KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB PDHX FH SUCLA2 MPC1 SUCLG2 HEL-S-133P SUCLG1 GPT DHTKD1 PCK2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260211%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN3 COMP MATN1 COL9A1 COL9A3 COL9A2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260211%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor ACTA2 MAPK10 COL1A1 MAPK9 MAPK8 TGFB1 STAT3 ENPP2 RHO LPA CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260211%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC4 TUBA2 PSMC1 STUB1 TUBA8 UBE2L6 PARK2 UBE2L3 HEL-S-89n TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD5 PSMD2 RNF19A TUBB1 PSMD3 PSMD1 GPR37 FBXW7 HEL-S-103 TUBB HEL-S-72p CASK SEPT5 TUBA4B TUBA4A TUBB2A CCNE1 PSMD10 PSMD12 PSMD11 HEL-S-91n TUBAL3 PSMD13 HSPA14 UBE2J2 UBE2J1 TUBA3E SNCA HSPA4 SIAH2 SIAH1 UBE2G1 HSPA2 UBE2G2 SNCAIP TUBB4B TUBB4A PSMC6 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260211%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation CRTC2 FLT1 INSR PDX1 PDGFA BRAF IGF1 FOXM1 TGFBR1 FOXO1 IGF1R INS RAB43 RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways RGS16 CAMK2A ADCY3 ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G CORIN GUCA2B GUCA2A RGS10 ACKR3 RGS11 RAMP1 ACKR5 ACTA2 ATF1 ATF2 MYLK2 HEL2 OXTR CRCP GABPB1 ETS2 SLC8A1 RXFP2 ACTG1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 IGFBP1 PRKCH IGFBP5 PRKCB IGFBP4 PRKCE IGFBP2 PRKCA DGKZ MYL4 CACNB3 ADCY9 PRKAR1B PRKAR1A MYL2 PRKCQ PRKD1 ATF5 ATF3 ATF4 CALCA LPAR1 HEL-S-14 ITPR2 PRKCZ CRHR1 CNN2 GRK5 GRK4 CALD1 PLCG2 SFN PLCG1 IGFBP6 JUN GNG12 GNG11 NFKB1 GNG13 PKIB IL6 SP1 PKIA GNB2 MAFF GNB1 GNAS GNB4 GNB3 RLN1 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADM OXT ARRB2 RYR3 GNGT1 YWHAQ PS1TP5BP1 PDE4B HEL-S-1 YWHAG GABPA HEL-S-21 PDE4D FOS YWHAZ CREB3 ACTA1 PLCB3 CREB1 IL1B CRH RGS18 RGS17 CAMK2D RAMP2 RAMP3 RGS14 ATF6B 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome MYC DYNC2I2 HEL-S-71 NRROS TFRC CEP19 HFE SLC40A1 PIGX H2BC21 UBXN7 SMCO1 DYNC2H1 NCBP1 DYNLT1 NCBP2 DYNLT3 ADAM10 SLC51A SLC51B SIRT1 DYNLL2 FNDC8 RNF168 PIGM MFI2 DYNLT2B PXN MYCBP2 RNF8 PIK3R3 FBXO45 HIF1A DYNC2LI1 ZDHHC19 BRINP1 STAT5B TM4SF19 CEP350 MCRS1 RABL2B MAD2L1BP WDR53 ZNF76 TF DYNLRB2 NF2 DNCL1 HAMP TGFB1 JUN FBXW7 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260211%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260211%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 E2F3 MYC PIK3R1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260211%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NFKB1 PARP1 NAMPT TFAM HIF1A PPARG FOXO3A ROS1 SIRT1 SIRT3 FOXO1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 MAPK1 MAPK3 PIK3R1 SLBP CBL FGF2 ERI1 NSD2 TMEM129 CLTCL1 NELFB UBE2J2 FAM53A NELFCD NELFA POLN H3F3B FRS2 CKAP5 LETM1 NICOL1 TACC3 GRB2 NAT8L SOS1 FGFR3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260211%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2C MEF2B CCND2 NKX2-5 KLF4 MEF2D CAMK2D MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260211%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260211%WP5548%HOMO SAPIENS Blood based neuroinflammation markers ADM CRP PBR GRN CCL23 CCL11 BDNF TREM2 DBI S100B TREM1 CX3CL1 IL6 GFAP CCL5 IL1B OLR1 TNF CHI3L1 NEFL CCL2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260211%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 APOB LDLR PLTP USF1 GPIHBP1 LPL GHR LIPC EPHX2 APOA2 PCSK9 LUPUS THERAPIES%WIKIPATHWAYS_20260211%WP5560%HOMO SAPIENS Lupus therapies IL6 C1QB C1QA CD40 IL25 CD80 C4B_2 C2 C4A CD19 IL12B TNLG7A IL12A IL6R HEL-S-62p CD40LG IFNG IL23A IL17F IL17D IL17C MS4A1 IL17B CD22 IL17A C1QC EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260211%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1H1 DYNC2H1 DCTN1 TRAK1 ATAT1 DYNC1LI2 RHOT1 SYPL1 CASP3 MAP2 BAX MFN2 KIF1B RABAC1 DYNC1I1 RAB7A SNCA DYNC2I2 CASP8 RAB3B ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B ALSTROM SYNDROME%WIKIPATHWAYS_20260211%WP5202%HOMO SAPIENS Alstrom syndrome VCP IFT172 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 CEP192 E2F4 CIMAP3 SNAPIN PTCH1 CEP19 RFX2 DTNBP1 RFX3 RFX1 ACTN4 TUBG1 DNM3 TFDP2 SMO RILPL1 IFT81 MYO5B GPR161 ALMS1 IFT27 STX5A IFT25 RABL2B SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 SMAD4 HEL113 TNC RUNX2 CDH6 CDH2 ID1 SNAI1 SNAI2 CDH16 AKT3 MAPK1 MAPK3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260211%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ITPR2 TPH2 TPH1 KDM3A GRIN1 CHRM1 KDM1A KDM1B CYP27B1 CALB1 RXRA KDM6B NR1i1 ATP2B4 ATP2B3 ATP2B2 ATP2B1 HEL-75 CYP27A1 GCLC KCNQ2 BCL2 SLC8A1 KCNQ3 PVALB NFE2L2 CACNA1C GRIN2B VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260211%WP3871%HOMO SAPIENS Valproic acid pathway HADHB CYP2C9 CYP2A6 HSD17B10 CYP2B6 HDAC1 EHHADH IVD ABAT ACADSB FERROPTOSIS%WIKIPATHWAYS_20260211%WP4313%HOMO SAPIENS Ferroptosis TFRC SLC40A1 CYBB GCLC STEAP3 CISD1 SAT2 SLC7A11 BACH1 MAP1LC3A MAP1LC3C AIFM2 FTH1 SLC39A8 HEL-S-64p HEL-S-102 SLC38A1 GPX4 ACSL1 SLC11A2 ACSL6 FACL4 ACSL5 ACSL3 TF SLC39A14 POR DKFZp762B153 CHMP6 CHMP5 FTL IREB2 ALOX15 SLC3A2 HMGCR DPP4 FTMT CBS PCBP1 PHKG2 HMOX1 FDFT1 ATG5 PRNP AKR1C1 AKR1C2 CP COQ2 LPCAT3 VDAC3 CTH GCLM NOX4 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260211%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX1A SLC25A4 NAPA SNAP25 SLC22A3 STXBP1 CLTC DNM3 CACNA1B CLTA SLC1A3 CACNA1A AP2A1 CPLX2 CLN8 CPLX1 AP2A2 HEL-S-67p RIMS1 AP2S1 SLC17A6 SLC17A7 SLC17A8 CLTCL1 STX2 SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13B UNC13C UNC13A SYT1 SLC32A1 SLC38A1 SYP SYN2 SYN1 STX1B STX3A VAMP2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260211%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming IFITM3 ANKRD13C CREBBP HDAC2 CADM1 IRS1 TET2 EP300 PIP4K2A HDAC1 NOL9 EZH2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260211%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPG GATA3 GATA2 KLF15 KLF2 PPARG DDIT3 CEBPA CEBPB EGR2 KLF5 CEBPD ROTENONE METABOLISM%WIKIPATHWAYS_20260211%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260211%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins DKFZp762B153 RB1CC1 RAB7A ATG5 PRKAA2 CALCOCO2 HEL-S-30 PPP1R9A RPTOR LARP1 MTOR ULK1 DEPTOR LAMP2 MLST8 VPS11 APOB VPS39 EIF4B VPS16 ATG3 VPS18 GABARAPL2 VPS33A RPS6 ATG9A ATG12 VAMP8 TMEM59 RPS6KB1 RHEB ATG16L1 AKT1S1 VPS41 NBR1 LAMTOR1 SQSTM1 ATG2B OPTN INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 GRN SIRT1 RHEB MYCBP2 RB1 SMEK1 ZMYND8 NAB1 DHTKD1 MAP3K7CL AHR STK11 CCND1 ZMIZ1 CHEK2 ALKBH1 CHEK1 DAG1 RPP38 RALGAPA1 TSC2 CSNK1D TSC1 ARAF PPP4R3B BAX MYT1 RHO CCNB1IP1 CDC25B PIAS1 MSH6 EDAR MSH2 LGALS13 BLM MAX RASGRP3 RAP1A RRAS NUP85 TPR BARD1 CASP8 UBE2F SMAD1 PLK3 APOBEC3G GADD45A PIK3R2 XRCC3 PLK1 ERAL1 SMAD6 SMARCA4 FADD FOSL2 FOSL1 FER CDK7 NOXA1 NF1 MDM2 ATM ZNF655 MAP3K13 CERK BMPR1A ATR PIGR GSK3A BMPR2 GDI1 TRADD PTEN BRCA1 BRCA2 RASGEF1A RAC1 JAK1 ANXA1 DCAKD TGFBR2 ITPKC USP15 RALA USP16 SELENOK TFPI SMAD2 EGFR SMAD4 AURKA PAK1 BAK1 STAT1 USP21 MRE11A BRAF PML HIPK2 VEGFA TGFBR1 MAP3K7IP1 FOXO1 WEE1 RAD50 RAD51 FILIP1 CTNNB1 FAU CDK4 MYC IRS1 CDK2 MAPK1 KRAS ATF1 BCL2 HDAC1 BACH1 CASP9 CASP3 CHUK HMGCR JUN NFKB1 SP1 PKIA BAD MTOR CDC42 CREB1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260211%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS CASP9 CASP3 APAF1 BAX TNFRSF1A NEF3 TOMM40 SLC1A2 DERL1 HEL-S-2 TNF NEFH NEFL MAP2K6 MAP3K5 GPX1 BAD HEL-S-44 MAPK14 MAP2K2 CCS SMIM40 RAB5A BCL2L1 BCL2 PPP3CA CASP12 RAC1 PPP3CC VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260211%WP1533%HOMO SAPIENS Vitamin B12 metabolism RELA INSR CRP CBS INS NFKB1 IL6 CCL5 TNF CCL2 CTH HEL-S-44 SCARB1 APOB SERPINA3 LDLR MTRR SAA4 HBB APOE MTR PLAT PLG HEL-S-51e MPO MCEE ABCA1 FGA CUBN CBLIF HBA2 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG TCN2 TCN1 IL1B ALB SAA1 SAA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP3925%HOMO SAPIENS Amino acid metabolism TPH1 HEL-S-30 HEL-75 EHHADH PDHX FH HEL-S-133P SUCLG1 HEL-S-64p PNMT HEL-S-32 HEL-S-61p DBH FTCD GLS TDO2 HEL-S-53e PDK4 ACADM PIG59 HEL-S-4 ARG2 RARS1 ARG1 GPT2 MCCC1 CAD SDHA HEL-S-26 CBS ACLY LARS2 SMS BCAT1 ALDH7A1 DLD DDC ADH1C PPM1L MAOA HDC ADH7 CTH ADH5 GCLM SRM HMGCL TPO PCK1 ACSS1 PDHA1 MDH2 GOT2 ASNS ASS1 CS GLUD1 G6PC2 HAL PC TH EPRS1 P4HA2 OGDH ACO2 ALDH18A1 IARS OTC FARSB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 TDO2 IDO1 FOXO1 KLF5 CDKN1A IFNB1 IFNG AADAT HEL-S-90n HAAO TNF IL1R2 EIF2AK1 AHR EIF2AK4 KMO KYNU AFMID IDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260211%WP2037%HOMO SAPIENS Prolactin signaling ITGB1 HEL-S-130P PRL HEL-S-69p PAK1 RPS6KA2 SIRPA RELA STAT1 NEK3 CISH GAB2 PRLR VAV1 VAV2 ZAP70 PPIB SRC SHC1 AGAP2 SOCS2 MYC SOCS3 SOCS1 IRS1 ERBB2 EIF4EBP1 MAPK1 FLNA FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 NFKBIB RAF1 RPS6 RPS6KB1 PXN STAT5B GSK3B MAPK9 MAPK8 CASP3 STAT3 JUN PIK3CA NFKB1 MTOR PIK3R2 PIK3R1 CBL YWHAG FOS YWHAZ RAC1 JAK1 HRAS GRB2 SOS1 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260211%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap ETHE1 MAT1A SQOR SUOX CDO1 MTR HEL-S-64p CTH HEL-S-61p CBS GCLC COMPLEMENT SYSTEM%WIKIPATHWAYS_20260211%WP2806%HOMO SAPIENS Complement system CRP CSNK1A1 FCN1 FCN2 CLEC4M CD40 ITGB3 PLG PROS1 ITGA2B ICAM2 F13A1 C2 C4BPA C4A FGA LAMC1 CD19 C8A FCGR3A IBSP RPS19 C1QBP PRKCA HEL-S-62p HEL-S-78p C3AR1 VSIG4 MBL2 CR2 CR1 ALB CD93 ITGA2 HEL-S-92n PLAUR DCN FCER2 SERPING1 MASP2 MASP1 CD46 CFD LAMA5 FKBP2 SELPLG SFTPA2 CFH C5AR2 CFI C5AR1 WAS FPR1 GNAI3 TXN HEL-S-99n CFP THBS1 CPN1 VTN PRNP GNA15 C6 C7 C9 SPP1 CD59 CD55 ELANE F10 F11 LAMB1 SELE SELP SELL CFHR2 ADM CFHR4 PTX3 ARRB2 SFTPA1 KLKB1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260211%WP4917%HOMO SAPIENS Proximal tubule transport SLC34A3 ATP6V1G1 SLC6A19 ATP6V0B ABCC2 SLC6A18 SLC36A2 ATP6V0E1 SLC34A1 SLC16A10 SLC3A2 ATP1B1 SLC9A3 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ABCG2 ATP6V1B1 SLC47A2 ATP6V1A SLC22A6 ABCB1 SLC47A1 SLC22A2 SLC1A1 SLC2A2 SLC3A1 SLC5A1 ATP1A1 SLC5A2 SLC6A20 SLC4A4 AQP1 SLC5A5 CLTRN CA4 ATP6V0A4 ATP6V1E1 ATP6V1D ATP6V1C1 ATP6V1F SLC22A11 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260211%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway ACTA2 COL1A1 RAF1 SMAD4 TGFB1 CTGF TGFBR1 NOX4 HIF1A RRAS SP1 IL11 JUND MAPK1 IL11RA MGRA MAP2K6 ACE2 PTPN11 COL1A2 TGFBR2 PDGFD AGTR1 IL6ST OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260211%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH3 NOTCH1 DMP1 HNF1A BMP7 KLF4 DSPP ALPL RUNX2 SP7 SOST CTNNB1 DKK1 NOTCH2 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260211%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies GSK3B SMAD2 CREBBP TGFB1 RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 WNT7B CEBPD CTNNB1 CDK4 MAOA SPP1 APC CSNK1A1L NOTCH1 PPARG WNT10B HDAC1 LEF1 TNFRSF11B PS1TP5BP1 ZMPSTE24 FNTA CTSK LMNA HES1 EMD JUNB HES5 TCF7L2 CDKN1A TCF7L1 ICMT RB1 HMGA2 DICER1 LEMD3 TARBP2 GDF8 KAT2B BMP2 MYOD1 AGO2 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG MAFK COX1 NFE2L2 PTGS2 CYP2A6 VEGFA JUN FOS NFKB1 IKBKB NFKBIA KEAP1 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 SC5D DHCR24 DHCR7 LBR NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members GSK3B CREBBP EP300 CHUK ZC3HAV1 RELB TBK1 IKBKG BTRC SKP1 TIPARP TFPI2 PARP16 PARP14 PARP12 RBX1 PARP10 CLDN6 MAVS MAP3K14 RIGI NFKBIA ERN1 PARP1 NFKB2 IKBKB LUPUS PATHOGENESIS%WIKIPATHWAYS_20260211%WP5559%HOMO SAPIENS Lupus pathogenesis ICOS TLR4 ICOSLG CD40 CD80 TNLG7A IL6 CD40LG IFNA2 TNFRSF13C BCR TLR9 IL17A TLR7 PDCD1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3945%HOMO SAPIENS TYROBP causal network in microglia HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 TGFBR1 IL10RA SLC7A7 LHFPL2 HIMAP2 GAPT NRROS GPX1 RGS1 HEL-S-62p C1QC SPP1 CD84 ITGAM FKBP15 NCF2 PLEK LOXL3 TCIRG1 PPP1R18 CXCL16 PYCARD LYL1 RPS6KA1 CREB3L2 ITGAX CD37 GAL3ST4 IL13RA1 RNASE6 IL18 HEL-S-66 TNFRSF1B RUNX3 LGALS9C APBB1IP MAF TYROBP BIN2 ELF4 NPC2 DPYD EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260211%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance EGFR PDGFA NRAS BRAF IGF1 VEGFA IGF1R SRC KDR SHC1 PDGFRA PDPK1 MYC HGF AKT3 RRAS2 NRG1 ERBB2 NRG2 EIF4EBP1 MAPK1 SOS2 KRAS MET MAPK3 SHC4 SHC2 MAP2K1 SHC3 PDGFD MAP2K2 TGFA BCL2L11 ERBB3 PDGFC BCL2L1 EIF4E BCL2 EGF RAF1 AXL RPS6KB2 FGFR2 RPS6 RPS6KB1 PRKCB IL6R PRKCA PIK3R3 CCND1 GSK3B PIK3CD STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA IL6 RRAS BAD MTOR PIK3R2 PIK3R1 FOXO3A NF1 FGF2 PTEN JAK1 HRAS GRB2 SOS1 FGFR3 COCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGS2 PPARG PTGFR HEL-S-298 EHHADH HPGD PTGDR2 CYP4A22 AKR1B1 PLA2G5 PLA2G6 NR1C2 PTGS1 TBXA2R PTGDR PTGIR PTGIS PLA2G4B CYP4F2 CYP4A11 PTGR1 CYP4F12 ACOX1 PRXL2B ACOX3 PTGES INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260211%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IF2B1 TLR4 IL23R RORC RORA SMAD2 NOD2 IL2RG IL-21 TGFB1 HLA-DMA STAT1 STAT3 IL18RAP TBX21 STAT4 IL21R IL12RB1 IL10 JUN IFNGR1 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL2 IL4 IL6 IL5 TLR5 TNF IL12A IL18 IFNG IL23A IL17F MAF IL1A IL3 SIGNALING%WIKIPATHWAYS_20260211%WP286%HOMO SAPIENS IL3 signaling PIK3CD MAPK8 TGFB1 STAT3 GAB2 VAV1 JUN SRC SHC1 CXCL8 IL5RA MAPK1 CSF2RB CRKL FYN MAPK3 INPP5D BAD ENPP3 PTPN11 CCR3 MAP2K1 LYN PIK3R2 SYK PTPN6 PIK3R1 IL3 IL3RA BCL2L1 BCL2 RAPGEF1 CD69 RAF1 YWHAQ CBL HEL-S-1 FOS JAK1 STAT5B HRAS GRB2 SOS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NFKB1 SP1 MAOA GPX1 HEL-S-44 MAPK14 HEL-75 CYBB GCLC MGST1 GSTT2 NFE2L2 TXN2 UGT1A3 XDH NQO1 GPX3 TXNRD2 NOX3 CYP1A1 NOX5 JUNB FOS NOX4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260211%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260211%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 FABP6 SLC10A2 ABCB11 ABCC2 SLC51A SLC51B ABCB1 ABCC3 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260211%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI LATS1 TEAD4 LATS2 HDAC3 NF1 HDAC1 SIN3A MERTK SKIL TEAD2 TEAD3 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260211%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ECHS1 ACSF3 ACAT1 PCCA PCCB DBT MLYCD BCAT2 MCCC1 IVD ACADSB BCAT1 DLD HSD17B10 ACAD8 MCCC2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260211%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3927%HOMO SAPIENS BMP signaling in eyelid development NOTCH1 EGFR SMAD4 MAPK9 FGFR2 FOXC2 FOXC1 MAP3K1 INHBB BMP4 JUN SHH SFRP1 DKFZp781O1323 PITX2 FGF10 DKK2 MAPK3 SMAD1 TGFA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260211%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling IFITM3 MAPK10 MAPK9 MAPK8 RPS6KA2 MAP3K1 JUN IFITM1 IFITM2 RPS6KA3 MAP2K3 MAPK1 MAP2K4 MAPK12 DDIT3 MAP2K6 MAPK3 MAPK13 BST2 ATF2 MAPK11 MAP2K1 MAPK14 IFI27 MAP2K2 MAP3K10 MAP3K11 EIF4E BCL2 RAF1 RPS6KA1 JUNB FOS FOXA2 PATHWAY%WIKIPATHWAYS_20260211%WP5066%HOMO SAPIENS FOXA2 pathway GSTM2 MTTP APOB ACACA MLXIPL ABCC2 FASN PPARGC1B SLC27A5 FOXA2 FOXO1 ABCC3 INS SLCO1B1 IRS1 FOXA1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP229%HOMO SAPIENS Irinotecan pathway SLCO1B1 ABCC2 ABCG2 BCHE CYP3A4 CES2 UGT1A10 CES1 ABCC1 UGT1A1 UGT1A9 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260211%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 WNT3 LRP6 FZD3 WNT3A NEUROD1 CCND1 PROX1 NEUROG2 WNT7A NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260211%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 TICAM1 PARP1 TRADD FADD MAPK8 FTL CASP8 TNF RIPK3 TNFRSF1A CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260211%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia SMAD2 SMAD4 RELA EP300 CHUK STAT3 RELB IGF1 CEBPB IKBKG IGF1R TNFRSF1A NFKB1 IL6 TNF RPTOR MAPK11 MTOR NFKBIA MLST8 FOXO3A AKT1S1 TWEAK IL6R MAP1LC3A TRIM63 TNFRSF12A NFKB2 IL1R1 IKBKB FBXO32 ACVR2A IL1B REL JAK1 GDF8 IL1A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260211%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT ZMPSTE24 LMNA BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260211%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment BDNF SHC1 PDPK1 EIF4EBP1 PTPN11 NFKBIA BCL2L11 EIF4E RPS6KB2 RPS6KB1 MAPK8 STAT3 BAX CASP8 RAPGEF1 FADD TRADD IKBKB RAC1 SMPD1 HRAS PAK1 NRAS MAP3K1 CTNNB1 MYC IRS1 MAP2K4 MAPK1 KRAS MAPK3 MAP3K5 MAPK11 MAP2K1 HEL2 MAP2K2 BCL2 RAF1 BMP7 LEF1 PRKCH PRKCB PRKCE PRKCA TCF7L2 TCF7L1 ARHGAP35 CFL2 PRKCI TIAM1 PARD3 MAPKAPK2 CYCS RTN4R IQGAP3 GSK3B HEL-S-15 NPTX2 PIK3CD MAP2K5 PRKCZ NGFR CASP9 EEF2 TP73 DOCK7 CHUK WASL APAF1 EEF2K TRAF6 CRK PLCG1 IKBKG ROCK1 ROCK2 JUN HEL-S-47e PARD6B PIK3CA PARD6A MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 LIMK1 ARHA BAD MTOR CDC42 FOXO3A YWHAQ HEL-S-1 YWHAG YWHAZ CREB1 FRS2 GRB2 SOS1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FGFR2 PIK3R3 MAPK10 MAPK9 MAPK8 FZD10 PTCH1 SMAD1 PIK3R4 PIK3R2 PIK3R1 SMO FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 SMAD4 RUNX2 STAT1 FGFR4 BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 WNT5B NOTCH2 NOTCH3 NOTCH1 PRKCH PRKCB PRKCE PRKCA WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PRKD1 BMP2 MYOD1 WNT2B PIK3CD PRKCZ WNT16 PIK3CA MAPK7 LRP5 LRP6 IHH RBPJ FGF7 FGF8 FGF9 SOX9 HES6 PRKDC PIK3R5 JAG2 FZD4 SMAD9 FGF18 FGFR1 PPARG PIK3C2G PIK3C2A GLI3 PIK3C2B HEY2 FGF2 WNT9B FGF7B WNT9A FGF7A WNT8A WNT8B DLL3 DLL4 HES3 MAPK6 HES2 MAPK4 FGF5C FGFR3 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260211%WP5088%HOMO SAPIENS Prostaglandin signaling NLRP3 MMP9 IRF7 KLRD1 TGFB1 CCR2 VEGFA NFKB1 IL6 CSF1 CXCL8 TNF CCL2 PYCARD IL12A IFNG IL1B IL17F PTGER4 CXCL9 IFNA1 AHR PTGER2 CXCL1 IL17A AREG CCL3 IL1A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260211%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260211%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF CNP ASCL1 CXCL2 MBP MYT1 SOX8 SOX6 IGF1 SOX5 NKX2-2 BMP4 SHH NKX2-6 MOG LIF OMG OLIG1 OLIG2 SOX10 TNF SOX9 FGF2 IL1B BMP2 CXCL1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A FAN1 CREBBP CHRNA7 ARHGAP11B GOLGA8R CCL5 MTMR10 KLF13 OTUD7A FYN GPR75 GOLGA8O KAT2B GOLGA8Q TRPM1 FANCD2 GRM6 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKB1 MUC1 IL6 IKBKB CHUK RELA TNF NFKBIA IKBKG MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CCNG1 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260211%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER1 ADCY3 PTGER3 ALOX12 LTC4S PTGS2 GNAI1 ALOX5 ALOX15B ALOX15 ALOX5AP NRAS KRAS GNAS MAPK11 SIRT1 IGFBP5 PTGS1 CDKN1A RB1 PTGIS PTGER4 HRAS PTGER2 PRXL2B PTGES CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260211%WP3594%HOMO SAPIENS Circadian rhythm genes ADCY1 HDAC2 EP300 EZH2 PRKAA2 SIRT1 AHR RORC MAPK10 RORA MAPK9 MAPK8 CSNK1D C1orf51 CRTC1 NPY2R PRF1 UBE3A RORB CCAR2 PPP1CC HTR7 CSNK1E PROK2 HEL-S-80p AgRP PROK1 CHRNB2 UTS2R CPT1A FBXW11 KCNH7 USP2 METTL3 DYRK1A SOX14 CARTPT MTNR1A CLDN4 MTNR1B PSPC1 TIMELESS UTS2 SIK1 DDX5 MAGEL2 KMT2A MAGED1 BHLHB2 CREM TNFRSF11A NPAS2 RAI1 AANAT UBC NKX2-1 DRD1 PTEN DRD2 DRD3 PPARGC1A DRD4 HDAC3 EGR1 SIN3A ZFHX3 OPN4 OPN3 HOMER1 NONO GFPT1 NR1D2 NR1D1 BTBD9 NR2F6 SETX STAR ID2 ID4 HNRNPD ID3 FBXL3 PML SLC9A3 TCF2 OGT ADA TPH2 TOP2A TPH1 KDM5A SUV39H2 CHRM1 SUV39H1 FAS BHLHE41 CDK4 NR1C1 HEBP1 RBM4 DBP JUND SIX3 HEL-S-2 KLF10 KCND2 SFTPC PAX4 MC3R SFPQ NCOR1 ADORA2A THRAP3 MTTP CRY2 KCNMA1 CRY1 AVP NLGN1 PRKAA1 PHLPP1 CIPC HDAC1 CRX RBM4B TYMS NPS PROX1 ATOH7 PROKR1 NFIL3 GNA11 NOCT RPS27A NTRK1 ARNT2 F7 NTRK3 CAVIN3 NR1H3 PASD1 HCRTR2 HS3ST2 HCRTR1 PER2 ATF5 PER1 PER3 ATF4 MYBBP1A GSK3B GHRH LEP KLF9 GHRL NGFR BMAL2 RELB BTRC ROCK2 SKP1 JUN IL6 DDC NOS2 PRKDC NAMPT PPARG TH CREB1 CRH GPCRS OTHER%WIKIPATHWAYS_20260211%WP117%HOMO SAPIENS GPCRs other GPR17 P2RY11 HTR1F OR2F1 GPR55 EMR3 ADGRD1 GPR143 GPR183 CCR2 OR2A5 LGR6 OR2A4 ADGRL2 GPR18 ADGRL3 OR7E24 ADORA2A GPR83 PTGFR CHRM2 CHRM3 OR1G1 OR2M4 GPR61 C5AR2 ADRA1D HTR2A GPR62 CELSR1 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 HTR7 EDNRA GPR176 GPR132 GNRHR CCR5 GPR135 UTS2R ADGRV1 ALG6 OR1F1 F2R OR2H1 TAAR5 OR1J2 TAAR2 SSTR2 OR1N1 SMO GPR162 CCKBR OR5AC2 FSHR ADGRF5 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 ADRB2 IL8RB MCHR2 GHRHR DRD3 FY CXCR1 DRD4 CNR1 CXCR3 S1PR1 OR2B6 NTSR1 OR5D3 P2RY13 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5049%HOMO SAPIENS Glycolysis in senescence ENO1 HEL-S-68p RB1 PRKAA1 HEL-S-133P HEL-S-30 HEL-S-162eP RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP5188%HOMO SAPIENS Retinol metabolism HEL-S-53e CYP2A6 CYP1A1 ADH1A RPE65 DHRS4 CYP3A7 SDR16C5 CYP2W1 RDH12 DHRS9 AWAT2 PNPLA4 AOX1 LRAT BCO1 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260211%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PLCB1 CRTC2 INSR PRKAA2 EIF4EBP1 RPTOR PRKAG1 PRKAG2 SLC2A4 ADRA1B ACACA ELAVL1 ADRA1A FASN RPS6KB2 PRKAG3 PPARGC1B NR2A1 PRKAA1 GYS2 GYS1 LIPE PRKACG LEPR PRKAB2 STRADA RPS6KB1 STRADB CPT1C PRKAB1 CCNA2 CAB39 PIK3R3 ADIPOR1 ACACB ADIPOR2 CAMKK1 CCNB1 CAMKK2 INS-IGF2 SLC2A4RG STK11 LEP PIK3CD TSC2 EEF2 TSC1 EEF2K HMGCR PIK3CA CPT1A MTOR PIK3R2 PIK3R1 CDKN1A IL2 SIGNALING%WIKIPATHWAYS_20260211%WP49%HOMO SAPIENS IL2 signaling IL2RG STAT1 STAT3 CISH GAB2 SHC1 IL2 SOCS3 MAPK1 CRKL FYN MAPK3 PTPN11 MAP2K1 MAP2K2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 CBL RPS6KB1 JAK1 STAT5B PTK2B HRAS JAK3 NMI GRB2 LCK IL2RA SOS1 IL2RB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL15 F2RL1 IL2 ITGB7 EGFR DHODH IFNG IL-21 TNF NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260211%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX EIF2S2 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF2S1 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP5094%HOMO SAPIENS Orexin receptor pathway STAR RUNX2 CXCL2 FOXO1 DKFZp781O1323 PDPK1 SLC1A2 EIF4EBP1 MAPK1 TNF MAPK3 PTPN11 MAP2K1 MAPK14 MAP2K2 SLC2A4 EIF4B DYNLT1 BMP7 NFE2L2 DYNLT3 PRKAA1 RPS6 RPS6KB1 PRKCB GNA11 PRKCE PRKCA HIF1A CAMKK2 HCRTR2 HCRTR1 PRKD1 LEP GHRL CASP9 PRKCZ MAPK9 MAPK8 CASP3 GNAI1 STAT3 IL10 MAPK7 IL4 NPFFR1 IL6 DAGLA CXCL8 FSHB SGK1 LHB BGLAP NPY SMAD1 GNAS NPVF VHL MTOR CGA PIK3R2 HCRT PIK3R1 OPRK1 GCG CCK POMC GH1 IL9 GNRH1 ARRB2 TH RPS6KA1 BMPR1A NOX4 CREB1 IL1B MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260211%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB SDHA CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260211%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP16 MMP9 PRKD3 MMP15 MMP23B PRKCZ SCN8A MMP17 MMP19 BDNF NOS2 SNAP25 AGER SLC2A3 PRKCH MMP21 MMP20 PRKCB MMP25 MMP24 PRKCE MMP27 SCN9A HEL-S-62p PRKCA MMP28 MMP7 TRPA1 MMP2 MMP3 SORD TRPV1 PRKCI MMP10 PRKCQ MMP12 MMP11 SCN10A MMP14 CYTOSINE METHYLATION%WIKIPATHWAYS_20260211%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260211%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260211%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR TXN AMD1 APIP MAT1A SMS MRI1 IL4I1 MSRA MTAP ADI1 CHDH MSRB2 MSRB3 ENOPH1 SRM HEL-S-61p HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260211%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHA TFAP2A ARHGAP29 ARHGEF2 IRF6 TP63 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260211%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KDR PDGFRA PDPK1 HGF PRKAA2 MET RPTOR MLST8 PDGFC SLC2A4 EIF4E EIF4B EGF ELAVL1 RPS6KB2 FGFR2 GYS2 GYS1 RPS6 LIPE STRADA RPS6KB1 RHEB AKT1S1 CAB39 HIF1A JAK3 STK11 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 ULK1 PIK3R4 PIK3R2 PIK3R1 IL3RA MDM2 SLC2A3 PTEN IKBKB JAK1 HRAS EGFR FGFR4 NRAS VEGFA FGF10 CSF1 IRS1 IRS4 MAP2K1 MAP2K2 FOXA1 HEL-S-125m TCL1B TCL1A ACACA PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 PELO CDC37 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 HIF3A GNGT2 FGF8A RAB8A OSMR COL2A1 KIT PHLPP2 COL11A2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD RAB11B NGFR COL3A1 CASP9 KITLG GHB3 CSF3 CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 PFKFB2 PFKFB1 CSF1R PFKFB4 EFNA5 EFNA4 CHAD FGF20 NOS2 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 FGF16 EFNA3 FGF14 EFNA2 PIK3R5 COL5A3 COL5A2 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 ITGB4 PIK3C2A FLT4 LAMC2 PIK3C2B ITGAE FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C ANGPT4 ANGPT2 ITGB1 LAMB3 ANGPT1 PRL LAMB2 PPP2R3A EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PRLR PPP2R2B PPP2R2D EIF4EBP1 GHR CDKN1B ITGB3 ITGA2B LAMC1 IBSP IL6R ITGA2 COMP COL1A1 LAMA5 THBS1 VTN SPP1 LAMB1 SLC2A2 PPARGC1A CRTC2 TNC FLT1 INSR PDGFA IGF1 FOXO1 IGF1R INS CHRM1 AKT3 MAPK1 KRAS MAPK3 ATF2 COL1A2 PDGFD PRKAA1 PHLPP1 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 F2R GNB3 ITGAM GNGT1 CREB3L2 ITGAX CREB3 CREB1 ATF6B INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260211%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 AKT3 SNCA APP STAT1 CEBPB SRPK2 BACE1 SET BDNF TARDBP MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260211%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 BRAF JUN ALK KSR1 SHC1 FOS GAREM2 MYC KRAS SOS2 MAPK3 MAP2K1 MAP2K2 SOS1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260211%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR CREBBP HDAC2 RELA EP300 NFATC1 NFKB1 HDAC5 SUPT4H1 HDAC8 SP1 HDAC9 HDAC7 HEXIM1 NFATC3 NFATC2 SUPT5H NFATC4 NFKBIA CDK9 PPP3R1 PPP3R2 HDAC1 NELFB NELFCD NELFA PPP3CA HDAC3 PPP3CC TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260211%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NADSYN1 TDO2 NMNAT1 IDO1 NMRK2 NMRK1 NAPRT NAMPT AADAT HEL-S-90n HAAO KMO KYNU NMNAT3 AFMID NMNAT2 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP481%HOMO SAPIENS Insulin signaling RPS6KA2 SHC1 PDPK1 SOCS3 SOCS1 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 PTPN11 SHC3 SLC2A4 EIF4E RPS6KB2 INPPL1 CBLC RPS6KA4 GYS2 RPS6KA6 GYS1 LIPE RPS6KA5 GRB14 GRB10 ENPP1 MAP3K8 RPS6KB1 MAP3K6 RHEB GYG1 MAP3K7 INPP4A TRIB3 STXBP3 PIK3R3 STXBP4 RRAD PPP1R3A KIF3A STX4A RAB4A EHD1 EHD2 MAP3K12 ARF1 HEL-S-31 SNAP23 PTPRF FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 TBC1D4 SGK2 ARF6 SNX26 MAP4K3 MAP3K2 HEL-S-42 PFKL MYO1C PFKM SGK1 PIK3R4 PIK3R2 PIK3R1 RAPGEF1 XBP1 MAP3K13 GSK3A PTEN IKBKB RAC1 EGR1 HRAS INSR MAP3K1 FOXO1 IGF1R RPS6KA3 IRS1 MAP2K3 IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 HEL-S-61 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 PRKAA1 PRKCH PRKCB PRKCA PRKCI PRKCQ GSK3B PIK3CD MAP2K5 PRKCZ CRK JUN PIK3CA MAPK7 SH2B2 MAP3K14 MTOR SNAP25 STXBP1 FOXO3A PIK3C2G PIK3C2A CBL RPS6KA1 FOS MAPK6 MAPK4 GRB2 SOS1 VAMP2 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260211%WP3676%HOMO SAPIENS BDNF TrkB signaling ADCY1 TSC2 TSC1 EEF2K NRAS BRAF GAB2 PLCG1 BDNF GRIN1 SHC1 TRPC6 TRPC3 ARC NTRK2 DLG4 EIF4EBP1 MAPK1 KRAS MAP2K1 MTOR RPS6KA1 RPS6KB1 RHEB CREB1 HRAS GRB2 HOMER1 SOS1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades TFPI APOA2 C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2881%HOMO SAPIENS Estrogen receptor pathway PDK4 NR1C1 SP1 GPAM STAT3 CYP1A2 CYP1B1 NR0B2 ACOX1 CYP1A1 JUN PCK1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260211%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV STX1A CAMK2A CAMK2G GRIN1 ARC MAPK1 MAPK3 RYR2 NLGN1 NLGN3 CYFIP1 NLGN2 YWHAG NRXN1 FMR1 NRXN3 NRXN2 GRIN2B RPH3A SYNGAP1 DLGAP1 TJP1 DLG2 SHANK1 CAMK2D HOMER1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260211%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 NFKB1 IL18 IL6 MAVS IL1B CSF2 TNF CGAS RIGI CXCL9 MITA CCL2 IFIH1 CXCL11 IRF3 TLR8 TLR7 TLR3 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260211%WP1604%HOMO SAPIENS Codeine and morphine metabolism CYP2C8 UGT2B4 UGT1A8 UGT2B7 ABCC2 UGT1A3 UGT1A10 UGT1A1 ABCB1 UGT1A9 ABCC3 SLCO1B1 CYP3A4 IL17 SIGNALING%WIKIPATHWAYS_20260211%WP2112%HOMO SAPIENS IL17 signaling GSK3B TRAF3IP2 IL17RC IL17RB RELA STAT3 IL17RA TRAF3 TRAF6 CEBPB IKBKG CEBPD PIK3CA NFKB1 SP1 MAPK1 MAP3K14 MAPK3 NFKBIB IL25 MAP3K7 IKBKB IL17F IL17D JAK1 IL17C IL17B IL17A ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 UGT1A3 NQO1 CYP1A2 GSTM1 CYP1B1 UGT1A1 SULT1A1 STS UGT1A9 SULT1E1 CYP1A1 ARSL CYP3A4 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260211%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes MTX1 SPRYD4 CDKN2A AP3D1 TRMT1 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 TRIP13 LAMTOR3 LAMTOR5 LY6K PLXND1 TUSC2 GEMIN2 LTN1 CPOX ARID4B CALCOCO2 MSI2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 VPS39 KPNA3 EIF4E FADS1 AXL MYLIP ATG3 TNLG5A TPM3 TPM1 STX7 GYS1 UBE4A ATG9A CDKAL1 RAB30 GPD2 TMEM59 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 RAB5C CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP NPRC GAS2L1 SAC3D1 MCL1 CCND1 MPDU1 CD164 VCAM1 BRPF3 HMGA1 SLC4A10 TNFRSF10A NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 BCL6 TRPV6 UBE2S CHMP2A SRPRB MENT DKFZp761E1322 PICALM SLC25A1 DOCK5 ADPGK TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 PTBP1 SMAD1 DNMT3B TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 PPP3R1 UTP15 HSDL1 RBM19 SIGMAR1 ARID1A TXN2 NT5C3A RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 UNC93B1 NXN UHRF1 PLAG1 HSD17B12 MRM1 AURKB GNA13 DNAJB1 CAND1 PPP3CA POLR2C RAB23 TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT ABCF2 SLC25A22 PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 IRS1 MAPK12 MAPK14 TCL1A PPIF MTRR LPL RTN4 KIT PRKCI IQGAP3 DOCK7 RARS1 COL4A2 HEL-S-26 HEL-S-47e MAPK7 CDK6 E2F3 LAMC2 FGF2 P4HA2 NELFCD CDKN1A PPP2R5C PPIB BDNF CDKN1B MAP3K8 LAMC1 SMC1A C1QBP SUCLG2 TNFRSF10B ITGA2 SNAP23 PTPRF CAP1 ATAT1 SYPL1 TUBA1A FBXW11 GPAM DDX5 CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 ATP6V1F GFPT1 ATP6V0E1 CPNE8 VEZT SERPINE2 TMEM41B EHMT1 CLDN1 PWP1 ABCG2 DCAF7 RRP8 PNP DHX57 KRAS LOC541469 CHORDC1 RAVER2 MYB CIAO2A SEC62 GOLGA7 NOTCH2 CDK5RAP3 HOXA5 NOTCH1 BCL2 ARL10 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 OTULINL POM121 HACD3 MRPL20 BACH1 FXR2 COMMD9 TERT RDH10 GRPEL2 CEP72 KCNN4 VTI1B SNX6 SLC38A1 GSTM4 PHC2 HARS1 RAB27B BRI3BP PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B FERMT2 HOXD8 RNP24 RCOR1 CDKN1C NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MEOX2 MRC2 PANX1 COIL CHAF1A SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC ANXA2 MRPS24 ELOVL5 ATP2A2 ELMOD2 AP2A1 TMT1A AP3B1 PRPF40A RHOB SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN PTRH1 VAMP3 PRIM1 MRPS33 SSNA1 AMIGO2 AKAP8 NAPG HEL-S-66 PTPA PURA NT5E PGRMC1 PPP1R7 USP1 SHOC2 TAF9B SRSF10 MPZL1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP5485%HOMO SAPIENS Post COVID neuroinflammation TLR4 IL10 CCL11 TMPRSS2 IL12A FURIN IL2 HMGB1 IL4 IL18 IL6 GFAP IFNG CXCL8 IL1B MAPK1 TNF IFNA2 ACE2 TLR8 TLR7 IL1A TLR3 IL7 SIGNALING%WIKIPATHWAYS_20260211%WP205%HOMO SAPIENS IL7 signaling GSK3B IL7R IL2RG STAT1 STAT3 IL7 MAPK1 STAT5B FYN MAPK3 JAK1 BAD PTK2B JAK3 MAP2K1 MAP2K2 PIK3R2 PIK3R1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260211%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 CPN1 BDKRB2 KLKB1 BDKRB1 SERPING1 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260211%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260211%WP5574%HOMO SAPIENS Oligodendrocyte development ID2 ASCL1 ID4 MBP MYT1 SOX8 SOX6 NFIA SOX5 NKX2-2 EGR2 BMP4 SHH NKX2-6 PDGFRA OLIG1 OLIG2 SOX10 MYRF CHD8 PTN ZNF24 SMAD1 NFATC2 DUSP15 SOX2 NKX6-1 SOX9 ZNF488 LGI1 OPALIN SOX11 ZBTB33 ZEB2 BMP1 TMEM98 CNTN1 CSPG4 WNT10A FGF2 HES5 TCF7L2 PRKCA RELN SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260211%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN SIRT1 MTOR FOXO1 IGF1R NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260211%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC18A2 DDC MAOA SLC6A3 PNMT TH TPH2 DBH TPH1 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260211%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 ALPL HEL-S-302 PLPBP ALPI HEL-S-1a PIGV DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260211%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CSNK1A1 FOXO1 CDK4 DCAF7 RPTOR DEPTOR MLST8 CRY2 NOTCH1 CDKN1B SIRT1 PSEN1 LIN54 NEUROG2 GMNN HES1 DNER AKT1S1 LIN52 RBL2 HES5 RBL1 TFDP1 TFDP3 AMPH LIN37 LIN9 RBBP4 E2F5 EIF2B5 REST CCND1 TFAP4 SPRY2 GSK3B CASP9 TSC2 APP CASP3 TSC1 NFATC1 E2F4 MTOR DYRK1A TFDP2 CDK6 FGF2 CREB1 H3F3B LATS2 PSENEN BACE1 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260211%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRAK1 IRAK2 IRAK4 MAPK10 IRF7 SAFB MAPK9 TAB3 MAPK8 MYD88 RELA CHUK MBP TRAF6 MAP3K1 MAP3K7IP1 NFKB1 MYC MAP2K3 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB EIF4E RPS6KA5 MAP3K8 MAP3K7 FOS IL1R1 IKBKB MAPKAPK2 TANK IL1A GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260211%WP2363%HOMO SAPIENS Gastric cancer network 2 EGFR OTUD5 DGIC AHCTF1 LBR DSCC1 CHTF18 MTDH CHTF8 BRIX1 TOP2A RFC3 RFC4 UBE2C ATAD2 CACYBP CTNNB1 FAM91A1 MYC RNF144B LMNB2 UBE2T SNURF S100A6 CD48 CEBPZ COL9A1 COL9A3 RAD17 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260211%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 ITGB1 SMAD2 HEL113 FLT1 RELA CXCL2 CDH2 VEGFA SNAI2 IGF1R DKFZp781O1323 SRC KDR SHC1 PDGFRA CTNNB1 CLDN1 PDPK1 SOCS3 RPS6KA3 SOCS1 PRKAA2 MAPK1 TNF MAPK3 CCL2 MAP2K1 MAPK14 MAP2K2 ACACA ZEB2 RAF1 RPS6KA4 SP7 RPS6 RPS6KA5 RPS6KB1 PRKCB IBSP HEL-S-133P HEL-S-102 GSK3B ACTA2 MAPK9 MAPK8 TGFB1 CSF3 PLCG1 IL10 COL4A1 JUN NFKB1 IL6 CXCL8 CRKL CPT1A BGLAP SIX1 SMAD1 CXCL5 HK2 MTOR DUSP4 CLDN5 SLPI PIK3R1 PCNA MST1R SMAD6 KLK15 PARP1 SMAD9 FZD1 FGFR1 WNT10B NR0B2 RPS6KA1 FOS PTEN IFNB1 TJP1 IL1B PPARGC1A CSF2 EGR1 GRB2 CXCL1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders HIST1H2BE TERF2IP TPP1 H2BC21 H2AC19 H2AX H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 ACD H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 TINF2 H2BC1 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H2AJ H2BC14 H3-4 H2BC15 H2AC20 H2BC11 POT1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260211%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMP FPGS UPP2 TDG TK1 RRM1 RRM2 ABCC5 GGH SMUG1 DHFR UCK2 UCK1 ERCC2 UMPS SLC29A1 SLC22A7 ABCG2 XRCC3 CYP2A6 CES2 CES1 TYMS ABCC3 DPYD SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260211%WP4814%HOMO SAPIENS Somatic sex determination SOX8 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 WT1 WNT4 SRY RSPO1 AMH FGF9 SOX9 PDGF PATHWAY%WIKIPATHWAYS_20260211%WP2526%HOMO SAPIENS PDGF pathway MAPK8 PAK1 CHUK STAT1 STAT3 WASL PDGFA MAP3K1 PLCG1 VAV1 VAV2 JUN SRC SHC1 NFKB1 MAPK1 MAP2K4 ARHA MAPK3 PTPN11 MAP2K1 NFKBIA COX2 PIK3R1 CDC42 RAF1 FOS RAC1 JAK1 HRAS TIAM1 GRB2 SOS1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260211%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease NOTCH3 HEL25 MEF2C HP1BP3 HSPB3 HSPB2-C11orf52 tmp_locus_29 LBR H2AZ1 LMNA ACTA1 MYOD1 MYOG DMPK AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260211%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension UROC1 GLUD1 HAL GPT2 FTCD MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids PIK3CA CERS1 NFKB1 HIF1A ASAH2 TSC1 S1PR3 S1PR1 MTOR CERK SPHK2 IGF1R TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 MEF2C MEF2B CDKN2A CCND2 STAT3 BCL6 ID3 EZH2 IL21R NFKB1 MYC IL6 TLR5 TNFRSF13C BCR LYN TLR9 SYK TLR7 BCL2L1 ICOSLG CDKN1B CD40 SPI1 CD79B SPIB CCND3 CD79A POU2F2 TLR1 IRF4 POU2AF1 IRF8 TCF4 TLR10 TCF3 CDKN1A TLR8 TLR3 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3CD MAPK8 PAK1 STAT3 STRN ARAF NRAS BRAF CRK PLCG1 JUN ALK SRC PIK3CA RAP1A HGF AKT3 MAPK1 KRAS SOS2 CRKL MAPK3 MET BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 PIK3R1 CDC42 RAPGEF1 RAF1 CBL PIK3R3 CDKN1A PRCC RPL11 ELOA PAK6 RAC1 INSL3 PAK4 HRAS C8orf34 JAK3 GRB2 SOS1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 AIFM1 MIF ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260211%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R11 PPP1R10 PPP1R2 PPP1R8 PPP1R16B MAPK8 MBTPS1 PPP1R14A PPP1R14B PPP1R14C PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B HEL-S-89n PPP1R3E PPP1R1C PPP1CC PPP1R1B PPP1R3D PPP1R12B HEL-S-80p PPP1R14D PPP1R12C MBTPS2 DDIT3 PPP1R9A ERN1 BCL2 XBP1 EIF2AK2 MAP1LC3A PPP1R3A PPP1R7 EIF2AK1 EIF2S1 PPP1R15A PPP1R15B PPP1R13B ATF4 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260211%WP3601%HOMO SAPIENS Lipid particles composition APOB LDLR APOE APOC2 LPL APOC3 APOA2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2874%HOMO SAPIENS Liver X receptor pathway FASN RXRA CYP3A4 NR1H3 CYP2B6 ABCG8 ABCG5 SCD CYP7A1 IL9 SIGNALING%WIKIPATHWAYS_20260211%WP22%HOMO SAPIENS IL9 signaling IL9 IL2RG STAT1 STAT3 MAPK1 STAT5B MAPK3 JAK1 JAK3 MAP2K1 GRB2 MAP2K2 CDK9 IL9R PIK3R2 PIK3R1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2877%HOMO SAPIENS Vitamin D receptor pathway CDKN2A KLF4 CEBPA TREM1 CYP3A4 NFATC2 SLC2A4 ADRA1B CDKN1B TPM1 CD40 CDKAL1 IL25 IRF4 IRF8 IL12A NR1C2 HIF1A CCND1 TRAK1 TGFB1 ALOX5 BCL6 TRPV6 THBD BDKRB1 BGLAP SPP1 CYP7A1 GADD45A STEAP4 LPGAT1 CCNC GXYLT2 PRDM1 KNG1 CLDN2 SALL4 TNFSF11 LGALS9 EPHB4 SULT2A1 KRT71 SLC34A2 CCNE1 S100A2 ABCB1 MED9 CYP1A1 LCE1F LCE1D LCE2B CDC34 NINJ1 S100A4 S100A9 S100A8 TNLG2B COL13A1 CLEC16A KLK6 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 CD14 FGF23 HLA-DQA2 HLA-DQA1 KL SLC37A2 KRTAP12-2 KRTAP8-1 BMP6 CYP2S1 ID4 TRPV5 PNOC ID1 CLPTM1L STS MXD1 ALPG ZNF257 FOXO1 SPRR1B SFRP1 CD200 HLA-DRB1 ORM1 HILPDA TNFAIP3 MYC CYP27B1 ORM2 ADAMTS5 CDK2 SULT1C2 RXRA CASP14 DUSP10 NR1i1 ADGRE5 CASP5 DACT2 TIMP3 ATP2B1 CTLA4 SOSTDC1 KRTAP5-1 CA9 ABCD1 SLC8A1 CAMP HNF1A KRTAP5-4 KRT34 CEACAM1 CYP2C9 KRT38 DEFB4B CYP2B6 COLEC11 SATB1 TNFRSF11B PTH ALPI HEL57 IGFBP1 SEMA3B ASAP2 IGFBP5 CST6 PTHLH DNER IL1RL1 JUNB CST1 CLMN CREG2 HSD17B2 CDKN2D LRRC25 S100G KRTAP10-2 CDKN2B KRTAP10-4 PRKCQ CDKN2C CDX2 KRTAP10-7 MX2 KRTAP10-9 KRT13 G0S2 MYO9B DEFB132 CYP24A1 KRT16 CD9 CBS LRP5 EFNA5 S100A6 ITGAM ADRB2 CDKN1A PTGER4 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins PLCB4 TERF2IP PRKCZ MAPK9 CADM1 CSN3 GRIK2 GPHN CDH2 RAP1GAP CHL1 EPB41L3 NCDN CAMK2G MAP4 NEO1 CLASP1 GRIN1 NTNG1 GABBR2 KCNJ6 CADM3 CAV2 EFNA5 GABRG2 SNW1 DAB1 AGRN ATP2B1 KCNQ2 KCNMA1 CASK STX2 GRIN2B MAPK4 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT PPARGC1A SIRT1 IGF1 PRKAB2 MTOR EGF EGFR SIGNALING%WIKIPATHWAYS_20260211%WP437%HOMO SAPIENS EGF EGFR signaling MEF2C CAMK2A RPS6KA2 MEF2D GAB2 VAV1 NEDD4 VAV2 SRC SHC1 PDPK1 ERBB2 EIF4EBP1 SOS2 PTPN11 COX2 EGF INPPL1 CBLC RPS6KA5 GRB10 RPS6KB1 STAT5B PTK2B MAP4K1 MAPK9 MAPK8 STAT3 ARF6 MAP3K2 RAP1A CRKL INPP5D PIK3R2 PIK3R1 PTEN RAC1 JAK1 HRAS RALA EGFR PAK1 STAT1 BRAF MAP3K1 FOXO1 RPS6KA3 JUND MAPK1 KRAS ATF1 MAP2K1 MAPK14 MAP2K2 RAB5A RAF1 GJA1 PRKCB PRKCA PRKCI SPRY2 HEL-S-15 MAP2K5 PRKCZ CRK PLCG1 ROCK1 JUN MAPK7 CAV2 SP1 USP6NL SH3GL3 ERRFI1 MTOR NDUFA13 PLCE1 SH3GL2 STXBP1 RALBP1 PCNA CDC42 HGS STAMBP RIN1 STAM2 SH2D2A AP2A1 IQGAP1 FOXO4 PLD2 ATXN2 TNK2 PIK3C2B PTK6 CBL SYNJ1 AP2S1 RPS6KA1 HEL-S-34 PXDN NCK2 NCK1 VAV3 EPS15L1 FOS EPN1 AP2M1 PLSCR1 ARHGEF1 RALB CREB1 ASAP1 NEDD8 MAPK4 REPS2 RICTOR CSK LIMK2 GRB2 ITCH FOSB SOS1 PTPN5 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260211%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260211%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 CALM1 PDE3B RYR2 ADCY3 ADRA1B MYLK ADCY1 ADORA2B ADCY8 ADRA1A PDE4A ADCY6 PDE3A RYR3 ADRA1D PDE4B PDE4D HEL-S-80p PPP1R12C ADCY9 ADORA2A NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2064%HOMO SAPIENS Neural crest differentiation ITGB1 HDAC2 HDAC10 HDAC11 DMBX1 ASCL1 CDH6 MPZ CDH2 ZIC1 MBP HOXA1 ID1 FOXD3 SNAI1 SOX5 MSX2 SNAI2 MIA BMP4 OLIG3 PAX3 ISL1 DCT OLIG1 PAX7 CTNNB1 OLIG2 HAND1 HDAC5 MYC SOX10 HOXB1 CTBP2 HDAC8 GFAP DLX5 HDAC9 TWIST1 HDAC7 HDAC6 PRTG GBX2 MSX1 TFAP2A MYB TFAP2B ZIC5 TBX6 NOTCH2 PHOX2B NOTCH3 GJB1 NOTCH1 TLX2 LHX1 PMP22 BMP7 LHX5 NEUROG1 FGFR2 HDAC1 HES1 TCF4 DVL1 HES5 FGF8A DVL2 DVL3 TCF7L1 NFKB2 COL2A1 WNT1 COL11A2 WNT3A GSK3B AXIN1 AXIN2 NFKB1 RBPJ SMAD1 FGF8 SOX9 FGFR1 RHOB FZD3 HEY2 FGF2 WNT8A DLL3 DLL4 HDAC3 FGFR3 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN1 GRIN2B DLG4 NLGN1 GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 NLGN3 NLGN2 NRXN1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260211%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCB4 PLCH1 PLCH2 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 PIP4K2A PLCG2 PLCG1 PIK3CA MTMR10 INPP5D PIK3R4 PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260211%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 IL2 SPN CD27 CD3G CD3E CD3D CD80 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260211%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK1 RAD9A CDKN2A CASP9 CASP3 BAK1 TP73 APAF1 BAX YAP1 MRE11A MDC1 TRAF6 RIF1 SMC3 KAT5 TRIM28 HSF1 RAD50 TP53BP1 RAD51 BLM ACTL6A RASSF1 NABP2 MCPH1 ATF2 FANCD2 PCNA PRKDC PARP1 H2AX MDM2 ATM NBN ATR SMC1A RNF8 BRCA1 TERF2 LATS1 BRCA2 RAD52 CDK5 CHEK2 RAD17 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260211%WP430%HOMO SAPIENS Statin inhibition of cholesterol production HMGCR FDFT1 PDIA2 DGAT1 APOA5 SQLE APOC2 APOC3 SOAT1 ABCG8 APOC1 ABCG5 CYP7A1 LIPC APOA2 ACSS1 APOA4 SCARB1 MTTP APOB LDLR PLTP APOE LPL ABCA1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260211%WP2882%HOMO SAPIENS Nuclear receptors meta pathway EP300 ACKR3 HGF CYP2C19 CYP3A7 NRG1 CYP3A4 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 AHR CYP4F12 ACOX1 CCND1 IL2 APOA5 GCC1 TNS4 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 MGST1 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 ABCB4 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 CYP1A1 SLC19A2 SLC2A3 GSTM3 PLK2 ABCC3 SMARCA1 SLCO1B1 HEL-S-128m SLC6A5 SLC6A7 ABCB11 SLC6A8 SLC6A9 DNAJB1 CPEB4 GSTM5 SLC6A1 SLC6A2 EPB41L4B ENC1 ANKRD1 TGFBR2 NCOA1 SLC2A14 FGFBP1 SERPINB2 EDN2 SLC2A11 NCOA6 EGFR SLC2A10 TSC22D3 SLC2A13 PTGS2 SLC2A12 MYOF SLC39A11 SLC39A10 SLC39A13 SLC39A12 BAAT POU5F1 SLC7A5 B3GNT5 CDC42EP3 AHRR PMP2 ANGPTL4 MFGE8 HBEGF NR1I3 FGD4 TNF SRPX2 GPR153 SERTAD2 CAP2 CCL20 CAVIN2 PTGES3 GSTM2 NR1i2 NR1H4 CYP8B1 KTN1 FASN FABP1 GSTA5 GSTA4 SLC27A5 GSTA3 SLC6A3 SLC27A1 CDC37 NR3C1 SLC39A9 UGT1A1 EPHA2 SLCO2B1 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 DNER SLC39A3 AIP ALDH3A1 FGF8A SCNN1A FKBP5 NFKB2 SLC26A2 ABHD2 IP6K3 DNAJC15 SLC2A9 ALAS1 SRXN1 SLC2A6 SLC2A7 SLC2A8 ARL5B CPT2 ZIC2 ME1 PDK4 POLK ACADM SRGN GPX2 HEL-S-25 HEL-S-22 TGFBR3 DNAJC7 NAV3 ADGRF4 BIRC2 BIRC3 SLC5A12 SLC5A10 PRRG4 UGT1A4 STOM UGT1A7 TXNRD3 S100P SPRY1 ADH7 PCK1 KLK15 FGF13 HSP90AB1 ABCC5 SRC DBI CCL2 APOA2 PLTP CDKN1B IL12B SMC1A IL12A IFNG GADD45B CDC2 IL17B TGFB1 STAT3 PPP1R14C BAX ALOX5AP TXN SERPINA1 THBD APOC3 CPT1A ABCG8 ABCG5 SCD CYP7A1 GPAM SULT2A1 CYP1A2 CYP1B1 NR0B2 ABCB1 BHLHB2 SLC2A2 SLC5A1 SLC5A2 SLC6A20 SLC5A5 PPARGC1A EGR1 UGT2B4 SLC6A19 UGT2B7 ABCC2 SLC6A18 GSTM1 SULT1A1 SNAI2 SLC5A8 FOXO1 CDK4 TNFAIP3 NR1C1 MYC IL11 RXRA JUND NR1i1 HEL-75 GCLC NFE2L2 CYP2C9 RGS2 CYP2A6 CYP2B6 EHHADH IGFBP1 HES1 JUNB SLC7A11 FTH1 NR1H3 SLC39A8 GSTM4 KAT2B KEAP1 MAFG SLC39A14 FTL CDKN1C JUN HMOX1 SP1 MAFF GCLM PDE4B AMIGO2 PTPA IL1B NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP61%HOMO SAPIENS Notch signaling GSK3B HDAC2 EP300 STAT3 SKP1 SRC NFKB1 MAML2 SNW1 MAML1 FHL1 DTX1 RBPJ MAGEA1 CIRSR MTOR SPEN PIK3R2 SAP30 NCOR1 NOTCH2 PIK3R1 HES6 NCOR2 NOTCH3 NUMB NOTCH1 APH1B FBXW7 ADAM17 MAML3 JAG2 PSEN2 HDAC1 PSEN1 HEY2 HES1 DLL3 HES5 DLL4 PSENEN ITCH LCK DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260211%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MARCHF5 DNAJC19 TIMM8A TIMMDC1 USP9X STAT2 PYCR2 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 C1QBP AIFM1 MCL1 TRAK1 MFN2 PARK2 VCP UFD1L MIPEP UBXN1 CLPB TXN2 PLEK FLJ10842 MICOS13 OPA1 OPA3 GDAP1L1 TXNRD2 LONP1 SACS PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP TMEM126A YME1L1 MICU1 HTRA2 SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260211%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CDKN2A RELA ZAP70 IRF2BPL GRAP2 HLA-DRB1 TYK2 LTA PDPK1 LCP2 CARD11 BCL10 CCL19 MAPK1 PTPRC TNF HLA-DRA FYN MAPK3 CCL28 LAT RPTOR IL18R1 MAP2K1 NFKBIA DEPTOR CTLA4 MAP2K2 MLST8 BCL2L1 RAF1 CD80 RHEB IL12B IL12A IFNG IL23A PRKCQ CCND1 LCK IL17A GSK3B IL23R PIK3CD TSC2 MYD88 CD3G CD3E CHUK TSC1 CD3D BAX STAT4 IFNAR2 IKBKG PLCG1 IL12RB1 JUN NFATC1 IFNAR1 NFKB1 IL2 IL4 MTOR PIK3R1 ICOS FOXO3A FOS CDKN1A PTEN IFNB1 IKBKB PPP3CC RICTOR HRAS GRB2 SOS1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260211%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAG2 PRKAG3 PRKAA1 RHOB YAP1 RHO HMGCR CTGF PRKAB2 PRKAB1 LATS1 TEAD4 CYR61 PRKAA2 LATS2 ARHA STK4 TEAD2 RHOD TEAD3 MOB1A PRKAG1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260211%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 ACE2 AGTR1 AVPR1B ENDOMETRIAL CANCER%WIKIPATHWAYS_20260211%WP4155%HOMO SAPIENS Endometrial cancer EGFR BAK1 NRAS BRAF CTNNB1 PDPK1 MYC AKT3 ERBB2 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 HEL-S-28 CTNNA1 CTNNA3 EGF RAF1 CTNNA2 FGFR2 LEF1 DDB2 PIK3R3 TCF7L2 TCF7L1 GADD45B GADD45G CCND1 GSK3B PIK3CD POLK CASP9 ARAF BAX AXIN1 AXIN2 PIK3CA BAD GADD45A APC PIK3R2 PIK3R1 FGFR1 FOXO3A FGF2 FOS CDKN1A PTEN HRAS APC2 GRB2 SOS1 FGFR3 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260211%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK8 STAT2 MYD88 CHUK STAT1 TRAF3 TRAF6 TBK1 IFNAR2 IKBKG JUN TYK2 NFKB1 IFNAR1 MAVS RIGI MAPK14 NFKBIA TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 RIPK1 MAP3K7 FOS TICAM1 IKBKB JAK1 IFIH1 IRF3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDKN2A EGFR SMAD2 SMAD4 PAK1 BAK1 RELA STAT1 BRAF VEGFA TGFBR1 RAD51 CDK4 AKT3 ERBB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 TGFA BCL2L1 EGF RAF1 RPS6KB2 dik RAC3 E2F2 RPS6KB1 DDB2 PIK3R3 RB1 PAK6 PAK4 GADD45B TIAM1 GADD45G CCND1 PIK3CD MAPK10 POLK CASP9 MAPK9 MAPK8 TGFB1 CHUK STAT3 ARAF BAX IKBKG PIK3CA NFKB1 ARHA BAD MTOR GADD45A PIK3R2 PIK3R1 RALBP1 CDC42 CDK6 E2F3 HEL-S-34 CDKN1A RALB BRCA2 IKBKB RAC1 JAK1 TGFBR2 RALA TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260211%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TDO2 IDO1 GOT2 IFNA6 KYAT3 KYAT1 IL6 DDC IFNB1 IFNG AADAT IL1B HAAO TNF KMO KYNU AFMID IDO2 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP1591%HOMO SAPIENS Heart development MEF2C NKX2-5 SMAD4 FOXC2 FOXC1 VEGFA BMP4 SHH NFATC1 ISL1 PITX2 CTNNB1 FGF10 HAND1 GATA4 MAPK1 NFATC3 SMAD1 NFATC2 PTPN11 FGF8 NFATC4 ERBB3 NOTCH1 FOXA2 HEY2 BHLHB2 BMPR1A BMP10 GATA6 BMPR2 TBX20 SMYD1 TBX1 FOXH1 IRX4 TBX5 TBX2 HAND2 BMP2 VEGFB VEGFC SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4658%HOMO SAPIENS Small cell lung cancer ITGB1 LAMB3 LAMB2 PTGS2 BAK1 RELA TRAF3 CDK4 MYC AKT3 RXRA CDK2 NFKBIA NFKBIB BCL2L1 BCL2 CDKN1B ITGA2B E2F2 LAMC1 DDB2 CCNE2 PIK3R3 RB1 CKS1B CDKN2B GADD45B ITGA2 TRAF1 TRAF4 COL4A3 GADD45G CCND1 TRAF5 CKS2 CYCS RARB COL4A5 BIRC7 PIK3CD FHIT POLK RXRB CASP9 LAMA5 RXRG LAMB4 CASP3 CHUK APAF1 BAX TRAF2 TRAF6 IKBKG COL4A2 BIRC2 CDKN1C COL4A1 BIRC3 SKP1 COL4A4 PIK3CA COL4A6 NFKB1 MAX CASP8 NOS2 GADD45A PIK3R2 PIK3R1 LAMB1 CDK6 E2F3 LAMC2 CCNE1 ITGAV CDKN1A PTEN IKBKB ITGA6 LAMA1 LAMA4 LAMA3 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MMP9 MEF2D EZH2 SHC1 TWIST1 SOS2 PIK3R3 HIF1A COL4A3 COL4A5 MAPK8 SPARC TGFB1 TUSC3 HEL-S-79 FOXQ1 FZD10 CDKL2 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 TWIST2 JUP PALS1 VTN NRP2 PKD1 CLDN22 CLDN20 CLDN24 CLDN23 EED CLDN11 CLDN10 CLDN15 PIK3R2 CTDSP1 PIK3R1 CLDN14 CLDN19 STRAP CLDN4 CLDN18 CLDN2 CLDN17 CLDN16 TMPRSS4 FZD1 NR2C2 WNT10B SUZ12 WNT10A GDF15 FZD3 NUBPL CRB3 FZD2 FZD5 FZD7 FZD9 FZD8 TJP1 MMP2 LATS2 HRAS TGFBR2 MMP15 SMAD2 SMAD4 PAK1 ID2 CDH2 FOXC2 ID1 SNAI1 FMNL2 SNAI2 FOXM1 TGFBR1 WNT7B WNT7A CTNNB1 CLDN1 AKT3 MAP2K3 MAP2K4 MAPK1 MAPK12 KRAS MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 RAF1 ZEB2 PROX1 WNT1 WNT3 WNT4 RBBP4 WNT3A GSK3B WNT2B PIK3CD TRAF6 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA LRP5 CLDN6 LRP6 RBPJ CLDN5 JAG2 FZD4 WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 GRB2 SOS1 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260211%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 CYB TTC19 UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCC UQCRC2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260211%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system MAP1B BIRC5 TUBA2 MYH9 ERG EGFR SMAD2 STUB1 MAPRE1 AURKA HEL113 CFTR HDAC11 ITIH4 EP300 NEDD9 HTT KALRN ATXN3 ADRBK1 EP400 CCDC141 SHH POU5F1 FUS BDNF MIIP TARDBP ARID3A ISG15 BBIP1 CTNNB1 GARS1 CNOT6 HEL-S-2a HDAC9 TWIST1 MAPK1 HDAC6 MAPK3 MAP3K5 HEL-S-44 CYBB BCL2 GRIA2 NR3C1 PXN PRKCE MAP1LC3A SQSTM1 OPTN HIF1A HEL-S-102 PTK2B HEL-S-32 MIF GSK3B DCTN1 PRKCZ MAPK8 RHOT1 MYD88 BAX PARK2 KAT5 VCP HSF1 CSNK2A2 FOXP3 TUBA1C DLG4 SP1 SGK1 CSNK2B VHL APC TUBB HEL-S-72p APOE TUBA4A HEL-S-67p GSK3A SNCA HSPA4 DLG2 RAC1 IKBKAP CDC20 FREP1 SNCAIP CD133 FAT10 SIRT2 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260211%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 EGFR PRL CHUK CEBPA PRLR NFIA CEBPB TFPI2 MYC CSN2 ERBB2 NRG1 CLDN6 YY1 ERBB4 DLGAP4 PTPN1 USF2 TTC9 NR3A2 GJB2 GAL ERBB3 NFIB ELF5 BCL2L1 EIF4E ORAI1 PGR HDGFL2 USF1 EIF4G1 TNFSF11 TPM3 NR3C1 TNFRSF11A STAT5B CCND1 TP53 NETWORK%WIKIPATHWAYS_20260211%WP1742%HOMO SAPIENS TP53 network BCL2 CDKN2A SUMO1 TNFSF10 TP73 BBC3 OTX2 BAX BOK MDM2 ATM CDKN1A MYC PMAIP1 GADD45A TP63 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NFKB1 SP1 MAPK1 MAPK3 RBPJ TLR9 CYBB CDC42 NOTCH1 NCF2 DOCK6 CYBC1 NCF1 NOX3 NCF4 COX4I2 CXXC5 DGUOK CHCHD2 KCNN3 C4orf54 DLL4 GTF2I BEND6 EFL1 CYBA SHCBP1 RAC1 IBTK ARHGAP31 EIF6 SBDS BTK TLR8 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP1 SP3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260211%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ADCY3 ADCY8 SLC16A10 SHH FOXO1 SRC KDM1A CTNNB1 AKT3 RXRA MAPK1 ATF2 RPTOR MAP2K1 MAPK14 MLST8 NOTCH1 RAF1 ITGB3 RPS6KA6 RPS6 RPS6KB1 RHEB AKT1S1 WNT4 THRA AQP7 GSK3B TRH TTF2 TTF1 NPPB ITPR2 MC4R CASP9 NHSL1 TSC2 DUOXA2 SLC16A2 TSC1 TBC1D4 TSHB ACTL6B SECISBP2L DIO1 SIRT6 SLCO1C1 ADRB3 PAX8 PIK3CA MAPKAPK3 ZNF516 PLIN1 PFKFB2 MGLL KDM3B AgRP UCP1 NR1A2 PRDM16 DUOX2 DEHAL1 NPY BAD MAFA FGF21 TSHR MTOR TG SLC26A4 TPO PNPLA2 POMC PPARG FGFR1 MDM2 ITGAV CREB3 FRS2 SLC5A5 PPARGC1A HRAS GRB2 SOS1 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260211%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAPK10 MAP2K5 MAPK9 MAPK8 RPS6KA2 CSNK2A1 PIK3CA AKT3 MAP2K3 EIF4EBP1 MAPK1 MAP2K4 MAP2K6 MAPK3 RPTOR MAP2K1 MAPK14 MTOR MAP2K2 PIK3R2 EIF4A2 PIK3R1 EIF4A1 PIM1 EIF4E PIM2 EIF4B RPS6KB2 EIF4G1 RPS6KA4 RPS6 RPS6KA5 RPS6KA1 RPS6KB1 PIK3R3 PRKCA THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260211%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling MAPK9 MAPK8 RELA STAT1 STAT3 RELB STAT4 GAB2 SRC NFKB1 EIF4EBP1 MAPK1 FYN MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA LYN MAP2K2 TEC YES1 IL7R TSLP FES CRLF2 RPS6 NFKB2 JAK1 STAT5B BTK LCK SPINA BIFIDA%WIKIPATHWAYS_20260211%WP5150%HOMO SAPIENS Spina bifida MAT1A MTRR MTR AHCYL2 MTHFD1 SHMT1 DNMT3B 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome SLC35G3 RPL23 SRCIN1 SLFN12 CACNB1 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 TCF2 SLFN5 CCL13 GRB7 CCL11 GGNBP2 CCL3L3 FBXO47 MLLT6 FBXL20 NEUROD2 MIEN1 CCL8 CCL5 ERBB2 CCL7 ZNHIT3 LYZB C17orf78 CCL2 CCL4 CCL1 ASIC2 TEC CCL18 RFFL GAS2L2 SOCS7 ACACA CCL16 LHX1 HEATR9 CCL15 TAF15 TMEM132E RASL10B PCGF2 SYNRG EPOP FNDC8 PEX12 PLXDC1 NLE1 ARHGAP23 TBC1D3K STAC2 TCAP CDK12 SPMAP1 PIP4K2B PNMT PPP1R1B DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I MRM1 AATF IKZF3 MMP28 CISD3 DUSP14 TBC1D3H CCT6B RDM1 ARL5C C17orf50 GPR179 STARD3 UNC45B MED1 CCL3 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 HEL-S-130P PDX1 CTNNB1 MSRA GATA4 MAPK1 MAPK3 NKX6-1 SLC2A4 RAF1 BMP1 MTMR8 MTMR9 NUMA1 MTMR6 TERT PINX1 HEPACAM2 TBX5 SOX7 SLC35G5 PRSS55 NEIL2 BLK CSTA MCRS1 TNKS PRSS51 S100A10 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 FAM167A FCGR2A FCGR2B AXIN1 XKR6 PPP1R3B FDFT1 CLDN23 SLBP ERI1 TERF1 SGPL1 CGAS HSPD1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5402%HOMO SAPIENS 10q22q23 copy number variation CEBPA VEGFA ERBB4 MGRA ADAM10 SMC1A MAT1A BMP2 SH2D4B FAM25A BUB1B SMC3 ADIRF LDB3 GHITM IQUB WAPAL NFKB1 ROPN1L RSPH6A ACTN2 SIRT4 DNAJB13 NME5 NRG3 CDHR1 MMRN2 SH3GL3 DYDC2 DYDC1 ZMYND11 RGR RSPH9 PDS5B PDS5A GPR15LG RAD21 SNCG TNFSF11 GPR15 PPARG SUSD2 RSPH3 GLUD1 MAD2L2 STAG1 TSPAN14 RSPH1 LRIT2 SHLD3 BMPR1A LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 OPN4 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 RPE PRPS1L1 DERA OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260211%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators MMP9 CNTF CXCL2 CCL14 CCL13 CCL23 CCL11 CCL3L3 LIF LTA CX3CL1 CCL8 CCL5 CCL19 CCL7 CCL28 CCL2 CCL4 CCL1 CCL18 CCL16 CCL15 IL25 IFNA6 IL12B TNLG7A IL12A IFNG IL23A IL17F IL17D IL17C IL17B IL17A IF2B1 IL15 IL-21 TGFB1 CXCL12 IL10 IL13 IL2 IL4 IL5 CXCL8 SPP1 IL3 IL9 CSF2 MMP3 IL1RN CXCL17 CXCL13 IF2D CXCL11 CXCL14 IF2G IL36A IL1A IL36B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 EBI3 IL36RN IFNA21 IF1AA9 TNFSF13 IL36G PPBP VEGFA IFNW1 IL1F10 CXCL6 IL24 IF1IB1 IL27 CXCL3 IL7 IFNA8 CSF1 PF4V1 IL11 IL19 XCL2 TNF IFNK XCL1 CTF1 IFNL2 IFNL3 CCL17 CCL20 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 IFNA7 OSM CSF3 EPO NFKB1 IL6 IFNA2 CXCL5 TSLP CXCL16 CCL4L2 IL18 IFNB1 IL1B CXCL9 IFNA1 CXCL1 AREG CCL3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis BCL2 FADD CASP9 CASP3 BAK1 APAF1 DIABLO BAX TNFSF6 CASP6 PRF1 FAS HTRA2 CASP8 AIFM1 CYCS TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP107%HOMO SAPIENS Translation factors EIF1AX EEF2 EIF2S2 SUI1 EIF3S3 EEF2K EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF4EBP1 EIF4A2 EIF4A1 EIF4E EIF4B EIF4G1 GSPT2 EEF1B2 EIF4H EIF4EBP2 EIF4EBP3 EIF2AK2 EIF2B1 PAIP1 EIF5A EIF5B EIF2B3 CLUH EIF2B2 EIF1AY EEF1A1 EEF1G EIF2AK1 EIF6 EEF1A2 EIF2B5 ETF1 EIF2S1 PABPC1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT3 MTOR 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260211%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4E PIK3CD RAF1 TSC2 PRKAA1 TSC1 PIK3CA PIK3R3 MAP2K3 EIF4EBP1 MAPK1 MAP2K6 MAPK3 MAP3K5 MAP2K1 MTOR MAP2K2 HEL164 PIK3R2 MAP3K11 PIK3R1 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260211%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 H3Y2 DUX4 MYF5 EP300 VEGFA PAX7 TRIM63 ADRB2 CDKN1A MYC FBXO32 PPARGC1A NR3A2 MYOD1 MYOG RET H3Y1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2853%HOMO SAPIENS Endoderm differentiation TAF5 MIXL1 HOXA1 EZH2 PAX3 RGS10 CTBP2 GATA4 ZIC5 LHX1 ELAVL1 SESN1 LAMC1 GATA6 TCF4 C1QBP FOXH1 SOX7 PLCH1 APP TGFB1 TBX21 CRTC1 PIAS1 NABP2 DKK1 DNMT3B MAD2L2 BMPR1A NKX2-1 CAND1 SIAH2 SMAD2 SMAD4 SLC2A12 STAT1 TET1 TCF2 FOXO1 POU5F1 SFRP1 CUL4B CTNNB1 MAP2K3 SOX2 FOXA1 NOTCH1 ACACA BMP7 OTX2 FOXA2 NR3C1 LEF1 PTHLH TCF7L1 WNT3 PABPC1 WWC1 SOX21 SOX17 CEP250 CER1 WDHD1 SFMBT1 CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 BCORL1 TOX CTR9 PRDM14 RTF1 NLK MBTD1 EPB41L5 UBR5 BPTF CEBPZ ATP8B2 PBX3 FOXN3 GDF3 DUSP4 APC ZFHX4 TRERF1 PBX1 EXT1 SP4 PAF1 TAF4B NODAL TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 JARID2 DUSP5 VAV3 DUSP2 WNT8A NOG PARP8 NR1B3 TOX3 AEBP2 Pax9 AHDC1 BTAF1 TCEAL2 LEO1 KDM4A ZNF462 ELP4 LRPPRC TNRC6C ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway PLAGL1 EGFR CD36 KLF6 NCOA7 PTGS2 RELA EP300 NRAS VEGFA SRC NFKB1 AHRR MYC CDK2 MAPK1 TNF KRAS FGF21 CCL1 MAP2K1 NCOR2 GCLC RAF1 NFE2L2 CDKN1B LPL NQO1 CYP1A2 NF1 CYP1B1 CDC37 CYP1A1 AIP CDKN1A RB1 HRAS AHR RET GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260211%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG INS IL6R IL6 GLP1R SLC2A2 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP INSR STAT3 LEPR INS PDPK1 PIK3R3 SOCS2 DGKZ SOCS3 SOCS1 IRS1 IRS4 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260211%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 REN MGRA ACE2 AGTR1 DRAVET SYNDROME%WIKIPATHWAYS_20260211%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A SCN8A PRR5 MAPKAP1 KCNA2 CHD2 PCDH19 SCN3B SCN3A SCN1B SCN1A PIK3CA SNTA1 NFKB1 SCN2A SCN4B SCN2B HCN1 TNF MAPK11 MTOR STXBP1 MLST8 CALM1 FGF13 PRKCA RICTOR S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB1 PLCB2 GNAI1 S1PR3 PIK3C2B GNAI3 SPHK2 SPHK1 MAPK7 PLCB3 AKT3 MAPK6 SMPD2 MAPK1 S1PR2 MAPK4 MAPK12 S1PR5 MAPK3 S1PR1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome MEF2C CAMK2A TET2 CNP CTCF TET1 MBP EZH2 IGF1 FUS IGF1R CEBPD BDNF TARDBP GRIN1 DLX5 PSIP1 YBX1 CDON RBFOX1 HEL-S-20 TAP1 NCOR1 POU3F2 HNRNPH1 GPRIN1 TET3 DLX6 FOXG1 NREP FUT8 PRPF38A RPS6 GAD1 HDAC1 GRIA3 IGF2 GRIA4 POU4F1 SST HNRNPF TAF1 FKBP5 REST SP3 BCL6 MYT1 SMC3 UBE3A SP1 SGK1 APOC2 MTOR OPRK1 NF1 FGF2 FGF7A PTEN CREB1 FGF5C SIN3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SC5D DHCR7 HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260211%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB COL5A3 COL5A2 LAMB2 COL3A1 ITGB5 COL4A2 COL4A1 LAMC1 ITGB6 THBS1 SDC2 ITGA1 COL6A1 LAMA4 COL1A2 THBS2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260211%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling GSK3B PDHA1 CYP24A1 TSC2 TSC1 RELA CD80 IL10 SLC2A3 PIK3CA IL12A MYC PFKFB4 HEL-S-133P RXRA PRKAA2 NR1i1 HK3 HLA-DRA MTOR NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260211%WP4747%HOMO SAPIENS Netrin UNC5B signaling CIP2A RGMA DCSTAMP MYF5 COL1A1 CASP3 YAP1 CTGF IL10 JUN NEO1 SRC PIK3CA KDR AGAP2 MAPK1 TNF ARHA FYN MAPK3 INPP5D CCL2 PTPN11 MAP2K1 MAPK14 MAP2K2 SELE PPP2R1B RAF1 ALPL ITGB4 PRKCA PTPA RAC1 ROBO4 NTN1 PTK2B RLF NTN3 PLEKHH1 ARHGEF12 VCAM1 UNC5B IL1A HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260211%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260211%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex HLA-DRB5 NRF CD8B1 CD3G PRG3 CD3E CD2 IGLL1 CD8A CRP LBP ZAP70 MMP25 HLA-DRB1 IL6 CXCL8 HLA-DRA FYN LCK FANCONI ANEMIA%WIKIPATHWAYS_20260211%WP5465%HOMO SAPIENS Fanconi anemia EGFR MRE11A DCLRE1B CTDP1 UHRF2 FAAP24 CEBPD BRIP1 RAD50 SLX4 RAD51 MEN1 FANCM CENPX FANCL REV1 UBE2T FANCA FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C FANCD2 RFWD3 ERCC1 HEL-S-125m CENPS MCM2 SMARCA4 FAN1 MAD2L2 ATM NBN ATR UHRF1 PTEN BRCA1 BRCA2 USP1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IRAK1 PDLIM7 MAPK8 CHUK RELA TRAF6 IKBKG MAP3K7 NFKB1 TRADD NFKB2 IFNB1 CXCL8 IKBKB CCL5 MAPK1 TNF MAP3K14 TRAF1 NFKBIA CCL20 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260211%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA MAFG FBL CREBBP IRF2 SMAD4 HEL23 DDX21 CREB1 FOXO1 NPAS2 P38 MAPK SIGNALING%WIKIPATHWAYS_20260211%WP400%HOMO SAPIENS p38 MAPK signaling MEF2D STAT1 TRAF2 MAP3K1 TGFBR1 SHC1 MAX MYC MAP2K4 DDIT3 MAP2K6 MAP3K5 ATF2 MAPK14 SMIM40 CDC42 RASGRF1 HMGN1 MAPKAPK5 RPS6KA5 RIPK1 MAP3K7 TRADD CREB1 RAC1 HEL-S-102 HRAS GRB2 MAPKAPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHS1 ACSL5 ACSL3 ACACA FASN PECR MECR PC ACSS2 ECHDC1 ECHDC2 DECR1 ACLY ACACB SCD ACSL1 ACSL6 FACL4 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260211%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway MASP2 HEL-S-62p C3AR1 FCN1 C6 C7 COLEC11 C9 ACE2 C5AR1 C8A ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TSLP IL2RG CRLF2 STAT3 IL25 FCER1G IL13 IL1RL1 FCER1A TYK2 MS4A2 IL13RA1 IL4 IL5 OSMR JAK3 IL33 METHYLATION PATHWAYS%WIKIPATHWAYS_20260211%WP704%HOMO SAPIENS Methylation pathways MAT1A NNMT TPMT INMT PNMT METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer ME1 BCAT2 HMGCR PFKL ACLY SLC7A5 DLD SOAT1 KRAS HEL-S-30 HK2 GNPNAT1 PDHA1 LDLR GOT2 FASN CS GLUD1 PDHX RPIA GLS2 RPE PGM3 HEL-S-133P DLAT GPT SLC16A4 CARM1 HEL-S-32 GFPT1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260211%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260211%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAG2 PDHA1 ACACA FASN PRKAG3 PRKAA1 LIPE PRKACG ACSS2 PRKAB2 ACLY PRKAB1 HILPDA PLIN1 AKT3 PRKAA2 PRKAR1B PRKAR1A ABHD5 PNPLA2 PRKAG1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260211%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TLR4 IRAK4 IL2RG TGFB1 STAT3 CD80 TRAF6 NFKB1 IL4 NFKB2 SOCS1 CCL5 CCL2 TGFBR2 CTLA4 IL2RA TLR8 TLR7 IL2RB PDCD1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260211%WP5572%HOMO SAPIENS Nucleosome remodeling complex PCNA PRKDC CHAF1B NASP MCM2 HAT1 ASF1A ASF1B H4C9 HIST1H4L CHAF1A RBBP4 SUPT16H XRCC5 SMIM40 SSRP1 CHEK2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260211%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 CYP2A6 XDH CYP1A2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260211%WP4666%HOMO SAPIENS Hepatitis B infection TLR4 MMP9 IRF7 CREBBP STAT2 EP300 EGR2 SRC TYK2 SOS2 NFATC3 NFATC2 NFATC4 IKBKE IFNA6 MAP3K7 DDB2 PIK3R3 STAT5B PTK2B JAK3 MAPK10 MAPK9 MAPK8 TGFB1 STAT3 ARAF BAX STAT4 NFATC1 CXCL8 CASP8 VDAC3 PIK3R2 PIK3R1 FADD IKBKB CASP12 JAK1 HRAS IFIH1 TGFBR2 IRF3 TLR3 IFNA13 BIRC5 IFNA14 IFNA16 SMAD2 IFNA17 SMAD4 IFNA10 TICAM2 HSPG2 RELA STAT1 IFNA21 DDX3X TRAF3 IF1AA9 CASP10 BRAF TIRAP NRAS DDB1 MAP3K1 TGFBR1 MAP3K7IP1 FAS MYC IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 KRAS MAP2K6 MAPK3 MAPK13 ATF2 MAPK11 MAP2K1 MAPK14 MAP2K2 BCL2 RAF1 CREB3L3 CREB3L4 TNFSF6 PRKCB IFNA7 TICAM1 PRKCA CYCS ATF4 IRAK1 PIK3CD IRAK4 CASP9 MYD88 CASP3 CHUK APAF1 TRAF6 TBK1 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD PCNA YWHAQ HEL-S-1 CREB3L2 FOS YWHAZ CREB3 CDKN1A IFNB1 CREB1 CREB5 IFNA1 GRB2 SOS1 ATF6B NEPHROTIC SYNDROME%WIKIPATHWAYS_20260211%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A5 MYH9 LAMB2 MYO1E SCARB2 SMARCAL1 CD151 HEL-S-47e PTPRO COL4A4 GPC5 APOL1 TRPC6 SYNPO YARS EMP2 ALG1 WDR73 COQ6 ARHGAP24 COQ2 PAX2 WT1 CD2AP INF2 NPHS1 CTLA4 CYP11B2 PLCE1 ACTN4 NPHS2 COQ8B LMX1B E2F3 ITGB4 ZMPSTE24 LMNA CUBN COL4A3 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260211%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 THRAP3 MORC3 ELL BCLAF1 SETX STK38 TRIM35 RBBP7 SUZ12 EZH1 EZH2 JARID2 AEBP2 RBBP4 EED COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260211%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F2 HEL-S-78p F13B PLG F13A1 FGA BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260211%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260211%WP5236%HOMO SAPIENS Markers of kidney cell lineage TNC REN TCF2 BMP4 SFRP1 DKFZp781O1323 KDR PAX2 WT1 RSPO1 NPHS1 NPHS2 NOTCH2 NOTCH1 LHX1 HNF1A tmp_locus_29 BMP7 NR2A1 CITED1 TCF21 SALL1 SIX2 RSPO3 DACT1 EMX2 FOXD1 OSR1 KCTD1 ALDH1A2 PECAM1 TSHZ3 EGLN1 EGLN3 KIT EGLN2 EYA1 WNT4 TBX18 NTN1 GDNF TLX1 FAT4 DCN VSX2 ACTA2 EPO AXIN2 SIX1 SMAD1 FGF7 FGF8 PBX1 NT5E IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 IDO1 GOT2 IFNG AADAT TNF KMO KYNU KYAT3 KYAT1 IDO2 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 CYP1A2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260211%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 EGF PGR FOSL1 MYC HEL113 ERBB2 CCND1 TIMP1 AREG HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOC RBX1 CBFB NAE1 UBA3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260211%WP5598%HOMO SAPIENS Sodium channel in epilepsy GSK3B PTPRN CAMK2A SCN11A PDCD10 SCN7A SCN8A SCN5A PRRT2 MAPK8IP2 SCNM1 SCN4A RNF121 NEDD4 SCN3B SCN3A WEE1 SCN1B SCN1A SCN2A SCN4B SCN2B TNF FYN FGF14 CALM1 FGF13 FGF12 PSEN1 SCN9A BACE1 SCN10A ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260211%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260211%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BIRC5 CDKN2A BAK1 TRAF3 CASP10 FAS MAPK3 MAP3K5 NFKBIA BCL2L11 SMIM40 BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO PIDD1 TNFSF6 CASP6 RIPK1 AIFM2 IL1R1 PMAIP1 TNFRSF10B AIFM1 BLK PRKD1 MCL1 CYCS IRAK1 BIRC7 TNFRSF10A CASP9 MAPK8 MYD88 CASP3 APAF1 BAX TRAF6 HRK TNFRSF6B BIRC2 CAPNS1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 PTRH2 MADD TNFRSF25 NAIP BCL2A1 BCL2L10 CASP8 BAG3 MAP3K14 BMF CRADD BAD BIK BNIP3 TNFRSF10C SEPTIN4 PTPN13 TNFRSF10D BCL2L2 FADD FOS TRADD IKBKB TNFRSF1B HTRA2 IL1R2 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP268%HOMO SAPIENS Notch signaling CREBBP HDAC2 CTBP2 MAML1 DTX1 RBPJ NOTCH2 NCOR2 NOTCH3 NUMB NOTCH1 APH1B ADAM17 MAML3 RBPJL JAG2 CTBP1 DTX2 DTX3 PSEN2 DTX4 LFNG KCNJ5 HDAC1 DTX3L PSEN1 KAT2A MFNG HES1 DLL3 DVL1 HES5 DLL4 DVL2 DVL3 KAT2B METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260211%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX12 PTGS2 ALOX5 ALOX15 FADS2 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260211%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDK2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 RPTOR MAPK11 MAP2K1 MAPK14 MAP2K2 PRKAG1 MLST8 PRKAG2 PRKAG3 PRKAA1 PRKAB2 RPS6KB1 PRKAB1 CDC2 EEF2 EEF2K MTOR CALM1 UQCRB COX7C RPS6KA1 RAB5IF MOSMO UQCR11 NDUFS8 UQCR10 CYB NDUFS3 COXFA4 CDH18 UQCRH COX5A UQCRQ TRPM7 UQCRC1 PDZD9 UQCRFS1 CDR2 CYC1 NDUFA9 SDR42E2 UQCRC2 VWA3A POLR3E FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260211%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 RPS6KB2 TSC2 FSHR RPS6 RPS6KB1 FOXO1 RHEB SRC PRKCA FSHB CREB1 EIF4EBP1 MAPK1 SGK1 MAPK3 H3-4 APPL1 MAPK14 MTOR CGA PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling MMP9 BIRC5 PTGS2 RELA CHUK CXCL2 RELB TRAF6 VEGFA BIRC2 BIRC3 TNFRSF1A NFKB1 IL2 IL6 CXCL8 BCL2A1 TNF SELE BCL2L2 NFKB2 CD40LG IKBKB EGLN2 MMP2 IL1B CSF2 MMP3 REL CCND1 VCAM1 IL1A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260211%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP2C8 NR1C1 PPARG CYP4F2 CYP4A11 CYP4F12 CYP2C18 EPHX2 CYP4A22 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260211%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C2 NR1C1 CD36 CYP2C9 NR1i1 NPC1L1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260211%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A ADCY1 ADCY8 GNAI1 ARAF PPP1R1A GRIN1 PPP1CC RAP1A HEL-S-80p MAPK1 MAPK3 GNAS MAP2K1 MAP2K2 GJB1 CALM1 RAF1 ACTG1 GRIA2 GRIA3 PS1TP5BP1 PRKACG GRIA4 PRKCB PRKCA DRD1 DRD2 CREB1 DRD4 ACTG2 CAMK4 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 UGT2B7 AKR1D1 AKR1C1 AKR1C4 AKR1C2 UGT1A10 CYP11B2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260211%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PLCB4 PLCB1 CACNA1A PLCB2 GRIA2 GNA14 RYR3 HOMER3 CA8 GRIA3 GRIA4 GNA11 TRPC3 GNA15 PLCB3 ATP2B2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260211%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 NFKB1 TGFB1 RASGRF1 STAT3 MYEF2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260211%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling GSK3B MAPK9 MAPK8 CASP3 RELA CHUK TRAF3 RELB TRAF2 BIRC2 BIRC3 JUN NFKB1 CTNNB1 MAPK1 TNF CASP8 MAP3K14 MAPK3 MAPK14 NFKBIA NFKBIB FADD RAF1 HDAC1 RIPK1 MAP3K7 TWEAK TRIM63 TNFRSF12A NFKB2 IKBKB RAC1 TRAF1 TRAF5 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260211%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP9 SMAD2 CACNB1 SMAD4 MCUB SCX TOMM20 SLN TGFBR1 SGCA CAPN3 TRPC1 TRDN STIM1 CASQ1 TNNI1 DMD CACNG1 PRKAA2 PLA2G2A TNF FKBP1A SSPN SNTB1 NFKBIA AGTR1 CYBB ORAI1 PPIF CACNA2D1 PRKAA1 MPO CACNA1F FGA HEL-S-78p CACNA1S MCU DAG1 ATP2A1 ITPR2 CASP9 TGFB1 PRG3 CTGF IL10 TRPC6 SLC25A5 NFKB1 TRPC3 IL6 SPP1 NOS2 ELANE RYR1 SIGMAR1 NOX4 MMP2 IL1B CAMK2D TGFBR2 IL1A CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260211%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2C TLX2 MEF2B KLF4 ID2 MEF2D STAT3 RUNX2 EZH2 PAX7 HDAC5 LEFTY1 TLX1 SOX2 TLX3 MYOD1 LEFTY2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260211%WP3972%HOMO SAPIENS PDGFR beta pathway RAF1 MAPK8 STAT1 STAT3 MAP3K1 PLCG1 JUN PRKCB EIF2AK2 PIK3CA SHC1 FOS PRKCA MAP2K4 STAT5B MAPK3 JAK1 HRAS MAP2K1 GRB2 SOS1 PIK3R1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT2B MAPK10 MAPK9 MAPK8 WNT7B WNT16 WNT7A CTNNB1 LRP5 LRP6 ARHA INVS WNT5B NPHP3 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT9B FZD7 FZD9 FZD8 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260211%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A ID2 ARCN1 ID1 USP1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260211%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia GSK3B FLT3 ZBTB16 PYGO1 BCL9 WIF1 SALL4 RARA RUNX1T1 LEF1 PML CSNK1A1 AXIN2 NR1C2 JUP CTNNB1 TCF3 DKK1 MYC LRP5 WNT1 LRP6 CCND1 APC SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260211%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK GPX2 RELA DIO1 JUN NFKB1 TXNRD3 SP1 GPX1 CTH FABP1 NFE2L2 RPL30 HEL-S-134P SELENOF GPX3 SELENOI TXNRD2 SELENOH SEPHS1 CREM SEPHS2 PSTK EEFSEC POU2F1 GPX6 FOS TRNAU1AP SELENOO SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SELENOW GPX4 SELENOV SELENOT SP3 MSRB1 SELS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260211%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias FECH UROD UROS HMBS CPOX ALAS1 ALAS2 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EGFR ADAP2 HOXA1 MAP3K1 RAD51 OMG MAPK1 MAPK3 SUPT5H BCL2 EGF CRY1 RAF1 RBBP7 EZH1 CCNA2 CCNE2 SDC2 MCL1 PER1 RTN4R HEL-S-15 RAD9A WDR48 NGFR HOXA9 H3C8 EXOC8 EXOC7 RFC2 MYT1 ARF6 POLRMT EXOC4 EXOC3 MAP3K2 EXOC6 ROCK2 RFC3 EVL RFC4 EXOC5 EXOC2 EXOC1 H3C15 INPP5A E2F6 RAB11FIP4 TEFM UTP6 LIMK1 MAVS ATAD5 ARHA RAB11A RIGI EED COPRS EVI2A CRLF3 EVI2B METAP2 PCNA TUBB SUZ12 NF1 CCNE1 JARID2 H4C9 ATR HIST1H4L NGF IFNB1 USP1 SYN1 SOS1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 LEP ACACA ADIPOR1 ADIPOR2 PRKAA1 CPT1A LEPR PRKAG1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260211%WP2361%HOMO SAPIENS Gastric cancer network 1 NUP107 NOTCH1 HCTP4 GATD3 KIF15 AURKA SMOC2 CENPF ESM1 RUVBL1 MYBL2 ECT2 KIF20B E2F7 TOP2A H4C9 UBE2C ACTL6A S100P CEP192 H3F3B LIN9 APC INO80D VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260211%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F2 F7 PROC AIFM2 NQO1 PROS1 VKORC1 UBIAD1 F10 F9 GGCX PROZ 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5406%HOMO SAPIENS 13q12 12 copy number variation DAG1 MAPK9 MAPK8 TRAF3 TRAF2 SGCA SNTA1 LINGO1 DMD ARHA SSPN SNTB1 CDC42 MIPEP SACS RTN4 C1QTNF9 SGCD ATXN1 SGCB SGCG TNFRSF19 C1QTNF9B SPATA13 RAC1 TRAF1 TRAF5 RTN4R TNF ALPHA SIGNALING%WIKIPATHWAYS_20260211%WP231%HOMO SAPIENS TNF alpha signaling CREBBP NRAS MAP3K1 MAP3K7IP1 KSR1 TNFAIP3 SMPD2 MAP2K3 MAP2K4 MAPK1 TNF KRAS MAPK3 MAP2K6 MAP3K5 NFKBIA RFFL NFKBIB BCL2L1 RAF1 DIABLO CDC37 MAP3K8 RIPK3 MAP3K7 RIPK1 NFKB2 CYBA REL TRAF1 PPP2CA TANK CASP9 PRKCZ MAPK9 TAB3 PIG59 MAP4K2 MAPK8 CASP3 CHUK APAF1 BAX TRAF2 TBK1 IKBKG BIRC2 BTRC BIRC3 SKP1 JUN CSNK2A1 TNFRSF1A TXN NFKB1 MADD CASP8 MAP3K14 FBXW11 BAD PSMD2 PLK1 FADD TRADD IKBKB TNFRSF1B OTUD7B RAC1 PYGL HRAS KSR2 PTPRCAP NSMAF GRB2 NFKBIE SOS1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence CYP4F8 SLCO2A1 HEL-S-53e DPEP2 ALOX12 LTC4S NAT2 PTGS2 ALOX5 HEL-S-22 ALOX15B ALOX15 ALOX5AP GPX1 FADS2 MAPK11 EPHX2 PTGES3 FADS1 ELOVL5 SIRT1 HEL-S-298 HPGD AKR1B1 DECR1 PTGS1 CDKN1A RB1 PTGIS PRXL2B ALOXE3 ELOVL2 PTGES PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway WNT2B TF NTF4 FST CNTF FLT3LG KITLG TGFB1 INHBA GDF5 EPO PDGFA IGF1 VEGFA BMP4 SHH WNT7B ALK INS FGF10 CSF1R HGF DKK1 IL6 CSF1 IL11 LEFTY1 FGF8 TPO IL3 NOTCH1 EGF TNFSF11 NODAL FGF2 FGF7A NOG IL6R WNT1 KIT NT5E CXCR1 WNT3A FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260211%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IRAK1 TLR4 IRAK2 IRAK4 MYD88 TICAM2 RELA CHUK LY96 LBP TIRAP TRAF6 IKBKG SRC PIK3CA NFKB1 CXCL3 IL6 TNF ARHA NOS2 CCL2 SYK ITGAM PLAT PLG FGA IL12B FCER1G TICAM1 HEL-S-78p IFNB1 IKBKB REL TYROBP IRF3 CD14 TLR3 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260211%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1 GYS2 GYS1 HEL-S-19 PYGL AKR1B1 SLC2A2 GYG1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260211%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BIRC5 SMAD2 SMAD4 PTGS2 BAK1 DCC BRAF MSH3 TGFBR1 CSNK1A1 CTNNB1 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 BCL2L11 BCL2 RAF1 BBC3 LEF1 RAC3 DDB2 TCF7L2 TCF7L1 PMAIP1 REL GADD45B NTN1 GADD45G CCND1 CYCS GSK3B MAPK10 POLK CASP9 MAPK9 MAPK8 CASP3 TGFB1 ARAF BAX AXIN1 TBK1 AXIN2 MSH6 JUN MSH2 EXOC2 ARHA BAD GADD45A APC CSNK1A1L FOS CDKN1A RALB RAC1 APPL1 APC2 TGFBR2 RALA PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260211%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1A2 CAMK2A PDE3B ADCY3 ADCY1 ADCY8 PDE4A ADCY6 PDE3A GUCY1B1 PDE1C PDE1B PDE1A HEL-S-7a GRIN1 PDE11A PPP1R1B PDE6D PDE6C PDE6A PDE8A PRKG1 PDE6H PDE6G PDE2A PDE10A PDE12 PDE5A PDE7B PDE7A ADORA2A PDE9A CHRNA7 PDE4B PDE4D GRIN2B DRD1 DRD2 CREB1 ADCY9 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260211%WP1422%HOMO SAPIENS Sphingolipid pathway CERS5 PLPP1 ACER1 SPTLC3 CERS2 SERINC1 CERT1 ASAH2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 PPP2CA KDSR VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260211%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREBBP HLX TRPC1 KDR HEL-S-68p GATA2 ACKR3 PDPK1 PRKAA2 SHC2 MLST8 VPS39 EIF4E TPM3 ADAM10 RPS6 NCL RPS6KB1 PTMAP7 PLA2G5 PXN AKT1S1 ACACB SARS1 CAMKK2 SDCBP PTK2B CCND1 OCRL TBCA EIF3S3 HEL-S-162eP NFATC1 EIF3F EIF3D DKK1 RAP1A CXCL8 CYR61 RAB11A MMRN2 PIK3R2 PIK3R1 RAPGEF1 FADD MDM2 HEL-S-128m NOX4 TEAD4 PPP3CA MMP2 RAC1 HRAS ANXA1 MMP10 SLC2A14 MMP14 ABCF2 PAK1 PTGS2 RELA STAT1 VEGFA FAS CTNNB1 HMGB1 HBEGF MAP2K3 PRKG1 MAP2K4 MAPK12 MAP2K6 MAP3K5 GPX1 MAP2K1 MAPK14 MAP2K2 CYBB RAB5A ERN1 BCL2L1 ACACA RAF1 RPL5 HEL114 RPL7 RPL18A LUC7L UBAP2L CHAC1 EPHA2 EPHB2 RPS11 FGA IER5 EIF2A ACOT9 TMEM170A SND1 INPP4B HEL-S-78p hEMMPRIN KATNAL2 EWSR1 BIN1 TXNIP ALB RPL27 PRKD2 PRKCI RPL26 PPP2CA PFN1 PABPC1 EZR HEL164 ATP6V0D1 MAPKAPK2 CYCS FLII GIGYF2 GSK3B HEL-S-15 DHX36 XB MYO6 MICAL2 PRRC2C LARP7 SRPK1 CALU HYOU1 DHX29 FAF1 KCNC3 CRK CCDC124 ROCK1 SRP54 ROCK2 HBD SHB EEA1 PIK3CA CSRP2 TMSB4X RPLP2 CGNL1 SSR4 SSR3 FJX1 LIMK1 ENG ARHA KANK1 HEL-S-87p CRIP2 SLC7A1 MTOR APOLD1 FGD5 GPC1 FLNB NUMB CDC42 CCT7 BRD4 AAG1 PRKRA TFAM TAOK2 COPG1 FOXO3A GLUD1 FHOD1 ITGB5 CTNND1 PLOD3 RPL10A AMOT CBL EPRS1 tal-1 CCRL2 P4HA2 TMSB10 ITGAV DUSP5 TMOD1 TMOD3 SEMA6D DPM1 FARSB DOK1 DLL4 ARMCX1 RAB37 ADAM9 FRS2 ZNF555 DSC1 LRRC59 HTRA1 FUT1 GRB2 QK3 IGFBP7 ZC3H15 HEL-S-94n SDF2L1 MEF2C HEL-S-84 BMX TPP1 ITGB1 AFDN RCAN1 TFCP2 CNP NR4A3 SPIRE1 GRSF1 MAPKAP1 C15orf39 FHL2 NRARP LDB2 VAV2 RND1 SET CAPZB LRRFIP2 ADAMTS9 SRC SHC1 ARHGEF15 SHROOM2 RPL13A HDAC5 SLC25A11 PPM1G HDAC9 DNAJB4 HDAC7 FAM120A DNAJB9 FYN WASF1 NFATC2 CCL2 SLC25A25 PTPN1 PDE4DIP PTPN11 NFKBIA CDC42BPB FMNL3 PTPN9 PTPN6 CTNNA1 ITGB3 RPS6KA5 GRB10 BMP10 ELOA HEL-S-133P RAB4A PLAUR MAPK9 MAPK8 STAT3 ARF6 CTGF TXN MYO1C HEL-S-99n TUBB8 TUBA1C TRPC3 NRP2 PSMD4 FBXW11 F3 SELE LMAN1 MAPKAPK5 PSMD11 DECR1 SIAH2 EGR1 HEL107 ATP6V1E1 CYP2C8 BIRC5 KL MYH9 ERG TRAF3IP2 FLT1 FOXO1 HEL-S-2a PNP MAPK1 MAPK3 ATF2 HEL2 BCL2 SLC8A1 ACTG1 EIF4G1 CACNA2D1 PRKAA1 GJA1 HDAC1 NCF1 PRKCB PRKCE FXR2 PRKCA HEL-S-102 MYL2 PRKD1 BMP2 ATF4 ELOC MOV10 PRKCZ PLCG1 JUN ARF4 NFKB1 TNFRSF25 NAPA TNFRSF10C SH3BGRL3 CLTC HGS SH2D2A AP2A1 NCF2 IQGAP1 ARRB2 FOXO4 AP2S1 SYNJ1 NCK1 EPN1 ADRB2 PLCB3 CREB1 RICTOR CSK S1PR1 ITCH NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260211%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 AGTR2 REN ACE2 AGTR1 CYP2R1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HEL-S-53e HAT1 HDAC2 HDAC10 DHFR ADH1A HDAC5 HDAC8 ADH1C HDAC9 HDAC7 HDAC6 ATF2 HEL-S-117 ALDH2 SLC19A1 ALDH1A3 MTR HDAC1 ACSS2 TYMS CYP2E1 MAT1A ALDH1A2 HDAC3 KAT2B SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260211%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 TRAF3 IF1AA9 TBK1 IFNAR2 TYK2 IFNAR1 IFNA8 MAVS RIGI IFNA2 ACE2 IKBKE IRF9 IFNA6 IFNA7 TICAM1 IFNB1 JAK1 IFNA1 IFIH1 IRF3 TLR3 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260211%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 NFKB1 MAP1LC3A IFNG IFNB1 MYD88 TNF TRAF6 IRF3 TLR9 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260211%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 CD36 LAMB2 CXCL12 FOXC2 FOXC1 TCF2 VEGFA SHH KDR CTNNB1 PAX2 WT1 SIX1 CD2AP FGF8 NPHS1 NPHS2 NOTCH2 HEL-S-28 LMX1B LHX1 ROBO2 CXCR4 FGFR2 HOXD11 HOXA11 SLIT2 TCF21 GLI3 KIRREL1 ETV4 MAFB NCK2 EMX2 NCK1 FOXD1 EYA1 WNT4 GDNF RET INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP4558%HOMO SAPIENS Interferon mediated signaling IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 IF1AA9 IFNAR2 IFNW1 IFNGR1 PIK3CA IF1IB1 TYK2 IFNAR1 IFNA8 IFNK IFNA2 IFNL2 IFNL3 PIK3R1 IRF9 IFNA6 IFNL4 IL10RB IFNGR2 IFNLR1 IFNA7 IFNE PRKCA IFNB1 IFNG JAK1 IFNA1 IL6 SIGNALING%WIKIPATHWAYS_20260211%WP364%HOMO SAPIENS IL6 signaling GSK3B CREBBP NR2F6 STAT1 STAT3 CRP VAV1 SHC1 TYK2 SOCS3 IL6 NLK MAPK1 MAP2K4 MAPK3 BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2L1 PRDM1 HDAC1 RPS6KB1 MAP3K7 JUNB IRF1 IL6R VIP RAC1 JAK1 GRB2 NCOA1 TIMP1 SOS1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG INS PCSK2 PCSK1 GLP1R NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260211%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260211%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 NKX2-1 FOXG1 TGIF1 NODAL TGIF2 GLI3 FGF8 SHH HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260211%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PLCB4 ITGB1 EGFR PAK1 FLT1 INSR CDH6 FGFR4 CDH2 NRAS DDB1 FOXM1 CDH16 IGF1R KDR PDGFRA CTNNB1 MYC KRAS MET FLT3 CTNNA1 FGFR2 ITGB3 ITGA2B PRKACG EPHA2 NTRK1 ITGA1 CDH9 KIT PAK6 CDH8 PRKAR1B DCAF1 PRKAR1A PAK4 CDH4 ITGA2 CDH10 CDH11 CCND1 CDH12 CDH15 AJUBA ITGA4 CDH17 VGLL4 CD44 ITGB7 CDH19 NF2 CDH24 NGFR WWTR1 PPP1R14A CUL4A LIN28B YAP1 CTGF PPP1CC HEL-S-80p RBX1 CSF1R NTRK2 ITGAM FGFR1 ITGB5 ITGB4 FLT4 ITGAE AMOT ITGB8 ITGAV ITGAX ITGB6 CDH18 LATS1 TEAD4 ITGA7 LATS2 ITGA6 HRAS TEAD2 TEAD3 FGFR3 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G6 ACSL3 FADS1 ELOVL5 PLA2G4B FADS2 ACOX1 ACSL1 ACOX3 ELOVL2 FACL4 PLA2G5 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome TUBA2 STAT3 AMER3 STMN2 MZT2A FAM168B CCDC74A CDC27 CCDC42 ARHGEF4 POTEE GPR148 ARHA RAC1 APC PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 ITGB1 MYH9 LAMB2 HEL113 CDH2 MYO1E SCARB2 SMARCAL1 CD151 PTPRO SYNPO CTNNB1 CLDN1 PAX2 FYN WT1 CD2AP INF2 NPHS1 IRF6 NPHS2 HEL-S-28 LMX1B NOTCH1 CDKN1B HEL114 ITGB3 CD80 WNT1 CR1 PLAUR COL4A3 COL4A5 DAG1 LAMA5 TGFB1 PLCG1 CDKN1C COL4A4 TRPC6 MKI67 CTSL KIRREL3 DKK1 VTN KIRREL2 LRP5 TLN1 PARVA LRP6 FAT1 AGRN LIMS1 PLCE1 ACTN4 PCNA ITGB4 YWHAQ ITGAV NCK1 CDKN1A MME EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways LIF PDGFRA PTPN11 EGF FGFR2 SELENOP STAT3 ARAF ACVR1 SMAD1 ACTR2 ERAS ACVR2B PIK3R2 SMAD6 FZD1 WNT10B WNT10A FZD3 MDM2 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 PTEN JAK1 HRAS FGF23 EGFR SMAD4 FGFR4 PDGFA BRAF BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 AKT3 MAP2K3 MAPK1 MAPK12 MAP2K6 MAP2K1 MAP2K2 WNT5B IL6ST HNF1A RAF1 DVL1 DVL2 FGF8A DVL3 WNT1 WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD MAP2K5 AXIN1 JUN WNT16 MAPK7 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC FGF14 FZD4 SMAD9 FGF13 FGF18 FGF12 FGFR1 FGF2 WNT9B FGF7B FGF7A NOG FOS MAPK6 MAPK4 FGF5C GRB2 SOS1 FGFR3 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CYP11A1 MAPK10 STAR HEL-S-2a CASP3 BAX HSD3B2 PARP2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260211%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CAMK2A FHL2 GUCY1B1 MAPK1 FHL1 MAP2K1 MAP2K2 ADRB1 MYPN TTN RAF1 CSRP3 NUP62 ANKRD2 HEL-S-101 ANKRD23 C22orf13 MDM2 PRKACG TRIM55 TCAP NBR1 ADRB2 TRIM63 PRKCA PRKAR1A ANKRD1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 SOX17 FOXC2 FOXC1 TCF2 BMP4 GATA3 CTNNB1 SPRY1 PAX2 WT1 SOX11 LHX1 ROBO2 HOXD11 HOXA11 HOXC11 SLIT2 IFT27 GLI3 SALL1 IFT25 ROBO1 SIX2 GREM1 ALDH1A2 EYA1 GDNF FAT4 RET BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5031%HOMO SAPIENS Biotin metabolism including IMDs ACACA PCCA PCCB ACACB PC MCCC1 BTD HLCS MCCC2 HUNGER AND SATIETY%WIKIPATHWAYS_20260211%WP5445%HOMO SAPIENS Hunger and satiety GCG LEP POMC GHRL MC4R AgRP NPY PYY ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260211%WP4298%HOMO SAPIENS Acute viral myocarditis TLR4 MMP9 STAT1 SGCA SRC SOCS1 DMD MAPK1 TNF FYN MAPK3 HEL-S-28 BCL2L1 BCL2 EIF4G1 CXCR4 CD80 CASP6 RAC3 IL12B IL12A TICAM1 NFKB2 CD40LG IFNG PABPC1 CCND1 CYCS GSK3B DAG1 CASP9 NOD2 CASP3 TGFB1 HLA-DMA STAT3 BAX IL10 CASP2 DFFB DFFA IL2 IL6 TLR5 CCR5 CASP8 CD55 CCR3 PIK3R1 PARP1 AAG1 PS1TP5BP1 PYCARD CAAP1 SGCD EDN1 CXADR SGCB MYH6 SGCG AIF1 CHRAC1 CREB1 BNIP2 ABL2 MICA JAK1 SOS1 TLR3 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260211%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NLRP3 IKBKE CHUK RELA FCGR2A TBK1 IKBKG NFKB1 IFNB1 IKBKB IL1B REL GSDMD CGAS NLRX1 MITA F3 NFKBIA IRF3 NFKBIE LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G1B PLA2G4E SLCO2A1 PLA2G4C PLA2G3 PLA2G7 PLA2G10 PTGS2 ALOX5 PLA2G5 PLA2G6 CDKN1A HRAS PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYLK EGFR PAK1 ACTR3 DAAM1 MYL1 PFN4 PFN3 PFN2 CAMK1 SRC SHC1 CTNNB1 NEF3 MYC ERBB2 MAP2K4 MAPK1 NEFH ERBB4 NEFL GPX1 HEL-S-44 MAP2K1 TGFA RAF1 CDKN1B DVL1 PPP2CA PFN1 GSK3B MAPK8 AXIN1 FZD10 PLCG1 ROCK2 WNT16 JUN TMSB4X ARHA ACTR2 APC FZD4 FZD1 FZD3 CBL FZD2 FZD5 FZD7 FZD9 NCK1 FZD8 CDKN1A ACTA1 GRB2 SOS1 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260211%WP5360%HOMO SAPIENS KCNQ2 related epilepsies KCNQ2 CALM1 STX1A PPP1R10 KCNQ3 PLCG2 AKAP5 P2RY1 CSNK2A1 SCN1B CHRM1 PRKCA BDKRB2 PPP3CC AGTR1 BACE1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260211%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A ADCY3 ADCY1 ADCY8 CNTF CAMK2G IL10RA BDNF LIF LTA SOCS3 GFAP GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 IL10RB IFNGR2 IL12B IL12A IL6R IFNG SLC1A4 CAMKK1 CAMKK2 TRAF5 TGFB1 STAT3 IL10 IFNGR1 IL13 PPP1CC ARC IL4 HEL-S-80p SLC2A3 SLC1A1 GRIN2B SLC6A9 GLS2 DLAT JAK1 TGFBR2 IL1A PLCB4 SMAD2 PLCB1 SMAD4 PLCB2 INSR STAT1 IGF1 PSAT1 TGFBR1 PSPH NELF GRIN1 SLC38A3 SLC38A5 DAO GRIK5 SLC1A2 GRIK3 IRS1 GRIK1 SLC7A10 MAPK1 TNF GRM2 GRM4 MAPK3 GRM8 PHGDH SRR LRRC8C IL6ST LRRC8D DISC1 LRRC8E BCL2 HEL-S-51e PRKCB PRKCA NFKB2 IL1R1 SLC38A1 GLS HEL-S-15 PIG59 GRIK2 TGFBR3 TNFRSF1A NFKB1 IL6 DLD CALM1 PDHA1 SLC1A3 SHMT1 FGF2 SLC17A6 SLC17A7 FOS IL13RA1 NGF PLCB3 TNFRSF1B CREB1 IL1B IL1R2 CAMK2D CAMK4 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 ADAMTSL2 EGF ZEB2 LTBP1 ZNF423 pp6425 BAMBI FBN1 LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 GDNF SIGNALING%WIKIPATHWAYS_20260211%WP5143%HOMO SAPIENS GDNF signaling WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP399%HOMO SAPIENS Wnt signaling and pluripotency CCND2 CREBBP PPP2R3A EP300 PPP2R2C FOXD3 PPP2R2B POU5F1 WNT7B WNT7A CTNNB1 MYC CTBP2 MAP2K4 SOX2 WNT5B ZBTB33 LDLR PPP2R1B PPP2R1A LRRK2 PPP2R2A LEF1 CCND3 FBXW2 PAFAH1B1 PPM1J PRKCH NKD1 NKD2 PRKCB NFYA MAP3K7 ESRRB NR1C2 PRKCE PPP2R3B DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PPP2CA PRKD1 CCND1 GSK3B WNT2B CD44 MAPK10 PRKCZ MAPK9 AXIN1 FZD10 FRAT1 AXIN2 WNT16 JUN CSNK1E LRP5 NLK LRP6 ARHA APC CTBP1 FZD4 FOSL1 FZD1 WNT10B CTNND1 WNT10A FZD3 FZD2 PPP2R5E WNT9B FZD5 FZD7 FZD9 FZD8 PPP2R5C MMP7 PTPA SLC25A46 PATHWAY%WIKIPATHWAYS_20260211%WP5521%HOMO SAPIENS SLC25A46 pathway EMC7 MICOS13 OPA1 MFN2 APOOL MMGT1 IMMT EMC10 TMEM85 COX4NB MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 MFN1 EMC6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP4595%HOMO SAPIENS Urea cycle and associated pathways SLC25A15 MDH2 ASL GOT2 NAGS SLC25A12 ASS1 GLUD1 ARG1 SLC25A13 LDHB FH OTC GLS2 GPT NOS2 HEL-S-32 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260211%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260211%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis PTGS1 TBXA2R GNA13 ARHGEF1 ARHA 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5407%HOMO SAPIENS 15q11q13 copy number variation STX1A CREBBP NECAB3 APP SPEF1 SMC5 RELA SMC6 LYPD6 ENTREP2 UBN1 MLSN2 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J CXNO CGN CCL5 GOLGA8R GJD3 MTMR10 CANX KLF13 MYZAP OTUD7A TJP3 GOLGA8O CDC42BPB GOLGA8Q TRPM1 FANCD2 STXBP1 GOLGA8H CALM1 FAN1 CHRNA7 ANKRD2 GJA1 HDAC1 CXADR TJP1 SIN3A KAT2B STX1B IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260211%WP2007%HOMO SAPIENS Iron metabolism in placenta TF HAMP IREB2 TFRC HEPHL1 TFR2 SLC40A1 MCOLN1 SLC11A2 HEL60 STEAP3 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260211%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 NR1C2 FFAR3 PYY FFAR2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 SGPL1 PEMT CHPT1 CEPT1 PISD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL OTC NAGS F7 GLS2 ASS1 GPT ARG1 F10 HEL-S-20 IL4 SIGNALING%WIKIPATHWAYS_20260211%WP395%HOMO SAPIENS IL4 signaling PIK3CD IL2RG RELA EP300 CHUK STAT1 STAT3 GAB2 CEBPA CEBPB PIK3CA SHC1 TYK2 NFKB1 IL4 SOCS3 SOCS1 IRS1 MAPK1 FLNA MAPK3 INPP5D BAD ATF2 PTPN11 MAPK11 MAPK14 NFKBIA PIK3R2 PTPN6 PIK3R1 FES SOCS5 CBL RPS6KB1 FOS IKBKB JAK1 STAT5B JAK3 GRB2 SOS1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 CAP1 ELOVL5 IGF2R LPL CYP1B1 CEBPB PICALM SRSF9 TMED10 TMEM43 PHC2 TGFBR2 SRSF10 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling GSK3B ITGB1 SMAD2 WASL MAPKAP1 IGF1 IGF1R TNFRSF1A NFKB1 IRS1 RPTOR MTOR DEPTOR ACVR2B MLST8 HEL-S-28 EIF4E TNLG5A RPS6KB1 IGFBP5 PRKAB1 AKT1S1 MAP1LC3A TRIM63 PTEN EIF2B2 FBXO32 PPARGC1A RICTOR GDF8 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260211%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission NGFR STAT3 ROCK1 PLCG1 BDNF PIK3CA SHC1 NTRK2 GABRG2 ARHA PIK3R2 PIK3R1 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 CREM GABRE GABRQ GABRA2 GABRP SLC12A5 PIK3R3 GABRA6 PTEN GABRA5 GABRA4 GABRA3 CREB1 GABRG3 GABRG1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260211%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PLCB4 POMC PLCB1 PLCB2 ARRB2 GPR143 PRKACG VEGFA PRKCB DCT GNA15 PLCB3 CREB1 ADCY9 PMEL ASIP GNAS TYRP1 TYR MC1R FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism MTTP SLC2A4 APOB NR1C1 ACADM HADHB PPARGC1B STK11 ESRRA ACLY MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260211%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation GSK3B SPRED1 MAP1B MARK1 TAOK1 PHLDB2 MAPRE1 F2RL2 PAK1 STAT3 RHO ROCK1 SRC PARD6A CLASP1 NTRK2 LIMK1 APC CDC42 EPHB2 DVL1 AURKB NTRK1 PRKCA PTEN NTRK3 RAC1 CFL2 WNT3A CDC2 FREP1 TIAM1 MAPKAPK2 TRIO CAMK4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260211%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260211%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 RORC EBP AKR1D1 INSIG1 AKR1C4 CYP46A1 THEM5 DHCR7 HSD3B7 GPR183 ACOT8 LBP ACOT7 NR1H2 ACOT11 ACOT12 BAAT ACOT13 CYP7B1 SULT2B1 CH25H AMACR ACOT6 SLC27A2 ACOT4 CYP3A4 DBP CYP7A1 NR3A2 EPHX2 CYP27A1 NR1i2 CYP8B1 SLC27A5 SULT2A1 IL25 ACOT9 IL17F IL17D IL17C IL17B IL17A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260211%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP2 SGPP1 SPTLC1 SPTLC2 KDSR SPHK2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260211%WP727%HOMO SAPIENS Monoamine transport and regulation STX1A TDO2 TSC2 TPH2 ACHE TGFB1I1 TNF HRH3 NECTIN2 MAPK14 ADORA2A SLC5A7 ITGB3 SLC6A3 TNFRSF11B TH RBL2 UNC13B IL1R1 FBXO32 AMPH IL1B SLC6A1 SLC6A2 SYN1 DBH ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260211%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC KDR SLIT2 RAC1 ROBO4 VEGFA PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP136%HOMO SAPIENS Phase I biotransformations non P450 CES2 CES1 PON3 PON2 ESD PON1 LIPA HEL126 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260211%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL1 LOXL2 LOX SMAD2 SMAD4 MAPK9 BMP1 MAPK8 TGFB1 GREM1 TGFBR1 BMPR1A BMPR2 MAPK14 TGFBR2 LOXL4 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL GOT2 GAD2 AGXT ASPA ASS1 GAD1 GPT PC ABAT MEVALONATE PATHWAY%WIKIPATHWAYS_20260211%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 PMVK MVD ACAT2 HMGCR FDPS SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260211%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 DLL3 MESP2 LFNG HES7 EPHA4 RIPPLY2 TBX6 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 DHCR7 LBR HMGCR NR1H2 CH25H FDFT1 SQLE SOAT1 FADS2 SCD CYP27A1 FADS1 MYLIP ELOVL5 FASN ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK SREBF2 HMGCS1 SOAT2 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 FACL4 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members PARP14 PARP11 PARP1 HDAC2 RBX1 STAT1 STAT3 HDAC3 DTX3L BTRC SKP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP47%HOMO SAPIENS Hedgehog signaling SMO SUFU DHH PTCH2 SAP18 KIF7 SIN3A PTCH1 IHH GLI3 ADRBK1 SHH ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction NFKB1 IFNAR1 TNF ACE2 IFNA1 TNFRSF1A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260211%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS5 PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260211%WP710%HOMO SAPIENS DNA damage response only ATM dependent CDKN2A CCND2 SMAD4 BAK1 INSR NRAS MAP3K1 WNT7B WNT7A SHC1 CTNNB1 HMGB1 MYC AKT3 IRS1 ERBB2 MAPK1 SOS2 KRAS WNT5B BCL2L11 BCL2 LDLR CDKN1B BBC3 LEF1 TNFSF6 CCND3 RAC3 MAP3K7 RBL2 DVL1 PIK3R3 DVL2 TCF7L2 DVL3 TCF7L1 NFKB2 PMAIP1 WNT1 WNT3 MLKL WNT4 G6PC1 PCK2 WNT3A CCNG2 CCND1 GSK3B WNT2B PIK3CD MAPK10 MAPK9 MAPK8 TGFB1 TP73 BCL6 BAX AXIN1 FRAT1 WNT16 JUN PIK3CA NFKB1 ARHA BAD BIK PIK3R4 APC PIK3R2 PIK3R1 CDC42 PIK3R5 FOSL1 PIK3C2G FOXO3A WNT10B PIK3C2A WNT10A MDM2 PIK3C2B ATM PPP2R5E CDKN1A PTEN PPP2R5C RAC1 HRAS GRB2 SOS1 BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5055%HOMO SAPIENS Burn wound healing TLR4 MMP9 FST KLF4 TNC INHBA FGFR4 VEGFA SNAI2 HMGB1 HGF ACHE TNF CCL2 COL1A2 BCL2 EGF CHRNA7 CXCR4 FGFR2 FBN1 F13A1 PECAM1 FOXE1 HEXD DKFZp686P11128 DCN TIMP1 KRT6A KRT222 FLG IL15 PCTK1 SCEL HEL-S-43 COL1A1 AMBP SLURP1 MYD88 CASP3 LIN28A CD3E CXCL12 TPT1 BAX NFKB1 IL6 CXCL8 S100A6 IFNA2 BRD4 FGFR1 S100A9 NOX4 MMP28 ACTA1 IL8RB IFNB1 MMP2 IL1B CXCL1 FGFR3 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260211%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p C7orf24 OPLAH GCLC HINT1 PATHWAY%WIKIPATHWAYS_20260211%WP5523%HOMO SAPIENS HINT1 pathway MAPK9 CDK7 RUVBL1 GTF2H2C_2 KARS1 CCNH GTF2H2 JUN GTF2H3 GTF2H5 SH3RF1 FOS NFKB1 HINT1 ERCC2 TCF4 RUVBL2 CTNNB1 MNAT1 NFATC2 USF2 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260211%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 AKR1C4 AKR1C2 CYP3A4 CYP1B1 CYP1A1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260211%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DICER1 DROSHA ERI1 AGO2 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260211%WP4537%HOMO SAPIENS Hippo YAP signaling NF2 MAP4K1 MAP4K2 WWTR1 MINK1 YAP1 MAP4K3 RASSF1 LATS1 TEAD4 LATS2 STK38L TNIK TEAD2 TEAD3 HEL-S-31 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 MAPK8 TNFSF11 ITGB3 TRPV5 TNFRSF11B CTSK TNFRSF11A IFNAR1 IFNB1 SPP1 GPR68 AIMP2 ACP5 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB1 CACNB1 CDH2 SGCA CTNNB1 DMD CACNG1 CTNNA1 SLC8A1 CTNNA3 CTNNA2 ACTG1 tmp_locus_29 CACNA2D1 ITGB3 GJA1 LEF1 CACNA1C ITGA2B CACNA1F LMNA EMD TCF7L2 TCF7L1 ITGA1 CACNB3 CACNA1S ITGA2 ITGA4 DAG1 ITGB7 PKP2 JUP ACTN2 ACTN1 ACTN4 CACNA2D3 CACNA2D2 CACNA2D4 RYR2 CACNB4 ATP2A2 DSG2 DSC2 CACNG6 CACNG7 ITGB5 CACNG8 ITGB4 CACNG2 CACNG3 PS1TP5BP1 CACNG4 CACNG5 ITGB8 ITGAV ITGB6 SGCD SGCB SGCG ITGA7 ITGA6 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260211%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GSK3B PIK3CD TSC2 TSC1 NRAS UBE3A BDNF GRIN1 PIK3CA ARC NTRK2 DLG4 AKT3 PRKAA2 EIF4EBP1 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R2 PRKAG1 PIK3R1 PRKAG2 PRKAG3 PRKAA1 GRIN3B GRIN3A NF1 CACNA1C PRKAB2 SHANK3 RPS6KB1 RHEB PRKAB1 GRIN2B PIK3R3 SYNGAP1 PTEN HRAS HOMER1 CAMK4 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MEF2C ARAF NRAS BRAF GAB2 CRK MAP3K2 VAV1 SRC PIK3CA SHC1 AKT3 MAPK1 KRAS CRKL MAPK3 SHC4 INPP5D ATF2 SHC2 MAPK11 SHC3 MAPK14 BCR PIK3R1 BCL2 EIF4B HSPB2-C11orf52 BCLAF1 BCL9 RAF1 CBL RPS6KA1 SPAG1 PXN DOK1 HEL-S-102 HRAS GRB2 SOS1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260211%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 ANGPT2 PRKD3 PPP3R2 PRKCZ RCAN1 PRKCH PKN3 PKN2 PRKCB PKN1 NFATC1 PRKCE PRKCA PLCB3 PPP3CA PPP3CC PRKD2 PRKCI PRKCQ PRKD1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260211%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling IFITM3 CEBPB CCL8 RPTOR CCL4 LARP1 CCL1 DEPTOR MLST8 VPS11 EIF4E VPS16 CCL15 VPS18 GABARAPL2 VPS33A RPS6 RHEB AKT1S1 VPS41 HIF1A AHR LCK IF2B1 TF CD3G IL-21 CD3E CXCL12 IL18RAP PIAS1 IL10 IL13 IL4 IL5 RRAS CXCL8 APOC1 SMAD1 ULK1 SIGMAR1 IL9 HEL117 MMP25 IFIT1 GTSE1 VPS36 WDR74 CD226 TRPM2 APOH APOD RAC1 HEL103 JAK1 INTS4 HRG CXCL13 CTSZ TGFBR2 SERPINA10 SDF2 CCR6 IL1A TOMM70 GP1BA IL16 HMFT1766 IFI6 OS9 PTGS2 MIB1 STAT1 SRP19 HEL-S-81p HP IFI44L CLCC1 TLE3 GTF2F2 UGCGL2 G3BP2 CXCL6 NLRP1 DKFZp781O1323 NPTX1 MDN1 IFITM1 FAM83A CXCL3 NEK9 IL7 CD163 TP53I3 LGALS3BP TNF TRO TRIM59 BST2 ITIH3 ATE1 IFI27 MX1 CCL20 TBKBP1 ATP13A3 IL33 FAM98A CCL22 CCL21 HBB CCL27 PF4 CCL26 DDIT4 RTN4 FGA HEL-S-78p NFKB2 ALB SAA1 SAA2 IRAK1 CASP9 MYD88 CASP3 TRAF2 TRAF6 SRP54 HBD CXCL5 MTOR TPO FGF2 PMPCB IFNB1 ADAM9 IL1R2 CXCL9 PITRM1 CXCL1 CCL3 NLRP3 HEL-S-130P CXCL2 CRP RRM2 GGH CCL11 ZAP70 CARD11 CCL5 EIF4EBP1 HLA-DRA NFATC3 FYN CCL2 APOA2 PTPN6 OAS2 IRF9 C8A IL12A C1QBP CCNB2 IFNG CCNB1 CDC2 IL17A HLA-DRB5 NRF CD8B1 MAPK8 PRG3 CD2 CFH IGLL1 CD8A CFI LBP CFP CTSL CPN1 CASP8 PARP2 C1R SELP HEL-S-72p EGR1 IFIH1 IRF3 CD14 BIRC5 ITIH4 TRAF3 HLA-DRB1 APOL1 ACE2 CASP5 COQ8B ACTG1 TNFSF10 STEAP3 JUNB NTRK1 PRKCQ MOV10 DKFZp762B153 TBK1 IKBKG JUN IL6 CCR5 MAVS RIGI EIF4A2 PS1TP5BP1 CXCL16 FOS IL8RB IL18 IL1B CXCR1 ITCH CAMK4 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260211%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling GSK3B RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 CEBPD CTNNB1 SPP1 APC CSNK1A1L TOR1AIP1 SLC2A4 CDK6 PPARG WNT10B LEF1 ZMPSTE24 FNTA LMNA HES1 EMD HES5 TCF7L2 TCF7L1 ICMT HMGA2 DICER1 TARBP2 CCND1 AGO2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260211%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 SMARCC1 SMARCA4 MBD5 NCOA6 SMARCD2 ARID1A PAXIP1 SMARCC2 SMARCD3 KMT2C ACTL6B DPY30 ARID1B PAGR1 ASXL1 WDR5 BAP1 ACTL6A EHMT1 ASH2L H3F3B RXRA NR1I3 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260211%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways OSTM1 PLEKHM1 NFKB1 SNX10 TNFSF11 IKBKB TCIRG1 TRAF6 RAB7A TNFRSF11A CLCN7 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260211%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KNG1 CYP24A1 AGTR2 REN KLKB1 ROCK1 NFKB1 CPN1 KLNA1 BDKRB2 CYP3A4 PRKG1 IL1B MAPK1 NR1i1 TNF ARHA BDKRB1 ACE2 AGTR1 IL1A SERPING1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260211%WP5234%HOMO SAPIENS Bardet Biedl syndrome USP9X PDE6D BBIP1 DYNC2I2 INVS NPHP3 DYNC2H1 CRX DYNLT2B TRAF3IP1 SUFU CEP164 FLCN DYNC2LI1 IFT52 KIF7 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 OCRL CEP290 SCAPER ZIC2 BBS4 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 MAK IFT172 TMEM216 EFHC1 WDPCP EFHC2 IFT74 CNGB1 SDCCAG8 PKD1 CEP104 ARL6 ARL3 PKD1L1 PKHD1 PTCH1 ARL13B TMEM67 INPP5E EVC2 BBS2 NEK8 BBS1 PCARE SMO SCLT1 DCDC2 IFT81 FUZ TTC8 GPR161 MKS1 CEP41 IFT27 TRIM32 GLI3 CLUAP1 RAB23 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260211%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1A2 NAA50 CYP2J2 GATF-C CYP21A2 GLYATL2 AKR1D1 CYP4F11 AKR1C4 CYP46A1 CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 NAT9 NAA40 NAT10 NAT14 LOC51064 CYP7B1 SULT2B1 HS2ST1 SULT1C3 CYP26B1 CYP4V2 HYAL3 CYP2C19 UGT2A2 CYP3A7 UGT2A1 CYP3A4 GAL3ST2 CYP2W1 GAL3ST3 SULT1C4 CHST8 HS3ST3B1 CHST9 EPHX2 CHST6 CHST7 CYP2R1 CYP3A43 KCNAB1 KCNAB3 CYP2A7 CYP26C1 CHST1 CHST4 CHST5 CHST3 HEL-S-75p NAA20 UGT2B28 CYP17A1 CYP2A13 UGT1A5 AKR1B1 CYP2F1 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 GSTZ1 CYP20A1 CYP4F2 CYP4F12 HEL-S-165mP EPHX1 CYP7A1 CYP11A1 MGST1 GSTT2 UGT1A3 SULT2A1 CYP1A2 CYP1B1 MGST3 GPX3 MGST2 CYP1A1 CYP2E1 GSTM3 NNMT TPMT INMT GSTM5 CYP4F8 CYP2C8 UGT2B4 UGT2B7 NAT2 CYP2S1 GSTM1 SULT1A1 SULT1E1 BAAT CYP27B1 SULT1C2 CYP11B2 HEL-75 CYP27A1 GSTM2 CYP8B1 GSTA5 CYP2C9 GSTA4 CYP2A6 GSTA3 UGT1A10 CYP2B6 UGT1A1 UGT1A9 HEL-S-64p HS3ST2 GSTM4 GPX4 CYP51A1 CYP24A1 GPX2 HEL-S-22 UGT1A4 UGT1A7 AKR1C1 AKR1C2 HEL-S-75 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 HEL-S-21 HEL-S-166mP UGT2B11 GAL3ST4 UGT2B15 UGT2B17 CYP2U1 SULT6B1 HS3ST3A1 CYP4F22 CYP4X1 CHST11 CHST12 CHST10 CYP2C18 CHST13 CHST14 NAT8L GSTT2B SULT1A4 CYP4F3 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling CDKN2A EGFR MAPK8 BAK1 BAX TRAF2 TRAF6 JUN TNFRSF1A FAS PDGFRA IL2 IL6 MAP2K3 HBEGF MAP2K4 TNF MAPK12 BMF MAP2K6 MAPK13 MAP3K5 ATF2 FGF7 MAPK11 MAPK14 BCL2L11 BCL2L1 BCL2 NFE2L2 TNFSF10 TNFSF6 CCNE1 JUNB FOS CCNA2 CDKN1A IFNG RB1 MMP2 MCL1 CCND1 TRAF5 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260211%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BCL2 ATG3 TSC2 INSR TSC1 ATG12 ATG16L1 INS ATG14 MAP1LC3A ATG5 AMBRA1 SH3GLB1 CHAF1A UVRAG ATG9B ATG10 ULK2 VMP1 ULK1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260211%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 GCK ACSS1 MTTP LMF1 LDLR PLTP GPIHBP1 LPL FAS PDIA2 APOA5 APOC2 LIPC GCKR DGAT2 APOA2 SEL1L COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome CDCA5 NIPBL SGOL1 PTTG1 ESCO1 ESCO2 REC8 SMC1B MAU2 STAG2 SMC3 STAG3 ESPL1 WAPAL HDAC8 APC PLK1 PDS5B PDS5A PPP2R1B RAD21 PPP2R1A PPP2R5E SMC1A PPP2R5B PPP2R5A AURKB PPP2R5D PPP2R5C PTPA PPP2CA CDC2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5380%HOMO SAPIENS 5q35 copy number variation PDLIM7 SLC34A1 FGFR4 PFN3 IGF1R CAPN3 SRC GRIN1 MYC KDM6B HEL-S-273 COX2 GPRIN1 ARL10 H2AX CXCR4 ADAM10 PTH FGF8A TMED10 HK3 NTN1 COX1 MAPK10 MAPK9 MAPK8 GNAI1 RNP24 PLCG1 PRR7 EIF4E1B GNAI3 JUN COX7B KIAA1191 COX4I1 FAF2 MAX CLTB DDX41 TRIAP1 COX6A1 BABAM1 BABAM2 BARD1 UIMC1 COX8A EED INPP5D TMED9 RNF44 CYP7A1 UNC5A MYO7B PNPLA2 COX6B1 PIK3R1 ARFGAP2 FBXW7 HIC2 DOK3 CDHR2 FAM193B DBN1 ABRAXAS1 USH1C BRCC3 COX7A1 LMAN2 MAGED1 RAB24 COX7C COX3 ZNF346 SNCB PRELID1 PTPRN2 NELFB NOP16 GRIN2B MUPCDH COX5A HIGD2A TSPAN17 BRCA1 DRD2 SNCA ANKS4B H3F3B MXD3 FRS2 ABHD5 GRB2 SOS1 RGS14 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5275%HOMO SAPIENS Ether lipid biosynthesis DHRS7B AGMO AGPS LPIN1 LPIN2 LPIN3 CEPT1 FAR1 UGT8 PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L PEX3 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation MIXL1 ITGB1 KLF4 CNP HOMER3 MBP FOXD3 MSX2 PAX3 MOG S100B OLIG2 SOX10 GFAP ACHE TWIST1 GATA4 NEFL MSX1 LHX1 GAD2 NR2A1 TPM1 GAD1 GATA6 MAP2 TWIST2 DLG4 CLDN11 ERAS CASK CACNG2 ROBO1 SHANK3 GRIN2B SLC6A5 SLC6A9 DLG2 SHANK1 SLC6A1 SLC6A2 HOMER1 TNC AQP4 RIMS2 BSN CDH2 RBFOX3 FBXO15 TBR1 SNAI1 ZFP42 SNAI2 LIN7A BMP4 FUT4 POU5F1 TPH1 ChAT HOMER2 GRIN1 FEV CD24 NEF3 PCLO ERC1 SLC1A2 CD34 PAX6 ADRA2C ADRA2B ADRA2A DPPA3 DPPA2 SOX2 DCX TBXT GLRA1 GLRA2 LMX1B GLRA3 NOTCH1 GABBR1 HTR5A GLRB RIMBP2 NLGN1 5HT1A CSPG4 FOXA2 SLC6A3 LEF1 HES1 ESRRB HES5 PECAM1 GLS NGFR SOX17 PIG59 GPHN GABBR2 KCNJ6 SNAP25 SOX9 SLC1A3 NODAL AP2A1 AP2A2 TH SLC17A6 SLC17A7 FGF7A SLC18A3 HES3 UNC13A ITGA6 SYP CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 ADCY1 MAPK9 MAPK8 DAGLA CYP2C19 CYP3A4 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 ADORA2A FAAH CYP2C9 CNR2 NAPEPLD DAGLB PRKACG CYP1A1 PRKAR1B CNR1 PRKAR1A AHR TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R5 PIK3CD EGFR RAF1 PIK3C2G PIK3C2A PIK3C2B NRAS PIK3CA PIK3R3 AKT3 ERBB2 MAPK1 ERBB4 KRAS MAPK3 HRAS PIK3R4 PIK3R2 PIK3R1 ERBB3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260211%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IF2B1 IL15 RORC RORA ID2 TBX21 IL13 GATA3 TOX IL4 IL6 IL5 IL7 TNF IL33 ZBTB16 HNF1A TSLP IL9 IL25 GFI1 ATL1 NFIL3 IL12B IL12A IL18 IFNG IL23A IL1B AHR IL17A AREG MAPK SIGNALING%WIKIPATHWAYS_20260211%WP382%HOMO SAPIENS MAPK signaling TAOK1 CACNB1 LAMTOR3 RRAS2 CACNG1 SOS2 EGF FGFR2 PRKACG PLA2G4B ARAF CDC25B NFATC1 MAX RASGRP3 RAP1A RRAS DDIT3 CRKL GADD45A CACNA2D3 CACNA2D2 PPP3R1 CACNA2D4 PPP3R2 CACNB4 CACNG6 CACNG7 CACNG8 NF1 CACNG2 CACNG3 CACNG4 CACNG5 MAP3K13 IKBKB PPP3CA RAC1 PPP3CC HRAS TGFBR2 IL1A EGFR NTF4 PAK1 RELA FGFR4 NRAS MAP3K1 MAP3K7IP1 FAS FGF10 RPS6KA3 MAP2K3 MAP2K4 TNF MAPK12 MAP2K6 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K11 SMIM40 RAF1 TNFSF6 CACNA1C CACNA1F FGF8A NFKB2 IL1R1 CACNA1S FGF6B MAPKAPK2 MAP2K5 CASP3 CHUK TRAF2 TRAF6 CRK TNFRSF1A MAPK7 NTRK2 NLK FGF20 FGF22 FGF7 FGF21 FGF8 DUSP4 FGF9 FGF16 FGF14 FLNB CDC42 FGF13 TAOK2 FGF18 FGF12 FGFR1 FGF2 FGF7B FGF7A DUSP2 NGF FGF5C IL1R2 GRB2 SOS1 FGFR3 MEF2C BDNF FLNA NFATC3 STK4 RPS6KA4 RPS6KA5 RAC3 MAP3K8 MAP3K6 MAP3K7 MAP3K12 HEL-S-31 MAPK10 MAP4K1 MAPK9 MAP4K2 MAPK8 TGFB1 MAP4K3 MAP3K2 HEL-S-103 HEL-S-72p RASGRF1 MAPKAPK5 HSPA2 PLA2G4F CD14 FGF23 PLA2G4D PLA2G4E PLA2G4C PDGFA BRAF TGFBR1 MYC AKT3 JUND MAPK1 DUSP10 KRAS MAPK3 ATF2 CACNA2D1 LRRK2 MAPK8IP3 MAPK8IP1 ECSIT DUSP3 DUSP8 DUSP9 DUSP7 PRKCA RAPGEF2 NTRK1 NTF3 TAOK3 CACNB3 RASGRP4 CACNA1H CACNA1G CACNA1I HEL-S-102 RASGRF2 DUSP16 PPM1B RASA2 pk ATF4 PPP5C MAPK8IP2 RELB IKBKG JUN GNG12 MAPKAPK3 NFKB1 MAP3K14 CACNA1B CACNA1A ARRB2 FOS IL1B PTPN5 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP4159%HOMO SAPIENS GABA receptor signaling GPHN GABBR2 GABRG2 SLC6A11 GABBR1 GAD2 AP2A1 GAD1 AP2A2 GABRB3 GABRB2 ABAT AP2S1 GABRB1 GABRE GABRQ GABRA2 GABRP AP2M1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 SLC6A1 GABRG1 SLC32A1 ALDH9A1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260211%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HEL25 CBX3 MBD2 CBX1 CHD4 HDAC2 CHD3 MTA2 H3C8 RBBP7 MTA3 MBD3 HDAC1 LEF1 SUV39H1 KDM1A H3C15 RB1 H3F3B RBBP4 KALLMANN SYNDROME%WIKIPATHWAYS_20260211%WP5074%HOMO SAPIENS Kallmann syndrome TMEM98 GNRH1 NEUROG1 FGFR1 SEMA3E ASCL1 OTX2 ANOS1 PIK3CA PLXND1 OLIG2 PROK2 SOX10 MYRF FRS2 MAPK1 LHB PTPN11 FGF8 GRB2 MAP2K2 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260211%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma DKFZp762B153 NFE2L2 STAT3 TFEB MDM2 IPO8 PINK1 AGER PARK2 NFKB1 HMGB1 SQSTM1 KRAS VMP1 SHOC2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence CYP2C8 FADS1 ELOVL5 ALOX12 LTC4S PTGS2 CYP2C9 HEL-S-22 ALOX5 ALOX15B CYP1A2 ALOX15 HPGD GPR32 FPR2 CYP2E1 PTGS1 PTGIS CYP3A4 GSTM4 FADS2 EPHX2 ELOVL2 PTGES SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260211%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 RPS6KA5 BRAF HTR4 HTR6 HTR7 RAP1A CREB1 MAPK1 EGR1 MAPK3 ATF1 GNAS MAP2K1 MAP2K2 MAPKAPK2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260211%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome AFDN F11R GJA3 GJA5 ACP6 CTNNB1 GJA8 AMELX NBPF12 CHD1L PRKAA2 PYGO2 TJP3 PRKAG1 PRKAG2 PYGO1 BCL9 PRKAG3 PRKAA1 GJA1 KIRREL1 PRKAB2 PRKAB1 FMO5 TJP1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260211%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex HIST1H2BE HAT1 ASF1A CREBBP ASF1B HDAC2 EP300 MBD3 EP400 MAPK3 H2BC21 H2AX HDAC1 TLK2 RBBP4 KAT2B MBD2 CHD4 CHD3 MTA2 H3C8 H3C15 PWWP2B UBTF PWWP2A TBP SIRT7 POLR1A POLR1C POLR1D RRN3 SRCAP TAF1D H2AC19 TAF1B H2AB1 TAF12 H2AC14 GATAD2B H2BC26 GATAD2A H2BC12L CDK2AP1 HIST1H2AB H2BC9 KAT2A H2AZ1 H2AZ2 H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 H2BC1 H2BC17 H3F3B H2BC12 H2BC13 H2AJ H2BC14 H2BC15 H2AC20 H2BC11 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PLA2G1B PTDSS2 PTDSS1 CHKB PCYT2 ETNK1 GPAM PEMT CDS1 CHPT1 CRLS1 PISD AGPAT4 GPAT4 PNPLA3 DGKZ DGAT1 DGAT2 CDIPT PNPLA2 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP699%HOMO SAPIENS Aflatoxin B1 metabolism HEL-S-166mP EPHX1 CYP3A4 CYP1A2 GSTM1 CYP2A13 CELL CYCLE%WIKIPATHWAYS_20260211%WP179%HOMO SAPIENS Cell cycle MCM5 MCM6 TTK CDKN2A CCND2 FZR1 HDAC2 CDC45 WEE2 EP300 CDKN1B CCND3 E2F2 ANAPC1 SMC1A CCNA2 CCNE2 CCNB3 CCNB2 RB1 CCNB1 GADD45B CDC2 GADD45G CCND1 CHEK2 CHEK1 PTTG1 TGFB1 SMC1B CDC25B STAG2 CCNH SMC3 CDC27 ESPL1 E2F4 GADD45A PLK1 TFDP2 MCM2 RAD21 CDK7 MAD2L2 STAG1 MDM2 CCNE1 ATM ATR CDC20 SMAD2 SMAD4 WEE1 CDK4 MYC CDK2 HEL2 HDAC1 RBL2 RBL1 TFDP1 CDKN2D CDKN2B E2F5 CDKN2C GSK3B SFN CDKN1C SKP1 RBX1 PRKDC PCNA CDK6 E2F3 YWHAQ HEL-S-1 CDC14B YWHAG CDC23 PTTG2 SKP2 ANAPC7 ANAPC5 YWHAZ MAD1L1 ANAPC2 CDKN1A ANAPC13 PKMYT1 ANAPC11 ORC6 ORC3 ORC2 CDC6 MCM7 ORC1L DBF4 MCM3 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL23 HEL-S-310 RPS6KA2 RPL4 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPS15 FAU RPS14 RPL13A RPL7A RPS6KA3 RPS17 RPS16 RPS18 RPL36 RPL35 RPL38 RPL37 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPS6KB2 RPL5 RPL22 RPS3A RPL30 RPL7 RPSA RPS6KA6 RPL18A RPS6 RPL37A RPL29 RPL28 RPL10 RPL12 RPS11 MRPL19 RPS6KB1 RPL36A RPS4Y1 RPS15A RPL14 RPS19 RPS3 RPS27A RPL13 RPS2 RPL11 RPL15 RPL18 RPL17 RPL19 RPL27 RPL41 RPL35A RPL26 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP2 RPL10A RPS6KA1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2858%HOMO SAPIENS Ectoderm differentiation HDAC10 FHL2 LDB2 PAX3 SOCS2 DMD HDAC6 FYN CCL2 CDON PRKAG2 ZBTB16 LHX1 CTNNA2 FGFR2 MAFB POU2F2 ELOVL4 GATA6 NR1C2 TCF3 NUMA1 CDH8 SDCBP GAS2L1 KRT6A RGMA NF2 CTNND2 ARHGDIG KCNK10 TLE5 ROR2 MZF1 ASTN1 LY6E ARX STC1 NFATC1 ARHGAP15 ZBTB2 JUP PLXNA2 RHPN1 ST8SIA4 HESX1 ZBTB7B TFAP2C SMURF1 GREB1 NR2F2 CLDN11 PAN2 PTPRB PPFIBP2 SCHIP1 HMGB2 WDR44 SIX6 AHI-1 BOC RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 FZD5 ARHGEF9 BMPR1A KIFC3 RUTBC3 STX16 FZD8 RRBP1 TBL1X CLVS1 TTC14 TNLG7C SNCA C1GALT1 TRPM2 VAX2 RIT1 GLB1 ZNF219 BCOR SKIL MYORG ELOVL2 SMAD4 CDH6 OGT BMP4 SHH CTNNB1 MYC PAX6 TFAP2A SOX2 CAP2 PDE7A NLGN1 FOXA2 TNFRSF11B TCF7L1 WNT1 SPRY2 CELSR2 NLK UBTF ZFHX4 PTPN13 PIM1 CTBP1 FZD4 MKS1 GLI3 H2BC9 TOX3 CAMKK2 PATHWAY%WIKIPATHWAYS_20260211%WP4874%HOMO SAPIENS CAMKK2 pathway GALNT9 MAMDC2 ATP1B2 MID1 ERAF CRTC2 SPINT1 PAK1 C1QTNF12 EPOR EP300 FAM20C RELA SPIRE1 ARHGEF7 SFI1 IFI44L ATP10D TSPAN33 RHD CAMK1 ENHO CYB5R3 TSPAN8 SLC25A21 NLRP1 KDR FIS1 STIM1 SLC38A5 WFS1 KLF1 LR8 SLCO3A1 CCL5 TRPV4 CPOX MAPK1 RHAG TNF MAPK3 NFATC2 HFE RPTOR TBXT SLC2A4 ACACA RAF1 FASN NFE2L2 RPS6 SIRT1 ABCA1 RPS6KB1 SMC1A MAP1LC3A SQSTM1 HIF1A CAMKK2 PCK2 CCND1 MX2 KEAP1 VCAM1 GCK IL15 HMBS DKFZp762B153 CHRM3 TSC1 WDR35 DGIC HMOX1 PFKFB2 HK2 ULK1 MTOR CALM1 SELL PARP1 ASNS CCNE1 S100A8 AQP1 CREB1 RAC1 MAF MS4A3 CXCL11 IFGGE OASL ERMAP CAMK4 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260211%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CHRNB4 CACNA1C RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260211%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA EGFR PTEN RPL11 AKT3 FOXO3A MAPKAP1 RICTOR RIOK2 RIOK1 MTOR MLST8 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260211%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 MAVS RIGI IFIH1 MR1 IRF3 TLR8 TLR7 TNFRSF11A TLR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260211%WP3958%HOMO SAPIENS GPR40 role in insulin secretion GNA11 PLCH1 PLCD3 PLCB1 PLCB2 PLCB3 PKD1 PLCG2 PLCG1 PLCL1 PLCE1 FFAR1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260211%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX3 ARID5B TBX1 UCP1 PRDM16 PPARGC1A IRX5 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260211%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260211%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC RBX1 CBFB CUL5 UBB RUNX1 APOBEC3G NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B3GNT5 NEU2 FUT5 B4GALT1 FUCA1 FUT1 NAGA FUT2 SIAT4C B4GALT4 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260211%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NFE2L2 TGFB1 NQO1 SIRT1 CDC37 EXOC6 ECSIT DDR1 SUV39H1 NRF1 HEL-S-7 PKD1 COL2A1 FGF7 BMP2 IGFBP7 LOXL4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC1A RAD21 RAD18 PAXIP1 BRCA1 MRE11A MDC1 ATM SMC3 NBN RAD50 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260211%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELE TLR4 SELP TGFB1 SELPLG PF4 CD40 CD40LG CCL5 IL1B CCL2 TLR7 VCAM1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5304%HOMO SAPIENS Cholesterol metabolism CD36 STAR PBR LIPC LIPA APOA2 CYP27A1 PCSK9 APOA4 SCARB1 MTTP APOB LDLR MYLIP PLTP ACAT2 LPL HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK LIPG MVD NPC1 ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MGAT1 CIDEB FABP2 VAPA EBP CYP51A1 SC5D DHCR24 DHCR7 LBR LPA HMGCR FDFT1 DGAT1 SORT1 SQLE APOC2 SOAT1 APOC3 ABCG8 APOC1 ABCG5 CYP7A1 APOE ABCB11 APOH STARD3 NPC1L1 NPC2 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260211%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 DROSHA MRE11A ATM NBN RAD50 DDX1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260211%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 NFE2L2 SLC3A2 SLC7A5 KEAP1 ATF4 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP4249%HOMO SAPIENS Hedgehog signaling HHIP SPOP CSNK1G3 CCND2 SMURF2 FBXL17 SPOPL CSNK1D GAS1 CSNK1G2 CSNK1G1 EVC ADRBK1 CSNK1A1 SHH CSNK1E DHH IHH SMURF1 PTCH1 CDON EVC2 CSNK1A1L BCL2 SMO BOC ARRB2 GPR161 GLI3 PRKACG SUFU PTCH2 KIF3A KIF7 CCND1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260211%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ELOVL5 ACE2 FADS2 ELOVL2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS SLC7A11 PHGDH PSAT1 PSPH ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260211%WP2374%HOMO SAPIENS Oncostatin M signaling RELA STAT1 CEBPB VEGFA SRC TYK2 SHC1 SOCS3 IRS1 CDK2 MAPK1 JUND KRAS MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 IL6ST RAF1 CDKN1B RPS6 PRKCH PRKCB PXN JUNB PRKCE PRKCA OSMR HIF1A STAT5B PTK2B JAK3 OSM MAPK9 MAPK8 CASP3 STAT3 NFKB1 MTOR PIK3R1 FOS CREB1 JAK1 RICTOR EGR1 HRAS GRB2 SOS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260211%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness CREB1 MAPK1 RYR3 ITGB3 MFAP5 MAPK3 TNNC1 PRKCQ PLCG1 JUN ITGAV GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis NOTCH1 MESP2 LFNG HES7 EPHA4 RIPPLY2 WNT3A FGF8 TBX6 HES1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260211%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC1H1 DCTN1 ADCY3 RAB11B DYNC1LI2 DNCL1 ADCY6 AQP4 ARHGDIG DCTN6 DCTN5 DYNC1I1 RAB5B DCTN4 HEL-S-47e HEL-S-77 AQP2 AQP3 ARHGDIB AVPR2 DYNC1LI1 RAB11A GNAS RAB5A DYNC2H1 CREB3L3 AVP CREB3L4 PRKACG DYNLL2 CREB3L2 CREB3 RAB5C DYNC2LI1 CREB1 ADCY9 STX4A CREB5 VAMP2 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP712%HOMO SAPIENS Estrogen signaling BCL2 MAPK9 CHUK GNGT1 BRAF IKBKG JUN PIK3CA FOS NFKB1 SP1 GPER IKBKB CREB1 MAPK1 GNB1 GNAS MAP2K1 MAPK14 CORI CYCLE%WIKIPATHWAYS_20260211%WP1946%HOMO SAPIENS Cori cycle INS SLC2A4 HEL-S-68p PGAM1 HEL-S-133P PFKP GPT HEL-S-49 HEL-S-87p HEL-S-162eP SLC2A2 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK1 TLR4 IRAK4 MYD88 TRAF6 AGER NFKB1 TREM1 IL6 IFNB1 CXCL8 IL1B MAPK1 TNF HEL110 IFNA1 CD14 IL1A TGFB SMAD SIGNALING%WIKIPATHWAYS_20260211%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2 SMAD4 WWTR1 SPARC TGFBR3 POSTN CTGF TGFBR2 TGFBR1 YWHAG RAS SIGNALING%WIKIPATHWAYS_20260211%WP4223%HOMO SAPIENS Ras signaling AFDN GNG3 GNG2 GNG5 GNG4 GAB2 GNG7 GNG8 ZAP70 KDR SHC1 KSR1 PDGFRA RRAS2 PLA2G2A SOS2 MET SHC4 LAT SHC2 PTPN11 SHC3 STK4 FLT3 FGFR2 PRKACG RAC3 PLA2G5 PLA2G6 PIK3R3 RAB5C PLA2G4B PAK6 PAK4 MAPK10 MAPK9 MAPK8 CALML6 CALML3 ARF6 CALML4 EXOC2 HTR7 RASGRP3 RAP1A RRAS PIK3R2 PIK3R1 RASGRF1 NF1 GRIN2B SYNGAP1 IKBKB ABL2 RAC1 HRAS KSR2 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D RALA PLA2G1B PLA2G4E PLA2G4C PLA2G3 EGFR PLA2G10 PAK1 FLT1 INSR RELA FGFR4 NRAS IGF1R GRIN1 RASSF1 AKT3 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAB5A BCL2L1 ETS2 RAF1 TNFSF6 EPHA2 PRKCB GNG10 GNGT2 PRKCA NTRK1 RASGRP4 KIT REL RASGRF2 TIAM1 RASA2 PIK3CD NGFR CHUK PLCG2 PLCG1 IKBKG RAB5B GNG12 GNG11 PIK3CA NFKB1 GNG13 CSF1R NTRK2 GNB2 ARHA GNB1 BAD PLA1A GNB4 RASAL1 GNB3 RASAL3 PLCE1 TTBK1 GNB5 RASA4B RALBP1 CALM1 PLAAT3 CDC42 RASA3 RASA4 RIN1 RAPGEF5 PLA2G2F PLA2G2E FGFR1 PLA2G2C FOXO4 PLD2 GNGT1 FLT4 RALB GRB2 SHOC2 SOS1 FGFR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST3B1 CHST7 EXT1 CHST1 CHPF CHST3 XYLT2 XYLT1 EXTL2 HS6ST1 EXTL1 HS6ST2 CHSY1 HS6ST3 CHSY3 CSGALNACT1 NDST3 CHPF2 B3GAT3 GLCE B3GAT2 B3GAT1 CSGALNACT2 B3GALT6 HS3ST1 HS3ST3A1 EXT2 UST CHST11 CHST12 HS3ST2 CHST13 CHST14 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 SMAD2 CASP9 CASP3 STAT1 BAX MRE11A CDC25B MSH6 RAD50 MSH2 BLM CDK4 MYC CDK2 CASP8 BARD1 ATF1 MAP3K5 BAD PLK1 BCL2 CDKN1B BBC3 NOXA1 MDM2 ATM ATR POU2F1 BACH1 CDKN1A PTEN BRCA1 RB1 JAK1 CDKN2B CDC2 CHEK2 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260211%WP2005%HOMO SAPIENS miR targeted genes in muscle cell SPRYD4 AP3D1 PHLDB2 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 LAMTOR3 LAMTOR5 TUSC2 LTN1 CPOX ARID4B CALCOCO2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ERBB3 POGLUT3 VPS39 KPNA3 EIF4E AXL MYLIP TPM3 TPM1 GRIA2 STX7 UBE4A ATG9A CDKAL1 RAB30 GPD2 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP MCL1 CCND1 CD164 BRPF3 HMGA1 SLC4A10 NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 CHMP2A SRPRB DKFZp761E1322 PICALM SLC25A1 DOCK5 TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 HSDL1 DSG2 ARID1A TXN2 RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 NXN UHRF1 HSD17B12 GNA13 DNAJB1 CAND1 PPP3CA POLR2C TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 CSF1 IRS1 MAPK12 MAPK14 PPIF MTRR LPL RTN4 KIT PRKCI COL3A1 DOCK7 RARS1 HEL-S-47e MAPK7 CDK6 E2F3 ITGB4 LAMC2 FGF2 P4HA2 NELFCD CDKN1A TMEM87A VSNL1 FSTL1 CA12 CAMTA1 ACVR1B PPIB HYAL3 ERBB2 CDKN1B LAMC1 C1QBP TNFRSF10B ITGA2 CCNG1 SNAP23 PTPRF COL1A1 SPARC SYPL1 THBS1 GPAM CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 GFPT1 ERG ATP6V0E1 CPNE8 VEZT TMEM41B EHMT1 SLC38A5 CLDN1 PWP1 ABCG2 KRAS CHORDC1 RAVER2 COL1A2 CIAO2A SEC62 NOTCH2 CDK5RAP3 NOTCH1 BCL2 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B GJA1 FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 HES1 HACD3 MRPL20 SLC7A11 BACH1 COMMD9 RDH10 GRPEL2 SNX6 SLC38A1 GSTM4 RAB27B MOV10 POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B RNP24 NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MRC2 PANX1 COIL SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC MRPS24 ATP2A2 ELMOD2 TMT1A AP3B1 SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN SSNA1 AMIGO2 NAPG HEL-S-66 PTPA NT5E PGRMC1 PPP1R7 USP1 SHOC2 SRSF10 MPZL1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260211%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide FAS IL12A VIP IL2 IL4 IL5 IFNG TGFB1 CD80 IL10 CTLA4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 POMC CDKN1B PPARG YAP1 CRP VEGFA CDKN1C INS FOS CDKN1A IL6 CREB1 BCL2L11 VAMP2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260211%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 EGFR RAF1 SMAD4 TGFB1 TGFBR3 AXIN1 NRAS TGFBR1 TSPAN8 CTNNB1 HGF MFGE8 DKK4 ERBB2 KRAS MET WNT3A HRAS MTOR TGFBR2 TGFA APC CD133 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP306%HOMO SAPIENS Focal adhesion MYL11 MYL5 MYLK MYL7 ITGB1 LAMB3 CCND2 TLN2 TXK LAMB2 MYL12A MYL12B MYL10 VASP SRMS CAV3 TNK1 PARVB VAV1 PARVG VAV2 ARHGAP5 DOCK1 SRC STYK1 KDR SHC1 c-fgr PDGFRA ZYX PDPK1 HGF ERBB2 FLNA MET FYN SHC4 SHC2 SHC3 PDGFC HEL-S-28 EGF ITGB3 ITGA2B CCND3 RAC3 LAMC1 PXN IBSP PIK3R3 ITGA1 PAK6 PAK4 PIP5K1C ITGA2 COMP BLK CCND1 ITGA4 MAPK10 COL1A1 ITGB7 LAMA5 MAPK9 MAPK8 PPP1CC THBS1 PPP1R12B HEL-S-80p VTN RAP1A PPP1R12C TLN1 PARVA CRKL SPP1 ACTN1 ACTN4 PIK3R2 PIK3R1 LAMB1 RAPGEF1 RASGRF1 PTEN RAC1 HRAS EGFR PAK1 TNC FLT1 PDGFA BRAF IGF1 VEGFA IGF1R CTNNB1 EMP2 AKT3 MAPK1 MAPK3 COL1A2 MYLK2 MAP2K1 PDGFD BCL2 RAF1 ACTG1 HEL114 PRKCB PRKCA COL2A1 ARHGAP35 MYL2 RELN VEGFB VEGFC GSK3B VEGFD XB PIK3CD TNR CRK COL4A2 BIRC2 ROCK1 COL4A1 BIRC3 ROCK2 JUN COL4A4 COL4A6 PIK3CA CAV2 CHAD ARHA BAD CDC42 FLNB COL5A3 COL5A2 ITGB5 ITGB4 TNK2 LAMC2 PS1TP5BP1 PTK6 ITGB8 ITGAV ITGB6 VAV3 VWF ITGA7 ITGA6 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 MYLK3 SOS1 THBS3 MYLK4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260211%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP661%HOMO SAPIENS Glucose homeostasis INS 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5408%HOMO SAPIENS 15q25 copy number variation AP3D1 TM6SF1 HTT SPCS3 HOMER2 AGAP2 RAMAC ZNF592 PDE8A RNMT WDR73 BNC1 BTBD1 GOLGA6L4 ADAMTSL3 SH3GL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB DNM3 RYR1 NMBR RYR2 EGF AP3B2 SPCS2 RAF1 SPCS1 ALPK3 ZSCAN2 SYNJ1 SHANK3 SHANK1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 CYP11A1 HSD11B2 SRD5A2 POR CYP21A2 STAR H6PD HSD3B1 HSD17B3 CYP17A1 CYP11B2 HSD3B2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4752%HOMO SAPIENS Base excision repair TDG POLE4 SMUG1 HMGB1 PARP2 PCNA PARP1 FEN1 MPG PNKP OGG1 UNG POLD3 POLD4 NTHL1 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 POLD2 NEIL2 APEX1 POLE3 IL19 SIGNALING%WIKIPATHWAYS_20260211%WP5422%HOMO SAPIENS IL19 signaling ACTA2 COL1A1 CXCR4 MAPK8 TGFB1 STAT1 STAT3 SOCS5 CCL11 TNFRSF1A NFKB1 IL4 SOCS1 IL19 CCNB1 MAPK1 TNF RAC1 MAPK3 JAK1 IL20RA MAPK14 IL20RB MUC5AC G13 SIGNALING%WIKIPATHWAYS_20260211%WP524%HOMO SAPIENS G13 signaling RHPN2 HEL-S-15 MYBPH PIK3CD CIT MAPK10 ARHGDIG WASL PIP4K2A MYL1 ROCK1 WAS ROCK2 SH3RF1 PIK3CA ARHGDIB HEL-S-80p LIMK1 ARHA PIK3R2 CDC42 CALM1 IQGAP1 TNK2 CYFIP1 RPS6KB1 PKN1 GNA13 ARHGEF1 RAC1 CFL2 PFN1 RTKN 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5400%HOMO SAPIENS 6q16 copy number variation LEP POMC GHSR GHRL MC4R SIM1 INSR LEPR BDNF INS NTRK2 AgRP NPY CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260211%WP5193%HOMO SAPIENS Cholesterol synthesis disorders EBP CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE HSD3B2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260211%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT2 GALNT16 GALNT1 B3GALT2 B3GALT1 B4GALNT1 B4GALT1 CERS3 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 KDSR T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VEGFD IDO1 TGFB1 CXCL12 PDGFA ARG1 VTCN1 VSIR TIGIT VEGFA B2M IL10 SHH TNFRSF4 HAVCR2 IL13 ENTPD1 TNFRSF9 FAS HLA-A PDCD1LG2 IL4 IL6 FAP NR1i1 PDGFD CTLA4 CCL17 PDCD1 PDGFC ICOS CCL22 TNLG5A CXCR4 LGALS9 CD40 TNFSF6 CD80 CD40LG TNLG2B CD226 NT5E VEGFB VEGFC NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP438%HOMO SAPIENS Non homologous end joining PRKDC POLL WRN POLM NHEJ1 XRCC5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260211%WP4549%HOMO SAPIENS Fragile X syndrome MMP9 CAMK2A CDKN2A BDNF SRC SHC1 AGAP2 HCN1 FYN RPTOR PTPN11 DEPTOR MLST8 EIF4E GRIA2 GAD1 EPHA4 RPS6KB1 RHEB AKT1S1 DAG1 TSC2 APP TSC1 ARAF ARC CLTB DLG4 CYFIP2 GRIP1 CPT1A SH3GL1 GRIP2 ARHGAP32 ABCD3 KCNC1 DLGAP3 TTI1 ALDH5A1 TBC1D7 PICK1 EPS8L1 NF1 CYFIP1 FMR1 GRIN2B SYNGAP1 PTEN PPP3CA SHANK1 SLC6A1 ALDH3A2 HOMER1 MAP1B PLCB1 BRAF CAMK1 AKAP5 GRIN1 MAPK1 KRAS KCND2 MAP2K1 MAP2K2 RAF1 EIF4G1 ABAT EIF4EBP2 DUSP3 PRKCA DICER1 EEF1A1 PRKAR1A TARBP2 AGO2 DKFZp762B153 GPHN RAP1GAP PLCG1 NTRK2 GABRG2 SH3GL3 MTOR EIF4A1 CLTC CLTA AP2A1 GABRB2 AP2S1 CLTCL1 PPP2R5B AP2M1 CREB1 CNR1 GRB2 SOS1 PTPN5 CAMK4 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism EBP CD36 CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR FDFT1 DGAT1 SQLE ABCG8 ABCG5 APOA4 MTTP APOB LDLR ACAT2 HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK MVD SLC27A4 SAR1B MGAT1 NPC1L1 FABP2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260211%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 PTGS1 NR1C1 MVD PTGS2 WNT1 VEGFA 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260211%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260211%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A CREBBP HDAC10 SRC STIM1 NRG1 GRM6 GRIA2 GRIN3B GRIN3A GAD1 GRIA3 GRIA4 SDCBP STAT3 CRTC1 HEL-S-162eP ARC PDIA2 DLG4 GRIP1 SLC6A13 DLGAP3 SLC6A11 PICK1 FRMPD3 ADARB1 CACNG8 SLC6A12 CACNG2 EFNB2 NETO2 CPEB3 CABIN1 ARHGEF9 GABRR3 SLC1A1 GRM3 GABRR1 NPTN NRXN3 GRIN2B ADIJ ADII NWD1 SLC6A8 SNX27 GLS2 ATAD1 SYVN1 LHFPL4 SLC6A1 SNX14 HOMER1 PLCB1 STAT1 CDH2 GRIN1 GRIK5 SLC1A2 GRIK3 GRIK1 MAPK1 GRM2 ERBB4 GRM4 MAPK3 GRM8 MAP2K1 FFAR1 ORAI1 MBD5 SUMO1 HDAC1 ABAT GNA11 SLC7A11 PRKCA PPP2CA DKFZp762B153 PIG59 GRIK2 GABRG2 SH3GL2 SLC1A3 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG1 SLC32A1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260211%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH2 CS ALDH3A2 ACSS2 ACO2 ALDH9A1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer TIGIT PRF1 FOXO1 GATA2 MYC CCL5 TNF CCL2 CCL4 CCL1 ADAM17 ADAM10 FCGR3A IFNG CD226 CSF2 MICA BMI1 KLRK1 NCR3LG1 MICB CD96 NCR1 CCL3 NCR3 COPPER METABOLISM%WIKIPATHWAYS_20260211%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 ATP7A SLC11A2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK10 MAP3K21 MAPK9 MAPK8 ARAF BRAF MAP3K1 PARP14 MAP2K3 MAPK1 MAP2K4 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 PARP1 RAF1 MAP3K8 MAP3K7 MAP3K12 TNKS ATF4 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CSF2RA LAG3 TGFB1 CXCL12 CCR2 VEGFA NRP1 HLA-DRB1 KDR FAS CSF1R IFITM2 CSF1 CCL5 CCR5 BAG3 HLA-DRA CCL2 CTLA4 CXCR4 TNFSF6 CD80 ITGB6 CSF2 CXCR3 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN1 PLAGL1 PCM1 ACTR1B KIAA0753 CEP170 BMERB1 DCTN6 OFD1 NDE1 ABCC6 DCTN4 MARF1 CEP20 DCP1A GATA3 ACTR10 DCP2 RAPGEF4 RAP1A DISC1 PLK1 ABCC1 PAFAH1B1 PLAG1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260211%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 PIK3R5 CACNA1A PRKCZ MAPK8 INSR PDX1 SLC2A2 SURF1 PHKA2 IRS1 IKBKB SOCS4 MAPK1 TNF INS-IGF2 MAFA MTOR FOXP3 IN COVID 19%WIKIPATHWAYS_20260211%WP5063%HOMO SAPIENS FOXP3 in COVID 19 FOXP3 IL6R IL2 IL7R IL6 IL2RG STAT3 STAT5B CD80 IL2RA IL6ST IL2RB CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260211%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKB1 IKBKB CHUK RELA REL NFKBIA IKBKG NFKBIE ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260211%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260211%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 LMF1 LDLR PLTP GPIHBP1 LPL ANGPTL4 APOA5 ANGPTL8 APOC2 ANGPTL3 LIPC APOA2 SEL1L RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260211%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 RALBP1 EXOC2 EXOC8 YBX3 KRAS RAC1 NRAS RAC3 HRAS RALA WNT SIGNALING NETPATH%WIKIPATHWAYS_20260211%WP363%HOMO SAPIENS Wnt signaling NetPath GSK3B MAPK9 MAPK8 TSC2 CSNK1D TSC1 CSNK1G1 AXIN1 ROR2 FRAT1 CSNK1A1 CSNK1E CTNNB1 LRP5 NLK MAPK1 LRP6 SOX1 ARHA RYK NFATC2 ROR1 PI4K2A MTOR APC CDK6 CTBP1 BCL9 ARRB2 PPARG LEF1 PRKCB GSK3A MAP3K7 TCF4 DVL1 STM7 DVL2 TCF7L2 PRKCA TCF3 DVL3 RAC1 CCND1 GCKR ATR SIGNALING%WIKIPATHWAYS_20260211%WP3875%HOMO SAPIENS ATR signaling RAD1 RAD9B CHEK1 RAD9A ATRIP RPA3 RPA1 HUS1 ATR TOPBP1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260211%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis GPC6 COL1A1 COL3A1 SPARC YAP1 SNAI2 EDNRA TEAD4 TWIST1 PBX3 THBS2 TEAD2 TEAD3 NRF2 PATHWAY%WIKIPATHWAYS_20260211%WP2884%HOMO SAPIENS NRF2 pathway ABCC5 HGF NRG1 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 TGFB1 TXN SERPINA1 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 SLC2A3 GSTM3 SLC2A2 ABCC3 SLC5A1 HEL-S-128m SLC6A5 SLC5A2 SLC6A7 SLC6A20 SLC6A8 SLC6A9 DNAJB1 SLC5A5 GSTM5 SLC6A1 EGR1 SLC6A2 TGFBR2 SLC2A14 SLC6A19 SLC2A11 UGT2B7 ABCC2 SLC2A10 SLC6A18 SLC2A13 SLC2A12 GSTM1 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC5A8 HBEGF RXRA HEL-75 GCLC GSTM2 NFE2L2 GSTA5 GSTA4 CYP2A6 GSTA3 SLC6A3 SLC39A9 UGT1A1 EPHA2 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC7A11 ALDH3A1 FTH1 SLC39A8 SLC2A9 GSTM4 SRXN1 SLC2A6 SLC2A7 SLC2A8 KEAP1 MAFG ME1 SLC39A14 GPX2 HEL-S-25 FTL HEL-S-22 SLC5A12 SLC5A10 HMOX1 UGT1A4 UGT1A7 TXNRD3 MAFF ADH7 GCLM FGF13 HSP90AB1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 NFKB2 APP PSEN2 SIRT1 PSEN1 GDF8 PSENEN BACE1 ID SIGNALING%WIKIPATHWAYS_20260211%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 ID2 ID3 CCNE1 ID1 PAX8 RBL2 RBL1 RB1 CDK2 PAX2 MYOD1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260211%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGV PIGY PIGM PIGC DPM2 PIGB PIGW PIGA PIGK MPPE1 PIGL PIGF PIGH PIGX CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260211%WP2029%HOMO SAPIENS Cell differentiation index TLX2 HDAC5 STAT3 LEFTY1 TLX1 TLX3 LEFTY2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX12 LTC4S PTGS2 ALOX5 ALOX15B ALOX15 ALOX5AP PLA2G5 PLA2G6 PTGS1 PTGIS PLA2G4B PRXL2B PTGES OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP3941%HOMO SAPIENS Oxidative damage response MAPK10 CASP9 CASP3 BAK1 APAF1 TRAF3 TRAF2 TRAF6 C5AR1 MAP3K1 CDKN1C NFKB1 MAP2K4 TNF MAPK13 BAD GADD45A PCNA C1R CDC42 BCL2 CDKN1B C1QB C1QA TNK2 C4B_2 C2 CDKN1A C3AR1 TNFRSF1B BAG4 CR2 TRAF1 NFKBIE CYCS C1QC HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260211%WP4540%HOMO SAPIENS Hippo signaling regulation PLCB4 PRKD3 PLCB1 EGFR SMAD2 PLCB2 FLT1 INSR CDH6 FGFR4 CDH2 CDH16 IGF1R KDR PDGFRA CTNNB1 PRKAA2 MET PRKAG1 FLT3 PRKAG2 PRKAG3 FGFR2 PRKAA1 LEF1 PRKACG EPHA2 PRKAB2 PRKCH PRKCB PRKAB1 GNA11 PRKCE PRKCA NTRK1 TCF7L2 TCF7L1 CDH9 KIT CDH8 PRKAR1B GNAL PRKAR1A CDH4 PRKCI CDH10 PRKCQ CDH11 CDH12 CDH15 CDH17 CDH19 NF2 PRKCZ CDH24 NGFR WWTR1 YAP1 GNAI3 CSF1R NTRK2 ARHA GNAS MTOR CDC42 FGFR1 FLT4 CDH18 LATS1 PLCB3 TEAD4 LATS2 RAC1 TEAD2 TEAD3 FGFR3 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CCND2 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 TFAP2A WNT5B WIF1 SOST LEF1 CCND3 NKD1 NKD2 MAP3K7 DVL1 DVL2 TCF7L2 TCF3 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 MACROH2A2 ATF3 CXXC4 PORCN GSK3B CDK8 WNT2B HNRNPK NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 FRAT1 FRAT2 AXIN2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CDK6 CTBP1 FOSL1 FZD1 RUVBL1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 APC2 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP5172%HOMO SAPIENS Iron metabolism disorders TF PANK2 CYBRD1 HFE2 HAMP HEPH FTL STEAP3 FTH1 UQCRFS1 CP TFRC HFE TFR2 SLC40A1 SLC11A2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260211%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 PPP5C TSC2 PPM1D RBBP8 RNF20 MRE11A MDC1 ATMIN RIF1 CEP63 IKBKG KAT5 TRIM28 RAD50 TP53BP1 NFKB1 LMNB2 CDK2 NHEJ1 MAPK12 MAPK13 ATF2 MAPK11 MAPK14 MTOR PRKDC HMGN1 ATM RNF168 NBN ATR SMC1A RNF8 AURKB HEL-S-102 PPP2CA STK11 CDK5 CHEK2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2B P2RY6 P2RY4 P2RY2 P2RY1 LPAR4 ADORA2A LTB4R SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260211%WP615%HOMO SAPIENS Senescence and autophagy in cancer SERPINB2 IRF7 CDKN2A SMAD4 INHBA BRAF IGF1 CEBPB IGF1R IL24 SRC INS MAP2K3 MAPK1 MAP2K1 MAPK14 LAMP2 IL6ST MLST8 BCL2 RAF1 ATG3 CDKN1B GABARAPL2 PLAT ATG12 SLC39A2 IGFBP5 SLC39A1 ATG16L1 SLC39A3 AKT1S1 IRF1 IL6R MAP1LC3A MAP1LC3C SQSTM1 IFNG RB1 SH3GLB1 UVRAG ATG10 BMP2 GSK3B HMGA1 CD44 COL1A1 DKFZp762B153 COL3A1 RB1CC1 SPARC TGFB1 CDC25B JUN ING1 COL10A1 GABARAPL1 THBS1 TNLG1B ATG14 ATG5 RNASEL VTN IL6 GABARAP CXCL8 AMBRA1 IFI16 CREG1 RSL1D1 ULK1 MTOR IL3 PCNA MDM2 KMT2A CDKN1A PTEN IFNB1 IL1B BMI1 HRAS CXCL1 CXCL14 IGFBP7 IL1A MMP14 CCL3 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP69%HOMO SAPIENS T cell receptor signaling PAK1 RELA HEL-S-81p GAB2 VAV1 SH2B3 ZAP70 GRAP2 SHC1 PDPK1 LCP2 CARD11 BCL10 MAPK1 FYN MAPK3 NFATC2 LAT ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 RAF1 MAP3K8 MAP3K7 REL PTK2B PRKCQ LCK MAP4K1 MAPK9 MAPK8 CD3G CD3E CHUK CD3D CD8A TRAF6 CRK IKBKG WAS PLCG1 JUN NFATC1 NFKB1 MAP3K14 ITK CRKL PSTPIP1 RIPK2 FYB1 PIK3R2 PIK3R1 CDC42 ICOS CBL NCK1 VAV3 FOS IKBKB CREB1 HRAS GRB2 SOS1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260211%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts GCK GLS UGDH LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 CD36 BMP1 FGFR1 GLUD1 FGFR4 PSAT1 PLCG1 P4HA2 PSPH ALDH18A1 HEL-S-133P ARHA PHGDH P3H4 P3H3 PLOD1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260211%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR AGXT GLYCTK AQP9 KHK GPD1 LIPE ALDOB PC FBP1 GPD2 PFKL HEL-S-162eP ENO1 HEL-S-68p MGLL HEL-S-165mP PGAM1 HEL-S-49 G6PC1 HEL-S-87p PNPLA2 AQP7 PCK1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260211%WP2889%HOMO SAPIENS Oxytocin signaling OXTR PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CASP9 CASP3 APAF1 PINK1 UBE2L6 PARK2 UBE2L3 CASP2 DDC MAPK12 MAPK13 MAPK11 MAPK14 GPR37 UBB SEPT5 LRRK2 SLC6A3 ATXN2 HEL-S-67p CASP6 CCNE1 UBA7 TH EPRS1 SYT11 HEL-117 UBE2J2 CCNE2 UBE2J1 SNCA HTRA2 UBE2G1 UBE2G2 SNCAIP CYCS IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFD MMP9 TGFB1 CXCL12 VEGFA IL10 IL13 IL2 IL4 IL6 IL5 CXCL8 CCL5 TNF CCL28 CCL2 CXCL5 CCL20 LGALS9 IL25 REG4 IL12B IL12A IFNG IL23A IL1B IL17F CSF2 IL17D IL17C IL17B CXCL1 VEGFB IL17A VEGFC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 YES1 WWTR1 H4C9 SRRT FGF7A HIST1H4L SOX12 POU3F1 UTF1 SOX15 ZSCAN10 SOX4 SOX2 TEAD2 POU3F2 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP531%HOMO SAPIENS DNA mismatch repair PCNA POLE4 RFC2 MSH6 RFC3 RFC4 RFC1 POLD3 MSH2 POLD4 POLE LIG1 PMS2 POLE2 POLD2 POLE3 RPA3 RPA1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260211%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP8 ATP6 COX17 ATP5MC2 ATP5J ATP5MC3 COX7A2 ATP5H COX11 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 SLC25A14 COX2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HEL-S-123m SLC25A27 UCP3 UCP2 NDUFA7 NDUFA6 NDUFA5 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX4I1 COX6A1 COX8A COX6B1 COX7A1 SDHC SDHD UQCRB SDHB COX3 UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 UQCRC2 SURF1 COX1 SDHA SLC25A5 SLC25A4 SLC25A6 UCP1 NDUFA13 COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 NDUFA9 NDUFA12 NDUFA10 COX6A2 HEL-S-271 ATP5IF1 COX7A2L SCO1 ND1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260211%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ACTA2 ITGB1 MAPK10 ITGB7 NF2 MAPK9 MAP4K1 MAPK8 PAK1 MAP4K2 WWTR1 YAP1 MAP4K3 SRC CTNNB1 CTNNA1 ACTG1 ITGB5 ITGB4 ITGB3 YWHAQ PS1TP5BP1 ITGB8 SGMS1 ITGB6 ACTA1 LATS1 LIMD1 TEAD4 PAK6 PAK4 TEAD2 TEAD3 HEL-S-31 ACTG2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 EGF ZEB2 LTBP1 ZNF423 BAMBI LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP4262%HOMO SAPIENS Breast cancer pathway SHC1 ERBB2 SOS2 SHC4 SHC2 SHC3 EGF RPS6KB2 E2F2 RPS6KB1 NBN DDB2 PIK3R3 RB1 CETN3 GADD45B GADD45G CCND1 ARAF BAX FZD10 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B GADD45A PIK3R2 PIK3R1 TNFSF11 FZD1 WNT10B WNT10A FZD3 ATM FZD2 FZD5 FZD7 FZD9 ATR FZD8 PTEN BRCA1 BRCA2 HRAS APC2 NCOA1 FGF23 EGFR BAK1 MRE11A BRAF NRAS IGF1 CSNK1A1 WNT7B IGF1R WNT7A RAD50 RAD51 FGF10 CTNNB1 CDK4 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 NR3A2 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 PGR RAF1 LEF1 HES1 DVL1 HES5 DVL2 FGF8A TCF7L2 DVL3 NFKB2 TCF7L1 WNT1 KIT WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD POLK AXIN1 AXIN2 SKP1 JUN WNT16 PIK3CA SP1 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC CSNK1A1L CDK6 JAG2 E2F3 PARP1 FGF18 FGFR1 FLT4 HEY2 FGF2 FGF7B FGF7A FOS DLL3 DLL4 CDKN1A FGF5C GRB2 SOS1 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260211%WP4331%HOMO SAPIENS Neovascularization processes MMP9 SMAD2 ANGPT1 MAPK9 MAPK8 KITLG TGFB1 RELA CXCL12 RELB TGFBR1 DKFZp781O1323 KDR NFKB1 MAPK1 MAPK3 SMAD1 NOTCH3 NOTCH1 SMAD9 CXCR4 EPHB4 FLT4 EPHB2 DLL4 NFKB2 HIF1A KIT ACVRL1 REL CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260211%WP5603%HOMO SAPIENS Caffeine in myocytes MYL11 TNNT1 ACTA2 MYL3 TNNT3 MYH8 MYH4 MYH7 MYL1 TNNC1 TNNI1 HEL-S-273 HEL-S-108 RYR1 RYR2 ACTG1 TPM3 TPM1 RYR3 PS1TP5BP1 MYH6 ACTA1 MYH13 TNNI2 MYL2 TNNI3 TNNC2 MYH1 ACTG2 MYH2 MYL6 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260211%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine AANAT SPR PAH MAOA ASMT JDP1 PTS PNMT TH DHFR DBH NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IRF7 RELA DDX3X TRAF3 CASP10 MAP3K1 ISG15 TNF IFNK MAPK12 MAPK13 MAPK11 MAPK14 NFKBIA TBKBP1 NFKBIB IKBKE ATG12 MAP3K7 IFNE RIPK1 IFNG TANK MAPK10 MAPK9 MAPK8 OTUD5 CHUK CXCL12 TRAF2 TRAF6 DDX3Y TBK1 DHX58 IKBKG TRIM25 AZI2 SIKE1 RNF125 NFKB1 CYLD PIN1 ATG5 CXCL8 MAVS SNW1 CASP8 RIGI FADD TRADD IFNB1 IKBKB MITA NLRX1 IFNA1 IFIH1 IRF3 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 LBR HMGCR NR1H2 CH25H FDFT1 IDI2 PLPP6 FADS2 SCD CYP7A1 CYP27A1 MYLIP ELOVL5 ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK HMGCS1 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP623%HOMO SAPIENS Oxidative phosphorylation ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP6 ATP5MC2 ATP5J ATP5MC3 ATP5H NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 HEL-S-123m NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COXFA4L2 ATP6AP2 NDUFS8 NDUFS3 COXFA4 NDUFA11 NDUFA9 NDUFA10 HEL-S-271 ND1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260211%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 NF1 KRAS NRAS BRAF HRAS PTPN11 GRB2 SOS1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260211%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling GSK3B CREBBP CASP9 PDGFA IKBKG FOXO1 PIK3CA NFKB1 CTNNB1 AKT3 KLK3 MAPK1 KRAS BAD MAP2K1 MTOR NFKBIA MAP2K2 BCL2 RAF1 CDKN1B MDM2 CDKN1A GRB2 CCND1 SOS1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IF2B1 IL23R IL17RC STAT3 IL12RB1 IL12B TYK2 CXCL8 IL23A IL1B IL17F HLA-C TNF CCL20 CXCL1 IL17A CCR6 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260211%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction CALM1 RYR1 MYLK PLCB1 PPP1R14A MYL1 ROCK1 ROCK2 IL13 GDI1 ADRB2 HEL-S-80p ARHA OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260211%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 NFKB1 IKBKB CHUK MAPK1 RELA ITGB3 MAP3K14 SPP1 MAPK3 MAP2K1 ITGAV HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260211%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG3 RB1CC1 ATG12 WIPI1 ATG16L1 MAP1LC3A ATG5 ZFYVE1 ATG16L2 ATG10 ULK2 MTOR ULK1 PIK3R4 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260211%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP8B1 ABCC2 AKR1D1 AKR1C4 SLC27A5 SLC51A HSD3B7 ABCB4 SLC51B ABCB1 BAAT ABCC3 CYP7B1 SLCO1B1 FABP6 SLC10A2 AMACR ABCB11 SLC27A2 ATP8B1 HSD17B4 CYP7A1 ABCD3 CYP27A1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP496%HOMO SAPIENS Steroid biosynthesis CPN1 HSD17B2 F13B HSD3B1 HSD17B3 HSD17B7 CYP17A1 HSD17B4 HSD17B1 HSD3B2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB4 PIK3CD PLCB1 PLCB2 TSC2 TSC1 YAP1 ROCK1 PKN2 PIK3CA AKT3 MAPK1 ARHA MTOR PIK3R2 MOB1A PIK3R1 PKN3 PKN1 PIK3R3 LATS1 PLCB3 TEAD4 LATS2 TEAD2 TEAD3 TRIO SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1A2 MSRB2 CYP1B1 MSRB3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260211%WP2197%HOMO SAPIENS Endothelin pathways CALCA HEL-S-14 MYLK PLCB1 GNAI1 MYL1 CAD HEL-S-7a GNG13 EDNRA RAMP1 GNA15 MAPK1 NPY GNAS MAP2K1 COX2 CALCRL GNB5 ECE1 EDNRB CALM1 ADRB1 NPY1R RIIAD1 ATP2A2 RAF1 ADRA1A EDN1 PRKCA PTGIR LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 CS SLC19A2 NONO SIGNALING LIPIDS%WIKIPATHWAYS_20260211%WP5584%HOMO SAPIENS Signaling lipids PLA2G1B CYP2C8 CYP8B1 COX1 PLCB1 ALOX12 LTC4S PTGS2 CYP2C9 ALOX5 CYP2B6 ALOX15 HPGD CYP7B1 CYP4F2 GPX4 FADS2 PLA1A CYP7A1 EPHX2 PRXL2B CYP27A1 PTGES VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260211%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism HEL-S-53e RXRB CD36 RXRG HEL-S-4 CYP26A1 SULT1A1 SULT2B1 ADH1A CYP26B1 RLBP1 RPE65 DGAT1 SDR16C5 RXRA MAPK1 RDH12 ABCG8 AWAT2 ABCG5 LRAT BCO1 SCARB1 RDH8 ALDH1A3 CRABP2 RETSAT RARA CRABP1 LPL DHRS3 RBP7 RBP4 RBP2 RBP1 RDH5 CYP2E1 ALDH1A2 NR1B3 RDH10 NPC1L1 RARB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA5 ST3GAL5 A3GALT2 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 FUT1 ST8SIA1 SLC33A1 B3GALT4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3930%HOMO SAPIENS EDA signaling in hair follicle development BMP1 TNLG7C DKK1 EDARADD DKK4 LTB WNT3 PTCH1 RELB EDAR SHH SOSTDC1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260211%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH GH1 GNRH1 SST IGF1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260211%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC5A1 HEL-S-53e GLYCTK KHK HEL-S-49 SORD ALDOB G6PC1 FBP1 PFKL SLC2A2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP707%HOMO SAPIENS DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260211%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2 TMEPAI NEDD4 TGFBR2 TGFBR1 ATG16L1 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP411%HOMO SAPIENS mRNA processing SRPK2 PPM1G RNMT YBX1 SUPT5H HNRNPH1 NCBP1 NCBP2 SMC1A SRSF9 TMED10 PTBP1 METTL3 SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A NONO PSKH1 SNRPN PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 HNRNPD SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA FUS SNRPB DHX8 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 CPSF3 WDR57 SFRS3 CLK4 SFPQ LSM2 CLK2 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 DHX16 RBM5 RBM17 PRMT2 PRMT1 PRPF18 NHP2L1 SNRPA1 DNAJC8 SF3B5 SF3B2 DICER1 CSTF2T U2AF1 PABPN1 POLR2A U2AF2 TRA2B SNRPB2 SF3B1 DDX1 SF3A1 SF3A2 HNRNPK SPOP HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SRPK1 SRP54 DHX15 PRPF40A SRSF10 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260211%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCB4 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 RETN RELA CHUK PLCG2 PLCG1 IKBKG PIK3CA NFKB1 IL6 AKT3 CXCL8 MAPK1 TNF MAPK3 MAPK14 NFKBIA PLCE1 IL12B IL12A PLCB3 IKBKB LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3624%HOMO SAPIENS Lung fibrosis MMP9 CXCL2 CCR2 PDGFA IGF1 CEBPB CCL11 HGF CCL5 TNF SFTPC CCL2 CCL4 TGFA EGF BMP7 NFE2L2 IL12B TERT TIMP1 CALCA TGFB1 CSF3 FAM13A SFTPA2 MT2A KPG_011 ATP11A CTGF RTEL1 DPP9 STN1 CMA1 IL13 MUC5B HMOX1 IL4 IL6 IL5 SERPINA1 CXCL8 SPP1 FGF7 CCR3 ELMOD2 PTX3 SFTPA1 FGF2 GREM1 EDN1 MMP2 IL1B CSF2 SKIL CCL3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GCK HEL-S-162eP PFKL ENO1 ENO2 PFKM ENO3 HEL-S-68p MPC2 PGAM2 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-30 HEL-S-87p HK2 PCK1 SLC2A4 PDHA1 MDH2 GOT2 PKLR ALDOB PC FBP1 SLC2A3 SLC2A2 LDHB MPC1 HEL-S-133P DLAT HK3 G6PC1 HEL-S-32 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260211%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO GOT2 AGXT SLC26A1 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260211%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates FBP1 VEGFA FOXO1 PIK3CA HEL-S-68p KDR MYC HIF1A PGAM1 HEL-S-133P OTUD7B G6PC1 OTUB2 USP37 U2AF2 USP44 SIRT7 MTOR HK2 VHL USP28 USP19 OTUD6B ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260211%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTBN4 KCNQ2 BRSK1 SEMA3A ANK2 L1CAM SCN5A SPTAN1 PRRT2 CSNK2A1 EIF2A CSNK2A2 SCN2A DDIT3 CSNK2B SNAP25 ATF4 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260211%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap MTR CTH GCLM CBS METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 ANXA2 MTTP APOB LDLR APOE LPL ABCA1 LIPG APOC2 LIPC APOA2 PCSK9 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer BIRC5 HEL113 APP AXIN1 HEL-S-89n NFKB1 THBS1 SOCS3 NRG1 YBX3 MAPK1 JUND TNF RIPK2 F2R ERBB3 GCLC ERN1 CTNNA1 IL7R CDKN1B CUL5 APOE BEX3 RNF7 NQO1 HELLS HDAC1 NET1 CARD14 TNFRSF21 RPS6KB1 PKN1 VAV3 HEL-S-7 CDKN1A SQSTM1 HEL-S-102 PTK2B TNFRSF10B TRAF1 HSPD1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DYNC1H1 DCTN1 YWHAQ DCTN6 TH PAFAH1B1 DCTN5 DCTN3 HEL-S-1 YWHAG NDEL1 DCTN4 HEL-S-77 YWHAZ DDC PPP2CA HEL2 CDK5 DBH DISC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MYLK PIP4K2A VAV1 DOCK1 PDGFRA RRAS2 SOS2 WASF1 EGF FGFR2 RAC3 PXN PIK3R3 STM7 ITGA1 PAK6 PIP5K1A PIP4K2B PAK4 PIP5K1C MYL3 WAS ARHGEF4 RRAS CYFIP2 BDKRB1 PIK3R4 ACTN1 PIK3R2 PIK3R1 GNA13 RAC1 APC2 CD14 FGF23 EGFR PAK1 MYL1 FGFR4 ARHGEF7 PDGFA BRAF NRAS CHRM1 FGF10 BDKRB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAF1 ACTG1 HEL114 F2 FGF8A ARHGAP35 CFL2 FGF6B PFN1 EZR HEL-S-15 PIK3CD CHRM2 CHRM3 CRK ROCK1 ROCK2 GNG12 PIK3CA TMSB4X LIMK1 ARHA FGF20 FGF22 FGF7 FGF21 FGF8 F2R FGF9 FGF16 APC FGF14 CDC42 PIK3R5 FGF13 FGF18 FGF12 IQGAP1 FGFR1 PIK3C2G PIK3C2A PIK3C2B PS1TP5BP1 FGF2 FGF7B NCKAP1 CHRM4 FGF7A CHRM5 HEL70 MYH10 RDX RASSF7 ARHGEF1 ARPC5 MAPK6 SSH2 SSH3 MAPK4 BRK1 FGF5C PIP5KL1 FGD1 CSK WASF2 BAIAP2 MOS SOS1 ABI2 FGFR3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC2 NFE2L2 MAPK8 HEL-S-22 NQO1 CES1 ABCC6 JUN ABCC3 FOS HMOX1 ABCG2 EPHX1 MAPK12 MAPK13 SRXN1 MAPK11 GCLM MAPK14 NQO2 KEAP1 GCLC IL26 SIGNALING%WIKIPATHWAYS_20260211%WP5347%HOMO SAPIENS IL26 signaling MMP9 ACTA2 RORC DCSTAMP SMAD2 MAPK9 MAPK8 CASP3 RELA STAT1 STAT3 BAX IL10 JUN NFATC1 PIK3CA TYK2 ATP6V0D2 SOCS3 IL6 CXCL8 MAPK1 TNF DDIT3 MAPK3 MAPK14 NFKBIA COX2 CCL20 IL33 TNFSF11 EPHA3 DEFB4B MPO CTSK IL10RB IL1B CSF2 JAK1 IL20RA IL17A IF2G MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260211%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IRAK1 TIFA TLR4 UBE2V1 MYD88 TRAF6 TLR1 JUN NFKB1 TLR10 TLR5 HEL-S-71 TLR9 TLR8 TLR7 IL1A HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260211%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells KIR2DL1 KIR2DL3 ELF3 NLRP7 NLRP2 VAV1 PLCG1 PRKCA LCP2 IFNG CSF2 HLA-C TNF RAC1 FYN LAT TYROBP PRKCQ SYK PTPN6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP170%HOMO SAPIENS Nuclear receptors NR1D2 RORC RORA RXRB NR2F6 RXRG NR2E1 NR2F1 NR0B1 NR5A2 NR1H2 NR1C1 NR1A2 RXRA NR1I3 NR1i1 NR5A1 ROR1 NR2F2 NR3A2 NR1i2 PGR RARA NR2C2 NR2A1 PPARG NR3C1 ESRRB NR1C2 NR1B3 NR1H3 THRA ESRRA RARB FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260211%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 LMF1 LDLR PLTP GPIHBP1 APOA5 APOC2 LPL LIPC APOA2 SEL1L SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP15%HOMO SAPIENS Selenium micronutrient network SELENOK PTGS2 RELA INSR CRP HEL-S-97n FLAD1 PRDX3 PRDX5 INS HEL-S-2a TNF GPX1 CCL2 HEL-S-44 HEL-75 SCARB1 APOB SERPINA3 LDLR SAA4 HBB MTR PLAT PLG HEL-S-302 SELENOF MPO SELENOI SELENOH ABCA1 SEPHS2 FGA HBA2 GPX6 F2 PTGS1 SELENOO HEL-S-78p NFKB2 F7 SELENON IFNG SELENOM ALB SELENOP SAA1 SELENOW SAA2 GPX4 SELENOV SELENOT MSRB1 SELS GPX2 ALOX5 ALOX15B ALOX5AP DIO1 CBS TXN NFKB1 TXNRD3 IL6 CTH XDH GPX3 TXNRD2 IL1B KMO KYNU DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260211%WP5195%HOMO SAPIENS Disorders in ketolysis OXCT1 HMGCS1 ACAT1 ACAT2 BDH1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 HFE2 HAMP BMP6 ID1 HFE TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma ELOC BIRC7 CREBBP TGFB1 EP300 TFEB VEGFA CTSK SETD2 FH CADM2 DVL2 ARNT2 CDKN1A PRCC RBX1 COL21A1 EGLN1 HIF1A EGLN3 EGLN2 VHL TGFA SFPQ BENZENE METABOLISM%WIKIPATHWAYS_20260211%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH NQO1 GSTM1 MPO CYP2E1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4224%HOMO SAPIENS Purine metabolism and related disorders XDH ADA DGUOK HPRT1 TPMT RRM2B ADSL HEL-S-70p PNP MOCOS AMPD1 PFAS PAICS APRT AOX1 IMPDH1 ADSS 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260211%WP5546%HOMO SAPIENS 22q11 2 distal CNV SDF2L1 CAMK2A NEDD4 PPIB RPS15 RPS14 RPS17 RPS16 RPS18 RPS10 RPS13 RNF19B RPS12 VPREB1 RPS9 CWC22 AQR RPS7 RPS8 CRNKL1 RPS5 PDIA4 RAB36 DNAJB11 RPSA PPIE RPS6 SNRNP200 GNAZ CD79B UBA6 CABP1 CD79A AK8 CWC15 TDRD3 GGTLC2 ZNF280A RPS15A HEL-S-107 RPS19 ARIH1 RPS3 CCDC116 BUD31 RPS2 PLRG1 YDJC RBM22 LRP4 PPM1F RNF113A RILP UGGT1 RPS26 PPIL1 CDC5L RPS28 IGLL5 XAB2 CHEK1 RPS29 YPEL1 PPIL4 RPS20 PPIL6 RPS21 RPS24 RPS23 IGLL1 PARK2 UBE3A UBE2L3 HEL-S-89n IQUB HEL-S-99n ROPN1L RSPH6A PDIA2 DNAJB13 NME5 DYDC1 RSPH9 RSPH3 MDM2 XBP1 RSPH14 SNRPD2 SNRPD1 SNRPD3 PAK1 SNRPG SNRPE SNRPF CAMK1 SNRPB FAU PRPF8 MAPK1 WDR57 HEL-S-125m DHX16 RPS11 RPS27A SNRPA1 SF3B5 SF3B2 SNRPB2 SF3B1 SF3A1 ELOC SF3A2 PHF5A HYOU1 RBX1 SNW1 CANX BCR SOX9 CBL PTPA CAMK4 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260211%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy STX1A CAMK2A DAG1 RAB1A SCN8A ZNF547 TRAPPC3 PRRT2 GIGYF1 TRAPPC6B KCNQ5 NEDD4 AKAP5 SCN2A SCN4B RAB11A SNAP25 KCNQ2 CALM1 KCNQ3 FGF13 FGF12 PRKCE BACE1 VAMP2 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism CYP11A1 SRD5A2 HSD17B2 HSD3B1 HSD17B3 SULT1A1 UGT1A1 CYP17A1 HSD3B2 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation NCKAP1L VAV1 GATA2 KLF1 CSF1 CD34 NFATC2 MYB NOTCH1 MUC1 CXCR4 RUNX1 SPI1 ITGB3 LEF1 ITGA2B XB KITLG CSF3 EPO TRAF3IP3 IKZF1 HMGN5 TRIM29 LMO2 CBFA2T3 ZNF835 GATA1 ABO MXI1 NFE2 IL6 IL5 RIOK3 NR1A2 MHC2TA FLI1 ARHH GP9 TPO HES6 IL3 PIM1 LYL1 FOS IL1B CSF2 ACVR1B FOSB IL1A EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260211%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NLRP3 IL1B PRKAR1B PRKAR1A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CSRP2 CTNNB1 CDK4 SOX4 RB1 PMAIP1 MACROH2A1 CCND1 MED1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260211%WP5604%HOMO SAPIENS Sickle cell disease HBA2 TLR4 IL18 HBB IL1B BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260211%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 LDLR FGF8A ABCB11 MAPK1 FGFR4 ABCG8 MAPK3 ABCG5 FXR1 CYP7A1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP581%HOMO SAPIENS EPO receptor signaling RAF1 EPOR STAT1 STAT3 CISH EPO SRC SHC1 SOCS1 IRS1 PTPRC MAPK1 STAT5B MAPK3 PTPRU MAP2K1 GRB2 MAP2K2 SOS1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260211%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER1 PIK3CD PTGER3 EGFR PTGS2 BRAF NRAS SRC PIK3CA AKT3 MAPK1 KRAS PTGER4 MAPK3 HRAS PLA1A PTGER2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR STAT3 MAPK1 MAPK3 JAK1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260211%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL6 STAT2 HEL-S-10 STAT1 STAT3 JAK1 IL10 IL10RB IL10RA IL1A CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CD EGFR NRAS IGF1R INS PIK3CA CDK4 AKT3 IRS1 ERBB2 CDK2 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 PIK3R5 CDK6 RAF1 CDKN1B PIK3C2G PIK3C2A PIK3C2B CCNE1 PIK3R3 CDKN1A HRAS CCND1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP2855%HOMO SAPIENS Dopaminergic neurogenesis HEL-S-53e TGFB1 ASCL1 STAT3 CDKN1C NKX2-2 SHH DDC GBX2 MSX1 SOX2 FGF8 NKX6-1 PITX3 EN2 EN1 LMX1A LMX1B OTX2 FOXA2 SLC6A3 TH NEUROD1 NEUROG2 SLC18A2 WNT1 RET GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260211%WP2261%HOMO SAPIENS Glioblastoma signaling CDKN2A CCND2 EGFR EP300 NRAS BRAF FOXO1 IGF1R SRC PDGFRA PDPK1 CDK4 AKT3 IRS1 MAP2K3 ERBB2 CDK2 MAP2K4 MAPK1 KRAS MET MAPK3 MAP2K6 MAP2K1 MAP2K2 ERBB3 RAF1 CDKN1B FGFR2 PRKCH PRKCB PRKCA RB1 CDKN2B PRKCI PRKCQ CDKN2C CCND1 SPRY2 PIK3CD MAP2K5 PRKCZ TSC2 TSC1 ARAF PLCG2 PLCG1 MSH6 PIK3CA ERRFI1 PIK3R2 PIK3R1 CDK6 MDM4 FGFR1 PIK3C2G FOXO3A FOXO4 PIK3C2A NF1 MDM2 PIK3C2B CCNE1 ATM CBL CDKN1A PTEN BRCA1 BRCA2 HRAS GRB2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260211%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A1 SLC6A19 SLC6A20 SLC36A2 CLTRN SLC3A2 SLC7A7 SLC1A1 SLC7A9 JOUBERT SYNDROME%WIKIPATHWAYS_20260211%WP4656%HOMO SAPIENS Joubert syndrome PCM1 MRE11A OFD1 SHH RAD50 PDE6D PDE6A FLNA PDE6G INVS NPHP3 ZNF423 RHEB DVL1 SUFU RAB8A DVL3 CEP164 BBS9 BBS7 BBS5 CEP290 ATF4 BBS4 MYO6 KAT5 RP2 TMEM216 CEP104 ARL3 ARHA ARL13B TMEM67 INPP5E MTOR BBS2 NEK8 BBS1 CETN2 CCP110 AHI-1 PARP1 ARR3 TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP41 CEP97 CC2D2A ARMC9 ATM RPGRIP1L TMEM138 ARL2 NPHP1 PCNT PIBF1 RAB3IP CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 B9D1 B9D2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 ASL OTC NAGS GLS2 ASS1 ARG1 SLC25A13 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GALT1 B4GALNT1 B4GALT4 B3GNT5 ST3GAL5 A3GALT2 GBA2 UGT8 UGCG NEU3 NEU4 A4GALT GLA B4GALT5 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260211%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 GSK3B PDE4A TFAM PDE4B GUCY1B1 PARK2 HEL-S-162eP PDE4D NRF1 AKT3 PRKG1 PPARGC1A NOS2 PDE5A ZNF746 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2431%HOMO SAPIENS Spinal cord injury TLR4 MMP9 CXCL2 MBP CCR2 BDNF OMG GFAP PLA2G2A FKBP1A CCL2 CDKN1B C1QB SLIT2 EPHA4 PLA2G5 PLA2G6 TNLG7A IFNG RB1 NTN1 APEX1 CDC2 MIF CCND1 CCNG1 RGMA TGFB1 FCGR2A IL2 PLXNA2 IL4 CXCL8 GADD45A SELP EFNB2 NOX4 AIF1 AQP1 LTB PPP3CA RAC1 EGR1 ANXA1 MMP12 ZFP36 IL1A SEMA6A PDYN BCAN KLK8 EGFR BTG2 HEL113 NCAN AQP4 PRB1 PTGS2 PRB2 TACR1 VCAN TNFSF13 GAP43 CD47 ACAN SLIT1 SLIT3 LILRB3 GRIN1 CDK4 MYC CDK2 MAPK1 TNF MAPK3 CSPG4 GJA1 RTN4 PRKCA IL1R1 COL2A1 GDNF E2F5 RTN4R LEP NGFR CASP3 ARG1 COL4A1 ROCK2 LTB4R IL6 ARHA NOS2 SOX9 CDC42 FOXO3A ROS1 RHOB XYLT1 FOS IL1B CHST11 CXCL1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260211%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PPP2R3A PPP2R2C PPP2R2B PYGB PHKG2 PYGM AGL PHKB PHKA1 PHKA2 HK2 CALM1 PPP2R1B PPP2R1A GYS2 GYS1 PPP2R2A PPP2R5E GYG1 GSK3A PPP2R5B PPP2R3B PPP2R5A PPP2R5D PPP2R5C PTPA HK3 PYGL PPP2CA ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260211%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 COA3 AS3MT UQCRFS1 HEL-S-44 SDHA HEL-S-21 ND1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS1 PTGS2 EPHX2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260211%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A ITGB1 PAK1 CTNND2 ARHGEF7 GRIN1 RAP1A DLG4 HCN1 SPAAR ARHGAP44 SHARPIN LZTS3 ADGRL1 CDC42 SPTAN1 GRIA2 PS1TP5BP1 SHANK3 MAP3K7 GRIN2B SYNGAP1 DLGAP1 HRAS BAIAP2 HOMER1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260211%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TOMM70 IRF7 AGTR2 REN TRAF3 TRAF6 TBK1 TMPRSS2 NFKB1 CTSL MAVS RIGI ACE2 PHB2 NDUFB9 ACAD9 AGTR1 TLR7 NDUFAF1 IKBKE ECSIT TICAM1 NFKB2 CGAS NLRX1 MITA IFIH1 IRF3 TLR3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260211%WP4630%HOMO SAPIENS Measles virus infection TLR4 IRF7 CCND2 STAT2 TYK2 NFKBIA NFKBIB IKBKE CDKN1B OAS1 OAS2 CLEC4M BBC3 OAS3 IRF9 CCND3 IFNA6 IL12B MAP3K7 IL12A CCNE2 PIK3R3 STAT5B JAK3 CCND1 IL2RA IL2RB CD46 MAPK10 MAPK9 IL2RG MAPK8 CD3G CD3E STAT3 CD3D EIF3S3 BAX FCGR2B CSNK2A1 CSNK2A3 CSNK2A2 IL2 ADAR CASP8 CSNK2B PIK3R2 PIK3R1 HEL-S-103 FADD HEL-S-72p CCNE1 EIF2AK2 TRADD IKBKB JAK1 HSPA2 IFIH1 IRF3 IL1A IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 BAK1 RELA STAT1 IFNA21 TRAF3 IF1AA9 FAS CDK4 TNFAIP3 IFNA8 CDK2 MX1 LNIR CD209 BCL2L1 BCL2 RCHY1 RAB9A RAB9B TNFSF6 IFNA7 NFKB2 EIF2S1 CYCS IRAK1 PIK3CD IRAK4 CASP9 MYD88 TP73 CASP3 CHUK APAF1 TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD TLR9 TLR7 CDK6 HEL70 FOS IFNB1 IL1B EIF2AK1 EIF2AK4 IFNA1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260211%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB SLC16A7 SLC1A2 SLC4A4 SLC16A3 HEL-S-133P NUDT14 CA4 HEL-76 SLC2A3 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260211%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAP2K5 YAP1 AMOT PIK3CA NFKB1 MAP2K3 MAP2K4 MAPK1 ARHA RAC1 MAP2K6 MAPK3 MAP2K1 MTOR MAP2K2 TRIO MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260211%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYLK HEL114 LPP ITGB3 MFAP5 PLCG1 JUN ITGAV PXN TJP1 CREB1 MAPK1 MAPK3 MYL2 PRKCQ ACTN1 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP690%HOMO SAPIENS Polyol pathway KHK SORD ALDOB AKR1B1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2571%HOMO SAPIENS Polycystic kidney disease pathway SLC12A2 CFTR ADCY6 FLT1 NRAS BRAF IGF1 WNT7B IGF1R PDE1A WNT7A SRC KDR CTNNB1 MYC ERBB2 PRKAA2 TNF KRAS MAPK3 MAP2K2 WNT5B PRKAG1 PRKAG2 EGF PRKAG3 PRKAA1 PRKACG PRKAB2 RHEB PRKAB1 GNA11 DVL1 DVL2 DVL3 WNT1 KCNN4 WNT3 WNT4 WNT3A STK11 CCND1 VEGFB GSK3B WNT2B TSC2 GNAI1 TSC1 FZD10 PLCG2 WNT16 GNAI3 JUN PKD1 SFRP4 GNAS MTOR SSTR2 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT9B FZD5 RPS6KA1 FZD7 WNT9A FZD9 WNT8A FZD8 FOS WNT8B IKBKB HRAS EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX12 LTC4S ALOX5 ALOX15B ALOX15 KPG_011 HEL-S-298 EHHADH HPGD FPR2 CYP4A22 LTB4R NR1C2 NR1C1 TRPA1 CYP4F2 CYP4A11 TRPV1 PTGR1 CYP4F12 ACOX1 ACOX3 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH3 NOTCH1 MAML3 JAG2 PSEN2 ADAM10 CHUK DLK2 LEF1 MFAP1 PSEN1 MFAP2 HES1 DNER DLL3 DLL4 RRAS MAML2 MAML1 RBPJ NOTCH2 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 EBI3 GPR183 CRP TNFSF13 FOXO1 ISG15 IFITM1 MFGE8 CCL19 PTPRC TNF PAX5 ZEB2 CCL21 CXCR4 CD40 CD80 CD82 CD79A BACH2 IFIT2 C4A BLNK IRF4 CD19 CCR7 FCRL5 IRF8 TNLG7A IL12A CXCR5 CD1D SLAMF7 HEL-S-62p SH2D1A CD40LG IFNG CR2 CR1 MS4A1 CD22 IL-21 CXCL12 BCL6 TBX21 IFNAR2 IL10 IL2 IL4 IL6 BCR SYK TLR7 PDCD1 ICOS ICOSLG PRDM1 SELL CD69 HEL-S-72p XBP1 TMSB10 ITGAX MAF CXCL13 BTLA CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260211%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGA4 SELP ITGB1 KNG1 SELPLG HEL-S-62p IL6 CXCL8 C6 C7 TNF VCAM1 IL1A BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders UMPS RRM2B DPYS DHODH NT5C3A HEL74 TYMP HEL-S-29 RRM1 RRM2 TYMS DPYD GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR1 GABBR2 CASR GRM2 GPRC5A GRM4 GPRC5D GRM8 GPRC5C GRM3 GRM6 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260211%WP545%HOMO SAPIENS Complement activation C1R MASP2 MASP1 CFD C1QB C1QA C4B_2 C2 C4A C8A CFP HEL-S-62p C6 C7 C8G C9 CD55 C1QC ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP1541%HOMO SAPIENS Energy metabolism GSK3B MEF2C MEF2B MEF2D EP300 CAMK2G FOXO1 NR1C1 RXRA PRKAA2 ATF2 MAPK14 PRKAG1 PRKAG2 PPP3R1 PPP3R2 PRKAG3 PPARGC1B TFAM PRKAA1 PPARG FOXO3A UCP3 HDAC1 UCP2 SIRT1 SIRT3 PRKAB2 GABPA PRMT1 PRKAB1 NRF1 NR1C2 CREB1 PPP3CA PPARGC1A PPP3CC TFB1M TFB2M NCOA1 PPRC1 ESRRA MED1 MYBBP1A CAMK4 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes KCNJ2 HCN2 TMSB4X ERG GJA1 HAND2 IGF1 HCN4 KCNE1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling ANGPT2 BIRC5 HIF1AN BNIP3L ANGPT1 PTGS2 BAK1 BAX EPO VEGFA PFKL HEL-S-68p BCL2A1 HEL-S-30 NOS2 BNIP3 TGFA BCL2L1 PDHA1 IGFBP1 SLC2A3 EDN1 IGFBP2 HIF1A EGLN1 HEL-S-133P PMAIP1 MCL1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260211%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA NTRK2 AKT3 SORT1 KIDINS220 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260211%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 TDO2 NMNAT1 HEL-S-90n HAAO KMO KYNU AFMID T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260211%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling GSK3B CALM1 CD8B1 DYRK2 CD8A PLCG1 CSNK1A1 ZAP70 GSK3A NFKB1 IL2 PRKCA PTEN PPP3CA ITK FYN NFATC2 NFKBIA LCK CTLA4 DYRK1A PTPN6 PDCD1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260211%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO3A1 SLC16A2 SLCO4A1 SLCO1A2 SLC16A10 SLCO1C1 SLC7A5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP405%HOMO SAPIENS Eukaryotic transcription initiation TAF5 GTF2B GTF2H2C_2 TAF9 CCNH GTF2E1 GTF2E2 GTF2H2 GTF2F2 POLR2B GTF2H3 POLR2F POLR2G POLR2H ERCC2 POLR2I POLR2J MNAT1 POLR2K TAF13 POLR3B POLR3D TAF7 TAF6 POLR3H TBP POLR3K POLR1A POLR1D HEL-S-28 TAF12 CDK7 POLR2C POLR2A POLR3E ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway SERPINB2 EGFR POLK TGFB1 EP300 MYOF BAX JUN SLC7A5 SRC UGT1A4 IL2 AHRR UGT1A7 JUND TNF CAP2 PTGES3 MGST1 NFE2L2 CDKN1B CES3 UGT1A3 NQO1 CYP1A2 CYP1B1 CDC37 UGT1A1 UGT1A9 IGFBP1 CYP1A1 IL12B HES1 IL12A JUNB AIP ALDH3A1 IFNG IL1B AHR IL17B NCOA1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 ACADS ACSL3 ACADM PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260211%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 BATF CD8B1 CD3G STAT3 CD3E CD3D CD8A JUN ZAP70 NFATC1 HLA-DRB1 NFKB1 HLA-A PDCD1LG2 IFNG NFATC3 NFATC2 PTPN11 NFATC4 LCK PDCD1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP23%HOMO SAPIENS B cell receptor signaling HCLS1 CAMK2A RELA GAB2 BRAF VAV1 VAV2 FOXO1 SHC1 PDPK1 MYC CARD11 BCL10 MAPK1 PTPRC FYN MAP2K6 NFATC3 NFATC2 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 RAF1 CD79B CD79A BLNK CD19 PRKCB MAP3K7 STM7 GTF2I CR2 PIP5K1A REL PIP5K1C BLK BTK CD22 LCK GSK3B MAP4K1 MAPK9 MAPK8 CHUK BCL6 PLCG2 CRK IKBKG PLCG1 JUN NFKB1 MAX RASGRP3 CRKL INPP5D LYN SYK PIK3R2 PIK3R1 CDC42 RAPGEF1 CD81 LAT2 DAPP1 PTPN18 TIEG2 PIK3AP1 CBL RPS6KA1 NCK1 GSK3A IKBKB CREB1 MAPK4 RAC1 HRAS GRB2 SOS1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260211%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ITPR2 CYP21A2 AGTR2 PLCB2 STAR CALML6 REN CALML3 CALML4 CAMK1 CAMK2G CMA1 ATF1 ATF2 CYP11B2 AGTR1 HSD3B2 CYP11A1 CALM1 CREB3L3 CREB3L4 HSD3B1 CTSG CAMK1D CAMK1G CREB3L2 CREB3 CREB1 CREB5 CAMK2D ATF6B CAMK4 ATF4 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF RAF1 TSC2 STAT3 TSC1 NRAS EREG BTC RHEB TYK2 PTEN AKT3 KRAS SOS2 JAK1 HRAS RPTOR JAK3 MTOR GRB2 TGFA SOS1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260211%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKB1 RAF1 RRAS IKBKB CHUK MAPK1 MAP3K14 MAP2K6 TRAF6 MAP3K1 NFKBIA IKBKG SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP3944%HOMO SAPIENS Serotonin and anxiety related events FOS ARC PLCD4 NLGN1 5HT1A CRHR1 PLEK PPP3CA CRH HTR2A PRKCB SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TOMM70 NLRP3 TERF2IP REN TRAF3 TRAF6 SIRT6 RPS6KA1 ECSIT NDUFAF2 NFKB1 IL18 IL6 TERF2 MAVS TNF NLRX1 MITA ACE2 ACAD9 NDUFAF1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4E IFRD1 ADAM10 NR4A3 VEGFA HEL-S-52 IL18 IL1R1 IFNG CYR61 DUSP14 HBEGF JUND EIF4EBP1 GDF8 ANKRD1 MYOG ATF3 IL1A OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP34%HOMO SAPIENS Ovarian infertility CCND2 TSC2 TSC1 PRLR CEBPB RAD51 CDK4 SYNE2 NR1i1 NR5A1 TBP MTOR NR3A2 NCOR1 PGR CDKN1B FSHR ATM FMR1 GJA4 LHCGR FIGLA DAZL GDF9 DMC1 CREB1 ZP3 ZP2 EGR1 SMPD1 PTGER2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260211%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets FLT3LG ID2 STAT3 RUNX2 SPI1 IKZF1 IRF4 IRF8 TCF4 CSF1 BATF3 CSF2 TPO TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260211%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDKN2A ACTL6B EZH2 ACTL6A CDK4 PTCH1 EED SMARCD1 CDK6 SMARCC1 SMARCA4 SMO SMARCD2 ARID1A SMARCC2 SMARCD3 SUZ12 GLI3 ARID1B RB1 H3F3B GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260211%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260211%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAP3K7 MAPK8 IKBKB CHUK RELA CD40 IKBKG EPHB2 ERBIN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260211%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CDKL5 MEF2C FRS3 CAMK2A DOK5 KCNN2 DOCK3 KCNA3 NCAM1 ARHG SIRPA SH2B1 RANBP9 MARCKS VAV2 BDNF SRC SHC1 KSR1 PDPK1 EIF4EBP1 PRKAA2 FYN SHC4 YBX1 SHC2 PTPN11 SHC3 NFATC4 NFKBIA EIF4E GRIA2 RPS6 RPS6KA5 GRIA3 RPS6KB1 SQSTM1 ACACB STAT5B PTK2B PTPRF MAPK10 MAPK9 TSC2 MAPK8 EIF2S2 STAT3 CRTC1 MAP3K2 CSNK2A1 RAP1A GRIP1 PIK3R2 PIK3R1 RASGRF1 CYFIP1 GRIN2B IKBKB RAC1 HRAS IGF2BP1 RELA STAT1 CDH2 MAP3K1 CAMK1 GRIN1 CTNNB1 CDK5R1 RPS6KA3 IRS1 MAPK1 MAPK3 MAP2K1 MAPK14 MAP2K2 ADAM17 RAF1 PRKAA1 NCF1 NTRK1 NTF3 NTRK3 PPP2CA TIAM1 EIF2S1 CDK5 GSK3B HEL-S-15 MAP2K5 NGFR EEF2 CASP3 CHUK TRAF6 PLCG1 IKBKG JUN NFKB1 MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 BAD MTOR APC CDC42 NCF2 FOXO3A GABRB3 RPS6KA1 NCK2 NCK1 VAV3 NGF CREB1 FRS2 CNR1 GRB2 SYN1 CAMK4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260211%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2L1 BCL2 FADD CASP9 CASP3 BBC3 APAF1 BAX TNFSF6 TNF MAPK12 CASP8 MAPK13 BAD MAPK11 MAPK14 MCL1 BCL2L11 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260211%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP2C8 PTGS2 CYP2C9 CYP1A2 ALOX15 EPHX3 ALOX12B PTGS1 CYP2C19 CYP3A4 CYP4A11 GPX4 ALOXE3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260211%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 MCL1 ZAP70 TAR SYNDROME%WIKIPATHWAYS_20260211%WP5362%HOMO SAPIENS TAR syndrome SLC34A3 ITGB1 EGFR HDAC2 CFTR ANKRD35 EIF4A3 GPR89B AKAP10 SLK SUMO2 MAGOH FURIN NUDT17 HEL-S-76p HLA-B HLA-F HLA-G HLA-E RBCK1 MET SLC22A4 PEX11B CLCN3 BCL2L13 TNFRSF14 FARP2 FLT3 NHERF1 UBE2I POLR3GL CD160 PYM1 CXCR4 PDZK1IP1 POLR3C POLR3F POLR3G SIRT1 MITD1 DDIT4 LAMTOR1 IFNG LCK HFE2 HAMP STAT3 CD3D TXN CCAR2 NFKB1 HLA-A HLA-C PEX19 ZFHX3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR17 P2RY11 HTR1F ADORA2B OR2F1 F2RL2 OR2A4 GPR18 ACKR3 HRH3 ADRA1B ADRA1A PTGFR NPFFR2 RRH GPR174 PTGDR2 GPR173 GPR171 CMKLR2 CMKLR1 GPR37L1 FPRL2 TRHR TBXA2R PTGDR OR1I1 MC2R PTGIR GALR3 GALR2 GALR1 NPBWR2 OR6B1 CCR10 NTSR2 CCR1 XCR1 OR2J3 OR2J2 OR2J1 RGL4 F2RL1 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR OPN1LW CCR8 CCR4 GPR39 OR5F1 GPR34 GPR31 NPFFR1 AVPR1A OR5V1 OPN1MW OR3A2 OPRD1 OR10H1 OR10H3 GPR45 GPR68 CCR3 OR10H2 GPR42 OR2AG1 CHML OPRK1 EDNRB P2RY10 P2RY14 NPY1R GPR52 GPR50 GPR4 GPR15 GPR3 GPR6 MC5R F2RL3 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 MCHR1 OR2S2 HCAR3 OR1Q1 HRH1 HCAR1 HRH2 OR2B3 DRD5 OR2B2 CCR6 HTR1E HTR1D HTR1B NMUR2 NMUR1 OR7A10 OR14J1 MLNR HTR2B PRLHR OR8D2 OR7A17 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 CX3CR1 OR1E2 NPY4R BDKRB2 OR8B8 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OPN1SW ACKR4 FFAR1 ACKR2 OR11A1 KPG_010 GPR83 LPAR4 KPG_011 AVPR2 GPER CCRL2 CHRM4 CHRM5 PTGER4 PTGER2 AGTR2 CCR2 GPR75 AVPR1B NMBR CXCR4 C3AR1 PTGER1 PTGER3 GHSR RHO C5AR2 NPY2R FPR1 HTR7 BDKRB1 GPR37 MTNR1A ADRB1 MTNR1B GPR161 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 P2RY1 CHRM1 ADRA2C ADRA2B MGRA ADRA2A MC3R AGTR1 OXTR ADORA2A HTR5A 5HT1A CNR2 CCR7 CXCR5 HCRTR2 HCRTR1 MC4R CHRM2 CHRM3 OR1G1 ADRA1D GPR32 HTR2A FPR2 P2RY6 HTR4 P2RY4 GRPR HTR6 ADRB3 P2RY2 LTB4R EDNRA CCR5 OR1F1 F2R OR2H1 FFAR3 FFAR2 SSTR2 CCKBR FSHR OR3A3 OR10A5 OR3A1 OR1E1 LHCGR ADRB2 IL8RB CXCR1 CNR1 CXCR3 OR2B6 NTSR1 MC1R P2RY13 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK NFE2L2 MAPK8 SP1 MAFF MAP2K1 MAP2K2 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260211%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 PHF19 CD40 STAT4 ITGAV HLA-DRB1 MHC2TA SLC22A4 TRAF1 BLK CTLA4 IL2RA IL6ST CCR6 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260211%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2 COX1 MB HBB XDH NOS2 AOX1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDKN2A EGFR SMAD4 RELA TRAF3 MAPKAP1 NRAS VEGFA IGF1R CTNNB1 PDPK1 CDK4 AKT3 ERBB2 PRKAA2 EIF4EBP1 FKBP1A KRAS RPTOR IRF6 MLST8 TP63 NOTCH2 NOTCH1 EIF4E RPS6KB2 NFE2L2 FGFR2 SESN2 PRKAA1 CSMD3 RPS6 DDIT4 SESN1 RHEB TERT NFKB2 RB1 REL STK11 CCND1 KEAP1 AJUBA TSC2 TSC1 BIRC2 PIK3CA NFKB1 MAML1 CASP8 FAT1 MTOR PIK3R2 PIK3R1 NUMB PIK3R5 CDK6 FADD FGFR1 CDKN1A PTEN RICTOR HRAS TGFBR2 FGFR3 SERINE METABOLISM%WIKIPATHWAYS_20260211%WP4688%HOMO SAPIENS Serine metabolism SHMT1 HEL-S-51e PHGDH TYMS SRR PSAT1 DHFR PSPH CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260211%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 RELA IFNA21 CASP10 IF1AA9 ISG15 IFNA8 CCL5 CCL4 NFKBIA IL33 NFKBIB POLR3GL IKBKE POLR3C POLR3F ZBP1 POLR3G AIM2 ATG12 POLR2L TREX1 IFNA6 POLR3A RIPK3 IFNA7 RIPK1 CHUK TBK1 IKBKG TRIM25 POLR2F RNF125 POLR2H NFKB1 CYLD ATG5 ADAR POLR2K IL6 POLR3B MAVS POLR3D CASP8 RIGI IFNA2 POLR3H POLR3K POLR1C POLR1D FADD PYCARD CCL4L2 TRADD IL18 IFNB1 IKBKB IL1B CGAS MITA NLRX1 POLR3E IFNA1 IRF3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260211%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 CHD3 HBB GATAD2B MTA2 NR2C2 HDAC1 tal-1 HBG2 LDB1 LMO2 HBD BCL11A HBG1 HBE1 GATA1 KDM1A ZFPM1 KLF1 ZBTB7A PPARGC1A MYB PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260211%WP4022%HOMO SAPIENS Pyrimidine metabolism CDA DPYS TYMP TK1 POLE4 RRM1 RRM2 UCK2 UCK1 UMPS POLR3GL POLR3C POLR3F POLR3G POLR2L TYMS ENPP1 POLR3A POLD3 POLD4 POLE RRM2B ZNRD1 HEL74 ENTPD3 NME2 NME3 CTPS2 CTPS1 POLE2 NME4 POLR2A DCTD POLE3 NME6 NME7 CMPK1 CMPK2 POLR1F UPRT DCTPP1 PRIM2 POLA2 DTYMK DHODH POLR2D NT5M POLR2J3 DUT PNPT1 POLR2J2 POLA1 CAD POLR2B ENTPD1 POLR2G POLR2H POLR2I POLR2J POLR2K POLR3B POLR3D POLR3H ENPP3 POLR3K POLR1A POLR1C POLR1D PRIM1 POLR2C POLD2 POLR3E DPYD GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260211%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG SLC5A1 PCSK1 SLC2A2 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260211%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 KCNQ3 PTGS1 5HT1A FAAH TRPA1 PTGS2 CACNA1H TRPV1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260211%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 ETS2 BIRC5 EGF CD81 EGFR STAT3 IGF1 CD63 KDR PTEN IL6 GATA4 HEL-S-102 SPP1 HEL-S-44 ADIPOGENESIS%WIKIPATHWAYS_20260211%WP236%HOMO SAPIENS Adipogenesis MEF2C MIXL1 MEF2B KLF6 STAT2 CYP26A1 MEF2D NR2F1 PRLR CEBPA CEBPB EGR2 KLF5 CEBPD LIF GATA3 GATA2 CYP26B1 KLF15 SOCS3 SOCS1 TWIST1 GATA4 SLC2A4 RARA LIPE NR1C2 TRIB3 HIF1A RB1 PTGIS STAT5B GADD45B PCK2 AHR MIF HMGA1 RORA CFD RXRG WWTR1 TGFB1 STAT3 E2F4 SFRP4 DDIT3 SCD GADD45A GH1 FZD1 WNT10B PPARGC1A NCOA1 LPIN1 LPIN2 LPIN3 STAT1 ID3 FOXC2 IGF1 BMP4 FOXO1 INS FAS CTNNB1 NR1C1 IRS1 RXRA IRS4 TNF WNT5B IL6ST NCOR1 MBNL1 HNF1A BMP1 LPL NR3C1 CELF1 ZMPSTE24 LMNA CISD1 DVL1 RBL2 RBL1 WNT1 NR1H3 BMP2 OSM LEP RETN CNTFR GTF3A BSCL2 ADFP NDN BMP3 PLIN1 FRZB IL6 SPOCK1 SP1 UCP1 GDF10 KLF7 PCK1 NCOR2 NAMPT PPARG PNPLA3 CDKN1A CREB1 ASIP SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP247%HOMO SAPIENS Small ligand GPCRs LPAR1 MTNR1A PTGER1 PTGER3 GPR50 MTNR1B CNR2 S1PR3 PTGFR TBXA2R PTGDR PTGIR S1PR2 S1PR4 PTGER4 CNR1 S1PR1 PTGER2 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP58%HOMO SAPIENS Monoamine GPCRs HTR1D HTR1B HTR1F CHRM2 CHRM3 HTR2B ADRA1D HTR2A HTR4 HTR6 ADRB3 CHRM1 HTR7 ADRA2C ADRA2B ADRA2A ADRB1 ADRA1B HTR5A ADRA1A 5HT1A CHRM4 CHRM5 ADRB2 DRD1 DRD2 DRD3 DRD4 HRH1 HRH2 DRD5 HTR1E ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP554%HOMO SAPIENS ACE inhibitor pathway KNG1 AGTR2 TGFB1 REN CTSG CMA1 BDKRB2 ATP6AP2 NR3C2 MGRA BDKRB1 ACE2 CYP11B2 AGTR1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 SELE ITGB1 ITGB7 SELPLG ITGA2 MADCAM1 VCAM1 SLEEP REGULATION%WIKIPATHWAYS_20260211%WP3591%HOMO SAPIENS Sleep regulation GHRH BTBD9 GHRL STAR HTR2A NPY2R ADA SLC29A1 IL6 HEL-S-2 CHRNB2 UTS2R MRGPRX2 OXTR ADORA2A MTNR1B NLGN1 OXT UTS2 TH NPS NPAS2 FOS DRD1 PTGDR IL18 DRD2 DRD3 DLAT CRH CACNA1I HCRTR2 HCRTR1 PER3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP3995%HOMO SAPIENS Prion disease pathway MEF2C CASP3 NCAM1 CTCF EP300 STAT3 CHD2 SMC3 HEL-S-89n NFKB1 PRNP RXRA MAPK1 FYN MAPK3 TBP HEL-S-269 RFX5 HEL-S-125m BCL2 PAX5 BATF RAD21 FGFR1 SPI1 POU2F2 IRF4 BCL11A CREB1 CASP12 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260211%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation TACI TLR4 SMCR8 IFT46 C9orf72 IFT70B WDR26 GPS1 MIEF2 RAB10 RASD1 RANBP9 RMND5A FNIP1 FNIP2 NR1H2 MYO16 MKLN1 GID4 MYO15A DRG2 RPTOR BCL2L11 MLST8 PRKAG2 PRKAB1 IRF8 HEL-S-133P G6PC1 CDC2 MYH2 WWTR1 APP PPP1R14A STAT3 BCL6 BAX YAP1 PARK2 IFT172 BLM IFT74 CLTB GRIP1 ULK1 PRDM1 IFT81 IFT27 IFT25 MED9 RAI1 GPR85 PTEN CLEC16A CARM1 RELA TNFSF13 MYC TNF FOXA1 CRY2 CRY1 PRKAA1 FOXA2 ATG101 TRAF3IP1 RAB8A FLCN IFT52 NR1H3 CFL2 PRKCI PARD3 IFT57 PER1 FLII IFT80 MYD88 RB1CC1 NT5M ARG2 TFEB BIRC2 ROCK1 JUN PARD6B NFKB1 LIMK1 MAP3K14 ARHA MTOR FERD3L HES6 PCK1 ALKBH5 CLTC MAEA DENR CLTA MIGA1 ARMC8 RNF41 TOM1L2 FHOD1 RRAGA PEMT LLGL1 DRC5 SHMT1 CLUAP1 DRC7 DRC8 COPS7A PLD6 RAB39B COPS4 IFT20 COPS6 IFT22 COPS5 DRC1 COPS8 GDI2 CREB1 WDR41 IL1B IFT56 ATPAF2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5028%HOMO SAPIENS Glycine metabolism including IMDs SHMT1 HEL-S-302 LIPT2 LIPT1 GLDC AMT DLD HSCB LIAS GCSH NFU1 BOLA3 ISCU PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP4172%HOMO SAPIENS PI3K Akt signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PKN2 KDR PDGFRA PDPK1 HGF PRKAA2 SOS2 MET RPTOR TGFA BCL2L11 MLST8 PDGFC FLT3 EIF4E EIF4B EGF RPS6KB2 FGFR2 GYS2 GYS1 RPS6 RPS6KB1 RHEB PIK3R3 G6PC1 JAK3 STK11 MCL1 CCND1 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 IL4 SGK1 PIK3R2 SYK PIK3R1 IL3 IL3RA GH1 MDM2 PKN3 PKN1 PTEN BRCA1 IKBKB RAC1 JAK1 HRAS IFNA13 IFNA14 EGFR NTF4 IFNA16 IFNA17 FLT3LG IFNA10 RELA IFNA21 FGFR4 IF1AA9 NRAS VEGFA FGF10 IFNA8 IL7 CSF1 IRS1 MAP2K1 MAP2K2 HEL-S-125m BCL2L1 TCL1B TCL1A PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 CDC37 TNFSF6 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 GNGT2 RBL2 FGF8A OSMR COL2A1 KIT PHLPP2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD NGFR CASP9 KITLG GHB3 CSF3 CHUK CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 CSF1R NTRK2 EFNA5 EFNA4 CHAD FGF20 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 EFNA3 PCK1 FGF14 EFNA2 PIK3R5 CDK6 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 G6PC2 ITGB4 FLT4 LAMC2 FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 IFNA1 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C TLR4 ANGPT4 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 PRL LAMB2 PPP2R3A EPOR PPP2R2C PRLR PPP2R2B PPP2R2D BDNF EIF4EBP1 GHB2 GHR CSH2 G6PC3 COL6A6 COL6A5 CDKN1B ITGB3 IGF2 ITGA2B CCND3 IFNA6 CD19 LAMC1 IBSP IL6R CCNE2 ITGA1 COL6A1 PCK2 ITGA2 COMP COL4A3 COL9A1 COL9A3 COL9A2 COL4A5 COL1A1 LAMA5 LAMB4 SGK2 THBS1 VTN SPP1 LAMB1 CCNE1 FGF23 TNC FLT1 INSR PDGFA IGF1 IGF1R INS CHRM1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 ATF2 COL1A2 MYB PDGFD BCL2 PRKAA1 PHLPP1 PPP2R2A PPP2R3B PRKCA NTRK1 NTF3 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 NFKB1 GNG13 IL6 GNB2 GNB1 IFNA2 GNB4 F2R GNB3 GNB5 GNGT1 PIK3AP1 CREB3L2 CREB3 CREB1 ATF6B HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260211%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis SYT2 HNRNPL CALM1 CAMK2A BCL2 CCND2 PRL NCAM1 RPS6KA5 RPS6KA1 NRXN1 BDNF NRXN3 NRXN2 PRKCA DRD1 NGF CAMKK1 CREB1 CAMKK2 MAPK1 PPARGC1A MAPK14 CAMK4 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260211%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 RYR1 CCK RYR2 PLCB1 CCKBR DAGLA GNAI1 RYR3 CNR1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260211%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PANK2 RB1CC1 TSC2 TSC1 FTL WIPI1 WIPI2 ATG5 ATG14 CP RPTOR MTOR ULK1 PIK3R4 DEPTOR MLST8 WDR45 ACACA DCAF17 C19orf12 ATG3 COASY FA2H PRKAA1 ATG12 RHEB ATG16L1 PLA2G6 AKT1S1 ATG101 ATG2A MAP1LC3A SPTLC1 ATG10 STK11 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260211%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P REN CTSG CMA1 PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP24%HOMO SAPIENS Peptide GPCRs AGTR2 TACR1 CCR2 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 CX3CR1 NPY4R BDKRB2 MC3R AGTR1 OXTR AVPR1B NMBR CXCR4 ATP8A1 TACR2 TACR3 CXCR6 TAC4 CCR7 CXCR5 FPRL2 TRHR C3AR1 MC2R GALR3 GALR2 GALR1 HCRTR2 CCR10 HCRTR1 NTSR2 CCR1 GHSR MC4R BRS3 C5AR1 NPY2R CCKAR FPR2 FPR1 GRPR CCR8 CCR4 EDNRA AVPR2 AVPR1A GNRHR CCR5 OPRD1 BDKRB1 TSHR CCR3 OPRK1 EDNRB NPY1R SSTR2 CCKBR FSHR MC5R LHCGR IL8RB FY CXCR1 CXCR3 NTSR1 MC1R CCR6 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome CBX3 RNF8 NIPBL H2AX MDC1 ATM RNF168 ATR METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260211%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer GLS PYCR2 PSAT1 HEL-S-162eP PFKL PSPH ACLY ENO1 HEL-S-68p PGAM1 HEL-S-30 PAICS PDHA1 MDH2 GOT2 FASN SLC16A3 GLUD1 HEL-S-51e ALDOB TIGAR SDHB ACO2 FH RPIA SUCLG2 HEL-S-133P HK3 HEL107 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 ALOX15 EPHX2 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260211%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 SMAD4 CHUK RELA NR3C1 MAP3K1 MED14 IKBKG NFATC1 NFKB1 IL6 MAP2K3 IKBKB RXRA PPP3CA NR1i1 TNF MAP2K6 MAPK14 NFKBIA NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260211%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA AKT3 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP304%HOMO SAPIENS Kit receptor signaling MAPK8 KITLG EP300 STAT1 STAT3 GAB2 CRK PLCG1 VAV1 GRB7 SRC SHC1 SH2B2 RPS6KA3 SOCS1 MAPK1 CRKL FYN MAPK3 INPP5D BAD PTPN11 MAP2K1 MAPK14 LYN MAP2K2 TEC PIK3R2 PTPN6 PIK3R1 RAF1 FOXO3A RPS6 CBL GRB10 RPS6KA1 SOCS6 RPS6KB1 MATK PRKCB PRKCA DOK1 KIT STAT5B HRAS BTK GRB2 SOS1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260211%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2 UGT1A4 NAT2 CYP1A2 SULT1A1 UGT1A9 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260211%WP3527%HOMO SAPIENS Pre implantation embryo KLF4 ZFP36L2 SOX8 MXD1 ZFP42 POU5F1 GATA3 GATA2 SIX3 DPPA3 SOX2 TFAP2B IRX5 SOX11 ELAVL1 IRF4 NANOGNB FOXD1 DNMT3L KHSRP MYBL1 ZAR1 ARGFX TCF7L1 DLX2 PADI6 BARX2 LEUTX TPRX1 E2F5 TBX3 DPRX CDX2 ZSCAN4 MACROH2A2 HMGA1 HNRNPAB MTA3 FOXQ1 AQP3 NR3C2 DDIT3 PBX1 SMARCA4 AQP9 ATP1A1 NKX2-1 TEAD4 BATF3 EGR1 MOS FOSB ESRRA ZFP36 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260211%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 SCARB1 LDLR PLTP APOE LPL LIPC VLDLR APOA2 DNA REPLICATION%WIKIPATHWAYS_20260211%WP466%HOMO SAPIENS DNA replication RPA4 MCM5 MCM6 PRIM2 POLA2 CDC45 RFC2 POLA1 RFC3 RFC4 CDK2 RPA3 RPA1 PCNA MCM2 GMNN POLD3 RFC1 PRIM1 POLD4 UBC POLE ORC6 ORC3 POLE2 ORC2 POLD2 CDC6 MCM7 ORC1L MCM10 DBF4 CDT1 MCM3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260211%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways HDAC2 CYP46A1 MBP NR1H2 BDNF EIF4EBP1 PRKAA2 RPTOR DEPTOR BCL2L11 PRKAG1 MLST8 PRKAG2 EIF4E EGF PRKAG3 C1QA RPS6KA5 PRKAB2 RPS6KB1 RHEB PRKAB1 SREBF2 AKT1S1 HMGCS1 ABCG1 PIK3R3 ABCG4 PI3 MAPK10 HAP1 MAPK9 RAB3GAP1 TSC2 MAPK8 TSC1 BAX CASP8 PIK3R4 PIK3R2 PIK3R1 AHI-1 APOE PTEN IKBKB PPARGC1A SIN3A HRAS EGFR SLC12A2 HTT AKT3 MAP2K4 MAPK1 KIF5A MAPK3 MAP2K1 MAP2K2 MAP3K10 BCL2L1 BCL2 RAF1 PRKAA1 HDAC1 NEUROD1 ABCA1 HEL-S-29 REST PIK3CD CYP51A1 CASP3 DHCR7 HMGCR PIK3CA NFKB1 IL6 NTRK2 SP1 GABRG2 BAD BNIP3 MTOR PIK3R5 PIK3C2G PIK3C2A OPA1 PIK3C2B GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 CREB1 GABRA3 GABRG3 IL1B GABRG1 RICTOR SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260211%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2 PAPSS2 PAPSS1 SULT1B1 SULT2A1 SULT1A1 SULT1E1 SULT2B1 SULT1C3 SULT6B1 SULT1C2 SULT1C4 HEL-75 SULT1A4 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260211%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260211%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity MARK1 BAK1 CASP10 MBP FAS CX3CR1 CX3CL1 MFGE8 AXL FCN1 FCN2 C1QB C1QA ITGB3 COLEC11 DIABLO PROS1 TNFSF6 C4B_2 C2 C4BPA C4A C8A HEL-S-62p C3AR1 IFNG MBL2 CR2 CR1 PRKCI PARD3 CYCS C1QC SERPING1 MASP2 MASP1 CD46 CAP1 CFD CASP9 PRKCZ CASP3 TGFB1 PATJ FCN3 APAF1 CFH BAX C4BPB C5AR2 DLGAP5 ATP11A CFI ATP11C C5AR1 SCRIB PLSCR3 PLSCR4 TYRO3 PARD6B LLGL2 PARD6A CRB2 CFP COLEC12 CRB1 PALS1 COLEC10 VTN PARD6G CLU ATP10A C6 C7 DEDD C8G CASP8 C9 ATP8B3 CD59 ATP8B2 CD55 ATP8B1 C1R ITGAM ITGAV ITGAX PLSCR1 HTRA2 MERTK CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260211%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling TLR4 CAMK2A CYP21A2 STAR RELA BRAF CTNNB1 PRKAA2 MAPK1 JUND MAPK3 MAP3K5 TFAP2A MAP2K1 MAPK14 NFKBIA ERN1 BCL2 ACACA RAF1 GJA1 HSD3B1 GNAZ PRKCB GNA11 JUNB TCF4 PRKCA CACNA1H PRKCI PRKCQ GSK3B CASP9 MAPK9 CRHR1 MAPK8 CASP3 GNAI1 TGFB1 PLCG2 PLCG1 TRIM28 NFKB1 JUP IL2 SP1 CXCL8 GNB2 ARHA CRHBP GNB1 KRT1 GNAS IVL CRHR2 GNB3 GNAO1 HSD3B2 KRT14 GNB5 ECE1 CYP11A1 POMC PARP1 FOSL2 FOSL1 ARRB2 SULT2A1 FOS IL18 CREB1 CASP12 CRH FOSB SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP3947%HOMO SAPIENS Serotonin and anxiety POMC PLCD4 ADRA1A 5HT1A PLEK EEF2K HTR2A PRKCB FMR1 FOS ARC PPP3CA CRH TRPV1 IL1 SIGNALING%WIKIPATHWAYS_20260211%WP195%HOMO SAPIENS IL1 signaling IRAK1 IRAK2 UBE2V1 IRAK4 PRKCZ MAPK9 TAB3 MAPK8 MYD88 RELA CHUK TRAF6 MAP3K1 PLCG1 IKBKG MAP3K2 MAP3K7IP1 JUN NFKB1 MAP2K3 HEL-S-71 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 PIK3R2 PIK3R1 IRAK3 NFKBIB PELI1 HSPB2-C11orf52 ECSIT MAP3K7 SQSTM1 IL1R1 IKBKB IL1B REL MAPKAPK2 IL1A PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases AGXT2 DPYS DHODH TYMP NT5C3A RRM1 RRM2 TYMS CAD ABAT UMPS OTC RRM2B GLS2 HEL74 DPYD OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL1 FADS1 ELOVL5 SCD5 ELOVL6 FASN ELOVL3 FADS2 SCD ACSL1 ELOVL2 FACL4 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260211%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 CS PC SDHA HEL-S-26 OGDH ACLY FH DLD SUCLG2 DLAT HEL-S-32 HEL60 PCK1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36B IL36RN STAT1 IL36G IL1F10 GATA3 SOCS3 CSF1 SOCS1 MAPK1 BCL2L11 IL37 POLR2L ANAPC1 ZNRD1 IL1R1 IL23A POLR1F ARF6 PLCG2 POLR2F POLR2H IL2 POLR2K IL6 POLR1A POLR1C POLR1D CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1G FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 TTL IL1RL2 NT5DC4 IL1B CSF2 RAC1 IL1RN MERTK CXCL13 GRB2 IL36A IL1A HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260211%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling EGFR FLT1 RELA INSR FGFR4 BRAF PML CSNK1A1 FOXO1 IGF1R SRC KDR KSR1 SHC1 PDGFRA GAREM2 CTNNB1 MYC AKT3 MAPK1 SOS2 KRAS MET MAPK3 RPTOR MAP2K1 NFKBIA DEPTOR MAP2K2 MLST8 FLT3 ZBTB16 PYGO1 RAF1 BCL9 RARA FGFR2 RUNX1T1 LEF1 EPHA2 RHEB AKT1S1 NR1C2 IL6R NTRK1 TCF3 KIT WNT1 REL CCND1 GSK3B PIK3CD NGFR TSC2 RETN CHUK TSC1 STAT3 IKBKG AXIN2 JUN PIK3CA NFKB1 JUP CSF1R NTRK2 IL6 LRP5 LRP6 ULK2 MTOR APC TTI1 SALL4 FGFR1 FLT4 MDM2 FOS CDKN1A PTEN IKBKB HRAS GRB2 NFKBIE SOS1 FGFR3 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260211%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 MELANOMA%WIKIPATHWAYS_20260211%WP4685%HOMO SAPIENS Melanoma CDKN2A PAK1 BAK1 NRAS BRAF KDR CDK4 AKT3 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC2 PTPN11 MAP2K1 PDE5A MAP2K2 RAF1 HEL114 E2F2 DDB2 PIK3R3 RB1 KIT GADD45B GADD45G CCND1 PIK3CD POLK CALML6 ARAF EXOC7 BAX CALML3 CALML4 PIK3CA ARHA BAD GADD45A PIK3R2 PIK3R1 CALM1 CDK6 E2F3 RHOB NF1 MDM2 GRM3 PREX2 CDKN1A PTEN RAC1 HRAS GRB2 SOS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP5293%HOMO SAPIENS Acute myeloid leukemia RELA NRAS BRAF PML CEBPA MYC AKT3 EIF4EBP1 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 FLT3 ZBTB16 RAF1 RPS6KB2 RARA RUNX1T1 RUNX1 SPI1 LEF1 MPO RPS6KB1 NR1C2 CCNA2 PIK3R3 TCF7L2 TCF7L1 KIT STAT5B PER2 CCND1 PIK3CD CHUK STAT3 ARAF IKBKG PIK3CA NFKB1 JUP CSF1R BCL2A1 BAD MTOR PIK3R2 PIK3R1 IL3 PIM1 PIM2 ITGAM CEBPE FCGR1A IKBKB CSF2 HRAS GRB2 SOS1 CD14 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260211%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TEDC1 TEDC2 IFT46 FBF1 KATNB1 IFT70B TUBD1 KIF3B CEP76 MIB1 TUBE1 KIAA0753 CPLANE2 SASS6 CEP162 OFD1 CIBAR1 CEP44 CEP20 DYNC2I2 CEP19 DYNC2H1 DYNLT1 DYNLT2B TRAF3IP1 DYNC2LI1 IFT52 KIF3A TMEM107 BBS9 BBS7 IFT57 RABL2B BBS5 BBS4 IFT140 DNCL1 IFT80 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 IFT172 TMEM216 WDPCP IFT74 CEP104 CEP192 ARL6 ARL3 ARL13B TMEM67 INPP5E EVC2 BBS2 BBS1 SCLT1 IFT81 FUZ TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP97 IFT27 CC2D2A CLUAP1 ARMC9 IFT25 RPGRIP1L PIBF1 IFT20 CPLANE1 TMEM231 TMEM17 TTC23 C2CD3 B9D1 CBY1 IFT56 RAB23 EFCAB7 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 CCDC41 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3286%HOMO SAPIENS Copper homeostasis GSK3B ATP7B SLC31A1 ATP7A APP CASP3 COX17 MT2A SLC31A2 FOXO1 COX11 JUN COMMD1 MT4 MT3 PIK3CA ATOX1 MT1A MTF1 PRNP MT1F SP1 MT1G MT1B XAF1 STEAP1 STEAP2 MT1E HEL-S-44 CCS APC STEAP4 ADAM17 ADAM10 FOXO3A MDM2 STEAP3 PTEN ADAM9 CCND1 SLC11A2 BACE1 SCO1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260211%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence HMGA1 SLC2A4 MDH2 PARP1 GOT2 ELAVL1 NAMPT CCL27 PRKAA1 RELA SIRT1 SIRT3 IL6 IL1B SIRT5 HEL-S-32 NMNAT2 SIRT2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260211%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG1 HBA2 HBE1 GATA1 HBB HBZ tal-1 HBG2 LDB1 LMO2 HBD RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260211%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer MCM6 TTK CDC45 RRM1 RRM2 TOP2A DHFR WEE1 SUV39H1 HMGB1 CDK4 MYC CDK2 MAPK13 RPA3 SMC2 RPA1 NPAT HLTF PLK4 CCDC6 RAF1 CDKN1B RBBP7 HDAC1 CCND3 TYMS E2F2 PRMT2 POLD3 SMC1A CCNA2 CCNE2 POLE TFDP1 CCNB2 RB1 CCNB1 RBBP4 POLE2 CDC2 CCND1 CDT1 CHEK1 FAF1 CDC25B POLA1 SMC3 MSH6 RFC3 RFC4 BARD1 FANCG SAP30 HMGB2 PCNA PRKDC TFDP2 CDK6 E2F3 MDM2 CCNE1 H2AZ1 RBP1 ZNF655 SKP2 PRIM1 CDKN1A SIN3A MCM7 ORC1L MCM3 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260211%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MMAA MMACHC MMADHC TCN2 MTR CD320 TCN1 CUBN CBLIF OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy COL1A1 COL3A1 RELA STAT3 RUNX2 FGFR4 RELB CTGF CEBPB ACAN VEGFA JUN PIK3CA KDR COL10A1 NFKB1 AKT3 MAPK1 JUND SPP1 MAPK3 VHL SOX9 FOSL2 FOSL1 FGFR2 FGFR1 CNMD P4HTM GANC DDR2 IBSP JUNB FOS NTRK1 PRKCA LAMTOR1 HIF1A NGF COL2A1 FOSB FGF23 FGFR3 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA5 ST3GAL5 ST3GAL1 NEU3 B4GALNT1 NEU4 HEXB HEXA ST8SIA1 ST8SIA6 SIAT4C B3GALT4 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260211%WP5461%HOMO SAPIENS Primary ovarian insufficiency SOX8 FOXL2 BNC1 NR5A1 WT1 AMH DCAF17 ATG9A CYP17A1 NBN LAMC1 ZAR1 ALOX12 STAG3 SLX4 BLM FANCM FANCL WRN FANCA FANCC HSD17B4 HSD17B1 RFWD3 NUP107 ERAL1 PRDM1 SALL4 ATM BMPR1A FMR1 BMPR2 BRCA2 POLR2C PCCA PCCB STAR BMP6 RAD51 NR3A2 TP63 NOTCH2 AMHR2 LMNA PRORP ANTXR1 EIF2B1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 EIF2B2 PREPL MSH4 NOBOX KHDRBS1 AARS2 EIF2B5 AIRE PPM1B HMMR WDR62 STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 TGFBR3 HROB LHX8 MCMDC2 MCM9 ELAVL2 BMP15 POLG LARS2 C1orf146 MRPS22 SIX6OS1 HAX1 PSMC3IP RECQL4 CCDC185 MGME1 C10orf2 MND1 GNAS CENPE POLR3H NLRP11 XPNPEP2 SPATA33 MST1R FSHR FIGLA DAZL CLPP GDF9 DMC1 ZP3 PGRMC1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260211%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CERS2 PLCB1 RPP38 PRKCB SPHK1 SGMS2 PRKCA CDK4 CDKN1A SGPP1 TERT RB1 UGCG CDK2 MAPK1 S1PR2 SPTLC1 GLB1 S1PR5 S1PR1 DEGS1 MTOR KDSR MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 H2AX CDKN1A MYC CDKN1B CREB1 CCND3 CCNE1 ATM RAD52 CCND1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP2369%HOMO SAPIENS Histone modifications H3C8 EZH2 SET SUV39H2 SUV39H1 SETD2 EHMT1 H3C15 EED KMT2E SETD4 SETD5 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L EZH1 KMT2C SETD7 PRDM2 KMT2A SMYD2 KMT5B SMYD4 SMYD3 H4C7 H4C9 MLL2 SETDB1 HIST1H4L KMT5C SMYD1 SETD1B SETD1A SETDB2 SETMAR AEBP2 H3F3B ASH1L SETBP1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260211%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DICER1 DROSHA RAN TARBP2 BLADDER CANCER%WIKIPATHWAYS_20260211%WP2828%HOMO SAPIENS Bladder cancer MMP9 CDKN2A EGFR TYMP ARAF NRAS BRAF VEGFA SRC THBS1 RASSF1 CDK4 MYC CXCL8 ERBB2 HBEGF MAPK1 KRAS MAP2K1 MAP2K2 PIK3R2 PIK3R1 EGF RAF1 RPS6KA5 MDM2 CDKN1A RB1 MMP2 DAPK2 HRAS UPK3A CCND1 FGFR3 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN HIF1A VEGFA VEGFB VEGFC HES1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260211%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX14 COA6 COX1 CSRP2BP PET100 FAM36A COX10 CMC1 TMEM177 PNKD COX17 SMIM20 COX7A2 COX11 COX7B COX4I1 SURF1 COA3 COX6A1 COX8A COX2 COX6B1 COX7C COX3 COXFA4 COX5A COX19 COX16 COX18 TACO1 HIGD1A PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260211%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway HEL70 RDX ARHA SEPTIN2 MYL2 RAB35 KIF23 EZR OCRL EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260211%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects RGS16 PRL KLF2 CXCL12 ERBB4 MYB 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MEF2C PRL ASCL1 SEPTIN2 MROH2A DGKD HJURP ERFE KLHL30 THAP4 RRAGB ACKR3 RRAGD AGAP1 RAMP1 OR6B3 TRPM8 OR6B2 GAL3ST2 MTERF4 RAB27A COPS9 GBX2 SNED1 NFKBIA RTP5 RNPEPL1 PRH MYOG ING5 FARP2 SEPT6 HEL-S-28 KIF1A ILKAP AQP12B AQP12A AGXT DUSP28 CXCR4 GABARAPL2 ANO7 OTOS RPS6 ITGB3 GYS1 ARL4C USP40 ARF5 ASB18 CENPA CYTH2 SPP2 D2HGDH IRF8 ANKMY1 CYTH1 MLPH CAPN10 RAB17 ASB1 ARF1 HAMP CXCL12 TWIST2 UBE2F CALCRL UGT1A3 RAC1 NEU4 CXCL11 SH3BP4 UGT1A8 EGFR TRAF3 PDX1 PDGFA TNF DISC1 UGT1A10 BOK UGT1A1 UGT1A9 ABCA1 HES1 MAP1LC3A TRAF3IP1 MAP1LC3C EEF1A1 PER2 MYOD1 CALCA DKFZp762B153 DTYMK MAP4 JUN UGT1A4 GABARAPL1 UGT1A7 GABARAP SEPTIN4 HES6 GPC1 PDCD1 CALM1 RRAGA IL13RA1 COPS8 IL1B NEDD8 NDUFA10 PPP1R7 ITPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition ELF5 ZEB2 HDAC2 ELF3 TGFB1 SUZ12 FOXC2 HDAC1 SIRT1 EZH2 SNAI1 SNAI2 SUV39H1 TCF4 KDM1A PRRX1 TWIST1 KLF8 GSC2 SIX1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260211%WP2878%HOMO SAPIENS PPAR alpha pathway CPT2 KLK15 CYP8B1 PLTP FABP1 ACADM SLC27A1 EHHADH UGT1A9 DBI NR1C1 CDK4 MYC APOA5 RXRA NR1H3 APOC3 CPT1A CYP4A11 CDC2 CYP7A1 CCND1 APOA2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260211%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 CYP2A6 UGT1A10 CYP1A2 SULT2A1 CYP1B1 SULT1A1 SULT1E1 CYP1A1 CYP2E1 UGT1A4 UGT2B15 CYP2C19 CYP3A4 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP474%HOMO SAPIENS Endochondral ossification MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2C8 CYP2J2 COX5A CYP2C9 HEL-S-22 COX8A EPHX2 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260211%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases AKT1S1 HEL-S-68p H2AX H3F3B STAT3 KHK HEL-S-30 MYL2 SNAP23 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260211%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GTPBP4 GJB6 ITGB1 CCND2 LAMA5 NCAM1 INHBA RUNX2 PDGFA SNAI1 BMP4 SHH EDAR NFKB1 PDGFRA CTNNB1 MYC LRP5 PTCH1 TP63 SMO FGFR2 FZD1 LEF1 TNLG7C CCND1 FOXI3 ERYTHROPOIESIS%WIKIPATHWAYS_20260211%WP5607%HOMO SAPIENS Erythropoiesis IL3RA TF GDF11 HBB KITLG EPOR EPO TNFSF6 CD79A HBG2 HBD HBG1 HBA2 HBE1 GATA1 FAS GATA2 CD34 PTPRC KIT TFRC HBZ IL3 ANGIOGENESIS%WIKIPATHWAYS_20260211%WP1539%HOMO SAPIENS Angiogenesis MMP9 CREBBP ANGPT1 FGFR2 FLT1 FGF2 VEGFA PLCG1 SRC PIK3CA KDR PDGFRA HIF1A MAPK1 SMAD1 MAPK14 TIMP3 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome HMGA1 MAPK10 MAPK9 MAPK8 CRP ACLY SLC27A2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 G6PC3 PRKAG1 PRKAG2 ACACA PRKAG3 PRKAA1 G6PC2 PRKAB2 PRKAB1 ACACB G6PC1 PCK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260211%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4753%HOMO SAPIENS Nucleotide excision repair XPA XPC CUL4A ERCC5 POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 GTF2H5 CUL4B ERCC2 MNAT1 RBX1 RPA3 RPA1 ERCC1 PCNA CETN2 CDK7 POLD3 RFC1 POLD4 DDB2 POLE LIG1 POLE2 POLD2 POLE3 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260211%WP5061%HOMO SAPIENS Fatty acid transporters ACSL5 ACSL3 CD36 FABP1 FABP9 FABP4 FABP5 DBI FABP6 SLC27A4 ACSL1 FABP2 ACSL6 FACL4 GLYCINE METABOLISM%WIKIPATHWAYS_20260211%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 IL10 TMPRSS2 IL2 IL6 IL7 CXCL8 IL1B TNF ACE2 CCL2 IL2RA CCL3 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260211%WP3298%HOMO SAPIENS Melatonin metabolism and effects GSK3B IRAK1 CAMK2A CSNK1D MAP2 ASMT SULT1A1 TRAF6 FOXO1 NFKB1 CSNK1E CYP2C19 ACHE MAOA ECE1 CALM1 ADRB1 MTNR1A CRY2 MTNR1B CRY1 APOE CYP1A2 CYP1B1 SIRT1 CYP1A1 AANAT EDN1 PRKCA PER2 PER1 PER3 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260211%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PLCB4 MMP9 PIK3CD PLCB1 PLCB2 STAR NRAS KISS1R KISS1 BMP15 PIK3CA NFKB1 MAPK1 KRAS MAPK3 AMH MAP2K1 MAP2K2 CYP11A1 RAF1 ARRB2 FSHR HSD3B1 PRKCH PRKCB PRKCE PRKCA GDF9 PLCB3 HRAS PRKCQ THERMOGENESIS%WIKIPATHWAYS_20260211%WP4321%HOMO SAPIENS Thermogenesis ADCY3 ADCY1 ADCY8 ADCY6 RPS6KA2 NRAS KDM3A HEL-S-7a KDM1A RPS6KA3 PRKG1 MAP2K3 PRKAA2 SOS2 MAPK12 KRAS MAPK13 MAP3K5 ATF2 RPTOR MAPK11 MAPK14 PRKAG1 MLST8 PRKAG2 SMARCD1 SMARCC1 ACTG1 CREB3L3 SMARCD2 RPS6KB2 PRKAG3 CREB3L4 SMARCC2 PRKAA1 SMARCD3 RPS6KA6 RPS6 LIPE PRKACG ARID1B PRKAB2 RPS6KB1 RHEB CPT1C PRKAB1 AKT1S1 ADCY9 ACSL1 ACSL6 FACL4 CPT2 ACSL5 ACSL3 TSC2 TSC1 ACTL6B SIRT6 SLC25A29 ADRB3 BMP8A BMP8B ACTL6A ZNF516 PLIN1 MGLL KDM3B UCP1 PRDM16 CPT1A GNAS FGF21 MTOR PNPLA2 SLC25A20 GCG SMARCA4 ARID1A PPARG FGFR1 PS1TP5BP1 RPS6KA1 CREB3L2 CREB3 CREB1 FRS2 PPARGC1A CREB5 CNR1 DPF1 HRAS DPF3 GRB2 SMARCE1 SOS1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy LPIN1 LPIN2 LPIN3 ITGB4 BSCL2 CAVIN1 INS PIK3CA HMFN0839 DGAT1 HIF1A IRS1 FYN GRB2 DGAT2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4149%HOMO SAPIENS White fat cell differentiation RORA KLF4 CEBPA CEBPB TLE3 EGR2 FOXO1 KLF5 CEBPD INS GATA3 GATA2 EVI1 KLF15 KLF2 DDIT3 NR2F2 CTNNA1 ZNF423 RARA PPARG WNT10B NR3C1 IRF4 TCF7L1 CREB1 NR1H3 STAT5B IRF3 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260211%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma PLCB4 MYL3 ADCY3 ADCY1 PLCB1 ADCY8 PLCB2 ADCY6 MYL1 NR3C1 ADRB2 MYL4 PLCB3 CREB1 ADCY9 PRKAR1B PRKAR1A MYL2 GNAS STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260211%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 STAR HSD3B1 CYP17A1 HSD17B1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260211%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta COL1A1 MBTPS1 PPIB PLOD2 MIA3 LRP5 TMEM38B COLGALT1 MBTPS2 IFITM5 LRP6 CRTAP P3H2 P3H1 COL1A2 PLOD1 ADAMTS2 LOX P4HA1 BMP1 TNFSF11 FZD1 SP7 TNFRSF11B P4HA2 TNFRSF11A WNT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260211%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides CERS5 CERS1 CERS2 tmp_locus_29 B4GALNT1 B4GALT1 CERS3 CERS6 CERK SGMS1 SPHK1 B3GNT5 SGMS2 A3GALT2 DGAT1 UGT8 UGCG SPTLC1 A4GALT KDSR MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260211%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B FGFR2 AXIN1 MAP3K1 ROCK1 FRAT1 CTNNB1 FOXL2 MAPK1 ARHA WNT4 SRY MAPK11 GADD45G FGF9 SOX9 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260211%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 HEROIN METABOLISM%WIKIPATHWAYS_20260211%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260211%WP5174%HOMO SAPIENS Ulcerative colitis signaling NOD2 IL2RG TGFB1 HLA-DMA IL10 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL4 IL5 IFNG TNF MAF IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IF2B1 TLR4 RORC STAT1 STAT3 STAT4 IL12RB1 IL12B TYK2 IFNG IL23A IL17F CSF2 TNF STAT5B IL17A ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA2 MAPKAP1 SHC1 PDPK1 CYP3A4 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 RPTOR SHC3 PRKAG1 MLST8 PRKAG2 SLC2A4 EIF4E RPS6KB2 PRKAG3 CBLC RPS6KA4 RPS6KA6 GYS1 RPS6KA5 PRKAB2 MAP3K8 RPS6KB1 MAP3K6 RHEB MAP3K7 PRKAB1 SREBF2 PIK3R3 G6PC1 MAP3K12 HEL-S-31 FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 EXOC7 MAP4K3 MAP3K2 HEL-S-42 ABCG8 ABCG5 SCD CYP7A1 PIK3R4 SESN3 PIK3R2 PIK3R1 TRIP10 RAPGEF1 MAP3K13 GSK3A HRAS INSR MAP3K1 FOXO1 INS RPS6KA3 IRS1 MAP2K3 RXRA IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 MLXIPL FASN PRKAA1 LPL CYP2B6 ANGPTL8 NR1H3 THRA GSK3B PIK3CD MAP2K5 SLC16A2 CRK SLCO1C1 PIK3CA MAPK7 NR1A2 MAP3K14 MTOR PCK1 FOXO3A PIK3C2G PIK3C2A FBP1 CBL RPS6KA1 MAPK6 MAPK4 RICTOR SOS1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260211%WP4352%HOMO SAPIENS Ciliary landscape MCM5 MCM6 CAMK2A IFT46 CREBBP IFT70B HDAC2 WDR26 RANBP9 RMND5A RAB14 XPNPEP3 MKLN1 GID4 CTBP2 DYNC2I2 NEFL TFAP2B DYNLT1 DYNLT3 DYNLL2 NDUFA5 DYNLT2B RB1 MCM10 MYL6 DYNC1H1 DYNLRB2 EXOSC4 DNCL1 EXOC8 TBC1D4 EXOC7 YAP1 EXOC4 EXOC3 EXOC6 IFT172 MSH2 EXOC5 EXOC2 DOCK5 EXOC1 IFT74 PSMD7 TFAP2C SNAP29 DGKE UBE2D2 MCM2 SMC4 APMAP IFT81 TIPRL ERF ARL8B INTU USH1C CEP97 DDX5 HEL-S-296 IFT27 CDH23 NUP88 IFT25 AAR2 PSMD12 CTSA UBE2H TFAP2D HEL-S-91n TFAP2E PSMD13 RHBDD2 EXOC6B CNOT10 GDI1 LSM4 EHD3 CNOT1 WNK1 LCN2 RANBP10 RAC1 UQCC GLB1 ZMYND19 MYL6B RPGR TMED1 GLA DFNB31 NINL RBM14 PSMC6 NUDC ECHS1 PSMC4 CNOT6L NUP133 EIPR1 RAB3IL1 HEL113 ARFGAP3 RABEP2 CD2BP2 NME8 MAPRE2 CEP170 CCDC40 IFT70A ANKS3 VPS4A RAB21 RQCD1 RMND5B WEE1 DNPEP PGRMC2 VAPB BBIP1 GID8 CTNNB1 NEF3 YPEL5 DCAF7 TFAP2A HDAC1 MFAP1 PAFAH1B1 POM121 EIF5B TRAF3IP1 DVL3 RAB8A IFT52 BBS9 BBS7 IFT57 SNRPB2 BBS5 CEP290 IQGAP3 ACSL3 BBS4 IQCB1 IFT140 IFT80 LZTFL1 IFT43 MCM9 HEL-S-47e CBS NFKB1 EFHC2 STOM DYNC1LI1 APC BBS2 NEK8 BBS1 CALM1 MAEA ARMC8 FUZ TTC8 IQGAP1 MKS1 CLUAP1 COPS7A COPS4 IFT20 COPS6 IFT22 SSNA1 COPS5 COPS8 RALB CDR2 H3F3B NDUFA9 HTRA2 IFT56 MCM7 LRPPRC MCM3 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260211%WP5175%HOMO SAPIENS Disorders in ketone body synthesis OXCT1 ACAT1 HMGCL BDH1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5531%HOMO SAPIENS AKT signaling and ARTD family members GSK3B PIK3CD TSC2 TSC1 MAPKAP1 IKBKG FOXO1 PIK3CA PARP3 AKT3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 MLST8 PARP2 PIK3R5 PARP1 PHLPP1 PIK3C2G PIK3C2A SIRT1 PIK3C2B ATM PIK3R3 RICTOR STK11 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260211%WP5093%HOMO SAPIENS Opioid receptor pathways TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260211%WP1471%HOMO SAPIENS Target of rapamycin signaling TSC2 TSC1 PRR5 MAPKAP1 HMGCR RRAGB RRAGD DDIT4L PRKAA2 EIF4EBP1 FKBP1A RPTOR ULK2 MTOR ULK1 PRKAG1 MLST8 PRKAG2 CDC42 PRKAG3 PRKAA1 RRAGA DDIT4 PRKAB2 RPS6KB1 IDI1 RHEB PRKAB1 AKT1S1 PRKCA RAC1 RICTOR EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260211%WP4217%HOMO SAPIENS Ebola virus infection in host TLR4 ITGB1 IRF7 CREBBP EP300 CAV3 NEDD4 VAV2 SOCS3 HLA-B HLA-F HLA-G HLA-E HLA-DRA FLNA VPS11 VPS39 VPS16 AXL IKBKE VPS18 CLEC4M VPS33A ITGB3 ICAM2 RFC1 VPS41 PIK3R3 C1QBP MBL2 ITGA1 ITGA2 SCIN ITGA4 HLA-DRB5 HLA-DMA RAB7A TYRO3 HAVCR2 HLA-A IL4 CLTB CTSL HLA-C ACTN1 ACTN4 PIK3R2 PIK3R1 EIF2AK2 RAC1 MERTK IRF3 HLA-DQA2 HLA-DQA1 EGFR PAK1 RELA STAT1 VPS4A IGF1R HLA-DRB1 MFGE8 CLEC10A ICAM3 MAPK1 HLA-DOA HLA-DOB MAPK3 KPNA1 BST2 CD300A TFAP2A TIMD4 TSG101 CLEC6A RAB5A ASGR1 CD209 HAVCR1 ADAM17 HLA-DPA1 HLA-DQB2 RAB9A HLA-DQB1 ACTG1 HLA-DMB DAB2IP HLA-DPB1 FOLR1 NFKB2 NPC1 REL TIAM1 EIF2S1 RASA2 PIK3CD RELB TBK1 PIK3CA NFKB1 CAV2 ARHA RIGI CLTC CDC42 FLNB CLTA PRKRA IQGAP1 RHOB PS1TP5BP1 ITGAV CLTCL1 ITGA6 NPC2 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260211%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAPK8 STAT3 MYEF2 JUN PRKCB EDN1 PRKCE FOS MAP2K3 GATA4 PPP3CA MAPK1 ARHA RAC1 CTF1 CAMK2D MAPK11 MAPK14 NFATC4 IL6ST FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP143%HOMO SAPIENS Fatty acid beta oxidation ECHS1 CPT2 ACSL5 ACSL3 ACAT1 ACADM DLD HEL-S-49 CPT1A ACADVL LIPC ACADL PNPLA2 SLC25A20 ACADS CHKB HADHB LPL GCDH LIPF LIPE CRAT ACSS2 GPD2 DECR1 ACSL1 ACSL6 FACL4 GASTRIN SIGNALING%WIKIPATHWAYS_20260211%WP4659%HOMO SAPIENS Gastrin signaling MEF2C MEF2B ITGB1 CDKN2A KLF4 MEF2D SRC LAMTOR3 SHC1 EIF4EBP1 HDAC7 FYN PTPN11 NFKBIA RHOD ELAVL1 CDKN1B RPS6 RPS6KB1 PXN TCF4 PIK3R3 CCND1 CD44 MAPK9 MAPK8 STAT3 KAT5 IL2 CXCL8 PIK3R2 PIK3R1 MMP7 TJP1 IKBKB RAC1 EGR1 HRAS SERPINB2 BIRC5 EGFR PAK1 PTGS2 RELA SLC9A3 VEGFA FOXO1 CTNNB1 CLDN1 MYC IRS1 MAPK1 KRAS MAPK3 ATF2 MAP2K1 MAPK14 MAP3K11 BCL2L1 RAF1 ARHGEF28 GAS PRKCH TFF2 PRKCE PRKCA KIT PRKD2 PRKCQ PRKD1 BMP2 GSK3B CASP3 CHUK CRK PLCG1 BIRC2 ROCK1 BIRC3 JUN PIK3CA NFKB1 SP1 ARHA HDC BAD MTOR CDC42 ANXA2 YES1 CCKBR ARRB2 PPARG FOXO3A RHOB FOS CDKN1A CREB1 GRB2 SOS1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260211%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 DNAJB1 CRTC2 CREB1 SIK1 HDAC7 GNAS SIK3 SIK2 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP4146%HOMO SAPIENS Macrophage markers CD74 CD83 CD68 LYZ CD163 F3 CD14 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer GSK3B RB1CC1 TSC2 MAPKAP1 TFEB NRAS FOXO1 PIK3CA EIF4EBP1 KRAS BAD RPTOR MTOR ULK1 PIK3R2 PIK3R1 MLST8 CDKN1B FOXO4 FOXO3A GRB10 RHEB PIK3R3 PTEN RICTOR HRAS GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260211%WP2596%HOMO SAPIENS Gastric acid production CCK VIP SCT PGA3 PGC PGA5 MUC6 GAS CBLIF MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PIK3CD PLCG2 NCKAP1L VAV1 VAV2 TREM2 PIK3CA TREM1 LAT LYN PIK3R2 SYK PTPN6 PIK3R1 CYBB ITGAM NCF2 C1QB C1QA PIK3C2A RAC3 NCF1 NCF4 FCER1G VAV3 PIK3R3 FCGR1A CYBA RAC1 ARPC1B SIGLEC7 TYROBP C1QC MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260211%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 PTBP1 SIX4 STK11 CTDSP1 STRADB GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-133P PFKP HEL-S-30 PPM2C 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1CC1 GABARAPL2 TRAF2 ATG16L1 ATG101 GABARAPL1 GABARAP RB1 TNF PTK2B MAP3K5 ULK1 WDR45B TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NR1D1 SMAD2 STAT1 TGFBR1 ZAP70 TYK2 GATA3 IL27 SOCS3 RXRA MAPK1 LAT MAPK14 NFKBIA CRY1 RARA RUNX1 IRF4 NFIL3 IL6R IFNG HIF1A IL23A IL17F AHR PRKCQ LCK PER1 IL17A IL27RA IL2RA IF2B1 IL23R RORC RORA MAPK8 CD3G IL-21 TGFB1 CD3E HLA-DMA STAT3 CD3D TBX21 IL21R PLCG1 IFNGR1 JUN NFATC1 FOXP3 NFKB1 IL2 IL4 IL6 MTOR FOS IKBKB PPP3CA IL1B JAK1 VISUAL CYCLE%WIKIPATHWAYS_20260211%WP5534%HOMO SAPIENS Visual cycle RBP3 RDH11 RDH8 RHO RBP1 RDH5 OPN1LW RLBP1 RPE65 RDH10 OPN1MW RDH12 OPN1SW LRAT ABCA4 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260211%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCB4 PI4K2B PIK3CD PLCD3 TPTE2 PLCB1 PLCD4 IPMK PLCB2 FIG4 PI4KB PIP4K2A PLCG2 PLCG1 PIK3CA INPP5D PI4K2A INPP5E PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR8 INPP4A STM7 INPP4B PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SACM1L OCRL PIKFYVE MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260211%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 FST FGFR2 RBFOX2 CBX2 SOX8 EMX2 AMHR2 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 INSL3 WT1 WNT4 SRY MAPK11 RSPO1 AMH FGF9 SOX9 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260211%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BCL2L1 FIS1 MIB1 OPA1 BAX MTFP1 MFN2 BNIP3 MFN1 SH3GL2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260211%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ENO1 PFKM HEL-S-68p PGAM2 HEL-S-133P GPT HEL-S-49 HEL-S-30 HEL-S-87p HEL-S-162eP FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 ORAI1 KL DMP1 CYP24A1 FGFR2 ALPL FAM20C SLC34A1 ROS1 GALNT3 PTH ENPP1 NFKB1 CDKN1A NFKB2 CYP27B1 SPP1 CCND1 CYP11B2 FGF23 FGFR3 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260211%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260211%WP3929%HOMO SAPIENS Chemokine signaling ADCY3 ADCY1 ADCY8 ADCY6 STAT2 GNG3 GNG2 GNG5 CCR2 GNG4 GNG7 VAV1 GNG8 VAV2 CCL11 SHC1 c-fgr CX3CL1 CCL5 CCL19 CCL7 SOS2 CCL28 SHC4 SHC2 CCL4 SHC3 NFKBIA CCL1 NFKBIB CCL15 CXCR4 CXCR6 PRKACG PXN PIK3R3 STAT5B PTK2B CCR10 JAK3 CCR1 XCR1 GNAI1 CXCL12 STAT3 WAS CCR8 GNAI3 CCR4 RAP1A CRKL CCR3 LYN PIK3R2 PIK3R1 IKBKB RAC1 HRAS CXCL13 CXCL11 CXCL14 CCR6 PLCB4 PLCB1 PLCB2 PAK1 RELA STAT1 BRAF NRAS ADRBK1 PPBP CX3CR1 CXCL3 AKT3 MAPK1 KRAS XCL1 MAPK3 MAP2K1 CCL17 CCL20 CCL25 CCL24 CCL22 RAF1 CCL21 CCL27 PF4 CCL26 NCF1 PRKCB GNG10 CCR7 CXCR5 GNGT2 ADCY9 TIAM1 PARD3 GSK3B PIK3CD PRKCZ GRK5 CHUK GRK4 WASL PREX1 CRK ELMO1 IKBKG ROCK1 GRK1 ROCK2 DOCK2 GNG12 PRKX GNG11 PIK3CA NFKB1 GNG13 GNB2 GNB1 ITK GNB4 CXCL5 GNB3 GNB5 CDC42 PIK3R5 ARRB2 FOXO3A GNGT1 CXCL16 VAV3 IL8RB PLCB3 CXCL9 CXCR3 CSK GRB2 SOS1 CCL3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 CYFIP1 FMR1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260211%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP9 EGFR SMAD2 COL1A1 SMAD4 FLT1 RELA TGFBR3 RELB CHD2 CTGF SNAI1 VEGFA SNAI2 TGFBR1 NRP1 SRC KDR NFKB1 PLXNA2 HGF AKT3 PLXNA1 PLXNA4 CDK2 MAPK1 MAPK3 MET COL1A2 MAP2K1 MAP2K2 SEMA3A EGF CDKN1B CCNE1 GSK3A CCNE2 PECAM1 NFKB2 MMP2 RAC1 REL TGFBR2 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CDKN2A DOCK1 HGF EIF4EBP1 RPTOR PTPN11 CDKN1B HSD3B1 HSD17B3 ETV4 HSD17B7 CYP17A1 RHEB PXN RB1 PTK2B CDC2 CCND1 CHEK2 CHEK1 MAP4K1 TSC2 MAPK8 TSC1 STAT3 BAX CDC25B MSH6 MSH2 BLM ACTL6A CPN1 RAP1A KLK3 BARD1 CASP8 CRKL HSD17B4 HSD17B1 HSD3B2 PLK1 RAPGEF1 SMARCA4 ARID1A F13B NOXA1 MDM2 ATM ATR PTEN BRCA1 JAK1 HRAS ERG SMAD2 PAK1 STAT1 MRE11A RAD50 CDK4 MYC CDK2 MAPK1 MAPK3 ATF1 MAP2K1 MAPK14 MAP2K2 FOXA1 BCL2 SMARCD1 SMARCC1 RAF1 SMARCD2 SMARCC2 SMARCD3 ARID1B FKBP5 HSD17B2 CDKN2B SPRY2 CASP9 CASP3 ACTL6B CRK EIF4E1B JUN PIK3CA SP1 SPRY1 SPINK1 BAD MTOR PRKDC FOS CDKN1A RICTOR GRB2 SOS1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR FASN PRKAA1 SIRT1 HMGCR ABCA1 SIRT6 SREBF2 HMGCS1 NR1C1 NR1H3 PPARGC1A MED15 SCD MTOR SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260211%WP4496%HOMO SAPIENS Signal transduction through IL1R IRAK1 IRAK2 MAPK8 MYD88 TGFB1 RELA CHUK TRAF6 MAP3K1 MAP3K7IP1 JUN NFKB1 IL6 MAP2K3 TNF MAP3K14 MAP2K6 MAPK14 NFKBIA IRAK3 ECSIT MAP3K7 IFNB1 IL1R1 IKBKB IL1B IL1RN IFNA1 IL1A FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260211%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260211%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 ITGB1 S1PR3 S1PR4 S1PR5 HEL-S-171mP MS4A1 S1PR1 BTK EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP410%HOMO SAPIENS Exercise induced circadian regulation CBX3 NR1D2 G0S2 PSMA4 KLF9 HLA-DMA HEL-S-22 CEBPB PPP1R3C DAZAP2 BTG1 TOB1 STBD1 CLDN5 SUMO3 ERC2 RBPMS CRY2 ZFR ETV6 AAG1 CRY1 HEL-S-72p MYF6 SUMO1 UCP3 IDI1 NCKAP1 GSTM3 PIGF PURA QK3 PER2 H2BC15 PER1 VAPA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260211%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TOMM70 IKBKE IFNB1 MAVS TRAF3 RIGI TRAF6 TBK1 IRF3 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260211%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CDH17 SCEL PLA2G10 SPRR1B TSPAN8 FAM83A CYP3A7 DHRS9 TNS4 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 KRT20 LGALS4 VSIG2 S100A2 AGR2 AGR3 TFF2 CST6 FAM3D REG4 KRT6C SERPINB3 BTNL8 KRT7 GPR87 ANXA10 LYZ LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 AREG KRT6A FGFBP1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260211%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IRAK1 NLRP3 MMP9 PLA2G7 MYD88 HEL-S-134P TLR1 PIK3CA FCER1A NFKB1 F2 S100A9 IL18 IL1R1 IFNG HBEGF IL1B CCL2 F2R CCR3 TIMP1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PPP4R2 PPP4R4 PARP4 HEL-S-69 ASPHD1 TCP1 KCTD13 ZG16 INO80E MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 MAP2K3 MAPK3 MAP2K6 TBX6 CCDC6 PPP2R1A PAXIP1 KMT2C NR3C1 PAGR1 SMEK1 REL PPP2CA EZR SPN PRRT2 PPP4R3B TRAF2 TRAF6 NFKB1 CASP8 BPTF HEL-S-87p PCNA CCT7 TAOK2 PPARG MLL2 HEL70 PPP2R5D PTEN UNC13B UNC13A HEL-S-90n CCT6B HDAC3 SIAH1 DOC2A FAM57B FIMP CDIPT PPP4R1 CREATINE PATHWAY%WIKIPATHWAYS_20260211%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-29 HEL-S-20 NRF2 ARE REGULATION%WIKIPATHWAYS_20260211%WP4357%HOMO SAPIENS NRF2 ARE regulation GSK3B YES1 NFE2L2 MAPK8 INSR NQO1 CEBPB EPHB2 SRC PIK3CA SLC7A11 HMOX1 PRKCA RBX1 PGAM5 FYN MAF GCLM AIMP2 KEAP1 GCLC CANCER PATHWAYS%WIKIPATHWAYS_20260211%WP5434%HOMO SAPIENS Cancer pathways CAMK2A ADCY3 CDKN2A ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CAMK2G PDGFRA HGF SOS2 MET TGFA BCL2L11 EGF RPS6KB2 TPM3 FGFR2 NR1C2 PIK3R3 SUFU HIF1A PTCH2 KIF7 STAT5B IL2RG CXCL12 CALML6 ARAF CALML3 FZD10 STAT4 CALML4 IL12RB1 FRAT1 FRAT2 IFNGR1 IL13 EVI1 IL2 IL4 IL5 CXCL8 IL5RA KLK3 CSF2RB CRKL PIK3R2 PIK3R1 IL3 IL3RA EDNRB MGST1 FADD GSTT2 FZD1 WNT10B WNT10A NQO1 FZD3 TXNRD2 FZD2 FZD5 FZD7 FZD9 FZD8 GNA13 IKBKB HRAS APC2 PLCB4 IFNA13 IFNA14 PLCB1 IFNA16 PLCB2 IFNA17 IFNA10 PTGS2 RELA IFNA21 FGFR4 IF1AA9 NRAS BMP4 SHH WNT7B WNT7A FAS CTNNB1 IFNA8 IL7 BDKRB2 MAP2K1 MAP2K2 WNT5B GSTM2 RAF1 TNFSF6 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A RET CYCS GSK3B WNT2B PIK3CD CASP9 CASP3 CHUK APAF1 AXIN1 TRAF2 TRAF6 CRK ROCK1 ROCK2 AXIN2 WNT16 PIK3CA LRP5 ARHA LRP6 NOS2 BAD MTOR APC CDK6 JAG2 E2F3 FZD4 PPARG FGFR1 GLI3 HEY2 CBL WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 PTGER4 IFNA1 GRB2 PTGER2 SOS1 GSTT2B FGFR3 CCND2 TFG EML4 NKX3-1 PLEKHG5 IL15RA ARHGEF11 CDKN1B BBC3 SPI1 IGF2 CCND3 IL12B DDB2 IL12A IL6R CCNE2 IFNG IL23A PMAIP1 GADD45B GADD45G ARHGEF12 PTGER1 PTGER3 GNAI1 BAX PTCH1 SMO SMAD2 SMAD4 RXRA BCL2 NFE2L2 HDAC1 GNA11 NTRK1 ARNT2 EGLN1 EGLN3 RASGRP4 EGLN2 CDKN2B ELOC HMOX1 EDNRA F2R RALBP1 CTBP1 PLD2 SKP2 ARHGEF1 RALB APPL1 CREBBP HDAC2 EP300 CEBPA CTBP2 FLT3 ZBTB16 RARA RUNX1T1 PRKACG RPS6KB1 CCNA2 RB1 JAK3 CCND1 IL2RA IL2RB IL15 MSH6 MSH2 MAX RASGRP3 TPR VHL GADD45A F2RL3 MDM2 MGST3 MGST2 GSTM3 PTEN BRCA2 GSTM5 MMP2 RAC1 MMP3 JAK1 TGFBR2 NCOA1 RALA EGFR FLT3LG BAK1 STAT1 PML DCC MSH3 VEGFA RAD51 HEL-S-125m BCL2L1 GSTA5 GSTA4 KPG_010 RUNX1 GSTA3 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 F2 GNGT2 NFKB2 KIT VEGFB VEGFC HHIP VEGFD POLK KITLG HEL-S-22 CSF3R EPO IFNAR2 BIRC2 COL4A2 BIRC3 COL4A1 COL4A4 COL4A6 IFNAR1 CSF1R TXNRD3 IL7R HSP90AB1 FLT4 LAMC2 ITGAV CDKN1A ITGA6 LAMA1 LAMA4 LAMA3 ITGB1 LAMB3 LAMB2 STAT2 EPOR ALK ERBB2 NFKBIA CTNNA1 CTNNA3 CTNNA2 CXCR4 RPS6KA5 ITGA2B RAC3 E2F2 IFNA6 IFNGR2 LAMC1 FH CKS1B ITGA2 TRAF1 TRAF4 COL4A3 TRAF5 RARB COL4A5 BIRC7 MAPK10 RXRB RXRG LAMA5 MAPK9 MAPK8 LAMB4 TGFB1 STAT3 CCDC42 GNAI3 JUP CASP8 BDKRB1 LAMB1 KNG1 CCNE1 EDN1 BIRC5 CSF2RA TRAF3 PDGFA GSTM1 BRAF IGF1 TGFBR1 FOXO1 IGF1R RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 NR3A2 AGTR1 IL6ST NOTCH2 NOTCH3 CCDC6 NOTCH1 LEF1 PRKCB HES1 HES5 PRKCA TCF7L2 TERT TCF7L1 ADCY9 GSTM4 BMP2 KEAP1 LPAR1 PLCG2 PLCG1 IKBKG JUN SKP1 PAX8 GNG12 GNG11 NFKB1 GNG13 RBX1 IL6 SP1 GNB2 GNB1 IFNA2 GNAS GNB4 BCR GNB3 GNB5 PIM1 PIM2 GNGT1 HEL-S-21 FOS IL13RA1 PLCB3 DAPK2 CAMK2D TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260211%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 LEP LPIN1 MAPK8 PPARG INSR NR3C1 CEBPA CEBPB FOXO1 CEBPD IL6 IRS1 RXRA CREB1 TWIST1 PPARGC1A TNF PCK2 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260211%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 CREB3L3 CREB3L4 RELA RELB IL10 CREB3L2 NFKB1 CREB3 NFKB2 IL6 CREB1 IL1B MAPK12 REL CREB5 MAPK13 CCL2 MAPK11 MAPK14 CD14 ATF4 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260211%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CDC45 MRE11A PML FOXM1 SMARCAL1 RAD50 RAD51 CDK2 DCLRE1A RPA1 UBE2D3 HUS1 FANCD2 HERC2 TOPBP1 CLK2 RECQL EEF1E1 CLSPN TDP1 H2AX SMARCC2 FEN1 NBN SMC1A RNF8 CEP164 ATRIP SHFM1 CDC2 RAD52 CHEK2 RAD17 RAD1 CHEK1 RAD9A XPA PPM1D RBBP8 BCL6 MDC1 IKBKG TRIM28 MSH2 BRIP1 TP53BP1 MCPH1 RECQL4 WRN SP1 FANCA BARD1 UIMC1 PALB2 RFWD3 PLK1 PCNA PRKDC MCM2 PARP1 ABRAXAS1 BRCC3 MDM2 ATM ATR BRCA1 POLN BRCA2 RMI1 USP1 TOP3A XRCC5 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260211%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 ACADS ACSL3 SLC22A5 ACADM HADHB PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP11A1 SRD5A2 CYP21A2 AKR1D1 AKR1C1 HSD3B1 CYP17A1 HSD3B2 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260211%WP5087%HOMO SAPIENS Pleural mesothelioma CDKN2A EZH2 KIF23 KDR PDGFRA HGF CTBP2 PRKAA2 MET RPTOR CCL4 TGFA DEPTOR PRKAG1 MLST8 PDGFC PRKAG2 FLT3 EIF4B EGF WIF1 RPS6KB2 PRKAG3 FGFR2 RPS6 PRKAB2 RPS6KB1 RHEB PRKAB1 AKT1S1 HIF1A LIMD1 MCL1 CCND1 TNNT1 ITGA4 NF2 TSC2 TSC1 CXCL12 YAP1 FABP4 FZD10 ROR2 FRAT1 FRAT2 IL10 CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E MAX DKK1 DKK2 DKK4 SFRP4 DDIT3 BARD1 CSNK2B STK38L TNIK ULK2 ULK1 FOSL1 FZD1 CDK7 WNT10B WNT10A FZD3 MDM2 ATM FZD2 FZD5 FZD7 FZD9 UHRF1 FZD8 PTEN BRCA1 LATS1 TEAD4 MMP2 LATS2 MMP3 JAK1 HRAS TEAD2 TEAD3 MMP14 PLCB4 EGFR NTF4 FLT3LG PAK1 BAK1 STAT1 FGFR4 MAP3K1 VEGFA CSNK1A1 WNT7B SFRP1 SLC7A5 WNT7A CTNNB1 FGF10 HMGB1 RPS6KA3 CSF1 HBEGF MAP2K3 MAP2K4 CHD8 MAP2K6 MAP3K5 MAP2K1 MAPK14 MAP2K2 MAP3K10 WNT5B MAP3K11 RAF1 KMT2C EPHA2 AGER ASXL1 WDR5 BAP1 DVL1 FGF8A DVL2 DVL3 KIT WNT1 WNT3 WNT4 RBBP4 FGF6B WNT3A VEGFB MAPKAPK2 CYCS VEGFC MCU VEGFD GSK3B WNT2B PIK3CD WWC1 MAP2K5 NGFR SOX17 KITLG RB1CC1 CER1 CSF3 AXIN1 TRAF2 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA MAPK7 CSF1R NTRK2 LRP5 EFNA5 EFNA4 LRP6 FGF20 FGF22 FGF7 FGF21 CXCL5 FGF8 EFNA1 MTOR FGF9 APC EFNA3 FGF14 CSNK1A1L EFNA2 FGF13 FGF18 FGF12 FGFR1 ITGB4 FLT4 LAMC2 AMOT FGF2 FGF7B ITGAV FGF7A RASSF7 CDKN1A NGF ITGA6 FGF5C LAMA1 LAMA4 LAMA3 GRB2 CXCL1 AREG SOS1 FGFR3 NLRP3 ANGPT4 IDO1 MMP9 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 LAMB2 MEF2D BDNF SRC SHC1 SETD2 CCL5 EIF4EBP1 CCL2 MOB1A CTNNA1 CTNNA3 CTNNA2 RASSF2 RASSF3 RASSF4 BBC3 RASSF6 ITGB3 RPS6KA5 HCFC1 IGF2 PHC1 CCND3 PRSS23 IL34 MAD2L1 MAP3K6 DSC3 LAMC1 BAG2 MDK RNF2 CTHRC1 MOBKL1A ITGA1 PAK6 CDH9 CDH8 PAK4 CDH4 ITGA2 CDH10 COL4A3 CDH11 CDH12 HEL-S-31 CDH15 AJUBA COL4A5 CDH17 VGLL4 ACTA2 CIT CD44 MAPK10 CDH19 MAP4K1 CDH24 LAMA5 MAPK9 WWTR1 MAP4K2 MAPK8 SPARC MINK1 TGFB1 LIN28B BAX MAP4K3 CTGF MAP3K2 EED LAMB1 SELE TTI1 MDM4 LGALS9 SUZ12 HMGN1 CCNE1 PPARGC1A CSF2 BMI1 FGF23 FLT1 PRB1 INSR PRB2 CDH6 PDGFA CDH2 IGF1 CD47 OGT FOXM1 CDH16 FOXO1 IGF1R INS RASSF1 CDK4 MYC AKT3 CDK2 YY1 MAPK1 RYK MAPK3 ROR1 ATF2 PDGFD BCL2 ACTG1 EIF4G1 PRKAA1 SOST LEF1 NTRK1 TCF7L2 TERT NTF3 TCF7L1 PIGF KREMEN1 SENP2 SFRP5 ATF3 CXXC4 PORCN NOTUM SLC3A2 BTRC JUN NFKB1 IL6 SP1 SETD5 CTBP1 PS1TP5BP1 HEL-S-1 RPS6KA1 BTC GABPA SETDB1 CDH18 MAD1L1 ACTA1 CREB1 IL1B ACTG2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP75%HOMO SAPIENS Toll like receptor signaling TLR4 IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 TRAF3 LY96 IFNA21 IF1AA9 TIRAP MAP3K7IP1 IFNA8 AKT3 MAP2K3 CCL5 MAP2K4 MAPK1 TNF MAPK12 MAPK3 MAP2K6 MAPK13 CCL4 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B IFNA7 MAP3K7 RIPK1 IL12A TICAM1 IRAK1 IRAK4 MAPK10 MAPK9 TAB3 MAPK8 MYD88 CHUK LBP TRAF6 TBK1 IFNAR2 IKBKG JUN IFNAR1 NFKB1 IL6 TLR5 CXCL8 CASP8 SPP1 IFNA2 TLR9 TLR7 FADD FOS IFNB1 IKBKB IL1B RAC1 CXCL9 IFNA1 CXCL11 IRF3 TLR8 CD14 TLR3 CCL3 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2 EPHX2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260211%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway KIR2DL1 KIR2DL3 VAV1 PLCG1 PRKCA LCP2 IFNG CD34 CSF2 HLA-C TNF RAC1 FYN HRAS LAT TYROBP PRKCQ GRB2 SYK PTPN6 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260211%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AX H2AB1 H3C8 SUZ12 BCL6 H2AZ1 EZH2 H2AZ2 RNF2 H3C15 H2AB3 PCGF1 H3F3B MAPK1 H2AJ MAPK3 EED MACROH2A1 BCOR MACROH2A2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260211%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH COQ6 COQ2 SLC52A1 PDSS1 ETFA COQ8A FLAD1 COQ9 APTX COQ7 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260211%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260211%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260211%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMB3 LAMA5 LAMB2 SRC SHC1 IRS1 EIF4EBP1 MAPK1 ARHA MAPK3 PTPN11 MAPK14 MTOR PIK3R2 PIK3R1 LAMB1 ITGB4 LAMC2 LAMC1 PRKCA ITGA6 RAC1 LAMA1 HRAS LAMA3 GRB2 SOS1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260211%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection HEL-68 HCLS1 TLR4 KRT18 TUBA2 ITGB1 ARPC2 ARPC3 TUBA8 LY96 WASL ROCK1 WAS ROCK2 TUBB8 TUBA1C CTNNB1 CLDN1 TUBB6 TUBA1B TLR5 TUBA1A ARHA FYN TUBB1 ARHGEF2 CDC42 TUBB ACTG1 TUBA4A YWHAQ TUBB2A PS1TP5BP1 NCL NCK2 TUBAL3 NCK1 YWHAZ PRKCA TUBA3E ARPC5 ARPC1B TUBB4B EZR CD14 TUBB4A ARPC4 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 MTARC2 MOCS1 XDH GPHN AOX1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260211%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds GSK3B FZD1 MBOAT1 DKK3 LEF1 AXIN1 CSNK1A1 FZD7 FZD8 TCF4 CTNNB1 DVL2 SFRP4 WNT1 TNKS APC CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP536%HOMO SAPIENS Calcium regulation in cardiac cells RGS16 CAMK2A ADCY3 ADCY1 CACNB1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G RGS10 CASQ1 RGS11 FKBP1A GJB1 ADRA1B ADRA1A GNAZ GJB6 GNAI1 GJA9 ATP1B3 STIM2 GJC1 GJB4 GJB3 GNAI3 ANXA6 GJD2 HEL-S-99n CASQ2 ATP1A4 PLN KCNJ3 KCNB1 CXNA GNAO1 ADRB1 ATP1B2 ATP1B1 CAMK1 FXYD2 CHRM1 ATP2B3 ATP2B2 ATP2B1 HEL2 GJB2 ORAI1 SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 CACNA1C RGS6 RGS7 PRKCH PRKCB GNA11 PRKCE PRKCA CACNB3 CACNA1S ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ CHRM2 CHRM3 GRK5 GRK4 ADRA1D SFN ADRB3 GNG12 GJA3 GNG11 GJA5 GNG13 GJA8 PKIB CXNO PKIA GNB2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 CACNA1B RYR1 RYR2 ATP2A2 CACNA1A ARRB2 RYR3 GNGT1 KCNJ5 YWHAQ HEL-S-1 YWHAG CHRM4 CHRM5 GJA4 YWHAZ ADRB2 PLCB3 RGS18 RGS17 CAMK2D RGS14 CAMK4 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling EGFR CREBBP AGTR2 CSF2RA F2RL2 MAPKAP1 IL10RA SRC TYK2 PDGFRA SOCS3 MAPK1 PTPRC IL11RA MAPK12 MAPK3 MAPK13 CTF1 RPTOR GHR IL15RA MAPK11 MAPK14 DEPTOR AGTR1 IL6ST MLST8 IL10RB IFNGR2 PRKCB IFNLR1 AKT1S1 IL6R OSMR JAK3 IL20RA IL20RB IL27RA IL2RA IL2RB MAPK10 MAPK9 IL2RG MAPK8 STAT3 CSF3R IFNAR2 IL21R CNTFR TRIM28 IFNGR1 IFNAR1 MAPK7 PTPRT IL5RA MPL CSF2RB MAPK15 IL22RA1 F2R MTOR IL9R IL3RA IL7R SETD7 F2RL3 DUSP2 MAPK6 MAPK4 JAK1 RICTOR DOPAMINE METABOLISM%WIKIPATHWAYS_20260211%WP2436%HOMO SAPIENS Dopamine metabolism DDC NQO1 MAOA PRKACG PPP2CA TH HEL-S-44 TYR HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BIRC5 CD44 CASP9 SMAD4 MAPK8 PTGS2 CASP3 TGFB1 STAT3 MYOF RRM2 VEGFA COL4A2 TGFBR1 VAV2 BIRC3 JUN NFKB1 FRZB MYC IL6 CXCL8 MAPK3 NOS2 PTPN11 MAPK14 BCL2L1 HNF1A LEF1 TNFSF6 E2F2 HEL-117 IL6R CDKN1A BRCA1 HIF1A CXCR1 RAC1 JAK1 GRB2 CCND1 SOS1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260211%WP5355%HOMO SAPIENS Metabolic epileptic disorders ECHS1 ACAT1 PSAT1 PSPH ENO1 HEL-S-68p GLDC AMT HEL-S-30 PHGDH HEL-S-20 SLC2A4 ETHE1 SQOR SUOX SPCS1 CDO1 GCDH HEL-S-51e LDHB MPC1 HEL-S-133P GPT HK3 DHTKD1 G6PC1 HEL-S-32 GCK SLC25A15 ASL MOCS2 MOCS1 SFXN1 GPHN ARG1 HEL-S-162eP CBS PFKL SLC25A1 ENO2 PFKM ENO3 SLC25A5 MPC2 PGAM2 ALDH7A1 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-87p CTH MOCS3 HK2 AASS SLC7A2 HEL60 PCK1 PDHA1 MDH2 GOT2 PKLR ASS1 XDH GLUD1 ALDOB SHMT1 FBP1 PC SLC2A3 BTD HLCS SLC2A2 OTC GLS2 AADAT DLAT MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260211%WP2003%HOMO SAPIENS miR targeted genes in leukocytes AP3D1 ARHG ARCN1 WDR11 CEBPB PPIB LAMTOR3 PLXND1 TUSC2 ARID4B HEL-S-30 VPS39 FADS1 TNLG5A TPM3 GYS1 RAB34 MAP3K8 ANAPC1 TMED10 RAB5C ADIPOR2 SLC1A4 CORO1C SAC3D1 MCL1 MPDU1 CD164 SNAP23 BRPF3 HMGA1 CAP1 TBCA IGF2R BCL6 MENT SLC25A1 ADPGK THBS1 TNFAIP2 ADAR LMNB2 TUBA1A TMEM109 ACP2 PRSS21 SCYL1 TXN2 RFT1 DDX5 UNC93B1 GNA13 DNAJB1 POLR2C SPTLC1 ATP6V1F CDIPT ATP6V0E1 POLE4 FMNL2 SERPINE2 CTNNB1 DCAF7 PNP CHORDC1 MAPK14 GOLGA7 CDK5RAP3 BCL2 PPIF IFRD1 LPL PISD MTHFD2 TYMS RTN4 POM121 MRPL20 SLC7A11 RDH10 KCNN4 SNX6 PHC2 SFXN1 HEL-S-26 HEL-S-47e ARF4 TRAM1 HMOX1 MRC2 TMEM43 TMED3 SH3BGRL3 CTSC CDK6 ANXA2 ATP2A2 PRPF40A YWHAQ SLC7A6 CDCP1 FRG1 PTRH1 NELFCD HEL-S-66 PTPA USP1 CA12 SHOC2 SRSF10 APOPTOSIS%WIKIPATHWAYS_20260211%WP254%HOMO SAPIENS Apoptosis BIRC5 IRF7 CDKN2A BAK1 RELA TRAF3 CASP10 MAP3K1 IGF1 IGF1R FAS LTA MYC MAP2K4 TNF NFKBIA IRF6 BCL2L11 TP63 NFKBIB BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO IGF2 TNFSF6 CASP6 IRF4 RIPK1 IRF1 PMAIP1 TRAF1 TNFRSF10B MCL1 CYCS MAPK10 BNIP3L CASP9 CASP3 TP73 CHUK APAF1 BAX TRAF2 HRK IKBKG BIRC2 PRF1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 TNFRSF25 CASP8 CRADD BAD SCAF11 PIK3R1 BCL2L2 IRF2 FADD HELLS MDM2 TNFRSF21 TRADD IKBKB TNFRSF1B IRF3 NFKBIE OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F8 CYP2C8 CYP2J2 CYP4F11 CYP46A1 CYP26A1 CYP2S1 CYP27C1 CYB5R3 CYP7B1 CYP26B1 CYP4V2 CYP27B1 CYP2C19 CYP3A7 CYP3A4 CYP2W1 CYP11B2 CYP27A1 CYP2R1 CYP3A43 CYP2A7 CYP8B1 CYP26C1 CYP2C9 CYP2A6 CYP2B6 CYP17A1 CYP2A13 CYP4A22 CYP2F1 CYP4B1 CYP20A1 CYP4F2 CYP4A11 CYP4F12 POR CYP51A1 CYP24A1 CYP7A1 CYB5R1 CYP11A1 CYB5R4 CYB5B CYP1A2 CYP1B1 CYP1A1 CYP4Z1 CYP2E1 CYP2U1 CYP4F22 CYP4X1 CYP2C18 CYP4F3 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260211%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CREBBP EP300 FGFR4 CEBPA SETD2 MYC ERBB2 KDM6B ARID4B MYB MAP2K2 NCOR1 NFIB ARID5B NOTCH1 RAF1 KMT2C TLK1 SMC1A MYBL1 CHEK2 CHEK1 PIK3CA BCORL1 MAX FGF16 PRKDC FBXW7 MAML3 SRCAP JMJD1C CTBP1 HIST1H1E ARID1A CMTR2 MAGI1 DTX4 FOXO3A HIST1H2AK INSRR FOXP2 MORF4L1 ATM KAT6A MYCBP MGA KANSL1 UHRF1 PTEN BRCA1 HRAS BCOR SMARCE1 ERBIN MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MYLK PLCB2 RCAN1 CISH MYEF2 IGF1 MAP3K7IP1 IGF1R LIF CTNNB1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 GATA4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 CTF1 MAP2K1 MAPK14 NFATC4 MAP2K2 CDK9 IL6ST EGF RAF1 IKBKE FGFR2 PRKCB DVL1 PIK3R3 WNT3A EIF2B5 GSK3B PIK3CD NPPB MAP2K5 MAPK8 TGFB1 CHUK STAT3 IKBKG ROCK1 ROCK2 PIK3CA MAPK7 NFKB1 LRP5 LRP6 ARHA MAP3K14 MTOR PIK3R2 PIK3R1 CALM1 FZD1 CDK7 FZD2 FGF2 NPPA EDN1 IKBKB PPP3CA MAPK4 RAC1 CAMK2D MYLK3 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260211%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK PDHA1 TPK1 SLC19A3 DKFZp667O1614 HEL107 SLC19A2 OGDH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP619%HOMO SAPIENS Type II interferon signaling IFI6 STAT2 STAT1 IFNGR1 ISG15 SOCS3 SOCS1 HLA-B MHC2TA NOS2 IFNA2 PTPN11 TAP1 CYBB IRF2 OAS1 SPI1 IRF9 IFIT2 H4C9 IFNGR2 IRF4 EIF2AK2 IRF8 IRF1 GBP1 IFNB1 IFNG IL1B JAK1 CXCL9 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260211%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 ITGB1 CDKN2A EGFR HEL113 IGF2R STAT1 BAX IGF1 CLDN7 JUN IGF1R SRC NFKB1 CTNNB1 CLDN1 CDK4 CDK2 TLN1 PIK3R1 NOTCH1 BCL2 CDKN1B PSEN2 ABCC1 IGF2 CCNE1 MDK PRKCA PECAM1 PTEN TACSTD2 RB1 ACVRL1 RAC1 PAK4 CCND1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260211%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 LPAR1 JAG2 ALPL PLAT CALU SOX6 VEGFA GJA5 DLL3 DLL4 ITGA1 MGP FGFR3 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway ACAT1 ACAT2 HMGCR GGPS1 IDI1 FDPS MVK HMGCS1 FDFT1 IDI2 PMVK MVD HMGCL FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP STAT1 SNAI1 BMP4 ATG5 MAPK1 MAPK12 IHH MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 FGF9 MAP2K2 SOX9 RAF1 FGF18 PTHLH RBL1 CDKN1A NPR2 PTH1R PPP2CA BMP2 THRA FGFR3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP558%HOMO SAPIENS Complement and coagulation cascades TFPI C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260211%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PAK1 ZAP70 GRAP2 LCP2 CDK4 CARD11 BCL10 PTPRC TNF FYN MAPK3 NFATC2 LAT MAP2K1 NFKBIA CTLA4 MAP2K2 PTPN6 RAF1 MAP3K8 MAP3K7 CD40LG IFNG PRKCQ LCK GSK3B DAG1 MAPK9 CHUK CD3D CD8A IKBKG PLCG1 IL10 JUN PIK3CA NFKB1 IL2 IL4 IL5 RRAS MAP3K14 ITK PDCD1 ICOS CALM1 CBL NCK1 FOS IKBKB CHP1 CSF2 AHSA1 GRB2 SOS1 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260211%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte LEP SMAD9 BMP7 ZNF423 PPARGC1B PPARG DGIC ZIC1 CEBPA CEBPB BMP4 CEBPG DKFZp781O1323 SLC7A10 PRDM16 PPARGC1A HSPB7 SMAD1 CIDEA EBF3 BMP2 HOXC9 HOXC8 MPZL2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4255%HOMO SAPIENS Non small cell lung cancer CDKN2A EGFR BAK1 NRAS BRAF ALK RASSF1 PDPK1 CDK4 HGF AKT3 RXRA ERBB2 MAPK1 EML4 SOS2 KRAS KIF5A MET MAPK3 HEL-S-61 MAP2K1 STK4 MAP2K2 TGFA EGF RAF1 E2F2 PRKCB DDB2 PRKCA RB1 STAT5B GADD45B JAK3 GADD45G CCND1 RET CYCS RARB PIK3CD FHIT POLK RXRB CASP9 RXRG CASP3 STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA CASP8 BAD GADD45A CDK6 E2F3 CRABP2 CRABP1 FOXO3A CDKN1A HRAS GRB2 SOS1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260211%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MYRIP SYTL5 RPH3A MLPH UNC13D MADD TBC1D10A SYTL2 EXPH5 RAB27A RAB27B SYTL1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP45%HOMO SAPIENS G1 to S cell cycle control MCM5 MCM6 CDKN2A CCND2 CDC45 WEE1 CDK4 MYC CDK2 RPA3 RPA1 CREB3L3 CDKN1B CREB3L4 CCND3 E2F2 CCNE2 POLE TFDP1 CDKN2D RB1 CCNB1 CDKN2B POLE2 CCNG2 CDKN2C CDC2 CCND1 PRIM2 POLA2 MYT1 CCNH CDKN1C MNAT1 GADD45A PCNA TFDP2 MCM2 CDK6 E2F3 CDK7 MDM2 CCNE1 ATM PRIM1 CREB3 CDKN1A CREB1 ORC6 ORC3 ORC2 MCM7 ORC1L MCM3 ATF6B DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260211%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260211%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response IRF7 HDAC2 LAG3 STAT2 EP300 STAT1 CXCL2 TRAF3 AP1G1 NUP98 RAE1 PPBP CXCL6 IFITM1 CXCL3 CCL5 TP53I3 TNF ACE2 CCL2 CCL4 TFAP2A LARP1 MX1 CD160 PF4 IFIT2 RIPK1 IL6R hEMMPRIN TRAF5 TANK TGFB1 CXCL12 TRAF2 TRAF6 TBK1 IFNAR2 DHX58 TRIM25 IL10 HAVCR2 IFNAR1 NFKB1 IL6 CXCL8 MAVS CASP8 RIGI CXCL5 TLR7 FADD TRADD IL8RB IFNB1 CSF2 JAK1 CXCL9 CXCL17 CXCL13 CXCL11 CXCL1 IRF3 CCL3 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP9 CASP3 BBC3 APAF1 TP53AIP1 BAX MDM2 ATM EI24 SHISA5 CYS1 ZMAT3 PERP DDB2 PTEN PMAIP1 SIAH1 CASP8 TNFRSF10B SESN3 CHEK2 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260211%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP LRP5 LRP6 PORCN TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP465%HOMO SAPIENS Tryptophan metabolism ECHS1 TDO2 IDO1 ACAT1 STAT1 ASMT TPH2 TPH1 AOC1 ALDH8A1 IL4I1 DLD DDC MAOA AOX1 ALDH2 GOT2 GCDH CYP1A1 KYAT3 KYAT1 AANAT INMT AADAT HAAO AHR KMO KYNU AFMID IDO2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260211%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CHEK1 MAPK8 PTGS2 TSC1 PINK1 IKBKG FOXO1 PIK3CA HMOX1 NFKB1 GSX1 IPCEF1 IL6 PIP CXCL8 MAP2K3 CDK2 MAP2K4 TNF NOS2 MAP3K5 ATF2 MAPK14 MTOR BCL2L1 BCL2 NFE2L2 NQO1 RPS6KA5 SIRT1 MDM2 CCNE1 RHEB ATR NRF1 FOS CDKN1A PTEN IKBKB CREB1 KEAP1 IL1A UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP9 CAMK2A EGFR SMAD2 CREBBP EP300 RELA CTNNB1 HDAC5 TRPC4 CDK2 MAPK1 TNF MAPK3 PTPN11 MAPK14 AGTR1 CYBB BCL2 NCF1 NCF4 ABCA1 AIFM2 CYBA COL2A1 CDC2 VCAM1 GSK3B ACTA2 NPPB COL1A1 CASP9 MAPK9 COL3A1 MAPK8 CASP3 TGFB1 CHUK ALOX5 STAT3 BAX ESPL1 HMOX1 NFKB1 PLN IL6 UTS2R DDIT3 ARHA PCNA NCF2 UTS2 CCNE1 NPPA GSK3A NOX4 PTEN IKBKB MMP2 IL1B HSPA2 IRF3 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes ACSL5 ACSL3 STAR FABP4 LPA DBI SLC27A2 SORT1 APOC2 SLC27A3 SOAT1 APOC1 LIPA PCSK9 APOA4 SCARB1 APOB LDLR MYLIP FABP1 APOE SLC27A1 ABCA1 SOAT2 SLC27A4 ACSL1 STARD3 FABP2 ACSL6 NPC2 NEPHROGENESIS%WIKIPATHWAYS_20260211%WP5052%HOMO SAPIENS Nephrogenesis BMP7 TCF21 SIX2 WNT9B RSPO3 FOXD1 OSR1 ALDH1A2 GREB1L PAX2 MEIS1 FGF20 WNT4 WNT3A RSPO1 FGF8 NOTCH2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260211%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CCL14 CCL13 IL10RA ACKR3 CCL8 CCL7 CCL4 CCL1 CCL18 TNFRSF14 CCL15 TNLG5A LEPR ACVRL1 CCR10 CCR1 XCR1 IL2RA IL2RB IF2B1 IL23R IL15 GDF11 TNFRSF10A CD27 IL2RG IL-21 CXCL12 IL18RAP IL21R IL12RB1 IL10 CCR8 IFNGR1 EDAR CCR4 IL13 BMP8B IL2 IL4 IL5 CXCL8 IL5RA CSF2RB CCR3 IL3 IL3RA GH1 IL9 BMPR1A BMPR2 TNLG7C TNFRSF19 LTB IL1RN CXCL17 CXCL13 IF2D TGFBR2 CXCL14 IF2G IL36A CCR6 IL1A IL36B INHBA GDF5 IL36RN IL36G PPBP INHBB IFNW1 BMP4 IL1F10 CXCL6 IL24 FAS IF1IB1 IL27 CX3CR1 CXCL3 IL7 PF4V1 CSF1 IL19 XCL2 TNF IFNK XCL1 IFNL2 IFNL3 CCL20 ACKR4 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 TNFSF6 TWEAK TNFRSF12A IL1R1 ACVR2A IL27RA NGFR CSF3 CSF3R EPO IFNAR2 CNTFR TNFRSF1A IFNAR1 BMP3 CSF1R GDF10 CXCL5 GDF3 TPO IL7R NODAL TNFRSF21 IFNB1 NGF IL1R2 CXCL9 CXCL1 ACVR1B CCL3 TACI PRL CNTF EPOR CXCL2 CCR2 PRLR CCL23 CCL11 LIF LTA CX3CL1 CCL19 CCL5 CCL28 CCL2 IL15RA GHB2 IL18R1 GHR AMH CXCR4 CD40 IL25 CXCR6 IL34 IL10RB IFNGR2 IFNLR1 BMP10 TNLG7A IL6R CD40LG IFNG IL23A IL17F IL17D IL17C TNFRSF10B IL17B IL20RA IL20RB IL17A TGFB1 TNFRSF4 TNFRSF9 MPL ACVR1 IL22RA1 IL9R ACVR2B TNFSF11 GDF15 TNFRSF11A IL1RL2 TNLG2B CSF2 CXCL11 CSF2RA IL17RC IL17RB BMP6 IL17RA TGFBR1 IL11 IL11RA gdf7 TNFSF14 GDF1 GDF6 RELT IL6ST CLCF1 TNLG8A TNFRSF8 IL13RA2 TNFRSF17 BMP7 INHBC BMP5 TNFSF10 INHBE TNFRSF18 ACVR1C LTBR TNFRSF11B AMHR2 CCR7 IL1RL1 CXCR5 GDF8 LEP ANP32B BMP15 TNLG1B IL6 TNFRSF25 CCR5 IFNA2 TNFRSF13C TNFRSF10C TSLP CXCL16 CCL4L2 IL13RA1 IL8RB GDF9 IL18 TNFRSF1B CXCR1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260211%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNAI1 GNG2 KCNK9 CHRNA5 TH CHRNA6 KCNK3 PPP1R1B SLC18A2 DDC DRD2 DRD3 CHRNB2 CHRNA3 DRD4 GNB1 CDK5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGA4 ITGB1 HLA-DMA CD63 CD151 SHH HBEGF LGALS3BP HLA-DRA CHST6 EXT1 CRY2 ALKBH3 HLA-DMB CHST1 LEF1 GLI3 CD82 MAPK8IP1 IGSF8 NRXN1 CD19 SPPL2C B4GALT4 PRDM11 ACCS PHF21A C11orf96 ALX4 TP53I11 LARGE2 EXT2 PEX16 IZUMO1 ITGA6 SDCBP SLC35C1 SYT13 VANGL1 MS4A1 FREY1 REST SLC25A17 B4GAT1 TIMP1 B3GNT7 PEX3 TSPAN18 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260211%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CXCR4 TGFB1 CCR2 IL12RB1 IFNGR1 IFNGR2 IL12B CCR7 CCR4 IL12A IL2 IL4 IL5 CD40LG IFNG CCR5 CSF2 CXCR3 CCL4 IL18R1 CCR3 CCR1 CCL3 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA2 PDHA1 CHKA ACHE PEMT ChAT MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260211%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 SOCS3 MYC STAT3 CHI3L1 BAX IL6ST AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260211%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAG2 CSN1S1 EIF4E EIF4G1 TSC2 EEF2 PRKAG3 PRKAA1 CSN3 EEF2K PRKAB2 RPS6KB1 PRKAB1 CSN2 PRKAA2 RPTOR MTOR EIF4A2 PRKAG1 MLST8 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis IRAK1 TLR4 NFKB2 APOE RELA SPI1 TRAF6 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway EDN2 TSC22D3 PTGS2 SNAI2 POU5F1 B3GNT5 CDC42EP3 ACKR3 TNFAIP3 PMP2 ANGPTL4 MFGE8 IL11 RXRA NR1I3 FGD4 GPR153 CCL2 SERTAD2 CCL20 CAVIN2 PTGES3 NR1i2 KTN1 RGS2 NR3C1 DNER SCNN1A NFKB2 SLC26A2 ABHD2 DNAJC15 GADD45B ARL5B ZIC2 MGAM SRGN TGFBR3 PPP1R14C ALOX5AP NAV3 ADGRF4 BIRC2 CDKN1C BIRC3 JUN PRRG4 STOM S100P SPRY1 THBD TNS4 PDE4B BHLHB2 SLC19A2 PLK2 AMIGO2 CPEB4 EPB41L4B ENC1 ANKRD1 FGFBP1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260211%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation NDUFB10 MEF2D RELA VAV1 SH2B3 ZAP70 GRAP2 TNFAIP3 PDPK1 LCP2 CARD11 BCL10 SOCS1 LAT NFKBIA PTPN6 CDKN1B CUL5 MAP3K8 DGKZ SH2D1A REL PRKCQ LCK RASA2 DGKA TMEM222 MAP4K1 ARIH2 CD3G UBASH3A CD3E CHUK RPRD1B CD3D FIBP CD8A CD5 TRAF6 AGO1 IKBKG PLCG1 NFKB1 ARHH MAP3K14 ITK PIK3R2 PIK3R1 RNF7 GNA13 IKBKB GRB2 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP322%HOMO SAPIENS Osteoblast signaling IBSP PDGFRA COL1A1 TNFSF11 ITGB3 BGLAP PTH1R PTH TNFRSF11B SLC17A2 ITGAV FGF23 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU2 HEXB SCARB2 HEXA GM2A PSAP NEU1 NPC1 GLB1 NEU3 NEU4 GLA LIPA NPC2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260211%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits SRC NOTCH1 TCF7L2 TCF7L1 CXCR4 TNC LEF1 POSTN VHL VEGFA VCAM1 CYTIP GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP100%HOMO SAPIENS Glutathione metabolism GSTM2 GSTT2 GPX2 GSTA5 GSTM1 GPX3 OPLAH HEL-S-26 HEL-S-64p GPX1 GPX4 GCLM HEL-75 GCLC STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260211%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPIN1 INSIG1 NR1H2 INS DBI YY1 PRKAA2 PRKAG1 PRKAG2 SCARB1 CAMP ACACA LDLR FASN PRKAG3 PPARGC1B PRKAA1 LPL SIRT1 PRKAB2 IDI1 FDPS NFYA PRKAB1 SREBF2 HMGCS1 MVD SAR1B HEL-S-32 CDK8 CYP51A1 MBTPS1 HMGCR ACLY PIK3CA SAR1A RNF139 SEC23B FDFT1 SEC31B SEC31A AMFR SP1 SEC24C MBTPS2 SQLE MED15 FGF21 SCD MTOR ACSS1 PPARG GPAM RBP4 SEC23A GSK3A CREB1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260211%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260211%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 IRAK4 IRF7 STAT2 MYD88 STAT1 TRAF3 TRAF6 TBK1 IFNAR2 TMPRSS2 TYK2 IFNAR1 MAVS TREML4 RIGI ACE2 TLR9 TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 JAK1 IFIH1 IRF3 TLR3 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260211%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy GLS RPS6KA2 ARAF BRAF PFKFB2 DLD RPS6KA3 MAPK1 HEL-S-30 MAPK3 CPT1A RPTOR MAP2K1 MTOR MAP2K2 HEL-75 MLST8 ACSS1 PDHA1 RAF1 NAMPT PKLR SLC16A3 RPS6KA1 LDHB HEL-S-304 HEL-S-133P DLAT PPARGC1A GPX4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260211%WP1993%HOMO SAPIENS Angiogenesis overview PLA2G1B MMP9 BMX ANGPT1 PAK1 VEGFA GRB7 SRC KDR SHC1 PLXND1 PDPK1 MAP2K4 MAPK1 KRAS MAP2K6 ATF2 PTPN11 MAPK11 MAP2K1 MAPK14 RAF1 SLIT2 GRB14 MAP3K7 PXN F2 PRKCA ROBO4 PTK2B PIK3CD DAG1 MAPK8 CRK WAS PLCG1 NRP1 SHB TIMP4 BAD VHL MTOR APC CDC42 SEMA3A IQGAP1 FGFR1 ROBO1 NCK1 NOX4 MMP2 FRS2 RAC1 GRB2 SOS1 MMP14 CCL18 SIGNALING%WIKIPATHWAYS_20260211%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 MMP2 CDH2 AK4 PTK2B CCR8 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP5276%HOMO SAPIENS Estrogen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 UGT1A10 CYP1A2 HSD17B3 CYP1B1 HSD17B7 SULT1E1 HSD17B2 CYP2C19 CYP3A7 UGT2A2 CYP3A4 HSD17B10 HSD17B4 HSD17B1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260211%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 MAD1L1 PTTG1 STAG1 CENPE CDC20 BUB1B SMC3 APC ESPL1 MAD2L1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP334%HOMO SAPIENS GPCRs class B secretin like GPR64 PTH2R CALCR ADGRL4 CRHR1 GLP1R ADGRL2 ADGRL3 ADGRE2 GHRHR PTH1R ADGRE5 ADCYAP1R1 ADGRL1 VIPR2 CRHR2 GIPR CALCRL GCGR SCTR TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways BCAT2 PSAT1 BAAT DHFR PSPH AMT CHDH GPX1 PHGDH HEL-S-44 HEL-75 GCLC pcap GAD2 CDO1 MTR HEL-S-75p GAD1 HEL-S-51e MTHFD2 TYMS DNMT3L GPX6 MAT1A HEL-S-64p GPX4 HEL-S-61p GPX2 CBS BCAT1 ALDH7A1 DNMT3B CTH GCLM AGXT2 PCYT1B CHKB AHCYL1 PCYT2 SLC25A48 CHKA BHMT2 ETNK1 AHCYL2 GPX7 PEMT MTHFD1 MTHFD2L CHPT1 GPX3 SHMT1 MTHFD1L CEPT1 HEL-S-182mP 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome NLRP3 GDF5 ChAT DKFZp781O1323 JUND ATF2 BCL2 CUL5 SMARCC2 SIRT1 EIF4ENIF1 ELOA BMP2 SF3B1 MYBBP1A MAPK8 ERCC5 RIF1 SIRT6 NEO1 HSF1 MYO1C MEN1 DLD SMAD1 PCNA SMAD9 DDX21 OGDHL FAM170B CEFIP BMPR1A VSTM4 RGMB BAZ1B NOG WDFY4 PARG LRRC18 SLC18A3 ARHGAP22 HSF4 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 ITCH UVSSA MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260211%WP2857%HOMO SAPIENS Mesodermal commitment pathway ARL4A WDCP MIXL1 C9orf72 KLF4 KLF5 GATA3 RGS10 SETD2 HAND1 CTBP2 RPL38 LEFTY1 AMH LEFTY2 ZIC5 TBX6 NR2A1 HES7 SESN1 GATA6 TCF4 C1QBP TBX1 FOXH1 TBX3 CCND1 RARB PLCH1 YAP1 CRTC1 PIAS1 TRIM28 NABP2 DKK1 ACVR1 SMAD1 DNMT3B ACVR2B SCHIP1 SMAD6 BHLHB2 FZD5 BMPR1A FZD8 BMPR2 LATS1 TEAD2 SMAD2 SMAD4 INHBA SLC2A12 HTT TET1 FOXC2 FOXC1 SNAI1 BMP4 POU5F1 CUL4B PITX2 PAX6 MEIS1 SOX2 FOXA1 ARID5B CCDC6 ACACA BMP7 NFE2L2 FOXA2 LEF1 TCF7L1 HMGA2 ACVR2A WNT3 PRKAR1A WNT3A PPP2CA ZIC2 SOX21 SOX17 CEP250 WDHD1 AXIN1 EMSY AXIN2 WDFY2 HPRT1 BCORL1 TOX CSRP2 NLK MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 FGF8 GDF3 ZFHX4 TRERF1 PBX1 EXT1 FZD4 NODAL FGFR1 TRIM71 PHF6 ZIC3 TRIM5 JARID2 VAV3 NOG PARP8 NR1B3 TOX3 AEBP2 EXT2 AHDC1 ZNF462 ADAM19 ELP4 TWSG1 MSGN1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260211%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF8 MED27 TAF13 TBP H4C9 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP186%HOMO SAPIENS Homologous recombination POLD4 RAD51 RAD54B BRCA2 MRE11A POLD2 ATM RAD52 RPA1 NBN POLD3 RAD50 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP2113%HOMO SAPIENS Type III interferon signaling IF1IB1 TYK2 STAT2 STAT1 IRF9 JAK1 IFNL2 IFNL3 IL10RB IFNLR1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260211%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ND2 ND5 ND4 TIMMDC1 ND6 NDUFB10 TMEM186 C3orf60 TMEM126B DMAC1 NDUFB11 DMAC2 COA1 NDUFAF6 NDUFAF4 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ACAD9 NDUFB9 NDUFB8 NDUFAF1 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 ECSIT NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFA13 NUBPL NDUFAF2 NDUFS3 NDUFA12 NDUFA10 ND1 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260211%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260211%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer TSC2 TSC1 ARAF MAPKAP1 NRAS BRAF PIK3CA AKT3 IRS1 EIF4EBP1 MAPK1 KRAS SOS2 MAPK3 RPTOR MAP2K1 MTOR DEPTOR MAP2K2 PIK3R1 MLST8 PARP2 PARP1 RAF1 RPS6KB1 AKT1S1 INPP4B PTEN RICTOR HRAS GRB2 SOS1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260211%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R5 PIK3CD PIK3R3 PIK3C2G PIK3C2A PIK3C2B PIK3R4 PIK3R2 PIK3R1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260211%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A IL1R1 TGFB1I1 IL1B MAOA ITGB3 TPH2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260211%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum XAB2 POLK XPA GPS1 XPC CUL4A POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 SLX4IP GTF2H5 CUL4B SLX4 ERCC2 MNAT1 RBX1 CHD1L RPA3 RPA1 ERCC1 PCNA CETN2 PARP1 CDK7 HMGN1 H4C9 POLD3 H2AC6 RFC1 POLD4 HIST1H4L DDB2 POLE RAD18 BRCA1 H3F3B LIG1 POLE2 POLD2 POLE3 UVSSA 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MMP23B SMAD2 SMAD4 C1QTNF12 VEGFA COMMD1 PANK4 INTS11 ISG15 INTS13 INTS14 INTS10 GDE1 TMEM52 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK SSU72 TNFRSF14 PEX2 ATAD3C GLTPD1 ACAP3 ELAVL1 RER1 CD160 SCNN1D PEX5 MXRA8 TNFRSF18 VWA1 AURKAIP1 TNLG2A PERM1 KLHL17 PEX12 MEPCE PUSL1 TAS1R3 NADK HES4 MRPL20 OR4F5 DVL1 HES5 OR4F3 CDK11A CFAP74 MIB2 PEX10 RNF223 LRP4 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 TRAF5 INTS9 SLC35E2B C1orf159 PLCH2 PRKCZ TGFB1 CALML6 GRIK2 DKK3 ARF6 TRAF2 TRIM25 TNFRSF4 PARD6B PHKG2 RBX1 VTN GNB1 AGRN MCM2 HEL-S-72p IFIT1 ATAD3A UBE2J2 SKI TNLG2B B3GALT6 INTS4 IFIH1 BTLA DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260211%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MARS1 OMA1 LONP2 TSC2 SESN2 TSC1 GDF15 LONP1 FOXO1 SLC7A7 EIF2A CLPP MYC IRS1 PHB2 MTOR HSPD1 ATF4 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260211%WP5145%HOMO SAPIENS COVID 19 structural coverage map TOMM70 SLC6A19 AQR UPF2 IGHMBP2 GDAP2 NLRP12 UBB MACROD1 HEL97 MACROD2 CMTR1 MAP3K7IP1 NRP1 ISG15 PAIP1 PARP14 UBC PALS1 MACROH2A1 ACE2 MACROH2A2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling ITGB1 PIK3CD MAPK10 EGFR COL1A1 MAPK9 MAPK8 NRAS SRC AKT3 TLN1 MAPK1 MAPK12 KRAS MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RAF1 PXN ITGA1 HRAS GRB2 AREG SOS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260211%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance ERN1 SLC2A4 CD36 PRKCZ PRKAG3 MAPK8 INSR PDX1 RPS6KB1 EIF2AK2 TNFRSF1A INS IRS1 TNF TRAF1 MAFA PPP2CA ACSL1 PIK3R1 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260211%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 NFKB1 IL1B RELA TRAF3 PYCARD NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CCND2 KLF4 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 WNT5B ELAVL1 WIF1 SOST LEF1 CCND3 NKD1 NKD2 DVL1 DVL2 TCF7L2 DVL3 TCF7L1 SOX7 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 MTDH FRAT1 FRAT2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CTBP1 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP4925%HOMO SAPIENS Unfolded protein response ERN1 BCL2 NFE2L2 MBTPS1 BBC3 XBP1 RTCB HEL-S-89n CASP2 MBTPS2 IL1B PMAIP1 DDIT3 TXNIP TNFRSF10B EIF2S1 PPP1R15A BCL2L11 ATF4 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260211%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair PRKDC NASP MDC1 ATM H1-1 RNF168 H4C9 NBN HIST1H4L RAD51 TP53BP1 SETD2 RNF8 SUPT16H XRCC5 SSRP1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260211%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 FADD CASP9 CASP3 BAX TRAF2 BIRC3 RIPK3 TNFRSF1A RIPK1 TRADD TNF CASP8 CYCS MTHFR DEFICIENCY%WIKIPATHWAYS_20260211%WP4288%HOMO SAPIENS MTHFR deficiency MARS1 CASP9 CHKA CASP3 PEMT ASMT CHPT1 GRIN1 EHMT1 ALDH7A1 CHDH DNMT3B HEL-S-61p CYCS 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome ATP2A1 RABEP2 SH2B1 INSR TRAF2 SLN NFATC2IP VAV2 TUFM ATXN2L SPNS1 KDR IFITM1 PLN IL4 SDCCAG8 MPL NFATC2 LAT RAB5A CD81 CD82 CD19 PRMT1 HEL-S-62p CR2 RAB4A TRAF1 GRB2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260211%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMPR2 NOG SMAD6 TOB2 SMAD4 RUNX2 SMURF1 SMAD1 BMP2 TOB1 BMPR1A RANKL RANK SIGNALING%WIKIPATHWAYS_20260211%WP2018%HOMO SAPIENS RANKL RANK signaling MAPK9 PAPSS2 MAPK8 RELA CHUK STAT1 TRAF3 FHL2 RELB TRAF2 GAB2 TRAF6 PLCG1 IKBKG MAP3K7IP1 JUN SRC NFATC1 NFKB1 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 MTOR NFKBIA LYN PIK3R2 SYK PIK3R1 CDC42 TNFSF11 SPI1 TNFRSF11B CBL TNFRSF11A MAP3K7 FOS NFKB2 SQSTM1 IKBKB RAC1 TRAF1 TRAF5 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NFE2L2 MAPK8 NQO1 CEBPB EPHB2 PIK3CA SLC7A11 HMOX1 PRKCA MAF GCLM AIMP2 KEAP1 GCLC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260211%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11B PMP22 FIG4 MPZ MFN2 KIF1B RABAC1 MTMR2 EGR2 RAB7A LRSAM1 RAB4B HSPB8 LITAF GDAP1 SH3TC2 FGD4 RAB25 HEL-S-102 RAB4A RAB11A NEFL SBF2 RAB3B ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR AHCYL2 MTHFD1 SHMT1 HEL-S-51e MTHFD1L TYMS MTHFD2 DHFR MAT1A AMT TCN2 HEL-S-70p CHDH MTFMT GLRX DNMT3B MTHFS FOLH1 HEL-S-61p FTCD NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK1 FLNA MAPK3 PTK2B RPGRIP1L INVS NPHP1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5153%HOMO SAPIENS N glycan biosynthesis DOLPP1 MGAT4B STT3A STT3B ALG1 FUT8 B4GALT1 DPM2 MGAT1 MPDU1 B4GALT2 TUSC3 ALG6 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 RFT1 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B DPM1 RPN2 RPN1 GANAB MAN2A2 MAN2A1 MGAT5B MGAT5 MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260211%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions FOXO6 WWTR1 KNSTRN RAB13 FERMT3 YAP1 FOXO1 FOXP3 RAP1A ARHA STK38L FYB1 MAPK14 MOB1A PRDM1 LPL FOXO4 FOXO3A YWHAQ CD19 CCR7 LATS1 TEAD4 LATS2 RAC1 TEAD2 TEAD3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260211%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK1 TLR4 IRAK4 IRF7 MYD88 TICAM2 RELA CHUK TRAF3 RELB TIRAP TRAF6 TBK1 IKBKG NFKB1 TLR5 MAPK1 TLR9 TLR7 IKBKE TLR1 TICAM1 NFKB2 IKBKB REL IRF3 TLR8 TLR3 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling TLR4 TIFA IRF7 CISH TREM1 SOCS1 CCL5 RBCK1 CCL4 NFKBIA PTPN6 MLST8 IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B MAP3K7 IL12A PIK3R3 SQSTM1 MBL2 MAPK10 MAPK9 MAPK8 SFTPA2 LBP CYLD TLR5 CXCL8 CASP8 SPP1 ZMYND11 PIK3R2 SYK PIK3R1 PLK1 IRAK3 PELI1 SMAD6 FADD IKBKB RAC1 CXCL11 IRF3 CD14 TLR8 TLR3 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 FBXW5 LY96 IFNA21 TRAF3 CD180 IF1AA9 TRAFD1 TIRAP SIGIRR CUEDC2 SFTPD MAP3K7IP1 RNF31 PELI3 SARM1 TNFAIP3 IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RIPK1 IFNA7 TICAM1 NFKB2 BTK IRAK1 IRAK2 PIK3CD IRAK4 TAB3 MYD88 OTUD5 CHUK TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 IFNA2 TLR9 TLR7 TMED7 PIK3R5 RNF41 FOS IFNB1 IL1B CXCL9 IFNA1 CCL3 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP530%HOMO SAPIENS Cytokines and inflammatory response IL15 TGFB1 CSF3 CXCL2 PDGFA IL10 IL13 HLA-DRB1 IL2 IL4 IL6 IL5 IL7 CSF1 IL11 TNF HLA-DRA IL3 IL12B IFNB1 IFNG IL1B CSF2 CXCL1 IL1A PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP183%HOMO SAPIENS Proteasome degradation PSMC4 PSMA4 PSMA2 PSMC1 PSMB6 PSMB2 PSMB3 NEDD4 UBE2D1 PSMD9 PSMB10 HLA-A UBE2B HEL-S-276 PSMD6 PSMB8 HLA-B HEL-S-283 PSMD7 HLA-F PSME2 HLA-G HLA-C HLA-E PSMD4 PSMD5 PSMD2 UBE2D3 PSMD3 PSMD1 UBE2D2 H2AX UBB HIST1H2AB H2AZ1 PSMD10 UBA7 PSMD12 PSMD11 HEL-117 HEL-S-91n PSMD13 RPN2 UBC RPN1 IFNG PSMC6 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260211%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA NR1i1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways MEF2C CREBBP EP300 CTCF ASCL1 CAV3 CEBPB SCN3B NKX2-2 BDNF GATA3 SNTA1 GATA2 SCN4B HDAC9 NKX3-1 YBX1 TLX3 POU3F2 PHOX2B C4B_2 SST POU2F2 C4A IL6R TCF3 DLX2 HIF1A G6PC1 GCK TF RORA MAP2 PAH IL10 HEL-S-162eP IL13 CXCL8 CHRNB2 CPT1A ECE1 EN1 BHLHB2 CREM PPARGC1A IL1RN EGR1 FREP1 IL1A AQP4 TACR1 SLC9A3 FOXM1 VEGFA TPH2 POU5F1 TPH1 ChAT GRIN1 FEV CTNNB1 PKNOX1 TNF TSPYL1 CHRNB4 DEAF1 SPTBN1 PHOX2A SOX2 MYB NR3A2 CC2D1A HEL2 NOS1AP KCNJ8 GPD1L HEL-S-125m LMX1B AVP CHRNA7 PPARGC1B HADHB 5HT1A GJA1 NR3C1 HDAC1 NEUROD1 HES1 NFYA HES5 NFKB2 PRKAR1B PRKAR1A REST SP3 RET ACADM CHRM2 SCN5A TP73 CASP3 HTR2A JUN NFKB1 SLC25A4 IL6 NTRK2 SP1 DDC NR1A2 MAOA HEL-S-87p ADCYAP1R1 VIPR2 GNB3 SNAP25 PBX1 SSTR2 RYR2 SLC1A3 YWHAQ TH HEL-S-1 YWHAG YWHAZ NGF CREB1 RUNX3 IL1B HSPD1 VAMP2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C8 CYP2C19 CYP2C9 CYP2B6 CYP2C18 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 TMEM120B MDH2 TMEM120A SSC4D POR RAF1 STYXL1 HEL163 PTPMT1 KIF1C SFN EPB41L3 YWHAG LMNA RHBDD2 ZP3 ZP2 HEL-S-102 DAPK2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260211%WP585%HOMO SAPIENS Interferon type I signaling STAT2 STAT1 MAPKAP1 GAB2 MAP3K1 VAV1 ZAP70 TYK2 SOCS3 SOCS1 IRS1 MAP2K3 EIF4EBP1 PTPRC FYN MAP2K6 RPTOR PTPN11 MAPK14 PTPN6 MLST8 EIF4E EIF4B RPS6KA4 RPS6 IRF9 RPS6KA5 RPS6KB1 PRMT1 REL LCK PIK3CD STAT3 STAT4 IFNAR2 CRK PIAS1 IFNAR1 RAP1A CRKL MTOR PIK3R2 PIK3R1 EIF4A1 RAPGEF1 CBL CREB1 RAC1 JAK1 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260211%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD AGPS LPIN1 IPMK LPIN2 PIK3CA HMFN0839 PLA2G2A PI4K2A PTDSS1 CHKB PCYT2 PTPMT1 GPAM PEMT MOGAT3 GPD1 CHPT1 PGS1 CEPT1 CRLS1 GPAT2 GPAT4 CDS2 PIP5K1A GNPAT CDIPT RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260211%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA CMKLR1 PIK3CD FPR2 EPHB2 MTOR GRK1 LTB4R HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 CD36 HIF1A HEL-S-133P PPARG GPD1 HEL-S-49 HEL-S-162eP NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 RRM2 POLA1 MTHFD2 OAZ1 DHFR HPRT1 POLG RRM2B ADSL NME2 SRM IMPDH1 ADSS FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF9 MAPK9 FABP4 CEBPA KLF5 INS PIK3CA GATA3 GATA2 PLIN1 NR1C1 MGLL KLF2 LMNB2 PNPLA2 PPARG LPL LIPE ZMPSTE24 FNTA BANF1 LMNA CIDEC ICMT PRRX1 STAT5B CIDEA SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260211%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 SLC6A19 FURIN ACAT1 CTSL TMPRSS4 ACE2 NRP1 TLR7 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP1 AGPS LPL GPAM MOGAT3 GPD1 LIPF LIPE AGPAT4 AGPAT5 MOGAT2 MOGAT1 AGPAT3 DGAT1 GNPAT LIPC DGAT2 PLPP3 PNPLA2 PLPP2 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260211%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IRAK1 TIFA UBE2V1 NFKB1 SQSTM1 PRKCZ HEL-S-71 TRAF6 IL1A AJUBA SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260211%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RAF1 RASGRF1 HTR2B NRAS HTR2A GATA4 MAPK1 KRAS MAPK3 HRAS MAP2K1 MAP2K2 MAPKAPK2 MAPK CASCADE%WIKIPATHWAYS_20260211%WP422%HOMO SAPIENS MAPK cascade MAPK10 MAP2 ARAF MBP NRAS BRAF MAP3K1 MAP3K2 JUN LAMTOR3 RRAS MAP2K3 MAPK1 MAP2K4 MAPK12 KRAS SOS2 MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 RASA3 RAF1 SIPA1 PLCB3 HRAS GRB2 MAP3K12 SOS1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260211%WP3287%HOMO SAPIENS Overview of nanoparticle effects BCL2 PIK3CD PTGS2 BAX CRP CCND3 COL4A1 HMOX1 PTGS1 IL6 NFRKB AKT3 CXCL8 TNF LAMA3 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260211%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing OAS1 TREX1 RNASEL ADAR RNASEH2C IFNB1 RNASEH2B RNASEH2A MAVS RNASET2 CGAS RIGI MITA IFIH1 IRF3 CILIOPATHIES%WIKIPATHWAYS_20260211%WP4803%HOMO SAPIENS Ciliopathies USP9X ADCY6 XPNPEP3 DYNC2I2 CEP19 INVS NPHP3 DYNC2H1 DYNLT2B SUFU DYNC2LI1 KIF7 OCRL RP1L1 IFT172 PKD1 DNAJB13 PIK3R4 RSPH9 SMO AHI-1 IFT81 TCTN3 CENPF GPR161 TCTN2 INTU TCTN1 RSPH3 ALMS1 HEL-S-296 IFT27 CC2D2A RPGRIP1L RSPH1 TMEM138 SPAG1 NPHP1 TULP1 PIBF1 CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 C2CD3 B9D1 RAB23 B9D2 CCDC41 KIAA0753 CCDC40 OFD1 ANKS3 BBIP1 PDE6D NEK9 PLK4 ZNF423 CRX TRAF3IP1 CEP164 FLCN IFT52 TMEM107 ODAD1 CNGA1 ODAD3 NEK1 ODAD4 BBS9 CCDC28B BBS7 MCIDAS IFT57 NME7 TBC1D32 BBS5 NEK2 CEP290 DNAAF3 DNAAF2 ZIC2 BBS4 DNAAF6 IQCB1 CFAP418 FAM161A CCNQ IFT140 IFT80 CCNO CFAP410 AK7 CEP78 WDR35 LZTFL1 DNAAF19 ARL2BP EVC DNAL1 BBS10 DNAAF11 IFT43 HYDIN BBS12 CCDC39 RP2 MAK CFAP52 DNAI2 TMEM216 TOPORS EFHC1 WDPCP RP1 NME9 WDR51B CNGB1 ZMYND10 SDCCAG8 CEP104 KIZ ARL6 CFAP53 ARL3 KATNIP DNAH6 PKD1L1 PKHD1 CFAP298 ARL13B POC1A TMEM67 RAB28 INPP5E DNAI1 EVC2 TUB BBS2 DYX1C1 NEK8 RPGRIP1 BBS1 TTLL5 PCARE HYLS1 SCLT1 ATXN10 DCDC2 TTC8 MKS1 CEP41 TRIM32 GLI3 CLUAP1 DRC1 CHOLESTASIS%WIKIPATHWAYS_20260211%WP5238%HOMO SAPIENS Cholestasis SCARB1 NR1H4 LDLR SLC22A1 ABCC2 ABCB4 SLCO1A2 HMGCR ABCC3 ABCB11 EPHX1 RXRA NR1I3 ABCG8 ABCG5 ATP8B1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260211%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A22 GOT2 SLC25A12 GLUD1 SLC25A13 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260211%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYP11A1 SRD5A2 POR HSD17B6 STAR AKR1C4 AKR1C2 HSD17B3 CYP17A1 HSD3B2 FOLATE METABOLISM%WIKIPATHWAYS_20260211%WP176%HOMO SAPIENS Folate metabolism RELA INSR CRP FLAD1 DHFR INS CSF1 TNF GPX1 CCL2 HEL-S-44 SCARB1 APOB SERPINA3 LDLR SLC19A1 MTRR SAA4 HBB MTR PLAT FOLR1 PLG HEL-S-51e MPO MTHFD2 ABCA1 FGA HBA2 GPX6 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG ALB SAA1 SAA2 GPX4 GPX2 CBS NFKB1 IL2 IL4 IL6 CTH MTHFS SLC46A1 IZUMO1R FOLR3 MTHFD1 FOLR2 GPX3 SHMT1 IL1B INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB1 PAK1 ARHGEF7 VASP CAV3 BRAF VAV2 CAPN3 DOCK1 SRC SHC1 ZYX PDPK1 AKT3 MAP2K3 MAPK1 MAPK12 FYN MAP2K6 MYLK2 MAP2K1 SHC3 MAP2K2 HEL-S-28 RAF1 HEL114 ITGB3 ITGA2B RAC3 PXN CAPN10 ITGA1 PAK6 SELENOP PAK4 ITGA2 ITGA4 MAPK10 ITGB7 MAP2K5 ARAF RHO CRK ROCK1 CAPNS1 ROCK2 MAPK7 RAP1A CAV2 TLN1 PIK3R2 CDC42 RAPGEF1 MYPN ITGAM ITGB5 ITGB4 CAPN9 CAPN6 ITGAE CAPN7 CAPN5 ITGB8 TNS1 ITGAV GIT2 ITGAX ITGB6 CAPN11 VAV3 MAPK6 ITGA7 ITGA6 MAPK4 RAC1 HRAS CSK GRB2 SOS1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260211%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B HIST1H4L H2BC12 CHAF1A RBBP4 HIRA H4C9 SMIM40 IL18 SIGNALING%WIKIPATHWAYS_20260211%WP4754%HOMO SAPIENS IL18 signaling TICAM2 RELA CEBPB FAS CTNNB1 CSN2 MAPK1 TNF MAPK3 IL18R1 NFATC4 NFKBIA ELAVL1 IL37 PRKAA1 TNFSF6 NCF1 RPS6KB1 PRKCB MAP3K7 IRF1 PRKCA ACACB HEL-S-102 LCK CYCS GSK3B IRAK1 MAPK9 MYD88 CASP3 CHUK IL18RAP BAX TRAF6 TNFRSF1A GATA1 NFKB1 SP1 CASP8 PIK3R1 PARP1 NCF2 IMP3 SLC12A3 GRIN2B PTEN IL18 IKBKB NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260211%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium GSK3B MAP1B MEF2C GHRL NGFR APP ID2 ASCL1 MAP2 STAT3 CXCL12 MRE11A ID1 BDNF KDM1A PLXND1 CDK5R1 MYC NTRK2 PAX6 NRG1 ERBB4 DAB1 AGRN SOX2 DISC1 NUMB NOTCH1 PSEN1 PAFAH1B1 NEUROD1 RTN4 NDEL1 HES1 TCF4 LRP8 NTRK1 TCF3 NEUROG3 FAIM NTRK3 NGF RELN VLDLR CDK5 IL17A RET RTN4R CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260211%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K1 IGF1 TGFBR1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 NFATC2 MAP2K1 MAPK14 MAP2K2 CDK9 EGF RAF1 IKBKE FGFR2 MAP3K7 PRKCA PRKD1 GSK3B MAP2K5 MAP4K1 MAPK8 TGFB1 CHUK IKBKG TNFRSF1A MAPK7 NFKB1 MAP3K14 MTOR CALM1 CDK7 FGF2 NPPA GUCA1A IKBKB PPP3CA RAC1 CAMK2D 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome METTL27 STX1A FKBP6 VPS28 ATPAF1 TRIM50 HDAC2 FBLN2 ATP8 FBLN5 ATP6 MVB12A CLASP2 ATP5MC2 TMEM270 TBL2 ATP5MC3 GTF2IRD1 FAS CTNNB1 CLDN1 MYC ATP5G1 PRKG1 NRG1 HDAC6 MAPK3 ABHD11 TSG101 ACACA MLXIPL H2AX USF1 HEL-S-123m FBN1 EIF4H ATP5PB EIF2A ATP5F1D GTF2I ATP5F1E SQSTM1 ACACB ATP5PO RB1 BTK SF3B1 ATF4 MYBBP1A HEL-S-15 HMGA1 RFC2 CHTF18 CLDN3 UBE2L6 CDKN1C HEL-S-162eP MYO1C CLASP1 DLD LIMK1 GRIP1 ULK1 SNAP25 CLDN5 CLTC PCNA CLDN4 BRD4 LAT2 PKLR NUP62 DDX21 UBIAD1 FZD9 OGDH BAZ1B BCL7B BUD23 VPS9D1 HDAC3 ATPAF2 UBE2E3 SMARCA5 VPS37C HSPA2 DEK HEL-S-271 UBE2E1 VPS37D GRB2 VPS37A HOXC8 VPS37B CLIP2 VAMP2 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260211%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCB4 TLR4 CAMK2A PLCB1 PLCB2 STAT2 STAT1 IFI44L NRAS IFI27L2 CAMK2G RSAD2 TYK2 ISG15 CYP27B1 RXRA MAPK1 TNF NR1i1 MAPK12 KRAS MAPK3 MAPK13 CCL2 MAPK11 MAPK14 CAMP OAS2 DEFB4B CD40 PRKCH IFNGR2 PRKCB PRKCE PRKCA NFKB2 CD40LG IFNG PRKCQ SP3 RXRB NOD2 PRKCZ MAPK9 RXRG CYP24A1 MAPK8 RELB PLCG2 IFNAR2 IFNGR1 JUN TNFRSF1A MAPK7 NFKB1 IL6 SP1 CXCL8 IFNA2 PLCE1 PLCB3 IKBKB JAK1 HRAS CAMK2D TLR8 MED1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17RC IL17RA IL17A SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260211%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKB1 HMGB1 IKBKB THBD CHUK RELA NFKBIA IKBKG AGER MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP391%HOMO SAPIENS Mitochondrial gene expression GABPB1 TFAM PPARGC1B MYEF2 HCFC1 POLRMT GABPA MTERF3 MTERF1 NRF1 SP1 CREB1 PPP3CA PPARGC1A TFB1M TFB2M PPRC1 ESRRA CAMK4 DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20260211%WP4946%HOMO SAPIENS DNA repair pathways full network RAD54B SMUG1 REV3L ERCC2 POLI FANCD2 FAN1 H2AX FEN1 MPG PNKP OGG1 NBN UNG RFC1 POLD3 POLD4 NTHL1 DDB2 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 NEIL2 APEX1 POLE3 RAD52 CHEK1 WDR48 XPA XPC CUL4A ERCC5 RFC2 GTF2H2C_2 CCNH MSH6 GTF2H2 FAAP24 GTF2H3 MSH2 BRIP1 GTF2H5 FANCM MNAT1 CENPX RAP1A FANCL REV1 WRN FANCA POLM NHEJ1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C PARP2 ERCC1 CENPS CETN2 CDK7 ATM ATR BRCA1 BRCA2 POLD2 XRCC5 TDG POLE4 MRE11A MSH3 DDB1 RAD50 CUL4B RAD51 HMGB1 RPA3 RPA1 MGMT POLK RFC3 RFC4 RBX1 PRKDC PCNA PARP1 TERF2 PMS2 USP1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260211%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TAF5 MED23 TAF8 MED27 MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 MED30 MED31 POLR2M POLR2L TAF10 TAF11 MED14 TRFP CRSP9 TAF1 TAF4 TAF3 POLR2A THRA CDK8 POLR2D GTF2B TAF9 CTDP1 GTF2E2 POLR2B POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K TAF13 MED15 TAF7 TAF6 TBP CCNC TAF12 MED9 NELFB NELFCD NELFA POLR2C MED1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260211%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway HTR1D HTR1B HTR1F GNAI1 STAT3 BRAF HTR2A MAP3K1 GNAI3 PIK3CA MAPKAPK3 PDPK1 RAP1A MAP2K3 MAPK1 ARHA MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 GNAO1 5HT1A RASGRF1 RPS6KA5 FOS CREB1 MAPKAPK2 HTR1E GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260211%WP4157%HOMO SAPIENS GABA metabolism aka GHB HEL-S-166mP ADHFE1 GLS ALDH5A1 GAD2 GLS2 GAD1 PON3 ABAT NAD METABOLISM%WIKIPATHWAYS_20260211%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 PARP1 NAMPT SIRT1 SIRT3 SIRT6 NADK NRK SIRT4 NT5E SIRT5 SIRT7 NMNAT3 NMNAT2 SIRT2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH GCK UXS1 PGM3 HK3 HK2 GFPT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260211%WP1531%HOMO SAPIENS Vitamin D metabolism RXRB GC CYP27B1 CYP24A1 RXRA DHCR7 NR1i1 PTH CYP27A1 CYP2R1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260211%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADRA1D ADORA2A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260211%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH RAF1 PRKAA1 NFKB1 PRKCA DUOX1 RAP1A CLCN5 CREB1 HEL-S-5 PRKAA2 SLC5A5 MAPK1 DUOX2 MAPK3 TSHR MAP2K1 TG MAP2K2 CGA TPO NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 IL6R IL6 SOX4 IL11 STAT3 RELA IL11RA JAK1 JAK3 IL6ST PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 PTGER1 PTGER3 PRL PTGS2 ANXA6 EDNRA AKR1C1 AKR1C2 S100A6 SOX9 EDNRB CYP11A1 ANXA2 PPARGC1B PPARG PTGFR HPGD AKR1B1 EDN1 PTGS1 HEL-S-7 TBXA2R PTGDR PTGIR PTGIS PTGFRN PPARGC1A ANXA3 PTGER4 ANXA4 ANXA1 SCGB1A1 PTGER2 S100A10 PTGES ZINC HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A8 SLC30A2 SLC30A5 SLC39A14 SLC30A4 SLC30A1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC39A8 MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260211%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACSL3 HSD17B10 EHHADH ACADSB ACADL DECR1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 ALOX15 EPHX2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260211%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling ADCY3 PLCB1 MYL12B GNG2 STAT1 BRAF IGF1R SRC PDPK1 CDK4 MAP2K3 CDK2 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 RAF1 CDKN1B RPS6 CCND3 RPS6KB1 RBL2 RB1 APEX1 KCNIP3 GNAI1 STAT3 TSHB RAP1GAP SCRIB GNAI3 PIK3CA RAP1A GNB1 GNAS TSHR MTOR CGA GNAO1 PIK3R2 PIK3R1 CCNE1 RPS6KA1 PDE4D GNA13 CREB1 JAK1 HRAS PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NOTCH1 RBPJL CTNNB1 FGF10 PTF1A PDX1 RBPJ KAT2B PROX1 NKX6-1 HES1 MALE INFERTILITY%WIKIPATHWAYS_20260211%WP4673%HOMO SAPIENS Male infertility MMP9 SRD5A2 CREBBP SIRPA EP300 CHD2 SOX5 TRIP13 ERCC2 CYP26B1 HLA-DRA PON2 CDK9 PON1 APOB TMEM132E CYP17A1 RFC1 PEX10 AHR HMGA1 XPC CCNK PRDM9 REC8 SIRPG EPSTI1 RAG1 NANOS1 PRM2 PRM3 SPATA17 TSSK4 DDX4 DAZ4 THBS1 DAZ3 VCX DAZ2 CLU MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 FOLH1 PIWIL4 GNAO1 SPO11 XRCC3 HORMAD2 MSMB ERCC1 PRMT6 PACRG TEX15 CXXC1 ABLIM1 OR2W3 P1 USP26 NQO1 CDC42BPA MDM2 MLH3 ATM CTCFL ABCB1 SEMG1 CYP1A1 BRDT BRCA2 MMP2 DND1 FAT10 XRCC5 INSR PSAT1 KDM3A FAS AHRR UBE2B TNF MAS1L GPX1 NR3A2 BCL2 MTRR SLC16A7 NFE2L2 MTR TNFSF6 TCN2 MSH4 HEL-S-61p AGO2 STRA8 POLG HEL110 NOS2 PARP1 SLC46A1 PEMT MTHFD1 SHMT1 H4C9 DAZL PMS2 H3-4 ETV5 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260211%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease ANGPT2 SMAD2 LTBP1 SMAD4 MAPK8 NR2C2 RUNX2 FBN1 TGFBR3 CTGF FBN2 TGFBR1 FBN3 LTBP2 SHC1 MAPK1 FLNA ENG MAPK3 POSTN MAPK14 TGFBR2 AGTR1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260211%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 CS SDHC SDHD SDHB SDHA OGDH ACO2 IDH3B FH SUCLA2 DLD SUCLG2 SUCLG1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260211%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR FURIN ACE2 VEGFA NRP1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260211%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 HSD11B2 EBP SLC27A5 THEM5 DHCR7 ACOT8 ACOT7 ACOT11 ACOT12 BAAT ACOT13 ACOT9 AMACR ACOT6 SLC27A2 NPC1 ACOT4 DBP CYP7A1 EPHX2 CYP27A1 NPC2 AGE RAGE PATHWAY%WIKIPATHWAYS_20260211%WP2324%HOMO SAPIENS AGE RAGE pathway MMP9 EGFR SMAD2 RELA STAT1 INSR TIRAP INHBB FOXO1 SRC INS SHC1 IRS1 MAPK1 MAPK3 ATF2 HEL-S-44 MAP2K1 MAPK14 NFKBIA RAF1 ALPL NCF1 AGER PRKCB PRKCA HIF1A STAT5B EZR CYCS IRAK4 CASP9 PRKCZ MAPK9 MAPK8 MYD88 CASP3 CHUK STAT3 ROCK1 JUN NFKB1 SP1 CASP8 ARHA NOS2 CDC42 FOXO4 DDOST HEL70 MSR1 MMP7 IKBKB MMP2 RAC1 MMP14 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260211%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i2 NR1H4 ABCC2 SLC51A SLC51B SULT2A1 ABCB1 BAAT ABCC3 SLCO1B1 ABCB11 CYP3A4 NR1I3 NR1i1 CYP7A1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260211%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance BCL2L1 CDKN1A HIF1A ABCB1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2276%HOMO SAPIENS Glial cell differentiation HEL70 CNP MBP GAP43 FREP1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome NKX2-5 CDC45 CYP26A1 HIRA HIRIP3 PAX3 CYP26B1 GBX2 HEL25 SLC2A4 CYP26C1 FGFR2 SREBF2 TBX1 GSC2 HAND2 PAK4 CDH15 ACTA2 RORC CLDN3 PARK2 SLC25A1 HEL-S-80p DGCR8 DROSHA CRKL GP9 SNAP29 PLK1 SERPIND1 SEPT5 TXNRD2 TSKS ZDHHC8 RCC1 C22orf39 DRD2 THAP7 TSSK2 RTL10 HDAC3 NPRL2 TRMT2A ESS2 KLHL22 GP5 LRRC74B SEPT8 MRPL40 DGCR6L GP1BA TNPO1 ASF1A SCARF2 EGFR DGCR2 GP1BB C16orf35 SLC7A4 GNB1L DEPDC5 FOXC2 CCDC188 FOXC1 ARVCF RANBP1 P2RX6 SHH ZNF74 PITX2 FGF10 CLDN1 NCOR1 BCL2 RAF1 FOXA2 RTN4 HES1 ALDH1A2 EMC10 POLR2A RELN RTN4R RBX1 MED15 FGF8 CLDN5 CDC42 UFD1L FGFR1 GLUD1 H4C9 CLTCL1 VWF RAN SHOC2 PRODH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP138%HOMO SAPIENS Androgen receptor signaling EGFR CREBBP STUB1 SMAD4 EP300 RUNX2 RELA FHL2 FOXO1 EFCAB6 HEL32 SRC KAT7 KDM1A PIAS2 CTNNB1 ZNF318 FKBP4 RNF6 RNF4 TGFB1I1 BAG1 FLNA PATZ1 NCOR1 SMIM40 UBE2I SUMO1 SIRT1 HDAC1 TGIF1 RB1 PAK6 KAT2B CCND1 ZMIZ1 GSK3B RAD9A STAT3 TLE5 PIAS1 ROCK1 KAT5 ROCK2 UBE3A JUN HEL-S-99n PSMC3IP SP1 ARHA RLN1 PIK3R2 NCOR2 PIK3R1 CDC42 NR2C2 RHOB MDM2 CCNE1 HEL-S-67p NR0B2 PTEN BRCA1 CREB1 RAC1 RAN SIN3A CARM1 LIMK2 NCOA1 SMARCE1 ETV5 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260211%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome CFD HEL-S-62p ICMT LMNB2 RCE1 FNTA LMNA CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 MDH2 ALDH7A1 HEL-S-5 GCDH L2HGDH D2HGDH APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260211%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein GSK3B BCL2L1 BCL2 BCL2L2 BAK1 ITGB4 BAX BOK PTHLH GSK3A MYC AKT3 BCL2A1 BCL2L10 ITGA6 BCL2L12 BCL2L14 MCL1 BCL2L13 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260211%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP550%HOMO SAPIENS Biogenic amine synthesis GAD2 PAH GAD1 ASMT TH TPH1 ChAT AANAT DDC ACHE MAOA HDC PNMT DBH LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260211%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 TRIM71 EGR1 SOX2 POU5F1 AXON GUIDANCE%WIKIPATHWAYS_20260211%WP5289%HOMO SAPIENS Axon guidance ITGB1 MYL12B DCC SLIT1 SHH SLIT3 TRPC1 SRC PDPK1 MAPK1 MET FYN RYK gdf7 SEMA5B RHOD ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 RAF1 ABLIM3 ROBO2 LRIG2 CXCR4 SRGAP2 NTNG2 NGL1 SLIT2 EPHA2 PRKCA WNT4 NTN3 PARD3 CDK5 ARHGEF12 GSK3B RGMA HEL-S-15 PRKCZ EPHB1 GNAI1 CXCL12 ROCK1 NRP1 PARD6A RRAS PLXNA1 PTCH1 EFNA1 CDC42 SEMA3A BOC L1CAM FES FZD3 ROBO1 NCK1 BMPR2 RAC1 HRAS CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway NCOA6 ABCC2 DNAJC7 SULT1A1 FOXO1 UGT1A4 CYP2C19 SP1 CYP3A4 RXRA NR1I3 UGT1A3 CYP2C9 CYP2A6 CYP2B6 SULT2A1 UGT1A1 EHHADH ABCB1 UGT1A9 ABCC3 SMC1A PTPA PPARGC1A CYP4A11 ALAS1 NCOA1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260211%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 OAS1 STAT1 IFI35 IRF9 IFIT3 IFNAR2 PIAS1 IFNGR1 IFNGR2 TYK2 IFIT1 IRF1 IFNAR1 IFITM1 PSMB8 SOCS1 IFNG JAK1 MX1 TAP1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260211%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 EGFR FST SMAD4 KRTAP8-1 BMP6 IGF1 MSX2 EGR2 BMP4 SFRP1 CD200 PERP GATA3 CTNNB1 CD34 CASP14 MSX1 SOX2 SOSTDC1 TP63 NOTCH2 ADAM17 NOTCH1 ZBTB16 WIF1 NR3C1 LEF1 HR Nbla10317 ATL1 HOXC12 KRTAP3-3 PHLDA1 IGFBP5 KRTAP15-1 SPINK6 SPINK5 TCF4 ADAMTS20 DSG1 TCF3 DSG4 IFNG GPR49 DLX3 KLK5 KLK4 GPRC5D LRIG1 KRTAP6-1 FOXE1 KRTAP2-4 GSDMA KLK13 KLK14 FOXN1 GTPBP4 KRT19 GJB6 KITLG GAS1 DKK3 FOXQ1 CTGF JUN NFATC1 NFKB1 DKK1 DKK4 RBPJ SMAD1 ELANE SOX9 DSC2 FZD1 BMPR1A FOS S100A4 RUNX3 KLK6 CD133 FOSB ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260211%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1A2 RELA CHUK GUCY1B1 IKBKG TMPRSS2 HMOX1 NFKB1 IL6 CXCL8 RXRA TNF CCL2 ACE2 GCLM NFKBIA GCLC NFE2L2 NQO1 SLC7A11 IL12A IKBKB IL1B MMP3 IRF3 KEAP1 GLUCURONIDATION%WIKIPATHWAYS_20260211%WP698%HOMO SAPIENS Glucuronidation UGDH UGT2B10 UGT2B4 PGM2 UGT1A8 PGM5 UGT2B7 UGT1A3 UGT1A10 UGT1A1 UGT2B28 UGT1A9 UGT1A5 UGT2B11 UGT1A4 UGT2B15 UGT2B17 UGT1A7 UGT2A2 PGM3 UGT2A1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260211%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC19A1 SLC46A1 MTR FOLR1 MTHFD1 MTHFD2L SHMT1 HEL-S-51e TYMS MTHFD2 DHFR HEL-S-70p MTHFS FTCD IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260211%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF LYRM4 HSCB ABCB7 FDX1 NFU1 FDXR CIAO2B FXN ISCU NUBP1 NUBP2 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF EGFR RAF1 CASP3 HTT RPS6KA5 BDNF NTRK2 CREB1 MAPK1 MAPK3 HRAS MAP2K1 MAP2K2 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260211%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells CCND2 PRL EPOR STAT1 STAT3 EPO CISH NRAS PRLR FOXM1 IFNGR1 SOCS2 CDK4 SOCS3 IL6 SOCS1 AKT3 KRAS RPTOR GHR MTOR MLST8 GH1 CCND3 IFNGR2 AKT1S1 IL6R IFNG STAT5B HRAS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260211%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH ME1 BRAF HEL-S-32 PDP2 ME2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2879%HOMO SAPIENS Farnesoid X receptor pathway NR1H4 UGT2B4 CYP8B1 SLC27A5 ABCB4 SULT2A1 NR0B2 SLCO2B1 BAAT ABCB11 FGF8A FKBP5 CYP3A4 RXRA PPARGC1A IP6K3 CYP7A1 NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP4919%HOMO SAPIENS Neuroinflammation TLR4 COX1 MAPK8 CHUK RELA JUN ASCC1 FOS NOS2 MAPK14 MTOR NFKBIA COX2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260211%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CREB1 MTR ADH5 CEBPB CBS CYP2E1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260211%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ASS1 ARG2 GLUD1 ARG1 ALDH18A1 SMS OTC HEL-S-29 HEL-S-5 SRM HEL-S-20 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260211%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NDUFB10 NDUFB11 CEBPA COX7A2 NDUFV3 NDUFV2 SOCS3 NDUFC2 NDUFC1 PRKAA2 NDUFS6 NDUFS5 NDUFS4 CCL2 NDUFS1 COX2 NDUFB9 BCL2L11 NDUFB8 PRKAG1 NDUFB7 PRKAG2 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 PRKAG3 NDUFB1 BBC3 NDUFA7 LEPR NDUFA6 PRKAB2 NDUFA5 ZNF183 NDUFA3 PRKAB1 NDUFA2 IL6R PIK3R3 ADIPOR1 NDUFAB1 ADIPOR2 VCAM1 MAPK9 MAPK8 TGFB1 BAX COX7B COX4I1 COXFA4L2 COX6A1 CXCL8 DDIT3 CASP8 COX8A PIK3R2 COX6B1 PIK3R1 COX7A1 SDHC XBP1 SDHD UQCRB SDHB COX3 CYP2E1 UQCR11 UQCR10 GSK3A CYB UQCRH UQCRQ UQCRC1 IKBKB UQCRFS1 CYC1 RAC1 UQCRC2 IL1A BAK1 INSR RELA INS FAS NR1C1 AKT3 IRS1 RXRA TNF MAP3K5 MAP3K11 ERN1 NR1H4 MLXIPL PRKAA1 TNFSF6 COX4I2 NR1H3 EIF2S1 CYCS ATF4 GSK3B LEP COX1 PIK3CD CASP3 TRAF2 SDHA JUN TNFRSF1A NDUFC2-KCTD14 PIK3CA COX6B2 NFKB1 COX7B2 MLX IL6 COX8C MLXIP UQCRHL NDUFA13 CDC42 PKLR COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 IL1B NDUFA9 NDUFA12 NDUFA10 COX6A2 ITCH COX7A2L SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260211%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B2 SLCO4C1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 NR3A2 SULT1E1 HSD17B1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 B3GALT2 B3GALT1 FUT3 FUT1 FUT2 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260211%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin ANGPT2 ANGPT1 VEGFA GATA2 CX3CL1 CCL8 CCL5 MAP2K4 HLA-G CCL7 TNF MAPK3 CCL2 IL15RA CCL4 MAPK11 NR3A2 BCL2 PGR CXCR4 NR3C1 IFNG STAT5B JAK3 MCL1 VCAM1 IL2RB ITGA4 IL15 IL2RG CXCL12 IL10 IL4 IL6 CXCL8 GAB3 NCR2 MADCAM1 KIR2DL4 IL3 SELL CD69 PIBF1 JAK1 CXCR3 CXCL11 NCR1 NCR3 CCL3 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260211%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 CHDH SLC44A1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260211%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ITGB1 CLDN4 ZEB2 TGFB1 ALPL SFRP1 TERT MYC ITGA6 TNF NRG3 ERBB4 CCND1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260211%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRAK1 TLR4 IRAK4 IRF7 MYD88 CHUK TRAF3 TIRAP TRAF6 TBK1 IKBKG MAP3K7IP1 TRAM1 NFKB1 IL6 CXCL8 TNF INPP5D NFKBIA IRAK3 IKBKE RIPK1 MAP3K7 TICAM1 IFNB1 IKBKB IRF3 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260211%WP2006%HOMO SAPIENS miR targeted genes in squamous cell AP3D1 ARCN1 SPCS3 NEDD4 LAMTOR5 HEL-S-30 MET POGLUT3 AXL TPM3 TPM1 GYS1 RAB34 TMEM59 MAP3K8 NCL PTMAP7 RHEB LAMC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 SDCBP GAS2L1 TNFRSF10B VCAM1 HMGA1 SLC4A10 NF2 TBCA CHMP2A SRPRB DKFZp761E1322 PICALM THBS1 ADAR SYNE2 TUBA1A FBXW11 SMAD1 CTDSP1 SIGMAR1 SEC23A HSD17B12 UBE2J1 DNAJB1 POLR2C SPTLC1 POLD2 TGFBR2 SH3BP4 ATP6V1C1 ATP6V1F GFPT1 PDLIM7 SLC12A2 GALNT7 GALNT1 ATP6V0E1 FMNL2 CPNE8 VEZT CUL4B BET1 PWP1 PNP DHX57 CIAO2A GOLGA7 FNDC3B FNDC3A PISD RTN4 POM121 HES1 MRPL20 COMMD9 SLC38A1 PEDS1-UBE2V1 MOV10 RARS1 ANP32B RNP24 NRP1 HEL-S-26 ARF4 TRAM1 HMOX1 MAGT1 MRC2 TMEM43 HOXA7 SH3BGRL3 TMED7 ANXA2 E2F3 ATP2A2 ELOVL5 AP2A1 PRPF40A YWHAQ CSDE1 FGF2 P4HA2 PXDN MRPS33 AKAP8 PPP1R7 MPZL1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MCAT HSD17B12 ACACA MECR OXSM HTD2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-117 ADH6 ALDH2 HEL-S-53e HEL-S-4 CYP2A6 CYP1A2 CYP1A1 CYP2E1 ADH1A ADH1C CYP3A4 CYP4A11 ADH7 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260211%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB NR1B3 RXRG RARA RXRA RARB DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260211%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDF11 FST TGFB1 ANOS1 CELSR1 BMP4 SHH SPRY1 GRIP1 PAX2 SIX1 SMAD1 BMPER SMO GPC3 CRIM1 BMP7 BMP5 CTDNEP1 RARA HOXD11 FRAS1 HOXA11 FREM1 FREM2 GLI3 SALL1 ETV4 SIX2 BMPR1A BMPR2 NR1B3 EYA1 GDNF BMP2 CCND1 DCN RET ETV5 RARB HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP561%HOMO SAPIENS Heme biosynthesis FECH UROD UROS HMBS CPOX ALAS1 ALAS2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260211%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex FLT3 GABPB1 BCL2L1 BCL2 SMARCA4 CREBBP ETV6 SMAD4 EP300 FOXO3A ZFX ATM GABPA PTEN TERF2 DNMT3B MCL1 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP4792%HOMO SAPIENS Purine metabolism ADSL PNP HEL-S-70p XDH AMPD1 APRT IMPDH1 ADA ADSS DGUOK HPRT1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260211%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling ITGB1 MAP4K1 MAPK8 PAK1 PTGS2 STAT3 CRK JUN DOCK1 SRC PIK3CA RAP1A HGF MAPK1 CRKL MAPK3 MET PTPN11 MAP2K1 MAP2K2 RAPGEF1 RAF1 PXN FOS PTEN ITGA1 PTK2B HRAS GRB2 SOS1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260211%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRAK1 TLR4 IRAK4 IRF7 MAPK8 MYD88 RELA CHUK TRAF3 RELB TRAF6 IKBKG IL10 MAP3K7IP1 NFKB1 IL6 CXCL8 TNF CCL4 ELANE MAPK14 NFKBIA TLR7 MAP3K7 IRF1 NFKB2 IKBKB LCN2 REL TLR8 CCL3 VCAM1 IL1A AUTOPHAGY%WIKIPATHWAYS_20260211%WP4923%HOMO SAPIENS Autophagy DKFZp762B153 RB1CC1 WIPI2 ATG5 ATG14 AMBRA1 PRKAA2 RPTOR MTOR ULK1 PIK3R4 DEPTOR PRKAG1 MLST8 PRKAG2 ATG3 PRKAG3 PRKAA1 ATG9A ATG12 PRKAB2 ATG16L1 PRKAB1 AKT1S1 ATG101 UVRAG PURINERGIC SIGNALING%WIKIPATHWAYS_20260211%WP4900%HOMO SAPIENS Purinergic signaling P2RY11 ADORA2B GNAI1 P2RY6 P2RY4 P2RX6 GNAI3 P2RY2 P2RY1 PANX1 GNAS GNAO1 ADORA2A P2RY10 P2RY14 GNAZ P2RY8 GNAT2 GNAT3 GNAT1 LPAR4 P2RX7 P2RX5 GNA11 P2RX4 P2RX3 P2RX2 P2RX1 P2RY13 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260211%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions TLR4 NLRP3 MMP9 EGFR SMAD2 CNP EBI3 SIRPA FAM20C STAT1 PDGFA MBP CD47 IGF1 VEGFA TGFBR1 NKX2-2 IL10RA FOXO1 IGF1R MOG TYK2 PDGFRA OLIG1 CX3CR1 OLIG2 SOCS3 TNF CCL1 MAPK14 CTLA4 NKX6-1 CCL20 IL33 CSPG4 ITGB3 CD80 HEXB IL10RB IL12A CD68 NFKB2 IFNG STAT5B ITGA2 JAK3 OSM IL2RA IL2RB CD44 IL2RG MYD88 TGFB1 STAT3 CXCL12 TGFBR3 STAT4 IL12RB1 IL10 CCR8 FOXP3 NFKB1 HTR7 IL2 IL4 IL6 SPP1 NOS2 SOX9 PDCD1 CDC42 SSTR2 FOXO3A FOXO4 ROS1 ITGAV IKZF2 IL18 AIF1 CCN3 NKX6-2 TNFRSF1B IL1B KLRG1 RAC1 APOD MCAM JAK1 GSDMD TMEM119 TGFBR2 CXCL1 AREG CCR6 RETT SYNDROME%WIKIPATHWAYS_20260211%WP4312%HOMO SAPIENS Rett syndrome CDKL5 KCNJ10 XAB2 MEF2C TBL1XR1 IMPDH2 CHD4 HAP1 SCN8A HTT ACTL6B BRAF CRK SCN1A GABBR2 SCN2A HDAC5 HDAC8 SYNE2 GNAO1 NCOR1 STXBP1 NCOR2 SRRM3 SMARCA4 TAF1B FOXG1 HDAC1 SHANK3 SMARCA1 SMC1A TBL1X GRIN2B TCF4 SYNGAP1 EIF2B2 GABRA3 KDM5B TRRAP GPS2 RHOBTB2 CECR2 HIVEP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MEF2C MIXL1 MESP1 THY1 NKX2-5 NCAM1 INHBA SIRPA IGF1 ZFP42 BMP4 POU5F1 ISL1 INS KDR PDGFRA PAX6 NRG1 GATA4 SOX1 SOX2 MAPK14 TBXT NOTCH1 BMP1 CXCR4 MESP2 FOXA2 IGF2 TBX20 IRX4 TBX5 KIT MYL2 WNT3A TNNI3 GSK3B SOX17 SCN5A TGFB1 LIN28A LIN28B ROR2 DKK1 NODAL FGF2 NOG MYH6 MYLK3 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP272%HOMO SAPIENS Blood clotting cascade SERPINB2 F13B PLAT KLKB1 PLG FGA VWF F2 HEL-S-78p KLNA1 F7 SERPINF2 F3 F5 F10 F8 F11 F9 WNT SIGNALING%WIKIPATHWAYS_20260211%WP428%HOMO SAPIENS Wnt signaling CAMK2A CCND2 DAAM2 PRICKLE2 GPC4 CAMK2G CTBP2 NFATC3 NFATC2 NFATC4 INVS WIF1 CCND3 MAP3K7 CCND1 MAPK9 MAPK8 FZD10 ROR2 FRAT1 FRAT2 CSNK2A1 CSNK2A3 NFATC1 CSNK2A2 CSNK1E DKK1 DKK2 DKK4 SFRP4 CSNK2B PPP3R1 PPP3R2 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 PPP3CA RAC1 PPP3CC PLCB4 PLCB1 PLCB2 DAAM1 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CHD8 RYK ROR1 WNT5B SOST LEF1 NKD1 NKD2 PRKCB DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 WNT3A VANGL1 KREMEN1 SENP2 SFRP5 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 ROCK2 JUN WNT16 NLK LRP5 LRP6 ARHA APC CTBP1 PLCB3 CAMK2D ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 PPAR SIGNALING%WIKIPATHWAYS_20260211%WP3942%HOMO SAPIENS PPAR signaling CPT2 ME1 RXRB CD36 RXRG FABP4 DBI PLIN1 NR1C1 PDPK1 ANGPTL4 UCP1 RXRA APOA5 OLR1 APOC3 FADS2 SCD CYP7A1 APOA2 CYP27A1 PCK1 HEL-S-28 CYP8B1 PLTP FABP1 PPARG SLC27A5 LPL SLC27A1 EHHADH CPT1C NR1C2 UBC NR1H3 SLC27A4 CYP4A11 PCK2 ACSL1 ACOX1 AQP7 ERBB SIGNALING%WIKIPATHWAYS_20260211%WP673%HOMO SAPIENS ErbB signaling CAMK2A EGFR PAK1 NRG4 NRAS BRAF CAMK2G FOXO1 SRC SHC1 PDPK1 MYC AKT3 NRG1 HBEGF ERBB2 MAP2K4 NRG2 EIF4EBP1 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC4 SHC2 MAP2K1 SHC3 MAP2K2 TGFA BCL2L11 ERBB3 EGF RAF1 RPS6KB2 CDKN1B RPS6KB1 PRKCB PRKCA PIK3R3 PAK6 PAK4 STAT5B CCND1 GSK3B PIK3CD MAPK10 MAPK9 MAPK8 ARAF PLCG2 CRK JUN PIK3CA NRG3 CRKL BAD MTOR PIK3R2 PIK3R1 MDM2 CBL EREG BTC NCK2 NCK1 CDKN1A ABL2 HRAS CAMK2D GRB2 AREG SOS1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260211%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNT1 ACTA2 MYL3 TNNT3 MYH8 HEL113 MYL1 MYOM1 MYBPC3 TNNC1 TNNI1 ACTN2 DMD HEL-S-273 HEL-S-108 ACTN4 TTN ACTG1 tmp_locus_29 TPM3 TPM1 TMOD1 TCAP MYH6 ACTA1 MYL4 TNNI2 MYL2 TNNI3 TNNC2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260211%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 OXCT1 ACAT1 UCP2 BDH1 SLC25A20 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 SRD5A2 POR AKR1D1 AKR1C4 HSD3B1 SULT2A1 HSD17B3 CYP17A1 HSD17B2 AKR1C1 CYP3A7 AKR1C2 CYP3A4 HSD17B4 HSD17B1 HSD3B2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260211%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology HEL-S-15 ADCY3 ADCY1 SMAD2 ADCY8 SMAD4 ADCY6 WWTR1 TGFB1 LBR NRAS SYNE4 CTGF SYNE3 SUN1 YY1AP1 PLEC HEL-S-7a SYNE2 MAPK1 SYNE1 ARHA KRAS SOS2 MAPK3 TMEM43 HEL-S-61 MAP2K1 MAP2K2 BANF1 EMD ADCY9 LEMD3 HRAS GRB2 SOS1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m ERN1 ASNS NFE2L2 DNAJB11 BBC3 XBP1 SULT1E1 HEL-S-89n EIF2A EDEM1 HEL-S-99n DNAJC3 ERP27 TRIB3 DDIT3 DNAJB9 UBE2E1 PPP1R15A BCL2L11 NARS1 ATF3 ATF4 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL SMAD2 PARP1 SMAD4 TGFB1 PPARG FBN1 ZMPSTE24 FNTA BANF1 LMNA INS KCNJ6 MUCL3 SPRTN ICMT LMNB2 WRN FFAR3 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260211%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1A2 CAMK2A NPPB CASP9 PDE3A RELA PBR GUCY1B1 CAMK2G GRIN1 NFKB1 CNGB1 ACTN2 DLG4 CNGA3 CNGA4 AKAP9 TNF CNGB3 NEFL NOS2 PDE2A BAD NFKBIA CALM1 BCL2 NPPA GRIN2B IFNG CREB1 IL1B CNGA1 CAMK2D CYCS AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260211%WP5526%HOMO SAPIENS Age related macular degeneration PRKAG2 PRKAG3 PRKAA1 SIRT1 PRKAB2 RPS6KB1 PRKAB1 PRKAA2 PMAIP1 PPARGC1A MAPK3 RPTOR HEL-S-32 MTOR PARP2 PRKAG1 MLST8 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260211%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CALCA ACTA2 SMAD2 CASP9 SMAD4 CASP3 BAK1 TGFB1 APAF1 TRPV5 BAX BRAF TGFBR1 PDE1B TNFRSF1A PIK3CA MAPK1 CASP8 SEC16B MAP3K5 HEL-S-41 MTOR FFAR3 PPP3R1 RAF1 TNFSF11 PTH MCU FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260211%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CASP9 MAPK8 PAK1 CASP3 APAF1 CASP10 FAF1 MAP3K1 JUN DFFB MAPKAPK3 DFFA FAS ARHGDIB LMNB2 MAP2K4 TNF CASP8 RIPK2 NFX1 SMIM40 PRKDC BCL2 FADD PARP1 ACTG1 SPTAN1 TNFSF6 CASP6 PS1TP5BP1 LMNA MAP3K7 ACTA1 RB1 HEL-S-102 MAPKAPK2 CYCS IL1A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260211%WP4963%HOMO SAPIENS p53 transcriptional gene network ADORA2B BTG2 AURKA PML ZMAT3 PERP LIF ISG15 FAS CX3CL1 TP53I3 CDK2 PRKAA2 TNF GPX1 CCL2 RPTOR SMR3B DEPTOR ACAD11 SERPINB5 PRKAG1 MLST8 SCO2 PRKAG2 ADGRB1 NOTCH1 DRAM1 RPRM SIVA1 MGMT ULBP2 PRKAG3 ULBP1 SESN2 PRKAA1 BBC3 TP53AIP1 IRF9 PIDD1 TNFSF6 DDIT4 SESN1 TIGAR FUCA1 PRKAB2 CPT1C PRKAB1 AKT1S1 SLC7A11 DDB2 RRM2B PMAIP1 TNFRSF10B TRAF4 CCNG1 POLK TSC2 XPC ERCC5 APAF1 BAX SFN MSH2 THBS1 FANCC ULK2 ULK1 MTOR GADD45A PCNA TNFRSF10D NCF2 CCNE1 E2F7 CDKN1A PTEN GLS2 TP53INP1 XRCC5 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap MAT1A CDO1 ADK MTR CTH HEL-S-182mP HEL-S-61p CBS BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 SST FOXO1 SFRP1 DKFZp781O1323 CTNNB1 DKK1 WNT4 SMAD1 BMP2 DCN LEFTY2 BCL2L11 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260211%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3CA HLA-DRB1 PIK3CD PIK3R3 CD80 PPP2CA PTPN11 CTLA4 PTPN6 PIK3R2 PIK3R1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260211%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT1 HEL-S-277 PRMT7 NOS2 CARM1 PRMT3 PRMT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260211%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 HGS RAF1 ARAF PDCD6IP BRAF NRAS RAB5B RAB5C RRAS2 RRAS MAPK1 KRAS RAB27A MAPK3 HRAS RAB5A IL11 SIGNALING%WIKIPATHWAYS_20260211%WP2332%HOMO SAPIENS IL11 signaling BIRC5 TGFB1 RELA CHUK STAT1 STAT3 RUNX2 PIAS1 SRC TYK2 PDPK1 SOCS3 IL11 MAPK1 IL11RA BGLAP FYN MAPK3 ATF1 PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2 YES1 RAF1 FES RPS6 RPS6KA1 RPS6KB1 IBSP PTPA IKBKB CREB1 JAK1 HRAS ITGA2 GRB2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CIAO2B COX11 ERBB2 MAPK1 ADRA2B ARHA MAPK3 CIAO2A ANKRD23 SNRNP200 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 DUSP2 CNNM4 FER1L5 STARD7 SEMA4C ARID5A COL2A1 ASTL NEURL3 ZP2 KANSL3 PLXNB2 MMS19 IL5 SIGNALING%WIKIPATHWAYS_20260211%WP127%HOMO SAPIENS IL5 signaling GSK3B SPRED1 STAT1 STAT3 JUN SHC1 IL2 IL5RA MAPK1 CSF2RB KRAS MAPK3 PTPN11 MAP2K1 LYN MAP2K2 PIK3R2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 RPS6KA1 RPS6KB1 GSK3A JAK1 STAT5B BTK GRB2 SOS1 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260211%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NLRP3 CARD9 CARD6 ACAP1 NLRP10 NOD2 CASP9 NLRP7 NLRP2 NLRP12 RELA CHUK IKBKG NLRP1 NAIP CASP8 DUOX2 CASP5 RIPK2 NFKBIA NDUFA13 PRDM1 AIM2 PYCARD COPS6 IL18 IKBKB IL1B RAC1 NOD1 NLRC4 MEFV AAMP CARD8 ERBIN LEPTIN SIGNALING%WIKIPATHWAYS_20260211%WP2034%HOMO SAPIENS Leptin signaling PDE3B RELA SH2B1 STAT1 CISH FOXO1 SRC SHC1 SOCS2 SOCS3 IRS1 ERBB2 PRKAA2 EIF4EBP1 MAPK1 FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 MAP2K2 EIF4E SOCS7 ACACA RAF1 PRKAA1 RPS6 LEPR RPS6KB1 ACACB REL STAT5B CFL2 KHDRBS1 GSK3B LEP KPNA4 MAPK8 CHUK STAT3 PLCG2 IKBKG ROCK1 PLCG1 ROCK2 NFKB1 SP1 ARHA BAD MTOR PIK3R2 PIK3R1 CDC42 RPS6KA1 GSK3A PTEN IKBKB CREB1 RAC1 JAK1 HRAS GRB2 NCOA1 SOS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260211%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC1H1 DYNC2H1 DYNLRB2 IFT46 DYNLT1 IFT140 DYNC1LI2 IFT81 DNCL1 DYNLT3 IFT80 WDR35 IFT27 DYNLL2 IFT25 IFT43 DYNC1I1 DYNLT2B IFT22 DYNC1LI1 DYNC2I2 DYNC2LI1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260211%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine HEL-S-7a ADRB1 ADCY3 ADCY1 ADRB2 ADCY8 ADCY6 ADCY9 ADRA2C ADRA2B ADRA2A ADRA1D PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260211%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity ABCC2 CYP24A1 ABCD2 CYP26A1 NR1C1 CYP27B1 CYP3A4 NR1I3 NR1i1 ABCG5 CYP7A1 ABCD3 NR1i2 NR1H4 CYP8B1 RARA CYP2C9 PPARG ABCB4 CYP2B6 CYP1A2 ABCB1 ABCA1 CYP2E1 ABCC3 CYP4B1 NR1C2 ABCG1 ABCB11 NR1B3 NR1H3 CYP4A11 RARB HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA2 PDHA1 ACACA NFE2L2 PRKAA1 RPS6 VEGFA PRKAB1 ACACB EGLN1 HIF1A HEL-S-133P SLC11A2 PRKAG1 KEAP1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 AKR1D1 AKR1C1 AKR1C4 AKR1C2 CYP3A4 CYP11B2 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 LTC4S DECR2 ALOX5 ABCC1 ALOX5AP PTGR1 DECR1 CYP4F3 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX VLDLR NDEL1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260211%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP HIST1H2BE CDKN2A FZR1 RPS6KA2 RELA CEBPB UBE2D1 EHMT1 CDK4 RPS6KA3 CDK2 MAPK1 MAPK3 H2BC21 H2AX CDKN1B UBB ANAPC1 CCNA2 RPS27A CDKN2D CDKN2B CDKN2C H3C8 CDC26 STAT3 VENTX ANAPC15 C10orf104 UBE2S CDC27 JUN UBE2C MAPK7 NFKB1 H3C15 IL6 CXCL8 CDK6 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 RPS6KA1 H2BC8 CDC23 H4C9 H2AC6 HIST1H4L ANAPC7 FOS H2BC3 ANAPC5 UBC H2BC1 CDKN1A ANAPC2 H2BC17 H3F3B H2BC12 ANAPC11 H2BC13 H2AJ H2BC14 UBE2E1 H2BC15 IGFBP7 H2AC20 H2BC11 IL1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260211%WP3645%HOMO SAPIENS NAD biosynthetic pathways NADSYN1 TDO2 NMNAT1 IDO1 PARP4 PARP1 NAPRT NAMPT BST1 SIRT1 SIRT3 TNKS2 SIRT6 SIRT4 HEL-S-90n SIRT5 SIRT7 TNKS PARP2 SIRT2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260211%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HEXA HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB GLB1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP129%HOMO SAPIENS Matrix metalloproteinases MMP16 MMP9 MMP15 MMP23B MMP17 MMP19 TCF20 MMP26 TNF TIMP4 TIMP3 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 hEMMPRIN MMP7 MMP2 MMP3 MMP10 MMP12 MMP11 TIMP1 MMP14 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260211%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism NR1D2 SMAD4 BMP6 RUNX2 IGF1 BMP4 DKFZp781O1323 BHLHE41 HMGB1 CSF1 PRKAA2 CTF1 LAMP2 NOTCH1 BCL2 CRY1 ATG3 BMP5 SP7 SOST ATG12 PTH TNFRSF11B CTSK ATG16L1 ATG101 PLEKHM1 CTHRC1 MAP1LC3A SQSTM1 ATG10 BMP2 PER1 CALCA LEP DKFZp762B153 RB1CC1 TGFB1 TRAF6 WNT16 VCP RORB NFATC1 BMP3 ATG5 DKK1 IL6 LRP5 AMBRA1 ARHGAP4 FYCO1 DRAM2 SMAD1 SEMA4D ULK1 MTOR IL3 SEMA3A SMAD9 TNFSF11 WNT10B EFNB2 BHLHB2 TNFRSF11A NPAS2 BMPR2 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260211%WP259%HOMO SAPIENS Nifedipine activity PCNA KDR BDKRB2 CYP3A4 MAPK1 PTK2B HEL-S-44 MAP2K1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2876%HOMO SAPIENS Pregnane X receptor pathway NR1i2 ABCC2 CYP2C9 UGT1A3 CYP2A6 CYP2B6 SULT2A1 DNAJC7 UGT1A1 ABCB1 UGT1A9 FOXO1 ABCC3 SRC SLCO1B1 UGT1A4 CYP2C19 CYP3A7 CYP3A4 RXRA PPARGC1A SRPX2 CYP4F12 NCOA1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260211%WP35%HOMO SAPIENS G protein signaling PRKD3 ADCY3 ADCY1 PDE4A ADCY8 ADCY6 GNA14 GNG3 GNG5 GNG4 NRAS GNG7 GNG8 PDE1C AKAP5 PDE1B AKAP10 PDE1A PDE8A AKAP9 KRAS PDE7B PDE7A GNAZ PRKACG PRKCH PRKCB GNG10 GNA11 PRKCE GNGT2 PRKCA ADCY9 PRKAR1B GNAL PRKAR1A PRKCI PRKCQ PRKD1 PRKCZ GNAI1 GNAI3 GNG12 GNG11 GNG13 KCNJ3 GNA15 RRAS GNB2 ARHA GNB1 GNAS HEL159 GNB3 AKAP12 GNAO1 AKAP11 GNB5 AKAP7 AKAP6 CALM1 AKAP4 GNGT1 PDE4B PDE4D ARHGEF1 AKAP8 GNA13 PLCB3 PPP3CA PPP3CC HRAS ATM SIGNALING%WIKIPATHWAYS_20260211%WP2516%HOMO SAPIENS ATM signaling CHEK1 RAD9A MAPK9 TP73 MRE11A MDC1 IKBKG JUN CASP2 RAD50 TP53BP1 RAD51 CDK2 CRADD ATF2 GADD45A MDM4 H2AX PIDD1 MDM2 CCNE1 ATM TLK1 NBN RIPK1 SMC1A CDKN1A BRCA1 CCNB1 CREB1 CDC2 CHEK2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 FADD CASP9 CASP3 APAF1 TNFSF6 CASP6 MAP3K1 TNFRSF1A CASP2 RIPK1 NFKB1 FAS CASP8 AIFM1 CYCS PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXT1 SLC35B2 CANT1 BPNT2 PAPSS2 CHST3 XYLT2 XYLT1 CHSY1 CSGALNACT1 B3GAT3 SLC26A2 B3GALT6 EXT2 CHST14 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260211%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP1 AXIN1 TNK2 TNK1 BTRC SKP1 DVL1 CTNNB1 DVL2 RBX1 DVL3 PARP10 APC PLK1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260211%WP2328%HOMO SAPIENS Allograft rejection HLA-DQA2 HLA-DQA1 HEL113 STAT1 VEGFA HLA-DRB1 FAS PDGFRA HLA-B HLA-F CCL19 HLA-G TNF HLA-DOA HLA-E HLA-DRA HLA-DOB CTLA4 AGTR1 HLA-DPA1 HLA-DQB1 CCL21 HLA-DMB C1QB HLA-DPB1 C1QA CD40 LRRK2 TNFSF6 CD80 C4B_2 C2 C4A C8A IL12B IL12A CXCR5 HEL-S-62p CD40LG IFNG GDNF HARS1 IL17A IL2RA C1QC IF2B1 HLA-DRB5 CASP9 PRKCZ IL-21 CASP3 TGFB1 HLA-DMA CXCL12 PRF1 IL10 IL13 CSNK2A2 FOXP3 HLA-A IL2 IL4 IL5 TUBA1B CXCL8 C6 C7 CASP8 HLA-C C9 CD55 GNLY BHMT2 PECR ABCB1 GABPA IL1B MICA CXCL9 CXCL13 CXCL11 IL1A PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260211%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome SNRPN NUP133 CDKN2A CCND2 PCM1 NUP98 RAE1 BDNF INS CDK4 DLX5 HEL-S-71 MSX1 HERC2 EIF4E TACR3 POM121 RNF8 PCSK1 RB1 CDKN2B CDKN2C CCND1 GHRH BBS4 GHRL PRKCZ AHCTF1 KISS1 UBE3A TUBGCP5 NIPA1 NDN TUBGCP6 TUBGCP4 NIPA2 FSHB GABRG2 SNURF ATP10A NUP85 TPR LHB CGA NUP107 CDK6 MDM4 POMC OXT NUP62 GNRH1 NUP188 NPAP1 NUP214 NDC1 MAGEL2 MDM2 GOLGA8S NUP88 GABRB3 NUP210 CYFIP1 GOLGA6L2 GABRR3 NUP93 FEZ1 FMR1 GABRR1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 GABRA5 NGF SEH1L AAAS GABRG3 NUP160 GABRG1 NHLH2 NUP42 RANBP2 NUP155 CDC6 NUP153 TYR NUP35 MKRN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP453%HOMO SAPIENS Inflammatory response pathway COL1A1 LAMA5 LAMB2 COL3A1 IL2RG ZAP70 TNFRSF1A THBS1 IL2 IL4 VTN IL5 IL5RA COL1A2 LAMB1 CD40 CD80 LAMC2 LAMC1 CD40LG IFNG TNFRSF1B LCK THBS3 IL2RA IL2RB GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260211%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG8 ALG9 ALG2 TUSC3 ALG14 ALG13 ALG3 B4GALT1 ALG12 ALG11 DPM3 DPM2 GCS1 DPM1 MAGT1 ALG1 ALG6 MGAT2 SRD5A3 DOLK DPAGT1 MPDU1 GMPPB CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CALM1 ATP2A1 HDAC2 CD8B1 MEF2D EP300 HDAC1 CD8A CABIN1 PLCG1 ZAP70 PPP3CA PPP3CC NFATC2 LCK ITPRIP RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260211%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway RS1 ANGPT4 BIRC5 ANGPT2 TNIP2 ITGB1 TNIP3 EGFR ANGPT1 PAK1 RELA NRAS GRB7 FOXO1 SRC RAD51 CTNNB1 MYC ERBB2 EIF4EBP1 MAPK1 MAPK12 KRAS MAPK3 MAPK13 PTPN11 MAPK11 MAPK14 NFKBIA GRB14 PXN STAT5B CASP9 MAPK9 MAPK8 CHUK STAT3 BAX YAP1 CRK IKBKG MSH2 PIK3CA NFKB1 NOS2 BAD PIK3R1 NCK1 IKBKB MMP2 RAC1 HRAS GRB2 SOS1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 NOP2 CDKN1B FLT1 FOXO3A GAB2 ABCB1 LYL1 SKP2 PDGFRA CSF1R MYC ABCG2 KIT BCR GADD45A CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260211%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EGFR CREBBP KDM5C EFCAB3 FLT1 PBRM1 EP300 SDSL PGBD5 LDHD VEGFA PSAT1 CAMK1 PSPH ENO1 KDR KSR1 HEL-S-68p SETD2 BHLHE41 PDGFRA HEL-S-30 SSPN RPTOR PHGDH DEPTOR MLST8 ACACA FASN HEL-S-51e GRB10 RHEB BAP1 AKT1S1 LDHB SQSTM1 ACACB HIF1A HEL-S-133P HK3 HEL-S-32 CEP290 KCNJ2 ME1 PGM2 MAP2K5 TSC2 TSC1 STAT3 HEL-S-162eP PFKL ACLY ENO2 PFKM ENO3 PLOD2 PFKP HEL-S-49 HEL-S-87p ENPP3 HK2 VHL MTOR RAPGEF5 PKLR ALDOB SHMT1 PTEN