 4087 4088 4193 595 PMC12004596__F1 Inhibition of T‐cell activation 324 3932 7535 5728 941 3146 2267 PMC12004712__F10 KEGG “Leukocyte transendothelial migration” pathwayKEGG “Leukocyte transendothelial migration” pathway highlighting the associated AC contrast DEGs 387 5880 998 5879 7006 100124696 399 3676 3683 7852 3689 7070 7408 3684 83700 58494 3688 5624 4267 1003 PMC12004712__F9 KEGG “Cell Adhesion Molecules” pathwayKEGG “Cell Adhesion Molecules (Immune System section)” pathway highlighting the associated a) AC and b) VC contrast DEGs 324 100506658 3684 3689 90952 3683 1003 7054 958 920 4267 6402 11201 947 6403 214 923 6401 10666 8161 5817 5788 914 5800 6693 PMC12004807__F6 Distribution of genes in the TNF signaling pathway 1540 4703 83737 8772 331 3627 717 3976 3600 197259 100187907 PMC12005349__F1 Signalling scheme of the TGFB‐SMAD signalling pathway 7046 4087 4088 4089 4086 4090 PMC12005559__F2 Cholesterol metabolism and transport pathways 3931 3949 4023 PMC12005559__F3 Anchor model of female steroidogenesis, describing the estradiol synthesis pathway, its regulation, and perturbation by dioxin 1583 3283 1586 1588 3292 PMC12006078__F3 Major signaling pathways of acacetin in protecting against endothelial injury and improving atherosclerosis 23411 23410 4088 384 847 PMC12006078__F4 Mechanisms of action by which acacetin prevents cardiac fibrosis and hypertrophy 4088 2475 4092 23411 4089 5465 PMC12006078__F6 Potential mechanisms of acacetin in preventing DCM and drug-induced cardiotoxicity 23411 581 84649 PMC12006087__F4 KEGG pathway analysis 7054 3702 8915 29851 940 2885 7124 1019 PMC12006098__F10 Galangin attenuated MPTP-induced brain tissue injury in PD model mice, and the related mechanism may be related to the PI3K/AKT signaling pathway 2475 7054 627 PMC12006732__F3 Communication between the gut microbiota and other organs 7124 50616 3596 8213 8087 9965 2264 1581 PMC12006828__F11 Biosynthetic gene clusters and (B) the proposed biosynthetic pathways of helvamide B and arizonamides 875 8505 545 PMC12006828__F15 Biosynthetic gene cluster and (B) proposed biosynthetic pathway of stipitatic acid 55720 90121 115939 PMC12006985__F3 An overview of TAG synthesis pathway 4018 2819 4099 PMC12007507__F2 Factors affecting DC maturation and function in NSCLC 7099 6774 4615 64127 6778 6363 PMC12007672__F8 Mechanistic illustration of KGF-2’s role in inhibiting inflammation and alleviating DED by regulating the HMGB1/TLR4 pathway 3146 7099 114548 PMC12008290__F10 Astragalus mongholicus and Hedyotis diffusa willd inhibit cell proliferation by attenuating the miR-582-3p-p27 signaling pathway in LUAD 1017 595 1019 PMC12008652__F5 Cellular and molecular mechanisms revealing the potential effects of magnesium ions on bone repair 650 1385 121340 54822 84061 5879 7189 4772 4041 4040 7099 100187907 1513 PMC12008652__F7 Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals 860 650 4086 5741 54822 PMC12009291__F1 Glucose metabolism and lipid metabolism reprogramming in RCC 5210 55635 1892 95 23417 6737 2203 2146 7388 PMC12009697__F2 Activation of MAPK and PI3K/MTOR signaling pathways by oncogenic FGFR2 fusion protein 10818 2885 2549 4763 5163 5728 7248 7249 6009 PMC12009754__F8 Graphical abstract of the study 2289 4280 100187761 324 1499 PMC12009910__F2 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway 9817 1728 847 PMC12009910__F8 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway 1499 324 4041 4040 85409 PMC12009910__F9 Notch signaling pathway: curcumin can bind Notch-1 protein and the bHLH domain of Hes1 3280 388585 55502 84667 23462 23493 26508 PMC12010877__F8 Growth status of tea plants under drought stress with and without the exogenous application of tea polyphenols 4602 790 1312 PMC12010937__F7 Illustrated summary of the proposed roles of hepatic and intestinal FXR signaling pathways in TPHP-induced bile acid metabolic disorder and MASLD development in mice, based on the findings of this study 7054 1581 8213 PMC12010972__F1 Regulatory mechanisms of the Wnt signaling pathway 4041 4040 1499 324 4920 387 860 3725 PMC12010972__F2 Inhibition of Wnt/Beta-catenin signaling pathway by Wnt signaling pathway inhibitors 50964 22943 11197 4041 860 100187907 PMC12010972__F3 Wnt signaling pathway inhibitors 11197 50964 22943 4041 4040 1499 2932 324 860 PMC12010972__F4 Targeted therapy for osteoporosis 11197 50964 4041 4040 1499 PMC12010983__SF1 Graphical abstract 5196 2921 207 2146 23657 2495 2182 PMC12011584__F1 VEGF signaling pathway in stimulating sngiogenesis (By Figdraw2 7423 5281 7424 8829 8828 PMC12011818__F11 Proposed model of HPV E2-mediated suppression of innate immune signaling 57506 7098 115004 29110 3661 3455 3454 3716 6772 10379 6773 PMC12012199__F7 Targeted demethylation of EphA7 inhibits tumorigenesis via the SP1/DNMT1 & PI3K/AKT axis and improves the response to multiple therapies in cervical cancer 2045 1946 1786 6667 PMC12012437__F1 S100P signaling pathways associated with proliferation, apoptosis, migration, invasion and EMT in tumors 6662 9817 5987 6496 8915 1499 4089 6772 468 6286 10628 PMC12012437__F2 S100P signaling pathways associated with angiogenesis, cell cycle and drug resistance in tumors 7031 999 6286 9404 PMC12012570__F2 CIH modulates glial cells in the CNS through various mechanisms 29843 114548 4615 10043 6098 PMC12012940__F1 Identification and characterization of the core HPARBP network 619501 55621 80745 10171 84271 6629 8562 23560 11325 8607 22916 81608 6188 9669 11338 4869 10915 9129 6637 6741 5901 6626 27316 5725 6632 9898 51067 11052 3609 10657 2130 9521 10137 8087 55833 1778 8655 PMC12012940__F7 The underlying molecular mechanisms of the specific HPARBPs and their common binding targets regulating the Wnt signaling pathway 4041 4040 54894 84133 55366 8549 1499 3609 22916 11338 5725 PMC12012963__F1 Simplified schematic of de novo nucleotide synthesis 7086 790 1723 7372 PMC12013188__F14 Signaling pathways regulating the HAG 7099 10392 4615 114548 1839 6868 7189 1956 4319 3550 9817 581 6774 7124 PMC12013426__F1 Mechanisms of gut microbiome inhibiting the initiation of cancers 58191 6667 8213 7100 7099 7097 1687 3592 1499 581 PMC12013426__F2 Mechanisms of gut microbiome delaying cancer progression 10392 7421 2475 920 6352 84525 4318 7077 7133 PMC12014465__F1 TGFB classical signaling pathway 7048 7046 4089 154075 PMC12014465__F2 TGFB1 signaling pathway plays multiple roles in amelogenesis 265 258 10117 9313 9622 401138 PMC12014580__F1 Cholesterol structure, synthesis, and metabolism 348 3949 3156 4023 4597 2224 6713 4047 PMC12014746__F4 Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats 7099 7423 7422 PMC12014800__F2 Value-added products derived from fatty acids and derivatives, which can be synthesized by yeast cell factories with tuned fatty acid profiles 5064 355 84890 PMC12015243__F6 EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway 2044 6774 595 7076 4609 PMC12015515__F1 Novel signaling pathway linking IL18 proteolytic processing to anticancer immunity 834 836 1024 9636 6772 8809 PMC12015589__F7 Schematic diagram illustrating the beneficial effects of IL-7 during porcine early embryonic development 598 581 6657 79923 PMC12016104__F1 Metabolic pathway of the engineered G 6120 1896 5132 PMC12016271__F10 SFI on podocyte INSR and eNOS proteins in the IR signaling pathway 3643 3667 6420 PMC12016470__F8 Sildenafil promotes osteogenic differentiation of hMSCs and suppresses bone loss by affecting TGFB signaling 4280 4087 4088 4089 PMC12016489__F8 Two major complexes of the mTOR signaling pathway and their pathways 7248 7249 6009 64223 64798 PMC12017852__F4 Relevant signaling pathways of RGS12 in arthritis 81861 6002 7124 PMC12017852__F5 Signaling pathways of RGS12 in tumor 6002 23077 387 5728 3796 2475 3110 PMC12017889__F1 Reported regulatory mechanisms of ferroptosis 55240 2182 10162 23657 2879 4025 8031 2495 2512 2475 PMC12017889__F3 Relationship between ferroptosis and immunity 3458 6772 23657 3146 PMC12018393__F8 Fulvestrant predominant metabolic pathway 54659 54576 54657 6817 PMC12018449__F1 AS-IV in the pathogenesis of arrhythmia 581 9817 114548 2876 4094 7099 PMC12018836__F4 Illustration of eATP signal transduction 84890 11319 7054 4609 4598 PMC12019274__F1 Effect of aberrantly expressed long non-coding RNAs on cell death in different modes 197259 283120 100033819 11035 27161 23657 124905036 2879 79792 23411 114548 1029 PMC12019327__F7 Mechanism of anticancer action of salinomycin and oxaliplatin cotreatment against CRC cells 581 842 836 PMC12020288__F1 Mechanism diagram of RBPs in HCC 6427 22913 23450 6201 3191 2926 10643 23369 8661 4440 65244 6774 56902 51320 339230 5935 5725 54915 619501 1977 2521 26135 57447 3485 56648 27250 1917 PMC12020288__F3 RBPs as potential therapeutic targets for HCC 27316 101669762 55544 9076 9074 60674 6895 2926 7528 619501 54915 3485 196403 PMC12020991__F9 Schematic diagram of the molecular mechanism of PEDV hijacking CD4+ T cells for migration to the intestinal mucosa 8174 5879 998 PMC12021614__F2 Multiple mechanisms of circRNA in tumor immunomodulation and immunotherapy 100313892 4087 4088 4089 PMC12021615__F1 E3s and DUBs in TAK1, ASK1 and mTOR signaling pathway in NAFLD 6885 7187 79651 7375 1540 11274 55611 7189 4217 11074 27332 2475 1655 64798 253260 79594 7248 7249 114548 PMC12021615__F2 E3s and DUBs in SIRT, TGFB, JAK, TLR4 and STING signaling pathway in NAFLD 23411 23326 9100 23327 4089 3717 7099 11342 23321 10498 196528 PMC12021615__F3 E3s and DUBs in NAFLD-related ERS, mitochondrial malfunction, and lipid autophagy 57761 3172 83939 10628 23327 7038 1571 2194 3320 54546 3146 9097 PMC12021615__F4 Other E3s and DUBs in NAFLD 81844 2194 2308 6502 47 9958 5160 38 3297 4193 57602 114548 79611 PMC12021630__F2 Molecular mechanism of PGRN in osteoarthritis 6662 7494 860 3549 4322 7412 650 1311 9140 23411 9474 PMC12021630__F4 Molecular mechanism of PGRN in intervertebral disc degeneration 100187907 8313 860 1499 3553 PMC12021630__F6 Molecular mechanism of PGRN in osteoporosis 468 4280 860 4772 54 1513 126014 100187907 1436 2015 5008 718 PMC12021630__F8 Molecular mechanism of PGRN in DOP 4280 4843 2475 1280 176 3553 PMC12021630__F10 Molecular mechanisms of PGRN in diabetic nephropathy 4280 3099 8408 PMC12021660__F2 Fat-body metabolic pathway profiling 1506 5236 47 5162 PMC12021826__F10 Schematic diagram illustrating how AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway during inflammatory responses 374 6176 7099 1956 4615 79792 PMC12021866__F7 Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation 54567 4851 23411 3280 23462 PMC12021879__F1 Mechanistic map of metabolic bone disease: The pathogenesis of MBD primarily involves four key pathological dimensions: abnormal bone resorption, abnormal bone formation, abnormal mineral deposition, and metabolic factors 5741 4772 8074 4090 4086 4041 4040 PMC12022316__F8 Mechanistic scheme of this study 7481 56339 1856 10643 PMC12022663__F8 Regenerative mechanisms induced by HAps encapsulated in hybrid hydrogels 2247 6275 4627 PMC12022909__F1 AhR-based drug discovery 196 405 847 2152 PMC12023346__F1 Tryptophan metabolic pathway 1644 15 438 125061 8564 8942 23498 23475 PMC12023346__F7 The effects of intraamniotic LPS exposure on the TRP metabolic pathways in the placenta and fetal brain 121278 3620 8564 7166 169355 PMC12023698__F7 Working model of AMPK-ULK1 activating autophagy in nZnO induced bone regeneration 8408 9242 860 121340 PMC12023894__F1 Transmission of the classical Hedgehog (Hh) signaling pathway 3549 6469 50846 374654 5727 6608 51684 2735 2737 2736 8643 PMC12023894__F2 Transmission of the non-classical Hedgehog (Hh) signaling pathway 891 5727 1950 5290 1956 3845 51684 5728 673 2475 572 3549 50846 6469 387 6010 6608 4041 4040 324 7048 7046 4092 4089 1499 2737 51176 4087 4088 PMC12023894__F3 Natural compounds act on breast cancer (BC) through the Hedgehog (Hh) signaling pathway 6469 5727 6608 4851 4854 3280 999 3553 2736 84662 960 100133941 1499 2305 79923 6935 581 595 PMC12023901__F8 ERS-mediated suppression of ERA expression 7494 468 22926 PMC12023943__F4 Keratinocyte differentiation mediated by either CD9 overexpression or calcium stimulation in mouse keratinocytes 928 999 1499 4014 PMC12024087__F9 Bta-Let-7d Modulation of Oxidative Stress Induced by Potassium Permanganate in Bovine Endometrial Cells via IGF1R/PI3K/AKT Signaling Pathway 3480 581 2475 596 PMC12024137__F3 Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review 8660 3667 7124 3651 2308 PMC12024137__F4 Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review 83939 468 1958 PMC12024285__F12 1-DNJ alleviating OS in porcine GCs 5225 581 8011 90550 9927 468 7416 PMC12024365__F8 Diagram of PPAR signaling pathway 2170 2167 51199 9370 5105 345 3158 81616 30 6319 PMC12024444__F1 Hippo signaling pathway regulates cell homeostasis under many factors 26524 9113 4485 5879 5058 6010 60485 860 PMC12024444__F2 YAP/TAZ have different regulatory effects on different stages of osteogenic and chondrogenic differentiation 4599 9242 1277 860 4772 1499 389136 6662 8813 1300 PMC12024444__F3 The Hippo signaling pathway in osteoclasts 7189 4286 9770 4485 60485 84962 26524 9113 4772 860 PMC12024652__F1 Signaling pathway of necroptosis and its PTMs 5763 7124 351 197259 57162 29843 8737 8717 8772 11035 7186 9825 142678 23326 1540 83737 23118 257397 80829 27005 29110 90268 10419 3276 8205 8408 3716 6714 56950 648791 8520 22933 23411 11140 5347 5495 6502 7706 81847 PMC12024679__F2 Notch1 pathway 4851 55294 1840 57801 4609 PMC12024770__F1 STEAP1 protein structure, biological function, and possible carcinogenic regulatory pathway 2308 1977 6774 3717 342538 PMC12025042__F4 Non-genomic actions of Vitamin D 2923 9373 1628 857 7421 6714 4036 8029 120227 6773 6774 6772 821 1591 1583 PMC12025106__F1 Helicobacter pylori infection in methionine metabolism 4397 100188776 4144 PMC12025106__F3 The activated PI3K/Akt/mTOR/c-MYC pathway in metabolic reprogramming to dietary methionine sources 5728 7248 7249 6009 4144 PMC12025219__F3 Changes in bone metabolism caused by cold environment 860 50964 26291 7350 PMC12025273__F6 Mechanism map of cerebral ischemia in JU 4899 7157 1994 7316 2885 7534 6613 2335 3676 3725 PMC12025301__F1 Ferroptosis signaling pathway 1356 2512 8031 2182 55240 10162 2937 246 2879 PMC12025613__F1 Key pathways involved in hepatocellular carcinoma metastasis 2737 2736 2475 324 2689 1499 4091 7046 4087 4088 4485 PMC12025727__F3 Mechanisms by which AEG-1 induces MASH 5465 7186 2194 PMC12025727__F5 Signaling pathways activated by AEG-1 in HCC 3569 5728 6774 1499 1956 4609 1488 51176 324 PMC12026008__F2 Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features 7099 2475 9817 PMC12026011__F1 Pyrimidine synthesis pathway including the two process of pyrimidine nucleotides synthesis: the novo pathway and the salvage pathway 978 4975 790 1723 PMC12026336__F1 RSV infection induces TLR signaling 7097 929 7189 7099 PMC12026460__F3 Comprehensive mechanism by which Irisin influences fibrosis Via Sirtuin 1 (Sirt1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1A)/nuclear respiratory factor 1 (NRF-1), and related pathways 65018 4089 4088 23411 4899 4092 PMC12026832__F3 Signaling pathways in cardiac fibroblast 2475 324 1499 6662 4485 60485 26524 9113 7004 7003 59 6943 6423 57057 983 5111 PMC12027064__F2 The microbiota-induced expression of MMPs during OSCC 375033 4312 3579 2920 PMC12027064__F3 Microbiota-induced expression of MMPs in ECM remodeling during IBD and CRC 4312 3586 7124 920 7099 PMC12027300__F2 Influenza viral suppression of the host immune response by upregulating cellular proteins 3455 3454 163702 3716 7297 3107 3135 3106 3133 8651 51752 57506 9021 6772 6773 861 10397 3661 3665 3065 56848 200424 1956 PMC12027300__F4 Upregulation of cellular proteins that control influenza viral pathogenicity 7099 7852 920 4615 65266 6667 3383 5008 115908 PMC12027374__F2 LH on spermatogenesis, LCs, and sperm cells 1583 9575 1586 1956 3293 367 2492 PMC12027374__F3 LH regulates testosterone synthesis in LCs through multiple pathways 1956 6770 2309 PMC12027412__F4 Component–target–pathway–disease network diagram 367 1499 595 7157 5290 354 PMC12027412__F9 Pathway enrichment analysis and protein–protein interaction among active components and common targets in prostate cancer 5728 2885 5163 6716 367 PMC12027414__F6 Impact of NPC86 on insulin signaling and inflammatory pathways in adipose tissue 1398 23265 23433 10603 867 9322 3628 9021 5602 31 5564 2194 6720 3098 92579 8789 3630 8503 208 2932 2997 5255 5837 5792 7249 7248 5140 3991 6009 572 2475 6104 2872 2885 6654 3265 5604 10580 3643 3636 3632 5584 2308 204 57521 1978 50964 369 2002 3099 2998 5291 PMC12027419__F5 Identification of key players in burn injury-related REC network 222236 29940 57406 100379198 2166 PMC12027552__F7 Correlation network diagram of differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) in the plant hormone signal transduction pathway under the FR treatment 51411 1879 64641 7018 PMC12027629__F1 Keratinocyte-derived EVs modulate immune cells and promote inflammation in psoriasis 3576 6372 6374 2921 2919 7046 3458 920 PMC12027666__F1 Sphingolipid synthesis pathways 8877 6611 64781 1674 PMC12027666__F2 S1P-mediated signaling pathways 124976 1901 9294 6714 8877 6774 8698 53637 6010 PMC12027943__F5 Compound–target–pathway interaction network 5340 5578 4193 23541 142 3757 2932 1457 2099 6790 412 595 6868 7298 4306 2159 11200 1111 1509 4321 3312 5144 213 1719 5328 5447 5347 2950 2475 5294 217 6714 7274 207 2936 1956 5584 1230 3156 5781 7139 5581 2260 3480 PMC12028195__F1 DNA damage response (DDR) signaling pathway and DDR inhibitors used in clinical settings 472 10111 4361 1196 545 7465 672 993 79728 5371 995 675 5888 PMC12028518__F5 Expression of the GNPDA1 signaling pathway in breast cancer (MetaCore) 472 675 545 4803 998 3717 2099 10111 847 4436 1103 580 2100 5888 PMC12028784__F7 This study 7099 3569 7124 3383 7412 PMC12029365__F4 TME lactate signaling 220 29933 27198 2885 2475 374 5243 PMC12029499__F1 Vitamin D synthesis and activation pathway 4827 5212 1591 120227 1594 PMC12029571__F1 Main metabolic pathways involved in cancer 2744 1376 4609 PMC12029571__F2 Main metabolic pathways involved in cancer 1376 95 2194 6319 7038 PMC12029571__F4 UPR pathway 22926 7494 7186 468 PMC12029909__F5 Screening for maps of metabolic pathways involved in key differentially expressed metabolites 4118 11113 351 PMC12030371__F1 Penoxsulam’s Effect on Chlorophyll Synthesis and the Metabolism of Foxtail Millet 4556 4553 210 7390 7389 130749 5447 PMC12030433__F5 Carotenoid metabolic pathway 6476 5447 9973 PMC12031180__F7 CTN induces apoptosis and cell cycle arrest via the TGFB signaling pathway, and 4-HDK mitigates these effects 7157 1026 836 54625 PMC12031541__F1 Interaction of autonomous parvoviruses with cellular DDR factors 4361 10111 472 672 545 5888 3014 84126 11073 675 PMC12031541__F3 AAV life cycle and DNA Damage Response (DDR) signaling 4361 545 10111 3014 84126 11073 472 PMC12032003__F7 Working model of G-Rg1’s functions in protecting the synaptic plasticity and mitigating neuroapoptosis via the Hippo-YAP signaling pathway in the stress model 4485 26524 9113 7004 8463 7005 7003 PMC12032345__F1 STING signaling pathwayDNA from damaged mitochondria or pathogens can be recognized by cGAS, and cGAS subsequently catalyzes the formation of 2′,3′-cGAMP 115004 1636 11277 5167 29110 1777 51816 3661 3569 7124 PMC12033294__F7 MAPK signalling pathway (KEGG:04,010, 31 counts; https://www 4352 2885 6722 4763 4284 4149 2316 7124 355 1616 4208 929 23118 51295 1950 51701 PMC12033294__F8 cAMP signalling pathway (KEGG:04,024, 7 counts; https://www 7432 2695 4852 5020 1080 8205 51083 PMC12034127__F3 Iron overload activates the AKT/mTORC1 signalling pathway and inhibits TFEB expression, thereby inhibiting autophagy-mediated degradation of misfolded Alpha-syn and leading to neuronal death 7018 3481 7942 PMC12034266__F1 Sphingolipid biosynthesis and metabolic pathways 2531 8560 8879 64781 7357 PMC12034555__F1 Biogenesis of exosomes depends on two pathways ESCRT dependent and ESCRT-independent 7251 51160 51028 51652 11031 1956 8027 23102 967 254272 4827 3984 6093 5062 PMC12034555__F2 This figure shows the role of EV-associated proteins in TNBC progression through various molecular interactions: 1 1956 100133941 4851 102 960 6352 PMC12034555__F3 EVs derived from TNBC cells line can transfer various biomolecules to recipient cells, thereby modulated their biological functions 1956 309 9242 768222 4280 5897 4691 104472715 100130776 596 6777 2305 PMC12034657__F4 PI3K/AKT/mTOR signaling pathway activated by Sr 6668 846 2475 PMC12034699__F6 Expression trends of each molecule associated with the interferon signaling pathway based on gene chip analysis The interferon signaling pathway was significantly activated 581 3458 7297 8651 8554 10379 3659 5696 PMC12034760__F0 FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression 3516 2091 7528 790 PMC12034938__F8 Plantamajoside Promotes NGF/TrkA Pathway to Inhibit Neuronal Apoptosis and Improve Diabetic Peripheral Neuropathy 4803 581 596 PMC12035655__F10 Novel Wnt/Beta-catenin signaling gene signature for progression and metastasis of gastric cancer 165 1499 6929 2535 7431 8532 PMC12035766__F3 Molecular hydrogen alleviating IBD and intestinal injury 468 7494 100379198 324 79792 3458 PMC12035766__F4 Molecular hydrogen reducing intestinal I/R injury 8205 3654 51135 23118 7018 79792 5728 5163 PMC12035766__F1 Brief diagram of the mechanisms of molecular hydrogen 7099 7189 847 581 50943 920 7494 468 PMC12035885__F2 Crucial environmental factors associated with NK cell function in the TME of breast cancer 3065 6774 3002 3458 3559 3945 PMC12035885__F3 Main metabolites in the TME of breast cancer that affect NK cell function 2495 3135 3458 3002 100507436 4277 PMC12035886__F1 Mechanism of histone modifications in regulating enzalutamide sensitivity in advanced prostate cancer 80853 84444 367 105373241 10481 PMC12035886__F2 Histone modifications drive neuroendocrine differentiation in prostate cancer 283120 2146 367 6774 PMC12035889__F2 Signaling pathways inflammation and oxidative stress induced by LPS, HIS, iE-DAP and MDP 7099 929 3929 64127 10392 2475 7124 PMC12035889__F4 Mechanism of trained immunity and related research 7097 3480 7099 64127 2475 PMC12035894__F2 Carcinogenic mechanisms of estrogen and its metabolites in breast cells 1956 5594 7422 PMC12036158__F2 Regulatory pathways of ferroptosis 6520 23657 10162 2182 1723 5447 8031 847 1803 PMC12036158__F3 Regulation of epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF) by ferroptosis 7045 6520 23657 2879 571 PMC12037491__F7 Possible mechanism of central tolerance of thymic T cells induced by H 324 7189 9101 51510 7535 2885 PMC12037492__F1 Mechanisms via which TYMP promotes platelet activation and osteoclast differentiation 4067 2534 6850 7189 1890 4772 PMC12037492__F3 Mechanism via which TYMP modifies epigenetic and resists apoptosis TYMP catalyzes the conversion of thymidine to thymine and 2DDR, which binds to integrin AVB3/A5B1 on progenitor cells, thereby activating the PI3K pathway 1890 5163 4193 1788 860 3394 PMC12037536__F5 Multiple cytokines and signaling pathways in psoriasis is highly significant 84818 7297 3717 23765 6775 6774 55540 4615 51135 7189 7187 55364 3460 8717 4087 4088 4118 PMC12037972__F1 Overview of serine-glycine-one-carbon (SGOC) metabolic pathway 26227 29968 5723 PMC12038022__F2 Molecular mechanisms of ferroptosis and disulfidptosis 7037 23657 80224 4695 10128 54995 2997 6520 6184 55240 2879 2182 10162 5447 10787 PMC12038455__F1 Implication of miR-21-5p and miR-214-5p in regulation of signal transducer and activator of transcription 3 signaling pathway 9242 406997 406996 6774 PMC12038969__F4 Correlation between PYGO2 and IL10 expression through the Wnt/Beta-catenin signaling pathway in ESCC progression 324 1499 595 3586 90780 1956 PMC12039146__F7 Schematic diagram of lipid metabolism and its crosstalk with other metabolism pathways 5105 2194 3099 6517 9370 56034 2475 622 7038 57678 84649 57600 PMC12039932__F2 Nanomaterial-based DDSs treat OA by targeting macrophages 2475 7098 115004 7442 PMC12039932__F3 Nanomaterial-based DDSs treat OA by targeting synoviocytes 2475 8989 4314 4322 7124 PMC12039932__F5 Nanomaterial-based DDSs treat OA by targeting chondrocytes 596 581 89780 PMC12040673__F5 Inhibitory effects of supersulfides on the TLR signaling pathway 7099 114548 140609 PMC12040673__F6 Structural features and signaling pathway of RLRs 7097 10333 7099 114609 4615 7189 7098 8195 3661 7124 6772 PMC12040678__F2 Pathogenesis of HMGB1 in vitiligo 7099 3146 941 942 58191 10663 PMC12040678__F3 Pathogenesis of HMGB1 in psoriasis 7099 3146 941 942 149233 PMC12040678__F5 Pathogenesis of HMGB1 in alopecia areata 920 7099 3146 4040 PMC12040832__F1 Underlying protective mechanism of EOs against oxidative damage induced by chemical overexposure 4087 2475 581 596 9817 1571 847 5091 4353 PMC12040833__F10 Pathways (Beta-alanine metabolic pathway; monoterpenoid biosynthesis pathway; glutathione metabolic pathway) enriched by differentially expressed genes (DEGs)/differentially abundant metabolites (DAMs) 5182 51056 5184 PMC12040899__F10 SUMOylation and SAFB2 in PDAC Progression 113146 9667 3845 1499 PMC12041035__F1 Biogenesis, secretion, and structure of exosomes 967 928 3732 975 PMC12041035__F3 Exosomes mediate crosstalk between kidney cells 7124 7006 100124696 100616494 2192 3099 PMC12041035__F5 Exosomes mediate cell regeneration, repair, and fibrosis 4088 8651 3099 PMC12041090__F2 TGFB/Smads signaling pathway 4838 57154 64750 4087 4088 324 3716 3718 1499 6774 6778 6772 2475 4089 PMC12041090__F3 Mechanisms by which natural products ameliorate renal fibrosis 940 3566 7099 5728 4087 4088 4089 7248 7249 23410 3716 3718 23411 55626 596 4041 4040 115004 81030 1499 79844 29800 6778 29110 10195 8408 64798 6351 3661 3665 5879 PMC12041774__F1 Wnt/Beta-catenin signaling pathway 4041 4040 1499 324 PMC12041774__F3 Effect of angiogenesis in CRC 4041 4040 2932 1499 324 3569 PMC12041774__F6 Effect of TCM monomers, formulations and small-molecule inhibitors on the Wnt/Beta-catenin signaling pathway 79971 1540 1499 5879 23118 607 51701 51176 4609 PMC12041846__F6A DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity 3952 3351 3357 960 4314 8997 2767 10672 2768 4217 6714 5091 387 6262 2596 2308 4137 2932 3725 836 PMC12041846__F6B DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity 5074 50632 2778 2776 1311 4842 170954 1020 814 466 1390 1387 PMC12041846__F6C DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity 1103 6572 60482 1129 1132 1133 1128 3759 43 1131 3717 2776 1139 2534 9817 4780 7124 3569 4843 3162 596 7054 4804 PMC12041846__F6D DEGs from GSE49028 dataset of binge ethanol-treated mice on signaling pathways related to anxiety and locomotor activity 445347 1739 2036 9495 9463 4646 23426 80852 PMC12042381__F1 Neospora caninuminfection induced significant changes of metabolic profiles in caprine EECs 3098 2821 226 2597 55276 387712 2023 5315 3939 4967 PMC12042419__F4 Schematic illustration of NOTCH3 signaling pathway involvement in the pathogenesis of CADASIL 102 4854 387 6010 9794 3516 PMC12042445__F8 Antioxidant and mitochondrial protective effects of EPS in PD 9817 2729 581 847 PMC12042674__F2 Signaling pathways regulating melanin synthesis 4157 4286 7306 PMC12042829__F1 Annexin A regulates regulated cell death patterns such as autophagy, ferroptosis, and pyroptosis 7037 3146 9474 2475 6774 58484 9447 114548 79792 PMC12043450__F4 Signaling pathways associated with GH treatment for DOR 2690 3717 2885 2475 5594 581 23410 4851 100188776 PMC12043473__F2 Conversion from normal fibroblasts (NFs) to cancer-associated fibroblasts (CAFs) involves multiple molecular mechanisms 960 4092 4087 4088 4089 100306940 6774 3717 8651 2592 3482 4018 2069 10413 90865 6497 PMC12043473__F3 Origin of CAFs are complex, diverse, and heterogeneous 9242 6774 6387 PMC12043700__F2 Irisin in the regulation of MSC proliferation and differentiation 650 659 4093 4090 4086 2475 1280 860 176 6662 50964 1499 9474 9140 1050 2167 PMC12043700__F3 The improvement of osteoblast activity by irisin 50964 2475 1499 3939 5163 860 468 5744 PMC12043700__F4 Main regulatory mechanism of irisin in osteoclasts 4772 100187907 126014 PMC12043700__F6 Regulatory functions of irisin in osteoarthritis relief through modulation of chondrocyte metabolism 3554 7350 23410 7019 55669 114548 PMC12044029__F6 Bone-derived factors regulate renal functions 6446 3934 50964 22943 8074 1594 PMC12045470__F2 Protective mechanism of dexmedetomidine against multiorgan dysfunction 7099 3146 7124 114548 8031 50507 2475 6647 847 79792 581 PMC12045470__F3 Sepsis-induced lung injury 7099 127540 114548 2495 27035 7124 PMC12045470__F4 Sepsis-induced kidney injury 50507 114548 2879 7099 6647 23657 PMC12045470__F5 Sepsis-induced liver injury 2879 6647 7099 PMC12045470__F6 Sepsis-induced myocardial injury 114548 50507 8031 2879 7099 3146 PMC12045473__F3 Chloride channel regulation in human diseases 1080 55107 4312 3667 2475 144455 23152 PMC12045570__F2 Ferroptosis related signaling pathway affected by EBV, HTLV-I and KSHV viruses 23657 6520 30061 7157 467 2177 1026 8031 1723 2879 1803 23410 6303 5447 387787 1994 8678 PMC12045949__F1 Molecular Mechanisms Underlying ALKBH5-Mediated Regulation of Hepatic Glucose and Lipid Metabolism 2642 1956 54890 2194 2475 PMC12046027__F8 Interferon-Induced OAS-RNase L/PKR Pathway and the effect of hnRNP A1 depletion 7098 6041 4938 4939 91543 3434 3665 PMC12046282__F1 After CNPs enter cells through endocytosis, they induce the expression of TNFA and BMP2 650 7494 6774 114548 PMC12047224__F4 NFKB activation via the IKB degradation route is a common mechanism 1540 4615 3654 51135 7189 23118 257397 10892 8717 7186 7188 8737 9825 90268 PMC12047509__F1 Nrf2 signaling in Alzheimer's Disease 9817 2730 1728 23621 6376 7296 2879 9588 50507 PMC12048151__F1 How two mutations associated with developmental defects impact BMP4 secretion 652 655 56975 PMC12048993__F7 Macrophages with high expression of PD-1 inhibit their anti-tumor immune function 8205 3717 6774 PMC12049683__F3 TMAO inducing cell Apoptosis 7494 1409 114548 468 6774 PMC12049683__F4 TMAO inducing autophagic cell death 468 2475 9140 9474 55054 PMC12049683__F5 TMAO inducing cell pyroptosis 6390 217 581 114548 79792 1687 PMC12049683__F6 TMAO inducing cell ferroptosis 7018 55240 6520 23657 8031 2512 2879 PMC12049846__F7 Mechanisms 387 9223 6093 54 1513 81501 4772 PMC12050339__F7 Molecular pathways involved in the mechanism of mLV injury 7424 639 2303 9780 1956 1003 1524 5629 10894 PMC12052172__F4 Pathway network analysis based on genes annotated in eccDNAs 4204 2885 2064 613 860 861 847 5879 PMC12052642__F1 Schematic view of principal anti-tumor effects of resveratrol on different cancer-related mechanisms 1499 595 581 331 6774 PMC12052642__F2 Major signaling pathways regulated by resveratrol 4041 4040 324 1499 9817 5728 6774 PMC12052642__F3 PI3K signaling pathway in cancer onset and progression 5728 10000 208 581 572 331 4193 PMC12052780__F1 Wnt and PI3K/AKT pathways involved in macrophage polarization and metastatic progression in the tumor microenvironment of ovarian cancer 5728 1499 634 6348 6772 383 9332 PMC12052780__F4 Figure illustrates how various molecular factors drive TAM polarization and chemoresistance in the OC microenvironment 8904 10644 2254 387 10631 133 2358 2625 1316 6487 PMC12052780__F5 EVs in macrophage polarization within the ovarian tumor microenvironment 100506305 2625 100133941 11174 6720 2735 8850 1316 9021 3206 6774 23411 PMC12052831__F1 FAS mediates apoptosis, inflammation, and treatment of pathogen infection 8772 355 581 637 331 PMC12052831__F2 FAS mediates apoptosis, inflammation, and treatment of pathogen infection 355 8772 1950 1616 6774 6714 8737 50508 10454 23118 257397 331 PMC12052849__F5 Proposed working model of apoptosis regulated by USP18 through the PERK-eIF2Alpha-ATF4 signaling pathway 11274 468 581 PMC12052884__F1 Metformin in gynecological disorders: pathogenic insights and therapeutic implications 7099 23411 2475 PMC12055541__F4 Inflammatory Mechanisms Following SCI: In the acute injury phase: SCI directly causes vascular damage or severing, increasing the permeability of blood vessels 2920 3627 6347 2668 627 PMC12055541__F5 Molecular Mechanisms of Hydrogel in Improving the Microenvironment of SCI 7099 3479 627 114548 9817 4615 6774 6778 3550 383 581 1728 2879 PMC12055549__F0 Proposed signaling pathway of tetramethylpyrazine (TMPZ) in protecting against acute pancreatitis through inhibition of pyroptosis via the NRF2 pathway 4827 114548 79792 PMC12055817__F2 Possible mechanisms underlying crosstalk between microglia and astroglia 6347 6376 3627 114548 196 7423 7039 4843 PMC12055817__F3 Antidepressant mechanism of natural anti-inflammatory products 7099 114548 627 PMC12055823__F1 Nutrient sensing pathway and autophagy in diabetic nephropathy 8408 9776 7942 23411 9474 2308 10533 664 468 PMC12055823__F2 Oxidative stress and autophagy in diabetic nephropathy 2308 7248 7249 8408 2475 6009 23411 6774 65018 PMC12055823__F4 TCM ameliorates DKD by modulating mTOR-mediated oxidative stress and nutrient sensing pathways 23411 7249 6009 8408 2475 PMC12055897__F2 LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications 3725 5728 100506305 PMC12055897__F5 LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications 1956 1950 5728 100642175 441355 PMC12056003__F4 Genes modulated by the expression of IFITM1, 2, and 3 in HFF-1 cells 7706 4684 8205 1540 51284 64135 57506 10010 9755 7187 8717 29110 64170 8915 3455 3454 163702 7297 3716 51311 7098 6772 6773 54106 10379 1654 3439 3440 10910 4615 3654 7189 3661 3665 10454 23118 6885 8195 5604 3663 7124 4599 PMC12056003__F7 IFITMs on CHIKV infection in human dermal cells 3455 10379 7297 6772 6773 3661 3665 3663 PMC12056177__F10 Schematic description of kinase signaling pathways in Amyotrophic lateral sclerosis 84630 146057 2521 6647 203228 5728 4750 29110 8737 11035 197259 55255 8408 10133 112936 PMC12056177__F6 MAP3K-MAP2K-MAPK signaling pathway 2885 4216 4296 PMC12056177__F7 Schematic description of kinase signaling pathways in Alzheimer’s disease 23411 351 1938 23621 102 2534 627 2475 6774 2932 2065 1020 472 84630 995 993 994 3065 581 PMC12056177__F8 Schematic description of kinase signaling pathways in Parkinson’s disease 2869 120892 65018 7965 2580 2289 142 PMC12056177__F9 Schematic description of kinase signaling pathways in Huntington’s disease 2475 3479 3064 627 1020 PMC12056223__F7 Schematic summary of the role of targeting Dnmt3a mediated ID2 promoter in MMT 4087 4088 3398 1786 1788 PMC12056481__F2 DUBs in the p53 pathway, NFKB signaling pathway and RAS/RAF/MEK/ERK pathway in HNSCC 7874 1956 7375 1540 57646 4193 9100 PMC12056481__F3 DUBs in the PI3K, TGFB and HIF-1A signaling pathway in HNSCC 8975 5728 23252 5163 7398 2475 4092 4089 1540 7428 7345 PMC12056481__F4 DUBs in Wnt/Beta-catenin pathway, MYC signaling pathway and Hippo pathway in HNSCC 1499 324 4041 4040 2146 7874 4485 9113 23326 7347 PMC12056752__F1 RAS signaling pathway involves small GTPase switch proteins, NRAS, and KRAS 867 2885 9846 3845 4763 PMC12056752__F2 MicroRNA Signatures: Illuminating Minimal Residual Disease Monitoring in Juvenile Myelomonocytic Leukemia - A Review 5901 26523 27161 PMC12057185__F2 Processes of the three major classes for protein lipidation 9986 23463 3265 4893 6010 PMC12057185__F3 Comprehensive kinetic model illustrates dual lipidation interplay within the TME signaling pathways 3932 11074 27040 57506 324 2534 PMC12057185__F4 N-myristoylation in the TME 2255 6714 55004 2475 2180 355 637 613 695 375 572 6774 115004 3661 PMC12057185__F5 S-palmitoylation within the TME 54503 3939 131540 23390 25921 51114 55625 79792 51304 2475 84243 158866 PMC12057185__F6 S-prenylation within the TME 1956 2885 6009 64798 387 6010 6093 6850 283420 5879 154796 84766 PMC12057185__F7 Cohesive model of lipidation in the TME 920 4067 5879 5880 7124 613 3082 3939 100507436 4277 7099 3661 PMC12057268__F1 Interactions between chronic inflammatory pathways, MetS, and various skin diseases 7099 3565 3562 3479 7412 3383 1950 56244 60468 3559 10019 1956 PMC12058309__F1 Biosynthesis, metabolism and signaling of SA 1690 6295 4883 4881 PMC12058482__F1 Interaction between inflammatory response and alveolar epithelial cell injury 7808 90865 6774 114548 PMC12058482__F3 Molecular mechanisms of epithelial-mesenchymal transition 1950 4087 4088 4089 1000 1277 PMC12058482__F4 Severe acute respiratory syndrome coronavirus 2 infections and epithelial-mesenchymal transition 59272 7113 6714 7099 54209 6774 PMC12058719__F2 Osteoporosis (OP) regulation by protein arginine methyltransferases (PRMTs) (A)PRMT1 influences bone formation and resorption through the BMP2/Smad and other pathways, thereby mitigating OP 3276 7189 4487 4086 4090 4093 3627 91543 55170 10196 9242 54496 4200 5499 4921 PMC12058784__F3 Related biological functions in bone tissue 308 6778 2521 3146 PMC12058791__F1 Action of natural product-targeted modulation of PCD for the treatment of CRC 114548 79792 1687 9706 8408 9776 55626 2475 60673 22863 197259 11035 8737 8772 PMC12058791__F2 Natural products target ROS, P53, mTOR, NFKB, Beta-catenin and other signaling pathways to regulate apoptosis and play a role in intervening CRC 581 1499 1081 2475 PMC12058791__F3 Natural products target ROS, PI3K/AKT, AMPK, and LC3 signaling pathways to regulate autophagy and play a role in intervening in CRC 8408 2475 10533 64422 PMC12058791__F4 Natural products play a role in intervening in CRC by targeting signalling pathways such as Nrf2, GPX4, NLRP3, RIPK1, and RIPK3 and regulating different forms of cell death mechanisms such as Ferroptosis, Pyroptosis and Necroptosis 8772 11035 8737 55240 2937 2879 22861 58484 9447 114548 197259 79792 PMC12058831__F5 Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics 8443 8540 56994 PMC12059070__F7 Gemcitabine-induced cellular responses 6240 1111 6117 6118 6119 1786 5925 545 983 891 890 9133 142 9782 4001 9188 5425 9768 5424 57804 51514 6241 7083 51053 7884 26271 PMC12059313__F8 Isobutyrate confers resistance to inflammatory bowel disease through host–microbiota interactions in pigs 4280 94005 4615 114548 196 920 50943 PMC12059369__F5 Key signaling pathways involved in the therapeutic mechanism of andrographolide (AD) in diabetic nephropathy (DN) 183 256933 6774 6401 3383 4313 7412 207 7124 7018 1958 59330 572 351 4615 619501 1386 8213 5978 PMC12059460__F6 HPE inhibits allergic rhinitis by modulating the AMPK/SHP1/SHP2/STING signaling pathway 29110 6850 1956 PMC12060066__F4 Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies 7225 6722 2638 1267 387 572 3630 7408 PMC12060353__F8 Aseptic inflammation caused by acinar cell injury leads to local tissue hypoxia 3579 2919 1277 PMC12060536__F10 Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury 9518 117159 594857 23411 22809 1029 8192 1026 9361 4318 PMC12061282__F10 Schematic depicting the mechanisms by which miR‐31‐5p regulates M1/M2 balance in autoimmune dry eye 5027 4843 79068 PMC12061301__F7 AKT1 regulating cuproptosis in TNBC tumorigenesis 5163 2230 1737 PMC12061513__F4 Protein palmitoylation modifications are involved in regulating osteogenic matrix mineralization and differentiation signals 387733 657 659 4089 51303 4090 4086 84287 860 PMC12061715__F2 Detailed mechanism of GSK3B involvement in reduced protein synthesis 823 3667 3479 4775 253260 1499 PMC12061715__F4 Analysis of the mechanism of skeletal muscle atrophy from the pathway of decreased protein synthesis 2660 468 9759 4087 4088 1647 3717 4089 6774 9021 PMC12061915__F1 Macrophages in cSCC 958 4345 27242 1116 1513 3596 383 PMC12062509__F3 Copper in promoting tumor 1317 2475 475 5163 9706 8408 1397 9474 9776 5140 1956 3466 4015 142 4313 4323 29126 324 PMC12062509__F4 Copper-induced cell death 1317 2081 7494 581 578 9131 114548 538 23657 8737 79792 11035 197259 7099 2879 8887 2475 7942 9474 8408 PMC12062509__F6 Cuproptosis 4891 1317 538 540 2230 2242 11019 2653 1737 7353 PMC12063130__F2 Targets of JNK/p38 MAPK signaling pathway in OC drug resistance 5243 1843 8205 7124 891 595 983 1019 PMC12063284__F3 SMKIs-induced cardiotoxicity 1956 6714 467 23657 6774 PMC12063356__F5 Combined Ibr + AS treatment modulates both upstream and downstream effectors of the BCR (A, B) PI3K-AKT signaling pathways 933 6850 613 4067 695 29760 640 2885 8915 975 256933 930 6009 7249 5624 2638 8480 5728 5934 572 PMC12064105__F7 Mechanism diagram of XSBO against AD (drawn by Figdraw 2 6611 4512 240 4048 8644 PMC12065022__F7 Working model for the mechanism of quercetin on HCC 8974 2475 581 PMC12065104__F5 Molecular and signaling changes between a normal melanocyte and a melanocytic melanocyte 5728 4763 1019 1021 4193 3458 3466 3716 3717 6772 3659 PMC12065145__F7 Schematic diagram illustrates the mechanism by which high Hcy levels promote hypertension 3343 2876 3383 PMC12065391__F2 Inflammatory signaling pathways involved in MDS and associated therapeutic targets 7096 7097 114609 4615 6280 6279 51135 3654 945 114548 79792 PMC12065456__F2 Pro- and anti-tumorigenic effects of integrins on interaction between endothelial cells and particular tumor cells 5281 2475 3611 998 4513 6010 5879 6714 22918 948 4691 7412 1950 7186 79812 PMC12065456__F4 Summary diagram of the interplay between integrins and cancer stem cells in specific tumor types 145258 928 6935 1499 200424 6774 2064 8205 9314 PMC12065540__F4 Upregulation and downregulation of active factors, mRNA, and signaling pathways during the ulcer healing process 283120 5316 5728 4088 406993 406913 2879 581 1755 23411 407006 7076 PMC12065808__F1 Comprehensive network featuring genetic regulation and glucose, fatty acid, and glutamine metabolism in cancer 948 6510 2475 4609 355 47 27165 5091 1431 2271 PMC12065877__F1 Differentially expressed transcripts mapping to the canonical HIF-1A signaling pathway in shunt PAECs, as mapped by Ingenuity Pathway Analysis Canonical pathway analysis, p-value of 50943 6194 1977 3320 3091 8260 4193 7157 8453 6923 7428 9978 6921 5901 10399 405 328 10987 3725 8648 406925 5054 1026 4843 133 7039 7018 2056 3481 PMC12066067__F6 Samples for metagenomic analysis based on part of the basal metabolic pathways from the KEGG database 47 8775 6389 PMC12066244__F7 Action of Osteo‐F in osteoarthritis 8190 1280 3565 3596 PMC12066262__F1 Pancreatic intestinal lung pathway in acute pancreatitis 7124 3569 3586 PMC12066304__F9 Genome-wide association study and transcriptomic analysis reveal the crucial role of sting1 in resistance to visceral white-nodules disease in Larimichthys polyactis 115004 29110 3661 3665 PMC12066314__F9 Proposed model showing that apigenin promotes pigmentation through the c-KIT/Raf-1/MAPK/CREB signaling pathway 3667 5873 998 2885 79083 23373 4286 PMC12066429__F5 Metabolic pathway reconstruction of M 2821 7086 2597 192668 8772 PMC12066627__F1 Molecular and cellular signaling of intestinal tuft cells in response to infections 64806 5336 6689 1103 PMC12066772__F16 The mechanism by which Iso inhibits RANKL-induced osteoclastogenesis 7189 4772 4318 1513 PMC12066790__F10 Oncogenic mechanisms of HTLV-1 in adult T-cell leukemia/lymphoma 920 3050 3902 246243 84433 6722 2002 55294 4609 3662 9025 5111 10456 50943 1233 201633 6774 332 PMC12066790__F4 Oncogenic mechanisms of HBV and HCV in hepatocellular carcinoma 2645 355 7040 6774 1786 174 23137 79677 1017 619501 1499 1493 1956 3146 3099 10628 7015 PMC12066790__F5 Oncogenic mechanisms of EBV in gastric cancer 1786 6774 7057 80319 324 5728 3717 5290 3480 9245 3902 6367 10401 55193 4318 4313 9589 1869 22943 1601 637 572 3925 7422 8570 7428 3549 7077 999 1499 PMC12066790__F6 Oncogenic mechanisms of HPV in cervical cancer 545 1956 7454 1950 7015 8772 6366 6347 115004 6352 1874 355 4513 4609 1499 3091 3939 PMC12066790__F7 Oncogenic mechanisms of EBV in nasopharyngeal carcinoma 6098 1029 7048 2475 1956 196 2271 9817 2879 23657 572 545 8205 306 6367 7128 4087 4089 6774 3717 3939 3099 2746 2747 PMC12066790__F9 Oncogenic mechanisms of EBV in lymphoma 7454 4792 7345 4899 2551 4968 1803 6891 201633 6364 PMC12067395__F2 Interactions between tumors and copper 595 6647 475 5315 4609 1499 540 5163 3939 1956 4015 PMC12067419__F8 Possible underlying mechanism of AR inhibitors in the treatment of PAH 367 388585 4854 PMC12067647__F5 The cytokine-cytokine receptor interaction pathway in IIM patients with/without anti-MDA5+ autoantibodies 2921 355 85480 3976 1896 6387 3565 924 3623 7173 4352 268 3952 PMC12067746__F7 Graphical illustration of the working model 3624 4089 50943 920 PMC12067801__F4 ANO1 participates in various signaling pathways 55107 1956 2475 PMC12068291__F2 Graphical representation of normal functioning of Notch signaling pathway and its importance in controlling cellular and developmental processes 6608 2735 51684 4041 4040 324 894 7038 PMC12068639__F2 TRIM proteins positively regulate innate immune signaling pathways 115004 10475 10107 7706 89122 6737 5537 3716 7297 6772 6773 7098 201292 57506 9830 81844 10379 29110 3661 3665 81603 5300 85363 PMC12068849__F1 Canonical and non-canonical signaling pathways 4041 4040 5879 2932 324 387 998 1499 51701 PMC12068849__F2 Wnt/Beta-catenin pathway activation and inhibition 4041 4040 324 1499 100 PMC12068849__F3 Wnt signaling within the breast cancer TME 968 8205 7474 9332 1856 7422 6347 22943 607 27122 920 50943 1499 975 8829 100775107 860 6925 3091 8650 225 2736 100302242 6548 6259 6659 PMC12068849__F4 Interaction between the Wnt signaling pathway and other pathways in the breast cancer TME 6608 54361 89780 7482 7477 374654 51684 4041 4040 4087 4088 4089 6469 7474 6422 2294 2295 1499 2932 324 2248 5163 10818 2885 2549 8817 2475 26281 PMC12069117__F21 TREM2 signalling pathways 54209 102 27040 7462 3937 6714 7409 2885 6655 6850 867 PMC12069192__F2 Regulation mechanisms of LMM proteins in rice 5868 5933 64326 717 PMC12069211__F9 Construction of “KEGG pathway-target” network 207 4843 816 7498 367 1129 7099 7975 377677 9429 5243 1545 2099 1021 4318 3294 1645 3290 240 762 5209 1109 50853 5966 759 7054 4322 43 9536 57016 5144 PMC12069246__F3 P38 MAPK signaling pathway is regulated by ubiquitination in MASLD 7128 54461 10475 10626 55611 23118 7188 257397 7189 10454 1540 7375 7187 11274 PMC12069271__F4 Pathway diagram of lipid and atherosclerosis (available at https://www 5624 572 3067 929 100187907 6395 7099 10010 338 6774 6401 6403 114609 23118 7124 114548 4118 468 4703 7054 7436 842 PMC12069271__F5 Pathway diagram of the NF signaling pathway (available at https://www 7124 8717 4703 1540 8772 836 2919 2921 3569 3976 3600 9021 1896 6401 2353 331 197259 7186 7187 PMC12070570__F8 Schematic overviews of signaling pathways of enriched hypomethylated mRNAs in LMCI/Control 4023 28 341 847 7038 347 706 50975 572 351 6418 3416 907 90550 8772 948 22926 1311 256933 100 238 PMC12071082__F3 Therapies targeting RASGAPs in urological cancers 2146 367 472 153090 PMC12071115__F2 Relationship between the regulation of TFPI2 expression in cancer cells and host cells 56649 5660 4627 595 81 6249 114609 1950 3082 53615 4286 1786 7045 8205 PMC12071403__F4 Inflammatory Factors: A Key Contributor to Stress-Induced Major Depressive Disorder 5335 8915 10892 7188 9618 7187 7189 7185 7186 4050 5971 PMC12071403__F6 Correlation between stress-mediated inflammation and major depression 1979 1591 100287226 6231 2475 7368 54541 4915 26118 5631 1848 3399 3065 10231 3562 5562 11118 6503 PMC12071759__F1 TAM metabolization pathway 1576 1543 1544 1559 1565 1571 1557 1577 1545 54657 54576 54575 PMC12072112__F1 Insulin signaling pathway regulating glucose uptake and storage 3667 5163 2475 PMC12072112__F2 Interaction between insulin signaling, inflammation, and oxidative stress in cellular metabolism 7038 2885 3667 5163 2475 2932 PMC12072112__F5 Insulin resistance, neuroinflammation, and tau pathology in Alzheimer’s disease 7099 3416 2475 5163 2932 PMC12072309__F1 Schematic illustration depicting the dysregulation of the NF2/Merlin-Hippo signaling cascade in mesothelioma cells 10413 84962 4485 26524 9113 PMC12072370__F4 Knockout of StNADC has devastating effects on NAD synthesis and activates plant senescence and tuberization pathways 4817 56954 6390 6389 55270 65220 128240 5169 51733 7491 22933 10135 PMC12072397__F2 The osteoclastogenesis signaling pathway and its lncRNA-induced regulation 100270680 55000 107985249 285958 126014 54209 7189 23411 6773 6772 6850 29760 9846 2885 7503 27250 60674 3394 9935 7005 378938 4772 867 1513 100187907 4286 8651 387 PMC12072397__F3 The osteoblastogenesis signaling pathway and its lncRNA-induced regulation 147111 9350 6422 284654 54894 55366 84133 7473 50964 25805 8650 4041 4040 22943 27123 10023 1454 57291 1499 100316868 64321 55000 2239 8646 4681 9241 6259 4920 4919 27130 5879 387 23411 5663 6477 9475 27101 6500 324 8454 6093 25776 5578 4089 4088 2033 378938 1501 6932 51701 1749 8061 4316 3725 4609 860 100124700 10984 3397 PMC12072856__F1 Bacteria antagonize p53 protein by mechanisms of its destabilization or by reducing expression of its mRNA 1956 7099 4193 PMC12073115__F4 Mammalian RNA-dependent mRNA amplification is enabled by the integrated stress response 468 22809 1998 115209 9812 PMC12073235__F1 Primary to specialized metabolic flow in Cannabis 196743 6303 15 1312 PMC12073286__F8 Schematic diagram indicating how SP protects ALD mice via the multi-target regulation of the CYP2E1/Keap1/NFKB signaling pathway 9817 1571 847 PMC12073561__F5 Small RNAs are involved in the regulation of plant female gametophyte development 5300 377 192670 382 PMC12073636__F1 Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk 594857 4583 7099 4615 3630 PMC12073904__F7 Mechanistic model of inflammation, mitochondrial dysfunction, and neuromuscular junction characteristics of HF and LF octogenarians 9518 26291 133 51129 65220 64802 4685 2149 1013 627 4747 351 375790 1525 PMC12074830__F5 TLR signaling pathway 7099 1356 7097 4615 7187 7189 3663 3665 PMC12074965__F2 Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing 360 5236 7360 2582 2584 51083 PMC12074965__F5 UDP-GlcNAc And CMP-Neu5Ac Synthesis In Mammary Epithelial Cells: In the cytoplasm, glucose (Glu) enters the cell via glucose transporter 1 (GLUT1) and is phosphorylated by hexokinase (HK) to form glucose-6-phosphate (Glu-6-P) 360 2821 6675 10020 54187 140838 55907 PMC12075064__F2 Pathway insertion strategy into a Δadh P 572 1636 7054 3045 100187828 PMC12075242__F3 ETBF promotes tumorigenesis by distinct mechanisms 920 6774 7099 10725 57721 84844 79923 2648 PMC12075242__F5 Fn involved in immunotherapy 115004 27010 3661 PMC12075250__F2 AECAs pro-apoptotic and pro-inflammatory effects in ECs 581 355 8772 3383 7412 PMC12075257__F7 Schematic model showing the role of WED in regulating megakaryocyte differentiation and platelet generation 4280 2623 2353 PMC12075545__F6 IFN-Gamma-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy 285 2308 3716 6772 PMC12075957__F11 Canagliflozin alleviates progestin resistance by suppressing RARB/CRABP2 signaling in THRB knockout endometrial cancer cells 7068 581 6957 1382 5915 6256 PMC12076214__F3 Multifunctional cytochrome P450 orchestrates radical cleavage and non-radical cyclization in 5-oxaindolizidine biosynthesis† 717 6670 6668 PMC12076877__F3 Aryl hydrocarbon receptor: a new frontier in male reproductive system 196 405 57491 PMC12076972__F5 KEGG enrichment results related to the potential targets of Gyp LI 1956 5465 10855 27250 2147 7422 6714 1017 3815 PMC12077450__F2 CysLTs in lung injury 64806 3146 90865 8288 4155 7124 PMC12078210__F2 Pathways of Allogeneic Antigen Recognition and the Impact of IL-21 on DCs 1236 942 940 920 PMC12078438__F5 NI-ADSCs activating the Notch pathway to promote nerve regeneration by inducing and maintaining the reparative phenotype of Schwann cells 4851 3280 2670 PMC12078810__F7 ART inhibits hepatocellular carcinoma cells 4615 7189 7099 PMC12078813__F8 TD formation 1950 4088 999 PMC12079090__F10 PAX7 in Breast Cancer Prognosis and Its Mechanistic Involvement in the Wnt/B‐Catenin Pathway 1499 4041 4040 5081 595 PMC12079191__F1 Diagram of the ICG-CuET@PLGA-CS-HA (IC@PCH) nanoparticle (NP) synthesis procedure 1431 4827 114548 960 PMC12079202__F6 Overall network diagram of “drug-target-disease-pathway” 5327 5728 5328 581 PMC12080384__F2 Mode of action of non-coding RNAs in tumors 6774 339290 367 6667 100874253 4193 7157 5728 PMC12080384__F4 Multifaceted roles of RBP-regulated non-coding RNAs in tumors 3183 2521 6774 3091 29102 5728 58517 4609 51035 9113 4771 961 3845 10026 23543 2643 7037 PMC12080399__F11 Mechanistic diagram illustrating the detrimental effects of TRMT10C in the nucleus under hypoxic conditions via m1A modification 54931 1374 3840 6901 51441 79671 114548 PMC12080488__F4 Figure illustrates the JAK/STAT signaling pathway and its role in cancer progression, highlighting its influence on tumor invasion, progression, autophagy, and apoptosis 6774 6935 3569 3726 7291 2932 PMC12080927__F6 Distribution of targets in the MAPK signaling pathway 4351 2885 2002 6722 4149 2316 7124 7186 355 1616 4208 929 23118 51295 51701 1950 PMC12081031__F1 Schematic displaying the unfolded protein response signalling pathway 22926 7494 468 PMC12081031__F3 The promotion of EMT by XBP1 7494 6935 9839 PMC12081257__F1 Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression 9817 7296 2730 2729 1728 PMC12081406__F1 Biosynthetic pathway of sphingosine 1-phosphate and related molecules 8877 56848 6611 1674 64781 PMC12081410__F11 Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway 5170 207 1019 1017 5111 PMC12081606__F7 Working model 665 139341 4899 PMC12082737__F3 Canonical wnt signalling pathway (Kharaishvili et al 324 1499 11197 PMC12083488__F1 Tryptophan metabolic pathway 196 405 57491 PMC12084380__F2 Sepsis induces aberrant aging of immune cells which further exacerbates excessive inflammation 7099 7852 1401 929 9332 23475 5055 940 941 952 472 23476 836 958 PMC12084380__F3 Prematurely aged immune cells during sepsis contribute to immunosuppressive state 90865 7852 920 940 939 941 55686 PMC12084380__F4 Distinct phenotypic and functional alterations in immune system in aged individuals with sepsis compared with young patients 10320 688 6774 7099 54209 9927 2532 2919 114548 PMC12084380__F5 Therapeutic strategies targeting immunosenescence 4280 7124 952 472 2194 54209 PMC12084448__F1 Metabolic pathways in NENs 948 7038 2194 2475 47 55902 6510 PMC12084448__F2 Lipid metabolism changes in NENs 2171 2194 1499 54890 10644 2475 3157 10858 PMC12084448__F4 Metabolomics study in NENs 3170 3624 4088 4087 4089 4286 92 93 PMC12084451__F7 The differentiation paths of gastric epithelial cells and signaling regulation 4586 1950 51043 2104 496 1113 1114 7494 4588 PMC12084487__F2 Specific signaling pathways mediated programmed cell death in tumor microenvironment and target therapies 8737 8772 828 11035 197259 81030 23118 PMC12084487__F3 In the mTOR signaling pathway, PI3 K/AKT/mTOR axis can induce the occurrence of apoptosis 26135 64798 64223 2879 23657 9675 572 581 8408 8737 8767 PMC12084782__F7 Graphical abstract of this work 4087 4088 4089 1634 PMC12084948__F2 Signaling networks downstream of SLAMF receptors in regulating immune cells 717 6714 6504 4035 6850 9046 1796 7409 114836 57823 PMC12084948__F4 SLAMF receptors modulate cancer progression 57823 56833 619501 6347 PMC12084965__F7 Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis 51083 7124 114548 79792 PMC12085564__F7 Cardiomyocyte specific CD38 deletion protecting heart from acute myocardial infarction 581 596 23410 952 55669 9927 PMC12086034__F4 Visualize the KEGG enrichment results and mark the positions of hub genes 177 2475 2638 1101 5747 7422 5728 759 51083 6256 3265 7975 842 572 351 PMC12086142__F1 Regulatory mechanisms of NLRP3 inflammasome in PF 4615 7040 4087 65018 114548 140609 5209 79792 4088 4089 7045 PMC12086171__F8 Differentially expressed genes in memory CD4+ T cells from donors expressing HLA-DRB1 alleles 3566 10219 920 7535 27040 6364 6348 201633 6351 22914 2920 3576 51348 3458 4818 3002 940 3902 3823 3601 3557 3821 596 7040 51027 50852 3575 1043 939 1493 355 151888 3001 3003 7294 4050 22807 PMC12086256__F5 Interactions of vascular endothelial growth factor receptors (VEGFR) with co-receptors and structural features of Neuropilin 8828 2260 6395 2247 960 2043 1956 PMC12086256__F6 Signal transduction of vascular endothelial growth factor receptors 2549 6461 2534 1398 2885 100420631 6714 5062 PMC12086256__F7 Negative regulation and fine-tuning of VEGFR2-mediated signaling pathways 6714 5335 7422 PMC12086256__F8 VEGF/VEGFR signaling controls angiogenesis and vascular permeability 5091 1003 6714 PMC12086256__F9 VEGF/VEGFR signaling under pathological conditions 7422 7423 5281 7424 6714 4318 PMC12086632__F2 The H2S–NO–HNO–TRPA1–CGRP pathway as a crucial element in migraine pathogenesis 4357 875 8989 PMC12086986__F7 Magnolin mitigates CXCL10‐induced skin ageing 51083 7808 3627 2833 PMC12087080__F2 miR-155 participates in multiple cellular functions 3569 3716 6774 7428 387 4089 PMC12087080__F3 Mechanistic overview of miR-155 in regulating insulin signaling and glucose metabolism 7099 8651 5132 5163 PMC12087082__F4 Purine metabolic pathway 158 132 353 1544 4836 9397 PMC12089637__F7 Proposed mechanism of LRRC56 regulation BC progression via RhoA/ROCKs axis 387 115399 8100 1072 10413 PMC12089955__F5 Proposed mechanisms of action for L. sakei LB-P12 in OA 7124 4322 2034 PMC12090520__F9 Mechanism by which F1929-1458 activates anti-tumor immunity 4790 3146 115004 1236 941 PMC12090542__F1 Five signalling pathways in regulating the immune microenvironment of DW 4087 4088 5163 2475 4041 4040 6714 1499 324 4089 7018 51176 PMC12090549__F1 Adenosine production and signaling pathway 4860 100 952 PMC12090549__F4 Immunosuppressive effects of adenosine within the tumor microenvironment 6387 920 7124 4513 942 941 PMC12090549__F5 For combining inhibition of the adenosinergic pathway and other cancer immunotherapies 100 940 324 PMC12090635__F1 Composition and activation of Notch signaling pathway 3714 182 54567 28514 10683 PMC12090635__F2 EMT and Notch signaling pathway 56243 63933 10098 4092 86 23385 6774 4851 102 149603 PMC12090806__F7 Role of TRIM22 in antiviral immunity 29110 79671 57506 10346 3661 1999 PMC12090863__F1 Paclitaxel, interferons and functional reprogramming of tumor-associated macrophages in optimized chemo-immunotherapy 8205 7099 1234 2833 6352 4283 3627 6373 3458 3146 3577 7852 PMC12091695__F1 Simplified schematic representation of steps linking dyslipidemia with macrophage/microglia induced RNV 54210 95 3949 38 3569 7124 PMC12092085__F1 Magnesium promotes osteogenesis 54822 121340 9242 PMC12092085__F4 Biodegradable magnesium-based implants inhibit osteoclast differentiation through multiple mechanisms 7186 7188 7189 4772 PMC12092085__F8 PTH reduces the binding of RANKL to OPG by inhibiting the secretion of OPG from osteoblasts and acting on the cAMP-PKA-CREB and PP1/PP2A-CRTC3 pathways 5741 23387 23235 64784 3725 PMC12092303__F1 Main physiological functions of O-GlcNAc in the central nervous system 6657 6774 2736 8473 406 10724 PMC12092303__F2 Molecular targets and mechanisms of O-GlcNAcylation in the central nervous system 8473 7054 10724 406 2475 181 2736 6657 6774 387 6469 PMC12092457__F1 SPC25 is an important part of the NDC80 centromere complex 57405 83540 10403 PMC12092457__F2 SPC25 can be used as a scaffolding platform to coordinate the assembly of the SPC25/RIOK1/MYH9 trimer complex, triggering RIOK1-mediated phosphorylation of MYH9 Ser1943 10403 57405 83732 4627 PMC12092528__F4 RhoA/ROCK signaling pathway and Tau 6010 2932 5728 PMC12092922__F2 Biological function of MXRAs 8573 3611 6714 9124 6010 55605 79812 3490 7076 2335 1956 439921 PMC12092922__F4 MXRAs is involved in chemotherapy resistance 3611 6714 439921 54587 PMC12093320__F1 Genes encoding downstream NFLs evolve at a slower and more consistent rate comopared to genes encoding upstream NFLs 10475 27122 26524 9113 64399 59307 5727 10370 8313 8651 3280 1848 1499 PMC12093341__F1 Biosynthetic pathway of CR and strategies used in this study 2593 443 84890 PMC12093350__F1 P2X7R in Retinal Diseases: A Review 958 114548 79792 PMC12093937__F1 Niche for normal and cancer skin stem cells 6935 6929 8205 355 PMC12093937__F2 Core signaling pathways in skin stem cell niche 1499 2736 26524 9113 324 4485 60485 999 6469 6714 6774 2475 PMC12093937__F3 Signaling network in skin cancer stem cell niche 4286 7474 1499 2736 9113 324 2932 4485 60485 999 6608 5727 6469 6714 6774 26524 7291 6935 2475 6929 5077 PMC12093937__F4 Drug targeting on skin cancer stem cell niche 6469 6608 2736 2735 324 1499 4286 5077 6774 2475 6714 PMC12094478__F3 Mechanism of EVs in AKI 9817 922 10533 4280 23410 PMC12094572__F1 Effects of ADPN on metabolism in peripheral organs and related signaling pathways 3600 2308 51094 PMC12094572__F3 Molecular mechanisms of exercise-enhanced brain neuroplasticity by enhancing various peripheral factors 114548 51094 152831 26291 26060 PMC12095056__F4 Cilia and ciliary signaling contribute to therapeutic resistance 596 8837 6657 79923 5243 9429 472 545 PMC12095308__F4 Antiviral type I interferon (IFN) response pathway and known evasion mechanisms of orthohantaviruses 7099 7187 29110 57506 7706 7098 3665 3661 51284 51311 54106 7189 10379 3454 3455 7297 6772 6773 PMC12095467__F8 125I particles inhibit the progression of cervical cancer by up-regulating the HSF1/PU 6688 6850 3297 7494 468 23476 7874 PMC12095689__F4 Cotadutide enhances hepatic insulin-stimulated signaling pathways in DIO mice 3643 2885 3667 8660 5728 5286 5163 7248 7249 64798 64223 648791 2998 5836 23367 6194 1356 PMC12096500__F8 Proposed mechanism of PSVII treatment in psoriasis involves the modulation of the STAT3/NFKB signaling pathway and the regulation of pyroptosis 6774 114548 79792 3606 PMC12096525__F11 a) LDH-mediated NT3 delivery enhances spinal cord repair: axonal regeneration and functional recovery in a murine model 9780 6656 9242 1000 4133 5080 PMC12096540__F1 Key reactions involved in glycerolipid synthesis in plants 355 5091 4018 51083 PMC12097394__F3 Extrinsic and intrinsic apoptosis signaling pathway and involvement of E3 and DUBs 389856 7874 9100 23358 581 8772 8717 317 PMC12097394__F4 Involvement of E3 ligases and DUBs in calcium handling 867 29761 126119 6262 11065 8078 PMC12098228__F1 Baicalein and baicalin suppressing proliferation in colorectal cancer 5111 1499 22943 581 595 2475 1019 4193 PMC12098228__F2 Baicalein and baicalin significantly influences apoptosis in colorectal cancer cells 5111 4313 4318 581 442893 1647 891 595 PMC12098228__F3 Baicalin inhibits colorectal cancer metastasis by targeting key migration and invasion pathways 581 331 1000 960 999 6657 79923 595 891 898 PMC12098375__F1 Regulatory mechanism of ERK1/2 signaling in promoting insulin secretion and insulin resistance 1950 3667 2885 PMC12098830__F4 Innate Immune Signaling pathway in CVDs 7097 7096 7100 7099 4615 51135 3654 7189 23118 257397 7098 7187 51284 29110 3661 3665 51311 54106 10392 114548 79792 64127 8767 10454 81030 9447 91662 83666 115004 51428 57506 10000 718 715 716 717 3428 721 834 727 729 730 PMC12098830__F6 Other immune signaling pathways in CVDs 4485 4041 4040 26524 9113 1499 324 29110 3661 3665 PMC12098830__F8 Integration of key signaling pathway in CVDs with immune response 1950 1956 9817 759 PMC12100627__F9 Mechanism by which rSPD promotes in vitro replication of IBRV 7099 3654 7189 4615 3656 6772 7297 6773 54106 6348 3553 6279 10379 9636 4939 4599 91543 3434 PMC12102218__F8 Diagram illustrating the mechanism through which ISM5939 potentiates antitumor immune responses 115004 5167 325 PMC12102305__F9 Graphical abstract shows the unique characteristics of neuron damage in the SN of PD mice due to oligodendrocyte and astrocyte crosstalk 2879 23657 2260 2246 2263 2254 2261 527 4697 PMC12102898__F1 PI3K/Akt and Ras/MAPK signaling pathway processes and associated ubiquitination 8216 131405 2885 5163 8405 4734 5728 7189 55294 7248 672 6009 PMC12102898__F2 Wnt/Beta-catenin signaling pathway processes and associated ubiquitination 324 8312 201292 54894 81847 1499 144165 PMC12102898__F3 NFKB signaling pathway processes and associated ubiquitination 613 958 4055 5335 5336 7189 4615 7187 3654 8717 7186 7188 8915 10892 23151 83737 5971 PMC12102898__F4 HBV virus structure and related immune ubiquitination process involving HBx protein 115426 1660 1499 324 4734 7189 619501 3161 23650 PMC12102898__F5 Diverse E3 ligases participate in the modulation of multiple signaling pathways via the ubiquitination process, playing crucial roles in either immunological activation or immune evasion through specific mechanisms 115123 142 4850 6774 3717 619501 1019 1021 6737 9774 8405 7054 4077 22954 29110 PMC12102912__F9 Mechanistic illustration: ITGB3-knockdown enhances osteogenic differentiation and radiosensitizes osteosarcoma cells via JNK/c-JUN/RUNX2 pathway activation 3674 3685 3690 860 581 PMC12102949__F2 Illustrates Various Molecular Mechanisms Facilitating the Formation and Survival of DTPs under Targeted Therapy and Immunotherapy 9869 2146 8473 7403 79068 338 9582 5426 6657 429 5469 23476 2305 8289 6597 6599 2247 2885 2475 1499 29881 2879 1103 PMC12102949__F3 Multiple Cross-linking Mechanisms among Tumor Cells or/and the Surrounding Environment Sustain the Formation and Persistence of DTPs under Targeted Therapy and Immunotherapy 2264 939 970 2475 1499 7018 8744 6356 2252 6387 2919 3458 3082 170392 PMC12103044__F10 Examples of eExo for promoting chronic wound healing 7099 283120 5728 55662 6774 4088 23411 23410 2475 PMC12103044__F4 Triggers and pathogenesis for pathological scar formation 3091 4615 4087 4088 3654 387 4092 64750 23118 257397 1540 4089 PMC12103590__F8 Proposed model of hnRNPL phase separation promoting glycolysis in ovarian cancer 3191 5291 5208 PMC12103767__F6 Proposed hippocampal signaling pathway altered by early amyloidosis 196500 3479 347252 51599 3097 1600 348 10645 2932 4761 5534 1827 1387 PMC12103778__F4 Cytoneme-mediated self-organization and asymmetric cell division in stem cells 7474 89780 1499 PMC12103778__F5 Cytoneme-mediated Wnt signaling in gastric cancer 4920 7474 4041 4040 7473 PMC12103977__F1 Comparative framework for the integrative analysis of cardiovascular phenotypes 8660 207 4625 PMC12104071__F2 Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis 5163 5728 6009 PMC12104164__F3 Signaling pathways related to fibrocartilageThe complex network of interrelated signaling pathways is involved in the generation of fibrocartilage, including TGFB/SMAD, WNT/Beta-catenin, Hippo, PI3K/AKT, and NFKB 4485 5728 5163 26524 9113 5970 1499 2475 7018 51176 7004 8463 7005 7003 8161 PMC12104182__F3 Possible mechanisms by which periodontal pathogens may promote activation of the Wnt/Beta-catenin pathway during oral carcinogenesis 847 1855 324 2932 PMC12104183__F4 Signaling pathways involved in the protection of H2S against PH 22926 355 3383 PMC12104300__F1 Eph/ephrin signaling in oral squamous cell carcinoma (OSCC): regulatory pathways, tumor progression, and therapeutic implications 2050 4597 1956 2046 79923 2475 2041 2043 2045 1969 1944 1945 284656 2051 PMC12104300__F2 Interactions of the Eph/ephrin system in adenoid cystic carcinoma (AdCC) 1969 1942 493812 PMC12104430__F7 The OMD-induced regulation in hDPSCs upon LPS stimulation 4958 3554 114548 7124 PMC12104568__F2 CTLA‐4 mediated inhibition in T cells 324 3932 940 941 942 5163 2475 PMC12104694__F1 Indole‐3‐acetic acid (IAA)‐mediated signaling pathways in epithelial and endothelial cells 7099 2048 4615 196 1499 4583 55230 405 7006 100124696 9060 PMC12105125__S1 Schematic diagram of this study 5091 7124 3569 3627 3661 PMC12105201__F8 SLC3A2 and SLC7A5 in the pathogenesis of OA 6520 8140 4322 2475 PMC12105221__F2 Estrogenoids contribute to the development of uterine fibroids through alterations in epigenetic pathways [17, 56] 1674 3488 10873 2662 PMC12105221__F3 Several classical mechanisms of EDCs that contribute to the development of endometriosis [79, 80] 196 405 50943 4318 4313 PMC12105221__F4 How BPA contributes to the development of endometrial hyperplasia, endometrial cancer and infertility through DNA methylation alterations [12, 100] 5979 4582 2199 3934 1789 1786 8932 9464 PMC12106265__F3 ER stress in DILI 22926 7186 7494 468 PMC12106287__F1 Membrane receptor tyrosine kinases-linked anti-BC effects of flavonoids as modulators of the MAPK signaling pathway, highlighting their capacity to function as sensitizers in chemoresistant BC and/or as chemopreventive agents 998 6010 6722 1386 PMC12106324__F5 Canonical TGFB signaling via Smad signaling pathway 4092 4091 57154 64750 4089 PMC12106402__F1 Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities 10157 132949 3033 51166 55526 2639 PMC12106438__F2 Molecular mechanisms of intracellular lactate production and export 2744 5132 3939 PMC12106438__F3 Effects and mechanisms of lactate on macrophage polarization 8205 3091 3099 383 51660 8477 3146 PMC12106489__F7 Wnt7b promoting renal fibrosis in AAN 324 7477 64840 1499 PMC12106535__F6 The apoptosis-related gene/tumor-associated antigen MUC1 in mesenchymal stem cell-mediated treatment of IBD 9242 4582 7099 920 23657 10162 2879 5447 PMC12107760__F9 Changes in the main metabolic pathways of wheat root system in response to Act12 inoculation under drought stress 1633 5053 162466 PMC12107871__F1 Inflammatory signaling mechanisms underlying cancer development mediated by the NF-kB signaling pathway 1950 613 1956 6347 3576 595 4055 5971 596 7852 PMC12107871__F2 Graphical depiction of mechanisms responsible for inflammatory response mediating the onset of cancer via STAT3 signaling pathway 7039 6774 1956 7472 2535 595 332 7852 PMC12107871__F3 Schematic description of the signaling process demonstrating the intricate cross-talk between NFKB and STAT3 in inflammation-induced cancer 7124 6774 4313 4318 581 596 PMC12107871__F5 Proposal of the main molecular signaling pathways by which celecoxib exerts its anti-inflammatory action as a promising strategy in breast cancer therapy 4512 920 7054 PMC12108002__F2 Major signaling pathways and transcription factors in BMSCs 650 2638 6497 1499 860 PMC12108044__F5 KEGG pathway enrichment analysis 7124 100187907 367 PMC12108254__F2 Steps involved in irisin production and the molecular cascades underlying its biological functions 6774 4915 7099 5594 5595 2475 842 627 6721 7350 3717 PMC12108277__F5 Summary schematic diagram of the mechanism by which miR-129a-3p negatively regulates the inflammatory response to G 5066 7099 4615 PMC12108420__F12 GnRH signaling pathway involves multiple molecular interactions regulating gonadotropin gene expression and secretion 2798 2638 6714 998 3725 4313 1950 1956 2885 5894 2002 PMC12108454__F1 Primary etiological factor for PMOP is estrogen deficiency 50964 22943 4041 4040 1499 860 PMC12108454__F2 New Perspectives on Postmenopausal Osteoporosis: Mechanisms and Potential Therapeutic Strategies of Sirtuins and Oxidative Stress 860 6648 51548 23411 23410 100187907 1513 4772 PMC12108454__F3 OS leads to the overproduction of ROS 23411 23410 6648 51548 2879 3611 860 PMC12108521__F1 Molecular mechanisms of ferroptosis and key regulatory pathways 55240 2879 2182 10162 PMC12108893__F4 In malignant cells, the biosynthesis of fatty acids and cholesterol both use acetyl-CoA as the starting substrate 3949 2194 3156 47 948 355 PMC12108901__F7 Comprehensive model of nitrogen and phosphorus interaction at different levels 1610 55272 5183 PMC12109257__F6 MicroRNAs in oral cancer progression 29102 54487 2113 2002 27161 1956 4609 5901 PMC12109299__F1 HER2 signaling 1956 5728 7249 7248 5163 PMC12109684__F7 Schematic diagram illustrating the proposed mechanism by which AHE-EA-C exerts its anti-leukemic effects in AML cells 1019 595 581 PMC12109847__F2 AKT signaling pathway is known to be regulated by miR-21 through the targeting and suppression of the tumor suppressor phosphatase and tensin homolog (PTEN) 5163 7248 7249 6009 5728 PMC12109847__F3 MiR-21 modulates the MAPK/MEK/ERK signaling pathway directly by downregulating the SPRY and DUSPs that normally suppress ERK activation 2885 5894 2002 1386 6772 PMC12110123__F4 Ginsenoside CK inhibits the expression of AKT/mTOR/p70S6K1 proteins and blocks the PI3K/AKT/mTOR signaling pathway in cancer cells, reducing the expression of MMP2 and MMP9 proteases 2475 4318 4313 PMC12110123__F5 Anticancer Mechanisms of Ginsenoside Compound K: A Review 7852 4318 4313 PMC12110123__F9 Ginsenoside CK can enhance the expression of CD69, CD80, and CD86, stimulate the NFKB and AP-1 inflammatory signaling pathway, and induce macrophages to secrete iNOS and TNFA to enhance inflammatory response 3732 969 942 941 PMC12110399__F3 LGR5 potentiates the WNT–Beta-catenin signaling pathway that maintains the stem-cell-like phenotype, impeding cellular differentiation 8549 54894 4041 4040 84133 PMC12110588__F3 Structure, conserved motifs, and anti-interferon activities of programmed death-1 ligand 1 3716 3717 6774 840 PMC12110659__F1 Immune Resistance Mechanisms 3596 3606 3569 3565 56477 3586 3567 3717 3659 PMC12110659__F2 Autophagy regulation by glycolysis 2475 6009 2597 6774 PMC12110659__F4 Targeting autophagy to enhance anti-PD-1/PD-L1 therapy 960 920 4077 PMC12110717__F2 Schematic view of membrane channels, Ca2+ and inorganic phosphate (Pi) ion trafficking and amorphous calcium phosphate (ACP)/HA formation 9759 54499 116337 PMC12110894__F7 Expression changes of key enzyme genes for flavonoid synthesis pathway in different light treatments 108348016 4881 4597 51411 2224 8213 PMC12111366__F1 Hemp iron plays a role in muscle regeneration, lipid metabolism, and cholesterol management 7036 654 148738 3077 PMC12111433__F6 This illustration depicts the pathways and key genes involved in the synthesis of chlorophyll and SGAs during the photoinduced greening of potato tubers 7389 5447 64326 6746 PMC12111560__F5 Expression profile of candidate genes involved in the organic acid metabolic pathway in pomegranate 4199 4397 1431 PMC12111645__F7 THC-induced neurotoxicity Via MCU 221154 114789 79085 90550 8011 PMC12111897__F6 Signal transduction pathways for the Al+ADAl3–4 vs 54903 578 404685 1879 64641 4881 7018 51411 PMC12111917__F7 Signaling pathways activated by exogenous sVASN treatment in different cell types 3689 10207 1495 999 23286 7005 7042 25937 3993 4086 154796 80326 56288 182 84441 6310 8605 10413 3280 3065 6774 9470 5595 4790 1436 3454 3643 1956 5585 3673 3911 2335 2263 598 2260 3551 3908 56034 3696 3693 1385 3910 1946 3566 1942 9180 PMC12111946__F3 Research Progress in Medical Biomaterials for Bone Infections 613 7097 7099 5163 2475 PMC12112207__F5 Isochlorogenic Acid C Alleviates Allergic Asthma via Interactions Between Its Bioactive Form and the Gut Microbiome 246 239 1081 240 PMC12112211__F6 Activation of T cells by dendritic cells in lymph nodes; (B) binding of T cells to tumor cells inducing apoptosis; (C) signaling pathways for activation of cell growth and proliferation or signaling pathways for cycle arrest or apoptosis 7124 324 920 3717 6772 5728 7248 7249 841 842 4193 8772 834 835 941 355 PMC12112249__F2 MDK oncogenic signaling network 238 221914 4853 3845 3717 2475 4035 4691 6774 1499 4843 6385 PMC12112539__F1 IL-23 production and signaling pathway in the context of inflammatory bowel disease pathogenesis 3717 7297 6774 6775 149233 7099 130120 3554 114609 4615 51135 7189 3725 PMC12112539__F2 IL-23/IL-23R axis orchestrates innate and adaptive immune responses in the inflamed gut mucosa 3717 7297 6775 149233 324 PMC12112582__F4 Illustration shows the GPCR signaling pathway exploited by neuropeptides in insects to transmit signals regulating various physiological processes, including the mating behaviors 5624 64146 594857 PMC12112599__F7 Images of the protein processing in the endoplasmic reticulum pathways enriched among the imported differentially expressed genes (DEGs) identified from the lipopolysaccharide (LPS) vs 6396 7095 11231 4397 100187907 258010 55824 7353 581 22926 1998 7466 100506742 468 6402 6500 PMC12112630__F17 Overexpression of miR-454-3p leads to the inhibition of STAT3 and ATG12, which are involved in molecular pathways promoting Chondrosarcoma cell proliferation and evasion of apoptotic and autophagic mechanisms 9140 83734 10533 9474 6774 PMC12112713__F2 Notch signaling pathway 3714 182 10683 28514 54567 5045 65018 PMC12113536__F1 Aberrant pathways induced by SMARCB1 deficiency and corresponding therapeutic targets 6790 4609 3156 10873 1019 1021 2475 6598 65980 PMC12113536__F2 Summary of the role of SMARCB1 deficiency as a driver of the hallmarks of cancer in RTs 84868 3627 5551 283420 1956 PMC12113870__F2 Hesperidin action on the NFKB signaling pathway 1540 8717 6955 10487 10486 4513 23118 257397 90268 847 7498 4015 PMC12113985__F7 Novel Camel Milk-Derived Peptide LLPK Improves Glucose-Lipid Metabolism in db/db Mice via PPAR Signaling Pathway 1803 51 1962 PMC12114427__F2 Inducible expression pathway of Viperin 57506 3659 3661 3665 3454 3455 PMC12114667__F1 CK1E’s role in the Wnt/Beta-catenin signaling pathway 4609 1499 324 595 6615 6591 7447 332 PMC12114673__F9 Schematic diagram illustrating the mechanism of CCNB1 in melanoma cells resisting NK cell-mediated cytotoxicity 983 891 6774 100507436 4277 4087 4089 969 3458 PMC12114829__F1 Biosynthesis of BRs in plants 3010 4353 1356 5805 PMC12114876__F2 Medicinal Chemistry Strategies in Targeting TGFBR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR) 7048 7046 100187907 PMC12115143__F1 Integrative scheme of multistep phosphorelay in plants 5881 3258 6237 PMC12115344__F1 Diagrammatic overview of key pathways involved in ALD 355 6774 115004 114548 29110 3661 PMC12115679__F4 Critical signaling pathways regulating TILs infiltration, proliferation, and anti-tumor response 50943 6932 3579 2879 355 684 201633 3458 3627 PMC12115913__F1 SARS-CoV-2 infection pathways, spike protein domains, and main receptors 59272 8829 7097 7099 558 5045 6868 7113 PMC12115913__F4 The molecular mechanisms involving the interaction between the SARS-CoV-2 S protein and NRP1, DPP4, and CD147 cellular receptors 1803 8829 59272 4318 PMC12115990__F2 Biological functions of TRIM25 in SARS-CoV-2 infection and cancer cell survival 57506 7706 4193 9817 4094 10379 3665 3661 2879 7942 PMC12115990__F3 TRIM25 regulates the RIG-I- and MDA5-mediated antiviral and TRAF2/TNFA signaling pathways 1283 7706 201292 57506 7186 7187 7189 3661 7124 PMC12116171__F3 Up-regulated circadian rhythm pathway and phenological effects of cul4 mutant 1999 574414 80758 80742 PMC12116377__F2 Summary diagram illustrating PD-L1-related immune sensitivity and resistance mechanisms in GC 2638 960 50943 3242 920 PMC12116456__F3 VEGF-A/VEGFR2 axis drives HB pathogenesis via angiogenesis stimulation 7422 6714 2475 PMC12116488__F1 Molecular mechanisms of estrogen signaling in hepatocellular carcinoma (HCC) progression and immune modulation 619501 6774 9021 6778 3931 PMC12116488__F2 Testosterone-AR signaling pathway in HCC immunotherapy 367 11274 3458 619501 50943 2146 1499 PMC12116916__F8 TLR4 signaling modes and outcomes 7099 6850 5336 4118 4615 8737 29110 PMC12118952__F3 LDH in the occurrence and development of liver cancer 619501 3945 8205 PMC12119277__F2 Neutrophil apoptosis 4170 637 581 317 331 PMC12119277__F3 Mechanisms by which mediators of inflammation resolution regulate neutrophil apoptosis and survival 301 2358 2861 581 572 4170 317 59352 4353 PMC12119316__F3 CHMs and natural compounds suppress the progression of AS by inhibiting the activation of NLRP3 inflammasome 4615 51548 114548 23410 23411 PMC12119490__F2 Tumor-derived vesicles and induced signaling modulation in various immune cells 7852 468 3725 1843 7097 6387 10892 7099 6774 8205 PMC12119567__F4 Immune-metabolic crosstalk in HNSCC: mechanisms and therapeutic opportunities 6646 2475 8864 920 PMC12119701__F8 Possible mechanism underlying KCTD1-enhanced HCC progression 2475 284252 619501 PMC12120097__F11 Exploration of the mechanism of Polyphyllin I against hepatocellular carcinoma based on network pharmacology, molecular docking and experimental validation 4041 4040 7424 324 2444 572 PMC12120737__F5 PCSK9 activated the EGFR/HER3 signaling pathway in TNBC cells 255738 1956 6714 896 3949 2597 PMC12120866__F6 Critical gene network analysis of the up-regulated DEGs in the M 11130 3976 1058 7852 6348 4049 6364 2920 2919 6351 4712 4711 7381 9377 4707 4710 7388 4717 338 5340 2244 3263 197 350 2638 3273 653604 8350 317772 2243 462 PMC12121061__F8 Schematic model illustrating the mechanism of combined treatment of VEN and C-82 1499 836 1687 PMC12121119__F3 Bridging role of hepatokines in AD and metabolic disorders 26291 152831 27329 4087 4088 1385 6462 6414 3458 4035 2879 7099 7873 PMC12121617__F7 BNC1 acts on the CCL20 promoter to suppress the expression of CCL20 in GC cells 6364 1235 646 6774 3717 581 PMC12121766__F2 Sites of activity of genes encoded by SNPs observed to be associated in our study in the NO signaling pathway downstream of Cit 55170 4842 27345 5152 114 PMC12121814__F10 Multifaceted roles of the small EV proteome in NP cell and tissue homeostasis 7086 226 230 3945 PMC12121910__F4 Integrative analysis of metabolomics and transcriptomics revealing activation of lignin biosynthesis pathway in rice infected by Pst 3240 1312 790 57716 PMC12121985__F2 EGR transcription factors are essential in the functional regulation of T cells 27040 1959 1960 4665 1958 2885 PMC12122306__F1 Insulin signaling pathway in cardiovascular changes in GDM 8660 3667 2475 PMC12122316__F3 Major apoptosis signaling pathways participate in RA (by Figdraw) 7186 7124 8717 8772 1540 1499 572 23118 27429 2021 5879 51701 331 842 836 607 545 472 3725 PMC12122316__F4 LncRNAs play a ceRNA regulatory role in RA (by Figdraw) 100500847 5166 1290 57758 56999 102659353 1869 7503 100302148 442910 7528 51548 7099 100316868 842 355 581 836 9759 255082 100124700 54084 PMC12122448__F2 Biological processes and genes involved in the Apelin Adipocyte Signaling Pathway, significantly activated by the DOP diet 3091 8862 2767 3991 PMC12122839__F2 Generation and metabolism of sulfur-containing biomolecules 1610 4397 4524 635 875 191 6007 7263 2475 PMC12122839__F3 Sulfide signaling pathway 387 4087 100188776 4088 7248 7249 4089 6009 324 9817 1499 PMC12123091__F3 Metabolic pathway of hydroxyproline as an initial product for intracellular interconversions and processes 5625 58510 183 2875 PMC12123091__F4 Key metabolic pathways of proline and hydroxyproline in the cell 29920 4942 5625 2746 171425 183 1610 PMC12123228__F1 BCR signaling pathway and mechanism of action of BTKi 613 930 4067 6850 29760 695 5336 2475 PMC12123228__F2 Proposed mechanisms of BTKi-induced hypertension 4851 695 387 958 PMC12123823__F1 Mechanisms underlying NET formation 4353 11035 197259 79792 1019 1021 PMC12124620__F4 A) The role of notch signaling pathway in the aging of MSCs 182 3280 595 PMC12124646__F3 Schematic of the mechanism of NMs-mediated SCs in PNR 129521 2475 6774 4155 2668 627 5879 5376 4099 PMC12124646__F5 Mechanisms mediated by NMs that influence macrophage functionality in PNR 129521 2475 383 4360 PMC12124647__F4 Abnormalities in EPC Phenotype and Vascular Barriers in RA Synovium 10563 643 7412 PMC12124647__F6 Impact of Glycolysis in RA Angiogenesis 5209 387 2147 PMC12124647__F7 Relationship between Oxidative Stress and Angiogenesis in RA 7498 4967 115004 7124 4353 PMC12124647__F8 Angiogenesis in rheumatoid Arthritis: Pathological characterization, pathogenic mechanisms, and nano-targeted therapeutic strategies 7422 6714 8877 2475 PMC12124685__F11 HIV-1 infection stages, deregulated miRNAs, targeted hub genes, and principal enriched signaling pathways in macrophages 100126297 920 2475 PMC12124727__F3 Metabolomic analysis in QFA of WT, db/db and Mpst−/− mice 5091 4357 847 875 PMC12125403__F1 Transcriptional regulation of NLRP3 expression 7124 948 114548 196 2534 8772 10725 2475 1999 1432 PMC12125403__F4 Posttranslational modification of NLRP3 inflammasome components via ubiquitination and deubiquitination 10075 135892 84749 55223 8239 55072 9097 6502 55031 169834 7874 7621 11060 54790 139562 79184 114548 140609 11074 201292 7128 8805 3638 10617 5250 135644 7077 286827 56339 PMC12125588__F2 Ginsenoside Rg1 in protecting ischemic myocardium 7099 387 2950 4976 2475 65018 6647 114548 PMC12125588__F3 Ginsenoside Rg1 in modulating myocardial hypertrophy and fibrosis 846 23411 65018 5970 4318 4313 PMC12125784__F6 Working model 7249 4976 5245 11331 115209 PMC12125839__F2 Molecular mechanisms of mitochondrial damage involved in Parkinson's disease 581 4129 6622 PMC12125839__F5 Neurodegeneration models in Parkinson’s disease: cellular and molecular paths to neuron death 7942 2475 23400 3916 57192 120892 5071 65018 PMC12125911__F7 Schematic diagram of VWA1 and Rac2’s roles in condylar cartilage under mechanical stress 64856 2254 2261 176 596 4322 11096 5880 PMC12127168__F2 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways 7189 7186 4615 4703 PMC12127168__F3 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways 84133 324 1499 PMC12127168__F4 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways 2549 9846 3716 572 595 581 PMC12127168__F5 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways 6608 6469 5727 51684 64399 PMC12127168__F6 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways 3716 7297 3717 6773 2885 PMC12127168__F8 Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways 9817 4094 1728 PMC12127259__F2 Photo shows the signaling pathways in which each long non-coding factor interacts through different MIR signaling pathways (By Figdraw 55384 100124700 9021 1786 6473 6474 57575 PMC12127259__F3 Photo shows the signaling pathways in which each long non-coding factor interacts through different MIR signaling pathways (By Figdraw 100506119 283624 100616111 7431 7422 PMC12127259__F4 Photo shows the signaling pathways in which each long non-coding factor interacts through the Hedgehog signaling pathway (By Figdraw 5727 6608 642587 406988 PMC12127422__F9 Oxy-inflammation mechanism, Nrf2 and NFKB signaling pathway and regulation of the NLRP3 inflammasome 9817 114548 847 4513 3586 581 596 PMC12128263__F2 Three metabolic pathways in cells 2475 2744 2026 3939 PMC12128263__F4 Schematic diagram of cysteine metabolism 23657 6520 100188776 875 2879 PMC12128267__F9 Proposed mechanism of gastrointestinal exposure to SiO2 NPs induced AD-like neurotoxicity 594857 3065 8841 PMC12128433__F7 Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation 324 940 5335 969 3558 3458 PMC12128541__F8 Proposed mechanistic pathway for HDAC3 in mediating psoriasis 7124 8841 115004 PMC12128733__F8 Hypothetic molecular mechanisms and modes of the pharmacological action of adaptogen are updated from the authors’ free access publication [66] and authors’ drawings 1392 847 3569 7124 4513 PMC12128733__F9 Effect of Rhodiola extracts on the eicosanoid signaling pathway 246 239 100653365 4055 5739 PMC12128733__F14 Effect of Withania extracts in two doses on the eicosanoid signaling pathway 239 5737 246 2678 PMC12129893__F2 Sources of the microbiota and mechanisms by which bacteria regulate tumor progression 999 7099 1499 PMC12129981__F1 Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review 7124 115004 29110 3661 PMC12129981__F2 Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review 115004 29110 3661 114548 PMC12130087__F1 Canonical Wnt/Beta-catenin signaling pathway 4041 4040 1499 324 PMC12130335__F9 MAVS’ role in MIRI 23586 57506 7189 7188 596 581 PMC12130507__F4 KEGG pathway “Regulation of lipolysis”, significantly associated with CD36 abundance 7253 1311 390928 3630 3643 63924 5140 4852 4099 PMC12130507__F5 KEGG pathways “VEGF signaling pathway”, significantly associated with CD36 abundance 998 4513 572 PMC12130507__F6 KEGG pathways “Glutamatergic Synapse”, significantly associated with CD36 abundance 100188776 2717 1610 PMC12130703__F0 TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus 115004 6737 3661 PMC12130906__F2 Regulatory functions of the TGFB/Smad signaling pathway in the renal fibrosis 7124 10664 4087 4088 4092 4089 PMC12130998__F7 Supposed mechanism on the dual role of pB318L in viral replication 3454 3455 3716 7297 10379 6772 6773 3836 PMC12131027__F5 Schematic model illustrating potential pathways after PRRSV infection in PAMs with identified DEPs based on our study 3466 29110 3661 7098 4261 7187 6772 10379 7297 3716 23586 4939 4599 4600 3669 3434 9636 84174 567 5993 1385 4801 972 950 1508 5641 5066 PMC12131380__F7 Working model of this study 5617 5618 595 PMC12131388__F6 Drug-pathway-target-disease network of ATBC in ovarian damage (A) and infertility (B) 7124 4313 7099 472 6714 4790 2099 1432 596 4780 836 3558 5468 3845 598 5743 6772 3320 1508 3480 4170 3065 PMC12131435__F1 Various regulated cell death mechanisms—ferroptosis (1), cuproptosis (2), and necroptosis (3)—influence the tumor microenvironment (TME) by shaping immune cell populations and modulating tumor progression 324 920 56624 2879 PMC12131435__F2 Process of normal fibroblasts transforming into CAFs can be described as follows: a Growth Factor and cytokine stimulation 4089 4087 4092 857 8651 8703 3717 3482 4088 6774 2191 6497 2069 10413 90865 6714 PMC12131435__F8 Intricate signaling interactions between cancer-associated fibroblasts (CAFs) and cancer cells, highlighting key pathways involved in tumor progression, proliferation, migration, and metastasis 3082 5728 3481 6387 4838 6374 5163 650 2475 4087 4088 7412 960 2671 1956 6722 355 9235 10631 2069 PMC12131575__F6 Schematic diagram showing the possible mechanism of noise-induced cognitive decline 5163 6446 2309 604 PMC12131761__F1 Analysis flowchart 9961 4397 4284 PMC12131810__F5 Signaling pathways for axonal regeneration within neurons 9021 6774 10645 2475 2596 65018 57144 9751 PMC12132251__F4 Functional integrative gene-based enrichment for genes annotated to the meta-analyzed hypo- and hyper-methylated CpGs consistent across all three studies and across all LF phenotypes: GACRS, CAMP and VDAART 91663 5880 3861 126206 375449 147968 5091 80108 4353 574 199223 PMC12133496__F2 Simple signaling pathway map of SLC7 transporter protein changes affecting Beta-Cell Function and corresponding islet reactions 3667 7248 6009 PMC12133520__F2 Thymus cell development and regulation mechanism 2625 3398 4783 864 920 PMC12133554__F1 Molecular mechanisms of LGR4 in bone metabolism 55366 650 4772 284654 4041 1499 468 5163 PMC12133554__F2 Molecular mechanisms of LGR4 in tumor bone metastasis 1499 22943 4041 440400 55366 PMC12133565__F6 Loss of Hdac1 hyperactivates oncogenic transcription 122953 5155 10188 238 5159 5334 7422 777 775 776 57172 4843 107 5137 PMC12133616__F5 Stepwise presentation of the NF-kB signaling pathway 7124 23118 6188 PMC12133740__F1 Integrated schematic of glycolysis, mitochondrial metabolism, and lipid pathways in NSCLC cells 3939 3099 51660 1374 2194 PMC12133740__F3 Targetable metabolic pathways and inhibitors in NSCLC 1956 238 2475 4609 5209 5230 26227 29968 5723 3939 47 6319 2194 355 5009 383 445 435 6520 8140 8884 6510 PMC12133868__F3 Application and recent advances in conventional biomarkers for the prognosis of papillary thyroid carcinoma 673 4609 7015 2353 PMC12134342__F3 Tumor-associated neutrophil oncogenic mechanisms 6696 4353 6279 10447 3717 3667 6774 3383 6935 PMC12134342__F4 Tumor-associated neutrophil tumoricidal mechanisms 7226 4353 355 54814 2920 961 140885 3082 PMC12134342__F5 Interactions of tumor-associated neutrophils with other cells in the tumor immune microenvironment 384 2920 3554 6351 942 24145 920 PMC12134845__F1 EAAs are crucial for osteoblast function; their deficiency activates MAPK signaling, causing cell cycle arrest, ROS accumulation, DNA damage and apoptosis 4772 54407 5539 6510 9056 4609 PMC12134845__F2 Amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review) 2744 2475 3586 6774 196 6387 8841 PMC12134904__F5 IL-2 Action 5728 3716 3718 2475 50943 PMC12135143__S1 Biosynthetic pathway of IMP (Adapted with permission 140805 7808 5814 PMC12135226__F2 Lactylation 226 51203 3939 3945 54915 4361 2033 3146 PMC12135389__F1 CGAS-STING pathway and its cellular and disease functions 3454 3455 115004 29110 3661 7124 3716 7297 PMC12135473__F2 Dual roles of AIF in cell death and in vital mitochondrial functions 4282 131474 4725 PMC12136072__F2 Signaling pathway of BMP4 as well as activators and inhibitors of BMP4 cellular signaling 649 4091 4092 57154 64750 4089 25805 PMC12136072__F3 Recent Advances in the Delivery of Bone Morphogenetic Proteins for Targeting Glioma: An Updated Review 4851 4855 4853 4854 6469 6608 5727 4090 4086 2737 2736 6774 7128 648 100187907 PMC12136294__F4 Profiles of DEGs and DAMs in TCA cycle, insulin signaling pathway and Glycerophospholipid metabolism in response to diapause 4967 5091 1431 PMC12136530__F8 Proposed mechanism by which arginine inhibits tumor growth 790 435 445 5009 1373 PMC12137166__F1 CA PD-OTC of CZ019 displays enhanced glycolysis and noncanonical Krebs cycle metabolism 1641 5315 5009 718 6513 4199 4190 727 2744 2806 PMC12137631__F3 High fat diet disrupts Insulin signalling Pathway 5290 3667 3643 5295 5770 2539 PMC12137631__F4 Molecular mapping of HFD-induced liver inflammation and metabolic dysregulation HFD induced liver steatosis through activating key inflammatory and lipid metabolism genes 4023 9619 6720 6319 5468 3667 5290 3643 5295 58191 4790 7124 PMC12138068__F2 Phosphorylation and collagen-related diseases 780 4041 4040 84166 324 3661 2305 4092 4088 157310 3164 6774 6772 3553 7076 4087 27430 PMC12138068__F4 Ubiquitination, SUMOylation, methylation and collagen-related diseases 10206 4092 64750 2146 59343 3276 4088 2261 10419 1956 10196 PMC12138082__F2 Antiviral mechanism of miR-124, miR-24, and miR-744 5914 3150 6772 4149 4609 2002 2113 PMC12138082__F3 Mechanism of miR-342-5p regulating sterol metabolism 6772 3659 9619 19 51466 3156 3422 PMC12138082__F4 Proviral mechanisms of miRNAs 3716 3717 3569 7297 4615 6774 6772 6778 10379 57506 6387 3654 7189 7187 29110 10454 8767 139716 3659 407010 PMC12138082__F8 Vital role of the AMPK signaling pathway in cellular progress 10628 23216 5209 3172 7248 7249 2475 22863 1407 PMC12138372__F2 Cellular mechanisms of hormones and their effect on bone maintenance 249 860 650 50964 596 4772 PMC12139089__F3 Activation of transforming growth factor 1 (TGFB1) signalling in the development of DKD 7045 4087 4088 4089 6774 2475 PMC12139089__F5 Hippo signalling contributes to renal fibrosis and damage in diabetic conditions 4485 26524 9113 4151 4086 4089 PMC12139130__F1 Gut microbiota modulation in cancer metabolic reprogramming 572 2867 5970 8205 999 57103 6510 PMC12139130__F2 An overview of mechanisms of how gut microbiota increases the efficiency of immunotherapies 3665 115004 3458 285704 2475 5692 7099 54106 PMC12139502__F2 Proteome features of the four major heart cell-types 59 4619 8735 4624 4625 7134 4162 3691 2078 5175 1003 58494 1233 1496 1499 387 1500 3383 4846 2624 4843 7122 103910 445 435 5009 383 2697 6262 488 7448 8516 7148 22801 7139 1605 3339 PMC12139977__F6 Intersecting network analysis reveals interactions among genes involved in insulin secretion, cell cycle, and ER stress pathways 6616 1033 8091 2305 83903 347733 81610 6491 22974 203068 55215 8318 29128 6241 1063 90381 4605 9918 6502 83461 55165 2146 699 10615 259266 207 9319 10763 9133 51514 9055 8914 5347 890 991 10403 332 1062 9833 4001 146909 4171 157570 4000 50624 3727 10912 26232 10952 57405 7494 8714 3670 7101 3630 5062 2290 2888 54536 10955 257629 7275 4160 9699 PMC12140325__F8 KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration through Regulation of Wnt/B‐catenin signaling Pathway 4040 10661 6790 4288 1499 PMC12140338__S1 Potential mechanism by which viridicatol (VDC), derived from deep‐sea fungus, enhances osteoblastogenesis through modulation of the Wnt/SHN3 signaling pathway 1499 324 2932 860 249 121340 3381 632 PMC12141126__F2 Systemic lupus erythematosus-induced endothelial dysfunction and atherosclerosis 7450 1401 7412 3383 PMC12141490__F9 Neural controlled tear secretion from lacrimal gland 4025 4922 148 7351 PMC12142240__F7 Proposed pathway by which reduced SPDL1 expression leads to epithelial-mesenchymal transition and promotes cell migration and invasion in colorectal cancer 1950 1956 54908 999 PMC12143691__F2 Epigenetic modifications induced by gut microbiota promote inflammatory bowel disease (IBD) 4680 196 50943 3065 10014 55054 9474 8841 57721 114548 PMC12144116__F0 GAS6/AXL signaling promotes M2 microglia efferocytosis to alleviate neuroinflammation in sepsis-associated encephalopathy 558 5879 2621 6774 6667 PMC12144611__F3 Decoding CD24: Roles of chemoradiotherapy resistance and potential as therapeutic targets 100133941 6774 999 5728 9815 382 PMC12144634__F4 Cell cycle proteins: Linking the cell cycle to tumors 472 545 7465 5347 983 1017 PMC12144744__F1 Mechanism linking dyslipidaemia and gastric cancer 7412 6714 948 7424 2638 6369 6361 6367 3717 6774 8205 596 PMC12144744__F4 Antitumour mechanisms of statins 29110 3661 90865 6010 3156 3652 1499 2638 PMC12145212__F9 Mechanisms by which hypoxia impairs spermatogonial proliferation 1019 1021 595 PMC12145526__F2 The BMP pathway in the musculoskeletal system 4086 4089 9958 57154 54778 9759 4091 4092 10273 10987 4090 4734 4093 7375 8239 51592 2475 PMC12145526__F3 BMP signaling in OP 283120 861 860 468 8313 2487 22943 1277 117581 9242 6347 51129 182 PMC12145526__F7 Crosstalk of the BMP with other signaling pathways in musculoskeletal disorders (Created with BioRender 283120 4087 4088 4086 4090 4092 64750 4089 861 6662 9261 2932 324 1499 4091 PMC12145571__F2 Skeletal muscle atrophy is a multifactorial process that essentially results from a disturbance in the equilibrium between protein anabolism and catabolism 3479 4087 4088 4090 4086 4089 2475 8408 664 PMC12145652__F7 GETV Nsp2 inhibiting the RLR signalling pathway by regulating IRF3 activation 23586 57506 29110 3661 3840 3839 PMC12146001__F2 Introduction and optimization of lanosterol biosynthesis pathway in E 3652 4047 6608 7940 PMC12146007__F15 Bioactive components-modified smart implants for vascularization and osteogenesis 51564 84061 1284 860 PMC12146023__F2 Casein kinase 1 epsilon (CK1E) as a potential therapeutic target in chronic liver disease 4041 4040 1956 7187 324 1499 2932 29110 2737 2736 2194 PMC12146343__F1 Gut microbiota involved in the development of AIH 7099 196 2475 PMC12146543__F3 Integrative figure of molecular mechanism of traditional Chinese medicine (TCM) monomers-loaded exosomes for the treatment of neurodegenerative disease 2475 8678 9140 9474 4397 4280 351 581 PMC12146543__F4 Integrative figure of molecular mechanism of traditional Chinese medicine (TCM) monomers-loaded exosomes for the treatment of cerebral ischemia and reperfusion (CI/R) 581 6647 2876 2596 PMC12146603__F3 Neurotransmitter pathway affected by genetic 5‐HTT inactivation at PND8 2744 2572 2914 2893 PMC12149175__F0 Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway 1956 207 5295 5728 2475 1283 PMC12149389__F9 CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury 112616 3146 7099 4615 PMC12149821__F1 Representation of phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin sequential signaling pathway in breast cancer 5728 5163 2308 572 4193 595 PMC12150179__F2 Influence of ROS induced by microplastics on macrophage metabolism, function, and polarization 4843 2475 2879 472 8213 115004 11035 7037 114548 79792 6347 4513 958 942 948 9332 PMC12150179__F3 Microplastics indirectly affect macrophages by disrupting gut microbiota 7099 6347 4513 PMC12150400__F1 Three pathways of Trp metabolism in the human body 8564 8942 15 438 PMC12150400__F2 Bioactive effect of Trp metabolites in bone-related cells 196 4772 2309 4086 9242 55744 23411 5111 4089 1490 79923 6387 7852 57007 860 9507 15 2520 6662 PMC12150400__F3 Interaction between Trp metabolites and OA 6662 4322 50507 23411 4087 196 4513 4314 11096 PMC12150400__F4 Interaction between Trp metabolites and OP 4772 2859 406 7189 3276 196 860 23410 2475 6648 650 57154 4086 468 23411 7468 3082 5728 114548 PMC12150400__F6 Interaction between Trp metabolites and AS 1401 7124 3586 50943 6774 PMC12150572__F8 Role of CIP2A in OA cartilage 5966 57650 339855 57214 PMC12150590__F1 Mechanism of canonical Wnt pathway 4041 4040 1499 2932 324 PMC12150590__F2 Mechanism of non-canonical Wnt signaling pathways 324 1499 51701 998 387 3725 PMC12150590__F3 Wnt/Beta-catenin signaling pathway in cancer development and drug resistance 1499 324 10103 4286 2879 6671 7095 2305 23028 2048 1021 4814 4071 79589 284119 55163 7408 84617 2146 4041 4040 4282 7108 9124 861 1655 1045 64840 9712 1152 9739 51755 728 8205 79633 PMC12150590__F4 Therapeutic strategies of targeted drugs in Wnt/Beta-catenin signaling pathway 4041 4040 324 1499 64840 PMC12150590__F5 Timeline of clinical trials of drugs targeting Wnt/Beta-catenin signaling pathway 64840 22943 4041 PMC12150591__F2 Oxidative stress plays a dual role in CRC development 324 2932 1499 595 PMC12150591__F3 Differential regulation of oxidative stress and cell death by wild-type and mutant p53 1612 4193 2475 50507 7351 PMC12150591__F4 Oncogenic roles of KRAS and BRAF mutations in CRC development, malignant transformation, and metastasis 5170 27035 673 2729 PMC12151073__F2 Mechanisms by which lactate modulates the innate immune responses 4615 7189 7099 4513 PMC12151402__F1 Proposed effect of CHEK2 loss of function on cytotoxic T-cell recruitment at different organizational levels 11200 472 545 115004 3661 PMC12152130__F4 Relationship between cuproptosis and autophagy 1317 540 2242 2232 2230 1737 2475 8408 PMC12152351__F6 miR-1236-3p targets Toll-like receptor 4 to suppress the anti-Mycobacterium tuberculosis activity of macrophage 4615 7099 3569 7189 3606 7124 PMC12152576__F2 Contribution of type-I IFN-mediated neuroinflammation to Parkinson's disease progression 3661 115004 3454 3455 3716 7297 6772 6773 3665 10379 PMC12152632__F11 Proposed mechanism of TX's neuroprotection against Mn toxicity by upregulating REST expression via Wnt/Beta-catenin signaling in CAD neurons 89780 4041 4040 2852 5978 PMC12152662__F1 Regulation mechanism of PD-L1 in cellMultiple transcription factors directly modulate PD-L1 expression through distinct mechanisms 1950 3082 1956 3458 6772 693155 2475 673 5728 6774 3659 4609 3091 23476 PMC12152662__F2 PD-L1 in the ALK oncogenic signaling pathway in NSCLCThe EML4-ALK fusion protein enhances PD-L1 expression by activating downstream signaling pathways, including ERK, AKT, STAT3, and HIF-1A (24) 3845 2475 467 PMC12153268__F7 The mechanism of LAG3 inhibition of IFNG production by NK cells 3099 2475 4609 3902 6772 29968 3458 PMC12153588__F4 Microfilament signaling pathway 387 3985 3984 998 PMC12153588__F5 Microtubule dynamics regulated by interconnected pathways coordinating polymerization and depolymerization 387 1020 5347 891 PMC12153588__F6 PI3K-Akt pathway’s role in coordinating cytoskeletal dynamics during axon guidance by regulating microtubules, intermediate filaments, and actin networks 1399 2549 4134 5728 6009 2932 387 3985 3984 PMC12153588__F10 FGF downstream multiple signaling pathways 2885 387 4134 3985 3984 PMC12153709__F7 Graphical representation of the IL-4/IL-13 signaling pathway, including the genes described in Table 1 3597 3598 6774 6778 10344 3718 3716 7297 PMC12153738__F3 Progranulin (PGRN) in vascular pathophysiology 6272 1969 7099 7412 3383 4090 4086 PMC12153738__F4 PGRN’s multifaceted roles in lysosomal function, autophagy, and metabolism impacting cardiovascular health 7942 948 3569 9021 PMC12153797__F1 Exploration of the VE-cadherin structure and the transformations it undergoes when it comes into contact with VEGF-A 6714 1445 5747 PMC12153797__F2 Core signaling networks that contribute to the development of vasculogenic mimicry 472 6935 1017 PMC12153797__F3 Correlations of microbiome and different cancers 960 7099 6774 2530 PMC12153797__F4 Pathways in immune cells that short-chain fatty acids generated by GM triggers 7403 6659 6615 6935 960 100133941 PMC12153880__F1 The cGAS/STING pathway 115004 3661 29110 PMC12154018__F1 PI3K/Akt signaling pathway 1956 5728 5163 7249 7248 2475 64798 55615 64223 PMC12154018__F3 Inhibitors targeting the PI3K/Akt pathway, clinically approved for cancer treatment 5728 5163 7249 7248 1977 PMC12154116__F10 KEGG pathway maps enriched with downregulated differentially expressed genes (DEGs) in THP-1 cells following treatment with Biochanin A (100 μM) 546 1663 114799 25836 5885 9126 23383 10274 10735 23063 4089 4193 6502 9319 57082 699 9184 5111 1017 1022 90381 27085 8318 81620 1869 8317 1537 4661 999 8555 PMC12154233__F5 FSL-1 protects against radiation-induced damage through the TLR signaling pathway 7097 10333 7100 4615 51311 54106 PMC12154332__F1 Barrel-like structure of ABO forms ion channels in the cell membrane, allowing Ca2+ to enter the cell 6714 7019 23411 4899 PMC12154332__F2 Serotonin and BDNF initiate neurogenesis 627 5163 5164 1020 759 PMC12154347__F7 Dihydrocapsaicin Enhances Tumor Necrosis Factor-Alpha-Induced Apoptosis and G1 Cell Cycle Arrest in Human Cervical Cancer Cells Through TAK1-Mediated NFKB and EGFR Pathways 7124 1956 595 PMC12154365__F4 EBF1-mediated oncogenic mechanisms and regulatory network in BCa 116362 1879 284440 7025 PMC12154365__F6 Dual functions of EBF1 and its molecular regulatory network across multiple tumor types 100505641 9908 140828 23493 6657 1879 2200 101805492 PMC12154794__F3 Retinoids and fibrosis 7040 4087 4088 1969 PMC12154905__F3 Scheme of the identified TNF signaling pathway, with genes identified by changes in mRNA levels in NS1-treated human lung microvascular endothelial cells (HLMVECs) compared to untreated control cells 7124 914 790 355 3976 3569 7054 7128 7185 4323 4314 1540 83737 8772 836 64127 331 197259 7186 7187 6401 5076 3659 PMC12154924__F2 Recent Advances in Molecular Research and Treatment for Melanoma in Asian Populations 3815 2246 6098 2475 673 PMC12155190__F1 NFKB signalling pathway leading to the expression of genes encoding inducible nitric oxide synthase (iNOS), interleukin-6 and adhesion molecules (i 5970 3383 7412 PMC12155304__F4 Sinhyotaklisan as a Potential Therapeutic for Psoriasis: Network Pharmacology and Experimental Validation 6347 3309 2353 3458 3569 7157 6774 3553 213 3091 4780 1499 3552 5595 1950 5743 2099 3320 7124 5468 3725 5970 836 596 207 5465 3162 2064 595 4609 3383 1956 7040 4318 PMC12155351__F5 Δ-9-THC-dose-dependent pathways and associated genes found in disease-specific pathways 3099 7037 5214 7248 112399 5209 3717 2729 5230 2026 4524 2730 2512 112483 144348 22848 5565 5468 664 9554 11153 3725 51451 58515 27113 8878 23369 1195 6836 3934 2920 4792 2354 2919 PMC12155367__F8 HH signaling pathway functions in the E 6608 55582 1499 5111 1017 581 PMC12155444__F6 Composite Enzyme-Gene Network of Key Metabolites and Targets 7358 2592 7360 2582 9162 8526 55750 151531 1608 5338 8527 1890 8525 570 1607 100187761 100 4056 51056 2678 5970 7054 PMC12155930__F6 Anti-Inflammatory Activity of Thymol and Thymol-Rich Essential Oils: Mechanisms, Applications, and Recent Findings 387 6093 9475 29109 5728 7124 PMC12157585__F1 C. elegans fatty acid synthesis pathway and FAT-2 desaturase 2196 2195 120114 2717 79633 PMC12157604__F6 Neuropathic pain pathways of Glutamatergic neurons under Mor vs Sal (A) and Mor+Pro vs Mor (B) conditions 6863 627 2002 2353 4513 2582 PMC12157993__F10 TV-EV-induced inflammatory cascade in host cells 7098 114548 4277 10758 100379198 2919 PMC12158553__F1 Cellular heterogeneity between OA patients and non-OA controls 5624 3579 972 960 4282 7124 54360 9332 6387 2662 221044 PMC12158951__F1 Two main mechanisms of Fn promoting CRC proliferation 4041 4040 324 1499 999 7099 4615 607 PMC12158998__F5 Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and in vitro and in vivo experimental validation 2272 5915 51426 842 836 5728 1017 6502 4149 PMC12158998__F6 Molecular targets and mechanisms of cortex mori for lung cancer treatment: a network pharmacology study, molecular docking and in vitro and in vivo experimental validation 572 842 2022 1950 2064 51426 50808 5053 5979 2272 11186 PMC12160120__F1 CGAS-STING signaling pathway mechanism 115004 6786 3661 29110 PMC12160120__F2 Mechanisms and Roles of cGAS-STING Pathway in Regulating DC Subpopulations for Antitumor Immunity 5132 958 970 920 939 7054 1236 6351 6352 115004 3627 2829 4283 PMC12160120__F3 Mechanism and effects of the cGAS-STING pathway in regulating antitumor immunity across T cell subsets 29110 8320 55509 115004 11277 920 4843 2625 970 939 50943 3845 PMC12160120__F4 CGAS-STING pathway regulates TAM polarization and anti-tumor immune effect 619501 8205 115004 3661 6772 2920 7942 PMC12160120__F5 CGAS-STING interaction network with other immune cells and its regulatory role in tumor immunity 115004 29904 619501 4283 968 8651 6774 383 5091 PMC12160120__F6 Interactions and regulatory mechanisms between the cGAS-STING pathway and other components within the TIME 29110 3661 6772 619501 6774 4283 3627 PMC12160120__F7 Synergistic Mechanisms and Translational Potential of cGAS-STING Pathway Combined with Other Therapies 7124 3661 940 PMC12160515__F2 Possible signaling pathways in inflammatory-oxidative stress mediated neural regeneration 6648 9817 627 5728 572 PMC12162297__F1 Mechanisms by which a high-fat diet (HFD) affects hematopoietic stem cells (HSCs) 7046 4087 4088 7099 4851 PMC12162297__F2 High-fat diet (HFD) and energy-restricted diet modulate the function of hematopoietic stem cells (HSCs) 3479 23334 7248 PMC12162393__F9 Diagram of potential mechanism of TPX2 in HCC 619501 22974 2475 PMC12162639__F1 NLRP3 inflammasome signaling pathway 79792 4615 114548 PMC12162639__F2 Inflammatory regulation in the process of venous thrombosis formation 7018 7450 3383 7412 PMC12162925__F7 Integrating transcriptomics and metabolomics data 3156 341 55364 1071 7038 PMC12163303__F2 Mechanisms of translation regulation 2885 5163 7248 7249 6009 1938 29904 PMC12163381__F2 ILs exacerbating AKI progression 3717 7297 3383 3716 6774 6772 6775 PMC12163381__F3 ILs mitigating AKI progression 3560 3716 3718 6772 6778 6774 3598 55540 3717 7297 6775 PMC12163474__F14 Efficacy and Safety of Natural Apigenin Treatment for Alzheimer's Disease: Focus on In vivo Research Advancements 351 23621 3553 7124 6772 43 581 596 847 2670 23410 PMC12164274__F5 Mapping of transcriptomic data to the nonsmall cell lung cancer pathway 2272 842 1674 581 51426 3082 3718 5914 PMC12164340__F6 Alpha-Linolenic Acid from Zanthoxylum Seed Powder Regulates Fatty Acid Metabolism and Influences Meat Quality of Pekin Duck via the ADIPOQ/AMPK/CPT‑1 Pathway 9370 2171 948 4023 PMC12164393__F2 ICI myocarditis 6348 6352 6351 3627 6373 23452 7873 7054 PMC12164893__F1 Klotho protein-mediated network of signaling pathways 5196 8074 26291 9965 PMC12165590__F3 Applications of extracellular vesicles in osteoporosis 100302148 7874 6320 115908 84973 3939 51450 100616250 7422 PMC12165645__F1 Simplified overview of ISGs and their actions in kidney diseases 3434 9636 7006 100124696 4938 3669 PMC12165645__F2 Therapeutic agents targeting ISGs 3669 10379 9636 3661 3665 PMC12166595__F2 The Notch signalling pathway and conservation of its components across metazoan lineages 102 4734 5045 3065 342371 8650 100188776 PMC12167289__F1 Schematic summary of signal transduction mechanism of the canonical Wnt signaling in human cells 4041 4040 324 1499 2932 64840 607 PMC12167312__F1 Developmental neurotoxicity induced by anesthetics targeting GABAARs 627 7099 2475 4615 7189 571 581 637 PMC12167312__F2 Effects of anesthetics targeting GABAARs on different neuronal populations 7124 8682 627 PMC12167312__F3 Neuroprotective mechanisms of NAS 2852 114609 51284 7097 7099 4615 7189 581 PMC12167820__F2 Transcriptome analysis of S 2821 2597 5096 1431 2271 1611 PMC12170582__F3 This figure reveals important factors in anti-inflammatory signaling pathway of Rut in the CNS microenvironment 7099 114548 4513 942 383 PMC12170582__F5 This figure illustrates the diverse neuroprotective effects of Rut and its underlying molecular mechanisms 7099 761 627 4803 2668 23621 351 PMC12170596__F2 Microbiota increases host cell genomic damage and suppresses genome repair 7099 4615 4292 100423029 4436 2956 4437 PMC12170596__F3 Microbiota dysbiosis alters gastric epithelial cell signaling pathways 55054 1499 5734 6667 2539 115004 10562 8549 106480431 1045 8607 PMC12170596__F4 Microbiota shapes the suppressive immune microenvironment 7097 7099 114548 8205 54106 2638 6774 3661 PMC12170767__F4 Process Diagram 1431 207 149954 260431 PMC12170841__F1 Action of sEVs in promoting SC regeneration after SCI: (1) The sEVs alleviate symptoms by modulating the neuroinflammatory response to SCI 3565 3586 975 928 967 7251 10211 2668 4803 627 1270 PMC12170861__F4 Distribution of common targets in the main signaling pathways 1644 1610 64781 5350 1103 613 3270 10345 5266 90550 3371 PMC12170998__F2 Development of Traditional Chinese Medicine in combination with EGFR Inhibitors against Cancer 1956 5728 2475 PMC12170998__F3 Molecular pathways related to EGFR-TKI resistance 558 1956 3480 5728 2475 PMC12171307__F1 EMT and Tumors 6935 999 6714 5396 1956 672 3717 10000 6774 7422 PMC12171307__F3 Common regular pathways of ncRNAs 4602 100133985 3037 1382 100188953 100422829 1870 728192 23043 4089 999 1000 10000 6362 23493 693184 286002 1017 1499 64840 8323 4040 6590 4087 4088 4086 4090 5696 2475 60529 6387 56288 5728 6774 3717 693215 494514 PMC12172487__F1 Metabolic pathway of Sia and EV-D usage 84620 6480 54187 51083 10020 6487 6483 8869 6484 6482 10402 55907 10559 PMC12172856__F7 Interaction network of key signaling pathway-mRNA-miRNA 4214 6195 998 3667 5924 9839 9518 658 652 93 6615 10468 PMC12174016__F1 Molecular mechanism of pyroptosis 58484 114548 9447 22861 PMC12174016__F2 Mechanism of therapeutic strategies targeting pyroptosis for AD 114548 7099 10628 4094 79792 PMC12174428__F1 IFN signaling in beta-cells and autoreactive T-cells (inset) via JAK/STAT pathway in T1D 163702 3459 3460 3716 3718 7297 3717 6773 6772 10379 3133 467 7494 3627 PMC12174442__F4 CO2-fixation metabolic pathways in autotrophic microorganisms 47 8634 2597 4524 PMC12174527__F2 Metabolic Pathway of RFC 1719 4522 4524 6470 6472 PMC12174671__F3 Simplified visualization of NAD+ production pathways 93100 349565 64802 23057 23475 10135 PMC12174687__F3 Nectin-4 signaling in normal and malignant cells 207 1000 6387 7852 201633 PMC12174911__F1 Cross-regulation of ferroptosis and immunogenic cell death in tumor microenvironment 2879 4353 3146 PMC12174911__F2 Comprehensive schematic diagram of cross-regulation of ferroptosis and immunogenic cell death 6772 23657 2182 PMC12174920__F4 Molecular mechanism of KGN induced Hippo/TAOK1 Signalling Pathway 60485 4485 55233 92597 PMC12174920__F6 Molecular representation of repressed (left), in absence of hh ligands and activated (right) KGN induced hh signalling pathway, in presence of hh ligands 6608 2735 2737 2736 3549 6469 50846 PMC12174920__F7 Molecular mechanism of KGN induced AMPK-SIRT1/Antioxidant signalling pathway 4089 4093 4090 4086 6662 6671 23411 847 PMC12174920__F8 Molecular mechanism of KGN induced JNK/RUNX-1 signalling pathway 1499 6662 861 860 4322 PMC12174925__F3 Dual Role of Autophagy in Periodontal Tissue under Periodontal Pathogen Infection and Diabetes Environment 3082 527 2475 9140 3553 PMC12175327__F1 Neutrophils interact with CTCs through both direct and indirect mechanisms 100187907 7412 3383 961 140885 2919 PMC12175327__F4 Nanomaterials for driving neutrophil repolarization toward the N1 phenotype, degrading ENTs and modulating neutrophil infiltration 4318 594857 115004 8161 3661 4050 PMC12175451__F1 Circadian clock entrainment pathways 406 4862 9575 8864 1407 1408 6095 PMC12175451__F2 Related signaling pathway 1407 6774 79923 7097 7099 1647 4193 9575 406 5187 PMC12176010__F1 Research progress on the regulation of autophagy in cardiovascular diseases by chemokines 7248 7249 7157 6009 64798 64223 9706 8408 PMC12176239__F1 RA signaling pathway regulates the dynamic balance of differentiation and proliferation in LECs 5947 64220 9227 1592 2171 PMC12176563__F3 Multimodal regulation of cardiac metabolic flux and enzymatic hierarchy 2539 8473 948 5465 6566 622 PMC12176563__F4 Metabolic-targeted therapeutic interventions for cardiac functional recovery 55364 1803 23411 2695 718 PMC12176804__F5 IL-17 signaling pathway was enriched in the BD vs 6347 6354 6364 3569 4513 6278 6280 6279 6281 4312 4314 4318 4322 PMC12176845__F3 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) 4053 693143 4087 4088 7189 4089 PMC12176845__F4 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) 5728 693222 2475 693164 7422 3927 PMC12176845__F5 CircRNA: the potential biomarkers and therapeutic targets in oral squamous cell carcinoma (OSCC) 100302167 3717 2549 3976 6774 100188847 PMC12177077__F5 MBD2 in autoimmune diseases 8932 6772 1786 3430 53615 PMC12178005__F3 ECM remodeling facilitates the formation of immunosuppressive TME 4921 6678 4513 6387 7852 780 1236 7099 PMC12178005__F4 Signaling pathways of diverse types of collagen affecting tumor progression by regulating tumor immunity 6662 6374 920 7019 780 3903 3904 6772 1281 PMC12178005__F5 Signal ways of diverse types of HA affecting tumor progression by regulating tumor immunity 7097 960 4088 1499 920 PMC12178017__F6 EGb761 suppressed vascular dementia via modulating Wnt/Beta-catenin signaling pathway-induced apoptosis and autophagy in hippocampal neuronal cells 22943 345611 3916 8878 7942 PMC12178073__F4 Regulatory role of DEAD/H box helicases in the toll like receptor (TLR) signaling pathway 51311 51284 4615 170506 7189 54106 7096 10333 7099 3654 51135 6280 7098 9188 1653 7187 9416 29110 3661 57062 3665 4790 5970 PMC12179084__F2 Key signalling pathways implicated in macrocephalic ASD 2475 4763 5728 5163 7248 7249 6009 57680 1499 PMC12179417__F5 Endoplasmic reticulum stress affects the function of dendritic cells and T cells, leading to immune evasion 7494 468 30001 PMC12179417__F4 Endoplasmic reticulum stress on antigen–MHC‐I complex and natural killer cells 442911 468 7494 1869 100507436 PMC12179417__F6 Endoplasmic reticulum stress promotes the immunosuppressive activity of M2 macrophages and myeloid‐derived suppressor cells to enhance tumor immune escape 468 961 140885 383 4843 7494 22926 6774 6778 PMC12179559__F3 Energy metabolism and signalling pathways involved in IMPDH2 3615 7189 55215 2308 2475 2932 324 1499 4318 4313 595 PMC12179639__F1 Scientific diagram illustrating the mechanism of FGFR1 signaling, showing key pathways like PI3K-Akt-mTOR and RAS-RAF-MEK-MAPK for cell survival and proliferation 2260 5728 2353 3725 2475 PMC12179639__F2 Interactions between the PD-1/programmed death-ligand 1 (PD-L1), fibroblast growth factor receptor 1 (FGFR1) pathways, and chemokines 3458 3002 2260 6376 2247 4734 3627 PMC12179876__F1 Action and potential therapeutic targets of TGF-Beta-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension 4087 4088 4089 387 PMC12179905__F1 Pathways of apoptosis 7124 355 637 581 468 PMC12179905__F2 Common signaling pathways affecting apoptosis: Phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway and wnt/Beta-catenin signaling pathway 1499 324 2932 581 2475 PMC12179907__F2 Epigenetic modification mechanisms in congenital scoliosis 3500 64759 23199 23522 3507 57674 3502 7248 7249 1277 6092 57537 1289 2894 8074 5998 2932 1499 324 860 4920 6009 5728 6714 5879 387 PMC12179916__F5 Myosin heavy chain 9 activates the Wnt/Beta-catenin signaling pathway to enhance the proliferation and survival of cancer cells 4627 1499 4827 PMC12180163__F13 Pathways of action of ESPs intervention to alleviate UC in mice 64806 90865 1950 7473 7124 4583 PMC12180219__S1 Bionic bearing-inspired lubricating microspheres characterized by immunomodulatory for osteoarthritis treatment 4318 176 6662 5340 7124 4314 4322 9507 PMC12180341__F9 Potential mechanism by which PTS alleviates renal fibrosis 5805 4087 4088 PMC12180913__F2 Cell migration and function during normal wound healing 3082 3146 6347 9961 PMC12180913__F4 Rho GTPase signaling pathway in cell migration 6010 998 5879 PMC12180913__F5 PI3K/Akt signaling pathway in cell migration 5728 5879 998 PMC12180913__F6 TGFB/Smad signaling pathway in cell migration 4087 4088 4089 4314 1000 4318 999 387 PMC12180913__F7 Wnt/Beta-catenin signaling pathway in cell migration 4041 4040 1499 324 999 4316 4313 4318 1000 5879 PMC12181099__F1 Interactive effects of MSC and AML cells on each other 9242 3216 3200 581 637 960 1493 941 6387 2919 894 56339 283120 PMC12181166__F4 mTORC1 signaling pathway showing genes (or rather their gene products) that reached exome-wide significance in black 2309 7248 7249 6009 23387 64798 2475 64223 8408 6194 201163 57600 PMC12181760__F3 Pathways linking gut‐derived metabolite TMAO to CVDs via endothelial, cardiac fibroblast and cardiomyocytes dysfunction 114548 3553 7412 23410 23411 4088 4087 4089 PMC12182054__F1 FGF19-FGFR4-KLB signaling pathway 9965 2264 152831 2549 10818 2885 5163 1499 PMC12182306__F12 Scheme highlighting the main findings of the study 196 26291 6376 PMC12182320__F1 Expression profile analysis of key genes in the GSL biosynthesis pathway in B42OE, B42WT, and B42CR 660 51083 7054 PMC12183059__F1 Molecular mechanisms of ferroptosis 100 2182 10162 4015 55240 3162 23657 7874 6520 2729 7417 7419 2936 2879 3652 9817 6303 246 PMC12183064__F6 Molecular mechanism of ERA36-mediated protection against HG-induced apoptosis and senescence 2146 5728 581 836 PMC12183286__F2 TREM2 signaling pathway (by Figdraw) 5091 7099 4615 3937 7409 2885 6655 27040 7462 54209 6714 79930 6654 7410 10451 23607 79890 6868 102 274 6850 5879 998 1499 8528 PMC12183287__F2 BAs contribute to host metabolism in various organs through FXR and TGR5 2264 1581 9965 8213 7350 2194 5697 29881 64240 6366 1593 PMC12183292__F3 Molecular activity of platelet-regulated T cell immune response in acquired aplastic anemia (AA) 2833 643 7019 920 3002 3458 PMC12183848__F10 Photobiomodulation mitigates blood–brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway 4827 351 4035 581 PMC12184675__F2 Molecular mechanisms of SARS-CoV-2-induced pulmonary injury via apoptotic pathways 8717 8772 7186 581 PMC12184675__F3 CGAS-STING signaling pathway in immune responses to SARS-CoV-2 and DNA 115004 3661 3665 7124 PMC12184675__F4 Depiction of the innate immune signalling pathway, focusing on RIG-I/MDA-5/MAVS and their inhibition by SARS-CoV-2 proteins 7098 57506 7297 3716 7187 4615 6773 7189 6772 9868 3654 51135 23118 10454 29110 10379 3665 3661 7124 PMC12185281__F3 Pathophysiological mechanisms of insulin resistance in the vasculature 3630 5163 5164 PMC12185286__F2 Mechanism of BMSCs transplantation on neural plasticity 7124 627 1270 2668 4803 PMC12185430__F1 Mechanistic framework of the “multiple-hit” hypothesis in MASLD progression The pathogenesis of MASLD involves sequential pathological hits driving progression from hepatic steatosis to end-stage liver injury 7038 3569 7124 7099 8213 PMC12185430__F2 Gut microbiota-derived metabolites in MASLD pathogenesis under dysbiosis 8213 7099 3929 1571 929 2475 9965 196 PMC12185430__F3 Botanical drugs-mediated immunomodulation through LPS/TLR4 signaling 7099 4615 7124 PMC12185661__F3 GPER signaling pathways 7018 1839 1956 PMC12185702__F2 Mapping of the multi-omics MAPK/OIS/SASP axis in pLGG cells 4783 2113 4205 4773 2353 3726 467 7490 3170 4656 1051 4609 4790 5970 2624 3725 3091 6942 7975 6908 23028 1869 6667 10320 7157 2309 1386 1874 3054 861 4851 2919 3716 54583 10133 5371 3064 119 4303 7753 4314 4015 597 6647 5934 5580 1029 408 1432 673 6733 545 572 5595 65108 472 983 7150 3833 3065 6790 815 2596 1019 5166 79180 10606 3925 5347 9261 3667 4082 602 3838 5771 8289 4171 9212 2932 2673 PMC12185702__F6 MAPK/OIS/SASP axis in pLGG cells 3667 1019 1021 1017 3569 3553 5328 4312 5460 545 472 6647 84565 9212 2673 2932 5347 PMC12185857__F3 Fructose promotes systemic chronic inflammation 7099 7124 10628 114548 3383 PMC12185963__F10 TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway 7098 7189 23118 257397 PMC12186155__F1 Proposed mechanism of schaftoside anti-inflammation effects through the NFKB signaling pathway in LPS-induced inflammation on RAW 264 7099 4513 3569 PMC12187357__F1 Microenvironment drivers of the EMT 9839 6935 3091 7124 6352 6362 PMC12187357__F3 NFKB causes EMT-induced drug resistance 4851 7124 999 6935 9839 7291 PMC12187357__F4 miRNAs cause EMT-induced drug resistance 6387 5640 7852 5728 999 2033 1499 324 PMC12187357__F5 Signaling pathways responsible for EMT-induced drug resistance in HCC 1956 1950 4087 1499 4088 4089 3265 2475 999 PMC12187747__F2 ROS-induced cellular signalling in cancer cells 5728 572 581 6714 5163 2950 140809 PMC12187804__F2 TANs promoting the growth, proliferation and metastasis of breast cancer 7099 240 3934 4318 7422 389421 1075 PMC12187936__F3 Anti- and pro-tumoral immunity regulated by tumor-resident bacteria 3458 1116 8205 383 4353 PMC12188105__F1 Glutamine signaling pathway and metabolism in cancer 23657 3845 2744 2806 84706 2746 3417 7942 4609 PMC12188105__F2 LncRNAs regulate glutamine metabolism in cancer 100507475 3091 652995 101805488 2744 100316868 468 100124700 55000 PMC12188105__F4 Targeting glutamine metabolic reprogramming in cancers 8140 6510 11254 23657 81539 54583 3845 728655 100124700 2475 4609 84706 2806 23409 3418 2309 2752 5471 1956 PMC12188246__F7 Evaluation of the WNT signaling pathway components in an expanded BMP-SOX9-WNT Turing network 650 6662 6423 23213 PMC12188374__F1 (1) The EML4-ALK fusion protein produced by ALK rearrangement can activate the JAK-STAT signaling pathway 238 3845 54790 6774 4609 2001 7716 9839 7080 3170 3169 6657 6374 2921 2305 PMC12188374__F2 (1) Treatment with EGFR-TKI or KRAS inhibitors may lead to AST 6774 3853 6374 2921 PMC12188669__F5 Roles of YOD1 in Diseases 83737 55432 4734 5371 7528 64127 3623 8767 4193 619501 4627 PMC12188669__F6 Disease signaling by YOD1: potential implications for therapeutic strategies 55000 114548 1499 55432 983 51592 83737 PMC12188669__F2 YOD1 in regulating multiple cellular signaling pathways 83737 55432 4734 7189 4087 4088 PMC12189131__F2 Metabolic effects of hydroxybenzoic acid derivatives on the coenzyme Q biosynthesis pathway 23590 57107 56997 79934 51805 57017 10229 51004 84274 27235 PMC12189591__F2 Biosynthesis pathway of SFA and MUFA with graph data of fatty acid composition in the plasma of the control and atherosclerosis (AS) group 79071 64834 9415 60481 3992 PMC12189910__F8 Schematic figure depicting the potential role of LPS on endometrial receptivity in sheep 3690 3693 3976 7099 PMC12190578__F2 Simplified schematic of PpIX synthesis in heme biosynthetic pathway 5498 9429 1371 10058 PMC12190641__F1 Study flowchart 262 9517 3321 PMC12190794__F1 NcRNAs involved in the regulation of DIC 257000 407004 347689 6023 29092 PMC12190939__F2 Roles of DDR1 in tumor immunology 780 6374 6850 PMC12191077__F1 Proton-sensing GPCR-related signaling pathway 8111 2828 29933 8477 6010 PMC12191222__F2 Top2b-regulated gene, Bbs7, is an essential protein for BBSome-mediated ciliary trafficking 7155 117177 54585 PMC12191222__F3 Top2b-regulated gene, Ubb, is a key player in protein degradation and transcriptional regulation in the retina 7155 7316 7314 PMC12191222__F4 Top2b-regulated gene, Rbp4, is crucial for retinoid transport and visual cycle 6120 7155 5950 PMC12191222__F5 Top2b-regulated gene, Cetn2, maintains photoreceptor ciliary structure and function 5347 7155 1070 1069 55812 PMC12191222__F6 Top2b-regulated gene, Pik3r1, represents a pivotal signaling cascade in photoreceptor cells 5728 5266 9110 7155 5295 PMC12191222__F7 Top2b-regulated gene, Crx, is a master regulator of photoreceptor development and maintenance 5158 7155 1406 10002 4901 5015 PMC12191391__F4 TR2/TR4-mediated regulatory pathway in heme biosynthesis 211 2623 212 PMC12191890__F5 Calcium signaling regulation in keratinocytes 846 7220 488 3725 2353 PMC12191890__F6 Signaling pathways regulating epidermal homeostasis 1950 3714 5728 4851 3725 472 545 7248 7249 6009 581 596 PMC12192441__F1 Signaling pathways of activins and other TGFB related ligands in adipocytes 9573 4087 4088 7018 92 93 659 4086 4090 4089 PMC12192587__F4 Muscle Fiber Phenotype Shifts in Response to ECM Coatings 948 4899 9759 34 1374 260431 PMC12192587__F5 Predicted Regulatory Networks Influencing Muscle Fiber Type Transition by ECM Coatings 780 207 2308 6714 4790 4654 4209 4208 PMC12192670__F1 Vitamin D metabolic activation and signaling pathways (by Figdraw) 1717 1628 1593 PMC12192670__F2 Mechanistic network of the pleiotropic regulatory effects of the vitamin D/VDR signaling pathway in the pathophysiological microenvironment of DFUs (by Figdraw) 7421 7442 4803 627 PMC12192919__F2 Myostatin-mediated muscle atrophy in SMA 2660 4087 4088 PMC12192923__F2 The cGAS-STING pathway in health and cancer therapy 115004 3661 29110 PMC12193433__F3 Schematic on HGF/C-Met signaling in mesenchymal cells, activating RAS-ERK, RAC1-JNK, PI3K-AKT, and STAT3 pathways to regulate cellular processes 3082 5879 126669 2549 2885 6774 2475 PMC12193713__F5 Relationship between key genes in the biosynthetic pathways of amino acids and their derivatives and the synthesis of metabolites 26227 29968 5723 9562 2597 1737 2875 5132 47 1431 6389 162417 4967 2752 95 7068 23743 5009 435 PMC12193766__F3 Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology 9817 4094 2729 847 PMC12195072__F4 In the kidney and parathyroid glands, FGF23 signaling requires the presence of FGFR (fibroblast growth factor receptor) and the coreceptor klotho 8074 2247 2264 5741 PMC12195631__F8 Regulatory mechanism of BB in the treatment of CAG 999 2475 1000 PMC12196518__F1 Mechanisms of LSEC defenestration and the role of defenestrated LSEC in liver fibrosis 10365 7124 4018 7412 23509 6774 6010 PMC12196557__F5 Interactive effects of prenatal Poly I:C exposure and antipsychotics on various signaling pathways and receptors in the dorsal raphe nuclei 2572 2571 7098 207 10000 1385 1499 PMC12197700__F1 Signal transduction in the SA signaling pathway 4881 6612 4883 PMC12197700__F2 Disruption of the SA signaling pathway by viral proteins 4881 6612 4883 717 PMC12197721__F2 Proteins encoded by multigene family genes (MGFs) involved in the type I IFNs signaling pathway 3454 3455 3716 7297 115004 57506 6772 6773 10379 29110 3661 3665 PMC12197781__F6 Effect of Ad14 miRNAs on the NFKB signaling pathway 2688 650 7292 1950 8600 7124 4803 4049 10673 958 608 114609 51567 3932 4615 8772 7189 7188 7186 7187 7535 7128 5336 7334 7335 23118 257397 84433 1326 841 10454 1147 8945 5970 29110 3066 3065 PMC12199311__F7 Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling 6774 84667 3717 595 PMC12199322__S1 Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway 3717 6774 3146 PMC12199384__F1 Core‐shell manganese phosphate nanomodulator enhances anti‐tumor immunotherapy via bidirectional reprogramming of the tumor microenvironment 960 3146 920 100 PMC12199726__F1 Molecular and cellular signaling of intestinal tuft cells in response to infections 64806 5336 29850 6689 1103 PMC12200665__F9 TPA-induced activation of a PKCD/RIPK4/IRF6 signaling pathway inducing lytic EBV reactivation and epithelial cell differentiation in EBV-infected NOKs 3664 54101 9314 PMC12202337__F3 The ERK signaling pathway in regulating remyelination 1270 4803 627 2668 PMC12202350__F11 The molecular mechanism underlying EM-2 inhibiting the proliferation of LC and BC cells 472 637 581 PMC12202659__F7 Representative molecular pathways of breast cancer induction by PCBs compound exposure 2475 5879 6850 613 930 951 5728 5934 572 4193 4149 7124 7186 7975 PMC12203236__F2 Targeting Molecular Pathways in Breast Cancer Using Plant-Derived Bioactive Compounds: A Comprehensive Review 6774 1956 5728 2475 6502 PMC12204001__F1 Molecular mechanisms of cGAS-STING pathway activation 115004 3661 29110 PMC12204001__F2 Anti-tumor role of cGAS-STING pathway 115004 5763 3627 6373 100507436 4277 942 940 PMC12204016__S1 Expression of exosome miR-30a-3p was up-regulated in the lead (Pb)-exposed group, suggesting that the abnormal expression of exosome miR-30a-3p derived from osteoclasts may be involved in the Pb-exposed group 7054 8517 79792 PMC12204025__F2 Canonical insulin signaling pathway 3643 3667 2932 PMC12205135__F5 Glia-neuron interplay drives central sensitization in cancer pain 6387 2919 7852 3579 PMC12205195__F14 Comprehensive Genomic and Immunohistochemical Profiling to Predict Prognosis and Recurrence in Fertility-Sparing Therapy Based on Progesterone for Endometrial Carcinoma 2475 8717 7186 9021 3952 3953 6774 5443 181 4852 5465 PMC12205195__F15 Comprehensive Genomic and Immunohistochemical Profiling to Predict Prognosis and Recurrence in Fertility-Sparing Therapy Based on Progesterone for Endometrial Carcinoma 1839 1956 3725 126669 2885 2353 2475 PMC12205216__F4 Natural products targeting TGF‐B pathway in treatment of colorectal cancer 4087 4088 4089 999 PMC12205216__F3 Natural products upregulating TGF‐B pathway in treatment of leukemia 4087 4088 4089 PMC12205216__F2 Natural products downregulating TGF‐B pathway in treatment of leukemia 4088 4087 4089 1869 1019 1025 595 993 PMC12205666__F8 SiNPs inducing pulmonary genotoxicity and malignant transformation via autophagy dysfunction 8878 9817 4193 165918 PMC12205714__F8 The potential protective mechanism of BJOE in irinotecan-induced delayed diarrhea mice 115004 3661 29110 PMC12205806__F1 Part 1: The process of HBV infection and replication in cells: (A) HBV enters the liver cell via fusion and endocytosis 25859 920 4026 1499 PMC12205809__F3 Pro-inflammatory cytokines (interleukins/ILs) play a role in aged/postmenopausal breast cancer women or animal model/senescence cells, as depicted in the illustration 5641 6772 115004 6774 22992 3717 PMC12205809__F4 Interleukin (IL)-10/11/tumor necrosis factor (TNF) and transforming growth factor (TGF) pro-inflammatory cytokines play a role in breast cancer in postmenopausal women and senescence cells, as shown in the illustration 6774 7124 3590 6667 6382 PMC12205809__F5 Stroma phenotype of catabolic tumor 3091 857 6774 6469 PMC12205809__F6 Pro-inflammatory C-X-C motif chemokines (CXCs) play a crucial role in the progression and development of breast cancer in aged patients, postmenopausal women, animal models, and senescent cells 10563 6373 2833 2919 6387 7852 4283 3627 3576 6659 158326 387 31 185 643 PMC12206236__F1 Defining quality of cancer is cell cycle dysregulation, which results in uncontrolled cell growth and tumor formation 1019 1021 1017 983 PMC12206628__F6 Signaling pathways of NK cell-mediated cytotoxicity and apoptosis 7057 3066 84868 3146 5196 57506 2534 5551 3002 3454 3455 8797 5781 3805 3802 3107 3133 5604 5058 5335 117584 6810 6789 2932 PMC12206634__F10 The diverse intestinal innate immune pathway responses induced by non-S INDEL and S INDEL PEDV strain in weaned (A) and suckling (B) piglets 114548 57506 7187 7186 7706 4599 103 9636 3665 4600 PMC12206656__F4 Copper is closely associated with various forms of PCD 11035 81030 114548 2879 1737 2242 2475 65018 79792 PMC12206661__F7 PI3K-AKT and Hippo pathways play important roles in the regulation of ovarian tumor cell proliferation and PD-L1 expression 26524 9113 27040 7462 5728 PMC12207060__F1 Diagrammatic representation of the melatonin synthesis pathway and melatonin receptor-mediated cell signaling 4543 1644 15 4544 PMC12207060__F3 Schematic representation illustrates the molecular mechanism regulating MTNR1A, NEAT1 and AANAT gene expression in renal TECs 4543 406 8864 5394 3191 5307 283131 9575 15 PMC12207208__F3 TREM2 activation and downstream signaling TREM2 binds to ligands such as AB, ApoE, HDL, and LDL, leading to its activation 54209 7305 6850 PMC12207805__F8 Proposed mechanism by which L-Phe promotes liver steatosis 664 2475 5465 PMC12208402__F12 Proposed RasV12 singling network leading to cell dissemination 6010 5879 999 4312 PMC12208858__F2 Intravascular release and mechanism of pH-responsive TwHF nanocarrier 7124 6774 7412 3384 PMC12209307__F9 Diagram of the mechanisms by which tricin fighting against KRAS-mutant NSCLC 6714 3726 2354 3458 PMC12209371__F1 Role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma 3082 346389 1499 6774 2475 PMC12209467__F2 BMPR2 and TGFB signaling pathways in PH 659 3159 857 3397 54103 1410 2272 3624 1687 4851 1311 5209 7124 3611 25942 6774 5214 4681 5111 2335 PMC12209467__F3 HIF signaling pathway and targeted therapy in PH 11186 7291 6347 5111 187 7852 6774 3383 23076 23054 3939 3099 11331 10135 6591 5175 6615 4088 688 7422 6761 90865 1871 384 581 10533 572 374 PMC12209467__F4 MAPK and PI3K/Akt signaling pathways in PH 2002 55107 2247 581 5111 8877 1958 1843 5053 5209 5728 659 652 2475 4090 4086 56339 PMC12209467__F5 NFKB and NLRP3 signaling pathways in PH 197358 846 83933 100302149 114548 6648 9493 115330 PMC12209467__F6 Notch and AMPK signaling pathways in PH 659 7124 6714 55000 2296 4851 4854 4853 6502 3280 54567 23411 2475 50507 2305 5053 PMC12209467__F7 Wnt signaling pathway and targeted therapy in PH 1499 7291 6925 1959 4041 4040 5111 581 8324 2335 998 4920 PMC12209467__F8 BMPR2 and TGFB crosstalk with other signaling pathways in PH 659 3146 7099 7124 654 1499 4086 4087 4854 6714 6772 4853 260431 7474 7481 8324 8325 2535 4088 3576 PMC12209467__F9 PI3K, NFKB and AMPK crosstalk with other signaling pathways in PH 54567 114548 2247 7189 5053 197358 PMC12209598__F4 Oxidative stress 1998 1977 30001 8408 9817 PMC12209598__F2 Redox regulation of metabolism and bioenergetics 6850 613 4353 9817 472 4282 2475 114548 8694 PMC12210125__F2 Signaling pathways for the polarization of TAMs towards the M1 phenotype 6850 116071 51441 25939 3428 54567 28514 3662 PMC12210125__F3 Tumor cell-macrophage interactions reprogram M2 TAM polarization 3566 6778 51441 4513 6774 6352 10643 1234 3976 6347 6850 2118 3577 3576 3091 6035 238 126353 6996 PMC12210160__F1 Anti-hepatitis B virus hepatic innate immunity in hepatocytes 7097 4118 4615 7098 57506 2146 7124 3553 3586 PMC12210305__F6 High-temperature stored soybean meal on MAPK and FOXO signaling pathways in broiler jejunum tissue 5624 4149 2316 3727 7124 2002 8717 100187907 4163 355 1616 4208 929 23118 51295 51701 1950 6955 4088 4089 1537 6502 4193 3630 5728 664 3276 472 1017 6774 10365 PMC12210318__F2 Complete RNM for the MAPK Cancer Cell Fate Network of Grieco et al 1956 2261 4609 4149 PMC12210502__F2 TSC1/2 signaling pathway (by Figdraw) 5163 5728 6009 7249 64223 253260 2475 64798 PMC12210502__F3 The molecular interactions and signaling pathways involved in the association between TSC and acute kidney injury development (by Figdraw) 7248 6009 2475 64798 PMC12210502__F4 The molecular interactions and signaling pathways involved in the association between TSC and renal fibrosis and CKD development (by Figdraw) 9242 7248 117854 7249 2475 64223 64798 PMC12210502__F5 The molecular interactions and signaling pathways involved in the association between TSC and diabetic kidney disease development (by Figdraw) 7248 7249 64223 2475 64798 PMC12210502__F6 The molecular interactions and signaling pathways involved in the association between TSC and renal cysts and polycystic kidney disease development (by Figdraw) 572 7248 5310 96459 PMC12210502__F7 The molecular interactions and signaling pathways involved in the association between TSC and renal cell carcinoma development (by Figdraw) 7249 10457 7030 7942 7248 PMC12210502__F8 The molecular interactions and signaling pathways involved in the association between TSC and renal angiomyolipomas development (by Figdraw) 7248 7249 4286 100187761 PMC12210502__F1 Patterns of TSC1/2 role in kidney disease (by Figdraw) 5310 96459 7249 7030 7942 4286 4193 6009 2299 PMC12210545__F3 Complement system and the role of HCQ 718 717 727 PMC12210561__F2 Gln modulates multiple signalling pathways to regulate cancer cell proliferation 54407 6510 440 2744 4485 1969 9113 1956 PMC12210716__F1 Jak-STAT signaling pathway 3454 3455 3460 3459 3716 7297 6773 6772 3717 10379 PMC12210724__F1 Association of SNPs in carbohydrate metabolism genes with insulin resistance indicators in the Mexican population 144195 6523 6513 155184 66035 56606 81031 6518 6515 11182 6514 6517 29988 6527 6524 200010 50651 25796 2539 5226 6888 6120 22934 7086 229 226 230 2023 2026 2027 2821 26330 5223 5224 5230 5232 2645 3098 3099 3101 5211 5214 2203 8789 5105 1737 2805 1738 2806 3945 92483 3939 4191 4190 3948 5160 5091 5161 5163 5162 8050 5166 5165 5164 57546 54704 50 3418 1431 2271 1743 4967 3421 3420 6390 6391 6392 6389 8801 8803 8802 PMC12210776__F4 Key mechanism diagram of the combination of JZOL and AZ in the treatment of MPP 840 7124 6364 4323 6401 5743 2919 4314 3383 PMC12210845__F6 Analysis of protein-protein interaction network of combined DEPs and DEPPs related to ABA signaling pathway under HS in nucleus (a) and in chloroplast (b) 100 7006 100124696 8533 6651 100188863 7808 PMC12211004__F7 Schematic diagram regarding key parts of this study 5008 9180 3977 PMC12211009__F10 BACE1-AS in the regulation of the propagation of C 100379571 3661 596 PMC12211383__F1 Sources and metabolic functions of serine 26227 29968 5723 6472 6470 PMC12211798__F7 Proposed model of IGF2BP3 joined in autophagy mediated TNBC metastasis with m6A-dependent molecular mechanisms 1982 3486 2475 PMC12212355__F2 Preventing T cell exhaustion and enhancing cytotoxicity through metabolic reprogramming 3586 3002 6932 10538 940 154 759 7535 10578 3164 5922 23411 PMC12213685__F12 HDH-SBH drug pair act on potential targets and mechanisms of action of PI3K/AKT signaling pathway 2475 1977 7248 6009 7249 2885 3667 5879 6850 613 930 11140 5728 5163 5934 572 4193 PMC12213698__F2 Basics of the noncanonical Wnt signaling pathway 4041 4040 324 1499 PMC12214129__F8 The effect of miR-1 loss on glycolytic and pentose phosphate enzymes and intermediates 2539 9563 5226 2821 226 2597 2023 5725 5166 9123 PMC12214337__F12 Comprehensive Computational Assessment of SNAI1 and SNAI2 in Gastric Cancer: Linking EMT, Tumor Microenvironment, and Survival Outcomes 6591 9672 4320 PMC12215033__F7 Schematic pathway illustrating the potential effect of curcumenol on Fc epsilon receptor I signaling 2534 4067 6850 9846 5163 695 PMC12215251__F1 Wnt/Ca2+ signaling pathway, created in BioRender 84876 6786 51701 998 1499 PMC12215448__F4 Interaction of CD8+ NKT-like cells, CD8+ T cells and GDT cells with NK cells 920 7124 3689 51744 962 7133 PMC12215756__F10 NCC cellular metabolism is coupled to a developmental program 7471 2744 5315 6615 6591 27022 PMC12216578__F4 Effect of PM2 2260 6010 27040 790 PMC12217143__F7 TgFLP12 function in Toxoplasma gondii lipid metabolism 6923 6924 6921 4018 PMC12217521__F6 The paracrine effects of Mac-ADSCs 5290 3569 3589 3082 7422 PMC12217801__F6 Proposed molecular mechanism by which PBM preserves erectile function in diabetic mice 4149 627 4803 2247 PMC12217889__F4 Crosstalk Between the C1 Subpopulation and EndoCs, ECs, and Macrophages 6387 57007 5764 4192 PMC12217925__F8 CDH17-mediated regulation of LGR5 expression, Wnt signaling and drug resistance 1015 8549 999 9429 92745 2048 1045 4609 PMC12218123__F1 Folate metabolic pathway; connection between the folate cycle and methionine cycle 4524 635 875 1491 PMC12218202__F6 Chlorophyll synthesis and degradation of tomato leaves in WT and slprr1 lines under SD or LD conditions 210 7390 7389 130749 4255 5447 27159 PMC12219042__F8 PKA-NFATs signaling pathway 7423 717 4773 4772 4656 4208 PMC12219279__F5 Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway 3488 3479 3480 3667 PMC12219554__F1 Schematic illustration 50964 6774 4827 PMC12219892__F10 Pathways associated with DOX-induced cardiotoxicity 3146 3569 23411 2475 PMC12219892__F2 Scheme of the study design and workflow for transcriptomic and metabolomic analyses 3624 6418 2669 PMC12220104__F2 Activation of the IL-11 autocrine loop: TGFB acts on the TGFB receptor on the cell membrane, phosphorylating Smad2/3 in the cytoplasm 2932 4087 4088 6774 2475 6364 6374 6372 2919 3590 2002 1386 1499 PMC12220111__F1 Modular engineering design for the compartmentalized synthesis of taxifolin in the peroxisomes of S 5539 2195 11113 PMC12220482__F2 Mechanism of NUSAP1 in cancer 51203 324 920 PMC12220693__F1 Normal tryptophan synthesis pathway 125061 8564 8942 15 438 23475 PMC12221917__F2 Signaling pathway induced by TNFR2 7186 7187 5971 4049 PMC12221920__F1 Two states of the Hippo pathway in the mammalian tumor microenvironment 4485 60485 9113 81532 PMC12221920__F3 Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration 8777 4016 4485 23513 26524 9113 4773 84962 PMC12221920__F4 Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration 3297 27122 4485 9113 81532 4092 7074 6714 4034 2475 PMC12222062__F8 Oxytropis falcata bunge extract combined with black soybean oil ameliorates DNCB-induced atopic dermatitis-like skin inflammation 3565 10850 10800 8841 PMC12222133__F3 Apoptosis in NPCs 8772 637 4170 331 317 581 PMC12222133__F6 PANoptosis in NPCs 81030 11035 8737 9447 841 114548 834 91662 839 8772 1687 197259 79792 836 PMC12222209__F3 Aberrant localization of glycolytic enzymes on cancer MDR 79923 2146 5111 2597 1956 5230 8317 1499 8841 5243 472 3939 283871 9429 3099 2023 54918 5214 10524 581 596 PMC12222324__F2 FOXM1 in ovarian cancer development 4089 1745 3852 3855 10112 899 5347 994 891 6502 2305 3099 1499 PMC12222324__F3 FOXM1 involved in chemoresistance in ovarian cancer 9156 2475 2305 6667 11004 PMC12222446__F1 Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias 4507 384 383 262 6723 6611 4942 54498 5625 2752 2744 6520 196743 6303 857 2817 PMC12222446__F5 Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias 4507 384 383 4144 262 196743 6723 6611 54498 6303 PMC12222815__F7 GCRSZXD- Chinese herb - active ingredient - hub gene - signaling pathway – disease network 207 1956 6714 2638 PMC12223711__F3 Function of NDR1 and other NHLs in PTI and ETI responses 2821 6187 578 PMC12223783__F11 Exogenous spermidine inhibits trastuzumab-induced cardiomyocyte pyroptosis Schematic illustration of trastuzumab-induced cardiomyocyte pyroptosis, and exogenous spermidine blocking the action of trastuzumab by promoting mitochondrial biosynthesis 7019 23410 79792 PMC12223915__F6 Serum Pharmacology Combined with Network Pharmacology Reveals the Effects and Mechanisms of Ganmai Dazao Decoction in the Treatment of Depression 7432 4852 5020 126669 10743 PMC12224056__F4 TRAIL‐mediated apoptosis pathway 8772 637 581 PMC12224056__F3 Schematic representations of the effects of iron chelation on CRC pathogenesis and progression 1499 324 472 545 4193 10397 6093 999 PMC12226124__F4 Association of the inflammasome cascade with AD immunopathology 9447 114548 22861 3606 79792 PMC12226309__F1 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products 115004 29110 3661 PMC12226309__F3 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products 196 340061 115004 PMC12226309__F4 cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products 581 3661 115004 114548 PMC12226585__F1 ADSCs/ADSCs-exosomes mediates a multidimensional network of mechanisms for IRI repair 1499 6774 3383 581 3082 5111 1728 4353 26291 PMC12227620__F8 Graphical representation of the working model 3579 1829 960 1499 6932 PMC12227979__F5 Exploring the Therapeutic Potential of Oxo berberine Compound in Arcangelisia flava Root Extract for Breast Cancer Treatment: Metabolite Profiling, Pharmacological Network Analysis, and In Silico and In Vitro Evaluation 2475 1977 7249 5447 5879 6850 613 930 5934 572 256933 PMC12228400__F11 Schematic diagram illustrating the antagonistic mechanism employed by ASFV MGF505-4R on IFN-I responses 115004 29110 3661 54472 7297 3716 6773 PMC12228841__F5 TLR2 and TLR4 signaling pathways and their interplay 7097 7096 4615 10333 3654 51135 7189 23118 257397 7099 PMC12229020__F1 ECM deposition-induced inflammation and fibrosis 23411 3725 4015 1325 114548 PMC12229020__F2 Impaired ECM degradation in PCOS 196 4015 468 581 596 4513 2638 PMC12229020__F3 Altered mechanical forces in ECM remodeling 5728 2309 2638 PMC12229362__F3 Phosphoinositide compartment 56623 7289 23432 PMC12229470__F6 Molecular mechanism by which AloAB suppresses HNSCC progression via inhibition of the STAT3/SLC7A11 signaling 6774 23657 847 2182 4025 1000 999 PMC12229552__F9 Schematic diagram illustrating the mechanism by which DDX1 lysine methylation mediates MATR3 alternative splicing to regulate IVDD 4199 1653 2146 9782 594857 PMC12229708__F7 Uterine stromal MEN1 regulates stromal decidualization and epithelial differentiation 22943 6423 10873 5617 9464 3484 PMC12230168__F7 Molecular mechanism of rosmarinic acid synergistically enhancing gefitinib efficacy in EGFR-mutant lung cancer by inhibiting cancer-stromal interactions and miR-21 signaling pathway 406991 27250 6935 999 2191 PMC12230486__F1 Under Hypoxic Conditions, The Energy Metabolism of Cardiomyocytes ChangesMany of the discussed pathways show protection against ischemia-reperfusion injury (IRI) (green arrows) or are protective if blocked (red arrows) 5079 10320 2539 5226 57103 4609 2147 3939 6472 3418 7295 5163 2271 56961 23409 2744 PMC12230486__F2 Metabolic Adaptations and Therapies in Cardiac Hypoxia 3091 5166 5465 7416 948 PMC12230486__F3 Metabolic Adaptations and Therapies in Cardiac Hypoxia 948 10461 7424 7422 91937 PMC12230486__F4 Metabolic Adaptations and Therapies in Cardiac Hypoxia 5079 57103 3099 5226 2147 4609 3939 6472 3418 2271 7295 56961 23409 2744 PMC12230579__F7 Network of compound-reaction-enzyme-gene 11313 220 218 224 5338 219 9388 5408 3991 3988 3990 55750 9162 10400 1103 1119 1120 54578 54658 4967 7366 7361 6389 1431 1738 3162 644 2875 84706 2744 4846 162417 2730 8659 26873 126133 2936 1384 PMC12230643__F4 Multi‐omics network of hyperglycemia‐induced vascular calcification 875 57085 2571 2572 84890 2805 51380 23043 2806 PMC12230849__F4 MiRNAs regulate the proliferation and migration of VSMCs 693222 3178 100507392 85028 283120 9817 554212 4208 407008 1499 PMC12230849__F6 Autophagy in VSMCs and its influencing factors 7942 64805 9474 1847 55102 22863 7442 283120 2475 PMC12231332__F3 Relationships between pro-inflammatory cytokines and bone signaling pathways affecting osteoblastogenesis and osteoclastogenesis 50964 3479 1499 4089 3553 1401 860 7189 4772 100187907 4318 PMC12232070__F12 Mechanism of RME inhibiting the secretion of inflammatory factors by regulating the Dvl1/Wnt1/Beta-catenin/GSK-3B signaling pathway in the treatment of RA 4041 4040 7471 1855 1499 324 PMC12232514__F3 Non‐caloric artificial sweeteners on gut health 7100 4615 4353 PMC12232702__F5 AKT phosphorylates USP4 7186 7189 4089 6009 10716 7375 PMC12232815__F8 Mechanism diagram of BYHWD 4967 10135 7019 PMC12232871__F5 Underlying mechanisms of several potential PC therapeutics via proteomic approaches 2475 4087 4318 4313 7039 6667 6469 3312 581 55075 205 335 3939 23657 PMC12232871__F7 Some KRAS signaling pathways mediating PC mentioned in this review 3845 5899 5898 1984 6714 1956 79834 2475 22934 4609 PMC12232871__F8 Some p53, CDKN2A, and SMAD4 signaling pathways mediating PC mentioned in this review 3845 1385 4087 1029 4088 4089 5230 1019 1021 3169 3190 PMC12234022__F3 Chemically modified ncRNAs in diseases 677809 79068 5820 4839 677835 2729 26765 692198 4827 441951 51602 57721 7503 6935 91746 1736 54517 4553 692204 4234 10785 54888 1072 64848 PMC12234474__F5 Targeted Therapeutic Strategies for PDAC 5209 2597 9938 2475 PMC12234736__F3 Sufu prevents sepsis by disrupting the LLPS of TRAF6 4615 7099 3654 51135 51684 7189 PMC12234736__F4 Phase separation is associated with cGAS-related inflammation 5094 115004 11277 10146 57506 29110 3665 3661 7706 PMC12234736__F5 LLPS regulates immune cell alterations during adaptive immunity 613 2885 27040 PMC12234771__F4 Comprehensive strain‐identification pathway for the seven UCYN‐A strains, established by the codon aversion motifs of the 40 genes 7068 22934 2821 5226 6120 23237 PMC12234872__F2 Cellular senescence and other age-related mechanisms in the pathogenesis of OP 2309 3953 6387 6660 7942 1789 1803 6696 5008 56339 100133941 25801 7040 1234 7474 7168 10533 84557 1493 PMC12234997__F5 Protein-protein interaction (PPI) network analysis related to IMP and IMF and identification of their major effect genes 5210 5236 10449 1376 5213 443 8789 57571 272 339896 122622 5315 2261 5880 5836 1282 33 5590 2027 4893 113 5144 4539 221 18 54539 217 1945 3908 8503 57678 60481 3694 112 4536 129642 4909 5520 818 4217 4707 4519 23236 4508 7422 207 7010 8473 4023 6262 1339 2593 4700 5530 1399 2309 842 9388 4193 284 3553 948 6446 604 3659 3625 1152 4512 4726 1158 4843 374659 2875 2584 875 901 8649 90865 3560 4283 6387 51554 84706 1284 90 9296 3575 6358 27345 PMC12235022__F6 Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation 596 4314 7098 5580 2475 3329 3164 3455 79924 942 929 3727 3304 7450 7010 3565 3725 2690 54106 50507 2212 1950 2056 7124 1910 939 919 5599 7249 1269 8360 7436 5196 100506742 581 8878 6387 2932 23643 2922 2335 1392 3605 2185 3122 5623 133 5979 1075 8862 3952 100187907 103 54822 5293 9759 3687 6351 348 1535 5595 1401 7317 3710 7431 1909 3577 5328 51135 285 2668 4609 7432 9447 4049 3684 2920 3371 2353 6850 7066 4193 6347 324 7421 79671 7015 1431 4170 1848 8743 1432 1508 7157 64127 6622 958 355 60 3579 386653 3479 10097 718 1387 57007 3559 488 5568 5468 960 551 8678 5970 6696 6262 915 64581 5781 3308 3717 9021 627 6774 257397 8651 5578 5032 6513 10533 409 972 9817 8322 885 1437 1154 695 1311 6750 27180 796 7535 4902 6401 1026 930 3661 29760 7099 356 10135 7097 5728 3162 3558 1673 572 3106 2033 1908 4210 842 6648 29949 5340 3683 6364 5443 9048 847 9927 5335 4360 1440 5741 810 5315 85480 4843 7852 2243 183 9235 177 3458 3606 7295 PMC12235022__F7 Investigating the Therapeutic Mechanisms of Honeysuckle (China) in Sepsis Through Network Pharmacology and Experimental Validation 7097 10333 54472 4615 8772 114609 3929 929 7099 958 941 942 7189 3665 1513 3661 7297 6773 PMC12235270__F2 Unraveling the Hippo pathway: YAP/TAZ as central players in cancer metastasis and drug resistance 60485 4485 26524 9113 10413 PMC12235416__F1 (Figure created using BioRender 6868 102 9794 PMC12236007__F7 Hypothesis schematic models illustrates that Myh3 regulates the development of porcine intramuscular preadipocytes through the p38 MAPK signaling pathway to affect IMF content 4621 94005 1017 1050 355 4023 3034 PMC12236747__F3 Indole metabolites induce neuroinflammation through the AHR and NTS pathways 196 7039 4922 3454 7423 2321 8835 627 PMC12236749__F2 BMSC-Exos ameliorate MI 5728 6647 7099 114548 664 9776 150209 10746 581 83737 284 170690 331 2146 8091 PMC12236749__F3 BMSC-Exos alleviate MIRI 2 356 331 79804 9927 7099 6774 51621 51547 2308 3479 6647 581 5728 23369 9588 254559 23657 8314 2182 PMC12236749__F4 BMSC-Exos improve AS 400550 9817 407020 7003 8091 5728 19 79792 114548 1051 PMC12236749__F5 BMSC-Exos ameliorate other CVDs 5879 9314 2308 7099 3146 114548 10642 64094 1499 PMC12236749__F6 Cardiovascular-derived exosomes regulate the bone 27123 1499 7976 406990 PMC12237497__F10 Working model of GPR120 modulation of mammary gland function 4280 7099 7189 948 7852 2194 31 9547 10664 PMC12237660__F2 Targeting TREM2 signal pathway 54209 102 6868 6850 PMC12237660__F3 TREM2/TREM2+macrophages in MASH 54209 7099 4615 6850 3654 7189 PMC12237979__F2 Necroptotic pathways 355 8717 7186 8772 9825 11035 7098 7099 81030 197259 PMC12238214__F5 HNF4A Downregulation Drives Hepatocellular Carcinoma Proliferation and Genomic Instability: Downregulation of HNF4A promotes HCC progression through key molecular pathways 3172 899 595 619501 PMC12238214__F6 Hepatocyte nuclear factor 4-Alpha: a key regulator in liver carcinogenesis 619501 3172 3569 PMC12238274__F1 Possible mechanisms by which ApoE4 affects AB production and clearance 4035 1020 54209 2475 3416 351 23621 PMC12238274__F2 Possible mechanisms by which ApoE4 affects tau phosphorylation and clearance 7018 4035 1020 5529 PMC12238274__F3 Possible mechanisms of ApoE4 in microglial immune activation 50507 3146 11025 7099 948 54209 4615 7186 2475 114548 7124 2744 PMC12238443__F2 Current model of the BR signaling pathway in Arabidopsis thaliana 578 51411 5243 10399 PMC12238593__F4 Genetic alterations driving glioblastoma pathogenesis 1956 3845 1029 4193 1017 1019 5925 2475 5728 1869 5163 472 545 991 6657 4330 673 374 4602 PMC12238593__F5 Deregulated molecular signaling pathways and crosstalk in glioblastoma 4851 1950 1956 3082 7124 3553 3716 3717 4763 4041 4040 2932 324 5163 5728 1499 64798 2475 3550 7248 7249 6009 51176 PMC12238593__F6 Key immune signaling pathways regulating tumor-associated immunosuppression 6714 4087 4088 2475 4089 7535 3620 367 PMC12238593__F9 Transcriptional and epigenetic regulation and functional dynamics in CD8+ T cell exhaustion 2308 2309 2152 3399 9760 8320 3398 864 2833 PMC12239316__F6 Genetic model for evolution from all-black to all-white yak 3815 3845 5604 5605 4286 7306 1638 PMC12239985__F3 Hypoxia-inducible factor 1-alpha (HIF-1A) signaling pathway 3939 226 5211 2023 5163 1950 7018 2056 7012 1906 3162 PMC12240100__F2 Canonical Wnt/Beta-catenin signaling pathwayCanonical Wnt/Beta-catenin signaling pathway: the Wnt/Beta-catenin pathway regulates cell proliferation, differentiation, and survival 4041 4040 1499 324 6929 595 1950 960 PMC12240100__F3 Hedgehog (Hh) signaling pathwayThe Hedgehog (Hh) signaling pathway regulates embryogenesis, cell proliferation, and tissue repair 6608 2737 2736 2932 374654 51684 6469 9149 25989 PMC12240100__F5 PI3K/Akt signaling pathwayThe PI3K/Akt signaling pathway regulates cell growth, survival, metabolism, and angiogenesis 1956 5163 4193 7248 7249 6009 PMC12240100__F6 Hippo-YAP signaling pathwayOverview of the Hippo-YAP signaling pathway, including the interactions between MST1/2, LATS1/2, YAP/TAZ, and TEAD 55233 92597 60485 4485 26524 9113 PMC12240182__F1 Novel AR axis-directed therapy for the treatment of metastatic prostate cancer 1586 1583 367 PMC12240186__F1 Mechanistic basis of XPO1 dependency 7514 51564 1499 5925 7157 4609 6657 PMC12240642__F1 Ubiquitination‐mediated degradation of EGFR‐EGF complex and inhibition of downstream signalling in EGFR‐mutated cancer 1950 1956 6774 PMC12240740__F3 Network pharmacology results 5465 1401 6401 5925 598 4313 1950 11200 3565 4846 3156 5743 1509 338 5578 9536 7153 6531 3383 4314 7056 154 2064 4312 6347 2152 6373 3297 1870 596 2936 31 3551 1576 847 960 4170 5970 2353 6696 5241 6256 4318 4353 367 2920 207 3558 196 6720 3643 2099 1543 5894 1026 836 3725 4193 2194 653361 1956 581 6774 5111 3481 6257 7422 1147 2100 8626 4792 4609 5327 5328 1544 1869 959 4843 3627 5468 9429 3659 3553 3569 3552 3091 6772 3458 2908 PMC12240780__F3 LLPS regulates cellular phenotypes 3983 9776 60673 8408 PMC12240780__F4 LLPS in tumorigenesis due to FOs 1283 2885 6654 6760 3066 3065 PMC12240780__F5 LLPS in mutant tumor suppressor genes driving carcinogenesis 4771 324 1499 8405 1616 PMC12240974__F1 BAF60c in skeletal muscle glucose metabolism and regeneration 51804 64798 27122 PMC12241104__F1 Biosynthesis of shikimate 5805 50829 7086 PMC12241195__F5 Tackling Wnt signaling by the Wnt inhibitor SM04690 1196 1859 324 2932 2308 23411 387 10216 PMC12241215__F3 Diagram represents various therapeutic strategies targeting AML through different molecular mechanisms 945 355 6608 7157 4193 4149 581 PMC12242330__F1 Phenylpropanoids metabolism: recent insight into stress tolerance and plant development cues 1312 790 57716 PMC12243265__F9 RGCs damage in glaucoma were ameliorated via Gut microbiota-IAA-eye signaling pathway 4151 196 3553 3569 PMC12243992__F2 Palmitoylation of EGFR, VEGFR, ER and GP130 2885 1956 5873 54503 3589 51304 PMC12244502__F7 Mechanism by which NEDD4L prevents colorectal cancer liver metastasis 23327 207 10419 2475 PMC12245507__F4 Ferroptosis signaling pathway 7018 55240 2744 2937 2879 PMC12245687__F3 Signaling pathway mechanism of TLRs 7097 7099 54106 4615 7189 108348016 PMC12245687__F4 Mechanism of Rho/Rock signaling pathway 6093 387 6010 108348016 PMC12245687__F7 Mechanism of the Nrf2 signaling pathway 7421 9817 3146 PMC12245687__F8 Schematic diagram summarizing the mechanisms of intestinal signaling pathways 4615 6093 9475 387 7097 7099 54106 6010 7189 140609 79792 2475 114548 PMC12245688__F2 Action of HDACi on immune cells 7422 383 1277 6925 51176 11065 604 27250 PMC12245688__F3 Antitumor effects of HDACi 5696 4780 5693 4282 3976 59 1277 1869 65018 PMC12245885__F2 Major mechanisms of platelet aggregation 4512 7450 140805 PMC12245910__F2 The TSCC in the mTORC1 signaling pathway 983 51256 7249 6009 7248 64798 2475 64223 PMC12245916__F2 Signaling pathways for intestinal microbiota regulating the polarization and activation of intestinal macrophages 4615 3661 3569 6778 PMC12245917__F1 Molecular signal pathways related to H 4041 4040 92610 7189 7186 23118 257397 983 324 1499 5971 9462 115004 3661 1045 79923 4485 60485 9113 5163 4312 4314 4319 4318 PMC12245917__F2 Crosstalk among H 5163 10413 9462 1499 PMC12245983__F4 Notch signalling pathway upon activation, Notch receptors release signal-transducing Notch intracellular domain (NICD), which moves into the nucleus where it interacts with CSL nuclear proteins, forming CSL-NICD transcriptional complex 4851 23462 3280 PMC12245983__F5 PI3K/Akt/mTOR signalling pathway is activated upon binding of growth factor to receptor tyrosine kinase (RTK), which results in autophosphorylation of tyrosine residues and recruits phosphatidyl-inositol-3-kinase (PI3K) to cell membrane 5728 2475 4193 PMC12245983__F6 Hedgehog pathway is mediated by ligand HH, upon binding to PTCH the SMO inhibition is weakened, allowing its translocation to plasma membrane leading to HH pathway activation 6608 2735 51684 2736 2737 PMC12245983__F7 Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models 2475 2735 7054 1499 3280 PMC12245985__F7 Late‐stage DMD skeletal muscle transcriptomic changes in TGFB signalling pathway 7040 1756 652 710 6424 338442 4086 4090 440279 7157 4089 8038 PMC12246121__F11 Translation regulations in PRRs 148022 2475 1998 1999 7124 7072 1977 1938 26253 1326 1984 PMC12246121__F14 PRR in ageing 3146 7100 3394 7097 7099 54106 115004 PMC12246121__F1 Key discoveries in PRRs 7099 3630 22861 115004 325 PMC12246121__F2 Structure of different PRRS in the cell membrane and the extracellular 1283 114609 4615 26253 4153 3663 3665 283420 160364 1378 7054 325 1401 5806 PMC12246121__F3 Structure of different PRRS in the cytoplasm and nucleus 3663 3665 115004 29110 3181 114548 4261 4671 79671 3661 6240 6241 9447 140609 79792 PMC12246121__F4 Signaling pathways mediated by iPRRs and their regulation 11314 634 201633 5817 1445 PMC12246121__F8 Distinct signaling pathways in the recognition of PAMPs and DAMPs by PRRs 4615 7096 7097 10333 7099 7100 51284 54106 148022 7098 79792 51311 9447 2002 1386 115004 3661 3665 6262 PMC12246121__F9 Transcriptional regulation in PRRs-mediated inflammatory response 5595 5597 4200 4199 7099 PMC12246546__F5 Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors 387 1894 595 472 388 PMC12246546__F8 Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors 59341 3717 387 10331 PMC12246557__F5 Type I, type II, and type III interferon signaling and IFN‐I pathway‐related inhibitors 3716 7297 6772 10379 6773 3717 PMC12246557__F3 Nucleic acid sensors and downstream signaling pathways induce type I IFN production 51284 51311 4615 3663 51135 3654 3665 7189 7187 5132 7297 6773 6772 10379 PMC12246835__F2 Underlying renoprotective mechanisms of anthraquinones by inhibiting TGFB1/Smad and Wnt1/Beta-catenin signaling pathways 7046 4087 4088 4041 4040 4092 324 4089 1499 PMC12246835__F3 Underlying renoprotective mechanisms of anthraquinones by regulating IƙB/NF-ƙB, Keap1/Nrf2 and PI3K/Akt/mTOR signaling pathways 9978 8452 9817 4015 2729 2730 1728 5163 7248 7249 8473 6009 2475 1977 5728 PMC12247361__F2 miR-1303 regulates cancer progression through targeting multiple genes across distinct cancer types 27122 100302284 7094 6422 9073 PMC12248293__F9 BRD4770 attenuating DOX-induced cardiac injury through the Nrf2/ATF4/SLC7A11 pathway 23657 2879 468 PMC12248764__F5 Fatty acid synthesis pathway in L 52 54626 95 PMC12248877__F1 PI3K/Akt/mTOR signaling pathway and the respective inhibitors used in TNBC 2475 5163 5728 PMC12249078__F3 Molecular mechanisms lead to uterine fibrosis 4087 4088 4089 1499 2475 7018 PMC12249179__F8 Correction: Ye et al. The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer. Cancers 2022, 14, 2101 652995 60674 693198 PMC12249569__F1 Mechanistic model linking gut dysbiosis, insulin resistance, and autism spectrum disorder 7097 7096 4615 3667 7189 7124 PMC12249733__F5 Involvement of the DEGs of NC and IC associated with effects of ACTH(6-9)PGP peptide a day after IR conditions in striatum 57180 8792 11006 3726 5600 834 7060 4773 653361 925 3665 1536 8935 4314 6403 5293 4973 10451 6401 9641 2353 19 150 2900 7068 130576 5179 885 6863 4922 90226 5028 551 719 8622 3763 9001 2897 10874 2668 817 2558 2556 2572 493 140679 773 799 1395 27006 2906 6752 9568 10846 7852 5020 90550 5582 PMC12249743__F5 Representation of epidermal human cell infection by SARS-CoV-2 and antiviral mechanisms 6773 29110 1636 115004 PMC12249962__F2 Key metabolic pathways, transcriptomic modulation, and chemotherapeutic and metabolic compounds for prostate cancer treatment 7018 367 3091 PMC12249962__F3 Multi-target promising compounds for prostate cancer (PCa) treatment 2180 3098 3099 3939 2194 47 PMC12249970__F4 The AhR in modulating adaptive immune responses 196 9049 6774 50943 920 PMC12249970__F5 Activation of AhR by kynurenine, leading to the differential modulation of T cell subsets 196 3458 1543 339855 405 PMC12249970__F7 AhR and JAK/STAT pathway crosstalk in immune regulation 3565 3458 7297 3717 3716 6774 11213 1235 196 405 9021 23118 10454 4513 PMC12250001__F2 Principal molecular mechanisms involved in the MAPK, NFKB, and PI3K/Akt signaling pathways activated by oxidative stress in OA 5728 4322 11096 7071 PMC12250001__F3 Principal microRNAs and targets involved in inflammation and cartilage destruction in OA 7412 83596 4322 4314 11096 1839 6667 23411 PMC12250041__F1 Experimental Models and Their Applicability in Inflammation Studies: Rodents, Fish, and Nematodes 7097 7098 7099 4615 6772 PMC12250049__F1 Hippo signaling pathway 4485 60485 55233 92597 26524 9113 7004 8463 7005 7003 PMC12250376__F9 Overexpression of (P)RR in SHR and Renin-Induced HepG2 Cells Leads to Spontaneous Hypertension Combined with Metabolic Dysfunction-Associated Fatty Liver Disease 948 2194 7038 PMC12250417__F4 Signal transduction mediated by BCR, FcRL1, CD19, and BCMA receptors on B-cells 613 930 115350 4067 2885 6654 6850 695 5336 998 387 5111 PMC12250459__F4 Neuroprotective mechanisms of AOF 54209 7099 4615 51135 7189 3479 627 6714 2885 10454 23118 572 581 7249 2475 5966 PMC12250560__F4 Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bowel Disease and Monogenic Intestinal Disorder Pathogenesis 64127 55054 8767 331 83737 PMC12250682__F7 Multifaceted antitumour mechanisms of Astragalus polysaccharides (APS) in liver cancer 595 581 999 1000 PMC12251195__F2 Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1)-mediated immune evasion in the tumor microenvironment 3902 3845 8205 100187761 PMC12251215__F2 Wnt Signaling Pathways: canonical (Wnt/Beta-catenin) and non-canonical (Wnt/planar cell polarity, PCP and Wnt/Ca2+) pathways 324 4041 4040 4920 4919 5879 23002 1499 387 PMC12251215__F3 In esophageal and gastric cancers (EC and GC, respectively), circRNAs modulate Wnt/Beta-catenin signaling through various mechanisms 7976 100302155 2638 140809 6659 83737 1499 PMC12252150__F2 Molecular mechanism of ERF3, SR4, DRM6-1, CHL1, NRL1, PM1, DMP2 and their role in resistance to P 4901 23075 4881 PMC12254190__F5 MiR-152 in hematologic malignancies, including multiple myeloma (A), AML-NPM1 (B), diffuse large B-cell lymphoma (C), non-Hodgkin lymphoma (D), chronic myeloid leukemia (E), and acute lymphoblastic leukemia (F) 1786 100506311 104472715 283120 22943 25989 23476 338005 488 PMC12254754__F2 Schematic illustrates that inhibition of GLUT1 results in an increase in the tumor OXPHOS pathway, leading to excessive production of ROS, which subsequently promotes TNFAlpha-mediated cell death 2833 4283 3627 PMC12255092__F1 Cholesterol structure and synthesis 3156 1717 1718 PMC12255092__F6 Therapies that target lipid metabolism 348 19 9619 54209 PMC12255454__F6 The sphingolipid metabolic pathway and biochemical tools for its investigation 10558 9517 29095 94103 94101 2531 204219 91012 29956 79603 10715 3995 340485 55331 125981 8694 84649 PMC12255454__F7 Metabolic building blocks within the sphingolipid pathway and their subcellular localization 80772 64781 10087 340485 125981 204219 91012 29956 79603 10715 55331 PMC12255454__F8 Pathway map for individual molecular subspecies of sphingolipids beginning from production of the sphingoid base backbone through subsequent metabolic steps, emphasizing key branchpoints (nodes) 4838 9896 204219 29956 9350 95 PMC12256062__F8 Antagonists of cGAS-STING pathway for liver diseases therapy 114548 29110 7494 115004 3661 PMC7617722__F3 Fatty acid metabolism and its regulation by E5, E6 and E7 encoded by HPV oncoproteins 1956 2194 47 355 95 PMC11932283__F6 Cerebral CYP enzymes in major exogenous substance metabolism—opioid biotransformation 1576 1565 1558 PMC12018393__F4 Tamoxifen metabolic pathway 1576 1565 1559 PMC12018393__F6 Toremifene metabolic pathway 1576 1577 1565 1559 PMC11529284__F3 Sodium taurocholate co-transporting polypeptide expression 23411 999 9965 2264 3172 PMC11641621__F3 Schematics describing the role of particular small-molecule protein kinases and their inhibitors in PAH microenvironment, including such molecular hallmarks as inflammation, apoptosis, proliferation, or mitochondrial function 1956 4921 2322 238 2475 PMC11670821__F3 Immune responses mediated by (H) pylori OMVs and infected cell exosomes 7099 958 975 967 4615 PMC11726960__F2 Key characteristics of models used to recreate cardiac systems in vitro and relevant signaling pathways 90525 4041 4040 324 1499 652 3479 100653366 PMC11734361__F3 Tumor-associated-mycobiome mechanisms involved in triggering oncogenesis and cancer development 90865 8205 6774 64170 114548 PMC11753526__F2 Comprehensive examination of the Toll-like receptor 9 (TLR9)-mediated signaling pathway 4615 114609 7097 23118 257397 3654 51135 7189 3569 7124 6364 6347 PMC11769975__F3 Possible molecular mechanisms of Fusobacterium nucleatum in tumor progression [This figure was created using MedPeer (www 8767 114548 1499 330 7099 PMC11809324__F7 Treg cell aging and regulatory role of PD‐1 in advanced‐age pregnancies 4280 1846 940 PMC11836306__F1 TORC1 pathway in humans and yeast, derived from Refs3,19 201163 96459 54468 6396 79726 84219 9681 4883 4882 7248 6009 7249 64223 64798 652968 729438 144577 11133 55846 23334 PMC11880140__F2 Roles of five types of decidual innate immune cells in the regulation of labor initiation and PTB 7097 4280 5896 PMC11394960__F7 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the liver in Lagovirus europaeus infection 114548 4615 7099 3654 7189 23118 PMC11394960__F8 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the lungs in Lagovirus europaeus infection 7099 4615 3654 7189 114548 23118 PMC11394960__F9 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the kidney in Lagovirus europaeus infection 7099 4615 3654 7189 114548 23118 PMC11394960__F10 Contribution of miRs/target genes involved in the innate immune and inflammatory response pathway in the spleen in Lagovirus europaeus infection 4615 114548 7099 3654 7189 23118 PMC11395697__F4 The colitis-associated cancer pathway in inflammatory bowel disease 6774 324 7157 PMC11397714__F1 Canonical TNFA signaling pathway activates NFKB through TNF receptor binding, involving TRADD, RIP-1, and the IKK complex, leading to the transcription of various genes that are involved in the immune response (Created with https://www 23118 257397 5970 PMC11414398__F7 Alternative Src regulatory pathway mediated by the METTL18-RPL3-HSP90-actin axis in HER2-negative breast cancers 92342 6122 6714 PMC11435552__F1 Suppression of Interferon Response and Antiviral Strategies of Bunyaviruses 7098 57506 3240 7187 7189 29110 8780 3665 3661 2638 3654 51135 100188864 4615 3669 9636 PMC11456611__F7 Colorectal cancer: therapeutic targeting of oncogenic signaling cascades 7248 7249 5728 595 5163 PMC11464740__F3 JAK/STAT signaling pathway can be activated or inhibited by inflammatory cytokines to regulate the inflammation of UC 3717 7297 3458 PMC11467144__F2 WNT signalling pathways in the intestinal crypt and potential therapeutic targets 4041 4040 54894 84133 1499 324 3981 PMC11477111__F6 Regulatory role of FMR1/FMRP on BMPR2 in granulosa cells 9210 2661 659 238 2332 PMC11489006__F3 Hippo pathway and crosstalk with other signaling pathways in CRC 1499 2695 6925 PMC11493653__F2 MiRNAs in key phases of diabetic wound healing 6774 4312 80310 442904 PMC11499591__F3 ApoM/S1P, Wnt/beta-catenin, and PI3K/AKT/mTOR signaling pathways involved in intestinal barrier damage 8877 55937 1499 23410 2475 PMC11506032__F5 Pathophysiology, Treatment, and Prognosis of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome: A Review 10563 7422 6772 6773 6774 2475 PMC11506742__F1 TLR/IL-1R signaling pathway 4615 51135 3654 3656 6774 7189 PMC11518755__F1 Molecular alterations of RAI-RTCs 5979 238 5728 2475 673 7849 7157 196528 PMC11520086__F3 Metabolic pathway and enzyme gene expression difference of C1 compounds in the transcriptome group, Formaldehyde vs 54433 81888 2645 11113 PMC11520424__F3 STAT3 in HER2-positive breast cancer 1950 6774 6714 3717 PMC11520425__F1 Classic Wnt/Beta-catenin signaling pathway: mechanisms in closed and open states 4041 4040 324 1499 PMC11530992__F1 Canonical pathway and non-canonical pathway of NFKB signaling pathway 613 8915 10892 5966 PMC11539471__F2 Mechanisms of action of clinically studied CAR-T targets in gliomas 3596 1969 3598 7422 6778 6774 2475 PMC11542157__F2 Signaling pathways regulating CMA activity 2670 2475 7942 PMC11542157__F5 CMA and neurodegenerative diseases 114548 4209 7942 PMC11546859__F12 Analysis of the pentose phosphate metabolic pathway 2539 25796 9104 PMC11547603__F3 Activation and interaction of both canonical Wnt signaling and non-canonical Wnt/TGFB 324 847 4087 PMC11551531__F3 NFKB signaling pathway in macrophage polarization 3661 4615 7124 PMC11551676__F1 Wnt signaling pathway 3458 7939 1499 324 PMC11567945__F1 Alterations of paracellular permeability in Alzheimer's disease (AD) patients and numerous AD models 361 1003 4318 387 PMC11590683__F1 Catabolic pathways of glucose metabolism in KT2440 6120 22934 1896 PMC11591800__F2 MTOR signal pathway 5163 3667 51256 664 6009 64798 375 PMC11594236__F2 Cells of innate immunity and network of mediators in OA synovitis 929 30835 6778 6772 10578 PMC11595780__F4 Intratumoral microbiota promotes tumorigenesis and tumor progression through several mechanisms 999 6774 1499 PMC11598946__F3 Cytosolic sensing of BRSV by RIG-I, MDA-5, and NOD2 57506 7189 3661 64127 PMC11599795__F2 In bladder cancer, YAP1 activity is regulated by YAP1 gene expression, post-transcriptional mRNA modifications, and the activity of the Hippo signaling pathway 26524 9113 10413 PMC11602477__F1 Wnt/Beta-catenin pathway in CSCs 1499 6010 324 51199 PMC11603874__F11 Anti-TNFR2 bs-Ab mechanism of action 9242 383 1956 PMC11606877__F3 Anticancer role of RES against NMSC: Focusing on oxidative stress, cellular, and molecular mechanisms 847 7124 1499 PMC11610372__F7 Mechanism diagram of berberine acting on tuft cells to relieve colitis 64806 847 29850 PMC11617312__F3 Canonical Wnt/Beta-catenin signalling in epithelial homeostasis and HPV-modulated homeostasis 1499 324 9368 6477 PMC11621776__F6 Five signaling pathways associated with macrophage polarization which are highlighted by pink color 2998 90865 3458 PMC11635105__F4 STRING protein-protein interaction networks for the differentially methylated circadian pathways-related genes in HS 53918 175 1479 PMC11641450__F2 Modulation of WNT/Beta-catenin signaling pathway by natural compounds in cancers 22943 4041 4040 2932 324 1499 607 PMC11652361__F1 Siglec-15 affects four key areas: bone metabolism, modulates infections caused by pathogenic microorganisms, immune regulation, and the pathogenesis of hematologic diseases 7189 960 8161 3553 PMC11656820__F3 Function of dysregulated Tim-3 pathway in sepsis-induced immunosuppression 3600 3565 3586 50943 7054 PMC11657697__F3 Correlation between inflammasomes and HSCT 325 355 7054 920 PMC11667780__F3 Mechanisms underlying mTOR regulation in macrophage differentiation 7248 7249 64798 PMC11667996__F1 Activation and signaling pathways of the MAPK Cascade: an overview of stimuli, cascades, and downstream targets: this detailed illustration outlines the four central signaling pathways within the MAPK framework: ERK5, ERK, JNK, and p38/MAPK 2885 7248 7249 51135 3654 6667 7189 PMC11668132__F1 Quercetin on cancer cell growth and proliferation 324 1956 472 PMC11670207__F7 DEGs in growth-related pathways 3716 6774 2475 8569 5105 5106 6655 22800 2885 5295 5293 3551 2310 PMC11671274__F1 Intestinal changes in T2DM 4615 5697 3553 3458 PMC11674327__F1 Extra-ribosomal functions of two RPs activating the NF-kB pathway during viral infection 6137 8467 3921 PMC11678759__F3 Signaling pathways of melatonin 4199 23066 5597 PMC11682976__F1 Angiogenesis and EMT regulators in the tumor microenvironment in lung cancer and immunotherapy 7428 2056 7424 5156 PMC11685696__F3 Mechanism by which intestinal microbiota regulates intestinal mucosal injury through STING pathways 115004 3661 29110 PMC11688492__F2 The molecular mechanisms related to SARS-CoV-2 and S protein effect on vascular dysfunction and BBB disruption 3553 59272 6868 PMC11689543__F3 Enhanced thrombopoiesis in sepsis 7173 7097 6774 51129 PMC11699442__F4 Dietary acrylamide on kidney and liver health: Molecular mechanisms and pharmacological implications 2475 581 3569 PMC11705637__F4 Main pathways involved in INPP5E activation 51684 56623 6790 PMC11724515__F4 Vitamin D on obesity and bone 23411 7038 114548 PMC11724515__F8 Sirtuins 1/3/4/6 exert disparate influences on stem cell differentiation and insulin secretion 23409 51548 3651 23410 PMC11727624__F1 Biological processes of the canonical Hedgehog (Hh) signaling pathway 51684 55733 57758 6608 156 64399 3240 22944 PMC11734547__F6 Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) 2798 847 1956 3709 998 2885 PMC11735109__F11 Schematic representation showing a possible mechanism of YAP1-driven induction of immunosuppression in UCB mediated by the IL-6/STAT3 pathway 3579 10413 6774 PMC11743330__F2 MiR‐30a‐5p inhibiting the Wnt/B‐catenin signaling pathway 4041 4040 324 PMC11747879__F2 Activin signalling pathway 10272 4087 4088 4089 PMC11755087__F2 Schematic diagram showing insulin pathway in C 5163 6446 207 PMC11757730__F7 Anti-inflammatory effects of chamuangone in lipopolysaccharide-induced murine (Mus musculus) RAW264 1121 4615 7099 PMC11762942__F4 Relationship between lipid metabolism and OA pathogenesis 9023 3091 50507 9420 PMC11763651__F1 Biosynthesis of BH4 and genetic diseases due to BH4 deficiency 367 1719 7054 PMC11764157__F6 CBG on AD models 3553 85480 90865 3717 3716 7297 PMC11781165__F1 Intestinal bacteria and their metabolites on physical barriers 7099 4615 324 1026 1499 4827 PMC11782603__F8 Using SEC-MX to provide molecular insights 1025 983 2799 5163 207 84335 7249 7248 545 7157 11200 6195 83667 6009 10670 64121 9681 10641 8131 64223 64798 6198 1978 6416 399972 PMC11788444__F5 Crosstalk between dysregulation of metal ions and pathological proteins in neurodegenerative diseases 5072 351 1020 3064 6667 PMC11794105__F1 Signaling pathway regulating EMT in epithelial cells 4087 324 1499 3725 PMC11808223__F1 Intestinal changes in T2DM 4615 5697 3553 3458 PMC11809362__F2 RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis 6667 1786 8434 PMC11810091__F7 Changes in mucosa branched N-glycosylation impacts gut microbial balance, leading to an intestinal inflammatory response 4249 2524 64127 PMC11810460__F3 Schematic representation of cellular targets of HDACi and targeted BRAF mutant therapy concepts of relevance for cell death mechanisms 673 2885 2475 23657 55364 PMC11814453__F4 The mechanism by which sodium channel inhibition exerts anti-tumor effects 2475 3661 6714 PMC11821285__F3 Proposed pathways and molecular interactions for ARI's anticancer effects 3717 1355 3357 6774 2475 1857 6714 PMC11823264__F4 JNK signaling pathway 8717 1616 998 4318 PMC11830176__F1 HBME inhibit LPS activated canonical NF-kB pathway in microglia and its effectors 7099 4615 3654 51135 7189 114548 PMC11830738__F7 Interaction between malignant T cell and CAFs with SOX4-related mechanisms in the process 6774 6659 7291 2146 1499 PMC11837354__F1 Main metabolic pathway of catecholamine biosynthesis 7054 1644 1621 PMC11839412__F3 Crucial miRNAs impacting CD133 and cell cycle regulation (By Figdraw 1019 595 1847 5873 PMC11849352__F1 TLR3 signaling pathway 7098 7189 7187 3661 PMC11850097__F11 Action of ZIP8 in macrophage polarisation and IDD 7039 11096 4322 PMC11853349__F7 Protective mechanism of dapagliflozin in sepsis-induced cardiomyopathy: The SIC model was established by animal experiments 6774 5880 56980 PMC11853781__F3 Luteolin multi-pathway treatment of IBD 6774 3586 9817 847 PMC11853993__F7 CD73 downregulated expression induced by TgROP18 and its consequences on dMφ dysfunction 84890 10682 383 PMC11854313__F2 Biosynthetic pathway of terpenoids 4598 3652 727 412 PMC11858545__F8 Danggui Beimu Kushen Pill Alleviates Colitis-Induced Inflammation in Mice by Regulating the IL-6/IL-6R and IL-17A/IL-17RA Signaling Pathways 3716 3717 7189 6774 PMC11859690__F2 Action of anti-HER2 drugs 324 5728 2475 PMC11863469__F11 TGFB signaling in GBM progression 7045 4087 3558 PMC11878485__F4 The Wnt/Beta-catenin signaling pathway 1499 4041 4040 324 595 PMC11881714__F2 Normal copper metabolism 1356 540 538 475 10063 1353 9973 6647 PMC11897526__F2 Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway 3717 7297 6774 6775 PMC11900433__F8 MAPK/AP-1 signaling pathway 5879 9261 8550 7867 PMC11903573__F2 HDACs and KATs that are involved in adipose tissue regulation 3065 7391 63924 7350 9370 2308 63976 PMC11906485__F1 Biosynthetic pathway of plasmalogens and RCDP types based on gene mutation 5191 5830 8540 84188 PMC11906670__F2 Biosynthesis pathways and receptors of AA-derived eicosanoids and their influence on cDC migration 4015 1236 10800 57105 4512 4049 PMC11915259__F3 Microbiota disruption leading to an inflammatory environment 3569 7099 7249 2475 PMC11920859__F1 Gli pathway-targeted Co(iii) Schiff base complexes inhibit migration of basal cell carcinoma cells† 5727 6608 51684 PMC11931723__F7 Genomic potential for tryptophan and indole-3-acetic acid (IAA) synthesis in Anza-Borrego isolates of Bradyrhizobium and Methylocaldum 1644 9191 5481 PMC11934714__F5 HERV in the pathogenesis of ALS 80150 115004 29110 3661 3665 PMC11941770__F1 Differentiation of T helper (Th17) Cells and Interleukin-17A (IL-17A) signaling pathway 324 920 6774 4087 7186 7188 7189 PMC11942346__F1 Mechanisms of adhesion formation: (1) Inhibition of fibrinolysis and ECM deposition 5340 4092 4088 PMC11951496__F1 Double role of IL-6 in the pathogenesis of atherosclerosis 114548 4615 7097 7099 PMC11952772__F1 Possible mechanism of Lactobacillus alleviating sarcopenia 7097 7099 847 55364 PMC11955304__F5 STAT3 signaling pathway can be targeted using various therapeutic agents 6714 6774 1357 PMC11955613__F2 Apoptotic and necrotic osteocytes promote osteoclastogenesis 581 3383 7422 836 PMC11961428__F4 Proposed inflammatory mechanisms hypothesized to underlie HACE 361 114548 2668 PMC11965140__F7 Immune regulation of CORT depends on GR signaling and 11Beta-HSD 1325 2908 2308 2475 627 383 2309 PMC11965601__F3 Flavonoids in inhibiting retinal cell apoptosis 3383 627 4803 PMC11967956__F7 Summary scheme of the obtained data 7422 4397 2475 PMC11968978__F9 Small molecule therapeutic drug map targeting all parts of the Wnt pathway 7551 54894 22943 4041 4040 6259 2932 324 64840 1499 4512 4513 717 PMC11969448__F1 miRNA-dependent resistance mechanisms to anti-hormonal therapies in estrogen receptor-positive breast cancer patients 1956 5728 2932 324 1499 2475 442909 1019 1021 1017 693160 983 596 7018 406925 PMC11975009__F2 VPS35 in Neurodegenerative Diseases 1509 55737 4040 23621 83959 1020 1499 54209 2521 PMC11975862__F7 Active ingredient–shared target–pathway network analysis 4193 5972 6462 PMC11978336__F2 Interaction between lipid metabolism and macrophage polarization in atherosclerosis 1401 64241 1581 64240 PMC11978694__F2 Molecular pathways involved in gouty arthritis and potential miRNA regulators 79792 7099 5728 4615 23411 387 2475 114548 PMC11979251__F3 Molecular mechanisms of immunogenic cell death (ICD) related to reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress 22926 6667 468 PMC11979484__F9 Hi-Exos in relieving the senescence of NPCs and IDD 27161 3569 54541 PMC11979968__F4 Distribution of the seven core targets in the serotonergic synapse signaling pathway and the drug‐pathway‐target‐disease network 1644 126669 1956 1268 4318 2099 3360 PMC11980037__F5 Downregulation of Tnf, Il1a, and Il1b in M2c macrophages exhibited immune tolerance in autoimmune diseases 7097 7099 50615 50943 324 8231 PMC11987923__F3 Tumor immune microenvironment in cholangiocarcinoma 3845 7157 324 2263 PMC11994599__F9 Salvia miltiorrhiza Bunge root in the treatment of myocardial fibrosis: research progress and challenges 7099 4615 581 50507 PMC12009910__F3 Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway 10454 23118 257397 PMC12016237__F2 Mechanisms proposed for the AS-IV action in animal models of cardiovascular disorders 114548 7124 355 79792 4087 PMC12022909__F2 Rewired Yonemitsu MCR: scope and mechanistic insights 367 472 847 PMC12025505__F2 Signaling Mechanism of Budding, Proliferation, and Tissue Regeneration in Cnidaria 26524 9113 1499 324 PMC12028493__F12 Proposed mechanism underlying the anti-PD effect of epicoccin A 2937 847 119391 65018 6647 6648 10533 9140 83667 5562 10891 7248 2475 10376 PMC12035766__F5 Molecular hydrogen inhibiting CRC growth 7248 7249 6009 PMC12043837__F4 Regulatory role of lactylation in glioma pathology 220 28999 3939 PMC12049823__F1 Genetic regulation of SPP1 regulated by TFs and the signaling pathway in disease 860 3219 2735 4282 960 1499 6774 PMC12052750__F4 Gut microbiome imbalance disrupts the gut-lung axis 114548 3553 3458 PMC12055712__F8 Model illustrating the regulatory role of Roraa in circadian rhythms and metabolism 7008 4783 9575 56938 8864 8863 6096 6097 PMC12062509__F7 Cancer-related pathways in cuproptosis 1317 4891 23657 2597 9833 2230 11019 5163 16 57505 79066 538 540 1499 6925 PMC12064795__F7 Schematic diagram for the mechanism of SYT7-ALDH1A3 axis mediated carcinogenesis in NPC 9066 220 6774 PMC12065456__F3 Communication between cancer-associated fibroblasts and specific tumor cells via integrins 2638 4087 387 7058 948 7852 1000 PMC12065540__F1 Pathogenesis of Diabetic Ulcers 7124 5163 2475 PMC12068294__F2 Bioactivities of stem cells cultured on fish-derived biomaterials 7099 2841 2854 PMC12070581__F9 Map of specific pathways under imazapyr acid stress 10993 6396 258010 100187907 22926 5111 2237 3978 PMC12071115__F5 TFPI2 in pregnancy-induced hypertension, diabetes, and atherosclerosis 7124 2145 1786 PMC12078210__F4 IL-21 promotes the formation and maintenance of germinal centers and plays a decisive role in the differentiation of GC-derived B cells into plasma cells 613 2638 5079 PMC12095162__F3 NOD2 receptor signaling pathway 10454 257397 23118 8767 64127 PMC12097394__F2 TLR/NFKB mediated inflammatory signaling and involvement of E3 and DUBs 54726 114609 7375 9100 4615 8405 114803 7189 3553 3569 PMC12100877__F2 Emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome 3553 114548 2625 9589 79068 367 2638 PMC12110172__F1 Hippo-YAP pathway 4485 60485 26524 9113 PMC12111248__F9 Cdh23 regulating rod cell calcium ion transport (image created by Figdraw) 64072 2779 6010 2979 2638 PMC12115913__F2 The molecular mechanisms triggered by the interplay between SARS-CoV-2 S protein, ACE2, and integrin B1 receptors 3553 6868 7018 59272 PMC12116884__F9 PF ameliorates neuroinflammation induced by ABO 383 968 627 6855 PMC12133868__F2 MAPK signaling pathway 5979 673 7249 2475 572 PMC12141845__F1 Canonical Wnt signalling pathway with osteokine and pro-inflammatory marker inhibitors 50964 4041 4040 PMC12143691__F1 Gut microbiota interacts with the mammalian epigenome by generating epigenetic substrates or acting as regulators for chromatin-modifying enzymes 2648 56339 54890 9589 57721 79068 PMC12146343__F2 Signals from the gut microbiota lead to the differentiation of T cells into various subtypes 2475 7099 4615 50943 2625 7039 PMC12148668__S1 Schematic diagram illustrates the preparation of IFNG treated RAW 264 4810 3553 2638 PMC12154509__F4 SIRS signaling: inflammatory pathways during shock and cytokine storm and the production of soluble cytokine receptor antagonists 51135 4615 7189 PMC12163381__F4 ILs with dual functions 90865 3718 3716 6778 6761 6774 6772 PMC12183514__F1 Mechanism of estrogen improving brain function, regulating lipid metabolism and alleviating osteoporosis 627 3479 7038 PMC12191313__F3 Molecular Mechanisms of Epithelial–Mesenchymal Transition in Retinal Pigment Epithelial Cells: Implications for Age-Related Macular Degeneration (AMD) Progression 324 1499 4092 5228 7124 6935 999 23462 PMC12193433__F4 IL-6/JAK/STAT3 signaling pathway and oleocanthal-mediated inhibition 3716 6774 595 4313 PMC12197721__F3 Proteins encoded by multigene family genes (MGFs) involved in the NFKB signaling pathway 114548 3838 3840 3839 PMC12203119__F2 Intestinal immunity and microbiota in gut health 7099 51284 7098 54106 PMC12203532__F5 A) GNN explainer outputs node and edge importance for each sample 1805 89910 131450 2628 PMC12203940__F1 Wnt signaling pathways 4041 4040 324 6259 387 6010 1499 PMC12204001__F3 Protumor role of cGAS-STING pathway 115004 29110 3661 PMC12205135__F3 Molecular mechanisms of peripheral sensitization in cancer pain 623 624 6347 7442 PMC12213698__F1 Basics of the canonical Wnt signaling pathway 3553 4041 4040 1499 324 3565 920 3458 PMC12230849__F5 Factors influencing VSMC apoptosis and their signal pathways 317 207 4170 3479 7189 2539 PMC12235269__F3 Fig. 3. JAK-STAT signalling pathway and JAK inhibitors in ulcerative colitis 2056 7173 29949 3976 5008 3718 3717 7297 PMC12237660__F1 MASH (Metabolism and immune response) 355 54209 729230 PMC12245687__F6 Mechanism of the Wnt signaling pathway 4041 4040 324 1499 PMC12245701__F2 TGFB inhibitors: the future for prevention and treatment of liver fibrosis? 6010 5163 2475 PMC12254798__F1 Obese adipose tissue (AT) microenvironment interacts with tumor cells during cancer progression 114548 6774 2167 3586 Statin pathway%WikiPathways_20260211%WP1%Mus musculus Statin pathway 16971 11814 11813 15450 11808 13350 16956 20778 18830 16835 11303 13122 15357 11806 20652 16816 17777 11812 11816 IL 9 signaling pathway%WikiPathways_20260211%WP10%Mus musculus IL 9 signaling pathway 20851 384783 12702 20848 26395 16451 16186 54721 26417 11651 20846 16367 18708 81601 16199 19247 16198 20850 14784 269523 26396 20416 16453 26413 Cholesterol biosynthesis%WikiPathways_20260211%WP103%Mus musculus Cholesterol biosynthesis 18194 110196 208715 66234 20775 319554 192156 13121 15357 13360 68603 235293 14137 16987 17855 Selenium metabolism selenoproteins%WikiPathways_20260211%WP108%Mus musculus Selenium metabolism selenoproteins 109815 107585 107869 223776 232223 214580 20342 80795 27361 13370 20687 19946 65967 14778 625249 50880 26462 69227 75420 71787 18986 20768 71984 75512 19697 14080 14281 28042 20363 13371 72657 20226 50493 20683 211006 109079 12916 14775 114679 20341 20364 280621 18024 14776 16476 18033 74777 TGF beta signaling pathway%WikiPathways_20260211%WP113%Mus musculus TGF beta signaling pathway 21814 24136 21803 55994 16451 26420 17125 12393 21815 20481 17128 12159 21926 14313 14225 20750 22408 21813 21825 16878 18121 16842 13805 17130 20482 94187 26417 12399 21812 18033 17127 68010 328572 18787 16323 268977 17126 20848 230597 15978 16476 17131 14106 15461 12387 14281 209446 13645 20846 12914 17129 16420 Hedgehog signaling pathway%WikiPathways_20260211%WP116%Mus musculus Hedgehog signaling pathway 14632 24069 13548 16147 14451 268697 19207 13363 12914 12534 14634 15245 19206 20423 16002 20481 19335 269209 319757 20220 14633 20466 Glucuronidation%WikiPathways_20260211%WP1241%Mus musculus Glucuronidation 216558 109785 226041 66681 15275 22235 72157 394433 613123 72094 71773 100727 394430 94215 394436 552899 22236 Non homologous end joining%WikiPathways_20260211%WP1242%Mus musculus Non homologous end joining 22596 14375 19090 17535 108138 75570 19360 75570 EBV LMP1 signaling%WikiPathways_20260211%WP1243%Mus musculus EBV LMP1 signaling 26406 18034 26419 21926 19697 67399 71609 15977 16150 22034 12675 26409 18033 16179 22029 20304 53859 12675 16151 20297 26413 15519 Estrogen signaling%WikiPathways_20260211%WP1244%Mus musculus Estrogen signaling 15182 26420 13871 24074 99730 20466 26413 17420 12443 229906 12043 69920 15183 13872 13982 12912 18706 328572 16150 20185 245841 231329 18747 20021 66464 12572 16476 14683 56233 12189 11651 74197 15185 102216272 108143 66420 14885 14884 14688 235459 68153 20779 15461 68705 16151 20022 20662 109880 26395 26416 18033 13712 216148 433759 21343 21374 17749 12914 76854 14281 69833 14784 16202 23894 226182 14699 67710 15184 70315 208727 209357 20020 66671 20683 12675 Transcriptional activation by Nfe2l2 in response to phytochemicals%WikiPathways_20260211%WP1245%Mus musculus Transcriptional activation by Nfe2l2 in response to phytochemicals 18750 26419 231872 12608 18024 50868 14629 15368 17132 13844 18706 14858 18104 14630 Methylation%WikiPathways_20260211%WP1247%Mus musculus Methylation 11720 232087 22017 18948 108645 140483 21743 18113 12846 Oxidative phosphorylation%WikiPathways_20260211%WP1248%Mus musculus Oxidative phosphorylation 75406 66043 228033 17992 595136 66218 227197 66091 11951 66916 68198 17705 407785 66377 78330 67264 68375 68202 230075 67273 66108 28080 66416 11950 68197 27425 17705 17706 17993 17720 407790 67942 68342 14939 71679 68349 72900 17721 17718 17991 226646 225887 54411 66046 67126 11958 11947 17716 68055 11957 70495 57423 67130 17722 69875 11946 17995 17719 17717 EPO receptor signaling%WikiPathways_20260211%WP1249%Mus musculus EPO receptor signaling 13857 16452 20779 30955 14784 13856 20416 228026 20846 26417 26395 26396 11651 26413 12703 20851 12700 20850 20848 19264 19273 110157 20662 384783 16367 218397 Arachidonate epoxygenase epoxide hydrolase%WikiPathways_20260211%WP1250%Mus musculus Arachidonate epoxygenase epoxide hydrolase 13850 12858 12868 13850 Metapathway biotransformation%WikiPathways_20260211%WP1251%Mus musculus Metapathway biotransformation 13120 64580 14860 110198 70646 69083 394433 17961 394433 56050 104086 17423 71519 14263 83398 50785 14872 72054 81906 15476 211666 15478 320997 14775 60322 22017 107146 140483 12012 14262 76969 14857 13081 53374 394430 56362 394434 13116 102294 56441 14865 14776 110115 394436 13077 11677 195646 269854 14778 13078 14873 77951 74134 20860 13075 13079 546726 20859 50786 13115 232174 14871 58810 14261 67877 552899 21743 18113 68312 545817 98956 58250 71367 330217 13122 14874 54371 13107 53897 319415 76263 545276 23908 13124 13076 14782 29859 50787 13072 14866 552899 15531 16497 67553 71797 13123 13070 72094 98388 69083 13849 66176 269642 20887 72117 628779 625249 244209 54710 54200 545963 14854 14780 13850 56773 14862 16499 55990 14859 16498 70999 226564 13082 13106 72136 73671 328779 13074 26887 56615 67861 68396 94284 14858 14870 12846 22236 66447 208665 68214 14866 381334 68947 13121 59031 Amino acid conjugation of benzoic acid%WikiPathways_20260211%WP1252%Mus musculus Amino acid conjugation of benzoic acid 107146 60525 Type II interferon signaling IFNG %WikiPathways_20260211%WP1253%Mus musculus Type II interferon signaling IFNG 20847 15978 20846 20375 16391 15900 16452 16451 17329 12703 13058 19247 15894 16363 15980 14468 21354 15979 97122 15977 16176 19106 100038882 18126 16362 15945 16912 12702 18753 16364 15958 12265 19692 Apoptosis%WikiPathways_20260211%WP1254%Mus musculus Apoptosis 58801 12371 17246 12018 22031 16362 18033 14102 11797 66593 11651 14940 94185 12015 18035 12362 19766 16363 18036 16992 12363 54139 12367 18646 21937 16001 19697 12675 12028 11783 21938 11796 12122 85030 26414 22029 16150 27056 13347 54131 12366 12123 22062 72193 12369 17869 21926 16002 12905 16151 51800 22030 12633 12050 18708 71609 11799 16000 21933 16476 12177 13368 12043 54123 12048 16364 18037 22059 26398 12370 11798 14103 22035 15201 14082 17210 12368 12125 26401 22061 Nod like receptor NLR signaling pathway%WikiPathways_20260211%WP1256%Mus musculus Nod like receptor NLR signaling pathway 59079 12675 16151 19697 26419 13844 26409 16150 21939 Mismatch repair%WikiPathways_20260211%WP1257%Mus musculus Mismatch repair 16881 18971 17685 19687 17688 17350 26909 18538 68275 Homologous recombination%WikiPathways_20260211%WP1258%Mus musculus Homologous recombination 67967 19361 12190 68275 27354 19365 69745 11920 623474 17535 18971 68275 18972 19360 Retinol metabolism%WikiPathways_20260211%WP1259%Mus musculus Retinol metabolism 63857 63954 11668 320092 19401 19378 67470 77974 19682 20148 232174 237636 56847 27409 16956 13106 19892 170752 20778 54200 545963 79235 20182 98711 67442 19659 20181 26876 20887 13082 12491 19411 235033 11522 20183 12904 12903 19771 19660 19662 218772 ErbB signaling pathway%WikiPathways_20260211%WP1261%Mus musculus ErbB signaling pathway 216148 56637 83961 320207 13869 23797 18803 12223 26419 13867 211323 13649 13866 11836 12015 11839 14388 13712 21802 20662 20779 14784 18183 13874 17869 20850 12575 26395 16476 15200 13645 13685 12928 18750 12576 12322 56717 15461 80794 70584 17973 26400 26413 14083 11350 100042150 Aflatoxin B1 metabolism%WikiPathways_20260211%WP1262%Mus musculus Aflatoxin B1 metabolism 110198 13077 14871 14862 13849 Mitochondrial gene expression%WikiPathways_20260211%WP1263%Mus musculus Mitochondrial gene expression 21780 15161 224481 15278 226169 66410 545725 14390 216151 26379 18181 213054 20683 19017 170826 17876 12326 12912 19055 Estrogen metabolism%WikiPathways_20260211%WP1264%Mus musculus Estrogen metabolism 12846 94284 13077 394436 20860 20887 18104 13076 394434 14857 22236 14862 13078 Polyol pathway%WikiPathways_20260211%WP1265%Mus musculus Polyol pathway 16548 230163 11677 20322 SIDS susceptibility pathways%WikiPathways_20260211%WP1266%Mus musculus SIDS susceptibility pathways 20271 11516 16153 21990 17161 20683 15205 12268 19712 15550 212139 13018 18095 20191 108015 21926 328572 625018 14461 16511 13195 12391 11998 11517 19017 170826 16917 11438 18044 16535 17172 19883 54006 15558 22355 13798 16193 22608 14462 22354 216343 15567 217946 15510 18992 260298 230857 14695 11835 14235 16194 12912 16535 14815 11859 19713 15208 27140 18033 18088 18935 11444 Fatty acid beta oxidation%WikiPathways_20260211%WP1269%Mus musculus Fatty acid beta oxidation 97212 11364 231086 66853 12896 11409 13177 93747 270076 15107 231086 11370 14571 433256 13382 60525 21991 14626 14081 67460 15450 57279 11363 12908 16890 216739 12894 12895 50790 14933 67717 12651 110446 74205 16956 Endochondral ossification%WikiPathways_20260211%WP1270%Mus musculus Endochondral ossification 11647 20750 14184 17386 11595 12166 16147 14182 16002 12161 16000 67760 21803 12283 17260 12824 23794 12399 19226 14172 12313 20259 12393 14173 20679 19206 18605 18747 16568 58250 13039 21808 11651 14634 208715 22339 17395 12406 12162 12577 20682 21833 20846 11504 14600 18792 17313 20851 12813 240913 16001 21821 18214 12020 58214 20378 18791 208727 19227 19228 20678 21859 Selenium micronutrient network%WikiPathways_20260211%WP1272%Mus musculus Selenium micronutrient network 14775 19215 11689 17708 14782 103711 19223 64292 21391 17769 98256 14776 56473 20363 75512 80795 22436 238505 76267 17709 12359 14778 625249 Folic acid network%WikiPathways_20260211%WP1273%Mus musculus Folic acid network 64292 19223 75512 56473 12411 26462 12359 17769 98256 14776 19215 80795 20364 14778 238505 11689 27361 14782 22436 50493 103711 14775 625249 Oxidation by cytochrome P450%WikiPathways_20260211%WP1274%Mus musculus Oxidation by cytochrome P450 13082 66427 72017 320997 109672 13078 266690 123956256 320635 110115 13115 72054 546726 13121 13123 13075 13079 232174 13122 545817 13124 74134 56050 244209 13116 13120 13077 102294 71519 81906 13106 13070 77951 18984 13074 104086 13107 109754 13072 13081 13076 GPCRs non odorant %WikiPathways_20260211%WP1396%Mus musculus GPCRs non odorant 14829 56696 99633 108068 18387 17201 12769 19218 208188 12777 12614 54393 18168 15558 20132 70839 54140 13051 11551 58861 15566 18441 67168 19228 319430 13349 225192 387349 14293 11555 14427 15465 17202 107934 14766 22354 20607 14365 57385 16867 19216 14367 12771 12000 114229 217369 13489 242093 15562 12672 57252 18430 213527 69296 11542 18442 140741 12311 99633 242425 20605 93746 13490 57253 387285 20608 18216 230777 12671 19214 22045 111174 14816 107221 94226 244701 319757 12669 14309 230775 110168 107831 18167 210198 12922 18101 69412 78826 14744 54598 13492 14652 246313 13610 11554 57265 11517 15557 387616 211578 11552 11607 99296 108073 11539 14602 15564 19220 381853 14370 387344 387355 210933 12773 319239 13491 18386 574402 53883 11608 13617 140795 320463 12273 65086 14368 216749 14062 229214 11609 59289 667992 53978 11549 233571 213439 21338 381489 238377 11541 15565 12801 140498 70086 170757 11540 12770 12061 14739 15560 233079 233080 233081 18217 12921 387353 17200 15563 26364 93896 12425 14428 232431 330814 12458 104443 57260 54199 13611 22355 14823 12776 14369 12802 227288 239283 387515 84112 22095 14371 71223 14064 14767 213788 13618 23796 17171 108069 14063 381810 12426 12765 12767 11550 11556 12775 12766 57811 387347 574417 226304 12768 20609 19222 52614 21336 237175 14715 23832 13733 80901 319229 12267 11553 18390 319387 236781 14745 19065 268934 14065 12145 13603 80885 243764 74191 353167 17773 26361 227289 19204 16995 15551 239336 12374 20606 64297 14366 12778 15550 13609 18169 17203 30044 13488 78134 15559 353344 14765 12772 108071 76854 57254 12062 226278 19217 21390 207911 108072 11548 21337 18166 58182 19219 15552 15466 17199 18241 14362 14527 GPCRs odorant%WikiPathways_20260211%WP1397%Mus musculus GPCRs odorant 258927 381413 233221 233919 83770 18389 14747 238725 259005 12209 259013 229323 493809 240888 80706 67549 14608 404239 14762 258697 258734 387345 68151 218066 18312 353166 319197 229357 338346 212541 258725 78249 215855 383563 215798 237716 54672 18328 224792 18307 387342 107173 18316 52710 227326 58245 14160 209513 14763 258585 404242 76206 14788 18322 110326 258478 406186 243979 233230 113850 381628 258769 215854 12057 22296 113845 258770 80910 18315 113848 27216 113846 209512 276742 78308 171469 241263 387354 258565 64095 64378 236798 259017 436440 24100 233231 241070 100129 381974 73010 258319 70693 78560 321019 277463 113851 258318 259012 258728 353346 503558 238252 70771 257898 112408 22297 229714 77596 245424 113847 387346 113856 329252 71862 83771 353148 269053 233670 269604 228228 404240 258573 387514 80978 387340 57272 113853 258362 319200 14748 435529 353165 81006 387348 235854 387512 387343 23890 83924 258327 258939 14761 18373 235256 113849 258566 70713 14539 14764 56861 84111 14760 80290 387511 258498 387351 56544 382045 11536 64450 68526 244238 257890 258869 404238 243270 258742 258310 381886 243277 211577 258581 217302 239853 239845 217143 258923 387341 258738 209776 387513 387339 107515 14738 18310 239530 387352 GPCRs orphan%WikiPathways_20260211%WP1398%Mus musculus GPCRs orphan 277463 78308 67549 107173 236798 319197 76206 68151 70713 58245 68526 52710 240888 83924 435529 224792 436440 217143 24100 Oxidative damage response%WikiPathways_20260211%WP1496%Mus musculus Oxidative damage response 18538 12262 12577 12260 12273 21938 15139 22031 12043 12902 12015 11783 338372 26415 12540 22030 12268 12575 13067 50908 50909 56196 13063 51789 12267 26398 67384 12263 12576 22029 18037 18033 21926 13197 26401 26414 22034 12259 12367 12018 12371 Dopaminergic neurogenesis%WikiPathways_20260211%WP1498%Mus musculus Dopaminergic neurogenesis 18012 18424 12577 13799 16917 22408 14633 11924 17701 13195 20848 11668 320092 13162 13798 18088 18227 21823 17172 19713 18742 214084 14179 18096 14472 15376 110648 14632 20423 20674 21803 IL 5 signaling pathway%WikiPathways_20260211%WP151%Mus musculus IL 5 signaling pathway 11909 20851 12028 16414 56637 16409 12929 56484 18708 15162 23921 18709 12983 216148 12576 19229 12445 16185 16192 20963 11689 18033 20416 18751 20677 13430 26396 16451 26413 14784 18035 15894 18783 12703 16476 20850 22248 16653 22631 18753 13712 12983 15461 16191 12402 30955 26417 20848 20111 107746 16452 12387 11651 15163 110157 19247 606496 11690 12229 110351 26416 15170 20846 22324 26420 18712 53378 17096 19353 Regulation of cardiac hypertrophy by miR 208%WikiPathways_20260211%WP1526%Mus musculus Regulation of cardiac hypertrophy by miR 208 14463 140781 74318 327987 14613 17700 MicroRNAs in cardiomyocyte hypertrophy%WikiPathways_20260211%WP1560%Mus musculus MicroRNAs in cardiomyocyte hypertrophy 22416 20848 26417 16878 16973 213435 54720 18751 19353 208727 79221 18607 16000 26419 26413 12675 12572 12387 16151 11606 13542 73181 56637 23939 18706 13019 26396 18708 18709 26398 18033 16001 53859 56233 12700 19877 107951 19091 18707 18796 56489 26416 14183 107589 110157 13614 16150 16195 57265 16974 26400 74769 18710 211323 13645 17876 19056 11652 21803 56717 14173 26397 225724 23938 230899 18780 30955 21926 19878 26395 18158 15184 11848 22418 14463 224045 11651 19055 108058 66513 26399 14362 12313 Glycolysis and gluconeogenesis%WikiPathways_20260211%WP157%Mus musculus Glycolysis and gluconeogenesis 235339 13808 20528 21991 20526 13806 56485 106557 18655 14751 103988 13382 18598 14719 14120 20527 13807 14377 56012 18563 18534 16832 212032 16833 68263 27402 14433 18746 55951 18642 14447 18597 18770 11674 18663 17448 56421 20525 14718 15275 11676 230163 18648 15277 14121 18641 17449 16828 70456 Iron homeostasis%WikiPathways_20260211%WP1596%Mus musculus Iron homeostasis 22041 14319 50765 14325 66438 64602 84506 21926 16193 69585 15216 16194 53945 16175 Cytoplasmic ribosomal proteins%WikiPathways_20260211%WP163%Mus musculus Cytoplasmic ribosomal proteins 20084 27367 20005 19896 11837 56040 22121 26451 19989 19988 27176 110954 270106 19921 19933 19934 19943 19944 19951 57808 54217 27050 16898 20103 20055 20091 20042 27370 26961 19941 19946 19981 67945 19982 20102 20104 20115 20116 100040298 27207 20054 54127 20090 14109 67186 269261 66480 319195 67025 19899 76808 108168140 268449 68193 19942 114641 68436 619547 66489 100502825 67281 67671 67891 67248 67097 68052 20044 16785 267019 20068 20088 20085 67427 66481 66475 75617 57294 78294 20111 20112 110651 58988 Glutathione metabolism%WikiPathways_20260211%WP164%Mus musculus Glutathione metabolism 23887 14598 14775 14782 16790 110175 14857 68312 14776 14854 14629 15926 14598 14630 14778 14872 75475 14871 625249 14381 14863 13479 68044 Apoptosis modulation by HSP70%WikiPathways_20260211%WP166%Mus musculus Apoptosis modulation by HSP70 21937 12371 12370 12366 14082 26401 19766 14102 12367 18033 193740 12368 11783 26414 12122 12369 26926 Acetylcholine synthesis%WikiPathways_20260211%WP175%Mus musculus Acetylcholine synthesis 13026 18598 11423 18597 18618 12660 12647 Mechanisms associated with pluripotency%WikiPathways_20260211%WP1763%Mus musculus Mechanisms associated with pluripotency 13990 12914 19696 13016 21752 12578 17246 12575 20841 11819 13865 20683 213742 17480 14175 81879 18109 12168 17128 18128 20130 22418 17344 19164 22018 13380 12622 18033 13590 19280 50764 13445 17191 17192 75560 108155 22196 59024 15182 21849 22632 56380 19821 26424 21414 104383 65969 22592 13197 328572 51869 226442 66830 11614 22764 17865 16600 13211 19712 59016 15161 18999 26417 21432 21386 15901 14465 18986 18451 14388 16451 216233 16195 16880 16878 11789 12005 16842 22773 94093 56717 11651 17869 12591 12443 20848 99377 15221 71950 20674 13194 22059 353283 19211 18707 26395 110157 15461 17126 21812 18119 51810 14182 12159 11477 17125 12550 12387 21415 16412 56637 13542 208727 269424 14362 16973 22416 19247 14784 22702 328572 22286 26380 13619 22772 104156 21420 18424 69890 56353 628746 21888 19664 58198 14281 54624 209446 81601 20662 16324 21803 17131 14030 20588 11545 13018 22097 17342 76804 104263 22715 16647 12367 65079 12505 26413 18103 21425 110147 54427 16367 16337 16333 20423 319757 77683 102060 17977 13017 18747 13435 13436 21418 20230 212712 77766 20750 59004 66894 12912 18140 26611 74178 14176 13164 231413 14797 18712 223775 18260 11909 15894 12189 22218 52463 20997 21331 14472 13864 22025 22668 252870 104248 23988 19877 19878 18752 103551 16009 57278 76509 64058 13139 15260 63913 15162 269275 93762 20833 20689 107932 15078 22589 93960 51792 18291 14566 11479 17765 19646 245688 52615 16468 18158 18160 69719 13347 14056 17127 14055 13626 233726 16211 57258 226432 20687 21750 15111 12934 20591 216850 381022 22289 17260 17261 17927 75788 20393 83814 15251 73693 16598 15201 13433 22083 235497 214498 66317 74766 19651 12566 19698 76893 17975 17089 21848 22160 332221 67155 18854 99982 234366 19697 20586 229542 66923 433759 116870 20466 12224 23942 76007 21886 One carbon metabolism and related pathways%WikiPathways_20260211%WP1770%Mus musculus One carbon metabolism and related pathways 214253 14780 20655 246277 212862 13361 13026 232087 14782 236899 75320 99712 20657 11720 67305 107869 14854 218865 13435 64918 17769 13429 18805 20656 75512 12651 14415 12583 14417 14711 12116 20425 68671 192166 625249 14776 14775 238505 14630 14778 229709 12411 74129 12012 108037 12660 22171 14629 18618 12035 14629 12036 14630 268782 14854 Kennedy pathway%WikiPathways_20260211%WP1771%Mus musculus Kennedy pathway 320951 99712 18618 12651 20397 19210 12660 236899 68671 75320 13026 214253 212862 27388 Heme biosynthesis%WikiPathways_20260211%WP18%Mus musculus Heme biosynthesis 11656 14151 19044 12892 15288 11655 17025 22276 22275 GPCRs class A rhodopsin like%WikiPathways_20260211%WP189%Mus musculus GPCRs class A rhodopsin like 258416 258501 20606 54140 12062 258605 11554 93690 258604 17200 258740 18169 257912 26361 258883 258173 23796 14608 74191 11540 57251 15550 13491 56858 258433 20609 13490 258589 259034 18217 20607 14309 64095 12772 212541 17199 15465 259036 56014 15562 21390 14427 258607 14429 19219 258333 18389 12209 14747 258475 14763 30044 194433 12425 11608 56015 18313 258776 12766 258597 76854 12672 13603 14765 257902 20605 15551 11551 12000 12801 12768 15466 11552 14761 14748 14428 18216 12061 19216 258046 11556 257959 11609 13618 14762 12802 17171 29845 258499 19204 80706 233571 258498 19214 170732 14291 11607 258500 15564 22045 12145 12669 15563 12765 17773 18442 18168 16867 81006 69296 11542 258242 15557 258594 14062 258310 12267 11553 11550 258497 14064 243764 20608 16995 258868 11549 54393 258430 258882 11548 17203 258811 14760 21462 258328 23890 14065 15565 12769 19220 15566 258434 18429 14294 12057 12771 84111 18441 12770 15559 14738 406176 140795 320463 18312 258603 19217 12773 66786 259037 258794 258269 84112 258826 18390 258415 18430 14293 18386 14290 18348 12776 258802 13051 56861 19218 14744 12426 54199 57811 58861 29849 19222 258323 259035 18387 15552 18101 69412 14767 15560 14063 19065 171469 18343 11541 18316 80885 59289 70839 11998 14539 258742 11555 18166 20132 18317 14764 18314 18167 233670 258276 258431 17202 57385 29846 12671 12273 14289 15558 12767 12774 12458 14829 258350 22095 17201 12778 Cell cycle%WikiPathways_20260211%WP190%Mus musculus Cell cycle 12545 12532 22390 12550 208727 21803 12531 17216 268930 12567 12575 12442 12649 12445 15185 12566 50496 71890 30939 19650 27214 242705 433759 18392 56150 104394 17219 15183 19650 19645 19090 66671 56452 140557 12427 18538 17127 12576 56233 12571 27401 50793 17218 12530 209091 50883 17246 12444 328572 11350 17120 105988 12428 56637 21781 12534 17217 218294 12235 12447 15182 12236 54610 12237 12544 22628 13557 15184 12448 26428 18393 13197 17215 12578 22059 13555 268697 11920 17128 18817 229776 13559 17220 17476 107995 26429 23834 245000 Hepatocyte growth factor receptor signaling%WikiPathways_20260211%WP193%Mus musculus Hepatocyte growth factor receptor signaling 107746 110157 215449 20779 14083 12928 19229 19303 14388 19211 15234 26396 218397 26411 17295 26395 109700 13712 109905 26413 18479 26419 18706 12929 20848 15461 20662 16476 14784 16412 330662 19247 26417 14281 Splicing factor NOVA regulated synaptic proteins%WikiPathways_20260211%WP1983%Mus musculus Splicing factor NOVA regulated synaptic proteins 12390 13822 225724 12558 66354 65945 16522 76707 16531 12361 26562 14406 26420 67972 18798 110351 13852 12325 54725 18007 12361 268566 13131 11804 16536 20911 269587 13823 12661 80883 57321 13640 14812 14810 11735 14806 18762 242425 13821 94332 17758 11603 12994 Complement activation classical pathway%WikiPathways_20260211%WP200%Mus musculus Complement activation classical pathway 50908 12260 50909 12259 12262 230558 17174 12263 12266 12279 110382 12274 12268 13136 625018 109828 15139 Ptf1a related regulatory pathway%WikiPathways_20260211%WP201%Mus musculus Ptf1a related regulatory pathway 18609 19664 18096 12387 15205 19130 18128 14165 18519 19668 19213 18609 Hypertrophy model%WikiPathways_20260211%WP202%Mus musculus Hypertrophy model 22388 13685 16177 18124 16175 15978 13684 22339 11910 21417 16478 17700 11487 16007 107765 56405 15200 15982 17928 16173 Heart development%WikiPathways_20260211%WP2067%Mus musculus Heart development 15214 22341 26413 17125 14179 14106 14463 12387 18091 13867 50916 19247 21388 18128 12168 57246 20893 17260 12180 12156 17300 12154 387163 14234 15213 387136 73181 16392 387161 18018 21385 22339 12166 20423 22340 14165 14465 20807 17128 15111 18019 109575 15376 12159 18741 18021 15110 Nucleotide GPCRs%WikiPathways_20260211%WP207%Mus musculus Nucleotide GPCRs 67168 11540 69296 11542 16995 11539 233571 57385 18442 18441 78134 11541 Neural crest differentiation%WikiPathways_20260211%WP2074%Mus musculus Neural crest differentiation 12162 11852 17863 16412 22408 21418 22771 18505 18509 13395 17703 17702 15221 20613 20583 22416 14365 56637 12387 21415 21413 14472 12006 12005 13544 13543 13542 12159 17125 15901 18128 13389 18132 18129 54485 18131 13388 15214 22160 20665 14173 15208 15205 19664 14182 14183 14184 65100 107771 20682 16392 12563 12558 12550 20678 23871 18033 241201 18034 18014 18935 14580 50914 50913 14618 17172 17342 18858 17528 17196 16869 16870 14179 14170 433759 15182 15183 208727 15184 15185 56233 70315 79221 170787 232232 13017 13190 12824 12815 12587 20890 15407 235472 94222 21389 15394 16873 21909 21419 140477 15110 Alzheimer 39 s disease%WikiPathways_20260211%WP2075%Mus musculus Alzheimer 39 s disease 234664 11820 11785 11487 23821 66340 19164 59287 226548 15925 17380 16956 11816 16971 14102 21937 14082 12370 15108 12122 12314 56398 12015 70405 80796 19055 19056 19057 19058 19059 70261 11491 19165 11783 12371 12367 20617 14810 12288 14811 14812 14813 14814 12289 54652 12292 14682 18795 18796 18797 18798 21926 16176 26413 26417 12364 20192 11938 11937 53313 13666 78943 226641 16438 16439 16440 12333 12334 22059 12569 18125 12568 17762 56637 12369 Serotonin receptor 2 and STAT3 signaling%WikiPathways_20260211%WP2079%Mus musculus Serotonin receptor 2 and STAT3 signaling 15558 16452 14682 20848 SREBF and miR33 in cholesterol and lipid homeostasis%WikiPathways_20260211%WP2084%Mus musculus SREBF and miR33 in cholesterol and lipid homeostasis 20787 19017 50721 15357 93759 56717 22259 19013 723897 94112 20788 16835 Serotonin and anxiety related events%WikiPathways_20260211%WP2140%Mus musculus Serotonin and anxiety related events 15558 11838 15560 15550 14281 56193 19055 18751 18802 14814 192167 12921 12918 Serotonin and anxiety%WikiPathways_20260211%WP2141%Mus musculus Serotonin and anxiety 18802 56193 18976 14816 193034 18751 12323 14265 12918 19055 13629 14394 11838 15560 14281 15550 11549 11838 13629 15558 BDNF pathway%WikiPathways_20260211%WP2152%Mus musculus BDNF pathway 18791 12064 18212 12043 327826 22059 18815 225724 12912 19353 12028 20416 12540 18053 18787 12064 18815 Striated muscle contraction%WikiPathways_20260211%WP216%Mus musculus Striated muscle contraction 21925 21956 12373 13346 21955 17897 21924 22138 13405 22003 21952 17996 21953 11465 17868 17879 22352 17883 11464 22004 11474 233199 17884 17906 326618 11472 109272 21916 17896 17885 17929 17888 98932 66106 21957 21954 11475 17901 17930 140781 59069 21393 11459 60595 71912 Purine metabolism%WikiPathways_20260211%WP2185%Mus musculus Purine metabolism 102216272 108143 18605 75686 209558 633979 73532 73532 18605 68870 215446 18770 18573 14198 242202 20020 56520 69833 667034 18577 50773 16434 20021 110385 171567 667034 210044 23984 18950 18576 14450 23959 225600 18102 18102 230718 27369 75533 76952 18968 70881 171567 18746 18573 18968 66355 67486 18577 218461 72090 76952 18969 15452 230718 230103 11636 215446 18574 11637 382985 67967 67710 103850 18950 70881 54611 15452 26939 12496 76974 72090 69745 16434 11512 18746 66358 238871 107569 20016 20020 18969 229665 78929 64424 18583 18974 18574 66401 215446 19139 71701 18950 11514 20016 667034 54369 229949 667034 230718 70881 231329 18973 241489 107569 108147 69241 16434 18584 14544 11566 18588 171567 105446 239134 54369 218461 66136 18103 54195 56520 18583 229589 667034 234889 18575 245650 20133 11821 20018 66401 67464 56520 94041 18103 72090 18584 103850 20135 70408 67054 11486 23959 18973 74414 11821 66491 66979 11514 54611 14450 230718 18972 19075 76952 12495 69745 382985 224129 18971 18950 20022 18582 79059 229363 23972 79059 207728 78801 54369 78801 76952 23972 14919 72090 11565 18102 11515 11821 67967 20135 15452 14450 20017 215446 11564 22262 14923 103850 11636 20022 18770 20018 60596 67486 69241 11486 23959 18103 14918 16434 432530 59001 18770 74414 11639 103850 54369 23971 23918 19075 13178 66979 18578 12497 20133 110385 12495 215446 12495 20019 75533 23918 66420 238871 56520 210044 79059 271639 75456 14917 59001 53893 78929 50773 231903 110639 66491 50773 20017 69920 18102 667034 76952 103850 67005 229949 76025 69870 76952 23959 12497 79059 70428 75533 19076 75533 12495 18974 29863 11534 224129 72157 18746 69870 67464 107569 18746 69833 218832 18160 11639 18950 66681 18585 76025 11515 70881 107569 50773 50773 12499 20021 104110 18950 72090 230718 18578 70881 12495 72090 18575 64424 11513 230718 22436 207728 16434 66136 245841 20019 19076 50773 11717 12495 104111 107569 11564 23917 18972 23959 103850 67005 110855 18770 23984 67054 328099 26939 215446 70408 171567 18576 11637 218832 70428 432530 231327 245841 104110 12499 23959 18971 109674 66420 66401 104111 14923 71701 67065 70881 69920 78600 107569 231329 11513 67710 271639 18587 29863 67065 23971 11512 108147 241489 74167 237823 18103 100862375 68695 Cytokines and inflammatory response%WikiPathways_20260211%WP222%Mus musculus Cytokines and inflammatory response 16175 16176 21803 16153 12504 16187 15962 16189 16163 12977 16196 15978 16183 12985 21926 16168 16191 14825 330122 16193 16160 16156 12981 16159 18590 15977 14969 Macrophage markers%WikiPathways_20260211%WP2271%Mus musculus Macrophage markers 12522 12475 12514 14066 93671 12524 16149 23833 19354 17105 Chemokine signaling pathway%WikiPathways_20260211%WP2292%Mus musculus Chemokine signaling pathway 13051 216869 66102 14710 20301 100039863 100040048 12929 14706 20299 18708 22325 56484 18747 210044 20295 56637 57349 12928 14700 18751 14678 19354 19353 16452 12540 110157 277360 20303 14697 18709 14707 12776 20306 18033 12675 14083 12988 21844 14695 18710 18798 94176 109880 12770 20308 20312 17096 18749 224129 12771 23832 19303 20416 12777 66066 56744 16453 18479 73178 20311 12927 14702 19395 20846 20418 74769 20290 18707 12775 606496 12768 110355 22324 20847 20292 26385 18797 17329 216148 320207 80901 57266 20307 20293 14679 20851 12773 271849 14708 12767 14688 26413 18762 16428 14784 18706 19877 19108 19878 19697 20662 12766 14701 100503710 14709 11513 109905 16653 16963 20663 18796 11652 12774 12772 20315 14825 17969 14699 15945 56221 14772 12458 20302 23797 12769 18795 16150 20305 15461 56838 93742 24001 20296 11651 227288 20309 57257 18176 14191 19229 14696 22376 24047 18762 20300 26417 104111 24013 104110 11514 20301 100039863 100040048 64337 11848 140580 15162 55985 14677 18035 20848 12145 541307 11515 26395 18753 14693 20304 18036 14773 215449 109689 18829 20310 16151 432530 20297 14704 12765 11512 30955 PPAR signaling pathway%WikiPathways_20260211%WP2316%Mus musculus PPAR signaling pathway 235674 19015 69050 19016 22190 74551 666168 13124 22227 26457 15360 13117 20182 11832 20250 11430 13118 30049 329065 22259 20181 328845 14080 13119 20183 20182 216739 57875 104086 74205 12140 11364 12895 78070 20181 277753 14077 100040843 14079 50790 13167 26458 26569 11807 12491 26457 14080 17436 11450 11814 433256 11770 19013 56473 20183 13122 18830 14933 103968 26459 80911 66113 93732 18534 12896 14081 16204 20182 83996 108078 26569 230639 12491 83995 225579 435802 94180 20280 20249 16956 16202 11806 14626 14077 20183 12894 20181 20411 11770 16592 74147 18607 11363 113868 Fatty acid oxidation%WikiPathways_20260211%WP2318%Mus musculus Fatty acid oxidation 15107 93747 11370 11409 52538 15107 93747 17777 11364 12896 12894 214663 G protein signaling pathways%WikiPathways_20260211%WP232%Mus musculus G protein signaling pathways 19088 14700 29863 104111 224129 14701 66066 56399 19057 11640 19085 14683 18753 14695 18577 18574 14682 14681 238871 18751 20130 14675 238276 14687 104110 218461 18176 64337 14699 14693 19084 14672 18755 19055 14677 12313 18749 19087 14697 16519 18797 432442 14674 11512 11642 18573 18575 210044 14680 18760 75292 11515 238161 432530 75547 14676 18584 83397 11848 11643 14679 219181 14710 18761 110385 14709 18754 14708 18752 14688 18750 18759 14707 14704 15461 18762 16801 56697 11514 11513 18747 18578 16653 18583 100986 14706 14673 16438 20544 14678 GPCRs peptide%WikiPathways_20260211%WP234%Mus musculus GPCRs peptide 12426 22095 21336 12776 12770 18166 26361 12061 20609 12000 17200 19065 12267 14309 18167 16867 18430 12773 12766 12145 12769 13618 12768 18386 17202 14429 18169 20605 17199 12273 11609 18390 20606 18387 21337 14428 22045 18217 80901 18101 69412 20608 14829 54140 12765 13051 17203 208188 17201 13617 12062 12767 14294 12774 12777 18389 12771 14427 12458 11608 11607 18168 12425 18216 12775 12209 14293 12772 21338 14715 20607 miRNAs and TFs in iPS Cell Generation%WikiPathways_20260211%WP2375%Mus musculus miRNAs and TFs in iPS Cell Generation 68479 70052 53607 53817 18999 20674 75062 Osteoblast signaling%WikiPathways_20260211%WP238%Mus musculus Osteoblast signaling 19226 18383 18595 21943 19228 64654 12842 218103 12097 18596 Alanine and aspartate metabolism%WikiPathways_20260211%WP240%Mus musculus Alanine and aspartate metabolism 14415 268860 226414 11484 109900 76282 18563 11898 14718 11611 14417 14719 11564 12908 107239 Spinal cord injury%WikiPathways_20260211%WP2432%Mus musculus Spinal cord injury 18053 69583 16995 24099 19283 18610 16994 18845 121021 16423 22695 14130 381833 19262 16176 18126 21926 15370 16189 12227 12566 18125 16183 16193 21898 14281 21803 13653 17381 15978 17196 68585 15139 14825 11829 11846 13838 13642 15945 12450 17395 13004 20562 20563 20564 18208 244058 12772 16177 16175 20310 20296 53357 18784 18780 16952 15894 20344 259277 14580 12567 21336 13559 19645 18750 13555 26413 12443 17869 13197 26417 12367 22059 58250 13003 12826 233781 12824 11595 12032 20682 14810 22352 19055 14432 14225 17136 11848 11853 11852 19878 18377 65079 18733 50490 387217 12534 14573 20358 14609 12064 TNF alpha NF kB signaling pathway%WikiPathways_20260211%WP246%Mus musculus TNF alpha NF kB signaling pathway 23881 69721 14113 18036 15516 72508 230233 544963 57751 12366 56489 16709 328949 19698 16648 16151 12389 20340 26401 19179 19182 12335 26410 17846 11651 13001 22627 20016 103583 18567 15519 56637 21926 26965 56456 19766 19697 71833 66997 211550 21938 22032 12905 19052 12995 22030 16650 80859 67891 18035 22196 26572 74256 22682 245841 11797 22629 109658 22034 68652 70247 56532 17463 22031 21941 446099 14082 12234 18033 21937 17218 23938 71966 192176 18616 15182 64424 21353 22631 53859 14886 14229 68052 19946 22033 219158 12367 22628 333654 56480 57783 26961 67384 18034 73086 20587 14694 18037 26405 231130 76784 19696 12675 68094 11652 26885 21934 20018 21929 54401 14084 57376 18854 12633 192656 27215 12370 11796 22036 53376 21402 16150 12539 19708 15507 66724 22029 192170 20586 76589 14388 433759 23997 23980 211651 229615 16535 26406 18747 12914 19181 70333 20779 15185 18762 216150 17220 320795 108086 20588 22218 18201 27207 14083 11647 71609 20019 12051 22026 77045 13000 22123 66413 12369 226525 20017 236733 13728 56399 18789 20846 16647 13205 19988 18637 223453 72416 19247 56407 19173 66513 Mapk cascade%WikiPathways_20260211%WP251%Mus musculus Mapk cascade 26416 16476 18176 110157 26406 26401 26417 13712 17756 26398 15461 26404 26414 26396 17196 29857 26399 20469 26413 19414 20130 11836 16653 26405 109880 26395 26397 18797 Androgen receptor signaling pathway%WikiPathways_20260211%WP252%Mus musculus Androgen receptor signaling pathway 12534 433759 11835 20779 27057 14815 15469 19645 104156 59004 13982 12017 97165 110157 20602 16476 12317 56218 217127 20848 11651 56736 12447 30051 19822 56424 12393 16195 223870 18987 23957 22196 11909 16000 17128 18193 12859 12387 14797 68098 16193 14884 12389 67655 56705 22294 66671 19211 72993 14200 98053 22215 108767 19697 13649 14600 17344 22059 268903 214230 12572 328572 11739 192176 81000 15259 26395 12362 22634 17978 12189 13983 22026 21815 229615 12531 83995 12370 21674 12367 12369 193740 18813 26423 225115 11614 12914 12443 17977 17246 22629 19384 19303 56469 21804 17979 17127 170758 20683 81601 18986 26413 68705 107951 20466 19183 232286 12394 12539 Primary focal segmental glomerulosclerosis FSGS %WikiPathways_20260211%WP2573%Mus musculus Primary focal segmental glomerulosclerosis FSGS 16410 21898 12323 11651 13429 67703 16416 22330 16449 243911 17973 12476 13039 19277 16776 13380 14360 18793 14083 54139 22370 22630 104027 21803 11603 12488 16691 170484 16779 54631 18803 12576 12946 18504 27205 16917 71602 12492 14107 192897 12830 12577 17380 22352 12575 74055 60595 17886 54380 22431 70435 22068 18538 17345 12558 12737 12828 12829 110829 12519 18128 12387 16974 16973 21894 16202 16412 16400 13138 57342 22288 TGF beta receptor signaling pathway%WikiPathways_20260211%WP258%Mus musculus TGF beta receptor signaling pathway 12234 21813 13018 13559 11910 18519 16477 17260 216080 108058 21417 19877 16476 19651 18046 54601 24136 71770 13805 17127 21814 21402 218210 217232 12567 104394 12393 12387 19645 12575 21812 19087 66354 26416 15228 52206 18045 14106 17131 216869 66313 69957 56438 75901 17126 16842 26399 21781 21803 68999 22062 22601 17869 12443 26965 22337 20683 59008 230597 69150 20482 56317 12389 21809 103573 14225 18708 14272 17128 75788 12505 18709 99152 26754 386655 12534 17344 13163 11909 23871 21815 12914 71728 14281 76793 21808 11835 72183 20869 14282 227720 18753 26419 19650 13542 56371 15405 16478 18751 17130 66513 52563 20481 26397 328572 66105 211586 12005 20901 15481 76630 93742 16211 13132 22218 15239 12442 13982 17258 12530 56550 54709 12006 19085 15529 12571 17222 56469 67804 12447 26409 56484 11482 56440 18044 17977 67903 68015 56458 59079 12566 71978 433759 12323 12322 12325 22059 15378 20692 12705 Delta Notch signaling pathway%WikiPathways_20260211%WP265%Mus musculus Delta Notch signaling pathway 18128 18129 18131 18132 13388 54485 16449 16450 19164 19165 208117 66340 59287 11487 11491 56637 18222 16396 11820 18223 18708 18709 11651 18550 12805 18133 14357 17172 328572 22059 16848 17305 140484 21402 50754 15213 270118 433586 103806 66354 20602 20185 433759 66935 60406 15182 20466 15205 20848 16452 19697 18035 15214 21885 17127 17128 22632 12566 16842 17260 26965 27401 21423 26417 26413 57750 14199 19763 16656 56381 17125 55927 22761 17137 12804 12803 15208 16818 16476 19664 13645 13649 Ovarian infertility%WikiPathways_20260211%WP273%Mus musculus Ovarian infertility 12167 19116 14309 16867 22788 13404 11920 17350 17687 14566 22787 20597 13164 14612 16322 17127 18667 13983 22337 26423 21374 20185 268903 13653 12608 19217 12576 12444 12567 13075 319565 B cell receptor signaling pathway%WikiPathways_20260211%WP274%Mus musculus B cell receptor signaling pathway 13712 15184 18021 14784 12444 26413 19058 11909 77799 18719 76709 12483 14389 19697 12042 218397 22324 107746 18604 72508 83490 13448 18718 18760 14388 68089 56743 18019 56233 20846 19264 12371 16439 12572 12571 15162 30955 16822 110157 14360 11867 26377 18803 17164 19645 66713 20848 12369 12518 22637 12912 208650 15163 26395 19247 16151 20111 117150 18709 68119 76108 18753 12053 16331 20963 12478 16150 12387 109880 14083 242248 12229 19696 56458 27261 77590 12902 12927 12929 17096 108723 12567 16438 18751 83436 26411 18720 11651 20663 12445 23921 18003 381290 56792 108083 12675 12125 26396 24055 12517 12928 18035 26419 240168 18754 67603 20662 15170 12988 12143 16818 12566 14886 11848 12028 225724 16476 18018 22325 18708 21682 319520 14130 74117 19229 234779 18761 12520 101476 17973 606496 16428 18607 22376 56637 15387 12402 26409 19253 12507 20104 12043 20416 72699 26417 12428 56378 15985 19055 67771 17060 26416 12447 19056 18717 Focal adhesion PI3K Akt mTOR signaling pathway%WikiPathways_20260211%WP2841%Mus musculus Focal adhesion PI3K Akt mTOR signaling pathway 12826 22084 53867 21828 19116 20662 12831 16420 105083 16453 16186 319480 12815 16780 14784 329278 20869 14599 16188 13857 16404 16409 12843 216505 15891 12832 18414 94216 21827 16398 16773 12824 12829 12985 192897 16402 16775 320910 381924 16416 16776 14083 12643 213119 81877 16400 12842 16403 13856 16410 16772 22371 12825 23797 16411 16414 16190 16399 12986 15976 23928 16197 21826 16421 15965 20750 14268 74747 12814 16401 16452 16451 22370 15962 15964 11651 74769 18707 14600 16194 12845 226519 16779 16185 18706 16774 16184 19211 16777 19699 75669 12827 64930 16412 241226 16407 104099 12834 16419 21825 16408 11652 18708 18709 16782 21923 15975 21960 320207 13636 14164 14166 14165 13637 13645 14167 12977 11602 11601 11600 22339 13638 13639 13640 14169 14168 14170 14171 14172 14173 14174 14175 14177 14178 14179 14180 14205 15234 16000 16333 16334 17311 22341 22340 18591 18654 18590 18049 54635 56636 67112 71785 80857 80903 14183 16542 16337 14184 16001 16590 14182 13836 13649 12978 14186 14254 14257 18053 17295 18595 18596 21687 67605 15967 15968 15969 15970 15972 15974 15977 16183 18413 19109 230396 404549 12669 14745 14062 243764 381810 53978 65086 67168 78134 14693 14688 100503710 14696 14699 14700 14701 14695 14702 14704 14706 14707 14708 14709 14710 64337 66066 30955 18176 16653 15461 72149 12283 69008 105787 108079 56716 19744 56717 74370 15251 22241 74343 12539 15516 98432 21432 18607 100039815 19053 19052 100039830 21770 225849 72930 73699 19054 235542 26931 26932 269643 51792 52432 226849 59032 15519 22027 244650 17763 27379 27380 110157 26396 26395 26413 26417 56637 56484 56458 16150 12015 12371 17246 16151 12576 12575 11909 12913 12912 11911 208647 208677 12915 26427 78284 231991 18127 57915 17274 59021 19325 19326 68365 20528 20525 20527 20526 19017 14936 232493 18640 18639 170768 270198 16890 20787 15375 107476 15568 18125 18126 13819 53417 58988 13685 75705 72508 20104 13684 26987 218268 240752 18704 18705 16367 16370 16369 384783 Gene regulatory network modelling somitogenesis %WikiPathways_20260211%WP2852%Mus musculus Gene regulatory network modelling somitogenesis 14179 21389 382089 17293 13838 84653 15205 16848 18128 13388 22416 White fat cell differentiation%WikiPathways_20260211%WP2872%Mus musculus White fat cell differentiation 22410 13591 20787 12606 12608 14013 19883 13198 12912 54131 20851 66277 12224 14461 21415 94187 13654 14462 11819 19016 22259 12609 12385 16600 19401 56458 20850 21887 16333 14815 16364 16598 Notch signaling pathway%WikiPathways_20260211%WP29%Mus musculus Notch signaling pathway 19664 16449 433586 14357 15182 13544 11491 13017 18131 103806 13543 13542 66935 59287 226548 19668 18128 20602 18222 209200 13388 66354 19165 54485 18129 18132 12914 80904 74198 15205 18519 207521 16848 433759 16450 19164 13016 13389 17305 18223 21926 19719 19208 208117 14534 15208 p53 signaling%WikiPathways_20260211%WP2902%Mus musculus p53 signaling 11920 50883 245000 12649 12578 17246 17248 22059 12575 12443 12444 12445 12567 12571 12447 12448 12566 55948 67874 268697 12442 209091 434175 12534 13197 17873 23882 29870 14102 57913 12370 12122 12028 58801 170770 13663 66940 64058 22401 20437 20438 13063 13067 11783 12371 12367 16009 16000 18787 107831 12521 21825 20724 107986 382985 20135 140742 230784 75747 19211 22084 68428 26374 68098 12450 12452 53892 22062 miR302 367 promoting cardiomyocyte proliferation%WikiPathways_20260211%WP2904%Mus musculus miR302 367 promoting cardiomyocyte proliferation 15235 50523 68473 22601 Mecp2 and associated Rett syndrome%WikiPathways_20260211%WP2910%Mus musculus Mecp2 and associated Rett syndrome 20185 17932 18996 11813 14175 12064 18015 20604 27528 53618 17257 18992 22608 14174 13006 14810 17260 21354 268859 12799 14056 14431 18387 622434 20466 20683 14415 270627 59013 13007 13395 57810 17932 12609 17196 12053 14409 13018 20687 70767 13555 19712 17136 14173 26913 52463 98758 22608 12912 miR 222 in exercise induced cardiac growth%WikiPathways_20260211%WP2928%Mus musculus miR 222 in exercise induced cardiac growth 12576 219150 15258 15257 Electron transport chain%WikiPathways_20260211%WP295%Mus musculus Electron transport chain 11946 230075 11958 11740 226139 110323 66152 12864 57423 28080 67942 66377 11947 68375 66594 66091 20523 72900 67130 17709 66218 407785 66694 17991 17720 17706 595136 12858 67003 11957 67680 17708 20463 75406 12861 74011 17993 12865 12857 27425 22229 66576 66108 66495 100041273 68194 100042503 12866 17722 68055 66945 17717 70316 66142 22272 11739 67530 17721 66414 52892 66925 11983 66916 54405 22273 66046 12859 17705 17710 68349 12868 17716 17995 66052 228033 12862 20930 227197 66416 17719 71679 68197 68198 226646 66043 68342 12856 17992 68202 11950 67126 11949 78330 67273 22228 17718 225887 17711 22227 IL 7 signaling pathway%WikiPathways_20260211%WP297%Mus musculus IL 7 signaling pathway 12125 12028 16362 20416 20844 12428 17829 14360 17096 20846 17210 20850 11651 16186 12567 208650 15461 12444 20662 16451 56458 26396 19229 26395 384783 16197 12402 18708 110157 12566 12143 12015 20848 26413 16453 16367 26417 19645 56637 14784 20851 67300 56484 56324 G13 signaling pathway%WikiPathways_20260211%WP298%Mus musculus G13 signaling pathway 20166 320795 12632 52428 11848 18643 16801 24068 14674 544963 29875 18707 11857 74769 59009 16885 53311 19353 51789 18481 18718 26414 12313 73178 18709 19046 22376 26407 17901 12704 14570 19877 13367 18706 12540 72508 19878 12631 Histone modifications%WikiPathways_20260211%WP300%Mus musculus Histone modifications 107435 433759 15182 77683 110147 Translation factors%WikiPathways_20260211%WP307%Mus musculus Translation factors 22384 13628 13690 224045 217715 26905 19106 13629 217869 55949 20918 68135 16341 13631 16418 13667 225363 13681 13682 13688 18458 13669 66656 13664 75705 13685 208643 78655 13665 66085 26908 276770 53356 108067 13684 209354 54709 56347 218693 230861 13627 18459 55944 108112 13666 67160 15467 67204 27979 mRNA processing%WikiPathways_20260211%WP310%Mus musculus mRNA processing 20020 74111 18139 68035 110957 22184 66679 237073 19847 20822 101943 207920 15382 67579 66055 24128 15547 20658 29813 234373 13206 66492 56417 20462 66164 109729085 67053 24014 117903916 27366 109075 66405 76167 72160 21744 12877 24018 75420 19848 19941 27041 68219 19653 69597 19826 74326 50926 102462 50911 57320 76938 76572 53610 67671 67456 19989 20624 66704 319695 20641 234733 53607 93728 53356 69207 20638 14030 20595 241490 66446 228410 54127 71713 246730 243272 20005 216578 70616 19106 321006 268859 72567 56031 69724 19845 67248 19357 23879 94191 71514 233908 231769 244631 100336 70233 235402 66585 66475 18789 108014 19657 229279 13205 12021 70052 58203 13164 80912 19134 68379 14007 140486 104307 56381 67842 19934 67949 19844 56190 192170 217337 56195 224344 68879 68278 384281 66185 18458 72935 15568 20630 67337 20853 20637 20639 17184 12748 13046 56009 66983 68598 20826 104721 338351 53890 12828 14962 319322 19862 115489655 66230 68092 13682 13211 27225 319586 56194 67936 108013 19017 72459 218543 52874 68172 20646 71713 70439 110809 107951 229279 77604 67197 83675 115488065 115488060 19842 18938 20090 57317 217207 75710 19844 320158 98985 68165 16201 15387 21843 239188 67418 77411 52521 192159 30959 23962 72735 98685 68479 246277 23983 69639 67434 20817 26961 353258 236732 57294 27275 27993 50783 19656 11428 22384 53379 230257 83410 66892 71766 170826 102857 21357 245945 193116 69192 269261 70044 12696 66599 230721 230603 15572 12189 67120 67025 229663 20821 19383 13690 272009 20975 15388 76626 26919 70930 27979 67710 67920 20823 77134 15469 16865 22034 52202 26987 19951 209224 67427 67465 381626 207181 13684 215615 53817 140488 51796 53975 18521 56758 72662 27756 78784 56215 53319 246727 231413 66094 20044 68272 108121 102414 19663 70767 230908 20088 22185 12750 64340 15571 20383 109095 11640 269061 69207 20826 19654 21752 75062 67667 54614 98758 213236 60365 51810 56316 11992 56258 56516 18459 20222 115488065 115488060 19842 20747 170722 16589 54451 11739 19205 27058 22380 14359 107686 23960 76897 217351 67010 19655 170791 66810 19935 74484 100861987 81898 69408 114896 53621 67959 71684 18542 51786 15569 20102 107701 224902 232089 230861 76846 67229 94230 13722 20384 68195 13680 11499 66419 20815 69878 66645 66660 66384 19921 68052 14265 59093 78304 73826 56335 67039 27998 72290 14208 72397 74213 106583 72054 246728 67390 100121 171190 59013 83410 67897 208606 13209 19652 100043257 75388 24067 24061 15468 56403 67889 80913 70248 21841 19317 13204 68011 76522 67207 71973 76938 19848 108657 380773 18670 68581 20813 100502825 67281 13207 15381 208718 56200 14105 14113 20382 54196 23961 67543 15384 53609 59092 67958 52513 17690 20462 208922 57837 11991 30947 56275 19845 108062 20238 20643 22099 21681 76183 67332 76936 67996 20115 54188 68744 66125 22608 218543 17975 27632 225027 56878 27207 20104 18148 192119 209003 53791 68981 67225 19656 20924 83486 20492 93871 67444 17876 12747 72692 56522 93686 Glycogen metabolism%WikiPathways_20260211%WP317%Mus musculus Glycogen metabolism 19309 19053 102093 232493 225849 68961 26931 12313 18679 269643 110078 216558 14936 606496 235542 27357 51792 12315 26932 19052 21770 72930 77559 226849 12314 110094 71978 56637 18682 73699 74185 72157 110854 110095 Eicosanoid synthesis%WikiPathways_20260211%WP318%Mus musculus Eicosanoid synthesis 11690 19215 96979 13479 19223 18780 11689 21391 19224 14598 53357 11687 11688 64292 16993 19225 17001 67452 11684 GPCRs class C metabotropic glutamate pheromone%WikiPathways_20260211%WP327%Mus musculus GPCRs class C metabotropic glutamate pheromone 14816 108071 108068 108069 14823 268934 108073 108072 12374 54393 242425 93746 70355 64297 232431 Fatty acid omega oxidation%WikiPathways_20260211%WP33%Mus musculus Fatty acid omega oxidation 26876 13106 11529 13077 11668 320092 11669 13076 11522 Fatty acid biosynthesis%WikiPathways_20260211%WP336%Mus musculus Fatty acid biosynthesis 14104 93747 433256 111175 52430 107476 52665 50790 20249 60525 67856 104112 74205 15107 100705 14081 18563 52538 26922 67460 216739 51798 ESC pluripotency pathways%WikiPathways_20260211%WP339%Mus musculus ESC pluripotency pathways 14368 23797 13544 66713 17125 56637 17129 17869 15461 12166 109880 18590 22415 14164 17131 22419 80903 18591 14177 14170 11477 14182 26395 12387 14366 67112 13542 16451 12168 16476 14165 18707 14180 14370 20848 20662 80857 11652 110157 14166 22421 14371 16195 14184 22418 23939 57265 14171 14367 93735 14172 14369 14362 13649 17246 22409 14186 14183 18595 26413 18121 11836 56717 17128 22422 55994 26397 20363 16878 16880 22413 23938 18709 16973 22412 12005 13712 14169 22416 12167 50772 19247 64654 14176 14388 19211 22411 14784 13543 11789 11651 21405 22417 17130 14173 22408 225724 14167 56636 22420 13645 29857 14365 22410 18596 14281 14174 14168 26399 26396 14178 12159 14179 353283 14175 22414 16974 p38 Mapk signaling pathway%WikiPathways_20260211%WP350%Mus musculus p38 Mapk signaling pathway 17164 14784 22030 15507 20416 26399 338372 19353 21812 17261 11909 20846 12912 26408 17346 26409 19766 73086 26416 13712 17187 15461 12540 15312 18783 26398 13198 19417 21808 13163 26401 17869 71609 GPCRs small ligand%WikiPathways_20260211%WP353%Mus musculus GPCRs small ligand 17773 12802 19216 19217 14739 19219 13610 13609 12801 21390 19204 14745 19222 19214 19218 13611 244701 19220 Fatty acid beta oxidation streamlined %WikiPathways_20260211%WP3588%Mus musculus Fatty acid beta oxidation streamlined 14079 97212 12896 11364 231086 15107 14077 13177 11370 433256 225579 11363 14081 57279 216739 12894 14080 12895 12491 12140 50790 11409 67460 110446 11770 93747 74205 26457 26459 26458 26569 26568 ApoE and miR 146 in inflammation and atherosclerosis%WikiPathways_20260211%WP3592%Mus musculus ApoE and miR 146 in inflammation and atherosclerosis 18034 11816 19697 387164 20375 16179 21898 22034 24088 Tyrobp causal network in microglia%WikiPathways_20260211%WP3625%Mus musculus Tyrobp causal network in microglia 27060 99586 67742 16164 14775 16409 668218 76448 80719 66824 105855 20514 338355 67963 66102 22177 15284 12504 239273 20540 245945 54519 12262 16414 216991 217203 12332 20850 56501 20111 20750 208647 12193 12399 56193 224109 17095 16950 12266 17970 238875 12493 21812 330217 12523 16411 78416 15163 16154 16923 231162 21938 50778 16173 57442 108735 17132 218454 Microglia pathogen phagocytosis pathway%WikiPathways_20260211%WP3626%Mus musculus Microglia pathogen phagocytosis pathway 15162 12259 22177 20963 18708 83382 58217 14127 14129 16409 83433 58218 16414 17096 15170 234779 16797 19353 19354 170758 22324 22325 57257 105855 11867 17972 17970 17969 13058 13057 12260 12262 30955 18706 18707 74769 18709 225326 18704 104709 18710 Lung fibrosis%WikiPathways_20260211%WP3632%Mus musculus Lung fibrosis 269400 20310 20750 224897 14164 20303 17131 14219 74108 20296 20482 21926 20387 16193 13614 13717 12985 23892 109620 21752 17257 20309 108689 12310 21802 16163 16176 12771 20304 18590 20292 50770 14173 17228 16191 13645 21857 16160 12162 18591 19288 18024 17395 14178 74180 12608 70086 15368 17390 15234 20389 12772 16189 12981 244548 18792 58909 20302 17750 16000 21803 Parkinson 39 s disease%WikiPathways_20260211%WP3638%Mus musculus Parkinson 39 s disease 107508 13195 13162 22223 50873 20617 21823 66725 68943 57320 64704 13063 14763 18951 67847 22187 22201 74153 22195 56791 140499 67128 22213 56228 20239 229521 12447 12448 29857 19094 26416 26415 12368 12371 12366 13063 12369 12367 11783 Ectodysplasin A signaling in hair follicle development%WikiPathways_20260211%WP3652%Mus musculus Ectodysplasin A signaling in hair follicle development 18033 19698 18034 19698 16994 18033 13608 19697 234130 66042 19697 171211 13380 14632 19206 20423 13607 13607 Novel Jun Dmp1 pathway%WikiPathways_20260211%WP3654%Mus musculus Novel Jun Dmp1 pathway 13406 11840 16653 16477 26413 12578 110157 17869 12567 12443 13555 19645 23871 26395 23872 16476 22059 17246 20130 18176 15461 11836 109880 26396 26417 14281 BMP signaling pathway in eyelid development%WikiPathways_20260211%WP3663%Mus musculus BMP signaling pathway in eyelid development 14165 14183 16324 21802 20423 12159 20377 17125 17129 17128 18741 56811 17300 14234 18128 26401 26420 16476 13649 26417 Hfe effect on hepcidin production%WikiPathways_20260211%WP3673%Mus musculus Hfe effect on hepcidin production 15216 71753 69585 84506 12161 17131 15901 Factors and pathways affecting insulin like growth factor IGF1 Akt signaling%WikiPathways_20260211%WP3675%Mus musculus Factors and pathways affecting insulin like growth factor IGF1 Akt signaling 17127 19017 56458 17126 19079 17700 21950 11651 16412 21937 433766 16367 18805 16202 228026 56717 72508 21926 19211 16001 16000 16011 11481 56717 18033 16006 16009 16010 16008 29817 16012 104771 IL 1 signaling pathway%WikiPathways_20260211%WP37%Mus musculus IL 1 signaling pathway 16180 19261 67245 16179 108960 26413 266632 53859 18035 26395 12675 26409 19697 16176 16175 22034 16177 16181 73914 16175 26417 12333 266632 68652 18803 18762 66513 18033 12336 18036 16178 19247 26419 12362 18412 230233 16176 54473 11651 17874 IL 3 signaling pathway%WikiPathways_20260211%WP373%Mus musculus IL 3 signaling pathway 16187 20846 110157 20850 14128 20525 56461 12402 15170 11909 20416 23939 16452 19303 22631 22330 20852 14388 21682 54721 17179 26413 14083 18707 14461 18708 17096 12015 12125 14784 12983 20662 11908 22324 12649 12928 16451 20848 18750 15901 14694 26419 14389 20851 18747 12169 16818 54401 26417 13429 11799 26416 16188 19052 11651 18033 58988 56637 21938 12043 20375 18751 14460 17532 16653 17395 19247 12912 109905 19401 20963 20779 18706 12028 17164 12700 18709 26420 15507 16331 12929 14159 15461 19354 107746 20344 606496 56458 18479 216233 20181 26395 15162 17390 12702 19353 12048 12540 14360 Prostaglandin synthesis and regulation%WikiPathways_20260211%WP374%Mus musculus Prostaglandin synthesis and regulation 13617 19225 13618 19223 20194 19109 15446 20200 11745 21391 11752 19222 11747 15483 18783 19224 19215 16952 19214 13070 11746 19216 15484 19219 19220 11749 22287 19217 19218 12306 13614 Myometrial relaxation and contraction pathways%WikiPathways_20260211%WP385%Mus musculus Myometrial relaxation and contraction pathways 51801 16012 64337 50782 18762 224129 20190 53313 11911 19088 18752 210044 18754 16011 14772 14695 14704 18768 14281 14773 18430 228785 14701 19735 14702 50779 16476 104111 14708 18749 12915 54409 11536 12310 11514 432530 216869 11908 18125 56533 18755 20191 64214 54401 16193 26385 12909 381489 12797 22629 12325 24012 17896 50778 18751 14745 56089 108058 18761 18127 109624 14873 12918 18750 22631 19087 14693 66066 18430 16010 20192 67865 104418 19737 11938 16008 58175 14682 14697 22627 18429 19084 19739 55948 11513 107503 234779 16176 14707 11535 19734 16440 18760 11465 14709 140498 14696 19085 56470 11461 53419 14391 18753 20683 14390 11512 14915 16438 12323 12921 19773 238871 23872 11910 104110 18799 19736 51791 20541 14916 109689 14609 22628 12297 12778 16006 18769 18578 14699 18767 22630 12913 11464 16009 18803 14683 17133 12315 11909 14706 11515 11459 14688 17906 50780 16439 18797 12322 18033 12912 60596 Dysregulated miRNA targeting in insulin PI3K AKT signaling%WikiPathways_20260211%WP3855%Mus musculus Dysregulated miRNA targeting in insulin PI3K AKT signaling 12825 14252 12843 12444 56717 53867 20662 12703 14104 107476 12125 26987 19108 12929 12827 26417 18710 53413 12043 12015 18708 12842 19744 12576 19087 110157 Wnt signaling in kidney disease%WikiPathways_20260211%WP3857%Mus musculus Wnt signaling in kidney disease 216799 11848 12387 16348 16973 228357 22408 22409 22410 22421 93735 22420 22418 22414 22411 22417 22416 22419 22412 22413 22415 22422 14362 14370 14366 57265 14369 14371 14367 14368 14365 13543 13544 13542 26420 26414 26419 56637 12005 17311 93687 11789 12234 Triacylglyceride synthesis%WikiPathways_20260211%WP386%Mus musculus Triacylglyceride synthesis 15450 14555 67512 14732 66853 67800 228061 16890 16956 233549 52123 68393 68262 50784 14712 67717 13350 14933 67916 14626 19012 55979 28169 Robo4 and VEGF signaling pathways crosstalk%WikiPathways_20260211%WP3864%Mus musculus Robo4 and VEGF signaling pathways crosstalk 74144 20563 16542 19353 22339 20779 IL 6 signaling pathway%WikiPathways_20260211%WP387%Mus musculus IL 6 signaling pathway 269643 56458 16194 18708 26395 19229 14159 235542 20848 12371 14388 26931 107951 18709 17977 17164 56637 12702 26399 12367 20416 20850 19053 12608 16193 20662 13867 16195 229317 14281 13866 26416 19052 12015 73699 19303 20846 16476 12229 14360 26413 14784 26409 433759 12569 19247 11651 16451 20393 21405 16331 11835 18033 13163 110157 26419 72508 54721 17762 15461 14083 26407 71978 21939 20112 14191 26417 18803 19645 72930 22324 21682 20851 16332 15507 13685 14389 26396 21770 19353 15519 328572 16452 54601 226849 51792 26398 12169 13684 225849 18099 12914 18753 110854 15162 56484 12568 17096 26932 ACE inhibitor pathway%WikiPathways_20260211%WP396%Mus musculus ACE inhibitor pathway 11421 16644 11609 11607 19702 19701 18127 11606 12062 mir 193a and MVP in colon cancer metastasis%WikiPathways_20260211%WP3979%Mus musculus mir 193a and MVP in colon cancer metastasis 27041 53872 78388 17869 12443 12444 miR 127 in mesendoderm differentiation%WikiPathways_20260211%WP3991%Mus musculus miR 127 in mesendoderm differentiation 320202 387146 11477 12627 17126 18119 11480 17128 15376 20997 21331 Mitochondrial long chain fatty acid beta oxidation%WikiPathways_20260211%WP401%Mus musculus Mitochondrial long chain fatty acid beta oxidation 50790 20280 12896 74147 14081 13177 11409 97212 12894 74205 11363 11364 11370 15107 57279 111175 Wnt signaling%WikiPathways_20260211%WP403%Mus musculus Wnt signaling 13544 11848 19353 18792 18751 18755 14296 56637 11789 22416 14365 26420 27373 12443 16835 14370 18760 22421 22411 22408 18750 16476 93897 14369 26931 22419 12387 22413 18754 22414 20379 18752 18472 13543 22420 12445 22418 14362 93735 14368 22417 26932 22415 12005 22410 18761 14367 22422 13542 18759 22409 14283 26414 17869 18762 12444 14371 30050 18753 57265 Kit receptor signaling pathway%WikiPathways_20260211%WP407%Mus musculus Kit receptor signaling pathway 14786 18708 18709 20416 12983 14784 54607 67296 56468 12700 67300 12928 20779 74055 16452 71520 19273 56792 18750 18803 20846 20850 20851 30955 23921 14783 11651 21682 17096 13448 15170 19247 13857 20111 17342 26413 11350 16331 14191 15162 22612 218397 14159 12929 12402 12703 22324 22325 17179 12015 20662 328572 14360 18751 15461 110157 114716 114715 58194 208650 21933 12229 16590 17311 26395 20848 17475 GPCRs other%WikiPathways_20260211%WP41%Mus musculus GPCRs other 319757 12614 18343 81014 14608 18329 259009 15550 12311 56696 18356 171469 80978 170732 113858 18315 113863 69296 11542 13617 107934 113845 18323 18387 22312 57260 213527 18321 18354 81011 18350 11554 14371 218066 78249 18344 81016 18322 113859 18390 257890 113853 66786 113846 18324 18361 18359 13489 233670 80910 259044 14367 53883 14816 18363 113849 258923 113864 58182 11539 76206 113862 27216 14788 259007 18316 258702 18352 18372 21338 18349 12801 258703 18241 17202 11555 81015 80290 64378 20609 64379 18332 26364 18317 113851 13488 12777 58861 18310 113854 18330 15552 14369 258435 18362 14766 23890 113855 13349 81013 22311 20132 18341 18389 18373 18357 13609 259115 14739 57265 13492 113856 110326 24112 54393 81012 113860 258153 18328 12374 22296 258859 208188 404316 113857 81010 18347 18331 18345 81017 22313 18351 258706 22354 113850 18358 113848 14362 113852 113847 258343 29848 170648 258326 258826 113865 244701 94226 22297 23832 71111 18346 12775 18307 Oxidative stress response%WikiPathways_20260211%WP412%Mus musculus Oxidative stress response 394436 26462 14281 13057 17161 20683 26416 26414 13076 14872 18032 12359 14782 20657 14778 14629 17748 18104 50493 20656 15368 16477 14391 14775 18033 56615 20655 56551 G1 to S cell cycle control%WikiPathways_20260211%WP413%Mus musculus G1 to S cell cycle control 12567 12571 12443 12444 12445 12575 12576 12572 66671 13555 242705 13557 19650 19645 104394 13559 50496 21781 211586 12566 12447 12448 18974 18973 12530 22390 268930 12534 12544 19891 68240 68275 17216 17215 17217 17218 17219 17220 18392 18393 50793 26428 26429 56452 19075 19076 18969 18538 22059 13197 17246 12580 12579 12581 12578 12427 11920 12577 12452 17869 17420 Distal convoluted tubule 1 DCT1 cell%WikiPathways_20260211%WP4183%Mus musculus Distal convoluted tubule 1 DCT1 cell 16517 69847 12283 53416 232341 56365 20497 Ethanol metabolism resulting in production of ROS by CYP2E1%WikiPathways_20260211%WP4265%Mus musculus Ethanol metabolism resulting in production of ROS by CYP2E1 26419 13106 20683 26396 17133 17134 26395 17135 18024 18753 Nuclear receptors in lipid metabolism and toxicity%WikiPathways_20260211%WP431%Mus musculus Nuclear receptors in lipid metabolism and toxicity 11303 19013 12780 19016 18171 27413 19401 13124 13077 27409 11307 13082 12355 22337 76408 13088 13122 218772 13115 19411 13120 18670 13081 22259 18671 20186 13106 26874 19015 69050 19299 Eicosanoid lipid synthesis map%WikiPathways_20260211%WP4335%Mus musculus Eicosanoid lipid synthesis map 18784 53357 18783 211429 74451 19225 64292 19215 11689 TCA cycle%WikiPathways_20260211%WP434%Mus musculus TCA cycle 18563 18597 68263 27273 170718 27402 235339 13382 66945 17449 20917 11429 381511 56451 78920 18604 15929 66052 228026 66925 67680 12974 20916 67834 236900 269951 18293 18598 382051 14194 17448 Sphingolipid metabolism overview%WikiPathways_20260211%WP4344%Mus musculus Sphingolipid metabolism overview 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 67260 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 Glycerolipids and glycerophospholipids%WikiPathways_20260211%WP4345%Mus musculus Glycerolipids and glycerophospholipids 14732 19012 66586 212862 68671 74596 320951 13350 27388 66853 18805 104418 19210 18618 68262 52858 12651 13026 75320 102247 67800 18778 116939 Cholesterol metabolism with Bloch and Kandutsch Russell pathways%WikiPathways_20260211%WP4346%Mus musculus Cholesterol metabolism with Bloch and Kandutsch Russell pathways 20787 110446 11303 12642 15357 13122 22259 20652 14104 13360 235293 13595 73166 13116 104086 223920 110460 208715 15360 17855 68603 192156 20775 319554 320581 14137 14593 110196 16987 74754 22260 11307 218203 20788 14081 74205 50790 26897 171210 18194 74754 54326 12686 83603 68801 76267 56473 20249 20250 13121 73166 66234 98386 15490 18194 Eicosanoid metabolism via cyclooxygenases COX %WikiPathways_20260211%WP4347%Mus musculus Eicosanoid metabolism via cyclooxygenases COX 19223 21391 15446 18784 19015 69050 53357 18783 211429 19224 19225 64292 19215 11677 67103 77219 13117 277753 13118 64385 72054 11430 93732 80911 113868 74147 19222 66469 19220 19214 14764 21390 19224 Eicosanoid metabolism via lipoxygenases LOX %WikiPathways_20260211%WP4348%Mus musculus Eicosanoid metabolism via lipoxygenases LOX 13117 16993 211666 625249 72054 14775 11689 66447 11687 15446 13850 17001 277753 13118 64385 72054 11430 93732 80911 74147 113868 14598 23887 13479 319446 11684 67103 77219 Eicosanoid metabolism via cytochrome P450 monooxygenases%WikiPathways_20260211%WP4349%Mus musculus Eicosanoid metabolism via cytochrome P450 monooxygenases 13850 13117 277753 13118 64385 72054 13095 13096 13097 13098 13099 226143 404195 72082 13109 19013 One carbon metabolism%WikiPathways_20260211%WP435%Mus musculus One carbon metabolism 108156 69606 13433 14450 13436 13361 11720 12116 108645 108147 14317 21452 17768 434437 108037 238505 53320 77683 269378 20425 270685 13435 17769 210009 110147 107747 74340 22171 107885 Omega 3 omega 6 fatty acid synthesis%WikiPathways_20260211%WP4350%Mus musculus Omega 3 omega 6 fatty acid synthesis 56473 14081 74205 50790 54326 68801 76267 11430 80911 26897 171210 74205 50790 18784 53357 18783 211429 Omega 9 fatty acid synthesis%WikiPathways_20260211%WP4351%Mus musculus Omega 9 fatty acid synthesis 76267 14081 14104 74205 50790 54326 68801 170439 12686 54325 20250 56473 26897 171210 PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine%WikiPathways_20260211%WP4398%Mus musculus PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine 18595 16765 Matrix metalloproteinases%WikiPathways_20260211%WP441%Mus musculus Matrix metalloproteinases 26561 234911 17390 17385 17388 240047 17395 17392 118453 21858 17393 17384 23948 58223 12215 17381 17389 21411 17387 214766 30800 21857 17394 17386 21859 17391 21926 83995 110595 Oxidative stress and redox pathway%WikiPathways_20260211%WP4466%Mus musculus Oxidative stress and redox pathway 14780 18477 22166 50868 332309 12505 14854 75475 20511 26570 20371 14873 14870 14775 20514 433899 625249 14776 14381 14664 14629 18024 11689 18181 14871 14857 14782 12411 15926 56615 14863 14660 14630 110175 14778 75512 67305 69590 269951 14380 110208 14872 103140 14862 14864 14865 14866 14867 68312 14858 14859 14860 14869 68214 211666 66447 54486 76263 23887 71522 207182 14598 12780 27416 66988 16790 104245 28248 24059 12477 13058 13057 19353 17972 17969 17970 21672 11757 53381 54683 11758 320769 19224 19225 20201 20202 20655 20656 20657 50493 26462 232223 Adipogenesis genes%WikiPathways_20260211%WP447%Mus musculus Adipogenesis genes 20378 27217 22410 20185 13591 13865 14362 16334 16370 22408 116939 20787 16369 15251 20183 20181 12606 18196 20683 12153 12608 12387 17873 21405 230709 13819 228775 17977 268903 20602 11606 16846 14705 20528 16905 12156 19883 13555 12159 14463 14560 16878 13198 16890 12912 19223 16880 13197 13542 14102 52637 93691 11622 17319 57264 67512 20851 12804 18534 13046 20847 66277 14234 19651 18787 12224 17260 19645 20848 17984 110075 14461 17127 11537 232174 20852 16193 20745 14599 21803 11450 15903 22419 13654 59027 14462 56758 11604 11520 22160 20846 19650 19016 97064 22259 12609 104394 14815 21926 23849 19013 20379 16956 64898 17978 14245 13386 18413 16195 19017 16333 12702 20249 13082 17258 384783 103968 19401 105980076 17259 19015 69050 11770 12703 22227 16000 56458 20850 64899 15361 17261 19116 74551 16367 21887 Circulating monocytes and cardiac macrophages in diastolic dysfunction%WikiPathways_20260211%WP4474%Mus musculus Circulating monocytes and cardiac macrophages in diastolic dysfunction 20296 16153 20750 12772 Complement and coagulation cascades%WikiPathways_20260211%WP449%Mus musculus Complement and coagulation cascades 19123 12259 16644 14058 17174 12258 21788 22371 18792 232345 12946 12269 14069 58992 12509 21824 18815 50908 12266 12628 109828 11905 13136 12267 14962 14061 18787 14066 13137 109821 14068 14067 69379 18793 18816 18791 12263 56373 17194 15139 12274 17175 50909 12260 14071 14062 12268 12630 12273 12061 11537 15160 19128 17221 12902 12262 268591 14060 16621 110135 12279 Elongation of very long chain fatty acids%WikiPathways_20260211%WP4491%Mus musculus Elongation of very long chain fatty acids 14104 68801 12686 54325 74559 170439 83603 54326 56473 170439 68801 76267 12686 30049 20249 20250 329065 56473 54325 74559 76267 IL 2 signaling pathway%WikiPathways_20260211%WP450%Mus musculus IL 2 signaling pathway 16183 20851 16453 12928 22324 20846 12912 23872 17096 11651 21752 12700 23871 19247 14694 12703 20850 230126 18707 13684 12402 20844 16818 16185 16184 110157 12508 15894 56717 27979 16451 14784 26395 20963 12043 17346 18708 12702 15962 74769 16432 26419 14389 20848 12675 19229 16452 22608 18709 14815 18795 19697 18706 16186 56324 18033 18762 26396 64685 14360 16653 26420 17164 26413 72508 30955 12929 20662 26416 15519 26417 16367 56484 15170 20416 384783 Osteoclast signaling%WikiPathways_20260211%WP454%Mus musculus Osteoclast signaling 18383 18591 194352 21943 11433 15977 20544 66290 21934 15975 16416 13038 238377 20750 GPCRs class B secretin like%WikiPathways_20260211%WP456%Mus musculus GPCRs class B secretin like 12311 54598 12921 12922 381853 93896 14652 14527 14602 213527 19228 11517 319229 22354 22355 26364 13733 330814 99633 319387 170757 237175 Inflammatory response pathway%WikiPathways_20260211%WP458%Mus musculus Inflammatory response pathway 12524 21938 16779 15978 21827 22370 16183 16190 16185 16818 16777 16186 16189 12825 21939 12842 16782 12843 12487 21947 21937 14268 12519 16184 226519 22637 16776 21825 16191 16192 Blood clotting cascade%WikiPathways_20260211%WP460%Mus musculus Blood clotting cascade 14058 14061 58992 99571 18815 14071 14070 18792 110135 22371 14067 14060 109821 18816 18791 18788 18787 14069 14068 14161 Lipids measured in liver metastasis from breast cancer%WikiPathways_20260211%WP4627%Mus musculus Lipids measured in liver metastasis from breast cancer 79235 Sphingolipid metabolism integrated pathway %WikiPathways_20260211%WP4690%Mus musculus Sphingolipid metabolism integrated pathway 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 71949 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 76893 67260 Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle%WikiPathways_20260211%WP4763%Mus musculus Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle 19017 56637 21425 19017 21425 T cell receptor signaling pathway%WikiPathways_20260211%WP480%Mus musculus T cell receptor signaling pathway 72699 218397 12481 22325 26411 12501 22376 16453 12503 78473 108723 20662 94176 56233 14389 12387 12929 19395 14360 27387 20851 18003 16428 13800 14281 20218 18709 22323 72349 71520 12525 20663 18019 12507 23853 54353 12928 17096 11431 13430 26431 18761 19303 15170 14784 16797 16818 20963 26417 545902 12700 18708 11308 16476 101540 13383 77647 18479 53416 19271 12488 12504 19247 20850 12500 242687 11857 17975 23939 23880 26396 22165 24055 192656 54126 104248 73341 20779 16438 14083 22248 22145 17829 11350 26558 12608 14357 18803 20416 26413 19248 20846 230126 57257 329693 16923 16822 26395 109905 208650 77799 240754 17973 26401 22324 12402 12914 22154 545622 109880 19200 20491 74039 19264 22637 13169 19229 12502 14026 215280 19260 19354 27371 12912 54390 12540 19056 94212 11651 17444 12042 107746 GDNF RET signaling axis%WikiPathways_20260211%WP4820%Mus musculus GDNF RET signaling axis 24063 17300 20671 14048 20666 18504 58198 11609 14234 14573 14462 329628 268902 12159 16869 20563 23892 19713 14585 14634 67042 72938 12387 Peroxiredoxin 2 induced ovarian failure%WikiPathways_20260211%WP4835%Mus musculus Peroxiredoxin 2 induced ovarian failure 12028 13063 13070 15494 12367 20845 21672 Alpha 6 beta 4 integrin signaling pathway%WikiPathways_20260211%WP488%Mus musculus Alpha 6 beta 4 integrin signaling pathway 11848 20166 192897 14360 23844 14083 16403 16785 22352 229933 14784 13518 59079 13866 18708 18709 18710 18706 74769 30955 18707 12821 20416 19882 55948 16772 16777 226519 16776 16779 16773 16774 16780 16782 18479 19353 18810 12476 384783 16367 13649 11835 22062 11350 54401 22627 22629 22631 22612 109620 17295 13685 13684 16418 18208 11651 12367 12015 18750 56717 18753 17393 20779 17126 17127 12575 Mapk signaling pathway%WikiPathways_20260211%WP493%Mus musculus Mapk signaling pathway 21813 19252 17165 13712 170706 26940 19418 12929 216869 110651 26403 16765 218397 12369 320139 381921 22059 16177 12368 13649 11652 21926 13198 12928 69253 15370 14175 12475 11911 14103 65964 13197 21812 19055 12367 68652 18752 26409 56274 12370 109689 19419 14784 269275 16151 109880 26420 20807 26415 53859 26565 26401 19279 18596 26396 21809 19259 16653 19042 16175 12531 14281 18755 78405 12371 17451 16150 15507 11479 11651 53608 19059 50932 12540 110157 50772 23939 26408 18753 18176 18751 26414 11909 26404 13645 18099 16476 26407 225028 26413 71751 21808 193740 18784 216965 26395 63953 18049 19043 17164 14828 67603 30957 319520 224105 26398 225724 240672 19060 109905 19058 26921 17869 66513 15481 21803 13163 18033 26417 233046 17762 26399 18762 103988 18015 23797 19056 19354 12362 12064 18479 26419 16178 18747 26416 22030 26400 19057 215449 29857 22034 18211 26410 17532 16176 20663 235584 114713 14673 12366 19353 17260 26411 18591 23938 14102 192176 17187 16478 Deregulation of renin angiotensin system by SARS CoV infection%WikiPathways_20260211%WP4965%Mus musculus Deregulation of renin angiotensin system by SARS CoV infection 11607 70008 11421 11609 Hypoxia dependent self renewal of myoblasts%WikiPathways_20260211%WP5023%Mus musculus Hypoxia dependent self renewal of myoblasts 15213 15205 15214 17877 17879 17927 12575 18509 17928 18128 56458 15251 22027 Hypoxia dependent proliferation of myoblasts%WikiPathways_20260211%WP5024%Mus musculus Hypoxia dependent proliferation of myoblasts 22339 17700 433766 17927 22084 15234 67731 17877 64930 11651 17127 16000 74747 19744 14164 56717 17126 17928 12310 Hypoxia dependent differentiation of myoblasts%WikiPathways_20260211%WP5025%Mus musculus Hypoxia dependent differentiation of myoblasts 12575 26416 17877 17878 18128 112405 12576 319594 15251 17879 17928 20893 22339 17928 Na K ATPase Src signaling%WikiPathways_20260211%WP5051%Mus musculus Na K ATPase Src signaling 230661 19354 56637 11928 11798 22165 14360 20662 109905 12391 16542 12015 170758 20363 14784 12043 110157 17295 13649 26420 320207 18479 20811 16202 18481 11796 107746 50772 11797 12387 243659 330662 20418 11836 12928 26396 26397 30955 12371 15461 56717 13067 109880 26413 12444 13063 14083 22324 23797 241656 51789 18595 12445 11931 23938 215449 12143 14254 26419 19353 20459 20779 224105 83813 26399 214230 225724 12929 12390 12389 20416 70584 11783 23939 11651 74769 18707 13866 18596 109880 26395 12443 16001 18706 15162 19211 13712 75669 12367 12927 11652 18708 18709 16476 29857 14191 Burn wound healing%WikiPathways_20260211%WP5056%Mus musculus Burn wound healing 22339 18127 16772 12842 21926 15200 21803 18613 73122 18126 14248 11459 14609 56189 216799 Nuclear Receptors%WikiPathways_20260211%WP509%Mus musculus Nuclear Receptors 20182 26379 218772 14815 26424 22026 19411 18227 11835 18667 21907 11819 22337 26423 21834 353187 21833 19885 20183 19883 19015 69050 13865 19016 26563 11614 15370 20181 13983 22260 22259 19401 13982 18171 13864 19013 15378 26380 12355 ID signaling pathway%WikiPathways_20260211%WP512%Mus musculus ID signaling pathway 15901 15902 15903 15904 19645 19651 19650 21423 17927 12566 12428 12447 13712 13714 13713 19185 15205 18507 18504 18510 17877 17878 17928 21406 20787 17681 12156 12168 22339 14254 16542 17125 17128 17129 11910 17127 21815 11482 16818 16001 16000 16367 12387 21752 18033 19697 12161 21947 18049 13645 21416 Fibrin complement receptor 3 signaling pathway%WikiPathways_20260211%WP5128%Mus musculus Fibrin complement receptor 3 signaling pathway 11651 16193 16150 18706 18815 18033 20963 19696 142980 208650 17874 15977 11848 16179 18791 15945 54354 117149 22034 106759 12475 22177 14127 330122 18815 266632 17087 16803 21898 20779 225471 54131 16409 16414 21926 20296 12675 16151 14161 108960 16160 18126 110135 99571 19697 Oxylipins pathways%WikiPathways_20260211%WP5140%Mus musculus Oxylipins pathways 15446 13850 66469 19215 64292 19223 21391 11689 11688 11684 11687 76267 56473 19225 17001 16993 14598 13479 14775 12408 54486 13850 Proteasome degradation%WikiPathways_20260211%WP519%Mus musculus Proteasome degradation 19171 22190 319170 93841 19166 15007 19186 19170 26442 15007 66997 67151 19184 22210 16913 17463 19172 66105 69077 22201 103963 19182 51788 26445 16912 15978 19167 22223 15007 53380 15007 22123 23997 56550 20014 15270 66413 26444 26440 74153 19175 26443 19173 19192 19179 66998 216080 17999 67089 23996 19185 22187 15007 26441 19188 19177 19181 15007 26446 21762 57296 19184 Biogenic amine synthesis%WikiPathways_20260211%WP522%Mus musculus Biogenic amine synthesis 14417 13195 21990 15186 13166 21823 18948 11423 12846 18478 12647 11298 14415 17161 107626 Regulation of actin cytoskeleton%WikiPathways_20260211%WP523%Mus musculus Regulation of actin cytoskeleton 56419 108083 26413 12671 18719 227753 231637 18479 18643 225326 14176 18590 14163 320207 20663 108100 29875 22330 14165 16801 54126 14674 19684 77579 329165 243764 12669 240752 14180 13649 13800 237860 232906 170758 242687 241656 227733 17532 26395 16885 12061 14178 22349 14673 50884 14169 11461 18709 224105 14186 14174 213788 14167 12540 19241 18705 13645 226970 12927 107589 245857 14175 18708 18481 330662 12672 12632 12475 18596 67771 18706 14083 80857 14171 11848 20544 14184 18704 64654 74769 12062 19878 14170 14172 18718 56636 18176 14173 18710 22350 19877 11465 67112 14268 80903 30955 73341 17901 19353 109880 17931 22376 66922 75669 20130 11789 66985 18595 16653 14168 18720 83767 70584 109711 14701 13367 18717 20662 17698 12928 16334 109700 110157 12988 117150 26417 18591 76884 17897 26396 19303 19354 16333 14183 18707 50772 214230 23805 216963 12631 17451 14177 14164 14061 14062 14182 14166 14179 22324 225724 101314 Lac Phe pathway%WikiPathways_20260211%WP5240%Mus musculus Lac Phe pathway 27416 66054 Comprehensive IL 17A signaling%WikiPathways_20260211%WP5242%Mus musculus Comprehensive IL 17A signaling 20302 20311 14268 20304 12540 11459 14825 20315 20303 11475 16000 24099 14118 15511 20613 17345 17220 11522 15289 12842 18591 15132 20656 269437 20311 22059 18749 11749 18792 16176 19225 17392 20846 14219 19353 56717 107589 14701 320011 16193 17218 12367 18590 19325 66870 266692 12266 76709 67089 18793 19697 18938 104184 20583 20309 11848 18481 16176 109828 17387 56378 14432 66922 67771 11927 12282 269823 11600 17395 20310 100503605 15129 13649 19704 230709 18393 19646 12540 19353 18793 56045 12301 22589 18392 18792 18148 50927 18538 19290 98415 18412 67443 12043 17130 17126 56208 20848 66734 17131 225326 17217 17219 17216 21803 17215 56717 20315 17126 17127 11651 20613 20583 21872 16452 Dravet syndrome Scn1a A1783V point mutation model%WikiPathways_20260211%WP5298%Mus musculus Dravet syndrome Scn1a A1783V point mutation model 20265 20501 19049 13823 20511 12298 12297 16832 20512 14580 16828 55936 17161 12295 16542 12286 19417 14810 12287 109731 12294 21926 20912 14802 14660 72821 18706 279653 56716 54393 14415 18033 14400 14396 242425 14811 53623 14402 235281 55943 14645 20910 20266 56717 399548 109270 20269 14799 78757 16490 12322 20265 72446 244059 227743 19094 14168 11651 14417 108069 228960 14394 57138 16524 16519 16513 20525 20503 76257 20527 232333 14395 14397 72961 Globo series sphingolipid metabolism%WikiPathways_20260211%WP5305%Mus musculus Globo series sphingolipid metabolism 14344 227671 93961 26879 Wnt signaling pathway%WikiPathways_20260211%WP539%Mus musculus Wnt signaling pathway 22218 22413 99470 14200 21374 93840 11789 57265 13728 77578 22415 12387 93687 13543 13542 14368 26419 23859 12005 14371 23988 12322 109689 26413 22418 14362 58198 22408 212398 13385 11651 16842 93960 27373 26417 19099 208846 104318 17127 13017 26420 11848 18099 26564 20319 20664 19353 20377 12443 14367 216869 12534 13132 22417 140577 56637 13380 17863 12995 26992 16973 14366 319478 20682 12532 12393 12234 18504 21413 16971 12550 26409 56505 108058 59004 16974 26965 75826 13000 14369 22416 16480 17128 22421 14370 15258 12323 12961 18751 13383 26423 16476 21418 67087 18750 13001 328572 13016 14296 21402 110157 12325 12006 76281 21423 13544 17755 19052 Synthesis and degradation of ketone bodies%WikiPathways_20260211%WP543%Mus musculus Synthesis and degradation of ketone bodies 15356 110446 15360 67041 71911 Exercise induced circadian regulation%WikiPathways_20260211%WP544%Mus musculus Exercise induced circadian regulation 22229 30960 11865 20610 18627 12608 22763 18701 14864 75062 319187 12952 22057 54375 19290 52331 64209 19053 12741 353187 14373 13690 12953 12753 17878 50884 15502 217166 12417 27057 53412 14011 216558 18626 238988 22153 23994 14869 19317 15481 68652 26441 14585 14998 16601 12226 19663 22218 319554 Steroid biosynthesis%WikiPathways_20260211%WP55%Mus musculus Steroid biosynthesis 15497 13074 15493 15496 15492 15495 15494 15486 15487 15485 14060 15488 15490 Calcium regulation in cardiac cells%WikiPathways_20260211%WP553%Mus musculus Calcium regulation in cardiac cells 12295 12325 20191 50779 104110 14702 432530 12322 18751 12290 64337 50778 67972 14678 53313 320707 14613 18797 11549 14696 18821 58175 18749 20190 12326 224129 18768 216869 67865 11550 11554 51791 12292 12672 243764 12288 14615 16500 210044 14609 16439 19085 12289 108058 14695 12286 16519 19737 54401 14697 16521 22631 22629 14611 16438 11941 14620 14621 55948 18760 14701 14682 66066 18753 14708 14623 14679 18754 64214 24012 14773 14709 18767 20192 16440 11514 12669 56470 11548 12315 14225 14618 14616 56533 12372 104111 22627 11749 14672 14707 11515 19734 20541 22630 11513 14687 11556 14622 12317 50782 14699 18762 19084 14693 18769 19736 18755 19088 18761 14704 18750 118454 14688 12373 14681 110893 18821 11938 19735 109689 14683 14619 12287 14677 12671 19739 213788 12323 14612 14706 22628 52163 12297 18752 11512 14772 19087 11555 50780 14617 26385 27222 11931 11936 11932 11933 Eukaryotic transcription initiation%WikiPathways_20260211%WP567%Mus musculus Eukaryotic transcription initiation 235459 24074 13872 68705 229906 23894 67710 102216272 108143 20022 68153 74197 245841 67065 20019 209357 99730 26939 20016 21343 66464 16202 20018 17749 20020 69920 14884 78929 66671 12572 20017 226182 67005 66420 21374 70428 231329 14885 17420 20021 13871 Signal transduction of S1P receptor%WikiPathways_20260211%WP57%Mus musculus Signal transduction of S1P receptor 26417 18705 13610 26413 26934 13609 20698 14677 23939 18797 11652 54447 20598 14678 94226 29857 23797 11651 50772 56632 14679 14739 Monoamine GPCRs%WikiPathways_20260211%WP570%Mus musculus Monoamine GPCRs 15465 11553 15562 13490 15466 12671 11549 13492 15564 13491 11556 11548 243764 15565 15552 12669 15566 12672 13489 213788 11551 15558 15557 13488 15563 11554 11552 15560 15559 15550 11550 15551 11555 FAS pathway and stress induction of HSP regulation%WikiPathways_20260211%WP571%Mus musculus FAS pathway and stress induction of HSP regulation 20740 16175 14084 12369 15507 192656 13368 18479 11783 13163 17164 12370 11545 13347 11857 14103 14082 19645 26419 16476 102626 26398 12368 224105 26409 16906 16907 12371 12633 12043 26401 12367 21926 19090 16905 19249 14102 EGFR1 signaling pathway%WikiPathways_20260211%WP572%Mus musculus EGFR1 signaling pathway 13645 110157 15461 18176 16653 56392 18708 26405 50915 14784 14783 26406 20662 14786 18709 20416 18710 18706 74769 18707 30955 14388 14389 16451 20846 16452 20848 20850 20847 20851 26395 18750 26401 18762 18760 18759 18751 26396 26397 23938 26407 22324 57257 22325 23939 26413 26417 13714 13712 26419 26400 19279 14609 54401 232341 13649 110310 16691 16667 16668 382523 107686 18810 19248 20779 12402 12928 12929 67184 19353 19229 12389 12390 17973 17974 18803 216963 19734 12703 12702 16332 271457 98910 11843 22687 19766 53859 19730 218397 20459 19084 15170 19247 22038 74155 13449 18738 80794 208650 18806 18805 13858 13860 15194 240752 56726 12988 194590 19765 64143 19707 51789 11308 20663 13429 20408 12540 24064 16478 14281 12606 17869 12608 23980 194655 20466 21815 433759 58194 20404 16476 20683 11651 19259 20617 20111 110651 20112 11771 73178 26365 13627 72993 216190 23942 13859 13854 215114 19727 26416 57783 245688 13196 20910 12388 109333 18479 27387 12927 12371 73086 17126 17127 11908 12912 56458 19303 13710 107435 12322 16396 11836 109904 234779 19252 Leptin insulin signaling overlap%WikiPathways_20260211%WP578%Mus musculus Leptin insulin signaling overlap 16452 18607 16847 12702 20848 18710 11651 216233 30955 16337 12703 16333 104418 16846 16367 384783 16369 16370 Integrin mediated cell adhesion%WikiPathways_20260211%WP6%Mus musculus Integrin mediated cell adhesion 16401 73647 109711 16202 14083 16416 16407 20662 22793 109905 16409 12928 16404 16421 12337 381924 20363 19877 16410 16400 22330 107746 16399 12338 19354 19303 214230 26395 12927 192897 320910 18607 12335 20779 330662 57257 109880 12390 16408 11836 268958 23830 16411 109700 14360 26414 12988 12391 212541 15461 23939 12389 16420 50772 20416 16412 12334 23797 26396 18709 104099 21961 12339 16402 213119 110157 22325 12540 23938 12336 16414 224105 26397 26413 20411 215449 26399 18481 16398 11652 12333 19353 19878 26431 22323 16403 18479 11651 14784 16419 241226 319480 54126 228785 70584 225724 29857 170758 21894 20418 miR 1 in cardiac development%WikiPathways_20260211%WP608%Mus musculus miR 1 in cardiac development 16508 54352 15111 Pentose phosphate pathway%WikiPathways_20260211%WP63%Mus musculus Pentose phosphate pathway 14381 66171 66646 21351 19895 21881 110208 Insulin signaling%WikiPathways_20260211%WP65%Mus musculus Insulin signaling 18710 210789 16369 16568 14252 20111 20913 20910 26414 19354 19246 110651 26408 11652 72508 26406 56458 20911 12402 13712 15461 13684 12702 13660 26419 19268 26412 104215 14281 22433 26396 19211 50932 20418 20912 16370 11845 26405 23921 26420 22084 110157 26397 18709 14251 73086 18642 18753 18704 16890 13685 53859 19159 20662 18751 225724 50915 26415 23938 16573 16476 14936 17913 107746 19353 19094 18707 50772 56637 14784 14388 18755 26417 170755 108079 18708 80794 58988 232493 75669 20909 27219 26921 56717 20614 399510 16332 23939 18761 208650 12703 14783 26407 11840 26409 26399 233071 22318 16367 26413 20416 12928 269180 26401 19341 16150 269881 225326 30955 259300 64930 20112 216148 18607 18706 11651 26400 80837 12331 29857 53608 18705 26395 67071 18759 19247 56437 71751 18762 74769 225028 338372 19744 19047 434233 26404 20807 56484 20619 20663 56613 18750 26398 18641 27357 20411 105787 26410 20393 228775 26403 26416 26411 13653 18605 16001 16337 20525 20528 Amino acid metabolism%WikiPathways_20260211%WP662%Mus musculus Amino acid metabolism 14782 15186 12411 20603 17449 14860 18746 11898 11754 107508 13382 18534 14661 15360 140483 13195 11364 14719 11992 27273 19125 78920 14085 74147 15109 105148 11668 320092 227095 234724 69719 212679 12116 12035 113868 58875 108682 18452 18597 22018 14630 11532 18242 242083 26876 17161 21823 231691 102436 14378 22375 16828 11522 14660 66945 23874 27053 18597 110695 246221 56451 15356 11529 18563 209027 18293 109900 14854 14194 107869 21990 17850 11846 17448 15926 18948 13166 11429 14645 104458 72039 18263 14317 56454 14718 12974 104112 22321 27402 56720 18416 66925 68738 227231 20810 15107 11847 Leptin and adiponectin%WikiPathways_20260211%WP683%Mus musculus Leptin and adiponectin 72674 105787 19079 16846 68465 107476 19082 16847 12894 11450 Wnt signaling pathway and pluripotency%WikiPathways_20260211%WP723%Mus musculus Wnt signaling pathway and pluripotency 22059 71978 18761 13543 73699 14362 22418 16974 269643 18751 22411 14369 13017 19053 19052 12914 13542 14366 21415 93735 14283 52432 14370 21413 26409 56637 14296 13016 22410 71887 17869 16835 22419 12387 22408 22411 22422 22416 12444 13544 17393 26420 22421 18044 18750 22414 16842 26931 72293 21410 14365 20674 18792 18755 18760 22413 30050 18472 19015 69050 18099 51792 21405 18752 18762 14368 57265 72930 12006 12445 14367 22417 71950 11789 26932 16476 328572 22412 16973 12388 22420 26414 18753 110854 18999 12443 12005 26934 22409 27373 22415 56805 93960 18754 14371 18759 15221 11848 12505 Glutathione and one carbon metabolism%WikiPathways_20260211%WP730%Mus musculus Glutathione and one carbon metabolism 16790 14381 23887 14775 12116 13433 210009 17769 14630 14782 14598 14854 14629 434437 74340 238505 108645 13435 218865 14598 14776 13436 11720 75475 15926 269378 20425 14778 108037 625249 12411 107869 Tryptophan metabolism%WikiPathways_20260211%WP79%Mus musculus Tryptophan metabolism 64385 70790 15930 13106 57751 270076 56752 15469 11669 19378 107626 13076 17246 18293 109731 11671 13195 15108 12359 22215 15107 13123 23923 110446 70789 71562 13078 11298 11761 74754 266645 13077 72082 22375 21743 13075 11668 320092 13110 107766 76507 93747 56720 13107 21990 Focal adhesion%WikiPathways_20260211%WP85%Mus musculus Focal adhesion 12826 230661 11465 18607 19354 56637 107589 53867 21828 22165 14360 20662 12831 16420 105083 109905 12391 12015 319480 170758 12815 16780 20363 14784 329278 12043 110157 227377 12333 15234 17295 13649 11848 16404 16409 12843 26420 320207 15891 18479 12832 20811 16202 94216 228785 18481 21827 16398 11796 16773 107746 18717 12824 12829 50772 13645 192897 16402 11797 16775 320910 381924 16416 19878 16776 243659 330662 12643 20418 213119 11836 12928 26396 26397 81877 170736 30955 16400 12842 16403 14205 109880 192176 26413 12444 71785 13367 17931 16410 14083 22330 16772 22371 12825 22324 23797 16411 241656 51789 16414 18595 12445 54635 23938 16399 215449 12143 14254 26419 19353 23928 19877 20459 21826 12540 16421 22793 20779 224105 18591 83813 20750 26399 214230 225724 12929 14268 11855 12814 16401 12390 12389 22370 16000 20416 109711 18654 70584 11852 18590 23939 11651 19303 74769 18707 13866 18596 109880 26395 226519 12443 16779 22340 21894 18706 16774 15162 19211 22341 16777 13712 19699 75669 12827 11461 16412 241226 16407 104099 22339 12834 16419 21825 16408 12927 11652 18708 18709 16782 22323 21923 17904 16476 29857 14191 21960 Toll like receptor signaling%WikiPathways_20260211%WP88%Mus musculus Toll like receptor signaling 24088 21898 117149 142980 17153 73914 266632 225471 17874 16179 19765 106759 108960 14082 22031 12367 12370 56489 11308 54131 56480 22026 26416 12675 68652 19106 22034 26399 16150 17121 16151 18033 18034 IL 4 signaling pathway%WikiPathways_20260211%WP93%Mus musculus IL 4 signaling pathway 18762 11651 18033 56468 16190 20852 18708 19094 72508 15170 16451 13712 26413 13449 19247 16453 17969 16818 20662 20850 15361 384783 20416 14083 14159 14360 16189 54721 16367 18707 218397 26417 26416 16164 20844 18753 12767 12914 20846 18759 12702 12015 16452 114774 20375 320129 328572 23871 75292 20779 18803 16331 11909 14784 12703 16186 18706 18709 19697 12402 12048}