S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation 104923 70266 67870 67873 56369 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III 52637 246221 14718 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) 14417 14415 14645 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II 13075 13087 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 56473 54326 68801 74147 56348 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI 52815 GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation 110446 110460 93747 270076 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis 27053 PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation 111175 11671 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II 71707 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism 114663 228550 55980 320404 69718 19062 212111 320634 104015 16330 16331 16329 16332 233011 20975 17330 242291 101490 19211 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) 107869 12411 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 22247 69719 75533 56749 51797 110074 21915 55936 382985 18102 18103 79059 56520 54369 22169 66566 20135 66588 20133 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis 268566 SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis 216343 13195 21990 11298 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis 18194 15490 73166 98386 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis 56473 20216 233801 26458 272428 94180 328845 14081 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II 74157 234728 24018 67897 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis 23887 11687 17001 11684 14865 11689 625249 13479 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 68603 14593 110196 110446 319554 110460 15360 192156 100040592 17855 15357 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation 216456 14660 L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation 15233 234724 15445 14085 14874 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation 18948 12846 791260 26876 11669 17161 109731 11671 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II 245847 67980 26384 56174 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation 71761 108156 15109 243537 14317 NADH REPAIR%BIOCYC%PWY-6938 NADH repair 100043349 246703 URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) 64705 99586 103149 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds 18796 107650 18797 18798 103199 18799 72469 18795 18706 74769 18707 18711 18802 217837 74055 219024 114875 18717 27399 74302 84095 269437 104709 18803 228550 83493 234779 320404 76500 69718 72519 19062 75669 212111 327655 320634 75678 104015 320207 16330 18718 16331 52858 108083 16332 18704 233011 240752 20975 18705 17330 225326 18720 18719 19211 97287 67073 227399 18710 117150 271424 30955 18708 18709 224020 227733 269615 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation 212647 19125 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I 14651 109801 L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation 76282 108682 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA 68738 60525 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I 212503 228608 20229 69215 11754 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis 18478 ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing 11686 26569 320997 23801 545975 21816 433091 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis 107239 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis 22247 69719 56749 GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation 76952 22436 18950 14544 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation 20656 667310 12359 20657 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis 71780 114663 55980 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) 78330 68202 17716 17717 407790 17718 17719 17720 67003 22273 66694 100042918 67530 67273 70316 68198 66495 67130 75406 66416 68375 66108 104130 12858 66945 68342 12857 66377 17711 68197 227197 67184 100042503 17708 66046 17709 230075 17710 66916 67264 66218 54405 17991 66091 110323 66052 67680 66925 225887 100040287 12861 72900 239760 22272 66414 226646 624814 17995 17993 595136 623286 66445 17721 17722 12868 66142 12866 100041785 66152 17992 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis 227697 236082 57357 67422 52014 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 14450 68870 56248 108147 11565 100042069 23917 14923 11564 11566 231327 18103 237823 79059 78801 56520 67054 54369 11636 11637 229949 20135 635960 229363 20133 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) 69564 74080 226518 66454 225994 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt 14417 14415 14661 268860 214579 14645 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 66171 110208 14381 UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) 71365 71707 12850 56075 71883 217707 227683 52064 230027 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 100042069 23917 14923 18103 79059 56520 54369 20135 229363 20133 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis 108037 236539 100678 56433 20425 107272 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage 171567 14923 75533 18103 79059 13178 56520 27369 54369 18102 229949 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) 394434 13371 20887 13370 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation 216456 14660 27053 VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle 27973 69568 56316 18104 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I 107141 81906 13087 13078 13077 71519 74134 18984 20887 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation 11486 18950 GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I 23887 14862 14866 68312 76263 68396 16790 100042314 14863 14872 14871 14859 68214 56615 14874 211666 66447 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 108156 14450 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis 11689 16993 19225 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I 75986 242669 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II 12651 68671 99712 75320 28042 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis 107239 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 171567 75533 18103 79059 21915 56520 54369 22169 18102 66588 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis 11687 11684 625249 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) 23923 209027 19193 209692 12971 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) 77042 15586 74468 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis 22173 ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis 11972 108664 57423 66144 66290 11958 11957 11964 72325 11966 100039636 11947 66335 11973 11949 11974 230649 73834 17705 11946 114143 66043 11975 11950 100041835 432676 100039108 246782 228033 227112 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation 14287 270685 108037 108156 20425 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis 236539 100678 56433 107272 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I 104816 66514 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I 16365 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 231327 237823 14450 PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I 22245 68556 72269 80914 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis 74754 13360 235293 170738 14137 16987 14593 13595 110196 20775 319554 15360 192156 100040592 17855 15357 68603 18194 15490 73166 98386 110446 110460 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III 18263 11847 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation 72269 22271 76654 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis 15356 110446 15360 69772 71911 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation 68631 67880 58810 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis 18796 107650 18797 18798 18799 72469 18795 18802 74055 114875 18717 84095 269437 18803 234779 18718 52858 108083 18720 18719 67073 117150 224020 227733 269615 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV 68738 60525 11669 12359 11671 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) 13106 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation 12040 66885 12035 12036 15108 110446 13171 110460 13382 93747 12039 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis 11611 268782 ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 76267 56473 74559 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis 20450 20449 22234 14595 227671 14421 20440 54613 53625 14344 93961 14343 20451 57370 53418 20454 56375 108105 239559 26877 54218 26879 20444 56386 20443 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I 109778 394433 15369 15368 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III 27388 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis 56375 108105 56386 20443 20450 22234 14595 20440 54613 53625 20451 57370 53418 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 75540 234730 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 218138 THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III 29807 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation 64705 99586 103149 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation 66902 NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 192185 18115 CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation 110695 218865 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI 11534 PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis 12651 67420 68671 55979 12660 13026 14712 228061 99712 236899 75320 407243 28042 330450 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis 22173 L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 98256 71562 70789 266645 237320 107766 70266 209176 15930 23923 229905 56720 14719 209692 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) 13075 15490 13087 15487 15485 114664 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 74559 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation 211389 HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis 15186 GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis 20454 20449 22234 54218 14421 20440 20444 56386 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide 80908 26877 14344 93961 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III 11677 13106 67861 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis 11720 232087 108645 PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation 18606 68255 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis 171567 22247 69719 75533 56749 51797 55936 18102 18103 79059 56520 54369 22169 66588 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 69718 217837 75678 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis 108037 20425 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis 20249 171210 171281 171282 328035 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis 64292 67103 19223 19215 54486 77219 21391 15446 12408 100043508 19224 96979 19225 105349 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation 83493 72519 19062 320634 104015 16330 64436 16331 269180 16332 234515 234129 20975 101490 97287 19211 219024 74302 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis 106529 83603 56348 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) 71743 106564 66812 RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis 11687 11684 71932 11689 625249 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) 81906 13087 13106 71519 74134 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis 23887 64292 11687 67103 17001 19223 11684 19215 14865 54486 11689 77219 625249 21391 13479 15446 100043508 19224 96979 71932 72054 319446 13110 16993 106648 19225 56448 11688 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination 18602 18600 18599 18601 242726 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 18478 PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II 27388 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis 228550 320404 69718 19062 212111 320634 104015 16330 16331 16332 233011 20975 17330 19211 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis 76500 69718 227399 327655 75678 271424 27399 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism 107585 13371 13370 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway 50493 232223 26462 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis 11689 19225 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate 104112 KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis 67041 110446 69772 71911 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation 67689 66681 11670 72535 232449 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation 11687 11684 11689 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 12116 238505 64918 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation 107141 81906 13087 13078 13077 71519 74134 18984 20887 17161 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 266645 237320 209692 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions 14776 14775 67305 14782 625249 14778 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage 74080 226518 66454 59027 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation 76507 140483 CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis 67512 55979 110911 67216 102247 14792 74596 77582 14732 231510 52123 67469 28169 215456 68262 99010 225010 218121 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt 17330 12183 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III 338521 56794 11671 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis 14120 100043349 12183 14377 18655 21991 18663 68401 18648 56012 13806 18563 17449 17448 11676 14751 14121 13808 14447 13807 11674 230163 18534 14378 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I 237940 11669 17161 109731 11754 11671 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 66646 19895 21351 21881 VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II 106529 54325 56348 74559 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 76267 56473 20216 68801 233801 26458 56348 272428 94180 328845 14081 74559 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 69718 217837 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle 23887 68252 14630 66054 75475 14629 14854 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I 51797 55936 66566 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis 212032 15277 15275 110078 110095 19309 216019 66681 103988 232714 72157 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation 12040 268860 12035 227095 12036 66948 58875 13171 104776 13382 93747 12039 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) 231713 235606 67877 76773 11907 18203 56307 75624 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis 11689 19225 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis 76615 14718 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification 17766 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II 212032 15277 15275 216019 66681 103988 72157 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II 17161 TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II 98404 66078 68045 66637 76265 28088 104721 68215 67106 381802 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage 21877 22171 72269 13178 57813 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 75533 110074 21915 382985 18102 18103 79059 56520 54369 66566 20135 20133 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis 56454 69051 209027 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification 100042314 14859 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation 100042069 23917 107569 23959 230718 76952 11486 22436 18950 14544 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis 107869 11720 232087 269378 12411 108645 L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle 66902 11720 232087 104923 108645 20810 70266 67870 67873 56369 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation 20975 114663 242291 101490 55980 19062 212111 320634 104015 16330 16329 16332 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation 66885 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway 20481 218441 11480 12167 12168 12156 17128 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis 23887 17001 14865 11689 319446 13479 16993 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis 15497 15492 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis 14661 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II 19662 19659 22436 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis 14630 14629 14854 DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation 12846 17161 109731 11671 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis 11687 11684 71932 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I 76615 14718 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis 20454 53897 22239 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I 20322 PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate 16833 16828 16832 PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III 67689 11670 72535 11669 20229 17161 69215 109731 11671 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis 12716 12715 12709 76722 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) 60507 106248 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation 208982 15356 11992 72039 56357 12040 12035 12036 13171 13382 12039 78038 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle 14555 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation 104816 66514 11593 14718 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation 20887 11669 17161 11671 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis 11565 11564 11566 78801 11636 11637 229949 68870 635960 56248 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis 56360 70025 170789 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II 225845 66727 27281 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 98256 71562 70789 107766 209176 15930 56720 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis 67883 22235 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases 18796 18797 18798 18799 72469 18795 18802 74055 225845 66727 114875 27281 232889 18805 18806 269437 18778 18256 18803 26971 329502 234779 67452 271844 104759 237625 26970 665270 53357 26565 18783 18784 18782 18807 78390 66350 269615 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis 14137 20775 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis 78925 94224 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis 14630 14629 14854 14718 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis 71743 106564 66812 75735 211347 74450 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation 11676 69983 16548 225913 11674 21991 230163 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis 75456 19139 110639 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 22171 171567 75533 21915 18102 57813 21877 18103 79059 72269 13178 56520 54369 22169 66588 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis 12651 12660 13026 99712 236899 212862 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization 78914 74080 226518 98256 66454 58810 71562 70789 266645 237320 107766 209176 15930 56720 13195 209692 21990 11298 216343 13087 110446 110460 93747 20887 270076 11671 107141 81906 13078 13077 71519 74134 18984 11669 17161 109731 67375 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) 11430 113868 93732 20280 15107 15488 26458 74147 94180 15108 328845 93747 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine 58810 13195 109731 11671 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging 212679 70560 27267 23874 224805 71984 226414 85305 97541 70791 22375 216443 234734 107271 20226 15115 105148 68915 230577 226539 69955 71941 381314 107508 102436 67417 109093 110960 70223 22321 353172 66590 272396 71807 244141 104458 70120 107045 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage 216134 103711 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I 245847 67980 26384 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis 234724 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage 171567 75533 382985 18102 18950 11486 68870 56248 11821 15452 11565 100042069 23917 14923 11564 11566 18103 79059 11534 78801 56520 54369 11636 11637 229949 20135 635960 229363 20133 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) 93898 70750 104725 20773 13244 268656 228677 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 22171 171567 75533 21915 382985 18102 18103 79059 320685 56520 54369 66566 20135 20133 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis 171567 75533 51797 18103 79059 56520 55936 54369 22169 18102 66588 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine 108037 110695 20425 218865 74129 12116 TCA CYCLE%BIOCYC%PWY66-398 TCA cycle 20916 20917 11429 67834 18293 13382 66052 67680 66925 17449 17448 66945 170718 14194 78920 12974 15929 56451 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis 68327 14791 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation 20280 15107 52538 26458 13177 231086 94180 15108 97212 328845 93747 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis 93898 70750 104725 20773 13244 268656 228677 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) 74559 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II 20322 11522 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis 20454 108105 22234 26877 20440 56386 14344 93961 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation 257635 TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling 72562 13180 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis 20810 TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis 14528 20751 19286 L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) 98256 71562 70789 266645 237320 107766 209176 15930 56720 209692 110446 110460 93747 270076 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation 108155 76055 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis 15159 RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I 19662 19659 19378 11668 242285 216454 56847 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 20450 80908 14595 20443 76969 14348 14343 57370 53418 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation 171567 75533 18103 79059 56520 54369 22169 18102 66588 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation 72269 64705 99586 22271 103149 76654 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) 107585 13371 13370 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis 14595 53625 72077 14538 57370 53418 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) 13177 23986 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis 100043349 103988 212032 15277 15275 216019 18642 18770 56421 18746 18641 12183 18655 21991 18663 18648 56012 13806 11676 14751 13808 14447 13807 11674 230163 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) 107869 12411 HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis 56375 16770 14595 50935 20440 53625 14344 93961 72077 53418 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation 100042069 23917 23959 76952 22436 18950 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 22275 14151 19044 12892 MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle 78070 12896 57279 12895 12894 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis 22178 13190 22173 22063 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) 71147 223722 257633 70316 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation 14073 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) 11532 13885 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis 22234 239559 227671 26879 20444 56386 14344 93961 14343 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation 212032 15277 15275 58866 103988 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis 71932 13850 384214 13849 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) 77974 19771 19662 235033 19659 17252 241452 19892 20148 79235 98711 19660 19682 19661 28200 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis 15497 78925 94224 13074 15487 105349 15492 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis 100042069 171567 23917 14923 75533 18103 79059 56520 54369 18102 229363 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis 77974 19662 235033 19659 17252 241452 20148 79235 98711 15450 104158 67935 234677 63857 436059 69060 19660 28200 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis 11687 11684 71932 11689 625249 19225 56448 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis 107650 103199 18706 74769 18707 18711 18717 84095 104709 83493 75669 320207 52858 108083 18704 240752 18705 225326 18720 18719 67073 18710 30955 18708 18709 224020 227733 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II 212032 107652 15277 67980 74246 15275 26384 109785 54342 216019 14751 103988 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I 268860 214579 CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis 216019 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I 12583 14718 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis 170439 26458 70025 56348 94180 328845 14081 171210 171281 171282 74559 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation 268860 TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation 212647 56189 67432 14719 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation 106648 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 56473 54326 68801 56348 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis 16987 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 56632 67103 26458 94180 433323 328845 171168 14081 81535 54447 230379 11886 20698 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 66681 11486 18950 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation 72962 72269 22271 76654 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism 18796 269437 18803 234779 72519 18718 18797 18798 18799 72469 18795 97287 18802 117150 74055 219024 114875 74302 269615 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis 77337 83702 78925 94224 105349 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis 671878 FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I 270685 108037 108156 216188 17769 20425 107747 665563 17768 100039707 238505 GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation 14626 14933 235533 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation 110119 L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation 11720 232087 269378 108645 ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III 15452 11486 18950 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation 69590 14776 75512 14775 67305 20656 667310 12359 14780 14778 20657 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation 107569 23959 230718 76952 11486 22436 18950 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) 81906 13087 13106 67861 71519 74134 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis 56752 170442 192289 20425 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) 228550 320404 69718 19062 212111 320634 75678 104015 16330 16331 16332 233011 20975 217837 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis 11687 11684 11689 625249 11688 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation 69060 18947 16891 231871 16956 67717 15450 16890 116939 12613 66853 269060 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) 94181 12764 50798 67311 CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis 74451 66586 66461 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation 12846 CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis 14431 67092 UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) 22235 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis 270198 319801 18639 18640 170768 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis 14593 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) 22171 108037 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 78914 74080 226518 66454 67375 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis 70383 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I 24018 67897 DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis 12408 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I 19210 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 56473 54326 68801 56348 74559 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I 74246 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) 20450 14595 20440 53625 20443 72077 14538 57370 240119 53418 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III 13106 68738 60525 11669 11671 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II 68738 60525 11669 11671 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation 66904 17850 73724 110821 12040 13171 13382 12039 LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III 226413 12091 70893 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV 81906 13087 71519 14262 74134 55990 11761 14263 394433 226564 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) 74246 66681 319625 14430 14635 72157 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II 212032 14584 107652 15277 15275 109785 54342 216019 14751 103988 14583 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis 76282 108682 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis 11564 67054 108147 L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) 30956 110695 23923 209692 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis 214580 20768 109079 20226 211006 71984 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation 117147 26458 16922 56794 11671 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis 14645 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis 14593 110196 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis 68591 WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis 100929 329504 209584 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I 18778 18606 66727 27281 242864 56209 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation 66885 117147 110446 110460 93747 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis 78914 74080 98256 226518 71562 66454 70789 107766 209176 15930 56720 67375 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation 26458 94180 328845 14081 74205 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) 22117 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis 114874 18795 231871 269060 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) 11832 20531 64008 20516 20515 67768 20525 67674 18950 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation 81906 13087 71519 74134 13088 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation 11532 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I 66681 216558 72157 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis 11689 16993 19225 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis 56454 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation 23972 23971 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis 331026 14751 29858 54128 110119 69080 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 UREA CYCLE%BIOCYC%PWY-4984 urea cycle 11898 109900 227231 18416 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) 108037 20425 74129 12116 SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) 211389 59010 22117 HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis 22275 17025 14151 11655 19044 11656 12892 15288 22276 PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I 66904 17850 73724 110821 L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation 12040 13171 13382 231691 257635 12039 GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage 15452 18950 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle 11898 109900 18126 18127 18125 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation 12040 13171 13382 12116 12039 238505 14718 64918 211389 66904 17850 73724 110821 11720 107869 12583 232087 269378 12411 108645 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis 17025 11655 11656 15288 22276 MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway 68603 110446 319554 110460 15360 192156 100040592 17855 15357 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II 211488 106564 14261 ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) 93692 14873 DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis 55979 67916 216152 13350 19012 231510 50784 52123 67800 67469 68393 28169 381925 215456 229791 68262 235044 99010 225010 218121 67512 67216 102247 14792 77582 14732 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis 54391 319945 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 17330 69718 217837 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis 13166 18948 13195 21823 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 100929 209584 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I 246277 12583 14261 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I 11821 MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 17449 17448 14718 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor 75788 12393 76630 19877 17977 72183 18519 15529 18744 12447 57258 17222 16478 66313 20481 20482 56440 12530 67804 20682 20692 56484 20742 26409 21417 21781 211586 26413 21808 26417 21809 21812 26419 21813 216080 100041766 66105 22337 26416 103573 76793 227720 75465 67068 54709 52563 217232 69150 11909 69957 14106 12234 12442 230597 12505 24136 218210 56458 26399 21803 21814 18751 18752 17869 12928 11651 216869 11835 11848 26397 11910 19650 19651 17126 17127 18708 18709 12927 18753 14083 12566 20869 22062 22059 12387 13163 328572 13982 13132 71770 16842 433759 21402 15481 26965 16476 15239 17128 56438 68015 12567 12571 12575 68999 22601 66513 13018 26754 20901 218441 26411 71728 12534 12914 386655 19303 104394 14281 13559 13805 19645 23871 12443 14030 54601 14225 269338 14272 14282 20683 97064 12189 272359 99152 52206 15378 15405 69260 21815 16477 16211 17130 17131 17258 17260 12705 18044 18045 18046 18102 56513 56371 59008 56317 228026 18854 19042 71978 19085 19087 75901 12389 BDNF%IOB%BDNF BDNF 18212 26419 18803 23939 56637 26420 110157 16367 20416 13712 19229 271849 384783 18211 56484 26413 26417 11651 CCR1%IOB%CCR1 CCR1 26416 19229 18753 12913 14083 12768 18033 19697 19303 20302 20303 20304 20306 20846 22637 14675 20779 26413 26417 LEPTIN%IOB%LEPTIN Leptin 16367 384783 54611 18754 26413 20528 13649 26417 20218 16452 14784 20683 20848 667739 17979 19247 16453 192157 26416 16410 16419 16846 18708 16847 18709 18753 14083 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin 20848 56484 20416 233871 26413 17480 14388 26417 20851 16452 26395 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor 19273 71520 15461 67296 114715 114716 14936 16197 20662 56150 17179 17311 17342 21682 215280 22612 21933 54607 16590 56468 67300 15162 12703 20850 12984 14159 14191 26413 17096 12928 11651 26419 26416 18708 18709 11909 328572 16476 18751 18803 56637 110157 20416 19697 20846 20779 16452 14784 667739 19247 16453 20851 12929 13448 13685 56717 16331 13857 11350 14360 218397 14786 20111 18706 22376 58194 12402 208650 18750 CCR7%IOB%CCR7 CCR7 26419 12631 18803 56637 26416 19229 19697 56717 56484 56458 26413 12775 26417 11555 100039973 11651 100038965 WNT%IOB%WNT Wnt 22612 26409 11651 216869 26419 18504 19045 11848 18099 23988 22417 19052 18747 84095 320790 77578 20377 20319 18753 20664 22408 22413 22415 22418 22421 12387 14367 14365 12005 14362 14366 93687 16842 14368 21413 14369 14370 14371 16476 18751 18719 18752 84035 330938 21416 22416 84505 56637 12571 606496 19353 16480 54401 226970 13016 17125 13728 13542 13543 13544 13380 208846 67943 20378 231103 14734 192199 11789 12550 12443 16202 16971 16974 16973 18019 26563 26564 18750 FAS%IOB%FAS Fas 224105 50873 12362 320795 19877 11746 19090 12369 19106 66593 12370 72322 12028 12048 19687 20230 12122 12169 20807 56274 58231 12229 21454 12537 21841 21843 22029 22030 22031 26413 74153 22390 26417 12380 12366 12363 12368 223255 26430 56041 100042807 192656 14082 12633 17999 17193 26926 21945 98488 217232 26885 15170 16818 109333 56637 26395 14360 218397 17096 11651 18753 13163 93687 19353 26396 12043 17295 18810 22352 12367 11545 12371 19766 15507 333883 18570 19192 63958 66587 14084 27373 100039026 13001 67379 13347 21969 13665 75705 93692 11798 14102 14103 11857 17187 26408 15235 101706 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 22612 11651 11835 11848 17126 17127 18708 18709 18753 14083 22062 100039786 23844 12821 109620 13684 13844 13866 55948 16403 192897 16418 16773 16774 16776 16777 16779 16780 226519 16782 16785 19353 16367 19882 18479 20416 54401 74769 18707 30955 59079 384783 12015 20166 22627 22629 22631 18710 213435 18208 12476 20779 13649 14784 17295 18810 19247 22352 12367 13685 56717 11350 14360 18706 18750 NGF%IOB%NGF NGF 12912 327826 18759 13712 83945 26413 26417 26395 20683 HEDGEHOG%IOB%HEDGEHOG Hedgehog 22627 13363 24069 19014 75050 19206 15245 20423 319757 216869 19207 117606 70208 59024 110355 13548 18747 69792 264064 100041953 14451 269209 14632 14633 14634 16147 12387 GM-CSF%IOB%GM-CSF GM-CSF 12934 12465 14376 14827 59013 12051 20525 20740 22350 22612 15162 20850 12984 14159 26413 17096 26417 11651 26419 26397 26416 18708 18709 12927 15170 26399 21803 21814 18803 56637 606496 26420 110157 20416 13712 12015 19303 12912 20846 16452 14784 26396 20848 14388 20851 26395 12929 23921 19264 20112 22324 56324 14694 20844 57320 12675 16150 18643 18035 11757 12402 12981 20963 18750 12982 CCR9%IOB%CCR9 CCR9 26419 56637 26416 22350 225825 12769 16401 16421 17698 19684 20300 17123 12550 56458 26413 26417 11651 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 110157 26416 18479 20416 13712 14083 20851 26395 12169 18127 17973 13449 21687 21846 20850 14786 14159 26413 26417 11651 26396 CCR5%IOB%CCR5 CCR5 19229 19697 20303 20304 20306 20846 12774 11576 20850 26442 20293 20292 26413 20296 12273 26417 12504 11651 14784 20848 12631 26416 18708 15170 12675 16150 18035 20963 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha 16367 384783 20846 22637 20850 12928 20847 11651 226652 20848 20849 667739 15975 15976 26397 18783 18761 26398 20852 16451 13867 73086 54721 18753 20851 12929 13685 56717 22324 75705 56458 26399 18035 12402 TRAIL%IOB%TRAIL TRAIL 12362 19090 12369 66593 12370 12028 12122 18033 19697 21933 12912 26409 20779 22030 26413 26417 11651 12366 12367 11545 26416 14082 19766 12633 16151 26926 71609 50883 13030 12070 100039026 15270 11783 12387 27056 17210 11920 18383 670717 12018 11798 22333 65111 22035 18035 12042 105787 12402 NOTCH%IOB%NOTCH Notch 18519 26413 26417 17127 328572 16842 433759 21402 26965 15205 21423 11820 17128 20602 56438 13389 16449 14357 56637 14199 16396 56381 59287 15213 140484 13388 17125 15182 19664 16450 16848 18033 17305 19697 18128 18129 18131 18132 18133 20466 18550 100039623 54485 50754 55927 433586 100042305 19164 16452 19165 16656 20848 19763 27401 21885 22632 208117 270118 18222 60406 66935 20185 103806 M-CSF%IOB%M-CSF M-CSF 20416 12370 19229 17342 20850 11651 14784 20848 19247 22352 14082 19766 18708 210710 12977 18753 12978 20851 14083 23872 360013 209446 19201 17444 16331 13429 16332 12402 EGFR1%IOB%EGFR1 EGFR1 12390 56455 109711 54366 11502 101320 29875 54126 22687 19134 73178 29806 208177 68481 53859 12702 232431 54132 13549 194590 66952 23942 14924 21873 225870 20970 98910 238130 17775 330914 26431 78388 50926 12928 11651 11848 26397 17126 17127 18708 18709 12927 18753 14083 12566 20869 22059 13132 71770 433759 16476 15239 218441 12534 19303 14281 20683 21815 12389 16478 26413 26417 26419 26416 56458 18751 18752 17869 18803 23939 56637 26420 110157 20416 13712 19229 384783 18033 19697 20846 20779 13649 20218 16452 14784 20848 19247 14388 20851 26395 12929 13448 13685 56717 11350 14360 218397 14786 20111 18706 58194 12402 208650 18750 15461 20662 16590 67300 12703 20850 17096 12631 606496 19353 16480 54401 226970 13016 12550 26396 12043 17295 18810 22352 12371 19766 333883 11746 17999 15170 16818 109333 12821 109620 13844 13866 192897 18479 74769 18707 30955 59079 12015 22631 18710 12912 327826 18759 110355 13548 20112 22324 56324 20844 18643 18127 17973 13449 20847 16451 13867 73086 54721 105787 11820 16396 13429 16332 229615 12606 72993 227753 18760 19211 234779 100040260 20971 22325 12558 11308 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 12568 14251 74326 236576 24063 24064 57783 21787 67938 57257 108100 12608 24105 20499 26405 229709 19765 20867 399510 56460 69710 232910 12757 73379 19261 12988 216810 13014 12388 218518 74256 244418 11771 13205 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 13860 13858 11657 11674 240753 13855 229285 26936 286940 14252 98432 224650 23943 209039 105782 22378 80794 14302 235406 228136 104831 20399 19253 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 232906 26934 11740 13854 16952 12306 15194 215114 15382 628438 11804 16337 16400 16412 11836 67859 11843 110308 16687 110310 16691 16667 16668 16828 11855 16835 210126 109904 26401 26406 26407 17709 17886 17920 18003 11928 23980 50932 20403 13196 11949 67941 50766 72621 18596 54135 72201 18607 11431 18648 240752 18738 18746 67451 18805 18806 22038 74155 67760 54473 109135 171463 212139 71889 216190 235542 74255 170643 321022 230837 108079 19084 26362 18762 66898 23938 26400 19108 208618 93742 66166 76179 140721 20459 19246 19248 19262 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 666899 667618 667279 110651 67097 20194 20195 20239 394252 20969 53378 140579 71514 56726 20404 20408 230126 319939 381126 114479 20617 107686 20663 109552 109880 20909 11491 22042 21881 21894 21961 22051 22323 22330 108705 66395 244895 640703 60595 24066 319152 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 72828 227937 107435 30794 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor 12393 12362 17977 12369 18519 12370 12447 12530 12537 56705 12572 107951 56424 17978 81601 108767 12539 217127 13144 56710 13195 14797 11622 104156 14200 56406 192176 56218 14375 30051 68098 75273 11739 98053 68705 14884 223870 19183 15375 15469 14828 15519 16195 56637 11863 75352 17246 53610 18813 18477 57314 59004 18986 101700 214230 328365 12017 57782 19697 170758 19384 19822 18193 77627 225115 21804 20779 232286 22025 22026 22027 13649 22196 22353 107823 22596 20848 22668 627557 12317 17979 268903 52915 22294 23957 56469 12445 66671 107321 56736 12531 14694 57320 11651 11835 19045 17127 18708 12387 13163 328572 13982 433759 21413 15481 16476 17128 20602 19303 20466 19645 12443 20683 12189 12367 11545 15507 21815 21969 229615 12606 72993 227753 18760 19211 12389 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 20848 14388 14255 14389 11909 12912 12606 20850 26413 17096 100040260 26417 12402 16476 208650 11651 CD40%IOB%CD40 CD40 26419 20848 26420 16453 26416 18708 26395 16818 14360 12675 16150 14191 26413 17096 234779 18035 26417 16476 20963 11651 17869 TNFSF3%IOB%TNFSF3 TNFSF3 19698 18033 18034 19697 21937 21938 22033 16992 17000 16994 22030 22031 18035 16476 ID%IOB%ID ID 21416 11910 19650 19651 13712 17127 12566 19645 13713 13714 15901 15902 15903 15904 17877 15205 17927 18507 21423 19185 G-CSF%IOB%G-CSF G-CSF 12576 12700 12985 12986 14319 16188 18778 19696 20416 667310 20977 107939 12702 20846 15162 20850 18759 26413 17096 26417 16452 11651 14784 20848 19247 26416 16451 54721 20851 14389 12566 27373 16818 16331 20111 12402 20963 EPO%IOB%EPO EPO 606496 110157 15163 384783 20393 12015 319183 18127 56484 20850 54601 26413 26417 16452 11651 26396 109880 20848 19247 73086 14388 20851 26395 12929 23921 56717 22324 13857 56458 16476 20963 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma 110157 15395 15900 15979 16362 16363 19094 20375 20846 12608 20850 26413 13649 26417 12928 16452 11651 26419 20848 18783 18761 26416 20852 16451 12929 234779 12402 TNFSF1%IOB%TNFSF1 TNFSF1 16151 19698 18033 18034 19697 21937 21938 22033 16992 17000 230979 22031 18035 16476 11651 TNFALPHA%IOB%TNFALPHA TNFalpha 320795 12369 12370 53859 12122 22029 22030 22031 12366 107951 14082 12539 12633 56710 100039786 192176 15519 22627 22629 22631 12912 22026 22196 19698 18034 21937 21938 22033 14694 12675 16150 18035 20963 12051 19696 14886 11797 15516 16535 100039592 16648 16709 17218 17220 11651 26403 76784 18036 18037 20018 18567 18616 18637 245841 100043714 67857 73086 19173 19179 16151 19181 18753 71609 19182 70247 21762 22123 17463 66997 23997 228775 19708 77045 67891 432502 27207 433759 57751 21402 80859 27215 26965 64424 16476 20586 20587 20588 68094 57376 21926 21929 22034 22628 22682 66513 231130 236733 26754 20017 224619 15182 18201 230233 26572 56456 12914 12905 21934 12455 70834 233406 53376 17164 19645 211550 50797 21941 50754 226525 67384 20016 22032 56489 73174 66413 23881 227648 216150 21353 15185 72416 71833 56399 544963 333654 18789 56532 26410 446099 17846 109658 11652 14113 211651 76589 19414 14229 68652 103583 18854 16650 11647 66724 20019 56407 56312 12389 12091 20340 71966 69721 56480 26409 26405 26413 26417 26419 100041766 66105 26416 13205 12234 26399 26420 18033 19697 20846 20779 13649 19247 14388 13448 26401 26406 20850 18762 23938 666899 54401 13728 12367 19766 15507 14084 100039026 GDNF%IOB%GDNF GDNF 17295 19713 21823 110157 12532 19229 110651 12927 14388 14083 12534 26395 13448 19303 14360 18035 16476 12928 26396 TNFSF8%IOB%TNFSF8 TNFSF8 18034 19697 12051 19696 22029 21941 26413 22031 19698 11651 18033 CXCR4%IOB%CXCR4 CXCR4 14674 13983 23880 14677 26385 15894 16414 16428 16822 16885 12778 17973 20315 21785 22329 12767 56484 59025 12774 26413 17096 26417 12928 20847 216869 20849 12631 11848 26397 18708 18709 12927 18753 14083 15170 16818 15481 18803 56637 19353 54401 13712 19229 12015 18033 19697 19303 12912 20846 22637 20779 13649 16452 26396 20848 667739 19247 16453 20851 26395 12929 13448 19264 20112 16331 22324 14360 218397 12675 16150 22376 18035 234779 100040260 20971 12402 22325 208650 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 19225 18021 54720 16476 640703 56398 18018 18019 14281 104248 12981 16184 16183 15978 14103 53901 21947 381319 18986 14283 238276 14225 16477 16189 18747 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 16476 20687 18519 12912 328572 17131 20466 14462 12567 226519 12566 228839 17869 15481 14815 20683 17977 75901 245688 19650 17978 14106 56484 17260 56458 16419 12579 21815 15378 13390 14836 60406 16191 12575 11835 12914 11909 17927 11651 15228 20467 20482 22337 20481 21781 13982 18091 15182 433759 13559 76793 104394 21423 15977 12843 94112 59004 17187 54601 14534 18787 17126 17127 17128 100041953 20185 12608 209446 22642 19646 12393 13016 11910 12399 16153 12400 54123 12705 229615 14281 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 16173 16171 257630 18033 18035 20846 21926 17523 20849 20848 209590 329244 12702 93672 16452 16182 83430 16176 16400 20293 18126 16174 12501 54721 17329 18708 19697 16161 16160 18706 11686 16193 12504 16183 330122 15978 20850 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 433759 56469 103573 208727 22196 19384 17344 17246 19386 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 18720 53859 16202 16476 57257 26419 19353 16416 26413 19878 26417 19229 11848 12505 12675 16410 17390 26401 18792 17395 227753 18033 18035 18708 19697 14281 18706 12927 20963 20750 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 17128 26413 17131 26417 21813 13001 17129 21803 55994 11477 11480 12389 11481 12168 11482 17125 19045 13805 15901 21909 12165 16323 216869 21809 21812 14225 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 16367 20779 14083 16476 76829 26419 19353 12912 26413 26417 11848 17973 19247 20662 18708 15461 14573 14783 14786 18706 13448 14784 623279 12928 58234 18750 19713 14388 384783 20416 327826 19303 109905 12927 14585 114255 18747 218397 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 20969 12833 12832 26413 12215 12815 26417 12814 12831 94216 12830 83995 17393 15234 12361 20304 17395 14170 17295 12829 12828 12826 21803 12825 12824 64654 15442 12842 19035 16776 53378 14186 12836 12835 14184 12834 12843 18747 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 18754 240057 18176 16854 240168 56715 18015 640703 20662 18751 15461 54153 19395 12323 16852 225870 14784 18762 233046 74055 69601 18750 20663 20130 19415 19419 114713 19417 19418 16653 218397 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 20877 625328 16319 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 12703 20292 16186 16451 16453 12048 16416 15361 16165 16164 16992 15170 17863 16331 17864 20295 14159 11687 16190 20683 23871 56717 12053 18703 13449 16364 26416 245195 20344 20375 13654 18390 14128 21786 56468 21838 11846 16191 66596 11628 20851 12402 547253 20852 11651 14784 384783 12843 20416 16367 12608 16153 12842 12702 16452 18708 18706 20850 21947 16189 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 16186 16451 16453 19353 12048 17863 17869 56717 18033 56484 11651 15519 19247 16185 640703 20662 667739 18708 20597 19697 12043 16818 13669 18706 21752 14784 18762 22234 16184 208449 16183 14389 13555 20416 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 16186 16451 16453 11848 19247 16185 20662 15461 16818 14784 14389 232906 16001 14388 16000 107971 20416 18127 327826 18049 21687 18591 16911 16195 16194 16367 11600 22339 14677 15979 13645 18205 78405 18596 17356 94212 13649 15529 16542 110157 18211 18212 18213 14679 12064 26395 26396 20846 16452 18176 18708 18706 16193 16184 16183 15978 16653 18747 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 54720 20185 328572 12393 13016 17863 16542 17977 225182 14465 108058 14463 15251 103806 20602 20848 56381 22160 11545 12576 15214 16452 18128 11863 17172 22632 19645 11835 21885 12914 15205 19213 17927 14600 99982 14387 19664 14460 55927 15213 270118 11925 12504 433759 13555 21423 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 16420 16398 16421 241226 16411 213119 16416 16412 16414 16410 16419 16400 104099 381924 16407 16408 16409 16399 320910 16401 16403 16402 16404 319480 192897 109700 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 19046 19878 18817 228730 236930 11848 17931 20878 22390 19324 218294 269582 229841 72119 103733 99412 67141 107995 72415 20843 12531 67629 13605 12532 12235 56371 12234 16563 19348 19052 51792 100043703 18479 74498 78177 233406 71876 103583 67052 12534 18221 77744 12236 16319 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 17535 22195 18538 27354 22059 235559 100040608 12021 72775 19361 12566 225182 66105 22596 211651 14088 14087 14030 67030 11920 14375 12189 67337 60534 12447 19360 19090 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 14679 14677 14687 94226 11848 14673 14681 14678 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 20779 12912 18211 55948 54401 18753 22065 193034 216439 12015 12443 18803 12326 56484 13653 12322 100039786 22628 22627 22631 22629 18607 56637 18176 11651 20662 18708 15461 18706 14784 20850 14388 20416 18049 16653 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 16476 26419 16173 21803 20849 20848 16182 14969 14968 57765 12500 12502 12914 16362 16174 12503 12501 18646 16163 104156 12487 12519 12524 14281 26420 16184 12504 16183 15978 17344 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 22352 23980 215387 67455 71819 16765 19047 28114 21770 107589 242521 11848 20878 72415 12235 19348 67052 26554 70099 19167 14211 12419 11799 52276 54204 26934 12615 13346 320165 14020 20877 68298 625328 73804 218397 16319 18148 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 20779 14083 19353 26413 26417 11848 18208 17909 69635 13176 330662 107449 14360 22612 26395 107448 216439 26396 73178 18738 17755 18803 22253 140580 223435 12322 18479 17973 18708 18706 12927 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 14677 26413 26417 14687 11848 94226 14673 14681 14678 14679 18803 13611 14674 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 26395 26413 30955 18576 104709 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 19225 328572 20466 14462 17863 17869 15481 20683 23871 20375 18712 68652 11906 11486 545878 12575 12490 17217 12914 67155 17311 17927 12418 17120 12571 21426 15461 17132 12043 14863 20481 56463 12757 19374 16841 19152 12346 66513 12368 232087 18507 26409 12843 22761 17878 12578 16842 23872 67738 16790 15258 67972 11796 12978 20185 16590 12608 12847 11541 19208 51788 50701 12427 21849 18099 29875 18674 64050 19055 229615 12609 12606 22408 12443 17523 12576 18176 15205 14460 12504 22196 16653 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 20779 14083 19353 26413 26417 26395 13845 73178 13844 270190 22041 104015 13429 215449 13643 13642 13641 13640 16443 26921 545156 19877 13846 18176 18479 17973 18708 15461 14786 18706 14784 12928 20130 20416 19303 109905 16653 218397 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 20779 11796 26419 12675 26401 26416 18607 14082 19687 12229 14102 67300 11651 12122 12367 22350 18708 20597 16150 72393 74769 26420 26399 18706 26400 12370 16151 19766 19094 14103 11797 26414 12633 20963 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 20873 20620 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 21937 114774 11796 67384 18590 26419 13645 228355 229317 26926 26413 12028 58994 26417 18201 11886 26398 13033 110157 670717 12905 17869 26401 18753 26395 26396 18033 12015 18035 21926 26921 14082 19645 11651 12122 20597 19697 12043 18762 12370 19766 16000 56632 71609 22030 23992 19106 16706 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 20779 22195 21770 19229 14773 21823 18796 18753 14360 17096 22612 19144 15162 50873 12015 12143 30931 67847 57320 22223 13162 56424 100039026 14191 20617 18805 18806 109731 16818 14225 20963 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 12234 20779 12051 19696 216869 18708 16150 19697 16818 18706 18033 18035 26416 20963 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 18720 16476 26419 16412 19878 11848 26398 17931 12576 18805 18806 19877 105243 320795 109333 11909 20404 320271 14064 22350 18719 20807 22330 20544 14281 26399 56513 11459 18762 29857 21894 12631 16007 223701 19211 18717 19684 17698 13367 17906 16885 12704 16886 26397 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 16416 11848 14360 22612 17096 15162 12143 12389 14191 20851 11651 16818 13448 14784 12928 20416 18591 16367 12977 20779 64177 19246 12978 12991 13645 12988 14131 12333 18596 50490 19116 24064 13649 16334 16846 16847 16797 19109 14158 22166 16337 12558 22608 20848 12702 16452 54721 18708 18706 20850 16399 12927 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 20779 16398 26419 16412 26413 12028 26417 11848 15529 17390 12361 18753 14170 385643 13844 14268 60409 16774 21803 57916 269587 64654 16772 12390 14694 53378 14186 14184 18015 12367 22350 15461 12981 18747 218397 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 320139 18176 26413 26417 18751 15461 110157 14281 26395 18750 16653 26410 109880 13712 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 16476 26419 12048 12912 328572 26413 26417 12567 17390 21823 18792 26416 11846 11909 12043 13982 18750 12189 16334 11910 12400 12443 12702 20724 21808 83430 20174 18218 19017 19645 63953 18126 18595 15205 26914 20339 18015 16478 81703 13008 15132 12123 14281 26420 12428 26554 71355 81601 16193 19252 240672 15978 19094 13198 11423 13197 18986 16477 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 13837 20779 13835 13637 57257 13636 53972 13836 13638 11848 14360 17096 22612 15162 12143 18803 30955 104709 13640 14191 19877 12402 16818 12928 442801 12568 12929 13842 13840 22325 13841 13839 13838 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 21937 18519 328572 68346 17131 75387 20466 14461 27374 56233 15185 23942 15184 30795 64384 75788 70465 93759 216848 245688 232232 19016 17191 107932 64383 21422 22025 170787 229512 70315 50721 12234 209011 234366 60406 17119 79221 15183 229542 12914 17192 20467 15182 433759 22761 17187 100041953 20185 19646 18033 18035 21926 20602 20848 22632 19697 14460 103573 208727 22196 19384 19386 18747 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 18102 16398 105504 20528 241226 211446 213119 16412 16334 16410 18805 18806 16400 216859 67300 211914 12876 53413 70834 22319 30948 11555 12000 12387 20336 104099 30957 69940 12550 56044 107371 18717 16593 22095 16401 12385 16403 11845 16402 11607 16404 12388 319480 66482 13430 109700 24044 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 26419 93687 18519 27401 214897 328572 64143 19651 18817 12359 20393 20656 15235 12566 12675 252870 14377 55948 22682 54401 67731 12125 70425 93759 103236 12053 27373 104318 56484 56458 100039786 22628 22627 22631 12576 22629 12914 11651 16150 26420 12387 14103 56044 103573 26414 13197 19384 54601 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 14676 14677 14687 94226 14673 14681 14678 14679 14675 17250 81535 14739 13611 56632 14672 14674 14682 20397 20698 13610 13609 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 20779 20528 12048 12675 110157 55948 54401 56717 12015 56484 56458 100039786 22628 22627 22631 12576 22629 18607 210789 56637 78757 16646 56716 12575 606496 12371 23797 227743 11651 15519 11652 26408 54601 18747 19090 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 18102 20779 16421 19353 17356 11848 29875 12443 215449 11651 21872 18708 76884 107746 11767 13383 18706 12387 242687 21844 226541 12928 16480 16407 12550 13043 50884 11308 18717 12385 11845 109905 22325 12388 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 110355 226861 21808 20423 19227 14451 13363 14633 216869 19206 11651 18708 18706 57810 16976 15245 117606 19207 14725 20460 16147 319757 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 20873 12795 18817 20620 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 18720 16476 26419 19353 68089 67771 26398 26403 11867 56378 66713 74117 26401 11855 224105 18796 13058 241275 192662 13057 108100 101314 26416 17970 76709 83767 329165 71893 17969 237038 404710 18479 11909 18719 12387 12928 12631 12550 18717 12385 16885 26397 29875 20848 76884 26420 26399 26400 242687 20850 50884 11308 26934 12927 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 14686 12790 76376 19682 245650 243923 14695 77974 30952 78600 14697 170735 107477 14913 24013 19892 19739 79235 110855 14710 14919 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 18102 20403 73341 227377 57257 109904 53972 219140 319899 216963 75974 11789 192662 18803 16443 70497 210293 236915 26934 29815 54126 19765 52666 22325 71972 228359 17207 14163 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 22339 13636 328572 14254 17387 67923 18655 16542 112407 112406 20525 26357 11792 22346 20683 23871 16341 93759 20893 18999 17684 18174 13856 13819 14297 319594 11540 22160 13712 11863 12914 18787 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 16476 26419 18519 328572 14461 26398 56233 14815 17977 93759 17978 26416 56458 22025 19696 11835 12914 67155 320795 15519 433759 20779 12606 13653 14694 20588 11614 52915 217127 59035 56637 21848 18585 30051 20181 20183 20182 223870 22026 66884 57376 50528 15408 110147 26399 68098 15502 81601 18986 17246 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 16451 16476 18595 20662 18708 20807 107746 16410 14281 18706 230126 14784 435684 12391 12928 18803 12929 20416 12389 100039026 13712 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 20779 14184 13649 12361 14360 14170 20970 13043 18976 19164 11604 17202 100042305 64654 13004 59287 19242 208117 100039623 14186 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 100040260 19225 102626 271457 73389 16476 17165 22059 12608 18783 12912 17164 15507 13714 14567 17346 17258 13685 16691 13684 17342 56613 226641 73086 26416 17260 19017 18126 11909 20544 13982 19094 13198 22278 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 20779 14083 19353 16412 216963 19229 330662 12475 67374 14268 17242 12520 17882 270152 21825 19084 21826 19085 22329 140559 22631 19262 18749 13522 21894 12928 11308 16401 11845 19303 12927 18747 20750 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 22408 73016 84035 14367 192199 26564 70495 13380 16974 14362 22415 14366 22416 16973 22413 22418 14370 68588 22422 14371 22421 14368 24117 14369 57265 16010 20187 93897 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 18021 16476 12912 328572 14461 17863 17869 21823 14815 18792 20683 17395 23871 21803 16191 11909 17132 12534 13982 11459 12387 16007 19211 12843 12578 230899 21416 17134 67405 26754 14284 382056 22059 14282 13614 22051 23857 13709 12017 11770 11910 17750 13406 16153 83995 21857 12400 18619 11606 15007 12125 14609 12443 15251 13653 12576 20293 16478 18018 18019 14281 12981 16193 19252 16183 15978 14283 16477 16189 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 16452 16191 20851 19247 18708 18706 14784 17096 12700 16192 12984 20850 53378 18712 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 73341 16202 16476 19353 12912 17931 20878 29875 64099 21961 12443 12539 76142 56212 140579 18938 170736 57342 11545 26431 67268 56505 22793 56637 78757 17974 20174 75786 21335 68458 67444 225341 21417 11651 15519 20613 109711 12387 103573 54126 13367 19303 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 19246 26419 19353 11848 14158 14609 12558 227753 18803 19877 19247 640703 12005 18708 14800 16573 16973 13191 12325 18706 12387 231871 14182 12801 16480 14432 13043 13589 269060 18717 12385 17906 12388 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 218772 19411 19401 20186 22260 17977 19016 21803 21926 20602 20181 20183 20182 22337 12043 22259 20787 11303 19015 19014 67544 21834 21833 19013 15370 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 22061 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 16476 69191 328572 24068 18996 18997 12266 22433 13033 116870 12675 22200 15500 17869 11764 18002 11785 11957 17977 78330 13508 27410 23957 17978 55960 268395 18667 268527 12006 22192 66949 224903 12822 71990 667310 12521 211329 268903 11737 17979 13983 114604 100041004 67488 212391 12034 671392 67040 13982 433759 12189 16911 17128 18538 20185 12608 19109 12443 20602 11614 20850 208727 19014 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 26419 19353 16412 26413 26417 17390 14159 14360 23871 13449 26416 56458 18806 12575 20851 18479 11651 17973 19247 14786 18815 14061 14784 11601 11602 12928 231130 69257 50915 14173 12169 20416 18127 19303 21687 11607 218397 11600 14083 13709 14268 18033 21926 13712 18708 19697 18706 20850 16402 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 18021 16186 16476 26419 26413 26417 16185 15461 18750 13656 14939 21936 22163 21942 230398 12010 18761 12525 12526 15976 15975 13813 110157 15007 26395 26396 21926 13653 20849 109880 13712 320139 18754 12500 18176 12502 12503 12501 18646 640703 18751 18018 18019 14281 26420 16184 16183 15978 14103 14283 16653 16477 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 16476 26419 19353 16412 26413 19878 11848 26398 16410 330662 14360 23871 22612 73178 140580 16419 18479 17973 20662 22330 14786 11459 14784 21894 30957 12928 232906 12169 54126 19303 109905 218397 20779 14083 71302 213498 245671 110596 13196 20405 24000 12334 110157 26395 12443 18803 215449 109880 26431 17974 109711 18708 107746 26420 18706 20130 16402 12927 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 16777 16779 16774 16403 16772 226519 16780 16776 16782 192897 16773 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 17535 27354 235559 100040608 72775 69928 19367 19718 19356 69263 15574 67196 12190 235610 15270 12649 237911 330554 19355 74335 12234 101831 230484 21975 237211 71885 12144 208836 15205 104806 67561 68275 106344 103583 72151 233826 19891 211651 14088 14087 67030 11920 12189 60534 19360 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 17535 21415 72433 14284 26362 73389 56436 110308 22061 22601 64058 21973 15201 12442 12831 55948 12609 12190 14694 18128 56637 11486 16400 15205 22337 18987 20997 16175 16396 50754 14776 12062 16664 226849 13395 11920 107568 56437 16009 17246 12578 67815 14104 211323 20913 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 22352 21937 228355 12028 11820 11857 101706 670717 20740 12905 14453 57913 26401 20230 11783 12362 227753 12366 16668 12363 66593 12632 12369 20874 21418 16907 11798 13368 13347 16905 16906 21969 12043 11459 12368 14939 16885 14083 11796 21926 11545 12371 18646 12122 12367 12370 19766 11797 20787 71609 22030 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 73341 57257 109904 53972 219140 19353 319899 330662 192662 140580 223435 545156 216445 109934 16800 277360 24001 94176 110279 229877 23853 20662 13860 22324 21844 70497 11308 26934 54126 19417 19765 19418 52666 22325 228359 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 16414 11848 15235 17390 18792 17395 15162 67374 18033 17882 21926 215449 20344 21838 19877 15894 11596 18815 238055 20345 19882 16193 21894 14219 83964 434174 18791 16409 18793 16971 109905 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 18102 18720 18805 545156 18806 19353 26413 26417 11848 21844 18793 53869 11840 215445 11845 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 16476 26419 18783 26413 26417 26398 16331 12675 26401 14360 224105 17096 18806 12402 11651 19247 20662 15461 22324 13448 14784 14389 20416 19012 19303 19249 50928 215280 56743 218397 14127 14126 14125 14083 16822 15163 18778 14130 208650 16428 110157 16797 14158 26395 26396 18033 18803 20698 13609 12229 18751 18708 16150 19697 18019 14281 18706 26400 16151 19252 20963 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 20779 22339 14677 19353 26413 18596 14254 12767 26417 14687 11848 14673 14681 14678 14679 14675 14672 14674 14682 13610 14676 16452 23797 11651 18591 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 16421 14083 16412 16401 17123 11848 19303 22329 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 19353 26413 26417 11848 330662 140580 19247 20662 15461 14784 12928 14389 14388 107971 20416 327826 18049 109905 17207 218397 18205 78405 18759 100040603 94275 330914 18211 83814 18212 18053 18213 216148 17179 12064 23873 26395 20418 11350 19762 12443 19769 18803 67903 13429 56212 98878 215449 83945 20848 56470 18412 18176 18708 107746 18706 18762 21844 12929 19417 16653 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 20779 19353 16428 20393 11848 16331 16797 14360 17096 22612 15162 12143 18803 56484 30955 19157 104709 19159 14191 19158 106952 18607 17060 234779 22637 16332 11844 18176 12229 83436 101476 231821 15519 26377 18708 15461 16818 74769 18706 19211 11840 11845 109905 16653 20963 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 20185 22601 26413 19116 26417 19109 14360 68652 16452 20851 13874 18183 18708 80707 15200 74769 14812 11491 18706 13869 14784 13866 16396 12223 13385 12398 20850 83961 17999 100042150 16206 107568 20416 17246 211323 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 26413 26417 16331 110157 17096 12700 26395 12984 26396 20846 20848 22631 18712 18749 16452 20851 20293 18176 19247 20662 18708 15461 16150 14281 18706 12981 14784 14389 20850 12982 20416 15900 18413 16653 20963 18747 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 29857 16765 12443 320795 20648 65964 26415 26399 26397 13631 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 19294 69697 210126 17309 13636 211446 17920 13645 11828 13836 11830 216963 233765 65970 17356 20909 22323 13649 16582 11848 15234 17295 22793 19877 17973 109711 76884 22330 12387 20336 12550 50884 16001 11308 16000 18717 12385 13367 11845 17906 12388 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 16416 17164 26413 26417 19229 15170 11848 15239 19271 16410 15516 14159 22370 27371 14360 224105 11640 226101 19255 207565 12562 26416 12389 12402 11651 17973 15519 19247 103583 22330 14783 12387 14784 18750 14388 11840 18127 12385 19303 13430 26397 20779 22339 14083 14254 16542 110157 29875 18753 26395 26396 18803 109880 18607 17974 19877 640703 18751 18708 26399 18706 230126 19094 17999 18747 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 15361 328572 12028 12567 116870 13684 17869 17395 69719 20425 67154 12530 13681 11757 109115 216185 20713 108143 18712 66464 15510 14732 100088 100043349 208643 72504 12914 12151 56426 15519 21429 67025 59026 380669 12444 16828 13557 21752 67014 72195 64602 66942 22042 75597 18642 13806 15902 13665 67065 68632 17187 12035 18103 14534 18263 56456 18102 15525 17127 170676 17128 100683 27354 21877 22059 20525 56505 20174 20613 81601 11799 14283 18148 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 20779 18481 22034 19353 26404 216527 64143 19091 70686 26406 26398 14360 224105 17096 22612 15162 12143 26416 14191 18218 63953 18479 16818 26399 19252 19766 66513 19094 56044 26397 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 12703 26419 26417 15170 17342 17096 56484 12914 12402 17311 11651 19247 20662 15461 22324 12043 14783 13448 14784 19211 14388 20416 16590 26411 21682 20583 110157 16923 240752 14158 17444 114715 17179 114716 56792 26395 23921 26396 13857 12015 19277 20846 13856 20848 16452 18607 56637 18708 18706 20850 12929 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 20423 26419 19206 12159 18550 14178 14734 26420 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 20779 22339 19353 16412 14268 11490 22341 22329 11489 20229 16516 74145 21923 21817 11495 11501 212503 18126 14205 12981 104099 12982 19303 12927 20750 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 227525 319583 59047 21673 54125 72103 75570 66408 56626 108138 22596 14375 19090 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 271457 16476 26419 19353 26413 26417 11848 26398 16331 13685 15239 19271 13684 26401 224105 23871 56717 19255 73178 18479 12402 20404 11651 17973 19247 14064 20662 15461 56513 12387 14784 12928 14389 12550 14388 20416 12385 11845 19303 109905 20779 14083 19246 11789 18759 110157 15234 17295 26395 26396 12015 18803 13653 215449 18607 17974 56716 16332 11652 20613 18708 107746 18706 18762 18222 97998 16211 70584 224116 58194 226970 74030 12929 74370 13858 67605 74334 12927 56705 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 20779 14083 14677 19246 13645 26413 26417 15170 13649 14679 227753 73178 20846 18803 20848 17974 18176 18479 17973 19247 20662 18708 15461 74769 18706 14784 21894 14388 18717 20416 16653 218397 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 14702 14062 320129 14677 18797 67804 16801 56440 14688 18795 19878 75547 22323 109689 14687 11848 14673 14681 14678 18796 18753 14679 192662 14675 13429 14672 14674 14682 14676 22793 19877 320795 14064 18751 18708 18706 14061 18750 18127 17906 18752 13430 22068 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 14083 19353 16412 12767 14177 11848 21788 20971 20315 66911 18753 20304 17395 14268 17242 16774 57916 67903 21825 16772 11489 53378 21923 109711 18815 14061 14182 18750 14173 14369 16402 13430 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 26419 18519 328572 27374 12566 18002 216080 65019 23988 53892 225055 67956 13163 100043295 26416 26374 17248 219022 13560 110750 67773 226830 50883 69181 73251 333654 19052 12450 110854 12914 11651 67025 59026 11920 12578 15258 22059 93687 27401 214897 21849 252870 18753 70425 103236 27373 11350 104318 12649 56637 22632 26420 12428 68098 81601 17246 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 19225 18021 19246 16476 208650 14462 12567 19016 16364 21926 13653 13654 16191 57765 17254 19272 12477 13655 66889 12367 22778 640703 13139 17132 20371 18018 18019 14281 12981 16396 16184 16183 15978 13555 14103 21947 13656 381319 18986 14283 16477 16189 18761 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 12387 16480 12550 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 14676 16367 14677 16476 26419 19353 18479 26413 26417 14687 11848 14673 14681 14678 14281 14679 12562 14675 26416 14739 14672 14674 14682 13712 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 14702 20779 14083 14677 18797 19353 12912 14688 26413 18795 26417 14687 110157 14681 14678 18796 14679 26395 26396 18803 234779 11835 11651 18708 15461 14714 75273 14281 18706 20415 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 22059 12795 12532 12447 50883 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 18021 14284 16476 328572 23857 83995 17390 18792 14609 20683 17395 12443 16774 20293 16478 18018 18019 12428 17313 15368 16193 13179 353170 16878 21824 22282 18793 11911 12843 18127 14283 12578 16477 192897 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 17535 27354 13016 21849 54401 19367 225182 19356 11350 26374 12530 15270 12532 50883 21975 12144 227525 12122 108138 81601 211651 13006 11920 20184 70681 12189 17246 24061 93765 27223 240087 19360 21750 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 22029 21937 53859 11796 67384 26419 12675 670717 12905 11783 12366 18033 18035 13163 21926 12369 14082 12371 14102 12503 12122 12367 26408 19697 12043 26400 12370 19766 14103 12368 12633 71609 22030 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 20387 117149 20201 13003 17087 106759 12111 16179 108960 21899 21898 11848 142980 20210 12675 20202 24088 21897 266632 17874 12475 15510 16150 16151 434174 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 16451 14462 16173 16171 50931 20847 16162 16159 21803 20846 246779 21926 50498 20849 20848 16452 16176 57765 54721 16161 16160 16193 16183 15978 20850 16195 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 26419 19353 11820 11848 12675 670717 11783 192662 66593 11798 18749 11651 18815 13555 12368 20416 18049 11796 22059 22034 18205 78405 16179 18759 94275 17393 18211 18053 12125 17874 12064 12015 18550 17984 17136 68585 18412 20661 72843 22627 192656 12070 75625 18377 170936 19716 20598 66647 12371 11852 11853 235402 17392 12367 18708 16150 26420 11491 18706 18762 16151 11797 26414 19164 100042305 59287 208117 100039623 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 56637 14367 606496 214897 11789 16974 72293 12005 13542 18719 240756 22416 13544 13543 71810 26554 12387 84095 226849 12389 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 20779 16476 26413 12393 26417 24064 19229 15529 18792 17395 14170 12558 20846 18803 64654 12322 14186 18607 14184 20851 12402 11651 19247 20662 18708 14281 18706 20111 14784 14182 231637 14164 70584 83379 12550 13043 171463 17967 18793 14183 14388 20416 327826 12388 20750 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 17128 21909 17129 11705 55994 11477 110542 12162 14225 12168 17125 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 84704 114774 215114 18813 57257 225115 15382 50523 57908 75502 56406 104263 19229 627557 12445 14228 22200 22215 18095 21413 232286 18477 56218 227753 328365 17152 72993 17978 21815 268903 11835 11651 12571 20807 75273 12387 22596 14375 12189 59004 12578 19090 229615 12443 59035 99982 50528 12370 56469 22196 19014 227292 110651 56705 14200 21804 76804 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 18720 22793 20779 19353 11651 11652 13649 22323 11848 18708 18706 12387 14360 16480 12550 16475 12374 18803 12385 12388 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 16476 16451 12608 19353 12048 26398 21857 17869 17342 18753 229615 12609 15162 20846 16803 26416 17210 22027 20848 99571 56458 19267 21943 12702 232345 12944 16452 16362 11651 54721 19247 20662 18708 22324 14281 26399 18706 14784 16193 14389 19094 56469 14388 16477 16911 16195 16194 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 13837 13836 13842 13840 13841 13839 13640 13838 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 27354 235559 18817 19361 12566 54401 269582 19367 19718 19356 69263 15574 12530 12190 235610 12649 12532 22631 19355 12234 17220 72930 214552 19052 17216 51792 23834 66131 54380 21853 68275 106344 103583 72151 19891 12428 211651 17246 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 12234 56637 93687 14367 606496 11789 26965 16974 21402 12005 13542 22416 13544 13543 12387 27373 104318 12006 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 16367 14083 19246 110157 18753 12015 14694 22627 22631 18607 17974 11651 18760 19247 20662 18708 15461 14783 18706 14784 18762 12928 16001 16000 384783 20416 12929 19303 12927 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 16176 26413 26417 640703 71914 26398 195046 69538 26399 26400 16173 12362 26395 26396 21926 18667 22329 26397 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 19682 245650 243923 77974 14688 14697 107477 14913 212541 24013 20215 19892 225600 19739 18587 79235 14699 214111 14685 14919 12788 18588 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 193740 18021 14451 27401 328572 18817 12442 12567 12566 17869 17390 20683 26395 12443 12190 12531 50883 606496 19645 12914 104156 12534 14281 12428 13982 11799 18005 54124 108000 12615 14235 12616 12578 22594 16775 20877 12447 21802 15379 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 14702 110355 227288 271457 18797 14688 18795 109689 14678 18796 17096 15162 14675 13429 30955 104709 14191 14676 18805 18607 18754 12402 216869 11651 18751 18750 18752 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 16456 21810 78369 16411 15896 14131 100689 110135 16414 14161 14723 12266 14058 19123 18792 385643 99571 22329 21838 15894 381924 83964 16007 16408 18791 16409 18793 21947 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 20528 19047 20909 16334 18759 106628 240028 50518 55948 22318 54401 104215 14936 16337 140491 100039786 22628 22627 22631 22629 210789 56637 11651 11652 640703 18762 20913 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 271457 16476 18783 17869 14360 22612 23988 73178 30955 104709 20851 12402 13860 16818 232906 16971 18591 13430 18596 17356 94212 110157 29875 26395 26396 11350 20846 215449 20848 20698 13609 16452 17974 18708 76884 107746 74769 18706 26400 242687 20850 13043 50884 26414 11308 110651 12927 19106 16706 26419 19353 16416 26413 26417 68089 67771 11848 26398 11867 56378 19271 16410 66713 74117 17096 19255 192662 15162 108100 12143 101314 76709 14191 72930 19052 51792 18479 17973 19247 20662 15461 20807 14783 13448 14784 12928 18750 19211 14388 20416 109905 218397 20779 19246 12988 55948 54401 18753 20491 65962 21345 20469 26941 18803 69710 98910 19341 214384 100039786 238130 22628 60595 22627 109880 22631 13712 22629 18754 18176 16478 14281 26420 16653 22325 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 11477 14225 11482 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 19294 20779 16456 14083 227377 19353 16416 18596 17356 29875 16410 215449 12737 58998 58235 19274 18708 107746 18706 12387 21894 12928 12550 18717 12385 109905 18591 22325 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 16476 26419 19353 26413 26417 15170 16331 12675 26401 23871 17096 26416 100039026 11651 20662 15461 13448 14784 19211 26409 20416 218397 12988 22034 14130 94212 26411 110157 19055 26395 18033 18035 13712 18607 17060 234779 24056 12047 19057 240354 12229 108837 108723 19264 26377 18036 12517 640703 12518 18708 16150 12478 19697 18018 15985 12483 14281 12325 18987 19056 18706 12042 16151 22325 20963 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 102098 207212 57257 109904 53972 16801 213498 110596 75547 11857 11848 11855 192662 69710 223435 13605 12576 106952 216445 109934 16800 110279 23853 22324 17925 72754 69632 171207 232906 11856 213522 14570 442801 117600 71704 94190 50768 52666 234094 22325 56349 73167 17207 223254 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 22249 20910 20614 20979 20907 11435 22318 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 328572 18129 18131 14462 18132 13388 13728 50530 56309 17869 16449 225164 11487 14357 17150 13389 18011 227325 16450 13386 12805 16924 54485 53870 12234 12575 12402 26965 21402 433759 13806 53869 20185 27401 19208 13016 225182 12443 18550 13429 103806 20602 56381 11489 18128 22632 99982 19664 270118 18222 16396 50754 100042305 13858 59287 208117 16189 100039623 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 17242 71951 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 16186 16451 16453 12048 13709 16992 12445 17869 20683 20851 18646 19247 16185 12571 20662 18708 20371 12043 12444 16818 12428 18706 14784 16184 16183 14389 20850 14103 20416 16189 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 20779 16476 26419 19353 26413 11435 26417 110157 56717 26395 26396 12015 20848 84092 18016 67588 16452 13867 11448 73181 67299 18176 11651 19247 20662 18708 15461 74769 14281 19056 26420 18706 14784 13866 26414 100042150 20416 16653 211323 18747 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 14702 271457 18797 14688 18795 22323 109689 14678 18796 17096 15162 14675 140580 13429 30955 104709 14191 14676 18607 18806 19052 51792 19354 12402 12765 216869 19349 94176 11651 18751 18750 53869 18752 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 15376 15375 15377 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 20969 20970 15529 20971 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 22339 16456 21810 20969 16416 110135 18596 14161 94216 226519 12830 16542 20971 16410 22370 16777 18792 21813 12829 14268 12828 12826 21825 99571 12842 20698 21838 21923 15891 14118 16728 18613 13612 16423 16007 434174 18793 16399 12843 18591 16775 20750 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 14061 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 12703 16186 16476 16451 26419 16453 17164 26413 26417 19229 11848 12566 17869 14360 13449 26416 20851 19247 16185 20662 15461 12043 16818 56324 14784 22780 20844 14389 216233 384783 20416 218397 16367 110157 12700 26395 26396 20846 20848 12702 18754 18176 18751 18708 14281 26420 18706 16184 16183 15978 19094 20850 16653 20963 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 14733 14734 71951 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 21853 20893 27373 53610 11865 12953 12952 12753 140858 18626 12649 18627 217166 18143 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 12703 16186 56717 26416 19349 11909 20852 16185 16818 14939 12010 26397 20303 12525 14938 12526 16177 17873 18034 13813 15284 23882 12774 19698 15007 16173 18033 16162 16159 20846 20849 20848 192656 16452 16182 14969 14968 16176 57765 12500 12502 18126 16174 12503 12501 54721 19697 16161 16160 14281 26399 16184 12504 16183 15978 20850 14103 56632 16189 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 16420 16421 20969 21812 17123 14118 16410 13612 22370 18792 16007 14268 18793 320910 16401 16419 22329 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 16202 57257 19353 16416 26413 26417 19229 11848 16410 22370 21813 12402 11651 15519 19247 22330 13612 21894 16001 14173 16000 12843 19303 16367 12977 20779 22339 16456 14083 12978 20969 12833 12832 12815 30924 12814 18704 12831 78560 94216 17304 12830 16542 224020 107650 12829 14268 12828 12826 12825 12824 12842 12576 12836 12835 19877 12834 18708 18706 12370 12927 20750 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 22059 18519 328572 12028 22151 60525 64384 22143 17261 50709 93759 15395 68738 64383 56484 56458 209011 12575 19017 12914 17927 208727 14375 14200 54601 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 218772 19411 19401 26419 18519 328572 26413 26417 17977 19659 17978 17420 26416 12572 66671 20602 15183 268903 20181 20183 17979 12914 20182 11651 22337 12534 433759 18750 18752 18747 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 26754 11863 22059 15519 67923 112407 112406 22346 15251 71745 12578 53417 319594 56292 14694 216440 56438 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 20387 20423 16476 12608 328572 16334 22433 18095 11764 22370 11957 20683 78330 13508 20703 12576 12822 11819 320951 667310 14526 20390 22287 268903 18029 11835 72082 17979 12914 18027 15376 114604 15375 100041004 15377 14281 238055 13982 18986 12189 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 26419 93687 19353 11848 18099 22612 19016 12322 68652 19877 14367 26564 216869 208846 192176 84505 13542 320790 13544 18019 13543 26420 22418 18762 68588 66513 26414 14368 26409 14369 57265 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 14702 20779 14677 18797 14688 18795 19878 14687 11848 14681 14678 17390 18796 14679 17395 14675 14672 14674 14682 14676 18176 13983 11651 20662 18708 15461 268980 14680 15200 75273 18706 13982 14784 19094 16001 16000 20416 18127 17698 16653 12927 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 21415 67772 16543 14175 16476 73389 67087 99377 72693 81004 328572 18014 64406 73739 80334 12592 59024 12291 17869 17390 17342 21413 17395 17978 12006 12234 11835 13380 26965 21402 12444 21752 12387 15182 433759 16007 12550 15902 12578 16842 21416 100683 13003 11789 13016 20583 55948 54401 12443 12326 100039786 22628 22627 22631 22629 20174 21885 13544 17709 21414 20997 140486 21886 20586 234130 21372 11513 103573 665113 16600 21888 17877 14797 16678 17928 77578 18741 16319 12590 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 26419 12048 15170 21682 16331 16923 17096 18033 13857 20846 18803 26416 13856 12702 16452 234779 20851 12402 12229 19247 20662 18708 15461 12043 107746 14784 20850 14388 384783 20416 12929 109905 22325 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 17873 22034 19353 23882 216527 26406 269881 53608 26401 22166 330177 216965 26407 26416 68652 26408 640703 12323 26399 66513 19094 13197 11920 26409 22030 26397 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 100683 73389 27401 22642 17869 224105 23988 18854 109115 216185 108143 66464 56505 56637 20174 19052 12005 81601 72195 50754 226849 12578 17187 14534 56456 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 19225 22339 14677 19353 26413 18596 26417 14687 11848 16542 14681 14678 18796 14679 17250 18803 18591 20698 13609 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 17126 20779 22339 14254 11820 14360 17096 22612 20563 21813 15162 11905 19122 12143 620395 21803 16772 14191 21809 21812 16818 14182 14733 14173 211323 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 16476 18797 26419 19353 18783 26413 18795 26417 19229 11848 18796 18755 26416 70086 224129 11512 11514 11515 13617 13616 13615 104110 13618 58861 432530 210044 105243 104111 11651 15461 20544 12928 18750 12843 18761 20779 14677 13614 14687 14673 83995 110157 14681 14678 18753 14679 26395 26396 14675 12825 14672 14682 14676 16452 18754 18751 14680 14281 11513 12927 18752 22068 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 22339 14205 18654 18187 14254 18186 14257 22340 22341 16542 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 16476 26419 19353 18759 26398 14360 73178 12015 18803 17974 216869 11651 17973 14064 21872 18708 12488 170643 74769 54631 26420 56513 170484 18706 14784 18762 26414 22068 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 14702 16476 18797 19353 16801 14688 19229 11848 17390 17395 17096 224129 11512 14674 11514 11515 104110 18806 432530 210044 104111 11651 18760 15461 65086 14745 78134 53978 12928 11548 14388 19303 20779 14083 14677 22051 13649 14687 14673 14681 14678 18753 14679 65962 18033 14675 18035 18803 14672 14682 14676 56637 18754 12367 18708 19697 15200 74769 14281 21844 11513 12927 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 16398 241226 213119 16412 226519 16410 22370 18792 12475 67374 17242 12520 21825 21826 99571 22329 140559 12822 14118 114249 121021 18793 18073 12843 16775 22339 21810 12833 12832 110135 14161 12815 12814 12831 94216 12830 16780 16782 16773 16777 16779 12829 14268 12828 12826 16774 12825 12824 16772 12842 16776 74145 12836 21923 12835 21817 12834 16400 104099 16401 16403 16402 16404 319480 20750 109700 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 14289 20779 14293 76701 19353 16416 16412 110135 18596 16414 14161 50701 13649 16410 22370 15234 330662 18792 17395 14268 21803 99571 16419 16400 17392 18815 12928 16409 18793 16971 56640 14756 13035 16402 22359 17381 12927 17386 71785 18787 14294 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 12912 16412 328572 17869 20683 19650 56484 20375 12579 12575 15183 110854 13380 12043 22418 433759 15902 12843 12189 17187 17126 17127 17128 14581 21374 94280 15360 12192 22642 18596 18044 18045 18046 12759 13435 22084 18173 66271 14319 23894 20304 12609 29811 12606 17988 229663 21873 20377 12443 56752 17122 56363 12576 21673 16852 13866 13198 13197 12633 16403 15900 192897 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 13867 13645 15519 13874 13649 18183 15200 13869 13866 12223 83961 100042150 11839 211323 21802 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 14702 110355 14688 14461 56233 15185 15184 22151 54401 14815 22143 12053 232232 12326 17260 20602 68558 170787 19727 71458 22627 79221 15183 15519 20807 14460 13982 103573 208727 22196 19384 19386 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 229317 22601 17131 75788 18854 21813 13163 21803 12389 11798 19045 68652 19052 216869 21809 21812 20662 56513 12387 14784 14219 66513 26409 20416 17126 17127 17128 83814 12322 22627 66313 21814 17872 18607 73122 240025 20742 68010 71978 218441 67068 93836 19053 20901 12005 230597 13132 16396 107568 14225 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 16421 16407 12550 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 16822 16476 26419 18751 26398 26411 16797 13169 26401 17444 12928 26409 12929 26410 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 18021 54720 26419 12048 328572 12028 26417 26401 18755 26416 100039026 18712 12914 12043 18750 18761 93687 55948 54401 18753 17261 12015 12326 100039786 22628 26410 22627 22631 22629 56637 18754 12367 640703 18751 56398 18018 18019 100039592 26420 227720 104248 14232 18762 16211 53901 103573 19384 238276 14225 18752 18747 15370 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 53859 15170 16331 12675 14360 12402 11651 17973 19247 20662 15461 22324 16818 14784 14389 18750 19211 20416 109905 18761 64177 16822 12988 22034 16428 94212 26411 16797 17444 18803 26410 18607 14969 14968 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 192176 18751 12487 16150 19395 12519 13169 12524 12042 54354 16151 22376 12504 109305 24055 53416 20866 23880 19419 77799 16653 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 22339 26413 14254 26417 216148 18803 15251 12389 18607 12402 18654 18187 11651 17973 15519 18186 19247 640703 18751 22340 18708 12488 18706 18750 18127 18747 218397 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 14784 56717 13645 13614 20416 13649 20662 15461 13617 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 14702 14634 67661 14677 20423 19335 100041953 93687 214897 14633 14688 19206 19646 20466 14687 14681 14678 18753 14679 70425 26395 103236 27373 245688 104318 12234 56637 60406 12914 216869 16854 15376 11651 20467 103583 15182 433759 56469 103573 211401 269209 24069 20747 16568 21821 18747 319757 14632 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 16367 105504 19246 211446 20411 16334 20393 18759 106628 16331 13685 104215 16337 23921 56484 12389 19262 18607 17974 12402 11651 17973 11652 19247 14064 53413 20662 18708 15461 107746 14783 56513 18706 13448 14784 18762 20336 12928 69940 50915 107371 20416 66482 218397 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 18590 54635 18595 18596 18591 71785 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 20779 14083 13636 57257 16332 19353 13836 11431 12402 18479 11848 18708 18706 14784 21844 232906 20416 22325 12927 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 100040260 23980 271457 16476 12048 12912 19060 11843 23938 56419 17907 23939 26405 19730 22695 67603 56613 73086 56717 73178 17260 11909 11651 667739 13860 56044 13645 13649 110157 29875 26395 26396 20846 20848 78757 56716 227743 18708 76884 74769 18706 242687 50884 11308 110651 16706 26419 19353 26413 26417 68089 67771 26398 11867 56378 66713 74117 26401 27371 108100 101314 76709 17125 18805 18806 19052 51792 14064 20662 15461 20807 20544 14784 18750 14388 20779 12334 55948 54401 18753 12015 98910 13653 100039786 22628 22627 109880 22631 13712 22629 18607 71978 18176 640703 14281 26420 225870 18762 19252 16653 22325 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 19353 21770 11848 100040603 29875 18472 13424 56430 23924 12570 18476 11350 13131 17755 13193 83431 18475 19699 12569 27226 100039026 22627 640703 18221 12568 16976 22359 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 19352 19245 20779 19877 12575 19353 16412 26413 11853 26417 11848 12566 12428 11606 22143 13653 19244 12927 12447 56187 107503 109700 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 20779 26419 19353 16416 26398 14360 17096 22612 15162 13844 270190 12143 13429 13642 13641 14191 50780 17974 13846 18708 16818 18706 21844 16399 26409 19249 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 16398 12912 16412 26413 26417 26398 14268 26416 12842 22341 14205 11651 14257 20662 18708 18706 20111 14784 12928 19094 12843 20416 16401 16402 109700 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 20779 13636 13645 13836 16416 216963 109689 13649 15234 17295 14675 14672 14682 19159 19158 14676 78618 16554 320495 16867 216869 216859 50753 212285 231821 17973 70676 232227 11555 16399 22095 11845 19303 11607 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 16451 22061 22601 328572 12028 12795 18817 12566 17869 16190 20683 23988 93759 12366 18854 16450 26416 56484 12235 18749 11486 12575 12571 22062 12237 319618 12534 30948 16180 226646 229933 21945 15499 22431 22142 14252 11576 18196 12018 207742 23886 19012 63958 68048 18611 12448 268882 18787 14651 223752 56612 19361 18211 55948 83814 12125 11350 12190 12649 14694 20703 15214 19645 14102 80707 19697 14460 12428 68098 81601 16396 19094 17246 14104 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 14702 20779 20292 14677 56066 56744 12766 55985 14688 26413 15945 26417 109689 14687 110157 14681 14678 14679 56717 26395 26396 26416 13429 18607 78757 56716 18176 227743 11651 17329 18708 15461 74769 26399 18706 19094 16653 26397 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 12608 12048 16188 27058 194231 16331 12700 12984 22628 22631 18712 18749 16452 15901 20851 19247 18708 18706 14784 433759 14389 20850 20416 18413 18747 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 110355 14702 320129 19353 16801 14688 11848 14360 18796 22612 17096 15162 12143 18755 26416 14674 30955 22329 14191 104709 216869 11651 14697 170735 15894 16818 18750 53869 18127 18761 20779 13645 19091 13649 19222 21390 14673 19214 14678 18753 14675 26941 13429 14672 14682 14676 21817 19877 18754 20339 18751 18762 19094 20963 18752 18747 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 13645 19353 16412 13649 226519 15235 16780 18858 16782 55948 12821 16773 54401 12527 16777 16779 17295 16774 12369 16772 100039786 22628 16776 22627 22631 22629 13867 20181 20183 20182 11651 18708 15461 18706 16175 14784 19882 13866 12550 18750 20416 16403 16775 192897 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 26413 26417 13685 12566 670717 13684 56430 56717 18854 13681 12234 18805 18806 11651 103583 15461 18750 12447 16367 20393 22084 110157 55948 54401 12421 64930 75705 26395 13629 26396 22241 54170 18569 109270 73826 52187 29869 100039786 68441 22628 51897 22627 109880 74747 22631 100042570 22629 106298 18607 245670 78757 56716 22632 19017 18176 227743 16150 20111 97998 20787 74370 67605 16653 13631 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 12234 53859 18034 18033 19698 12675 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 16476 12048 13836 64058 328572 57913 11783 20683 12362 12053 26374 110750 12450 12575 12914 13380 15375 22062 22337 12043 21781 15182 13555 16878 12368 11576 12018 23886 14534 18787 13003 13649 11910 74747 26921 20312 19079 21933 242705 19645 71887 15469 14102 107986 12177 12122 27056 29813 14149 66824 57748 21981 68428 13207 20586 14000 71361 235281 268973 14775 13496 382985 15194 67941 17246 12607 209456 218215 22178 20750 17685 66813 59092 17350 60599 12050 22061 319801 140742 12028 12227 12795 18996 12142 18997 18861 15248 20400 13033 66214 94223 69076 17390 12454 21354 18854 17210 12389 108143 12822 13615 12521 13557 19211 21802 193740 18538 100683 22059 18044 11789 18045 18046 20583 22084 55948 15234 17988 17295 20724 59035 12047 68098 19252 240672 12062 13197 16009 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 104110 18754 432530 210044 104111 12912 14680 78134 73086 11513 224129 11512 11514 11515 18747 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 18102 20779 271457 19246 13645 19353 56440 15170 13649 15239 14673 29875 17393 18212 19876 11487 14360 16002 12064 12558 104836 17295 109620 17288 11350 63955 20562 56805 14674 12914 19349 17392 12367 15461 14573 12387 21844 16480 12550 19713 16001 74030 12385 11845 12388 14585 13430 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 22059 216963 21770 20878 72119 18035 16475 83431 218977 100121 12531 66077 18245 12877 56371 56637 75786 21335 18479 11651 11799 13197 19384 12615 54126 12189 17246 320165 20877 18747 218397 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 22029 53859 11796 16476 26419 16453 22034 12048 208650 26398 17869 26401 18033 18035 26416 30955 104709 22031 64435 56196 21939 21929 11651 18708 19697 74769 26420 18706 19094 20850 11797 26414 21947 22030 16189 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 71990 236193 20587 17979 13983 12266 57376 22200 18002 20586 17977 23957 17978 22192 11614 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 20878 20877 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 17128 22059 12912 13728 13033 22084 55948 17869 54401 64930 56717 12539 100039786 22628 22627 22631 22629 56637 56716 12283 75770 20869 19165 15519 70661 232944 22350 71728 381979 70415 66993 17691 13982 72149 235344 74343 18612 227154 74370 67605 18747 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 13846 13845 13844 270190 13642 13641 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 18205 12912 17164 26413 23938 26417 23939 26405 110157 18753 73086 193034 26395 19762 19769 26416 98878 13653 215449 17260 12569 109880 13712 18176 15461 20807 14281 26399 20111 12568 109905 16653 26397 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 22029 21937 11796 67384 228355 18201 26406 18759 12675 26401 22166 18033 20846 21926 12389 18412 14694 68652 26921 21929 14082 20598 26408 20597 16150 19697 11491 26400 18762 12370 16151 19766 66513 11797 26412 665113 27206 74256 26409 399510 225028 67338 71609 21938 22030 26397 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 11364 22228 22139 11370 18609 12894 12608 15107 12912 71911 234724 230163 18534 16334 20526 20927 16514 21869 14377 16006 15227 14815 12609 21405 20683 12606 11655 103988 11657 78070 13386 15378 15376 11651 15375 18015 15377 14061 22042 11576 11806 100040592 12895 18770 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 16476 26419 19353 26413 26417 68089 56419 67771 26398 26403 11867 56378 66713 74117 26401 224105 22612 56717 73178 192662 108100 26416 76709 404710 18805 18479 12402 11909 14064 53413 13860 15461 56513 12387 12631 12550 12385 54126 17906 16885 16886 26397 20779 73341 11789 110157 29875 15208 51789 18000 226751 18508 109880 56637 18754 18708 26420 26399 13383 18706 26400 18762 21844 70584 19417 22325 12927 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 110355 14702 18797 19353 14688 18795 19229 15170 11848 16331 15239 20315 14360 18796 17395 22612 17096 56717 15162 12143 56458 14674 30955 14191 104709 20851 18479 216869 11651 19247 170735 22324 16818 12928 12631 19303 16885 20779 14083 14677 12988 64143 12767 94212 14687 14681 14678 14679 20847 12015 20846 13429 215449 20848 26385 20479 14694 50778 116733 56085 16452 18607 14969 78757 14968 56716 12500 12502 11852 11853 12503 227743 19264 12501 18708 74769 18706 18762 16396 231637 12504 20850 12927 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 16985 102626 14009 17164 12912 15507 20807 110157 22084 55948 21823 54401 19094 21423 26416 12531 100039786 22628 22627 22631 22629 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 16476 93687 26413 21770 11789 26417 13016 13388 18099 17869 11487 21405 14357 22408 12443 100039026 12234 18128 56637 73016 56811 93960 14296 21885 12914 13380 16974 14362 13542 12005 103583 19664 14281 12387 433759 66513 19164 17999 24117 26409 100042305 19015 14797 59287 208117 100039623 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 20423 73389 22061 64058 328572 12028 18817 17304 12675 16449 18753 20683 18854 11350 63955 100039786 13654 12234 20724 11486 12575 16400 192119 22032 14102 20833 18294 21420 73472 20148 16150 14149 14027 22337 18104 66993 229933 16396 14776 14252 13197 107568 23886 17246 16009 12578 68048 192897 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 12703 16451 15979 12608 328572 26413 17131 26417 26403 69635 26401 18753 12362 19255 56717 26395 108058 20846 215449 12322 20848 16452 16176 12402 12914 16362 11651 19247 640703 18708 107746 12323 96979 12325 16391 18706 15978 56469 12929 59004 109905 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 18720 18806 19353 12847 13196 12757 56041 107338 228998 12504 76932 11771 11773 56494 68137 74325 11840 260302 19158 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 73914 16177 16476 26419 22034 16179 26406 18759 12675 266632 12362 17874 18033 18412 68652 16176 18708 16150 19697 16180 26399 18706 16175 18762 16151 66513 26409 16181 54473 93765 111173 16178 66589 225471 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 22088 74551 18514 16476 12640 26419 110308 14229 68094 12912 19060 83797 328572 26413 12028 12355 22354 26417 225888 14462 100043429 18736 14228 16667 14815 17977 17978 26416 20375 99571 12569 18749 16191 12575 20851 12914 11651 15519 15894 15182 433759 11576 12991 21374 22059 20393 83995 19109 55948 18033 20846 13653 20588 22629 56637 57765 16362 20339 16163 19697 18018 14281 26420 12981 16193 20586 16183 15978 19094 20850 18976 26414 16664 12568 18986 17246 16189 18747 15370 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 22088 20779 271457 14083 13645 208650 24064 13649 15239 110157 100041766 218038 13854 216080 70527 231125 66700 104015 13429 84092 16443 18176 12402 20404 20662 18708 15461 74769 18706 14784 66105 58194 16206 20416 54126 13858 16653 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 73389 18519 328572 27374 15248 12445 12566 17869 18792 11783 20683 93759 17215 18968 104158 19650 234677 20859 12369 12530 17865 17210 22294 83767 20135 20133 22171 12580 13909 19385 56353 67935 52679 50496 12575 23834 436059 13361 12914 67155 211586 18392 22062 12534 21781 13557 433759 13559 13555 104394 11920 12189 12578 22594 12447 12448 14534 18787 100683 21877 235559 209446 19646 19651 21849 12606 225182 12576 22632 242705 19645 12428 12419 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 21937 12234 21929 240354 22034 257632 16150 19697 12675 12042 66105 16151 18033 18750 11797 18035 103573 74256 21926 11920 19384 111173 192656 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 14360 13839 13640 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 53859 15170 12675 14360 12402 11651 20662 15461 22324 16818 14784 18750 20416 109905 12010 18761 12525 64177 12526 16822 12988 22034 94212 16797 17444 15007 18803 26410 18607 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 18646 18751 12487 16150 19395 12519 12524 12042 54354 16151 109305 20866 19419 16653 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 16476 20687 26413 20466 26417 22215 17869 20683 56717 245688 21803 229512 60406 17119 11651 15519 22427 208084 20467 28113 245474 101185 21749 497652 13982 21752 103677 21951 15182 22596 22431 15381 433759 98999 13555 11546 57321 72400 100043508 11920 14375 17187 19360 21750 17535 17127 15976 100041953 27354 13645 19646 13649 19367 18033 11350 12443 15574 22627 12576 19355 11819 12144 16362 14281 16183 15978 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 16476 328572 12567 12445 12566 17342 93759 19016 26416 17260 20375 14836 19052 20587 12575 15183 12914 11909 17927 12418 21429 12571 12444 21781 13557 433759 13555 104394 270627 18505 14312 12578 19660 20937 12447 13433 12715 56321 223922 21374 12608 27401 19646 13709 12393 13016 110157 12609 12606 17295 11350 12443 12576 21808 20390 242705 19645 26420 12428 12981 20586 19094 17246 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 17126 73122 17127 218210 17128 19042 69274 26413 26417 640703 100039592 227720 26401 16211 22196 227292 59004 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 16476 12912 328572 16414 14461 56233 20315 20683 23871 17977 17978 17210 15378 21786 13805 12914 11651 16828 21752 15368 22042 13806 15902 18787 26754 17127 22339 17128 15277 13614 15275 79362 11520 12767 14151 230099 18671 16846 18655 19883 112407 11535 12870 20525 16006 23959 26357 72157 18746 18641 103988 17988 11674 170768 20893 17684 22041 18550 13856 15251 100042570 11863 18126 14281 18148 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 26419 16412 26403 18472 14360 14811 13131 19099 17755 19699 12569 56637 17974 16800 16400 12402 11651 18708 107746 14812 18706 26400 12568 16976 12929 22359 109905 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 21933 14082 26419 26413 26417 26398 18708 20597 16150 12675 74769 18706 26401 12370 16151 19766 65111 12633 22035 71609 22030 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 14702 19094 26419 14688 26416 12918 14680 26420 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 12977 20779 22339 19246 16451 12978 16453 13645 229317 16412 18596 13649 16334 16542 15234 16337 19255 17295 20846 70361 19341 20848 20851 12914 20852 20662 18708 74769 100039592 18706 14784 16211 20850 56469 14388 20416 18591 19106 109700 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 17128 19042 69274 26413 17131 75788 17129 12159 55994 66042 17130 11798 18121 12168 66313 11625 12156 17125 68652 17872 69585 19045 12161 56637 12166 12667 68010 68799 12622 218441 244058 23892 14313 20481 227720 66513 26409 12162 227292 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 14676 14702 19877 14688 19878 14065 14064 11848 14061 18796 14675 14672 14674 17906 14682 FSH%NETPATH%FSH FSH 26396 12640 11652 14308 14309 72993 14772 26385 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog 22627 19207 117606 70208 59024 69792 264064 100041953 12387 110355 13548 14451 269209 14632 14633 16147 216869 13363 24069 19014 75050 18747 19206 15245 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor 433759 15507 11651 14083 11835 18708 12912 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor 19085 13163 19087 75901 75788 76630 19303 72183 12443 15529 18744 57258 17222 20481 56440 54601 67804 20682 20692 16478 20742 12189 21417 21781 211586 17977 21803 21808 21809 21813 21814 216080 100041766 66105 22196 22337 103573 76793 17869 227720 75465 67068 12399 54709 52563 69150 69957 12234 12442 230597 12505 24136 12530 22062 218210 13982 216869 433759 11651 14083 11835 18708 26411 12393 56484 14281 14282 16476 16477 20683 18607 20869 19645 22059 11909 12928 21402 12927 26965 12389 66513 18519 56438 26397 26399 56637 218441 23871 11910 19651 18706 13132 71770 68015 12567 12571 12575 12447 68999 22601 13018 26754 71728 12385 12386 17691 56458 268288 386655 104394 13805 18709 14030 14225 269338 14272 17872 97064 272359 99152 52206 15378 15405 15481 69260 16211 17128 17130 17258 17260 26413 12705 26417 18044 18045 18046 18102 56513 56371 59008 56317 94093 228026 18854 19042 71978 TCR%NETPATH%TCR TCR 107321 12519 12524 26558 73341 26431 12534 140580 14389 22388 27277 26396 12387 13548 11651 14083 18708 12912 11909 12928 56637 18709 26413 26417 19303 11486 16923 27387 19419 19395 56324 57257 98221 12608 20218 12469 71520 100039786 12675 30925 329693 83490 67300 26410 12914 12929 26416 12477 74039 13139 13205 13367 13430 94176 13448 12934 72349 269378 13653 13807 22154 13837 107508 19229 14158 286940 20430 320150 104248 12488 11350 23880 14381 101540 19260 14569 16797 54390 52013 53416 14784 107746 13169 232906 54167 12306 11744 432467 15516 81489 16150 16331 16428 16438 16453 12521 16818 16822 16828 16832 11857 240028 17085 17096 17829 17973 104112 18003 11928 18018 18019 232975 18033 18035 18036 18295 18479 20403 23853 77647 14026 56233 18613 227707 11431 18648 72157 240752 224020 18746 18803 234779 234374 233315 240754 74195 77853 170643 19056 18753 94212 56444 18760 59079 23939 26419 19094 26395 93742 140721 70737 15170 19247 19248 19262 19264 545902 11459 110157 19384 109905 218397 19697 71911 53378 24055 230126 20416 20491 20637 20662 20663 20779 20846 58231 20963 21682 22042 22088 22145 22165 50493 22323 22324 22325 22376 215280 22631 22637 108705 217069 22142 640703 72482 108723 72828 227937 78473 12402 208650 11502 192656 12523 54126 19134 12042 54353 68481 171543 13449 27371 19200 22248 12481 15239 13549 12500 12501 12502 16800 12504 12507 12516 12487 17444 LEPTIN%NETPATH%LEPTIN Leptin 20218 56637 12675 20416 105787 20779 20846 108079 18754 20112 20528 13649 18035 16370 13685 14360 606496 13684 667739 16367 16451 13866 17977 12568 12632 12944 20399 14682 192157 100705 18803 16001 234779 16419 16846 16885 18127 54611 11651 14083 12393 14784 26413 26419 13982 16150 16453 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor 13685 14360 667739 12566 11651 12984 14159 18708 15461 18750 15162 328572 16452 18751 26419 12703 16476 14786 20111 14191 58194 16590 16197 19247 22612 11909 56717 12928 17342 19273 67296 114715 110157 114716 13857 14936 218397 56150 19697 17179 17311 71520 56637 17698 19684 20850 29857 20851 18706 22350 67300 20662 21933 54607 20779 56468 12929 20846 26416 21682 22376 215280 11350 208650 26413 16331 16453 BCR%NETPATH%BCR BCR 13685 14360 606496 667739 12566 15162 18751 20111 12675 12572 12929 23921 26416 240354 208154 13712 14130 18717 240168 56792 19253 13448 14886 17060 15163 15387 16439 18021 77590 30955 18718 670717 242248 18761 12028 101476 83436 12053 20303 20848 12229 56743 117150 21432 18720 18719 108083 12369 14784 77799 107746 12371 17164 12483 12517 12518 15985 16150 16428 16438 16818 17096 17973 18003 18019 12387 18803 11651 14083 18753 12912 26411 18760 56484 14281 14282 16476 16477 18607 19645 15170 11909 12928 12927 218397 19697 56637 24055 20416 20662 20663 20846 21682 22324 22637 18709 108723 12042 26413 TNFALPHA%NETPATH%TNFALPHA TNFalpha 13649 16367 18750 328572 20850 14886 12028 12369 17164 21353 15185 72416 71833 56399 56338 544963 333654 18789 56532 14084 12539 67338 67067 100039026 446099 17846 11652 13057 56710 109658 14113 19698 211651 76589 19414 14229 69807 192176 103583 16650 11647 20019 56407 56312 29864 12091 20340 15182 71966 69721 56480 22627 11797 11796 11798 16535 100039592 16648 433759 16709 15507 17218 11651 17220 14083 26408 26403 12912 76784 50754 17931 18037 20018 18567 18616 16476 18637 16477 245841 100043714 54391 58994 19645 320795 23938 66593 21402 19173 19179 26965 19181 19182 12389 70247 66513 21762 22123 17463 66997 26399 23997 228775 19708 12051 77045 67891 432502 27207 12122 68015 57751 80859 64424 20586 20587 20588 68094 57376 21926 21938 22026 22166 22628 56458 22642 22682 231130 236733 12366 20017 224619 18201 16151 26572 56456 12905 14082 21934 12633 52440 12455 70834 233406 53376 211550 50797 21941 226525 26413 67384 20016 26417 22032 56489 73174 66413 23881 227648 216150 26406 666899 16396 228026 26405 18854 68652 66724 67857 26420 73086 19696 22034 230233 15519 14694 14388 12048 20181 54401 107951 13867 13728 22629 12367 22033 100041766 66105 22196 12234 100039786 26410 12914 26416 13205 13448 14784 15516 18033 18035 18479 26419 19247 20662 20663 20779 20846 22631 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 14388 54401 22629 13649 12367 13685 12015 14360 19353 18479 23844 12821 13684 109620 13844 16367 55948 13866 16403 192897 16418 11848 16773 16774 16776 22627 16777 16779 16780 226519 16782 16785 17126 11651 17127 14083 17295 11835 19882 18708 18753 18810 18750 20166 22352 213435 59079 18208 14281 12476 74769 16476 18707 18710 384783 22062 19247 22612 56717 100039786 20416 18706 20779 26416 22631 18709 30955 11350 14784 26413 26417 WNT%NETPATH%WNT Wnt 12443 54401 18019 13728 19353 216869 11848 18747 11651 18753 18750 18751 26419 16476 19052 17125 16842 18099 22612 16480 26409 226970 93687 13544 12550 13380 208846 67943 20378 14734 16971 16973 26563 18504 23988 19045 21416 84095 320790 77578 18752 12571 20377 20319 20664 13016 21413 22408 22413 22415 22418 14367 12005 14362 14366 14368 14369 14371 84035 330938 84505 18719 IL6%NETPATH%IL6 IL6 13163 26396 15519 17096 14388 14389 107951 13867 54601 18033 13685 12015 14360 19353 13684 16451 13866 17977 18803 433759 15507 11651 11835 18708 18753 15162 328572 56484 14281 26419 16476 26395 14191 19645 19247 18099 26409 26399 56637 20850 20416 20851 12914 20846 26416 22324 56458 18709 19229 54721 21939 229615 15382 16193 12402 16194 20848 16195 12229 26407 26398 12169 229317 20393 12702 14784 26413 26417 TSH%NETPATH%TSH TSH 26397 16001 26399 16846 12912 11928 14674 105782 14672 14673 14677 26417 14678 14679 14681 14828 22095 12317 16150 12330 110157 14682 EGFR1%NETPATH%EGFR1 EGFR1 13196 11949 67941 50766 72621 18596 54135 72201 18643 18738 67451 18805 18806 22038 74155 67760 109135 171463 212139 71889 216190 74255 321022 230837 19084 26362 18759 109333 66898 26400 19108 208618 19211 66166 76179 19246 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 667618 667279 110651 67097 20194 20195 20239 394252 20969 20971 140579 71514 56726 20408 319939 381126 114479 20617 107686 109552 109880 20847 20909 11491 21815 21881 21894 21961 22051 22330 66395 60595 24066 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 107435 30794 12390 56455 109711 54366 19766 101320 29875 22687 73178 29806 208177 232431 54132 194590 66952 23942 14924 21873 225870 333883 20970 98910 238130 17775 330914 78388 50926 26396 72993 13548 433759 14083 18708 12912 14281 16476 20683 18607 20869 22059 12928 12389 26397 56637 218441 18706 13132 71770 56458 18709 26413 54601 16478 17869 12608 20218 67300 12929 26416 13205 13448 19229 286940 11350 232906 16818 16828 17096 17973 18003 11928 18033 18479 20403 11431 18648 240752 18746 18803 234779 170643 18753 18760 59079 23939 26419 26395 93742 140721 15170 19248 19262 110157 19697 53378 230126 22042 22323 22324 22325 22631 108705 640703 72828 227937 208650 11502 54126 19134 68481 13449 13549 26431 12534 105787 108079 20112 13649 13685 14360 606496 16451 13866 12568 20399 18127 12566 15461 18750 16452 12703 14786 20111 58194 16590 56717 20850 20851 13712 19253 30955 12371 26406 666899 16396 26420 73086 14388 54401 13867 12015 19353 12821 109620 13844 192897 11848 17126 17127 17295 18810 22352 74769 18707 18710 384783 16480 226970 12550 18752 13016 54721 229615 15382 26407 12702 105782 54473 53859 12043 20844 100040260 12606 17979 319152 11820 12558 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 14251 74326 236576 24063 24064 57783 21787 67938 108100 24105 70527 12631 20499 229709 107971 327826 19765 20867 399510 56460 69710 232910 12757 73379 19261 71544 12988 216810 13014 12388 218518 74256 11771 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 11657 11674 240753 13855 229285 26936 98432 224650 23943 209039 22378 80794 14302 78757 235406 228136 104831 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 26934 11740 227753 13854 16952 15194 11746 215114 628438 11804 16332 16337 16400 16412 11836 67859 11843 16653 110308 16687 110310 16691 16667 16668 11855 16835 210126 109904 17709 17886 17920 17999 23980 50932 ID%NETPATH%ID ID 15205 18507 19185 19650 66313 26396 21423 11910 12566 19651 17127 21416 13712 26413 26395 26417 19645 13714 13713 14200 110157 15903 17877 IL9%NETPATH%IL9 IL9 26413 54721 26417 20850 81601 16199 20851 20852 IL3%NETPATH%IL3 IL3 56637 17096 20416 14694 14388 14389 12125 12048 14461 20181 56461 54401 19401 12929 20525 216233 18033 12015 606496 13448 56458 22631 18709 18747 12984 14083 14159 18708 15461 18750 12912 12702 18751 26413 18707 26395 19052 15170 12928 16331 19264 100040260 IL5%NETPATH%IL5 IL5 56637 53378 26396 20850 17096 20416 14694 20851 20662 20846 12929 26416 20963 18783 18033 12387 13712 11689 18035 16191 16185 16192 13430 606496 20677 15163 16451 22631 30955 19229 12028 12402 20848 15461 18753 15162 56484 14784 107746 12703 16476 20111 22248 19247 11909 110157 IL4%NETPATH%IL4 IL4 17979 319152 18033 18035 12015 15077 320129 56463 16189 16451 16163 16164 20375 12767 16186 234779 11651 14083 18753 328572 16452 26419 12703 19094 18707 384783 15170 19247 11909 12608 218397 12675 23871 20416 18706 12914 26416 20963 13712 54721 21939 12402 20848 26413 26417 16150 16331 20844 12606 IL-7%NETPATH%IL-7 IL-7 56637 26396 20850 20416 20851 20846 12015 14360 606496 16367 56458 16186 16196 208650 11651 20848 18708 56484 26413 26417 26395 384783 16197 16453 20844 NOTCH%NETPATH%NOTCH Notch 15205 11820 21423 18033 15182 13389 14357 14199 56381 59287 20466 19664 16450 16848 11651 17127 17305 18129 18708 18132 18133 18550 50754 328572 100039623 16452 54485 55927 433586 100042305 19165 19763 27401 17125 22632 16842 208117 270118 60406 66935 21402 20185 20602 26965 103806 18519 56438 19697 56637 20779 20848 26413 26417 IL2%NETPATH%IL2 IL2 26396 15519 17096 14389 18033 13685 16185 14360 13684 667739 16367 16451 16186 12566 11651 18708 12912 56484 26419 74769 16476 18707 26395 18710 384783 15170 19247 11909 56717 12928 64685 56324 110157 16432 23872 18795 19697 14815 16183 16184 16168 230126 23871 22608 20850 20416 18762 20849 20851 18706 21752 20662 22349 17346 27979 12929 26416 12447 13712 22324 18709 30955 19229 12402 20393 12702 14784 26413 26417 12043 16453 20844 16818 TSLP%NETPATH%TSLP TSLP 26420 19697 20850 11651 20848 20849 20851 20852 20846 18034 19698 26416 18033 18035 26413 26419 26395 26417 13684 RANKL%NETPATH%RANKL RANKL 19696 22034 12675 14083 18034 18383 26416 11973 83433 18033 22029 26419 22030 22033 22031 21943 18412 17342 26409 20375 66513 68652 IL1%NETPATH%IL1 IL1 67857 26420 26397 19697 26399 19696 22034 230233 12675 26416 18783 18033 18035 73914 13448 16175 16176 16177 16181 16179 108960 17874 18709 266632 30839 93834 67245 667310 93765 66589 16178 11651 18708 26413 26419 16476 26417 19645 11909 16150 54473 53859 26405 66513 68652 66724 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 216136 12035 12036 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 110208 21351 21881 14751 15277 15275 216019 19895 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 14073 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 22171 270685 13361 238505 17768 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 14430 11676 15277 15275 11674 16548 216019 230163 74246 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 17260 26398 13684 17261 102626 26416 100040260 22034 17164 29857 15507 19094 269881 26415 26399 13712 56613 13631 73086 17346 16177 66513 26407 26409 68652 17347 20807 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 102626 26416 17164 15507 26413 27371 26417 22339 18710 110157 20698 75292 101540 21804 18127 216148 15251 19303 11836 109270 18704 240752 18751 107321 18783 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18708 18709 16542 18803 234779 18706 18750 74769 19353 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 170758 11651 14083 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 16188 16185 20728 16184 17869 16453 83430 384783 16165 16164 17164 67071 16196 16195 16194 16193 12576 16192 13712 16169 12675 16191 12575 17346 16168 16190 16189 332110 11652 110651 17347 20807 26413 26417 110157 18127 11836 18706 74769 18176 109880 11651 20111 50772 56484 23939 16150 20416 56717 18607 16367 16183 20846 20662 20848 12765 13714 227288 56637 23797 20663 237313 20847 16173 20849 60505 16198 13713 20375 16175 14281 16163 16162 16161 20851 100042555 16156 20850 16155 20852 16154 16153 77799 20112 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 54391 319945 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 12892 237926 97541 17025 22275 14151 107508 19044 67417 15288 70383 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 269587 209195 19049 210044 12288 14677 14702 16527 223604 14688 214084 18747 12291 11440 108015 108043 11444 110835 11438 110834 13491 13489 19045 192176 13822 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 17855 20775 68603 14593 56075 110196 14137 16987 192156 100040592 15357 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 68159 242607 108069 108068 243961 20513 22318 74732 53623 14800 14799 110637 140919 14814 58234 14813 20511 14812 20510 14811 14810 20512 216227 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 103711 107272 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 12444 12445 67236 12447 68240 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 19645 18705 20437 18706 11920 12566 74769 19650 18707 26416 18176 29857 19094 26415 12575 11651 11652 18607 18710 23797 18704 240752 225326 12447 15461 22059 320207 22061 12387 22062 19211 19052 19053 30955 234129 18708 16653 18709 12450 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 208967 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 268860 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 15465 16440 14701 16439 14675 18798 18799 18802 14682 74055 16438 114875 14672 14702 18751 14688 18762 18761 18753 18754 18752 18755 18759 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 14672 18749 108071 14816 14814 66168 26556 14813 19108 14812 19084 19085 14811 14810 14809 18751 18747 14805 18798 14682 16438 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 20846 17260 26398 17869 26416 17187 13198 29857 26419 26397 19094 22166 26420 26415 12043 26399 13712 18783 16476 13631 17346 17347 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 18749 19108 210044 14677 14702 16527 223604 14688 14678 18747 66066 11513 15557 19088 19087 15552 15551 15550 14681 14679 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 14702 18751 14688 18762 18761 18753 18754 18752 18755 18759 18430 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 14695 14693 11513 14709 14701 15562 14680 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 242425 16519 12286 54393 12287 224129 11512 11514 11515 432530 104110 14710 14708 14706 14704 14696 14695 14693 14709 18749 19084 19085 210044 14677 14688 18747 66066 12291 11513 19088 19087 14681 14679 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 56791 216080 22210 100041484 66105 100041766 68612 218793 22194 67196 620934 56459 50995 74153 22201 22193 22209 74244 53323 22195 93765 70620 22200 100039535 231380 22213 67128 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 13869 22408 57265 22419 12560 228357 93897 21416 22412 216795 66713 80890 22410 22414 22411 13542 19664 55992 58235 21415 22409 217127 12550 13544 13543 78943 238880 11459 22417 19668 94217 225372 16480 12505 11787 26946 16842 18128 11461 18129 18131 18132 56175 19164 19165 11820 100042305 56637 208117 23821 59287 81601 22063 22067 22066 16971 14725 22068 93735 17356 14367 14365 11464 11465 11475 14314 12387 16974 22415 14362 16973 22413 22416 14366 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 56847 56752 14204 11671 110695 11668 11669 212647 11670 72535 17161 107747 109731 216188 19378 237320 69748 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 22059 22061 26374 22062 17246 17248 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 216136 12035 12036 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 68738 60525 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 68087 211347 106564 269614 74450 75735 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 11428 64602 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 26416 29857 19094 26415 12675 16440 16439 26413 26417 16438 110157 11836 26419 26420 18751 16476 15461 18753 19354 30955 234779 18706 74769 19353 18707 26395 26396 18176 26414 57257 15170 17096 16150 22325 26405 19264 26406 22324 640703 20963 20662 18038 17060 12229 14784 12518 12478 15985 20663 12483 19055 19056 18035 14281 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 23797 13685 22084 19082 105787 64930 108079 19079 108097 18518 11651 22059 58988 22061 11652 22062 19052 19053 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 16956 239759 18796 85031 18797 269060 18795 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 29858 54128 110119 218138 69080 331026 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 22184 66585 70767 53607 20639 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 12914 19885 23797 56551 112407 112406 15251 11863 22346 22166 11651 11652 56717 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 29807 105663 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 12914 20021 66653 22130 74238 72308 21343 328572 71828 229906 235459 24074 83602 100043714 407786 74044 66420 19183 21374 227606 208677 26427 208647 78284 63856 228980 319944 14884 19084 68705 19085 98053 14894 68153 74197 69833 245841 237336 14885 209357 21341 108143 66464 19088 68776 19087 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 210044 14697 14710 14677 14700 14702 14708 14706 14688 14704 14696 14678 14695 14693 11513 14709 18386 14701 18976 14681 14679 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 13088 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 14583 14584 76355 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 11998 18429 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 14645 266744 14661 UNTITLED%PANTHER PATHWAY%P00019 untitled 18796 18797 18795 16440 16439 14675 11652 18798 26413 14682 26417 16438 14672 18749 110157 18127 19084 19085 210044 11836 18751 18783 18747 18762 11513 18761 19088 18753 19087 18754 18752 18755 18759 14680 104111 19091 18750 54195 224129 60596 11512 19092 11514 13617 26395 11515 13616 26396 13615 432530 13614 104110 271639 13618 234889 11651 23797 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 15186 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 14287 22171 13361 14528 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 15560 14695 15559 14693 15558 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 14702 18751 14688 18762 66066 18761 18753 18754 18752 18755 18759 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 109905 223272 215449 286940 104303 228998 11858 140579 11840 12945 57342 16403 109700 16398 11845 14268 373864 53867 104099 381924 16407 16409 74194 11848 223881 217378 16400 11852 16401 11853 16402 16404 72065 192897 16419 74192 20130 238880 26408 19229 16408 12818 16421 16410 12816 16412 12927 12835 12834 12833 11461 57764 22323 67771 11867 56378 73368 14360 76709 16420 21894 12817 71302 12815 192176 12814 12813 16411 56443 16414 12821 107581 12819 140580 13196 12829 12828 20779 12827 12826 12825 26414 26405 26406 26398 26415 26407 26417 18710 110157 19303 11836 26419 18704 26397 240752 26420 225326 15461 19354 30955 18708 18709 18706 74769 19353 18707 26395 26396 18176 109880 12824 107746 14083 16399 16202 50772 12843 23928 330662 320910 20416 22330 12389 12929 76108 12928 74012 20662 12839 329941 12837 12832 12988 12831 16773 20663 94216 12830 16774 241226 60595 213119 225341 109711 11472 19248 16779 16780 226519 170736 11465 16772 16782 78514 12841 12840 16775 16776 16777 319480 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 17869 16453 67071 12675 332110 11652 110651 71302 218397 17973 18590 18591 18595 14390 76117 68797 19326 26414 71544 57257 14247 232441 18596 22325 259302 26405 71520 216445 17444 22324 69257 13709 17974 606496 94190 13710 14784 78177 75415 13876 13875 171207 11855 11856 320119 13711 56501 27049 30051 13661 56309 260298 22282 18080 58988 54153 320207 230233 16451 14389 114713 14388 20418 109333 16452 117600 17164 13712 56613 73086 17346 16440 26407 16439 17347 20807 26413 16438 26417 18710 110157 216148 11836 26419 16476 225326 15461 30955 18708 18709 18803 234779 18706 18750 74769 18707 26395 26396 18176 228359 109880 73167 23871 20111 50772 23939 16150 20416 18607 20846 20662 20848 13714 56637 20663 20847 20849 14281 20851 78514 20850 20852 20112 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 63993 20508 102857 667772 432516 17913 504186 54130 226977 17909 360013 11443 213603 110902 11435 17910 338367 71602 17918 17919 17920 17921 17922 270163 246177 17916 11449 208943 11448 11447 17912 244281 217198 231252 74376 667663 238880 17879 11459 544791 77579 17880 17882 17883 17884 17888 140781 17885 17886 71960 11461 329421 11440 108015 108043 11444 110835 11438 110834 11464 11465 11475 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 20846 20848 16453 20851 16451 20850 20852 20849 16452 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 192136 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 236539 100678 107272 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 18803 234779 18706 74769 19353 18707 18710 18704 240752 57764 22323 107449 69581 320207 18209 226251 18021 73181 22253 19354 18208 30955 18019 18708 80883 18709 13176 210801 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 229706 102680 214084 22598 381884 110877 13162 103098 20538 74338 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 13087 14262 21743 22236 394433 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 192136 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 238505 11720 232087 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 11853 667663 238880 17879 11459 544791 77579 17880 17882 17883 17884 17888 140781 17885 17886 71960 11461 329421 67771 11867 69581 56378 76709 19354 56443 19353 100042651 214230 107589 19877 18479 18481 68089 224105 22151 241656 22154 54004 18643 70584 18645 75477 213435 19878 22152 227613 22153 12632 12631 16765 228785 73178 67951 56471 73710 545486 13367 16885 11464 11465 11475 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 384783 26395 26396 67071 218397 13712 56613 73086 20111 110651 26413 16367 26417 20662 110157 20663 26397 16004 16370 14281 16002 16001 16000 58988 16334 16337 23920 20112 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 20846 15978 16451 15979 15980 16452 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 13195 21990 216343 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 68556 76654 18103 79059 56520 66757 331487 80914 22245 22271 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 53611 56216 20907 14697 12295 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 18749 108071 14816 19108 19084 19085 14677 14688 14678 18747 19088 19087 14679 12286 12287 271639 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 242607 20513 22318 53623 14800 14799 110637 14814 14813 20511 14812 20510 14811 14810 20512 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 26398 100040260 11798 12018 228355 12675 19697 19698 13804 26926 12028 13665 26400 11652 11910 11911 223922 26413 19696 71609 26417 14082 23992 21926 14939 225028 16994 53859 26408 12125 14102 14103 12048 19106 11783 26419 16992 26397 12367 12124 26420 13163 18751 12043 26401 66593 16476 21937 21938 22035 226641 18761 26412 18753 14943 18754 18752 81703 18755 12369 12370 12915 30955 11909 19766 11797 670717 12905 22030 18706 18033 18750 18034 74769 26921 21933 18707 11796 12371 11651 26414 16150 23797 18035 16004 14281 22059 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 12035 12036 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 26398 102626 26416 17164 67071 29857 19094 26415 26399 13712 11848 26407 26400 110651 11852 20807 26413 11853 26417 110157 11836 26419 26397 26420 26401 16476 225326 15461 19354 30955 11909 18706 74769 19353 18707 18805 26395 18806 26396 56044 64143 18176 19731 66482 19730 109880 21844 23871 170758 18479 11651 18481 20111 26414 224105 20416 18607 20846 20662 20848 606496 14784 56637 23797 20663 16653 20112 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 18750 18796 26395 18797 26396 18795 14697 14710 14700 14708 14706 110355 14704 320129 14696 13712 13653 14695 11606 14693 11607 14709 109689 216869 16440 16439 26413 14682 26417 16438 110157 14688 66066 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 20021 66653 22130 74238 72308 21343 71828 229906 235459 24074 83602 407786 63856 228980 319944 14884 68705 98053 14894 68153 74197 69833 245841 237336 14885 209357 21341 108143 66464 68776 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 22030 18706 11920 12566 12914 17246 17248 328572 12575 11651 20610 100043429 29870 17873 11652 13197 18519 22427 433759 18607 20466 23882 12532 23942 50883 18854 100043858 93759 12578 23797 55948 12534 434174 12447 22059 22061 22062 19211 234129 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 18796 18797 18795 14697 12295 14710 14700 14708 14706 12290 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 14702 18751 14688 18762 18761 18753 18754 18752 18755 18759 18803 234779 12286 18750 12287 20614 22320 20619 67474 22319 22317 22318 12296 20908 22044 22045 22094 12640 12297 12298 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 20652 15486 15487 16889 15485 27400 13075 223920 15490 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 66713 22410 22414 22411 21415 22409 12550 238880 11459 22417 16842 11461 12387 75599 93701 93706 54216 19246 233651 93893 93889 270120 93886 93891 18526 93887 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 93873 353237 353236 73173 192164 353235 170677 12939 12937 12941 18163 12388 12936 192163 353234 93881 116731 12558 23836 279653 245578 215654 320873 12565 12564 241201 12563 93872 12562 93724 12561 12552 268663 18530 211712 245827 14107 12557 12556 12555 12554 22295 219257 239096 11994 14158 104010 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 93735 14367 14365 11464 11465 11475 14314 22415 14362 22413 22416 14366 UNTITLED%PANTHER PATHWAY%P06664 untitled 19697 20482 21815 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 76507 237940 11754 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 17449 18598 66052 12974 14194 18293 18604 56451 11429 18597 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 11947 11949 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 242669 18263 54375 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 66904 17850 52665 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 79464 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 103149 104776 22240 12934 64705 268860 23959 72269 99586 65254 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 66646 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 18749 19108 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 18747 14695 14693 11513 14709 11554 19088 14701 19087 14680 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 606496 18706 56637 384783 17246 17248 22084 64930 16004 16370 16002 16001 16000 16334 16337 23920 56458 56484 19211 234129 18607 16367 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 18749 19108 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 18747 14695 14693 11513 14709 19088 14701 19087 15466 14680 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 14695 14693 11513 14709 14701 11556 14680 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 14544 11717 23959 22436 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 238505 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 14672 14697 14710 14700 14702 14708 14706 14688 14704 14696 14695 14693 14709 14701 18976 14675 12922 14682 12921 14680 12918 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 225724 319924 11784 12289 18750 54652 12292 74764 26416 57267 320795 16594 263803 29857 12295 232943 16593 19094 11491 26415 26414 50772 332110 23939 26413 26417 100042305 208117 23821 59287 81601 12296 12288 26419 26420 18751 18762 56175 18761 19164 18753 19165 18754 11820 18752 18755 18759 109333 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 12411 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 19353 12767 19876 57764 20563 11350 20564 20562 20315 18209 19354 18208 11853 80883 13176 117600 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 18103 79059 56520 114873 51797 227231 56749 69719 55936 18102 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 26398 26416 13869 29857 19094 26415 26399 26407 26400 11652 26413 208177 17532 26417 13649 210710 13867 110157 13866 69601 75292 236576 20130 101540 226525 26408 24066 24064 216148 18015 24063 66922 11836 23980 26419 73523 26397 18704 240752 26420 18751 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 18760 218397 109880 11651 26414 20416 26405 71520 26406 20846 20662 20848 23797 20663 20847 20849 320207 54153 20851 20850 14389 114713 20852 14388 20418 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 99571 14161 18791 18792 18793 18815 18787 17392 18788 18816 17386 83995 110135 17395 PNAT%PANTHER PATHWAY%P05912 PNAT 269587 13162 20614 22320 14706 20619 14704 67474 14696 22319 14695 22317 14693 14709 22318 18749 19108 209195 19049 210044 20908 14677 16527 223604 14688 214084 14678 18747 66066 11513 19088 19087 19047 13491 13492 14679 13489 13488 19045 14687 192176 13823 13822 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 103583 24069 20423 12234 269209 12914 14634 19206 14632 319757 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 63993 20508 16519 102857 14686 16521 14697 16522 271639 14710 16524 14700 14685 14708 12672 14706 243764 14704 14696 14695 14693 14709 18749 19108 19084 19085 14677 14688 14678 18747 66066 19088 19087 14681 14679 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 245847 67980 26384 74091 14583 14584 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 55994 21808 14573 238057 319618 14560 12914 11477 26416 11479 11480 11481 11482 29857 14106 14283 19094 75788 24087 26415 21892 14561 12153 20481 328572 66513 26409 26413 26417 20130 26419 26420 16476 15461 11909 18176 16477 20482 16478 26414 12154 16326 12163 12156 13590 110075 76793 12159 12160 12161 12162 12166 12167 23886 12168 14563 12155 17125 14562 17126 17127 17128 14566 17700 16325 12165 16324 18119 16323 110542 12705 320202 21809 21812 21813 17684 66313 242316 269275 17129 17130 17131 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 22371 21788 21824 16399 14060 58992 14724 14723 385643 14058 14071 14069 217847 66901 19123 54368 19128 14729 14062 19124 14065 14068 14066 16621 14061 99571 14161 18791 18792 18793 18815 110135 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 18706 74769 14686 14697 18176 14710 14696 14695 12371 14693 11651 56484 14675 11652 18607 14682 16367 18710 20662 14672 56637 23797 18127 20663 14699 14677 19216 54601 22631 14688 14678 58988 320207 16337 56458 14679 18708 18709 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 109905 215449 14823 108073 268934 210044 14677 14702 14688 18747 13491 13489 13492 13488 16521 16522 16524 12672 243764 108069 108068 640703 606496 12914 14710 14700 14708 14706 14704 14693 328572 14709 15465 14701 208677 18749 26427 208647 108071 78284 14816 19084 19085 14699 20605 20607 20606 15566 14678 15565 15563 11513 18682 15557 67300 19088 74325 19087 18386 12757 15552 14715 15551 20609 15550 20608 14765 14679 11539 11540 15562 11541 14680 18387 110078 16519 18389 104111 110095 19309 12671 224129 11542 11512 12669 11514 11550 11515 12913 432530 213788 104110 232493 14936 225192 17773 244701 18679 110094 15560 102093 15559 15558 99296 11552 11553 11548 11549 18390 12912 11555 68961 56637 11554 15466 11556 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 26398 26416 29857 19094 26415 26399 26407 26400 11652 26413 26417 110157 236576 26408 24066 24064 24063 11836 23980 26419 26397 18704 240752 26420 18751 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 218397 11651 26414 15170 20416 26405 14182 71520 53608 26406 14186 14183 14184 107971 20662 327826 23797 20663 54153 114713 20418 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 109900 18416 217214 11898 227231 69719 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 14697 14710 14700 14685 14708 14706 14704 14696 14693 14709 14701 640703 64337 212541 24013 225600 14699 12790 12788 70405 14702 30952 19674 20028 14688 19739 18587 18588 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 12035 12036 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 100226 12361 50873 53331 26443 67847 13162 26444 26416 19170 18806 18000 26440 19166 29857 19167 26441 26442 171469 72900 54401 13712 54204 14763 26414 332110 23939 26413 26417 55948 26419 22631 26420 12447 20617 19171 18951 18952 100039786 21823 26446 12448 22628 22627 19177 22629 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 63993 20508 18750 12671 12669 320795 263803 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 16440 16439 14675 18798 14682 16438 14672 14814 14813 14812 14811 14810 18751 14688 18762 66066 18761 18753 18754 18752 18755 18759 109333 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 210044 14697 14710 14677 14700 14702 14708 14706 14688 14704 14696 14678 14695 18610 14693 18619 11513 14709 18386 14701 14679 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 327762 15081 106344 18971 72151 18972 19075 19891 21973 21974 18538 19687 19718 18968 69263 319152 21969 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 73724 110821 66904 17850 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 18103 79059 56520 114873 18102 56248 171567 108147 100042069 11565 14923 11564 11566 20135 20133 231327 75533 382985 11636 11637 229949 635960 229363 14450 54369 68870 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 19401 14060 20181 22337 14473 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 109905 215449 18796 18797 18795 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 16440 14701 11848 16439 14675 217378 18798 14682 16438 14672 108071 14816 14699 14702 20605 18751 20607 14688 20606 18762 18761 67300 18753 18386 74325 18754 12757 18752 14715 18755 20609 18759 20608 14681 13491 13489 13492 11539 13488 11540 11541 18387 19395 18389 93690 12286 18750 233046 12061 12287 12671 12062 11542 99326 12669 19419 240168 110351 213788 16801 12672 243764 18390 108069 108068 64337 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 22418 22422 22421 22408 57265 22419 21416 22410 11848 22414 13542 11652 19664 11852 11853 22409 13544 13543 19668 18128 26401 18129 18132 18805 18806 20779 13449 13388 50915 11799 218397 14786 17973 13448 18590 14164 18591 16449 18595 13389 27261 13386 13837 12005 78390 13845 54635 18596 13844 270190 71520 21414 23805 232889 16450 17974 21687 11600 71785 54485 11789 13642 13641 16451 12387 26398 102626 26416 17164 15507 26413 27371 26417 22339 18710 110157 20698 75292 14062 101540 21804 18127 216148 15251 19303 11836 109270 26419 18704 240752 18751 107321 18783 16476 18762 225326 15461 18761 18753 18754 18752 18755 18759 30955 18708 18709 16542 18803 234779 18706 18750 74769 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 18479 11651 18481 14083 224105 20416 14182 12929 12928 20846 107971 20662 327826 20848 56637 23797 20663 14281 14367 14365 14362 22413 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 20135 20133 18103 79059 56520 382985 66757 114873 22171 21915 110074 18102 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 56216 70450 20907 19339 22249 20910 20614 20979 229521 54524 171180 53420 22317 13852 208898 54525 319508 20981 20980 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 54401 11848 12028 110651 12550 53859 19229 12048 16410 16412 14702 12367 12927 18792 14688 214084 18747 17392 11909 20779 13653 216869 26414 17096 640703 14784 19055 18035 13685 12387 252972 20613 19247 26403 14919 667739 16452 18125 233979 12759 17260 12424 26398 12426 13684 110596 17261 22026 15568 26416 12326 21413 22034 20192 20191 11640 15507 20190 23938 67605 20687 26399 12494 13712 56233 20683 22612 19225 19016 15937 12015 14459 15200 20807 26413 16438 26417 18749 110157 101540 19303 11836 26419 18751 26420 12043 18783 16476 18761 18753 18754 18755 18019 18708 18803 18750 19091 74769 19353 26395 26396 432530 18760 109880 19877 18479 11651 14083 20111 56484 23939 12912 20416 18607 16367 12928 20662 20848 13714 18263 56637 14281 56458 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 12183 18746 18655 21991 18641 216019 14751 15277 15275 18642 56012 11674 13806 13807 100043349 18770 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 16450 54485 18222 66935 103806 19668 20602 18128 18129 18131 16449 18132 13389 13386 19664 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 268860 14417 14415 246277 214579 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 26398 12371 26414 14082 26408 14102 14103 11783 26419 16907 12367 13368 20259 26420 13163 14084 12368 16476 235587 11546 16905 16906 11545 328417 12332 12633 12369 227753 12370 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 12361 12767 12675 19697 19698 11848 11652 11853 74192 20130 238880 11459 19229 16408 12818 16421 210044 12816 14677 16412 14702 12835 12834 12833 11461 18747 67771 11867 56378 73368 76709 56443 18034 16477 16478 71520 22324 16452 16653 18796 18797 18795 14700 14708 14706 14704 14695 22371 14709 16440 14701 16439 14675 18798 18799 18802 14682 26413 74055 16438 26417 114875 14672 18749 110157 667663 17879 544791 77579 19108 17880 17882 17883 17884 11836 17888 140781 17885 17886 18751 71960 329421 16476 14678 18762 18754 18021 73181 14681 56212 19354 14679 30955 13051 18019 12769 18018 56744 18803 54199 234779 14294 18706 14293 12273 74769 15975 224129 54446 19353 18707 11512 15945 20303 20304 20306 20296 18176 20292 277360 57260 20293 23832 20302 214230 12777 107589 20297 19877 100038965 18479 12772 11651 18481 20299 12768 68089 224105 12766 12145 80901 241656 16150 20312 20416 12776 12775 18607 12458 70584 12774 16183 12773 12771 213435 20662 12322 20848 108058 12765 227288 23797 228785 11464 11465 11475 15978 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 18950 15452 14544 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 13424 66445 11771 26398 11772 234663 12337 12914 545156 15194 14447 68097 268958 20430 12339 23830 269881 12064 20683 328572 66713 26400 100043349 21374 74192 238880 11459 228980 11783 12367 26420 11461 16476 67771 11867 74325 12370 56212 19354 56443 19353 14809 100042651 14807 14806 14805 22151 22154 110637 22152 227613 14814 22153 56455 381917 14813 110350 215114 14812 432611 13385 14811 67951 15114 14810 235661 73710 13191 545486 73647 69543 104215 110082 14281 12333 12334 12335 12336 22059 11464 12338 11465 13417 22061 11475 54152 22062 29816 13427 13426 73916 100042162 80837 76884 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 94041 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 69634 18534 18746 18598 18563 104112 17436 12974 18770 18597 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 12675 19057 16797 12500 12501 12502 11652 12503 16822 22637 26413 16818 12487 26417 12519 16438 12524 18710 110157 11836 26419 26420 26401 16476 225326 15461 18761 30955 18708 18709 18803 18706 74769 19353 18707 26395 26396 18176 109880 17973 18479 11651 18481 224105 57257 16150 22325 19264 17444 22324 640703 20662 17974 23797 20663 19055 19056 18035 14281 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 26416 26395 26396 22034 13712 12675 66513 26409 16150 26417 21353 16179 21899 21898 142980 225471 24088 26410 56480 26940 170744 18035 26419 266632 26397 81897 17874 26420 56489 117149 18037 16476 54131 106759 54473 170743 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 216134 103711 107272 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 19057 14702 14688 67155 93761 20586 20585 20439 20588 20587 13001 13000 73016 103583 21372 70425 103236 12234 27373 104318 93687 140577 75560 12385 12386 68058 93762 216033 54380 59036 77578 20215 68094 83796 83797 57376 66993 68142 100043597 226849 225849 26931 21770 26932 84035 19058 19059 114606 170735 70315 81004 18099 93760 17125 15183 21885 21886 54366 17128 21888 21887 68911 15182 15201 72135 12387 19052 19053 17129 20437 18796 18797 18795 14700 14708 14706 14704 14696 14695 14693 14709 16440 14701 16439 14675 18798 14682 16438 14672 18021 73181 18019 64337 93735 14367 14365 14314 16974 22415 14362 16973 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 22410 22414 22411 13542 21415 22409 12550 13544 13543 22417 16842 109689 216869 12005 433759 19055 19056 75599 93701 93706 54216 233651 93893 93889 270120 93886 93891 12914 18526 93887 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 328572 93873 353237 353236 73173 192164 353235 170677 12939 12937 12941 12936 192163 353234 93881 116731 12558 23836 279653 245578 215654 320873 12565 12564 241201 12563 18751 93872 12562 93724 18762 12561 12552 268663 18761 18530 18753 211712 18754 245827 18752 14107 18755 12557 18759 12556 12555 12554 22295 219257 18018 239096 11994 104010 18750 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 56637 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 11486 11821 18950 15452 22436 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 15450 16890 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 12286 12287 56216 14686 20907 14697 12295 271639 14710 14700 20614 14708 22320 14706 12290 20619 14704 67474 14696 22319 14695 22317 14693 14709 108069 108068 22318 18749 19108 19084 19085 14677 14688 14678 18747 66066 19088 19087 14681 14679 UNTITLED%PANTHER PATHWAY%P05916 untitled 18387 210044 14697 14710 14677 14700 14702 14708 14706 14688 14704 14696 14678 14695 18610 14693 11513 14709 14701 14681 14679 11998 18429 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 19353 16801 65254 12934 64705 18479 20354 14302 11848 18186 14360 18844 235611 26757 20346 19354 14159 12568 12933 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 12286 108071 12287 14816 18796 18797 18795 14710 14677 14708 14706 14688 14704 14696 14695 12291 66066 14693 14709 14681 14679 12801 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 21340 227606 21339 21429 17749 20018 63856 19285 106298 20017 22130 237336 21341 19183 21374 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway 216134 103711 SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 66757 21877 72269 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 18749 19108 210044 14697 14710 14700 14702 14708 14706 14688 14704 14696 18747 14695 14693 11513 14709 19088 14701 19087 11555 14680 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 14697 14710 14700 14708 14706 14704 14696 14695 18610 14693 18619 14709 14701 18390 12912 18749 19108 210044 14677 14702 14688 14678 18747 11513 19088 18386 19087 14681 14679 14680 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 27053 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 14672 18750 18796 18797 18795 11551 11552 11553 11548 18753 11549 18754 18752 18798 74055 16438 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome 110391 20751 13361 11677 12408 19286 320415 14528 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway 100038824 11606 11421 ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway 16542 THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate 55951 269951 112407 112406 66945 18563 67834 27376 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway 15452 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway 14815 15519 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway 21939 21947 12675 230233 26416 26401 22034 18033 18035 16151 16150 22031 19252 21929 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism 224020 228550 83493 56717 56208 18711 16329 71780 55980 66461 74769 56727 234729 269180 75669 69718 18798 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway 100038824 11606 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism 110006 223337 70974 14936 72157 11722 77559 14387 216558 22235 110095 14751 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway 11670 107141 11668 14863 13114 13088 13087 72303 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 98314 216456 269951 66945 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 14661 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency 110006 22239 15275 14751 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway 18750 18803 18751 20963 19353 16818 14784 16797 20416 26419 14281 110157 13712 15461 16476 26401 18708 26400 18033 14360 18035 26395 12313 19055 19697 26417 320139 19419 54446 22190 12502 12503 19056 12500 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway 26357 18984 624814 18671 17250 22436 105349 19765 18104 75406 18127 58810 109857 12780 12408 70840 226646 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling 27053 11833 104174 14661 15109 13382 216456 227231 231691 66514 434437 14645 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 18750 18795 18751 12289 54652 12292 26413 110157 15461 12288 18033 18035 26395 16438 19697 26417 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway 20927 16334 12286 20526 56808 12295 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor 18750 18795 16438 14682 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism 18718 224020 103199 18795 16331 13649 56208 52858 18711 18704 225326 13866 18707 18720 228361 234515 234729 75669 18708 19211 64436 104015 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis 671878 18263 232087 20810 108645 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism 100038824 11606 11421 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation 14651 109801 52815 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway 63959 434203 13178 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 13077 58226 394433 11928 71853 18747 69191 16521 12846 67838 98660 394434 16535 12304 12291 394436 16493 19035 330953 64136 16523 12282 20927 67397 16514 14828 20271 22004 13849 16519 94284 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 107141 13114 18104 13383 16511 20191 20928 246133 13106 232975 19084 20649 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) 110446 15107 11409 15108 52538 93747 11363 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine 20115 319195 67248 100043391 97541 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway 224814 76408 12575 12780 18671 17250 545486 19765 22143 22059 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease 16922 11671 26874 11666 26458 56794 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway 100038824 11606 11421 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis 22173 13190 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway 13114 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway 100038824 11606 11421 INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 14701 14688 14309 12640 210044 18749 19045 12912 14699 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency 21823 18948 13195 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism 117147 107146 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle 11826 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism 55980 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) 110911 66586 52123 66461 14732 74451 14555 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway 20517 12780 13114 13088 56448 394434 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms 12753 18160 18626 27373 12952 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway 18750 18803 18751 20963 19353 17060 16818 14784 17096 15985 20416 109305 26419 14281 110157 13712 15461 16476 26401 26395 12313 19055 26417 54446 19056 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins 14688 22141 18795 12669 15560 14699 14682 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine 20115 319195 67248 23874 66590 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway 100038824 11606 11421 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway 13077 13114 13087 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 94284 20859 14871 27416 239273 231396 20860 20887 26357 56448 18671 17250 13106 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation 12039 12040 66904 110821 13171 13382 231691 17850 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway 71519 14775 208285 17001 19223 13850 13114 100040843 13088 13110 16993 11684 394434 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 56448 12408 72303 14598 13106 72054 66469 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 234734 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway 224814 76408 12575 12780 18671 17250 545486 19765 22143 22059 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain 66043 11950 14571 17708 66945 11947 670717 100039108 66925 11949 22273 54405 100043349 11739 14385 17705 11946 67680 66052 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism 56316 18104 27973 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway 20266 20264 13077 13114 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism 69019 110948 100705 26363 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway 100038824 11606 11421 OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism 11677 72157 74246 14430 226413 216558 12091 14387 11605 15275 14377 14595 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway 11670 13114 13106 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism 228550 71780 55980 234515 217837 75678 269180 23827 17330 56409 27399 170835 69718 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism 110446 15107 11409 93747 15356 117147 67041 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway 110446 68603 100040592 319554 14137 16987 192156 15357 17855 110196 20775 BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I 18746 21991 100043349 56421 14751 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis 18777 12660 14571 13026 192654 19210 52858 12647 56209 13139 18618 66461 14732 74451 14555 66586 19012 320951 18782 237928 74596 18806 55979 27388 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway 11537 109828 230558 12279 15139 14962 18636 12266 12274 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway 107141 13114 56448 15567 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism 11605 268656 14466 22239 18605 22234 20773 67630 53418 56632 230379 242285 223753 70059 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) 110391 20751 13361 11677 12408 19286 320415 14528 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides 20656 667310 12359 22178 20657 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway 100038824 11606 11421 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect 69719 55951 13806 104112 66945 67834 64602 66925 18663 20501 20916 12183 14194 15275 18293 27402 15926 11428 15929 14751 14447 17449 18746 67680 239606 66052 12974 18642 12040 19895 14661 14782 14660 100198 21351 110208 83553 11676 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway 13114 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway 224814 76408 12575 12780 13114 18671 17250 545486 19765 22143 22059 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway 18750 18803 16337 20851 26413 16367 16334 15170 12703 20528 14784 14600 20111 20416 20662 20850 16452 110157 15461 26395 26417 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct 20276 11931 11932 20277 11933 11928 98660 11827 110935 27411 20533 100038824 11828 12346 20278 232975 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle 14571 100043349 14555 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia 110391 20751 13361 11677 12408 19286 320415 14528 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism 225326 18707 74055 66461 101490 234729 75669 16332 218441 277360 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine 20115 22321 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) 13163 12368 19090 16905 16906 14082 12633 26409 18479 11545 11857 12370 12367 13347 19645 26419 12369 26398 19249 224105 16907 26401 16476 13368 14102 20740 14103 192656 14084 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I 76282 11611 55951 18563 224805 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle 19895 21991 66646 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway 13867 18750 11491 19164 100042150 13869 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway 100038824 11606 11421 FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway 71519 14775 208285 17001 107141 19223 13850 13114 100040843 13088 13110 71853 16993 69191 11684 67838 106648 394434 105349 12304 64292 394436 19215 19035 11689 64136 11686 12282 21391 67397 11687 14828 11688 19224 19225 18399 22236 19879 12408 71773 72303 14598 13106 72054 66469 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule 30962 20532 54403 20544 11826 69354 50934 18399 20510 12346 102680 20518 20540 330836 17254 20539 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway 18803 13856 13857 15170 14784 20416 20662 26419 20850 14281 16452 110157 13712 15461 16476 26395 26417 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway 13114 56448 18390 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway 11421 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway 14381 18641 19895 72157 66646 230163 21881 232449 19139 66171 14751 14121 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development 18091 14463 20807 74318 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency 14415 268860 104776 11669 64705 99586 11754 103149 338403 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell 14688 56508 18750 22318 18795 16440 19339 55984 14652 271639 12286 20526 20927 14702 56808 14682 12671 12295 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 14688 18749 19045 12912 14699 15565 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway 107141 13114 13088 56448 72303 18390 13113 14811 14810 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism 107869 216443 232087 20768 23971 269378 67547 67011 14598 12411 50880 108645 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 14688 19214 210044 18749 14699 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism 66681 14376 14936 216019 15275 74185 14751 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling 14688 18795 11651 19877 432530 78134 20807 16438 14702 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism 29807 105663 116914 66566 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 ARGININEMIA%PATHWHIZ%PW000183 Argininemia 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 18750 18795 110157 18751 15461 18033 18035 26413 26395 16438 19697 26417 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway 11670 12359 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 68738 60525 72535 11669 13106 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 18750 18803 26413 20851 16334 16367 15170 20528 14784 14600 20111 20416 20850 16452 110157 15461 14599 26395 26417 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism 76282 11611 55951 18563 224805 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III 72157 74246 67883 14430 216558 22235 103988 14635 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway 18750 18795 18803 11651 22324 30955 104709 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging 192185 19017 226518 93759 12753 59027 18160 66454 18104 74080 19883 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 14688 18749 15566 19045 12912 14699 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway 14815 15519 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway 107141 22236 19879 13114 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 19224 19225 71773 18399 72303 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis 18746 18648 21991 15275 100043349 13806 56012 319625 20525 56421 14751 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway 107141 20538 13077 13114 56448 15567 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 100040287 16520 19088 11554 215999 16518 67821 12288 19085 20541 19087 20650 56543 16525 16509 56808 12295 18749 20544 13383 16511 20191 20928 246133 232975 19084 20649 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13077 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway 14262 394433 13088 13087 11761 11444 110834 11438 394434 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis 20425 56752 170442 73251 192289 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway 11636 18103 18102 11637 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism 107869 14630 14718 14629 12583 83429 27267 246221 16828 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway 18750 18803 13649 18751 14784 20416 26419 14281 26398 110157 13712 15461 26401 16476 26395 26417 20807 20847 20846 20848 16451 100039026 13645 20662 218397 20852 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) 107869 12411 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism 57028 216134 11647 103711 11761 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism 72157 74246 67883 69976 14430 216558 22235 15275 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway 100038824 11606 11421 PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 216443 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway 434203 104158 72269 72962 22171 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism 18605 22173 54391 319945 11431 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 71853 69191 67838 98660 394434 12304 394436 19035 64136 12282 67397 14828 231396 56808 12295 22236 12286 13162 71773 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 110446 15107 11409 15108 52538 93747 11363 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis 19012 14712 99712 228061 55979 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency 58250 54200 20887 23827 211389 23972 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway 100038824 11606 11421 CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway 15466 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway 19224 19225 13114 56448 394434 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway 11636 18103 18102 11637 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation 20537 11931 11932 58866 11933 11928 103988 98660 20526 232975 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway 109731 107141 17161 56448 15567 11761 13113 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle 76282 69354 55963 68267 14661 108682 20526 20528 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway 63959 434203 13178 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect 55951 100043349 216456 13806 56012 66171 18655 18770 16828 20514 66945 18563 67834 56451 66925 20501 209692 20917 11429 13382 14194 230163 235339 21881 20526 68263 15926 170718 11428 18597 14751 15929 78920 14381 17449 18641 18746 67680 66052 12974 19895 14661 15277 21351 110208 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway 11421 TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect 55951 18598 229699 20511 74419 100043349 216456 13806 18655 66945 67834 18563 56451 209692 20917 11429 14194 13382 235339 68263 170718 15926 56421 11428 14751 17449 14381 18746 67680 12974 14661 19895 15277 21351 110208 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) 66234 235293 18194 98386 13121 13360 15490 13595 74754 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway 56717 26413 54721 20848 16451 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway 104158 12038 436059 18390 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism 69718 56208 225326 71780 55980 66461 234729 242291 18706 104015 18798 12462 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway 670717 19353 19765 18706 11783 57257 11848 12675 12371 110157 56044 13712 54601 15461 11651 18805 19730 12048 17127 17128 26395 12015 26417 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis 14688 13070 11607 13079 15497 14702 14682 13072 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis 21823 18948 13195 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway 13649 26357 18671 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria 107869 14630 14718 14629 12583 83429 27267 246221 16828 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway 16416 16399 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway 11421 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling 14688 18795 11651 19877 432530 20807 16438 381810 14702 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway 11670 11668 13114 13088 13087 72303 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) 14652 227289 20494 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling 56458 384783 18607 16337 26413 16367 16334 20528 14784 20416 20662 26419 110157 15461 11651 26395 30955 104709 26396 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 107045 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism 69718 327655 71780 55980 242291 56409 27399 104015 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid 17449 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism 56208 18802 225326 55980 234729 75669 104015 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway 16416 16399 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway 70839 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System 210044 18749 13488 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action 20608 12346 15466 11944 11945 20604 14459 12426 12671 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway 107141 13849 13114 13088 72303 13113 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway 12043 12566 12534 12447 13555 17873 12443 18538 12028 11783 19645 12567 12575 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway 230558 12279 15139 14962 12266 12274 11537 12258 109828 625018 12259 12260 12262 667277 317677 12263 17195 17175 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway 19166 19167 26441 56424 26442 22194 23997 24108 19185 22201 26445 26446 19172 19173 19175 19177 67089 26443 26444 19170 19179 22190 19181 19182 23996 19184 26440 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway 18750 18795 18751 14784 26419 110157 13712 15461 60595 16476 26401 14714 18805 14715 26400 14672 17390 26395 224129 12322 12313 17387 14308 16866 13869 20779 11911 13653 12640 242274 12540 15200 26413 16438 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism 17960 13077 13114 13087 72303 22436 13106 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis 18746 15277 100043349 13806 56421 14751 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway 18750 18803 18751 20963 19353 17060 14784 17096 15985 109305 20416 26419 14281 110157 13712 15461 26401 16476 26395 19055 26417 19056 12229 12518 18021 73181 18018 18019 20662 19057 640703 22324 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling 14688 18795 14745 11651 19877 432530 20807 16438 14702 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism 110446 71911 15356 67041 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway 17523 13114 21973 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis 12660 13026 68671 18618 320951 99712 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism 224020 228550 83493 56208 16329 71780 228361 55980 66461 217837 56727 234729 75669 17330 18706 12462 18799 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis 12369 69719 21973 97165 434174 14939 13804 12367 13347 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway 16416 16399 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA 14688 18749 19088 14699 271639 18747 19085 19087 19084 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 85305 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway 14381 72157 19895 71336 74419 21351 66646 232449 56421 19139 14751 14121 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome 110006 22239 15275 14751 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway 230558 12279 15139 12266 12274 109828 625018 12259 12260 12262 667277 317677 12263 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis 12183 21991 100043349 14377 13806 230163 56012 319625 20526 14751 18746 18648 18642 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism 20322 15275 11674 18640 14121 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway 20927 16334 12286 20526 56808 12295 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism 110006 22239 15275 14751 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism 192185 67375 78914 226518 18113 225994 12182 59027 67993 76952 11761 18605 18950 18115 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway 11421 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism 20322 15275 18640 14751 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL 17869 56717 18671 14784 22059 20662 20850 16452 20517 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism 12359 107766 70560 56720 98256 71562 22375 21990 11298 70789 266645 13195 21743 13076 23923 15930 11669 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation 17436 104112 66945 66925 56421 17449 67680 66052 12675 12475 12974 117149 17087 21898 22034 13358 18033 17874 18035 16151 16150 19697 107476 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis 14701 14688 14309 210044 18749 14699 12000 COAGULATION%SMPDB%SMP0000586 Coagulation 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation 68738 12359 60525 72535 11669 13106 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 353172 27050 27370 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia 11677 72157 74246 14430 226413 216558 12091 14387 11605 15275 14377 14595 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) 66234 235293 18194 98386 13121 13360 15490 13595 74754 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) 192185 226518 93759 59027 66454 12494 71361 18104 74080 22059 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer 55951 216456 20540 209837 56309 16828 17436 269951 55963 104112 20514 66945 18563 14719 67834 56451 66925 20501 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 67680 66052 12974 14661 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis 19895 21991 66646 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle 11931 20495 11932 56365 11933 100038824 11928 98660 232975 107723 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway 11944 11945 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency 21823 18948 13195 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway 14688 19229 12927 18705 18803 20315 12767 14677 14699 26413 110157 15461 18033 18035 12928 26395 26417 19303 14682 14083 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway 11421 FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway 11607 100038824 11606 11421 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway 20266 11931 15550 11932 11549 107141 17161 109731 18549 11933 20264 11928 98660 13113 56808 12295 56448 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary 18642 14120 21991 15275 230163 11676 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 13077 13114 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia 76282 11611 55951 18563 224805 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling 19766 21353 12366 26397 12905 71609 22030 21926 26412 100040260 26399 26419 26398 12675 26416 26401 16476 18033 26400 18035 16151 16150 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation 16922 11671 26874 11666 26458 56794 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway 18750 18795 18803 11651 104709 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 15107 52538 93747 231086 97212 11363 14081 57279 12894 12896 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 76500 228550 71207 69718 327655 16329 71780 55980 269180 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis 18563 55951 12183 21991 100043349 14377 13806 230163 56012 319625 20526 67863 14751 14121 211347 18648 72157 18534 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13087 11928 394433 13088 98660 394434 110834 56808 12295 14262 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism 14317 11670 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 105148 27370 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle 14719 78830 17448 67863 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway 238505 108645 74129 110695 232087 14711 20425 12116 192166 218865 108037 68682 100434 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway 109828 625018 12263 230558 17195 12279 17175 15139 12266 12274 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis 14104 107476 CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway 434203 104158 72269 72962 22171 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine 20115 104458 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism 14415 268860 104776 11669 64705 99586 11754 103149 338403 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway 17523 13114 21973 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria 17449 17436 104112 55951 18563 68263 67863 18597 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway 107141 18979 70839 13077 13114 13088 18671 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway 20927 16334 12286 20526 56808 12295 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway 20648 11931 11932 11549 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) 15108 52538 93747 26922 231086 97212 19063 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells 18750 16331 18803 14125 16822 16163 16191 16189 16653 20963 19353 228026 18783 14784 18706 17096 18176 16797 12981 14127 57257 26419 14126 26398 110157 26416 15461 11651 18708 26400 14360 26395 26396 26397 26413 12229 21926 26399 20662 14389 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production 20608 12346 15466 11944 11945 20604 14459 12426 12671 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 216456 269951 66945 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 14661 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway 74419 66171 56421 14121 14751 14381 110639 19895 72157 71336 21351 66646 232449 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation 18127 18750 18795 12912 18033 26413 16151 16150 26417 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway 13649 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form 69019 110948 100705 26363 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway 11944 11945 NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism 71522 14415 211488 246277 12583 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway 238871 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway 13649 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway 70839 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation 19645 15469 27221 18049 15417 12226 14164 12227 12443 22059 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway 20927 16334 12286 20526 56808 12295 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium 63873 60613 226922 26946 60596 16536 110862 271639 54195 18127 234889 19091 19092 22065 22066 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway 107141 13077 13114 56448 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway 13178 13026 20887 18102 50773 26357 20519 212862 18671 17250 66588 76408 20517 12780 18655 68671 20518 239273 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway 107141 20538 13114 56448 15567 18671 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) 72157 74246 67883 14430 216558 22235 103988 14635 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway 72303 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway 11944 11945 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency 110006 22239 15275 14751 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification 18950 11832 64008 14873 57344 20528 20525 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation 14688 18795 18751 18033 16438 15465 14702 14682 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism 228550 327655 16329 71780 55980 234515 217837 17330 56409 27399 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20226 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling 14688 18795 11651 19877 432530 20807 16438 53978 14702 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway 20186 14170 83379 14186 14183 14184 20494 14182 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell 20648 20927 20271 14526 20650 12286 20526 56808 20649 12295 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 14688 210044 18749 19222 14699 17897 107589 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 26940 81897 53791 21899 66724 21897 170744 26409 26419 26398 12675 12475 117149 26416 17087 26401 21898 22034 18033 17874 18035 16151 16150 19697 54473 170743 16179 66513 142980 24088 68652 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis 18605 22361 71743 106564 75735 66812 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway 100038824 11606 11421 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 14688 18479 109905 11909 19094 18706 26407 18034 54126 109880 26419 11540 12675 223864 13712 56513 15461 76089 11651 26401 16476 18762 18033 26400 18035 16150 26396 18607 18749 12912 14699 26413 20111 26399 12015 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor 18750 18795 16438 14682 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria 15108 52538 93747 26922 231086 97212 19063 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 110960 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect 55951 100043349 13806 56012 18655 20512 18770 66945 67834 66925 56451 209692 20501 11429 14194 13382 235339 21881 68263 170718 15926 11428 78920 14751 14381 17449 18641 18746 67680 66052 12974 19895 14661 14660 15277 21351 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis 110391 20751 13361 11677 12408 19286 320415 14528 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism 72157 74246 67883 14430 216558 22235 103988 14635 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine 20115 319195 67248 100043391 100040331 432502 667279 668144 100043755 621100 665189 67281 666899 100042670 629957 100039316 76846 667739 234734 100038875 19921 100038991 267019 100043876 100043000 100043423 16785 100042986 20044 100040298 20088 100042740 56040 667618 57294 666669 100040970 20085 20084 19899 67891 66480 67097 19934 66481 67025 100039924 19941 100042823 14694 100039656 20055 672959 20054 666586 676253 67427 670211 100043527 27207 666487 68193 67186 19989 19951 76808 75617 20103 20102 20068 22121 65019 26961 27050 27370 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway 224814 76408 12575 12780 13114 18671 17250 545486 19765 22143 22059 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway 11421 CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway 20648 11931 11932 11549 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway 100038824 11606 11421 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism 69718 102954 16332 277360 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis 12850 71883 217707 52064 230027 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia 14317 11670 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway 107141 13114 238871 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 15107 52538 93747 231086 97212 117147 57279 11364 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism 58250 54200 20887 23827 211389 23972 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism 110115 15483 71853 69191 67838 12304 78925 208665 394436 15487 83702 19035 64136 13075 12282 67397 14828 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway 11670 107141 11668 14863 13114 13088 13087 72303 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate 55951 269951 112407 112406 66945 18563 67834 27376 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway 16542 22339 14254 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway 22236 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 71773 231396 18390 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13077 13114 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis 12660 19210 68671 320951 99712 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine 20115 319195 67248 107271 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism 224020 103199 228550 56208 18711 225326 16329 71780 55980 228361 66461 72469 56727 217837 75678 234729 269180 75669 17330 18706 69718 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis 71519 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway 15108 22236 231086 97212 13088 13087 66885 117147 74147 56357 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 226414 27050 27370 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance 20537 11931 11932 11933 11928 226413 98660 20526 232975 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway 100038824 11606 11421 METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 20648 20271 20650 20649 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway 224814 11668 13114 13088 56448 394434 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway 13867 18750 11491 19164 13649 100042150 13869 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway 18479 19353 76932 329251 12443 19765 18595 18538 12568 12631 57257 11461 12575 12445 17906 16885 12331 26401 18805 83767 107589 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism 13142 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation 107869 12411 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 22239 15275 14751 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway 55984 14082 26409 12675 26401 21898 22034 18033 17874 18035 16151 16150 19697 22190 19766 71609 21926 53859 16177 21937 21938 16179 17979 66513 16175 207565 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism 11461 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13114 11928 13088 98660 13113 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 72303 16508 18390 232975 14811 14810 13488 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect 55951 100043349 13806 56012 66171 18655 20514 67834 18563 56451 20501 20917 11429 13382 14194 18293 230163 20526 27402 68263 21881 170718 15926 18597 11428 78920 14751 15929 17449 14381 18641 18746 67680 66052 12974 14661 19895 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism 83603 68801 56473 76267 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism 238505 110695 232087 18618 12116 269378 218865 108645 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency 69019 110948 100705 26363 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway 100038824 11606 11421 ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine 20115 319195 67248 100043391 27267 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency 76282 11611 55951 18563 224805 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway 13649 FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway 100042069 104158 12780 13114 436059 26357 18671 394434 72303 23917 28253 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway 107141 18979 70839 13077 13114 13088 18671 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis 99439 224480 21819 114479 22018 13058 50490 13057 214593 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation 234730 75454 22122 75540 21991 230163 54128 76355 320844 14121 18641 20322 16548 11677 18639 110119 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 14688 18479 109905 11909 19094 18706 26407 18034 11541 54126 109880 26419 12675 223864 13712 56513 15461 76089 11651 26401 16476 18762 18033 26400 18035 16150 26396 210044 18607 18749 12912 14699 26413 20111 26399 12015 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell 20927 12286 20604 20526 56808 12295 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling 384783 56717 16337 16367 16334 64930 22084 13685 13684 11651 30955 104709 20539 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency 110446 71911 15356 67041 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling 15251 16176 21898 64384 216799 320452 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway 13114 394434 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway 11421 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 18387 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 14688 18749 19045 12912 14699 15562 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism 71853 69191 12846 67838 12304 394436 19035 15485 64136 12282 13076 67397 14828 20860 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway 13649 NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway 18750 18795 13649 18751 18747 14784 26419 110157 13712 26416 15461 60595 26401 16476 18805 14714 14715 14672 432530 26400 12288 17390 26395 26405 12322 17387 14308 16866 56808 20779 12295 11911 13653 12640 15200 12289 54652 12292 26397 26413 20662 16438 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway 22171 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism 228550 83493 56208 225326 71780 228361 55980 66461 217837 56727 75678 269180 234729 23827 75669 17330 12462 170835 69718 18799 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 26940 81897 26409 26419 14281 26398 12675 12475 117149 13712 26416 17087 26401 16476 21898 22034 18033 17874 18035 16151 19013 16150 19106 19697 26397 26399 54473 170743 16179 66513 142980 24088 68652 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis 110911 66586 52123 66461 14732 74451 14555 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway 18750 18803 18751 19353 16818 14784 18706 16797 20416 26419 26398 14281 110157 13712 15461 26401 16476 18708 18033 18035 14360 26395 19055 12501 19697 26417 22637 320139 19419 22190 12502 12503 19056 12500 18021 73181 18018 18019 20662 19057 640703 22324 30955 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway 63959 229363 13340 269346 22017 15452 11534 231327 11761 19353 23917 22436 27416 239273 114304 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway 12288 56808 12295 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway 18750 640703 18749 18125 11669 16438 22436 19055 14811 14810 13385 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect 55951 229699 74419 100043349 13806 56012 20525 66171 18655 66945 18563 67834 56451 66925 209692 20917 15275 14194 13382 235339 68263 15926 56421 18597 11428 78920 14751 14381 17449 18746 67680 66052 12974 19895 14661 14660 21351 110208 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia 57028 216134 11647 103711 11761 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome 18718 224020 103199 18795 16331 13649 56208 52858 18711 18704 225326 13866 18707 18720 228361 234515 234729 75669 18708 19211 64436 104015 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic 107869 14630 14718 14629 12583 83429 27267 246221 16828 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) 20186 28250 239273 227289 20494 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids 16922 26874 14081 57279 11666 11669 12908 56794 12896 72129 56273 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway 22171 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway 13114 13088 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 72303 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production 14688 17200 18749 14699 18976 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 22239 15275 14751 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway 11670 11668 13114 13088 13087 72303 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway 11944 11945 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway 18750 18749 18125 12313 19055 14811 14810 13385 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway 11863 11622 15519 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway 18750 18803 18751 20807 20848 14784 100039026 20416 13645 20850 26419 218397 16452 14281 110157 13712 15461 16476 26401 26400 26395 26417 13869 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling 14688 67168 11651 19877 432530 20807 14702 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease 110006 22239 15275 14751 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway 107141 13077 13114 56448 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway 13113 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation 18642 14120 21991 15275 230163 11676 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 15115 27050 27370 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway 20538 56448 15567 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin 14688 12640 210044 18749 19045 16867 12912 14699 16866 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation 20537 11931 11932 11933 11928 226413 98660 20526 232975 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation 18746 21991 100043349 56421 14751 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis 14245 13350 14732 55979 14555 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency 107869 12411 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway 11944 11945 VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia 14415 268860 104776 11669 64705 99586 11754 103149 338403 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation 237320 209692 13382 266645 78920 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 22375 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism 228550 327655 16329 71780 55980 234515 217837 75678 269180 17330 56409 27399 69718 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule 11931 11932 20497 11933 11928 194352 98660 11827 56365 100038824 11828 20541 11944 11945 232975 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway 11421 PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells 18750 16331 18803 14125 16163 16189 20963 16653 19353 17060 16818 14784 18176 17096 16797 12981 26419 14126 110157 15461 11651 18708 26400 14360 26395 26396 26413 21926 14389 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation 18750 18795 12912 84112 26413 19094 18127 12675 19224 18033 16151 16150 26417 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway 670717 18646 330914 11545 11855 11857 12370 12362 12367 11783 12371 16476 14939 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria 18642 14120 21991 15275 230163 11676 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 70223 65019 27050 27370 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine 14688 210044 18749 19045 12912 14699 15466 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling 14688 18795 11651 432530 16438 14702 65086 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate 269951 66945 55951 18563 67834 56451 66925 209692 20917 11429 216456 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) Statin pathway%WikiPathways_20260211%WP1%Mus musculus Statin pathway 16971 11814 11813 15450 11808 13350 16956 20778 18830 16835 11303 13122 15357 11806 20652 16816 17777 11812 11816 IL 9 signaling pathway%WikiPathways_20260211%WP10%Mus musculus IL 9 signaling pathway 20851 384783 12702 20848 26395 16451 16186 54721 26417 11651 20846 16367 18708 81601 16199 19247 16198 20850 14784 269523 26396 20416 16453 26413 Cholesterol biosynthesis%WikiPathways_20260211%WP103%Mus musculus Cholesterol biosynthesis 18194 110196 208715 66234 20775 319554 192156 13121 15357 13360 68603 235293 14137 16987 17855 Selenium metabolism selenoproteins%WikiPathways_20260211%WP108%Mus musculus Selenium metabolism selenoproteins 109815 107585 107869 223776 232223 214580 20342 80795 27361 13370 20687 19946 65967 14778 625249 50880 26462 69227 75420 71787 18986 20768 71984 75512 19697 14080 14281 28042 20363 13371 72657 20226 50493 20683 211006 109079 12916 14775 114679 20341 20364 280621 18024 14776 16476 18033 74777 TGF beta signaling pathway%WikiPathways_20260211%WP113%Mus musculus TGF beta signaling pathway 21814 24136 21803 55994 16451 26420 17125 12393 21815 20481 17128 12159 21926 14313 14225 20750 22408 21813 21825 16878 18121 16842 13805 17130 20482 94187 26417 12399 21812 18033 17127 68010 328572 18787 16323 268977 17126 20848 230597 15978 16476 17131 14106 15461 12387 14281 209446 13645 20846 12914 17129 16420 Hedgehog signaling pathway%WikiPathways_20260211%WP116%Mus musculus Hedgehog signaling pathway 14632 24069 13548 16147 14451 268697 19207 13363 12914 12534 14634 15245 19206 20423 16002 20481 19335 269209 319757 20220 14633 20466 Glucuronidation%WikiPathways_20260211%WP1241%Mus musculus Glucuronidation 216558 109785 226041 66681 15275 22235 72157 394433 613123 72094 71773 100727 394430 94215 394436 552899 22236 Non homologous end joining%WikiPathways_20260211%WP1242%Mus musculus Non homologous end joining 22596 14375 19090 17535 108138 75570 19360 75570 EBV LMP1 signaling%WikiPathways_20260211%WP1243%Mus musculus EBV LMP1 signaling 26406 18034 26419 21926 19697 67399 71609 15977 16150 22034 12675 26409 18033 16179 22029 20304 53859 12675 16151 20297 26413 15519 Estrogen signaling%WikiPathways_20260211%WP1244%Mus musculus Estrogen signaling 15182 26420 13871 24074 99730 20466 26413 17420 12443 229906 12043 69920 15183 13872 13982 12912 18706 328572 16150 20185 245841 231329 18747 20021 66464 12572 16476 14683 56233 12189 11651 74197 15185 102216272 108143 66420 14885 14884 14688 235459 68153 20779 15461 68705 16151 20022 20662 109880 26395 26416 18033 13712 216148 433759 21343 21374 17749 12914 76854 14281 69833 14784 16202 23894 226182 14699 67710 15184 70315 208727 209357 20020 66671 20683 12675 Transcriptional activation by Nfe2l2 in response to phytochemicals%WikiPathways_20260211%WP1245%Mus musculus Transcriptional activation by Nfe2l2 in response to phytochemicals 18750 26419 231872 12608 18024 50868 14629 15368 17132 13844 18706 14858 18104 14630 Methylation%WikiPathways_20260211%WP1247%Mus musculus Methylation 11720 232087 22017 18948 108645 140483 21743 18113 12846 Oxidative phosphorylation%WikiPathways_20260211%WP1248%Mus musculus Oxidative phosphorylation 75406 66043 228033 17992 595136 66218 227197 66091 11951 66916 68198 17705 407785 66377 78330 67264 68375 68202 230075 67273 66108 28080 66416 11950 68197 27425 17705 17706 17993 17720 407790 67942 68342 14939 71679 68349 72900 17721 17718 17991 226646 225887 54411 66046 67126 11958 11947 17716 68055 11957 70495 57423 67130 17722 69875 11946 17995 17719 17717 EPO receptor signaling%WikiPathways_20260211%WP1249%Mus musculus EPO receptor signaling 13857 16452 20779 30955 14784 13856 20416 228026 20846 26417 26395 26396 11651 26413 12703 20851 12700 20850 20848 19264 19273 110157 20662 384783 16367 218397 Arachidonate epoxygenase epoxide hydrolase%WikiPathways_20260211%WP1250%Mus musculus Arachidonate epoxygenase epoxide hydrolase 13850 12858 12868 13850 Metapathway biotransformation%WikiPathways_20260211%WP1251%Mus musculus Metapathway biotransformation 13120 64580 14860 110198 70646 69083 394433 17961 394433 56050 104086 17423 71519 14263 83398 50785 14872 72054 81906 15476 211666 15478 320997 14775 60322 22017 107146 140483 12012 14262 76969 14857 13081 53374 394430 56362 394434 13116 102294 56441 14865 14776 110115 394436 13077 11677 195646 269854 14778 13078 14873 77951 74134 20860 13075 13079 546726 20859 50786 13115 232174 14871 58810 14261 67877 552899 21743 18113 68312 545817 98956 58250 71367 330217 13122 14874 54371 13107 53897 319415 76263 545276 23908 13124 13076 14782 29859 50787 13072 14866 552899 15531 16497 67553 71797 13123 13070 72094 98388 69083 13849 66176 269642 20887 72117 628779 625249 244209 54710 54200 545963 14854 14780 13850 56773 14862 16499 55990 14859 16498 70999 226564 13082 13106 72136 73671 328779 13074 26887 56615 67861 68396 94284 14858 14870 12846 22236 66447 208665 68214 14866 381334 68947 13121 59031 Amino acid conjugation of benzoic acid%WikiPathways_20260211%WP1252%Mus musculus Amino acid conjugation of benzoic acid 107146 60525 Type II interferon signaling IFNG %WikiPathways_20260211%WP1253%Mus musculus Type II interferon signaling IFNG 20847 15978 20846 20375 16391 15900 16452 16451 17329 12703 13058 19247 15894 16363 15980 14468 21354 15979 97122 15977 16176 19106 100038882 18126 16362 15945 16912 12702 18753 16364 15958 12265 19692 Apoptosis%WikiPathways_20260211%WP1254%Mus musculus Apoptosis 58801 12371 17246 12018 22031 16362 18033 14102 11797 66593 11651 14940 94185 12015 18035 12362 19766 16363 18036 16992 12363 54139 12367 18646 21937 16001 19697 12675 12028 11783 21938 11796 12122 85030 26414 22029 16150 27056 13347 54131 12366 12123 22062 72193 12369 17869 21926 16002 12905 16151 51800 22030 12633 12050 18708 71609 11799 16000 21933 16476 12177 13368 12043 54123 12048 16364 18037 22059 26398 12370 11798 14103 22035 15201 14082 17210 12368 12125 26401 22061 Nod like receptor NLR signaling pathway%WikiPathways_20260211%WP1256%Mus musculus Nod like receptor NLR signaling pathway 59079 12675 16151 19697 26419 13844 26409 16150 21939 Mismatch repair%WikiPathways_20260211%WP1257%Mus musculus Mismatch repair 16881 18971 17685 19687 17688 17350 26909 18538 68275 Homologous recombination%WikiPathways_20260211%WP1258%Mus musculus Homologous recombination 67967 19361 12190 68275 27354 19365 69745 11920 623474 17535 18971 68275 18972 19360 Retinol metabolism%WikiPathways_20260211%WP1259%Mus musculus Retinol metabolism 63857 63954 11668 320092 19401 19378 67470 77974 19682 20148 232174 237636 56847 27409 16956 13106 19892 170752 20778 54200 545963 79235 20182 98711 67442 19659 20181 26876 20887 13082 12491 19411 235033 11522 20183 12904 12903 19771 19660 19662 218772 ErbB signaling pathway%WikiPathways_20260211%WP1261%Mus musculus ErbB signaling pathway 216148 56637 83961 320207 13869 23797 18803 12223 26419 13867 211323 13649 13866 11836 12015 11839 14388 13712 21802 20662 20779 14784 18183 13874 17869 20850 12575 26395 16476 15200 13645 13685 12928 18750 12576 12322 56717 15461 80794 70584 17973 26400 26413 14083 11350 100042150 Aflatoxin B1 metabolism%WikiPathways_20260211%WP1262%Mus musculus Aflatoxin B1 metabolism 110198 13077 14871 14862 13849 Mitochondrial gene expression%WikiPathways_20260211%WP1263%Mus musculus Mitochondrial gene expression 21780 15161 224481 15278 226169 66410 545725 14390 216151 26379 18181 213054 20683 19017 170826 17876 12326 12912 19055 Estrogen metabolism%WikiPathways_20260211%WP1264%Mus musculus Estrogen metabolism 12846 94284 13077 394436 20860 20887 18104 13076 394434 14857 22236 14862 13078 Polyol pathway%WikiPathways_20260211%WP1265%Mus musculus Polyol pathway 16548 230163 11677 20322 SIDS susceptibility pathways%WikiPathways_20260211%WP1266%Mus musculus SIDS susceptibility pathways 20271 11516 16153 21990 17161 20683 15205 12268 19712 15550 212139 13018 18095 20191 108015 21926 328572 625018 14461 16511 13195 12391 11998 11517 19017 170826 16917 11438 18044 16535 17172 19883 54006 15558 22355 13798 16193 22608 14462 22354 216343 15567 217946 15510 18992 260298 230857 14695 11835 14235 16194 12912 16535 14815 11859 19713 15208 27140 18033 18088 18935 11444 Fatty acid beta oxidation%WikiPathways_20260211%WP1269%Mus musculus Fatty acid beta oxidation 97212 11364 231086 66853 12896 11409 13177 93747 270076 15107 231086 11370 14571 433256 13382 60525 21991 14626 14081 67460 15450 57279 11363 12908 16890 216739 12894 12895 50790 14933 67717 12651 110446 74205 16956 Endochondral ossification%WikiPathways_20260211%WP1270%Mus musculus Endochondral ossification 11647 20750 14184 17386 11595 12166 16147 14182 16002 12161 16000 67760 21803 12283 17260 12824 23794 12399 19226 14172 12313 20259 12393 14173 20679 19206 18605 18747 16568 58250 13039 21808 11651 14634 208715 22339 17395 12406 12162 12577 20682 21833 20846 11504 14600 18792 17313 20851 12813 240913 16001 21821 18214 12020 58214 20378 18791 208727 19227 19228 20678 21859 Selenium micronutrient network%WikiPathways_20260211%WP1272%Mus musculus Selenium micronutrient network 14775 19215 11689 17708 14782 103711 19223 64292 21391 17769 98256 14776 56473 20363 75512 80795 22436 238505 76267 17709 12359 14778 625249 Folic acid network%WikiPathways_20260211%WP1273%Mus musculus Folic acid network 64292 19223 75512 56473 12411 26462 12359 17769 98256 14776 19215 80795 20364 14778 238505 11689 27361 14782 22436 50493 103711 14775 625249 Oxidation by cytochrome P450%WikiPathways_20260211%WP1274%Mus musculus Oxidation by cytochrome P450 13082 66427 72017 320997 109672 13078 266690 123956256 320635 110115 13115 72054 546726 13121 13123 13075 13079 232174 13122 545817 13124 74134 56050 244209 13116 13120 13077 102294 71519 81906 13106 13070 77951 18984 13074 104086 13107 109754 13072 13081 13076 GPCRs non odorant %WikiPathways_20260211%WP1396%Mus musculus GPCRs non odorant 14829 56696 99633 108068 18387 17201 12769 19218 208188 12777 12614 54393 18168 15558 20132 70839 54140 13051 11551 58861 15566 18441 67168 19228 319430 13349 225192 387349 14293 11555 14427 15465 17202 107934 14766 22354 20607 14365 57385 16867 19216 14367 12771 12000 114229 217369 13489 242093 15562 12672 57252 18430 213527 69296 11542 18442 140741 12311 99633 242425 20605 93746 13490 57253 387285 20608 18216 230777 12671 19214 22045 111174 14816 107221 94226 244701 319757 12669 14309 230775 110168 107831 18167 210198 12922 18101 69412 78826 14744 54598 13492 14652 246313 13610 11554 57265 11517 15557 387616 211578 11552 11607 99296 108073 11539 14602 15564 19220 381853 14370 387344 387355 210933 12773 319239 13491 18386 574402 53883 11608 13617 140795 320463 12273 65086 14368 216749 14062 229214 11609 59289 667992 53978 11549 233571 213439 21338 381489 238377 11541 15565 12801 140498 70086 170757 11540 12770 12061 14739 15560 233079 233080 233081 18217 12921 387353 17200 15563 26364 93896 12425 14428 232431 330814 12458 104443 57260 54199 13611 22355 14823 12776 14369 12802 227288 239283 387515 84112 22095 14371 71223 14064 14767 213788 13618 23796 17171 108069 14063 381810 12426 12765 12767 11550 11556 12775 12766 57811 387347 574417 226304 12768 20609 19222 52614 21336 237175 14715 23832 13733 80901 319229 12267 11553 18390 319387 236781 14745 19065 268934 14065 12145 13603 80885 243764 74191 353167 17773 26361 227289 19204 16995 15551 239336 12374 20606 64297 14366 12778 15550 13609 18169 17203 30044 13488 78134 15559 353344 14765 12772 108071 76854 57254 12062 226278 19217 21390 207911 108072 11548 21337 18166 58182 19219 15552 15466 17199 18241 14362 14527 GPCRs odorant%WikiPathways_20260211%WP1397%Mus musculus GPCRs odorant 258927 381413 233221 233919 83770 18389 14747 238725 259005 12209 259013 229323 493809 240888 80706 67549 14608 404239 14762 258697 258734 387345 68151 218066 18312 353166 319197 229357 338346 212541 258725 78249 215855 383563 215798 237716 54672 18328 224792 18307 387342 107173 18316 52710 227326 58245 14160 209513 14763 258585 404242 76206 14788 18322 110326 258478 406186 243979 233230 113850 381628 258769 215854 12057 22296 113845 258770 80910 18315 113848 27216 113846 209512 276742 78308 171469 241263 387354 258565 64095 64378 236798 259017 436440 24100 233231 241070 100129 381974 73010 258319 70693 78560 321019 277463 113851 258318 259012 258728 353346 503558 238252 70771 257898 112408 22297 229714 77596 245424 113847 387346 113856 329252 71862 83771 353148 269053 233670 269604 228228 404240 258573 387514 80978 387340 57272 113853 258362 319200 14748 435529 353165 81006 387348 235854 387512 387343 23890 83924 258327 258939 14761 18373 235256 113849 258566 70713 14539 14764 56861 84111 14760 80290 387511 258498 387351 56544 382045 11536 64450 68526 244238 257890 258869 404238 243270 258742 258310 381886 243277 211577 258581 217302 239853 239845 217143 258923 387341 258738 209776 387513 387339 107515 14738 18310 239530 387352 GPCRs orphan%WikiPathways_20260211%WP1398%Mus musculus GPCRs orphan 277463 78308 67549 107173 236798 319197 76206 68151 70713 58245 68526 52710 240888 83924 435529 224792 436440 217143 24100 Oxidative damage response%WikiPathways_20260211%WP1496%Mus musculus Oxidative damage response 18538 12262 12577 12260 12273 21938 15139 22031 12043 12902 12015 11783 338372 26415 12540 22030 12268 12575 13067 50908 50909 56196 13063 51789 12267 26398 67384 12263 12576 22029 18037 18033 21926 13197 26401 26414 22034 12259 12367 12018 12371 Dopaminergic neurogenesis%WikiPathways_20260211%WP1498%Mus musculus Dopaminergic neurogenesis 18012 18424 12577 13799 16917 22408 14633 11924 17701 13195 20848 11668 320092 13162 13798 18088 18227 21823 17172 19713 18742 214084 14179 18096 14472 15376 110648 14632 20423 20674 21803 IL 5 signaling pathway%WikiPathways_20260211%WP151%Mus musculus IL 5 signaling pathway 11909 20851 12028 16414 56637 16409 12929 56484 18708 15162 23921 18709 12983 216148 12576 19229 12445 16185 16192 20963 11689 18033 20416 18751 20677 13430 26396 16451 26413 14784 18035 15894 18783 12703 16476 20850 22248 16653 22631 18753 13712 12983 15461 16191 12402 30955 26417 20848 20111 107746 16452 12387 11651 15163 110157 19247 606496 11690 12229 110351 26416 15170 20846 22324 26420 18712 53378 17096 19353 Regulation of cardiac hypertrophy by miR 208%WikiPathways_20260211%WP1526%Mus musculus Regulation of cardiac hypertrophy by miR 208 14463 140781 74318 327987 14613 17700 MicroRNAs in cardiomyocyte hypertrophy%WikiPathways_20260211%WP1560%Mus musculus MicroRNAs in cardiomyocyte hypertrophy 22416 20848 26417 16878 16973 213435 54720 18751 19353 208727 79221 18607 16000 26419 26413 12675 12572 12387 16151 11606 13542 73181 56637 23939 18706 13019 26396 18708 18709 26398 18033 16001 53859 56233 12700 19877 107951 19091 18707 18796 56489 26416 14183 107589 110157 13614 16150 16195 57265 16974 26400 74769 18710 211323 13645 17876 19056 11652 21803 56717 14173 26397 225724 23938 230899 18780 30955 21926 19878 26395 18158 15184 11848 22418 14463 224045 11651 19055 108058 66513 26399 14362 12313 Glycolysis and gluconeogenesis%WikiPathways_20260211%WP157%Mus musculus Glycolysis and gluconeogenesis 235339 13808 20528 21991 20526 13806 56485 106557 18655 14751 103988 13382 18598 14719 14120 20527 13807 14377 56012 18563 18534 16832 212032 16833 68263 27402 14433 18746 55951 18642 14447 18597 18770 11674 18663 17448 56421 20525 14718 15275 11676 230163 18648 15277 14121 18641 17449 16828 70456 Iron homeostasis%WikiPathways_20260211%WP1596%Mus musculus Iron homeostasis 22041 14319 50765 14325 66438 64602 84506 21926 16193 69585 15216 16194 53945 16175 Cytoplasmic ribosomal proteins%WikiPathways_20260211%WP163%Mus musculus Cytoplasmic ribosomal proteins 20084 27367 20005 19896 11837 56040 22121 26451 19989 19988 27176 110954 270106 19921 19933 19934 19943 19944 19951 57808 54217 27050 16898 20103 20055 20091 20042 27370 26961 19941 19946 19981 67945 19982 20102 20104 20115 20116 100040298 27207 20054 54127 20090 14109 67186 269261 66480 319195 67025 19899 76808 108168140 268449 68193 19942 114641 68436 619547 66489 100502825 67281 67671 67891 67248 67097 68052 20044 16785 267019 20068 20088 20085 67427 66481 66475 75617 57294 78294 20111 20112 110651 58988 Glutathione metabolism%WikiPathways_20260211%WP164%Mus musculus Glutathione metabolism 23887 14598 14775 14782 16790 110175 14857 68312 14776 14854 14629 15926 14598 14630 14778 14872 75475 14871 625249 14381 14863 13479 68044 Apoptosis modulation by HSP70%WikiPathways_20260211%WP166%Mus musculus Apoptosis modulation by HSP70 21937 12371 12370 12366 14082 26401 19766 14102 12367 18033 193740 12368 11783 26414 12122 12369 26926 Acetylcholine synthesis%WikiPathways_20260211%WP175%Mus musculus Acetylcholine synthesis 13026 18598 11423 18597 18618 12660 12647 Mechanisms associated with pluripotency%WikiPathways_20260211%WP1763%Mus musculus Mechanisms associated with pluripotency 13990 12914 19696 13016 21752 12578 17246 12575 20841 11819 13865 20683 213742 17480 14175 81879 18109 12168 17128 18128 20130 22418 17344 19164 22018 13380 12622 18033 13590 19280 50764 13445 17191 17192 75560 108155 22196 59024 15182 21849 22632 56380 19821 26424 21414 104383 65969 22592 13197 328572 51869 226442 66830 11614 22764 17865 16600 13211 19712 59016 15161 18999 26417 21432 21386 15901 14465 18986 18451 14388 16451 216233 16195 16880 16878 11789 12005 16842 22773 94093 56717 11651 17869 12591 12443 20848 99377 15221 71950 20674 13194 22059 353283 19211 18707 26395 110157 15461 17126 21812 18119 51810 14182 12159 11477 17125 12550 12387 21415 16412 56637 13542 208727 269424 14362 16973 22416 19247 14784 22702 328572 22286 26380 13619 22772 104156 21420 18424 69890 56353 628746 21888 19664 58198 14281 54624 209446 81601 20662 16324 21803 17131 14030 20588 11545 13018 22097 17342 76804 104263 22715 16647 12367 65079 12505 26413 18103 21425 110147 54427 16367 16337 16333 20423 319757 77683 102060 17977 13017 18747 13435 13436 21418 20230 212712 77766 20750 59004 66894 12912 18140 26611 74178 14176 13164 231413 14797 18712 223775 18260 11909 15894 12189 22218 52463 20997 21331 14472 13864 22025 22668 252870 104248 23988 19877 19878 18752 103551 16009 57278 76509 64058 13139 15260 63913 15162 269275 93762 20833 20689 107932 15078 22589 93960 51792 18291 14566 11479 17765 19646 245688 52615 16468 18158 18160 69719 13347 14056 17127 14055 13626 233726 16211 57258 226432 20687 21750 15111 12934 20591 216850 381022 22289 17260 17261 17927 75788 20393 83814 15251 73693 16598 15201 13433 22083 235497 214498 66317 74766 19651 12566 19698 76893 17975 17089 21848 22160 332221 67155 18854 99982 234366 19697 20586 229542 66923 433759 116870 20466 12224 23942 76007 21886 One carbon metabolism and related pathways%WikiPathways_20260211%WP1770%Mus musculus One carbon metabolism and related pathways 214253 14780 20655 246277 212862 13361 13026 232087 14782 236899 75320 99712 20657 11720 67305 107869 14854 218865 13435 64918 17769 13429 18805 20656 75512 12651 14415 12583 14417 14711 12116 20425 68671 192166 625249 14776 14775 238505 14630 14778 229709 12411 74129 12012 108037 12660 22171 14629 18618 12035 14629 12036 14630 268782 14854 Kennedy pathway%WikiPathways_20260211%WP1771%Mus musculus Kennedy pathway 320951 99712 18618 12651 20397 19210 12660 236899 68671 75320 13026 214253 212862 27388 Heme biosynthesis%WikiPathways_20260211%WP18%Mus musculus Heme biosynthesis 11656 14151 19044 12892 15288 11655 17025 22276 22275 GPCRs class A rhodopsin like%WikiPathways_20260211%WP189%Mus musculus GPCRs class A rhodopsin like 258416 258501 20606 54140 12062 258605 11554 93690 258604 17200 258740 18169 257912 26361 258883 258173 23796 14608 74191 11540 57251 15550 13491 56858 258433 20609 13490 258589 259034 18217 20607 14309 64095 12772 212541 17199 15465 259036 56014 15562 21390 14427 258607 14429 19219 258333 18389 12209 14747 258475 14763 30044 194433 12425 11608 56015 18313 258776 12766 258597 76854 12672 13603 14765 257902 20605 15551 11551 12000 12801 12768 15466 11552 14761 14748 14428 18216 12061 19216 258046 11556 257959 11609 13618 14762 12802 17171 29845 258499 19204 80706 233571 258498 19214 170732 14291 11607 258500 15564 22045 12145 12669 15563 12765 17773 18442 18168 16867 81006 69296 11542 258242 15557 258594 14062 258310 12267 11553 11550 258497 14064 243764 20608 16995 258868 11549 54393 258430 258882 11548 17203 258811 14760 21462 258328 23890 14065 15565 12769 19220 15566 258434 18429 14294 12057 12771 84111 18441 12770 15559 14738 406176 140795 320463 18312 258603 19217 12773 66786 259037 258794 258269 84112 258826 18390 258415 18430 14293 18386 14290 18348 12776 258802 13051 56861 19218 14744 12426 54199 57811 58861 29849 19222 258323 259035 18387 15552 18101 69412 14767 15560 14063 19065 171469 18343 11541 18316 80885 59289 70839 11998 14539 258742 11555 18166 20132 18317 14764 18314 18167 233670 258276 258431 17202 57385 29846 12671 12273 14289 15558 12767 12774 12458 14829 258350 22095 17201 12778 Cell cycle%WikiPathways_20260211%WP190%Mus musculus Cell cycle 12545 12532 22390 12550 208727 21803 12531 17216 268930 12567 12575 12442 12649 12445 15185 12566 50496 71890 30939 19650 27214 242705 433759 18392 56150 104394 17219 15183 19650 19645 19090 66671 56452 140557 12427 18538 17127 12576 56233 12571 27401 50793 17218 12530 209091 50883 17246 12444 328572 11350 17120 105988 12428 56637 21781 12534 17217 218294 12235 12447 15182 12236 54610 12237 12544 22628 13557 15184 12448 26428 18393 13197 17215 12578 22059 13555 268697 11920 17128 18817 229776 13559 17220 17476 107995 26429 23834 245000 Hepatocyte growth factor receptor signaling%WikiPathways_20260211%WP193%Mus musculus Hepatocyte growth factor receptor signaling 107746 110157 215449 20779 14083 12928 19229 19303 14388 19211 15234 26396 218397 26411 17295 26395 109700 13712 109905 26413 18479 26419 18706 12929 20848 15461 20662 16476 14784 16412 330662 19247 26417 14281 Splicing factor NOVA regulated synaptic proteins%WikiPathways_20260211%WP1983%Mus musculus Splicing factor NOVA regulated synaptic proteins 12390 13822 225724 12558 66354 65945 16522 76707 16531 12361 26562 14406 26420 67972 18798 110351 13852 12325 54725 18007 12361 268566 13131 11804 16536 20911 269587 13823 12661 80883 57321 13640 14812 14810 11735 14806 18762 242425 13821 94332 17758 11603 12994 Complement activation classical pathway%WikiPathways_20260211%WP200%Mus musculus Complement activation classical pathway 50908 12260 50909 12259 12262 230558 17174 12263 12266 12279 110382 12274 12268 13136 625018 109828 15139 Ptf1a related regulatory pathway%WikiPathways_20260211%WP201%Mus musculus Ptf1a related regulatory pathway 18609 19664 18096 12387 15205 19130 18128 14165 18519 19668 19213 18609 Hypertrophy model%WikiPathways_20260211%WP202%Mus musculus Hypertrophy model 22388 13685 16177 18124 16175 15978 13684 22339 11910 21417 16478 17700 11487 16007 107765 56405 15200 15982 17928 16173 Heart development%WikiPathways_20260211%WP2067%Mus musculus Heart development 15214 22341 26413 17125 14179 14106 14463 12387 18091 13867 50916 19247 21388 18128 12168 57246 20893 17260 12180 12156 17300 12154 387163 14234 15213 387136 73181 16392 387161 18018 21385 22339 12166 20423 22340 14165 14465 20807 17128 15111 18019 109575 15376 12159 18741 18021 15110 Nucleotide GPCRs%WikiPathways_20260211%WP207%Mus musculus Nucleotide GPCRs 67168 11540 69296 11542 16995 11539 233571 57385 18442 18441 78134 11541 Neural crest differentiation%WikiPathways_20260211%WP2074%Mus musculus Neural crest differentiation 12162 11852 17863 16412 22408 21418 22771 18505 18509 13395 17703 17702 15221 20613 20583 22416 14365 56637 12387 21415 21413 14472 12006 12005 13544 13543 13542 12159 17125 15901 18128 13389 18132 18129 54485 18131 13388 15214 22160 20665 14173 15208 15205 19664 14182 14183 14184 65100 107771 20682 16392 12563 12558 12550 20678 23871 18033 241201 18034 18014 18935 14580 50914 50913 14618 17172 17342 18858 17528 17196 16869 16870 14179 14170 433759 15182 15183 208727 15184 15185 56233 70315 79221 170787 232232 13017 13190 12824 12815 12587 20890 15407 235472 94222 21389 15394 16873 21909 21419 140477 15110 Alzheimer 39 s disease%WikiPathways_20260211%WP2075%Mus musculus Alzheimer 39 s disease 234664 11820 11785 11487 23821 66340 19164 59287 226548 15925 17380 16956 11816 16971 14102 21937 14082 12370 15108 12122 12314 56398 12015 70405 80796 19055 19056 19057 19058 19059 70261 11491 19165 11783 12371 12367 20617 14810 12288 14811 14812 14813 14814 12289 54652 12292 14682 18795 18796 18797 18798 21926 16176 26413 26417 12364 20192 11938 11937 53313 13666 78943 226641 16438 16439 16440 12333 12334 22059 12569 18125 12568 17762 56637 12369 Serotonin receptor 2 and STAT3 signaling%WikiPathways_20260211%WP2079%Mus musculus Serotonin receptor 2 and STAT3 signaling 15558 16452 14682 20848 SREBF and miR33 in cholesterol and lipid homeostasis%WikiPathways_20260211%WP2084%Mus musculus SREBF and miR33 in cholesterol and lipid homeostasis 20787 19017 50721 15357 93759 56717 22259 19013 723897 94112 20788 16835 Serotonin and anxiety related events%WikiPathways_20260211%WP2140%Mus musculus Serotonin and anxiety related events 15558 11838 15560 15550 14281 56193 19055 18751 18802 14814 192167 12921 12918 Serotonin and anxiety%WikiPathways_20260211%WP2141%Mus musculus Serotonin and anxiety 18802 56193 18976 14816 193034 18751 12323 14265 12918 19055 13629 14394 11838 15560 14281 15550 11549 11838 13629 15558 BDNF pathway%WikiPathways_20260211%WP2152%Mus musculus BDNF pathway 18791 12064 18212 12043 327826 22059 18815 225724 12912 19353 12028 20416 12540 18053 18787 12064 18815 Striated muscle contraction%WikiPathways_20260211%WP216%Mus musculus Striated muscle contraction 21925 21956 12373 13346 21955 17897 21924 22138 13405 22003 21952 17996 21953 11465 17868 17879 22352 17883 11464 22004 11474 233199 17884 17906 326618 11472 109272 21916 17896 17885 17929 17888 98932 66106 21957 21954 11475 17901 17930 140781 59069 21393 11459 60595 71912 Purine metabolism%WikiPathways_20260211%WP2185%Mus musculus Purine metabolism 102216272 108143 18605 75686 209558 633979 73532 73532 18605 68870 215446 18770 18573 14198 242202 20020 56520 69833 667034 18577 50773 16434 20021 110385 171567 667034 210044 23984 18950 18576 14450 23959 225600 18102 18102 230718 27369 75533 76952 18968 70881 171567 18746 18573 18968 66355 67486 18577 218461 72090 76952 18969 15452 230718 230103 11636 215446 18574 11637 382985 67967 67710 103850 18950 70881 54611 15452 26939 12496 76974 72090 69745 16434 11512 18746 66358 238871 107569 20016 20020 18969 229665 78929 64424 18583 18974 18574 66401 215446 19139 71701 18950 11514 20016 667034 54369 229949 667034 230718 70881 231329 18973 241489 107569 108147 69241 16434 18584 14544 11566 18588 171567 105446 239134 54369 218461 66136 18103 54195 56520 18583 229589 667034 234889 18575 245650 20133 11821 20018 66401 67464 56520 94041 18103 72090 18584 103850 20135 70408 67054 11486 23959 18973 74414 11821 66491 66979 11514 54611 14450 230718 18972 19075 76952 12495 69745 382985 224129 18971 18950 20022 18582 79059 229363 23972 79059 207728 78801 54369 78801 76952 23972 14919 72090 11565 18102 11515 11821 67967 20135 15452 14450 20017 215446 11564 22262 14923 103850 11636 20022 18770 20018 60596 67486 69241 11486 23959 18103 14918 16434 432530 59001 18770 74414 11639 103850 54369 23971 23918 19075 13178 66979 18578 12497 20133 110385 12495 215446 12495 20019 75533 23918 66420 238871 56520 210044 79059 271639 75456 14917 59001 53893 78929 50773 231903 110639 66491 50773 20017 69920 18102 667034 76952 103850 67005 229949 76025 69870 76952 23959 12497 79059 70428 75533 19076 75533 12495 18974 29863 11534 224129 72157 18746 69870 67464 107569 18746 69833 218832 18160 11639 18950 66681 18585 76025 11515 70881 107569 50773 50773 12499 20021 104110 18950 72090 230718 18578 70881 12495 72090 18575 64424 11513 230718 22436 207728 16434 66136 245841 20019 19076 50773 11717 12495 104111 107569 11564 23917 18972 23959 103850 67005 110855 18770 23984 67054 328099 26939 215446 70408 171567 18576 11637 218832 70428 432530 231327 245841 104110 12499 23959 18971 109674 66420 66401 104111 14923 71701 67065 70881 69920 78600 107569 231329 11513 67710 271639 18587 29863 67065 23971 11512 108147 241489 74167 237823 18103 100862375 68695 Cytokines and inflammatory response%WikiPathways_20260211%WP222%Mus musculus Cytokines and inflammatory response 16175 16176 21803 16153 12504 16187 15962 16189 16163 12977 16196 15978 16183 12985 21926 16168 16191 14825 330122 16193 16160 16156 12981 16159 18590 15977 14969 Macrophage markers%WikiPathways_20260211%WP2271%Mus musculus Macrophage markers 12522 12475 12514 14066 93671 12524 16149 23833 19354 17105 Chemokine signaling pathway%WikiPathways_20260211%WP2292%Mus musculus Chemokine signaling pathway 13051 216869 66102 14710 20301 100039863 100040048 12929 14706 20299 18708 22325 56484 18747 210044 20295 56637 57349 12928 14700 18751 14678 19354 19353 16452 12540 110157 277360 20303 14697 18709 14707 12776 20306 18033 12675 14083 12988 21844 14695 18710 18798 94176 109880 12770 20308 20312 17096 18749 224129 12771 23832 19303 20416 12777 66066 56744 16453 18479 73178 20311 12927 14702 19395 20846 20418 74769 20290 18707 12775 606496 12768 110355 22324 20847 20292 26385 18797 17329 216148 320207 80901 57266 20307 20293 14679 20851 12773 271849 14708 12767 14688 26413 18762 16428 14784 18706 19877 19108 19878 19697 20662 12766 14701 100503710 14709 11513 109905 16653 16963 20663 18796 11652 12774 12772 20315 14825 17969 14699 15945 56221 14772 12458 20302 23797 12769 18795 16150 20305 15461 56838 93742 24001 20296 11651 227288 20309 57257 18176 14191 19229 14696 22376 24047 18762 20300 26417 104111 24013 104110 11514 20301 100039863 100040048 64337 11848 140580 15162 55985 14677 18035 20848 12145 541307 11515 26395 18753 14693 20304 18036 14773 215449 109689 18829 20310 16151 432530 20297 14704 12765 11512 30955 PPAR signaling pathway%WikiPathways_20260211%WP2316%Mus musculus PPAR signaling pathway 235674 19015 69050 19016 22190 74551 666168 13124 22227 26457 15360 13117 20182 11832 20250 11430 13118 30049 329065 22259 20181 328845 14080 13119 20183 20182 216739 57875 104086 74205 12140 11364 12895 78070 20181 277753 14077 100040843 14079 50790 13167 26458 26569 11807 12491 26457 14080 17436 11450 11814 433256 11770 19013 56473 20183 13122 18830 14933 103968 26459 80911 66113 93732 18534 12896 14081 16204 20182 83996 108078 26569 230639 12491 83995 225579 435802 94180 20280 20249 16956 16202 11806 14626 14077 20183 12894 20181 20411 11770 16592 74147 18607 11363 113868 Fatty acid oxidation%WikiPathways_20260211%WP2318%Mus musculus Fatty acid oxidation 15107 93747 11370 11409 52538 15107 93747 17777 11364 12896 12894 214663 G protein signaling pathways%WikiPathways_20260211%WP232%Mus musculus G protein signaling pathways 19088 14700 29863 104111 224129 14701 66066 56399 19057 11640 19085 14683 18753 14695 18577 18574 14682 14681 238871 18751 20130 14675 238276 14687 104110 218461 18176 64337 14699 14693 19084 14672 18755 19055 14677 12313 18749 19087 14697 16519 18797 432442 14674 11512 11642 18573 18575 210044 14680 18760 75292 11515 238161 432530 75547 14676 18584 83397 11848 11643 14679 219181 14710 18761 110385 14709 18754 14708 18752 14688 18750 18759 14707 14704 15461 18762 16801 56697 11514 11513 18747 18578 16653 18583 100986 14706 14673 16438 20544 14678 GPCRs peptide%WikiPathways_20260211%WP234%Mus musculus GPCRs peptide 12426 22095 21336 12776 12770 18166 26361 12061 20609 12000 17200 19065 12267 14309 18167 16867 18430 12773 12766 12145 12769 13618 12768 18386 17202 14429 18169 20605 17199 12273 11609 18390 20606 18387 21337 14428 22045 18217 80901 18101 69412 20608 14829 54140 12765 13051 17203 208188 17201 13617 12062 12767 14294 12774 12777 18389 12771 14427 12458 11608 11607 18168 12425 18216 12775 12209 14293 12772 21338 14715 20607 miRNAs and TFs in iPS Cell Generation%WikiPathways_20260211%WP2375%Mus musculus miRNAs and TFs in iPS Cell Generation 68479 70052 53607 53817 18999 20674 75062 Osteoblast signaling%WikiPathways_20260211%WP238%Mus musculus Osteoblast signaling 19226 18383 18595 21943 19228 64654 12842 218103 12097 18596 Alanine and aspartate metabolism%WikiPathways_20260211%WP240%Mus musculus Alanine and aspartate metabolism 14415 268860 226414 11484 109900 76282 18563 11898 14718 11611 14417 14719 11564 12908 107239 Spinal cord injury%WikiPathways_20260211%WP2432%Mus musculus Spinal cord injury 18053 69583 16995 24099 19283 18610 16994 18845 121021 16423 22695 14130 381833 19262 16176 18126 21926 15370 16189 12227 12566 18125 16183 16193 21898 14281 21803 13653 17381 15978 17196 68585 15139 14825 11829 11846 13838 13642 15945 12450 17395 13004 20562 20563 20564 18208 244058 12772 16177 16175 20310 20296 53357 18784 18780 16952 15894 20344 259277 14580 12567 21336 13559 19645 18750 13555 26413 12443 17869 13197 26417 12367 22059 58250 13003 12826 233781 12824 11595 12032 20682 14810 22352 19055 14432 14225 17136 11848 11853 11852 19878 18377 65079 18733 50490 387217 12534 14573 20358 14609 12064 TNF alpha NF kB signaling pathway%WikiPathways_20260211%WP246%Mus musculus TNF alpha NF kB signaling pathway 23881 69721 14113 18036 15516 72508 230233 544963 57751 12366 56489 16709 328949 19698 16648 16151 12389 20340 26401 19179 19182 12335 26410 17846 11651 13001 22627 20016 103583 18567 15519 56637 21926 26965 56456 19766 19697 71833 66997 211550 21938 22032 12905 19052 12995 22030 16650 80859 67891 18035 22196 26572 74256 22682 245841 11797 22629 109658 22034 68652 70247 56532 17463 22031 21941 446099 14082 12234 18033 21937 17218 23938 71966 192176 18616 15182 64424 21353 22631 53859 14886 14229 68052 19946 22033 219158 12367 22628 333654 56480 57783 26961 67384 18034 73086 20587 14694 18037 26405 231130 76784 19696 12675 68094 11652 26885 21934 20018 21929 54401 14084 57376 18854 12633 192656 27215 12370 11796 22036 53376 21402 16150 12539 19708 15507 66724 22029 192170 20586 76589 14388 433759 23997 23980 211651 229615 16535 26406 18747 12914 19181 70333 20779 15185 18762 216150 17220 320795 108086 20588 22218 18201 27207 14083 11647 71609 20019 12051 22026 77045 13000 22123 66413 12369 226525 20017 236733 13728 56399 18789 20846 16647 13205 19988 18637 223453 72416 19247 56407 19173 66513 Mapk cascade%WikiPathways_20260211%WP251%Mus musculus Mapk cascade 26416 16476 18176 110157 26406 26401 26417 13712 17756 26398 15461 26404 26414 26396 17196 29857 26399 20469 26413 19414 20130 11836 16653 26405 109880 26395 26397 18797 Androgen receptor signaling pathway%WikiPathways_20260211%WP252%Mus musculus Androgen receptor signaling pathway 12534 433759 11835 20779 27057 14815 15469 19645 104156 59004 13982 12017 97165 110157 20602 16476 12317 56218 217127 20848 11651 56736 12447 30051 19822 56424 12393 16195 223870 18987 23957 22196 11909 16000 17128 18193 12859 12387 14797 68098 16193 14884 12389 67655 56705 22294 66671 19211 72993 14200 98053 22215 108767 19697 13649 14600 17344 22059 268903 214230 12572 328572 11739 192176 81000 15259 26395 12362 22634 17978 12189 13983 22026 21815 229615 12531 83995 12370 21674 12367 12369 193740 18813 26423 225115 11614 12914 12443 17977 17246 22629 19384 19303 56469 21804 17979 17127 170758 20683 81601 18986 26413 68705 107951 20466 19183 232286 12394 12539 Primary focal segmental glomerulosclerosis FSGS %WikiPathways_20260211%WP2573%Mus musculus Primary focal segmental glomerulosclerosis FSGS 16410 21898 12323 11651 13429 67703 16416 22330 16449 243911 17973 12476 13039 19277 16776 13380 14360 18793 14083 54139 22370 22630 104027 21803 11603 12488 16691 170484 16779 54631 18803 12576 12946 18504 27205 16917 71602 12492 14107 192897 12830 12577 17380 22352 12575 74055 60595 17886 54380 22431 70435 22068 18538 17345 12558 12737 12828 12829 110829 12519 18128 12387 16974 16973 21894 16202 16412 16400 13138 57342 22288 TGF beta receptor signaling pathway%WikiPathways_20260211%WP258%Mus musculus TGF beta receptor signaling pathway 12234 21813 13018 13559 11910 18519 16477 17260 216080 108058 21417 19877 16476 19651 18046 54601 24136 71770 13805 17127 21814 21402 218210 217232 12567 104394 12393 12387 19645 12575 21812 19087 66354 26416 15228 52206 18045 14106 17131 216869 66313 69957 56438 75901 17126 16842 26399 21781 21803 68999 22062 22601 17869 12443 26965 22337 20683 59008 230597 69150 20482 56317 12389 21809 103573 14225 18708 14272 17128 75788 12505 18709 99152 26754 386655 12534 17344 13163 11909 23871 21815 12914 71728 14281 76793 21808 11835 72183 20869 14282 227720 18753 26419 19650 13542 56371 15405 16478 18751 17130 66513 52563 20481 26397 328572 66105 211586 12005 20901 15481 76630 93742 16211 13132 22218 15239 12442 13982 17258 12530 56550 54709 12006 19085 15529 12571 17222 56469 67804 12447 26409 56484 11482 56440 18044 17977 67903 68015 56458 59079 12566 71978 433759 12323 12322 12325 22059 15378 20692 12705 Delta Notch signaling pathway%WikiPathways_20260211%WP265%Mus musculus Delta Notch signaling pathway 18128 18129 18131 18132 13388 54485 16449 16450 19164 19165 208117 66340 59287 11487 11491 56637 18222 16396 11820 18223 18708 18709 11651 18550 12805 18133 14357 17172 328572 22059 16848 17305 140484 21402 50754 15213 270118 433586 103806 66354 20602 20185 433759 66935 60406 15182 20466 15205 20848 16452 19697 18035 15214 21885 17127 17128 22632 12566 16842 17260 26965 27401 21423 26417 26413 57750 14199 19763 16656 56381 17125 55927 22761 17137 12804 12803 15208 16818 16476 19664 13645 13649 Ovarian infertility%WikiPathways_20260211%WP273%Mus musculus Ovarian infertility 12167 19116 14309 16867 22788 13404 11920 17350 17687 14566 22787 20597 13164 14612 16322 17127 18667 13983 22337 26423 21374 20185 268903 13653 12608 19217 12576 12444 12567 13075 319565 B cell receptor signaling pathway%WikiPathways_20260211%WP274%Mus musculus B cell receptor signaling pathway 13712 15184 18021 14784 12444 26413 19058 11909 77799 18719 76709 12483 14389 19697 12042 218397 22324 107746 18604 72508 83490 13448 18718 18760 14388 68089 56743 18019 56233 20846 19264 12371 16439 12572 12571 15162 30955 16822 110157 14360 11867 26377 18803 17164 19645 66713 20848 12369 12518 22637 12912 208650 15163 26395 19247 16151 20111 117150 18709 68119 76108 18753 12053 16331 20963 12478 16150 12387 109880 14083 242248 12229 19696 56458 27261 77590 12902 12927 12929 17096 108723 12567 16438 18751 83436 26411 18720 11651 20663 12445 23921 18003 381290 56792 108083 12675 12125 26396 24055 12517 12928 18035 26419 240168 18754 67603 20662 15170 12988 12143 16818 12566 14886 11848 12028 225724 16476 18018 22325 18708 21682 319520 14130 74117 19229 234779 18761 12520 101476 17973 606496 16428 18607 22376 56637 15387 12402 26409 19253 12507 20104 12043 20416 72699 26417 12428 56378 15985 19055 67771 17060 26416 12447 19056 18717 Focal adhesion PI3K Akt mTOR signaling pathway%WikiPathways_20260211%WP2841%Mus musculus Focal adhesion PI3K Akt mTOR signaling pathway 12826 22084 53867 21828 19116 20662 12831 16420 105083 16453 16186 319480 12815 16780 14784 329278 20869 14599 16188 13857 16404 16409 12843 216505 15891 12832 18414 94216 21827 16398 16773 12824 12829 12985 192897 16402 16775 320910 381924 16416 16776 14083 12643 213119 81877 16400 12842 16403 13856 16410 16772 22371 12825 23797 16411 16414 16190 16399 12986 15976 23928 16197 21826 16421 15965 20750 14268 74747 12814 16401 16452 16451 22370 15962 15964 11651 74769 18707 14600 16194 12845 226519 16779 16185 18706 16774 16184 19211 16777 19699 75669 12827 64930 16412 241226 16407 104099 12834 16419 21825 16408 11652 18708 18709 16782 21923 15975 21960 320207 13636 14164 14166 14165 13637 13645 14167 12977 11602 11601 11600 22339 13638 13639 13640 14169 14168 14170 14171 14172 14173 14174 14175 14177 14178 14179 14180 14205 15234 16000 16333 16334 17311 22341 22340 18591 18654 18590 18049 54635 56636 67112 71785 80857 80903 14183 16542 16337 14184 16001 16590 14182 13836 13649 12978 14186 14254 14257 18053 17295 18595 18596 21687 67605 15967 15968 15969 15970 15972 15974 15977 16183 18413 19109 230396 404549 12669 14745 14062 243764 381810 53978 65086 67168 78134 14693 14688 100503710 14696 14699 14700 14701 14695 14702 14704 14706 14707 14708 14709 14710 64337 66066 30955 18176 16653 15461 72149 12283 69008 105787 108079 56716 19744 56717 74370 15251 22241 74343 12539 15516 98432 21432 18607 100039815 19053 19052 100039830 21770 225849 72930 73699 19054 235542 26931 26932 269643 51792 52432 226849 59032 15519 22027 244650 17763 27379 27380 110157 26396 26395 26413 26417 56637 56484 56458 16150 12015 12371 17246 16151 12576 12575 11909 12913 12912 11911 208647 208677 12915 26427 78284 231991 18127 57915 17274 59021 19325 19326 68365 20528 20525 20527 20526 19017 14936 232493 18640 18639 170768 270198 16890 20787 15375 107476 15568 18125 18126 13819 53417 58988 13685 75705 72508 20104 13684 26987 218268 240752 18704 18705 16367 16370 16369 384783 Gene regulatory network modelling somitogenesis %WikiPathways_20260211%WP2852%Mus musculus Gene regulatory network modelling somitogenesis 14179 21389 382089 17293 13838 84653 15205 16848 18128 13388 22416 White fat cell differentiation%WikiPathways_20260211%WP2872%Mus musculus White fat cell differentiation 22410 13591 20787 12606 12608 14013 19883 13198 12912 54131 20851 66277 12224 14461 21415 94187 13654 14462 11819 19016 22259 12609 12385 16600 19401 56458 20850 21887 16333 14815 16364 16598 Notch signaling pathway%WikiPathways_20260211%WP29%Mus musculus Notch signaling pathway 19664 16449 433586 14357 15182 13544 11491 13017 18131 103806 13543 13542 66935 59287 226548 19668 18128 20602 18222 209200 13388 66354 19165 54485 18129 18132 12914 80904 74198 15205 18519 207521 16848 433759 16450 19164 13016 13389 17305 18223 21926 19719 19208 208117 14534 15208 p53 signaling%WikiPathways_20260211%WP2902%Mus musculus p53 signaling 11920 50883 245000 12649 12578 17246 17248 22059 12575 12443 12444 12445 12567 12571 12447 12448 12566 55948 67874 268697 12442 209091 434175 12534 13197 17873 23882 29870 14102 57913 12370 12122 12028 58801 170770 13663 66940 64058 22401 20437 20438 13063 13067 11783 12371 12367 16009 16000 18787 107831 12521 21825 20724 107986 382985 20135 140742 230784 75747 19211 22084 68428 26374 68098 12450 12452 53892 22062 miR302 367 promoting cardiomyocyte proliferation%WikiPathways_20260211%WP2904%Mus musculus miR302 367 promoting cardiomyocyte proliferation 15235 50523 68473 22601 Mecp2 and associated Rett syndrome%WikiPathways_20260211%WP2910%Mus musculus Mecp2 and associated Rett syndrome 20185 17932 18996 11813 14175 12064 18015 20604 27528 53618 17257 18992 22608 14174 13006 14810 17260 21354 268859 12799 14056 14431 18387 622434 20466 20683 14415 270627 59013 13007 13395 57810 17932 12609 17196 12053 14409 13018 20687 70767 13555 19712 17136 14173 26913 52463 98758 22608 12912 miR 222 in exercise induced cardiac growth%WikiPathways_20260211%WP2928%Mus musculus miR 222 in exercise induced cardiac growth 12576 219150 15258 15257 Electron transport chain%WikiPathways_20260211%WP295%Mus musculus Electron transport chain 11946 230075 11958 11740 226139 110323 66152 12864 57423 28080 67942 66377 11947 68375 66594 66091 20523 72900 67130 17709 66218 407785 66694 17991 17720 17706 595136 12858 67003 11957 67680 17708 20463 75406 12861 74011 17993 12865 12857 27425 22229 66576 66108 66495 100041273 68194 100042503 12866 17722 68055 66945 17717 70316 66142 22272 11739 67530 17721 66414 52892 66925 11983 66916 54405 22273 66046 12859 17705 17710 68349 12868 17716 17995 66052 228033 12862 20930 227197 66416 17719 71679 68197 68198 226646 66043 68342 12856 17992 68202 11950 67126 11949 78330 67273 22228 17718 225887 17711 22227 IL 7 signaling pathway%WikiPathways_20260211%WP297%Mus musculus IL 7 signaling pathway 12125 12028 16362 20416 20844 12428 17829 14360 17096 20846 17210 20850 11651 16186 12567 208650 15461 12444 20662 16451 56458 26396 19229 26395 384783 16197 12402 18708 110157 12566 12143 12015 20848 26413 16453 16367 26417 19645 56637 14784 20851 67300 56484 56324 G13 signaling pathway%WikiPathways_20260211%WP298%Mus musculus G13 signaling pathway 20166 320795 12632 52428 11848 18643 16801 24068 14674 544963 29875 18707 11857 74769 59009 16885 53311 19353 51789 18481 18718 26414 12313 73178 18709 19046 22376 26407 17901 12704 14570 19877 13367 18706 12540 72508 19878 12631 Histone modifications%WikiPathways_20260211%WP300%Mus musculus Histone modifications 107435 433759 15182 77683 110147 Translation factors%WikiPathways_20260211%WP307%Mus musculus Translation factors 22384 13628 13690 224045 217715 26905 19106 13629 217869 55949 20918 68135 16341 13631 16418 13667 225363 13681 13682 13688 18458 13669 66656 13664 75705 13685 208643 78655 13665 66085 26908 276770 53356 108067 13684 209354 54709 56347 218693 230861 13627 18459 55944 108112 13666 67160 15467 67204 27979 mRNA processing%WikiPathways_20260211%WP310%Mus musculus mRNA processing 20020 74111 18139 68035 110957 22184 66679 237073 19847 20822 101943 207920 15382 67579 66055 24128 15547 20658 29813 234373 13206 66492 56417 20462 66164 109729085 67053 24014 117903916 27366 109075 66405 76167 72160 21744 12877 24018 75420 19848 19941 27041 68219 19653 69597 19826 74326 50926 102462 50911 57320 76938 76572 53610 67671 67456 19989 20624 66704 319695 20641 234733 53607 93728 53356 69207 20638 14030 20595 241490 66446 228410 54127 71713 246730 243272 20005 216578 70616 19106 321006 268859 72567 56031 69724 19845 67248 19357 23879 94191 71514 233908 231769 244631 100336 70233 235402 66585 66475 18789 108014 19657 229279 13205 12021 70052 58203 13164 80912 19134 68379 14007 140486 104307 56381 67842 19934 67949 19844 56190 192170 217337 56195 224344 68879 68278 384281 66185 18458 72935 15568 20630 67337 20853 20637 20639 17184 12748 13046 56009 66983 68598 20826 104721 338351 53890 12828 14962 319322 19862 115489655 66230 68092 13682 13211 27225 319586 56194 67936 108013 19017 72459 218543 52874 68172 20646 71713 70439 110809 107951 229279 77604 67197 83675 115488065 115488060 19842 18938 20090 57317 217207 75710 19844 320158 98985 68165 16201 15387 21843 239188 67418 77411 52521 192159 30959 23962 72735 98685 68479 246277 23983 69639 67434 20817 26961 353258 236732 57294 27275 27993 50783 19656 11428 22384 53379 230257 83410 66892 71766 170826 102857 21357 245945 193116 69192 269261 70044 12696 66599 230721 230603 15572 12189 67120 67025 229663 20821 19383 13690 272009 20975 15388 76626 26919 70930 27979 67710 67920 20823 77134 15469 16865 22034 52202 26987 19951 209224 67427 67465 381626 207181 13684 215615 53817 140488 51796 53975 18521 56758 72662 27756 78784 56215 53319 246727 231413 66094 20044 68272 108121 102414 19663 70767 230908 20088 22185 12750 64340 15571 20383 109095 11640 269061 69207 20826 19654 21752 75062 67667 54614 98758 213236 60365 51810 56316 11992 56258 56516 18459 20222 115488065 115488060 19842 20747 170722 16589 54451 11739 19205 27058 22380 14359 107686 23960 76897 217351 67010 19655 170791 66810 19935 74484 100861987 81898 69408 114896 53621 67959 71684 18542 51786 15569 20102 107701 224902 232089 230861 76846 67229 94230 13722 20384 68195 13680 11499 66419 20815 69878 66645 66660 66384 19921 68052 14265 59093 78304 73826 56335 67039 27998 72290 14208 72397 74213 106583 72054 246728 67390 100121 171190 59013 83410 67897 208606 13209 19652 100043257 75388 24067 24061 15468 56403 67889 80913 70248 21841 19317 13204 68011 76522 67207 71973 76938 19848 108657 380773 18670 68581 20813 100502825 67281 13207 15381 208718 56200 14105 14113 20382 54196 23961 67543 15384 53609 59092 67958 52513 17690 20462 208922 57837 11991 30947 56275 19845 108062 20238 20643 22099 21681 76183 67332 76936 67996 20115 54188 68744 66125 22608 218543 17975 27632 225027 56878 27207 20104 18148 192119 209003 53791 68981 67225 19656 20924 83486 20492 93871 67444 17876 12747 72692 56522 93686 Glycogen metabolism%WikiPathways_20260211%WP317%Mus musculus Glycogen metabolism 19309 19053 102093 232493 225849 68961 26931 12313 18679 269643 110078 216558 14936 606496 235542 27357 51792 12315 26932 19052 21770 72930 77559 226849 12314 110094 71978 56637 18682 73699 74185 72157 110854 110095 Eicosanoid synthesis%WikiPathways_20260211%WP318%Mus musculus Eicosanoid synthesis 11690 19215 96979 13479 19223 18780 11689 21391 19224 14598 53357 11687 11688 64292 16993 19225 17001 67452 11684 GPCRs class C metabotropic glutamate pheromone%WikiPathways_20260211%WP327%Mus musculus GPCRs class C metabotropic glutamate pheromone 14816 108071 108068 108069 14823 268934 108073 108072 12374 54393 242425 93746 70355 64297 232431 Fatty acid omega oxidation%WikiPathways_20260211%WP33%Mus musculus Fatty acid omega oxidation 26876 13106 11529 13077 11668 320092 11669 13076 11522 Fatty acid biosynthesis%WikiPathways_20260211%WP336%Mus musculus Fatty acid biosynthesis 14104 93747 433256 111175 52430 107476 52665 50790 20249 60525 67856 104112 74205 15107 100705 14081 18563 52538 26922 67460 216739 51798 ESC pluripotency pathways%WikiPathways_20260211%WP339%Mus musculus ESC pluripotency pathways 14368 23797 13544 66713 17125 56637 17129 17869 15461 12166 109880 18590 22415 14164 17131 22419 80903 18591 14177 14170 11477 14182 26395 12387 14366 67112 13542 16451 12168 16476 14165 18707 14180 14370 20848 20662 80857 11652 110157 14166 22421 14371 16195 14184 22418 23939 57265 14171 14367 93735 14172 14369 14362 13649 17246 22409 14186 14183 18595 26413 18121 11836 56717 17128 22422 55994 26397 20363 16878 16880 22413 23938 18709 16973 22412 12005 13712 14169 22416 12167 50772 19247 64654 14176 14388 19211 22411 14784 13543 11789 11651 21405 22417 17130 14173 22408 225724 14167 56636 22420 13645 29857 14365 22410 18596 14281 14174 14168 26399 26396 14178 12159 14179 353283 14175 22414 16974 p38 Mapk signaling pathway%WikiPathways_20260211%WP350%Mus musculus p38 Mapk signaling pathway 17164 14784 22030 15507 20416 26399 338372 19353 21812 17261 11909 20846 12912 26408 17346 26409 19766 73086 26416 13712 17187 15461 12540 15312 18783 26398 13198 19417 21808 13163 26401 17869 71609 GPCRs small ligand%WikiPathways_20260211%WP353%Mus musculus GPCRs small ligand 17773 12802 19216 19217 14739 19219 13610 13609 12801 21390 19204 14745 19222 19214 19218 13611 244701 19220 Fatty acid beta oxidation streamlined %WikiPathways_20260211%WP3588%Mus musculus Fatty acid beta oxidation streamlined 14079 97212 12896 11364 231086 15107 14077 13177 11370 433256 225579 11363 14081 57279 216739 12894 14080 12895 12491 12140 50790 11409 67460 110446 11770 93747 74205 26457 26459 26458 26569 26568 ApoE and miR 146 in inflammation and atherosclerosis%WikiPathways_20260211%WP3592%Mus musculus ApoE and miR 146 in inflammation and atherosclerosis 18034 11816 19697 387164 20375 16179 21898 22034 24088 Tyrobp causal network in microglia%WikiPathways_20260211%WP3625%Mus musculus Tyrobp causal network in microglia 27060 99586 67742 16164 14775 16409 668218 76448 80719 66824 105855 20514 338355 67963 66102 22177 15284 12504 239273 20540 245945 54519 12262 16414 216991 217203 12332 20850 56501 20111 20750 208647 12193 12399 56193 224109 17095 16950 12266 17970 238875 12493 21812 330217 12523 16411 78416 15163 16154 16923 231162 21938 50778 16173 57442 108735 17132 218454 Microglia pathogen phagocytosis pathway%WikiPathways_20260211%WP3626%Mus musculus Microglia pathogen phagocytosis pathway 15162 12259 22177 20963 18708 83382 58217 14127 14129 16409 83433 58218 16414 17096 15170 234779 16797 19353 19354 170758 22324 22325 57257 105855 11867 17972 17970 17969 13058 13057 12260 12262 30955 18706 18707 74769 18709 225326 18704 104709 18710 Lung fibrosis%WikiPathways_20260211%WP3632%Mus musculus Lung fibrosis 269400 20310 20750 224897 14164 20303 17131 14219 74108 20296 20482 21926 20387 16193 13614 13717 12985 23892 109620 21752 17257 20309 108689 12310 21802 16163 16176 12771 20304 18590 20292 50770 14173 17228 16191 13645 21857 16160 12162 18591 19288 18024 17395 14178 74180 12608 70086 15368 17390 15234 20389 12772 16189 12981 244548 18792 58909 20302 17750 16000 21803 Parkinson 39 s disease%WikiPathways_20260211%WP3638%Mus musculus Parkinson 39 s disease 107508 13195 13162 22223 50873 20617 21823 66725 68943 57320 64704 13063 14763 18951 67847 22187 22201 74153 22195 56791 140499 67128 22213 56228 20239 229521 12447 12448 29857 19094 26416 26415 12368 12371 12366 13063 12369 12367 11783 Ectodysplasin A signaling in hair follicle development%WikiPathways_20260211%WP3652%Mus musculus Ectodysplasin A signaling in hair follicle development 18033 19698 18034 19698 16994 18033 13608 19697 234130 66042 19697 171211 13380 14632 19206 20423 13607 13607 Novel Jun Dmp1 pathway%WikiPathways_20260211%WP3654%Mus musculus Novel Jun Dmp1 pathway 13406 11840 16653 16477 26413 12578 110157 17869 12567 12443 13555 19645 23871 26395 23872 16476 22059 17246 20130 18176 15461 11836 109880 26396 26417 14281 BMP signaling pathway in eyelid development%WikiPathways_20260211%WP3663%Mus musculus BMP signaling pathway in eyelid development 14165 14183 16324 21802 20423 12159 20377 17125 17129 17128 18741 56811 17300 14234 18128 26401 26420 16476 13649 26417 Hfe effect on hepcidin production%WikiPathways_20260211%WP3673%Mus musculus Hfe effect on hepcidin production 15216 71753 69585 84506 12161 17131 15901 Factors and pathways affecting insulin like growth factor IGF1 Akt signaling%WikiPathways_20260211%WP3675%Mus musculus Factors and pathways affecting insulin like growth factor IGF1 Akt signaling 17127 19017 56458 17126 19079 17700 21950 11651 16412 21937 433766 16367 18805 16202 228026 56717 72508 21926 19211 16001 16000 16011 11481 56717 18033 16006 16009 16010 16008 29817 16012 104771 IL 1 signaling pathway%WikiPathways_20260211%WP37%Mus musculus IL 1 signaling pathway 16180 19261 67245 16179 108960 26413 266632 53859 18035 26395 12675 26409 19697 16176 16175 22034 16177 16181 73914 16175 26417 12333 266632 68652 18803 18762 66513 18033 12336 18036 16178 19247 26419 12362 18412 230233 16176 54473 11651 17874 IL 3 signaling pathway%WikiPathways_20260211%WP373%Mus musculus IL 3 signaling pathway 16187 20846 110157 20850 14128 20525 56461 12402 15170 11909 20416 23939 16452 19303 22631 22330 20852 14388 21682 54721 17179 26413 14083 18707 14461 18708 17096 12015 12125 14784 12983 20662 11908 22324 12649 12928 16451 20848 18750 15901 14694 26419 14389 20851 18747 12169 16818 54401 26417 13429 11799 26416 16188 19052 11651 18033 58988 56637 21938 12043 20375 18751 14460 17532 16653 17395 19247 12912 109905 19401 20963 20779 18706 12028 17164 12700 18709 26420 15507 16331 12929 14159 15461 19354 107746 20344 606496 56458 18479 216233 20181 26395 15162 17390 12702 19353 12048 12540 14360 Prostaglandin synthesis and regulation%WikiPathways_20260211%WP374%Mus musculus Prostaglandin synthesis and regulation 13617 19225 13618 19223 20194 19109 15446 20200 11745 21391 11752 19222 11747 15483 18783 19224 19215 16952 19214 13070 11746 19216 15484 19219 19220 11749 22287 19217 19218 12306 13614 Myometrial relaxation and contraction pathways%WikiPathways_20260211%WP385%Mus musculus Myometrial relaxation and contraction pathways 51801 16012 64337 50782 18762 224129 20190 53313 11911 19088 18752 210044 18754 16011 14772 14695 14704 18768 14281 14773 18430 228785 14701 19735 14702 50779 16476 104111 14708 18749 12915 54409 11536 12310 11514 432530 216869 11908 18125 56533 18755 20191 64214 54401 16193 26385 12909 381489 12797 22629 12325 24012 17896 50778 18751 14745 56089 108058 18761 18127 109624 14873 12918 18750 22631 19087 14693 66066 18430 16010 20192 67865 104418 19737 11938 16008 58175 14682 14697 22627 18429 19084 19739 55948 11513 107503 234779 16176 14707 11535 19734 16440 18760 11465 14709 140498 14696 19085 56470 11461 53419 14391 18753 20683 14390 11512 14915 16438 12323 12921 19773 238871 23872 11910 104110 18799 19736 51791 20541 14916 109689 14609 22628 12297 12778 16006 18769 18578 14699 18767 22630 12913 11464 16009 18803 14683 17133 12315 11909 14706 11515 11459 14688 17906 50780 16439 18797 12322 18033 12912 60596 Dysregulated miRNA targeting in insulin PI3K AKT signaling%WikiPathways_20260211%WP3855%Mus musculus Dysregulated miRNA targeting in insulin PI3K AKT signaling 12825 14252 12843 12444 56717 53867 20662 12703 14104 107476 12125 26987 19108 12929 12827 26417 18710 53413 12043 12015 18708 12842 19744 12576 19087 110157 Wnt signaling in kidney disease%WikiPathways_20260211%WP3857%Mus musculus Wnt signaling in kidney disease 216799 11848 12387 16348 16973 228357 22408 22409 22410 22421 93735 22420 22418 22414 22411 22417 22416 22419 22412 22413 22415 22422 14362 14370 14366 57265 14369 14371 14367 14368 14365 13543 13544 13542 26420 26414 26419 56637 12005 17311 93687 11789 12234 Triacylglyceride synthesis%WikiPathways_20260211%WP386%Mus musculus Triacylglyceride synthesis 15450 14555 67512 14732 66853 67800 228061 16890 16956 233549 52123 68393 68262 50784 14712 67717 13350 14933 67916 14626 19012 55979 28169 Robo4 and VEGF signaling pathways crosstalk%WikiPathways_20260211%WP3864%Mus musculus Robo4 and VEGF signaling pathways crosstalk 74144 20563 16542 19353 22339 20779 IL 6 signaling pathway%WikiPathways_20260211%WP387%Mus musculus IL 6 signaling pathway 269643 56458 16194 18708 26395 19229 14159 235542 20848 12371 14388 26931 107951 18709 17977 17164 56637 12702 26399 12367 20416 20850 19053 12608 16193 20662 13867 16195 229317 14281 13866 26416 19052 12015 73699 19303 20846 16476 12229 14360 26413 14784 26409 433759 12569 19247 11651 16451 20393 21405 16331 11835 18033 13163 110157 26419 72508 54721 17762 15461 14083 26407 71978 21939 20112 14191 26417 18803 19645 72930 22324 21682 20851 16332 15507 13685 14389 26396 21770 19353 15519 328572 16452 54601 226849 51792 26398 12169 13684 225849 18099 12914 18753 110854 15162 56484 12568 17096 26932 ACE inhibitor pathway%WikiPathways_20260211%WP396%Mus musculus ACE inhibitor pathway 11421 16644 11609 11607 19702 19701 18127 11606 12062 mir 193a and MVP in colon cancer metastasis%WikiPathways_20260211%WP3979%Mus musculus mir 193a and MVP in colon cancer metastasis 27041 53872 78388 17869 12443 12444 miR 127 in mesendoderm differentiation%WikiPathways_20260211%WP3991%Mus musculus miR 127 in mesendoderm differentiation 320202 387146 11477 12627 17126 18119 11480 17128 15376 20997 21331 Mitochondrial long chain fatty acid beta oxidation%WikiPathways_20260211%WP401%Mus musculus Mitochondrial long chain fatty acid beta oxidation 50790 20280 12896 74147 14081 13177 11409 97212 12894 74205 11363 11364 11370 15107 57279 111175 Wnt signaling%WikiPathways_20260211%WP403%Mus musculus Wnt signaling 13544 11848 19353 18792 18751 18755 14296 56637 11789 22416 14365 26420 27373 12443 16835 14370 18760 22421 22411 22408 18750 16476 93897 14369 26931 22419 12387 22413 18754 22414 20379 18752 18472 13543 22420 12445 22418 14362 93735 14368 22417 26932 22415 12005 22410 18761 14367 22422 13542 18759 22409 14283 26414 17869 18762 12444 14371 30050 18753 57265 Kit receptor signaling pathway%WikiPathways_20260211%WP407%Mus musculus Kit receptor signaling pathway 14786 18708 18709 20416 12983 14784 54607 67296 56468 12700 67300 12928 20779 74055 16452 71520 19273 56792 18750 18803 20846 20850 20851 30955 23921 14783 11651 21682 17096 13448 15170 19247 13857 20111 17342 26413 11350 16331 14191 15162 22612 218397 14159 12929 12402 12703 22324 22325 17179 12015 20662 328572 14360 18751 15461 110157 114716 114715 58194 208650 21933 12229 16590 17311 26395 20848 17475 GPCRs other%WikiPathways_20260211%WP41%Mus musculus GPCRs other 319757 12614 18343 81014 14608 18329 259009 15550 12311 56696 18356 171469 80978 170732 113858 18315 113863 69296 11542 13617 107934 113845 18323 18387 22312 57260 213527 18321 18354 81011 18350 11554 14371 218066 78249 18344 81016 18322 113859 18390 257890 113853 66786 113846 18324 18361 18359 13489 233670 80910 259044 14367 53883 14816 18363 113849 258923 113864 58182 11539 76206 113862 27216 14788 259007 18316 258702 18352 18372 21338 18349 12801 258703 18241 17202 11555 81015 80290 64378 20609 64379 18332 26364 18317 113851 13488 12777 58861 18310 113854 18330 15552 14369 258435 18362 14766 23890 113855 13349 81013 22311 20132 18341 18389 18373 18357 13609 259115 14739 57265 13492 113856 110326 24112 54393 81012 113860 258153 18328 12374 22296 258859 208188 404316 113857 81010 18347 18331 18345 81017 22313 18351 258706 22354 113850 18358 113848 14362 113852 113847 258343 29848 170648 258326 258826 113865 244701 94226 22297 23832 71111 18346 12775 18307 Oxidative stress response%WikiPathways_20260211%WP412%Mus musculus Oxidative stress response 394436 26462 14281 13057 17161 20683 26416 26414 13076 14872 18032 12359 14782 20657 14778 14629 17748 18104 50493 20656 15368 16477 14391 14775 18033 56615 20655 56551 G1 to S cell cycle control%WikiPathways_20260211%WP413%Mus musculus G1 to S cell cycle control 12567 12571 12443 12444 12445 12575 12576 12572 66671 13555 242705 13557 19650 19645 104394 13559 50496 21781 211586 12566 12447 12448 18974 18973 12530 22390 268930 12534 12544 19891 68240 68275 17216 17215 17217 17218 17219 17220 18392 18393 50793 26428 26429 56452 19075 19076 18969 18538 22059 13197 17246 12580 12579 12581 12578 12427 11920 12577 12452 17869 17420 Distal convoluted tubule 1 DCT1 cell%WikiPathways_20260211%WP4183%Mus musculus Distal convoluted tubule 1 DCT1 cell 16517 69847 12283 53416 232341 56365 20497 Ethanol metabolism resulting in production of ROS by CYP2E1%WikiPathways_20260211%WP4265%Mus musculus Ethanol metabolism resulting in production of ROS by CYP2E1 26419 13106 20683 26396 17133 17134 26395 17135 18024 18753 Nuclear receptors in lipid metabolism and toxicity%WikiPathways_20260211%WP431%Mus musculus Nuclear receptors in lipid metabolism and toxicity 11303 19013 12780 19016 18171 27413 19401 13124 13077 27409 11307 13082 12355 22337 76408 13088 13122 218772 13115 19411 13120 18670 13081 22259 18671 20186 13106 26874 19015 69050 19299 Eicosanoid lipid synthesis map%WikiPathways_20260211%WP4335%Mus musculus Eicosanoid lipid synthesis map 18784 53357 18783 211429 74451 19225 64292 19215 11689 TCA cycle%WikiPathways_20260211%WP434%Mus musculus TCA cycle 18563 18597 68263 27273 170718 27402 235339 13382 66945 17449 20917 11429 381511 56451 78920 18604 15929 66052 228026 66925 67680 12974 20916 67834 236900 269951 18293 18598 382051 14194 17448 Sphingolipid metabolism overview%WikiPathways_20260211%WP4344%Mus musculus Sphingolipid metabolism overview 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 67260 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 Glycerolipids and glycerophospholipids%WikiPathways_20260211%WP4345%Mus musculus Glycerolipids and glycerophospholipids 14732 19012 66586 212862 68671 74596 320951 13350 27388 66853 18805 104418 19210 18618 68262 52858 12651 13026 75320 102247 67800 18778 116939 Cholesterol metabolism with Bloch and Kandutsch Russell pathways%WikiPathways_20260211%WP4346%Mus musculus Cholesterol metabolism with Bloch and Kandutsch Russell pathways 20787 110446 11303 12642 15357 13122 22259 20652 14104 13360 235293 13595 73166 13116 104086 223920 110460 208715 15360 17855 68603 192156 20775 319554 320581 14137 14593 110196 16987 74754 22260 11307 218203 20788 14081 74205 50790 26897 171210 18194 74754 54326 12686 83603 68801 76267 56473 20249 20250 13121 73166 66234 98386 15490 18194 Eicosanoid metabolism via cyclooxygenases COX %WikiPathways_20260211%WP4347%Mus musculus Eicosanoid metabolism via cyclooxygenases COX 19223 21391 15446 18784 19015 69050 53357 18783 211429 19224 19225 64292 19215 11677 67103 77219 13117 277753 13118 64385 72054 11430 93732 80911 113868 74147 19222 66469 19220 19214 14764 21390 19224 Eicosanoid metabolism via lipoxygenases LOX %WikiPathways_20260211%WP4348%Mus musculus Eicosanoid metabolism via lipoxygenases LOX 13117 16993 211666 625249 72054 14775 11689 66447 11687 15446 13850 17001 277753 13118 64385 72054 11430 93732 80911 74147 113868 14598 23887 13479 319446 11684 67103 77219 Eicosanoid metabolism via cytochrome P450 monooxygenases%WikiPathways_20260211%WP4349%Mus musculus Eicosanoid metabolism via cytochrome P450 monooxygenases 13850 13117 277753 13118 64385 72054 13095 13096 13097 13098 13099 226143 404195 72082 13109 19013 One carbon metabolism%WikiPathways_20260211%WP435%Mus musculus One carbon metabolism 108156 69606 13433 14450 13436 13361 11720 12116 108645 108147 14317 21452 17768 434437 108037 238505 53320 77683 269378 20425 270685 13435 17769 210009 110147 107747 74340 22171 107885 Omega 3 omega 6 fatty acid synthesis%WikiPathways_20260211%WP4350%Mus musculus Omega 3 omega 6 fatty acid synthesis 56473 14081 74205 50790 54326 68801 76267 11430 80911 26897 171210 74205 50790 18784 53357 18783 211429 Omega 9 fatty acid synthesis%WikiPathways_20260211%WP4351%Mus musculus Omega 9 fatty acid synthesis 76267 14081 14104 74205 50790 54326 68801 170439 12686 54325 20250 56473 26897 171210 PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine%WikiPathways_20260211%WP4398%Mus musculus PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine 18595 16765 Matrix metalloproteinases%WikiPathways_20260211%WP441%Mus musculus Matrix metalloproteinases 26561 234911 17390 17385 17388 240047 17395 17392 118453 21858 17393 17384 23948 58223 12215 17381 17389 21411 17387 214766 30800 21857 17394 17386 21859 17391 21926 83995 110595 Oxidative stress and redox pathway%WikiPathways_20260211%WP4466%Mus musculus Oxidative stress and redox pathway 14780 18477 22166 50868 332309 12505 14854 75475 20511 26570 20371 14873 14870 14775 20514 433899 625249 14776 14381 14664 14629 18024 11689 18181 14871 14857 14782 12411 15926 56615 14863 14660 14630 110175 14778 75512 67305 69590 269951 14380 110208 14872 103140 14862 14864 14865 14866 14867 68312 14858 14859 14860 14869 68214 211666 66447 54486 76263 23887 71522 207182 14598 12780 27416 66988 16790 104245 28248 24059 12477 13058 13057 19353 17972 17969 17970 21672 11757 53381 54683 11758 320769 19224 19225 20201 20202 20655 20656 20657 50493 26462 232223 Adipogenesis genes%WikiPathways_20260211%WP447%Mus musculus Adipogenesis genes 20378 27217 22410 20185 13591 13865 14362 16334 16370 22408 116939 20787 16369 15251 20183 20181 12606 18196 20683 12153 12608 12387 17873 21405 230709 13819 228775 17977 268903 20602 11606 16846 14705 20528 16905 12156 19883 13555 12159 14463 14560 16878 13198 16890 12912 19223 16880 13197 13542 14102 52637 93691 11622 17319 57264 67512 20851 12804 18534 13046 20847 66277 14234 19651 18787 12224 17260 19645 20848 17984 110075 14461 17127 11537 232174 20852 16193 20745 14599 21803 11450 15903 22419 13654 59027 14462 56758 11604 11520 22160 20846 19650 19016 97064 22259 12609 104394 14815 21926 23849 19013 20379 16956 64898 17978 14245 13386 18413 16195 19017 16333 12702 20249 13082 17258 384783 103968 19401 105980076 17259 19015 69050 11770 12703 22227 16000 56458 20850 64899 15361 17261 19116 74551 16367 21887 Circulating monocytes and cardiac macrophages in diastolic dysfunction%WikiPathways_20260211%WP4474%Mus musculus Circulating monocytes and cardiac macrophages in diastolic dysfunction 20296 16153 20750 12772 Complement and coagulation cascades%WikiPathways_20260211%WP449%Mus musculus Complement and coagulation cascades 19123 12259 16644 14058 17174 12258 21788 22371 18792 232345 12946 12269 14069 58992 12509 21824 18815 50908 12266 12628 109828 11905 13136 12267 14962 14061 18787 14066 13137 109821 14068 14067 69379 18793 18816 18791 12263 56373 17194 15139 12274 17175 50909 12260 14071 14062 12268 12630 12273 12061 11537 15160 19128 17221 12902 12262 268591 14060 16621 110135 12279 Elongation of very long chain fatty acids%WikiPathways_20260211%WP4491%Mus musculus Elongation of very long chain fatty acids 14104 68801 12686 54325 74559 170439 83603 54326 56473 170439 68801 76267 12686 30049 20249 20250 329065 56473 54325 74559 76267 IL 2 signaling pathway%WikiPathways_20260211%WP450%Mus musculus IL 2 signaling pathway 16183 20851 16453 12928 22324 20846 12912 23872 17096 11651 21752 12700 23871 19247 14694 12703 20850 230126 18707 13684 12402 20844 16818 16185 16184 110157 12508 15894 56717 27979 16451 14784 26395 20963 12043 17346 18708 12702 15962 74769 16432 26419 14389 20848 12675 19229 16452 22608 18709 14815 18795 19697 18706 16186 56324 18033 18762 26396 64685 14360 16653 26420 17164 26413 72508 30955 12929 20662 26416 15519 26417 16367 56484 15170 20416 384783 Osteoclast signaling%WikiPathways_20260211%WP454%Mus musculus Osteoclast signaling 18383 18591 194352 21943 11433 15977 20544 66290 21934 15975 16416 13038 238377 20750 GPCRs class B secretin like%WikiPathways_20260211%WP456%Mus musculus GPCRs class B secretin like 12311 54598 12921 12922 381853 93896 14652 14527 14602 213527 19228 11517 319229 22354 22355 26364 13733 330814 99633 319387 170757 237175 Inflammatory response pathway%WikiPathways_20260211%WP458%Mus musculus Inflammatory response pathway 12524 21938 16779 15978 21827 22370 16183 16190 16185 16818 16777 16186 16189 12825 21939 12842 16782 12843 12487 21947 21937 14268 12519 16184 226519 22637 16776 21825 16191 16192 Blood clotting cascade%WikiPathways_20260211%WP460%Mus musculus Blood clotting cascade 14058 14061 58992 99571 18815 14071 14070 18792 110135 22371 14067 14060 109821 18816 18791 18788 18787 14069 14068 14161 Lipids measured in liver metastasis from breast cancer%WikiPathways_20260211%WP4627%Mus musculus Lipids measured in liver metastasis from breast cancer 79235 Sphingolipid metabolism integrated pathway %WikiPathways_20260211%WP4690%Mus musculus Sphingolipid metabolism integrated pathway 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 71949 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 76893 67260 Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle%WikiPathways_20260211%WP4763%Mus musculus Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle 19017 56637 21425 19017 21425 T cell receptor signaling pathway%WikiPathways_20260211%WP480%Mus musculus T cell receptor signaling pathway 72699 218397 12481 22325 26411 12501 22376 16453 12503 78473 108723 20662 94176 56233 14389 12387 12929 19395 14360 27387 20851 18003 16428 13800 14281 20218 18709 22323 72349 71520 12525 20663 18019 12507 23853 54353 12928 17096 11431 13430 26431 18761 19303 15170 14784 16797 16818 20963 26417 545902 12700 18708 11308 16476 101540 13383 77647 18479 53416 19271 12488 12504 19247 20850 12500 242687 11857 17975 23939 23880 26396 22165 24055 192656 54126 104248 73341 20779 16438 14083 22248 22145 17829 11350 26558 12608 14357 18803 20416 26413 19248 20846 230126 57257 329693 16923 16822 26395 109905 208650 77799 240754 17973 26401 22324 12402 12914 22154 545622 109880 19200 20491 74039 19264 22637 13169 19229 12502 14026 215280 19260 19354 27371 12912 54390 12540 19056 94212 11651 17444 12042 107746 GDNF RET signaling axis%WikiPathways_20260211%WP4820%Mus musculus GDNF RET signaling axis 24063 17300 20671 14048 20666 18504 58198 11609 14234 14573 14462 329628 268902 12159 16869 20563 23892 19713 14585 14634 67042 72938 12387 Peroxiredoxin 2 induced ovarian failure%WikiPathways_20260211%WP4835%Mus musculus Peroxiredoxin 2 induced ovarian failure 12028 13063 13070 15494 12367 20845 21672 Alpha 6 beta 4 integrin signaling pathway%WikiPathways_20260211%WP488%Mus musculus Alpha 6 beta 4 integrin signaling pathway 11848 20166 192897 14360 23844 14083 16403 16785 22352 229933 14784 13518 59079 13866 18708 18709 18710 18706 74769 30955 18707 12821 20416 19882 55948 16772 16777 226519 16776 16779 16773 16774 16780 16782 18479 19353 18810 12476 384783 16367 13649 11835 22062 11350 54401 22627 22629 22631 22612 109620 17295 13685 13684 16418 18208 11651 12367 12015 18750 56717 18753 17393 20779 17126 17127 12575 Mapk signaling pathway%WikiPathways_20260211%WP493%Mus musculus Mapk signaling pathway 21813 19252 17165 13712 170706 26940 19418 12929 216869 110651 26403 16765 218397 12369 320139 381921 22059 16177 12368 13649 11652 21926 13198 12928 69253 15370 14175 12475 11911 14103 65964 13197 21812 19055 12367 68652 18752 26409 56274 12370 109689 19419 14784 269275 16151 109880 26420 20807 26415 53859 26565 26401 19279 18596 26396 21809 19259 16653 19042 16175 12531 14281 18755 78405 12371 17451 16150 15507 11479 11651 53608 19059 50932 12540 110157 50772 23939 26408 18753 18176 18751 26414 11909 26404 13645 18099 16476 26407 225028 26413 71751 21808 193740 18784 216965 26395 63953 18049 19043 17164 14828 67603 30957 319520 224105 26398 225724 240672 19060 109905 19058 26921 17869 66513 15481 21803 13163 18033 26417 233046 17762 26399 18762 103988 18015 23797 19056 19354 12362 12064 18479 26419 16178 18747 26416 22030 26400 19057 215449 29857 22034 18211 26410 17532 16176 20663 235584 114713 14673 12366 19353 17260 26411 18591 23938 14102 192176 17187 16478 Deregulation of renin angiotensin system by SARS CoV infection%WikiPathways_20260211%WP4965%Mus musculus Deregulation of renin angiotensin system by SARS CoV infection 11607 70008 11421 11609 Hypoxia dependent self renewal of myoblasts%WikiPathways_20260211%WP5023%Mus musculus Hypoxia dependent self renewal of myoblasts 15213 15205 15214 17877 17879 17927 12575 18509 17928 18128 56458 15251 22027 Hypoxia dependent proliferation of myoblasts%WikiPathways_20260211%WP5024%Mus musculus Hypoxia dependent proliferation of myoblasts 22339 17700 433766 17927 22084 15234 67731 17877 64930 11651 17127 16000 74747 19744 14164 56717 17126 17928 12310 Hypoxia dependent differentiation of myoblasts%WikiPathways_20260211%WP5025%Mus musculus Hypoxia dependent differentiation of myoblasts 12575 26416 17877 17878 18128 112405 12576 319594 15251 17879 17928 20893 22339 17928 Na K ATPase Src signaling%WikiPathways_20260211%WP5051%Mus musculus Na K ATPase Src signaling 230661 19354 56637 11928 11798 22165 14360 20662 109905 12391 16542 12015 170758 20363 14784 12043 110157 17295 13649 26420 320207 18479 20811 16202 18481 11796 107746 50772 11797 12387 243659 330662 20418 11836 12928 26396 26397 30955 12371 15461 56717 13067 109880 26413 12444 13063 14083 22324 23797 241656 51789 18595 12445 11931 23938 215449 12143 14254 26419 19353 20459 20779 224105 83813 26399 214230 225724 12929 12390 12389 20416 70584 11783 23939 11651 74769 18707 13866 18596 109880 26395 12443 16001 18706 15162 19211 13712 75669 12367 12927 11652 18708 18709 16476 29857 14191 Burn wound healing%WikiPathways_20260211%WP5056%Mus musculus Burn wound healing 22339 18127 16772 12842 21926 15200 21803 18613 73122 18126 14248 11459 14609 56189 216799 Nuclear Receptors%WikiPathways_20260211%WP509%Mus musculus Nuclear Receptors 20182 26379 218772 14815 26424 22026 19411 18227 11835 18667 21907 11819 22337 26423 21834 353187 21833 19885 20183 19883 19015 69050 13865 19016 26563 11614 15370 20181 13983 22260 22259 19401 13982 18171 13864 19013 15378 26380 12355 ID signaling pathway%WikiPathways_20260211%WP512%Mus musculus ID signaling pathway 15901 15902 15903 15904 19645 19651 19650 21423 17927 12566 12428 12447 13712 13714 13713 19185 15205 18507 18504 18510 17877 17878 17928 21406 20787 17681 12156 12168 22339 14254 16542 17125 17128 17129 11910 17127 21815 11482 16818 16001 16000 16367 12387 21752 18033 19697 12161 21947 18049 13645 21416 Fibrin complement receptor 3 signaling pathway%WikiPathways_20260211%WP5128%Mus musculus Fibrin complement receptor 3 signaling pathway 11651 16193 16150 18706 18815 18033 20963 19696 142980 208650 17874 15977 11848 16179 18791 15945 54354 117149 22034 106759 12475 22177 14127 330122 18815 266632 17087 16803 21898 20779 225471 54131 16409 16414 21926 20296 12675 16151 14161 108960 16160 18126 110135 99571 19697 Oxylipins pathways%WikiPathways_20260211%WP5140%Mus musculus Oxylipins pathways 15446 13850 66469 19215 64292 19223 21391 11689 11688 11684 11687 76267 56473 19225 17001 16993 14598 13479 14775 12408 54486 13850 Proteasome degradation%WikiPathways_20260211%WP519%Mus musculus Proteasome degradation 19171 22190 319170 93841 19166 15007 19186 19170 26442 15007 66997 67151 19184 22210 16913 17463 19172 66105 69077 22201 103963 19182 51788 26445 16912 15978 19167 22223 15007 53380 15007 22123 23997 56550 20014 15270 66413 26444 26440 74153 19175 26443 19173 19192 19179 66998 216080 17999 67089 23996 19185 22187 15007 26441 19188 19177 19181 15007 26446 21762 57296 19184 Biogenic amine synthesis%WikiPathways_20260211%WP522%Mus musculus Biogenic amine synthesis 14417 13195 21990 15186 13166 21823 18948 11423 12846 18478 12647 11298 14415 17161 107626 Regulation of actin cytoskeleton%WikiPathways_20260211%WP523%Mus musculus Regulation of actin cytoskeleton 56419 108083 26413 12671 18719 227753 231637 18479 18643 225326 14176 18590 14163 320207 20663 108100 29875 22330 14165 16801 54126 14674 19684 77579 329165 243764 12669 240752 14180 13649 13800 237860 232906 170758 242687 241656 227733 17532 26395 16885 12061 14178 22349 14673 50884 14169 11461 18709 224105 14186 14174 213788 14167 12540 19241 18705 13645 226970 12927 107589 245857 14175 18708 18481 330662 12672 12632 12475 18596 67771 18706 14083 80857 14171 11848 20544 14184 18704 64654 74769 12062 19878 14170 14172 18718 56636 18176 14173 18710 22350 19877 11465 67112 14268 80903 30955 73341 17901 19353 109880 17931 22376 66922 75669 20130 11789 66985 18595 16653 14168 18720 83767 70584 109711 14701 13367 18717 20662 17698 12928 16334 109700 110157 12988 117150 26417 18591 76884 17897 26396 19303 19354 16333 14183 18707 50772 214230 23805 216963 12631 17451 14177 14164 14061 14062 14182 14166 14179 22324 225724 101314 Lac Phe pathway%WikiPathways_20260211%WP5240%Mus musculus Lac Phe pathway 27416 66054 Comprehensive IL 17A signaling%WikiPathways_20260211%WP5242%Mus musculus Comprehensive IL 17A signaling 20302 20311 14268 20304 12540 11459 14825 20315 20303 11475 16000 24099 14118 15511 20613 17345 17220 11522 15289 12842 18591 15132 20656 269437 20311 22059 18749 11749 18792 16176 19225 17392 20846 14219 19353 56717 107589 14701 320011 16193 17218 12367 18590 19325 66870 266692 12266 76709 67089 18793 19697 18938 104184 20583 20309 11848 18481 16176 109828 17387 56378 14432 66922 67771 11927 12282 269823 11600 17395 20310 100503605 15129 13649 19704 230709 18393 19646 12540 19353 18793 56045 12301 22589 18392 18792 18148 50927 18538 19290 98415 18412 67443 12043 17130 17126 56208 20848 66734 17131 225326 17217 17219 17216 21803 17215 56717 20315 17126 17127 11651 20613 20583 21872 16452 Dravet syndrome Scn1a A1783V point mutation model%WikiPathways_20260211%WP5298%Mus musculus Dravet syndrome Scn1a A1783V point mutation model 20265 20501 19049 13823 20511 12298 12297 16832 20512 14580 16828 55936 17161 12295 16542 12286 19417 14810 12287 109731 12294 21926 20912 14802 14660 72821 18706 279653 56716 54393 14415 18033 14400 14396 242425 14811 53623 14402 235281 55943 14645 20910 20266 56717 399548 109270 20269 14799 78757 16490 12322 20265 72446 244059 227743 19094 14168 11651 14417 108069 228960 14394 57138 16524 16519 16513 20525 20503 76257 20527 232333 14395 14397 72961 Globo series sphingolipid metabolism%WikiPathways_20260211%WP5305%Mus musculus Globo series sphingolipid metabolism 14344 227671 93961 26879 Wnt signaling pathway%WikiPathways_20260211%WP539%Mus musculus Wnt signaling pathway 22218 22413 99470 14200 21374 93840 11789 57265 13728 77578 22415 12387 93687 13543 13542 14368 26419 23859 12005 14371 23988 12322 109689 26413 22418 14362 58198 22408 212398 13385 11651 16842 93960 27373 26417 19099 208846 104318 17127 13017 26420 11848 18099 26564 20319 20664 19353 20377 12443 14367 216869 12534 13132 22417 140577 56637 13380 17863 12995 26992 16973 14366 319478 20682 12532 12393 12234 18504 21413 16971 12550 26409 56505 108058 59004 16974 26965 75826 13000 14369 22416 16480 17128 22421 14370 15258 12323 12961 18751 13383 26423 16476 21418 67087 18750 13001 328572 13016 14296 21402 110157 12325 12006 76281 21423 13544 17755 19052 Synthesis and degradation of ketone bodies%WikiPathways_20260211%WP543%Mus musculus Synthesis and degradation of ketone bodies 15356 110446 15360 67041 71911 Exercise induced circadian regulation%WikiPathways_20260211%WP544%Mus musculus Exercise induced circadian regulation 22229 30960 11865 20610 18627 12608 22763 18701 14864 75062 319187 12952 22057 54375 19290 52331 64209 19053 12741 353187 14373 13690 12953 12753 17878 50884 15502 217166 12417 27057 53412 14011 216558 18626 238988 22153 23994 14869 19317 15481 68652 26441 14585 14998 16601 12226 19663 22218 319554 Steroid biosynthesis%WikiPathways_20260211%WP55%Mus musculus Steroid biosynthesis 15497 13074 15493 15496 15492 15495 15494 15486 15487 15485 14060 15488 15490 Calcium regulation in cardiac cells%WikiPathways_20260211%WP553%Mus musculus Calcium regulation in cardiac cells 12295 12325 20191 50779 104110 14702 432530 12322 18751 12290 64337 50778 67972 14678 53313 320707 14613 18797 11549 14696 18821 58175 18749 20190 12326 224129 18768 216869 67865 11550 11554 51791 12292 12672 243764 12288 14615 16500 210044 14609 16439 19085 12289 108058 14695 12286 16519 19737 54401 14697 16521 22631 22629 14611 16438 11941 14620 14621 55948 18760 14701 14682 66066 18753 14708 14623 14679 18754 64214 24012 14773 14709 18767 20192 16440 11514 12669 56470 11548 12315 14225 14618 14616 56533 12372 104111 22627 11749 14672 14707 11515 19734 20541 22630 11513 14687 11556 14622 12317 50782 14699 18762 19084 14693 18769 19736 18755 19088 18761 14704 18750 118454 14688 12373 14681 110893 18821 11938 19735 109689 14683 14619 12287 14677 12671 19739 213788 12323 14612 14706 22628 52163 12297 18752 11512 14772 19087 11555 50780 14617 26385 27222 11931 11936 11932 11933 Eukaryotic transcription initiation%WikiPathways_20260211%WP567%Mus musculus Eukaryotic transcription initiation 235459 24074 13872 68705 229906 23894 67710 102216272 108143 20022 68153 74197 245841 67065 20019 209357 99730 26939 20016 21343 66464 16202 20018 17749 20020 69920 14884 78929 66671 12572 20017 226182 67005 66420 21374 70428 231329 14885 17420 20021 13871 Signal transduction of S1P receptor%WikiPathways_20260211%WP57%Mus musculus Signal transduction of S1P receptor 26417 18705 13610 26413 26934 13609 20698 14677 23939 18797 11652 54447 20598 14678 94226 29857 23797 11651 50772 56632 14679 14739 Monoamine GPCRs%WikiPathways_20260211%WP570%Mus musculus Monoamine GPCRs 15465 11553 15562 13490 15466 12671 11549 13492 15564 13491 11556 11548 243764 15565 15552 12669 15566 12672 13489 213788 11551 15558 15557 13488 15563 11554 11552 15560 15559 15550 11550 15551 11555 FAS pathway and stress induction of HSP regulation%WikiPathways_20260211%WP571%Mus musculus FAS pathway and stress induction of HSP regulation 20740 16175 14084 12369 15507 192656 13368 18479 11783 13163 17164 12370 11545 13347 11857 14103 14082 19645 26419 16476 102626 26398 12368 224105 26409 16906 16907 12371 12633 12043 26401 12367 21926 19090 16905 19249 14102 EGFR1 signaling pathway%WikiPathways_20260211%WP572%Mus musculus EGFR1 signaling pathway 13645 110157 15461 18176 16653 56392 18708 26405 50915 14784 14783 26406 20662 14786 18709 20416 18710 18706 74769 18707 30955 14388 14389 16451 20846 16452 20848 20850 20847 20851 26395 18750 26401 18762 18760 18759 18751 26396 26397 23938 26407 22324 57257 22325 23939 26413 26417 13714 13712 26419 26400 19279 14609 54401 232341 13649 110310 16691 16667 16668 382523 107686 18810 19248 20779 12402 12928 12929 67184 19353 19229 12389 12390 17973 17974 18803 216963 19734 12703 12702 16332 271457 98910 11843 22687 19766 53859 19730 218397 20459 19084 15170 19247 22038 74155 13449 18738 80794 208650 18806 18805 13858 13860 15194 240752 56726 12988 194590 19765 64143 19707 51789 11308 20663 13429 20408 12540 24064 16478 14281 12606 17869 12608 23980 194655 20466 21815 433759 58194 20404 16476 20683 11651 19259 20617 20111 110651 20112 11771 73178 26365 13627 72993 216190 23942 13859 13854 215114 19727 26416 57783 245688 13196 20910 12388 109333 18479 27387 12927 12371 73086 17126 17127 11908 12912 56458 19303 13710 107435 12322 16396 11836 109904 234779 19252 Leptin insulin signaling overlap%WikiPathways_20260211%WP578%Mus musculus Leptin insulin signaling overlap 16452 18607 16847 12702 20848 18710 11651 216233 30955 16337 12703 16333 104418 16846 16367 384783 16369 16370 Integrin mediated cell adhesion%WikiPathways_20260211%WP6%Mus musculus Integrin mediated cell adhesion 16401 73647 109711 16202 14083 16416 16407 20662 22793 109905 16409 12928 16404 16421 12337 381924 20363 19877 16410 16400 22330 107746 16399 12338 19354 19303 214230 26395 12927 192897 320910 18607 12335 20779 330662 57257 109880 12390 16408 11836 268958 23830 16411 109700 14360 26414 12988 12391 212541 15461 23939 12389 16420 50772 20416 16412 12334 23797 26396 18709 104099 21961 12339 16402 213119 110157 22325 12540 23938 12336 16414 224105 26397 26413 20411 215449 26399 18481 16398 11652 12333 19353 19878 26431 22323 16403 18479 11651 14784 16419 241226 319480 54126 228785 70584 225724 29857 170758 21894 20418 miR 1 in cardiac development%WikiPathways_20260211%WP608%Mus musculus miR 1 in cardiac development 16508 54352 15111 Pentose phosphate pathway%WikiPathways_20260211%WP63%Mus musculus Pentose phosphate pathway 14381 66171 66646 21351 19895 21881 110208 Insulin signaling%WikiPathways_20260211%WP65%Mus musculus Insulin signaling 18710 210789 16369 16568 14252 20111 20913 20910 26414 19354 19246 110651 26408 11652 72508 26406 56458 20911 12402 13712 15461 13684 12702 13660 26419 19268 26412 104215 14281 22433 26396 19211 50932 20418 20912 16370 11845 26405 23921 26420 22084 110157 26397 18709 14251 73086 18642 18753 18704 16890 13685 53859 19159 20662 18751 225724 50915 26415 23938 16573 16476 14936 17913 107746 19353 19094 18707 50772 56637 14784 14388 18755 26417 170755 108079 18708 80794 58988 232493 75669 20909 27219 26921 56717 20614 399510 16332 23939 18761 208650 12703 14783 26407 11840 26409 26399 233071 22318 16367 26413 20416 12928 269180 26401 19341 16150 269881 225326 30955 259300 64930 20112 216148 18607 18706 11651 26400 80837 12331 29857 53608 18705 26395 67071 18759 19247 56437 71751 18762 74769 225028 338372 19744 19047 434233 26404 20807 56484 20619 20663 56613 18750 26398 18641 27357 20411 105787 26410 20393 228775 26403 26416 26411 13653 18605 16001 16337 20525 20528 Amino acid metabolism%WikiPathways_20260211%WP662%Mus musculus Amino acid metabolism 14782 15186 12411 20603 17449 14860 18746 11898 11754 107508 13382 18534 14661 15360 140483 13195 11364 14719 11992 27273 19125 78920 14085 74147 15109 105148 11668 320092 227095 234724 69719 212679 12116 12035 113868 58875 108682 18452 18597 22018 14630 11532 18242 242083 26876 17161 21823 231691 102436 14378 22375 16828 11522 14660 66945 23874 27053 18597 110695 246221 56451 15356 11529 18563 209027 18293 109900 14854 14194 107869 21990 17850 11846 17448 15926 18948 13166 11429 14645 104458 72039 18263 14317 56454 14718 12974 104112 22321 27402 56720 18416 66925 68738 227231 20810 15107 11847 Leptin and adiponectin%WikiPathways_20260211%WP683%Mus musculus Leptin and adiponectin 72674 105787 19079 16846 68465 107476 19082 16847 12894 11450 Wnt signaling pathway and pluripotency%WikiPathways_20260211%WP723%Mus musculus Wnt signaling pathway and pluripotency 22059 71978 18761 13543 73699 14362 22418 16974 269643 18751 22411 14369 13017 19053 19052 12914 13542 14366 21415 93735 14283 52432 14370 21413 26409 56637 14296 13016 22410 71887 17869 16835 22419 12387 22408 22411 22422 22416 12444 13544 17393 26420 22421 18044 18750 22414 16842 26931 72293 21410 14365 20674 18792 18755 18760 22413 30050 18472 19015 69050 18099 51792 21405 18752 18762 14368 57265 72930 12006 12445 14367 22417 71950 11789 26932 16476 328572 22412 16973 12388 22420 26414 18753 110854 18999 12443 12005 26934 22409 27373 22415 56805 93960 18754 14371 18759 15221 11848 12505 Glutathione and one carbon metabolism%WikiPathways_20260211%WP730%Mus musculus Glutathione and one carbon metabolism 16790 14381 23887 14775 12116 13433 210009 17769 14630 14782 14598 14854 14629 434437 74340 238505 108645 13435 218865 14598 14776 13436 11720 75475 15926 269378 20425 14778 108037 625249 12411 107869 Tryptophan metabolism%WikiPathways_20260211%WP79%Mus musculus Tryptophan metabolism 64385 70790 15930 13106 57751 270076 56752 15469 11669 19378 107626 13076 17246 18293 109731 11671 13195 15108 12359 22215 15107 13123 23923 110446 70789 71562 13078 11298 11761 74754 266645 13077 72082 22375 21743 13075 11668 320092 13110 107766 76507 93747 56720 13107 21990 Focal adhesion%WikiPathways_20260211%WP85%Mus musculus Focal adhesion 12826 230661 11465 18607 19354 56637 107589 53867 21828 22165 14360 20662 12831 16420 105083 109905 12391 12015 319480 170758 12815 16780 20363 14784 329278 12043 110157 227377 12333 15234 17295 13649 11848 16404 16409 12843 26420 320207 15891 18479 12832 20811 16202 94216 228785 18481 21827 16398 11796 16773 107746 18717 12824 12829 50772 13645 192897 16402 11797 16775 320910 381924 16416 19878 16776 243659 330662 12643 20418 213119 11836 12928 26396 26397 81877 170736 30955 16400 12842 16403 14205 109880 192176 26413 12444 71785 13367 17931 16410 14083 22330 16772 22371 12825 22324 23797 16411 241656 51789 16414 18595 12445 54635 23938 16399 215449 12143 14254 26419 19353 23928 19877 20459 21826 12540 16421 22793 20779 224105 18591 83813 20750 26399 214230 225724 12929 14268 11855 12814 16401 12390 12389 22370 16000 20416 109711 18654 70584 11852 18590 23939 11651 19303 74769 18707 13866 18596 109880 26395 226519 12443 16779 22340 21894 18706 16774 15162 19211 22341 16777 13712 19699 75669 12827 11461 16412 241226 16407 104099 22339 12834 16419 21825 16408 12927 11652 18708 18709 16782 22323 21923 17904 16476 29857 14191 21960 Toll like receptor signaling%WikiPathways_20260211%WP88%Mus musculus Toll like receptor signaling 24088 21898 117149 142980 17153 73914 266632 225471 17874 16179 19765 106759 108960 14082 22031 12367 12370 56489 11308 54131 56480 22026 26416 12675 68652 19106 22034 26399 16150 17121 16151 18033 18034 IL 4 signaling pathway%WikiPathways_20260211%WP93%Mus musculus IL 4 signaling pathway 18762 11651 18033 56468 16190 20852 18708 19094 72508 15170 16451 13712 26413 13449 19247 16453 17969 16818 20662 20850 15361 384783 20416 14083 14159 14360 16189 54721 16367 18707 218397 26417 26416 16164 20844 18753 12767 12914 20846 18759 12702 12015 16452 114774 20375 320129 328572 23871 75292 20779 18803 16331 11909 14784 12703 16186 18706 18709 19697 12402 12048}